title: Association of single nucleotide polymorphism rs7579169 with hypertension disorders during pregnancy and perinatal outcome.
abstract: BACKGROUND
  Hypertension during pregnancy is a heterogeneous group of disorders with elevated blood pressure with or without proteinuria. The multiple researches are held on the subject of a genetic conditioning of preeclampsia and pregnancy induced hypertension.
  
  
  OBJECTIVE
  The study was designed to evaluate the impact of the single nucleotide polymorphism (SNP) rs7579169 on hypertension disorders in pregnancy, especially on PE and PIH as well as on the perinatal outcome.
  
  
  METHODS
  It is a case-control study. The study included 104 women with uncomplicated pregnancies in the control group and 75 pregnant women with hypertension disorders in the study group, hospitalized in the Perinatology and Obstetrics Department of the University Hospital in Cracow. Genomic DNA was extracted from peripheral blood leukocytes and SNP rs7579169 was genotyped from all patients. We analyzed the genotypes distribution and allele frequencies of polymorphism rs7579169 and its association with perinatal outcome in all groups. A p-value<0.05 was considered as significant.
  
  
  RESULTS
  Clinical evaluation included standard anthropometric measures like weight and height for the calculation of the body mass index in the beginning and in the end of the pregnancy, blood pressure, time and a method of delivery, birth weight, Apgar score. The heterozygote CT was associated with a 4.5-fold increased risk of preeclampsia in pregnant patients. The presence of TT genotype significantly increased the risk of intrauterine growth restriction (<10 percentile).
  
  
  CONCLUSIONS
  The study show probable impact of SNP rs7579169 on pregnancy, but further studies on larger groups are needed.
authors: Jagiellonian University Medical College, Department of Obstetrics and Perinatology, Kraków, Poland.
authors: Katarzyna
authors: K
authors: Kuśmierska-Urban
authors: Jagiellonian University Medical College, Department of Obstetrics and Perinatology, Kraków, Poland.
authors: Krzysztof
authors: K
authors: Rytlewski
authors: Jagiellonian University Medical College, Department of Obstetrics and Perinatology, Kraków, Poland.
authors: Hubert
authors: H
authors: Huras
authors: Jagiellonian University Medical College, Department for Genetic Research and Nutrigenomics, Kraków, Poland.
authors: Iwona
authors: I
authors: Wybrańska
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D055815:Young Adult