title: The association study on renalase polymorphism and hypertension: a meta-analysis.
abstract: Hypertension is considered a multi-factorial disease since its development is affected by both genetic and environmental factors. Intensive efforts have been focused on identifying gene(s) related to hypertension. Renalase is a recently discovered protein that expressed in kidney, heart, liver, and brain that metabolizes catecholamines, regulation of blood pressure in humans and animals. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. But the reported results are not always consistent. In this meta-analysis, we examined the association between (Glu37Asp) polymorphism (rs2296545) in renalase gene and risk of hypertension. Through a systematic literature search for publications between 2007 and 2014, we summarized the data from 4 studies on polymorphism (rs2296545) in renalase gene and risk of hypertension. We did not find any association of rs2296545 with risk of hypertension in dominant model (OR=0.64; 95% CI: 0.41-1.00), recessive model (OR=1.29, 95% CI: 0.95-1.75), co-dominant model (OR=1.38, 95% CI: 0.92-2.08), and allelic model (OR=1.19; 95% CI: 0.96-1.47). The results of the present study indicated that the renalase genetic polymorphism was not associated with risk of hypertension.
authors: Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing Institute of Cardiology Chongqing 400042, P.R. China.
authors: Wei-Bin
authors: WB
authors: Shi
authors: Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing Institute of Cardiology Chongqing 400042, P.R. China.
authors: Hong-Yong
authors: HY
authors: Wang
keywords: Renalase gene; hypertension; meta-analysis; polymorphism