title: [A Newly Diagnosed Case of Multiple Myeloma in Which Lenalidomide Was Continued after Surgery for a Pancreatic Neuroendocrine Tumor That Developed during Lenalidomide Maintenance Therapy].
abstract: A 75-year-old woman was diagnosed with symptomatic IgG-l multiple myeloma (good-prognosis group) in December 2010. A stringent complete response (sCR) was achieved by using induction therapy with bortezomib (BOR, Velcade®)+ dexamethasone (DEX)(VD) and consolidation therapy with BOR+lenalidomide (LEN, Revlimid®)+DEX(VRD). Although maintenance therapy with Revlimid®+DEX(Rd) was initiated, a pancreatic neuroendocrine tumor was detected in April 2013. Therefore, LEN was discontinued and distal pancreatectomy was performed in September 2013. Because discontinuation of LEN was followed by exacerbation of myeloma, LEN was resumed with the consent of the patient; however, she became resistant to the treatment. The course of this case suggests that some patients must continue to receive LEN even if a sCR is achieved.
authors: Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital.
authors: Hiroyuki
authors: H
authors: Kuroda
authors: Masahiro
authors: M
authors: Yoshida
authors: Makoto
authors: M
authors: Usami
authors: Saori
authors: S
authors: Shimoyama
authors: Hiroki
authors: H
authors: Sakamoto
authors: Michiko
authors: M
authors: Yamada
authors: Shigeyuki
authors: S
authors: Fujii
authors: Masahiro
authors: M
authors: Maeda
authors: Miri
authors: M
authors: Fujita
authors: Yusuke
authors: Y
authors: Kanari
authors: Tsutomu
authors: T
authors: Sato
authors: Junji
authors: J
authors: Kato
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D000077269:Lenalidomide; D009101:Multiple Myeloma / Q000188:drug therapy*; D016609:Neoplasms, Second Primary / Q000188:drug therapy* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D013792:Thalidomide; D000077269:Lenalidomide