title: Formation of Tubulovesicular Carriers from Endosomes and Their Fusion to the trans-Golgi Network.
abstract: Endosomes undergo extensive spatiotemporal rearrangements as proteins and lipids flux through them in a series of fusion and fission events. These controlled changes enable the concentration of cargo for eventual degradation while ensuring the proper recycling of other components. A growing body of studies has now defined multiple recycling pathways from endosomes to the trans-Golgi network (TGN) which differ in their molecular machineries. The recycling process requires specific sets of lipids, coats, adaptors, and accessory proteins that coordinate cargo selection with membrane deformation and its association with the cytoskeleton. Specific tethering factors and SNARE (SNAP (Soluble NSF Attachment Protein) Receptor) complexes are then required for the docking and fusion with the acceptor membrane. Herein, we summarize some of the current knowledge of the machineries that govern the retrograde transport from endosomes to the TGN.
authors: Structural Biology Unit, CIC bioGUNE, Derio, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
authors: Aitor
authors: A
authors: Hierro
authors: Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors: David C
authors: DC
authors: Gershlick
authors: Structural Biology Unit, CIC bioGUNE, Derio, Spain.
authors: Adriana L
authors: AL
authors: Rojas
authors: Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors: Juan S
authors: JS
authors: Bonifacino
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D011992:Endosomes / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008561:Membrane Fusion / Q000502:physiology*; D050600:SNARE Proteins / Q000235:genetics / Q000378:metabolism*; D021601:trans-Golgi Network / Q000235:genetics / Q000378:metabolism*
chemical_list: D050600:SNARE Proteins
keywords: Endosomes; Membrane recycling; Membrane tethering; Retrograde transport; SNARE complexes; trans-Golgi network