title: RNA Pol II as a sensor of 5caC.
abstract: Cytosines in genomic DNA come in different flavors. A recent paper published in Nature reveals that an oxidized variety, 5-carboxylcytosine, is recognized by the elongating RNA polymerase, shedding light on the role of DNA oxidation in transcription regulation.
authors: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors: Jian-Huang
authors: JH
authors: Xue
authors: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors: Guo-Liang
authors: GL
authors: Xu
mesh_terms: D003596:Cytosine / Q000031:analogs & derivatives*; D012319:RNA Polymerase II / Q000737:chemistry* / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D061805:Transcription Elongation, Genetic
chemical_list: D003596:Cytosine; D012319:RNA Polymerase II