title: The Association Between Sjögren Syndrome and Adverse Postoperative Outcomes: A Historical Cohort Study Using Administrative Health Data.
abstract: BACKGROUND
  Sjögren syndrome is a chronic autoimmune disorder of the exocrine glands associated with cardiovascular events. We aimed to evaluate postoperative complications in patients with Sjögren syndrome undergoing noncardiac surgery. Specifically, we tested the primary hypothesis that patients with Sjögren syndrome have a greater risk of postoperative cardiovascular complications than those without the disease. Our secondary hypotheses were that patients with Sjögren syndrome are at greater risk of thromboembolic complications, microcirculatory complications, and mortality.
  
  
  METHODS
  We obtained censuses of 2009 to 2010 inpatient hospital discharges across 7 states. Sjögren syndrome was identified by the present-on-admission diagnosis code 710.2. Each Sjögren n syndrome discharge was propensity matched to 4 control discharges. A generalized linear model was used to compare matched Sjögren syndrome patients and controls on risk of in-hospital cardiovascular complications, thromboembolic complications, microcirculatory complications, and mortality.
  
  
  RESULTS
  Among 5.5 million qualifying discharges, our final matched sample contained 22,785 matched discharges, including 4557 with Sjögren syndrome. Sixty-six (1.45%) of the matched discharges with Sjögren syndrome and 213 (1.17%) of the matched controls had associated in-hospital cardiovascular complications. The adjusted odds ratio (99% confidence interval) was estimated at 1.14 (0.79-1.64), which was not statistically significant (P = 0.35). There were no significant differences in the odds of in-hospital thromboembolic complications (1.12 [0.82-1.53]; P = 0.36), in the odds of in-hospital microcirculatory complications (0.98 [0.77-1.26]; P = 0.86), or in the odds of in-hospital mortality (1.11 [0.76-1.61]; P = 0.49).
  
  
  CONCLUSIONS
  The presence of Sjögren syndrome does not place patients at an increased risk for postoperative complications or in-hospital mortality.
authors: From the *Department of Outcomes Research, †Anesthesiology Institute, and ‡Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
authors: Rovnat
authors: R
authors: Babazade
authors: Zhuo
authors: Z
authors: Sun
authors: Brian D
authors: BD
authors: Hesler
authors: Arjun
authors: A
authors: Sharma
authors: Natalya
authors: N
authors: Makarova
authors: Jarrod E
authors: JE
authors: Dalton
authors: Alparslan
authors: A
authors: Turan
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D016208:Databases, Factual / Q000706:statistics & numerical data* / Q000639:trends; D005260:Female; D006739:Hospital Administration / Q000639:trends; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge / Q000639:trends; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012859:Sjogren's Syndrome / Q000453:epidemiology* / Q000601:surgery*; D016896:Treatment Outcome