title: In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform.
abstract: A new strategy for efficient in vivo image-guided photodynamic therapy (PDT) has been demonstrated utilizing a ligand-exchange constructed upconversion-C60 nanophotosensitizer. This theranostic platform is superior to the currently reported nanophotosensitizers in (i) directly bonding photosensitizer C60 to the surface of upconversion nanoparticles (UCNPs) by a smart ligand-exchange strategy, which greatly shortened the energy transfer distance and enhanced the (1)O2 production, resulting in the improvement of the therapeutic effect; (ii) realizing in vivo NIR 808 nm image-guided PDT with both excitation (980 nm) and emission (808 nm) light falling in the biological window of tissues, which minimized auto-fluorescence, reduced light scatting and improved the imaging contrast and depth, and thus guaranteed noninvasive diagnostic accuracy. In vivo and ex vivo tests demonstrated its favorable bio-distribution, tumor-selectivity and high therapeutic efficacy. Owing to the effective ligand exchange strategy and the excellent intrinsic photophysical properties of C60, (1)O2 production yield was improved, suggesting that a low 980 nm irradiation dosage (351 J cm(-2)) and a short treatment time (15 min) were sufficient to perform NIR (980 nm) to NIR (808 nm) image-guided PDT. Our work enriches the understanding of UCNP-based PDT nanophotosensitizers and highlights their potential use in future NIR image-guided noninvasive deep cancer therapy.
authors: State Key Laboratory of Luminescence and Applications. Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, 130033, Changchun, Jilin, China. xgkong14@ciomp.ac.cn.
authors: Xiaomin
authors: X
authors: Liu
authors: Ivo
authors: I
authors: Que
authors: Xianggui
authors: X
authors: Kong
authors: Youlin
authors: Y
authors: Zhang
authors: Langping
authors: L
authors: Tu
authors: Yulei
authors: Y
authors: Chang
authors: Tong Tong
authors: TT
authors: Wang
authors: Alan
authors: A
authors: Chan
authors: Clemens W G M
authors: CW
authors: Löwik
authors: Hong
authors: H
authors: Zhang
mesh_terms: D000818:Animals; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D017319:Photosensitizing Agents