title: [Distribution of CD45RO⁺ T and CD45RA⁺ T Cells in Peripheral Blood of Patients with Peripheral T Cell Lymphoma].
abstract: OBJECTIVE
  To investigate the clinical significance of memory T cells (CD45RO⁺ T) and the initial T cells (CD45RA⁺ T) distribution in peripheral blood of patients with peripheral T-cell lymphoma (PTCL).
  
  
  METHODS
  A total of 27 patients diagnosed as PTCL in our hospital from February 2010 to February 2014 were collected in this study; whereas 30 healthy people were enrolled as control. The distribution of CD45RO⁺ T and CD45RA⁺ T cells were detected seperately in each group, and the results were analysed further.
  
  
  RESULTS
  The expression of T cell antigens in lymphnodes of PTCL patients were diverse: the CD4⁺ T cells were the main immune phenotype, while the B cell-related antigen was not expressed. The CD4⁺/CD8⁺, CD4⁺ CD45RO⁺ T in the peripheral blood of PTCL patients were significantly lower than that in normal group (P < 0.05); while the CD4, CD45RA⁺ T, CD8⁺ CD45RA⁺ T and CD8⁺ CD45RO⁺ T were significantly higher than that in normal group (P < 0.05). The patients in stage I/II had higher CD4⁺/CD8⁺, CD4⁺ CD45RO⁺ T than those in stage III/IV (P < 0.05), whereas the CD4⁺ CD45RA⁺ T, CD8⁺ CD45RA⁺ T and CD8⁺ CD45RO⁺ T were significantly lower than those in the stage III/IV patients (P < 0.05).
  
  
  CONCLUSIONS
  The distributions of CD45RA⁺ T and CD45RO⁺ T in PTCL patients are quite different, and the corresponding treatment might be adopted according to the different distribution of these cells, so as to improve the diagnosis and prognosis of PTCL.
authors: Department of Oncology and Hematology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
authors: Xin-Yan
authors: XY
authors: Jia
authors: Department of Oncology and Hematology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China . E-mail: jiaxinyan100@163.com.
authors: Wen-Zhong
authors: WZ
authors: Yang
authors: Department of Oncology and Hematology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
authors: Yang
authors: Y
authors: Su
authors: Department of Oncology and Hematology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
authors: Qi
authors: Q
authors: Li
mesh_terms: D015496:CD4-Positive T-Lymphocytes; D006801:Humans; D017493:Leukocyte Common Antigens; D016411:Lymphoma, T-Cell, Peripheral; D010641:Phenotype; D011379:Prognosis
chemical_list: D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human