title: Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma.
abstract: OBJECTIVE
  Developmental pathways such as Wnt and Notch are involved in different cellular functions from the cell cycle regulation to self-renewal. Therefore, aberrations in these pathways may cause tumorigenesis. Msi1 has a critical regulatory role for the Wnt and Notch pathways. In the present study, we have assessed the probable correlation between the Msi1 and MAML1 in esophageal squamous cell carcinoma (ESCC) progression and metastasis.
  
  
  METHODS
  Levels of Msi1 and MAML1 mRNA expression in 51 ESCC patients were compared to the normal tissues using real-time polymerase chain reaction (PCR).
  
  
  RESULTS
  Nine out of 51 (17.6 %) cases had Msi1/MAML1 overexpression, and there was a significant correlation between such overexpressed cases and tumor location (p = 0.013).
  
  
  CONCLUSIONS
  We showed that there is not any direct correlation and feedback between the Msi1 and MAML1 in ESCC patients.
authors: Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Meysam
authors: M
authors: Moghbeli
authors: Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
authors: Mohammad Mahdi
authors: MM
authors: Forghanifard
authors: Cardiothoracic Surgery and Transplant Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Ali
authors: A
authors: Sadrizadeh
authors: Department of Gastroenterology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Hooman Mosannen
authors: HM
authors: Mozaffari
authors: Department of Anesthesiology and Critical Care, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Ebrahim
authors: E
authors: Golmakani
authors: Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. AbbaszadeganMR@mums.ac.ir.|Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran. AbbaszadeganMR@mums.ac.ir.
authors: Mohammad Reza
authors: MR
authors: Abbaszadegan
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D016601:RNA-Binding Proteins / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D051880:Receptors, Notch / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C430872:MAML1 protein, human; C491297:MSI1 protein, human; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D051880:Receptors, Notch; D014157:Transcription Factors
keywords: Cancer stem cell; Gene expression; Inhibitor; Real time PCR; Signaling pathway; Translation