title: Comparison of rates of retinal nerve fibre layer thinning between patients with non-myopic and myopic glaucoma.
abstract: OBJECTIVE
  To compare the rates of retinal nerve fibre layer (RNFL) thinning in subgroups of patients with glaucoma based on spherical equivalent (SE).
  
  
  METHODS
  In this retrospective study, patients were classified into three subgroups, namely, non-myopic glaucoma (NMG, >0 dioptres (D)), mild-to-moderate glaucoma (MMG, 0 to -6 D) and highly myopic glaucoma (HMG,<-6 D), according to their SE. Linear mixed effects models were used to evaluate the rate of change of RNFL thickness determined by spectral domain optical coherence tomography, adjusting for potentially confounding factors.
  
  
  RESULTS
  Among 231 glaucomatous eyes from 231 patients (mean followed up 4.5 years), 105 (45.5%) were classified as NMG, 100 (43.2%) as MMG and 26 (11.3%) as HMG. Baseline visual field mean deviation did not differ among the three subgroups (-4.15 vs -5.44 dB vs -4.38 dB, p=0.185). Thinning rate of average RNFL did not differ among the three subgroups (-0.58, -0.52 and -0.54 μm/year, p=0.931). However, RNFL thinning rate at temporal quadrant (-0.85 vs -0.23 μm/year, p=0.046) and eight o'clock sector was greater in the HMG than in the NMG subgroups (-1.72 vs -0.35 μm/year, p=0.003), while that of one o'clock sector was greater in the NMG than in the HMG subgroups (-0.93 vs 0.45 μm/year, p=0.009).
  
  
  CONCLUSIONS
  Overall rate of RNFL thinning was not different among the glaucoma subgroups based on refractive error. However, sectoral RNFL thinning showed significant difference.
authors: Department of Ophthalmology, Center for Medical Research and Information, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
authors: Jin Young
authors: JY
authors: Lee
authors: Department of Ophthalmology, Center for Medical Research and Information, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
authors: Kyung Rim
authors: KR
authors: Sung
authors: Division of Biostatistics, Center for Medical Research and Information, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
authors: Sung-Cheol
authors: SC
authors: Yun
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000503:physiopathology*; D009412:Nerve Fibers / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields / Q000502:physiology
keywords: Glaucoma; Imaging; Optic Nerve