title: [Up-to-date applicability of interferon-γ release assays for the diagnosis of tuberculosis].
abstract: Utility of the in-vitro immunodiagnostic methods, based on the detection of interferon-γ released by T-cells after specific Mycobacterium tuberculosis antigen stimulation (IGRA), has been an improvement in the accuracy of the latent tuberculosis infection diagnosis. IGRA have a well-known higher specificity than the tuberculin skin testing (TST). Moreover, they can obtain a larger number of positive results than the TST in immunocompromised patients. IGRA have shown a high correlation with M. tuberculosis exposure, but their positive and negative predictive value are similar than those obtained by TST. Nevertheless, given their high specificity, they allow reducing number of unnecessary preventive treatments. In addition, these in-vitro techniques are less affected than TST by the different immunosuppressing status. In this review is discussed up-to-date applicability of IGRA in different patient groups: contact studies, pediatric population, immunosuppressed patients, health care workers and active tuberculosis patients. Furthermore, it has been included possible future directions for latent tuberculosis infection and active tuberculosis diagnosis.
authors: Servicio de Microbiología, Institut d'Investigació Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias, Badalona, Barcelona, España. Electronic address: jadomb@gmail.com.
authors: José
authors: J
authors: Domínguez
authors: Departamento de Microbiología Molecular, Hospital Universitari Sant Joan de Déu, Hospital de Barcelona, Barcelona, España.
authors: Irene
authors: I
authors: Latorre
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015897:Comorbidity; D016358:Contact Tracing; D003362:Cost-Benefit Analysis; D005544:Forecasting; D015658:HIV Infections / Q000453:epidemiology; D006282:Health Personnel; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000453:epidemiology; D059425:Interferon-gamma Release Tests / Q000191:economics; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology; D009784:Occupational Diseases / Q000175:diagnosis; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology
keywords: Diagnóstico in vitro; IGRA; In vitro diagnosis; Infección tuberculosa; Latent tuberculosis infection; Quantiferon; Quantiferón; T-SPOT.TB