title: Sinonasal renal cell-like adenocarcinomas: robust carbonic anhydrase expression.
abstract: We report 3 new patients with sinonasal renal cell-like adenocarcinoma (SNRCLA). One case submitted in consultation demonstrated robust carbonic anhydrase IX (CA-IX) expression, leading us to a broader inquiry of CA-IX and carbonic anhydrase II (CA-II) expression in other SNRCLA, Schneiderian tissues, and histologic mimickers. Robust cytoplasmic and membranous CA-IX expression is demonstrated in 6 of 7 SNRCLAs; CA-II expression was demonstrated in 2 of 5 cases. Robust, diffuse CA-II expression is demonstrated throughout sinonasal seromucinous glands in all 10 normal Schneiderian samples. CA-IX is also expressed in all normal sinonasal samples, albeit focally. The closest salivary mimic to SNRCLA is hyalinizing salivary clear cell carcinoma; only focal CA-IX expression was demonstrated in 1 of 2 cases studied. Carbonic anhydrase expression in Schneiderian tissue speaks to its role in regulating the ion concentration of sinonasal secretions and may also explain the origin of this rare tumor.
authors: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.
authors: Tiansheng
authors: T
authors: Shen
authors: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.
authors: Qiuying
authors: Q
authors: Shi
authors: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.
authors: Claudia
authors: C
authors: Velosa
authors: Department of Pathology, New York University Medical Center, New York, NY 10016.
authors: Shuting
authors: S
authors: Bai
authors: Department of Pathology, Southern California Permanente Medical Group, Woodland Hills, CA 91367.
authors: Lester
authors: L
authors: Thompson
authors: Department of Pathology, University of Calgary, Alberta, Canada T2L2K8.
authors: Roderick
authors: R
authors: Simpson
authors: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.
authors: Shi
authors: S
authors: Wei
authors: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294. Electronic address: MGensler@Buffalo.edu.
authors: Margaret
authors: M
authors: Brandwein-Gensler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002256:Carbonic Anhydrases / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
chemical_list: D002256:Carbonic Anhydrases
keywords: Adenocarcinoma; Carbonic anhydrase; Renal cell; Renal cell–like; Sinonasal