title: Arsenic toxi-RNomics has the ability to tailor the host immune response.
abstract: Arsenic biology has caught the imagination of scientists across the globe because of its unique association with degenerative diseases in general and cancer in particular. Recent findings have added a new dimension to arsenic biology by revealing that most of the arsenic epigenomic effects are mediated through its ability to induce cellular miR-2909 expression at low doses. The present study was addressed to explore the molecular link that might exist between arsenic exposure, miR-2909 RNomics involving immunomodulatory genes and effector IgA class switching, revealed that arsenic-exposed Balb/c mice exhibited predominant Th1 immune response coupled with effector IgA class switching thereby tailoring their immune system to ensure increased risk to infections and chronic diseases like cancer.
authors: Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India; Department of Forensic Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors: S
authors: S
authors: Sharma
authors: Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India. Electronic address: dkaul235@gmail.com.
authors: D
authors: D
authors: Kaul
authors: Department of Forensic Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors: D
authors: D
authors: Singh
mesh_terms: D000818:Animals; D018053:Arsenites / Q000633:toxicity*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000633:toxicity; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D064368:Healthy Volunteers; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology*; D056747:Immunomodulation; D016130:Immunophenotyping; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017670:Sodium Compounds / Q000633:toxicity*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
chemical_list: D018053:Arsenites; D014408:Biomarkers, Tumor; D004791:Enzyme Inhibitors; C000589020:MIRN2909 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; D017670:Sodium Compounds; C017947:sodium arsenite
keywords: Arsenic; Balb/C mice; IgA class-switching; Immunomodulation; RNomics; miR-2909