title: Trace elements profile is associated with insulin resistance syndrome and oxidative damage in thyroid disorders: Manganese and selenium interest in Algerian participants with dysthyroidism.
abstract: The relationship between dysthyroidism and antioxidant trace elements (ATE) status is very subtle during oxidative stress (OS). This relationship is mediated by thyroid hormone (TH) disorder, insulin resistance syndrome (IRS) and inflammation. The aim of this study was to investigate ATE such as selenium (Se), manganese (Mn), zinc (Zn) and copper (Cu) status on thyroid dysfunction, and their interaction with antioxidant enzyme activities, mainly, superoxide dismutase (SOD) and glutathione peroxidase (GPx), TH profile (TSH, T(3), T(4)) and IRS clusters. The study was undertaken on 220 Algerian adults (30-50 years), including 157 women and 63 men who were divided to 4 groups: subclinical hypothyroidism (n = 50), overt hypothyroidism (n = 60), Graves's disease hyperthyroidism (n = 60) and euthyroid controls (n = 50). The IRS was confirmed according to NCEP (National Cholesterol Education Program). Insulin resistance was evaluated by HOMA-IR model. Trace elements were determined by the Flame Atomic Absorption Spectrometry (Flame-AAS) technique. The antioxidant enzymes activity and metabolic parameters were determined by biochemical methods. The TH profile and anti-Thyroperoxidase Antibodies (anti-TPO-Ab) were evaluated by radioimmunoassay. Results showed that the plasma manganese levels were significantly increased in all dysthyroidism groups (p ≤ 0.01). However, the plasma copper and zinc concentrations were maintained normal or not very disturbed vs control group. In contrast, the plasma selenium levels were highly decreased (p ≤ 0.001) and positively correlated with depletion of glutathione peroxidase activity; and associated both with anti-TPO-Ab overexpression and fulminant HS-CRP levels. This study confirms the oxidative stress-inflammation relationship in the dysthyroidism. The thyroid follicles antioxidant protection appears preserved in the cytosol (Cu/Zn-SOD), while it is altered in the mitochondria (Mn-SOD), which gives this cell organelle, a status of real target therapy in thyroid dysfunction. The publisher would like to apologise for any inconvenience caused. [corrected].
authors: Bioenergetics and Intermediary Metabolism team, Biology and Organisms Physiology laboratory, Biological Sciences Faculty, University of Sciences and Technology Houari Boumediene (USTHB), El Alia, Bab Ezzouar, 16123, Algiers, Algeria; Endocrinology exploration unit, Endocrinology department, Ibnou Ziri Bologhine University Hospital Center, Bainem, 16090, Algiers, Algeria. Electronic address: naimamaouche@yahoo.fr.
authors: Naima
authors: N
authors: Maouche
authors: Endocrinology exploration unit, Endocrinology department, Ibnou Ziri Bologhine University Hospital Center, Bainem, 16090, Algiers, Algeria. Electronic address: djamila.mes@voila.fr.
authors: Djamila
authors: D
authors: Meskine
authors: National Toxicology Center, Bab El Oued University Hospital Center, 16009, Algiers, Algeria. Electronic address: alamir.b@hotmail.com.
authors: Barkahoum
authors: B
authors: Alamir
authors: Bioenergetics and Intermediary Metabolism team, Biology and Organisms Physiology laboratory, Biological Sciences Faculty, University of Sciences and Technology Houari Boumediene (USTHB), El Alia, Bab Ezzouar, 16123, Algiers, Algeria. Electronic address: e.koceir@gmail.com.
authors: Elhadj-Ahmed
authors: EA
authors: Koceir
mesh_terms: D000328:Adult; D000462:Algeria; D000906:Antibodies / Q000097:blood; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D008345:Manganese / Q000097:blood*; D018384:Oxidative Stress; D009195:Peroxidase / Q000276:immunology; D012643:Selenium / Q000097:blood*; D013959:Thyroid Diseases / Q000097:blood* / Q000473:pathology*; D014131:Trace Elements / Q000097:blood*
chemical_list: D000906:Antibodies; D000975:Antioxidants; D015415:Biomarkers; D008055:Lipids; D014131:Trace Elements; D008345:Manganese; D009195:Peroxidase; D012643:Selenium
keywords: Dysthyroidism; Insulin Resistance Syndrome; Manganese; Oxidative stress; Selenium