title: ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients.
abstract: OBJECTIVE
  Polymorphisms of the angiotensin converting enzyme (ACE) gene can interfere with exercise-induced acute blood pressure (BP) reduction. This cross-over study investigated the acute effect of a single walk on BP and tested whether polymorphisms of the ACE gene might explain the variation in BP responses.
  
  
  METHODS
  Thirty-four healthy medicated individuals were randomized to one control and one walking session at 60-75% of heart rate reserve. Subjects left the laboratory wearing an ambulatory BP monitor until waking the next morning.
  
  
  RESULTS
  Overall, systolic BP was somewhat lower following the walking session (p=.06), which could be attributed to a consistently lower systolic BP for 5 h after exercise (p-interaction<.04) compared with control rest. Similarly, II/ID individuals had a lower systolic BP (p-interaction=.02) and diastolic BP (p-interaction<.01) for 5 h after walking compared with control rest. Among DD individuals, a single walk did not induce a reduction in BP (p-interaction>.05).
  
  
  CONCLUSIONS
  Our results showed that postexercise hypotension can occur after a walk at moderate intensity in carriers of the I allele; we were not able to demonstrate this in DD individuals. Our results suggest that genetic variation in the ACE gene might affect the BP response to exercise, although more research is needed to confirm these findings.
authors: Research Group of Cardiovascular Response and Exercise, State University of Londrina, Brazil Research Group of Cardiovascular Rehabilitation, Department of Rehabilitation Sciences, KU Leuven, Belgium karlagoessler@gmail.com.
authors: Karla F
authors: KF
authors: Goessler
authors: Research Group of Cardiovascular Rehabilitation, Department of Rehabilitation Sciences, KU Leuven, Belgium.
authors: Véronique A
authors: VA
authors: Cornelissen
authors: School of Physical Education and Sport, University of São Paulo, Brazil.
authors: Edilamar M
authors: EM
authors: de Oliveira
authors: School of Physical Education and Sport, University of São Paulo, Brazil.
authors: Glória
authors: G
authors: de F Mota
authors: Research Group of Cardiovascular Response and Exercise, State University of Londrina, Brazil.
authors: Marcos D
authors: MD
authors: Polito
mesh_terms: D001794:Blood Pressure / Q000235:genetics*; D003971:Diastole; D004587:Electrophoresis, Agar Gel; D015444:Exercise; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D013599:Systole; D016138:Walking
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Ambulatory blood pressure monitoring; aerobic exercise; genetic polymorphisms; postexercise hypotension; renin-angiotensin-aldosterone system