title: Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity.
abstract: Most age-related diseases and aging itself are associated with chronic inflammation. Thus pharmacological inhibition of inflammatory processes may be effective antiaging strategy. In this study we demonstrated that treatment of Drosophila melanogaster with 10 non-steroidal anti-inflammatory drugs (NSAIDs: CAY10404, aspirin, APHS, SC-560, NS-398, SC-58125, valeroyl salicylate, trans-resveratrol, valdecoxib, licofelone) leads to extension of lifespan, delays age-dependent decline of locomotor activity and increases stress resistance. The effect of the lifespan increase was associated with decrease of fecundity. Depending on the concentration, NSAIDs demonstrated both anti- and pro-oxidant properties in Drosophila tissues. However, we failed to identify clear correlation between antioxidant properties of NSAIDs and their pro-longevity effects. The lifespan extending effects of APHS, SC-58125, valeroyl salicylate, trans-resveratrol, valdecoxib, and licofelone were more pronounced in males, valdecoxib and aspirin - in females. We demonstrated that lifespan extension effect of NSAIDs was abolished in flies with defective genes involved in Pkh2-ypk1-lem3-tat2 pathway.
authors: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.|Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia.
authors: Anton
authors: A
authors: Danilov
authors: Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia.|Syktyvkar State University, Syktyvkar, Russia.
authors: Mikhail
authors: M
authors: Shaposhnikov
authors: Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia.
authors: Oksana
authors: O
authors: Shevchenko
authors: Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia.
authors: Nadezhda
authors: N
authors: Zemskaya
authors: Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
authors: Alex
authors: A
authors: Zhavoronkov
authors: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.|Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia.|Syktyvkar State University, Syktyvkar, Russia.|Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
authors: Alexey
authors: A
authors: Moskalev
mesh_terms: D064413:3-Phosphoinositide-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism; D026905:Amino Acid Transport Systems / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000187:drug effects; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008136:Longevity / Q000187:drug effects*; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D012737:Sex Factors; D015398:Signal Transduction / Q000187:drug effects; D013997:Time Factors
chemical_list: D026905:Amino Acid Transport Systems; D000894:Anti-Inflammatory Agents, Non-Steroidal; D029721:Drosophila Proteins; D026901:Membrane Transport Proteins; D064413:3-Phosphoinositide-Dependent Protein Kinases; D038362:Glycogen Synthase Kinase 3
keywords: Drosophila; Geotarget; anti-inflammatory drugs; geroprotector; lifespan; longevity