title: The toxic effects of indoor atmospheric fine particulate matter collected from allergic and non-allergic families in Wuhan on mouse peritoneal macrophages.
abstract: Recent studies have shown that fine particulate matter (PM2.5) is associated with multiple adverse health outcomes and PM2.5-induced oxidative stress is now commonly known as a proposed mechanism of PM2.5-mediated toxicity. However, the association between allergic symptoms in children and exposure to PM2.5 has not been fully elucidated, particularly the role of PM2.5 on the indoor environment involved in allergy or non-allergy is unknown. The aim of the present study was to explore whether indoor PM2.5 from the homes of children with allergic symptoms had more increased risks of allergy than that of healthy ones and then compare the toxicity and inflammatory response of them. In this study, indoor PM2.5 was collected from the homes of schoolchildren with allergic symptoms and those of healthy ones respectively, and components of PM2.5 were analyzed. PM2.5-mediated oxidative damage and inflammatory response were further evaluated in mouse peritoneal macrophages based on its effects on the levels of reactive oxygen species accumulation, lipid peroxidation, DNA damage or cytokine production. It seems that oxidative stress may contribute to PM2.5-induced toxicity, and PM2.5 from the allergic indoor environment produced more serious toxic effects and an inflammatory response on mouse peritoneal macrophages than that from a non-allergic indoor environment.
authors: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.
authors: Biao
authors: B
authors: Yan
authors: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.
authors: Jinquan
authors: J
authors: Li
authors: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.
authors: Junhui
authors: J
authors: Guo
authors: College of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, Hubei, China.
authors: Ping
authors: P
authors: Ma
authors: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.
authors: Zhuo
authors: Z
authors: Wu
authors: Air Quality Studies, Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
authors: ZhenHao
authors: Z
authors: Ling
authors: Air Quality Studies, Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
authors: Hai
authors: H
authors: Guo
authors: Department of Architectural & Building Science, Tohoku University, Sendai, Japan.
authors: Yoshino
authors: Y
authors: Hiroshi
authors: Department of Architecture, Kogakuin University, Tokyo, Japan.
authors: U
authors: U
authors: Yanagi
authors: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.
authors: Xu
authors: X
authors: Yang
authors: School of Architecture and Urban Planning, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors: Shengwei
authors: S
authors: Zhu
authors: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.
authors: Mingqing
authors: M
authors: Chen
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D016902:Air Pollution, Indoor; D000818:Animals; D002478:Cells, Cultured; D002648:Child; D002681:China; D004249:DNA Damage / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000032:analysis; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D016209:Interleukin-8 / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D052638:Particulate Matter / Q000633:toxicity*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000393:Air Pollutants; D016209:Interleukin-8; D052638:Particulate Matter; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D005978:Glutathione
keywords: PM2.5; allergy; cytokines; macrophages; oxidative stress