title: Natural products: Perspectives in the pharmacological treatment of gastrointestinal anisakiasis.
abstract: OBJECTIVE
  To evaluate the activity of different natural products against L3 larvae of Anisakis type I.
  
  
  METHODS
  Information on investigations into the activity of natural products against the L3 larvae of Anisakis simplex was collected from scientific journals, books, theses and reports via a library and electronic search (using Pubmed, Scopus, Medline, Web of Science and ScienceDirect). The search terms included: natural products, medicinal plants, essential oils, terpenic derivatives, Anisakis, antinematodal activity.
  
  
  RESULTS
  In the literature reviewed numerous papers were found concerning the in vitro and in vivo activity against Anisakis type I of various natural products (plant extracts, essential oils and their major components). Analysis of the results showed that in vitro tests the Melaleuca alternifolia essential oil and the ar-turmerone isolated from Curcuma longa displayed the greatest activity. In vivo, the most active compound was perillaldehyde, the main component of Perilla frutescens essential oil.
  
  
  CONCLUSIONS
  This study shows that some natural products exhibited promising antianisakis properties.
authors: Department of Parasitology, Faculty of Pharmacy, University of Granada, Spain.
authors: A
authors: A
authors: Valero
authors: Department of Parasitology, Faculty of Pharmacy, University of Granada, Spain.
authors: M C
authors: MC
authors: Romero
authors: Department of Parasitology, Faculty of Pharmacy, University of Granada, Spain. Electronic address: magda86@correo.ugr.es.
authors: M
authors: M
authors: Gómez-Mateos
authors: Department of Parasitology, Faculty of Pharmacy, University of Granada, Spain.
authors: I
authors: I
authors: Hierro
authors: Department of Pharmacology, Faculty of Pharmacy, University of Granada, Spain.
authors: M C
authors: MC
authors: Navarro
keywords: Anisakiasis; Anisakis; Essential oils; Natural products; Terpenic derivatives