title: Performance Evaluation of the Sysmex CS-5100 Automated Coagulation Analyzer.
abstract: BACKGROUND
  Coagulation testing is widely applied clinically, and laboratories increasingly demand automated coagulation analyzers with short turn-around times and high-throughput. The purpose of this study was to evaluate the performance of the Sysmex CS-5100 automated coagulation analyzer for routine use in a clinical laboratory.
  
  
  METHODS
  The prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (Fbg), and D-dimer were compared between the Sysmex CS-5100 and Sysmex CA-7000 analyzers, and the imprecision, comparison, throughput, STAT function, and performance for abnormal samples were measured in each.
  
  
  RESULTS
  The within-run and between-run coefficients of variation (CV) for the PT, APTT, INR, and D-dimer analyses showed excellent results both in the normal and pathologic ranges. The correlation coefficients between the Sysmex CS-5100 and Sysmex CA-7000 were highly correlated. The throughput of the Sysmex CS-5100 was faster than that of the Sysmex CA-7000. There was no interference at all by total bilirubin concentrations and triglyceride concentrations in the Sysmex CS-5100 analyzer.
  
  
  CONCLUSIONS
  We demonstrated that the Sysmex CS-5100 performs with satisfactory imprecision and is well suited for coagulation analysis in laboratories processing large sample numbers and icteric and lipemic samples.
authors: Liming
authors: L
authors: Chen
authors: Yu
authors: Y
authors: Chen
mesh_terms: D057205:Automation, Laboratory; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D001780:Blood Coagulation Tests / Q000295:instrumentation*; D004867:Equipment Design; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D019934:International Normalized Ratio / Q000295:instrumentation; D008422:Materials Testing; D010314:Partial Thromboplastin Time / Q000295:instrumentation; D011237:Predictive Value of Tests; D011517:Prothrombin Time / Q000295:instrumentation; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D