title: Affective personality predictors of disrupted reward learning and pursuit in major depressive disorder.
abstract: Anhedonia, the diminished anticipation and pursuit of reward, is a core symptom of major depressive disorder (MDD). Trait behavioral activation (BA), as a proxy for anhedonia, and behavioral inhibition (BI) may moderate the relationship between MDD and reward-seeking. The present studies probed for reward learning deficits, potentially due to aberrant BA and/or BI, in active or remitted MDD individuals compared to healthy controls (HC). Active MDD (Study 1) and remitted MDD (Study 2) participants completed the modified monetary incentive delay task (mMIDT), a behavioral reward-seeking task whose response window parameters were individually titrated to theoretically elicit equivalent accuracy between groups. Participants completed the BI Scale and BA Reward-Responsiveness and Drive Scales. Despite individual titration, active MDD participants won significantly less money than HCs. Higher Reward-Responsiveness scores predicted more won; Drive and BI were not predictive. Remitted MDD participants' performance did not differ from controls', and trait BA and BI measures did not predict r-MDD performance. These results suggest that diminished reward-responsiveness may contribute to decreased motivation and reward pursuit during active MDD, but that reward learning is intact in remission. Understanding individual reward processing deficits in MDD may inform personalized intervention addressing anhedonia and motivation deficits in select MDD patients.
authors: Department of Psychiatry, University of Illinois - Chicago, Chicago, IL, USA.
authors: Sophie R
authors: SR
authors: DelDonno
authors: Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
authors: Anne L
authors: AL
authors: Weldon
authors: Department of Psychiatry, University of Illinois - Chicago, Chicago, IL, USA.
authors: Natania A
authors: NA
authors: Crane
authors: Department of Psychiatry, University of Illinois - Chicago, Chicago, IL, USA.
authors: Alessandra M
authors: AM
authors: Passarotti
authors: Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
authors: Patrick J
authors: PJ
authors: Pruitt
authors: Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
authors: Laura B
authors: LB
authors: Gabriel
authors: Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
authors: Wendy
authors: W
authors: Yau
authors: Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
authors: Kortni K
authors: KK
authors: Meyers
authors: Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
authors: David T
authors: DT
authors: Hsu
authors: Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
authors: Stephen F
authors: SF
authors: Taylor
authors: Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
authors: Mary M
authors: MM
authors: Heitzeg
authors: Department of Psychiatry, University of Illinois - Chicago, Chicago, IL, USA.
authors: Ellen
authors: E
authors: Herbener
authors: Department of Psychiatry, University of Illinois - Chicago, Chicago, IL, USA.
authors: Stewart A
authors: SA
authors: Shankman
authors: Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
authors: Brian J
authors: BJ
authors: Mickey
authors: Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA; Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
authors: Jon-Kar
authors: JK
authors: Zubieta
authors: Department of Psychiatry, University of Illinois - Chicago, Chicago, IL, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address: slangenecker@psych.uic.edu.
authors: Scott A
authors: SA
authors: Langenecker
mesh_terms: D000328:Adult; D059445:Anhedonia / Q000502:physiology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000523:psychology; D009042:Motivation; D010551:Personality / Q000502:physiology; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D012201:Reward; D055815:Young Adult
keywords: Behavioral activation; Behavioral inhibition; Depression; Remitted MDD; Reward processing