title: Effect of fluoxetine on induced tooth movement in rats.
abstract: BACKGROUND
  Fluoxetine is a widely used antidepressant. Its various effects on bone mineral density are well described. The aim of this study was to evaluate the effect of fluoxetine on induced tooth movement.
  
  
  METHODS
  Seventy-two Wistar rats were divided into 3 groups: M (n = 24; 0.9% saline solution and induced tooth movement), FM (n = 24; fluoxetine, 10 mg/kg, and induced tooth movement), and F (n = 24; fluoxetine, 10 mg/kg only). After 30 days of daily saline solution or fluoxetine administration, an orthodontic appliance (30 cN) was used to displace the first molar mesially in groups M and FM. The animals were killed 3, 7, and 14 days after placement of the orthodontic appliances. The animals in group F did not receive induced tooth movement but were killed at the same times. We evaluated tooth movement rates, collagen neoformation rates by polarization microscopy, numbers of osteoclast by tartrate-resistant acid phosphatase, and trabecular bone modeling by microcomputed tomography of the femur.
  
  
  RESULTS
  The tooth movement rates were similar in groups M and FM at all studied time points (P >0.05). The rate of newly formed collagen had a reverse pattern in groups M and FM, but the difference was not statistically significant (P >0.05). There were significantly more osteoclasts in group FM than in group F on day 3 (P <0.01). The trabecular spacing was significantly larger in group F compared with group M on day 14 (P <0.05).
  
  
  CONCLUSIONS
  Fluoxetine did not interfere with induced tooth movement or trabecular bone in rats.
authors: Postgraduate student, Graduate Program in Dentistry, Orthodontics, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
authors: Giovana Carla
authors: GC
authors: Franzon Frigotto
authors: Postgraduate student, Graduate Program in Dentistry, Orthodontics, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
authors: Cristiano
authors: C
authors: Miranda de Araujo
authors: Professor, Graduate Program in Dentistry, Orthodontics, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
authors: Odilon
authors: O
authors: Guariza Filho
authors: Professor, Graduate Program in Dentistry, Orthodontics, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
authors: Orlando Motohiro
authors: OM
authors: Tanaka
authors: Professor, Graduate Program in Dentistry, Histopathology, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
authors: Aline Cristina
authors: AC
authors: Batista Rodrigues Johann
authors: Professor, Graduate Program in Dentistry, Orthodontics, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil. Electronic address: escamargo@uol.com.br.
authors: Elisa Souza
authors: ES
authors: Camargoa
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000097:blood / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects; D002452:Cell Count; D003094:Collagen / Q000187:drug effects; D005269:Femur / Q000187:drug effects; D005473:Fluoxetine / Q000097:blood / Q000494:pharmacology*; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008437:Maxilla / Q000187:drug effects; D008859:Microscopy, Polarization; D008963:Molar / Q000187:drug effects; D009969:Orthodontic Wires; D010010:Osteoclasts / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000071681:Tartrate-Resistant Acid Phosphatase; D013997:Time Factors; D014087:Tooth Movement Techniques / Q000295:instrumentation / Q000379:methods*; D055114:X-Ray Microtomography / Q000379:methods
chemical_list: D018687:Antidepressive Agents, Second-Generation; D007527:Isoenzymes; D005473:Fluoxetine; D003094:Collagen; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase