title: A new device for the prevention of pulmonary embolism in critically ill patients: Results of the European Angel Catheter Registry.
abstract: BACKGROUND
  Pulmonary embolism (PE) is a potentially life-threatening complication of critical illness. In trauma and neurosurgical patients with contraindications to anticoagulation, inferior vena cava (IVC) filters have been used to prevent PE, but their associated long-term complication rates and difficulties associated with filter removal have limited their use. The Angel catheter is a temporary device, which combined an IVC filter with a triple-lumen central venous catheter (IVC filter-catheter) and is intended for bedside placement and removal when no longer indicated.
  
  
  METHODS
  This study presents data from a European Registry of 60 critically ill patients in whom the IVC filter-catheter was used to prevent PE. The patients were all at high risk of PE development or recurrence and had contraindications to anticoagulation. The primary end points of this study were to evaluate the safety (in particular, the presence of infectious or thrombotic events) and effectiveness (the numbers of PEs and averted PEs) of the IVC filter-catheter.
  
  
  RESULTS
  The main diagnosis before catheter insertion was major trauma in 33 patients (55%), intracerebral hemorrhage or stroke in 9 (15%), a venous thromboembolic event in 9 (15%), and active bleeding in 6 (10%). The IVC filter-catheter was placed as prophylaxis in 51 patients (85%) and as treatment in the 9 patients (15%) with venous thromboembolic event. The devices were inserted at the bedside without fluoroscopic guidance in 54 patients (90%) and within a median of 4 days after hospital admission. They were left in place for a mean of 6 days (4-8 days). One patient developed a PE, without hemodynamic compromise; two PEs were averted. No serious adverse events were reported.
  
  
  CONCLUSIONS
  Early bedside placement of an IVC filter-catheter is possible, and our results suggest that this is a safe, effective alternative to short-term PE prophylaxis for high-risk patients with contraindications to anticoagulation.
  
  
  METHODS
  Therapeutic study, level V.
authors: From the Department of Intensive Care (F.S.T., D.D.B., J.-L.V.), Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium; Anaesthesia and Intensive Care Medicine (N.B., K.B.), Barts Health Royal, London Hospital, London; Department of Intensive Care (C.W.), Royal Berkshire Hospital, Berkshire; and Department of Interventional Radiology (R.G.J.), Queen Elizabeth Hospital, Birmingham, United Kingdom; Department of Anesthesiology and Intensive Care (W.S.), University Hospital, Krakow, Poland.
authors: Fabio S
authors: FS
authors: Taccone
authors: Nicholas
authors: N
authors: Bunker
authors: Carl
authors: C
authors: Waldmann
authors: Daniel
authors: D
authors: De Backer
authors: Karim
authors: K
authors: Brohi
authors: Robert G
authors: RG
authors: Jones
authors: Jean-Louis
authors: JL
authors: Vincent
mesh_terms: D000328:Adult; D000497:Alloys; D002405:Catheterization, Central Venous; D016638:Critical Illness; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000517:prevention & control*; D012042:Registries; D012307:Risk Factors; D016896:Treatment Outcome; D016306:Vena Cava Filters
chemical_list: D000497:Alloys; C013616:nitinol