title: In vivo free-breathing DTI and IVIM of the whole human heart using a real-time slice-followed SE-EPI navigator-based sequence: A reproducibility study in healthy volunteers.
abstract: In this study, we proposed an efficient free-breathing strategy for rapid and improved cardiac diffusion-weighted imaging (DWI) acquisition using a single-shot spin-echo echo planar imaging (SE-EPI) sequence.
  
  
  
  A real-time slice-following technique during free-breathing was combined with a sliding acquisition-window strategy prior Principal Component Analysis temporal Maximum Intensity Projection (PCAtMIP) postprocessing of in-plane co-registered diffusion-weighted images. This methodology was applied to 10 volunteers to quantify the performance of the motion correction technique and the reproducibility of diffusion parameters.
  
  
  
  The slice-following technique offers a powerful head-foot respiratory motion management solution for SE-EPI cDWI with the advantage of a 100% duty cycle scanning efficiency. The level of co-registration was further improved using nonrigid motion corrections and was evaluated with a co-registration index. Vascular fraction f and the diffusion coefficients D and D* were determined to be 0.122 ± 0.013, 1.41 ± 0.09 × 10(-3) mm(2) /s and 43.6 ± 9.2 × 10(-3) mm(2) /s, respectively. From the multidirectional dataset, the measured mean diffusivity was 1.72 ± 0.09 × 10(-3) mm(2) /s and the fractional anisotropy was 0.36 ± 0.02.
  
  
  
  The slice-following DWI SE-EPI sequence is a promising solution for clinical implementation, offering a robust improved workflow for further evaluation of DWI in cardiology. Magn Reson Med 76:70-82, 2016. © 2015 Wiley Periodicals, Inc.
authors: CREATIS; CNRS (UMR 5220); INSERM (U1044); INSA Lyon; Université de Lyon, Lyon, France.|Siemens Healthcare France, Saint-Denis, France.
authors: Kevin
authors: K
authors: Moulin
authors: CREATIS; CNRS (UMR 5220); INSERM (U1044); INSA Lyon; Université de Lyon, Lyon, France.|Department of Radiology, Centre Hospitalier Universitaire de Saint-Etienne, Université Jean-Monnet, France.
authors: Pierre
authors: P
authors: Croisille
authors: Siemens Healthcare, Erlangen, Germany.
authors: Thorsten
authors: T
authors: Feiweier
authors: CREATIS; CNRS (UMR 5220); INSERM (U1044); INSA Lyon; Université de Lyon, Lyon, France.
authors: Benedicte M A
authors: BM
authors: Delattre
authors: CREATIS; CNRS (UMR 5220); INSERM (U1044); INSA Lyon; Université de Lyon, Lyon, France.
authors: Hongjiang
authors: H
authors: Wei
authors: Siemens Healthcare France, Saint-Denis, France.
authors: Benjamin
authors: B
authors: Robert
authors: CREATIS; CNRS (UMR 5220); INSERM (U1044); INSA Lyon; Université de Lyon, Lyon, France.
authors: Olivier
authors: O
authors: Beuf
authors: CREATIS; CNRS (UMR 5220); INSERM (U1044); INSA Lyon; Université de Lyon, Lyon, France.|Department of Radiology, Centre Hospitalier Universitaire de Saint-Etienne, Université Jean-Monnet, France.
authors: Magalie
authors: M
authors: Viallon
mesh_terms: D000328:Adult; D000465:Algorithms; D016477:Artifacts; D003199:Computer Systems; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
keywords: DTI; IVIM; diffusion; free-breathing; heart; slice following