title: Photoinduced cytotoxicity by a platinum diimine complex employing magnetite-silica nanocomposites as delivery vehicles.
abstract: Tartaric acid-modified core-shell magnetite-silica nanocomposites were prepared by a sol-gel method, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy and dynamic light scattering. Then the nanocomposites were employed as carriers of a photoactive platinum diimine complex. Photoinduced cytotoxicity by the photosensitizer-loaded nanocomposites in different human carcinoma cells has been studied by cell viability assay. The results suggest that the as-synthesized nanocomposites have good stability in water, and the cytotoxicity induced by the platinum diimine complex in red light can be significantly enhanced when the photosensitizer is loaded with the magnetic nanocomposites.
authors: Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, Shanxi, China. zgzhang@sxu.edu.cn.
authors: Zhigang
authors: Z
authors: Zhang
authors: Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, Shanxi, China.
authors: Haisha
authors: H
authors: Li
authors: Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, Shanxi, China.
authors: Ruihui
authors: R
authors: Dai
authors: Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, Shanxi, China.
authors: Aiyun
authors: A
authors: Chai
mesh_terms: D002277:Carcinoma / Q000188:drug therapy*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D000067493:Dynamic Light Scattering; D052203:Ferrosoferric Oxide / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008027:Light; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000008:administration & dosage / Q000737:chemistry*; D017319:Photosensitizing Agents; D010984:Platinum / Q000008:administration & dosage / Q000737:chemistry*; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013644:Tartrates / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D017319:Photosensitizing Agents; D013644:Tartrates; D010984:Platinum; D012822:Silicon Dioxide; C029768:tartaric acid; D052203:Ferrosoferric Oxide
keywords: Cytotoxicity; HepG2 cells; MCF-7 cells.; Magnetite–silica nanoparticles; Photodynamic therapy