title: Pulmonary Tumor Thrombotic Microangiopathy: Clinical, Radiologic, and Histologic Correlation.
abstract: Pulmonary tumor thrombotic microangiopathy (PTTM) is a clinicopathologic disease entity in which the tumor cells embolize to the pulmonary vasculature leading to a series of maladaptive reactions including the activation of coagulation and fibrocellular intimal thickening. The resultant stenosis of blood vessels leads to pulmonary hypertension and eventual death from cor pulmonale. In this report, we present a case of PTTM presenting as the initial manifestation of metastatic gastric carcinoma in a young man. Although unusual in its occurrence as the initial manifestation of gastric carcinoma, the case is illustrative in its clinical, radiological and histological presentation.
authors: Department of Medicine, Olive View - UCLA Medical Center, Sylmar, California, USA.
authors: Rohit
authors: R
authors: Godbole
authors: Division of Pulmonary and Critical Care Medicine, Olive View - UCLA Medical Center, Sylmar, California, USA.
authors: Abhijeet
authors: A
authors: Ghatol
authors: Division of Pulmonary and Critical Care Medicine, West Los Angeles Veterans Affairs Medical Center, Los Angeles, California, USA.
authors: Jamie
authors: J
authors: Betancourt
authors: Department of Pathology, Olive View - UCLA Medical Center, Sylmar, California, USA.
authors: John
authors: J
authors: Sacoolidge
authors: Division of Pulmonary and Critical Care Medicine, Olive View - UCLA Medical Center, Sylmar, California, USA.
authors: Nader
authors: N
authors: Kamangar
keywords: Cancer; embolism; pulmonary hypertension