title: Commentary: Participation of Sox-1 Expression and Signaling of β-Catenin in the Pathophysiology of Generalized Seizures in Cerebellum of Rat.
abstract: Epilepsy is one of the most common neurological disorders in humans, and the role of cerebellum in its physiopathology remains the subject of study. Bergmann glia in the cerebellar cortex regulates the homeostasis of Purkinje cells, the axons of which target the dentate and interpositus nuclei, which form the main cerebellar output to other structures in the central nervous system involved in Epilepsy. Sox-1 is a transcription factor expressed in Bergmann glia and its binding to β-Catenin further inhibits the Wnt pathway. β-Catenin is widely expressed in cerebellum. It has been reported that β-Catenin signaling is increased as the hippocampus receives repeated electrical stimuli and this is related with apoptosis of neurons. In the cerebellum, the recurrence of seizures results in Purkinje cells death, although the mechanisms remain unclear.
authors: Artemio
authors: A
authors: Rosiles
authors: Carmen
authors: C
authors: Rubio
authors: Cristina
authors: C
authors: Trejo
authors: Jessica
authors: J
authors: Gutierrez
authors: Leonardo
authors: L
authors: Hernández
authors: Instituto Nacional de Neurología y Neurocirugía, M. V. S. Insurgentes sur 3867 col. La fama México 14269, D.F. México. macaru4@yahoo.com.mx.
authors: Carlos
authors: C
authors: Paz
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000378:metabolism* / Q000503:physiopathology; D005786:Gene Expression Regulation; D006801:Humans; D051381:Rats; D055748:SOXB1 Transcription Factors / Q000096:biosynthesis*; D012640:Seizures / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000096:biosynthesis*
chemical_list: C495268:Ctnnb1 protein, rat; D055748:SOXB1 Transcription Factors; C490908:Sox1 protein, rat; D051176:beta Catenin