title: Foreign body reactions may not influence the keloid recurrence.
abstract: OBJECTIVE
  The foreign body reactions are comprised of macrophages and foreign body giant cells and are considered possible risk factors for recurrence in several conditions. The purpose of this study was to determine the effect of pathologically proven foreign body reactions on the recurrence of the auricular keloids.
  
  
  METHODS
  This study was carried out in 76 cases in 70 patients reaching the pathologic diagnosis of auricular keloids from March 2006 to February 2012. Patients with auricular keloids were included in the study according to the following criteria: The keloid scar was caused by ear piercing and confirmed pathologically; surgical excision with primary closure was performed; and female patients who have not underwent any previous treatments. To compare any differences of recurrence rate between categorical variables (the presence/absence of foreign body reactions), Fisher's exact tests were used. All patients completed the treatment protocol with a follow-up interval of 18 months.
  
  
  RESULTS
  Of these patients, 90.9% (69 keloids) had successful irradication of their auricular keloids, whereas 9.2% (seven keloids) had recurrences. Of the seven recurrent cases, two exhibited foreign body reactions at pathology, while five revealed no foreign body reactions (28.6% vs. 71.4%, P = 0.092).
  
  
  CONCLUSIONS
  Detection of foreign body reactions in keloid tissue may not predict recurrence in auricular keloids.
authors: Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, South Korea.|Keloid Research Foundation, New York, NY, USA.|Buleun Health Care Center, Incheon, South Korea.
authors: Tae Hwan
authors: TH
authors: Park
authors: Department of Pathology, Samsung Medical Center, Seoul, South Korea.
authors: Boram
authors: B
authors: Lee
authors: Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
authors: Ji Hae
authors: JH
authors: Park
authors: Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, South Korea.
authors: Dong Kyun
authors: DK
authors: Rah
mesh_terms: D046288:Body Piercing / Q000009:adverse effects; D054644:Ear Auricle; D004427:Ear Diseases / Q000209:etiology*; D005260:Female; D005549:Foreign-Body Reaction / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007627:Keloid / Q000209:etiology* / Q000473:pathology*; D012008:Recurrence
keywords: foreign body; keloid; macrophage; recurrence