title: Clinical phenotype classification for selective immunoglobulin A deficiency.
abstract: Selective immunoglobulin A deficiency (SIgAD) is the most common predominantly antibody deficiency, with a wide range of presentations from asymptomatic to severe manifestations. Although many studies have investigated different aspects of SIgAD, no study has yet presented a comprehensive classification of this disease. Based on clinical manifestation of patients and various immune abnormalities associated with SIgAD, this group of patients could be classified into five different phenotypes including asymptomatic, minor infectious, allergic, autoimmune and severe phenotypes. This classification aids physicians in identifying patients and in choosing appropriate management and treatment as well as homogenized groups for molecular and genetic studies.
authors: a 1 Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.|b 2 Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Reza
authors: R
authors: Yazdani
authors: a 1 Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: AmirHossein
authors: A
authors: Latif
authors: a 1 Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Firouzeh
authors: F
authors: Tabassomi
authors: a 1 Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.|c 3 Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institutet at the Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors: Hassan
authors: H
authors: Abolhassani
authors: a 1 Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.|d 4 Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.
authors: Gholamreza
authors: G
authors: Azizi
authors: a 1 Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.|e 5 Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors: Nima
authors: N
authors: Rezaei
authors: a 1 Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Asghar
authors: A
authors: Aghamohammadi
mesh_terms: D006801:Humans; D017098:IgA Deficiency / Q000145:classification* / Q000276:immunology* / Q000473:pathology; D010641:Phenotype
keywords: allergic; asymptomatic; autoimmune; classification; minor infectious; selective immunoglobulin A deficiency; severe phenotypes