title: Surface Functionalization of Chemically Reduced Graphene Oxide for Targeted Photodynamic Therapy.
abstract: In this study, using chemically reduced graphene oxide (GO) as a model nanocarbon, we successfully developed a facile surface-functionalization strategy of nanocarbons to allow both biocompatibility and receptor targeted drug delivery. Polyvinylpyrrolidone (PVP) coating improves aqueous dispersibility and biocompatibility of GO, and provides anchoring sites for ACDCRGDCFCG peptide (RGD4C). Aromatic photosensitizer chlorin e6 (Ce6) can be effectively loaded into the rGO-PVP-RGD system via hydrophobic interactions and π-π stacking. The nanodelivery system can significantly increase the accumulation of Ce6 in tumor cells and lead to an improved photodynamic therapy (PDT) efficacy as compared to Ce6 alone. The facile surface functionalization strategy can be applied to other nanomaterials such as carbon nanotubes, and inorganic nanomaterials.
authors: Peng
authors: P
authors: Huang
authors: Shouju
authors: S
authors: Wang
authors: Xiansong
authors: X
authors: Wang
authors: Guangxia
authors: G
authors: Shen
authors: Jing
authors: J
authors: Lin
authors: Zhe
authors: Z
authors: Wang
authors: Shouwu
authors: S
authors: Guo
authors: Daxiang
authors: D
authors: Cui
authors: Min
authors: M
authors: Yang
authors: Xiaoyuan
authors: X
authors: Chen
mesh_terms: D045744:Cell Line, Tumor; D002735:Chlorophyllides; D004058:Diffusion; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D011166:Porphyrins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011205:Povidone / Q000737:chemistry; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D002735:Chlorophyllides; D053769:Nanocapsules; D010087:Oxides; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin; D006108:Graphite; D011205:Povidone