title: Acute Myeloid Leukemia With t(v;5q33) Is Associated With Poor Overall Survival and Often Lacks Myelodysplastic Features.
abstract: BACKGROUND
  Acute myeloid leukemia (AML) with specific balanced 5q33 translocations are classified as AML with myelodysplasia-related changes regardless of their morphologic findings or antecedent hematologic disease, but the clinicopathologic features of such cases remain poorly understood.
  
  
  METHODS
  From > 2000 cases of hematological malignancies seen at our institution between 2000 and 2013, we identified 9 AML patients with 5q33 translocations with variable partner loci, t(v;5q33).
  
  
  RESULTS
  The study group included 8 men and 1 woman, with a median age of 64 years (range, 19-87 years). Four patients had an antecedent myeloproliferative neoplasm (MPN). Cytogenetic analysis showed t(v;5q33) as a sole chromosomal abnormality in 4 (44%) patients, t(v;5q33) and del(3)(q21;q26.2) in 1 (11%) patient, and a complex karyotype in 4 (44%) patients. Only 1 patient had morphologic features of myelodysplasia in 2 or more lineages. Follow-up was available for 7 patients and the median overall survival (OS) was 12 months. Patients with a history of MPN had a significantly shorter OS compared with those with de novo AML (11 vs. 20 months; P = .0445). There was no correlation between complex karyotype and OS in this small group of AML patients (P = .5904).
  
  
  CONCLUSIONS
  The t(v;5q33) is a rare cytogenetic aberration in AML. Although associated with a poor outcome, AML with t(v;5q33) usually lacks morphologic evidence of multilineage dysplasia. Patients who have AML with t(v;5q33) after MPN have a worse OS compared with those with de novo AML.
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Mariko
authors: M
authors: Yabe
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Guilin
authors: G
authors: Tang
authors: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Guillermo
authors: G
authors: Garcia-Manero
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Sanam
authors: S
authors: Loghavi
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Xinyan
authors: X
authors: Lu
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Roberto N
authors: RN
authors: Miranda
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: L Jeffrey
authors: LJ
authors: Medeiros
authors: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Hagop M
authors: HM
authors: Kantarjian
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Carlos E
authors: CE
authors: Bueso-Ramos
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address: jkhoury@mdanderson.org.
authors: Joseph D
authors: JD
authors: Khoury
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020732:Cytogenetic Analysis / Q000379:methods*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000235:genetics*; D011379:Prognosis; D016019:Survival Analysis; D014178:Translocation, Genetic / Q000235:genetics*; D055815:Young Adult
keywords: Acute myeloid leukemia; Balanced translocation; Chromosome 5q; Cytogenetics; Myelodysplasia-related changes