title: A computational tool for patient specific dosimetry and radiobiological modeling of selective internal radiation therapy with (90)Y microspheres.
abstract: In recent years we have witnessed tremendous progress in selective internal radiation therapy. In clinical practice, quite often, radionuclide therapy is planned using simple models based on standard activity values or activity administered per unit body weight or surface area in spite of the admission that radiation-dose methods provide more accurate dosimetric results. To address that issue, the authors developed a Matlab-based computational software, named Patient Specific Yttrium-90 Dosimetry Toolkit (PSYDT). PSYDT was designed for patient specific voxel-based dosimetric calculations and radiobiological modeling of selective internal radiation therapy with (90)Y microspheres. The developed toolkit is composed of three dimensional dose calculations for both bremsstrahlung and beta emissions. Subsequently, radiobiological modeling is performed on a per-voxel basis and cumulative dose volume histograms (DVHs) are generated. In this report we describe the functionality and visualization features of PSYDT.
authors: Florida Atlantic University, Department of Physics, Boca Raton, FL 33431, United States.
authors: Georgios
authors: G
authors: Kalantzis
authors: Florida Atlantic University, Department of Physics, Boca Raton, FL 33431, United States.
authors: Theodora
authors: T
authors: Leventouri
authors: Memorial Sloan Kettering Cancer Center, Department of Medical Physics, NY 10065, United States.
authors: Aditiya
authors: A
authors: Apte
authors: Florida Atlantic University, Department of Physics, Boca Raton, FL 33431, United States; Lynn Cancer Institute, Department of Radiation Oncology, Boca Raton, FL 33486, United States.
authors: Charles
authors: C
authors: Shang
mesh_terms: D001918:Brachytherapy / Q000706:statistics & numerical data*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000532:radiotherapy; D004621:Embolization, Therapeutic / Q000706:statistics & numerical data; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000706:statistics & numerical data; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D066230:Patient-Specific Modeling / Q000706:statistics & numerical data*; D049268:Positron-Emission Tomography; D011853:Radiobiology / Q000706:statistics & numerical data; D011874:Radiometry / Q000706:statistics & numerical data; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data*; D014057:Tomography, X-Ray Computed; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes
keywords: Dosimetry; Matlab Toolkit; Micropsheres; Selective internal therapy