title: Independent association between brachial-ankle pulse wave velocity and global longitudinal strain of left ventricle.
abstract: Data regarding the influence of arterial stiffness on left ventricular (LV) long-axis function has been scarce. This study was performed to investigate the association between brachial-ankle pulse wave velocity (baPWV) and LV global longitudinal strain (GLS). A total of 248 subjects (mean age 59.2 ± 12.3 years; 50% were men) without structural heart problems were retrospectively evaluated. LV GLS was measured by 2-dimensional speckle-tracking echocardiography. baPWV measurements were made on the same day of echocardiography. The incidences of hypertension, diabetes mellitus, and dyslipidemia were 51.2, 19.4, and 22.2%, respectively. The mean value of baPWV was 1557 ± 285 cm/s. In simple linear regression analysis, baPWV had a significant positive association with LV GLS (β = 0.215, P = 0.001). In multiple linear regression analysis, baPWV was independently associated with LV GLS even after controlling for potential confounders, including age, gender, body mass index, systolic blood pressure, heart rate, HbA1c, total cholesterol, estimated glomerular filtration rate, left ventricular mass index, E/A, septal e' velocity and pulmonary artery systolic pressure (β = 0.211, P = 0.028). The results of this study suggest that baPWV may be independently associated with LV GLS, supporting the evidence of a close interaction between arterial stiffness and LV function. Increased arterial stiffness may result in impaired LV longitudinal function.
authors: Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, 39 Boramae-gil, Dongjak-gu, Seoul, 156-707, Korea.
authors: Hack-Lyoung
authors: HL
authors: Kim
authors: Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, 39 Boramae-gil, Dongjak-gu, Seoul, 156-707, Korea.
authors: Jae-Bin
authors: JB
authors: Seo
authors: Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, 39 Boramae-gil, Dongjak-gu, Seoul, 156-707, Korea.
authors: Woo-Young
authors: WY
authors: Chung
authors: Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, 39 Boramae-gil, Dongjak-gu, Seoul, 156-707, Korea.
authors: Sang-Hyun
authors: SH
authors: Kim
authors: Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, 39 Boramae-gil, Dongjak-gu, Seoul, 156-707, Korea.
authors: Myung-A
authors: MA
authors: Kim
authors: Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, 39 Boramae-gil, Dongjak-gu, Seoul, 156-707, Korea. jooheezo@hanmail.net.
authors: Joo-Hee
authors: JH
authors: Zo
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D055109:Ankle Brachial Index; D001696:Biomechanical Phenomena; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D018618:Echocardiography, Doppler, Color; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009200:Myocardial Contraction; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013314:Stress, Mechanical; D059289:Vascular Stiffness; D016277:Ventricular Function, Left
keywords: Arterial stiffness; Association; Brachial-ankle pulse wave velocity; Global longitudinal strain