title: Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study.
abstract: Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of cardiovascular calcification. However several factors can promote or inhibit the natural process of pathological calcification. This cross-sectional study evaluated the relationship between physiological levels of urinary phytate and heart valve calcification in a population of elderly out subjects. A population of 188 elderly subjects (mean age: 68 years) was studied. Valve calcification was measured by echocardiography. Phytate determination was performed from a urine sample and data on blood chemistry, end-systolic volume, concomitant diseases, cardiovascular risk factors, medication usage and food were obtained. The study population was classified in three tertiles according to level of urinary phytate: low (<0.610 μM), intermediate (0.61-1.21 μM), and high (>1.21 μM). Subjects with higher levels of urinary phytate had less mitral annulus calcification and were less likely to have diabetes and hypercholesterolemia. In the multivariate analysis, age, serum phosphorous, leukocytes total count and urinary phytate excretion appeared as independent factors predictive of presence of mitral annulus calcification. There was an inverse correlation between urinary phytate content and mitral annulus calcification in our population of elderly out subjects. These results suggest that consumption of phytate-rich foods may help to prevent cardiovascular calcification evolution.
authors: IdISPa, Hospital Universitario Son Espases, 07120, Palma of Mallorca, Spain.
authors: Carlos
authors: C
authors: Fernández-Palomeque
authors: IdISPa, Hospital Universitario Son Espases, 07120, Palma of Mallorca, Spain.
authors: Andres
authors: A
authors: Grau
authors: Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS- IdISPa), University of Balearic Islands, 07122, Palma of Mallorca, Spain.
authors: Joan
authors: J
authors: Perelló
authors: Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS- IdISPa), University of Balearic Islands, 07122, Palma of Mallorca, Spain.
authors: Pilar
authors: P
authors: Sanchis
authors: Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS- IdISPa), University of Balearic Islands, 07122, Palma of Mallorca, Spain.
authors: Bernat
authors: B
authors: Isern
authors: Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS- IdISPa), University of Balearic Islands, 07122, Palma of Mallorca, Spain; CIBERobn (CB06/03), Instituto de Salud Carlos III, 28029, Madrid, Spain.
authors: Rafel M
authors: RM
authors: Prieto
authors: Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS- IdISPa), University of Balearic Islands, 07122, Palma of Mallorca, Spain; CIBERobn (CB06/03), Instituto de Salud Carlos III, 28029, Madrid, Spain.
authors: Antonia
authors: A
authors: Costa-Bauzá
authors: IdISPa, Hospital Universitario Son Espases, 07120, Palma of Mallorca, Spain.
authors: Onofre J
authors: OJ
authors: Caldés
authors: IdISPa, Hospital Universitario Son Espases, 07120, Palma of Mallorca, Spain.
authors: Oriol
authors: O
authors: Bonnin
authors: IdISPa, Hospital Universitario Son Espases, 07120, Palma of Mallorca, Spain.
authors: Ana
authors: A
authors: Garcia-Raja
authors: IdISPa, Hospital Universitario Son Espases, 07120, Palma of Mallorca, Spain.
authors: Armando
authors: A
authors: Bethencourt
authors: Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS- IdISPa), University of Balearic Islands, 07122, Palma of Mallorca, Spain; CIBERobn (CB06/03), Instituto de Salud Carlos III, 28029, Madrid, Spain.
authors: Felix
authors: F
authors: Grases
mesh_terms: D000368:Aged; D000375:Aging; D002113:Calcification, Physiologic; D002114:Calcinosis / Q000097:blood / Q000652:urine*; D009202:Cardiomyopathies / Q000097:blood / Q000453:epidemiology / Q000652:urine*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D017886:Durapatite / Q000378:metabolism; D004452:Echocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000453:epidemiology / Q000652:urine*; D006351:Heart Valves / Q000473:pathology*; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D007958:Leukocyte Count; D008297:Male; D008943:Mitral Valve / Q000473:pathology; D010710:Phosphates / Q000097:blood; D010833:Phytic Acid / Q000652:urine*; D012307:Risk Factors
chemical_list: D010710:Phosphates; D010833:Phytic Acid; D017886:Durapatite