title: Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
abstract: Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland (MG) is the only organ developing predominantly after birth, we utilized it as a powerful system to study adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ (IFNγ)-producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation.
authors: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: vicki.plaks@ucsf.edu.
authors: Vicki
authors: V
authors: Plaks
authors: Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Bijan
authors: B
authors: Boldajipour
authors: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Jelena R
authors: JR
authors: Linnemann
authors: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Nguyen H
authors: NH
authors: Nguyen
authors: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Kelly
authors: K
authors: Kersten
authors: Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
authors: Yochai
authors: Y
authors: Wolf
authors: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Amy-Jo
authors: AJ
authors: Casbon
authors: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Niwen
authors: N
authors: Kong
authors: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Renske J E
authors: RJ
authors: van den Bijgaart
authors: Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Dean
authors: D
authors: Sheppard
authors: Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Andrew C
authors: AC
authors: Melton
authors: Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Matthew F
authors: MF
authors: Krummel
authors: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: zena.werb@ucsf.edu.
authors: Zena
authors: Z
authors: Werb
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D000938:Antigen-Presenting Cells / Q000166:cytology / Q000276:immunology*; D001940:Breast / Q000254:growth & development / Q000276:immunology* / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology* / Q000276:immunology; D004848:Epithelium / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007371:Interferon-gamma / Q000378:metabolism; D051379:Mice; D038081:Organogenesis / Q000276:immunology*
chemical_list: D007371:Interferon-gamma