title: Cytochrome P450 2E1 RsaI/PstI polymorphism is associated with urologic cancer risk: evidence from a meta-analysis.
abstract: Cytochrome P450 2E1 (CYP2E1) is involved in the metabolic activation of various carcinogens. CYP2E1 RsaI/PstI polymorphism has been identified in urologic cancer patients, while studies of the polymorphism have shown inconclusive trends in the risk of urologic cancers. Therefore, we performed this systematic review to provide a complete picture and conducted a meta-analysis to derive a precise estimation. We searched PubMed, Embase and Web of Science to identify eligible studies up to December 15, 2014. 12 studies with 2712 cases and 2977 controls were included in the meta-analysis.The odds ratio with a 95% confidence interval was used to assess the strength of associations. We observed that the c2 allele of CYP2E1 RsaI/PstI polymorphism was associated with a decreased risk of urologic cancer under all genetic models (c2 vs. c1: OR = 0.742, 95% CI = 0.659-0.835); c2c2 vs. c1c1: OR = 0.516, 95% CI = 0.357-0.745; c1c2 vs. c1c1: OR = 0.748, 95% CI = 0.748 (0.648-0.863; c2c2 + c1c2 vs. c1c1: OR = 0.722, 95% CI = 0.629-0.829; c2c2 vs. c1c1 + c1c2: OR = 0.578, 95% CI = 0.401-0.832). In the subgroup analysis by cancer type, statistically significant associations were found in urothelial cancer in all genetic models. When stratified by ethnicity, a same trend was also indicated in Asians in all genetic models.To conclude, our results support the conclusion that the CYP2E1 RsaI/PstI polymorphism may be associated with urologic cancer susceptibility. The c2 allele is a low-penetrance risk factor for urologic cancer development.
authors: Department of Urology, Fujian Provincial Clinical College, Fujian Medical University Fuzhou, China ; Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, China.
authors: You-Cheng
authors: YC
authors: Lin
authors: Department of Urology, The First Affiliated Hospital of Jinan University Guangzhou, China ; Department of Anatomy, School of Basic Medicine Science, Southern Medical University Guangzhou, China.
authors: Xun
authors: X
authors: Wu
authors: Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University Guangzhou, China.
authors: Xue-Qiong
authors: XQ
authors: Zhou
authors: Department of Urology & Andrology, Zhongshan City People's Hospital Zhongshan, China.
authors: Rui
authors: R
authors: Ren
authors: Department of Urology, The First Affiliated Hospital of Jinan University Guangzhou, China ; Department of Anatomy, School of Basic Medicine Science, Southern Medical University Guangzhou, China.
authors: Ze-Xuan
authors: ZX
authors: Su
authors: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, China.
authors: Chun-Xiao
authors: CX
authors: Liu
keywords: Cytochrome P450 2E1; meta-analysis; polymorphism; susceptibility; urologic cancer