title: PGE2, Kidney Disease, and Cardiovascular Risk: Beyond Hypertension and Diabetes.
abstract: An important measure of cardiovascular health is obtained by evaluating the global cardiovascular risk, which comprises a number of factors, including hypertension and type 2 diabetes, the leading causes of illness and death in the world, as well as the metabolic syndrome. Altered immunity, inflammation, and oxidative stress underlie many of the changes associated with cardiovascular disease, diabetes, and the metabolic syndrome, and recent efforts have begun to elucidate the contribution of PGE2 in these events. This review summarizes the role of PGE2 in kidney disease outcomes that accelerate cardiovascular disease, highlights the role of cyclooxygenase-2/microsomal PGE synthase 1/PGE2 signaling in hypertension and diabetes, and outlines the contribution of PGE2 to other aspects of the metabolic syndrome, particularly abdominal adiposity, dyslipidemia, and atherogenesis. A clearer understanding of the role of PGE2 could lead to new avenues to improve therapeutic options and disease management strategies.
authors: Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors: Rania
authors: R
authors: Nasrallah
authors: Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors: Ramzi
authors: R
authors: Hassouneh
authors: Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada rlhebert@uottawa.ca.
authors: Richard L
authors: RL
authors: Hébert
mesh_terms: D050153:Abdominal Fat; D050197:Atherosclerosis / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D050171:Dyslipidemias / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D019746:Intramolecular Oxidoreductases / Q000378:metabolism; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism*; D000071876:Prostaglandin-E Synthases; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051546:Cyclooxygenase 2; D019746:Intramolecular Oxidoreductases; C000605862:PTGES protein, human; D000071876:Prostaglandin-E Synthases; D015232:Dinoprostone
keywords: BP; cardiovascular disease; chronic renal failure; chronic renal insufficiency; diabetes; kidney disease