title: Synthesis and Characterization of Magnetic Polyvinyl Alcohol (PVA) Hydrogel Microspheres for the Embolization of Blood Vessel.
abstract: OBJECTIVE
  Vascular embolization has exhibited increasing significance in treatment of terminal cancer. In order to achieve better embolic effects, magnetic polyvinyl alcohol hydrogel microspheres were synthesized for magnetic field-controlled vascular embolization.
  
  
  METHODS
  Inverse suspension crosslinking method was adopted to synthesize the magnetic hydrogel microspheres by loading magnetic nanoparticles inside. The magnetic property, CT angiography, drug release, and magnetothermal performance were characterized in vitro, respectively. The fluidity of microspheres was also showed by simulation and experiment in vitro.
  
  
  RESULTS
  The microspheres were shown to have capability of drug loading, CT imaging, and magnetothermal behavior. Both the simulated and the experimental results exhibited that the microspheres can be controlled to aggregate in the fluid in the presence of magnetic field.
  
  
  CONCLUSIONS
  The magnetic hydrogel microspheres exhibited the specific fluidity-like iodized oil, but were able to form solid embolus. Because of the advantages of this novel material, it is expected to get extensive application in the clinic embolotherapy.
authors: Shuang
authors: S
authors: Qiu
authors: Nai J
authors: NJ
authors: Ge
authors: Dong K
authors: DK
authors: Sun
authors: Sheng
authors: S
authors: Zhao
authors: Jian F
authors: JF
authors: Sun
authors: Zhao B
authors: ZB
authors: Guo
authors: Ke
authors: K
authors: Hu
authors: Ning
authors: N
authors: Gu
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply; D004621:Embolization, Therapeutic / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D008863:Microspheres; D011142:Polyvinyl Alcohol / Q000737:chemistry*
chemical_list: D058185:Magnetite Nanoparticles; C062364:polyvinyl alcohol hydrogel; D011142:Polyvinyl Alcohol