title: Null effect of ginsenoside Rb1 on improving glycemic status in men during a resistance training recovery.
abstract: BACKGROUND
  Ginsenoside Rb1, a principle active ingredients of Panax ginseng, has been shown to lower blood glucose in animals and increase insulin secretion in cultured insulinoma cells. The aim of this study was to determine the effects of daily ginsenoside Rb1 supplementation on circulating glucose and insulin levels in men during a 5-day recovery period after an acute bout of resistance exercise.
  
  
  METHODS
  Twelve gymnasts (20.5 ± 0.3 years of age) participated in this double blind placebo-controlled crossover trial. They were challenged by a lower-limb resistance exercise at a weight load of 85 % one-repetition maximal (1-RM) for 10 repetitions, six sets of the movement. Rb1 (1 ng/kg) or Placebo was orally delivered to participants daily during a 5-day recovery period after challenge. Circulating insulin, glucose and heart rate variability (HRV) were measured under fasted condition in the morning at Days 1, Day 3, and Day 5 during recovery.
  
  
  RESULTS
  No significant effect of Rb1 on circulating glucose and insulin levels were found among participants during the 5-day recovery period. A persistent elevation in sympathetic nervous activity, indicated by increased HRV-low frequency/high frequency (HRV-LF/HF) power, during the Rb1 trial was observed.
  
  
  CONCLUSIONS
  The result of the study suggests that the null effect of Rb1 supplementation on lowering glucose and insulin levels of participants may be associated with chronic sympathetic activation.
authors: Department of Sports Sciences, Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.|Department of Physical Education, National Hsinchu University of Education, Hsinchu, Taiwan.|Department of Athletic Training and Health, National Taiwan Sport University, Taoyuan, Taiwan.
authors: Wei-Hsiang
authors: WH
authors: Chang
authors: Department of Physical Education, National Hsinchu University of Education, Hsinchu, Taiwan.
authors: Ying-Lan
authors: YL
authors: Tsai
authors: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.|Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
authors: Chih-Yang
authors: CY
authors: Huang
authors: Department of Physical Education, National Hsinchu University of Education, Hsinchu, Taiwan.
authors: City C
authors: CC
authors: Hsieh
authors: College of Sports Science and Technology, Mahidol University, Salaya, Thailand.
authors: Rungchai
authors: R
authors: Chaunchaiyakul
authors: Department of Sports Sciences, Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
authors: Yu
authors: Y
authors: Fang
authors: Department of Rehabilitation Science, China Medical University, Taichung, Taiwan.|Department of Healthcare Administration, Asia University, Taichung, Taiwan.
authors: Shin-Da
authors: SD
authors: Lee
authors: Department of Sports Sciences, Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.|Department of Rehabilitation Science, China Medical University, Taichung, Taiwan.
authors: Chia-Hua
authors: CH
authors: Kuo
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D015444:Exercise; D005215:Fasting; D036145:Ginsenosides / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D005894:Panax / Q000737:chemistry; D055070:Resistance Training; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D036145:Ginsenosides; D007328:Insulin; C442759:ginsenoside Rb1