title: Acalculous pyelonephritis and cholecystitis occurring simultaneously in a diabetic patient on sitagliptin therapy.
abstract: Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of anti-diabetic drugs. They control both fasting and postprandial hyperglycemia by inhibiting degradation of incretin hormones, such as, glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Sitagliptin is the first DPP-4 inhibitor to be marketed in India. In addition to its glucose lowering effect, it also suppresses immunity resulting in various infections in a diabetes patient. Here, we describe the simultaneous development of two infections (acalculous pyelonephritis and cholecystitis) in a postmenopausal female patient, well-controlled on sitagliptin-based anti-diabetic therapy.
authors: Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: Jayaprakash
authors: J
authors: Sahoo
authors: Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: Sadishkumar
authors: S
authors: Kamalanathan
authors: Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: Muthupillai
authors: M
authors: Vivekanandan
authors: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: Rathinam Palamalai
authors: RP
authors: Swaminathan
keywords: Dipeptidyl peptidase-4; infection; oral hypoglycemic agents