title: Premature ventricular contraction-induced cardiomyopathy: Related clinical and electrophysiologic parameters.
abstract: BACKGROUND
  Factors associated with premature ventricular contraction-induced cardiomyopathy (PVCi-CMP) remain debated.
  
  
  OBJECTIVE
  The purpose of this study was to test the correlation of various factors to the presence PVCi-CMP in a large multicenter population.
  
  
  METHODS
  One hundred sixty-eight consecutive patients referred for ablation of frequent premature ventricular contractions (PVCs) were included. Patients were divided into 2 groups: group 1 with suspected PVCi-CMP (96 patients, ejection fraction 38% ± 10%, left ventricular end-diastolic diameter 62 ± 8 mm, with or without additional structural heart disease); and group 2 (control group, 72 patients with normal ejection fraction and left ventricular dimensions). Various clinical and electrophysiologic parameters were compared between groups.
  
  
  RESULTS
  In univariate analysis, left ventricular origin of PVC, lack of palpitations, long PVC coupling interval, epicardial origin of the focus, long sinus beat QRS duration, male gender, high PVC burden, presence of polymorphic PVCs, high PVC QRS duration, and older age were significantly related to the presence of PVCi-CMP. In multivariate analysis, only lack of palpitations, PVC burden, and epicardial origin remained significantly and independently correlated with the presence of cardiomyopathy. Even if sinus QRS duration or PVC left ventricular origin were also found independently linked to PVCi-CMP in the whole population, they were no longer correlated when patients with additional heart disease were excluded.
  
  
  CONCLUSIONS
  Lack of palpitations, PVC burden, and epicardial origin are independent factors that identify patients prone to developing PVCi-CMP.
authors: University Hospital Rangueil, Toulouse, France.
authors: Marie
authors: M
authors: Sadron Blaye-Felice
authors: University Hospital Mondor, Paris, France.
authors: David
authors: D
authors: Hamon
authors: University Hospital Haut-Leveque, Bordeaux-Pessac, France.
authors: Frédéric
authors: F
authors: Sacher
authors: CHUV, Lausanne, Switzerland.
authors: Patrizio
authors: P
authors: Pascale
authors: University Hospital Rangueil, Toulouse, France.
authors: Anne
authors: A
authors: Rollin
authors: University Hospital Rangueil, Toulouse, France.
authors: Alexandre
authors: A
authors: Duparc
authors: University Hospital Rangueil, Toulouse, France.
authors: Pierre
authors: P
authors: Mondoly
authors: University Hospital Haut-Leveque, Bordeaux-Pessac, France.
authors: Nicolas
authors: N
authors: Derval
authors: University Hospital Haut-Leveque, Bordeaux-Pessac, France.
authors: Arnaud
authors: A
authors: Denis
authors: University Hospital Rangueil, Toulouse, France.
authors: Christelle
authors: C
authors: Cardin
authors: University Hospital Haut-Leveque, Bordeaux-Pessac, France.
authors: Mélèze
authors: M
authors: Hocini
authors: University Hospital Haut-Leveque, Bordeaux-Pessac, France.
authors: Pierre
authors: P
authors: Jaïs
authors: CHUV, Lausanne, Switzerland.
authors: Jürg
authors: J
authors: Schlaepfer
authors: University Hospital Rangueil, Toulouse, France.
authors: Vanina
authors: V
authors: Bongard
authors: University Hospital Rangueil, Toulouse, France.
authors: Didier
authors: D
authors: Carrié
authors: University Hospital Rangueil, Toulouse, France.
authors: Michel
authors: M
authors: Galinier
authors: CHUV, Lausanne, Switzerland.
authors: Etienne
authors: E
authors: Pruvot
authors: University Hospital Mondor, Paris, France.
authors: Nicolas
authors: N
authors: Lellouche
authors: University Hospital Haut-Leveque, Bordeaux-Pessac, France.
authors: Michel
authors: M
authors: Haïssaguerre
authors: University Hospital Rangueil, Toulouse, France. Electronic address: mauryjphil@hotmail.com.
authors: Philippe
authors: P
authors: Maury
mesh_terms: D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D017115:Catheter Ablation / Q000379:methods*; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013223:Statistics as Topic; D013318:Stroke Volume; D018879:Ventricular Premature Complexes / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery
keywords: Cardiomyopathy; Premature ventricular contraction; Radiofrequency ablation; Tachycardia-induced cardiomyopathy