title: Lineage distribution and E2 sequence variation of high-risk human papillomavirus types isolated from patients with cervical cancer in Sichuan province, China.
abstract: To explore the nucleotide sequence variability of the E2 gene in high-risk HPV types in cervical cancer patients from Sichuan province, China, the E2 genes of eight high-risk HPV types were amplified and sequenced. Several novel nucleotide substitutions and deletions were observed. The lineages to which the isolates belonged were determined by phylogenetic analysis, employing the sequence of the representative lineages/sublineages in the coherent classification and nomenclature system as references. This study updates the lineage distribution data on high-risk HPV types in Southwest China and helps broaden understanding of the polymorphism of the E2 gene.
authors: Department of Gynecol Oncology, Sichuan Cancer Hospital, Chengdu, 610041, China. wuhaijing128@hotmail.com.
authors: Haijing
authors: H
authors: Wu
authors: State Nationalities Affairs Commission and Department of Educational Key Lab of Minority Traditional Medicine, Minzu University of China, Beijing, 100081, China. W1N2Q3@163.com.
authors: Enqi
authors: E
authors: Wu
authors: Health Science Center, Temple University, Philadelphia, PA, 19140, USA. tub64513@temple.edu.
authors: Lin
authors: L
authors: Ma
authors: Department of Gynecol Oncology, Sichuan Cancer Hospital, Chengdu, 610041, China. zhanggn@hotmail.com.
authors: Guonan
authors: G
authors: Zhang
authors: Department of Gynecol Oncology, Sichuan Cancer Hospital, Chengdu, 610041, China. docshiyu@163.com.
authors: Yu
authors: Y
authors: Shi
authors: Department of Molecular Pharmacology, Sichuan Cancer Hospital, Chengdu, 610041, China. wesleyhuangcn2002@163.com.
authors: Jianming
authors: J
authors: Huang
authors: Department of Molecular Pharmacology, Sichuan Cancer Hospital, Chengdu, 610041, China. zha530909@sina.com.
authors: Xiao
authors: http://orcid.org/0000-0002-4839-6898
authors: X
authors: Zha
mesh_terms: D052685:Alphapapillomavirus / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D000595:Amino Acid Sequence; D002681:China / Q000453:epidemiology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000737:chemistry / Q000235:genetics*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D010802:Phylogeny; D016415:Sequence Alignment; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology*
chemical_list: D009856:Oncogene Proteins, Viral
keywords: Cervical cancer; E2 gene; High-risk; Human papillomavirus; Variant