title: miR-142-3p is a Potential Therapeutic Target for Sensory Function Recovery of Spinal Cord Injury.
abstract: Spinal cord injury (SCI), which is a leading cause of disability in modern society, commonly results from trauma. It has been reported that application of sciatic nerve conditioning injury plays a positive role in repairing the injury of the ascending spinal sensory pathway in laboratory animals. Because of the complexity of SCI and related ethics challenges, sciatic nerve conditioning injury cannot be applied in clinical therapy. Accordingly, it is extremely important to study its mechanism and develop replacement therapy. Based on empirical study and clinical trials, this article suggests that miR-142-3p is the key therapeutic target for repairing sensory function, based on the following evidence. Firstly, studies have reported that endogenous cAMP is the upstream regulator of 3 signal pathways that are partially involved in the mechanisms of sciatic nerve conditioning injury, promoting neurite growth. The regulated miR-142-3p can induce cAMP elevation via adenylyl cyclase 9 (AC9), which is abundant in dorsal root ganglia (DRG). Secondly, compared with gene expression regulation in the injured spinal cord, inhibition of microRNA (miRNA) in DRG is less likely to cause trauma and infection. Thirdly, evidence of miRNAs as biomarkers and therapeutic targets in many diseases has been reported. In this article we suggest, for the first time, imitating sciatic nerve conditioning injury, thereby enhancing central regeneration of primary sensory neurons via interfering with the congenerous upstream regulator AC9 of the 3 above-mentioned signal pathways. We hope to provide a new clinical treatment strategy for the recovery of sensory function in SCI patients.
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China (mainland).
authors: Tianyi
authors: T
authors: Wang
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China (mainland).
authors: Wenqi
authors: W
authors: Yuan
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China (mainland).
authors: Yong
authors: Y
authors: Liu
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China (mainland).
authors: Yanjun
authors: Y
authors: Zhang
authors: Department of Pediatric Internal Medicine, Affiliated Hospital of Chengde Medical College, Chengde, Hebei, China (mainland).
authors: Zhijie
authors: Z
authors: Wang
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China (mainland).
authors: Xueming
authors: X
authors: Chen
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China (mainland).
authors: Shiqing
authors: S
authors: Feng
authors: Department of Orthopedics, The 266th Hospital of the Chinese People's Liberation Army, Chengde, Hebei, China (mainland).
authors: Yucai
authors: Y
authors: Xiu
authors: Department of Orthopedics, The 266th Hospital of the Chinese People's Liberation Army, Chengde, Hebei, China (mainland).
authors: Wenhua
authors: W
authors: Li
mesh_terms: D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*
chemical_list: C555159:MIRN142 microRNA, human; D035683:MicroRNAs; D000242:Cyclic AMP