title: Myostatin: expanding horizons.
abstract: Myostatin is a secreted growth and differentiation factor that belongs to the TGF-β superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels including epigenetic, transcriptional, post-transcriptional, and post-translational. New revelations regarding myostatin regulation also offer mechanisms that could be exploited for developing myostatin antagonists. Increasingly, it is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism. Hence, molecular mechanisms by which myostatin regulates several key metabolic processes need to be further explored.
authors: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.|Department of Cell & Molecular Biology, Brenner Centre for Molecular Medicine, Singapore Institute of Clinical Sciences (SICS), Singapore.
authors: Mridula
authors: M
authors: Sharma
authors: Department of Cell & Molecular Biology, Brenner Centre for Molecular Medicine, Singapore Institute of Clinical Sciences (SICS), Singapore.
authors: Craig
authors: C
authors: McFarlane
authors: Department of Cell & Molecular Biology, Brenner Centre for Molecular Medicine, Singapore Institute of Clinical Sciences (SICS), Singapore.|School of Biological Sciences, Nanyang Technological University, Singapore.
authors: Ravi
authors: R
authors: Kambadur
authors: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.
authors: Himani
authors: H
authors: Kukreti
authors: Department of Cell & Molecular Biology, Brenner Centre for Molecular Medicine, Singapore Institute of Clinical Sciences (SICS), Singapore.
authors: Sabeera
authors: S
authors: Bonala
authors: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.
authors: Shruti
authors: S
authors: Srinivasan
mesh_terms: D002454:Cell Differentiation / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D024510:Muscle Development / Q000235:genetics*; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism; D055435:Myostatin / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011499:Protein Processing, Post-Translational; D016212:Transforming Growth Factor beta / Q000235:genetics*
chemical_list: C525911:MSTN protein, human; D055435:Myostatin; D016212:Transforming Growth Factor beta
keywords: cancer cachexia; insulin resistance; muscle wasting; myostatin; sarcopenia; skeletal muscle