title: Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice.
abstract: Ulcerative colitis is a major inflammatory bowel disease (IBD), characterized by inflammation within the gastrointestinal tract through chronic or relapsing immune system activation. The aim of this study is to investigate the potential protective effect of oat β-glucan (βG) against colitis induced by DSS in mice. Eighty mice were randomly divided into the control group (no DSS, no βG), DSS group (DSS only), DSS + L-βG group (DSS plus 500 mg per kg βG), and DSS + H-βG group (DSS plus 1000 mg per kg βG). Compared with the DSS group, administration of βG significantly reduced clinical symptoms with less weight loss, diarrhea and shortening of the colon, the severity of colitis was significantly inhibited as evidenced by the reduced disease activity index (DAI) and degree of histological damage in colon. Moreover, treatment with βG not only decreased myeloperoxidase activity (MPO), and nitric oxide (NO) and malondialdehyde (MDA) levels, but also inhibited mRNA and protein expression of pro-inflammatory factors such as TNF-α, IL-1β, IL-6 and iNOS. This suggests that oat βG in diet might exhibit an anti-inflammatory function against colitis through inhibition of expression of pro-inflammatory factors.
authors: Department of Molecular Nutrition, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, PR China. luofeijun@hotmail.com linql0403@126.com.
authors: Bo
authors: B
authors: Liu
authors: Qinlu
authors: Q
authors: Lin
authors: Tao
authors: T
authors: Yang
authors: Linna
authors: L
authors: Zeng
authors: Limin
authors: L
authors: Shi
authors: Yaya
authors: Y
authors: Chen
authors: Feijun
authors: F
authors: Luo
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D018554:Avena / Q000737:chemistry*; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D003106:Colon / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D016264:Dextran Sulfate; D003967:Diarrhea / Q000517:prevention & control; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D008517:Phytotherapy; D020011:Protective Agents / Q000008:administration & dosage*; D012333:RNA, Messenger / Q000378:metabolism; D011897:Random Allocation; D013154:Spleen / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects; D047071:beta-Glucans / Q000008:administration & dosage*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D020011:Protective Agents; D012333:RNA, Messenger; D047071:beta-Glucans; D009569:Nitric Oxide; D008315:Malondialdehyde; D016264:Dextran Sulfate; D009195:Peroxidase