title: A highly enantioselective, organocatalytic [3+2]-cycloannulation reaction towards the de novo-synthesis of 1-cyclopentenyl-α-keto esters.
abstract: We disclose herein a highly enantioselective de novo-synthesis of chiral 1-cyclopentenyl-α-keto esters starting from a simple bis-silyl-1,3-dienediolate and α,β-unsaturated aldehydes via a domino vinylogous Michael-intramolecular Knoevenagel-type condensation. The cyclopentenes proved to be highly versatile and were readily converted into various structural motifs.
authors: Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, D-4103 Leipzig, Germany. schneider@chemie.uni-leipzig.de.
authors: Pradeep R
authors: PR
authors: Nareddy
authors: Christoph
authors: C
authors: Schneider