title: Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.
abstract: Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.
authors: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. wjj100@163.com.
authors: Jun
authors: J
authors: Wang
authors: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. songyongxi840309@126.com.
authors: Yong-Xi
authors: YX
authors: Song
authors: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. mabin0326cmu@163.com.
authors: Bin
authors: B
authors: Ma
authors: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. wjj100@163.com.
authors: Jia-Jun
authors: JJ
authors: Wang
authors: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. sun2003999@163.com.
authors: Jing-Xu
authors: JX
authors: Sun
authors: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. chenxiaowan1826@163.com.
authors: Xiao-Wan
authors: XW
authors: Chen
authors: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. zjh900521@163.com.
authors: Jun-Hua
authors: JH
authors: Zhao
authors: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. yangyuchong1987@126.com.
authors: Yu-Chong
authors: YC
authors: Yang
authors: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China. josieon826@sina.cn.
authors: Zhen-Ning
authors: ZN
authors: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009154:Mutation; D022661:RNA, Untranslated / Q000037:antagonists & inhibitors / Q000145:classification / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D022661:RNA, Untranslated
keywords: biomarkers; colorectal cancer; dysregulation; non-coding RNAs; targets