title: Tumor necrosis factor-α induced protein 6 attenuates acute lung injury following paraquat exposure.
abstract: BACKGROUND
  Paraquat exposure commonly occurs in the developing countries and the mortality rate is high. However, there is currently no consensus on the efficacy of treatment for paraquat exposure.
  
  
  OBJECTIVE
  The study was aimed to explore the effects of tumor necrosis factor-α (TNF-α) induced protein 6 (TSG-6) on acute lung injury (ALI) following paraquat exposure in rats.
  
  
  METHODS
  Male Sprague-Dawley (SD) rats were randomly divided into the sham group (n = 8), the paraquat group (n = 8), and the paraquat TSG-6-treated group (n = 8). Rats were administered with 50 mg/kg of paraquat intraperitoneally. At 1 h after exposure, rats were treated with 30 μg of recombinant human TSG-6 (rhTSG-6) intraperitoneally. After 6 h of exposure, ALI scores were evaluated by histology and the expression of pro-inflammatory cytokines in lung was assayed using real-time RT-PCR.
  
  
  RESULTS
  ALI scores were significantly lower in the paraquat TSG-6-treated group, compared with the paraquat group (p < 0.05). The expression of interleukin (IL)-1β, IL-6, and TNF-α mRNA was significantly lower in the paraquat TSG-6-treated group, compared with the paraquat group (p < 0.01, respectively).
  
  
  CONCLUSIONS
  Administration of rhTSG-6 attenuates ALI following paraquat exposure by suppressing inflammatory response.
authors: a Department of Emergency , Quanzhou First Hospital Affiliated Fujian Medical University , Quanzhou , China and.
authors: Jiajun
authors: J
authors: Xu
authors: a Department of Emergency , Quanzhou First Hospital Affiliated Fujian Medical University , Quanzhou , China and.
authors: Jiantao
authors: J
authors: Zhen
authors: a Department of Emergency , Quanzhou First Hospital Affiliated Fujian Medical University , Quanzhou , China and.
authors: Jingfa
authors: J
authors: Zhu
authors: b Department of Emergency , Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University , Fuzhou , China.
authors: Qingming
authors: Q
authors: Lin
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced* / Q000188:drug therapy; D000818:Animals; D015815:Cell Adhesion Molecules / Q000008:administration & dosage / Q000494:pharmacology*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D008168:Lung / Q000378:metabolism; D008297:Male; D010269:Paraquat / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D015815:Cell Adhesion Molecules; D016207:Cytokines; D011994:Recombinant Proteins; C072273:TNFAIP6 protein, human; D010269:Paraquat
keywords: Inflammation; lung injury; paraquat; tumor necrosis factor-α induced protein 6