title: Advances in the Molecular Analysis of Soft Tissue Tumors and Clinical Implications.
abstract: The emergence of high-throughput molecular technologies has accelerated the discovery of novel diagnostic, prognostic and predictive molecular markers. Clinical implementation of these technologies is expected to transform the practice of surgical pathology. In soft tissue tumor pathology, accurate interpretation of comprehensive genomic data provides useful diagnostic and prognostic information, and informs therapeutic decisions. This article reviews recently developed molecular technologies, focusing on their application to the study of soft tissue tumors. Emphasis is made on practical issues relevant to the surgical pathologist. The concept of genomically-informed therapies is presented as an essential motivation to identify targetable molecular alterations in sarcoma.
authors: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: admarino@partners.org.
authors: Adrian
authors: A
authors: Marino-Enriquez
mesh_terms: D023281:Genomics / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods / Q000639:trends; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000639:trends*; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D011379:Prognosis; D012509:Sarcoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
keywords: Molecular diagnostics; Sarcoma; Soft tissue tumor; Targeted therapy