title: Studies toward the AB ring system of the tetrapetalone natural products.
abstract: Synthetic efforts toward the rapid assembly of the AB ring system of the tetrapetalones is described. Key to this work was the use of [3+2] cycloaddition/oxidative extrusion methodology to furnish functionalized aryl enones. The Nazarov cyclization of these substrates was examined, and optimized to generate the AB ring carbon skeleton. Then, Pd-catalyzed cross-coupling were conducted, and conditions were identified that enabled installation of the requisite C14-N bond.
authors: Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.
authors: Peter
authors: P
authors: Carlsen
authors: Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.
authors: Chao
authors: C
authors: Jiang
authors: Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.
authors: Ildiko R
authors: IR
authors: Herrick
authors: Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.
authors: Alison J
authors: AJ
authors: Frontier
keywords: Cross-coupling; Cyclization; Natural Products; Polycycles