title: Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.
abstract: BACKGROUND
  We previously reported an association between 5HTTLPR genotype and outcome following cognitive-behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome.
  
  
  OBJECTIVE
  To replicate the association between 5HTTLPR and CBT outcome in child anxiety from the Genes for Treatment study (GxT Cohort 2, n = 829).
  
  
  METHODS
  Logistic and linear mixed effects models were used to examine the relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both cohorts were performed.
  
  
  RESULTS
  There was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2. Mega-analyses identified a significant association between 5HTTLPR and remission from all anxiety disorders at follow-up (odds ratio 0.45, P = 0.014), but not primary anxiety disorder outcomes.
  
  
  CONCLUSIONS
  The association between 5HTTLPR genotype and CBT outcome did not replicate. Short-allele homozygotes showed more positive treatment outcomes, but with small, non-significant effects. Future studies would benefit from utilising whole genome approaches and large, homogenous samples.
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Kathryn J
authors: KJ
authors: Lester
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Susanna
authors: S
authors: Roberts
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Robert
authors: R
authors: Keers
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Jonathan R I
authors: JR
authors: Coleman
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Gerome
authors: G
authors: Breen
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Chloe C Y
authors: CC
authors: Wong
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Xiaohui
authors: X
authors: Xu
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Kristian
authors: K
authors: Arendt
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Judith
authors: J
authors: Blatter-Meunier
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Susan
authors: S
authors: Bögels
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Peter
authors: P
authors: Cooper
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Cathy
authors: C
authors: Creswell
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Einar R
authors: ER
authors: Heiervang
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Chantal
authors: C
authors: Herren
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Sanne M
authors: SM
authors: Hogendoorn
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Jennifer L
authors: JL
authors: Hudson
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Karen
authors: K
authors: Krause
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Heidi J
authors: HJ
authors: Lyneham
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Anna
authors: A
authors: McKinnon
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Talia
authors: T
authors: Morris
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Maaike H
authors: MH
authors: Nauta
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Ronald M
authors: RM
authors: Rapee
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Yasmin
authors: Y
authors: Rey
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Silvia
authors: S
authors: Schneider
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Sophie C
authors: SC
authors: Schneider
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Wendy K
authors: WK
authors: Silverman
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Patrick
authors: P
authors: Smith
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Mikael
authors: M
authors: Thastum
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Kerstin
authors: K
authors: Thirlwall
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Polly
authors: P
authors: Waite
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Gro Janne
authors: GJ
authors: Wergeland
authors: Kathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
authors: Thalia C
authors: TC
authors: Eley
mesh_terms: D000293:Adolescent; D000483:Alleles; D001008:Anxiety Disorders / Q000235:genetics* / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D015928:Cognitive Behavioral Therapy; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012074:Remission Induction; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins