title: Active Targeting of Nano-Photosensitizer Delivery Systems for Photodynamic Therapy of Cancer Stem Cells.
abstract: Cancer stem cells are believed to be the basis for tumor initiation, development, metastasis and recurrence; are resistant to most traditional therapies (e.g., chemotherapy and radiotherapy); and have the ability to self-renew, proliferate and differentiate. Photodynamic therapy may be a promising novel treatment for drug-resistant cancer stem cells because of the selectivity of the photosensitizer. One of the most important issues to overcome in photodynamic therapy is the photosensitizer-targeted delivery to tumor cells, especially cancer stem cells. Nano-photosensitizers comprising molecular photosensitizers and water-dispersible nanocarriers with or without moieties possessing the ability for specific binding to cancer cells or cancer stem cells are a promising strategy for active targeted photosensitizer delivery and photodynamic therapy-targeted therapy of tumors. In this review, we highlight current and future prospects for potential strategies based on nanoscience and nanotechnology for nano-photosensitizer-targeted delivery in the photodynamic therapy treatment of cancer cells, especially cancer stem cells.
authors: Liangwu
authors: L
authors: Lin
authors: Li
authors: L
authors: Xiong
authors: Yu
authors: Y
authors: Wen
authors: Sanlin
authors: S
authors: Lei
authors: Xiaofeng
authors: X
authors: Deng
authors: Zhipeng
authors: Z
authors: Liu
authors: Wei
authors: W
authors: Chen
authors: Xiongying
authors: X
authors: Miao
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D010778:Photochemotherapy / Q000295:instrumentation / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D012008:Recurrence
chemical_list: D017319:Photosensitizing Agents