title: Striatal contributions to sensory timing: Voxel-based lesion mapping of electrophysiological markers.
abstract: To achieve precise timing, the brain needs to establish a representation of the temporal structure of sensory input and use this information to generate timely responses. These operations engage the basal ganglia. Current research in this direction is limited by reliance on animal models, motor and/or offline tasks, small sample sizes, the low temporal resolution of functional magnetic resonance imaging, and the study of progressive neurodegeneration. Here, we combine the excellent temporal resolution of electrophysiological potentials with the high spatial resolution of structural neuroimaging to investigate basal ganglia contributions to sensory timing. Chronic-stage lesion patients and healthy controls listened to pure-tone sequences differing exclusively in temporal regularity. Event-related potentials (ERPs) indicate a selective indifference against this manipulation in patients, attributable to the striatal part of the basal ganglia on the basis of a lesion-mapping approach. These findings provide evidence for a crucial contribution of the basal ganglia to basic sensory functioning.
authors: School of Psychological Sciences, University of Manchester, Manchester, United Kingdom; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Electronic address: michael.schwartze@manchester.ac.uk.
authors: Michael
authors: M
authors: Schwartze
authors: Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Language and Aphasia Laboratory, University of Leipzig, Leipzig, Germany.
authors: Anika
authors: A
authors: Stockert
authors: School of Psychological Sciences, University of Manchester, Manchester, United Kingdom; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors: Sonja A
authors: SA
authors: Kotz
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000473:pathology; D001480:Basal Ganglia Diseases / Q000473:pathology* / Q000523:psychology*; D001931:Brain Mapping; D002908:Chronic Disease; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017072:Neostriatum / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000473:pathology* / Q000523:psychology*; D059906:Neuroimaging; D011597:Psychomotor Performance; D012677:Sensation
keywords: Audition; Brain injury; Prediction; Sensory gating; Temporal processing