title: Changes in secondary hyperparathyroidism-related biochemical parameters and medication use following parathyroidectomy.
abstract: BACKGROUND
  Little is known about changes in parathyroid hormone (PTH), calcium and phosphorous levels after parathyroidectomy in hemodialysis patients. We studied the effects of parathyroidectomy on these biochemical values in a large cohort of patients receiving maintenance hemodialysis.
  
  
  METHODS
  This retrospective cohort study included patients identified in both the United States Renal Data System and the database of a large dialysis organization who underwent parathyroidectomy in 2007-09, were aged ≥ 18 years, had Medicare Parts A and B as primary payer and had received hemodialysis for ≥ 1 year pre-parathyroidectomy. Descriptive statistics were calculated for continuous variables; categorical variables were used to characterize the population and evaluate monthly laboratory and medication use; median values were calculated for laboratory measures.
  
  
  RESULTS
  Among 1402 parathyroidectomy patients, mean age was 48.9 years, 52.4% were males, 58.8% were African American and mean dialysis duration was 7.5 years. Median PTH levels increased over the year before parathyroidectomy from 1039 to 1661 pg/mL and decreased afterward to 98 pg/mL at 1 month; levels remained ≥ 897 pg/mL for 10% of patients. Median calcium levels fell from 9.6 mg/dL before to 7.9 mg/dL 1 month after parathyroidectomy; levels were ≤ 7.1 mg/dL for 25% and remained ≤ 7.2 mg/dL for the lowest 25% at 3 months. Median phosphorous level was 6.8 mg/dL immediately before parathyroidectomy, decreased to 3.8 mg/dL immediately after and reached 5.8 mg/dL at 1 year.
  
  
  CONCLUSIONS
  While PTH levels dropped after parathyroidectomy for most patients, surgery was sometimes ineffective in reducing levels and sometimes led to over-suppression. Hypocalcemia could be profound and long lasting, suggesting the need for prolonged vigilance.
authors: Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN, USA.
authors: James B
authors: JB
authors: Wetmore
authors: Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN, USA.
authors: Jiannong
authors: J
authors: Liu
authors: Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA.
authors: Thy P
authors: TP
authors: Do
authors: Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA.
authors: Kimberly A
authors: KA
authors: Lowe
authors: Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN, USA Section of Renal Diseases and Hypertension, Minneapolis Veterans Administration Health Care System, Minneapolis, MN, USA Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
authors: Areef
authors: A
authors: Ishani
authors: Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA.
authors: Brian D
authors: BD
authors: Bradbury
authors: Denver Nephrology Clinical Research Division, Denver, CO, USA.
authors: Geoffrey A
authors: GA
authors: Block
authors: Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN, USA Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
authors: Allan J
authors: AJ
authors: Collins
mesh_terms: D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood* / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium
keywords: dialysis; end-stage renal disease; mineral metabolism; parathyroidectomy; secondary hyperparathyroidism