title: Saccharothrixones A-D, Tetracenomycin-Type Polyketides from the Marine-Derived Actinomycete Saccharothrix sp. 10-10.
abstract: Saccharothrixones A-C (1-3), three new aromatic polyketide seco-tetracenomycins, and saccharothrixone D (4), a new tetracenomycin analogue possessing opposite configurations at all of the stereogenic centers, were isolated from the marine-derived actinomycete Saccharothrix sp. 10-10. Compounds 1-3 represent the first examples of seco-tetracenomycins where the quinone ring B is cleaved and re-formed into a furanone ring. Their structures were elucidated by spectroscopic analyses and ECD calculations. The absolute configuration of 4 was confirmed by single-crystal X-ray diffraction analysis. Saccharothrixone D (4) showed in vitro cytotoxic activity against the HepG2 cancer cell line with an IC50 value of 7.5 μM.
authors: Maoluo
authors: M
authors: Gan
authors: Jiangxi University of Traditional Chinese Medicine , Nanchang, Jiangxi 330004, People's Republic of China.
authors: Bin
authors: B
authors: Liu
authors: Yi
authors: Y
authors: Tan
authors: Qiang
authors: Q
authors: Wang
authors: Hongxia
authors: H
authors: Zhou
authors: Hongwei
authors: H
authors: He
authors: Jiangxi University of Traditional Chinese Medicine , Nanchang, Jiangxi 330004, People's Republic of China.
authors: Yuhui
authors: Y
authors: Ping
authors: Zhaoyong
authors: Z
authors: Yang
authors: Yiguang
authors: Y
authors: Wang
authors: Chunling
authors: C
authors: Xiao
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009279:Naphthacenes; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D009279:Naphthacenes; D061065:Polyketides; C000603543:saccharothrixone D; C080889:5838 DNI