title: Exploring the role of interleukin-22 in neurological and autoimmune disorders.
abstract: Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that has recently gained attention in regard to its recognized pathogenic role in neurological and autoimmune disorders. The pathological involvement of IL-22 has been linked to Th17 cells that are involved in its production. Its biological activity results from its ability to bind to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. Emerging evidence has identified IL-22 involvement in neurological diseases and autoimmune disorders such as Guillain-Barré Syndrome (GBS), multiple sclerosis (MS), Alzheimer's disease (AD), encephalitis, inflammatory myopathies, myasthenia gravis (MG), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), psoriasis and Crohn's disease (CD). However, the biological activity of IL-22 is variable resulting in protective or pathogenic effects in different disease states. As such, the development of therapeutic targeting strategies to modify the biological activity of IL-22 is being explored as a promising interventional approach to treat neurological and autoimmune diseases.
authors: Department of Neurology, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province 215021, China.
authors: Ning
authors: N
authors: Xin
authors: College of Pharmacy and Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
authors: Michael Peter
authors: MP
authors: Namaka
authors: Department of Neurology, Shouguang People's Hospital, Shouguang, Shandong, China.
authors: Changxin
authors: C
authors: Dou
authors: Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China. Electronic address: zy2003njmu@163.com.
authors: Yong
authors: Y
authors: Zhang
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D016753:Interleukin-10 / Q000276:immunology; D053710:Interleukin-10 Receptor beta Subunit / Q000378:metabolism; D007378:Interleukins / Q000276:immunology*; D058990:Molecular Targeted Therapy; D009422:Nervous System Diseases / Q000276:immunology* / Q000628:therapy; D018123:Receptors, Interleukin / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology*; D000097043:Interleukin-22
chemical_list: D016753:Interleukin-10; D053710:Interleukin-10 Receptor beta Subunit; D007378:Interleukins; D018123:Receptors, Interleukin; D000097043:Interleukin-22; C081846:IL10RB protein, human; C415369:interleukin-22 receptor
keywords: Autoimmune diseases; Cytokines; IL-22; Interventional therapeutics; Neurological diseases; Th17