title: Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis.
abstract: The synthesis of potent inhibitors for lacto-N-biosidases and X-ray structural characterization of these compounds in complex with BbLNBase is described.
authors: School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia. keith.stubbs@uwa.edu.au.
authors: Mitchell
authors: M
authors: Hattie
authors: Tasuku
authors: T
authors: Ito
authors: Aleksandra W
authors: AW
authors: Debowski
authors: Takatoshi
authors: T
authors: Arakawa
authors: Takane
authors: T
authors: Katayama
authors: Kenji
authors: K
authors: Yamamoto
authors: Shinya
authors: S
authors: Fushinobu
authors: Keith A
authors: KA
authors: Stubbs
mesh_terms: D001644:Bifidobacterium / Q000201:enzymology; D055162:Biocatalysis; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D054852:Small Molecule Libraries; D006026:Glycoside Hydrolases; C076748:lacto-N-biosidase