title: Auditory nerve impulses induced by 980 nm laser.
abstract: The discovery that a pulsed laser could trigger an auditory neural response inspired ongoing research on cochlear implants activated by optical stimulus rather than by electrical current. However, most studies to date have used visible light (532 nm) or long-wavelength near-infrared (>1840  nm ) and involved making a hole in the cochlea. This paper investigates the effect of optical parameters on the optically evoked compound action potentials (oCAPs) from the guinea pig cochlea, using a pulsed semiconductor near-infrared laser (980 nm) without making a hole in the cochlea. Synchronous trigger laser pulses were used to stimulate the cochlea, before and after deafening, upon varying the pulse duration (30–1000  μs ) and an amount of radiant energy (0–53.2  mJ/cm 2 ). oCAPs were successfully recorded after deafening. The amplitude of the oCAPs increased as the infrared radiant energy was increased at a fixed 50  μs pulse duration, and decreased with a longer pulse duration at a fixed 37.1  mJ/cm 2 radiant energy. The latency of the oCAPs shortened with increasing radiant energy at a fixed pulse duration. With a higher stimulation rate, the amplitude of the oCAPs’ amplitude decreased.
authors: Tsinghua University, Graduate School at Shenzhen, Research Center of Biomedical Engineering, Shenzhen, Guangdong 518055, China.
authors: Tian
authors: T
authors: Guan
authors: Tsinghua University, Graduate School at Shenzhen, Research Center of Biomedical Engineering, Shenzhen, Guangdong 518055, ChinabTsinghua University, School of Medicine, Department of Biomedical Engineering, Beijing 100084, China.
authors: Kai
authors: K
authors: Zhu
authors: South University of Science and Technology of China, Department of Electrical and Electronic Engineering, No. 1088, Xueyuan Road, Xili, Nanshan District, Shenzhen, Guangdong 518055, China.
authors: Fei
authors: F
authors: Chen
authors: Tsinghua University, Graduate School at Shenzhen, Laboratory of Optical Imaging and Sensing, Shenzhen, Guangdong 518055, China.
authors: Yonghong
authors: Y
authors: He
authors: Shenzhen Institute of Information Technology, School of Electronics and Communication, Shenzhen, Guangdong 518172, China.
authors: Jian
authors: J
authors: Wang
authors: Tsinghua University, Graduate School at Shenzhen, Research Center of Biomedical Engineering, Shenzhen, Guangdong 518055, ChinabTsinghua University, School of Medicine, Department of Biomedical Engineering, Beijing 100084, China.
authors: Mocun
authors: M
authors: Wu
authors: Peking University Shenzhen Hospital, Department of Otolaryngology, No. 1120, Lianhua Road, Futain District, Shenzhen, Guangdong 518036, China.
authors: Guohui
authors: G
authors: Nie
mesh_terms: D000200:Action Potentials / Q000502:physiology* / Q000528:radiation effects; D000818:Animals; D003056:Cochlear Nerve / Q000502:physiology* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005072:Evoked Potentials, Auditory / Q000502:physiology* / Q000528:radiation effects; D005260:Female; D006168:Guinea Pigs; D007834:Lasers; D008297:Male; D010775:Photic Stimulation / Q000379:methods*; D011829:Radiation Dosage