title: Synthesis of new kojic acid based unnatural α-amino acid derivatives.
abstract: An efficient method for the preparation of kojic acid based α-amino acid derivatives by alkylation of glycinate schiff base with bromokojic acids have been described. Using this method, mono as well as di alkylated kojic acid-amino acid conjugates have been prepared. This is the first synthesis of C-linked kojic acid-amino acid conjugate where kojic acid is directly linked to amino acid through a C-C bond.
authors: Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India; Department of Chemistry, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530045, AP, India.
authors: C
authors: C
authors: Balakrishna
authors: Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India.
authors: Nagaraju
authors: N
authors: Payili
authors: Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India.
authors: Satyanarayana
authors: S
authors: Yennam
authors: Department of Chemistry, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530045, AP, India.
authors: P
authors: P
authors: Uma Devi
authors: Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India. Electronic address: Manoranjan.Behera@gvkbio.com.
authors: Manoranjan
authors: M
authors: Behera
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D011753:Pyrones; C011890:kojic acid
keywords: Alkylation; Glycine; Hybrid molecule; Kojic acid; Unnatural amino acid