title: Organocatalytic dynamic kinetic resolution of azlactones to construct chiral N-acyl amino acid oxime esters.
abstract: A direct strategy to obtain N-acyl amino acid oxime esters has been developed through the dynamic kinetic resolution of azlactones with oximes. In the presence of a chiral bisguanidinium salt catalyst, a variety of chiral N-acyl amino acid oxime esters were generated in excellent enantiomeric excesses (up to 97%) and high yields (up to 99%). The active oxime esters could be used in dipeptide synthesis.
authors: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. liuxh@scu.edu.cn.
authors: Kunru
authors: K
authors: Yu
authors: Xiaohua
authors: X
authors: Liu
authors: Xiaobin
authors: X
authors: Lin
authors: Lili
authors: L
authors: Lin
authors: Xiaoming
authors: X
authors: Feng
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D007700:Kinetics; D007783:Lactones / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D004952:Esters; D007783:Lactones; D010091:Oximes