title: Prognostic Value of Preradiotherapy (18)F-FDG PET/CT Volumetrics in Limited-Stage Small-Cell Lung Cancer.
abstract: Whether (18)F-fludeoxyglucose positron emission tomography (PET)/computed tomography (CT) metrics predict outcome in limited-stage (LS) small-cell lung cancer (SCLC) has not been well established; most previous reports have only analyzed maximal standardized uptake values (SUVmax). We investigated multiple pretreatment PET metrics, including SUVmax, mean SUV (SUVmean), total lesion glycolysis, and metabolic tumor volume (MTV) in LS-SCLC patients undergoing chemoradiotherapy (CRT) and correlated them with survival and disease control outcomes.
  
  
  
  All patients received platinum-based chemotherapy and a median radiation dose of 45 Gy. Kaplan-Meier and competing-risks analyses were performed to assess the prognostic value of PET metrics with respect to overall survival (OS), distant failure (DF), disease-free survival (DFS), and locoregional failure (LRF). Univariate and multivariate analyses were performed to account for the effect of other clinical factors on outcomes.
  
  
  
  A total of 120 patients with LS-SCLC had analyzable pre-CRT PET/CTs. The median follow up was 34 months. Median OS was 26.9 months. OS was 53.2% at 2 years and 33.1% at 5 years. SUVmax, SUVmean, MTV, and total lesion glycolysis of the primary tumor were not significantly associated with OS, LRF, and DFS on univariate analysis. MTV was significantly associated with DF (P = .024) on univariate but not multivariate analysis.
  
  
  
  This is the largest reported series to date evaluating the prognostic value of baseline PET metrics in LS-SCLC. Neither SUVmax nor other analyzed PET metrics demonstrated significant correlation with OS or LRF. MTV was correlated with DF and DFS, but this association was no longer significant after adjustment for other clinical factors. This analysis suggests that pretreatment PET scans, even with the use of advanced metrics, do not have independent prognostic value for outcomes in LS-SCLC patients after CRT.
authors: Department of Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Leonard T
authors: LT
authors: Ong
authors: Department of Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Mark
authors: M
authors: Dunphy
authors: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Amanda
authors: A
authors: Foster
authors: Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Kaitlin M
authors: KM
authors: Woo
authors: Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Zhigang
authors: Z
authors: Zhang
authors: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Carmen A
authors: CA
authors: Perez
authors: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Catherine M
authors: CM
authors: Pietanza
authors: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Kenneth E
authors: KE
authors: Rosenzweig
authors: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Daphna Y
authors: DY
authors: Gelblum
authors: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Andreas
authors: A
authors: Rimner
authors: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: wua@mskcc.org.
authors: Abraham J
authors: AJ
authors: Wu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis; D047368:Tumor Burden
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Advanced PET metrics; Chemoradiotherapy; Lung cancer; MTV; Overall survival