title: Serum microRNA-210 levels in different groups of chronic hepatitis B patients.
abstract: BACKGROUND
  It has been reported that hepatitis B virus (HBV) replication can be suppressed by microRNA-210 (miR-210). However, whether serum miR-210 levels can serve as disease parameters in patients with chronic hepatitis B (CHB) remains unclear.
  
  
  METHODS
  Serum miR-210 levels were quantified in 115 CHB patients and 20 healthy controls by real-time PCR.
  
  
  RESULTS
  We found that serum miR-210 levels can discriminate the different groups of CHB patients from healthy control (P<0.05), as well as patients with HBe antigen positive from those with HBe antigen negative (P<0.05). Serum miR-210 levels correlated with HBV DNA and HBs antigen (r=0.525, P<0.001 and r=0.348, P<0.001). Notably, inactive carrier patients with high (>3500 IU/mL) or low (<3500 IU/mL) levels of HBs antigen were differentiated by serum miR-210 levels (P<0.05). Moreover, serum miR-210 levels correlated with liver inflammatory activity markers including alanine aminotransferase (ALT) and HAI score. However, there was no correlation of serum miR-210 levels with parameters of liver function including serum albumin, international normalized ratio and bilirubin, as well as the stages of liver fibrosis.
  
  
  CONCLUSIONS
  Serum miR-210 can be used as an indicator of HBV replication and translation, and a potential marker of necroinflammation in patients with CHB.
authors: Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Fujun
authors: F
authors: Yu
authors: Department of Children's internal medicine, The Second Affiliated Hospital & Yuying Children's hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Jianhuan
authors: J
authors: Yang
authors: Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Jinsheng
authors: J
authors: Ouyang
authors: Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Yihu
authors: Y
authors: Zheng
authors: Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Bicheng
authors: B
authors: Chen
authors: Department of Hepatology, Ningbo Yinzhou Second Hospital, Ningbo 315000, PR China.
authors: Guojun
authors: G
authors: Li
authors: Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Zhongqiu
authors: Z
authors: Lu
authors: Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China. Electronic address: dongpeihong111@163.com.
authors: Peihong
authors: P
authors: Dong
authors: Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China. Electronic address: 120378196@qq.com.
authors: Jianjian
authors: J
authors: Zheng
mesh_terms: D000328:Adult; D000956:Antigens, Viral / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D018450:Disease Progression; D005260:Female; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000821:virology; D006801:Humans; D008099:Liver / Q000293:injuries / Q000503:physiopathology / Q000821:virology; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D012306:Risk; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral; D015415:Biomarkers; D004279:DNA, Viral; C543800:MIRN210 microRNA, human; D035683:MicroRNAs
keywords: Chronic hepatitis B; HBV DNA; HBV carrier; HBs antigen; MicroRNA-210