title: [Sequence Analysis of A Novel HLA-B*13:68 Allele].
abstract: OBJECTIVE
  The purpose of this research was to identify a novel HLA-B allele in Chinese population.
  
  
  METHODS
  The HLA typing of bone marrow donors was performed by PCR-SBT. The ambiguous novel HLA allele was confirmed with GSSP method.
  
  
  RESULTS
  The sequence of a sample was different from all alleles in the HLA-B databases. The sequence analysis showed that it differed from the closet matching allele HLA-B*13:01:01 at one nucleotide substitution, 137 T > C in Exon2, which resulted in an amino acid change from Phenylalanine (Phe) to Serine (Ser) at codon 22.
  
  
  CONCLUSIONS
  A novel allele was identified and named as HLA-B*13:68 by the WHO Nomenclature Committee.
authors: Institute of Transfusion Medicine, Qingdao Blood Center, Qingdao 266071, Shandong Province, China.
authors: Bin
authors: B
authors: Han
authors: Institute of Transfusion Medicine, Qingdao Blood Center, Qingdao 266071, Shandong Province, China.
authors: Li
authors: L
authors: Han
authors: Institute of Transfusion Medicine, Qingdao Blood Center, Qingdao 266071, Shandong Province, China.
authors: Zhi-Hui
authors: ZH
authors: Feng
authors: Institute of Transfusion Medicine, Qingdao Blood Center, Qingdao 266071, Shandong Province, China.
authors: Xiao-Yun
authors: XY
authors: Chi
authors: Institute of Transfusion Medicine, Qingdao Blood Center, Qingdao 266071, Shandong Province, China . E-mail: qd_hla@sina.com.
authors: Shu-Xian
authors: SX
authors: Jiao
mesh_terms: D000483:Alleles; D044466:Asian People; D001483:Base Sequence; D015235:HLA-B Antigens; D006650:Histocompatibility Testing; D006801:Humans; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D015235:HLA-B Antigens