title: Renal LECT2 amyloidosis: a newly described disorder gaining greater recognition.
abstract: Amyloidosis results from the pathologic deposition of beta pleated sheet fibrils within various organs including the kidney. Most often, the deposition is composed of the well-known monoclonal immunoglobulin light chains (AL) or serum amyloid A protein (AA). Recently, a new type of amyloidogenic protein was discovered, leukocyte chemotactic factor 2 (LECT2). This type of amyloid tends to have an affinity to kidney and liver and is recognized as a distinct clinico-pathologic type of amyloidosis, presenting with varying degrees of impaired kidney function and proteinuria. Herein, a case of this uncommon novel amyloidosis is presented with a brief review of the literature.
authors: Andrew
authors: A
authors: Kowalski
authors: Julio
authors: J
authors: Cabrera
authors: Samih
authors: S
authors: Nasr
authors: Edgar
authors: E
authors: Lerma
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C103468:LECT2 protein, human