title: Comparison of Rebound Tonometry, Perkins Applanation Tonometry and Ocular Response Analyser in Mucopolysaccharidosis Patients.
abstract: OBJECTIVE
  To investigate the feasibility and to compare three devices measuring intraocular pressure (IOP) in mucopolysaccharidosis patients (MPS): iCare rebound tonometer (RT), Perkins applanation tonometer (PAT) and ocular response analyzer (ORA).
  
  
  METHODS
  MPS patients who underwent at least two examinations out of: RT, PAT and ORA at the same visit were identified and retrospectively analyzed in this study.
  
  
  RESULTS
  17 patients fulfilled the inclusion criterion. In all 17 patients IOP measurements were performed with RT (34 eyes) and ORA (33 eyes), while PAT measurement was possible in only 12 (24 eyes) patients. The RT, corneal-compensated intraocular pressure (IOPcc) and Goldmann-correlated intraocular pressure (IOPg) differed relevantly from IOP assessed with PAT. Corneal clouding in MPS patients correlated positively with PAT, RT and IOPg (r = 0.3, 0.5, and 0.5 respectively), but not with IOPcc (r = 0.07). The MPS-related corneal clouding correlated positively with biomechanical corneal parameters assessed with ORA: corneal hysteresis (r = 0.77) and corneal resistance factor (r = 0.77) either.
  
  
  CONCLUSIONS
  RT and ORA measurements were tolerated better than applanation tonometry in MPS patients. IOP measurements assessed with RT and ORA differed relevantly from PAT. Corneal-compensated IOP assessed with ORA seems to be less affected by the MPS-related corneal clouding than applanation or rebound tonometry. RT and ORA measurements should be preferred for IOP assessment in patients with MPS.
authors: Department of Ophthalmology, University Medical Center of the Johannes Gutenberg- University Mainz, Mainz, Germany.
authors: Joanna
authors: J
authors: Wasielica-Poslednik
authors: Department of Ophthalmology, University Medical Center of the Johannes Gutenberg- University Mainz, Mainz, Germany.
authors: Christina
authors: C
authors: Butsch
authors: Department of Pediatrics, Dr. Horst Schmidt Clinic GmbH, Wiesbaden, Germany.
authors: Christina
authors: C
authors: Lampe
authors: Department of Ophthalmology, University Medical Center of the Johannes Gutenberg- University Mainz, Mainz, Germany.
authors: Heike
authors: H
authors: Elflein
authors: Department of Ophthalmology, University Medical Center of the Johannes Gutenberg- University Mainz, Mainz, Germany.
authors: Julia
authors: J
authors: Lamparter
authors: Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors: Veronika
authors: V
authors: Weyer
authors: Department of Ophthalmology, University Medical Center of the Johannes Gutenberg- University Mainz, Mainz, Germany.
authors: Susanne
authors: S
authors: Pitz
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003315:Cornea / Q000473:pathology / Q000503:physiopathology*; D005240:Feasibility Studies; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009083:Mucopolysaccharidoses / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D014065:Tonometry, Ocular / Q000295:instrumentation*; D055815:Young Adult