title: Association between helicobacter pylori infection and carcinoma of the larynx or pharynx.
abstract: Infection with Helicobacter pylori (H. pylori) plays a role in the development of gastric carcinoma. However, there is controversy as to whether H. pylori infection increases laryngeal or pharyngeal cancers.
  
  
  
  We managed a systematic review of researches related to H. pylori infection in laryngeal or pharyngeal carcinomas, distributed up to December 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were assessed by random effects models or according to heterogeneity I(2) .
  
  
  
  Eleven studies were involved in the meta-analysis. Overall, H. pylori infection was significantly higher in the study group compared with the normal control group (OR = 2.87; 95% CI = 1.71-4.84; I(2) = 67.1; p < .0001, random effects analysis). The ORs for laryngeal carcinoma were 3.28 (95% CI = 1.91-5.63; I(2) = 58; p < .0001, random effects model). The ORs for pharyngeal cancer were 1.35 (95% CI = 0.86-2.12; p = .188, random effects model).
  
  
  
  This study supported the proposition that infection with H. pylori was related to laryngeal carcinoma, specifically in the hospital-based control group and diagnosed by polymerase chain reaction (PCR) or enzyme-linked immunosorbent assay (ELISA). Nevertheless, no significant relationship was discovered between H. pylori infection and pharyngeal cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2291-E2296, 2016.
authors: Department of Otolaryngology, HNS, Eye, Ear, Nose, and Throat Hospital, Fudan University School of Medicine, Shanghai, China.
authors: Jian
authors: J
authors: Zhou
authors: Department of Otolaryngology, HNS, Eye, Ear, Nose, and Throat Hospital, Fudan University School of Medicine, Shanghai, China.
authors: Duo
authors: D
authors: Zhang
authors: Department of Otolaryngology, HNS, Eye, Ear, Nose, and Throat Hospital, Fudan University School of Medicine, Shanghai, China.
authors: Yue
authors: Y
authors: Yang
authors: Department of Otolaryngology, HNS, Eye, Ear, Nose, and Throat Hospital, Fudan University School of Medicine, Shanghai, China.
authors: Liang
authors: L
authors: Zhou
authors: Department of Otolaryngology, HNS, Eye, Ear, Nose, and Throat Hospital, Fudan University School of Medicine, Shanghai, China.
authors: Lei
authors: L
authors: Tao
mesh_terms: D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications / Q000382:microbiology*; D007830:Larynx / Q000382:microbiology / Q000473:pathology; D010614:Pharynx / Q000382:microbiology / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications / Q000382:microbiology*
keywords: Helicobacter pylori; laryngeal cancer; pharyngeal cancer