title: Changes of Cardiac Function During Ultradistance Trail Running.
abstract: Previous studies have noted reversible cardiac dysfunction during marathon races, but few data are available concerning ultradistance trail running. The aim of this study was to assess echocardiographic parameters during ultradistance trail running. We performed an observational study in 66 participants to the 80-km Ecotrail of Paris Ile de France. All subjects had echocardiographic examinations before the race and on arrival, and 28 of them underwent serial echocardiographic examinations during the race (21 and 53 km). A single experienced physician performed all echocardiographic examinations, and the same protocol was always used (conventional 2-dimensional and Doppler left ventricular parameters and longitudinal strain). All echocardiographic parameters of left ventricular (LV) systolic function were significantly decreased on arrival (p ≤0.002). A significant reduction of LV systolic function was observed in 48% of study subjects on arrival. No significant modification was observed at 21 or at 53 km, and only global longitudinal strain was significantly decreased (p = 0.0008). At arrival, mitral E/A ratio and average mitral tissue Doppler imaging e' wave were significantly decreased (p = 0.0001 and p = 0.0004, respectively), but these changes were observed from 21 km. In conclusion, ultradistance trail running can lead to abnormalities of LV systolic and diastolic functions in amateur runners. Diastolic dysfunction arises earlier than systolic dysfunction. Left ventricular systolic dysfunction occurred in 48% of the study subjects and was detected early by assessment of longitudinal strain.
authors: Intensive Care Unit, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Université de Versailles Saint-Quentin, Boulogne, France.
authors: Romain
authors: R
authors: Jouffroy
authors: Intensive Care Unit, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Université de Versailles Saint-Quentin, Boulogne, France.
authors: Vincent
authors: V
authors: Caille
authors: Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Centre de Référence des Maladies Cardiaques Héréditaires, Université de Versailles Saint-Quentin, Boulogne, France.
authors: Stéphane
authors: S
authors: Perrot
authors: Intensive Care Unit, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Université de Versailles Saint-Quentin, Boulogne, France.
authors: Antoine
authors: A
authors: Vieillard-Baron
authors: Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Centre de Référence des Maladies Cardiaques Héréditaires, Université de Versailles Saint-Quentin, Boulogne, France; INSERM U-1018, Centre de recherche en épidémiologie et santé des populations (CESP), Team 5 (EpReC, Renal and Cardiovascular Epidemiology), Université de Versailles Saint-Quentin, Villejuif, France.
authors: Olivier
authors: O
authors: Dubourg
authors: Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Centre de Référence des Maladies Cardiaques Héréditaires, Université de Versailles Saint-Quentin, Boulogne, France; INSERM U-1018, Centre de recherche en épidémiologie et santé des populations (CESP), Team 5 (EpReC, Renal and Cardiovascular Epidemiology), Université de Versailles Saint-Quentin, Villejuif, France. Electronic address: nicolas.mansencal@apr.aphp.fr.
authors: Nicolas
authors: N
authors: Mansencal
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology; D012420:Running / Q000502:physiology*; D013318:Stroke Volume / Q000502:physiology*; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult