title: Ligand-Enabled Meta-C-H Alkylation and Arylation Using a Modified Norbornene.
abstract: 2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.
authors: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Peng-Xiang
authors: PX
authors: Shen
authors: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Xiao-Chen
authors: XC
authors: Wang
authors: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Peng
authors: P
authors: Wang
authors: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Ru-Yi
authors: RY
authors: Zhu
authors: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Jin-Quan
authors: JQ
authors: Yu
mesh_terms: D000478:Alkylation; D006844:Hydrocarbons, Cyclic / Q000737:chemistry*; D008024:Ligands; D009636:Norbornanes / Q000737:chemistry*
chemical_list: D006844:Hydrocarbons, Cyclic; D008024:Ligands; D009636:Norbornanes