title: A Hitchhiker's Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System.
abstract: The classification of mononuclear phagocytes as either dendritic cells or macrophages has been mainly based on morphology, the expression of surface markers, and assumed functional specialization. We have recently proposed a novel classification system of mononuclear phagocytes based on their ontogeny. Here, we discuss the practical application of such a classification system through a number of prototypical examples we have encountered while hitchhiking from one subset to another, across species and between steady-state and inflammatory settings. Finally, we discuss the advantages and drawbacks of such a classification system and propose a number of improvements to move from theoretical concepts to concrete guidelines.
authors: Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent University , Ghent , Belgium ; Department of Respiratory Medicine, University Hospital Ghent , Ghent , Belgium.
authors: Martin
authors: M
authors: Guilliams
authors: Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent University , Ghent , Belgium ; Department of Respiratory Medicine, University Hospital Ghent , Ghent , Belgium.
authors: Lianne
authors: L
authors: van de Laar
keywords: classification; dendritic cells; macrophages; monocytes; nomenclature