title: Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes.
abstract: Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.
authors: Faculty of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 15771, Athens, Greece.
authors: Ioanna
authors: I
authors: Andreadou
authors: Efstathios K
authors: EK
authors: Iliodromitis
authors: Csaba
authors: C
authors: Szabo
authors: Andreas
authors: A
authors: Papapetropoulos
mesh_terms: D000818:Animals; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017869:Cyclic GMP-Dependent Protein Kinases; D006862:Hydrogen Sulfide