title: Rare combination of congenital heart disease and pulmonary alveolar proteinosis.
abstract: Here, we describe a case of total anomalous pulmonary venous return with coarctation of the aorta that was diagnosed as pulmonary alveolar proteinosis at autopsy in a male infant. Surgical repair was performed at 1 day of age, but the infant died on postoperative day 51 due to respiratory insufficiency without any evidence of pulmonary venous obstruction. He had been unexpectedly diagnosed with pulmonary alveolar proteinosis and pulmonary hypoplasia on autopsy. Congenital pulmonary alveolar proteinosis is a serious condition with a high mortality rate, which should be considered in the differential diagnosis in patients with a clinical picture of pulmonary venous obstruction, because most patients are unable to survive without proper treatment. In this report, we address specific issues that should be discussed in such cases based on our recent experience.
authors: Department of Pediatric Cardiovascular Surgery, Gunma Children's Medical Center, Shibukawa, Japan.
authors: Yuki
authors: Y
authors: Tanaka
authors: Department of Pediatric Cardiovascular Surgery, Gunma Children's Medical Center, Shibukawa, Japan.
authors: Takashi
authors: T
authors: Miyamoto
authors: Department of Pediatric Cardiovascular Surgery, Gunma Children's Medical Center, Shibukawa, Japan.
authors: Shuichi
authors: S
authors: Yoshitake
authors: Department of Pediatric Cardiovascular Surgery, Gunma Children's Medical Center, Shibukawa, Japan.
authors: Yuji
authors: Y
authors: Naito
authors: Pediatric Cardiology, Gunma Children's Medical Center, Shibukawa, Japan.
authors: Tomio
authors: T
authors: Kobayashi
mesh_terms: D017809:Fatal Outcome; D006330:Heart Defects, Congenital / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications / Q000151:congenital* / Q000175:diagnosis; D013902:Radiography, Thoracic; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000209:etiology*
keywords: congenital heart disease; lung disease; neonate; pulmonary alveolar proteinosis; total anomalous pulmonary venous return