title: Evaluation of Pre-Treatment and Post-Treatment S100B, Oxidant and Antioxidant Capacity in Children with Diabetic Ketoacidosis.
abstract: OBJECTIVE
  The study aimed to evaluate the pre-treatment and post-treatment oxidant capacity, antioxidant capacity and S100B protein levels in cases of diabetic ketoacidosis (DKA).
  
  
  METHODS
  The study included 49 pediatric patients diagnosed with DKA and a control group comprising 49 healthy children. Blood samples were obtained after confirmation of the DKA diagnosis and also after treatment. S100B, total oxidant (TOL) and total antioxidant levels (TAL) were measured and the oxidative stress index (OSI) was calculated.
  
  
  RESULTS
  When the pre-treatment and post-treatment values of patients with DKA were compared with those of the healthy control group, the S100B level, TOL, TAL and OSI were found to be significantly higher in the diabetes group (p<0.001). Pre-treatment TOL and TAL were also significantly higher than post-treatment levels (p<0.001), while no statistically significant difference was found in the S100B levels or the OSI (p>0.05).
  
  
  CONCLUSIONS
  We believe that long-term exposure to high blood glucose concentrations leads to an increase in TOL in patients with DKA and that the neurotransmitter changes that develop in response to this exposure lead to an increase in S100B levels, which is an indicator of neuronal damage.
authors: Cemil
authors: C
authors: Kaya
authors: Ali
authors: A
authors: Ataş
authors: Nurten
authors: N
authors: Aksoy
authors: Esra Celen
authors: EC
authors: Kaya
authors: Harran University Faculty of Medicine, Department of Pediatric, Şanlıurfa, Turkey Phone: +90 414 318 30 00 E-mail: mabuhandan@gmail.com.
authors: Mahmut
authors: M
authors: Abuhandan
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D016883:Diabetic Ketoacidosis / Q000097:blood* / Q000628:therapy*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D005609:Free Radicals; D018377:Neurotransmitter Agents; D016877:Oxidants; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human