title: An interactive genome browser of association results from the UK10K cohorts project.
abstract: High-throughput sequencing technologies survey genetic variation at genome scale and are increasingly used to study the contribution of rare and low-frequency genetic variants to human traits. As part of the Cohorts arm of the UK10K project, genetic variants called from low-read depth (average 7×) whole genome sequencing of 3621 cohort individuals were analysed for statistical associations with 64 different phenotypic traits of biomedical importance. Here, we describe a novel genome browser based on the Biodalliance platform developed to provide interactive access to the association results of the project.
  
  
  METHODS
  The browser is available at http://www.uk10k.org/dalliance.html. Source code for the Biodalliance platform is available under a BSD license from http://github.com/dasmoth/dalliance, and for the LD-display plugin and backend from http://github.com/dasmoth/ldserv.
authors: Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK.
authors: Matthias
authors: M
authors: Geihs
authors: Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK.
authors: Ying
authors: Y
authors: Yan
authors: Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK.
authors: Klaudia
authors: K
authors: Walter
authors: Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK.
authors: Jie
authors: J
authors: Huang
authors: Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK.
authors: Yasin
authors: Y
authors: Memari
authors: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield Grove, Bristol, UK.
authors: Josine L
authors: JL
authors: Min
authors: Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK.
authors: Daniel
authors: D
authors: Mead
authors: Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK, Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King's College London School of Medicine, Guy's Hospital, London SE1 9RT, UK.
authors: Tim J
authors: TJ
authors: Hubbard
authors: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield Grove, Bristol, UK.
authors: Nicholas J
authors: NJ
authors: Timpson
authors: EMBL-EBI, Hinxton CB10 1SD, UK and.
authors: Thomas A
authors: TA
authors: Down
authors: Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK, Department of Haematology, University of Cambridge, Cambridge CB2 1TN, UK.
authors: Nicole
authors: N
authors: Soranzo
mesh_terms: D056726:Genetic Association Studies; D014644:Genetic Variation; D015894:Genome, Human; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D015810:Linkage Disequilibrium; D012984:Software