title: Colorectal adenoma is associated with coronary artery calcification in a Korean population.
abstract: OBJECTIVE
  Colorectal adenoma and coronary atherosclerosis have similar risk factors. The aim of this study was to investigate the association between colorectal adenoma and coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis.
  
  
  METHODS
  This is a cross-sectional study of 398 Koreans (290 males, mean age of 56.8 ± 8.1 years) who underwent CAC scoring by multi-slice computed tomography and colonoscopy on the same day as the screening examination. The CAC scores were divided into the following three categories according to severity: absent (CAC score = 0), mild (0 < CAC score ≤ 100), and moderate-to-severe CAC (CAC score > 100).
  
  
  RESULTS
  Colorectal adenoma was detected in 149 (37.4%) subjects and was significantly associated with a CAC score of >0 (OR = 1.66, 95% CI = 1.05-2.64, P = 0.032), including both mild (OR = 1.80, 95% CI = 1.06-3.03, P = 0.029) and moderate-to-severe CAC (OR = 1.95, 95% CI = 1.05-3.63, P = 0.035), in multivariate analysis after adjusting for age, gender and other risk factors. The proportion of subjects with colorectal adenoma and advanced adenoma progressively increased with increasing CAC score (colorectal adenoma 28.9%-54.1%, P for trend < 0.001; advanced adenoma 7.0%-16.4%, P for trend = 0.026).
  
  
  CONCLUSIONS
  Colorectal adenoma is related to coronary artery calcification independent of traditional risk factors for asymptomatic Koreans. The prevalence of advanced adenoma is more common in individuals with severe coronary atherosclerosis.
authors: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.
authors: Seung Ho
authors: SH
authors: Choi
authors: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea. Electronic address: joybell77@hanmail.net.
authors: Hae Yeon
authors: HY
authors: Kang
authors: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.
authors: Su Yeon
authors: SY
authors: Choi
authors: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.
authors: Mi Na
authors: MN
authors: Kim
authors: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.
authors: Jong In
authors: JI
authors: Yang
authors: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.
authors: Su Jin
authors: SJ
authors: Chung
authors: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.
authors: Sun Young
authors: SY
authors: Yang
authors: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.
authors: Young Sun
authors: YS
authors: Kim
authors: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea; Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
authors: Joo Sung
authors: JS
authors: Kim
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology; D000368:Aged; D002114:Calcinosis / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology; D003324:Coronary Artery Disease / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology; D003331:Coronary Vessels / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D015995:Prevalence; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Colorectal adenoma; Coronary artery calcification; Screening