title: Nutrition, Nitrogen Requirements, Exercise and Chemotherapy-Induced Toxicity in Cancer Patients. A puzzle of Contrasting Truths?
abstract: Amino acids can modulate cell metabolism and control cell fate by regulating cell survival and cell death. The molecular mechanisms involved are mediated by the mTOR complexes mTORC1 and mTORC2 activity. These complexes are finely regulated and the continuous advancement of the knowledge on their composition and function is revealing that their balance may represent the condition that determines the cell fate. This is important for normal healthy cells but it is becoming clear, and it is even more important, that the balance of the mTORCs activity may also condition the cell fate of cancer cells. Here, we discuss the evidences supporting the amino acids supplementation as a cancer fighting weapon and a possible strategy to counteract the myocyte toxicity associated with chemotherapy, possibly by tipping the balance of mTORCs activity.
authors: Vincenzo
authors: V
authors: Flati
authors: Giovanni
authors: G
authors: Corsetti
authors: Evasio
authors: E
authors: Pasini
authors: Anna
authors: A
authors: Rufo
authors: Claudia
authors: C
authors: Romano
authors: Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, via San Barnaba 8, 20122 Milano, Italy. fsdioguardi@gmail.com.
authors: Francesco Saverio
authors: FS
authors: Dioguardi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D015444:Exercise; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D009751:Nutritional Requirements
chemical_list: D009584:Nitrogen