title: Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center.
abstract: OBJECTIVE
  This study aims to document and analyze the central venous catheter (CVC)-related complications in children with hematological diseases who were treated within a single institution.
  
  
  METHODS
  A retrospective investigation was conducted in 106 pediatric patients in whom 203 CVCs were inserted. A total of 175 catheter-related complications occurred in 5 years.
  
  
  RESULTS
  The rates of clinical catheter infections, local catheter infections, venous thromboembolism, bleeding, and mechanical complications were 2.6, 1.1, 0.2, 0.2, and 0.2 per 1000 catheter days. Methicillin-resistant Staphylococcus epidermidis was the predominant infectious organism in blood and catheter cultures. The children with leukemia had a significantly higher frequency of clinical catheter infections (p=0.046). The children who underwent bone marrow transplantation had a significantly lower frequency of clinical catheter infections (p=0.043) and higher frequency of local catheter infections (p=0.003). The children with implanted catheters had a significantly lower frequency of clinical catheter infections (p=0.048). The children with thrombocytopenia had significantly fewer local catheter infections and significantly more clinical catheter infections and catheter-related bleeding (respectively p=0.001, p=0.042, and p=0.024).
  
  
  CONCLUSIONS
  Leukemia, bone marrow transplantation, and thrombocytopenia are risk factors for CVC-associated complications. The relatively higher number of interventions performed via permanent catheters may be responsible for the significantly increased incidence of systemic infections and mechanical injury.
authors: Afyon Kocatepe University Faculty of Medicine Hospital, Department of Pediatrics, Afyonkarahisar, Turkey Phone: +90 (272) 246 33 33 E-mail: drayhanpektas@hotmail.com.
authors: Ayhan
authors: A
authors: Pektaş
authors: Ateş
authors: A
authors: Kara
authors: Aytemiz
authors: A
authors: Gurgey
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D016470:Bacteremia / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D016026:Bone Marrow Transplantation; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D062905:Central Venous Catheters / Q000009:adverse effects* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D016469:Fungemia / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D006402:Hematologic Diseases / Q000453:epidemiology* / Q000628:therapy; D006470:Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D007938:Leukemia / Q000453:epidemiology / Q000628:therapy; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000209:etiology; D013921:Thrombocytopenia / Q000453:epidemiology; D014421:Turkey / Q000453:epidemiology; D054556:Venous Thromboembolism / Q000453:epidemiology / Q000209:etiology*