title: Effect of vaginal infiltration with ornipressin or saline on intraoperative blood loss during vaginal prolapse surgery: a randomised controlled trial.
abstract: OBJECTIVE
  Hydrodissection incorporating different types of vasoconstrictors is commonly used in vaginal prolapse surgery. There is little evidence as to whether it adds clinical value or whether it exposes the patient to unnecessary risk. The aim of this study was to compare the effect of a vasoconstrictor compared with saline alone on operative blood loss and cardiovascular parameters in a randomised clinical trial setting.
  
  
  METHODS
  Patients undergoing vaginal prolapse surgery were randomised to an ornipressin (Por-8, Ferring) solution or saline alone for hydrodissection. The surgeon and patient were blinded to the solution used. Operative blood loss was accurately quantified and blood pressure and pulse readings recorded Pre, intra- and postoperatively.
  
  
  RESULTS
  Eighty women were randomised. There was a statistically significant difference in the median blood loss: 35 ml (1-209 ml) in the ornipressin group compared with 81 ml (2-328 ml) in the saline group, p = 0.03. There was no statistically significant difference in the median pre and postoperative blood pressure or pulse rate between groups.
  
  
  CONCLUSIONS
  The use of a vasoconstrictor (ornipressin) resulted in a statistically significant decrease in operative blood loss during vaginal prolapse surgery. This occurred without any significant changes in measured cardiovascular parameters.
authors: Department of Obstetrics and Gynaecology, University of the Free State, Bloemfontein, South Africa. hennew@ufs.ac.za.
authors: Etienne W
authors: http://orcid.org/0000-0001-5535-1770
authors: EW
authors: Henn
authors: Department of Obstetrics and Gynaecology, University of the Free State, Bloemfontein, South Africa.
authors: Thando
authors: T
authors: Nondabula
authors: Department of Obstetrics and Gynaecology, University of the Free State, Bloemfontein, South Africa.
authors: Leonard
authors: L
authors: Juul
mesh_terms: D000282:Administration, Intravaginal; D000368:Aged; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D009951:Ornipressin / Q000008:administration & dosage*; D056887:Pelvic Organ Prolapse / Q000601:surgery
chemical_list: D006490:Hemostatics; D009951:Ornipressin
keywords: Hydrodissection; Ornipressin; Prolapse; Randomised; Surgery