title: Further evidence supporting the association of NKAPL with schizophrenia.
abstract: Schizophrenia (SZ) is a severe chronic mental disorder with complex genetic mechanisms. Increasing evidence implicate immune system dysfunction in the pathogenesis of SZ. The non-synonymous single nucleotide polymorphism (SNP) rs1635 in NKAPL, was identified by a genome-wide association study (GWAS) for SZ in Han Chinese from north China. A replication study failed to detect the association of rs1635 with SZ in Han Chinese from central south of China, while another one confirmed the positive association in Han Chinese from Taiwan. To further clarify these findings, we conducted a case-control association study of rs1635 in a cohort of Han Chinese from east China, including 1406 SZ cases and 1136 healthy controls. We detected a positive association of rs1635 with SZ, with the major allele (G) of rs1635 conferring a risk for SZ (P=0.033, OR=1.14). Our findings add further evidence for the involvement of NKAPL polymorphisms in the development of SZ.
authors: Mental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors: Zhiqiang
authors: Z
authors: Wang
authors: Mental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors: Bixiu
authors: B
authors: Yang
authors: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China.
authors: Yansong
authors: Y
authors: Liu
authors: Unit on Statistical Genomics, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States.
authors: Yin Yao
authors: YY
authors: Shugart
authors: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China.
authors: Zaohuo
authors: Z
authors: Cheng
authors: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China.
authors: Chunhui
authors: C
authors: Jin
authors: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China.
authors: Jianmin
authors: J
authors: Yuan
authors: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China.
authors: Wei
authors: W
authors: Zhu
authors: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China. Electronic address: wuwangguoqiang@126.com.
authors: Guoqiang
authors: G
authors: Wang
authors: Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu, China. Electronic address: zfqeee@126.com.
authors: Fuquan
authors: F
authors: Zhang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D056970:Co-Repressor Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D056970:Co-Repressor Proteins; C569368:NKAPL protein, human; D009687:Nuclear Proteins
keywords: NKAPL; Schizophrenia; rs1635