title: A Short Introduction to Arterial Spin Labeling and its Application to Flow Territory Mapping.
abstract: Arterial spin labeling (ASL) is an emerging method for the assessment of perfusion in various diseases of the brain. In ASL, the magnetization of arterial blood water spins is manipulated in a complete non-invasive way before flowing into the tissue of interest. This allows absolute quantification of cerebral blood flow, thereby, presenting an alternative to contrast-enhanced methods based on computed tomography or magnetic resonance imaging. Furthermore, its potential application for flow territory mapping can provide additional information of the individual configuration of intracerebral blood flow. This article gives a brief overview of the basic ASL methodology and its approaches to image individual perfusion territories. Additionally, the utilization of ASL in a variety of cerebrovascular diseases is presented to provide examples of potential applications of (territorial) ASL in clinical routine.
authors: Clinic for Radiology and Neuroradiology, UKSH Campus Kiel, 24105, Kiel, Arnold-Heller-Straße 3, Germany. Thomas.Lindner@uksh.de.
authors: T
authors: T
authors: Lindner
authors: Philips GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany.
authors: M
authors: M
authors: Helle
authors: Clinic for Radiology and Neuroradiology, UKSH Campus Kiel, 24105, Kiel, Arnold-Heller-Straße 3, Germany.
authors: O
authors: O
authors: Jansen
mesh_terms: D001783:Blood Flow Velocity; D002533:Cerebral Angiography / Q000379:methods; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D013113:Spin Labels
chemical_list: D013113:Spin Labels
keywords: Arterial spin labeling; Flow territory mapping; MRI; Non-contrast enhanced; Perfusion