title: Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis.
abstract: The association between polymorphisms of glutathione-related enzyme (GST) genes and the risk of schizophrenia has been investigated in many published studies. However, their results were inconclusive. Therefore, we performed a meta-analysis to explore the association between the GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of schizophrenia. Twelve case-control studies were included in this meta-analysis. The odds ratio (OR) and 95% confidence interval (95% CI) were used to investigate the strength of the association. Our meta-analysis results revealed that GSTM1, GSTT1, and GSTP1 polymorphisms were not related to risk of schizophrenia (p > 0.05 in each model). Further analyses based on ethnicity, GSTM polymorphism showed weak association with schizophrenia in East Asian population (OR = 1.314, 95% CI = 1.025-1.684, p = 0.031). In conclusion, our meta-analysis indicated the GSTM1 polymorphism may be the only genetic risk factor for schizophrenia in East Asian population. However, more meta-analysis with a larger sample size were needed to provide more precise evidence.
authors: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea. skkim7@khu.ac.kr.
authors: Su Kang
authors: SK
authors: Kim
authors: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea. ifthisplus88@hanmail.net.
authors: Sang Wook
authors: SW
authors: Kang
authors: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea. jhchung@khu.ac.kr.
authors: Joo-Ho
authors: JH
authors: Chung
authors: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea. hjpark17@gmail.com.
authors: Hae Jeong
authors: HJ
authors: Park
authors: Department of Biomedical Laboratory Science, College of Health Sciences, Shinhan University, Gyeonggi 480-701, Korea. kbcho@shinhan.ac.kr.
authors: Kyu Bong
authors: KB
authors: Cho
authors: Department of Surgery, School of Medicine, Kyung Hee University, Seoul 130-702, Korea. ikireida@hanmail.net.
authors: Min-Su
authors: MS
authors: Park
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics; D005202:Asia, Eastern; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human
keywords: glutathione S-transferase enzymes; meta-analysis; polymorphism; schizophrenia