title: Modulation of Gut Microbiota-Brain Axis by Probiotics, Prebiotics, and Diet.
abstract: There exists a bidirectional communication system between the gastrointestinal tract and the brain. Increasing evidence shows that gut microbiota can play a critical role in this communication; thus, the concept of a gut microbiota and brain axis is emerging. Here, we review recent findings in the relationship between intestinal microbes and brain function, such as anxiety, depression, stress, autism, learning, and memory. We highlight the advances in modulating brain development and behavior by probiotics, prebiotics, and diet through the gut microbiota-brain axis. A variety of mechanisms including immune, neural, and metabolic pathways may be involved in modulation of the gut microbiota-brain axis. We also discuss some future challenges. A deeper understanding of the relationship between the gut bacteria and their hosts is implicated in developing microbial-based therapeutic strategies for brain disorders.
authors: College of Light Industry and Food Sciences, South China University of Technology , Guangzhou, China.
authors: Xiaofei
authors: X
authors: Liu
authors: Department of Psychology, Sun Yat-Sen University , Guangzhou, China.|Library, South China University of Technology , Guangzhou, China.
authors: Shangqing
authors: S
authors: Cao
authors: College of Light Industry and Food Sciences, South China University of Technology , Guangzhou, China.
authors: Xuewu
authors: X
authors: Zhang
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000178:diet therapy* / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D056692:Prebiotics / Q000008:administration & dosage*; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D056692:Prebiotics
keywords: brain function; diet; gut microbiota; prebiotics; probiotics