title: Polyethylene glycol versus sodium picosulfalte bowel preparation in the setting of a colorectal cancer screening program.
abstract: BACKGROUND
  Adequate bowel preparation for colonoscopy is an important predictor of colonoscopy quality.
  
  
  OBJECTIVE
  To determine the difference in terms of effectiveness between different existing colon cleansing products in the setting of a colorectal cancer screening program.
  
  
  METHODS
  The records of consecutive patients who underwent colonoscopy at the Montreal General Hospital (Montreal, Quebec) between April 2013 and April 2014 were retrospectively extracted from a dedicated electronic digestive endoscopic institutional database.
  
  
  RESULTS
  Overall, 2867 charts of patients undergoing colonoscopy were assessed, of which 1130 colonoscopies were performed in a screening setting; patients had adequate bowel preparation in 90%. Quality of preparation was documented in only 61%. Bowel preparation was worse in patients receiving sodium picosulfate (PICO) alone compared with polyethylene glycol, in a screening setting (OR 0.3 [95% CI 0.2 to 0.6]). Regardless of the preparation type, the odds of achieving adequate quality cleansing was 6.6 for patients receiving a split-dose regimen (OR 6.6 [95% CI 2.1 to 21.1]). In multivariable analyses, clinical variables associated with inadequate bowel preparation in combined population were use of PICO, a nonsplit regimen and inpatient status. The polyp detection rate was very high (45.6%) and was correlated with withdrawal time.
  
  
  CONCLUSIONS
  Preparation quality needs to be more consistently included in the colonoscopy report. Split-dose regimens increased the quality of colon cleansing across all types of preparations and should be the preferred method of administration. Polyethylene glycol alone provided better bowel cleansing efficacy than PICO in a screening setting but PICO remains an alternative in association with an adjuvant.
authors: Omar
authors: O
authors: Kherad
authors: Sophie
authors: S
authors: Restellini
authors: Myriam
authors: M
authors: Martel
authors: Alan N
authors: AN
authors: Barkun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002400:Cathartics / Q000008:administration & dosage*; D002951:Citrates / Q000008:administration & dosage*; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003111:Colonic Polyps / Q000175:diagnosis; D003113:Colonoscopy / Q000706:statistics & numerical data*; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D015999:Multivariate Analysis; D009942:Organometallic Compounds / Q000008:administration & dosage*; D010847:Picolines / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011300:Preoperative Care / Q000379:methods; D011792:Quebec; D012189:Retrospective Studies; D012997:Solvents / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D002400:Cathartics; D002951:Citrates; D009942:Organometallic Compounds; D010847:Picolines; D012997:Solvents; D011092:Polyethylene Glycols; C005701:picosulfate sodium