title: Increase in [18F]-Fluoroacetate Uptake in Patients With Chronic Hemodynamic Cerebral Ischemia.
abstract: OBJECTIVE
  [18F]-fluoroacetate ((18)F-FACE) can be used for evaluating glial cell metabolism. Experimental studies have shown an increase in (18)F-FACE uptake in rodent models of cerebral ischemia. The aim of this study was to determine whether (18)F-FACE uptake is increased in the noninfarcted cerebral cortex in patients with hemodynamic ischemia owing to atherosclerotic internal carotid artery or middle cerebral artery disease.
  
  
  METHODS
  We evaluated 9 symptomatic patients with unilateral atherosclerotic internal carotid artery or middle cerebral artery disease and no cortical infarction using positron emission tomography with (18)F-FACE and (15)O-gases. (18)F-FACE uptake during 40 to 60 minutes after injection was compared with the cerebral blood flow, cerebral metabolic rate of oxygen, oxygen extraction fraction, and cerebral blood volume in the middle cerebral artery distributions.
  
  
  RESULTS
  Significant decreases of cerebral blood flow and cerebral metabolic rate of oxygen and increases of oxygen extraction fraction and cerebral blood volume were found in the hemisphere ipsilateral to the arterial lesion, and (18)F-FACE uptake in this region was greater than that in the contralateral hemisphere. The relative (18)F-FACE uptake (ipsilateral/contralateral ratio) was negatively correlated with cerebral blood flow or cerebral metabolic rate of oxygen values and was positively correlated with oxygen extraction fraction values. Multivariate analysis showed that the ipsilateral/contralateral (18)F-FACE uptake ratio was independently correlated with the cerebral blood flow (or oxygen extraction fraction) and cerebral metabolic rate of oxygen values.
  
  
  CONCLUSIONS
  In patients with atherosclerotic internal carotid artery or middle cerebral artery disease, (18)F-FACE uptake is increased in the noninfarcted cerebral cortex with chronic hemodynamic ischemia characterized by misery perfusion with decreased oxygen metabolism. Increased (18)F-FACE uptake may indicate the cortical regions that are at particular risk for ischemic damage.
authors: From the Division of PET Imaging, Shiga Medical Centre Research Institute, Moriyama, Japan (H.Y., S.K., Y.K., M.T., T.H.); Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (R.N.); and Bio-Function Imaging Team (H.M., H.O.) and Clinical Application Unit (K.T.), RIKEN Center for Life Science Technologies, Kobe, Japan. yamauchi@res.med.shiga-pref.jp.
authors: Hiroshi
authors: H
authors: Yamauchi
authors: From the Division of PET Imaging, Shiga Medical Centre Research Institute, Moriyama, Japan (H.Y., S.K., Y.K., M.T., T.H.); Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (R.N.); and Bio-Function Imaging Team (H.M., H.O.) and Clinical Application Unit (K.T.), RIKEN Center for Life Science Technologies, Kobe, Japan.
authors: Shinya
authors: S
authors: Kagawa
authors: From the Division of PET Imaging, Shiga Medical Centre Research Institute, Moriyama, Japan (H.Y., S.K., Y.K., M.T., T.H.); Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (R.N.); and Bio-Function Imaging Team (H.M., H.O.) and Clinical Application Unit (K.T.), RIKEN Center for Life Science Technologies, Kobe, Japan.
authors: Yoshihiko
authors: Y
authors: Kishibe
authors: From the Division of PET Imaging, Shiga Medical Centre Research Institute, Moriyama, Japan (H.Y., S.K., Y.K., M.T., T.H.); Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (R.N.); and Bio-Function Imaging Team (H.M., H.O.) and Clinical Application Unit (K.T.), RIKEN Center for Life Science Technologies, Kobe, Japan.
authors: Masaaki
authors: M
authors: Takahashi
authors: From the Division of PET Imaging, Shiga Medical Centre Research Institute, Moriyama, Japan (H.Y., S.K., Y.K., M.T., T.H.); Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (R.N.); and Bio-Function Imaging Team (H.M., H.O.) and Clinical Application Unit (K.T.), RIKEN Center for Life Science Technologies, Kobe, Japan.
authors: Ryuichi
authors: R
authors: Nishii
authors: From the Division of PET Imaging, Shiga Medical Centre Research Institute, Moriyama, Japan (H.Y., S.K., Y.K., M.T., T.H.); Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (R.N.); and Bio-Function Imaging Team (H.M., H.O.) and Clinical Application Unit (K.T.), RIKEN Center for Life Science Technologies, Kobe, Japan.
authors: Hiroshi
authors: H
authors: Mizuma
authors: From the Division of PET Imaging, Shiga Medical Centre Research Institute, Moriyama, Japan (H.Y., S.K., Y.K., M.T., T.H.); Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (R.N.); and Bio-Function Imaging Team (H.M., H.O.) and Clinical Application Unit (K.T.), RIKEN Center for Life Science Technologies, Kobe, Japan.
authors: Kazuhiro
authors: K
authors: Takahashi
authors: From the Division of PET Imaging, Shiga Medical Centre Research Institute, Moriyama, Japan (H.Y., S.K., Y.K., M.T., T.H.); Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (R.N.); and Bio-Function Imaging Team (H.M., H.O.) and Clinical Application Unit (K.T.), RIKEN Center for Life Science Technologies, Kobe, Japan.
authors: Hirotaka
authors: H
authors: Onoe
authors: From the Division of PET Imaging, Shiga Medical Centre Research Institute, Moriyama, Japan (H.Y., S.K., Y.K., M.T., T.H.); Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan (R.N.); and Bio-Function Imaging Team (H.M., H.O.) and Clinical Application Unit (K.T.), RIKEN Center for Life Science Technologies, Kobe, Japan.
authors: Tatsuya
authors: T
authors: Higashi
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000209:etiology; D002343:Carotid Artery, Internal / Q000473:pathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002908:Chronic Disease; D005260:Female; D005463:Fluoroacetates; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D005463:Fluoroacetates
keywords: carotid artery, internal; fluoroacetates; infarction; positron-emission tomography; stroke