title: (±)-Acortatarinowins A-F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii.
abstract: Three pairs of new 8-O-4'-type dinorneolignan enantiomers, (±)-acortatarinowins A-C (1a/1b-3a/3b), a pair of new 8-O-4'-type (4a/4b) and a pair of rare C7-C8'-type (5a/5b) neolignan enantiomers, (±)-acortatarinowins D and E, and a pair of new furofuran-type lignan enantiomers, (±)-acortatarinowin F (6a/6b), along with two pairs of known lignan enantiomers (7a/7b and 8a/8b), were obtained from the rhizomes of Acorus tatarinowii. The separation of 1-8 by chiral HPLC using a Daicel IC column led to the isolation of eight pairs of enantiomers, 1a/1b-8a/8b, which had variable enantiomeric excess (ee) values of approximately 66, 71, 63, 60, 0, 38, 48, and 75%, respectively. The structures were elucidated by extensive spectroscopic and chemical methods, and their absolute configurations were determined by a combined analysis of single-crystal X-ray diffraction and a modified Mosher's method, assisted by experimental and calculated electronic circular dichroism data. Among them, compounds 1a, 3a, 6b, 8a, and 8b showed weak inhibitory activities against NO production in activated macrophages with IC50 values ranging from 23.3 to 38.0 μM, respectively.
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Yuanyuan
authors: Y
authors: Lu
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Yongbo
authors: Y
authors: Xue
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Junjun
authors: J
authors: Liu
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Guangmin
authors: G
authors: Yao
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Dongyan
authors: D
authors: Li
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Bin
authors: B
authors: Sun
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Jinwen
authors: J
authors: Zhang
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Yanfei
authors: Y
authors: Liu
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Changxing
authors: C
authors: Qi
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Ming
authors: M
authors: Xiang
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Zengwei
authors: Z
authors: Luo
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Guang
authors: G
authors: Du
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, ‡Tongji Hospital Affiliated to Tongji Medical College, and §The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, People's Republic of China.
authors: Yonghui
authors: Y
authors: Zhang
mesh_terms: D029023:Acorus / Q000737:chemistry*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004365:Drugs, Chinese Herbal; D017705:Lignans; D009569:Nitric Oxide