title: The successful search for genetic loci associated with depression.
abstract: Major depressive disorder is among the leading causes of disease burden and disability, as well as a major public health concern worldwide. Despite its substantial heritability, no robustly replicated genetic risk loci had been found until recently. Now, a new study has identified, and replicated, two variants associated with an increased risk for this disorder. The success of this study appears to lie in the use of low-coverage sequencing, instead of microarrays, and in minimizing phenotypic and genetic heterogeneity.
authors: Instituto de Investigación Biosanitaria ibs, Granada and CIBER en Salud Mental (CIBERSAM), University of Granada, Granada, Spain.|MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
authors: Margarita
authors: M
authors: Rivera
authors: MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK. peter.mcguffin@kcl.ac.uk.
authors: Peter
authors: P
authors: McGuffin
mesh_terms: D003863:Depression / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics*; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans