title: Intensive Periodontal Treatment Reduces Risk of Infection-Related Hospitalization in Hemodialysis Population: A Nationwide Population-Based Cohort Study.
abstract: Periodontal disease (PD) is prevalent and correlated with malnutrition and inflammation in patients on hemodialysis (HD). Periodontal therapy improves systemic inflammatory and nutritional markers in HD population. The relationship between intensive PD therapy and clinical infectious outcomes in patients on HD remains unclear.In total, 4451 patients who underwent HD and intensive PD treatment between January 1, 1998 and December 31, 2010 were selected from the National Health Insurance Research Database as the case cohort. The comparison cohort was selected by matching a patient without PD with each PD treated patient at a 1:1 ratio according to a propensity score. The rates of hospitalizations for infectious diseases for both cohorts were analyzed and compared.Compared with the comparison cohort, the hazard ratio (HR) of hospitalization for overall infectious diseases was 0.72 (95% confidence interval [CI] = 0.66-0.78, P < 0.001) for the intensive PD treatment cohort. The intensive PD treated cohort had a significantly lower risk of acute and subacute infective endocarditis (HR = 0.54, 95% CI = 0.35-0.84, P < 0.01), pneumonia (HR = 0.71, 95% CI = 0.65-0.78, P < 0.001), and osteomyelitis (HR = 0.77, 95% CI = 0.62-0.96, P < 0.05) than did the comparison cohort.The intensive PD treatment of patients with HD was associated with reduced risks of overall infectious diseases, acute and subacute infective endocarditis, pneumonia, and osteomyelitis. Our study concurs the role of a conventional intervention in enhancing infectious diseases outcomes.
authors: From the Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan (S-T,H T-M,Y M-J,W); Graduate Institute of Clinical Medicine Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan (S-T,H T-M,Y C-H,K); Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan (C-L,L); School of Medicine, China Medical University, Taichung, Taiwan (C-L,L); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-H,K).
authors: Shih-Ting
authors: ST
authors: Huang
authors: Cheng-Li
authors: CL
authors: Lin
authors: Tung-Min
authors: TM
authors: Yu
authors: Ming-Ju
authors: MJ
authors: Wu
authors: Chia-Hung
authors: CH
authors: Kao
mesh_terms: D000368:Aged; D001424:Bacterial Infections / Q000209:etiology* / Q000517:prevention & control*; D002681:China; D015331:Cohort Studies; D003422:Critical Care; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000150:complications* / Q000628:therapy*; D006435:Renal Dialysis; D012189:Retrospective Studies; D012307:Risk Factors