title: Laparoscopic management of liver metastases from uveal melanoma.
abstract: Although uveal melanoma is a rare disease, its metastasis to the liver is associated with a poor survival. The aim of this study is to analyze the survival after surgical treatment of uveal melanoma metastases to the liver.
  
  
  
  Within 15 years, 44 patients with uveal melanoma metastases to the liver were managed at a single center. Medical records were reviewed to identify patients who underwent surgical treatment of their liver disease. Clinical and oncologic results were compared to those patients who were managed otherwise. T test, Chi-square test, and Kaplan-Meier survival analyses were performed.
  
  
  
  There were 16 patients who underwent surgical treatment (laparoscopic liver resection, n = 2 and laparoscopic radiofrequency ablation, n = 14), compared to 28 patients who received systemic therapy. The groups were similar regarding demographics and size of primary tumor. The interval between diagnoses of primary tumor and liver metastases was longer for the surgical group (58 vs 22 months, respectively, p = 0.010). Although the dominant liver tumor size was similar, the average number of liver tumors was 4 in the surgical group and 10 in the systemic therapy group (p < 0.0001). The median survival after diagnosis of liver metastases was 35 months in the surgical group and 15 months in the systemic therapy group (p ≤ 0.0001). Five-year survival was zero in the systemic therapy group and 22 % in the surgical group.
  
  
  
  This study shows that surgical treatment of liver metastases in selected patients with uveal melanoma, who have limited liver tumor burden and a long interval to metastases development, may result in long-term survival.
authors: Departments of Endocrine and General Surgery, Cleveland Clinic, 9500 Euclid Avenue/F20, Cleveland, OH, 44195, USA.
authors: Muhammet
authors: M
authors: Akyuz
authors: Departments of Endocrine and General Surgery, Cleveland Clinic, 9500 Euclid Avenue/F20, Cleveland, OH, 44195, USA.
authors: Pınar
authors: P
authors: Yazici
authors: Departments of Endocrine and General Surgery, Cleveland Clinic, 9500 Euclid Avenue/F20, Cleveland, OH, 44195, USA.
authors: Cem
authors: C
authors: Dural
authors: Departments of Endocrine and General Surgery, Cleveland Clinic, 9500 Euclid Avenue/F20, Cleveland, OH, 44195, USA.
authors: Hakan
authors: H
authors: Yigitbas
authors: Departments of Endocrine and General Surgery, Cleveland Clinic, 9500 Euclid Avenue/F20, Cleveland, OH, 44195, USA.
authors: Alexis
authors: A
authors: Okoh
authors: Departments of Endocrine and General Surgery, Cleveland Clinic, 9500 Euclid Avenue/F20, Cleveland, OH, 44195, USA.
authors: Emre
authors: E
authors: Bucak
authors: Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USA.
authors: Michael
authors: M
authors: McNamara
authors: The Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
authors: Arun
authors: A
authors: Singh
authors: Departments of Endocrine and General Surgery, Cleveland Clinic, 9500 Euclid Avenue/F20, Cleveland, OH, 44195, USA. berbere@ccf.org.
authors: Eren
authors: E
authors: Berber
mesh_terms: D017115:Catheter Ablation; D005260:Female; D006498:Hepatectomy; D006801:Humans; D010535:Laparoscopy; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D008875:Middle Aged; D012189:Retrospective Studies; D014604:Uveal Neoplasms / Q000473:pathology*
keywords: Laparoscopic liver resection; Laparoscopic radiofrequency ablation; Liver metastases; Uveal melanoma