title: Distribution and risk of the second discordant primary cancers combined after a specific first primary cancer in German and Swedish cancer registries.
abstract: We aimed at investigating the distribution and risk of all second discordant primary cancers (SDPCs) after a specific first primary cancer in Germany and Sweden to provide etiological understanding of SDPCs and insight into their incidence rates and recording practices. Among 1,537,004 survivors of first primary cancers in Germany and 588,103 in Sweden, overall 80,162 and 32,544 SDPCs were recorded, respectively. Standardized incidence ratios (SIRs) of all SDPCs were elevated at levels between 1.1 and 2.1 after 23 (out of overall 29) cancers in Germany and at levels between 1.1 and 1.6 after 24 cancers in Sweden, and among them, elevated SIRs were found after 19 cancers in both populations. Decreased SIRs at levels ranging from 0.5 to 0.9 were found for some cancers with poor prognosis in Germany only. We found elevated risk after 19 out of 29 cancers in both countries, suggesting common etiology of SDPCs after most of first cancers and registration similarity. Decreased risks after some fatal cancers were found only in Germany, which may be attributed to reporting practices or missed death data in Germany.
authors: Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. Electronic address: t.chen@dkfz.de.
authors: Tianhui
authors: T
authors: Chen
authors: Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.
authors: Mahdi
authors: M
authors: Fallah
authors: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
authors: Lina
authors: L
authors: Jansen
authors: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
authors: Felipe A
authors: FA
authors: Castro
authors: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
authors: Agne
authors: A
authors: Krilavicuite
authors: Institute of Cancer Epidemiology, University of Lübeck, Lübeck, Germany.
authors: Alexander
authors: A
authors: Katalinic
authors: Institute of Cancer Epidemiology, University of Lübeck, Lübeck, Germany.
authors: Nora
authors: N
authors: Eisemann
authors: Cancer Registry of Rhineland-Palatinate, Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg, Germany.
authors: Katharina
authors: K
authors: Emrich
authors: Saarland Cancer Registry, Saarbrüken, Germany.
authors: Bernd
authors: B
authors: Holleczek
authors: Bayern Cancer Registry, Munich, Germany.
authors: Karla
authors: K
authors: Geiss
authors: Cancer Registry of Bremen, Leibniz-Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
authors: Andrea
authors: A
authors: Eberle
authors: Center for Primary Health Care Research, Lund University, Malmö, Sweden; Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305-5705, USA.
authors: Jan
authors: J
authors: Sundquist
authors: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany.
authors: Hermann
authors: H
authors: Brenner
authors: Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany; Center for Primary Health Care Research, Lund University, Malmö, Sweden.
authors: Kari
authors: K
authors: Hemminki
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012042:Registries; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
keywords: Age at diagnosis; Cancer registry; Discordant cancer; Second primary cancers; Standardized incidence ratios