title: Modeling strategies to study metabolic pathways in progression to type 1 diabetes--Challenges and opportunities.
abstract: Seroconversion to islet autoimmunity is preceded by metabolic disturbances in children who later progress to overt type 1 diabetes (T1D). The underlying metabolic pathways and the interaction of metabolic and immune system factors involved in progression to the disease are however poorly understood. There is a clear need for mathematical models which capture the temporal and spatial complexity of early pathogenesis of T1D. Here we review the early attempts to model the development of islet autoimmunity and T1D, including the models which emphasize the potential beneficial role of autoimmune response in specific circumstances, such as to 'correct' for the early metabolic disturbances. We also highlight the genome-scale metabolic modeling as a promising new avenue to study metabolism and its interactions with the immune system in T1D.
authors: Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark.
authors: Tijana
authors: T
authors: Marinković
authors: Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland. Electronic address: mtjo@steno.dk.
authors: Matej
authors: M
authors: Orešič
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D053858:Metabolic Networks and Pathways; D055432:Metabolomics; D008954:Models, Biological
keywords: Autoimmunity; Lipidomics; Metabolic modeling; Metabolomics; Type 1 diabetes