title: Vibrational Circular Dichroism Shows Reversible Helical Handedness Switching in Peptidomimetic l-Valine Fibrils.
abstract: We elucidate the supramolecular organization in the form of microsize fibrils of gels formed by a l-Valine peptidomimetic compound. Analysis was based on circular dichroism spectroscopies, vibrational (VCD) and electronic (CD), supported by microscopy (atomic force and scanning electron). We show how the VCD spectra give account of the micrometric structure of the fibrils formed by the helicoidal arrangement of simpler proto-fibrils, which are organized in a lower hierarchical level. This ability is used to monitorize a fully reversible change in the handedness of the helix by modulating different external stimuli as pH or ionic strength, thus providing the first observation by VCD of such a phenomenon in a short peptide.
authors: †Departamento de Química Física, Facultad de Ciencias, Universidad de Málaga, Málaga 29071, Spain.
authors: Belén
authors: B
authors: Nieto-Ortega
authors: ‡Department de Química Inorgànica I Orgànica, Universitat Jaume I, Castellón 12071, Spain.
authors: Vicent J
authors: VJ
authors: Nebot
authors: ‡Department de Química Inorgànica I Orgànica, Universitat Jaume I, Castellón 12071, Spain.
authors: Juan F
authors: JF
authors: Miravet
authors: ‡Department de Química Inorgànica I Orgànica, Universitat Jaume I, Castellón 12071, Spain.
authors: Beatriu
authors: B
authors: Escuder
authors: †Departamento de Química Física, Facultad de Ciencias, Universidad de Málaga, Málaga 29071, Spain.
authors: Juan T López
authors: JT
authors: Navarrete
authors: †Departamento de Química Física, Facultad de Ciencias, Universidad de Málaga, Málaga 29071, Spain.
authors: Juan
authors: J
authors: Casado
authors: †Departamento de Química Física, Facultad de Ciencias, Universidad de Málaga, Málaga 29071, Spain.
authors: Francisco J
authors: FJ
authors: Ramírez
keywords: chirality; circular dichroism; hydrogel; microscopy; peptidomimetic