title: Advances in Sepsis Research.
abstract: Recent research has identified promising targets for therapeutic interventions aimed at modulating the inflammatory response in sepsis. Herein, the authors describe mechanisms involved in the clearance of pathogen toxin from the circulation and potential interventions aimed at enhancing clearance mechanisms. The authors also describe advances in the understanding of the innate immune response as potential therapeutic targets. Finally, novel potential treatment strategies aimed at decreasing vascular leak are discussed.
authors: Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada; Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada; Department of Anesthesiology and Intensive Care, Lund University, Lund SE-221 85, Sweden.
authors: Peter
authors: P
authors: Bentzer
authors: Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada; Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada.
authors: James A
authors: JA
authors: Russell
authors: Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada; Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada. Electronic address: keith.walley@hli.ubc.ca.
authors: Keith R
authors: KR
authors: Walley
mesh_terms: D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018805:Sepsis / Q000276:immunology* / Q000473:pathology
keywords: Clearance; Edema; Innate immune receptors; Pathogen; Sepsis; Vascular leak