title: Association of PDCD1 polymorphism to Systemic Lupus Erythematosus and Rheumatoid Arthritis susceptibility.
abstract: OBJECTIVE
  This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A - rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population.
  
  
  METHODS
  Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy-Weinberg Equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p≤0.05.
  
  
  RESULTS
  The PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data.
  
  
  CONCLUSIONS
  There was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population.
authors: Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors: Luisa Matos do
authors: LM
authors: Canto
authors: Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors: Ticiana Della Justina
authors: TD
authors: Farias
authors: Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors: Mayara Delagnelo
authors: MD
authors: Medeiros
authors: Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors: Cíntia Callegari
authors: CC
authors: Coêlho
authors: Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors: Aline Fernanda Rodrigues
authors: AF
authors: Sereia
authors: Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors: Lia Kubelka Fernandes de Carlos
authors: LK
authors: Back
authors: Serviço de Reumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade do Estado de São Paulo, São Paulo, SP, Brasil.
authors: Filipe Martins de
authors: FM
authors: Mello
authors: Divisão de Reumatologia, Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors: Adriana Fontes
authors: AF
authors: Zimmermann
authors: Divisão de Reumatologia, Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
authors: Ivânio Alves
authors: IA
authors: Pereira
authors: Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil. Electronic address: iliadarainha@gmail.com.
authors: Ilíada Rainha de
authors: IR
authors: Souza
keywords: Artrite reumatoide; Autoimmunity; Autoimunidade; Gene PDCD1; Lúpus eritematoso sistêmico; PD1.3 polymorphism; PDCD1 gene; Polimorfismo PD1.3; Rheumatoid arthritis; Systemic lupus erythematosus