title: Pd-Catalyzed Stereoselective Carboperfluoroalkylation of Alkynes.
abstract: A Pd-catalyzed three component reaction involving terminal alkynes, boronic acids, and perfluoroalkyl iodides is presented here. Trisubstituted perfluoroalkenes can be obtained in a highly regio- and stereocontrolled manner by the simultaneous addition of both aryl and CnFm groups across the triple bond in a radical-mediated process. The reaction is operationally simple offering a broad scope and functional group tolerance.
authors: Department of Chemistry, University of Zurich , Winterthurerstrasse 190, CH 8057 Zurich, Switzerland.
authors: Zhaodong
authors: Z
authors: Li
authors: Department of Chemistry, University of Zurich , Winterthurerstrasse 190, CH 8057 Zurich, Switzerland.
authors: Andrés
authors: A
authors: García-Domínguez
authors: Department of Chemistry, University of Zurich , Winterthurerstrasse 190, CH 8057 Zurich, Switzerland.
authors: Cristina
authors: C
authors: Nevado
mesh_terms: D000478:Alkylation; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D005466:Fluorocarbons / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D005466:Fluorocarbons; D010165:Palladium