title: Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations.
abstract: Massively parallel sequencing technologies have enabled characterization of genomic alterations across multiple tumor types. Efforts have focused on identifying driver mutations because they represent potential targets for therapy. However, because of the presence of driver and passenger mutations, it is often challenging to assign the clinical relevance of specific mutations observed in patients. Currently, there are multiple databases and tools that provide in silico assessment for potential drivers; however, there is no comprehensive resource for mutations with functional characterization. Therefore, we created an expert-curated database of potentially actionable driver mutations for molecular pathologists to facilitate annotation of cancer genomic testing. We reviewed scientific literature to identify variants that have been functionally characterized in vitro or in vivo as driver mutations. We obtained the chromosome location and all possible nucleotide positions for each amino acid change and uploaded them to the Cancer Driver Log (CanDL) database with associated literature reference indicating functional driver evidence. In addition to a simple interface, the database allows users to download all or selected genes as a comma-separated values file for incorporation into their own analysis pipeline. Furthermore, the database includes a mechanism for third-party contributions to support updates for novel driver mutations. Overall, this freely available database will facilitate rapid annotation of cancer genomic testing in molecular pathology laboratories for mutations.
authors: Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
authors: Senthilkumar
authors: S
authors: Damodaran
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
authors: Jharna
authors: J
authors: Miya
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
authors: Esko
authors: E
authors: Kautto
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
authors: Eliot
authors: E
authors: Zhu
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
authors: Eric
authors: E
authors: Samorodnitsky
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
authors: Jharna
authors: J
authors: Datta
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
authors: Julie W
authors: JW
authors: Reeser
authors: Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio; Department of Pharmacology, The Ohio State University, Columbus, Ohio. Electronic address: sameek.roychowdhury@osumc.edu.
authors: Sameek
authors: S
authors: Roychowdhury
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D030541:Databases, Genetic; D015507:Drugs, Investigational / Q000627:therapeutic use; D052138:Genes, Neoplasm; D057166:High-Throughput Screening Assays; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*
chemical_list: D015507:Drugs, Investigational