title: A natural therapeutic approach for the treatment of periodontitis by MK615.
abstract: Periodontitis is a chronic inflammatory disease that affects the tooth-supporting tissues. Gingival fibroblasts are the most abundant cells in periodontal tissues and they participate actively in the host inflammatory response to periodontal pathogens that is known to mediate local tissue destruction in periodontitis. The Japanese apricot, known as Ume in Japanese, has been a traditional Japanese medicine for centuries and is a familiar and commonly consumed food. The health benefits of Ume are widely recognized and have been confirmed in recent studies showing that MK615, an extract of compounds from Ume, has strong anticancer and anti-inflammatory effects. However, the potential role of MK615 in oral health is unknown. We hypothesized that the anti-inflammatory activities of MK615 could be exploited to inhibit the effects of lipopolysaccharide (LPS) produced by periodontal bacterial pathogens, such as Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Here, we show that LPS-induced interleukin (IL)-6 and IL-8 production by gingival fibroblasts was dose-dependently inhibited by MK615. As a potent inhibitor of the inflammatory responses induced by periodontal pathogens, MK615 merits further testing as a therapeutic agent in inflammatory diseases such as periodontitis.
authors: Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors: Yoko
authors: Y
authors: Morimoto-Yamashita
authors: Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors: Yoshiko
authors: Y
authors: Kawakami
authors: Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors: Syoko
authors: S
authors: Tatsuyama
authors: Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors: Keiko
authors: K
authors: Miyashita
authors: Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors: Makiko
authors: M
authors: Emoto
authors: Department of Physiology, Kurume University School of Medicine, Fukuoka, Japan.
authors: Kiyoshi
authors: K
authors: Kikuchi
authors: Department of Engineering, Osaka Institute of Technology, Osaka, Japan.
authors: Ko-ichi
authors: K
authors: Kawahara
authors: Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address: mas-tok@dent.kagoshima-u.ac.jp.
authors: Masayuki
authors: M
authors: Tokuda
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002478:Cells, Cultured; D006801:Humans; D010518:Periodontitis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents