title: International Veterinary Epilepsy Task Force's current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs.
abstract: Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in particular our knowledge of those breeds studied. However, these studies also frequently revealed differences between the investigated breeds with respect to clinical features, inheritance and prevalence rates. Awareness and observation of breed-specific differences is important for successful management of the dog with epilepsy in everyday clinical practice and furthermore may promote canine epilepsy research. The following manuscript reviews the evidence available for breeds which have been identified as being predisposed to idiopathic epilepsy with a proven or suspected genetic background, and highlights different breed specific clinical features (e.g. age at onset, sex, seizure type), treatment response, prevalence rates and proposed inheritance reported in the literature. In addition, certain breed-specific diseases that may act as potential differentials for idiopathic epilepsy are highlighted.
authors: Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Veterinärstr. 13, 80539, Munich, Germany. v.huelsmeyer@medizinische-kleintierklinik.de.
authors: Velia-Isabel
authors: VI
authors: Hülsmeyer
authors: Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Veterinärstr. 13, 80539, Munich, Germany. andreafischer@lmu.de.
authors: Andrea
authors: A
authors: Fischer
authors: Department of Clinical Sciences of Companion Animals, Utrecht University, Yalelaan 108, 3583 CM, Utrecht, The Netherlands. P.J.J.Mandigers@uu.nl.
authors: Paul J J
authors: PJ
authors: Mandigers
authors: Animal Health Trust, Lanwades Park, Kentford, Newmarket, CB8 7UU, Suffolk, United Kingdom. luisa.derisio@aht.org.uk.
authors: Luisa
authors: L
authors: DeRisio
authors: Department of Veterinary and Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark. mbe@sund.ku.dk.
authors: Mette
authors: M
authors: Berendt
authors: Fitzpatrick Referrals, Halfway Lane, Eashing, Godalming, GU7 2QQ, Surrey, United Kingdom. ClareR@fitzpatrickreferrals.co.uk.|School of Veterinary Medicine, Faculty of Health & Medical Sciences, University of Surrey, Guildford, GU2 7TE, Surrey, United Kingdom. ClareR@fitzpatrickreferrals.co.uk.
authors: Clare
authors: C
authors: Rusbridge
authors: Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium. sofie.bhatti@ugent.be.
authors: Sofie F M
authors: SF
authors: Bhatti
authors: Clinical Unit of Internal Medicine Small Animals, University of Veterinary Medicine, Veterinärplatz 1, 1210, Vienna, Austria. akos.pakozdy@vetmeduni.ac.at.
authors: Akos
authors: A
authors: Pakozdy
authors: University of Minnesota College of Veterinary Medicine, D426 Veterinary Medical Center, 1352 Boyd Avenue, St. Paul, MN, 55108, USA. patte037@umn.edu.
authors: Edward E
authors: EE
authors: Patterson
authors: College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA, 30602, USA. srplatt@uga.edu.
authors: Simon
authors: S
authors: Platt
authors: Department of Clinical Science and Services, Royal Veterinary College, Hatfield, AL9 7TA, Hertfordshire, UK. rpacker@rvc.ac.uk.
authors: Rowena M A
authors: RM
authors: Packer
authors: Department of Clinical Science and Services, Royal Veterinary College, Hatfield, AL9 7TA, Hertfordshire, UK. hvolk@rvc.ac.uk.
authors: Holger A
authors: HA
authors: Volk
mesh_terms: D000375:Aging; D000818:Animals; D001947:Breeding; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D004827:Epilepsy / Q000235:genetics / Q000662:veterinary*; D005260:Female; D020022:Genetic Predisposition to Disease; D038622:Internationality; D008297:Male; D012737:Sex Factors; D014730:Veterinary Medicine / Q000458:organization & administration*