title: Topical Fluorometholone Versus Diclofenac Sodium in Cases With Perennial Allergic Conjunctivitis.
abstract: OBJECTIVE
  To compare the efficacy of diclofenac sodium (DS) 0.1% and fluorometholone (FL) 0.1% in patients with perennial allergic conjunctivitis.
  
  
  METHODS
  Fluorometholone 0.1% or DS 0.1% eye drops were topically administrated 4 times daily for 4 weeks in patients with perennial allergic conjunctivitis. Assessment was conducted with a 4-point rating scale (0=none, 1=mild, 2=moderate, and 3=severe) for 4 signs and 5 symptoms.
  
  
  RESULTS
  Two hundred sixty-one patients were recruited. The demographics and baseline skin prick scores between both groups were comparable. Mean baseline scores in DS and FL group were 6.77 ± 2.24 and 6.34 ± 2.10, respectively. The scores rapidly decreased to 3.28 ± 1.47 and 2.69 ± 1.44 on day 7. Diclofenac sodium expressed a slower effect compared with FL within the first 3 days of treatment (P=0.01).
  
  
  CONCLUSIONS
  The efficacy of topical FL and DS was comparable for the management of cases with perennial allergic conjunctivitis. However, FL led to a more rapid alleviation of signs and symptoms as compared with DS in early days after the initiation of treatment.
authors: Department of Ophthalmology (Z.L., Y.Z., Z.F., G.M.), Provincial Hospital, Shandong University, Ji'nan, China; Tian'Jin Eye Hospital (W.C.), Tianjin, China; and Department of Visual Sciences and Ophthalmology (V.J.), The Chinese University of Hong Kong, Hong Kong, China.
authors: Zhiwei
authors: Z
authors: Li
authors: Wei
authors: W
authors: Chen
authors: Yong
authors: Y
authors: Zhang
authors: Vishal
authors: V
authors: Jhanji
authors: Zhaoshan
authors: Z
authors: Fan
authors: Guoying
authors: G
authors: Mu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018926:Anti-Allergic Agents / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003233:Conjunctivitis, Allergic / Q000188:drug therapy*; D004008:Diclofenac / Q000008:administration & dosage*; D005260:Female; D005469:Fluorometholone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D009883:Ophthalmic Solutions; D004008:Diclofenac; D005469:Fluorometholone