title: [COMPREHENSIVE ASSESSMENT OF THE HEMOSTASIS SYSTEM IN TEST-SUBJECTS IN EXPERIMENT "MARS-500"].
abstract: The paper is devoted to the hemostasis studies in the course of long-term (520 d) isolation in an airtight chamber. Measured parameters included activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin time (TT); concentrations of fibrinogen (FBG), plasminogen (PG), Willebrand factor (WF), tissue factor pathway inhibitor (TFPI), and tissue plasminogen activator (TPA), thrombomodulin (TM); activities of the coagulation cascade factors (II, V, VII, X, VIII, IX, XI, XII), antithrombin III (ATIII), protein C (PC), C1-inhibitor (C1), α2-antiplasmin (AP), TPA and TFPI. The investigation revealed a diversity of changes in the plasma fibrinogen concentration, slower blood coagulation in the intrinsic pathway and the final stage, and a relative rise in the activities of ATIII and PC-inhibited factors. The rest parameters showed different trends.
authors: D S
authors: DS
authors: Kuzichkin
authors: A A
authors: AA
authors: Markin
authors: A L
authors: AL
authors: Vorontsov
authors: B V
authors: BV
authors: Morukov
authors: O A
authors: OA
authors: Zhuravleva
authors: I V
authors: IV
authors: Zabolotskaia
authors: L V
authors: LV
authors: Vostrikova
mesh_terms: D000328:Adult; D064368:Healthy Volunteers; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D013026:Space Flight; D018531:Spacecraft