title: Preparation of 1-Tosyloxy-4-Substituted-2-butenes Using Ag(I) Salts.
abstract: Thetrans-fluoro-2-butenyl group has been previously utilized as anN-substituent on several nortropanes for imaging the dopamine transporter with positron emission tomography. We report here a simplified and shorter synthesis oftrans-1-tosyloxy-4-substituted-2-butenes using Ag(I) salts. This methodology was also applied to the synthesis of thecis-isomers. Furthermore, these procedures allow for the recovery of the majority of the Ag(I) ions.
authors: Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.
authors: Jeffrey S
authors: JS
authors: Stehouwer
authors: Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.
authors: Mark M
authors: MM
authors: Goodman
keywords: Fluorine-18; Fluorobutenyl-tosylate; N-fluorobutenyl-nortropane; Positron emission tomography