title: Polymicrobial Candida biofilms: friends and foe in the oral cavity.
abstract: The role of polymicrobial biofilm infections in medicine is becoming more apparent. Increasing number of microbiome studies and deep sequencing has enabled us to develop a greater understanding of how positive and negative microbial interactions influence disease outcomes. An environment where this is particularly pertinent is within the oral cavity, a rich and diverse ecosystem inhabited by both bacteria and yeasts, which collectively occupy and coexist within various niches as biofilm communities. Studies within this environment have however tended to be subject to extensive independent investigation, in the context of either polymicrobial bacterial communities or yeast biofilms, but rarely both together. It is clear however that they are not mutually exclusive. Therefore, this review aims to explore the influence of candidal populations on the composition of these complex aggregates and biofilm communities, to investigate their mechanistic interactions to understand how these impact clinical outcomes, and determine whether we can translate how this knowledge can be used to improve patient management.
authors: Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UK.
authors: Lindsay E
authors: LE
authors: O'Donnell
authors: Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UK.
authors: Emma
authors: E
authors: Millhouse
authors: Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UK.
authors: Leighann
authors: L
authors: Sherry
authors: Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UK.
authors: Ryan
authors: R
authors: Kean
authors: Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UK.
authors: Jennifer
authors: J
authors: Malcolm
authors: Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UK.
authors: Christopher J
authors: CJ
authors: Nile
authors: Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UK gordon.ramage@glasgow.ac.uk.
authors: Gordon
authors: G
authors: Ramage
mesh_terms: D000818:Animals; D001419:Bacteria / Q000254:growth & development*; D018407:Bacterial Physiological Phenomena; D018441:Biofilms / Q000254:growth & development*; D002175:Candida / Q000254:growth & development / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D056265:Microbial Interactions; D023421:Models, Animal; D009055:Mouth / Q000382:microbiology*; D013559:Symbiosis
keywords: Candida; biofilm; polymicrobial