title: Management of breast cancer in older and frail patients.
abstract: Almost 50% of breast cancer occurs in women over the age of 65 years. The incidence of non standard adjuvant treatment increases with age and this group are under represented in clinical trials. We discuss tools to aid patient selection and adjuvant treatments including surgery, radiotherapy and systemic therapies for this group of patients.
authors: The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, United Kingdom. Electronic address: Ian.Smith@rmh.nhs.uk.
authors: Ian E
authors: IE
authors: Smith
authors: The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, United Kingdom.
authors: Charlotte
authors: C
authors: Fribbens
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D005260:Female; D016330:Frail Elderly; D006801:Humans; D015412:Mastectomy, Segmental; D018579:Patient Selection; D018714:Radiotherapy, Adjuvant; D000068878:Trastuzumab / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000068878:Trastuzumab
keywords: Breast cancer; Chemotherapy; Elderly; Endocrine therapy; Radiotherapy; Surgery