title: PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer.
abstract: The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Shixian
authors: S
authors: Lian
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Yebo
authors: Y
authors: Shao
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Houbao
authors: H
authors: Liu
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Junyi
authors: J
authors: He
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Weiqi
authors: W
authors: Lu
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Yong
authors: Y
authors: Zhang
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Ying
authors: Y
authors: Jiang
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Jun
authors: J
authors: Zhu
mesh_terms: D064413:3-Phosphoinositide-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D005706:Gallbladder Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008819:Mice, Nude; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D015398:Signal Transduction; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014162:Transfection; D015854:Up-Regulation
chemical_list: C581727:JunB protein, human; D014157:Transcription Factors; D064413:3-Phosphoinositide-Dependent Protein Kinases; C578562:PDPK1 protein, human
keywords: 3-phosphoinositide-dependent protein kinase 1; JunB; epithelial–mesenchymal transition; invasion; migration