title: Clinical risk factors associated with the development of wheezing in children less than 2 years of age who required hospitalization for viral lower respiratory tract infections.
abstract: OBJECTIVE
  Wheezing following viral lower respiratory tract infections (LRTIs) in children <2 years of age is an important risk factor for the development of asthma later in life; however, not all children with viral LRTIs develop wheezing. This study investigated risk factors for the development of wheezing during viral LRTIs requiring hospitalization.
  
  
  METHODS
  The study included 142 children <2 years of age hospitalized for LRTIs with at least one virus identified as the cause and classified them into children diagnosed with LRTIs with wheezing (n=70) and those diagnosed with LRTIs without wheezing (n=72).
  
  
  RESULTS
  There were no significant differences in the viruses detected between the two groups. Multivariate logistic regression analysis showed that, after adjusting for potentially confounding variables including sex and age, the development of wheezing was strongly associated with parental history of allergic diseases (adjusted odds ratio [aOR], 20.19; 95% confidence interval [CI], 3.22-126.48), past history of allergic diseases (aOR, 13.95; 95% CI, 1.34-145.06), past history of hospitalization for respiratory illnesses (aOR, 21.36; 95% CI, 3.77-120.88), exposure to secondhand smoke at home (aOR, 14.45; 95% CI, 4.74-44.07), and total eosinophil count (aOR, 1.01; 95% CI, 1.01-1.02).
  
  
  CONCLUSIONS
  Past and parental history of allergic diseases, past history of hospitalization for respiratory illnesses, exposure to secondhand smoke at home, and total eosinophil count were closely associated with the development of wheezing in children <2 years of age who required hospitalization for viral LRTIs. Clinicians should take these factors into consideration when treating, counseling, and monitoring young children admitted for viral LRTIs.
authors: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea.
authors: Joon Hwan
authors: JH
authors: Kim
authors: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea.
authors: Ji-Yeon
authors: JY
authors: Choi
authors: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea.
authors: Na Yeon
authors: NY
authors: Kim
authors: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea.
authors: Jin Woo
authors: JW
authors: Kim
authors: Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
authors: Ji Hyeon
authors: JH
authors: Baek
authors: Department of Pediatrics, Hallym University Kandong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors: Hye Sung
authors: HS
authors: Baek
authors: Department of Pediatrics, Myongji Hospital, Goyang, Korea.
authors: Jung Won
authors: JW
authors: Yoon
authors: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea. ; CHA University School of Medicine, Pocheon, Korea.
authors: Hye Mi
authors: HM
authors: Jee
authors: Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.
authors: Sun Hee
authors: SH
authors: Choi
authors: Department of Pediatrics, Bundang Jesaeng Hospital, Seongnam, Korea.
authors: Hyeung Yoon
authors: HY
authors: Kim
authors: CHA University School of Medicine, Pocheon, Korea. ; Department of Pediatrics, CHA Gangnam Medical Center, Seoul, Korea.
authors: Ki Eun
authors: KE
authors: Kim
authors: CHA University School of Medicine, Pocheon, Korea. ; Department of Pediatrics, CHA Gangnam Medical Center, Seoul, Korea.
authors: Youn Ho
authors: YH
authors: Shin
authors: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea. ; CHA University School of Medicine, Pocheon, Korea.
authors: Man Yong
authors: MY
authors: Han
keywords: Respiratory tract infections; Risk factors; Viruses; Wheezing