title: ProGRP is a possible tumor marker for patients with Ewing sarcoma.
abstract: We analyzed serum ProGRP levels in patients with Ewing sarcoma, and found that 5 out of 9 patients had elevated levels; the values range equally with those of patients with limited disease of small-cell lung carcinoma. Serum ProGRP levels in patients with bone and soft tissue malignancies other than Ewing sarcoma are not elevated. Immunohistochemical studies demonstrated that ProGRP-like immunoreactivities were detected in Ewing sarcoma tissues obtained from 2 patients with elevated serum ProGRP levels, suggesting that ProGRP is a product of tumor cells of Ewing sarcoma. These results indicate that serum ProGRP could serve as a specific tumor marker for Ewing sarcoma. Since ProGRP is a major hormonal product of tumor cells of small-cell lung carcinoma, a typical neuroendocrine carcinoma, it is reasonable to postulate that the present study provides an evidence for Ewing sarcoma to possess neuroendocrine differentiation.
authors: Shizuoka Cancer Center Hospital.
authors: Ken
authors: K
authors: Yamaguchi
authors: Hirohisa
authors: H
authors: Katagiri
authors: Mitsuru
authors: M
authors: Takahashi
authors: Yuji
authors: Y
authors: Ishida
authors: Akira
authors: A
authors: Ono
authors: Toshiaki
authors: T
authors: Takahashi
authors: Keiichi
authors: K
authors: Ohshima
authors: Tohru
authors: T
authors: Mochizuki
authors: Kenichi
authors: K
authors: Urakami
authors: Koji
authors: K
authors: Muramatsu
authors: Toru
authors: T
authors: Kameya
authors: Ichiro
authors: I
authors: Ito
authors: Takashi
authors: T
authors: Nakajima
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor; D001859:Bone Neoplasms / Q000097:blood* / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood* / Q000378:metabolism; D011994:Recombinant Proteins / Q000097:blood / Q000378:metabolism; D012512:Sarcoma, Ewing / Q000097:blood* / Q000378:metabolism; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D010446:Peptide Fragments; D011994:Recombinant Proteins; C087079:pro-gastrin-releasing peptide (31-98)