title: The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature.
abstract: The discovery of α-synuclein (α-syn) as a major component of Lewy bodies, neuropathological hallmark of Parkinson's disease (PD), dementia with Lewy bodies and of glial inclusions in multiple system atrophy initiated the investigation of α-syn as a biomarker in cerebrospinal fluid (CSF). Due to the involvement of the periphery in PD the quantification of α-syn in peripheral fluids such as serum, plasma and saliva has been investigated as well. We review how the development of multiple assays for the quantification of α-syn has yielded novel insights into the variety of α-syn species present in the different fluids; the optimal preanalytical conditions required for robust quantification and the potential clinical value of α-syn as biomarker. We also suggest future approaches to use of CSF α-syn in neurodegenerative diseases.
authors: Memory Disorders Research Group, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors: Anja Hviid
authors: AH
authors: Simonsen
authors: Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition & Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Bea
authors: B
authors: Kuiperij
authors: College of Science and Engineering, Hamid Bin Khalifa University, Qatar Foundation, Education City, PO Box 5825 Doha, Qatar.
authors: Omar Mukhtar Ali
authors: OM
authors: El-Agnaf
authors: Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp & Department of Neurology & Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium.
authors: Sebastian
authors: S
authors: Engelborghs
authors: Institute of Clinical Medicine - Neurology University of Eastern Finland School of Medicine, Kuopio, Finland.
authors: Sanna-Kaisa
authors: SK
authors: Herukka
authors: Centro Disturbi della Memoria- Unità Valutativa Alzheimer, Clinica Neurologica, Università di Perugia, Italy.
authors: Lucilla
authors: L
authors: Parnetti
authors: Applied Neuroscience Research Group, CEITEC MU, Masaryk University, Brno, Czech Republic.
authors: Irena
authors: I
authors: Rektorova
authors: ADx NeuroSciences, VIB-Bioincubator, Technologiepark Zwijnaarde 4, 9052 Ghent, Belgium.
authors: Eugeen
authors: E
authors: Vanmechelen
authors: National & Kapodistrian University of Athens, School of Medicine, 1st Department of Neurology, Eginition Hospital, Athens, Greece.
authors: Elisabeth
authors: E
authors: Kapaki
authors: Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition & Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Marcel
authors: M
authors: Verbeek
authors: Paracelsus-Elena-Klinik, Kassel & University Medical Center (Departments of Neuropathology & Neurosurgery), Georg-August University Goettingen, Germany.
authors: Brit
authors: B
authors: Mollenhauer
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000134:cerebrospinal fluid; D019963:Clinical Chemistry Tests; D006801:Humans; D019636:Neurodegenerative Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000235:genetics; D051844:alpha-Synuclein / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D051844:alpha-Synuclein
keywords: CSF; ELISA; Parkinson's disease; biomarker; diagnosis; α-synuclein