title: [Deep vein thrombosis due to protein C deficiency in a neonate].
abstract: BACKGROUND
  Venous thromboembolic disease is increasingly recognized as an important cause of morbidity and mortality in children. In the neonatal period, thrombotic accidents suggest constitutional abnormalities of homeostasis, including congenital protein C deficiency. We report on a clinical case that helps review all the diagnostic elements and discuss actions to be taken in the neonatal period.
  
  
  METHODS
  A newborn infant was admitted for transient neonatal respiratory distress. The physical examination revealed a facial dysmorphism and a bilateral lumbar contact. Abdominal Doppler ultrasounds showed a thrombosis of the vena cava inferior and of the left renal vein. Investigations searching for a thrombophilic state revealed severe congenital protein C deficiency. The maternal level of protein C at 50% argues in favor of a heterozygote deficit, the rate being normal in the father. Therapeutic management was based on low-molecular-weight heparin. The ultrasound check showed regression and then disappearance of thrombosis. Genetic counseling was planned.
  
  
  CONCLUSIONS
  In cases of neonatal thrombosis, seeking a deficiency anticoagulant factor, in particular of protein C, is essential in the newborn and in both parents. Therapeutic management is not codified. An individualized approach is appropriate in this very rare clinical situation.
authors: Service de médecine et réanimation néonatales, centre national de néonatologie et nutrition, hôpital d'Enfants, centre hospitalier Ibn-Sina, boulevard Ibn-Rochd, Souissi 10100, Rabat, Maroc.
authors: H
authors: H
authors: Rahal
authors: Service de médecine et réanimation néonatales, centre national de néonatologie et nutrition, hôpital d'Enfants, centre hospitalier Ibn-Sina, boulevard Ibn-Rochd, Souissi 10100, Rabat, Maroc.
authors: M A
authors: MA
authors: Radouani
authors: Service de médecine et réanimation néonatales, centre national de néonatologie et nutrition, hôpital d'Enfants, centre hospitalier Ibn-Sina, boulevard Ibn-Rochd, Souissi 10100, Rabat, Maroc; Équipe de recherche en santé et nutrition du couple mère-enfant, faculté de médecine et de pharmacie de Rabat, université Mohammed V, Rabat, Maroc.
authors: H
authors: H
authors: Knouni
authors: Service de médecine et réanimation néonatales, centre national de néonatologie et nutrition, hôpital d'Enfants, centre hospitalier Ibn-Sina, boulevard Ibn-Rochd, Souissi 10100, Rabat, Maroc; Équipe de recherche en santé et nutrition du couple mère-enfant, faculté de médecine et de pharmacie de Rabat, université Mohammed V, Rabat, Maroc. Electronic address: barakatamina@yahoo.fr.
authors: A
authors: A
authors: Barkat
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020151:Protein C Deficiency / Q000150:complications* / Q000151:congenital / Q000175:diagnosis; D012082:Renal Veins / Q000000981:diagnostic imaging; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications; D014463:Ultrasonography; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging; D020246:Venous Thrombosis / Q000209:etiology*