title: Remote effects of extracorporeal shock wave therapy on cutaneous microcirculation.
abstract: BACKGROUND
  Extracorporeal shock wave treatment (ESWT) has proven its clinical benefits in different fields of medicine. Tissue regeneration and healing is improved after shock wave treatment. Even in the case of burn wounds angiogenesis and re-epithelialization is accelerated, but ESWT in extensive burn wounds is impracticable.
  
  
  OBJECTIVE
  High energy ESWT influences cutaneous microcirculation at body regions remote from application site.
  
  
  METHODS
  Eighteen Sprague Dawley rats were randomly assigned to two groups and received either high energy ESWT (Group A: total 1000 impulses, 10 J) or placebo shock wave treatment (Group B: 0 impulses, 0 J), applied to the dorsal lower leg of the hind limb. Ten minutes later microcirculatory effects were assessed at the contralateral lower leg of the hind limb (remote body region) by combined Laser-Doppler-Imaging and Photospectrometry.
  
  
  RESULTS
  In Group A cutaneous capillary blood velocity was significantly increased by 152.8% vs. placebo ESWT at the remote body location (p = 0.01). Postcapillary venous filling pressure remained statistically unchanged (p > 0.05), while cutaneous tissue oxygen saturation increased by 12.7% in Group A (p = 0.220).
  
  
  CONCLUSIONS
  High energy ESWT affects cutaneous hemodynamics in body regions remote from application site in a standard rat model. The results of this preliminary study indicate that ESWT might be beneficial even in disseminated and extensive burn wounds by remote shock wave effects and should therefore be subject to further scientific evaluation.
authors: Department of Plastic Surgery, Hand Surgery, Burn Unit, University Hospital Schleswig-Holstein Campus Lübeck, University of Lübeck, Germany. Electronic address: tobias.kisch@uksh.de.
authors: Tobias
authors: T
authors: Kisch
authors: Department for Plastic, Reconstructive and Aesthetic Surgery, Hand Surgery, Alfried Krupp Hospital, Essen, Germany.
authors: Heiko
authors: H
authors: Sorg
authors: Department of Visceral and Thoracic Surgery, German Armed Forces Hospital Ulm, Ulm, Germany.
authors: Vinzent
authors: V
authors: Forstmeier
authors: Sportpractice Prof. Knobloch, Hannover, Germany.
authors: Karsten
authors: K
authors: Knobloch
authors: Department of Plastic Surgery, Hand Surgery, Burn Unit, University Hospital Schleswig-Holstein Campus Lübeck, University of Lübeck, Germany.
authors: Eirini
authors: E
authors: Liodaki
authors: Department of Plastic Surgery, Hand Surgery, Burn Unit, University Hospital Schleswig-Holstein Campus Lübeck, University of Lübeck, Germany.
authors: Felix
authors: F
authors: Stang
authors: Department of Plastic Surgery, Hand Surgery, Burn Unit, University Hospital Schleswig-Holstein Campus Lübeck, University of Lübeck, Germany.
authors: Peter
authors: P
authors: Mailänder
authors: Department of Plastic Surgery, Hand Surgery, Burn Unit, University Hospital Schleswig-Holstein Campus Lübeck, University of Lübeck, Germany.
authors: Robert
authors: R
authors: Krämer
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000528:radiation effects*; D002056:Burns / Q000532:radiotherapy; D019220:High-Energy Shock Waves; D006614:Hindlimb; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D062326:Re-Epithelialization / Q000528:radiation effects; D012867:Skin / Q000098:blood supply* / Q000528:radiation effects*; D014945:Wound Healing / Q000528:radiation effects
keywords: Cutaneous microcirculation; Disseminated burn wounds; Laser Doppler; Remote ESWT; Shock wave