title: [Crosstalk between Wnt5a and inflammatory signaling in inflammation].
abstract: Wnt5a belongs to the large WNT family of cysteine-rich secreted glycoproteins, which is involved in multiple signaling pathways that regulate a variety of cellular processes, including cell motility, proliferation differentiation and so on during development. The regulation and signaling transduction of Wnt5a have been reported to closely relate to inflammatory response, which indicates that Wnt5a plays a critical role in the occurrence and development of inflammatory diseases. In this review, we summarized data on Wnt5a and its signaling pathway, as well as their involvement in inflammatory response. Further comprehensive understanding of the function and relationship between Wnt5a and inflammatory response would help us to develop novel diagnostic and therapeutic strategies for prevention and treatment of inflammatory diseases.
authors: Institute of Pharmacology and Pharmacy, University of South China, Hengyang 421001, China.
authors: Zheng
authors: Z
authors: Liu
authors: The Second Xiangya Hospital, Central South University, Changsha 410011,China.
authors: Hong-Tao
authors: HT
authors: Wu
authors: Institute of Pharmacology and Pharmacy, University of South China, Hengyang 421001, China.
authors: Ya-Guang
authors: YG
authors: Ni
authors: Institute of Pharmacology and Pharmacy, University of South China, Hengyang 421001, China.
authors: Yan-Tao
authors: YT
authors: Yin
authors: School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
authors: Shun-Xiang
authors: SX
authors: Li
authors: School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
authors: Duan-Fang
authors: DF
authors: Liao
authors: Institute of Pharmacology and Pharmacy, University of South China, Hengyang 421001, China.|School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China. lqin1011@126.com.
authors: Li
authors: L
authors: Qin
mesh_terms: D002454:Cell Differentiation; D002465:Cell Movement; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D000071818:Wnt-5a Protein
chemical_list: D011518:Proto-Oncogene Proteins; C085389:WNT5A protein, human; D051153:Wnt Proteins; D000071818:Wnt-5a Protein