title: Impact of synchrotron radiation-based X-ray phase-contrast tomography on understanding various cardiovascular surgical pathologies.
abstract: At SPring-8, synchrotron radiation-based X-ray phase-contrast tomography (PCXI) has been developed to measure the inner structures of biological soft tissue without destroying them. To resolve the three-dimensional (3D) morphology, we have applied PCXI to various cardiovascular tissue samples, including the thoracic aorta, ductus arteriosus, and cardiac conduction system. In the aortic walls, PCXI demonstrated differences in 3D structures of tunica media of aortic dissection. These findings correlated well with the irregularity of the structure of the media. In the surgically excised sample of coarctation of the aorta, PCXI showed 3D morphological changes in transition from the ductus arteriosus to the descending aorta. PCXI is also useful for examining abnormalities of the cardiac conduction system in congenital heart defects. Synchrotron radiation-based X-ray phase-contrast tomography has strong modality for analyzing 3D morphology and is useful for understanding the pathophysiology of various cardiovascular surgical pathologies.
authors: Division of Cardiovascular Surgery, Japanese Red Cross Kobe Hospital, 1-3-1 Wakihamakaigandori Chuo-ku, Kobe, 651-0073, Japan. t-tsukube@kobe.jrc.or.jp.
authors: Takuro
authors: T
authors: Tsukube
authors: Japan Synchrotron Radiation Research Institute (SPring-8), Sayo, Japan.
authors: Naoto
authors: N
authors: Yagi
authors: Japan Synchrotron Radiation Research Institute (SPring-8), Sayo, Japan.
authors: Masato
authors: M
authors: Hoshino
authors: Division of Pathology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.
authors: Yutaka
authors: Y
authors: Nakashima
authors: Division of Pathophysiological and Experimental Pathology, Kyushu University, Fukuoka, Japan.
authors: Kazunori
authors: K
authors: Nakagawa
authors: Division of Cardiovascular Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan.
authors: Yutaka
authors: Y
authors: Okita
mesh_terms: D001017:Aortic Coarctation / Q000000981:diagnostic imaging; D006348:Cardiac Surgical Procedures; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D015203:Reproducibility of Results; D017356:Synchrotrons; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Aortic dissection; Conduction system; Ductus arteriosus; Phase-contrast tomography; Synchrotron radiation