title: High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men.
abstract: BACKGROUND
  Microdeletions of the Y chromosome are one of the most frequent genetic causes of spermatogenic failure in infertile men. But their role in gaining weight is unclear. The present study investigated the possible association of these partial microdeletions and obesity.
  
  
  METHODS
  In a case-control study, 180 males were selected. The prevalence of microdeletions was assessed using PCR in AZFc area of Y chromosome and statistical analysis was done using the Fisher exact test and Pearson correlation.
  
  
  RESULTS
  In our study, inverse relationship was observed between body mass index and testosterone level (p-value: 0.005). Fisher exact tests showed that there was a significant association between gr/gr mutation and BMI (p-value: 0.044).
  
  
  CONCLUSIONS
  Our study revealed that Y chromosome microdeletions are more common in obese men. Furthermore, microdeletions such as gr/gr, which were observed in normal men, could cause decreased testosterone level. So, they may contribute to gaining weight.
authors: Department of Biology, School of Basic Sciences, Golestan University, Gorgan, Iran.
authors: Atefeh
authors: A
authors: Biabangard Zak
authors: Department of Biology, School of Basic Sciences, Golestan University, Gorgan, Iran.
authors: Masoud
authors: M
authors: Golalipour
authors: Department of Biology, School of Basic Sciences, Golestan University, Gorgan, Iran.
authors: Gholamreza
authors: G
authors: Hadadchi
keywords: Obesity; Testosterone; Y chromosome microdeletions