title: Autophagy in bone: Self-eating to stay in balance.
abstract: Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight the autophagy role in the different bone cell types, i.e., osteoblasts, osteoclasts and osteocytes. We also discuss the effects of autophagy modulators in bone physiology and of bone anabolic compounds in autophagy. Finally, we analyzed studies regarding bone cell autophagy-deficient mouse models to obtain a more general view on how autophagy modulates bone physiology and pathophysiology, particularly during aging.
authors: UMR E-4320 TIRO-MATOs CEA/iBEB, Université Nice Sophia Antipolis, Faculté de Médecine Nice, France. Electronic address: pierrefi@unice.fr.
authors: Valérie
authors: V
authors: Pierrefite-Carle
authors: UMR E-4320 TIRO-MATOs CEA/iBEB, Université Nice Sophia Antipolis, Faculté de Médecine Nice, France.
authors: Sabine
authors: S
authors: Santucci-Darmanin
authors: UMR E-4320 TIRO-MATOs CEA/iBEB, Université Nice Sophia Antipolis, Faculté de Médecine Nice, France; Service de Rhumatologie, CHU de Nice, Nice, France.
authors: Véronique
authors: V
authors: Breuil
authors: UMR E-4320 TIRO-MATOs CEA/iBEB, Université Nice Sophia Antipolis, Faculté de Médecine Nice, France; Service de Chirurgie Réparatrice et de la main, CHU de Nice, Nice, France.
authors: Olivier
authors: O
authors: Camuzard
authors: UMR E-4320 TIRO-MATOs CEA/iBEB, Université Nice Sophia Antipolis, Faculté de Médecine Nice, France.
authors: Georges F
authors: GF
authors: Carle
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice
keywords: Autophagy; Bone; Osteoporosis