title: Plasma YKL-40 during pregnancy and gestational diabetes mellitus.
abstract: Gestational diabetes mellitus (GDM) is characterised by hyperglycaemia during pregnancy. The clinical circumstances involved in the development of GDM leaves the patient at a high risk of the subsequent development of type 2 diabetes. Plasma levels of the inflammation marker YKL-40 are elevated in type 2 diabetes and correlate with fasting plasma glucose levels and insulin resistance in patients with type 2 diabetes. With the present study we aimed to determine if pregnancy (and associated insulin resistance) with or without GDM affects plasma YKL-40 levels. Plasma from women diagnosed with GDM and healthy normal glucose-tolerant pregnant women (non-GDM) was obtained at the third trimester of pregnancy and again 3-4 months following delivery, and levels of YKL-40 and interleukin 6 (IL-6; known to regulate YKL-40) were measured. Plasma YKL-40 levels were similarly low during pregnancy in both groups and increased significantly after delivery, but remained lower in the GDM group compared with the non-GDM group postpartum. In contrast, plasma IL-6 levels were not affected by pregnancy or diagnosis of GDM, Nevertheless, YKL-40 levels were associated with IL-6 levels in the non-GDM group (but not in the GDM group). Pregnancy seems to be associated with a temporary reduction in circulating YKL-40, which increases after delivery, but to a much lesser extent in women with GDM than in non-GDM women.
authors: The Centre of Inflammation and Metabolism, The Centre for Physical Activity Research, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: rinnov@gmail.com.
authors: Anders R
authors: AR
authors: Rinnov
authors: Department of Endocrinology and Metabolism, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
authors: Camilla N
authors: CN
authors: Rathcke
authors: Center for Diabetes Research, Department of Medicine, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
authors: Lisbeth
authors: L
authors: Bonde
authors: Center for Diabetes Research, Department of Medicine, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
authors: Tina
authors: T
authors: Vilsbøll
authors: Center for Diabetes Research, Department of Medicine, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
authors: Filip K
authors: FK
authors: Knop
mesh_terms: D054392:Adipokines / Q000097:blood* / Q000276:immunology; D000328:Adult; D001786:Blood Glucose / Q000276:immunology / Q000378:metabolism; D000071451:Chitinase-3-Like Protein 1; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology / Q000276:immunology; D016640:Diabetes, Gestational / Q000097:blood* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D037102:Lectins / Q000097:blood* / Q000276:immunology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood* / Q000276:immunology
chemical_list: D054392:Adipokines; D001786:Blood Glucose; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; C508600:IL6 protein, human; D015850:Interleukin-6; D037102:Lectins
keywords: Gestational diabetes mellitus; IL-6; YKL-40