title: Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies.
abstract: The hyperinflammatory syndrome hemophagocytic lymphohistiocytosis can occur in the context of malignancies. Malignancy-triggered hemophagocytic lymphohistiocytosis should be regarded separately from hemophagocytic lymphohistiocytosis during chemotherapeutic treatment, which is frequently associated with an infectious trigger. The substantial overlap between the features of hemophagocytic lymphohistiocytosis with features of neoplasms makes its identification difficult when it occurs in malignant conditions. To facilitate recognition and diagnostic workup, and provide guidance regarding the treatment of malignancy-associated hemophagocytic lymphohistiocytosis, consensus recommendations were developed by the Study Group on Hemophagocytic Lymphohistiocytosis Subtypes of the Histiocyte Society, an interdisciplinary group consisting of pediatric and adult hemato-oncologists and immunologists.
authors: Department of Pediatric Hematology and Oncology, University Medical Center Eppendorf, Hamburg, Germany k.lehmberg@uke.de.
authors: Kai
authors: K
authors: Lehmberg
authors: Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors: Kim E
authors: KE
authors: Nichols
authors: Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
authors: Jan-Inge
authors: JI
authors: Henter
authors: Department of Medicine I, Hematology and Stem Cell Transplantation, Hemostasis and Medical Oncology, Elisabethinen Hospital, Linz, Austria.
authors: Michael
authors: M
authors: Girschikofsky
authors: Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
authors: Tatiana
authors: T
authors: Greenwood
authors: Department of Immunology, Cincinnati Children's Hospital, OH, USA.
authors: Michael
authors: M
authors: Jordan
authors: Department of Immunology, Cincinnati Children's Hospital, OH, USA.
authors: Ashish
authors: A
authors: Kumar
authors: Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Vienna, Austria.
authors: Milen
authors: M
authors: Minkov
authors: Klinik für Innere Medizin II, Abt. Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Germany.
authors: Paul
authors: P
authors: La Rosée
authors: Department of Hematology and Oncology, Sick Kids Hospital, Toronto, Canada.
authors: Sheila
authors: S
authors: Weitzman
mesh_terms: D019468:Disease Management; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications*; D009369:Neoplasms / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy*