title: [Effect of Ikaros in B Cell Acute Lymphoblastic Leukemia].
abstract: The Ikaros - a DNA-binding zinc finger protein, acting as a regulator of chromatin remodeling and gene transcription, is crucial for regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Function-loss mutations of IKZF1, gene encoding Ikaros are frequent in B cell acute lymphoblastic leukemia (B-ALL) and are associated with a poor prognosis. This review briefly summarizes the available data regarding the structure and function of Ikaros, the role of Ikaros as a tumor suppressor in B-ALL, and its regulation mechanism.
authors: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Commond General Hospital, Lanzhou 730050, Gansu Province, China.
authors: Hai-Ying
authors: HY
authors: Zhang
authors: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Commond General Hospital, Lanzhou 730050, Gansu Province, China . E-mail: baihai98@tom.com.
authors: Hai
authors: H
authors: Bai
mesh_terms: D001402:B-Lymphocytes; D002454:Cell Differentiation; D016147:Genes, Tumor Suppressor; D006801:Humans; D051740:Ikaros Transcription Factor; D009154:Mutation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma
chemical_list: D051740:Ikaros Transcription Factor