title: Clinical Research Informatics: Recent Advances and Future Directions.
abstract: OBJECTIVE
  To summarize significant developments in Clinical Research Informatics (CRI) over the past two years and discuss future directions.
  
  
  METHODS
  Survey of advances, open problems and opportunities in this field based on exploration of current literature.
  
  
  RESULTS
  Recent advances are structured according to three use cases of clinical research: Protocol feasibility, patient identification/ recruitment and clinical trial execution.
  
  
  CONCLUSIONS
  CRI is an evolving, dynamic field of research. Global collaboration, open metadata, content standards with semantics and computable eligibility criteria are key success factors for future developments in CRI.
authors: Prof. Dr. Martin Dugas, Institute of Medical Informatics, University of Münster, Albert-Schweitzer-Campus 1 | A11, D-48149 Münster, Germany, Tel: +49 251 83 55262, E-mail: dugas@uni-muenster.de.
authors: M
authors: M
authors: Dugas
mesh_terms: D035843:Biomedical Research / Q000458:organization & administration; D002986:Clinical Trials as Topic / Q000458:organization & administration; D004282:Documentation; D057286:Electronic Health Records; D016247:Information Storage and Retrieval; D008490:Medical Informatics; D018511:Systems Integration
keywords: Clinical research informatics; clinical trial execution; open metadata; patient recruitment; protocol feasibility; semantic annotation