title: Choroidal Thickness in Turkish Children with Anisometric Amblyopia.
abstract: OBJECTIVE
  To assess macular choroidal thickness (CT) and axial length measurements in children with anisometropic amblyopia and to compare the measurements with that of fellow non-amblyopic eyes and age-sex matched controls.
  
  
  METHODS
  Forty patients with anisometropic amblyopia and 40 age-/sex-matched controls were evaluated in this study. Eyes were classified into three groups as follows: amblyopic eyes (n = 40), fellow non-amblyopic eyes, and healthy eyes (n = 40). All subjects underwent complete ophthalmic examination and macular choroidal thickness measurements by enhanced depth imaging method of the Spectralis optical coherence tomography system. CT was measured at the fovea and at 1000-μm intervals from the foveal center in both temporal and nasal directions. The statistical assessment was performed with the assistance of one-way analysis of variance (ANOVA) and Pearson's correlation test.
  
  
  RESULTS
  The mean subfoveal CT was 389.35, 349.07, and 315.8 μm in the amblyopic, fellow non-amblyopic and healthy eyes, respectively. Choroid was thickest in subfoveal and thinnest in nasal regions among all groups. Both amblyopic and fellow non-amblopic eyes were more hyperopic than healthy eyes. While the subfoveal and nasal CT in amblyopic eyes and fellow eyes were significantly higher than healthy eyes, the temporal CT in amblyopic eyes was significantly higher than in healthy eyes. There was a significant positive correlation between the CT of the subfoveal, nasal, and temporal regions and the refractive state (r = 0.432 p = 0.001; r = 0.324 p = 0.001; r = 0.215 p = 0.01, respectively).
  
  
  CONCLUSIONS
  The macular choroidal thickness-not only in amblyopic eyes but also in non-amblyopic fellow eyes-was significantly thicker than in the healthy subjects. The thick choroid in amblyopic and non-amblyopic fellow eyes may indicate bilateral delay of emmetropization, which probably means amblyopia affecting the visual feedback of both eyes.
authors: a Sorgun State Hospital, Department of Ophthalmology , Yozgat , Turkey.
authors: Emine Esra
authors: EE
authors: Karaca
authors: b Gazi University, School of Medicine, Department of Ophthalmology , Ankara , Turkey.
authors: Mehmet Özgür
authors: MÖ
authors: Çubuk
authors: c Cankiri State Hospital, Department of Ophthalmology , Cankiri , Turkey.
authors: Hanife Tuba
authors: HT
authors: Akçam
authors: d Recep Tayyip Erdoğan University, School of Medicine, Department of Ophthalmology , Rize , Turkey.
authors: Feyzahan
authors: F
authors: Uzun
authors: b Gazi University, School of Medicine, Department of Ophthalmology , Ankara , Turkey.
authors: Erdem
authors: E
authors: Yüksel
mesh_terms: D000293:Adolescent; D000550:Amblyopia / Q000175:diagnosis* / Q000503:physiopathology; D015858:Anisometropia / Q000175:diagnosis* / Q000503:physiopathology; D058452:Axial Length, Eye; D002648:Child; D002675:Child, Preschool; D002829:Choroid / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
keywords: Amblyopia; axial length; choroidal thickness; emmetropization; thick choroid