title: Glycoprotein Ia C807T: Polymorphisms and Their Association with Platelet Function in Patients with the Acute Coronary Syndrome.
abstract: OBJECTIVE
  In the current study, we explored the relationship between glycoprotein Ia (GPIa) C807T polymorphisms and platelet function, and the sensitivity to dual antiplatelet treatment after percutaneous coronary intervention.
  
  
  METHODS
  We conducted a case-control study in 220 patients diagnosed with acute coronary syndrome (ACS) and 220 healthy controls. The platelet GPIa C807T genotypes of patients and controls were determined, and platelet aggregation and plasma concentrations of α-granule membrane protein (GMP-140) were assessed following stimulation with arachidonic acid and adenosine diphosphate.
  
  
  RESULTS
  The frequency of the GPIa T allele was higher in the ACS group than in controls. In the ACS group, platelet aggregation was significantly higher in individuals with the T allele than in those with the C allele. Dual antiplatelet treatment reduced platelet aggregation in all three genotypes, and patients carrying the CC genotype were more sensitive to antiplatelet treatment than those with the T allele, particularly the ones with the TT genotype. There were no differences in plasma GMP-140 levels.
  
  
  CONCLUSIONS
  The GPIa C807T polymorphism might be a risk factor for the development and relapse of ACS. The GP Ia T allele may help to identify a group of patients who need more aggressive antithrombotic treatment.
authors: Department of Cardiovascular Medicine, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, China.
authors: Qiang
authors: Q
authors: Zhang
authors: Yiqi
authors: Y
authors: Jin
authors: Dongmin
authors: D
authors: Shi
authors: Junrong
authors: J
authors: Gong
authors: Jing
authors: J
authors: Liu
authors: Yongyi
authors: Y
authors: Lu
authors: Min
authors: M
authors: Tong
authors: Jiankang
authors: J
authors: Wang
authors: Qi
authors: Q
authors: Song
authors: Jiamin
authors: J
authors: Dong
authors: Wenting
authors: W
authors: Chen
authors: Ke
authors: K
authors: Lv
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy / Q000235:genetics*; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010979:Platelet Function Tests; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D039421:Integrin alpha2; D019007:P-Selectin; D010975:Platelet Aggregation Inhibitors