title: The effectiveness of dentifrices without and with sodium lauryl sulfate on plaque, gingivitis and gingival abrasion--a randomized clinical trial.
abstract: OBJECTIVE
  The aim of this study was to compare the efficacy of a dentifrice without sodium lauryl sulfate (SLS) to a dentifrice with SLS in young adults aged 18-34 years on gingivitis.
  
  
  METHODS
  One hundred twenty participants (non-dental students) with a moderate gingival inflammation (bleeding on probing at 40-70 % of test sites) were included in this randomized controlled double blind clinical trial. According to randomization, participants had to brush their teeth either with dentifrice without SLS or with SLS for 8 weeks. The primary outcome was bleeding on marginal probing (BOMP). The secondary outcomes were plaque scores and gingival abrasion scores (GA) as well as a visual analogue scale (VAS) score at exit survey. Baseline and end differences were analysed by univariate analysis of covariance (ANCOVA) test, between group differences by independent t test and within groups by paired sample t test.
  
  
  RESULTS
  BOMP improved within groups from on average 0.80 at baseline to 0.60 in the group without SLS and to 0.56 in the group with SLS. No statistical difference for BOMP, plaque and gingival abrasion was found between both groups. VAS scores for taste, freshness and foaming effect were significantly in favour of the SLS-containing dentifrice.
  
  
  CONCLUSIONS
  The test dentifrice without SLS was as effective as a regular SLS dentifrice on gingival bleeding scores and plaque scores. There was no significant difference in the incidence of gingival abrasion.
  
  
  CONCLUSIONS
  In patients diagnosed with gingivitis, a dentifrice without SLS seems to be equally effective compared to a dentifrice with SLS and did not demonstrate any significant difference in gingival abrasion. In patient with recurrent aphthous ulcers, the absence of SLS may even be beneficial. However, participants indicate that they appreciate the foaming effect of a dentifrice with SLS more.
authors: Clinic for Conservative Dentistry and Periodontology; School for Dental Medicine, Christian-Albrechts-University Kiel, Kiel, Germany.|Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
authors: S
authors: S
authors: Sälzer
authors: Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
authors: N A M
authors: NA
authors: Rosema
authors: Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
authors: E C J
authors: EC
authors: Martin
authors: Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
authors: D E
authors: DE
authors: Slot
authors: Sara Lee Corporation, Amersfoort, Netherlands.
authors: C J
authors: CJ
authors: Timmer
authors: Clinic for Conservative Dentistry and Periodontology; School for Dental Medicine, Christian-Albrechts-University Kiel, Kiel, Germany.
authors: C E
authors: CE
authors: Dörfer
authors: Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands. ga.vd.weijden@acta.nl.
authors: G A
authors: GA
authors: van der Weijden
mesh_terms: D000293:Adolescent; D000328:Adult; D045424:Complex Mixtures / Q000737:chemistry / Q000627:therapeutic use*; D003773:Dental Plaque / Q000188:drug therapy*; D003774:Dental Plaque Index; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005881:Gingiva / Q000187:drug effects / Q000293:injuries; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010512:Periodontal Index; D012967:Sodium Dodecyl Sulfate; D011795:Surveys and Questionnaires; D014099:Toothbrushing
chemical_list: D045424:Complex Mixtures; D003802:Dentifrices; C000621567:Zendium classic; D012967:Sodium Dodecyl Sulfate
keywords: Dentifrice; Gingival abrasion; Gingivitis; Manual toothbrush; Plaque; SLS; Sodium lauryl sulfate; Toothpaste