title: Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 2: Radiolabeled Probes.
abstract: Nanoparticulate imaging agents and therapeutics have proven to be valuable tools in preclinical cardiovascular disease research. Because of their distinct properties and significant functional versatility, nanoparticulate imaging agents afford certain capabilities that are typically not provided by traditional small molecule agents. This review is the second in a two-part series covering nanoparticulate imaging agents and theranostics. It highlights current examples of radiolabeled nanoparticulate probes in preclinical cardiovascular research and demonstrates their utility in applications such as blood pool imaging and molecular imaging of ischemia, angiogenesis, atherosclerosis, and inflammation. These agents provide valuable insight into the molecular and cellular mechanisms of cardiovascular disease and illustrate both the limitations and the significant potential of nanoparticles in diagnostic and therapeutic applications. Further technologic development to improve performance, address safety concerns, and fulfil regulatory obligations is required for clinical translation of these emergent technologies.
authors: Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut Yale Translational Research Imaging Center, Yale University School of Medicine, New Haven, Connecticut; and.
authors: John C
authors: JC
authors: Stendahl
authors: Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut Yale Translational Research Imaging Center, Yale University School of Medicine, New Haven, Connecticut; and Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut albert.sinusas@yale.edu.
authors: Albert J
authors: AJ
authors: Sinusas
mesh_terms: D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D016503:Drug Delivery Systems; D015637:Gated Blood-Pool Imaging; D006801:Humans; D057054:Molecular Imaging; D053758:Nanoparticles; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000627:therapeutic use*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals
keywords: PET; SPECT; cardiovascular disease; molecular imaging; nanoparticles