title: [Involvement of adrenomedullin in the pathogenesis of inflammatory pain and morphine tolerance].
abstract: The increase of pronociceptive mediators in the dorsal root ganglia (DRG) and spinal dorsal horn is an important mechanism in the pathogenesis of inflammatory pain and opioid tolerance. Adrenomedullin (AM) belongs to calcitonin gene-related peptide (CGRP) family and has been recently demonstrated to be a pain-related peptide. It has also been shown that the expression and release of AM are increased in the DRG and spinal dorsal horn during inflammation and repeated use of morphine. Intrathecal administration of the selective AM receptor antagonist AM22-52 abolishes inflammatory pain and morphine tolerance, suggesting that enhanced AM receptor signaling in the DRG and spinal dorsal horn contributes to the induction of inflammatory pain and morphine tolerance. The present review highlights the recent developments regarding the involvement of AM in these two disorders. The neurological mechanisms of AM's actions are also discussed.
authors: Provincial Key Laboratory of Developmental Biology and Neuroscience, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China.
authors: Bing-Qing
authors: BQ
authors: Huang
authors: Provincial Key Laboratory of Developmental Biology and Neuroscience, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China. yhong@fjnu.edu.cn.
authors: Yanguo
authors: Y
authors: Hong
mesh_terms: D053607:Adrenomedullin / Q000494:pharmacology*; D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D004361:Drug Tolerance; D005727:Ganglia, Spinal / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D058265:Receptors, Adrenomedullin / Q000378:metabolism
chemical_list: D010446:Peptide Fragments; D058265:Receptors, Adrenomedullin; C104782:adrenomedullin (22-52); D053607:Adrenomedullin; D009020:Morphine; D015740:Calcitonin Gene-Related Peptide