title: Structure and function of Fic proteins.
abstract: Fic proteins are a family of proteins characterized by the presence of a conserved FIC domain that is involved in the modification of protein substrates by the addition of phosphate-containing compounds, including AMP and other nucleoside monophosphates, phosphocholine and phosphate. Fic proteins are widespread in bacteria, and various pathogenic species secrete Fic proteins as toxins that mediate post-translational modifications of host cell proteins, to interfere with cytoskeletal, trafficking, signalling or translation pathways in the host cell. In this Review, we discuss the current knowledge of the structure, function and regulation of Fic proteins and consider important areas for future research.
authors: Yale University School of Medicine, New Haven, Connecticut 06536, USA.
authors: Craig R
authors: CR
authors: Roy
authors: Laboratoire de Biologie et Pharmacologie Appliquée, Centre National de la Recherche Scientifique-Ecole Normale Supérieure Cachan, 61 Avenue du Président Wilson, 94235 Cachan, France.
authors: Jacqueline
authors: J
authors: Cherfils
mesh_terms: D001419:Bacteria / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D003067:Coenzymes / Q000502:physiology; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000502:physiology; D017434:Protein Structure, Tertiary; D013379:Substrate Specificity / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D003067:Coenzymes; D029968:Escherichia coli Proteins; C482598:fic protein, E coli