title: Catheter ablation for atrial fibrillation in hypertrophic cardiomyopathy patients: a systematic review.
abstract: OBJECTIVE
  The primary aim of this systematic review was to assess the efficacy of catheter ablation of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM). Differentiation based off catheter ablation modalities was not considered due to the limited scope of the current field. Studies that employed alcohol septal ablation for the treatment of AF in HCM patients were excluded as were abstracts, case reports, conference presentations, editorials, reviews, and expert opinions
  
  
  METHODS
  Electronic searches were performed in six databases from their inception until January 2014. Relevant studies regarding catheter ablation for AF in HCM populations were identified. Data was extracted and analyzed according to pre-defined clinical endpoints
  
  
  RESULTS
  A review was undertaken of eight studies in which 241 HCM patients underwent catheter ablation for AF. Overall AF-free survival at last follow-up ranged from 47 to 77% (64-67%). Sinus rhythm was maintained at last follow-up in 47-82% (median 64-67%). AF recurrence ranged from 0 to 66% (median 35-40%).
  
  
  CONCLUSIONS
  A review of the current evidence suggests that catheter ablation of AF in HCM patients is effective with suitable efficacy and is justified in select patients. Future adequately powered randomized studies should be undertaken aimed at addressing long-term efficacy and complications associated with procedural outcomes.
authors: Faculty of Medicine, University of New South Wales (UNSW), Sydney, Australia.
authors: Hakeem S K
authors: HS
authors: Ha
authors: Faculty of Medicine, University of Sydney, Sydney, Australia.
authors: Nelson
authors: N
authors: Wang
authors: Faculty of Medicine, University of New South Wales (UNSW), Sydney, Australia.
authors: Sophia
authors: S
authors: Wong
authors: Faculty of Medicine, University of Sydney, Sydney, Australia.
authors: Steven
authors: S
authors: Phan
authors: Faculty of Medicine, University of Sydney, Sydney, Australia.
authors: Jace
authors: J
authors: Liao
authors: Department of Cardiology, Maastrict University Medical Center, Maastricht, The Netherlands.
authors: Narendra
authors: N
authors: Kumar
authors: Faculty of Medicine, University of Sydney, Sydney, Australia.|Department of Cardiology, Westmead Hospital, Sydney, Australia.
authors: Pierre
authors: P
authors: Qian
authors: Faculty of Medicine, University of Sydney, Sydney, Australia.|The Collaborative Research (CORE) Group, Macquarie University, 2 Technology Place, Sydney, 2109, Australia.
authors: Tristan D
authors: TD
authors: Yan
authors: Faculty of Medicine, University of New South Wales (UNSW), Sydney, Australia. kphan.vc@gmail.com.|Faculty of Medicine, University of Sydney, Sydney, Australia. kphan.vc@gmail.com.|Department of Cardiology, Westmead Hospital, Sydney, Australia. kphan.vc@gmail.com.|The Collaborative Research (CORE) Group, Macquarie University, 2 Technology Place, Sydney, 2109, Australia. kphan.vc@gmail.com.
authors: Kevin
authors: K
authors: Phan
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D017115:Catheter Ablation / Q000401:mortality*; D015897:Comorbidity; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000401:mortality*; D015995:Prevalence; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Atrial fibrillation; Catheter ablation; Hypertrophic cardiomyopathy; Systematic review