title: Associations Between Mild Cognitive Impairment and Hospitalization and Readmission.
abstract: OBJECTIVE
  To determine whether older adults with mild cognitive impairment (MCI), a condition not previously explored as a risk factor, have more hospitalizations and 30-day readmissions than those with normal cognition.
  
  
  METHODS
  Post hoc analysis of prospectively gathered data on incident hospitalization and readmission from the Ginkgo Evaluation of Memory Study (GEMS), a randomized, double-blind, placebo-controlled trial designed to assess the effect of Ginkgo biloba on incidence of dementia.
  
  
  METHODS
  GEMS was conducted in five academic medical centers in the United States.
  
  
  METHODS
  Community-dwelling adults aged 75 and older with normal cognition (n = 2,314) or MCI (n = 428) at baseline cognitive testing (N = 2,742).
  
  
  METHODS
  Index hospitalization and 30-day hospital readmission, adjusted for age, sex, race, education, clinic site, trial assignment status, comorbidities, number of prescription medications, and living with an identified proxy.
  
  
  RESULTS
  MCI was associated with a 17% greater risk of index hospitalization than normal cognition (adjusted hazard ratio (aHR) = 1.17, 95% confidence interval (CI) = 1.02-1.34)). In participants who lived with a proxy, MCI was associated with a 39% greater risk of index hospitalization (aHR = 1.39, 95% CI = 1.17-1.66). Baseline MCI was not associated with greater odds of 30-day hospital readmission (adjusted odds ratio = 0.90, 95% CI = 0.60-1.36).
  
  
  CONCLUSIONS
  MCI may represent a target condition for healthcare providers to coordinate support services in an effort to reduce hospitalization and subsequent disability.
authors: Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, North Carolina.|Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
authors: Kathryn E
authors: KE
authors: Callahan
authors: Department of Biostatistical Sciences, Wake Forest University, Winston-Salem, North Carolina.
authors: James F
authors: JF
authors: Lovato
authors: Department of Biostatistical Sciences, Wake Forest University, Winston-Salem, North Carolina.
authors: Michael E
authors: ME
authors: Miller
authors: Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina.
authors: Doug
authors: D
authors: Easterling
authors: Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors: Beth
authors: B
authors: Snitz
authors: Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, North Carolina.|Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
authors: Jeff D
authors: JD
authors: Williamson
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000453:epidemiology*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D010359:Patient Readmission / Q000706:statistics & numerical data*; D011446:Prospective Studies
keywords: acute hospital utilization; mild cognitive impairment; rehospitalization