title: Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells.
abstract: OBJECTIVE
  Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells.
  
  
  RESULTS
  In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding residential locations were assessed using geographic information systems. Associations between road proximity and cardiovascular indices were analyzed using generalized linear models. Close proximity (<50 m) to a major roadway was associated with lower income and higher rates of smoking but not C-reactive protein levels. After adjustment for potential confounders, the levels of circulating angiogenic cells in peripheral blood were significantly elevated in people living in close proximity to a major roadway (CD31(+)/AC133(+), AC133(+), CD34(+)/AC133(+), and CD34(+)/45(dim)/AC133(+) cells) and positively associated with road segment distance (CD31(+)/AC133(+), AC133(+), and CD34(+)/AC133(+) cells), traffic intensity (CD31(+)/AC133(+) and AC133(+) cells), and distance-weighted traffic intensity (CD31(+)/34(+)/45(+)/AC133(+) cells).
  
  
  CONCLUSIONS
  Living close to a major roadway is associated with elevated levels of circulating cells positive for the early stem marker AC133(+). This may reflect an increased need for vascular repair. Levels of these cells in peripheral blood may be a sensitive index of cardiovascular injury because of residential proximity to roadways.
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Natasha
authors: N
authors: DeJarnett
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Ray
authors: R
authors: Yeager
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Daniel J
authors: DJ
authors: Conklin
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Jongmin
authors: J
authors: Lee
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Timothy E
authors: TE
authors: O'Toole
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: James
authors: J
authors: McCracken
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Wes
authors: W
authors: Abplanalp
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Sanjay
authors: S
authors: Srivastava
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Daniel W
authors: DW
authors: Riggs
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Ihab
authors: I
authors: Hamzeh
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Stephen
authors: S
authors: Wagner
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Atul
authors: A
authors: Chugh
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Andrew
authors: A
authors: DeFilippis
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Tiffany
authors: T
authors: Ciszewski
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Brad
authors: B
authors: Wyatt
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Carrie
authors: C
authors: Becher
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Deirdre
authors: D
authors: Higdon
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Kenneth S
authors: KS
authors: Ramos
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: David J
authors: DJ
authors: Tollerud
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: John A
authors: JA
authors: Myers
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Shesh N
authors: SN
authors: Rai
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Jasmit
authors: J
authors: Shah
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Nagma
authors: N
authors: Zafar
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Sathya S
authors: SS
authors: Krishnasamy
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
authors: Sumanth D
authors: SD
authors: Prabhu
authors: From the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.) aruni@louisville.edu.
authors: Aruni
authors: A
authors: Bhatnagar
mesh_terms: D000071916:AC133 Antigen; D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D001336:Automobiles; D015415:Biomarkers / Q000097:blood; D002452:Cell Count; D003430:Cross-Sectional Studies; D066026:Endothelial Progenitor Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007629:Kentucky; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D012111:Residence Characteristics; D015854:Up-Regulation; D001335:Vehicle Emissions
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D015415:Biomarkers; D004785:Environmental Pollutants; D006023:Glycoproteins; D018836:Inflammation Mediators; C000606023:PROM1 protein, human; D010455:Peptides; D001335:Vehicle Emissions
keywords: air pollution; cardiovascular diseases; endothelial progenitor cells; epidemiology; risk factors