title: Therapeutic Effects of Melatonin On Liver And Kidney Damages In Intensive Exercise Model of Rats.
abstract: Extensive exercise induces inflammatory reactions together with high production of free radicals and subsequent liver and kidney tissues damage. This study was designed to investigate for effects of melatonin on liver and kidney tissues in the extensive exercise exposed rats and non-exercised rats. In this research, 24-male Sprague-Dawley rats were divided into four groups. For exercise rat model, the rats were exposed to slow pace running with the velocity of 10 m/min for 5 minutes for five days just before the study. And for last ten days after adaptation period, the exercise was improved as 15 min with the speed of 20 m/min and intra-peritoneal melatonin injection has been performed to the melatonin treated groups with the dose of 10 mg/kg. Biochemical results revealed a decrease in the parameters of kidney and liver enzymes in exercise-group and an increase in the parameters of serum, liver and kidney enzymes in the group that melatonin-exercise-group. As for histological analysis, while it is observed that there are cellular degenerations in the liver and kidney tissues with exercise application, a decrease has been observed in these degenerations in the group that melatonin was applied. At the end of the research, it has been determined that exercise application causes some damages on liver and kidney, and these damages were ameliorated with melatonin treatment.
authors: Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Atatürk, 25240, Erzurum, Turkey. semingedikli@gmail.com.
authors: Semin
authors: S
authors: Gedikli
authors: Volkan
authors: V
authors: Gelen
authors: Emin
authors: E
authors: Sengul
authors: Seckin
authors: S
authors: Ozkanlar
authors: Cihan
authors: C
authors: Gur
authors: Ozturk
authors: O
authors: Agırbas
authors: Fatih
authors: F
authors: Cakmak
authors: Adem
authors: A
authors: Kara
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D048550:Hepatic Insufficiency / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009043:Motor Activity; D018384:Oxidative Stress / Q000187:drug effects*; D005082:Physical Exertion; D017207:Rats, Sprague-Dawley; D051437:Renal Insufficiency / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000187:drug effects*; D014508:Urea / Q000097:blood
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D015415:Biomarkers; D014508:Urea; D003404:Creatinine; D008550:Melatonin