title: Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control.
abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) causes high fever, cough, acute respiratory tract infection and multiorgan dysfunction that may eventually lead to the death of the infected individuals. MERS-CoV is thought to be transmitted to humans through dromedary camels. The occurrence of the virus was first reported in the Middle East and it subsequently spread to several parts of the world. Since 2012, about 1368 infections, including ~487 deaths, have been reported worldwide. Notably, the recent human-to-human 'superspreading' of MERS-CoV in hospitals in South Korea has raised a major global health concern. The fatality rate in MERS-CoV infection is four times higher compared with that of the closely related severe acute respiratory syndrome coronavirus infection. Currently, no drug has been clinically approved to control MERS-CoV infection. In this study, we highlight the potential drug targets that can be used to develop anti-MERS-CoV therapeutics.
authors: Department of Molecular Science and Technology, Ajou University, Suwon, Korea.
authors: Prasannavenkatesh
authors: P
authors: Durai
authors: Department of Molecular Science and Technology, Ajou University, Suwon, Korea.
authors: Maria
authors: M
authors: Batool
authors: Department of Molecular Science and Technology, Ajou University, Suwon, Korea.
authors: Masaud
authors: M
authors: Shah
authors: Department of Molecular Science and Technology, Ajou University, Suwon, Korea.
authors: Sangdun
authors: S
authors: Choi
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D018352:Coronavirus Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000378:metabolism / Q000635:transmission*; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D004196:Disease Outbreaks; D055808:Drug Discovery; D054884:Host-Pathogen Interactions / Q000187:drug effects; D006801:Humans; D065207:Middle East Respiratory Syndrome Coronavirus / Q000187:drug effects / Q000502:physiology*; D058990:Molecular Targeted Therapy; D064370:Spike Glycoprotein, Coronavirus / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D064370:Spike Glycoprotein, Coronavirus; D018819:Dipeptidyl Peptidase 4