title: Classification of different patterns of pulmonary adenocarcinomas.
abstract: The epidemic increase of adenocarcinoma histology accounting for more than 50% of primary lung malignancies and the advent of effective molecular targeted-therapies against specific gene alterations characterizing this tumor type have led to the reconsideration of the pathologic classification of lung cancer. The new 2015 WHO classification provided the basis for a multidisciplinary approach emphasizing the close correlation among clinical, radiologic and molecular characteristics and histopathologic pattern of lung adenocarcinoma. The terms 'bronchioloalveolar carcinoma' and 'mixed adenocarcinoma' have been eliminated, introducing the concepts of 'adenocarcinoma in situ', 'minimally invasive adenocarcinoma' and the use of descriptive predominant patterns in invasive adenocarcinomas (lepidic, acinar, papillary, solid and micropapillary patterns). 'Invasive mucinous adenocarcinoma' is the new definition for mucinous bronchioloalveolar carcinoma, and some variants of invasive adenocarcinoma have been included, namely colloid, enteric and fetal-type adenocarcinomas. A concise update of the immunomorphologic, radiological and molecular characteristics of the different histologic patterns of lung adenocarcinoma is reported here.
authors: a 1 Lung Cancer Unit, IRCCS AOU San Martino - IST and Dipartimento di Medicina Interna e Specialità Mediche (DIMI), Università di Genova, Genova, Italy.
authors: Anna
authors: A
authors: Truini
authors: b 2 Operative Unit of Pathologic Anatomy Hospital "Maggiore della Carità" of Novara, Novara, Italy.
authors: Poliana
authors: P
authors: Santos Pereira
authors: c 3 Department of Oncology and Advanced Technologies, Operative Unit of Oncology, Arcispedale S. Maria Nuova/ I.R.C.C.S., Reggio Emilia, Reggio Emilia, Italy.
authors: Alberto
authors: A
authors: Cavazza
authors: d 4 Medical University Clinic, Canton Hospital Baselland, and University of Basel, Basel, Switzerland.
authors: Paolo
authors: P
authors: Spagnolo
authors: e 5 Section of Pathologic Anatomy, University Hospital Policlinico of Modena, Modena, Italy.
authors: Sofia
authors: S
authors: Nosseir
authors: f 6 Medical Oncology Unit, Civic Hospital "Ramazzini", Carpi, Carpi, Italy.
authors: Lucia
authors: L
authors: Longo
authors: g 7 Pathology Institute, Pauls Stradins Clinical University Hospital, Riga, Riga, Latvia.
authors: Agita
authors: A
authors: Jukna
authors: h 8 Department of Surgery, Operative Unit of Thoracic Surgery, Arcispedale S. Maria Nuova/ I.R.C.C.S., Reggio Emilia, Reggio Emilia, Italy.
authors: Filippo
authors: F
authors: Lococo
authors: i 9 Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
authors: Giada
authors: G
authors: Vincenzi
authors: j 10 Section of Pathologic Anatomy, Hospital "Don Calabria", Negrar, Verona, Italy.
authors: Giuseppe
authors: G
authors: Bogina
authors: k 11 Division of Medical Oncology University Hospital, Parma, Italy.
authors: Marcello
authors: M
authors: Tiseo
authors: l 12 University Hospital of Modena, Modena, Italy.
authors: Giulio
authors: G
authors: Rossi
mesh_terms: D000230:Adenocarcinoma / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000473:pathology*
keywords: adenocarcinoma; epidermal growth factor receptor; ground-glass; immunohistochemistry; in-situ; lung; mucinous; pattern; thyroid transcription factor 1; v-ki-ras2 kirsten rat sarcoma viral oncogene homolog