title: Formal total synthesis of (+)-cortistatins A and J.
abstract: An efficient formal total synthesis of (+) cortistatins A and J has been accomplished, by exploiting a highly diastereoselective intramolecular [4+3] cycloaddition of epoxy enolsilanes as the key reaction to construct rings B and C of the cortistatins in one step.
authors: Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (P. R. China).
authors: Liping
authors: L
authors: Kuang
authors: Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (P. R. China).
authors: Lok Lok
authors: LL
authors: Liu
authors: Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (P. R. China). pchiu@hku.hk.
authors: Pauline
authors: P
authors: Chiu
mesh_terms: D061565:Cycloaddition Reaction; D004852:Epoxy Compounds / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004852:Epoxy Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; D007546:Isoquinolines; D011083:Polycyclic Compounds; D012821:Silanes; C531521:cortistatin A; C545305:cortistatin J
keywords: [4+3] cycloaddition; alkaloids; cortistatins; natural products; total synthesis