title: Effect of 24-h continuous rotigotine treatment on stationary and non-stationary locomotion in de novo patients with Parkinson disease in an open-label uncontrolled study.
abstract: The aim of this study was to investigate the effect of a rotigotine transdermal patch on stationary and non-stationary locomotion in de novo Parkinson disease (PD) patients in an open-label uncontrolled study. A 3-D gait analysis system was used to investigate four different locomotor tasks: steady-state linear walking, gait initiation, gait termination and 180°-turning. A series of gait variables were measured for each locomotor task. PD patients who received rotigotine treatment (4-8 mg) displayed: (1) increased step length, gait speed, cadence and arm oscillations, and reduced double support duration and step asymmetry during steady-state linear gait; (2) increased initial step length during gait initiation; (3) increased final step length and gait speed, and decreased stability index during gait termination; (4) decreased duration of turning and head-pelvis delays during 180°-turning. The main finding that emerges from the present study is that the dopamine agonist rotigotine can improve various aspects of gait in de novo PD patients.
authors: Department of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, Latina, Italy. mariano.serrao@uniroma1.it.|Rehabilitation Centre, Policlinico Italia, Rome, Italy. mariano.serrao@uniroma1.it.
authors: Mariano
authors: M
authors: Serrao
authors: Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL, Monte Porzio Catone, Rome, Italy.
authors: Alberto
authors: A
authors: Ranavolo
authors: Fondazione Don Gnocchi, Milan, Italy.
authors: Carmela
authors: C
authors: Conte
authors: Department of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, Latina, Italy.
authors: Chiara
authors: C
authors: Davassi
authors: Fondazione Don Gnocchi, Milan, Italy.
authors: Silvia
authors: S
authors: Mari
authors: Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, ON, Canada.
authors: Alfonso
authors: A
authors: Fasano
authors: Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL, Monte Porzio Catone, Rome, Italy.
authors: Giorgia
authors: G
authors: Chini
authors: Department of Neurophysiology of Vision and Neurophthalmology, G.B. Bietti Foundation-IRCCS, Rome, Italy.
authors: Gianluca
authors: G
authors: Coppola
authors: Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL, Monte Porzio Catone, Rome, Italy.
authors: Francesco
authors: F
authors: Draicchio
authors: Department of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, Latina, Italy.|IRCCS Neuromed, Pozzilli, Isernia, Italy.
authors: Francesco
authors: F
authors: Pierelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D020233:Gait Disorders, Neurologic / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000494:pharmacology*; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D018491:Dopamine Agonists; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; C047508:rotigotine
keywords: 3-D gait analysis; De novo Parkinson; Kinematics; Non-stationary locomotion; Rotigotine