title: Association between TCF7L2 polymorphisms and breast cancer susceptibility: a meta-analysis.
abstract: OBJECTIVE
  Our aim was to investigate the relationship between transcription factor 7-like 2 (TCF7L2) polymorphisms and breast cancer susceptibility.
  
  
  METHODS
  PubMed, Embase and CNKI databases were used to search the related studies investigating the correlation between TCF7L2 polymorphisms and breast cancer susceptibility. Pooled ORs and 95% CIs, based on five genetic models, were applied to estimate the association betweenTCF7L2 polymorphisms and breast cancer. A fixed-effect model or a random-effect model was applied according to the between-study heterogeneity.
  
  
  RESULTS
  We analyzed six single nucleotide polymorphisms (SNPs) in TCF7L2 gene, namely rs12255372, rs7903146, rs7900150, rs3750805, rs1225404 and rs7003146. The increased risk of breast cancer was associated with TCF7L2 polymorphisms (22 vs. 11: OR=1.16, 95% CI=1.02-1.32; 22+12 vs. 11: OR=1.06, 95% CI=1.02-1.10; 22 vs. 11+12: OR=1.15, 95% CI=1.04-1.27; 2 vs. 1: OR=1.07, 95% CI=1.02-1.13; 12 vs. 11: OR=1.05, 95% CI=1.01-1.09). Among the locus, rs7903146 polymorphism was significantly associated with the risk for breast cancer under five genetic models (TT vs. CC: OR=1.29, 95% CI=1.08-1.53; TT+CT vs. CC: OR=1.09, 95% CI=1.01-1.18; TT vs. CC+CT: OR=1.24, 95% CI=1.05-1.48; T vs. C: OR=1.11, 95% CI=1.04-1.19; CT vs. CC: OR=1.08, 95% CI=1.00-1.17). Additionally, rs7900150 also showed effects on the susceptibility of breast cancer (TT vs. AA: OR=1.22, 95% CI=1.07-1.39; TT+AT vs. AA: OR=1.06, 95% CI=1.00-1.14; TT vs. AA+AT: OR=1.21, 95% CI=1.07-1.37; T vs. A: OR=1.09, 95% CI=1.02-1.15; AT vs. AA: OR=1.04, 95% CI=1.01-1.33). Meanwhile, we found that rs3750805 polymorphism could increased the risk for breast cancer (TT+AT vs. AA: OR=1.12, 95% CI=1.01-1.24).
  
  
  CONCLUSIONS
  Our meta-analysis demonstrates that TCF7L2 polymorphisms may increase the risk for breast cancer.
authors: Department of Breast Disease, The Second Hospital of Shandong University 247 Beiyuan Street, Tianqiao District, Jinan 250033, Shandong, China ; Department of Breast Disease, Beijing Tiantan Hospital, Capital Medical University Beijing 100050, China.
authors: Feng
authors: F
authors: Wang
authors: Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
authors: Lixin
authors: L
authors: Jiang
authors: Image Diagnostic Center, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
authors: Jianlin
authors: J
authors: Li
authors: Department of Endocrinology, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
authors: Xiao
authors: X
authors: Yu
authors: Department of Anesthesiology, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
authors: Mingchuan
authors: M
authors: Li
authors: Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
authors: Guochang
authors: G
authors: Wu
authors: Department of Anesthesiology, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
authors: Zhenyu
authors: Z
authors: Yu
authors: Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
authors: Kai
authors: K
authors: Zhou
authors: Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
authors: Haidi
authors: H
authors: Chu
authors: Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
authors: Huiyuan
authors: H
authors: Zhai
keywords: TCF7L2; breast cancer; polymorphisms