title: Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection.
abstract: Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins' family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces.
authors: Research and Innovation Center, Fondazione E. Mach, via E. Mach 1, San Michele all'Adige (TN) 38010, Italy. lisa.rizzetto@fmach.it.
authors: Lisa
authors: L
authors: Rizzetto
authors: Research and Innovation Center, Fondazione E. Mach, via E. Mach 1, San Michele all'Adige (TN) 38010, Italy. tobias.weil@fmach.it.
authors: Tobias
authors: T
authors: Weil
authors: Research and Innovation Center, Fondazione E. Mach, via E. Mach 1, San Michele all'Adige (TN) 38010, Italy. duccio.cavalieri@fmach.it.|Department of Neuroscience, Psychology, Drug Research and Child Health (Neurofarba), University of Florence, Firenze 50139, Italy. duccio.cavalieri@fmach.it.
authors: Duccio
authors: D
authors: Cavalieri
keywords: C-type lectin receptors; Candida albicans; innate immunity; morphology; pathogen; yeast-hyphae