title: Midterm Outcome of Living-Related Kidney Transplantation From Aged Donors: A Single-Center Experience.
abstract: BACKGROUND
  Kidney transplantation (KT) is the most effective treatment of end-stage renal disease (ESRD). Using grafts from aged donors is increasing worldwide. Our aim was to better understand the safety and effectiveness of aged living donors.
  
  
  METHODS
  First, 482 cases with living-related kidney transplantation were analyzed retrospectively. The cases were divided into 2 groups by donor age ≥ 55 years (aged donor group, 136 cases) and <55 years (young donor group, 346 cases). Then donor and recipient characteristics were summarized. In addition, the renal function of graft was compared between young donor group and aged donor group. Finally, patient and graft survivals were examined with the use of Kaplan-Meier analysis and compared with the use of the log-rank test.
  
  
  RESULTS
  The mean donor estimated glomerular filtration rate (eGFR) was lower in the aged donor group compared with in the young donor group. After KT, the mean eGFR of the graft in the recipient was also lower in the aged donor group than in the young donor group. To confirm the effect of aged kidney grafts on renal function, we measured proteinuria. Compared with the young donor group, in the aged donor group incidence of proteinuria and 24-hour urinary protein were significantly higher. However, the incidence of delayed graft function was not significantly different between the 2 groups. We found that aged kidney grafts had no significant effect on long-term patient and graft survivals.
  
  
  CONCLUSIONS
  With the current lack of organs, aged kidney grafts are an acceptable alternative. Use of organs from aged donors safely expands the living donor pool.
authors: Transplantation Center, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.
authors: K
authors: K
authors: Cheng
authors: Transplantation Center, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.
authors: Z
authors: Z
authors: Huang
authors: Transplantation Center, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.
authors: Q
authors: Q
authors: Ye
authors: Transplantation Center, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.
authors: Y
authors: Y
authors: Ming
authors: Transplantation Center, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.
authors: Y
authors: Y
authors: Zhao
authors: Transplantation Center, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.
authors: L
authors: L
authors: Liu
authors: Transplantation Center, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China.
authors: S
authors: S
authors: Zhang
authors: Transplantation Center, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China. Electronic address: czzxiangya@aliyun.com.
authors: Z
authors: Z
authors: Chen
authors: Transplantation Center, Third Xiangya Hospital of Central South University, Changsha, People's Republic of China. Electronic address: wqxiangya@163.com.
authors: Q
authors: Q
authors: Wang
mesh_terms: D000328:Adult; D000367:Age Factors; D002681:China / Q000453:epidemiology; D051799:Delayed Graft Function / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult