title: Supramolecular hydrogels constructed by red-light-responsive host-guest interactions for photo-controlled protein release in deep tissue.
abstract: We report a novel red-light-responsive supramolecule. The tetra-ortho-methoxy-substituted azobenzene (mAzo) and β-cyclodextrin (β-CD) spontaneously formed a supramolecular complex. The substituted methoxy groups shifted the responsive wavelength of the azo group to the red light region, which is in the therapeutic window and desirable for biomedical applications. Red light induced the isomerization of mAzo and the disassembly of the mAzo/β-CD supramolecular complex. We synthesized a mAzo-functionalized polymer and a β-CD-functionalized polymer. Mixing the two polymers in an aqueous solution generated a supramolecular hydrogel. Red light irradiation induced a gel-to-sol transition as a result of the disassembly of the mAzo/β-CD complexes. Proteins were loaded in the hydrogel. Red light could control protein release from the hydrogel in tissue due to its deep penetration depth in tissue. We envision the use of red-light-responsive supramolecules for deep-tissue biomedical applications.
authors: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany. wusi@mpip-mainz.mpg.de.
authors: Dongsheng
authors: D
authors: Wang
authors: Manfred
authors: M
authors: Wagner
authors: Hans-Jürgen
authors: HJ
authors: Butt
authors: Si
authors: S
authors: Wu
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000737:chemistry*; D002417:Cattle; D003692:Delayed-Action Preparations / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D007536:Isomerism; D008027:Light; D012710:Serum Albumin, Bovine / Q000008:administration & dosage*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D003692:Delayed-Action Preparations; D047392:beta-Cyclodextrins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012710:Serum Albumin, Bovine; C009850:azobenzene; C031215:betadex