title: Fluorescence and reflectance spectral imaging system for a murine mammary window chamber model.
abstract: A spectral imaging system was developed to study the development of breast cancer xenografts in a murine mammary window chamber model. The instrument is configured to work with either a laser to excite fluorescence or a broadband light source for diffuse reflectance imaging. Two applications were demonstrated. First, spectral imaging of fluorescence signals was demonstrated with a GFP-breast cancer tumor and fluorescein injection. Second, based on the principles of broadband reflectance spectroscopy, the instrument was used to monitor dynamic changes of tissue absorbance to yield tissue oxygenation maps at different time points during tumor progression.
authors: University of Arizona, College of Optical Sciences, 1630 E University Blvd., Tucson, AZ 85721, USA ; University of Arizona, Department of Medical Imaging, 1609 N Warren Ave, Tucson, AZ 85724, USA.
authors: Hui Min
authors: HM
authors: Leung
authors: University of Arizona, College of Optical Sciences, 1630 E University Blvd., Tucson, AZ 85721, USA ; University of Arizona, Department of Medical Imaging, 1609 N Warren Ave, Tucson, AZ 85724, USA ; University of Arizona, Department of Biomedical Engineering, 1127 E James E. Rogers Way, Tucson, AZ 85721, USA.
authors: Arthur F
authors: AF
authors: Gmitro
keywords: (110.4234) Multispectral and hyperspectral imaging; (170.0110) Imaging systems; (170.1470) Blood or tissue constituent monitoring; (170.2655) Functional monitoring and imaging; (170.6280) Spectroscopy, fluorescence and luminescence