title: Hemophilus Influenzae Infections with Abscess Formation in Adults: a Retrospective Study Covering an Eleven-Year Period.
abstract: BACKGROUND
  The aim of this study was to investigate the presence of Haemophilus influenzae in abscesses in adults and to determine their antibiotic resistance patterns.
  
  
  METHODS
  H. influenzae strains isolated from abscesses during an eleven-year period were determined retrospectively and the stored strains were tested for ampicillin, amoxicillin/calvulanic acid, cefuroxime, cefotaxime, ceftriaxone, ciprofloxacin, azithromycin, tetracycline, and imipenem resistance by broth microdilution method. The production of β-lactamase was detected using the nitrocefin disc test and real-time PCR.
  
  
  RESULTS
  A total of 26 H. influenzae isolated strains were found. According to ampicillin resistance and β-lactamase production, 2 strains were determined as BLPAR, 1 strain BLNAR, 1 strain BLPACR, and 22 strains as BLNAS. Cefuroxime resistance was detected in 4 strains, tetracycline resistance was detected in 4 strains, and no resistance to cefotaxime, ceftriaxone, imipenem, azithromycin and levofloxacin was detected.
  
  
  CONCLUSIONS
  H. influenzae should be taken into account for the proper management of abscesses.
authors: Muzeyyen Mamal
authors: MM
authors: Torun
authors: Hrisi Bahar
authors: HB
authors: Tokman
authors: Mehmet
authors: M
authors: Demirci
authors: Sinem
authors: S
authors: Ozdemir
authors: Serdar M
authors: SM
authors: Altinkum
authors: Hatice
authors: H
authors: Cilingir
authors: Filiz Yarimcam
authors: FY
authors: Saglam
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000235:genetics; D052978:Disk Diffusion Antimicrobial Tests; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005838:Genotype; D006192:Haemophilus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006193:Haemophilus influenzae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D010641:Phenotype; D060888:Real-Time Polymerase Chain Reaction; D012189:Retrospective Studies; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D001618:beta-Lactamases