title: BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".
abstract: Fried et al. (Reports, 19 December 2014, p. 1510) demonstrate electric field-dependent acceleration of biological catalysis using ketosteroid isomerase as a prototypic example. These findings were not extended to aqueous solution because water by itself has field fluctuations that are too large and fast to provide a catalytic effect. Given physiological context, when water electrostatic interactions are considered, electric fields play a less important role in the catalysis.
authors: Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Jiangxi 341000, China.
authors: Deliang
authors: D
authors: Chen
authors: Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. Department of Pathology, Texas Children's Hospital, Houston, TX 77030, USA. tor.savidge@bcm.edu.
authors: Tor
authors: T
authors: Savidge
mesh_terms: D007664:Ketosteroids / Q000378:metabolism*; D055672:Static Electricity; D013251:Steroid Isomerases / Q000737:chemistry*
chemical_list: D007664:Ketosteroids; D013251:Steroid Isomerases