title: A Study on MTHFR C677T Gene Polymorphism and Alcohol Dependence among Meiteis of Manipur, India.
abstract: Chronic alcohol consumption is reported to be associated with increase in plasma homocysteine levels which is further influenced by the polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene. The present study aims to understand the extent of the MTHFR C677T polymorphism in alcohol dependent (AD) cases of Meiteis of Manipur, a Mendelian population of India. MTHFR C677T polymorphism was screened in 313 controls and 139 alcohol dependent (AD) cases who all met DSM-IV criteria for alcohol dependence. Both AD cases and controls were unrelated up to 1st cousin. Among the control group, different drinking patterns like abstainer/nondrinkers (NDs), occasional drinkers (ODs), and moderate drinkers (MDs) are included. Both the groups were found to be in Hardy-Weinberg equilibrium (P > 0.05). Genotypic and allelic frequency distribution of MTHFR C677T polymorphism did not differ significantly between AD cases and controls (P > 0.05). However, individuals carrying mutant (T) allele show more than 1-fold increased risk for AD though not significant (OR = 1.43; 95% CI 0.41-5.01, P > 0.05). In conclusion, MTHFR C677T polymorphism is not found to be risk marker for AD in present studied population. However, higher prevalence of the mutant T allele may exacerbate deleterious health risk in future especially among alcohol drinkers.
authors: Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi, Delhi 110007, India ; Department of Anthropology and Tribal Development, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh 495009, India.
authors: Huidrom Suraj
authors: HS
authors: Singh
authors: Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi, Delhi 110007, India ; The INCLEN Trust International, Okhla Industrial Area, Phase I, New Delhi 110020, India.
authors: Kabita
authors: K
authors: Salam
authors: Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi, Delhi 110007, India.
authors: Kallur Nava
authors: KN
authors: Saraswathy