title: Distraction Osteogenesis Using Bone Matrix Osteotensors in Ectodermal Dysplasia: A Case Report.
abstract: BACKGROUND
  Ectodermal dysplasia patients require complex oral rehabilitation. Bone matrix Osteotensors activate the patient's own stem cells to promote new bone formation through an autogenous growth factor cascade generated by a targeted flapless bone distraction before implant and/or bone graft therapy.
  
  
  METHODS
  The maxillary and mandibular bone were activated 21 (for type I bone) to 45 days (for type IV bone) before implant and/or bone substitute installation. Purpose-designed Osteotensors initiated massive recruitment of stem cells in the intended bone recipient site, thereby triggering neoangiogenesis and osteogenesis. After new bone formation, root-form implants and Diskimplants were installed. Functional loading was obtained at 48 hours using highly rigid, screw-secured fixed upper and lower full-arch prostheses.
  
  
  RESULTS
  At 3 years, all implants appeared clinically and radiologically osseointegrated with an excellent functional and esthetic outcome.
  
  
  CONCLUSIONS
  Flapless distraction osteogenesis using bone matrix Osteotensors several weeks before surgery improved the initial quality and volume of the recipient bone bed. This minimally invasive approach allows future successful immediate implant-supported complete maxillomandibular fixed rehabilitation without preliminary grafting procedures in patients with an unfavorable initial bone anatomy.
authors: *Chairman, Department of Maxillo-Facial Surgery, Institut Universitaire de la Face et du Cou and School of Medicine, University of Nice Sophia Antipolis, Nice, France. †Private Practice, Antibes, France. ‡Private Practice, Barcelona, Spain. §Department of Histology, School of Medicine, University of Nice Sophia Antipolis, Nice, France.
authors: Guillaume
authors: G
authors: Odin
authors: Renaud
authors: R
authors: Petitbois
authors: Philippe
authors: P
authors: Cotten
authors: Patrick
authors: P
authors: Philip
mesh_terms: D000328:Adult; D000848:Anodontia / Q000601:surgery*; D001857:Bone Matrix / Q000378:metabolism*; D016025:Bone Transplantation / Q000379:methods; D003758:Dental Implantation, Endosseous / Q000379:methods*; D019094:Dental Prosthesis, Implant-Supported / Q000379:methods; D004476:Ectodermal Dysplasia / Q000150:complications*; D006801:Humans; D008297:Male; D019857:Osteogenesis, Distraction / Q000379:methods*