title: Advances in cancer pain from bone metastasis.
abstract: With the technological advances in cancer diagnosis and treatment, the survival rates for patients with cancer are prolonged. The issue of figuring out how to improve the life quality of patients with cancer has become increasingly prominent. Pain, especially bone pain, is the most common symptom in malignancy patients, which seriously affects the life quality of patients with cancer. The research of cancer pain has a breakthrough due to the development of the animal models of cancer pain in recent years, such as the animal models of mouse femur, humerus, calcaneus, and rat tibia. The establishment of several kinds of animal models related to cancer pain provides a new platform in vivo to investigate the molecular mechanisms of cancer pain. In this review, we focus on the advances of cancer pain from bone metastasis, the mechanisms involved in cancer pain, and the drug treatment of cancer pain in the animal models.
authors: College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, People's Republic of China.
authors: Xiao-Cui
authors: XC
authors: Zhu
authors: College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, People's Republic of China.
authors: Jia-Li
authors: JL
authors: Zhang
authors: College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, People's Republic of China.
authors: Chen-Tao
authors: CT
authors: Ge
authors: College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, People's Republic of China.
authors: Yuan-Yang
authors: YY
authors: Yu
authors: College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, People's Republic of China.
authors: Pan
authors: P
authors: Wang
authors: School of Psychology, Nanjing Normal University, Nanjing, People's Republic of China.
authors: Ti-Fei
authors: TF
authors: Yuan
authors: College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, People's Republic of China ; Institute for Cell-Based Drug Development of Zhejiang Province, Hangzhou, People's Republic of China.
authors: Cai-Yun
authors: CY
authors: Fu
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D001859:Bone Neoplasms / Q000150:complications* / Q000556:secondary*; D059390:Breakthrough Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004059:Diffusion of Innovation; D004195:Disease Models, Animal; D055808:Drug Discovery; D006801:Humans; D058990:Molecular Targeted Therapy; D059408:Pain Management / Q000639:trends*; D010147:Pain Measurement; D058748:Pain Perception / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D011788:Quality of Life; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000700:Analgesics
keywords: animal models of cancer pain; cancer pain from bone metastasis; drug treatment; molecular mechanisms