title: Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit.
abstract: Critical illness is associated with profound sleep disruption. Causality is diverse and includes physiologic, psychological, and environmental factors. There are limited pharmacologic interventions available to treat sleep disturbances in critical illness; however, multidisciplinary strategies that alter the intensive care unit (ICU) environment and cluster care delivery have shown promise in sleep and circadian promotion and delirium reduction. With the appropriate administrative support and involvement of diverse ICU stakeholders, effective strategies could be created, implemented, and maintained to improve sleep disruption in critically ill patients.
authors: Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, TAC-441 South, PO Box 208057, New Haven, CT 06520-8057, USA. Electronic address: melissa.knauert@yale.edu.
authors: Melissa P
authors: MP
authors: Knauert
authors: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.
authors: Jeffrey A
authors: JA
authors: Haspel
authors: Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, TAC-441 South, PO Box 208057, New Haven, CT 06520-8057, USA.
authors: Margaret A
authors: MA
authors: Pisani
mesh_terms: D002940:Circadian Rhythm; D016638:Critical Illness; D003693:Delirium / Q000150:complications*; D006801:Humans; D007362:Intensive Care Units; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000503:physiopathology*
keywords: Circadian misalignment; Circadian rhythm; Critical illness; Delirium; Intensive care unit; Sleep deprivation; Sleep loss