title: International veterinary epilepsy task force consensus proposal: outcome of therapeutic interventions in canine and feline epilepsy.
abstract: Common criteria for the diagnosis of drug resistance and the assessment of outcome are needed urgently as a prerequisite for standardized evaluation and reporting of individual therapeutic responses in canine epilepsy. Thus, we provide a proposal for the definition of drug resistance and partial therapeutic success in canine patients with epilepsy. This consensus statement also suggests a list of factors and aspects of outcome, which should be considered in addition to the impact on seizures. Moreover, these expert recommendations discuss criteria which determine the validity and informative value of a therapeutic trial in an individual patient and also suggest the application of individual outcome criteria. Agreement on common guidelines does not only render a basis for future optimization of individual patient management, but is also a presupposition for the design and implementation of clinical studies with highly standardized inclusion and exclusion criteria. Respective standardization will improve the comparability of findings from different studies and renders an improved basis for multicenter studies. Therefore, this proposal provides an in-depth discussion of the implications of outcome criteria for clinical studies. In particular ethical aspects and the different options for study design and application of individual patient-centered outcome criteria are considered.
authors: Department of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximillians-University, Königinstr. 16, 80539, Munich, Germany. potschka@pharmtox.vetmed.uni-muenchen.de.
authors: Heidrun
authors: H
authors: Potschka
authors: Service Neurology at the Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Veterinärstr. 13, 80539, Munich, Germany. andreafischer@lmu.de.
authors: Andrea
authors: A
authors: Fischer
authors: Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Bünteweg 17, 30559, Hannover, Germany. Wolfgang.Loescher@tiho-hannover.de.
authors: Wolfgang
authors: W
authors: Löscher
authors: University of Minnesota College of Veterinary Medicine, D426 Veterinary Medical Center, 1352 Boyd Avenue, St. Paul, MN, 55108, USA. patte037@umn.edu.
authors: Ned
authors: N
authors: Patterson
authors: Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium. sofie.bhatti@ugent.be.
authors: Sofie
authors: S
authors: Bhatti
authors: Department of Veterinary and Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark. mbe@sund.ku.dk.
authors: Mette
authors: M
authors: Berendt
authors: Animal Health Trust, Lanwades Park, Kentford, Newmarket, CB8 7UU, Suffolk, UK. luisa.derisio@aht.org.uk.
authors: Luisa
authors: L
authors: De Risio
authors: Fernside Veterinary Centre, 205 Shenley Road, Borehamwood, SG9 0TH, Hertfordshire, UK. robyn.fernside@googlemail.com.
authors: Robyn
authors: R
authors: Farquhar
authors: University of Melbourne, 250 Princes Highway, Weibee, 3015, VIC, Australia. snlong@unimelb.edu.au.
authors: Sam
authors: S
authors: Long
authors: Department of Clinical Sciences of Companion Animals, Utrecht University, Yalelaan 108, 3583 CM, Utrecht, The Netherlands. P.J.J.Mandigers@uu.nl.
authors: Paul
authors: P
authors: Mandigers
authors: Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Veterinärstr. 13, 80539, Munich, Germany. matiasek@patho.vetmed.uni-muenchen.de.
authors: Kaspar
authors: K
authors: Matiasek
authors: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, NC, 27607, USA. krmunana@ncsu.edu.
authors: Karen
authors: K
authors: Muñana
authors: Clinical Unit of Internal Medicine Small Animals, University of Veterinary Medicine, Veterinärplatz 1, 1210, Vienna, Austria. akos.pakozdy@vetmeduni.ac.at.
authors: Akos
authors: A
authors: Pakozdy
authors: Vet Extra Neurology, Broadleys Veterinary Hospital, Craig Leith Road, Stirling, FK7 7LE, Stirlingshire, UK. jacques.penderis@vet-neurology.co.uk.
authors: Jacques
authors: J
authors: Penderis
authors: College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA, 30602, USA. srplatt@uga.edu.
authors: Simon
authors: S
authors: Platt
authors: Chicago Veterinary Neurology and Neurosurgery, 3123 N. Clybourn Avenue, Chicago, IL, 60618, USA. mpodell@comcast.net.
authors: Michael
authors: M
authors: Podell
authors: Fitzpatrick Referrals, Halfway Lane, Eashing, Godalming, GU7 2QQ, Surrey, UK. ClareR@fitzpatrickreferrals.co.uk.|School of Veterinary Medicine, Faculty of Health & Medical Sciences, University of Surrey, Guildford, GU2 7TE, Surrey, UK. ClareR@fitzpatrickreferrals.co.uk.
authors: Clare
authors: C
authors: Rusbridge
authors: Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Bünteweg 9, 30559, Hannover, Germany. Veronika.Stein@tiho-hannover.de.
authors: Veronika
authors: V
authors: Stein
authors: Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Bünteweg 9, 30559, Hannover, Germany. Andrea.Tipold@tiho-hannover.de.
authors: Andrea
authors: A
authors: Tipold
authors: Department of Clinical Science and Services, Royal Veterinary College, Hatfield, AL9 7TA, Hertfordshire, UK. hvolk@rvc.ac.uk.
authors: Holger A
authors: HA
authors: Volk
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D038622:Internationality; D016896:Treatment Outcome; D014730:Veterinary Medicine / Q000458:organization & administration*
chemical_list: D000927:Anticonvulsants