title: Management of Infections with Drug-Resistant Organisms in Critical Care: An Ongoing Battle.
abstract: Infections with multidrug-resistant organisms (MDROs) are common in critically ill patients and are challenging to manage appropriately. Strategies that can be used in the treatment of MDRO infections in the intensive care unit (ICU) include combination therapy, adjunctive aerosolized therapy, and optimization of pharmacokinetics with higher doses or extended-infusion therapy as appropriate. Rapid diagnostic tests could assist in improving timely appropriate antimicrobial therapy for MDRO infections in the ICU.
authors: Pulmonary and Critical Care Division, Washington University School of Medicine, 660 South Euclid Avenue #8052, St Louis, MO 63110, USA.
authors: Sergio E
authors: SE
authors: Trevino
authors: Pulmonary and Critical Care Division, Washington University School of Medicine, 660 South Euclid Avenue #8052, St Louis, MO 63110, USA. Electronic address: mkollef@dom.wustl.edu.
authors: Marin H
authors: MH
authors: Kollef
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003422:Critical Care; D016638:Critical Illness; D024901:Drug Resistance, Multiple, Bacterial / Q000276:immunology*; D006801:Humans; D007362:Intensive Care Units
chemical_list: D000890:Anti-Infective Agents
keywords: Adjunctive aerosolized antimicrobial therapy; Carbapenem-resistant organisms; Initial appropriate antimicrobial therapy; Multidrug-resistant organisms