title: [Optogenetics brings hidden neural mechanisms into the light and could become a future therapy].
abstract: Optogenetics is an emergent technology that combines light-sensitive proteins derived from algae, so-called opsins, with genetics. Viral vectors encoding opsins are injected into selective brain regions whereby specific cell populations can be controlled with high precision light pulses delivered via implanted optical fibres. This review focuses on explaining basic principles of optogenetics and describes important insights into neuropsychiatric mechanisms provided by the technology.
authors: Tobias Melton
authors: TM
authors: Axelsen
authors: Charlotte Amalie Emdal
authors: CA
authors: Navntoft
authors: Søren Hofman
authors: SH
authors: Christiansen
authors: Jakob Kisbye
authors: JK
authors: Dreyer
authors: Jakob Balslev
authors: JB
authors: Sørensen
authors: Ulrik
authors: U
authors: Gether
authors: Laboratorium for Neural Plasticitet, Institut for Neurovidenskab og Farmakologi, Københavns Universitet, Symbion, Fruebjergvej 3, 2100 København Ø. woldbye@sund.ku.dk.
authors: David Paul Drucker
authors: DP
authors: Woldbye
mesh_terms: D006801:Humans; D001523:Mental Disorders / Q000628:therapy; D009422:Nervous System Diseases / Q000628:therapy; D009474:Neurons / Q000378:metabolism; D055355:Opsins / Q000378:metabolism; D062308:Optogenetics; D015222:Sodium Channels / Q000378:metabolism
chemical_list: D055355:Opsins; D015222:Sodium Channels