title: The importance of lactic acid in migraines and fibromyalgia.
abstract: BACKGROUND
  Lactic acid is a byproduct of both muscle metabolism and the central nervous system. Changes in metabolism are related to various physiological and pathological conditions. The aim of this study was to determine the relationship between migraine and fibromyalgia with the levels of lactic acid in the blood.
  
  
  METHODS
  We study of 93 patients was divided into five groups: 1) patients with fibromyalgia (n=20); 2) episodic migraine (n=20); 3) chronic migraine (n=20); 4) fibromyalgia and episodic migraine (n= 13); and 5) fibromyalgia and chronic migraine (n=20), and 20 healthy subjects (control group). Blood levels of lactic acid were measured at four different time points: at rest, during aerobic exercise, during anaerobic physical activity and while resting after anaerobic exercise.
  
  
  RESULTS
  Lactic acid increased in all groups during anaerobic physical activity without predominance for either group. During aerobic physical activity, all groups increased lactic acid levels, but the increase was more expressive in the chronic migraine group and the chronic migraine with fibromyalgia group without statistical significance.
  
  
  CONCLUSIONS
  We did not found abnormalities involving the metabolism of lactic acid in episodic and chronic migraine with or without fibromyalgia.
authors: Programa de Pós-Graduação de Medicina Interna e Ciências da Saúde, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.
authors: Guido Assis Cachuba
authors: GA
authors: de Sá Ribeiro
authors: Programa de Pós-Graduação de Medicina Interna e Ciências da Saúde, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil; Neuromuscular/Neurologia, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.
authors: Rosana Hermínia
authors: RH
authors: Scola
authors: Programa de Pós-Graduação de Medicina Interna e Ciências da Saúde, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil; Unidade de Cefaleia/Neurologia, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.
authors: Elcio Juliato
authors: EJ
authors: Piovesan
authors: Cardiologia/Medicina Interna, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.
authors: Darley Rugeri
authors: DR
authors: Wollmann Junior
authors: Reumatologia/Medicina Interna, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.
authors: Eduardo Dos Santos
authors: Edos S
authors: Paiva
authors: Programa de Pós-Graduação de Medicina Interna e Ciências da Saúde, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil; Cardiologia/Medicina Interna, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.
authors: Claudio Leinig Pereira
authors: CL
authors: da Cunha
authors: Programa de Pós-Graduação de Medicina Interna e Ciências da Saúde, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil; Neuromuscular/Neurologia, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil. Electronic address: lineu.werneck@hc.ufpr.br.
authors: Lineu Cesar
authors: LC
authors: Werneck
mesh_terms: D016022:Case-Control Studies; D015444:Exercise; D005356:Fibromyalgia / Q000097:blood*; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008881:Migraine Disorders / Q000097:blood*
chemical_list: D019344:Lactic Acid
keywords: Chronic migraine; Enxaqueca crônica; Enxaqueca episódica; Episodic migraine; Fibromialgia; Fibromyalgia; Lactic acid; Ácido láctico