title: The physiological effects of human immunoglobulin on severe bronchiolitis patients before and after treatment.
abstract: The goal of the present study is to explore the physiological effects of injected human immunoglobulin on patients with severe bronchiolitis before and after treatment. 86 young children with severe bronchiolitis were randomly divided into the observation group (43 cases) and the treatment group (43 cases). On the basis of conventional therapy, the children in the treatment group were given human immunoglobulin (400 mg/kg, 1-3 times) via intravenous injection. 60 healthy young children, as determined by a physical examination given at the Zhumadian Central Hospital, were enrolled as the control group. The T lymphocytes, cytokines, IgA, IgG, and IgM immunoglobulins in the peripheral blood of all 3 groups were measured. The clinical efficacy of the immunoglobulins to mitigate the effects of bronchiolitis and the amount of time for the reduction of symptoms to occur were observed. The serum Ca, Fe, and Zn levels of children with severe bronchiolitis were significantly lower than those of the healthy control group (p < 0.05). As such, the CD8, IgA, IgG, IgM and IFN-γ levels were also significantly lower in the children with severe bronchiolitis than in the children in the healthy control group (p < 0.05). Furthermore, the CD4, IgE, IL-4, and IL-4/IFN-γ levels and CD4/CD8 ratio were dramatically higher than in the healthy control group (p < 0.05). Serum levels of the aforementioned indicators either increased or decreased after IVIG treatment. The amount of time required for coughing, wheezing, and pulmonary rales to seize, and the duration of illness for the children with the severe bronchiolitis children was significantly shorter for those in the treatment group than for those in the observation group. Human immunoglobulin via intravenous injection showed active therapeutical effects on trace elements, T lymphocytes, and cytokines in patients with severe bronchiolitis.
authors: a Intensive Care Unit, Zhumadian Central Hospital ; Zhumadian , Henan Province , China.
authors: Yan-Hua
authors: YH
authors: Shan
authors: a Intensive Care Unit, Zhumadian Central Hospital ; Zhumadian , Henan Province , China.
authors: Yong-Gang
authors: YG
authors: Zhang
authors: b School of Electric Engineering, Zhengzhou University ; Zhengzhou , Henan Province , China.
authors: Jian-Hua
authors: JH
authors: Zhang
authors: a Intensive Care Unit, Zhumadian Central Hospital ; Zhumadian , Henan Province , China.
authors: Dong
authors: D
authors: Wang
authors: a Intensive Care Unit, Zhumadian Central Hospital ; Zhumadian , Henan Province , China.
authors: Xiao-Xia
authors: XX
authors: Li
authors: a Intensive Care Unit, Zhumadian Central Hospital ; Zhumadian , Henan Province , China.
authors: Jie
authors: J
authors: Zhang
authors: a Intensive Care Unit, Zhumadian Central Hospital ; Zhumadian , Henan Province , China.
authors: Xi-Mei
authors: XM
authors: Wang
authors: a Intensive Care Unit, Zhumadian Central Hospital ; Zhumadian , Henan Province , China.
authors: Song-Yuan
authors: SY
authors: Luo
mesh_terms: D001988:Bronchiolitis / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007223:Infant; D008297:Male; D008670:Metals / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D008670:Metals
keywords: IVIG; T cell subsets; clinical symptoms and signs; immunoglobulin; severe bronchiolitis; trace element