title: Effectiveness of nano-calcium phosphate paste on sensitivity during and after bleaching: a randomized clinical trial.
abstract: The study aimed to evaluate the effectiveness of in-office bleaching and associated tooth sensitivity on application of nano-calcium phosphate paste as desensitizing agent. Bleaching was performed with 35% hydrogen peroxide gel in 40 patients who were randomly divided into placebo and nano-calcium phosphate paste groups. Bleaching efficacy (BE) was evaluated using a value-oriented Vita shade guide. Tooth sensitivity was recorded using a numeric rating scale (0-4) during bleaching and up to 48 h after each session. The primary outcome of absolute risk of tooth sensitivity was compared using the Fisher's exact test (α = 0.05). The intensity of tooth sensitivity and the efficacy of in-office bleaching were also statistically evaluated. No significant differences in absolute risk and intensity of tooth sensitivity were detected between the groups (p = 1.0 and p = 0.53, respectively). BE was also found to be similar between the groups (p = 0.67). Although the use of a nano-calcium phosphate paste associated with fluoride and potassium nitrate did not influence the whitening outcome, but it also did not reduce bleaching-induced tooth sensitivity.
authors: Department of Restorative Dentistry, School of Dentistry, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, BR.
authors: Alessandro Dourado
authors: AD
authors: Loguercio
authors: Department of Restorative Dentistry, Universidad Peruana Cayetano Heredia, Lima, PE.
authors: Lidia Yileng
authors: LY
authors: Tay
authors: Department of Restorative Dentistry, School of Dentistry of Piracicaba, University of Campinas, Piracicaba, SP, BR.
authors: Daniel Rodrigo
authors: DR
authors: Herrera
authors: Department of Dentistry I, School of Dentistry, Universidade Federal do Maranhão, São Luís, MA, BR.
authors: Jose
authors: J
authors: Bauer
authors: Department of Restorative Dentistry, School of Dentistry, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, BR.
authors: Alessandra
authors: A
authors: Reis
mesh_terms: D000328:Adult; D002130:Calcium Phosphates / Q000008:administration & dosage* / Q000009:adverse effects; D057133:Dentin Desensitizing Agents / Q000008:administration & dosage*; D003807:Dentin Sensitivity / Q000139:chemically induced*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D009566:Nitrates / Q000008:administration & dosage* / Q000009:adverse effects; D017680:Potassium Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D014073:Tooth Bleaching / Q000009:adverse effects* / Q000379:methods; D058205:Tooth Bleaching Agents / Q000008:administration & dosage* / Q000009:adverse effects; D014075:Tooth Discoloration / Q000188:drug therapy; D055815:Young Adult
chemical_list: D002130:Calcium Phosphates; D057133:Dentin Desensitizing Agents; D009566:Nitrates; D017680:Potassium Compounds; D058205:Tooth Bleaching Agents; C020243:calcium phosphate; D006861:Hydrogen Peroxide; C023844:potassium nitrate