title: Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions.
abstract: Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided procedure for hydrodynamics-based gene delivery in large animals directly supports the clinical applicability of this technique. This review summarizes the current status and recent progress in the development of hydrodynamics-based gene delivery and discusses the future directions for its clinical application.
authors: Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. kenya-k@med.niigata-u.ac.jp.
authors: Kenya
authors: K
authors: Kamimura
authors: Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. t-yokoo@med.niigata-u.ac.jp.
authors: Takeshi
authors: T
authors: Yokoo
authors: Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. hiroyukiabe@med.niigata-u.ac.jp.
authors: Hiroyuki
authors: H
authors: Abe
authors: Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. yuji@med.niigata-u.ac.jp.
authors: Yuji
authors: Y
authors: Kobayashi
authors: Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. kogawa@med.niigata-u.ac.jp.
authors: Kohei
authors: K
authors: Ogawa
authors: Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. yoko-s@med.niigata-u.ac.jp.
authors: Yoko
authors: Y
authors: Shinagawa
authors: Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. r-inoue@med.niigata-u.ac.jp.
authors: Ryosuke
authors: R
authors: Inoue
authors: Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. terais@med.niigata-u.ac.jp.
authors: Shuji
authors: S
authors: Terai
keywords: DNA; clinical application; gene therapy; hydrodynamics-based gene delivery