title: Predicting the spatial organization of chromosomes using epigenetic data.
abstract: Chromosome folding can reinforce the demarcation between euchromatin and heterochromatin. Two new studies show how epigenetic data, including DNA methylation, can accurately predict chromosome folding in three dimensions. Such computational approaches reinforce the idea of a linkage between epigenetically marked chromatin domains and their segregation into distinct compartments at the megabase scale or topological domains at a higher resolution. Please see related articles: http://dx.doi.org/10.1186/s13059-015-0741-y and http://dx.doi.org/10.1186/s13059-015-0740-z.
authors: Laboratory of Molecular Biology of Eukaryotes (LBME), CNRS - University of Toulouse (UPS), F-31000, Toulouse, France.
authors: Raphaël
authors: R
authors: Mourad
authors: Laboratory of Molecular Biology of Eukaryotes (LBME), CNRS - University of Toulouse (UPS), F-31000, Toulouse, France. cuvier@ibcg.biotoul.fr.
authors: Olivier
authors: O
authors: Cuvier
mesh_terms: D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D042421:Histone Code; D006801:Humans; D008297:Male
chemical_list: D002843:Chromatin