title: Anti-diabetic properties of Momordica charantia L. polysaccharide in alloxan-induced diabetic mice.
abstract: A water-soluble polysaccharide (MCP) was isolated from the fruits of Momordica charantia L., and the hypoglycemic effects of MCP were investigated in both normal healthy and alloxan-induced diabetic mice. MCP was orally administered once a day after 3 days of alloxan-induction at 100, 200 and 300mg/kg body weight for 28 day. Results showed that fasting blood glucose level (BGL) was significantly decreased, whereas the glucose tolerance was marked improvement in alloxan-induced diabetic mice, and loss in body weight was also prevented in diabetic mice compared to the diabetic control group. The dosage of 300mg/kg body weight exhibited the best effects. In addition, MCP did not exhibit any toxic symptoms in the limited toxicity evaluation in mice. The results suggest that MCP possess significantly dose-dependent anti-diabetic activity on alloxan-induced diabetic mice. Hence, MCP can be incorporated as a supplement in health-care food, drugs and/or combined with other hypoglycemic drugs.
authors: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China.
authors: Xin
authors: X
authors: Xu
authors: College of Yingdong Food Science and Engineering, Shaoguan University, Shaoguan 512005, China.
authors: Bin
authors: B
authors: Shan
authors: College of Yingdong Food Science and Engineering, Shaoguan University, Shaoguan 512005, China.
authors: Cai-Hu
authors: CH
authors: Liao
authors: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. Electronic address: jhxie@ncu.edu.cn.
authors: Jian-Hua
authors: JH
authors: Xie
authors: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors: Ping-Wei
authors: PW
authors: Wen
authors: School of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China.
authors: Jia-Yi
authors: JY
authors: Shi
mesh_terms: D000496:Alloxan / Q000009:adverse effects; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D023382:Toxicity Tests, Acute
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides; D000496:Alloxan
keywords: Alloxan-induced; Anti-diabetic; Hypoglycemic effect; Momordica charantia L.; Polysaccharide