title: Association between angiotensinogen M235T polymorphism and hypertrophic cardiomyopathy.
abstract: BACKGROUND
  To investigate the relationship between angiotensinogen (AGT) gene M235T polymorphism and hypertrophic cardiomyopathy (HCM) to explore the potential role of the AGT polymorphism in HCM.
  
  
  METHODS
  PubMed, Embase, OVID, Cochrane library, CNKI, Wan Fang Database were searched to identify the studies involving AGT M235T polymorphism and HCM. Two authors performed independent literature review and study quality assessment using the Newcastle-Ottawa Scale (NOS) checklist. A random-effects model was used to calculate the overall combined risk estimates.
  
  
  RESULTS
  Nine studies involving 887 cases and 1407 controls were included in our meta-analysis. No significant associations were found between AGT M235T polymorphism and HCM (allele model T vs M: OR = 1.17, 95% CI = 0.95-1.45; dominant model TT vs (MM/MT): OR = 1.21, 95% CI = 1.00-1.45; recessive model (TT/MT) vs MM: OR = 1.12, 95% CI = 0.87-1.45; heterozygous comparison MT vs MM: OR = 1.07, 95% CI = 0.82-1.41; homozygous comparison TT vs MM OR = 1.19, 95% CI = 0.88-1.61. In subgroup analysis, the significant difference of association between AGT M235T polymorphism and HCM existed in Asian and sporadic hypertrophic cardiomyopathy (SHCM), but no significant difference was found in Europeans and familial hypertrophic cardiomyopathy (FHCM).
  
  
  CONCLUSIONS
  There is no association between AGT M235T polymorphism and HCM in general populations, but such a relationship exists in Asians and SHCM.
authors: Department of Cardiology, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
authors: Jia-Lu
authors: JL
authors: Yao
authors: Department of Cardiology, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
authors: Si-Jia
authors: SJ
authors: Sun
authors: Department of Cardiology, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
authors: Ya-Feng
authors: YF
authors: Zhou
authors: Department of Cardiology, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
authors: Lang-Biao
authors: LB
authors: Xu
authors: Department of Cardiology, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
authors: Xiang-Jun
authors: XJ
authors: Yang
authors: Department of Cardiology, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
authors: Xiao-Dong
authors: XD
authors: Qian
keywords: Hypertrophic cardiomyopathy; angiotensinogen; gene polymorphism; meta-analysis