title: Branching of poly(ADP-ribose): Synthesis of the Core Motif.
abstract: The synthesis of the core motif of branched poly(adenosine diphosphate ribose) (poly(ADPr)) is described, and structural analysis reasserted the proposed stereochemistry for branching. For the synthesis, a ribose trisaccharide was first constructed with only α-O-glycosidic linkages. Finally, the adenine nucleobase was introduced via a Vorbrüggen-type glycosylation reaction. The orthogonality of the selected protecting groups was demonstrated, allowing for the construction of branched poly(ADPr) oligomers in the near future.
authors: Leiden Institute of Chemistry, Leiden University , P.O. Box 9502, 2300 RA Leiden, The Netherlands.
authors: Hans A V
authors: HA
authors: Kistemaker
authors: Leiden Institute of Chemistry, Leiden University , P.O. Box 9502, 2300 RA Leiden, The Netherlands.
authors: Herman S
authors: HS
authors: Overkleeft
authors: Leiden Institute of Chemistry, Leiden University , P.O. Box 9502, 2300 RA Leiden, The Netherlands.
authors: Gijsbert A
authors: GA
authors: van der Marel
authors: Leiden Institute of Chemistry, Leiden University , P.O. Box 9502, 2300 RA Leiden, The Netherlands.
authors: Dmitri V
authors: DV
authors: Filippov
mesh_terms: D006031:Glycosylation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011064:Poly Adenosine Diphosphate Ribose / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011064:Poly Adenosine Diphosphate Ribose