title: Certification of Total Arsenic in Blood and Urine Standard Reference Materials by Radiochemical Neutron Activation Analysis and Inductively Coupled Plasma - Mass Spectrometry.
abstract: A newly developed procedure for determination of arsenic by radiochemical neutron activation analysis (RNAA) was used to measure arsenic at four levels in SRM 955c Toxic Elements in Caprine Blood and at two levels in SRM 2668 Toxic Elements in Frozen Human Urine for the purpose of providing mass concentration values for certification. Samples were freeze-dried prior to analysis followed by neutron irradiation for 3 h at a fluence rate of 1×1014cm-2s-1. After sample dissolution in perchloric and nitric acids, arsenic was separated from the matrix by extraction into zinc diethyldithiocarbamate in chloroform, and76As quantified by gamma-ray spectroscopy. Differences in chemical yield and counting geometry between samples and standards were monitored by measuring the count rate of a77As tracer added before sample dissolution. RNAA results were combined with inductively coupled plasma - mass spectrometry (ICP-MS) values from NIST and collaborating laboratories to provide certified values of (10.81 ± 0.54) μg/kg and (213.1 ± 0.73) μg/kg for SRM 2668 Levels I and II, and certified values of (21.66 ± 0.73) μg/kg, (52.7 ± 1.1) μg/kg, and (78.8 ± 4.9) μg/kg for SRM 955c Levels 2, 3, and 4 respectively. Because of discrepancies between values obtained by different methods for SRM 955c Level 1, an information value of < 5 μg/kg was assigned for this material.
authors: Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899.
authors: Rick L
authors: RL
authors: Paul
authors: Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899.
authors: W Clay
authors: WC
authors: Davis
authors: Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899.
authors: Lee
authors: L
authors: Yu
authors: Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899.
authors: Karen E
authors: KE
authors: Murphy
authors: Statistical Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD 20899.
authors: William F
authors: WF
authors: Guthrie
authors: Statistical Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD 20899.
authors: Dennis D
authors: DD
authors: Leber
authors: Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899.
authors: Colleen E
authors: CE
authors: Bryan
authors: Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899.
authors: Thomas W
authors: TW
authors: Vetter
authors: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30341.
authors: Gulchekhra
authors: G
authors: Shakirova
authors: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30341.
authors: Graylin
authors: G
authors: Mitchell
authors: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30341.
authors: David J
authors: DJ
authors: Kyle
authors: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30341.
authors: Jeffery M
authors: JM
authors: Jarrett
authors: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30341.
authors: Kathleen L
authors: KL
authors: Caldwell
authors: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30341.
authors: Robert L
authors: RL
authors: Jones
authors: Mayo Clinic, Rochester, MN 55905.
authors: Steven
authors: S
authors: Eckdahl
authors: Mayo Clinic, Rochester, MN 55905.
authors: Michelle
authors: M
authors: Wermers
authors: Mayo Clinic, Rochester, MN 55905.
authors: Melissa
authors: M
authors: Maras
authors: Laboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health (NYSDOH), Albany, NY 12201-0509.
authors: C D
authors: CD
authors: Palmer
authors: Laboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health (NYSDOH), Albany, NY 12201-0509.
authors: M F
authors: MF
authors: Verostek
authors: Laboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health (NYSDOH), Albany, NY 12201-0509.
authors: C M
authors: CM
authors: Geraghty
authors: Laboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health (NYSDOH), Albany, NY 12201-0509.
authors: Amy J
authors: AJ
authors: Steuerwald
authors: Laboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health (NYSDOH), Albany, NY 12201-0509 ; Dept of Environmental Health Sciences, School of Public Health, University at Albany, 12201-0509.
authors: Patrick J
authors: PJ
authors: Parsons
keywords: arsenic; biologicals; neutron activation analysis; radiochemistry; standard reference materials; toxic elements