title: Macrophage Expression of Inflammatory Genes in Response to EMCV Infection.
abstract: The expression and production of type 1 interferon is the classic cellular response to virus infection. In addition to this antiviral response, virus infection also stimulates the production of proinflammatory mediators. In this review, the pathways controlling the induction of inflammatory genes and the roles that these inflammatory mediators contribute to host defense against viral pathogens will be discussed. Specific focus will be on the role of the chemokine receptor CCR5, as a signaling receptor controlling the activation of pathways leading to virus-induced inflammatory gene expression.
authors: Department of Biochemistry, Medical College of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI 53226, USA. zshaheen@mcw.edu.
authors: Zachary R
authors: ZR
authors: Shaheen
authors: Department of Biochemistry, Medical College of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI 53226, USA. jcorbett@mcw.edu.
authors: John A
authors: JA
authors: Corbett
mesh_terms: D000818:Animals; D004686:Encephalomyocarditis virus / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000235:genetics; D008264:Macrophages / Q000166:cytology / Q000276:immunology / Q000378:metabolism* / Q000821:virology*; D012330:RNA, Double-Stranded / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
chemical_list: D012330:RNA, Double-Stranded
keywords: inflammation, cytokine, virus, macrophage, diabetes, Ccr5