title: A Preliminary Genetic Analysis of Complement 3 Gene and Schizophrenia.
abstract: Complement pathway activation was found to occur frequently in schizophrenia, and complement 3 (C3) plays a major role in this process. Previous studies have provided evidence for the possible role of C3 in the development of schizophrenia. In this study, we hypothesized that the gene encoding C3 (C3) may confer susceptibility to schizophrenia in Han Chinese. We analyzed 7 common single nucleotide polymorphisms (SNPs) of C3 in 647 schizophrenia patients and 687 healthy controls. Peripheral C3 mRNA expression level was measured in 23 drug-naïve patients with schizophrenia and 24 controls. Two SNPs (rs1047286 and rs2250656) that deviated from Hardy-Weinberg equilibrium were excluded for further analysis. Among the remaining 5 SNPs, there was no significant difference in allele and genotype frequencies between the patient and control groups. Logistic regression analysis showed no significant SNP-gender interaction in either dominant model or recessive model. There was no significant difference in the level of peripheral C3 expression between the drug-naïve schizophrenia patients and healthy controls. In conclusion, the results of this study do not support C3 as a major genetic susceptibility factor in schizophrenia. Other factors in AP may have critical roles in schizophrenia and be worthy of further investigation.
authors: Tongde Hospital of Zhejiang Province, Zhejiang, China.
authors: Jianliang
authors: J
authors: Ni
authors: Zhejiang Provincial People's Hospital, Zhejiang, China.
authors: Shuangfei
authors: S
authors: Hu
authors: Tongde Hospital of Zhejiang Province, Zhejiang, China.
authors: Jiangtao
authors: J
authors: Zhang
authors: Hangzhou Seventh People's Hospital, Zhejiang, China.
authors: Wenxin
authors: W
authors: Tang
authors: Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Weihong
authors: W
authors: Lu
authors: Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Chen
authors: C
authors: Zhang
mesh_terms: D016022:Case-Control Studies; D003176:Complement C3 / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D003176:Complement C3; D012333:RNA, Messenger