title: Selective Expression of Galanin in Neuronal-Like Cells of the Human Carotid Body.
abstract: The carotid body is a neural-crest-derived organ devoted to respiratory homeostasis through sensing changes in blood oxygen levels. The sensory units are the glomeruli composed of clusters of neuronal-like (type I) cells surrounded by glial-like (type II) cells. During chronic hypoxia, the carotid body shows growth, with increasing neuronal-like cell numbers. We are interested in the signals involved in the mechanisms that underlie such response, because they are not well understood and described. Considering that, in literature, galanin is involved in neurotrophic or neuroprotective role in cell proliferation and is expressed in animal carotid body, we investigated its expression in human. Here, we have shown the expression and localisation of galanin in the human carotid body.
authors: Department of Neurosciences, Imaging and Clinical Science, University 'G. d'Annunzio' of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy.
authors: Camillo
authors: C
authors: Di Giulio
authors: Guya Diletta
authors: GD
authors: Marconi
authors: Susi
authors: S
authors: Zara
authors: Andrea
authors: A
authors: Di Tano
authors: Andrea
authors: A
authors: Porzionato
authors: Mieczyslaw
authors: M
authors: Pokorski
authors: Amelia
authors: A
authors: Cataldi
authors: Andrea
authors: A
authors: Mazzatenta
mesh_terms: D000328:Adult; D000368:Aged; D002344:Carotid Body / Q000737:chemistry* / Q000166:cytology / Q000502:physiology; D019004:Galanin / Q000032:analysis* / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry*
chemical_list: D019004:Galanin