title: Assessment of epicardial adipose tissue thickness in patients with resistant hypertension.
abstract: OBJECTIVE
  Recent studies have shown that epicardial adipose tissue (EAT) thickness is increased in patients with hypertension. In this study, we aimed to investigate the relation of EAT thickness with resistant hypertension (RHT).
  
  
  METHODS
  Study participants (n=150) were classified into three groups according to their office and ambulatory blood pressure measurements: RHT (n=50), controlled hypertension (CHT, n=50), and normotension (NT, n=50). All patients underwent a transthoracic echocardiographic examination to measure EAT thickness.
  
  
  RESULTS
  Clinical and biochemical characteristics of the groups were similar, except the CRP level, which was significantly increased in hypertensive patients compared with patients with NT (P<0.001). EAT thickness differed significantly between groups (P<0.001). The highest values were obtained in the RHT group (4.64±1.24 cm), followed by the CHT (3.3±0.82 cm) and NT (2.6±0.76 cm) groups. Multivariate analysis indicated age, physical activity level, and EAT thickness as independent predictors of RHT. The optimal cut-off value of EAT thickness for detection of RHT was found to be 3.42 cm, with a sensitivity and specificity of 82 and 77%, respectively (AUC=0.87, 95% confidence interval 0.81-0.92, P<0.000).
  
  
  CONCLUSIONS
  EAT can be effective on blood pressure by several mechanisms. In this study, for the first time in the literature, the association of EAT with RHT is reported.
authors: aDepartment of Cardiology, Ordu State Hospital, Ordu bDepartment of Cardiology, Okmeydani Training and Research Hospital cDepartment of Cardiology, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital dDepartment of Cardiology, School of Medicine, Acibadem University, Istanbul eDepartment of Cardiology, Kahramanmaraş Necip Fazil City Hospital, Kahramanmaraş fDepartment of Cardiology, Diyarbakir Gazi Yaşargil Training and Reseasrch Hospital, Diyarbakir, Turkey.
authors: Güney
authors: G
authors: Erdogan
authors: Erdal
authors: E
authors: Belen
authors: Mustafa A
authors: MA
authors: Sungur
authors: Aylin
authors: A
authors: Sungur
authors: Bariş
authors: B
authors: Yaylak
authors: Bariş
authors: B
authors: Güngör
authors: Şükrü
authors: Ş
authors: Akyüz
authors: Seçkin
authors: S
authors: Satilmiş
mesh_terms: D000273:Adipose Tissue / Q000473:pathology* / Q000503:physiopathology; D000368:Aged; D001794:Blood Pressure; D001795:Blood Pressure Determination; D018660:Blood Pressure Monitoring, Ambulatory; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000473:pathology* / Q000503:physiopathology