title: The correlation between the metabolic tumor volume and hematological parameters in patients with esophageal cancer.
abstract: BACKGROUND
  The aim of this study is to evaluate the correlation of the serum neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV), with the standardized uptake value (SUVmax), and metabolic tumor volume (MTV) in F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patient with esophageal squamous cell cancer at baseline.
  
  
  METHODS
  PET/CTs were performed in 52 patients with esophageal squamous cell cancer, making up the patient group. An additional 52 patients who underwent endoscopy due to dyspepsia with normal esophagus (as a control group) were included in the study to compare the hematological parameters between the patient groups.
  
  
  RESULTS
  The median age was 60.0 ± 12.8 years (range 39-84 years) for the patients with esophageal cancer, and 56.9 ± 12.3 years for the control group. Statistical differences were found in terms of the neutrophils, lymphocytes, NLR, PLT, PLR, and MPV between the patients with esophageal cancer and the control group. In the correlation analysis, only the NLR was correlated with the MTV for all of the patients (p = 0.013, r = 0.344). The SUVmax was not correlated with these hematological parameters.
  
  
  CONCLUSIONS
  At baseline neutrophil-to-lymphocyte ratio is associated with the metabolic tumor volume, which was assessed using the PET/CT in patients with esophageal squamous cell cancer. The SUVmax values were not related to these parameters.
authors: Department of Nuclear Medicine, School of Medicine, Yüzüncü Yıl University, Van, Turkey. surucuerdem@hotmail.com.
authors: Erdem
authors: E
authors: Sürücü
authors: Department of Nuclear Medicine, School of Medicine, Yüzüncü Yıl University, Van, Turkey.
authors: Yusuf
authors: Y
authors: Demir
authors: Department of Nuclear Medicine, School of Medicine, Pamukkale University, Denizli, Turkey.
authors: Tarık
authors: T
authors: Şengöz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000097:blood / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D019788:Fluorodeoxyglucose F18; D006403:Hematologic Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Esophagus squamous cell cancer; F-18 FDG PET-CT; MTV; NLR; SUV