title: EN FACE OPTICAL COHERENCE TOMOGRAPHY OF MACULAR MICROCYSTS DUE TO OPTIC NEUROPATHY FROM NEUROMYELITIS OPTICA.
abstract: OBJECTIVE
  To describe the multimodal imaging, including en face optical coherence tomography (OCT) and OCT angiography, findings of a case of macular microcysts associated with neuromyelitis optica.
  
  
  METHODS
  Findings on clinical examination, color fundus photography, fluorescein angiography, fundus autofluorescence, visual fields, and OCT including en face OCT and OCT angiography are presented.
  
  
  RESULTS
  A 12-year-old African American boy presented with bilateral optic atrophy from neuromyelitis optica. Clinical examination was notable for bilateral optic nerve head pallor. Visual fields of both eyes showed generalized depression. Fluorescein angiography and fundus autofluorescence were unremarkable. Spectral domain OCT B-scan images showed characteristic paracentral, hyporeflective, microcystic lesions in the inner nuclear layer of both eyes, and en face OCT images demonstrated a corresponding pattern of large paracentral cysts radiating peripherally into smaller diffuse cysts. Optical coherence tomographic angiography of the superficial and deep retinal capillary plexuses was unremarkable.
  
  
  CONCLUSIONS
  Macular microcysts have been associated with various forms of optic atrophy, including neuromyelitis optica. Spectral domain and en face OCT imaging of the microcysts demonstrated a very characteristic pattern. Normal fluorescein and OCT angiography suggest that nonvascular causes, such as Müller cell degeneration, might contribute to the etiologic mechanism.
authors: *Department of Ophthalmology, Stein Eye Institute, University of California Los Angeles, Los Angeles, California; †Department of Ophthalmology, Doheny Eye Institute, University of California Los Angeles, Los Angeles, California; ‡Pediatrics Eye Associates, Tulsa, Oklahoma; §Department of Pediatric Neurology, Kaiser Permanente Downey Medical Center, Los Angeles, California; and ¶Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California.
authors: Xuejing
authors: X
authors: Chen
authors: Laura
authors: L
authors: Kuehlewein
authors: Stacy L
authors: SL
authors: Pineles
authors: Anika K
authors: AK
authors: Tandon
authors: Shelley X
authors: SX
authors: Bose
authors: Michael A
authors: MA
authors: Klufas
authors: Srinivas R
authors: SR
authors: Sadda
authors: David
authors: D
authors: Sarraf
mesh_terms: D002648:Child; D003560:Cysts / Q000175:diagnosis*; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009471:Neuromyelitis Optica / Q000175:diagnosis*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012164:Retinal Diseases / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*