title: Two-photon uncageable enzyme inhibitors bearing targeting vectors.
abstract: The activity of two cyclooxygenase-2 enzyme inhibitors, Celecoxib and Lumiracoxib, could be suppressed by coupling to photo-labile protecting groups, so-called photocages. These groups could be further functionalized with a peptide targeting vector for specific cellular delivery. The enzyme inhibition potential of the cyclooxygenase-2 inhibitors could be regained upon two-photon excitation with tissue-transparent near-IR light at 800 nm.
authors: Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. gilles.gasser@chem.uzh.ch.
authors: Philipp
authors: P
authors: Anstaett
authors: Vanessa
authors: V
authors: Pierroz
authors: Stefano
authors: S
authors: Ferrari
authors: Gilles
authors: G
authors: Gasser
mesh_terms: D000068579:Celecoxib / Q000494:pharmacology*; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology*; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000494:pharmacology; D007834:Lasers; D017785:Photons
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D004008:Diclofenac; D000068579:Celecoxib; C473384:lumiracoxib