title: CD146 as an adverse prognostic factor in uterine sarcoma.
abstract: BACKGROUND
  Uterine sarcoma is an aggressive malignancy with a poor prognosis. This study aimed to determine the expression of CD146, P53, and Ki-67 in uterine sarcoma and to evaluate their prognostic significance.
  
  
  METHODS
  We retrospectively analyzed the prognosis and clinicopathologic features of 68 patients with uterine sarcoma. Immunohistochemical analyses of CD146, P53, and Ki-67 were performed in tissue samples collected from these patients and their relationship with prognosis was investigated.
  
  
  RESULTS
  The 5-year overall survival (OS) rate was 46 %. Endometrial stromal sarcoma (ESS) patients had a better prognosis than leiomyosarcoma (LMS) patients, with a 2-year survival rate of 82 %. The membrane and cytoplasm of tumor cells exhibited CD146 overexpression in 8 (32 %) ESS cases, which was less than the 25 (69.4 %) cases observed in LMS and 2 (28.6 %) in MMMT. CD146 overexpression in the membrane and cytoplasm of tumor cells was closely related to lymph node metastasis (P = 0.021) and Ki-67 overexpression (P = 0.0053); there was no significant correlation with age, tumor size, International Federation of Obstetrics and Gynecology stage, or P53 overexpression in LMS.
  
  
  CONCLUSIONS
  CD146, P53, and Ki-67 are overexpressed in uterine sarcoma. CD146 expression correlates with lymph node metastasis and is associated with poor OS in LMS; it may be a potential prognostic marker for LMS.
authors: Department of Gynecology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. zhouyun@sysucc.org.cn.|State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. zhouyun@sysucc.org.cn.|Collaborative Innovation Center for Cancer, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, People's Republic of China. zhouyun@sysucc.org.cn.
authors: Yun
authors: Y
authors: Zhou
authors: Department of Gynecology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. huangh@sysucc.org.cn.|State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. huangh@sysucc.org.cn.|Collaborative Innovation Center for Cancer, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, People's Republic of China. huangh@sysucc.org.cn.
authors: He
authors: H
authors: Huang
authors: Department of Gynecology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. yuanlj@sysucc.org.cn.|State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. yuanlj@sysucc.org.cn.|Collaborative Innovation Center for Cancer, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, People's Republic of China. yuanlj@sysucc.org.cn.
authors: Lin-Jing
authors: LJ
authors: Yuan
authors: Department of Gynecology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. xiongy@sysucc.org.cn.|State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. xiongy@sysucc.org.cn.|Collaborative Innovation Center for Cancer, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, People's Republic of China. xiongy@sysucc.org.cn.
authors: Ying
authors: Y
authors: Xiong
authors: Department of Gynecology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. huangx@sysucc.org.cn.|State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. huangx@sysucc.org.cn.|Collaborative Innovation Center for Cancer, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, People's Republic of China. huangx@sysucc.org.cn.
authors: Xin
authors: X
authors: Huang
authors: Department of Gynecology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. linjx@sysucc.org.cn.|State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. linjx@sysucc.org.cn.|Collaborative Innovation Center for Cancer, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, People's Republic of China. linjx@sysucc.org.cn.
authors: Jia-Xin
authors: JX
authors: Lin
authors: Department of Gynecology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. zhengmin@sysucc.org.cn.|State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China. zhengmin@sysucc.org.cn.|Collaborative Innovation Center for Cancer, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, People's Republic of China. zhengmin@sysucc.org.cn.
authors: Min
authors: M
authors: Zheng
mesh_terms: D051929:CD146 Antigen / Q000276:immunology; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000276:immunology; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000276:immunology / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000276:immunology; D014594:Uterine Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D051929:CD146 Antigen; D019394:Ki-67 Antigen; C497902:MCAM protein, human; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53