title: Cytokine-induced killer cells as immunotherapy for solid tumors: current evidence and perspectives.
abstract: Cytokine-induced killer (CIK) cells are ex vivo expanded T lymphocytes endowed with potent MHC-independent antitumor activity. CIK cells are emerging as promising therapeutic approach in the field of cancer adoptive immunotherapy, with biologic features favoring their transferability into clinical applications. Aim of this review is to present the biologic characteristic of CIK cells, discussing the main preclinical findings and initial clinical applications in the field of solid tumors.
authors: Department of Oncology, University of Torino, Turin, Italy.|Laboratory of Medical Oncology, Experimental Cell Therapy, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy.
authors: Lidia
authors: L
authors: Giraudo
authors: Laboratory of Medical Oncology, Experimental Cell Therapy, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy.
authors: Loretta
authors: L
authors: Gammaitoni
authors: Laboratory of Medical Oncology, Experimental Cell Therapy, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy.
authors: Michela
authors: M
authors: Cangemi
authors: Laboratory of Medical Oncology, Experimental Cell Therapy, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy.
authors: Ramona
authors: R
authors: Rotolo
authors: Department of Oncology, University of Torino, Turin, Italy.|Division & Laboratory of Medical Oncology, Candiolo Cancer Institute FPO- IRCCS, Candiolo, Turin, Italy.
authors: Massimo
authors: M
authors: Aglietta
authors: Department of Oncology, University of Torino, Turin, Italy.|Laboratory of Medical Oncology, Experimental Cell Therapy, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy.
authors: Dario
authors: D
authors: Sangiolo
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D055612:Cytokine-Induced Killer Cells / Q000276:immunology* / Q000637:transplantation; D004195:Disease Models, Animal; D006801:Humans; D016219:Immunotherapy, Adoptive; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
chemical_list: C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K
keywords: adoptive immunotherapy; cytokine-induced killer cells; solid tumors