title: [Radiation therapy and immunomodulation: Focus on experimental data].
abstract: The immunosuppressive effects of radiation therapy have long been the only ones considered. It has been demonstrated that exposure to ionizing radiation induces the release of tumour antigens which activates both the innate immune system and the adaptive immune response of the host. The purpose of tumour immunotherapy is based on the principle that reversal of tolerance to immunogenic tumours would be able to activate an immune response against tumour cells. Preclinical data and clinical studies early phase suggest a potential therapeutic benefit of immunotherapy combined with radiation therapy. The objective of this article is to review how tumour cells interact with the immune system and how ionizing radiation modulate this interaction and finally the combination of perspectives of immunotherapy and ionizing radiation by focusing on existing clinical data.
authors: Département de radiothérapie, Gustave-Roussy Cancer Campus, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France; Radiothérapie moléculaire, Inserm U1030, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France; Faculté de médecine du Kremlin-Bicêtre, université Paris-Sud, 63, rue Gabriel-Péri, 94270 Le Kremlin-Bicêtre, France. Electronic address: deutsch@igr.fr.
authors: É
authors: É
authors: Deutsch
authors: Département de radiothérapie, Gustave-Roussy Cancer Campus, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France; Radiothérapie moléculaire, Inserm U1030, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France; Faculté de médecine du Kremlin-Bicêtre, université Paris-Sud, 63, rue Gabriel-Péri, 94270 Le Kremlin-Bicêtre, France.
authors: A
authors: A
authors: Lévy
authors: Département de radiothérapie, Gustave-Roussy Cancer Campus, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France; Radiothérapie moléculaire, Inserm U1030, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France; Faculté de médecine du Kremlin-Bicêtre, université Paris-Sud, 63, rue Gabriel-Péri, 94270 Le Kremlin-Bicêtre, France; Institut de recherche biomédicale des armées, BP 73, 91223 Brétigny-sur-Orge cedex, France.
authors: C
authors: C
authors: Chargari
mesh_terms: D006801:Humans; D056747:Immunomodulation / Q000528:radiation effects*; D009369:Neoplasms / Q000276:immunology* / Q000532:radiotherapy*
keywords: Check-points immunitaires; Immune check-points; Immunomodulation; Radiosensiblisation; Radiosenzitisation; Radiotherapy; Radiothérapie