title: Correlation of caveolin-1 expression with microlymphatic vessel density in colorectal adenocarcinoma tissues and its correlation with prognosis.
abstract: OBJECTIVE
  To study the expression of caveolin-1 in colorectal adenocarcinoma tissues and its correlation with microlymphatic vessel density (LMVD), and to investigate the clinical pathological prognostic significance of caveolin-1 and LMVD in patients with colorectal cancer.
  
  
  METHODS
  The expression of caveolin-1 and LMVD in 45 specimens of normal colorectal tissues, and 90 specimens of colorectal adenocarcinoma tissues were detected by immunohistochemistry technique. The correlation between their expression and the clinicopathologic features was analyzed. Multivariable Cox regression was used to analyze the association between the laboratory indices and overall survival time.
  
  
  RESULTS
  The positive rates of caveolin-1 in colorectal adenocarcinoma tissues were significantly higher than those in normal colorectal tissues (P < 0.01). LMVD in colorectal adenocarcinoma tissues were significantly higher than those in normal colorectal tissues (P < 0.01). Mean LMVD in group with caveolin-1 positive was significantly higher than in that with caveolin-1 negative. The median survival time was 26.7 months. Cox regression analysis showed that the caveolin-1 expression, invation depth, lymph node metastasis, TNM stage, liver metastasis and LMVD were independent risk factors of overall survival time of patients with colorectal carcinoma.
  
  
  CONCLUSIONS
  Caveolin-1 may contribute to the lymphangiogenesis in the tumor. During the occurrence and development of colorectal adenocarcinoma, there is a close relationship between the expression of caveolin-1 and lymphatic microvessel of tumor. Caveolin-1 expression and microlymphatic vessel density are significant prognostic value of colorectal carcinoma.
authors: First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China. Electronic address: yfywlkwxl@126.com.
authors: Jun
authors: J
authors: Xue
authors: First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
authors: Xue-Liang
authors: XL
authors: Wu
authors: First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
authors: Xian-Tao
authors: XT
authors: Huang
authors: First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
authors: Fei
authors: F
authors: Guo
authors: First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
authors: Hong-Feng
authors: HF
authors: Yu
authors: First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
authors: Peng-Cheng
authors: PC
authors: Zhang
authors: First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
authors: Li-Kun
authors: LK
authors: Wang
authors: First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
authors: Ming
authors: M
authors: Qu
authors: First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
authors: Li-Ming
authors: LM
authors: Pan
keywords: Caveolin-1; Colorectal neoplasms; Immunohistochemistry; Microlymphatic density