title: [Formation mechanism of circulating tumor cells and progress of its application in I-III stage colorectal carcinoma].
abstract: It has been a problem in clinical practice that high recurrence and poor survival of patients with colorectal cancer undergoing surgery. As an easy-accessible, repetitive, non-invasive "liquid biopsy" technology, circulating tumor cells(CTC) can assist us in many fields, for instance, real-time monitoring tumor status and providing information about recurrence and prognosis of colorectal cancer. In this review, generation mechanism and relevant major regulation molecules of CTC will be elucidated, and principles, superiorities and inferiorities among different detection technologies were compared. Besides, clinical application and prognostic value of CTC in stage I-III colorectal caner were discussed, and the dilemma of low detection rate of CTC will be tried to solve as well.
authors: Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. yuanying1999@zju.edu.cn.
authors: Qing
authors: Q
authors: Huang
authors: Shu
authors: S
authors: Zheng
authors: Jiao
authors: J
authors: Yang
authors: Ying
authors: Y
authors: Yuan
mesh_terms: D015179:Colorectal Neoplasms; D006801:Humans; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating; D011379:Prognosis