title: Effector T cell differentiation: are master regulators of effector T cells still the masters?
abstract: Effector CD4 T cell lineages have been implicated as potent inducers of autoimmune diseases. Tbet, Gata3 and Rorgt are master transcriptional regulators of Th1, Th2 and Th17 lineages respectively and promote the distinct expression of signature cytokines. Significant progress has been made in understanding the transcriptional network that drives CD4 T cell differentiation, revealing novel points of regulation mediated by transcription factors, cell surface receptors, cytokines and chemokines. Epigenetic modifications and metabolic mediators define the transcriptional landscape in which master transcription factors operate and collaborate with a network of transcriptional modifiers to guide lineage specification, plasticity and function.
authors: Evergrande Center for Immunological Diseases, Harvard Medical School, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
authors: Chao
authors: C
authors: Wang
authors: Evergrande Center for Immunological Diseases, Harvard Medical School, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
authors: Mary
authors: M
authors: Collins
authors: Evergrande Center for Immunological Diseases, Harvard Medical School, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: vkuchroo@rics.bwh.harvard.edu.
authors: Vijay K
authors: VK
authors: Kuchroo
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D002454:Cell Differentiation; D019070:Cell Lineage; D060833:Cellular Microenvironment; D044127:Epigenesis, Genetic; D006801:Humans; D007167:Immunotherapy; D058990:Molecular Targeted Therapy; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*