title: Nano "Chocolate Waffle" for near-IR Responsive Drug Releasing System.
abstract: A majority of the photo-responsive drug-delivery systems that are currently being studied require a complicated synthesis method. Here, we prepare a near-infrared responsive, photothermally controllable, drug-delivery carrier by a simple mixing and extraction process without the incorporation of toxic chemicals. A blend of doxorubicin (DOX), an anticancer drug, and a phase-change material (PCM) are loaded onto the mesoporous structure of silica-coated graphene oxide (GO@MS) to form a waffle-like structure, which is confirmed by various physicochemical analyses. The cytotoxicity of DOX/PCM-loaded GO@MS (DOX/PCM-GO@MS) against HeLa cells is 50 times higher than that of free DOX, and this improved activity can be attributed to the photothermal effectiveness of GO@MS. Additionally, the cytotoxicity and uptake mechanism of the PCM-based material are analyzed by flow cytometry. Taken together, our results suggest an enormous potential for spatio-temporal control in photothermally responsive drug-delivery systems.
authors: Center for Self-assembly and Complexity, Institute of Basic Science (IBS), Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 790784, Korea.
authors: Junseok
authors: J
authors: Lee
authors: School of Integrative Engineering, Chung-Ang University, 84 Heukseok-Ro, Dongjakgu, Seoul, Korea.
authors: Hansoo
authors: H
authors: Park
authors: Center for Self-assembly and Complexity, Institute of Basic Science (IBS), Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 790784, Korea.
authors: Won Jong
authors: WJ
authors: Kim
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000528:radiation effects*; D004058:Diffusion / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage*; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D061986:MCF-7 Cells; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects*; D058726:Nanoconjugates / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010316:Particle Size; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D058726:Nanoconjugates; D004317:Doxorubicin
keywords: drug delivery; graphene oxide; mesoporous silica; nanostructures; photothermal materials