title: A Single-Center Retrospective Comparison of Doxorubicin-Loaded HepaSphere Transarterial Chemoembolization with Conventional Transarterial Chemoembolization for Patients with Unresectable Hepatocellular Carcinoma.
abstract: OBJECTIVE
  To compare doxorubicin-loaded HepaSphere transarterial chemoembolization versus conventional transarterial chemoembolization in terms of survival, time to recurrence, acute reversible hepatotoxicity, postembolization syndrome, and chemoembolization-related mortality and morbidity.
  
  
  METHODS
  One hundred twenty-six patients (103 men, 23 women; mean age, 64.3 y) with unresectable hepatocellular carcinoma (HCC) who underwent conventional chemoembolization between January 2007 and March 2011 or drug-eluting embolic (DEE) chemoembolization (after the protocol change) between March 2011 and October 2014 were included in a retrospective analysis. Primary outcome measures were survival and time to recurrence. Secondary outcome measures were frequency of recurrence, technical success, acute reversible hepatotoxicity, postembolization syndrome, and chemoembolization-related mortality and morbidity.
  
  
  RESULTS
  The technical success rate was 97.1%. There were no significant differences between the conventional and DEE chemoembolization groups with regard to mean survival duration (39.0 vs 37.4 mo), recurrence (32.9% vs 39.6%), postembolization syndrome (90% vs 89%), and chemoembolization-related mortality (5.5% vs 1.9%) and morbidity (9.6% vs 9.4%; P > .05). The time to recurrence was shorter in DEE chemoembolization-treated patients than in conventional chemoembolization-treated patients (5.0 vs 11.5 mo; P = .006), and acute reversible hepatotoxicity occurred more frequently after conventional chemoembolization (P = .019).
  
  
  CONCLUSIONS
  Conventional chemoembolization and DEE chemoembolization were safe and effective interventions for unresectable HCC. DEE chemoembolization was not better than conventional chemoembolization in terms of survival and was associated with a shorter time to recurrence. Acute reversible hepatotoxicity occurred more frequently after conventional chemoembolization.
authors: Department of Interventional Radiology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey. Electronic address: fkucukay@hotmail.com.
authors: Fahrettin
authors: F
authors: Kucukay
authors: Department of Interventional Radiology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey.
authors: Serife
authors: S
authors: Badem
authors: Department of Interventional Radiology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey.
authors: Adnan
authors: A
authors: Karan
authors: Department of Interventional Radiology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey.
authors: Mustafa
authors: M
authors: Ozdemir
authors: Department of Interventional Radiology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey.
authors: Riza S
authors: RS
authors: Okten
authors: Department of Interventional Radiology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey.
authors: Nilgun I
authors: NI
authors: Ozbulbul
authors: Department of Internal Medicine, Lokman Hekim Hospital, Ankara, Turkey.
authors: Murat B
authors: MB
authors: Kucukay
authors: Department of Gastrointestinal Surgery, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey.
authors: Ipek
authors: I
authors: Unlu
authors: Department of Gastrointestinal Surgery, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey.
authors: Erdal B
authors: EB
authors: Bostanci
authors: Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey.
authors: Meral
authors: M
authors: Akdogan
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods / Q000401:mortality*; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011859:Radiography; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin