title: Comparison of Autoimmune Thyroid Disease in Patients With Progressive and Stable Vitiligo.
abstract: OBJECTIVE
  Activity of vitiligo has not been considered as a patient selection criteria in previous studies; we decided to compare the presence of elevated thyroid auto-antibodies in patients with progressive and stable vitiligo.
  
  
  METHODS
  Seventy-two patients with vitiligo were examined for thyroid problems and were divided into 2 groups of stable and progressive vitiligo according to their history and physical examination. Anti-thyroid peroxidase antibodies (anti-TPO antibodies), thyroxine (T4), and thyroid stimulating hormone (TSH) levels were assessed for all patients.
  
  
  RESULTS
  Elevated levels of anti-TPO antibodies were observed in 43.7% of the patients with stable vitiligo and in 37.5% of patients with progressive vitiligo, which was not statistically significant (P = .315).
  
  
  CONCLUSIONS
  This study not only confirmed thyroid dysfunction in patients with vitiligo but also showed that there was no difference in thyroid dysfunction and anti-TPO antibody levels in the subgroups of patients with stable or progressive vitiligo.
authors: Cutaneous Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Mohammad Javad
authors: MJ
authors: Yazdanpanah
authors: Health Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Seyed Ali
authors: SA
authors: Seyedi Noghabi
authors: Endocrine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Morteza
authors: M
authors: Taghavi
authors: Departments of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Monavar
authors: M
authors: Afzal Aghaee
authors: Cutaneous Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran zabolinejadng@mums.ac.ir.
authors: Naghmeh
authors: N
authors: Zabolinejad
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D033862:Iron-Binding Proteins / Q000276:immunology*; D008297:Male; D011446:Prospective Studies; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013972:Thyrotropin / Q000276:immunology; D014820:Vitiligo / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D033862:Iron-Binding Proteins; D013972:Thyrotropin; C056658:TPO protein, human; D007453:Iodide Peroxidase
keywords: autoimmune thyroid disorder; progressive vitiligo; stable vitiligo; thyroid autoantibodies