title: Comparison of two methods for selegiline determination: A flow-injection chemiluminescence method using cadmium sulfide quantum dots and corona discharge ion mobility spectrometry.
abstract: Two analytical approaches including chemiluminescence (CL) and corona discharge ionization ion mobility spectrometry (CD-IMS) were developed for sensitive determination of selegiline (SG). We found that the CL intensity of the KMnO4-Na2S2O3 CL system was significantly enhanced in the presence of L-cysteine capped CdS quantum dots (QDs). A possible CL mechanism for this CL reaction is proposed. In the presence of SG, the enhanced CL system was inhibited. Based on this inhibition, a simple and sensitive flow-injection CL method was proposed for the determination of SG. Under optimum experimental conditions, the decreased CL intensity was proportional to SG concentration in the range of 0.01 to 30.0 mg L(-1). The detection limit (3σ) was 0.004 mg L(-1). Also, SG was determined using CD-IMS, and under optimum conditions of CD-IMS, calibration curves were linear in the range of 0.15 to 42.0 mg L(-1), with a detection limit (3σ) of 0.03 mg L(-1). The precision of the two methods was calculated by analyzing samples containing 5.0 mg L(-1) of SG (n=11). The relative standard deviations (RSDs%) of the flow-injection CL and CD-IMS methods are 2.17% and 3.83%, respectively. The proposed CL system exhibits a higher sensitivity and precision than the CD-IMS method for the determination of SG.
authors: Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran. Electronic address: a_khataee@tabrizu.ac.ir.
authors: Alireza
authors: A
authors: Khataee
authors: Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran.
authors: Roya
authors: R
authors: Lotfi
authors: Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran.
authors: Aliyeh
authors: A
authors: Hasanzadeh
authors: Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111 Maragheh, Iran.
authors: Mortaza
authors: M
authors: Iranifam
authors: Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran.
authors: Mahmoud
authors: M
authors: Zarei
authors: School of Mechanical Engineering, Yeungnam University, 712-749 Gyeongsan, South Korea. Electronic address: swjoo@yu.ac.kr.
authors: Sang Woo
authors: SW
authors: Joo
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003545:Cysteine / Q000737:chemistry; D017022:Flow Injection Analysis / Q000379:methods*; D007477:Ions; D007700:Kinetics; D008163:Luminescent Measurements / Q000379:methods*; D045663:Quantum Dots / Q000737:chemistry* / Q000648:ultrastructure; D012642:Selegiline / Q000032:analysis* / Q000737:chemistry; D013057:Spectrum Analysis / Q000379:methods*; D013440:Sulfides / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D019187:Cadmium Compounds; D007477:Ions; D013440:Sulfides; C034939:cadmium sulfide; D014867:Water; D012642:Selegiline; D003545:Cysteine
keywords: CdS quantum dots; Chemiluminescence; Corona discharge ion mobility spectrometry; Flow injection; Nanocatalyst