title: In vitro interactions of antifungal agents and tacrolimus against Aspergillus biofilms.
abstract: Aspergillus biofilms were prepared from Aspergillus fumigatus, Aspergillus flavus, and Aspergillus terreus via a 96-well plate-based method, and the combined antifungal activity of tacrolimus with azoles or amphotericin B against Aspergillus biofilms was investigated via a broth microdilution checkerboard technique system. Our results suggest that combinations of tacrolimus with voriconazole or amphotericin B have synergistic inhibitory activity against Aspergillus biofilms. However, combinations of tacrolimus with itraconazole or posaconazole exhibit no synergistic or antagonistic effects.
authors: Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
authors: Lujuan
authors: L
authors: Gao
authors: Department of Dermatology, Jingzhou Central Hospital, Jingzhou City, Hubei Province, People's Republic of China 710514760@qq.com.
authors: Yi
authors: Y
authors: Sun
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects*; D016559:Tacrolimus / Q000494:pharmacology*; D065819:Voriconazole / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D065819:Voriconazole; D016559:Tacrolimus