title: Safety and Efficacy of Low-osmolarity ORS vs. Modified Rehydration Solution for Malnourished Children for Treatment of Children with Severe Acute Malnutrition and Diarrhea: A Randomized Controlled Trial.
abstract: World Health Organization-recommended rehydration solution for malnourished children (ReSoMal) for rehydrating severe acute malnourished children is not available in India. In present study, 110 consecutive children aged 6-59 months with severely acute malnourishment and acute diarrhea were randomized to low-osmolarity oral rehydration solution (ORS) (osmolarity: 245, sodium: 75) with added potassium (20 mmol/l) or modified ReSoMal (osmolarity: 300, sodium: 45). In all, 15.4% of modified ReSoMal group developed hyponatremia as compared with 1.9% in low-osmolarity ORS, but none developed severe hyponatremia or hypernatremia. Both groups had equal number of successful rehydration (52 each). Both types of ORS were effective in correcting hypokalemia and dehydration, but rehydration was achieved in shorter duration with modified ReSoMal.
authors: Department of Pediatrics, Kalawati Saran Children Hospital, New Delhi, 110001 India ruchika2908@gmail.com.
authors: Ruchika
authors: R
authors: Kumar
authors: Department of Pediatrics, Kalawati Saran Children Hospital, New Delhi, 110001 India.
authors: Praveen
authors: P
authors: Kumar
authors: Department of Pediatrics, Kalawati Saran Children Hospital, New Delhi, 110001 India.
authors: S
authors: S
authors: Aneja
authors: Department of Pediatrics, Kalawati Saran Children Hospital, New Delhi, 110001 India.
authors: Virendra
authors: V
authors: Kumar
authors: Department of Pharmacology, Lady Hardinge Medical College, New Delhi, 110001 India.
authors: Harmeet S
authors: HS
authors: Rehan
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D003681:Dehydration / Q000209:etiology / Q000628:therapy; D003967:Diarrhea / Q000150:complications / Q000628:therapy*; D004311:Double-Blind Method; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007010:Hyponatremia / Q000628:therapy; D007194:India; D007223:Infant; D008297:Male; D009994:Osmolar Concentration; D015532:Rehydration Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D000067011:Severe Acute Malnutrition / Q000150:complications / Q000628:therapy*; D012964:Sodium / Q000172:deficiency; D016896:Treatment Outcome
chemical_list: D015532:Rehydration Solutions; D012964:Sodium
keywords: hyponatremia; rehydration; severe acute malnutrition