title: Intraocular myofibroblastoma in an infant: a case report.
abstract: BACKGROUND
  Myofibroblastoma is a benign tumor composed of spindle cells and bands of hyalinized collagen. Intraocular myofibroblastoma in infancy is rarely encountered.
  
  
  METHODS
  The present study reports the case of a 4-month-old female baby with intraocular myofibroblastoma. She was suspected as corneal perforation due to the rupture of a corneal neoplasm in the right eye. The anterior segment was also involved according to the Color Doppler ultrasonography. A surgical exploration was performed and the protuberant part of the mass was resected. Conventional HE staining showed numerous spindle-shaped cells with bands of collagen beneath multilayers of well-differentiated corneal epithelia. Immunohistochemical staining demonstrated the tumor cells were strong positive for vimentin and smooth muscle actin, while negative for S-100 protein. The mass was confirmed as myofibroblastoma. After 12 month follow-up, there was no apparent growth of the tumor.
  
  
  CONCLUSIONS
  Myofibroblastoma is a very rare type of intraocular neoplasm, which may have complicated manifestation and could be misdiagnosed as dermoid or Peter's anomaly. Histopathological and immunohistochemical staining is crucial to form a precise diagnosis.
authors: Tianjin Medical University Eye Hospital, Tianjin, China. 0133_cn@sina.com.
authors: Ning
authors: N
authors: Hua
authors: Tianjin Eye Hospital, Tianjin, China. ykyylin@126.com.
authors: Jinyong
authors: J
authors: Lin
authors: Tianjin Medical University Eye Hospital, Tianjin, China. qianjohn@163.com.
authors: Xuehan
authors: X
authors: Qian
authors: Tianjin Medical University Eye Hospital, Tianjin, China. dr.weinan@hotmail.com.
authors: Nan
authors: N
authors: Wei
authors: Tianjin Medical University Eye Hospital, Tianjin, China. zhaosz1997@sina.com.
authors: Shaozhen
authors: S
authors: Zhao
mesh_terms: D000199:Actins / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D003316:Corneal Diseases / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D009379:Neoplasms, Muscle Tissue / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism; D018615:Ultrasonography, Doppler, Color; D014746:Vimentin / Q000378:metabolism
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D015415:Biomarkers; D009418:S100 Proteins; D014746:Vimentin