title: [CYSTEAMINE-INDUCED MODIFICATION OF CYTOGENETIC DAMAGES TO THE CORNEAL EPITHELIUM OF MICE EXPOSED TO CORPUSCULAR RADIATION WITH VARYING LINEAR TRANSFER ENERGIES].
abstract: Cytogenetic damages to cells of the corneal epithelium were studied in mice exposed to protons (10, 25, 50 and 645 MeV), ions of boron, carbon and neon, and X-rays (180 keV) within the dose range from 25 to 750 cGy and injected with a radioprotector. Animals were subjected to a single exposure. The protective effect of β-mercaptoethylamine was tested in the experiment. The radioprotector (0.2 ml) was introduced intraperitoneally 30 minutes before exposure in 350 mI/kg dose. Control animals received the same amount of sodium chloride solution. The animals were sacrificed by cervical dislocation in 24 and 72 hrs. after exposure. It was shown that cysteamine effectively protects in vivo corneal epithelium cells of mice exposed to electromagnetic radiation or protons in a broad energy spectrum (10 to 645 MeV), and to a broad range of radiation doses (25 to 750 cGy), as judged from levels of aberrant mitosis and mitotic activity. The radioprotector exhibited the highest effectiveness in animals exposed to the doses of 50 to 300 cGy. These findings prove that cysteamine may potentially be used for pharmacological protection from protons. The radioprotector failed to prevent chromosomal aberrations after exposure to heavy charged particles of boron, carbon and neon, which implies the need to design radioprotectors against this type of corpuscular radiation specifically.
authors: S V
authors: SV
authors: Vorozhtsova
authors: T M
authors: TM
authors: Bulynina
authors: A G
authors: AG
authors: Molokanov
authors: A A
authors: AA
authors: Ivanov
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects*; D003543:Cysteamine / Q000494:pharmacology*; D065104:Cystine Depleting Agents / Q000494:pharmacology; D020732:Cytogenetic Analysis; D004307:Dose-Response Relationship, Radiation; D019573:Epithelium, Corneal / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*; D005720:Gamma Rays / Q000009:adverse effects*; D018499:Linear Energy Transfer; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000473:pathology; D012062:Relative Biological Effectiveness
chemical_list: D065104:Cystine Depleting Agents; D003543:Cysteamine