title: Association Between Interleukin-2 -330 T/G Polymorphism and Acute Renal Graft Rejection: A Meta-analysis.
abstract: BACKGROUND
  Interleukin-2 (IL-2) -330 T/G promoter polymorphism is involved in the acute rejection (AR) risk of kidney transplantation. However, results from published studies on the association between recipient IL-2-330 T/G polymorphism and AR risk are conflicting and inconclusive.
  
  
  METHODS
  We searched Medline, Embase, Web of Science, and Cochrane Central Register from their inceptions through January 2015 for relevant studies. Data concerning publication information, population characteristics, and transplant information were extracted. Odds ratios (ORs) were calculated for the association between IL-2-330 T/G polymorphism and AR risk.
  
  
  RESULTS
  This meta-analysis included 8 case-control studies with 1,405 cases of renal transplant recipients. The pooled estimate showed that IL-2-330 T/G polymorphism was not associated with AR risk: TT vs TG+GG: OR(fixed,) 0.93; 95% confidence interval [CI], 0.72-1.21; P = .60; GG vs TG+TT: OR(fixed), 1.15; 95% CI, 0.76-1.72; P = .51; TG vs TT+GG: OR(fixed), 1.01; 95% CI, 0.78-1.31; P = .91; T vs G: OR(fixed), 0.93; 95% CI, 0.77-1.13; P = .48. None of subgroup analyses yielded significant results in the association between IL-2-330 T/G polymorphism and AR risk. Meta-regression confirmed that there was no significant correlation between the preselected trial characteristics and our study results.
  
  
  CONCLUSIONS
  This meta-analysis suggests that IL-2-330 T/G polymorphism may not be associated with AR risk in renal transplant recipients.
authors: Chongqing Center for Clinical Laboratory, Yuzhong, Chongqing, China; Department of Clinical Laboratory Medicine, Third People's Hospital of Chongqing, Yuzhong, Chongqing, China.
authors: Q
authors: Q
authors: Hu
authors: Chongqing Center for Clinical Laboratory, Yuzhong, Chongqing, China; Department of Clinical Laboratory Medicine, Third People's Hospital of Chongqing, Yuzhong, Chongqing, China.
authors: H
authors: H
authors: Tian
authors: Chongqing Center for Clinical Laboratory, Yuzhong, Chongqing, China; Department of Clinical Laboratory Medicine, Third People's Hospital of Chongqing, Yuzhong, Chongqing, China.
authors: Q
authors: Q
authors: Wu
authors: Chongqing Center for Clinical Laboratory, Yuzhong, Chongqing, China; Department of Clinical Laboratory Medicine, Third People's Hospital of Chongqing, Yuzhong, Chongqing, China.
authors: J
authors: J
authors: Li
authors: Department of Cardiology, Banan People's Hospital of Chongqing, Banan, Chongqing, China.
authors: X
authors: X
authors: Cheng
authors: Chongqing Center for Clinical Laboratory, Yuzhong, Chongqing, China; Department of Clinical Laboratory Medicine, Third People's Hospital of Chongqing, Yuzhong, Chongqing, China. Electronic address: liaopu222@163.com.
authors: P
authors: P
authors: Liao
mesh_terms: D000208:Acute Disease; D006084:Graft Rejection / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics* / Q000378:metabolism; D007674:Kidney Diseases / Q000628:therapy; D016030:Kidney Transplantation; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D007376:Interleukin-2