title: Memantine-induced Myoclonus in a Patient with Alzheimer Disease.
abstract: BACKGROUND
  Myoclonus can be a clinical manifestation of numerous neurodegenerative disorders and an adverse drug reaction to medications used in their treatment.
  
  
  METHODS
  Herein, we report memantine-induced myoclonus in a patient with Alzheimer disease. The myoclonus seen in our patient was generalized (proximal limbs and trunk), present at rest and with action, and stimulus sensitive. A structured evaluation with the Unified Myoclonus Rating Scale showed that the myoclonus had no significant effect on functional capacity. After discontinuation of memantine, myoclonus slowly resolved over the course of several weeks.
  
  
  CONCLUSIONS
  Memantine may cause myoclonus in susceptible individuals.
authors: Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
authors: Aditya A
authors: AA
authors: Murgai
authors: Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
authors: Mark S
authors: MS
authors: LeDoux
keywords: Alzheimer disease; Memantine; adverse drug reaction; myoclonus