title: Low Expression of the bcl2 Gene in Gastric Adenocarcinomas in Mazandaran Province of Iran.
abstract: BACKGROUND
  Gastric cancer accounts for about 8% of the total cancer cases and 10% of total cancer deaths worldwide. It is the second lethal cancer after esophageal cancer and is considered the fourth most common cancer in north and northwest Iran. The bcl2 family has a key role in the regulation of apoptosis and change in its expression can contribute to cancer. This study initially scheduled to determine the expression of bcl2 gene in tissue samples of adenocarcinoma cancer patients.
  
  
  METHODS
  A total of 10 samples of gastric adenocarcinoma and 10 of normal tissues from Sari hospital were selected and after DNA extraction from tissues, bcl2 gene expression assayed by real-time PCR.
  
  
  RESULTS
  Our results demonstrated higher expression of the bcl2 gene in control compared with cancer and marginal cancer tissues.
  
  
  CONCLUSIONS
  On one hand BCL2 plays an important role as an oncogene to inhibit apoptosis; on the other hand, it can initiate cell cycle arrest at G0 stage. Our observed association between its expression and patient survival is quite conflicting and may be tissue-specific. The data suggest expression both tumoural and non-tumoral(marginal) groups have lowered expression than controls (P>0.05). Due to the low number of samples we could not examine the relationship with clinicopathological features. However, bcl-2 expression may be important for prognostic outcome or a useful target for therapeutic intervention.
authors: Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Iran E-mail : raminataee1349@gmail.com.
authors: Seyedeh Habibeh
authors: SH
authors: Mirmajidi
authors: Ramin
authors: R
authors: Ataee
authors: Ali
authors: A
authors: Barzegar
authors: Novin
authors: N
authors: Nikbakhsh
authors: Mohammad
authors: M
authors: Shaterpour
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D005753:Gastric Mucosa / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007492:Iran / Q000453:epidemiology; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2