title: Vigabatrin Retinal Toxicity First Detected with Electroretinographic Changes: A Case Report.
abstract: Vigabatrin is an effective antiepileptic drug (AED) typically used in the treatment of refractory partial seizures and infantile spasms. Its use, however, is limited due to the concern of retinal toxicity and subsequent visual field defects. Herewith in we describe a case of vigabatrin toxicity that illustrates electroretinographic (ERG) changes occur before imaging and visual field deterioration. Decrease in maximal ERG b: a ratio was observed before thinning of the retinal nerve fiber layer (RNFL) on optical coherence tomography (OCT).
authors: College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
authors: Dianne
authors: D
authors: Barrett
authors: Edward S. Harkness Eye Institute, Columbia University, New York, NY 10032, USA.
authors: Jin
authors: J
authors: Yang
authors: Edward S. Harkness Eye Institute, Columbia University, New York, NY 10032, USA.
authors: Tharikarn
authors: T
authors: Sujirakul
authors: Edward S. Harkness Eye Institute, Columbia University, New York, NY 10032, USA ; Bernard & Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology, Pathology & Cell Biology, Columbia University, New York, NY 10032, USA ; New York-Presbyterian Hospital/Columbia University Medical Center, New York, NY 10032, USA.
authors: Stephen H
authors: SH
authors: Tsang
keywords: Retinal toxicity; Vigabatrin