title: Predictive value of thrombospondin-1 for outcomes in patients with acute ischemic stroke.
abstract: BACKGROUND
  Thrombospondin-1 is a potent regulator of angiogenesis. The expression of cerebral thrombospondin-1 is promoted in a rat model of intracerebral hemorrhage. The current study was designed to investigate the change of plasma thrombospondin-1 concentrations and assess the prognostic value of plasma thrombospondin-1 concentrations for long-term mortality and functional outcome of ischemic stroke patients.
  
  
  METHODS
  This study included 192 patients and 150 healthy controls. The plasma thrombospondin-1 concentrations were measured using enzyme-linked immunosorbent assay. An unfavorable outcome was defined as a modified Rankin Scale score >3. The relationships between plasma thrombospondin-1 concentrations and 6-month clinical outcomes were analyzed using multivariate analysis.
  
  
  RESULTS
  Compared with healthy controls, plasma thrombospondin-1 concentrations were statistically significantly elevated in patients. Using multivariate analysis, thrombospondin-1 emerged as an independent predictor for 6-month mortality, 6-month unfavorable outcome and 6-month overall survival. Plasma thrombospondin-1 concentrations possessed high predictive values under receiver operating characteristic curve. Their predictive values were similar to those of National Institutes of Health Stroke Scale scores.
  
  
  CONCLUSIONS
  Plasma thrombospondin-1 concentrations are elevated obviously and are highly associated with long-term outcome of ischemic stroke.
authors: Department of Emergency Medicine, Fuyang People's Hospital, 2-4 Guihua Road, Fuyang 311400, Zhejiang Province, China. Electronic address: FangLongZhu@yeah.net.
authors: Jian-Bo
authors: JB
authors: Gao
authors: Department of Critical Care Medicine, Fuyang People's Hospital, 2-4 Guihua Road, Fuyang 311400, Zhejiang Province, China.
authors: Wei-Dong
authors: WD
authors: Tang
authors: Department of Neurology, Fuyang People's Hospital, 2-4 Guihua Road, Fuyang 311400, Zhejiang Province, China.
authors: Hong-Xiang
authors: HX
authors: Wang
authors: Department of Neurology, Fuyang People's Hospital, 2-4 Guihua Road, Fuyang 311400, Zhejiang Province, China.
authors: Yan
authors: Y
authors: Xu
mesh_terms: D000208:Acute Disease; D000368:Aged; D002545:Brain Ischemia / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D020521:Stroke / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D019700:Thrombospondin 1 / Q000097:blood*
chemical_list: D019700:Thrombospondin 1
keywords: Biomarker; Ischemic stroke; Prognosis; Thrombospondin-1