title: Mutated JAK kinases and deregulated STAT activity are potential therapeutic targets in cutaneous T-cell lymphoma.
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain.
authors: Cristina
authors: C
authors: Pérez
authors: Lymphoma Research Group (Medical Oncology Service) Oncohematology Area, Instituto Investigación Sanitaria Puerta de Hierro-Majadahonda (IDIPHIM), Madrid, Spain.
authors: Julia
authors: J
authors: González-Rincón
authors: Pathology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
authors: Arantza
authors: A
authors: Onaindia
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain.
authors: Carmen
authors: C
authors: Almaráz
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain.
authors: Nuria
authors: N
authors: García-Díaz
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain.
authors: Helena
authors: H
authors: Pisonero
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain.
authors: Soraya
authors: S
authors: Curiel-Olmo
authors: Lymphoma Research Group (Medical Oncology Service) Oncohematology Area, Instituto Investigación Sanitaria Puerta de Hierro-Majadahonda (IDIPHIM), Madrid, Spain.
authors: Sagrario
authors: S
authors: Gómez
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain.
authors: Laura
authors: L
authors: Cereceda
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain.
authors: Rebeca
authors: R
authors: Madureira
authors: Dermatology Service, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
authors: Mercedes
authors: M
authors: Hospital
authors: Pathology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
authors: Dolores
authors: D
authors: Suárez-Massa
authors: Pathology Department, Institute i+12, Medical School, Universidad Complutense de Madrid, Spain.
authors: José L
authors: JL
authors: Rodriguez-Peralto
authors: Dermatology Service, Institute i+12, Medical School, Universidad Complutense de Madrid, Spain.
authors: Concepción
authors: C
authors: Postigo
authors: Pathology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
authors: Alicia
authors: A
authors: Leon-Castillo
authors: Pathology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
authors: Carmen
authors: C
authors: González-Vela
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain.
authors: Nerea
authors: N
authors: Martinez
authors: Dermatology Service, Institute i+12, Medical School, Universidad Complutense de Madrid, Spain.
authors: Pablo
authors: P
authors: Ortiz-Romero
authors: Lymphoma Research Group (Medical Oncology Service) Oncohematology Area, Instituto Investigación Sanitaria Puerta de Hierro-Majadahonda (IDIPHIM), Madrid, Spain.
authors: Margarita
authors: M
authors: Sánchez-Beato
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain Pathology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
authors: Miguel Á
authors: MÁ
authors: Piris
authors: Cancer Genomics Laboratory Instituto de Investigación Maques de Valdecilla, IDIVAL, Santander, Spain Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (CSIC, Universidad de Cantabria), Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain vaquej@unican.es.
authors: José P
authors: JP
authors: Vaqué
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053612:Janus Kinases / Q000235:genetics* / Q000378:metabolism*; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics*
chemical_list: D050791:STAT Transcription Factors; D053612:Janus Kinases
keywords: CTCL; JAK mutations; JAK/STAT; molecular diagnostics; ruxolitinib; targeted therapy