title: Vigabatrin-induced MRI changes associated with extrapyramidal symptoms in a child with infantile spasms.
abstract: Vigabatrin is an antiepileptic drug used for treatment of infantile spasms. We present a female patient with infantile spasms in treatment with vigabatrin who developed ataxic movements. MRI demonstrated a symmetrical pattern of thalamic and globi pallidi diffusion restriction. While these image features have been widely described to be related to the use of vigabatrin, this case highlights the development of movement disorders in association with MRI signal changes. Awareness of the reversible nature of this condition is reassuring for the treating team and avoids unjustified studies.
authors: Radiology Department, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Chile vschonstedt@alemana.cl.
authors: Valeria
authors: V
authors: Schonstedt
authors: Radiology Department, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Chile.
authors: Ximena
authors: X
authors: Stecher
authors: Pediatric Neurology Department, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Chile.
authors: Viviana
authors: V
authors: Venegas
authors: Radiology Department, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Chile.
authors: Claudio
authors: C
authors: Silva
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D001259:Ataxia / Q000139:chemically induced*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D013036:Spasms, Infantile / Q000188:drug therapy*; D020888:Vigabatrin / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D020888:Vigabatrin
keywords: Vigabatrin; ataxic movements; infantile spasms; magnetic resonance imaging