title: Parsing Physiological Functions of Erythropoietin One Domain at a Time.
abstract: A domain of erythropoietin (EPO), separate from the domain involved in red blood cell development, has been identified. This region of EPO has anti-inflammatory and neuroprotective effects. Use of a peptide sequence from this region provides the potential for an effective therapeutic without effects on erythropoiesis.
authors: Neurology and Neuroscience, Stanford University School of Medicine, Stanford, CA, 94305, USA. steinman@stanford.edu.
authors: Lawrence
authors: L
authors: Steinman
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D004921:Erythropoietin / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D017434:Protein Structure, Tertiary
chemical_list: D000893:Anti-Inflammatory Agents; D018696:Neuroprotective Agents; D004921:Erythropoietin
keywords: Erythropoietin; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Neuroprotection