title: Surface plasmon resonance imaging of gold-small molecule interactions is influenced by refractive index and chemical structures.
abstract: OBJECTIVE
  We hypothesize that surface plasmon resonance imaging (SPRi) of interactions between small organic compounds and gold is influenced by the refractive index and chemical structures of the compounds.
  
  
  METHODS
  For the first time we imaged the SPR signals upon interaction of a gold surface with seven compounds representing aromatic, cyclic, short chain, and long chain carbon structures using an array format.
  
  
  RESULTS
  The refractive index and chemical structures of the tested compounds influenced the sensitivity of detection of the SPR microarray imager. Thus, the array methodology presented herein is suitable for studying interactions of small molecules with a gold surface.
authors: Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States.
authors: Zainab H
authors: ZH
authors: Al Mubarak
authors: Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
authors: Rajagopal
authors: R
authors: Ramesh
authors: Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, United States.
authors: Lin
authors: L
authors: Liu
authors: Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States. Electronic address: gopan.krishnan@okstate.edu.
authors: Sadagopan
authors: S
authors: Krishnan
mesh_terms: D000327:Adsorption; D002244:Carbon / Q000737:chemistry*; D003952:Diagnostic Imaging / Q000295:instrumentation; D004553:Electric Conductivity; D004784:Environmental Monitoring / Q000295:instrumentation; D004867:Equipment Design; D006046:Gold / Q000737:chemistry*; D057230:Limit of Detection; D008422:Materials Testing; D008970:Molecular Weight; D055096:Optical Devices; D012031:Refractometry; D015203:Reproducibility of Results; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D002244:Carbon; D006046:Gold
keywords: Adsorption; Gold microarray; Refractive index; Small organic compounds; Surface plasmon resonance