title: Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer.
abstract: The SLITRK1 (Slit and Trk-like 1) gene has been suggested to be a promising candidate for Tourette syndrome (TS) since the first report that identified its two rare variants adjacent to the chromosome inversion in a TS child with inv(13) (q31.1;q33.1). A series of replication studies have been carried out, whereas the role of the gene has not been elucidated. The present study aimed to determine whether the two or novel nonsynonymous variants were identified in Japanese TS patients and carry out an association analysis of the gene in a Japanese population. We did not observe the two or any novel nonsynonymous variants in the gene. In contrast, a significant difference was observed in the distributions of the haplotypes consisting of rs9546538, rs9531520, and rs9593835 between the patients and the controls. This result may partially support the implication of SLITRK1 in the pathogenesis of TS, warranting further studies of the gene.
authors: aDepartment of Child Neuropsychiatry bDepartment of Neuropsychiatry, Graduate School of Medicine cDepartment of Physical and Health Education, Graduate School of Education dDisability Services Office eOffice for Mental Health Support, University of Tokyo fDepartment of Neuropsychiatry, Teikyo University School of Medicine, Tokyo, Japan.
authors: Aya
authors: A
authors: Inai
authors: Mamoru
authors: M
authors: Tochigi
authors: Hitoshi
authors: H
authors: Kuwabara
authors: Fumichika
authors: F
authors: Nishimura
authors: Kayoko
authors: K
authors: Kato
authors: Yosuke
authors: Y
authors: Eriguchi
authors: Takafumi
authors: T
authors: Shimada
authors: Masaomi
authors: M
authors: Furukawa
authors: Yoshiya
authors: Y
authors: Kawamura
authors: Tsukasa
authors: T
authors: Sasaki
authors: Chihiro
authors: C
authors: Kakiuchi
authors: Kiyoto
authors: K
authors: Kasai
authors: Yukiko
authors: Y
authors: Kano
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D005879:Tourette Syndrome / Q000453:epidemiology / Q000235:genetics*; D055815:Young Adult
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C505093:SLITRK1 protein, human