title: Comparison of the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy and laparotomy: a meta-analysis of clinical studies.
abstract: BACKGROUND
  This meta-analysis aimed to evaluate the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy compared with laparotomy.
  
  
  METHODS
  Clinical studies published in English were retrieved from the computerized databases Medline and Embase. A meta-analysis was performed to investigate the differences in the efficacy and safety of laparoscopy versus laparotomy in terms of postoperative complications, lengths of hospital stay, recurrence rates, and disease-free survival times using the random effects model. The studies were independently reviewed by two investigators. Data from the eligible studies were extracted, and the meta-analysis was performed using the Comprehensive Meta-Analysis program, version 2 (CMA-2; Biostat, Englewood, NJ, USA).
  
  
  RESULTS
  A total of 8 studies were included in the analysis. The results showed that laparoscopic surgery was significantly associated with lower rates of complications (OR = 0.433, P = 0.019) and shorter postoperative hospital stays (weighted mean difference [WMD] = -0.974, P < 0.001). There was no significant difference in the rates of recurrence (OR = 0.707, P = 0.521) between patients with apparent early-stage ovarian tumors who were treated using laparoscopy and those who underwent laparotomy. No publication bias was detected.
  
  
  CONCLUSIONS
  Laparoscopic surgery shows favorable prognostic outcomes in terms of postoperative complication rates and postoperative hospital stay durations. Further studies with longer follow-up periods are required to confirm recurrence and survival outcomes after laparoscopic surgery in patients with apparent early-stage ovarian tumors.
authors: Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital,Capital Medical University, #17 Qi He Lou Street, Dongcheng District, Beijing, 100006, China. zyandzm@163.com.
authors: Ying
authors: Y
authors: Zhang
authors: Department of Gynecology and Obstetrics, Kailuan General Hospital, #57 Xinhua East Road, Tangshan, 063000, Hebei, China. jingtuxingzhe@126.com.
authors: Shuying
authors: S
authors: Fan
authors: Department of Obsteric and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, #1 Shuai Fu Yuanx, Dong Cheng　District, Beijing, 100730, China. xiangyang65@gmail.com.
authors: Yang
authors: Y
authors: Xiang
authors: Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital,Capital Medical University, #17 Qi He Lou Street, Dongcheng District, Beijing, 100006, China. lwtgslhy@126.com.
authors: Hua
authors: H
authors: Duan
authors: Department of Medical Oncology, the Central Hospital of Xuzhou, the Cancer Institute of Southeast University, Xuzhou, Jiangsu, 221009, China. xzsonya@sohu.com.
authors: Li
authors: L
authors: Sun
mesh_terms: D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D007813:Laparotomy / Q000379:methods; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D011379:Prognosis; D016896:Treatment Outcome