title: Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe(3+) in Cancer Stem Cells.
abstract: A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe(3+) detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 μM are demonstrated as a Fe(3+) turn-on fluorescent nanosensor in cancer stem cells. Fe(3+) binding to such GQDs (RBD-GQDs-Fe(3+)) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.
authors: Department of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors: Ruihua
authors: R
authors: Guo
authors: Department of Cell Biology, School of Basic Medicine, Peking University Health Science Center , Beijing 100191, P. R. China.
authors: Shixin
authors: S
authors: Zhou
authors: Department of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors: Yunchao
authors: Y
authors: Li
authors: Department of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors: Xiaohong
authors: X
authors: Li
authors: Department of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors: Louzhen
authors: L
authors: Fan
authors: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors: Nicolas H
authors: NH
authors: Voelcker
mesh_terms: D017209:Apoptosis; D001672:Biocompatible Materials / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D002470:Cell Survival; D016503:Drug Delivery Systems; D004563:Electrochemistry / Q000379:methods; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007501:Iron / Q000737:chemistry*; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000473:pathology; D010777:Photochemistry; D045663:Quantum Dots; D012235:Rhodamines / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D014408:Biomarkers, Tumor; D012235:Rhodamines; D014867:Water; D006108:Graphite; D007501:Iron; C029773:rhodamine B
keywords: Fe3+; cancer stem cells; detection; graphene quantum dots; rhodamine B derivative