title: Clinical and microbiological efficacy of 3% satranidazole gel as a local drug delivery system in the treatment of chronic periodontitis: A randomized, controlled clinical trial.
abstract: OBJECTIVE
  The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.
  
  
  METHODS
  Seventy subjects with probing depth (PD) ≥5 mm were selected. Thirty-five subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index, gingival index, clinical attachment level (CAL), and PD at baseline; 1 month, 3 months, and 6 months interval. Furthermore, microbial analysis using polymerase chain reaction was done to estimate the number of sites harboring periodontopathogens.
  
  
  RESULTS
  Sixty four subjects were evaluated up to 6 months. At 6 months, the Group 2 resulted in greater mean reduction (4.10 mm) in PD as compared to Group 1 (1.49 mm), and also a greater mean CAL gain (4.20 mm) in Group 2 as compared to Group 1 (1.13 mm). These subjects also showed a significant reduction in the number of sites harboring periodontopathogens.
  
  
  CONCLUSIONS
  The use of 3% SZ gel, when used as an adjunct to nonsurgical periodontal therapy in subjects with periodontitis, achieved better results than initial periodontal treatment alone.
authors: Department of Periodontics, Government Dental College and Research Institute, Bengaluru, India.
authors: N
authors: N
authors: Priyanka
authors: Department of Periodontics, Government Dental College and Research Institute, Bengaluru, India.
authors: Nitish
authors: N
authors: Kalra
authors: Department of Periodontics, Yogita Dental College and Hospital, Khed, Ratnagiri, Maharashtra, India.
authors: Shahab
authors: S
authors: Saquib
authors: Department of Periodontics, Himachal Dental College, Sundernagar, Himachal Pradesh, India.
authors: Nitin
authors: N
authors: Kudyar
authors: Department of Oral Pathology, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia.
authors: Nikhil
authors: N
authors: Malgaonkar
authors: Department of Oral Surgery, Yogita Dental College and Hospital, Khed, Ratnagiri, Maharashtra, India.
authors: Hunny
authors: H
authors: Jain
authors: Department of Periodontics, Government Dental College and Research Institute, Bengaluru, India.
authors: A R
authors: AR
authors: Pradeep
keywords: Chronic periodontitis; local drug delivery; satranidazole; scaling and root planing