title: Subtype associations with HIV-associated neurocognitive disorder in China.
abstract: Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p < 0.01) and CD4(+) counts (p = 0.03). HAND was also associated with AIDS (p < 0.01), but subtype was not (p = 0.198). Furthermore, worse impairment correlated with higher viral diversity (r = 0.16, p < 0.01), lower nadir (r = -0.17, p < 0.01), and CD4(+) counts (r = -0.11, p = 0.01). These remained significant even when correcting for subtype. Our findings suggest that subtype does not have a major impact on HAND.
authors: University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA. tyler.day@outlook.com.
authors: Tyler R C
authors: TR
authors: Day
authors: University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA.|Veterans Administration San Diego Healthcare System, San Diego, CA, USA.
authors: Davey M
authors: DM
authors: Smith
authors: Veterans Administration San Diego Healthcare System, San Diego, CA, USA.
authors: Robert K
authors: RK
authors: Heaton
authors: Veterans Administration San Diego Healthcare System, San Diego, CA, USA.
authors: Donald
authors: D
authors: Franklin
authors: Veterans Administration San Diego Healthcare System, San Diego, CA, USA.
authors: Myers W
authors: MW
authors: Tilghman
authors: University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA.
authors: Scott
authors: S
authors: Letendre
authors: University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA.
authors: Hua
authors: H
authors: Jin
authors: Chinese Center for Disease Control and Prevention, Beijing, China.
authors: Zunyou
authors: Z
authors: Wu
authors: Institute of Mental Health, Peking University, Beijing, China.
authors: Chuan
authors: C
authors: Shi
authors: Institute of Mental Health, Peking University, Beijing, China.
authors: Xin
authors: X
authors: Yu
authors: University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA.
authors: Josué
authors: J
authors: Pérez-Santiago
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002681:China; D060825:Cognitive Dysfunction / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D015331:Cohort Studies; D056344:Executive Function; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012307:Risk Factors; D019562:Viral Load / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents
keywords: CD4 nadir; HIV subtype; HIV-associated; Neurocognitive disorders; Neurocognitive impairment