title: Cognitive impairment and gray matter volume abnormalities in silent cerebral infarction.
abstract: To investigate the association between cognitive impairment and gray matter volume (GMV) abnormalities in silent cerebral infarction (SCI) patients, the GMV of 62 pairs of patients and well-matched healthy controls was calculated. All participants underwent a P300 test, a Montreal Cognitive Assessment (MoCA) test. Compared with controls, the patients showed decreased GMV in the left superior frontal gyrus, left inferior frontal gyrus, left superior temporal gyrus, right middle temporal gyrus, and bilateral parahippocampal gyrus; no significantly increasing GMV was found. The volumes of the frontal and temporal lobes were positively correlated with the score of the MoCA scale and P300 amplitudes (r≥0.62, P<0.01). The P300 latency was negatively correlated with the volumes of the frontal lobe, the temporal lobe, and the hippocampus (r≤-0.71, P<0.05). No significant correlations between the GMV of the abnormal brain regions and four clinical characteristics in SCI patients were found, suggesting that cognitive deficiency existed in SCI patients and the reduced GMV might contribute to the pathology of cognitive deficiency in SCI patients.
authors: aDepartment of Neurology bBiomedical Engineering Laboratory cDepartment of Radiology dDepartment of Neurosurgery, the First Affiliated Hospital of Yangtze University, Hubei, Jingzhou, People's Republic of China.
authors: Tao
authors: T
authors: Yang
authors: Lan
authors: L
authors: Zhang
authors: Mingqing
authors: M
authors: Xiang
authors: Wei
authors: W
authors: Luo
authors: Jinbai
authors: J
authors: Huang
authors: Maokun
authors: M
authors: Li
authors: Xunbo
authors: X
authors: Xiong
authors: Hua
authors: H
authors: Wang
mesh_terms: D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology