title: Interference of Antimicrobial Activity of Combinations of Oral Antiseptics Against Streptococcus mutans, Streptococcus sanguinis, and Lactobacillus acidophilus.
abstract: OBJECTIVE
  The purpose of this study was to compare the effects of combinations of sodium fluoride and antiseptic compounds on the growth of Streptococcus mutans, Streptococcus sanguinis, and Lactobacillus acidophilus.
  
  
  METHODS
  The agar diffusion assay was used to determine bacterial growth inhibition.
  
  
  RESULTS
  Of the combinations tested, 0.1 percent sodium fluoride and five percent povidone iodine produced synergistic antibacterial effects against S. mutans and S. sanguinis. The combination of 10 percent povidone iodine and 0.5 percent sodium hypochlorite produced additive antibacterial effects against L. acidophilus. Interference was seen in some combinations such as 0.01 percent chlorhexidine and 0.25 percent sodium lauryl sulphate, 0.5 percent sodium hypochlorite and 10 percent povidone iodine, and 0.01 percent cetyl pyridium chloride and 0.1 percent sodium fluoride. However, 0.1 percent sodium fluoride combined with 0.01 percent chlorhexidine did not interfere with the antibacterial effects of chlorhexidine against S. mutans or S. sanguinis.
  
  
  CONCLUSIONS
  Combinations of common antiseptics and fluoride compounds can produce interference, synergistic, or additive effects. The combination of 0.1 percent sodium fluoride and five percent povidone iodine had the greatest potential for suppression of S. mutans.
authors: Centre for Paediatric Dentistry, University of Queensland, Brisbane, Australia.
authors: Alana
authors: A
authors: Evans
authors: Centre for Paediatric Dentistry, University of Queensland, Brisbane, Australia.
authors: Shaneen J
authors: SJ
authors: Leishman
authors: Centre for Paediatric Dentistry, University of Queensland, Brisbane, Australia.
authors: Laurence J
authors: LJ
authors: Walsh
authors: Centre for Paediatric Dentistry, University of Queensland, Brisbane, Australia. k.seow@uq.edu.au.
authors: W Kim
authors: WK
authors: Seow
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology*; D002594:Cetylpyridinium / Q000008:administration & dosage / Q000494:pharmacology; D002710:Chlorhexidine / Q000008:administration & dosage / Q000494:pharmacology; D004338:Drug Combinations; D004357:Drug Synergism; D006801:Humans; D007779:Lactobacillus acidophilus / Q000187:drug effects* / Q000254:growth & development; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000494:pharmacology; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000494:pharmacology; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology; D012973:Sodium Hypochlorite / Q000008:administration & dosage / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development; D013298:Streptococcus sanguis / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D012967:Sodium Dodecyl Sulfate; D011206:Povidone-Iodine; D012969:Sodium Fluoride; D002594:Cetylpyridinium; D012973:Sodium Hypochlorite; D002710:Chlorhexidine