title: OCT angiography by absolute intensity difference applied to normal and diseased human retinas.
abstract: We compare four optical coherence tomography techniques for noninvasive visualization of microcapillary network in the human retina and murine cortex. We perform phantom studies to investigate contrast-to-noise ratio for angiographic images obtained with each of the algorithm. We show that the computationally simplest absolute intensity difference angiographic OCT algorithm that bases only on two cross-sectional intensity images may be successfully used in clinical study of healthy eyes and eyes with diabetic maculopathy and branch retinal vein occlusion.
authors: Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Grudziadzka 5, 87-100 Torun, Poland ; both authors contributed equally.
authors: Daniel
authors: D
authors: Ruminski
authors: Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Grudziadzka 5, 87-100 Torun, Poland ; Department of Ophthalmology, Nicolaus Copernicus University, 9 M. Sklodowskiej-Curie St., 85-094 Bydgoszcz, Poland ; both authors contributed equally.
authors: Bartosz L
authors: BL
authors: Sikorski
authors: Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Grudziadzka 5, 87-100 Torun, Poland.
authors: Danuta
authors: D
authors: Bukowska
authors: Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Grudziadzka 5, 87-100 Torun, Poland.
authors: Maciej
authors: M
authors: Szkulmowski
authors: Laboratory of Intelligent Decision Support Systems, Poznan University of Technology, Piotrowo 2, 60-965 Poznań, Poland.
authors: Krzysztof
authors: K
authors: Krawiec
authors: Department of Ophthalmology, Nicolaus Copernicus University, 9 M. Sklodowskiej-Curie St., 85-094 Bydgoszcz, Poland.
authors: Grazyna
authors: G
authors: Malukiewicz
authors: Collegium Medicum, Nicolaus Copernicus University in Torun, Jagiellońska 13-15, 85-067 Bydgoszcz, Poland.
authors: Lech
authors: L
authors: Bieganowski
authors: Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Grudziadzka 5, 87-100 Torun, Poland.
authors: Maciej
authors: M
authors: Wojtkowski
keywords: (110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging; (170.4470) Ophthalmology; (280.2490) Flow diagnostics