title: A novel route for the removal of bodily heavy metal lead (II).
abstract: The lead ion concentration in bile is considerably higher than in blood, and bile is released into the alimentary tract. Thiol-modified SBA-15 administered orally can combine with lead ions in the alimentary tract. In this paper, the in vitro lead absorption of bile was investigated. This thiol-modified SBA-15 material was used in pharmacodynamics studies on rabbits. The result that the lead content in faeces was notably higher indicates that thiol-modified SBA-15 can efficiently remove lead. The mechanism could include the following: thiol-modified SBA-15 material cuts off the heavy metal lead recirculation in the process of bile enterohepatic circulation by chelating the lead in the alimentary tract, causing a certain proportion of lead to be removed by the thiol mesoporous material, and the lead is subsequently egested out of the body in faeces. The results indicate that this material might be a potential non-injection material for the removal bodily heavy metal lead in the alimentary tract. This material may also be a useful means of lead removal, especially for non-acute sub-poisoning symptoms.
authors: Laboratory of Nano-Biology Technology, Central South University, Changsha, 410083, People's Republic of China. School of Physics and Electronics Changsha University of Science and Technology, Changsha, 410004, People's Republic of China.
authors: Weirong
authors: W
authors: Huang
authors: Penghua
authors: P
authors: Zhang
authors: Hui
authors: H
authors: Xu
authors: Shengli
authors: S
authors: Chang
authors: Yongju
authors: Y
authors: He
authors: Fei
authors: F
authors: Wang
authors: Gaowei
authors: G
authors: Liang
mesh_terms: D000327:Adsorption; D000818:Animals; D001646:Bile / Q000378:metabolism*; D005243:Feces; D007854:Lead / Q000097:blood / Q000302:isolation & purification* / Q000378:metabolism / Q000493:pharmacokinetics; D007855:Lead Poisoning / Q000188:drug therapy; D017348:Microscopy, Electron, Scanning Transmission; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D011817:Rabbits; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D013438:Sulfhydryl Compounds; D007854:Lead