title: Quantitative Dobutamine Stress Echocardiography Using Speckle-Tracking Analysis versus Conventional Visual Analysis for Detection of Significant Coronary Artery Disease after ST-Segment Elevation Myocardial Infarction.
abstract: BACKGROUND
  Residual ischemia detection after ST-segment elevation myocardial infarction (STEMI) during dobutamine stress echocardiography (DSE) using visual analysis is challenging. The aim of the present study was to investigate the feasibility and accuracy of two-dimensional speckle-tracking strain DSE to detect significant coronary artery disease (CAD) after STEMI.
  
  
  METHODS
  First STEMI patients (n = 105; mean age, 60 ± 11 years; 86% men) treated with primary percutaneous coronary intervention undergoing full-protocol DSE at 3 months and repeat coronary angiography within 1 year were retrospectively included. Using two-dimensional speckle-tracking echocardiography, segmental and global left ventricular peak longitudinal systolic strain (PLSS) at rest and peak stress and change (Δ) in PLSS were measured. Significant CAD was defined as detection of >70% diameter stenosis at coronary angiography.
  
  
  RESULTS
  In total, 1,653 (93%) and 1,645 (92%) segments were analyzable at rest and peak stress, respectively. At follow-up, 38 patients (36%) showed significant angiographic CAD. These patients demonstrated greater worsening in global PLSS from rest to peak (-16.8 ± 0.5% to -12.6 ± 0.5%) compared with patients without significant CAD (-16.6 ± 0.4% to -14.3 ± 0.3%; group-stage interaction P < .001). The optimal cutoff of ΔPLSS for the detection of significant CAD on receiver operating characteristic curve analysis was ≥1.9% (area under the curve, 0.70; sensitivity, 87%; specificity, 46%; accuracy, 60%). Using a sentinel segment approach (apex, midposterior, and midinferior for the left anterior descending, left circumflex, and right coronary artery territories, respectively), larger segmental ΔPLSS was also independently associated with significant CAD (odds ratio, 1.1; 95% CI, 1.1-1.2).
  
  
  CONCLUSIONS
  Two-dimensional speckle-tracking echocardiographic strain analysis is feasible on DSE after STEMI and represents a promising new technique to detect significant angiographic CAD at follow-up.
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Emer
authors: E
authors: Joyce
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Georgette E
authors: GE
authors: Hoogslag
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Ibithal
authors: I
authors: Al Amri
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Philippe
authors: P
authors: Debonnaire
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Spyridon
authors: S
authors: Katsanos
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Jeroen J
authors: JJ
authors: Bax
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Victoria
authors: V
authors: Delgado
authors: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: n.ajmone@lumc.nl.
authors: Nina Ajmone
authors: NA
authors: Marsan
mesh_terms: D002316:Cardiotonic Agents / Q000494:pharmacology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D004280:Dobutamine / Q000494:pharmacology*; D025401:Echocardiography, Stress / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology; D013997:Time Factors
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine
keywords: Coronary angiography; Dobutamine stress echocardiography; ST-segment elevation myocardial infarction; Two-dimensional strain