title: Review of integrase strand transfer inhibitors for the treatment of human immunodeficiency virus infection.
abstract: Integrase strand transfer inhibitors (INSTIs) are oral antiretroviral agents used against HIV infection. There are three agents available, including raltegravir, elvitegravir and dolutegravir, some of which are available as combination medications with other antiretroviral drugs. The efficacy and safety of INSTIs in treatment-naïve and experienced HIV-infected patients have been established by multiple studies. Based on the current practice guidelines, INSTI-based regimens are considered as one of the first-line therapies for treatment-naïve HIV-infected patients. There are new INSTIs in development to improve the resistance profile and to decrease the frequency of drug administration.
authors: a 1 Fairleigh Dickinson University, School of Pharmacy, 230 Park Avenue, M-SP1-01, Florham Park, NJ 07901, USA.
authors: Tae Eun
authors: TE
authors: Park
authors: a 1 Fairleigh Dickinson University, School of Pharmacy, 230 Park Avenue, M-SP1-01, Florham Park, NJ 07901, USA.
authors: Abdilahi
authors: A
authors: Mohamed
authors: a 1 Fairleigh Dickinson University, School of Pharmacy, 230 Park Avenue, M-SP1-01, Florham Park, NJ 07901, USA.
authors: Julie
authors: J
authors: Kalabalik
authors: b 2 Long Island University Arnold & Marie Schwartz College of Pharmacy and Health Sciences, 450 Clarkson Avenue Box 36, Brooklyn, NY 11203, USA.
authors: Roopali
authors: R
authors: Sharma
mesh_terms: D015658:HIV Infections / Q000188:drug therapy*; D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000627:therapeutic use*; D006801:Humans
chemical_list: D019428:HIV Integrase Inhibitors; D019427:HIV Integrase
keywords: dolutegravir; elvitegravir; human immunodeficiency virus; integrase strand transfer inhibitor; raltegravir