title: Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly.
abstract: Postoperative cognitive dysfunction (POCD) is a common complication associated with significant morbidity and mortality in elderly patients. There is much interest in and controversy about POCD, reflected partly in the increasing number of articles published on POCD recently. Recent work suggests surgery may also be associated with cognitive improvement in some patients, termed postoperative cognitive improvement (POCI). As the number of surgeries performed worldwide approaches 250 million per year, optimizing postoperative cognitive function and preventing/treating POCD are major public health issues. In this article, we review the literature on POCD and POCI, and discuss current research challenges in this area.
authors: Department of Anesthesiology, Duke University Medical Center, Duke South, Orange Zone, Room 4317, Durham, NC 27710, USA. Electronic address: miles.berger@duke.edu.
authors: Miles
authors: M
authors: Berger
authors: Department of Anesthesiology, Duke University Medical Center, Duke South, Orange Zone, Room 4317, Durham, NC 27710, USA.
authors: Jacob W
authors: JW
authors: Nadler
authors: Department of Anesthesiology, Duke University Medical Center, Duke South, Orange Zone, Room 4317, Durham, NC 27710, USA.
authors: Jeffrey
authors: J
authors: Browndyke
authors: Department of Anesthesiology, Duke University Medical Center, Duke South, Orange Zone, Room 4317, Durham, NC 27710, USA.
authors: Niccolo
authors: N
authors: Terrando
authors: Department of Anesthesiology, Duke University Medical Center, Duke South, Orange Zone, Room 4317, Durham, NC 27710, USA.
authors: Vikram
authors: V
authors: Ponnusamy
authors: Department of Anesthesiology, Duke University Medical Center, Duke South, Orange Zone, Room 4317, Durham, NC 27710, USA.
authors: Harvey Jay
authors: HJ
authors: Cohen
authors: Department of Anesthesiology, Duke University Medical Center, Duke South, Orange Zone, Room 4317, Durham, NC 27710, USA.
authors: Heather E
authors: HE
authors: Whitson
authors: Department of Anesthesiology, Duke University Medical Center, Duke South, Orange Zone, Room 4317, Durham, NC 27710, USA.
authors: Joseph P
authors: JP
authors: Mathew
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000209:etiology* / Q000523:psychology; D003693:Delirium / Q000209:etiology / Q000523:psychology; D006801:Humans; D011183:Postoperative Complications / Q000453:epidemiology* / Q000523:psychology; D011788:Quality of Life; D055500:Resilience, Psychological
keywords: Anesthesia; Elderly; Post-operative cognitive decline; Post-operative cognitive dysfunction; Post-operative cognitive improvement; Surgery