title: TRIM28 as a novel transcriptional elongation factor.
abstract: TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation. TRIM28 was shown to stabilize the pausing of RNA polymerase II (Pol II) close to the transcriptional start site in many unactivated genes, permitting Pol II accumulation and readying genes for induction. In addition, the factor was shown to respond rapidly to signals accompanying transcriptional activation permitting the productive elongation of RNA by previously paused Pol II. We discuss here critical regulatory mechanisms of TRIM28 in transcriptional control and DNA repair that may illuminate the novel roles of this factor in pausing and elongation of Pol II.
authors: Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Sciences, 3 Blackfan circle, Boston, MA, 02115, USA. hbunch@bidmc.harvard.edu.
authors: Heeyoun
authors: H
authors: Bunch
authors: Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Sciences, 3 Blackfan circle, Boston, MA, 02115, USA. scalderw@bidmc.harvard.edu.
authors: Stuart K
authors: SK
authors: Calderwood
mesh_terms: D000818:Animals; D001665:Binding Sites; D004260:DNA Repair; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism*; D012097:Repressor Proteins / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic; D035602:Transcriptional Elongation Factors / Q000737:chemistry / Q000378:metabolism; D000076183:Tripartite Motif-Containing Protein 28
chemical_list: D012097:Repressor Proteins; D035602:Transcriptional Elongation Factors; C101116:TRIM28 protein, human; D000076183:Tripartite Motif-Containing Protein 28; D012319:RNA Polymerase II