title: Rapid analysis of biogenic amines from rice wine with isotope-coded derivatization followed by high performance liquid chromatography-tandem mass spectrometry.
abstract: A pair of isotope-coded derivatization reagents, d0-10-methyl-acridone-2-sulfonyl chloride (d0-MASC, light form) and d3-10-methyl-acridone-2-sulfonyl chloride (d3-MASC, heavy form), were used for labeling biogenic amines (BAs). On basis of the isotope-coded derivatization, a global isotope internal standard quantitative method for determining seven BAs by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed. The d0-MASC and d3-MASC can easily label BAs under mild conditions within 15 min at 50 °C. The obtained light and heavy labeled BAs were monitored by the transitions of [M+H](+) → 208 and [M+H](+) → 211, respectively. Relative quantification of BAs was achieved by calculation of the peak area ratios of d0-MASC/d3-MASC labeled derivatives. Excellent linear responses for relative quantification were observed in the range of 1/10-10/1. The developed method has been successfully applied to the quantification of BAs in Chinese rice wine with recoveries ranging from 94.9% to 104.5%.
authors: Key Laboratory of Life-Organic Analysis of Shandong Province, Qufu Normal University, Qufu, PR China.
authors: Yiping
authors: Y
authors: Cai
authors: Key Laboratory of Life-Organic Analysis of Shandong Province, Qufu Normal University, Qufu, PR China. Electronic address: sunzhiw@126.com.
authors: Zhiwei
authors: Z
authors: Sun
authors: Key Laboratory of Pharmaceutical Intermediates and Natural Products, Qufu, PR China.
authors: Guang
authors: G
authors: Chen
authors: Key Laboratory of Pharmaceutical Intermediates and Natural Products, Qufu, PR China.
authors: Xiaomei
authors: X
authors: Liu
authors: Key Laboratory of Pharmaceutical Intermediates and Natural Products, Qufu, PR China; Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, PR China. Electronic address: jmyou6304@163.com.
authors: Jinmao
authors: J
authors: You
authors: Qianfoshan Hospital, Shandong University, Jinan, PR China.
authors: Caiqing
authors: C
authors: Zhang
mesh_terms: D001679:Biogenic Amines / Q000032:analysis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D012275:Oryza; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014920:Wine / Q000032:analysis*
chemical_list: D001679:Biogenic Amines
keywords: Biogenic amines (BAs); Chinese rice wine; High-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS); Isotope-coded derivatization reagent