title: Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma.
abstract: Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.
authors: School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, United States; NIEHS Center for Children's Environmental Health, University of California, Davis, United States. Electronic address: mdeloi@ucdavis.edu.
authors: Marjannie Eloi
authors: ME
authors: Akintunde
authors: NIEHS Center for Children's Environmental Health, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States; School of Public Health Sciences, University of California, Davis, United States.
authors: Melissa
authors: M
authors: Rose
authors: The M.I.N.D. Institute, University of California, Davis, United States; School of Public Health Sciences, University of California, Davis, United States.
authors: Paula
authors: P
authors: Krakowiak
authors: School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States.
authors: Luke
authors: L
authors: Heuer
authors: NIEHS Center for Children's Environmental Health, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States; School of Medicine, Department of Microbiology and Immunology, United States.
authors: Paul
authors: P
authors: Ashwood
authors: NIEHS Center for Children's Environmental Health, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States; Department of Pediatrics, School of Medicine, University of California, Davis, United States.
authors: Robin
authors: R
authors: Hansen
authors: NIEHS Center for Children's Environmental Health, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States; School of Public Health Sciences, University of California, Davis, United States.
authors: Irva
authors: I
authors: Hertz-Picciotto
authors: School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, United States; NIEHS Center for Children's Environmental Health, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States.
authors: Judy
authors: J
authors: Van de Water
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000473:pathology*; D016022:Case-Control Studies; D002659:Child Development Disorders, Pervasive / Q000453:epidemiology / Q000473:pathology*; D002675:Child, Preschool; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D015851:Interleukin-7 / Q000378:metabolism*; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D018709:Statistics, Nonparametric; D058504:Th17 Cells / Q000187:drug effects / Q000378:metabolism*; D018418:Th2 Cells / Q000187:drug effects / Q000378:metabolism*
chemical_list: D016207:Cytokines; C508605:IL7 protein, human; D015851:Interleukin-7; D008934:Mitogens; D010835:Phytohemagglutinins
keywords: Asthma; Autism; Food allergies; IL-17