title: Polysomnographic Assessment of Sleep Comorbidities in Drug-Naïve Narcolepsy-Spectrum Disorders--A Japanese Cross-Sectional Study.
abstract: This is a large cross-sectional study which aimed to investigate comorbidity rate, degree of sleep-related breathing disorder, polysomnigraphically diagnosible rapid eye movement sleep behavior disorder/rapid eye movement sleep without atonia and periodic limb movements during sleep in Japanese drug-naïve patients with narcolepsy-spectrum disorders. A total of 158 consecutive drug naïve patients with narcolepsy with cataplexy, 295 patients with narcolepsy without cataplexy and 395 patients with idiopathic hypersomnia without long sleep time were enrolled. From retrospectively analyzed data of nocturnal polysomnography and multiple sleep latency test, higher rates of periodic limb movements during sleep (> = 15 h(-1)) (10.2%) and polysomnographically diagnosable rapid eye movement sleep behavior disorder (1.9%) were found in patients with narcolepsy with cataplexy. They had more severe periodic limb movements during sleep especially during rapid eye movement sleep and higher percentages of rapid eye movement sleep without atonia than the other two patient groups. In the present large sample study, Japanese drug naïve patients with narcolepsy with cataplexy showed the highest comorbidity rates of periodic limb movements during sleep, polysomnographically diagnosable rapid eye movement sleep behavior disorder and rapid eye movement sleep without atonia among those with the other narcolepsy-spectrum disorders; the rates were lower than those for Western patients.
authors: Department of Somnology, Tokyo Medical University, Tokyo, Japan; Department of Life Sciences and Bio-informatics, Division of Biomedical Laboratory Sciences, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors: Taeko
authors: T
authors: Sasai-Sakuma
authors: Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan.
authors: Akihiko
authors: A
authors: Kinoshita
authors: Department of Somnology, Tokyo Medical University, Tokyo, Japan; Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan.
authors: Yuichi
authors: Y
authors: Inoue
mesh_terms: D000328:Adult; D044466:Asian People; D002385:Cataplexy / Q000453:epidemiology / Q000503:physiopathology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020177:Idiopathic Hypersomnia / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D009068:Movement / Q000502:physiology; D009290:Narcolepsy / Q000453:epidemiology* / Q000503:physiopathology; D017286:Polysomnography / Q000379:methods; D020187:REM Sleep Behavior Disorder / Q000453:epidemiology* / Q000503:physiopathology; D012189:Retrospective Studies; D012890:Sleep / Q000502:physiology; D012891:Sleep Apnea Syndromes / Q000453:epidemiology* / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology