title: Carbon Multiplicity Editing in Long-Range Heteronuclear Correlation NMR Experiments: A Valuable Tool for the Structure Elucidation of Natural Products.
abstract: A recently developed NMR method to simultaneously obtain both long-range heteronuclear correlations and carbon multiplicity information in a single experiment, ME-selHSQMBC, is demonstrated as a potentially useful technique for chemical shift assignment and structure elucidation of natural products presenting complicated NMR spectra. Carbon multiplicities, even for C/CH2 and odd for CH/CH3 resonances, can be distinguished directly from the relative positive/negative phase of cross-peaks. In addition, connectivity networks can be further extended by incorporating a TOCSY propagation step. Staurosporine (1) and sungucine (2) are utilized as model compounds to demonstrate these techniques.
authors: NMR Structure Elucidation, Process and Analytical Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors: Josep
authors: J
authors: Saurí
authors: Laboratory of Pharmacognosy, Department of Pharmacy, CIRM, University of Liège , B36, 4000 Liège, Belgium.
authors: Michel
authors: M
authors: Frédérich
authors: Center for Studies on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM) , P.O. Box 6163, Yaoundé, Cameroon.
authors: Alembert T
authors: AT
authors: Tchinda
authors: Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona , E-08193 Bellaterra, Barcelona, Spain.
authors: Teodor
authors: T
authors: Parella
authors: NMR Structure Elucidation, Process and Analytical Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors: R Thomas
authors: RT
authors: Williamson
authors: NMR Structure Elucidation, Process and Analytical Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors: Gary E
authors: GE
authors: Martin
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D019311:Staurosporine / Q000737:chemistry; D013331:Strychnine / Q000737:chemistry
chemical_list: D001688:Biological Products; C464946:sungucine; D002244:Carbon; D019311:Staurosporine; D013331:Strychnine