title: [Allergic bronchopulmonary aspergillosis: a report of four cases with literature review].
abstract: OBJECTIVE
  To understand the clinical characteristics of allergic bronchopulmonary aspergillosis (ABPA) so as to diagnose and treat the disease earlier.
  
  
  METHODS
  A retrospective study was conducted on ABPA patients diagnosed in the Second Department of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University from April 2010 to March 2014. The literature of children's ABPA retrieved from the databases at home and abroad in recent 10 years were analyzed.
  
  
  RESULTS
  (1) Among the 4 cases of ABPA, cystic fibrosis (CF) and asthma were diagnosed in 2 and 1 cases, respectively. Cough was present in 3 patients, recurrent wheezing in 2 and chest tightness in 1 case. CT scans showed central bronchiectasis in all 4 cases, while 1 patient had migratory shadows. All cases had elevated serum total IgE, immediate cutaneous reaction to aspergillus fumigatus; A. fumigatus-specific IgE and IgG were positive in 4 cases. The diagnosis of the 4 cases was confirmed according to the history, radiologic investigations and laboratory findings. All of them were improved after the treatment with glucocorticosteroid and antifungal agents (voriconazole or itraconazole). (2) We retrieved articles on the ABPA in the databases at home and abroad published in the recent 10 years, there were 22 foreign reports and only one case in domestic report. Among the 22 foreign cases, 16 patients were CF, 3 were asthmatics. ABPA was diagnosed as the initial presentation in only one case with CF.
  
  
  CONCLUSIONS
  In asthmatics or the patients with allergic disease, if there are highly elevated serum total IgE, central bronchiectasis or recurrent atelectasis in chest imaging, the patients should be further investigated for ABPA. The diagnosed cases of ABPA should be screened for CF routinely.
authors: the Second Department of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
authors: Hui
authors: H
authors: Xu
authors: the Second Department of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
authors: Yuhong
authors: Y
authors: Zhao
authors: the Second Department of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
authors: Wei
authors: W
authors: Wang
authors: the Second Department of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
authors: Jinrong
authors: J
authors: Liu
authors: the Second Department of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China; Email: zhaoshunying2001@163.com.
authors: Shunying
authors: S
authors: Zhao
mesh_terms: D000935:Antifungal Agents; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis* / Q000628:therapy*; D001232:Aspergillus fumigatus; D001249:Asthma; D001987:Bronchiectasis; D002648:Child; D003371:Cough; D003550:Cystic Fibrosis; D006801:Humans; D001261:Pulmonary Atelectasis; D012189:Retrospective Studies; D013909:Thorax; D014057:Tomography, X-Ray Computed; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole