title: Nano-enabled delivery of diverse payloads across complex biological barriers.
abstract: Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.
authors: Chemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USA.
authors: Kathleen A
authors: KA
authors: Ross
authors: Chemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USA.
authors: Timothy M
authors: TM
authors: Brenza
authors: Veterinary Microbiology and Preventive Medicine, Iowa State University, 2180 Vet Med, Ames 50011, USA.
authors: Andrea M
authors: AM
authors: Binnebose
authors: Pathobiological Sciences, University of Wisconsin-Madison, 1656 Linden Dr., Madison 53706, USA.
authors: Yashdeep
authors: Y
authors: Phanse
authors: Biomedical Sciences, Iowa State University, 2008 Vet Med, Ames 50011, USA.
authors: Anumantha G
authors: AG
authors: Kanthasamy
authors: Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha 68198, USA.
authors: Howard E
authors: HE
authors: Gendelman
authors: Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, 115 S. Grand Avenue, Iowa City 52242, USA.
authors: Aliasger K
authors: AK
authors: Salem
authors: Pathobiological Sciences, University of Wisconsin-Madison, 1656 Linden Dr., Madison 53706, USA.
authors: Lyric C
authors: LC
authors: Bartholomay
authors: Veterinary Microbiology and Preventive Medicine, Iowa State University, 2180 Vet Med, Ames 50011, USA.
authors: Bryan H
authors: BH
authors: Bellaire
authors: Chemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames 50011, USA. Electronic address: nbalaji@iastate.edu.
authors: Balaji
authors: B
authors: Narasimhan
mesh_terms: D060105:Animal Shells / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D004337:Drug Carriers / Q000008:administration & dosage*; D053758:Nanoparticles / Q000008:administration & dosage*; D009369:Neoplasms / Q000378:metabolism
chemical_list: D004337:Drug Carriers
keywords: Biological barriers; Blood–brain barrier; Drug delivery; Nanoparticle; Tumor microenvironment; Vector-borne disease