title: Analysis of Expression of Vascular Endothelial Growth Factor A and Hypoxia Inducible Factor-1alpha in Patients Operated on Stage I Non-Small-Cell Lung Cancer.
abstract: Objectives. Recent studies show that expression of hypoxia inducible factor-1alpha (HIF-1α) favours expression of vascular endothelial growth factor A (VEGF-A), and these biomarkers are linked to cellular proliferation, angiogenesis, and metastasis in different cancers. We analyze expression of HIF-1α and VEGF-A to clinicopathologic features and survival of patients operated on stage I non-small-cell lung cancer. Methodology. Prospective study of 52 patients operated on with stage I. Expression of VEGF-A and HIF-1α was performed through real-time quantitative polymerase chain reaction (qRT-PCR). Results. Mean age was 64.7 and 86.5% of patients were male. Stage IA represented 23.1% and stage IB 76.9%. Histology classification was 42.3% adenocarcinoma, 34.6% squamous cell carcinoma, and 23.1% others. Median survival was 81.0 months and 5-year survival 67.2%. There was correlation between HIF-1α and VEGF-A (P = 0.016). Patients with overexpression of HIF-1α had a tendency to better survival with marginal statistical significance (P = 0.062). Patients with overexpression of VEGF-A had worse survival, but not statistically significant (P = 0.133). Conclusion. The present study revealed that VEGF-A showed correlation with HIF-1α. HIF-1α had a tendency to protective effect with a P value close to statistical significance. VEGF-A showed a contrary effect but without statistical significance.
authors: Thoracic Surgery, University General Hospital of Albacete, 37 Hermanos Falcó Street, 02006 Albacete, Spain.
authors: Antonio Francisco
authors: AF
authors: Honguero Martínez
authors: Thoracic Surgery, University General Hospital of Valencia and Surgery Department of the School of Medicine and Odontology, University of Valencia, 15 Blasco Ibáñez Avenue, 46010 Valencia, Spain.
authors: Antonio
authors: A
authors: Arnau Obrer
authors: Thoracic Surgery, University General Hospital of Valencia, Tres Creus Avenue, 46014 Valencia, Spain.
authors: Santiago
authors: S
authors: Figueroa Almánzar
authors: Thoracic Surgery, University General Hospital of Albacete, 37 Hermanos Falcó Street, 02006 Albacete, Spain.
authors: Pablo
authors: P
authors: León Atance
authors: Thoracic Surgery, University General Hospital of Valencia and Surgery Department of the School of Medicine and Odontology, University of Valencia, 15 Blasco Ibáñez Avenue, 46010 Valencia, Spain.
authors: Ricardo
authors: R
authors: Guijarro Jorge