title: Nanotechnology for treating osteoporotic vertebral fractures.
abstract: Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided.
authors: Department of Orthopaedic Surgery and Orthopaedic Institute, First Affiliated Hospital, Soochow University, Suzhou, People's Republic of China.
authors: Chunxia
authors: C
authors: Gao
authors: Department of Orthopaedic Surgery and Orthopaedic Institute, First Affiliated Hospital, Soochow University, Suzhou, People's Republic of China.
authors: Donglei
authors: D
authors: Wei
authors: Department of Orthopaedic Surgery and Orthopaedic Institute, First Affiliated Hospital, Soochow University, Suzhou, People's Republic of China.
authors: Huilin
authors: H
authors: Yang
authors: Robotics and Microsystems Center, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, People's Republic of China.
authors: Tao
authors: T
authors: Chen
authors: Department of Orthopaedic Surgery and Orthopaedic Institute, First Affiliated Hospital, Soochow University, Suzhou, People's Republic of China ; Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors: Lei
authors: L
authors: Yang
mesh_terms: D001672:Biocompatible Materials; D001843:Bone Cements; D006801:Humans; D050997:Nanomedicine; D049329:Nanostructures; D010024:Osteoporosis / Q000628:therapy*; D016103:Spinal Fractures / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements
keywords: bone cement; kyphoplasty; nanomaterials; osteoporosis; pedicle screw; radiopacifier; vertebral fracture