title: Salivary SIgA responses to acute moderate-vigorous exercise in monophasic oral contraceptive users.
abstract: The purpose of this study was to examine the effect of oral contraceptive (OC) use on salivary secretory immunoglobulin A (SIgA) levels at rest and in response to an acute bout of moderate-vigorous exercise during 2 phases of the 4-week OC cycle corresponding to different phases of the synthetic menstrual cycle. Ten healthy active females completed a cycling at 70% peak oxygen uptake for 45 min at 2 time points of an OC cycle: during the equivalent in time to the mid-follicular phase (day 8 ± 2) and the mid-luteal phase (day 20 ± 2). Timed unstimulated saliva samples were obtained before, immediately postexercise, and 1 h postexercise and analyzed for salivary SIgA. Salivary SIgA secretion rate was 26% (95% confidence limits (CI) 6-46) lower at postexercise compared with pre-exercise during the synthetic follicular phase (p = 0.019) but no differences were observed during the synthetic luteal trial. Saliva flow rate was 11% (95% CI, 8-30) lower at postexercise compared with pre-exercise (main effect for time; p = 0.025). In conclusion, the pattern of salivary SIgA secretion rate response to moderate-vigorous exercise varies across the early and late phases of a monophasic OC cycle, with a transient reduction in salivary SIgA responses during the synthetic follicular phase. These findings indicate that monophasic OC use should be considered when assessing mucosal immune responses to acute exercise.
authors: School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.|School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
authors: Harumi
authors: H
authors: Hayashida
authors: School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.|School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
authors: Nicola J
authors: NJ
authors: Dolan
authors: School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.|School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
authors: Charlotte
authors: C
authors: Hounsome
authors: School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.|School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
authors: Nawal
authors: N
authors: Alajmi
authors: School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.|School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
authors: Nicolette C
authors: NC
authors: Bishop
mesh_terms: D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use*; D004958:Estradiol / Q000378:metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D008597:Menstrual Cycle / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D012463:Saliva / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D012469:Salivary Glands / Q000276:immunology / Q000378:metabolism*; D013997:Time Factors; D055815:Young Adult
chemical_list: D003278:Contraceptives, Oral, Hormonal; D007071:Immunoglobulin A, Secretory; D011374:Progesterone; D004958:Estradiol
keywords: aerobic exercise; contraceptifs oraux combinés monophasiques; cycle de contraception orale; estrogen; exercice aérobie; monophasic combined oral contraceptives; oral contraceptive cycle; symptômes des voies respiratoires supérieures; upper respiratory symptoms; œstrogènes