title: Integrated analyses of copy number variations and gene differential expression in lung squamous-cell carcinoma.
abstract: BACKGROUND
  Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and copy number variation (CNV).
  
  
  RESULTS
  A higher burden of the CNVs was found in 10-50 kb length. The 16 CNV-driven genes mainly located in chr 1 and chr 3 were enriched in immune response [e.g. complement factor H (CFH) and Fc fragment of IgG, low affinity IIIa, receptor (FCGR3A)], starch and sucrose metabolism [e.g. amylase alpha 2A (AMY2A)]. Furthermore, 38 TFs were screened for the 9 CNV-driven genes and then the regulatory network was constructed, in which the GATA-binding factor 1, 2, and 3 (GATA1, GATA2, GATA3) jointly regulated the expression of TP63.
  
  
  CONCLUSIONS
  The above CNV-driven genes might be potential contributors to the development of lung SCC.
authors: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. zhaoyyd@163.com.|Department of Respiratory and Critical Care Medicine, Ningxia People's Hospital, Yinchuan, 750011, China. zhaoyyd@163.com.
authors: Zhao
authors: Z
authors: Yang
authors: Department of Respiratory and Critical Care Medicine, Ningxia People's Hospital, Yinchuan, 750011, China. bingzhuanan@126.com.
authors: Bing
authors: B
authors: Zhuan
authors: Department of Respiratory and Critical Care Medicine, Ningxia People's Hospital, Yinchuan, 750011, China. yingyanand@yeah.net.
authors: Ying
authors: Y
authors: Yan
authors: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. siminjjj@126.com.
authors: Simin
authors: S
authors: Jiang
authors: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. taowangtts@163.com.
authors: Tao
authors: T
authors: Wang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D056915:DNA Copy Number Variations; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction