title: Toxic Assessment of Triclosan and Triclocarban on Artemia salina.
abstract: In this study, we investigated the possible acute toxic and genotoxic effects of triclosan (TCS) and triclocarban (TCC) on Artemia salina. Genotoxicity was evaluated using single-cell gel electrophoresis and apoptotic frequency assays (Annexin V-FITC/PI assay). Acute toxicity test results showed that TCC (LC50-24 h = 17.8 µg/L) was more toxic than TCS (LC50-24 h = 171.1 µg/L). Significant increases in both genotoxic biomarkers were observed at 24 h after initial exposure, indicating that these two chemicals are potentially dangerous for this aquatic biological model. Although further studies are required, a comparison of data both in vitro and in vivo allowed us to suggest possible mechanisms of action for TCS and TCC in this sentinel organism.
authors: College of Biological and Environmental Engineering, Zhejiang Shuren University, 19 Zhoushan East Road, Hangzhou, 310015, Zhejiang, China.|Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China.
authors: Xiaolu
authors: X
authors: Xu
authors: College of Biological and Environmental Engineering, Zhejiang Shuren University, 19 Zhoushan East Road, Hangzhou, 310015, Zhejiang, China. luyin_zjsru@aliyun.com.|Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China. luyin_zjsru@aliyun.com.
authors: Yin
authors: Y
authors: Lu
authors: College of Biological and Environmental Engineering, Zhejiang Shuren University, 19 Zhoushan East Road, Hangzhou, 310015, Zhejiang, China.
authors: Deyong
authors: D
authors: Zhang
authors: Foreign Language College, Zhejiang Shuren University, 19 Zhoushan East Road, Hangzhou, 310015, Zhejiang, China.
authors: Yinyin
authors: Y
authors: Wang
authors: Military Rehabilitation Center, Hangzhou Sanatorium, Nanjing Military Area Command, Hangzhou, 310007, Zhejiang, China.
authors: Xianshan
authors: X
authors: Zhou
authors: College of Biological and Environmental Engineering, Zhejiang Shuren University, 19 Zhoushan East Road, Hangzhou, 310015, Zhejiang, China.
authors: Huiying
authors: H
authors: Xu
authors: College of Biological and Environmental Engineering, Zhejiang Shuren University, 19 Zhoushan East Road, Hangzhou, 310015, Zhejiang, China.
authors: Yu
authors: Y
authors: Mei
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects*; D001681:Biological Assay; D002224:Carbanilides / Q000737:chemistry / Q000633:toxicity*; D020552:Comet Assay; D023382:Toxicity Tests, Acute; D014260:Triclosan / Q000737:chemistry / Q000633:toxicity*
chemical_list: D002224:Carbanilides; D014260:Triclosan; C009540:triclocarban
keywords: Acutetoxicity; Artemia salina; Genotoxicity; Triclocarban; Triclosan