title: Thromboinflammation in Therapeutic Medicine.
abstract: Thromboinflammation is primarily triggered by the humoral innate immune system, which mainly consists of the cascade systems of the blood, i.e., the complement, contact/coagulation and fibrinolytic systems. Activation of these systems subsequently induces activation of endothelial cells, leukocytes and platelets, finally resulting in thrombotic and inflammatory reactions. Such reactions are triggered by a number of medical procedures, e.g., treatment with biomaterials or drug delivery devices as well as in transplantation with cells, cell clusters or whole vascularized organs. Here, we (1) describe basic mechanisms for thromboinflammation; (2) review thromboinflammatory reactions in therapeutic medicine; and (3) discuss emerging strategies to dampen thromboinflammation.
authors: Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden, Kristina.Nilsson_Ekdahl@igp.uu.se.
authors: Kristina N
authors: KN
authors: Ekdahl
authors: Yuji
authors: Y
authors: Teramura
authors: Sana
authors: S
authors: Asif
authors: Nina
authors: N
authors: Jonsson
authors: Peetra U
authors: PU
authors: Magnusson
authors: Bo
authors: B
authors: Nilsson
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000009:adverse effects; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000276:immunology / Q000378:metabolism; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D056724:Immunity, Humoral / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007155:Immunologic Factors / Q000627:therapeutic use*; D007249:Inflammation / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D013927:Thrombosis / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D016378:Tissue Transplantation
chemical_list: D000925:Anticoagulants; D001672:Biocompatible Materials; D001779:Blood Coagulation Factors; D007155:Immunologic Factors; D003165:Complement System Proteins