title: Synthesis of new oxadiazole, pyrazole and pyrazolin-5-one bearing 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetohydrazide analogs as potential antibacterial and antifungal agents.
abstract: Two series of diversely substituted phenyldiazenyl(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl)3,5-dimethyl-1H-pyrazole 11a-g and phenyldiazenyl-1-(2-(4-methyl-2-oxo-4-chromen-7-yloxy)acetyl)-3-methyl-1H-pyrazol-5(4)H-one 12a-j were synthesized. All these compounds were characterized by IR, NMR, mass spectra and elemental analyses. The compounds were evaluated for their in vitro antibacterial activity against some Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and screened for antifungal activity against A. niger, U. maydis. The compounds showed moderate to very good antibacterial activities.
authors: Department of chemistry, Sri Krishnadevaraya university, Ananthapuramu, 515 003 Andhra Pradesh, India.
authors: M
authors: M
authors: Mahesh
authors: Department of chemistry, Sri Krishnadevaraya university, Ananthapuramu, 515 003 Andhra Pradesh, India.
authors: G
authors: G
authors: Bheemaraju
authors: Department of chemistry, Sri Krishnadevaraya university, Ananthapuramu, 515 003 Andhra Pradesh, India.
authors: G
authors: G
authors: Manjunath
authors: Department of chemistry, Sri Krishnadevaraya university, Ananthapuramu, 515 003 Andhra Pradesh, India. Electronic address: ramanapv54@gmail.com.
authors: P
authors: P
authors: Venkata Ramana
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D047069:Pyrazolones; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D010069:Oxadiazoles; D011720:Pyrazoles; D047069:Pyrazolones
keywords: Acetylacetone; Activités antibactériennes et antifongiques; Acétoacétate d’éthyle; Acétylacétone; Antibacterial and antifungal activities; Azopyrazole; Coumarin; Coumarine; Ethyl acetoacetate; Oxadiazole; Pyrazole