title: Identification of similarities and differences between myeloid and lymphoid acute leukemias using a gene-gene interaction network.
abstract: Acute myeloid leukemia (AML) is a cancer that affects the myeloid line of blood cells. Acute lymphoid leukemia (ALL) is a type of leukemia that targets the lymphoid line of blood cells. As the comparison of these two types facilitates in the understanding of their molecular pathology, exploring the similarities and differences in the mechanisms of them is worthwhile. We identified 28 novel AML- and ALL-related genes shared in both of them using a short path algorithm. By integrating gene ontology (GO) and KEGG pathway annotations, we revealed the underlying molecular features of AML and ALL. We finally obtained 160 optimal GO terms that could satisfactorily distinguish two types. Further analysis revealed that the results agree well with previous knowledge. Determining the common and different features between AML and ALL facilitates the classification of leukemia and is thus clinically relevant for exploring the molecular markers.
authors: Nursing College of Zhengzhou University, Zhengzhou 450052, China. Electronic address: chj@zzu.edu.cn.
authors: Jing
authors: J
authors: Chen
authors: Nursing College of Zhengzhou University, Zhengzhou 450052, China. Electronic address: huangcaihui@126.com.
authors: Caihui
authors: C
authors: Huang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: zhuyc123@163.com.
authors: Yingchao
authors: Y
authors: Zhu
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: dongli371@163.com.
authors: Li
authors: L
authors: Dong
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: caoweijie2003@126.com.
authors: Weijie
authors: W
authors: Cao
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: sunling6686@126.com.
authors: Ling
authors: L
authors: Sun
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: sunhui371@medmail.com.
authors: Hui
authors: H
authors: Sun
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: wandingming@zzu.edu.cn.
authors: Dingming
authors: D
authors: Wan
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: liuyf371@163.com.
authors: Yanfang
authors: Y
authors: Liu
authors: Nursing College of Zhengzhou University, Zhengzhou 450052, China. Electronic address: zhangzx6666@126.com.
authors: Zhenxiang
authors: Z
authors: Zhang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: wang62073@aliyun.com.
authors: Chong
authors: C
authors: Wang
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D053263:Gene Regulatory Networks; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*
chemical_list: D015703:Antigens, CD
keywords: Acute lymphoid leukemia; Acute myeloid leukemia; Classification of leukemia