title: Applications of Ring Closing Metathesis. Total Synthesis of (±)-Pseudotabersonine.
abstract: A novel approach to theAspidospermafamily of alkaloids was developed and applied to a concise total synthesis of (±)-pseudotabersonine that was accomplished in 11 steps. Key transformations include a stepwise variant of a Mannich-like multicomponent assembly process, a double ring-closing metathesis sequence, and a one-pot deprotection/cyclization reaction.
authors: Department of Chemistry, The University of Texas at Austin, Austin, TX 78712.
authors: Bo
authors: B
authors: Cheng
authors: Department of Chemistry, The University of Texas at Austin, Austin, TX 78712.
authors: James D
authors: JD
authors: Sunderhaus
authors: Department of Chemistry, The University of Texas at Austin, Austin, TX 78712.
authors: Stephen F
authors: SF
authors: Martin
keywords: Alkaloid; Double ring-closing metathesis; Multicomponent assembly process; Total synthesis