title: Tris(3-hydroxypropyl)phosphine (THPP): A mild, air-stable reagent for the rapid, reductive cleavage of small-molecule disulfides.
abstract: Tris(3-hydroxypropyl)phosphine (THPP) is demonstrated to be a versatile, water-soluble and air-stable reducing agent, allowing for the rapid, irreversible reductive cleavage of disulfide bonds in both aqueous and buffered aqueous-organic media. The reagent shows exceptional stability at biological pH under which condition it permits the rapid reduction of a wide range of differentially functionalized small-molecule disulfides.
authors: Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4M1, Canada.
authors: James
authors: J
authors: McNulty
authors: Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4M1, Canada.
authors: Venkatesan
authors: V
authors: Krishnamoorthy
authors: Cytec Canada Inc, 9061 Garner Rd., Niagara Falls, Ontario L2E 6S5, Canada.
authors: Dino
authors: D
authors: Amoroso
authors: Cytec Canada Inc, 9061 Garner Rd., Niagara Falls, Ontario L2E 6S5, Canada.
authors: Michael
authors: M
authors: Moser
mesh_terms: D000388:Air; D004220:Disulfides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000187:drug effects; D010720:Phosphines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004220:Disulfides; D007202:Indicators and Reagents; D010720:Phosphines; C000603174:tris(3-hydroxypropyl)phosphine
keywords: Aqueous chemistry; Cystine derivative; Disulfide cleavage; Thiols; Tris-(hydroxypropyl)phosphine