title: Complementary Flavonoid Prenylations by Fungal Indole Prenyltransferases.
abstract: Flavonoids are found mainly in plants and exhibit diverse biological and pharmacological activities, which can often be enhanced by prenylations. In plants, such reactions are catalyzed by membrane-bound prenyltransferases. In this study, the prenylation of nine flavonoids from different classes by a soluble fungal prenyltransferase (AnaPT) involved in the biosynthesis of the prenylated indole alkaloid acetylaszonalenin is demonstrated. The behavior of AnaPT toward flavonoids regarding substrate acceptance and prenylation positions clearly differs from that of the indole prenyltransferase 7-DMATS. The two enzymes are therefore complementary in flavonoid prenylations.
authors: Institut für Pharmazeutische Biologie und Biotechnologie, Philipps-Universität Marburg , Marburg 35037, Germany.
authors: Kang
authors: K
authors: Zhou
authors: Institut für Pharmazeutische Biologie und Biotechnologie, Philipps-Universität Marburg , Marburg 35037, Germany.
authors: Xia
authors: X
authors: Yu
authors: Fachbereich Chemie, Philipps-Universität Marburg , Marburg 35032, Germany.
authors: Xiulan
authors: X
authors: Xie
authors: Institut für Pharmazeutische Biologie und Biotechnologie, Philipps-Universität Marburg , Marburg 35037, Germany.
authors: Shu-Ming
authors: SM
authors: Li
mesh_terms: D004122:Dimethylallyltranstransferase / Q000378:metabolism*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000378:metabolism; D007211:Indoles / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054876:Prenylation; D013379:Substrate Specificity
chemical_list: D005419:Flavonoids; D007211:Indoles; D004122:Dimethylallyltranstransferase