title: Indocyanine Green Derivative Covalently Conjugated with Gold Nanorods for Multimodal Phototherapy of Fibrosarcoma Cells.
abstract: A hydrophilic indocyanine green derivative (ICG-Der-02) was covalently doped into mesoporous silica-coated gold nanorods (AuNRs/mSiO2). The self-synthesized derivative offers one carboxyl functional group on a side chain, which enables ICG-Der-02 to be covalently linked to nanomaterials and reduces the probability of leakage/desorption of the dye. The detection of infrared luminescence around 1270 nm confirmed that 102 is efficiently generated by the nanocomposite (AuNRs/mSiO2-ICG-Der-02). Furthermore, a second layer of silica was coated onto the nanocomposite, which then was conjugated with the α(v) integrin-targeting cyclic peptide (RGD-4C). The cell tests showed that the resulting nanoconjugate (AuNRs/mSiO2-ICG-Der-02/RGD-4C) was able to bind preferentially to HT-1080 human fibrosarcoma cells. Due to the synergistic effect of the produced nanoconjugates, a dual-modality photothermal and photochemical therapy was successfully achieved by 808 nm irradiation. Compared to using photothermal or photochemical therapy alone, the dual-modality photothermal/photochemical therapeutic strategy proved to be more damaging to HT-1080 cells and enhanced the effectiveness of photodestruction. Our work presents a novel approach to the multimodal treatment of fibrosarcoma and shows promise for future use in cancer theranostics.
authors: Teng
authors: T
authors: Luo
authors: Xiaoqing
authors: X
authors: Qian
authors: Zhiyong
authors: Z
authors: Lu
authors: Yiwen
authors: Y
authors: Shi
authors: Zhirong
authors: Z
authors: Yao
authors: Xinyu
authors: X
authors: Chai
authors: Qiushi
authors: Q
authors: Ren
mesh_terms: D045744:Cell Line, Tumor; D005354:Fibrosarcoma / Q000628:therapy*; D005434:Flow Cytometry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry*; D007834:Lasers; D009682:Magnetic Resonance Spectroscopy; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine / Q000379:methods; D043942:Nanotubes / Q000737:chemistry*; D010789:Phototherapy / Q000379:methods*; D015203:Reproducibility of Results; D026082:Singlet Oxygen / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D026082:Singlet Oxygen; D006046:Gold; D007208:Indocyanine Green