title: Chromatin states and nuclear organization in development--a view from the nuclear lamina.
abstract: The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.
authors: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland. anna.mattout@fmi.ch.
authors: Anna
authors: A
authors: Mattout
authors: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland. daphne.cabianca@fmi.ch.
authors: Daphne S
authors: DS
authors: Cabianca
authors: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland. susan.gasser@fmi.ch.|University of Basel, Faculty of Natural Sciences, Klingelbergstrasse 50, CH-4056, Basel, Switzerland. susan.gasser@fmi.ch.
authors: Susan M
authors: SM
authors: Gasser
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism*; D044127:Epigenesis, Genetic; D016678:Genome; D006570:Heterochromatin / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D034882:Lamins / Q000235:genetics; D051379:Mice; D034881:Nuclear Lamina / Q000235:genetics*
chemical_list: D002843:Chromatin; D006570:Heterochromatin; D006657:Histones; D034882:Lamins