title: Praziquantel treatment for yellowtail kingfish (Seriola lalandi): dose and duration safety study.
abstract: Regulatory approval is being sought to use praziquantel (PZQ) to treat flukes infecting yellowtail kingfish (YTK), but accurate safety data were not available. We investigated the effect of increased doses or prolonged exposure of orally administered PZQ on YTK by assessing changes in haematological and biochemical characteristics, and mortality. Fish were intubated daily for 3 days with 0, 100, 300 and 500 mg PZQ kg(-1) BW day(-1) or once daily for 9 days at 0 and 100 mg PZQ kg(-1) BW day(-1). Blood was taken 24 h after the cessation of treatment. There was no significant difference between any of the haematological or biochemical indices in YTK treated with PZQ and controls, indicating that PZQ is safe for use at 100 mg PZQ kg(-1) BW day(-1) in YTK and that exposure to high doses or prolonged duration does not have negative effects on the YTK haematological or biochemical parameters we measured.
authors: Lincoln Marine Science Centre, School of Biological Sciences, Flinders University, Port Lincoln, SA, Australia. james.forwood@flinders.edu.au.
authors: James M
authors: JM
authors: Forwood
authors: Lincoln Marine Science Centre, School of Biological Sciences, Flinders University, Port Lincoln, SA, Australia.
authors: Erin J
authors: EJ
authors: Bubner
authors: Future Fisheries Veterinary Services Pty Ltd, East Ballina, NSW, 2478, Australia.
authors: Matt
authors: M
authors: Landos
authors: Lincoln Marine Science Centre, School of Biological Sciences, Flinders University, Port Lincoln, SA, Australia.
authors: Trent
authors: T
authors: D'Antignana
authors: South Australian Research and Development Institute (SARDI), West Beach, SA, 5024, Australia.|Marine Innovation Southern Australia (MISA), West Beach, SA, 5024, Australia.
authors: Marty R
authors: MR
authors: Deveney
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005393:Fish Diseases / Q000517:prevention & control; D006374:Helminthiasis, Animal / Q000517:prevention & control; D006403:Hematologic Tests; D010473:Perciformes / Q000097:blood*; D011223:Praziquantel / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000871:Anthelmintics; D011223:Praziquantel
keywords: Biochemistry; Haematology; Intubation; Toxicity