title: Photoacoustic- and Magnetic Resonance-Guided Photothermal Therapy and Tumor Vasculature Visualization Using Theranostic Magnetic Gold Nanoshells.
abstract: Nanoparticle based image-guided therapy is an emerging technology for cancer in recent years. Here, we report simultaneous photoacoustic (PA)- and magnetic resonance (MR)-guided photothermal ablation (PTA) therapy using multifunctional superparamagnetic iron oxide-containing gold nanoshells (SPIO@AuNS). Based on the intrinsic high near-infrared optical absorbance and strong magnetic property of SPIO@AuNS, we carried out in vivo dual-modality PA-MR imaging of mouse tumors. PA- and MR-guided imaging can monitor therapeutic effect after photothermal therapy mediated by our multifunctional nanomaterial. In addition, using our pulsed laser PA technique, we also observe a clearer structure of the tumor vasculature after intravenously administration SPIO@AuNS. The novel dual PA-MRI image-guided PTA therapy provides a promising new platform for cancer diagnosis and treatment simultaneously.
authors: Min
authors: M
authors: Zhou
authors: Burapol
authors: B
authors: Singhana
authors: Yang
authors: Y
authors: Liu
authors: Qian
authors: Q
authors: Huang
authors: Trevor
authors: T
authors: Mitcham
authors: Michael J
authors: MJ
authors: Wallace
authors: R Jason
authors: RJ
authors: Stafford
authors: Richard R
authors: RR
authors: Bouchard
authors: Marites P
authors: MP
authors: Melancon
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003911:Dextrans / Q000737:chemistry; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006046:Gold / Q000627:therapeutic use; D006979:Hyperthermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000601:surgery; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome
chemical_list: D003911:Dextrans; D058185:Magnetite Nanoparticles; C097921:ferumoxtran-10; D006046:Gold