title: Polymer/Iron Oxide Nanoparticle Composites--A Straight Forward and Scalable Synthesis Approach.
abstract: Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.
authors: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. jens.sommertune@sp.se.
authors: Jens
authors: J
authors: Sommertune
authors: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. abhilash.sugunan@sp.se.
authors: Abhilash
authors: A
authors: Sugunan
authors: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. anwar.ahniyaz@sp.se.
authors: Anwar
authors: A
authors: Ahniyaz
authors: Department of Engineering Sciences, Solid State Physics, Uppsala University, SE-751 21 Uppsala, Sweden. Rebecca.Bejhed@angstrom.uu.se.
authors: Rebecca Stjernberg
authors: RS
authors: Bejhed
authors: Acreo Swedish ICT AB, Box 53071, SE-400 14 Göteborg, Sweden. Anna.Sarwe@acreo.se.
authors: Anna
authors: A
authors: Sarwe
authors: Acreo Swedish ICT AB, Box 53071, SE-400 14 Göteborg, Sweden. Christer.Johansson@acreo.se.
authors: Christer
authors: C
authors: Johansson
authors: Institute of Electrical Measurement and Fundamental Electrical Engineering, TU Braunschweig, D-38106 Braunschweig, Germany. c.balceris@tu-bs.de.
authors: Christoph
authors: C
authors: Balceris
authors: Institute of Electrical Measurement and Fundamental Electrical Engineering, TU Braunschweig, D-38106 Braunschweig, Germany. f.ludwig@tu-bs.de.
authors: Frank
authors: F
authors: Ludwig
authors: Physikalisch-Technische Bundesanstalt, 10587 Berlin, Germany. oliver.posth@ptb.de.
authors: Oliver
authors: O
authors: Posth
authors: SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden. andrea.fornara@sp.se.
authors: Andrea
authors: A
authors: Fornara
mesh_terms: D005290:Ferric Compounds / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D011108:Polymers; C000499:ferric oxide
keywords: iron oxide nanoparticle; multi core; nanocomposite; polymer encapsulation; single core