title: The risk of diabetes development in long-term observation of patients with acute hyperglycaemia during myocardial infarction.
abstract: BACKGROUND
  Acute hyperglycemia in patients with myocardial infarction is an unfavorable predictive factor. However, there are limited data regarding the relationship between acute hyperglycemia and the incidence of new onsets diabetes in long-term observation.
  
  
  OBJECTIVE
  We studied the relationship between admission glycemia in patients with myocardial infarction and the future development of diabetes.
  
  
  METHODS
  In 190 patients admitted during 2004-2007 years with myocardial infarction diabetes was excluded on the basis of oral glucose tolerance test (OGTT) performed at the end of hospitalization. Patients were divided into three groups according to admission glucose level: G1 <7.8 mmol/l (<140 mg/dl); G2: 7.8-11.0 mmol/l (140-199 mg/dl); G3 ≥11.1 mmol/l (≥200 mg/dl).
  
  
  RESULTS
  The groups consisted of 80 (42.1%), 94 (49.5%) and 16 (8.4%) patients, respectively for G1, G2 and G3. The mean age was 61.3±11.3 years. ST-segment elevation myocardial infarction (STEMI) was diagnosed in 158 patients (83.2%) and non-ST-segment elevation myocardial infarction (NSTEMI) in 32 patients (16.8%). A total of 15 cases (7.9% of the study group) of newly diagnosed diabetes mellitus were registered during a mean follow-up of 48.2±13.9 months. Higher incidence of new diabetes diagnosis was noticed in patients with higher glucose level on admission (5.0% vs. 7.4% vs. 25.0%, p=0.0249). Regression analysis showed two independent risk factors of diabetes development in observational period: admission glucose level considered as continuous variable with OR 1.2 (95% CI 1.0-1.4, p=0.03) and occurrence of IGT with OR 3.6 (95% CI 1.0-12.0, p=0.04).
  
  
  CONCLUSIONS
  Patients with acute hyperglycemia during myocardial infarction are more likely to have diabetes in future. This group of patients requires a close monitoring of glucose metabolism after myocardial infarction.
authors: Michał
authors: M
authors: Terlecki
authors: Leszek
authors: L
authors: Bryniarski
authors: Agnieszka
authors: A
authors: Bednarek
authors: 1st Department of Cardiology, Interventional Electrocardiology, and Hypertension, Jagiellonian University, Medical College, Krakow, Poland. marylak@gmail.com.
authors: Maryla
authors: M
authors: Kocowska
authors: Kalina
authors: K
authors: Kawecka-Jaszcz
authors: Danuta
authors: D
authors: Czarnecka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D011379:Prognosis; D012307:Risk Factors