title: Effect of Saccharomyces cerevisiae strain UFMG A-905 in experimental model of inflammatory bowel disease.
abstract: In the present study, the protective potential of Saccharomyces cerevisiae strain UFMG A-905 was evaluated in a murine model of acute ulcerative colitis (UC). Six groups of Balb/c mice were used: not treated with yeast and not challenged with dextran sulphate sodium (DSS) (control); treated with S. cerevisiae UFMG A-905 (905); treated with the non-probiotic S. cerevisiae W303 (W303); challenged with DSS (DSS); treated with S. cerevisiae UFMG A-905 and challenged with DSS (905 + DSS); and treated with S. cerevisiae W303 and challenged with DSS (W303 + DSS). Seven days after induction of UC, mice were euthanised to remove colon for enzymatic, immunological, and histopathological analysis. In vivo intestinal permeability was also evaluated. An improvement of clinical manifestations of experimental UC was observed only in mice of the 905 + DSS group when compared to animals from DSS and W303 + DSS groups. This observation was confirmed by histological and morphometrical data and determination of myeloperoxidase and eosinophil peroxidase activities, intestinal permeability and some pro-inflammatory cytokines. S. cerevisiae UFMG A-905 showed to be a potential alternative treatment for UC when used in an experimental animal model of the disease.
authors: 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: F C P
authors: FC
authors: Tiago
authors: 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: B A A
authors: BA
authors: Porto
authors: 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: N S
authors: NS
authors: Ribeiro
authors: 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: L M C
authors: LM
authors: Moreira
authors: 2 Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: R M E
authors: RM
authors: Arantes
authors: 3 Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: A T
authors: AT
authors: Vieira
authors: 3 Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: M M
authors: MM
authors: Teixeira
authors: 4 School of Pharmacy, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: S V
authors: SV
authors: Generoso
authors: 4 School of Pharmacy, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: V N
authors: VN
authors: Nascimento
authors: 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: F S
authors: FS
authors: Martins
authors: 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
authors: J R
authors: JR
authors: Nicoli
mesh_terms: D000818:Animals; D003106:Colon / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D015212:Inflammatory Bowel Diseases / Q000628:therapy*; D008297:Male; D008807:Mice, Inbred BALB C; D019936:Probiotics / Q000008:administration & dosage*; D012441:Saccharomyces cerevisiae / Q000254:growth & development*; D016896:Treatment Outcome
keywords: Saccharomyces cerevisiae; dextran sulphate sodium; inflammatory bowel disease; probiotic; ulcerative colitis