title: Thoracic primary central nervous system melanoma and lumbar schwannoma of complex neurocristopathy: case report.
abstract: Complex neurocristopathy, a disorder resulting from the aberrant proliferation of tissues derived from neural crest cells, has been previously reported in 2 patients, both involving ophthalmic melanoma and other tumors. One patient had a periorbital neurofibroma, sphenoid wing meningioma, and choroid juxtapapillary meningioma. The other patient had a choroidal melanoma and an optic nerve sheath meningioma. The authors describe clinical and pathological findings in a patient who underwent resection of 2 distinct lesions: primary CNS melanoma at T-12 and an L-5 schwannoma. Clinical and histopathological findings of the case are reviewed. To the authors' knowledge, this is the first patient to present with complex neurocristopathy involving both a spinal melanoma and schwannoma.
authors: University of Texas Medical School, Houston, Texas; and |Departments of 2 Neurological Surgery and.
authors: Aaron
authors: A
authors: Chance
authors: Departments of 2 Neurological Surgery and.
authors: Jesse J
authors: JJ
authors: Liu
authors: Departments of 2 Neurological Surgery and.
authors: Jeffrey S
authors: JS
authors: Raskin
authors: Pathology, Oregon Health & Science University, Portland, Oregon.
authors: Viktor
authors: V
authors: Zherebitskiy
authors: Pathology, Oregon Health & Science University, Portland, Oregon.
authors: Sakir H
authors: SH
authors: Gultekin
authors: Departments of 2 Neurological Surgery and.
authors: Ahmed M
authors: AM
authors: Raslan
mesh_terms: D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000628:therapy; D009442:Neurilemmoma / Q000175:diagnosis* / Q000628:therapy; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000628:therapy; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D013904:Thoracic Vertebrae
keywords: complex neurocristopathy; melanocytoma; oncology; schwannoma; spinal melanoma