title: Not Calm and Aminoff Suffering Syndrome in Advanced Alzheimer's Disease.
abstract: We studied 183 patients with advanced dementia who had been admitted to the Geriatric-Internal Medicine Department of a general hospital, with a 1 year follow-up evaluated by Mini-Suffering State Examination (MSSE) scores on first days after admission. The not calm compared to calm patients with advanced dementia had a high suffering level (6.12 ± 2.16 versus 3.21 ± 1.71) with a statistically significant difference (P = 0.001). The not calm patients were sicker, a higher percentage had fever (P = 0.005), elevated levels of white blood cells WBC (P = 0.003) and C-reactive protein (CRP) (P = 0.020). The Kaplan-Meier function analysis showed a shorter survival of not calm versus calm advanced dementia patients, with a statistically significant difference (Log Rank [Mantel-Cox] P = 0.002). Not calm in advanced dementia patients is the first item of the MSSE and is a very important symptom of Aminoff Suffering Syndrome.
authors: The Minerva Center for the Interdisciplinary Study of End-of-Life, Tel Aviv University, Ramat Aviv, Israel Geriatric Division, The Chaim Sheba Medical Center, Tel Hashomer, Israel bechorz@yahoo.com.
authors: Bechor Zvi
authors: BZ
authors: Aminoff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000145:classification / Q000523:psychology*; D010054:Brief Psychiatric Rating Scale; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006760:Hospitalization; D006801:Humans; D053208:Kaplan-Meier Estimate; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000209:etiology*; D013577:Syndrome
chemical_list: D002097:C-Reactive Protein
keywords: Aminoff suffering syndrome; advanced dementia; end of life; not calm