title: Rationale for a Helicobacter pylori Test and Treatment Strategy in Gastroesophageal Reflux Disease.
abstract: Conflicting data have been published on the effect of long-term proton pump inhibitor therapy on the gastric mucosa in Helicobacter pylori-infected subjects. In this article, the available data are reviewed and a rationale is offered for why infected patients who are about to commence long-term proton pump inhibitor therapy should be offered eradication therapy.
authors: University of Wisconsin School of Medicine and Public Health, 750 Highland Avenue, Madison, WI 53726, USA; Aurora Summit Medical Center, 36500 Aurora Drive, Summit, WI 53066, USA. Electronic address: nvakil@wisc.edu.
authors: Nimish
authors: N
authors: Vakil
mesh_terms: D000230:Adenocarcinoma / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D054328:Proton Pump Inhibitors
keywords: GERD; Gastric atrophy; H pylori; Intestinal metaplasia; Proton pump inhibitors