title: Neonatal exposure to amphetamine alters social affiliation and central dopamine activity in adult male prairie voles.
abstract: The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating. Recent data have shown that amphetamine (AMPH) is rewarding to prairie voles as it induces conditioned place preferences. Further, repeated treatment with AMPH impairs social bonding in adult prairie voles through a central dopamine (DA)-dependent mechanism. The present study examined the effects of neonatal exposure to AMPH on behavior and central DA activity in adult male prairie voles. Our data show that neonatal exposure to AMPH makes voles less social in an affiliation test during adulthood, but does not affect animals' locomotor activity and anxiety-like behavior. Neonatal exposure to AMPH also increases the levels of tyrosine hydroxylase (TH) and DA transporter (DAT) mRNA expression in the ventral tegmental area (VTA) in the brain, indicating an increase in central DA activity. As DA has been implicated in AMPH effects on behavioral and cognitive functions, altered DA activity in the vole brain may contribute to the observed changes in social behavior.
authors: Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.
authors: D F
authors: DF
authors: Fukushiro
authors: Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.
authors: A
authors: A
authors: Olivera
authors: Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.
authors: Y
authors: Y
authors: Liu
authors: Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA. Electronic address: zwang@neuro.fsu.edu.
authors: Z
authors: Z
authors: Wang
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety / Q000473:pathology; D003411:Arvicolinae; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004195:Disease Models, Animal; D004298:Dopamine / Q000235:genetics / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D008124:Locomotion / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism; D012919:Social Behavior; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics / Q000378:metabolism
chemical_list: D000697:Central Nervous System Stimulants; D050483:Dopamine Plasma Membrane Transport Proteins; D012333:RNA, Messenger; D011954:Receptors, Dopamine; D000661:Amphetamine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine
keywords: affiliation; amphetamine; dopamine; elevated plus maze; nucleus accumbens; open field