title: Mild Cognitive Impairment, Slow Gait, and Risk of Disability: A Prospective Study.
abstract: OBJECTIVE
  Mild cognitive impairment (MCI) may be a risk for disability, and co-occurrence of slow gait (SG) and MCI may increase this risk.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  General community.
  
  
  METHODS
  The study included 3482 older adults (mean age: 71.4 years) without disability at baseline.
  
  
  METHODS
  We collected information on demographic variables, measured gait speed and cognitive function to diagnose MCI at baseline. During the follow-up period, the incident disability was monitored. Participants were divided into groups without MCI and SG (control), with SG without MCI (SG), without SG and with MCI in single (sMCI) or multiple (mMCI) domains, and with SG and MCI in single (sMCI + SG) and multiple (mMCI + SG) domains.
  
  
  RESULTS
  During follow-up, 134 participants developed disability (mean follow-up: 29.4 months). The proportions of incident disability were higher in the MCI with SG, MCI, and SG groups, compared with the control group. SG [hazard ratio 2.27 (95% confidence interval: 1.38-3.73)], mMCI [2.56 (1.31-5.02)], sMCI + SG [2.46 (1.21-5.00)], and mMCI + SG [3.48 (1.79-6.76)] participants had risks for disability.
  
  
  CONCLUSIONS
  Co-occurrence of SG and MCI in multiple domains has a higher risk of disability than each condition alone.
authors: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan; Japan Society for the Promotion of Science, Tokyo, Japan; Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan. Electronic address: take-d@ncgg.go.jp.
authors: Takehiko
authors: T
authors: Doi
authors: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
authors: Hiroyuki
authors: H
authors: Shimada
authors: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
authors: Hyuma
authors: H
authors: Makizako
authors: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
authors: Kota
authors: K
authors: Tsutsumimoto
authors: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
authors: Ryo
authors: R
authors: Hotta
authors: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
authors: Sho
authors: S
authors: Nakakubo
authors: Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
authors: Takao
authors: T
authors: Suzuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction; D006233:Persons with Disabilities; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D051346:Mobility Limitation; D011446:Prospective Studies; D018570:Risk Assessment
keywords: Cognitive function; cognitive frailty; disability; mild cognitive impairment; mobility