title: Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target.
abstract: OBJECTIVE
  The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) program was initiated by the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD). It examined potential treatment targets for inflammatory bowel disease (IBD) to be used for a "treat-to-target" clinical management strategy using an evidence-based expert consensus process.
  
  
  METHODS
  A Steering Committee of 28 IBD specialists developed recommendations based on a systematic literature review and expert opinion. Consensus was gained if ≥75% of participants scored the recommendation as 7-10 on a 10-point rating scale (where 10=agree completely).
  
  
  RESULTS
  The group agreed upon 12 recommendations for ulcerative colitis (UC) and Crohn's disease (CD). The agreed target for UC was clinical/patient-reported outcome (PRO) remission (defined as resolution of rectal bleeding and diarrhea/altered bowel habit) and endoscopic remission (defined as a Mayo endoscopic subscore of 0-1). Histological remission was considered as an adjunctive goal. Clinical/PRO remission was also agreed upon as a target for CD and defined as resolution of abdominal pain and diarrhea/altered bowel habit; and endoscopic remission, defined as resolution of ulceration at ileocolonoscopy, or resolution of findings of inflammation on cross-sectional imaging in patients who cannot be adequately assessed with ileocolonoscopy. Biomarker remission (normal C-reactive protein (CRP) and calprotectin) was considered as an adjunctive target.
  
  
  CONCLUSIONS
  Evidence- and consensus-based recommendations for selecting the goals for treat-to-target strategies in patients with IBD are made available. Prospective studies are needed to determine how these targets will change disease course and patients' quality of life.
authors: INSERM Unité 954 and Department of Hepato-Gastroenterology, University Hospital of Nancy, University of Lorraine, Houdemont, France.
authors: L
authors: L
authors: Peyrin-Biroulet
authors: Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.
authors: W
authors: W
authors: Sandborn
authors: Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors: B E
authors: BE
authors: Sands
authors: McMaster University, Hamilton, Ontario, Canada.|Medical University of Vienna, Vienna, Austria.
authors: W
authors: W
authors: Reinisch
authors: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors: W
authors: W
authors: Bemelman
authors: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK.
authors: R V
authors: RV
authors: Bryant
authors: Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands.
authors: G
authors: G
authors: D'Haens
authors: Inflammatory Bowel Disease Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: I
authors: I
authors: Dotan
authors: Division of Pediatric Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors: M
authors: M
authors: Dubinsky
authors: University of Western Ontario, London, Ontario, Canada.
authors: B
authors: B
authors: Feagan
authors: Inflammatory Bowel Disease Center, Department of Gastroenterology, Humanitas Research Hospital, Rozzano, Milan, Italy.
authors: G
authors: G
authors: Fiorino
authors: Department of Medicine, University of Otago, Christchurch, New Zealand.
authors: R
authors: R
authors: Gearry
authors: Columbia University Division of Digestive and Liver Diseases, New York, New York, USA.
authors: S
authors: S
authors: Krishnareddy
authors: First Department of Medicine, Semmelweis University, Budapest, Hungary.
authors: P L
authors: PL
authors: Lakatos
authors: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
authors: E V
authors: EV
authors: Loftus
authors: AP-HP, Department of Digestive Diseases, Hôpital Lariboisière Medicosurgical and University Denis Diderot, Paris, France.
authors: P
authors: P
authors: Marteau
authors: North Zealand Hospital, Capital Region, University of Copenhagen, Copenhagen, Denmark.
authors: P
authors: P
authors: Munkholm
authors: Inflammatory Bowel Disease Group, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
authors: T B
authors: TB
authors: Murdoch
authors: Department of Gastroenterology, Hospital Clinic of Barcelona, IDIBAPS, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
authors: I
authors: I
authors: Ordás
authors: Inflammatory Bowel Disease Clinic University of Calgary, Calgary, Alberta, Canada.
authors: R
authors: R
authors: Panaccione
authors: Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors: R H
authors: RH
authors: Riddell
authors: Division of Gastroenterology, CHU Sherbrooke, Sherbrooke, Quebec, Canada.
authors: J
authors: J
authors: Ruel
authors: Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, Illinois, USA.
authors: D T
authors: DT
authors: Rubin
authors: Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands.
authors: M
authors: M
authors: Samaan
authors: Dartmouth-Hitchcock Inflammatory Bowel Disease Center, Hanover, New Hampshire, USA.
authors: C A
authors: CA
authors: Siegel
authors: Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
authors: M S
authors: MS
authors: Silverberg
authors: Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: J
authors: J
authors: Stoker
authors: Department of General Internal Medicine, Christian-Albrechts-University, University Hospital Schleswig Holstein, Kiel, Germany.
authors: S
authors: S
authors: Schreiber
authors: Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK.
authors: S
authors: S
authors: Travis
authors: Division of Gastroenterology, University of Leuven, Leuven, Belgium.|University of Toronto, Toronto, Ontario, Canada.
authors: G
authors: G
authors: Van Assche
authors: Inflammatory Bowel Disease Center, Department of Gastroenterology, Humanitas Research Hospital, Rozzano, Milan, Italy.
authors: S
authors: S
authors: Danese
authors: Department of Gastroenterology, Hospital Clinic of Barcelona, IDIBAPS, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
authors: J
authors: J
authors: Panes
authors: Service des Maladies de l'Appareil Digestif et INSERM U991, CHU Pontchaillou et Université de Rennes 1, Rennes, France.
authors: G
authors: G
authors: Bouguen
authors: Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
authors: S
authors: S
authors: O'Donnell
authors: Department of Hepato-Gastroenterology, Claude Huriez Hospital, Université Lille Nord de France, Lille, France.
authors: B
authors: B
authors: Pariente
authors: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
authors: S
authors: S
authors: Winer
authors: Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
authors: S
authors: S
authors: Hanauer
authors: Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors: J-F
authors: JF
authors: Colombel
mesh_terms: D019468:Disease Management; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000628:therapy*; D017410:Practice Guidelines as Topic; D012074:Remission Induction / Q000379:methods