title: Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity.
abstract: A newly discovered B cell subset, age-associated B cells, expresses the transcription factor T-bet, has a unique surface phenotype, and accumulates progressively with age. Moreover, B cells with these general features are associated with viral infections and autoimmunity in both mice and humans. In this article, we review current understanding of the characteristics, origins, and functions of these cells. We also suggest that the protective versus pathogenic actions of these cells reflect appropriate versus aberrant engagement of regulatory mechanisms that control the Ab responses to nucleic acid-containing Ags.
authors: Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; Department of Biomedical Science, National Jewish Health, Denver, CO 80206; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045; rubtsovak@njhealth.org.
authors: Kira
authors: K
authors: Rubtsova
authors: Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; Department of Biomedical Science, National Jewish Health, Denver, CO 80206; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045;
authors: Anatoly V
authors: AV
authors: Rubtsov
authors: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;
authors: Michael P
authors: MP
authors: Cancro
authors: Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; Department of Biomedical Science, National Jewish Health, Denver, CO 80206; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045; Department of Medicine, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045; and Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045.
authors: Philippa
authors: P
authors: Marrack
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology; D020825:T-Box Domain Proteins / Q000276:immunology* / Q000378:metabolism; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor