title: Hyperinsulinism and polycystic ovary syndrome (PCOS): role of insulin clearance.
abstract: OBJECTIVE
  Insulin resistance and compensatory hyperinsulinism are the predominant metabolic defects in polycystic ovary syndrome (PCOS). However, hyperinsulinism, as well as being compensatory, can also express a condition of reduced insulin clearance. Our aim was to evaluate the differences in insulin action and metabolism between women with PCOS (with normal glucose tolerance) and age- and BMI-matched women with prediabetes (without hyperandrogenism and ovulatory disorders).
  
  
  METHODS
  22 women with PCOS and 21 age/BMI-matched women with prediabetes were subjected to a Hyperinsulinemic-euglycemic clamp and an Oral Glucose tolerance Test (OGTT). Insulin sensitivity was assessed by the glucose infusion rate during clamp (M value); insulin secretion by Insulinogenic index, Oral Disposition Index (DIo) and AUC(2h-insulin) during OGTT; and insulin clearance by the metabolic clearance rate of insulin (MCRI) during clamp.
  
  
  RESULTS
  Women with PCOS showed significantly higher levels of AUC(2h-insulin) (p < 0.011), Insulinogenic Index (p < 0.001), DIo (p = 0.002) and significantly lower levels of AUC(2h-glucos)e (p = 0.001). No difference was found between the two groups regarding insulin sensitivity (M value). Lower levels of MCRI were found in women with PCOS [420 (IQR 227-588) vs. 743 (IQR 597-888) ml m(-2) min(-1): p < 0.001]. Furthermore, in the PCOS group, a strong independent inverse correlation was only observed between MCRI and AUC(2h-insulin) (PCOS: β:-0.878; p < 0.001; Prediabetes: β:-0.501; p = 0.019).
  
  
  CONCLUSIONS
  Our study suggests that in normoglycemic women with PCOS there is peripheral insulin sensitivity similar to that of women with prediabetes. What sets PCOS apart is the hyperinsulinism, today still simplistically defined "compensatory"; actually this is mainly related to decreased insulin clearance whose specific causes and dynamics have yet to be clarified.
authors: Section of Endocrinology, Diabetology and Metabolism, Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy.
authors: M C
authors: MC
authors: Amato
authors: Section of Endocrinology, Diabetology and Metabolism, Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy.
authors: R
authors: R
authors: Vesco
authors: Section of Endocrinology, Diabetology and Metabolism, Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy.
authors: E
authors: E
authors: Vigneri
authors: Section of Endocrinology, Diabetology and Metabolism, Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy.
authors: A
authors: A
authors: Ciresi
authors: Section of Endocrinology, Diabetology and Metabolism, Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy. carlagiordano53@gmail.com.
authors: C
authors: C
authors: Giordano
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011236:Prediabetic State / Q000097:blood*; D055815:Young Adult
chemical_list: D007328:Insulin
keywords: Clamp; Hyperinsulinism; Insulin clearance; Insulin resistance; PCOS