title: Fragments and hot spots in drug discovery.
authors: Department of Biomedical Engineering, Boston University, Boston, MA, USA.|Department of Chemistry, Boston University, Boston, MA, USA.
authors: Sandor
authors: S
authors: Vajda
authors: Department of Chemistry, Boston University, Boston, MA, USA.
authors: Adrian
authors: A
authors: Whitty
authors: Department of Biomedical Engineering, Boston University, Boston, MA, USA.
authors: Dima
authors: D
authors: Kozakov
mesh_terms: D001665:Binding Sites; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D011506:Proteins / Q000737:chemistry; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology
chemical_list: D011506:Proteins; D054852:Small Molecule Libraries
keywords: druggability; fragment conservation; ligand design