title: Canine rotavirus C strain detected in Hungary shows marked genotype diversity.
abstract: Species C rotaviruses (RVC) have been identified in humans and animals, including pigs, cows and ferrets. In dogs, RVC strains have been reported anecdotally on the basis of visualization of rotavirus-like virions by electron microscopy combined with specific electrophoretic migration patterns of the genomic RNA segments. However, no further molecular characterization of these viruses was performed. Here, we report the detection of a canine RVC in the stool of a dog with enteritis. Analysis of the complete viral genome uncovered distinctive genetic features of the identified RVC strain. The genes encoding VP7, VP4 and VP6 were distantly related to those of other RVC strains and were putatively classified as G10, P8 and I8, respectively. The new strain was named RVC/Dog-wt/HUN/KE174/2012/G10P[8]. Phylogenetic analyses revealed that canine RVC was most closely related to bovine RVC strains with the exception of the NSP4 gene, which clustered together with porcine RVC strains. These findings provide further evidence for the genetic diversity of RVC strains.
authors: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest 1143, Hungary.
authors: Szilvia
authors: S
authors: Marton
authors: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest 1143, Hungary.
authors: Eszter
authors: E
authors: Mihalov-Kovács
authors: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest 1143, Hungary.
authors: Renáta
authors: R
authors: Dóró
authors: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest 1143, Hungary.
authors: Tünde
authors: T
authors: Csata
authors: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest 1143, Hungary.
authors: Enikő
authors: E
authors: Fehér
authors: Virological Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.|Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.
authors: Miklós
authors: M
authors: Oldal
authors: Virological Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.|Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.
authors: Ferenc
authors: F
authors: Jakab
authors: KU Leuven-University of Leuven, Department of Microbiology and Immunology, Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, B-3000 Leuven, Belgium.
authors: Jelle
authors: J
authors: Matthijnssens
authors: Department of Veterinary Public Health, University of Bari, S.p. per Casamassima km 3, 70010 Valenzano, Bari, Italy.
authors: Vito
authors: V
authors: Martella
authors: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest 1143, Hungary.
authors: Krisztián
authors: K
authors: Bányai
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D004751:Enteritis / Q000662:veterinary* / Q000821:virology; D005243:Feces / Q000821:virology; D016679:Genome, Viral; D005838:Genotype; D006814:Hungary; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000662:veterinary* / Q000821:virology; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D012367:RNA, Viral