title: Patient-Specific Induced Pluripotent Stem Cells for Disease Modeling and Phenotypic Drug Discovery.
abstract: In vitro cell models are invaluable tools for studying diseases and discovering drugs. Human induced pluripotent stem cells, particularly derived from patients, are an advantageous resource for generating ample supplies of cells to create unique platforms that model disease. This manuscript will review recent developments in modeling a variety of diseases (including their cellular phenotypes) with induced pluripotent stem cells derived from patients. It will also describe how researchers have exploited these models to validate drugs as potential therapeutics for these devastating diseases.
authors: Gladstone Institutes , 1650 Owens Street, San Francisco, California 94158, United States.
authors: Shibing
authors: S
authors: Tang
authors: Gladstone Institutes , 1650 Owens Street, San Francisco, California 94158, United States.
authors: Min
authors: M
authors: Xie
authors: Gladstone Institutes , 1650 Owens Street, San Francisco, California 94158, United States.
authors: Nan
authors: N
authors: Cao
authors: Gladstone Institutes , 1650 Owens Street, San Francisco, California 94158, United States.
authors: Sheng
authors: S
authors: Ding
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D008954:Models, Biological; D010641:Phenotype; D057285:Precision Medicine; D033581:Stem Cell Transplantation / Q000379:methods*