title: Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure.
abstract: Thyroid autoimmunity (TAI), which is defined as the presence of autoantibodies against thyroid peroxidase (TPO) and/or thyroglobulin (TG), is related to repeated implantation failure (RIF). It is reported that TAI was involved in reproductive failure not only through leading thyroid function abnormality, but it can also be accompanied with immune imbalance. Therefore, this study was designed to investigate the association of thyroid function, immune status and TAI in women with RIF. Blood samples were drawn from 72 women with RIF to evaluate the prevalence of TAI, the thyroid function, the absolute numbers and percentages of lymphocytes. The prevalence of thyroid function abnormality in RIF women with TAI was not significantly different from that in RIF women without TAI (c(2) = 0.484, p > 0.05). The absolute number and percentage of T cells, T helper (Th) cells, B cells and natural killer (NK) cells were not significantly different in RIF women with TAI compared to those without TAI (all p > 0.05). The percentage of T cytotoxicity (Tc) cells was significantly decreased in RIF women with TAI compared to those without TAI (p < 0.05). Meanwhile, Th/Tc ratio was significantly increased (p < 0.05). These results indicated that the decreased Tc percentage and increased Th/Tc ratio may be another influential factor of adverse pregnancy outcomes in RIF women with TAI.
authors: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China. huangchunyu200502@aliyun.com.|Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen 518045, China. huangchunyu200502@aliyun.com.|Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen 518045, China. huangchunyu200502@aliyun.com.
authors: Chunyu
authors: C
authors: Huang
authors: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China. victoria_lpy@hotmail.com.|Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen 518045, China. victoria_lpy@hotmail.com.|Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen 518045, China. victoria_lpy@hotmail.com.
authors: Peiyan
authors: P
authors: Liang
authors: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China. diaolianghui@gmail.com.|Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen 518045, China. diaolianghui@gmail.com.|Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen 518045, China. diaolianghui@gmail.com.
authors: Lianghui
authors: L
authors: Diao
authors: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China. lucyliucuicui@126.com.|Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen 518045, China. lucyliucuicui@126.com.|Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen 518045, China. lucyliucuicui@126.com.
authors: Cuicui
authors: C
authors: Liu
authors: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China. x_chen2011@163.com.|Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen 518045, China. x_chen2011@163.com.|Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen 518045, China. x_chen2011@163.com.
authors: Xian
authors: X
authors: Chen
authors: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China. liguangui@hotmail.com.|Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen 518045, China. liguangui@hotmail.com.|Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen 518045, China. liguangui@hotmail.com.
authors: Guangui
authors: G
authors: Li
authors: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China. congchen2015@sina.com.|Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen 518045, China. congchen2015@sina.com.|Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen 518045, China. congchen2015@sina.com.
authors: Cong
authors: C
authors: Chen
authors: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China. zengyong1966@gmail.com.|Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen 518045, China. zengyong1966@gmail.com.|Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen 518045, China. zengyong1966@gmail.com.
authors: Yong
authors: Y
authors: Zeng
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D010064:Embryo Implantation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D007453:Iodide Peroxidase / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology; D013960:Thyroid Function Tests; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D013954:Thyroglobulin; D007453:Iodide Peroxidase
keywords: infertility; lymphocytes; repeated implantation failure; thyroid autoimmunity