title: Diffraction-Enhanced Computed Tomographic Imaging of Growing Piglet Joints by Using a Synchrotron Light Source.
abstract: The objective of this project was to develop and test a new technology for imaging growing joints by means of diffraction-enhanced imaging (DEI) combined with CT and using a synchrotron radiation source. DEI-CT images of an explanted 4-wk-old piglet stifle joint were acquired by using a 40-keV beam. The series of scanned slices was later 'stitched' together, forming a 3D dataset. High-resolution DEI-CT images demonstrated fine detail within all joint structures and tissues. Striking detail of vasculature traversing between bone and cartilage, a characteristic of growing but not mature joints, was demonstrated. This report documents for the first time that DEI combined with CT and a synchrotron radiation source can generate more detailed images of intact, growing joints than can currently available conventional imaging modalities.
authors: Department of Biomedical Engineering, Canadian Light Source, Saskatoon, Saskatchewan, Canada.
authors: Glendon W
authors: GW
authors: Rhoades
authors: Department of Biomedical Imaging and Therapy Beamlines, Canadian Light Source, Saskatoon, Saskatchewan, Canada. alan.rosenberg@usask.ca.
authors: George S
authors: GS
authors: Belev
authors: Department of Anatomy and Cell Biology, Canadian Light Source, Saskatoon, Saskatchewan, Canada.
authors: L Dean
authors: LD
authors: Chapman
authors: Department of Medical Imaging, Canadian Light Source, Saskatoon, Saskatchewan, Canada.
authors: Sheldon P
authors: SP
authors: Wiebe
authors: Department of Anatomy and Cell Biology, Canadian Light Source, Saskatoon, Saskatchewan, Canada.
authors: David M
authors: DM
authors: Cooper
authors: Department of Medical Imaging, Canadian Light Source, Saskatoon, Saskatchewan, Canada.
authors: Adelaine Tf
authors: AT
authors: Wong
authors: Department of Pediatrics, University of Saskatchewan, Canadian Light Source, Saskatoon, Saskatchewan, Canada.
authors: Alan M
authors: AM
authors: Rosenberg
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001175:Arthrography / Q000295:instrumentation* / Q000379:methods*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000254:growth & development; D007596:Joints / Q000254:growth & development*; D008297:Male; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted; D013552:Swine; D017356:Synchrotrons; D014057:Tomography, X-Ray Computed