title: Preventing Heart Failure in Inflammatory and Immune Disorders.
abstract: Patients with chronic inflammatory diseases are at increased risk for heart failure due to ischemic heart disease and other causes including heart failure with preserved ejection fraction. Using rheumatoid arthritis and treated HIV infection as two prototypical examples, we review the epidemiology and potential therapies to prevent heart failure in these populations. Particular focus is given to anti-inflammatory therapies including statins and biologic disease modifying drugs. There is also limited evidence for lifestyle changes and blockade of the renin-angiotensin-aldosterone system. We conclude by proposing how a strategy for heart failure prevention, such as the model tested in the Screening To Prevent Heart Failure (STOP-HF) trial, may be adapted to chronic inflammatory disease.
authors: University Hospitals Case Medical Center, Cleveland, OH, USA.
authors: Maya
authors: M
authors: Serhal
authors: University Hospitals Case Medical Center, Cleveland, OH, USA ; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Chris T
authors: CT
authors: Longenecker
keywords: HIV; Heart Failure; Inflammation; Rheumatoid Arthritis