title: Can mixed pure hepatocellular carcinoma and germinoma arise together in the brain?
abstract: Intracranial germ-cell tumors (GCTs) represent 10-15% of all pediatric brain tumors in East Asia. There is a wide histopathological spectrum of intracranial GCTs. Germinomas and nongerminomatous GCTs are the two major classifications. It is difficult to distinguish different subtypes of intracranial GCTs based solely on imaging studies, however, some tumor markers, such as α-fetoprotein or β-human chorionic gonadotropin, are helpful for diagnosis. In this study we present the case of a 13-year-old girl with an intracranial mixed GCT containing a hepatocellular carcinoma and germinoma without a primary liver tumor. Based on this unique pathological diagnosis, a series of treatments were applied, including surgery for gross tumor removal, adjuvant radiotherapy, and chemotherapy. Long-term follow up indicates fair disease control.
authors: Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Nuclear Medicine, China Medical University Hospital, Taichung, Taiwan, ROC.
authors: Lu-Jen
authors: LJ
authors: Chen
authors: Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
authors: I-Chun
authors: IC
authors: Lai
authors: Division of Pediatric Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
authors: Tai-Tong
authors: TT
authors: Wong
authors: Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
authors: Shih-Chieh
authors: SC
authors: Lin
authors: Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
authors: Donald Ming-Tak
authors: DM
authors: Ho
authors: Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
authors: Kai-Ping
authors: KP
authors: Chang
authors: Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
authors: Wan-Yuo
authors: WY
authors: Guo
authors: Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
authors: Sang-Hue
authors: SH
authors: Yen
authors: Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
authors: Ming-Teh
authors: MT
authors: Chen
authors: Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address: chenyw@vghtpe.gov.tw.
authors: Yi-Wei
authors: YW
authors: Chen
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology* / Q000601:surgery
keywords: germ-cell tumor; germinoma; hepatocellular carcinoma; pediatric brain tumor; radiotherapy