title: Tailoring liquid crystalline lipid nanomaterials for controlled release of macromolecules.
abstract: Lipid-based liquid crystalline materials are being developed as drug delivery systems. However, the use of these materials for delivery of large macromolecules is currently hindered by the small size of the water channels in these structures limiting control over diffusion behaviour. The addition of the hydration-modulating agent, sucrose stearate, to phytantriol cubic phase under excess water conditions incrementally increased the size of these water channels. Inclusion of oleic acid enabled further control of swelling and de-swelling of the matrix via a pH triggerable system where at low pH the hexagonal phase is present and at higher pH the cubic phase is present. Fine control over the release of various sized model macromolecules is demonstrated, indicating future application to controlled loading and release of large macromolecules such as antibodies.
authors: Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, Australia.
authors: Nicole B
authors: NB
authors: Bisset
authors: Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, 381 Royal Parade, Parkville, VIC, Australia. Electronic address: ben.boyd@monash.edu.
authors: Ben J
authors: BJ
authors: Boyd
authors: Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, Australia. Electronic address: charlie.dong@monash.edu.
authors: Yao-Da
authors: YD
authors: Dong
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005233:Fatty Alcohols / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D050866:Liquid Crystals / Q000737:chemistry*; D046911:Macromolecular Substances / Q000008:administration & dosage*; D049329:Nanostructures / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry; D013395:Sucrose / Q000031:analogs & derivatives / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D005233:Fatty Alcohols; D046911:Macromolecular Substances; D014867:Water; C018153:sucrose monostearate; D019301:Oleic Acid; D013395:Sucrose; C508873:3,7,11,15-tetramethyl-1,2,3-hexadecanetriol
keywords: Cubic phase; Hexagonal phase; Lipids; Stimuli responsive liquid-crystal; Sustained-release