title: Comparison of the risk of surgical site infection and feasibility of surgery between sennoside versus polyethylene glycol as a mechanical bowel preparation of elective colon cancer surgery: a randomized controlled trial.
abstract: OBJECTIVE
  To validate the usefulness of sennoside as a substitute for polyethylene glycol (PEG) as a mechanical bowel preparation (MBP) for elective colon cancer surgery.
  
  
  METHODS
  We performed a prospective randomized non-inferiority trial comparing the use of sennoside and PEG in MBP for elective colon cancer surgery, in terms of the risk of surgical site infection (SSI) and the feasibility of surgery.
  
  
  RESULTS
  The overall incidence of SSIs was 2.9 % in the sennoside group (n = 68) and 6.3 % in the PEG group (n = 63) with a difference of 3.4 % (95 % confidence interval 6.9-10.6 %). The intraoperative spillage of the stool materials in the sennoside and PEG groups was 4.4 and 3.1 %, respectively, and was not significantly different (p = 0.71), even the upstream stool consistency, was more frequently observed to be non-stool in the PEG group (65.1 vs. 30.9 %, p < 0.01).
  
  
  CONCLUSIONS
  MBP with sennoside could be a substitution for PEG in elective colon cancer surgery.
authors: Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan. tajifeyfey@yahoo.co.jp.
authors: Yusuke
authors: Y
authors: Tajima
authors: Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
authors: Hideyuki
authors: H
authors: Ishida
authors: Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
authors: Azusa
authors: A
authors: Yamamoto
authors: Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
authors: Noriyasu
authors: N
authors: Chika
authors: Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
authors: Hisashi
authors: H
authors: Onozawa
authors: Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
authors: Takeaki
authors: T
authors: Matsuzawa
authors: Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
authors: Kensuke
authors: K
authors: Kumamoto
authors: Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
authors: Keiichiro
authors: K
authors: Ishibashi
authors: Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
authors: Erito
authors: E
authors: Mochiki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002400:Cathartics; D003110:Colonic Neoplasms / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000379:methods*; D017558:Elective Surgical Procedures / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D011446:Prospective Studies; D012306:Risk; D018401:Sample Size; D012676:Senna Extract; D000081226:Sennosides; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D002400:Cathartics; D000081226:Sennosides; D011092:Polyethylene Glycols; D012676:Senna Extract
keywords: Colon cancer; Mechanical bowel preparation; Polyethylene glycol; Sennoside