title: Biotransformation of (-)-epicatechin, (+)-epicatechin, (-)-catechin, and (+)-catechin by intestinal bacteria involved in isoflavone metabolism.
abstract: Isoflavone-metabolizing bacteria, Adlercreutzia equolifaciens, Asaccharobacter celatus, Slackia equolifaciens, and Slackia isoflavoniconvertens catalyzed C-ring cleavage of (-)-epicatechin and (+)-catechin, (+)-epicatechin, and (-)-catechin in varying degrees. The cleaving abilities of (-)-epicatechin and (+)-catechin were enhanced by hydrogen, except (+)-catechin cleavage by S. equolifaciens, which was not accelerated. (-)-Catechin cleavage by Ad. equolifaciens was remarkably accelerated by hydrogen.
authors: a Food Research Laboratories , Mitsui Norin Co., Ltd. , Fujieda , Japan.
authors: Akiko
authors: A
authors: Takagaki
authors: a Food Research Laboratories , Mitsui Norin Co., Ltd. , Fujieda , Japan.
authors: Fumio
authors: F
authors: Nanjo
mesh_terms: D039903:Actinobacteria / Q000187:drug effects / Q000378:metabolism*; D001711:Biotransformation; D002392:Catechin / Q000378:metabolism*; D006859:Hydrogen / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D006859:Hydrogen; D002392:Catechin
keywords: bacteria; catechin; degradation; isoflavone; metabolite