title: Protocatechuic acid protects brain mitochondrial function in streptozotocin-induced diabetic rats.
abstract: Brain mitochondrial dysfunction has been demonstrated in diabetic animals with neurodegeneration. Protocatechuic acid (PCA), a major metabolite of anthocyanin, has been shown to exert glycemic control and oxidative stress reduction in the heart. However, its effects on oxidative stress and mitochondrial function in the brain under diabetic condition have never been investigated. We found that PCA exerted glycemic control, attenuates brain mitochondrial dysfunction, and contributes to the prevention of brain oxidative stress in diabetic rats.
authors: a Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.|b Veterinary Technology Program, Faculty of Technology, Udon Thani Rajabhat University, Udon Thani 41000 Thailand.
authors: Yoswaris
authors: Y
authors: Semaming
authors: a Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.|c Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
authors: Jirapas
authors: J
authors: Sripetchwandee
authors: a Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.|c Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
authors: Piangkwan
authors: P
authors: Sa-Nguanmoo
authors: a Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.|c Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
authors: Hiranya
authors: H
authors: Pintana
authors: a Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.|d Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Patchareewan
authors: P
authors: Pannangpetch
authors: a Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.|c Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
authors: Nipon
authors: N
authors: Chattipakorn
authors: a Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.|e Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
authors: Siriporn C
authors: SC
authors: Chattipakorn
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental; D004195:Disease Models, Animal; D062385:Hydroxybenzoates / Q000494:pharmacology*; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016588:Anticarcinogenic Agents; D062385:Hydroxybenzoates; C009091:protocatechuic acid
keywords: acide protocatéchique; brain mitochondria protocatechuic acid; diabète sucré insulinodépendant; insulin-dependent diabetes mellitus; mitochondrie cérébrale; oxidative stress; stress oxydatif