title: Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis.
abstract: OBJECTIVE
  To analyze the safety and efficacy of a nonselective cyclo-oxygenase (COX) inhibitor in the management of noninfectious, non-necrotizing anterior scleritis.
  
  
  METHODS
  Retrospective chart review of 126 patients with non-necrotizing anterior scleritis treated with oral flurbiprofen (Froben®(Abbott Healthcare)) with (Group B, n = 61) or without (Group A, n = 65) topical steroids was performed and time to remission was plotted.
  
  
  RESULTS
  The observed incidence rate was 1.07 (95% CI: 0.57-1.99) per 1000 person-years with failure rate of 0.68 (95% CI: 0.22-2.12) per 1000 person-years in Group A and 1.41 (95% CI: 0.67-2.96) per 1000 person-years in Group B. The failure rate was 3.97 (1.89-9.34) per 1000 person-years with hazard ratio of 10.01 (95% CI: 2.52-39.65; p < 0.001) for patients with associated systemic disease.
  
  
  CONCLUSIONS
  To the of our best knowledge, this is the first and largest case series on the safety and efficacy of a nonselective COX inhibitor in the management of anterior scleritis.
authors: a Moorfields Eye Hospital , London , UK .|b Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology , London , UK .|c National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore .
authors: Rupesh
authors: R
authors: Agrawal
authors: a Moorfields Eye Hospital , London , UK .|d University of Washington , Seattle , Washington , USA , and.
authors: Cecilia S
authors: CS
authors: Lee
authors: a Moorfields Eye Hospital , London , UK .|e Surgery Department , Universidad de Alcalá School of Medicine , Madrid , Spain.
authors: Julio J
authors: JJ
authors: Gonzalez-Lopez
authors: a Moorfields Eye Hospital , London , UK .
authors: Sharmina
authors: S
authors: Khan
authors: a Moorfields Eye Hospital , London , UK .
authors: Valeria
authors: V
authors: Rodrigues
authors: a Moorfields Eye Hospital , London , UK .|b Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology , London , UK .
authors: Carlos
authors: C
authors: Pavesio
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000869:Anterior Eye Segment / Q000187:drug effects*; D015331:Cohort Studies; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015423:Scleritis / Q000188:drug therapy*
chemical_list: D016861:Cyclooxygenase Inhibitors; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D005480:Flurbiprofen
keywords: COX-inhibitor; flurbiprofen; froben; non-necrotizing scleritis; noninfective; oral NSAIDs