title: Integrating Multiple On-line Knowledge Bases for Disease-Lab Test Relation Extraction.
abstract: A computable knowledge base containing relations between diseases and lab tests would be a great resource for many biomedical informatics applications. This paper describes our initial step towards establishing a comprehensive knowledge base of disease and lab tests relations utilizing three public on-line resources. LabTestsOnline, MedlinePlus and Wikipedia are integrated to create a freely available, computable disease-lab test knowledgebase. Disease and lab test concepts are identified using MetaMap and relations between diseases and lab tests are determined based on source-specific rules. Experimental results demonstrate a high precision for relation extraction, with Wikipedia achieving the highest precision of 87%. Combining the three sources reached a recall of 51.40%, when compared with a subset of disease-lab test relations extracted from a reference book. Moreover, we found additional disease-lab test relations from on-line resources, indicating they are complementary to existing reference books for building a comprehensive disease and lab test relation knowledge base.
authors: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Yaoyun
authors: Y
authors: Zhang
authors: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Ergin
authors: E
authors: Soysal
authors: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Sungrim
authors: S
authors: Moon
authors: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Jingqi
authors: J
authors: Wang
authors: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Cui
authors: C
authors: Tao
authors: School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Hua
authors: H
authors: Xu