title: Orbito-frontal cortex and thalamus volumes in obsessive-compulsive disorder before and after pharmacotherapy.
abstract: In the present study, we focused on the key brain regions, OFC and thalamus, to investigate the roles of antiobsessional agents on volume changes of these brain regions after 12 weeks of anti-obsessional treatment in patients with obsessive-compulsive disorder (OCD). Fourteen patients with OCD and the same number of healthy controls were included in the study. At baseline, the volumes of the OFC and thalamus were compared by using magnetic resonance imaging (MRI) between groups. The volumes of OFC and thalamus were evaluated before and after the anti-obsessional drug treatment solely in the patient group. Our study revealed that thalamus volumes were reduced statistically significantly throughout the treatment period. However, we found that OFC volumes did not change statistically significantly throughout the treatment period. In summary, our study found that anti-obsessional drug treatment had an effect on thalamus volumes throughout the treatment period for both sides but not on OFC volumes. However, future studies with larger sample are required.
authors: School of Medicine, Department of Psychiatry, Firat University, Elazig, Turkey. matmaca_p@yahoo.com.|Firat Tip Merkezi, Psikiyatri Anabilim Dali, Firat (Euphrates) Universitesi, 23119, Elazig, Turkey. matmaca_p@yahoo.com.
authors: Murad
authors: M
authors: Atmaca
authors: School of Medicine, Department of Psychiatry, Firat University, Elazig, Turkey.
authors: Osman
authors: O
authors: Mermi
authors: School of Medicine, Department of Radiology, Firat University, Elazig, Turkey.
authors: Hanefi
authors: H
authors: Yildirim
authors: Elazig Mental Health Hospital, Elazig, Turkey.
authors: M Gurkan
authors: MG
authors: Gurok
mesh_terms: D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000187:drug effects*; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009929:Organ Size; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D013788:Thalamus / Q000000981:diagnostic imaging / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D011619:Psychotropic Drugs
keywords: OCD; OFC; Pharmacotherapy; Thalamus