title: Analysis of Relationships Between Prethrombotic States and Cervical Cancer.
abstract: OBJECTIVE
  To analyze the relationship between a prethrombotic state and the occurrence of thrombosis, as well as survival time for patients with cervical cancer.
  
  
  METHODS
  Patients with first diagnosis of cervical cancer were subgrouped according to FIGO staging, and two D-dimer levels were assessed. According to the results, patients are divided into an observation group (abnormal) and control group (normal).
  
  
  RESULTS
  For 106 patients with cervical cancer, 38 with abnormal D-dimer, the abnormal rate is 35.9%, of which stage I accounted for 6.5%, stageII 38.5%, stage III 50%, and stage IV 61.1% (p=0.013); The level of D-dimers in stageI wass 0.87±0.68ug/ ml, while in stage II it was 1.50±1.35ug/ml, stage III 2.60±1.86ug/ml and stage IV 18.6±53.4ug/ml (P=0.031); after follow-up of patients for 2-30 months, the mortality of observation group is 21.1%, while for control group it was 2.94% (p <0.01). In the observation group, survival time was 15.1±5.8 months, while for control group it was 21.0±5.4 months, the difference between two groups being highly significant (p=0.000).
  
  
  CONCLUSIONS
  There is a direct correlation between prethrombotic state and the grade malignancy of cervical cancer. The level is positively correlated with clinical stage, and is inversely related to survival time, so that a prethrombotic state could be used to predict the prognosis for patients with cervical cancer.
authors: Department of Gynaecology, Taizhou Second People's Hospital, the Affiliated Hospital of Yangzhou University, Taizhou, China E-mail : huangxinen06@163.com.
authors: You-Hong
authors: YH
authors: Sun
authors: Lin
authors: L
authors: Cui
authors: Jue
authors: J
authors: Chen
authors: Min
authors: M
authors: Wang
authors: Jian-Jun
authors: JJ
authors: Liu
authors: Xing-Xiang
authors: XX
authors: Liu
authors: Xin-En
authors: XE
authors: Huang
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000401:mortality / Q000473:pathology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000401:mortality / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D