title: Development of a New Monomer for the Synthesis of Intrinsic Antimicrobial Polymers with Enhanced Material Properties.
abstract: The use of biocidal compounds in polymers is steadily increasing because it is one solution to the need for safety and hygiene. It is possible to incorporate an antimicrobial moiety to a polymer. These polymers are referred to as intrinsic antimicrobial. The biocidal action results from contact of the polymer to the microorganisms, with no release of active molecules. This is particularly important in critical fields like food technology, medicine and ventilation technology, where migration or leaching is crucial and undesirable. The isomers N-(1,1-dimethylethyl)-4-ethenyl-benzenamine and N-(1,1-dimethyl-ethyl)-3-ethenyl-benzenamine (TBAMS) are novel (Co-)Monomers for intrinsic anti-microbial polymers. The secondary amines were prepared and polymerized to the corresponding water insoluble polymer. The antimicrobial activity was analyzed by the test method JIS Z 2801:2000. Investigations revealed a high antimicrobial activity against Staphylococcus aureus and Escherichia coli with a reduction level of >4.5 log10 units. Furthermore, scanning electron microscopy (SEM) of E. coli. in contact with the polymer indicates a bactericidal action which is caused by disruption of the bacteria cell membranes, leading to lysis of the cells.
authors: Institute of Construction and Functional Materials, University of Applied Sciences Münster, Stegerwaldstraße 39, 48565 Steinfurt, Germany. f.brodkorb@fh-muenster.de.
authors: Florian
authors: F
authors: Brodkorb
authors: Institute of Construction and Functional Materials, University of Applied Sciences Münster, Stegerwaldstraße 39, 48565 Steinfurt, Germany. bjoern.fischer@fh-muenster.de.
authors: Björn
authors: B
authors: Fischer
authors: Institute of Construction and Functional Materials, University of Applied Sciences Münster, Stegerwaldstraße 39, 48565 Steinfurt, Germany. katrin.kalbfleisch@fh-muenster.de.
authors: Katrin
authors: K
authors: Kalbfleisch
authors: Institute of Construction and Functional Materials, University of Applied Sciences Münster, Stegerwaldstraße 39, 48565 Steinfurt, Germany. o.robers@fh-muenster.de.
authors: Oliver
authors: O
authors: Robers
authors: Institute of Animal Science, University Bonn, Katzenburgweg 7-9, 53113 Bonn, Germany. cbraun@uni-bonn.de.
authors: Carina
authors: C
authors: Braun
authors: Institute of Animal Science, University Bonn, Katzenburgweg 7-9, 53113 Bonn, Germany. sdohlen@uni-bonn.de.
authors: Sophia
authors: S
authors: Dohlen
authors: Institute of Animal Science, University Bonn, Katzenburgweg 7-9, 53113 Bonn, Germany. j.kreyenschmidt@uni-bonn.de.
authors: Judith
authors: J
authors: Kreyenschmidt
authors: Institute of Construction and Functional Materials, University of Applied Sciences Münster, Stegerwaldstraße 39, 48565 Steinfurt, Germany. rlorenz@fh-muenster.de.
authors: Reinhard
authors: R
authors: Lorenz
authors: Institute of Construction and Functional Materials, University of Applied Sciences Münster, Stegerwaldstraße 39, 48565 Steinfurt, Germany. martin.kreyenschmidt@fh-muenster.de.
authors: Martin
authors: M
authors: Kreyenschmidt
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011108:Polymers / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011108:Polymers
keywords: antimicrobial polymer; biocide; intrinsic antimicrobial; monomer