title: Prenylated Dihydrochalcones from Artocarpus altilis as Antiausterity Agents.
abstract: Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. A novel antiausterity strategy in anticancer drug discovery led to the discovery of agents that preferentially inhibit the survival of cancer cells under low nutrient conditions. Artocarpus altilis (Family: Moraceae) is commonly referred to as breadfruit, traditionally for the treatment of many diseases. Many prenylated flavonoid and prenylated chalocones together with their cancer cell cytotoxicity were reported from this plant. This chapter briefly summarizes the constituents, biosynthesis, cytotoxicity, and antiausterity activity on PANC-1 human pancreatic cancer cell line of A. altilis.
authors: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, Viet Nam. Electronic address: nttmai@hcmus.edu.vn.
authors: Mai Thanh Thi
authors: MT
authors: Nguyen
authors: Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, Viet Nam.
authors: Nhan Trung
authors: NT
authors: Nguyen
authors: Frontier Research Core for Life Sciences, University of Toyama, Toyama, Japan.
authors: Suresh
authors: S
authors: Awale
keywords: Antiausterity activity; Artocarpus altilis; Pancreatic cancer; Prenylated dihydrochalcone