title: Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women.
abstract: OBJECTIVE
  The aim of this study was to investigate whether polymorphisms in the tissue inhibitor of metalloproteinase 3 gene (TIMP3) are associated with the risk of preeclampsia (PE) in Han Chinese women.
  
  
  METHODS
  Nine single TIMP3 tag-single nucleotide polymorphisms were selected by Haploview and genotyped using the Sequenom method in 181 preeclamptic and 203 healthy pregnant women from eastern China.
  
  
  RESULTS
  The allele frequencies of the tag-single nucleotide polymorphisms were not significantly different between groups (P > 0.05). However, the genotype distribution of rs135025 was shown to differ between the multigravidity PE subgroup (>3) and controls under additive (P = 0.018) and recessive models (P = 0.008), while the genotype distribution of rs80272 differed significantly between the severe PE subgroup and controls under additive (P = 0.014) and dominant models (P = 0.041). Moreover, the H2 haplotype (A-C-G-T-A-A-G-C-G) was found to be associated with the risk of PE (P = 0.035).
  
  
  CONCLUSIONS
  Genotypes of rs135025 and rs80272 in TIMP3 may therefore influence susceptibility to PE, and pregnant women carrying the H2 haplotype might be more prone to developing PE.
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
authors: Changlong
authors: C
authors: Guo
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
authors: Xiaofang
authors: X
authors: Cao
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
authors: Qidi
authors: Q
authors: Wang
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
authors: Guangyu
authors: G
authors: Wang
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
authors: Lisha
authors: L
authors: An
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
authors: Meng
authors: M
authors: Du
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
authors: Yue
authors: Y
authors: Qiu
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China.
authors: Ying
authors: Y
authors: Yang
authors: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
authors: Hui
authors: H
authors: Li
authors: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
authors: Yuting
authors: Y
authors: Wang
authors: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
authors: Shuo
authors: S
authors: Wang
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China. xingyuwang@yahoo.com.
authors: Xingyu
authors: X
authors: Wang
authors: National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China. xumagroup@163.com.|Graduate School of Peking Union Medical College, Beijing, China. xumagroup@163.com.|World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China. xumagroup@163.com.
authors: Xu
authors: X
authors: Ma
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008423:Maternal Age; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D019717:Tissue Inhibitor of Metalloproteinase-3 / Q000235:genetics*
chemical_list: C088390:TIMP3 protein, human; D019717:Tissue Inhibitor of Metalloproteinase-3
keywords: Genetic polymorphism; Haplotype analysis; Preeclampsia; Tissue inhibitors of matrix metalloproteinases 3