title: Clinical outcome of titanium-nitride-oxide-coated cobalt-chromium stents in patients with de novo coronary lesions: 12-month results of the OPTIMAX first-in-man study.
abstract: OBJECTIVE
  We explored the 12-month clinical outcome of the titanium-nitride-oxide-coated OPTIMAX stent based on cobalt-chromium platform.
  
  
  BACKGROUND
  The OPTIMAX stent demonstrated a satisfactory 6-month clinical outcome in de novo coronary lesions.
  
  
  METHODS
  We enrolled 224 consecutive symptomatic patients with significant (50%) stenosis in de novo coronary lesions, who were treated with OPTIMAX stent implantation. The primary endpoint was major adverse cardiac events at 12-month follow-up, defined as a composite of cardiac death, non-fatal myocardial infarction (MI), or ischemia-driven target lesion revascularization (TLR). Stent thrombosis was adjudicated according to the definition of the Academic Research Consortium.
  
  
  RESULTS
  The mean age of the cohort was 67 ± 8 years (75% males). Patients presented with acute coronary syndrome in 62.1%. Radial access was used in 92%; complex (type B and C) lesions were treated in 79.9%. Both procedural and clinical success occurred in 100% of the cases. The mean follow-up period was 366 ± 22 days. At 12-month follow-up, the primary endpoint occurred in 14 (6.3%) patients. Cardiac death occurred in three (1.3%) patients, non-fatal MI in seven (3.1%) patients, and ischemia-driven TLR in seven (3.1%) patients. No definite stent thrombosis occurred.
  
  
  CONCLUSIONS
  In the current prospective observational study, implantation of the OPTIMAX stent demonstrated an adequate 12-month clinical outcome, with a low rate of major adverse cardiac events, and no stent thrombosis.
authors: Heart Center, Satakunta Central Hospital, Pori, Finland.
authors: Pasi P
authors: PP
authors: Karjalainen
authors: Heart Center, Satakunta Central Hospital, Pori, Finland.
authors: Jussi
authors: J
authors: Mikkelsson
authors: Heart Center, Satakunta Central Hospital, Pori, Finland.
authors: Tuomas
authors: T
authors: Paana
authors: Heart Center, Satakunta Central Hospital, Pori, Finland.
authors: Wail
authors: W
authors: Nammas
mesh_terms: D000368:Aged; D002858:Chromium Alloys; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D003328:Coronary Thrombosis / Q000209:etiology / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality; D010087:Oxides; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D011446:Prospective Studies; D011474:Prosthesis Design; D012307:Risk Factors; D015607:Stents; D013997:Time Factors; D014025:Titanium; D016896:Treatment Outcome
chemical_list: D002858:Chromium Alloys; D020099:Coated Materials, Biocompatible; D010087:Oxides; C041500:titanium nitride; D014025:Titanium
keywords: cobalt-chromium; percutaneous coronary intervention; stent thrombosis; titanium-nitride-oxide