title: Body weight gain in patients with bilateral deep brain stimulation for dystonia.
abstract: In patients with Parkinson's disease, significant weight gain following chronic deep brain stimulation (DBS) has been reported. Recently, relevant weight gain could be demonstrated also following subthalamic nucleus DBS in patients with primary cervical dystonia. Prospective analyses of body weight changes following DBS in patients with dystonia, however, have not been published so far. We aimed to analyse the changes of body weight following DBS in patients with dystonia. The body mass index (BMI) of 17 consecutive patients with segmental or generalised dystonia (mean age 54.6 ± 16.1 years) treated with bilateral DBS of the globus pallidus internus (GPi) (n = 14) or the thalamic ventral intermediate nucleus (n = 3) was measured preoperatively (pre-OP) and at three follow-up (FU) time points post-DBS surgery (FU1 = 7 months, FU2 = 17 months, FU3 = 72 months). All patients benefited from marked improvement in their dystonia. The mean BMI pre-OP (SD) was 22.5 (±3.7) kg/m(2) and increased stepwise to 24.0 (±3.3) kg/m(2) at FU1, 24.4 (±3.7) kg/m(2) at FU2 and 24.9 (±3.7) kg/m(2) at FU3 (p < 0.05 at all three FUs compared to pre-OP). Relative BMI increase and improvement of dystonia were correlated (p = 0.025). Chronic bilateral GPi DBS in patients with dystonia is associated with significant body weight gain, in particular during the first 6 months post-OP. This probably is a result of improvement of dystonic motor symptoms and recovery of eating dysfunction rather than a target-specific phenomenon.
authors: Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. wolf@neuro.ma.uni-heidelberg.de.
authors: Marc E
authors: http://orcid.org/0000-0002-7683-6918
authors: ME
authors: Wolf
authors: Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
authors: Hans-Holger
authors: HH
authors: Capelle
authors: Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
authors: Götz
authors: G
authors: Lütjens
authors: Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
authors: Anne D
authors: AD
authors: Ebert
authors: Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
authors: Michael G
authors: MG
authors: Hennerici
authors: Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
authors: Joachim K
authors: JK
authors: Krauss
authors: Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
authors: Christian
authors: C
authors: Blahak
mesh_terms: D000368:Aged; D015992:Body Mass Index; D046690:Deep Brain Stimulation; D004421:Dystonia / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015430:Weight Gain
keywords: Deep brain stimulation; Dystonia; Internal globus pallidus; Ventral intermediate nucleus; Weight change