title: Interleukin-17 levels correlate with poor prognosis and vascular endothelial growth factor concentration in the serum of patients with non-small cell lung cancer.
abstract: OBJECTIVE
  The aim of this study was to explore the clinical role of serum interleukin-17 in patients with non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  IL-17 expression and microvessel density (MVD) were measured via immunohistochemistry in 58 NSCLC tissues. Serum IL-17 and VEGF levels in NSCLC patients (n = 43) and healthy controls (n = 37) were analyzed via enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum IL-17 was elevated and the levels positively correlated with VEGF concentration in NSCLC patients. Multivariate analyses revealed that serum IL-17 levels were an independent prognostic factor in NSCLC.
  
  
  CONCLUSIONS
  IL-17 may play a role in NSCLC progression by promoting angiogenesis.
authors: a Department of Medical Oncology , Harbin Medical University Cancer Hospital , Harbin , P.R. China .
authors: Bo
authors: B
authors: Pan
authors: Dehai
authors: D
authors: Che
authors: Jingyan
authors: J
authors: Cao
authors: Jing
authors: J
authors: Shen
authors: Shi
authors: S
authors: Jin
authors: Yongxu
authors: Y
authors: Zhou
authors: Fang
authors: F
authors: Liu
authors: Kuo
authors: K
authors: Gu
authors: Yingchun
authors: Y
authors: Man
authors: Lihua
authors: L
authors: Shang
authors: Yan
authors: Y
authors: Yu
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000098:blood supply / Q000188:drug therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000097:blood*; D053208:Kaplan-Meier Estimate; D016014:Linear Models; D008175:Lung Neoplasms / Q000097:blood* / Q000098:blood supply / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D055806:Microvessels / Q000187:drug effects / Q000378:metabolism; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D018952:Antigens, CD34; C508717:IL17A protein, human; D020381:Interleukin-17; D042461:Vascular Endothelial Growth Factor A
keywords: Angiogenesis; IL-17; VEGF; non-small cell lung cancer; prognosis