title: [Expression of BAG3 Gene in Acute Myeloid Leukemia and Its Prognostic Value].
abstract: OBJECTIVE
  To investigate the expression of BAG3 gene in acue myeloid leukemia (AML) and its prognostic value.
  
  
  METHODS
  Real-time quantitative RT-PCR was used to detect the expression of BAG3 mRNA in 88 previously untreated AML patients. The corelation of BAG3 expression level with clinical characteristics and known prognostic markers of AML was analyzed.
  
  
  RESULTS
  In 88 patients with AML, the expression of BAG3 mRNA in NPMI mutated AML patients was obviously lower than that in NPMI unmutated patients (P = 0.018). The expression level of BAG3 mRNA did not related to clinical parameters, such as age, sex, FAB subtype, WBC count, extra-modullary presentation, and to prognostic factors including cytogenetics, FLT3-ITD, c-kit and CEBPα mutation status (P > 0.05). The expression level of BAG3 had no obvious effect on complete remission (CR) of patients in first treatment. The expression level of BAG3 in non-M3 patients was higher than that in relapsed patients (P = 0.036). The expression level of BAG3 had no effect on overall survival (OS) of patients.
  
  
  CONCLUSIONS
  The expression level of BAG3 does not correlated with known-prognostic markers of AML, only the expression level of BAG3 in NPM1 mutated patients is lower than that in NPM1 unmutated patients. The expression level of BAG3 has no effect on OS of AML patients, the BAG3 can not be difined as a prognostic marker in AML.
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University; Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Hua-Yuan
authors: HY
authors: Zhu
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University; Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Yuan
authors: Y
authors: Fu
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University; Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Wei
authors: W
authors: Wu
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University; Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Jia-Dai
authors: JD
authors: Xu
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University; Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Ting-Mei
authors: TM
authors: Chen
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University; Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Chun
authors: C
authors: Qiao
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University; Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China. E-mail: lijianyonglm@medmail.com.cn.
authors: Jian-Yong
authors: JY
authors: Li
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University; Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China. E-mail: liupeng9098@163.com.
authors: Peng
authors: P
authors: Liu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D003582:Cytogenetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D007958:Leukocyte Count; D009154:Mutation; D000090243:Nucleophosmin; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit; D012333:RNA, Messenger; D060888:Real-Time Polymerase Chain Reaction; D012074:Remission Induction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C414431:BAG3 protein, human; C000716967:NPM1 protein, human; D012333:RNA, Messenger; D000090243:Nucleophosmin; D019009:Proto-Oncogene Proteins c-kit