title: [A Case of StageIV Gastric Cancer with Development of Trousseau's Syndrome during Neoadjuvant Chemotherapy].
abstract: In October 2012, a man in his 60s was hospitalized for the examination of ascites, and was diagnosed with gastric cancer and carcinomatous peritonitis. S-1+cisplatin (CDDP) therapy was administered as neoadjuvant chemotherapy; however, during therapy, he developed cerebral infarction. We suspected that the cerebral infarction was caused by a coagulation disorder owing to Trousseau's syndrome. After completing 5 courses of chemotherapy, total gastrectomy was performed. Thereafter, the treatment was changed to S-1+docetaxel(DTX), followed by nab-paclitaxel (PTX). Although cerebral infarction did not relapse after the administration of an anticoagulant agent, the patient died of gastric cancer 1 year and 5 months after the operation. Trousseau's syndrome is a coagulation disorder in cancer patients. Cerebral infarctions caused by Trousseau's syndrome have a high tendency to relapse, and the prognosis is poor. This syndrome should be kept in mind when treating cancer patients.
authors: Dept. of Surgery, Nagato General Hospital.
authors: Yotaro
authors: Y
authors: Amasaki
authors: Takayuki
authors: T
authors: Kuga
authors: Yuka
authors: Y
authors: Kunisue
authors: Ken
authors: K
authors: Hirata
authors: Yasuhiro
authors: Y
authors: Fujii
authors: Yuuji
authors: Y
authors: Nagatomi
authors: Kimikazu
authors: K
authors: Hamano
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000188:drug therapy / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000925:Anticoagulants