title: The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review).
abstract: The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.
authors: The Finsen Laboratory, Rigshospitalet/BRIC, The University of Copenhagen, DK-2200 Copenhagen N, Denmark.
authors: Maria C
authors: MC
authors: Melander
authors: Proteases and Tissue Remodeling Section, Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, MD, USA.
authors: Henrik J
authors: HJ
authors: Jürgensen
authors: Proteases and Tissue Remodeling Section, Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, MD, USA.
authors: Daniel H
authors: DH
authors: Madsen
authors: The Finsen Laboratory, Rigshospitalet/BRIC, The University of Copenhagen, DK-2200 Copenhagen N, Denmark.
authors: Lars H
authors: LH
authors: Engelholm
authors: The Finsen Laboratory, Rigshospitalet/BRIC, The University of Copenhagen, DK-2200 Copenhagen N, Denmark.
authors: Niels
authors: N
authors: Behrendt
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D011975:Receptors, Mitogen / Q000378:metabolism*
chemical_list: C408294:Endo180; D011975:Receptors, Mitogen; D003094:Collagen