title: Association between dietary factors and plasma fetuin-A concentrations in the general population.
abstract: Circulating fetuin-A, a novel marker for hepatic fat accumulation, has been related to a higher risk of type 2 diabetes and cardiovascular diseases in a growing number of prospective studies. However, little is known about dietary determinants of fetuin-A concentrations in the general population. Therefore, we aimed to investigate the association between dietary intake of energy, energy-providing nutrients, alcohol and major food groups and plasma fetuin-A concentrations in the Bavarian Food Consumption Survey II. Dietary intake was assessed by three 24-h dietary recalls, and plasma concentrations of fetuin-A were measured in 558 adults (18-81 years). After multivariable adjustment for lifestyle factors and body fatness, higher energy intake was nonsignificantly associated with higher fetuin-A concentrations (per 2092 kJ/d (500 kcal/d) 3·7 µg/ml, 95 % CI -0·5, 7·8 µg/ml). There was no clear association between energy-providing nutrients and fetuin-A concentrations. Higher alcohol intake was associated with lower fetuin-A concentrations (P trend 0·003): mean fetuin-A concentrations were 324 (95 % CI 313, 335) µg/ml in non-drinkers, and with 293 (95 % CI 281, 306) µg/ml significantly lower in participants who drank ≥30 g alcohol per d. Mean fetuin-A concentrations decreased across quintiles of milk and dairy product intake (lowest quintile 319 (95 % CI 309, 330) µg/ml; highest quintile 304 (95 % CI 293, 314) µg/ml; P trend 0·03), and each 150-g increment in milk/dairy products per d was associated with 5·6 (95 % CI -9·6, -1·5) µg/ml lower fetuin-A. Dietary intakes of vegetables, meat or fish were not associated with fetuin-A concentrations. Because of the preventive potential of our findings, further exploration is warranted.
authors: 1Molecular Epidemiology Research Group,Max Delbrück Center for Molecular Medicine (MDC),13125 Berlin,Germany.
authors: Katharina
authors: K
authors: Nimptsch
authors: 1Molecular Epidemiology Research Group,Max Delbrück Center for Molecular Medicine (MDC),13125 Berlin,Germany.
authors: Jürgen
authors: J
authors: Janke
authors: 1Molecular Epidemiology Research Group,Max Delbrück Center for Molecular Medicine (MDC),13125 Berlin,Germany.
authors: Tobias
authors: T
authors: Pischon
authors: 2Institute of Epidemiology 2,Helmholtz Centre Munich,85764 Neuherberg,Germany.
authors: Jakob
authors: J
authors: Linseisen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood; D003430:Cross-Sectional Studies; D003611:Dairy Products; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D004032:Diet; D002149:Energy Intake; D005260:Female; D005399:Fishes; D006801:Humans; D008019:Life Style; D008297:Male; D011939:Mental Recall; D018977:Micronutrients / Q000008:administration & dosage*; D008875:Middle Aged; D015596:Nutrition Assessment; D000069466:Red Meat; D017747:Seafood; D014675:Vegetables; D055815:Young Adult; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D018977:Micronutrients; D060749:alpha-2-HS-Glycoprotein
keywords: Alcohol; BVS II Bavarian Food Consumption Survey II; Dairy products; Dietary intake; Energy intake; Fetuin-A