title: Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus.
abstract: Enterococcus faecalis and Streptococcus gallolyticus cause infective endocarditis (IE), which can originate from the continuous release or translocation of low bacterial numbers into the bloodstream. In this context, IE cannot be prevented with antibiotics. We previously demonstrated that aspirin plus ticlopidine protected rats from IE due to S. gordonii and Staphylococcus aureus. Here we showed that aspirin plus ticlopidine significantly reduced vegetation weight and protected 73 and 64% rats (P < 0.005) from IE due to E. faecalis and S. gallolyticus, respectively. These results further support the potential use of aspirin plus ticlopidine for a global prevention of IE in high-risk patients.
authors: Department of Fundamental Microbiology, University of Lausanne, CH-1015 Lausanne, Switzerland.
authors: Tiago Rafael
authors: TR
authors: Veloso
authors: Department of Fundamental Microbiology, University of Lausanne, CH-1015 Lausanne, Switzerland.
authors: Frank
authors: F
authors: Oechslin
authors: Department of Intensive Care Medicine, Lausanne University Hospital Center (CHUV), CH-1011 Lausanne, Switzerland.
authors: Yok-Ai
authors: YA
authors: Que
authors: Department of Fundamental Microbiology, University of Lausanne, CH-1015 Lausanne, Switzerland.
authors: Philippe
authors: P
authors: Moreillon
authors: Department of Fundamental Microbiology, University of Lausanne, CH-1015 Lausanne, Switzerland jose.entenza@unil.ch.
authors: José Manuel
authors: JM
authors: Entenza
authors: Department of Fundamental Microbiology, University of Lausanne, CH-1015 Lausanne, Switzerland.
authors: Stefano
authors: S
authors: Mancini
mesh_terms: D000818:Animals; D001241:Aspirin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004697:Endocarditis, Bacterial / Q000382:microbiology / Q000517:prevention & control*; D013293:Enterococcus faecalis / Q000254:growth & development*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D017208:Rats, Wistar; D013291:Streptococcus / Q000254:growth & development*; D013988:Ticlopidine / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine; D001241:Aspirin
keywords: Enterococcus faecalis; Streptococcus gallolyticus; antiplatelets; experimental endocarditis; prophylaxis