title: Autologous Stem Cell Therapy: How Aging and Chronic Diseases Affect Stem and Progenitor Cells.
abstract: During recent years different types of adult stem/progenitor cells have been successfully applied for the treatment of many pathologies, including cardiovascular diseases. The regenerative potential of these cells is considered to be due to their high proliferation and differentiation capacities, paracrine activity, and immunologic privilege. However, therapeutic efficacy of the autologous stem/progenitor cells for most clinical applications remains modest, possibly because of the attenuation of their regenerative potential in aged patients with chronic diseases such as cardiovascular diseases and metabolic disorders. In this review we will discuss the risk factors affecting the therapeutic potential of adult stem/progenitor cells as well as the main approaches to mitigating them using the methods of regenerative medicine.
authors: Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University , Moscow, Russian Federation .
authors: Anastasia Yu
authors: AY
authors: Efimenko
authors: Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University , Moscow, Russian Federation .
authors: Tatiana N
authors: TN
authors: Kochegura
authors: Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University , Moscow, Russian Federation .
authors: Zhanna A
authors: ZA
authors: Akopyan
authors: Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University , Moscow, Russian Federation . ; Laboratory of Angiogenesis, Russian Cardiology Research and Production Complex , Moscow, Russian Federation .
authors: Yelena V
authors: YV
authors: Parfyonova