title: Techniques to elucidate the conformation of prions.
abstract: Proteinaceous infectious particles (prions) are unique pathogens as they are devoid of any coding nucleic acid. Whilst it is assumed that prion disease is transmitted by a misfolded isoform of the cellular prion protein, the structural insight of prions is still vague and research for high resolution structural information of prions is still ongoing. In this review, techniques that may contribute to the clarification of the conformation of prions are presented and discussed.
authors: Martin L Daus, ZBS6 - Proteomics and Spectroscopy, Robert Koch-Institute, 13353 Berlin, Germany.
authors: Martin L
authors: ML
authors: Daus
keywords: Amyloid; Fourier-transform infrared spectroscopy; Neurodegenerative disease; Prion; Protein structure