title: Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT.
abstract: OBJECTIVE
  The present randomized, double-blind, placebo-controlled study aimed to evaluate the effect of Zingiber officinale (ginger) consumption on some metabolic and clinical features of obesity.
  
  
  METHODS
  Eighty eligible obese women (aged 18-45 years) were randomly assigned to either ginger or placebo groups (receiving 2 g/day of ginger powder or corn starch as two 1 g tablets) for 12 weeks. Body mass index (BMI) and body composition were assessed every 4 weeks, and serum levels of leptin, adiponectin, resistin, insulin and glucose were determined before and after intervention. The homeostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) were also calculated.
  
  
  RESULTS
  Ginger consumption significantly decreased BMI, serum insulin and HOMA-IR index, along with increasing QUICKIs as compared to the placebo. Moreover, significant reductions in serum leptin, resistin and glucose were observed in both groups, especially in ginger group with nonsignificant differences between groups. The body composition and serum levels of adiponectin were not significantly changed in study groups.
  
  
  CONCLUSIONS
  In conclusion, our findings demonstrate a minor beneficial effect of 2 g ginger powder supplementation for 12 weeks on weight loss and some metabolic features of obesity. However, given the lack of data in this area, ongoing clinical trials are needed to further explore ginger's effectiveness.
authors: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Vahideh
authors: V
authors: Ebrahimzadeh Attari
authors: Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ostadrahimi@tbzmed.ac.ir.
authors: Alireza
authors: A
authors: Ostadrahimi
authors: Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mohammad
authors: M
authors: Asghari Jafarabadi
authors: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Sajjad
authors: S
authors: Mehralizadeh
authors: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Sepideh
authors: S
authors: Mahluji
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D020939:Zingiber officinale / Q000737:chemistry*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D052243:Resistin / Q000097:blood; D055815:Young Adult
chemical_list: D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D052243:Resistin
keywords: Adipocytokines; Obesity; Zingiber officinale Roscoe