title: Green approaches to late-stage fluorination: radiosyntheses of (18)F-labelled radiopharmaceuticals in ethanol and water.
abstract: Green strategies for late-stage fluorination with (18)F, in which ethanol and water are the only solvents used throughout the entire radiolabeling process (azeotropic drying, nucleophilic fluorination, purification and formulation), have been developed and applied to the radiosyntheses of a range of radiopharmaceuticals commonly employed in clinical PET imaging.
authors: Department of Medicinal Chemistry, College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109, USA.
authors: Megan N
authors: MN
authors: Stewart
authors: Brian G
authors: BG
authors: Hockley
authors: Peter J H
authors: PJ
authors: Scott
mesh_terms: D000431:Ethanol / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D014867:Water; D000431:Ethanol