title: [Pharmacological aspects of pain research in Germany].
abstract: In spite of several approved analgesics, the therapy of pain still constitutes a challenge due to the fact that the drugs do not exert sufficient efficacy or are associated with severe side effects. Therefore, the development of new and improved painkillers is still of great importance. A number of highly qualified scientists in Germany are investigating signal transduction pathways in pain, effectivity of new drugs and the so far incompletely investigated mechanisms of well-known analgesics in preclinical and clinical studies. The highlights of pharmacological pain research in Germany are summarized in this article.
authors: pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland.
authors: E
authors: E
authors: Niederberger
authors: Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 584, 69120, Heidelberg, Deutschland.
authors: R
authors: R
authors: Kuner
authors: pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland. geisslinger@em.uni-frankfurt.de.
authors: G
authors: G
authors: Geißlinger
mesh_terms: D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D015220:Calcium Channels / Q000502:physiology; D002490:Central Nervous System / Q000187:drug effects; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D009415:Nerve Net / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000502:physiology; D009437:Neuralgia / Q000188:drug therapy; D009473:Neuronal Plasticity / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D000074025:TRPA1 Cation Channel; D050051:Transient Receptor Potential Channels / Q000502:physiology; D057170:Translational Research, Biomedical; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015220:Calcium Channels; D007473:Ion Channels; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050051:Transient Receptor Potential Channels
keywords: Analgesics; Anti-inflammatory agents, non-steroidal; Ion channels; Neurotransmitters; Opioids