title: Nasal septal perforation associated with pyoderma gangrenosum.
abstract: BACKGROUND
  Pyoderma gangrenosum (PG) is a skin condition characterized by necrotic ulcers and most commonly occurs on the legs in association with inflammatory bowel disease and rheumatoid arthritis; however, PG rarely involves the head and neck, and very rarely causes nasal septal perforation.
  
  
  OBJECTIVE
  Here, we describe a case report of PG causing nasal septal perforation in a 71-year-old male with truncal lesions in the absence of either inflammatory bowel disease or autoimmune arthritis.
  
  
  METHODS
  Case report with histologic description.
  
  
  RESULTS
  Histology from nasal mucosal biopsies showed chronic inflammation and reactive change without evidence of malignancy. Together with serologic and nonserologic testing, as well as clinical evaluation, we were able to rule out other causes of septal perforation including Wegener's granulomatosis, lymphoma, and vasculitis, and concluded that the cause of nasal septal perforation was most likely PG.
  
  
  CONCLUSIONS
  Septal perforation etiology should include a complete history and physical to evaluate for systemic etiologies, including rare ones such as PG.
authors: Department of Otolaryngology, University of Colorado, Aurora, Colorado, USA.
authors: Brook
authors: B
authors: McConnell
authors: M Sherif
authors: MS
authors: Said
authors: Vijay R
authors: VR
authors: Ramakrishnan