title: ROLE OF PARENTERAL NUTRITION IN ONCOLOGIC PATIENTS WITH INTESTINAL OCCLUSION AND PERITONEAL CARCINOMATOSIS.
abstract: OBJECTIVE
  the precise role of parenteral nutrition in the management of oncologic patients with intestinal occlusion is not well defined yet. We aimed to identify the effects of parenteral nutrition in these patients regarding prognosis.
  
  
  METHODS
  55 patients with intestinal occlusion and peritoneal carcinomatosis were included. Parenteral nutrition aimed at 20-35 kcal/Kg/day, and 1.0 g/kg/day of amino-acids. Weight, body mass index, type of tumor, type of chemotherapy, and ECOG among others were recorded and analyzed.
  
  
  RESULTS
  69.1% of the patients had gastrointestinal tumors, 18.2% gynecologic and 12.7% others. Age was 60 ± 13y, baseline ECOG 1.5 ± 0.5 and body mass index 21.6 ± 4.3. Malnutrition was present in 85%. Survival from the start of parenteral nutrition was not significant when considering baseline ECOG (log rank = 0.593, p = 0.743), previous lines of chemotherapy (log rank = 2.117, p = 0.548), baseline BMI (log rank = 2.686, p = 0.261), or type of tumor (log rank = 2.066, p = 0.356). Survival in patients who received home parenteral nutrition after hospital discharge was higher than those who stayed in-hospital (log rank = 7.090, p = 0.008). Survival in patients who started chemotherapy during or after parenteral nutrition was higher than those who did not so (log rank = 17.316, p < 0.001). A total of 3.6% of patients presented catheter related infection without affecting survival (log rank = 0.061, p = 0.804).
  
  
  CONCLUSIONS
  Parenteral nutrition in patients with advanced cancer and intestinal occlusion is safe, and in tho se who respond to chemotherapy, further administration of home parenteral nutrition together with chemotherapy may enhance prolonged survival.
authors: Department of Oncology.. joseignacio.botella@salud.madrid.org.
authors: Eva
authors: E
authors: Aría Guerra
authors: Department of Oncology.. joseignacio.botella@salud.madrid.org.
authors: Alfonso
authors: A
authors: Cortés-Salgado
authors: Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal para la Investigación Sanitaria (IRyCIS).. joseignacio.botella@salud.madrid.org.
authors: Raquel
authors: R
authors: Mateo-Lobo
authors: Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal para la Investigación Sanitaria (IRyCIS).. joseignacio.botella@salud.madrid.org.
authors: Lía
authors: L
authors: Nattero
authors: Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal para la Investigación Sanitaria (IRyCIS).. joseignacio.botella@salud.madrid.org.
authors: Javier
authors: J
authors: Riveiro
authors: Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal para la Investigación Sanitaria (IRyCIS).. joseignacio.botella@salud.madrid.org.
authors: Belén
authors: B
authors: Vega-Piñero
authors: Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal para la Investigación Sanitaria (IRyCIS).. joseignacio.botella@salud.madrid.org.
authors: Beatriz
authors: B
authors: Valbuena
authors: Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal para la Investigación Sanitaria (IRyCIS).. joseignacio.botella@salud.madrid.org.
authors: Fátima
authors: F
authors: Carabaña
authors: Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal para la Investigación Sanitaria (IRyCIS).. joseignacio.botella@salud.madrid.org.
authors: Carmen
authors: C
authors: Carrero
authors: Department of Oncology.. joseignacio.botella@salud.madrid.org.
authors: Enrique
authors: E
authors: Grande
authors: Department of Oncology.. joseignacio.botella@salud.madrid.org.
authors: Alfredo
authors: A
authors: Carrato
authors: Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal para la Investigación Sanitaria (IRyCIS). Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid (Spain).. joseignacio.botella@salud.madrid.org.
authors: José Ignacio
authors: JI
authors: Botella-Carretero
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology* / Q000401:mortality / Q000628:therapy*; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000401:mortality / Q000628:therapy*; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000379:methods; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome