title: Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Aβ(25-35)-Induced Axonal Atrophy.
abstract: Axonal regeneration might contribute to the restoration of damaged neuronal networks and improvement of memory deficits in a murine Alzheimer's disease (AD) model. A search for axonal regenerative drugs was performed to discover novel therapeutic options for AD. In this study, an aqueous extract of Drynaria fortunei rhizomes reversed Aβ25-35-induced axonal atrophy in cultured cortical neurons of mice. Bioassay-guided fractionation of this extract led to the isolation and identification of compounds 1-5. Among them, (2S)-neoeriocitrin (2) and caffeic acid 4-O-glucoside (4) showed significant axonal elongation effects on Aβ25-35-induced atrophy.
authors: Division of Neuromedical Science, Department of Bioscience, and ‡Division of Kampo Pharmaceutics, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
authors: Zhi-You
authors: ZY
authors: Yang
authors: Division of Neuromedical Science, Department of Bioscience, and ‡Division of Kampo Pharmaceutics, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
authors: Tomoharu
authors: T
authors: Kuboyama
authors: Division of Neuromedical Science, Department of Bioscience, and ‡Division of Kampo Pharmaceutics, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
authors: Kohei
authors: K
authors: Kazuma
authors: Division of Neuromedical Science, Department of Bioscience, and ‡Division of Kampo Pharmaceutics, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
authors: Katsuhiro
authors: K
authors: Konno
authors: Division of Neuromedical Science, Department of Bioscience, and ‡Division of Kampo Pharmaceutics, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
authors: Chihiro
authors: C
authors: Tohda
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D001369:Axons / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D029621:Polypodiaceae / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)