title: Synthesis of Uniform, Monodisperse, Sophorolipid Twisted Ribbons.
abstract: Control over size monodispersity in chiral self-assembled systems is important for potential applications like templating, tissue engineering or enantioselective chromatography, just to cite a few examples. In this context, it was reported that the saturated form of sophorolipids (SL), a bioderived glycolipid, are able to form self-assembled twisted ribbons in water at neutral pH. Here, we show the possibility to control their size dispersion, generally between 10 and 40 nm after synthesis to a value of 13.5±1.5 nm, by a simple dialysis step eliminating the excess of NaCl. We use transmission electron microscopy under cryogenic conditions (cryo-TEM) combined with small angle neutron scattering (SANS) to characterize the ribbon dispersion both visually and statistically. Two negative controls show the importance of salt in the aggregation process of the ribbons.
authors: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, UMR 7574, Chimie de la Matière Condensée de Paris, F-75005, Paris, France.
authors: Anne-Sophie
authors: AS
authors: Cuvier
authors: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, UMR 7574, Chimie de la Matière Condensée de Paris, F-75005, Paris, France.
authors: Florence
authors: F
authors: Babonneau
authors: SynBioC Research Group, Departement of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000, Gent, Belgium.
authors: Jan
authors: J
authors: Berton
authors: SynBioC Research Group, Departement of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000, Gent, Belgium.
authors: Christian V
authors: CV
authors: Stevens
authors: Laboratoire Léon Brillouin, LLB, CEA Saclay, F-91191, Gif-sur-Yvette Cedex, France.
authors: Giulia C
authors: GC
authors: Fadda
authors: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, UMR 7574, Chimie de la Matière Condensée de Paris, F-75005, Paris, France.
authors: Isabelle
authors: I
authors: Genois
authors: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, UMR 7574, Chimie de la Matière Condensée de Paris, F-75005, Paris, France.
authors: Patrick
authors: P
authors: Le Griel
authors: Institut Pasteur, UMR3528, 28 Rue du Docteur Roux, F-75015, Paris, France.
authors: Gérard
authors: G
authors: Péhau-Arnaudet
authors: Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, UMR 7574, Chimie de la Matière Condensée de Paris, F-75005, Paris, France. niki.baccile@upmc.fr.
authors: Niki
authors: N
authors: Baccile
mesh_terms: D002942:Circular Dichroism; D006017:Glycolipids / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D033363:Neutron Diffraction; D053838:Scattering, Small Angle; D012965:Sodium Chloride / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006017:Glycolipids; D012965:Sodium Chloride
keywords: acidic sophorolipids; colloids; saturated sophorolipids; self-assembly; twisted ribbons