title: Heparin induced thrombocytopenia. Contemporary therapeutic approaches in light of the new oral anticoagulants.
abstract: Heparin induced thrombocytopenia (HIT) is a prothrombotic syndrome initiated by platelet-activating auto-antibodies with potentially devastating complications. Once the diagnosis of HIT is suspected, discontinuation of heparin and treatment with an alternative anticoagulant are mandatory. While established drugs for HIT are no longer available, parenteral factor Xa inhibitors, thrombin inhibitors and perhaps the direct oral anticoagulants provide additional treatment options. The aim of this review was to highlight the current clinical aspects regarding HIT focusing on the role of novel medications.
authors: Elias Sanidas MD, PhD, FACC, FESC, Department of Cardiology, Laiko General Hospital, 17 Agiou Thoma street, 11527, Athens, Greece, easanidas@yahoo.gr.
authors: E A
authors: EA
authors: Sanidas
authors: N A
authors: NA
authors: Viniou
authors: P
authors: P
authors: Diamantopoulos
authors: J
authors: J
authors: Barbetseas
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects*; D057915:Drug Substitution / Q000379:methods; D019317:Evidence-Based Medicine; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000517:prevention & control*; D013927:Thrombosis / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006493:Heparin
keywords: DOAC; HIT