title: Comparison of anti-inflammatory effect of atorvastatin with rosuvastatin in patients of acute coronary syndrome.
abstract: OBJECTIVE
  To compare anti-inflammatory effect of atorvastatin and rosuvastatin in patients of acute coronary syndrome.
  
  
  METHODS
  The study was a prospective, open-labeled, randomized and single-center study conducted on 100 patients of acute coronary syndrome. Patients were assigned to atorvastatin 40 mg daily or rosuvastatin 20 mg daily for 4 weeks. C-reactive protein (CRP) levels, lipid profiles, erythrocyte sedimentation rate (ESR) and adverse effects were measured at beginning and at the end of 4 weeks.
  
  
  RESULTS
  Baseline parameters and clinical profile did not differ between the two groups. CRP levels significantly decreased from beginning to the end of 4 weeks in both atorvastatin and rosuvastatin groups (from 35.48 to 23.07 mg/l and from 35.88 to 19.91 mg/l respectively, both P < 0.001). However, there was significant difference between the levels of CRP in patients of the rosuvastatin group as compared to the atorvastatin group (19.91 ± 6.32 vs 23.07 ± 7.47, P < 0.05). In addition, both the drugs were associated with a reduction in total cholesterol, LDL levels and ESR at the end of 4 weeks as compared to the beginning (P < 0.001 for all comparisons).
  
  
  CONCLUSIONS
  Both atorvastatin (40 mg) and rosuvastatin (20 mg) are effective in decreasing CRP and LDL cholesterol levels even in a short duration of 4 weeks. Rosuvastatin was found to be more effective in decreasing CRP levels.
authors: Department of Pharmacology, Subharti Medical College, Meerut, Uttar Pradesh, India.
authors: Sushant
authors: S
authors: Khurana
authors: Department of Pharmacology, Subharti Medical College, Meerut, Uttar Pradesh, India.
authors: Surabhi
authors: S
authors: Gupta
authors: Department of Pharmacology, Subharti Medical College, Meerut, Uttar Pradesh, India.
authors: HiraLal
authors: H
authors: Bhalla
authors: Department of Medicine, Subharti Medical College, Meerut, Uttar Pradesh, India.
authors: Shefali
authors: S
authors: Nandwani
authors: Department of Medicine, Subharti Medical College, Meerut, Uttar Pradesh, India.
authors: Varad
authors: V
authors: Gupta
keywords: Acute coronary syndrome; inflammation; statins