title: Replication analysis of genetic variants on 17q11.2 and 9p21.2 with sporadic amyotrophic lateral sclerosis and Parkinson's disease in a Chinese population.
abstract: We performed a replication study of the 2 genetic variants, rs34517613 on 17q11.2 and rs3849942 on 9p21.2 in patients with sporadic amyotrophic lateral sclerosis (ALS) and Parkinson's disease in a Chinese population. These 2 variants are identified to be associated with increased risk of ALS in European-descended populations by genome-wide association studies. Both rs34517613 and rs3849942 showed no evidence of association in Chinese. These loci are not risk factors for sporadic ALS and Parkinson's disease in the western Han Chinese population.
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Xueping
authors: X
authors: Chen
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Yongping
authors: Y
authors: Chen
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Xiaoyan
authors: X
authors: Guo
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Bei
authors: B
authors: Cao
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Qianqian
authors: Q
authors: Wei
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Ruwei
authors: R
authors: Ou
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Bi
authors: B
authors: Zhao
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Wei
authors: W
authors: Song
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Ying
authors: Y
authors: Wu
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: hfshang2002@163.com.
authors: Hui-Fang
authors: HF
authors: Shang
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D044466:Asian People; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D056426:Genetic Loci / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics*; D012306:Risk
keywords: 17q11.2; 9p21.2; Parkinson's disease; Sporadic amyotrophic lateral sclerosis; rs34517613; rs3849942