title: Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.
abstract: BACKGROUND
  Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in the United States. Risk prediction based on identifying germline mutations in ovarian cancer susceptibility genes could have a clinically significant impact on reducing disease mortality.
  
  
  METHODS
  Next generation sequencing was used to identify germline mutations in the coding regions of four candidate susceptibility genes-BRIP1, BARD1, PALB2 and NBN-in 3236 invasive EOC case patients and 3431 control patients of European origin, and in 2000 unaffected high-risk women from a clinical screening trial of ovarian cancer (UKFOCSS). For each gene, we estimated the prevalence and EOC risks and evaluated associations between germline variant status and clinical and epidemiological risk factor information. All statistical tests were two-sided.
  
  
  RESULTS
  We found an increased frequency of deleterious mutations in BRIP1 in case patients (0.9%) and in the UKFOCSS participants (0.6%) compared with control patients (0.09%) (P = 1 x 10(-4) and 8 x 10(-4), respectively), but no differences for BARD1 (P = .39), NBN1 ( P = .61), or PALB2 (P = .08). There was also a difference in the frequency of rare missense variants in BRIP1 between case patients and control patients (P = 5.5 x 10(-4)). The relative risks associated with BRIP1 mutations were 11.22 for invasive EOC (95% confidence interval [CI] = 3.22 to 34.10, P = 1 x 10(-4)) and 14.09 for high-grade serous disease (95% CI = 4.04 to 45.02, P = 2 x 10(-5)). Segregation analysis in families estimated the average relative risks in BRIP1 mutation carriers compared with the general population to be 3.41 (95% CI = 2.12 to 5.54, P = 7×10(-7)).
  
  
  CONCLUSIONS
  Deleterious germline mutations in BRIP1 are associated with a moderate increase in EOC risk. These data have clinical implications for risk prediction and prevention approaches for ovarian cancer and emphasize the critical need for risk estimates based on very large sample sizes before genes of moderate penetrance have clinical utility in cancer prevention.
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Susan J
authors: SJ
authors: Ramus
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Honglin
authors: H
authors: Song
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Ed
authors: E
authors: Dicks
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Jonathan P
authors: JP
authors: Tyrer
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Adam N
authors: AN
authors: Rosenthal
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Maria P
authors: MP
authors: Intermaggio
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Lindsay
authors: L
authors: Fraser
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Aleksandra
authors: A
authors: Gentry-Maharaj
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Jane
authors: J
authors: Hayward
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Susan
authors: S
authors: Philpott
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Christopher
authors: C
authors: Anderson
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Christopher K
authors: CK
authors: Edlund
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: David
authors: D
authors: Conti
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Patricia
authors: P
authors: Harrington
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Daniel
authors: D
authors: Barrowdale
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: David D
authors: DD
authors: Bowtell
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Kathryn
authors: K
authors: Alsop
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Gillian
authors: G
authors: Mitchell
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Mine S
authors: MS
authors: Cicek
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Julie M
authors: JM
authors: Cunningham
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Brooke L
authors: BL
authors: Fridley
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Jennifer
authors: J
authors: Alsop
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Mercedes
authors: M
authors: Jimenez-Linan
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Samantha
authors: S
authors: Poblete
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Shashi
authors: S
authors: Lele
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Lara
authors: L
authors: Sucheston-Campbell
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Kirsten B
authors: KB
authors: Moysich
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Weiva
authors: W
authors: Sieh
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Valerie
authors: V
authors: McGuire
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Jenny
authors: J
authors: Lester
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Natalia
authors: N
authors: Bogdanova
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Matthias
authors: M
authors: Dürst
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Peter
authors: P
authors: Hillemanns
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Kunle
authors: K
authors: Odunsi
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Alice S
authors: AS
authors: Whittemore
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Beth Y
authors: BY
authors: Karlan
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Thilo
authors: T
authors: Dörk
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Ellen L
authors: EL
authors: Goode
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Usha
authors: U
authors: Menon
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Ian J
authors: IJ
authors: Jacobs
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Antonis C
authors: AC
authors: Antoniou
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Paul D P
authors: PD
authors: Pharoah
authors: Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, 
authors: Simon A
authors: SA
authors: Gayther
mesh_terms: D000328:Adult; D000368:Aged; D000077216:Carcinoma, Ovarian Epithelial; D018797:Cell Cycle Proteins / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D000076164:Fanconi Anemia Complementation Group N Protein; D051856:Fanconi Anemia Complementation Group Proteins; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008875:Middle Aged; D020125:Mutation, Missense; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000401:mortality; D009687:Nuclear Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000401:mortality; D011237:Predictive Value of Tests; D020365:RNA Helicases / Q000235:genetics*; D012306:Risk; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D014481:United States / Q000453:epidemiology; D044465:White People
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D000076164:Fanconi Anemia Complementation Group N Protein; D051856:Fanconi Anemia Complementation Group Proteins; C112156:NBN protein, human; D009687:Nuclear Proteins; C512790:PALB2 protein, human; D025521:Tumor Suppressor Proteins; C102449:BARD1 protein, human; D044767:Ubiquitin-Protein Ligases; C000618935:BRIP1 protein, human; D020365:RNA Helicases