title: Over 50 Years of Fibrinogen Concentrate.
abstract: March 2013 represented the 50th anniversary of the first license granted for a fibrinogen concentrate. In this review, we look at the history of bleeding management that led to the development of fibrinogen concentrate, discuss its current use, and consider future developments for this product.
authors: Department of Critical Care, Hospital Pró-Cardíaco, Rio de Janeiro, Brazil rubens1956@gmail.com.
authors: Rubens
authors: R
authors: Costa-Filho
authors: CSL Behring, Vienna, Austria.
authors: Gerald
authors: G
authors: Hochleitner
authors: CSL Behring, Marburg, Germany.
authors: Michael
authors: M
authors: Wendt
authors: Hospital Israelita Albert Einstein and Hospital Moriah, São Paulo, Brazil.
authors: Alexandre
authors: A
authors: Teruya
authors: Institute of Anaesthesiology, University and University Hospital of Zurich, Switzerland.
authors: Donat R
authors: DR
authors: Spahn
mesh_terms: D000846:Anniversaries and Special Events; D005340:Fibrinogen / Q000266:history / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy* / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans
chemical_list: D005340:Fibrinogen
keywords: bleeding; blood coagulation factors; hemostasis