title: New insights from monogenic diabetes for "common" type 2 diabetes.
abstract: Boundaries between monogenic and complex genetic diseases are becoming increasingly blurred, as a result of better understanding of phenotypes and their genetic determinants. This had a large impact on the way complex disease genetics is now being investigated. Starting with conventional approaches like familial linkage, positional cloning and candidate genes strategies, the scope of complex disease genetics has grown exponentially with scientific and technological advances in recent times. Despite identification of multiple loci harboring common and rare variants associated with complex diseases, interpreting and evaluating their functional role has proven to be difficult. Information from monogenic diseases, especially related to the intermediate traits associated with complex diseases comes handy. The significant overlap between traits and phenotypes of monogenic diseases with related complex diseases provides a platform to understand the disease biology better. In this review, we would discuss about one such complex disease, type 2 diabetes, which shares marked similarity of intermediate traits with different forms of monogenic diabetes.
authors: Genomic Research on Complex Diseases Laboratory, Council of Scientific and Industrial Research-Centre for Cellular and Molecular Biology Hyderabad, India.
authors: Divya Sri Priyanka
authors: DS
authors: Tallapragada
authors: Genomic Research on Complex Diseases Laboratory, Council of Scientific and Industrial Research-Centre for Cellular and Molecular Biology Hyderabad, India.
authors: Seema
authors: S
authors: Bhaskar
authors: Genomic Research on Complex Diseases Laboratory, Council of Scientific and Industrial Research-Centre for Cellular and Molecular Biology Hyderabad, India.
authors: Giriraj R
authors: GR
authors: Chandak
keywords: complex diseases; maturity onset diabetes of the young; monogenic diabetes; simple/Mendelian diseases; type 2 diabetes