title: An optical nanoruler based on a conjugated polymer-silver nanoprism pair for label-free protein detection.
abstract: An optical nanoruler system based on a conjugated polyelectrolyte-silver nanoprism pair is developed for label-free protein detection by taking advantage of the metal-enhanced fluorescence effect of silver nanostructures. Antibody-antigen interactions induce a change in the metal-fluorophore distance, followed by the response of a fluorescent signal of the conjugated polyelectrolyte. The system is used to detect target antigens sensitively and selectively.
authors: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.|Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors: Xiaoyu
authors: X
authors: Wang
authors: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors: Shengliang
authors: S
authors: Li
authors: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors: Pengbo
authors: P
authors: Zhang
authors: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors: Fengting
authors: F
authors: Lv
authors: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors: Libing
authors: L
authors: Liu
authors: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
authors: Lidong
authors: L
authors: Li
authors: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors: Shu
authors: S
authors: Wang
mesh_terms: D000941:Antigens / Q000032:analysis*; D004573:Electrolytes / Q000737:chemistry; D004867:Equipment Design; D005453:Fluorescence; D006801:Humans; D061986:MCF-7 Cells / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology; D055096:Optical Devices; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000032:analysis*; D018030:Silver Compounds / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D000941:Antigens; D004573:Electrolytes; D011108:Polymers; D011506:Proteins; D018030:Silver Compounds
keywords: conjugated polyelectrolytes; metal-enhanced fluorescence; protein detection; silver nanoprisms