title: Skin microvascular endothelial function as a biomarker in cardiovascular diseases?
abstract: Skin microvascular endothelial function is impaired in many cardiovascular diseases, and could be therefore considered as a representative vascular bed. However, today, available evidence allows considering skin microvascular endothelial function neither as a diagnostic biomarker nor as a prognostic biomarker in cardiovascular diseases. Large follow-up studies using standardized methods should now be conducted to assess the potential predictive value of skin microvascular function in cardiovascular diseases.
authors: Inserm CIC1406, Clinical Pharmacology Department, University Hospital, Grenoble, France; Noninvasive Cardiac Diagnostics Department, Medical University, Gdańsk, Poland. Electronic address: marcin.hellmann@gmail.com.
authors: Marcin
authors: M
authors: Hellmann
authors: Inserm CIC1406, Clinical Pharmacology Department, University Hospital, Grenoble, France; Inserm HP2, Grenoble, France; Univ Grenoble-Alpes, Grenoble, France.
authors: Matthieu
authors: M
authors: Roustit
authors: Inserm CIC1406, Clinical Pharmacology Department, University Hospital, Grenoble, France; Inserm HP2, Grenoble, France; Univ Grenoble-Alpes, Grenoble, France.
authors: Jean-Luc
authors: JL
authors: Cracowski
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000503:physiopathology; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000473:pathology* / Q000502:physiology*; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods; D055806:Microvessels / Q000473:pathology*; D016032:Randomized Controlled Trials as Topic; D012867:Skin / Q000098:blood supply* / Q000473:pathology; D014664:Vasodilation / Q000502:physiology
keywords: Endothelium; Laser Doppler; Laser speckle contrast imaging; Reactivity tests; Skin microcirculation