title: An Association Study on IL16 Gene Polymorphisms with the Risk of Sporadic Alzheimer's Disease.
abstract: BACKGROUND
  Interleukin-16 (IL-16) is an important regulator of T cell activation and was reported to act as a chemoattractant agent. There are evidences that IL16 can control the neuroinflammatory processes in Alzheimer's Disease (AD). This study was performed to investigate the role or association of IL16 polymorphisms, rs11556218 and rs4778889 with the risk of late-onset Alzheimer's disease (LOAD) in Iranian population.
  
  
  METHODS
  Totally, 148 AD patients and 137 nondemented and age-matched subjects were recruited in this study. Genotyping of rs11556218 T/G and rs4778889 T/C polymorphisms was performed by PCR-RFLP method using the NdeI and AhdI restriction enzymes, respectively.
  
  
  RESULTS
  Statistical analysis of rs11556218 genotypes showed a protective effect against AD in the heterozygote genotype (p=0.001, OR=0.16) as well as rs4778889 (p=0.001, OR=0.23). Frequency of rs11556218 allele T was higher in controls than patients (p=0.001, OR=0.32). However, there was no significant difference in the frequencies of rs4778889 alleles between the AD patients and controls.
  
  
  CONCLUSIONS
  Our results indicate that the rs11556218 and rs4778889 polymorphisms have a protective role in the development of sporadic AD in Iranian population.
authors: Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors: Tayyebeh
authors: T
authors: Khoshbakht
authors: Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors: Mohsen
authors: M
authors: Soosanabadi
authors: Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors: Maryam
authors: M
authors: Neishaboury
authors: Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
authors: Koorosh
authors: K
authors: Kamali
authors: Department of Biostatistics and Computer, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors: Masoud
authors: M
authors: Karimlou
authors: Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors: Nilofar
authors: N
authors: Bazazzadegan
authors: Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors: Hamid Reza
authors: HR
authors: Khorram Khorshid
keywords: Alzheimer's disease; Genetic association study; Interleukin-16; Polymorphism