title: Role of adult hippocampal neurogenesis in persistent pain.
abstract: The full role of adult hippocampal neurogenesis (AHN) remains to be determined, yet it is implicated in learning and emotional functions, and is disrupted in negative mood disorders. Recent evidence indicates that AHN is decreased in persistent pain consistent with the idea that chronic pain is a major stressor, associated with negative moods and abnormal memories. Yet, the role of AHN in development of persistent pain has remained unexplored. In this study, we test the influence of AHN in postinjury inflammatory and neuropathic persistent pain-like behaviors by manipulating neurogenesis: pharmacologically through intracerebroventricular infusion of the antimitotic AraC; ablation of AHN by x-irradiation; and using transgenic mice with increased or decreased AHN. Downregulating neurogenesis reversibly diminished or blocked persistent pain; oppositely, upregulating neurogenesis led to prolonged persistent pain. Moreover, we could dissociate negative mood from persistent pain. These results suggest that AHN-mediated hippocampal learning mechanisms are involved in the emergence of persistent pain.
authors: Departments of Physiology and Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA Department of Pharmacology, Columbia University, New York Psychiatric Institute, New York, NY, USA Departments of Molecular Pharmacology and Biological Chemistry and Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors: A Vania
authors: AV
authors: Apkarian
authors: Amelia A
authors: AA
authors: Mutso
authors: Maria V
authors: MV
authors: Centeno
authors: Lixin
authors: L
authors: Kan
authors: Melody
authors: M
authors: Wu
authors: Marjorie
authors: M
authors: Levinstein
authors: Ghazal
authors: G
authors: Banisadr
authors: Kevin T
authors: KT
authors: Gobeske
authors: Richard J
authors: RJ
authors: Miller
authors: Jelena
authors: J
authors: Radulovic
authors: René
authors: R
authors: Hen
authors: John A
authors: JA
authors: Kessler
mesh_terms: D000818:Animals; D002351:Carrageenan / Q000633:toxicity; D059350:Chronic Pain / Q000188:drug therapy / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D004311:Double-Blind Method; D000089622:Doublecortin Domain Proteins; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000528:radiation effects; D006026:Glycoside Hydrolases / Q000494:pharmacology; D006624:Hippocampus / Q000503:physiopathology*; D006930:Hyperalgesia / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D019964:Mood Disorders / Q000209:etiology; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D009479:Neuropeptides / Q000378:metabolism; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology; D010812:Physical Stimulation / Q000009:adverse effects; D012585:Sciatica; D013550:Swimming; D014965:X-Rays / Q000009:adverse effects
chemical_list: D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D002351:Carrageenan; D006026:Glycoside Hydrolases; C019713:alpha-N-arabinofuranosidase