title: Prenatal Exposure to Cadmium and Cotinine and CpG island DNA methylation in Mother-Infant Pairs.
abstract: A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n=16,421) in leukocytes collected from mothers and their infants from a pregnancy cohort in Durham County, North Carolina. The CpG methylation levels were examined in relationship to prenatal exposure to cadmium and/or cotinine to identify genes and pathways influenced byinutero exposure. In the present article, we provide an enhanced description of the data collection and processing to facilitate cross-study comparisons. Data are available within the Gene Expression Omnibus database (GSE67976).
authors: Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
authors: Saideep
authors: S
authors: Gona
authors: Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors: Alison P
authors: AP
authors: Sanders
authors: Department of Statistics, Rice University, Houston, TX, USA.
authors: Marie Lynn
authors: ML
authors: Miranda
authors: Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA ; Curriculum in Toxicology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
authors: Rebecca C
authors: RC
authors: Fry