title: Uric acid and coronary artery disease: An elusive link deserving further attention.
abstract: Uric acid is the final product of purine metabolism. Classically it is recognized as the cause of gouty arthritis and kidney stones. Western civilization has increased serum levels of uric acid which is no longer considered a benign plasma solute. It has been postulated and recently demonstrated that it can penetrate cell membrane and exerts damaging intracellular actions such as oxidation and inflammation. These observations have stimulated several epidemiological researches suggesting that hyperuricemia is linked or even provokes hypertension and coronary artery disease. In this review we summarize the current evidences regarding uric acid which contribute in the pathophysiology of coronary artery disease.
authors: Department of Cardiology, University Hospital of Ferrara, Italy.
authors: Simone
authors: S
authors: Biscaglia
authors: Department of Cardiology, University Hospital of Ferrara, Italy; LTTA Centre, University Hospital of Ferrara, Italy.
authors: Claudio
authors: C
authors: Ceconi
authors: Department of Cardiology, University Hospital of Ferrara, Italy.
authors: Michele
authors: M
authors: Malagù
authors: Department of Cardiology, University Hospital of Ferrara, Italy.
authors: Rita
authors: R
authors: Pavasini
authors: Department of Cardiology, University Hospital of Ferrara, Italy; LTTA Centre, University Hospital of Ferrara, Italy; Maria Cecilia Hospital, GVM Care & Research, E.S.: Health Science Foundation, Cotignola, Italy. Electronic address: fri@unife.it.
authors: Roberto
authors: R
authors: Ferrari
mesh_terms: D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000150:complications; D033461:Hyperuricemia / Q000097:blood; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: CAD; Reactive oxygen species; Uric acid