title: Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt.
abstract: Effect of abdominal aorto-venocaval shunt (AVS) on the automaticity of the pulmonary-vein myocardium was studied in the rat. Spontaneous electrical activity was observed in one third of the isolated pulmonary-vein preparations from the AVS rats, but scarcely in those from sham-operated rats; the activity was induced by tertiapin and suppressed by carbachol or chelation of intracellular Ca(2+). The evoked action potentials in AVS rats had less negative resting membrane potential and longer action potential duration than those in sham-operated rats. These results suggest that the automaticity of the rat pulmonary-vein myocardium is manifested under chronic volume overload.
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan. Electronic address: shogo.hamaguchi@phar.toho-u.ac.jp.
authors: Shogo
authors: S
authors: Hamaguchi
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan; Laboratory of Pharmacology, Faculty of Pharmaceutical Science, Tokyo University of Sciences, Noda, Chiba 278-8510, Japan.
authors: Yayoi
authors: Y
authors: Tsuneoka
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
authors: Ayumi
authors: A
authors: Tanaka
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
authors: Masahiko
authors: M
authors: Irie
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
authors: Masato
authors: M
authors: Tsuruta
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
authors: Takahiro
authors: T
authors: Nakayama
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
authors: Iyuki
authors: I
authors: Namekata
authors: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
authors: Mizuki
authors: M
authors: Nada
authors: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
authors: Megumi
authors: M
authors: Aimoto
authors: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
authors: Akira
authors: A
authors: Takahara
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
authors: Hikaru
authors: H
authors: Tanaka
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000714:Anastomosis, Surgical; D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery*; D001514:Bee Venoms / Q000494:pharmacology; D065096:Calcium Chelating Agents / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology*; D004195:Disease Models, Animal; D005071:Evoked Potentials / Q000187:drug effects*; D006321:Heart / Q000502:physiology; D006325:Heart Atria; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D009206:Myocardium; D011667:Pulmonary Veins / Q000503:physiopathology*; D017208:Rats, Wistar; D014682:Vena Cava, Inferior / Q000601:surgery*
chemical_list: D001514:Bee Venoms; D065096:Calcium Chelating Agents; C029738:tertiapin; D002217:Carbachol
keywords: Aorto-venocaval shunt; Pulmonary vein; Spontaneous activity