title: Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature.
abstract: Renal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the case of a 12-year-old boy with a 2-month history of abdominal pain, unexplained weight loss, and gross hematuria. Computed tomography revealed a horseshoe kidney and a well-defined mass of 4 cm arising from the lower pole of the right kidney. Microscopically the tumor was composed of papillae covered with cells with abundant eosinophilic cytoplasm and high-grade nuclei with prominent nucleoli. Immunohistochemistry was performed; EMA, Vimentin, and AMACR were strongly positive while CK7, CD10, RCC antigen, TFE3, HMB-45, and WT-1 were negative. Currently, 10 months after the surgical procedure, the patient remains clinically and radiologically disease-free.
authors: Pathology Department, Spanish Hospital of Mexico, Ejercito Nacional 613, 11560 Mexico City, DF, Mexico.
authors: Abelardo
authors: A
authors: Loya-Solis
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Lucía
authors: L
authors: Alemán-Meza
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Luis Carlos
authors: LC
authors: Canales-Martínez
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Rodolfo
authors: R
authors: Franco-Márquez
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Alim Adriana
authors: AA
authors: Rincón-Bahena
authors: Medical Imaging Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Karla María
authors: KM
authors: Nuñez-Barragán
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Raquel
authors: R
authors: Garza-Guajardo
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Marco Antonio
authors: MA
authors: Ponce-Camacho