title: Premedication dilemmas, is Pregabalin the answer?
abstract: OBJECTIVE
  Laryngoscopy and intubation are associated with sympathetic stimulation which can prove deleterious in patients with cardiovascular compromise; so, various methods have been tried to obtund this pressor response. In this study, we have assessed the efficacy of pregabalin in attenuating the pressor response to laryngoscopy and intubation.
  
  
  METHODS
  This prospective randomized study included 80 patients with American Society of Anesthesiologists physical status grades I-II, in the age group of 18-60 years of age. The patients were randomized into two groups of 40 patients each. Group A received the placebo orally, 90 min prior to surgery. Group B received 150 mg of pregabalin orally, 90 min prior to surgery. These patients were assessed in terms of sedation with Ramsay sedation scale (RSS). In the operation theatre, the heart rate (HR), systolic blood pressure, diastolic blood pressure, mean arterial pressure, and oxygen saturation recorded at baseline and 1, 3, 5, and 10 min after intubation. The rate pressure product (RPP) was calculated for these time intervals. In the postoperative period, patients were assessed for complications like dizziness, nausea, and blurred vision. Statistical analysis was performed using Chi-square and ANOVA tests.
  
  
  RESULTS
  The group receiving 150 mg of pregabalin as premedication was found to be adequately sedated at 1 h post-premedication with 52% patients having a RSS score of 3 compared to 4% with the same RSS score in the placebo group (P < 0.0001). Hemodynamics was more stable post-intubation with significant stability in the HR (P = 0.002) and RPP (P = 0.004) in the pregabalin group.
  
  
  CONCLUSIONS
  Pregabalin when given as a premedication provides adequate sedation and obtunds the pressor response seen with intubation.
authors: Department of Anesthesiology, Christian Medical College, Ludhiana, Punjab, India.
authors: Preetha Elizabeth
authors: PE
authors: George
authors: Department of Anesthesiology, Christian Medical College, Ludhiana, Punjab, India.
authors: Reetika
authors: R
authors: Chander
authors: Department of Anesthesiology, Christian Medical College, Ludhiana, Punjab, India.
authors: Dootika
authors: D
authors: Liddle
authors: Department of Anesthesiology, Christian Medical College, Ludhiana, Punjab, India.
authors: Valsamma
authors: V
authors: Abraham
keywords: Laryngoscopy; Pregabalin; Ramsay sedation scale; pressor response; rate pressure product