title: Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users.
abstract: Adiponectin is an important marker of anthropometric profiles of adipose tissue. However, association of adiponectin and adiposity in HIV mono- and co-infected and hepatitis (HCV) injection drug users (IDUs) has not been elucidated. Therefore, the relationship of total adiponectin levels with anthropometric indices of adiposity was examined in HIV mono-infected (anti-retroviral treatment, ART-naive, n=16 and -experienced, n=34); HCV mono-infected, n=36; HIV and HCV co-infected (ART-naive, n=5 and -experienced, n=13); uninfected, n=19 IDUs; and healthy controls, n=16 from coastal Kenya. Anthropometric indices of adiposity were recorded and total circulating adiponectin levels were measured in serum samples using enzyme-linked immunosorbent assay. Adiponectin levels differed significantly amongst the study groups (P<0.0001). Post-hoc analyses revealed decreased levels in HIV mono-infected ART-naive IDUs in comparison to uninfected IDUs (P<0.05) and healthy controls (P<0.05). However, adiponectin levels were elevated in HCV mono-infected IDUs relative to HIV mono-infected ART-naive (P<0.001) and -experienced (P<0.001) as well as HIV and HCV co-infected ART-naive (P<0.05) IDUs. Furthermore, adiponectin correlated with weight (ρ=0.687; P=0.003) and BMI (ρ=0.598; P=0.014) in HIV mono-infected ART-naive IDUs; waist circumference (ρ=-0.626; P<0.0001), hip (ρ=-0.561; P=0.001) circumference, and bust-to-waist ratio (ρ=0.561; P=0.001) in HIV mono-infected ART-experienced IDUs; waist girth (ρ=0.375; P=0.024) in HCV mono-infected IDUs; and waist-to-hip ratio (ρ=-0.872; P=0.048) in HIV and HCV co-infected ART-naive IDUs. Altogether, these results suggest suppression of adiponectin production in treatment-naive HIV mono-infected IDUs and that circulating adiponectin is a useful surrogate marker of altered adiposity in treatment-naive and -experienced HIV and HCV mono- and co-infected IDUs.
authors: Bomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
authors: Eric M
authors: EM
authors: Ndombi
authors: Bomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
authors: Valentine
authors: V
authors: Budambula
authors: Bomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
authors: Mark K
authors: MK
authors: Webale
authors: Bomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
authors: Francis O
authors: FO
authors: Musumba
authors: Bomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
authors: Jesca O
authors: JO
authors: Wesongah
authors: Bomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
authors: Erick
authors: E
authors: Mibei
authors: Bomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
authors: Aabid A
authors: AA
authors: Ahmed
authors: Bomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
authors: Raphael
authors: R
authors: Lihana
authors: Bomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya mugogwe@yahoo.com.
authors: Tom
authors: T
authors: Were
keywords: HIV; adiponectin; anthropometric markers of adiposity; anti-retroviral treatment; hepatitis C virus; injection drug users