title: Exploring Genetic Susceptibility to Fibromyalgia.
abstract: Fibromyalgia (FM) affects 1% to 5% of the population, and approximately 90% of the affected individuals are women. FM patients experience impaired quality of life and the disorder places a considerable economic burden on the medical care system. With the recognition of FM as a major health problem, many recent studies have evaluated the pathophysiology of FM. Although the etiology of FM remains unknown, it is thought to involve some combination of genetic susceptibility and environmental exposure that triggers further alterations in gene expression. Because FM shows marked familial aggregation, most previous research has focused on genetic predisposition to FM and has revealed associations between genetic factors and the development of FM, including specific gene polymorphisms involved in the serotonergic, dopaminergic, and catecholaminergic pathways. The aim of this review was to discuss the current evidence regarding genetic factors that may play a role in the development and symptom severity of FM.
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Dong-Jin
authors: DJ
authors: Park
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Ji-Hyoun
authors: JH
authors: Kang
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Yi-Rang
authors: YR
authors: Yim
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Ji-Eun
authors: JE
authors: Kim
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Jeong-Won
authors: JW
authors: Lee
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Kyung-Eun
authors: KE
authors: Lee
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Lihui
authors: L
authors: Wen
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Tae-Jong
authors: TJ
authors: Kim
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Yong-Wook
authors: YW
authors: Park
authors: Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors: Shin-Seok
authors: SS
authors: Lee
keywords: Fibromyalgia; Genes; Polymorphism, Genetic