title: [Dry eye syndrome in patients with primary open-angle glaucoma].
abstract: OBJECTIVE
  to determine the frequency and severity of dry eye syndrome (DES) in primary open-angle glaucoma (POAG) patients that are newly diagnosed or already receiving beta blocker instillation therapy.
  
  
  METHODS
  A total of 127 patients (190 eyes) with POAG were divided into two groups. Group 1 included 55 newly diagnosed patients (88 eyes), group 2-72 POAG patients (102 eyes) instilling timolol 0.5% twice daily into the affected eye. The control group included 20 patients (40 eyes) aged 60-88 years (73.6 ± 9.2 years on average) with early age-related cataract.
  
  
  RESULTS
  DES was found in 69 POAG patients (79%) who was just starting their topical hypotensive therapy and 85 of those (84%) under treatment (p = 0.39).
  
  
  CONCLUSIONS
  One should take into account when prescribing ocular hypotensive therapy that newly diagnosed POAG patients usually already suffer from a dry eye. The use of topical beta blockers that contain preservatives exacerbates dry eye signs and symptoms in these patients.
authors: Military Medical Academy named after S.M. Kirov, Ministry of Defense of the Russian Federation, 6 Akademika Lebedeva St., Saint-Petersburg, Russian Federation, 194044.
authors: E V
authors: EV
authors: Boyko
authors: Military Medical Academy named after S.M. Kirov, Ministry of Defense of the Russian Federation, 6 Akademika Lebedeva St., Saint-Petersburg, Russian Federation, 194044.
authors: I L
authors: IL
authors: Simakova
authors: Military Medical Academy named after S.M. Kirov, Ministry of Defense of the Russian Federation, 6 Akademika Lebedeva St., Saint-Petersburg, Russian Federation, 194044.
authors: D Yu
authors: DY
authors: Yakushev
authors: Ophthalmologic Clinical Hospital, Moscow Health Department, 7 Mamonovskiy pereulok, Moscow, Russian Federation, 123001.
authors: S A
authors: SA
authors: Ignat'ev
authors: Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, 2/1 Barrikadnaya St., Moscow, Russian Federation, 123995.
authors: I B
authors: IB
authors: Alekseev
authors: Ophthalmologic Clinical Hospital, Moscow Health Department, 7 Mamonovskiy pereulok, Moscow, Russian Federation, 123001.
authors: N V
authors: NV
authors: Mel'nikova
authors: Military Medical Academy named after S.M. Kirov, Ministry of Defense of the Russian Federation, 6 Akademika Lebedeva St., Saint-Petersburg, Russian Federation, 194044.
authors: M V
authors: MV
authors: Alyab'ev
authors: Military Medical Academy named after S.M. Kirov, Ministry of Defense of the Russian Federation, 6 Akademika Lebedeva St., Saint-Petersburg, Russian Federation, 194044.
authors: D S
authors: DS
authors: Mal'tsev
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D012426:Russia / Q000453:epidemiology