title: Association between XRCC1 Arg399Gln polymorphism and glioma risk in a Chinese population: a case-control study.
abstract: OBJECTIVE
  In China, the incidence rates of glioma tend to be increased, however, the genetic contribution to its etiology is not well-understood. The aim of this study is to evaluate the association of XRCC1 Arg399Gln polymorphism with glioma risk in a Chinese population.
  
  
  METHODS
  We conducted a case-control study on 387 patients with glioma and 400 cancer-free controls between 2004 and 2014. Peripheral blood samples of both groups were processed for DNA extraction and genotyping of the XRCC1 Arg399Gln polymorphism using PCR-RFLP. Comparison of the distribution of Arg399Gln genotypes in the study groups was performed by means of 2-sided contingency tables using the χ(2) test. Hazard ratios (HRs) were estimated by Cox proportional hazard regression model.
  
  
  RESULTS
  When the AA genotype was used as the reference group, the GG genotype was associated with significantly increased risk for glioma (adjusted OR = 3.18, 95% CI = 1.38-3.88; P = 0.017). Under the dominant model of inheritance, the AG + GG genotype was associated with significantly increased risk for glioma (adjusted OR =2.33, 95% CI = 1.12-5.81; P = 0.023). When the A allele was used as the reference group, the G allele was associated with increased glioma risk (adjusted OR, 2.44, 95% CI, 1.76-4.18; P = 0.003).
  
  
  CONCLUSIONS
  Our data suggests that XRCC1 Arg399Gln polymorphism contribute to increased risk of glioma, which may be susceptibility biomarkers for glioma.
authors: Department of Neurosurgery, Qilu Hospital of Shandong University Jinan 250012, China.
authors: Lei
authors: L
authors: Wang
authors: Department of Neurosurgery, Qilu Hospital of Shandong University Jinan 250012, China.
authors: Yu-Quan
authors: YQ
authors: Jiang
authors: Department of Neurosurgery, Qilu Hospital of Shandong University Jinan 250012, China.
authors: Mao-De
authors: MD
authors: Zhou
authors: Department of Neurosurgery, Qilu Hospital of Shandong University Jinan 250012, China.
authors: Zheng
authors: Z
authors: Jiang
keywords: Genetic susceptibility; XRCC1; epidemiology; glioma; molecular