title: Comparative in vitro activity of oral antimicrobial agents against Enterobacteriaceae from patients with community-acquired urinary tract infections in three European countries.
abstract: Enterobacteriaceae causing community-acquired urinary tract infections were examined in selected outpatient clinics and hospitals in Belgium, Germany and Spain using EUCAST breakpoints for susceptibility. A total of 1190 isolates were collected. Escherichia coli isolates were resistant to amoxicillin-clavulanic acid (28.1%), ciprofloxacin (23.4%) and trimethoprim-sulfamethoxazole (21.4%) compared with fosfomycin and nitrofurantoin (each, <1.5%). Ceftibuten (MIC50/90 0.25/0.5 mg/L) and ceftriaxone activity (MIC50/90 ≤0.25 mg/L) was comparable. Ceftibuten (MIC90 ≤0.25 mg/L) was also active against Proteus mirabilis and Klebsiella spp. Extended-spectrum β-lactamase phenotypes were 7.1% for E. coli, 5.6% for Klebsiella pneumoniae and 0.4% for P. mirabilis. Resistance was common among men and elderly women.
authors: Antiinfectives Intelligence GmbH, Rheinbach, Germany. Electronic address: michael.kresken@antiinfectives-intelligence.de.
authors: M
authors: M
authors: Kresken
authors: Antiinfectives Intelligence GmbH, Rheinbach, Germany.
authors: B
authors: B
authors: Körber-Irrgang
authors: International Health Management Associates, Inc., Schaumburg, IL, USA.
authors: D J
authors: DJ
authors: Biedenbach
authors: Servicio de Microbiología-Hospital Universitario Virgen Macarena, Seville, Spain.
authors: N
authors: N
authors: Batista
authors: Practimed CVBA Clinical Laboratory, Tessenderlo, Belgium.
authors: V
authors: V
authors: Besard
authors: Servicio de Microbiología. Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
authors: R
authors: R
authors: Cantón
authors: Servicio de Microbiología. Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
authors: M
authors: M
authors: García-Castillo
authors: Medizinisches Versorgungszentrum Dr. Stein & Kollegen, Mönchengladbach, Germany.
authors: W
authors: W
authors: Kalka-Moll
authors: Servicio de Microbiología-Hospital Universitario Virgen Macarena, Seville, Spain.
authors: A
authors: A
authors: Pascual
authors: Medizinisches Versorgungszentrum Dr. Stein & Kollegen, Mönchengladbach, Germany.
authors: R
authors: R
authors: Schwarz
authors: MCH Leuven, Leuven, Belgium.
authors: B
authors: B
authors: Van Meensel
authors: Laboratoriumsmedizin Köln Dres. med. Wisplinghoff & Kollegen, Cologne, Germany.
authors: H
authors: H
authors: Wisplinghoff
authors: Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany; German Centre for Infection Research, Bonn-Cologne, Germany.
authors: H
authors: H
authors: Seifert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000554:Ambulatory Care Facilities; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001530:Belgium; D017714:Community-Acquired Infections / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D013030:Spain; D014552:Urinary Tract Infections / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents
keywords: Age; cephalosporin; extended-spectrum β-lactamase rates; gender; resistance