title: Targeting the WNT Signaling Pathway in Cancer Therapeutics.
abstract: The WNT signaling cascade is integral in numerous biological processes including embryonic development, cell cycle regulation, inflammation, and cancer. Hyperactivation of WNT signaling secondary to alterations to varying nodes of the pathway have been identified in multiple tumor types. These alterations converge into increased tumorigenicity, sustained proliferation, and enhanced metastatic potential. This review seeks to evaluate the evidence supporting the WNT pathway in cancer, the therapeutic strategies in modulating this pathway, and potential challenges in drug development.
authors: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Division of Medical Oncology and Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA.
authors: David
authors: D
authors: Tai
authors: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Division of Medical Oncology and Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA.
authors: Keith
authors: K
authors: Wells
authors: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Division of Medical Oncology and Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA.
authors: John
authors: J
authors: Arcaroli
authors: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Division of Medical Oncology and Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA.
authors: Chad
authors: C
authors: Vanderbilt
authors: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Division of Medical Oncology and Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA.
authors: Dara L
authors: DL
authors: Aisner
authors: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Division of Medical Oncology and Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA.
authors: Wells A
authors: WA
authors: Messersmith
authors: Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Division of Medical Oncology and Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA Christopher.Lieu@ucdenver.edu.
authors: Christopher H
authors: CH
authors: Lieu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000276:immunology / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000187:drug effects*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C495270:CTNNB1 protein, human; C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D051176:beta Catenin
keywords: Drug development; Frizzled; Signal transduction; WNT; β-Catenin