title: Designer probiotics: Development and applications in gastrointestinal health.
abstract: Given the increasing commercial and clinical relevance of probiotics, improving their stress tolerance profile and ability to overcome the physiochemical defences of the host is an important biological goal. Herein, I review the current state of the art in the design of engineered probiotic cultures, with a specific focus on their utility as therapeutics for the developing world; from the treatment of chronic and acute enteric infections, and their associated diarrhoeal complexes, to targeting HIV and application as novel mucosal vaccine delivery vehicles.
authors: Roy D Sleator, Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland.
authors: Roy D
authors: RD
authors: Sleator
keywords: BetL; Bifidobacterium; Gastrointestinal tract; Lactobacillus; Listeria monocytogenes; Probiotics