title: Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis.
abstract: Accumulating evidence suggests that interferon (IFN) alpha/beta are involved in antitumor immunity and cancer immunoediting, but information on the antitumor effects of IFN alpha/beta in lung cancer is limited. In our study, we elucidated the IFN alpha/beta signature during both human fetal lung development and lung tumorigenesis. Our findings indicated gradual upregulation in the IFN alpha/beta signature during human fetal lung development. In addition, this signature was progressively downregulated in normal human airway epithelial cells from lung cancer patients, in immortalized human bronchial epithelial cell lines from later passages, in late-stage lung squamous cell carcinoma (LSCC) tissues, and in LSCC tissues exhibiting lymph node metastasis. Therefore, from its earliest stages, lung tumorigenesis may be associated with a decreased IFN alpha/beta signature. This association may provide insight to guide the detection of high-risk lung cancer patients.
authors: 1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
authors: Run
authors: R
authors: Tong
authors: 1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
authors: Lin
authors: L
authors: Feng
authors: 2 Department of Endoscopy, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
authors: Lei
authors: L
authors: Zhang
authors: 3 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery, Peking University School of Oncology , Beijing Cancer Hospital & Institute, Beijing, P.R. China .
authors: Jianzhi
authors: J
authors: Zhang
authors: 4 Department of Thoracic Surgery, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
authors: Yousheng
authors: Y
authors: Mao
authors: 1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
authors: Kaitai
authors: K
authors: Zhang
authors: 1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
authors: Yanning
authors: Y
authors: Gao
authors: 2 Department of Endoscopy, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
authors: Guiqi
authors: G
authors: Wang
authors: 1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
authors: Shujun
authors: S
authors: Cheng
mesh_terms: D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D066264:Datasets as Topic; D015536:Down-Regulation; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D016899:Interferon-beta / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D020545:Respiratory Mucosa / Q000187:drug effects / Q000378:metabolism
chemical_list: D016898:Interferon-alpha; D016899:Interferon-beta