title: Biogenesis, delivery, and function of extracellular RNA.
abstract: The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by recipient cells remain to be determined. This review will summarize current knowledge about the biogenesis and delivery of exRNA and outline projects seeking to understand the functional impact of exRNA.
authors: Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA; James.G.Patton@Vanderbilt.edu.
authors: James G
authors: JG
authors: Patton
authors: VA Medical Center, Nashville, TN, USA.|Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.|Department of Medicine, Vanderbilt University, Nashville, TN, USA.
authors: Jeffrey L
authors: JL
authors: Franklin
authors: VA Medical Center, Nashville, TN, USA.|Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA.
authors: Alissa M
authors: AM
authors: Weaver
authors: Department of Cardiology, Vanderbilt University, Nashville, TN, USA.
authors: Kasey
authors: K
authors: Vickers
authors: Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
authors: Bing
authors: B
authors: Zhang
authors: VA Medical Center, Nashville, TN, USA.|Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.|Department of Medicine, Vanderbilt University, Nashville, TN, USA.
authors: Robert J
authors: RJ
authors: Coffey
authors: Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA.|Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA, USA.
authors: K Mark
authors: KM
authors: Ansel
authors: Department of Urology, University of California San Francisco, San Francisco, CA, USA.|Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
authors: Robert
authors: R
authors: Blelloch
authors: Department of Cell & Tissue Biology, University of California San Francisco, San Francisco, CA, USA.|Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
authors: Andrei
authors: A
authors: Goga
authors: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.|Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
authors: Bo
authors: B
authors: Huang
authors: Department of Cell & Tissue Biology, University of California San Francisco, San Francisco, CA, USA.
authors: Noelle
authors: N
authors: L'Etoille
authors: Department of Surgery, University of California San Francisco, San Francisco, CA, USA.|VA Medical Center, San Francisco, CA, USA.
authors: Robert L
authors: RL
authors: Raffai
authors: Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
authors: Charles P
authors: CP
authors: Lai
authors: Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors: Anna M
authors: AM
authors: Krichevsky
authors: Swiss Federal Institute of Technology Zürich (ETH Zürich), Zürich, Switzerland.
authors: Bogdan
authors: B
authors: Mateescu
authors: Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA.|Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
authors: Vanille J
authors: VJ
authors: Greiner
authors: Harvard University, Cambridge, MA, USA.
authors: Craig
authors: C
authors: Hunter
authors: Swiss Federal Institute of Technology Zürich (ETH Zürich), Zürich, Switzerland.
authors: Olivier
authors: O
authors: Voinnet
authors: Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA.|Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
authors: Michael T
authors: MT
authors: McManus
keywords: ERCC; exRNA; extracellular RNA