title: CVD Growth of Graphene on NiTi Alloy for Enhanced Biological Activity.
abstract: From the perspective of surface modification of biomaterials, graphene is very promising because of its unique physical and chemical properties. Herein, we report direct in situ fabrication of graphene on nitinol (NiTi) shape memory alloy by chemical vapor deposition (CVD) and investigate both the growth mechanism as well as surface bioactivity of the modified alloy. Growth of the graphene layer is independent of Ni but is rather correlated with the formation of the TiC phase on the surface. Graphene nucleates and grows on this carbide layer during exposure to CH4. The graphene layer is observed to promote the osteogenesis differentiation of mesenchymal stem cells and surface bioactivity. The use of graphene as a bioactive layer is a viable approach to improving the surface properties of NiTi-based dental and orthopedic implants and components.
authors: University of Chinese Academy of Sciences , Beijing 100049, China.
authors: Jinhua
authors: J
authors: Li
authors: School of Physical Science and Technology, Lanzhou University , Lanzhou 730000, China.
authors: Gang
authors: G
authors: Wang
authors: University of Chinese Academy of Sciences , Beijing 100049, China.
authors: Hao
authors: H
authors: Geng
authors: Hongqin
authors: H
authors: Zhu
authors: Miao
authors: M
authors: Zhang
authors: Zengfeng
authors: Z
authors: Di
authors: Xuanyong
authors: X
authors: Liu
authors: Department of Physics and Materials Science, City University of Hong Kong , Tat Chee Avenue, Kowloon, Hong Kong China.
authors: Paul K
authors: PK
authors: Chu
authors: Xi
authors: X
authors: Wang
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000166:cytology; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D005740:Gases / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D008697:Methane / Q000737:chemistry; D010012:Osteogenesis / Q000187:drug effects; D051381:Rats; D013499:Surface Properties
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D005740:Gases; C013616:nitinol; D006108:Graphite; D008697:Methane
keywords: bioactivity; graphene; nitinol; stem cells; surface and interface