title: Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection.
abstract: Alzheimer's disease is a progressive neurodegenerative disease that typically manifests clinically as an isolated amnestic deficit that progresses to a characteristic dementia syndrome. Advances in neuroimaging research have enabled mapping of diverse molecular, functional, and structural aspects of Alzheimer's disease pathology in ever increasing temporal and regional detail. Accumulating evidence suggests that distinct types of imaging abnormalities related to Alzheimer's disease follow a consistent trajectory during pathogenesis of the disease, and that the first changes can be detected years before the disease manifests clinically. These findings have fuelled clinical interest in the use of specific imaging markers for Alzheimer's disease to predict future development of dementia in patients who are at risk. The potential clinical usefulness of single or multimodal imaging markers is being investigated in selected patient samples from clinical expert centres, but additional research is needed before these promising imaging markers can be successfully translated from research into clinical practice in routine care.
authors: Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany. Electronic address: stefan.teipel@med.uni-rostock.de.
authors: Stefan
authors: S
authors: Teipel
authors: Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
authors: Alexander
authors: A
authors: Drzezga
authors: Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany.
authors: Michel J
authors: MJ
authors: Grothe
authors: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors: Henryk
authors: H
authors: Barthel
authors: Inserm-EPHE-Université de Caen, Caen cedex, France.
authors: Gaël
authors: G
authors: Chételat
authors: Department of Veterans Affairs Medical Center and Department of Radiology, University of California in San Francisco, San Francisco, CA, USA.
authors: Norbert
authors: N
authors: Schuff
authors: Olin Neuropsychiatry Research Center, Hartford Hospital and Institute of Living, Hartford, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
authors: Pawel
authors: P
authors: Skudlarski
authors: LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine-IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy; Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Epinière, UMR S 1127, Hôpital de la Pitié-Salpêtrière Paris and CATI Multicenter Neuroimaging Platform, France.
authors: Enrica
authors: E
authors: Cavedo
authors: LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine-IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy; Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
authors: Giovanni B
authors: GB
authors: Frisoni
authors: Institute for Community Medicine, University of Greifswald, Greifswald, Germany; DZNE, German Centre for Neurodegenerative Diseases, Greifswald, Germany.
authors: Wolfgang
authors: W
authors: Hoffmann
authors: Institute for Community Medicine, University of Greifswald, Greifswald, Germany; DZNE, German Centre for Neurodegenerative Diseases, Greifswald, Germany.
authors: Jochen René
authors: JR
authors: Thyrian
authors: Dementia Research Innovation Group, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
authors: Chris
authors: C
authors: Fox
authors: Neuroimaging and Biotechnology Laboratory, Department of Radiology, University of Utah, Salt Lake City, UT, USA.
authors: Satoshi
authors: S
authors: Minoshima
authors: Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors: Osama
authors: O
authors: Sabri
authors: Department of Psychiatry, University Medical Center of Mainz, Mainz, Germany.
authors: Andreas
authors: A
authors: Fellgiebel
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D015415:Biomarkers; D042241:Early Diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000592:standards*; D064847:Multimodal Imaging / Q000592:standards*; D049268:Positron-Emission Tomography / Q000592:standards*
chemical_list: D015415:Biomarkers