title: Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors.
abstract: BACKGROUND
  Identifying the underlying cellular mechanisms of episodic memory is an important challenge, since this memory, based on temporal and contextual associations among events, undergoes preferential degradation in aging and various neuropsychiatric disorders. Memory storage of temporal and contextual associations is known to rely on hippocampal N-methyl-D-aspartate receptor (NMDAR)-dependent synaptic plasticity, which depends ex vivo on dynamic organization of surface NMDARs. Whether NMDAR surface trafficking sustains the formation of associative memory, however, remains unknown.
  
  
  METHODS
  We tested this hypothesis, using single nanoparticle imaging, electrophysiology, and behavioral approaches, in hippocampal networks challenged with a potent modulator of NMDAR-dependent synaptic plasticity and memory, 17β-estradiol (E2).
  
  
  RESULTS
  We demonstrate that E2 modulates NMDAR surface trafficking, a necessary condition for E2-induced potentiation at hippocampal cornu ammonis 1 synapses. Strikingly, cornu ammonis 1 NMDAR surface trafficking controls basal and E2-enhanced mnemonic retention of temporal, but not contextual, associations.
  
  
  CONCLUSIONS
  NMDAR surface trafficking and its modulation by the sex hormone E2 is a cellular mechanism critical for a major component of episodic memory, opening a new and noncanonical research avenue in the physiopathology of cognition.
authors: Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862 l'Institut National de la Santé et de la Recherche Médicale, Bordeaux, France; Université de Bordeaux (MP, FG, LB-B, LL, VL, SAA, LG), Bordeaux, France.
authors: Mylène
authors: M
authors: Potier
authors: Interdisciplinary Institute for NeuroSciences (FG, LL, LG, AM), Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5297, Bordeaux, France; Université de Bordeaux (MP, FG, LB-B, LL, VL, SAA, LG), Bordeaux, France.
authors: François
authors: F
authors: Georges
authors: Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862 l'Institut National de la Santé et de la Recherche Médicale, Bordeaux, France; Université de Bordeaux (MP, FG, LB-B, LL, VL, SAA, LG), Bordeaux, France.
authors: Laurent
authors: L
authors: Brayda-Bruno
authors: Interdisciplinary Institute for NeuroSciences (FG, LL, LG, AM), Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5297, Bordeaux, France; Université de Bordeaux (MP, FG, LB-B, LL, VL, SAA, LG), Bordeaux, France.
authors: Laurent
authors: L
authors: Ladépêche
authors: Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862 l'Institut National de la Santé et de la Recherche Médicale, Bordeaux, France; Université de Bordeaux (MP, FG, LB-B, LL, VL, SAA, LG), Bordeaux, France.
authors: Valérie
authors: V
authors: Lamothe
authors: Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862 l'Institut National de la Santé et de la Recherche Médicale, Bordeaux, France; Université de Bordeaux (MP, FG, LB-B, LL, VL, SAA, LG), Bordeaux, France.
authors: Alice Shaam
authors: AS
authors: Al Abed
authors: Interdisciplinary Institute for NeuroSciences (FG, LL, LG, AM), Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5297, Bordeaux, France; Université de Bordeaux (MP, FG, LB-B, LL, VL, SAA, LG), Bordeaux, France.
authors: Laurent
authors: L
authors: Groc
authors: Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862 l'Institut National de la Santé et de la Recherche Médicale, Bordeaux, France; Interdisciplinary Institute for NeuroSciences (FG, LL, LG, AM), Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5297, Bordeaux, France. Electronic address: aline.marighetto@inserm.fr.
authors: Aline
authors: A
authors: Marighetto
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D004958:Estradiol / Q000008:administration & dosage*; D017774:Long-Term Potentiation; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D021381:Protein Transport / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D013569:Synapses / Q000502:physiology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D004958:Estradiol
keywords: Episodic memory; Estrogen; Hippocampus; Lateral diffusion; Long-term potentiation; Temporal associations