title: Association of APOA5 T1131C polymorphism and risk of coronary artery disease.
abstract: OBJECTIVE
  Our research aimed to investigate the relationship between Apolipoprotein A5 (APOA5) T1131C polymorphism and the risk of coronary artery disease (CAD).
  
  
  METHODS
  We searched the relevant articles in databases and 25 ones were chosen. The association between APOA5 T1131C polymorphism and CAD risk was evaluated using odds ratios (ORs) and 95% confidence intervals (95% CIs). The fixed-effect model or random-effect model was applied according to the heterogeneity analysis.
  
  
  RESULTS
  Overall, significant association between CAD risk and APOA5 T1131C polymorphism was found (CC vs. TT: OR=1.47, 95% CI=1.22-1.78; CC+TC vs. TT: OR=1.13, 95% CI=1.07-1.20; CC vs. TT+TC: OR=1.37, 95% CI=1.13-1.66; allele C vs. allele T: OR=1.17, 95% CI=1.09-1.25; TC vs. TT: OR=1.12, 95% CI=1.06-1.20). In the ethnicity subgroup analysis, risk of CAD was observed in all genotypes among Asians (CC vs. TT: OR=1.40, 95% CI=1.17-1.68; CC+TC vs. TT: OR=1.13, 95% CI=1.06-1.20; CC vs. TT+TC: OR=1.30, 95% CI=1.08-1.56; allele C vs. allele T: OR=1.15, 95% CI=1.08-1.24; TC vs. TT: OR=1.13, 95% CI=1.06-1.21), While in Caucasians, the similar association was only found in several genotypes. In the subgroup analysis by source of control, we found that APOA5 T1131C polymorphism could increase the risk of CAD in population-based (PB) genetic group (CC vs. TT: OR=1.54, 95% CI=1.29-1.84; CC+TC vs. TT: OR=1.15, 95% CI=1.08-1.23; CC vs. TT+TC: OR=1.45, 95% CI=1.19-1.76; allele C vs. allele T: OR=1.19, 95% CI=1.12-1.25; TC vs. TT: OR=1.14, 95% CI=1.06-1.22). There was no correlation found in hospital-based (HB) genetic group yet.
  
  
  CONCLUSIONS
  APOA5 T1131C polymorphism might be significantly associated with susceptibility to CAD.
authors: Department for VIP Patients, The Navy General Hospital of PLA Haidian District, Beijing 100048, China.
authors: Jing
authors: J
authors: Xia
authors: Department of Heart Center, The Navy General Hospital of PLA Haidian District, Beijing 100048, China.
authors: Weiping
authors: W
authors: Cai
authors: Department for VIP Patients, The Navy General Hospital of PLA Haidian District, Beijing 100048, China.
authors: Caosheng
authors: C
authors: Peng
keywords: Apolipoprotein A5; coronary artery disease; polymorphism