title: Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm.
abstract: The aortic wall is perfused by the adventitial vasa vasorum (VV). Tissue hypoxia has previously been observed as a manifestation of enlarged abdominal aortic aneurysms (AAAs). We sought to determine whether hypoperfusion of the adventitial VV could develop AAAs. We created a novel animal model of adventitial VV hypoperfusion with a combination of a polyurethane catheter insertion and a suture ligation of the infrarenal abdominal aorta in rats. VV hypoperfusion caused tissue hypoxia and developed infrarenal AAA, which had similar morphological and pathological characteristics to human AAA. In human AAA tissue, the adventitial VV were stenotic in both small AAAs (30-49 mm in diameter) and in large AAAs (> 50 mm in diameter), with the sac tissue in these AAAs being ischemic and hypoxic. These results indicate that hypoperfusion of adventitial VV has critical effects on the development of infrarenal AAA.
authors: Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan; Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Hiroki
authors: H
authors: Tanaka
authors: Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University, Nara, Japan.
authors: Nobuhiro
authors: N
authors: Zaima
authors: Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Takeshi
authors: T
authors: Sasaki
authors: Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Masaki
authors: M
authors: Sano
authors: Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Naoto
authors: N
authors: Yamamoto
authors: Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Takaaki
authors: T
authors: Saito
authors: Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Kazunori
authors: K
authors: Inuzuka
authors: Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan; Health Innovation & Technology Center, Hokkaido University, Sapporo, Japan.
authors: Takahiro
authors: T
authors: Hayasaka
authors: Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Health Promotion Science, Tokyo Metropolitan University, Tokyo, Japan.
authors: Naoko
authors: N
authors: Goto-Inoue
authors: Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan.
authors: Yuki
authors: Y
authors: Sugiura
authors: Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Kohji
authors: K
authors: Sato
authors: Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University, Nara, Japan.
authors: Hirona
authors: H
authors: Kugo
authors: Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University, Nara, Japan.
authors: Tatsuya
authors: T
authors: Moriyama
authors: Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Hiroyuki
authors: H
authors: Konno
authors: Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Mitsutoshi
authors: M
authors: Setou
authors: Division of Vascular Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Naoki
authors: N
authors: Unno
mesh_terms: D000368:Aged; D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D001775:Blood Circulation; D003251:Constriction, Pathologic / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014651:Vasa Vasorum / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*
chemical_list: D010100:Oxygen