title: Association of CELF2 polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population.
abstract: Nasopharyngeal carcinoma (NPC) is a malignancy with high metastatic potential and loco-regional recurrence. The overall survival of NPC has been limited from further improvement partly due to the lack of effective biomarker for accurate prognosis prediction and precise treatments. Here, in light of the implication of CELF gene family in cancer prognosis, we selected 112 tagging single nucleotide polymorphisms (SNPs) located in six members of the family and tested their associations with the clinical outcomes in a discovery cohort of 717 NPC patients. Survival analyses under multivariate cox proportional hazards model and Kaplan-Meier curve revealed five promising SNPs, which were further validated in another independent sample of 1,520 cases. Combined analysis revealed that SNP rs3740194 in CELF2 was significantly associated with the decreased risk of death with a Hazard ratio (HR) of 0.69 (95% confidence interval [CI] = 0.58-0.82, codominant model). Moreover, rs3740194 also showed a significant association with superior metastasis-free survival (HR = 0.69, 95% CI = 0.57-0.83, codominant model). Taken together, our findings suggested that genetic variant of rs3740194 in CELF2 gene might be a valuable predictor for NPC prognosis, and potentially useful in the personalized treatment of NPC.
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.
authors: Yun-Miao
authors: YM
authors: Guo
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.
authors: Ming-Xia
authors: MX
authors: Sun
authors: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.
authors: Jing
authors: J
authors: Li
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.
authors: Tong-Tong
authors: TT
authors: Liu
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.
authors: Hang-Zhen
authors: HZ
authors: Huang
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.
authors: Jie-Rong
authors: JR
authors: Chen
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.
authors: Wen-Sheng
authors: WS
authors: Liu
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.
authors: Qi-Sheng
authors: QS
authors: Feng
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.
authors: Li-Zhen
authors: LZ
authors: Chen
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.
authors: Jin-Xin
authors: JX
authors: Bei
authors: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China.|Peking Union Medical College, Beijing, P. R. China.
authors: Yi-Xin
authors: YX
authors: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000067878:CELF Proteins / Q000235:genetics* / Q000378:metabolism; D002277:Carcinoma; D002648:Child; D002681:China; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005787:Gene Frequency; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000378:metabolism* / Q000401:mortality; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000067878:CELF Proteins; C117363:CELF2 protein, human; D009419:Nerve Tissue Proteins
keywords: CELF2; SNP; nasopharyngeal carcinoma; prognosis