title: Biotransformation of anthocyanins from two purple-fleshed sweet potato accessions in a dynamic gastrointestinal system.
abstract: Cooked, milled purple-fleshed sweet potato (PFSP) accessions, PM09.812 and PM09.960, underwent digestion in a dynamic human gastrointestinal (GI) model that simulates gut digestive conditions to study the bioaccessibility and biotransformation of anthocyanins. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry showed accession-dependent variations in anthocyanin release and degradation. After 24h, more anthocyanin species were detected in the small intestinal vessel relative to other vessels for accession PM09.960 whereas more species appeared in the ascending colonic vessel for accession PM09.812. The ferric reducing antioxidant power was increased in the small intestinal vessel for PM09.960 and in the ascending colonic vessel for accession PM09.812, corresponding to the appearance of a majority of anthocyanins for each accession. These results show that intestinal and colonic microbial digestion of PFSP leads to an accession-dependent pattern for anthocyanin bioaccessibility and degradation.
authors: School of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore, Ste. Anne de Bellevue, QC H9X 3V9, Canada. Electronic address: stan.kubow@mcgill.ca.
authors: Stan
authors: S
authors: Kubow
authors: School of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore, Ste. Anne de Bellevue, QC H9X 3V9, Canada. Electronic address: michele.iskandar@mail.mcgill.ca.
authors: Michèle M
authors: MM
authors: Iskandar
authors: School of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore, Ste. Anne de Bellevue, QC H9X 3V9, Canada. Electronic address: kebba.sabally@mcgill.ca.
authors: Kebba
authors: K
authors: Sabally
authors: School of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore, Ste. Anne de Bellevue, QC H9X 3V9, Canada. Electronic address: behnam.azadi@mcgill.ca.
authors: Behnam
authors: B
authors: Azadi
authors: School of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore, Ste. Anne de Bellevue, QC H9X 3V9, Canada. Electronic address: shima.sadeghi@mail.mcgill.ca.
authors: Shima
authors: S
authors: Sadeghi Ekbatan
authors: Analytical Biochemistry and Proteomics Laboratory, Mechanistic Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Drwy, Ottawa, ON K1A 0K9, Canada. Electronic address: premkumari.kumarathasan@hc-sc.gc.ca.
authors: Premkumari
authors: P
authors: Kumarathasan
authors: Analytical Biochemistry and Proteomics Laboratory, Mechanistic Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Drwy, Ottawa, ON K1A 0K9, Canada. Electronic address: dharani.das@hc-sc.gc.ca.
authors: Dharani Dhar
authors: DD
authors: Das
authors: BioMedical Engineering Department, McGill University, 3775 University Street, Room 311, Montreal, QC H3A 2B4, Canada. Electronic address: satya.prakash@mcgill.ca.
authors: Satya
authors: S
authors: Prakash
authors: International Potato Center (CIP), Avenida La Molina 1895, La Molina, Apartado Postal 1558 Lima, Peru. Electronic address: g.burgos@cgiar.org.
authors: Gabriela
authors: G
authors: Burgos
authors: International Potato Center (CIP), Avenida La Molina 1895, La Molina, Apartado Postal 1558 Lima, Peru. Electronic address: t.zumfelde@cgiar.org.
authors: Thomas
authors: T
authors: Zum Felde
mesh_terms: D000872:Anthocyanins / Q000032:analysis / Q000378:metabolism*; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D001711:Biotransformation; D003296:Cooking; D004063:Digestion / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000382:microbiology* / Q000502:physiology; D006801:Humans; D027723:Ipomoea batatas / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological
chemical_list: D000872:Anthocyanins; D000975:Antioxidants
keywords: Anthocyanins; Bioaccessibility; Biotransformation; Human gastro-intestinal model; Ipomoea batatas L.; Purple fleshed sweet potato