title: Making a Choice: How Cadherin Switching Controls Cell Migration.
abstract: Cells that undergo epithelial-to-mesenchymal transitions (EMTs) commonly switch from expressing E-cadherin to N-cadherin. But why this occurs is not well understood. In the current issue of Developmental Cell, Scarpa et al. (2015) identify a reason: cadherin switching controls Rac signaling to determine how cell locomotion is regulated by contact.
authors: Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia.
authors: Rashmi
authors: R
authors: Priya
authors: Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia. Electronic address: a.yap@imb.uq.edu.au.
authors: Alpha S
authors: AS
authors: Yap
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002465:Cell Movement; D016764:Cell Polarity; D003260:Contact Inhibition; D058750:Epithelial-Mesenchymal Transition; D009432:Neural Crest / Q000166:cytology*
chemical_list: D015820:Cadherins