title: CRP 1846C>T Genetic Polymorphism Is Associated with Lymph Node Metastasis and/or Severe Lymphatic Invasion in Endometrial Cancer.
abstract: Endometrial cancer (EC) rates are rising in Japan. Lymph node (LN) metastasis is an important prognostic factor in EC, and its risk is increased with higher tumor grade, deep myometrial invasion, larger tumor size, and lymphovascular space invasion (LVSI). Current methodologies to assess these factors are unreliable. We previously showed the association between C-reactive protein (CRP) 1846C>T (rs1205) polymorphism and LN metastasis in esophageal, non-small cell lung, and breast cancers. The CRP gene is located on chromosome 1q21-q23, and the polymorphism in the noncoding region (1846C>T) of this gene decreases serum CRP levels. We investigated the relationship between CRP 1846C>T genetic polymorphism and LN metastasis or LVSI in 130 EC patients using polymerase chain reaction-restriction fragment length polymorphism. The CRP 1846C/T genotype was C/C in 11 patients, C/T in 58 patients and T/T in 61 patients. The patients were divided into two groups based on their CRP 1846 genotypes: "C/C" and "C/T + T/T". Nine (7%) and 18 (13%) patients, all with the polymorphism, had LN metastasis and moderate or prominent lymphatic invasion, respectively. LN metastasis and/or severe lymphatic invasion were observed in the C/T + T/T group, while patients with the C/C genotype had no LN metastases or severe lymphatic invasion. Univariate and multivariate logistic regression models revealed that the C/T + T/T patients had a significant likelihood of developing LN metastasis and/or severe lymphatic invasion. Our results suggest that CRP genetic polymorphism is a novel risk predictor of LN metastasis and/or lymphatic invasion in EC.
authors: Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine.
authors: Masahiko
authors: M
authors: Kito
authors: Satoru
authors: S
authors: Motoyama
authors: Kazuma
authors: K
authors: Fujita
authors: Masatomo
authors: M
authors: Miura
authors: Hiroshi
authors: H
authors: Nanjo
authors: Naoki
authors: N
authors: Sato
authors: Dai
authors: D
authors: Shimizu
authors: Toshiharu
authors: T
authors: Sato
authors: Kenichi
authors: K
authors: Makino
authors: Tae
authors: T
authors: Sugawara
authors: Aya
authors: A
authors: Kato
authors: Daisuke
authors: D
authors: Tamura
authors: Kazue
authors: K
authors: Takahashi
authors: Yukiyo
authors: Y
authors: Kumazawa
authors: Wataru
authors: W
authors: Sato
authors: Hiroshi
authors: H
authors: Miura
authors: Hiromitsu
authors: H
authors: Shirasawa
authors: Akira
authors: A
authors: Sato
authors: Jin
authors: J
authors: Kumagai
authors: Yukihiro
authors: Y
authors: Terada
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D002097:C-Reactive Protein