title: The Value of MicroRNA-155 as a Prognostic Factor for Survival in Non-Small Cell Lung Cancer: A Meta-Analysis.
abstract: BACKGROUND
  Recent studies have shown that miR-155 play a positive role in the development of carcinoma. This meta-analysis aimed to identify the role of miR-155 in the survival of non-small cell lung cancer patients.
  
  
  METHODS
  Eligible studies were identified through database searches. Relevant data were extracted from each eligible study to assess the correlation between miR-155 expression and survival in lung carcinoma patients. The hazard ratios (HRs) and 95% confidence intervals (CIs) of the patients' outcomes in relation to miR-155 were calculated. A total of 6 studies were included for this meta-analysis. For overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), and cancer-specific survival (CSS), the combined HRs and 95% CIs were not statistically significant. Additionally, in Asian and America subgroups, greater expression levels of miR-155 were related to poor prognoses for lung cancer (HR 1.71 95% CI: 1.22-2.40, P = 0.002, HR 2.35 95% CI: 1.42-3.89 P = 0.001), while no significant relationship was present in a Europe subgroup (HR 0.75 95%CI: 0.27-2.10, P = 0.587).
  
  
  CONCLUSIONS
  These results suggest that miR-155 expression is not significantly related to non-small cell lung cancer patients except in patients from Asian and America.
authors: Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou province, China.
authors: Fei
authors: F
authors: Wang
authors: Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou province, China.
authors: Jianguo
authors: J
authors: Zhou
authors: Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou province, China.
authors: Yu
authors: Y
authors: Zhang
authors: Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou province, China.
authors: Yi
authors: Y
authors: Wang
authors: Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou province, China.
authors: Long
authors: L
authors: Cheng
authors: Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou province, China.
authors: Yuju
authors: Y
authors: Bai
authors: Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou province, China.
authors: Hu
authors: H
authors: Ma
mesh_terms: D044466:Asian People / Q000235:genetics; D002277:Carcinoma / Q000235:genetics / Q000401:mortality / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D018572:Disease-Free Survival; D005060:Europe; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs