title: Effect of edaravone on serum SP-A and arterial blood gas in patients with lobectomy.
abstract: OBJECTIVE
  To discuss the effect of edaravone on serum pulmonary surfactant protein A (SP-A) and arterial blood gas (ABG) in patients with thoracoscopic lobectomy.
  
  
  METHODS
  40 lung cancer patients with right side of lobectomy were randomly divided into control group (group C, 20 cases) and edaravone group (group E, 20 cases). Group E was treated edaravone (1 mg/kg) between induction and skin incision, dropping within 30 min; group C was treated with equivalent normal saline. The venous and arterial blood were collected in both groups immediately before incision (T0), after 1 h of one-lung ventilation 1 h (T1) and in 1 h after lungs ventilation (T2) for ABG analysis and measurement of serum SP-A level. Results After OLV, serum SP-A levels were significantly increased in both groups (P < 0.05); compared with group C, serum levels of SP-A were reduced (P < 0.05) and ABG was significantly improved in group E.
  
  
  CONCLUSIONS
  Edaravone can reduce serum SP-A levels in patients with lobectomy and alleviate acute lung injury to a certain extent in surgery.
authors: Department of Anesthesiology, The Affiliated Hospital of Qingdao University Qingdao 266000, China.
authors: Li
authors: L
authors: Song
authors: Department of Neurosurgery, Rizhao People's Hospital Rizhao, China.
authors: Feng
authors: F
authors: Xiong
authors: Department of Medicine, The Affiliated Hospital of Qingdao University Qingdao 266000, China.
authors: Xue-Juan
authors: XJ
authors: Zhang
authors: Department of Anesthesiology, The Affiliated Hospital of Qingdao University Qingdao 266000, China.
authors: Wei-Yi
authors: WY
authors: Liu
authors: Department of Anesthesiology, The Affiliated Hospital of Qingdao University Qingdao 266000, China.
authors: Yang
authors: Y
authors: Zhao
authors: Department of Anesthesiology, The Affiliated Hospital of Qingdao University Qingdao 266000, China.
authors: Wei
authors: W
authors: Feng
keywords: ABG analysis; SP-A; edaravone; lung ventilation