title: INFLAMMATORY, NUTRITIONAL AND CLINICAL PARAMETERS OF INDIVIDUALS WITH CHRONIC KIDNEY DISEASE UNDERGOING CONSERVATIVE TREATMENT.
abstract: BACKGROUND
  due to the relevance of inflammation in individuals with chronic kidney disease (CKD), inflammation should be taken into account in the interpretation of the clinical-nutritional status.
  
  
  OBJECTIVE
  assess the association between inflammation, nutritional and clinical parameters in patients with CKD.
  
  
  METHODS
  92 patients with CKD. C-reactive protein (CRP) was used as an inflammation marker. Assessed nutritional parameters were anthropometry and biochemical exams. Evaluated clinical parameters were comorbidities, CKD characteristics, lipid profile, lipid-lowering agents, urea, creatinine and total leukocytes. Comparisons between two groups (with or without inflammation) were performed using Student's t-test or chi-square test.
  
  
  RESULTS
  15 (16.3%) patients had CRP above ≥ 10mg/L and were considered with inflammation. In the group with inflammation, 05 (33%) had hypoalbuminemia as compared with 05 (6.5%) in the group without inflammation (p = 0.002). Lipid values were lower in the group with inflammation, with mean total cholesterol 171 (± 41.2) mg/dL and mean LDL-C 95 (± 31.2) mg/dL as compared with the group without inflammation, which had and a mean total cholesterol 198 (± 46) mg/dL and mean LDL-C 124 (± 40.1) mg/dL, p = 0,038 and p = 0.011, respectively. No other statistically significant differences between groups were found.
  
  
  CONCLUSIONS
  inflammation was associated with changes in the total cholesterol and LDL levels and with an increased incidence of hypoalbuminemia. We suggest that serum albumin levels should only be used to assess nutritional status in the absence of inflammation and CRP levels ought to be considered in nutritional status interpretation in patients with CKD.
authors: Master's degree in Food, Nutrition and Health, Federal University of Bahia.. fortes.alessandra@gmail.com.
authors: Alessandra
authors: A
authors: Fortes Almeida
authors: Master's degree in Food, Nutrition and Health, Federal University of Bahia; Assistant professor, School of Nutrition, Federal University of Bahia.. fortes.alessandra@gmail.com.
authors: Maria Helena
authors: MH
authors: Lima Gusmão-Sena
authors: Specialist in Clinical Nutrition, Residency program in Clinical Nutrition, School of Nutrition, Federal University of Bahia, Bahia.. fortes.alessandra@gmail.com.
authors: Layne Carla
authors: LC
authors: Gonzaga Oliveira
authors: Specialist in Clinical Nutrition, Residency program in Clinical Nutrition, School of Nutrition, Federal University of Bahia, Bahia.. fortes.alessandra@gmail.com.
authors: Tarcisio
authors: T
authors: Santana Gomes
authors: Specialist in Clinical Nutrition, Residency program in Clinical Nutrition, School of Nutrition, Federal University of Bahia, Bahia.. fortes.alessandra@gmail.com.
authors: Thais Vitorino
authors: TV
authors: Neves do Nascimento
authors: Medical Intensive Care Unit, Emergency Department, Hospital of Clinical, University of São Paulo Medical School, São Paulo.. fortes.alessandra@gmail.com.
authors: André Luiz
authors: AL
authors: Nunes Gobatto
authors: PhD (Nutrition), Federal University of São Paulo; Adjunct professor, School of Nutrition, Federal University of Bahia, Bahia.. fortes.alessandra@gmail.com.
authors: Lilian
authors: L
authors: Ramos Sampaio
authors: PhD in Nutrition, Federal University of Pernambuco; Adjunct professor, School of Nutrition, Federal University of Bahia, Brazil.. fortes.alessandra@gmail.com.
authors: Jairza María
authors: JM
authors: Barreto-Medeiros
mesh_terms: D000368:Aged; D015415:Biomarkers; D000072700:Conservative Treatment / Q000379:methods; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010045:Outpatients; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators