title: Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation.
abstract: By grafting multiple DNA strands onto one terminus of a polyester chain, a DNA-brush block copolymer that can assemble into micelle structure is constructed. These micelle spherical nucleic acids have a density of nucleic acids that is substantively higher than linear DNA block copolymer structures, which makes them effective cellular transfection and intracellular gene regulation agents.
authors: Department of Chemistry, International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.
authors: Chuan
authors: C
authors: Zhang
authors: Department of Chemistry, International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.
authors: Liangliang
authors: L
authors: Hao
authors: Department of Chemistry, International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.
authors: Colin M
authors: CM
authors: Calabrese
authors: Department of Materials Science and Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.
authors: Yu
authors: Y
authors: Zhou
authors: Department of Chemistry, International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.
authors: Chung Hang J
authors: CH
authors: Choi
authors: Department of Chemistry, International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.
authors: Hang
authors: H
authors: Xing
authors: Department of Chemistry, International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.|Department of Materials Science and Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.
authors: Chad A
authors: CA
authors: Mirkin
mesh_terms: D004247:DNA / Q000737:chemistry; D008823:Micelles; D009696:Nucleic Acids / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D008823:Micelles; D009696:Nucleic Acids; D011108:Polymers; D011092:Polyethylene Glycols; D004247:DNA
keywords: DNA-brush block copolymers; cellular uptake; gene regulation; micelles; spherical nucleic acids