title: [Successful Hematopoietic Cell Transplantation Following Azacitidine Treatment in an Acute Myeloid Leukemia Patient with t(3;3)(q21;q26.2) Translocation and Marked Thrombocythemia].
abstract: A 39-year-old man visited our department complaining of general malaise and appetite loss. He presented with anemia and marked thrombocythemia; his plasma transforming growth factor (TGF)-b concentration was markedly increased and his thrombopoietin (TPO)concentration was decreased. Since the patient's disease had progressed to acute myeloid leukemia (AML) with an increase in the peripheral blast count, he was diagnosed with AML along with t(3;3) (q21;q26.2) through a bone marrow aspiration sample. Remission induction therapy was performed using idarubicin/cytarabine. The patient achieved complete remission. His platelet count returned to the normal range, plasma TGF-b concentration decreased, and serum TPO concentration increased. The patient was treated with azacitidine as post-remission therapy for bone marrow transplantation, following which he underwent allogeneic hematopoietic cell transplantation.
authors: Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital.
authors: Masahiro
authors: M
authors: Yoshida
authors: Hiroyuki
authors: H
authors: Kuroda
authors: Saori
authors: S
authors: Shimoyama
authors: Makoto
authors: M
authors: Usami
authors: Michiko
authors: M
authors: Yamada
authors: Shigeyuki
authors: S
authors: Fujii
authors: Masahiro
authors: M
authors: Maeda
authors: Miri
authors: M
authors: Fujita
authors: Yusuke
authors: Y
authors: Kanari
authors: Masanori
authors: M
authors: Sato
authors: Wataru
authors: W
authors: Jomen
authors: Satoshi
authors: S
authors: Iyama
authors: Junji
authors: J
authors: Kato
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001374:Azacitidine / Q000627:therapeutic use*; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy*; D008297:Male; D014178:Translocation, Genetic
chemical_list: D000964:Antimetabolites, Antineoplastic; D001374:Azacitidine