title: Transition-Metal-Free Dehydrosilylative Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions.
abstract: Disclosed herein is a dehydrosilylative difluoroamidation of α-Csp(3)-H of tetrahydroisoquinolines with α,α-difluoro-α-TMS-acetamides. The process, which occurs at ambient temperature in the absence of any transition metals, provides direct access to a broad range of α,α-difluoroacetamide-substituted tertiary amine derivatives in high yields. Moreover, the method was successfully applied in the Csp(3)-H-directed difluorophosphorylation and difluorocarboxylation under the same conditions.
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors: Qiao
authors: Q
authors: Chen
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors: Jiawei
authors: J
authors: Zhou
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors: Yanan
authors: Y
authors: Wang
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors: Chao
authors: C
authors: Wang
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors: Xihong
authors: X
authors: Liu
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors: Zhaoqing
authors: Z
authors: Xu
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors: Li
authors: L
authors: Lin
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors: Rui
authors: R
authors: Wang
mesh_terms: D000081:Acetamides / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000081:Acetamides; D006845:Hydrocarbons, Fluorinated; D044005:Tetrahydroisoquinolines