title: Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor.
abstract: In this issue of Molecular Cell, Nilson et al. (2015) took advantage of THZ1, a recently described covalent inhibitor of the TFIIH kinase CDK7, to further characterize the role of this enzyme in the early stages of transcription and postprocessing events. They unveiled an unexpected function of CDK7 in RNA polymerase II pausing and mRNA capping.
authors: IGBMC, Department of Functional Genomics and Cancer, Equipe Labellisée Ligue 2014, CNRS/INSERM/University of Strasbourg, BP 163, 67404 Illkirch Cedex, C.U. Strasbourg, France. Electronic address: fredr@igbmc.fr.
authors: Frédéric
authors: F
authors: Coin
authors: IGBMC, Department of Functional Genomics and Cancer, Equipe Labellisée Ligue 2014, CNRS/INSERM/University of Strasbourg, BP 163, 67404 Illkirch Cedex, C.U. Strasbourg, France. Electronic address: egly@igbmc.fr.
authors: Jean-Marc
authors: JM
authors: Egly
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D018844:Cyclin-Dependent Kinases / Q000737:chemistry*; D006801:Humans; D010655:Phenylenediamines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D061785:Transcription Initiation, Genetic
chemical_list: D000970:Antineoplastic Agents; D010655:Phenylenediamines; D011743:Pyrimidines; D018844:Cyclin-Dependent Kinases