title: Bicuspid aortic valve aortopathy in adults: Incidence, etiology, and clinical significance.
abstract: Bicuspid aortic valve is the most common congenital heart defect and is associated with an aortopathy manifested by dilatation of the ascending thoracic aorta. The clinical consequences of this aortopathy are the need for periodic monitoring of aortic diameters, elective prophylactic surgical aortic repair, and the occurrence of aortic dissection or rupture. This review describes the current knowledge of BAV aortopathy in adults, including incidence, pathophysiologic insights into its etiology, contemporary hypothesis-generating observations into its complications, and recommendations for monitoring and intervention.
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA. Electronic address: michelena.hector@mayo.edu.
authors: Hector I
authors: HI
authors: Michelena
authors: Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy.
authors: Alessandro
authors: A
authors: Della Corte
authors: Division of Medical Genetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Siddharth K
authors: SK
authors: Prakash
authors: Division of Medical Genetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Dianna M
authors: DM
authors: Milewicz
authors: Servei de Cardiologia, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors: Artur
authors: A
authors: Evangelista
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
authors: Maurice
authors: M
authors: Enriquez-Sarano
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000002:abnormalities* / Q000473:pathology; D000082882:Bicuspid Aortic Valve Disease; D005260:Female; D006349:Heart Valve Diseases / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged
keywords: Aortic aneurysm; Aortic dissection; Bicuspid aortic valve