title: Animal models for studying dengue pathogenesis and therapy.
abstract: Development of a suitable animal model for dengue virus disease is critical for understanding pathogenesis and for preclinical testing of antiviral drugs and vaccines. Many laboratory animal models of dengue virus infection have been investigated, but the challenges of recapitulating the complete disease still remain. In this review, we provide a comprehensive coverage of existing models, from man to mouse, with a specific focus on recent advances in mouse models for addressing the mechanistic aspects of severe dengue in humans. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.
authors: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8-College Road, Singapore 169857, Singapore; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors: Kitti Wing Ki
authors: KW
authors: Chan
authors: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8-College Road, Singapore 169857, Singapore. Electronic address: satoru.watanabe@duke-nus.edu.sg.
authors: Satoru
authors: S
authors: Watanabe
authors: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Immunology Programme, Life Science Institute, National University of Singapore, Singapore.
authors: Ranmali
authors: R
authors: Kavishna
authors: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Immunology Programme, Life Science Institute, National University of Singapore, Singapore.
authors: Sylvie
authors: S
authors: Alonso
authors: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8-College Road, Singapore 169857, Singapore; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: subhash.vasudevan@duke-nus.edu.sg.
authors: Subhash G
authors: SG
authors: Vasudevan
mesh_terms: D000818:Animals; D003715:Dengue / Q000188:drug therapy* / Q000821:virology*; D003716:Dengue Virus / Q000472:pathogenicity*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods
keywords: AG129 mice; Animal models; Antiviral therapy; Dengue; Dengue hemorrhagic fever