title: Extracellular RNAs: development as biomarkers of human disease.
abstract: Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage, multiple sclerosis and placental disorders. Progress to date and the plans for future studies are outlined.
authors: Department of Neurology, Oregon Health & Science University, Portland, OR, USA; quinnj@ohsu.edu.
authors: Joseph F
authors: JF
authors: Quinn
authors: Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
authors: Tushar
authors: T
authors: Patel
authors: School of Dentistry, Department of Head and Neck Surgery, University of California at Los Angeles, Los Angeles, CA, USA.
authors: David
authors: D
authors: Wong
authors: Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors: Saumya
authors: S
authors: Das
authors: Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
authors: Jane E
authors: JE
authors: Freedman
authors: Department of Reproductive Medicine, University of California at San Diego, San Diego, CA, USA.
authors: Louise C
authors: LC
authors: Laurent
authors: Department of Neurosurgery, University of California at San Diego, San Diego, CA, USA.
authors: Bob S
authors: BS
authors: Carter
authors: Department of Neurosurgery, University of California at San Diego, San Diego, CA, USA.
authors: Fred
authors: F
authors: Hochberg
authors: Translational Genomics Research Institute, Phoenix, AZ, USA.
authors: Kendall
authors: K
authors: Van Keuren-Jensen
authors: Translational Genomics Research Institute, Phoenix, AZ, USA.
authors: Matt
authors: M
authors: Huentelman
authors: Barrow Neurological Institute, Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA.
authors: Robert
authors: R
authors: Spetzler
authors: Barrow Neurological Institute, Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA.
authors: M Yashar S
authors: MY
authors: Kalani
authors: Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA.
authors: Jorge
authors: J
authors: Arango
authors: Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA.
authors: P David
authors: PD
authors: Adelson
authors: Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: Howard L
authors: HL
authors: Weiner
authors: Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: Roopali
authors: R
authors: Gandhi
authors: Division of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: Beatrice
authors: B
authors: Goilav
authors: Division of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: Chaim
authors: C
authors: Putterman
authors: Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA; saugstad@ohsu.edu.
authors: Julie A
authors: JA
authors: Saugstad
keywords: ERCC; biomarkers; exRNA; extracellular RNA