title: Prospective Evaluation of Rapid Antigen Tests for Diagnosis of Respiratory Viral Pathogens.
abstract: Acute respiratory infection is a frequently transmitted illness of concern to doctors and patients. Considering its airborne transmission, early diagnosis of such disease is particularly important. This study explored respiratory viral infections with influenza virus, parainfluenza virus, respiratory syncytial virus, human metapneumovirus, human bocavirus, coronavirus, and other early diagnostic substances as confirmed by literature resources. This study also used the corresponding monoclonal antibodies that were produced with the use of hybridoma technology, which were fixed on the chip after purification, for further serum detection. Using this method, a new technique to simultaneously detect 6 kinds of febrile respiratory viruses in a protein chip was developed. The accuracy rate of this method can be >99.65%. This product is inexpensive and capable of high-precision and high-throughput screening, which are prominent advantages.
authors: Department of Clinical Laboratory, Guangzhou Center for Disease Control and Prevention, Baiyun District, Guangzhou, Guangdong, People's Republic of China.
authors: K
authors: K
authors: Li
authors: Department of Clinical Laboratory, Guangzhou Center for Disease Control and Prevention, Baiyun District, Guangzhou, Guangdong, People's Republic of China.
authors: Z
authors: Z
authors: Bai
authors: Shenzhen Bioeasy Biotechnology Co, No 11 R&D Center, Taohua Yuan Science and Technology Innovation Park, Baoan District, Shenzhen, Guangdong, People's Republic of China.
authors: H
authors: H
authors: Zhu
authors: Department of Clinical Laboratory, Guangzhou Center for Disease Control and Prevention, Baiyun District, Guangzhou, Guangdong, People's Republic of China. Electronic address: dibiaogz@126.com.
authors: B
authors: B
authors: Di
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D004195:Disease Models, Animal; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D011446:Prospective Studies; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000821:virology
chemical_list: D000956:Antigens, Viral