title: Association Between Testosterone Supplementation Therapy and Thrombotic Events in Elderly Men.
abstract: OBJECTIVE
  To determine the prevalence of thrombotic events and all-cause mortality in men older than 65 years with hypogonadism treated with testosterone therapy (TST).
  
  
  METHODS
  We retrospectively reviewed the charts of 217 hypogonadal men >65 years. We compared men who received TST (n = 153) to hypogonadal men (n = 64) who did not receive TST. We evaluated all-cause mortality, prevalence of myocardial infarction (MI), transient ischemic attack (TIA), cerebrovascular accident (CVA or "stroke"), and deep vein thrombosis/pulmonary embolism (DVT/PE). All events were verified by contacting patients. We excluded men with previous thrombotic events, men previously on androgen deprivation therapy, and men who had used TST before age of 65 years.
  
  
  RESULTS
  Median age and Charlson Comorbidity Index of men on TST (74y; 5.1) was similar to hypogonadal men not on TST (73y, P = .48; 5.3, P = .36). Median follow-up was 3.8 vs 3.5 years (TST vs no TST). No man on TST died, whereas 5 hypogonadal men who did not receive TST died (P = .007). There were 4 thrombotic events (1 MI, 2 CVA/TIA, and 1 PE) in men who received TST and 1 event (CVA/TIA) among men who did not receive TST (P = .8). All events (1 death, 6-month follow-up) occurred at least after 2 years of follow-up.
  
  
  CONCLUSIONS
  There was increased all-cause mortality in hypogonadal men not treated with testosterone compared to men who received TST. There was no difference in prevalence of MI, TIA/CVA, or PE between patients treated with testosterone and hypogonadal men not treated with testosterone.
authors: Department of Urology, Baylor College of Medicine, Houston, TX. Electronic address: Ranjithrama@gmail.com.
authors: Ranjith
authors: R
authors: Ramasamy
authors: Department of Urology, Baylor College of Medicine, Houston, TX.
authors: Jason
authors: J
authors: Scovell
authors: Department of Urology, Baylor College of Medicine, Houston, TX.
authors: Michael
authors: M
authors: Mederos
authors: Department of Urology, Baylor College of Medicine, Houston, TX.
authors: Renzhong
authors: R
authors: Ren
authors: Department of Urology, Baylor College of Medicine, Houston, TX.
authors: Lakshay
authors: L
authors: Jain
authors: Department of Urology, Baylor College of Medicine, Houston, TX.
authors: Larry
authors: L
authors: Lipshultz
mesh_terms: D000368:Aged; D015331:Cohort Studies; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D013739:Testosterone / Q000009:adverse effects* / Q000627:therapeutic use; D013927:Thrombosis / Q000139:chemically induced* / Q000453:epidemiology*
chemical_list: D013739:Testosterone