title: Cerebrospinal fluid volumetric MRI mapping as a simple measurement for evaluating brain atrophy.
abstract: OBJECTIVE
  To assess whether volumetric cerebrospinal fluid (CSF) MRI can be used as a surrogate for brain atrophy assessment and to evaluate how the T2 of the CSF relates to brain atrophy.
  
  
  METHODS
  Twenty-eight subjects [mean age 64 (sd 2) years] were included; T1-weighted and CSF MRI were performed. The first echo data of the CSF MRI sequence was used to obtain intracranial volume, CSF partial volume was measured voxel-wise to obtain CSF volume (VCSF) and the T2 of CSF (T2,CSF) was calculated. The correlation between VCSF/T2,CSF and brain atrophy scores [global cortical atrophy (GCA) and medial temporal lobe atrophy (MTA)] was evaluated.
  
  
  RESULTS
  Relative total, peripheral subarachnoidal, and ventricular VCSF increased significantly with increased scores on the GCA and MTA (R = 0.83, 0.78 and 0.78 and R = 0.72, 0.62 and 0.86). Total, peripheral subarachnoidal, and ventricular T2 of the CSF increased significantly with higher scores on the GCA and MTA (R = 0.72, 0.70 and 0.49 and R = 0.60, 0.57 and 0.41).
  
  
  CONCLUSIONS
  A fast, fully automated CSF MRI volumetric sequence is an alternative for qualitative atrophy scales. The T2 of the CSF is related to brain atrophy and could thus be a marker of neurodegenerative disease.
  
  
  CONCLUSIONS
  • A 1:11 min CSF MRI volumetric sequence can evaluate brain atrophy. • CSF MRI provides accurate atrophy assessment without partial volume effects. • CSF MRI data can be processed quickly without user interaction. • The measured T 2 of the CSF is related to brain atrophy.
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O.Box 85500, 3508, GA, Utrecht, The Netherlands. j.devis-2@umcutrecht.nl.
authors: J B
authors: JB
authors: De Vis
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O.Box 85500, 3508, GA, Utrecht, The Netherlands.
authors: J J
authors: JJ
authors: Zwanenburg
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O.Box 85500, 3508, GA, Utrecht, The Netherlands.
authors: L A
authors: LA
authors: van der Kleij
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O.Box 85500, 3508, GA, Utrecht, The Netherlands.
authors: J M
authors: JM
authors: Spijkerman
authors: Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: G J
authors: GJ
authors: Biessels
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O.Box 85500, 3508, GA, Utrecht, The Netherlands.
authors: J
authors: J
authors: Hendrikse
authors: Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O.Box 85500, 3508, GA, Utrecht, The Netherlands.|Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark.
authors: E T
authors: ET
authors: Petersen
mesh_terms: D000328:Adult; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000175:diagnosis*; D002555:Cerebrospinal Fluid; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D013702:Temporal Lobe; D055815:Young Adult
keywords: Brain atrophy; Brain volume; Cerebrospinal fluid; Imaging; Magnetic resonance imaging