title: Polysaccharides of Trametes versicolor Improve Bone Properties in Diabetic Rats.
abstract: This study investigates the effects of Trametes versicolor (L.:Fr.) Pilát (TVP, also known as Yunzhi) on bone properties in diabetic rats. Forty-five male Wistar rats (8 weeks old) were fed either a chow diet (control) or a high-fat diet throughout the study period of 28 days. Animals in the high-fat-diet group were injected with nicotinamide and streptozotocin to induce diabetes mellitus (DM). The DM rats were divided into a group receiving distilled water (vehicle) and another group receiving TVP at 0.1 g/kg weight by gavage. Relative to the vehicle group, TVP gavage lowered postprandial blood sugar (225 ± 18 mg/dL for TVP vs 292 ± 15 mg/dL for vehicle, p < 0.001) on day 26. Compared to the vehicle group, TVP mitigated DM-induced bone deterioration as determined by increasing bone volume of proximal tibia (22.8 ± 1.4% for TVP vs 16.8 ± 1.3% for vehicle, p = 0.003), trabecular number (p = 0.011), and femoral bone strength (11% in maximal load, 22% in stiffness, 14% in modulus, p < 0.001), and by reducing loss of femoral cortical porosity by 25% (p < 0.001). Our study demonstrates the protective effect of TVP on bone properties was mediated through, in part, the improvement of hyperglycemic control in DM animals.
authors: Chung-Hwan
authors: CH
authors: Chen
authors: Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
authors: Lin
authors: L
authors: Kang
authors: Department of Nutritional Science, Fu Jen Catholic University , New Taipei City 510, Taiwan, Republic of China.
authors: Hui-Chen
authors: HC
authors: Lo
authors: Department of Bioindustry Technology and Department of Medicinal Botanicals and Health Care, Da-Yeh University , Dacun 515, Taiwan, Republic of China.
authors: Tai-Hao
authors: TH
authors: Hsu
authors: Department of Bioindustry Technology and Department of Medicinal Botanicals and Health Care, Da-Yeh University , Dacun 515, Taiwan, Republic of China.
authors: Fang-Yi
authors: FY
authors: Lin
authors: Yi-Shan
authors: YS
authors: Lin
authors: Zai-Jie
authors: ZJ
authors: Wang
authors: Department of Psychiatry, National Taiwan University Hospital Hsin-Chu Branch , Hsin Chu 300, Taiwan, Republic of China.
authors: Shih-Tse
authors: ST
authors: Chen
authors: Department of Pathology, Texas Tech University Health Sciences Center , 1A096B, 3601 4th Street, Lubbock, Texas 79430-8115, United States.
authors: Chwan-Li
authors: CL
authors: Shen
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001786:Blood Glucose / Q000378:metabolism; D001847:Bone Diseases / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D005269:Femur / Q000737:chemistry / Q000503:physiopathology; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D011134:Polysaccharides / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000737:chemistry / Q000503:physiopathology; D055454:Trametes / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D011134:Polysaccharides
keywords: Trametes versicolor; cortical porosity; diabetes; microarchitecture; polysaccharopeptides