title: Bordetella pertussis evolution in the (functional) genomics era.
abstract: The incidence of whooping cough caused by Bordetella pertussis in many developed countries has risen dramatically in recent years. This has been linked to the use of an acellular pertussis vaccine. In addition, it is thought that B. pertussis is adapting under acellular vaccine mediated immune selection pressure, towards vaccine escape. Genomics-based approaches have revolutionized the ability to resolve the fine structure of the global B. pertussis population and its evolution during the era of vaccination. Here, we discuss the current picture of B. pertussis evolution and diversity in the light of the current resurgence, highlight import questions raised by recent studies in this area and discuss the role that functional genomics can play in addressing current knowledge gaps.
authors: Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
authors: Thomas
authors: T
authors: Belcher
authors: Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK a.preston@bath.ac.uk.
authors: Andrew
authors: A
authors: Preston
mesh_terms: D001886:Bordetella pertussis / Q000145:classification* / Q000235:genetics* / Q000276:immunology; D019143:Evolution, Molecular; D014644:Genetic Variation; D016680:Genome, Bacterial; D023281:Genomics; D014943:Global Health; D006801:Humans; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology; D012641:Selection, Genetic; D014917:Whooping Cough / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control
chemical_list: D010567:Pertussis Vaccine
keywords: Bordetella pertussis; diversity; evolution; genomics