title: Inhibition of demineralization around the enamel-dentin/restoration interface after dentin pretreatment with TiF4 and self-etching adhesive systems.
abstract: OBJECTIVE
  The objective of this study was to evaluate the inhibition of demineralization around enamel-dentin/restoration interface after dentin pretreatment with 2.5% titanium tetrafluoride (TiF4).
  
  
  METHODS
  Forty dental class V cavities at the cementoenamel junction were distributed into four groups (n = 10), according to the presence or absence of TiF4 and to the adhesive system (Clearfil SE Bond/CL and Adper EasyOne/AD), and restored with a resin composite. A dynamic pH cycling model was used to induce the development of artificial caries lesions. After sectioning the dental blocks, Knoop microhardness tests were performed at different depths (20, 40, and 60 μm from the occlusal margin of the restoration) and at different distances (100, 200, and 300 μm from the adhesive interface). Repeated measures three-way analysis of variance (ANOVA) and Tukey's test were used (α = 0.05).
  
  
  RESULTS
  For enamel, there were no differences in the microhardness values for CL, AD, and TiF4-AD at depths, regardless of the distances. Considering each depth, there were no significant differences among treatments. For dentin, ANOVA showed no significant interaction among the independent variables treatment*distance*depth (p = 0.994), no significant interaction between treatment*depth (p = 0.722), no significant interaction between treatment*distance (p = 0.265), no significant interaction between depth*distance (p = 0.365), and no significant effect on treatment (p = 0.151), depth (p = 0.067), or distance (p = 0.251).
  
  
  CONCLUSIONS
  Dentin pretreatment of the cavity walls with TiF4 before self-etching adhesive systems was not effective in inhibiting demineralization around the enamel-dentin/restoration interfaces.
  
  
  CONCLUSIONS
  The mechanism of incorporating fluoride in enamel and dentin of the cavity walls to inhibit demineralization around restorations seems ineffective when using TiF4 as a dentin pretreatment.
authors: São Leopoldo Mandic School of Dentistry and Research Institute, Campinas, São Paulo, Brazil.
authors: Enrico Coser
authors: EC
authors: Bridi
authors: São Leopoldo Mandic School of Dentistry and Research Institute, Campinas, São Paulo, Brazil.
authors: Flávia Lucisano Botelho
authors: FL
authors: do Amaral
authors: São Leopoldo Mandic School of Dentistry and Research Institute, Campinas, São Paulo, Brazil.
authors: Fabiana Mantovani Gomes
authors: FM
authors: França
authors: São Leopoldo Mandic School of Dentistry and Research Institute, Campinas, São Paulo, Brazil.
authors: Cecilia Pedroso
authors: CP
authors: Turssi
authors: São Leopoldo Mandic School of Dentistry and Research Institute, Campinas, São Paulo, Brazil. rbasting@yahoo.com.|Departamento de Odontologia Restauradora-Dentística, Faculdade de Odontologia e Instituto de Pesquisas São Leopoldo Mandic, Rua José Rocha Junqueira, 13. Bairro Swift, Campinas, SP, CEP: 13045-755, Brazil. rbasting@yahoo.com.
authors: Roberta Tarkany
authors: RT
authors: Basting
mesh_terms: D000269:Adhesives; D002327:Cariostatic Agents; D003188:Composite Resins; D001840:Dental Bonding; D003743:Dental Enamel; D003804:Dentin; D017220:Dentin-Bonding Agents; D006244:Hardness; D006801:Humans; D019279:Resin Cements
chemical_list: D000269:Adhesives; D002327:Cariostatic Agents; D003188:Composite Resins; D017220:Dentin-Bonding Agents; D019279:Resin Cements
keywords: Demineralization; Microhardness; Self-etching adhesive systems; Titanium tetrafluoride