title: Inclusion complexation between baicalein and β-cyclodextrin and the influence of β-cyclodextrin on the binding of baicalein with DNA: a spectroscopic approach.
abstract: This work deals with the commonly studied cyclic oligosaccharide and gains importance as it is entered on a drug delivering carbohydrate and provides insight into the oligosaccharide complex-biomolecular interaction. The binding of a flavone, baicalein, to β-cyclodextrin and calf thymus DNA is studied. The binding of baicalein to calf thymus DNA in the presence of β-cyclodextrin is analysed using the UV-vis absorption and fluorescence spectroscopy. The mode of binding and structure of the baicalein-β-cyclodextrin complex are reported. The role of the structure and the stoichiometry of the inclusion complex of baicalein-β-cyclodextrin in its influence on DNA binding are analysed. Highlights • This paper deals with the binding of a flavone, baicalein to β-cyclodextrin and/or DNA. • The inclusion complexation between baicalein and β-cyclodextrin is analysed. • The stoichiometry and the binding strength of the inclusion complex is reported. • The role of β-cyclodextrin in tuning the binding of baicalein to DNA is emphasized. • Spectroscopic and docking analysis are used to articulate the results.
authors: a Department of Chemistry, School of Science and Humanities , Karunya University , Coimbatore , Tamil Nadu 641 114 , India.
authors: Yousuf
authors: Y
authors: Sameena
authors: a Department of Chemistry, School of Science and Humanities , Karunya University , Coimbatore , Tamil Nadu 641 114 , India.
authors: Sowrirajan
authors: S
authors: Chandrasekaran
authors: a Department of Chemistry, School of Science and Humanities , Karunya University , Coimbatore , Tamil Nadu 641 114 , India.
authors: Enoch
authors: E
authors: Israel V M V
mesh_terms: D004247:DNA / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry*; D008968:Molecular Conformation; D062105:Molecular Docking Simulation; D066244:Proton Magnetic Resonance Spectroscopy; D013057:Spectrum Analysis; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D044950:Flavanones; D047392:beta-Cyclodextrins; C006680:baicalein; D004247:DNA
keywords: baicalein; calf thymus DNA; fluorescence spectroscopy; β-cyclodextrin