title: Access to Imidazo[1,2-a]pyridines via Annulation of α-Keto Vinyl Azides and 2-Aminopyridines.
abstract: A novel strategy for the synthesis of imidazo[1,2-a]pyridines via efficient catalyst/metal-free annulations of α-keto vinyl azides and 2-aminopyridines is described. Several imidazo[1,2-a]pyridines were synthesized from readily available vinyl azides and 2-aminopyridines and obtained in highly pure form by simply evaporating the reaction solvent. This remarkably high yielding and atom economical protocol allows the formation of three new C-N bonds through cascade reactions and rearrangements.
authors: Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT) , Hyderabad-500007, India.
authors: Praveen Reddy
authors: PR
authors: Adiyala
authors: Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT) , Hyderabad-500007, India.
authors: Geeta Sai
authors: GS
authors: Mani
authors: Centre for X-ray Crystallography, CSIR-IICT, Hyderabad-500007, India.
authors: Jagadeesh Babu
authors: JB
authors: Nanubolu
authors: Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT) , Hyderabad-500007, India.
authors: Kunta Chandra
authors: KC
authors: Shekar
authors: Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT) , Hyderabad-500007, India.
authors: Ram Awatar
authors: RA
authors: Maurya