title: Altered source memory retrieval is associated with pathological doubt in obsessive-compulsive disorder.
abstract: Individuals with obsessive-compulsive disorder (OCD) often complain of doubt related to memory. As neuropsychological research has demonstrated that individuals with OCD tend to focus on details and miss the larger context, the construct of source (contextual) memory may be particularly relevant to memory complaints in OCD. Memory for object versus contextual information relies on partially distinct regions within the prefrontal cortex, parietal and medial temporal lobe, and may be differentially impacted by OCD. In the present study, we sought to test the hypothesis that individuals with OCD exhibit impaired source memory retrieval using a novel memory paradigm - The Memory for Rooms Test (MFRT) - a four-room memory task in which participants walk through four rooms and attempt to encode and remember objects. Demographically matched individuals with OCD and healthy controls studied objects in the context of four rooms, and then completed a memory retrieval test while undergoing functional magnetic resonance imaging (fMRI). While no differences were observed in source memory accuracy, individuals with OCD exhibited greater task related activation in the posterior cingulate cortex (PCC) relative to healthy controls during correct source memory retrieval. During correct object recognition, individuals with OCD failed to recruit the dorsolateral prefrontal(DLPFC)/premotor, left mPFC, and right parietal regions to the same extent as healthy controls. Our results suggest abnormal recruitment of frontal-parietal and PCC regions during source verses object memory retrieval in OCD. Within the OCD group, activation in the PCC and the premotor/DLPFC was associated with greater pathological doubt. This finding is consistent with the observation that OCD patients often experience extreme doubt, even when memory performance is intact.
authors: Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, KS, United States; Department of Psychiatry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, United States. Electronic address: colson22@wisc.edu.
authors: Christy A
authors: CA
authors: Olson
authors: Kansas City Center for Anxiety Treatment, Overland Park, KS, United States.
authors: Lisa R
authors: LR
authors: Hale
authors: Department of Psychology, University of Kansas, Lawrence, KS, United States.
authors: Nancy
authors: N
authors: Hamilton
authors: Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, KS, United States.
authors: Joshua N
authors: JN
authors: Powell
authors: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States.
authors: Laura E
authors: LE
authors: Martin
authors: Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, KS, United States.
authors: Cary R
authors: CR
authors: Savage
mesh_terms: D000328:Adult; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology*; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000503:physiopathology*; D010296:Parietal Lobe / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D021641:Recognition, Psychology / Q000502:physiology*
keywords: Anxiety; Memory; Neuroimaging; Obsessive–compulsive disorder; Source; fMRI