title: CXCL10 in psoriasis.
abstract: Chemokine (C-X-C motif) ligand (CXCL)10 is involved in the pathogenesis of psoriasis. It has been demonstrated that chemokine (C-X-C motif) receptors (CXCR)3 and CXCL10 were detected in keratinocytes and the dermal infiltrate obtained from active psoriatic plaques and that successful treatment of active plaques decreased the expression of CXCL10. Elevated CXCL10 serum levels have been shown in patients with psoriasis, with a type 1 T helper cells immune predominance at the beginning of the disease, while a decline of this chemokine has been evidenced later, in long lasting psoriasis. Circulating CXCL10 is significantly higher in patients with psoriasis in the presence of autoimmune thyroiditis. It has been hypothesized that CXCL10 could be a good marker to monitor the activity or progression of psoriasis. Efforts have been made to modulate or inhibit the CXCR3/CXCL10 axis in psoriasis to modify the course of the disease.
authors: Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors: Silvia Martina
authors: SM
authors: Ferrari
authors: Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors: Ilaria
authors: I
authors: Ruffilli
authors: Rheumatology Unit, Medical School, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.
authors: Michele
authors: M
authors: Colaci
authors: Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address: alessandro.antonelli@med.unipi.it.
authors: Alessandro
authors: A
authors: Antonelli
authors: Rheumatology Unit, Medical School, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.
authors: Clodoveo
authors: C
authors: Ferri
authors: Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors: Poupak
authors: P
authors: Fallahi
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000502:physiology; D054357:Chemokine CXCL10 / Q000378:metabolism*; D006801:Humans; D011565:Psoriasis / Q000378:metabolism*; D054367:Receptors, CXCR3 / Q000378:metabolism
chemical_list: D054357:Chemokine CXCL10; D054367:Receptors, CXCR3
keywords: Autoimmunity; CXCL10; CXCR3; Psoriasis