title: Fine needle aspiration of secondary synovial sarcoma of the thyroid gland.
abstract: Synovial sarcomas (SS) of the head and neck region are extremely rare and arise in only 5% of cases. We present a case of secondary SS of the thyroid originally diagnosed as medullary carcinoma on fine needle aspiration (FNA). A 41-year-old man presented with several weeks of dysphonia and a left thyroid mass. FNA of the thyroid nodule showed a cellular smear composed of loosely cohesive oval to spindle-shaped cells with irregular nuclear borders, finely granular chromatin, and inconspicuous nucleoli. The patient was diagnosed with medullary carcinoma and underwent a total thyroidectomy. Intro-operatively, the mass was found to arise from the tracheoesophageal groove with spread to the left thyroid. Microscopic examination of the thyroid tumor revealed a dense spindle cell proliferation with abundant mitoses, scant cords and nests of epithelial cells and foci of necrosis. The spindle cells were positive for bcl2 and vimentin and the epithelial cells were positive for cytokeratin 8/18 and epithelial membrane antigen (EMA). Both spindle and epithelial cells were negative for thyroglobulin, calcitonin, synaptophysin and chromogranin. Fluorescence in situ hybridization (FISH) demonstrated translocation (X;18)(p11;q11), confirming the diagnosis of SS. The patient underwent a total laryngopharyngoesophagectomy with subsequent adjuvant therapy and is currently disease free. Only 6 cases of histologically confirmed primary SS of the thyroid have been reported. To the best of our knowledge, this is the first case of FISH-confirmed secondary SS of the thyroid and also the first case of SS arising from the tracheoesophageal groove.
authors: Department of Pathology, Rush University Medical Center, Chicago, Illinois.
authors: Diana
authors: D
authors: Murro
authors: Department of Pathology, Rush University Medical Center, Chicago, Illinois.
authors: Jamie Macagba
authors: JM
authors: Slade
authors: Department of Pathology, Rush University Medical Center, Chicago, Illinois.
authors: Sahr
authors: S
authors: Syed
authors: Department of Pathology, Rush University Medical Center, Chicago, Illinois.
authors: Paolo
authors: P
authors: Gattuso
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle / Q000379:methods; D018276:Carcinoma, Medullary / Q000175:diagnosis / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D008297:Male; D013584:Sarcoma, Synovial / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary*; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology; D016606:Thyroid Nodule / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: fine needle aspiration; medullary thyroid carcinoma; secondary thyroid malignancies; synovial sarcoma; tracheoesophageal