title: Novel Equations for Estimating Lean Body Mass in Peritoneal Dialysis Patients.
abstract: ♦
  
  
  OBJECTIVE
  To develop and validate equations for estimating lean body mass (LBM) in peritoneal dialysis (PD) patients. ♦
  
  
  METHODS
  Two equations for estimating LBM, one based on mid-arm muscle circumference (MAMC) and hand grip strength (HGS), i.e., LBM-M-H, and the other based on HGS, i.e., LBM-H, were developed and validated with LBM obtained by dual-energy X-ray absorptiometry (DEXA). The developed equations were compared to LBM estimated from creatinine kinetics (LBM-CK) and anthropometry (LBM-A) in terms of bias, precision, and accuracy. The prognostic values of LBM estimated from the equations in all-cause mortality risk were assessed. ♦
  
  
  RESULTS
  The developed equations incorporated gender, height, weight, and dialysis duration. Compared to LBM-DEXA, the bias of the developed equations was lower than that of LBM-CK and LBM-A. Additionally, LBM-M-H and LBM-H had better accuracy and precision. The prognostic values of LBM in all-cause mortality risk based on LBM-M-H, LBM-H, LBM-CK, and LBM-A were similar. ♦
  
  
  CONCLUSIONS
  Lean body mass estimated by the new equations based on MAMC and HGS was correlated with LBM obtained by DEXA and may serve as practical surrogate markers of LBM in PD patients.
authors: Renal Division, Department of Medicine, Peking University First Hospital Institute of Nephrology, Peking University Key Laboratory of Renal Disease, Ministry of Health of China Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, People's Republic of China dongjie@medmail.com.cn.
authors: Jie
authors: J
authors: Dong
authors: Renal Division, Department of Medicine, Peking University First Hospital Institute of Nephrology, Peking University Key Laboratory of Renal Disease, Ministry of Health of China Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, People's Republic of China.
authors: Yan-Jun
authors: YJ
authors: Li
authors: Renal Division, Department of Medicine, Peking University First Hospital Institute of Nephrology, Peking University Key Laboratory of Renal Disease, Ministry of Health of China Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, People's Republic of China.
authors: Rong
authors: R
authors: Xu
authors: Renal Division, Department of Medicine, Peking University First Hospital Institute of Nephrology, Peking University Key Laboratory of Renal Disease, Ministry of Health of China Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, People's Republic of China.
authors: Zhi-Kai
authors: ZK
authors: Yang
authors: Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, People's Republic of China.
authors: Ying-Dong
authors: YD
authors: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D018737:Hand Strength; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal; D010530:Peritoneal Dialysis; D012189:Retrospective Studies
keywords: Lean body mass; anthropometry; creatinine kinetics; dual-energy X-ray absorptiometry; hand grip strength; mid-arm muscle circumference; mortality; peritoneal dialysis