title: [The developmental switch of visual cortex NMDA receptor NR2 subunits and its implications for visual plasticity].
abstract: Many forms of synaptic plasticity require NMDA-type glutamate receptors (NMDAR). These tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits, usually a combination of NR2A and NR2B. In the neonatal visual cortex NR2B-containing NMDAR predominate, after thatvisual experience facilitates a developmental switch in which NR2A levels increase relative to NR2B. In this review, it puts emphasis on the role and the regulation of this shift as well as the effect on synaptic plasticity.
authors: Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Vision Science, Tianjin Eye Hospital, Tianjin 300020, China.
authors: Yatu
authors: Y
authors: Guo
authors: Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Vision Science, Tianjin Eye Hospital, Tianjin 300020, China; Email: zkx4260@vip.163.com.
authors: Kanxing
authors: K
authors: Zhao
mesh_terms: D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D015398:Signal Transduction; D014793:Visual Cortex / Q000378:metabolism*
chemical_list: C120997:NR2A NMDA receptor; C464437:NR3A NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate