title: Domino Heck/borylation sequence towards indolinone-3-methyl boronic esters: trapping of the σ-alkylpalladium intermediate with boron.
abstract: Pd-catalyzed domino Heck/borylation of acrylamides with B2pin2 is reported to generate synthetically useful indolinone-3-methyl boronic esters, via capturing σ-alkyl palladium with boron. Further functionalization of the obtained boronic ester qualify it as a new starting point for the functionalization of specific C(sp(3))-H bond. Moreover, the application of an Ugi-adduct as starting material or B2nep2 as an alternative boron source works equally well, making this a broadly applicable and robust method for the formation of a C-C and C-B bond in a single operation.
authors: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium. erik.vandereycken@chem.kuleuven.be.
authors: Dipak D
authors: DD
authors: Vachhani
authors: Himanshu H
authors: HH
authors: Butani
authors: Nandini
authors: N
authors: Sharma
authors: Umed C
authors: UC
authors: Bhoya
authors: Anamik K
authors: AK
authors: Shah
authors: Erik V
authors: EV
authors: Van der Eycken