title: The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides.
abstract: Multiple classes of commercially important auxin herbicides have been discovered since the 1940s including the aryloxyacetates (2,4-D, MCPA, dichlorprop, mecoprop, triclopyr, and fluroxypyr), the benzoates (dicamba), the quinoline-2-carboxylates (quinclorac and quinmerac), the pyrimidine-4-carboxylates (aminocyclopyrachlor), and the pyridine-2-carboxylates (picloram, clopyralid, and aminopyralid). In the last 10 years, two novel pyridine-2-carboxylate (or picolinate) herbicides were discovered at Dow AgroSciences. This paper will describe the structure activity relationship study that led to the discovery of the 6-aryl-picolinate herbicides Arylex™ active (2005) and Rinskor™ active (2010). While Arylex was developed primarily for use in cereal crops and Rinskor is still in development primarily for use in rice crops, both herbicides will also be utilized in additional crops.
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States. Electronic address: jbepp@dow.com.
authors: Jeffrey B
authors: JB
authors: Epp
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Anita L
authors: AL
authors: Alexander
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Terry W
authors: TW
authors: Balko
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Ann M
authors: AM
authors: Buysse
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: William K
authors: WK
authors: Brewster
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Kristy
authors: K
authors: Bryan
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: John F
authors: JF
authors: Daeuble
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Stephen C
authors: SC
authors: Fields
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Roger E
authors: RE
authors: Gast
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Renard A
authors: RA
authors: Green
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Nicholas M
authors: NM
authors: Irvine
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: William C
authors: WC
authors: Lo
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Christian T
authors: CT
authors: Lowe
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: James M
authors: JM
authors: Renga
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: John S
authors: JS
authors: Richburg
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: James M
authors: JM
authors: Ruiz
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Norbert M
authors: NM
authors: Satchivi
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Paul R
authors: PR
authors: Schmitzer
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Thomas L
authors: TL
authors: Siddall
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Jeffery D
authors: JD
authors: Webster
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Monte R
authors: MR
authors: Weimer
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Gregory T
authors: GT
authors: Whiteker
authors: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
authors: Carla N
authors: CN
authors: Yerkes
mesh_terms: D055808:Drug Discovery; D002523:Edible Grain / Q000187:drug effects*; D006540:Herbicides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007210:Indoleacetic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012275:Oryza / Q000187:drug effects*; D010846:Picloram / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C000611439:Arylex active; D006540:Herbicides; D007210:Indoleacetic Acids; C000611440:Rinskor active; D010846:Picloram
keywords: 6-Aryl-picolinate; Arylex; Halauxifen; Halauxifen-methyl; Picolinate; Rinskor