title: [Modern Nanomedicine in Treatment of Lung Carcinomas].
abstract: BACKGROUND
  Despite the fast development of new effective cytostatics and targeted therapy, the treatment efficiency of lung cancer is still insufficient. The systemic administration of drugs results in a decrease in drug concentrations in tumor site, particularly due to specific extracellular environment in lungs. Nanotransporters could serve as a platform, protecting a drug against these undesired effects, which may enhance its therapeutic index and reduce side effects of a drug. Moreover, nanotechnologies possess the potential to improve the diagnostics of lung cancer, and thus increase a survival rate of oncologic patients.
  
  
  OBJECTIVE
  The presented study is aimed to demonstrate the possibilities provided by nanotechnologies in the field of treatment and diagnostic of lung cancers and discuss the obstacles, which complicate a translation into clinical practice.
authors: Z
authors: Z
authors: Heger
authors: T
authors: T
authors: Eckschlager
authors: M
authors: M
authors: Stiborová
authors: V
authors: V
authors: Adam
authors: O
authors: O
authors: Zítka
authors: R
authors: R
authors: Kizek
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D058990:Molecular Targeted Therapy; D050997:Nanomedicine