title: MUC1 (CD227): a multi-tasked molecule.
abstract: Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.
authors: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia. vasso.apostolopoulos@vu.edu.au.
authors: Vasso
authors: V
authors: Apostolopoulos
authors: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia.
authors: Lily
authors: L
authors: Stojanovska
authors: Prima BioMed Ltd, Sydney, NSW, Australia.
authors: Sharron E
authors: SE
authors: Gargosky
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D002450:Cell Communication; D004847:Epithelial Cells / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D018396:Mucin-1 / Q000737:chemistry* / Q000502:physiology*; D011247:Pregnancy; D020033:Protein Isoforms
chemical_list: C060192:MUC1 protein, human; D018396:Mucin-1; D020033:Protein Isoforms; C577056:muc1 protein, mouse
keywords: CD227; EMA; MUC1; MUC1 and cancer; MUC1 and disease; MUC1 and pathogens; MUC1 expression; MUC1 isoforms; MUC1 structure; PEM