title: Gender-specific association between night-work exposure and type-2 diabetes: results from longitudinal study of adult health, ELSA-Brasil.
abstract: OBJECTIVE
  Diabetes is a multifactorial disease of increasing prevalence. The literature suggests an impact of night work on metabolic components, though the relationship with diabetes is unclear. Our aim was to investigate gender-specific associations between night work and type-2 diabetes (DM2) or impaired glucose tolerance (IGT) using baseline data of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
  
  
  METHODS
  The cohort comprised 15 105 civil servants, aged 35-74 years. Baseline assessments (2008-2010) included clinical and laboratory measurements and interviews on sociodemographic, occupational, and health characteristics.
  
  
  RESULTS
  In the baseline sample (N=14 427), 19.6% were classified as having DM2 and 20.5% as having IGT. Mean age was 52.1 (SD 9.1) years. A total of 2041 participants worked at night for 1-20 years and 687 for >20 years. Among women exposed to night work for >20 years compared with no night work after adjustments for potential confounders, including obesity, the odds ratios (OR) derived from multinomial logistic regression for DM2 and IGT were 1.42 [95% confidence interval (95% CI) 1.39-1.45] and 0.96 (95% CI 0.94-0.99), respectively. Among men exposed to night work for >20 years compared with no night work, the OR for DM2 and IGT were 1.06 (95% CI 1.04-1.08) and 0.99 (95% CI 0.98-1.01), respectively.
  
  
  CONCLUSIONS
  The association between years of night work and diabetes is stronger among women than men. Longitudinal studies from ELSA-Brasil will be able to corroborate or refute these findings.
authors: National School of Public Health, Oswaldo Cruz Foundation - ENSP/FIOCRUZ, Brazil. Institutional address and email: Av. Brasil 4365, Fiocruz, Pavilhão Lauro Travassos. Rio de Janeiro, RJ, Brazil. CEP 21.045-900. alinecos@ioc.fiocruz.br.
authors: Aline
authors: A
authors: Silva-Costa
authors: Lúcia
authors: L
authors: Rotenberg
authors: Aline Araújo
authors: AA
authors: Nobre
authors: Maria Inês
authors: MI
authors: Schmidt
authors: Dora
authors: D
authors: Chor
authors: Rosane Härter
authors: RH
authors: Griep
mesh_terms: D000328:Adult; D001938:Brazil; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016272:Occupational Health; D010561:Personnel Staffing and Scheduling / Q000706:statistics & numerical data*; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D013997:Time Factors; D014940:Work Schedule Tolerance