title: Radix Bupleuri ameliorates depression by increasing nerve growth factor and brain-derived neurotrophic factor.
abstract: BACKGROUND
  Chinese herb Radix Bupleuri has been regarded effective to improve treatment of depression, but the molecular mechanism remains unknown. Low levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) increase the likelihood of developing the depression. Therefore, we want to know whether Radix Bupleuri affects the levels of these factors.
  
  
  METHODS
  A total 160 hemodialysis patients were diagnosed with depression and randomly assigned to two groups: Radix Bupleuri group (received 1 g root power of Radix Bupleuri in a capsule daily Radix Bupleuri) and control group (receive placebo).
  
  
  RESULTS
  After three-month follow-up, the patients who received Radix Bupleuri had greater improvement in depression symptoms, anxiety symptoms and general functioning via controls after three-month follow-up (P < 0.05). Serum NGF levels were significantly higher in subjects accepted Radix Bupleuris (178.64 ± 52.18 pg/mL) when compared to a control (103.54 ± 31.23 pg/ml) (P < 0.01). Similarly, serum BDNF levels were significantly higher in subjects accepted Radix Bupleuris (1635.26 ± 121.66 pg/ml) when compared to a control (516.38 ± 44.89 pg/ml) (P < 0.01). The serum levels of NGF and BDNF were negatively related with Montgomery-Asberg Depression Rating Scale (MADRS) and positively related with scores of RAND-36 item Health Survey (RAND-36) (P < 0.01).
  
  
  CONCLUSIONS
  Thus, Radix Bupleuri ameliorates the patients with depression by increasing serum levels of NGF and BDNF. Radix Bupleuri should be developed a new drug for the therapy of depression.
authors: Blood Purification Center, First Affiliated Hospital of Dalian Medical University Dalian 116011, China.
authors: Xia
authors: X
authors: Wang
authors: Blood Purification Center, First Affiliated Hospital of Dalian Medical University Dalian 116011, China.
authors: Qing
authors: Q
authors: Feng
authors: Blood Purification Center, First Affiliated Hospital of Dalian Medical University Dalian 116011, China.
authors: Yong
authors: Y
authors: Xiao
authors: Blood Purification Center, First Affiliated Hospital of Dalian Medical University Dalian 116011, China.
authors: Ping
authors: P
authors: Li
keywords: Brain-derived neurotrophic factor; Radix Bupleuri; depression; montgomery-asberg depression rating scale; nerve growth factor