title: Porcine survival model to simulate acute upper gastrointestinal bleedings.
abstract: The existing animal models used for the simulation of acute gastrointestinal bleedings are usually non-survival models. We developed and evaluated a new porcine model (domestic pig, German Landrace) in which the animal remains alive and survives the artificial bleeding without any cardiovascular impairment. This consists of a bleeding catheter which is implanted into the stomach, then subcutaneously tunnelled from the abdomen to the neck where it is exteriorized and fixed with sutures. Using the injection of porcine blood, controllable and reproducible acute upper gastrointestinal bleeding can be simulated while maintaining normal gastrointestinal motility and physiology. Depending on the volume of blood applied through the gastric catheter, the bleeding intensity can be varied from traces of blood to a massive haemorrhage. This porcine model could be valuable, e.g. for testing the efficacy of new bleeding diagnostics in large animals before human use.
authors: novineon Healthcare Technology Partners GmbH, Tübingen, Germany Proctological Institute Stuttgart, Stuttgart, Germany ruediger@prosst.de.
authors: Ruediger L
authors: RL
authors: Prosst
authors: novineon Healthcare Technology Partners GmbH, Tübingen, Germany Ovesco Endoscopy AG, Tübingen, Germany Steinbeis University Berlin, IHCI Institute, Tübingen, Germany.
authors: Marc O
authors: MO
authors: Schurr
authors: Ovesco Endoscopy AG, Tübingen, Germany.
authors: Sebastian
authors: S
authors: Schostek
authors: novineon Healthcare Technology Partners GmbH, Tübingen, Germany.
authors: Martina
authors: M
authors: Krautwald
authors: Ovesco Endoscopy AG, Tübingen, Germany Medical Faculty, University of Tübingen, Tübingen, Germany.
authors: Thomas
authors: T
authors: Gottwald
mesh_terms: D000208:Acute Disease; D000818:Animals; D002408:Catheters, Indwelling; D004195:Disease Models, Animal; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000601:surgery*; D013552:Swine / Q000601:surgery*
keywords: bleeding catheter; gastrointestinal bleeding; porcine model; survival model