title: Evaluation of the relationship between T663A polymorphism in the alpha-epithelial sodium channel gene and essential hypertension.
abstract: OBJECTIVE
  To evaluate the relationship between alpha epithelial sodium channel (alpha-ENaC) T663A polymorphism and the risk of essential hypertension.
  
  
  METHODS
  This meta-analysis was conducted between November 2014 and February 2015 in Shanghai Medical Instrumentation College, Shanghai, China. We collected all published available case-control data (N=12) identified through PubMed, Web of Science, Scopus, and Chinese National Knowledge Infrastructure (CNKI) up to December 2014. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using the fixed- or random-effect model.
  
  
  RESULTS
  Although subgroup analysis showed that alpha-ENaC T663A polymorphism was associated with essential hypertension in North American individuals (OR=1.55, 95% CI=1.22-1.98, p=0.0003), our meta-analysis results did not confirm such association overall (OR=1.03, 95% CI=0.92-1.15, p=0.62). The lack of association was further confirmed by the non-superiority test (p less than 0.0001).
  
  
  CONCLUSIONS
  Alpha-ENaC T663A polymorphism might not be a risk factor for essential hypertension.
authors: School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China. E-mail. chaosyw@126.com.
authors: Wenchao
authors: W
authors: Yang
authors: Zhenmin
authors: Z
authors: Zhu
authors: Jin
authors: J
authors: Wang
authors: Wei
authors: W
authors: Ye
authors: Yong
authors: Y
authors: Ding
mesh_terms: D053503:Epithelial Sodium Channels / Q000235:genetics*; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D053503:Epithelial Sodium Channels; C507045:SCNN1A protein, human