title: High prevalence of hepatitis B virus infection in primary central nervous system lymphoma.
abstract: Primary central nervous system lymphoma (PCNSL) is a rare extranodal form of non-Hodgkin lymphoma (NHL). The present study aimed to investigate the potential association between infection with the Hepatitis B virus (HBV) and PCNSL. The prevalence of HBV infection in 199 patients with PCNSL was compared in our hospital with that of an age-and sex-matched group of patients with other cancers (except liver cancer), and with a national population-based control group. Enzyme-linked immunosorbent assays were used to test blood samples for HBV markers. It was found that the prevalence of HBV infection in PCNSL was 16.1%, which was higher as compared with patients with other non-hematologic cancers and the national population-based control group. In conclusion, the present study demonstrated that PCNSL patients had a higher prevalence of HBV infection and suggested a potential association between infection with HBV and PCNSL.
authors: Shanghai Blood Center Shanghai 200051, P. R. China.
authors: Yan
authors: Y
authors: Meng
authors: Department of Medical Oncology, Cancer Hospital, Minhang Branch, Fudan University Minhang District, Shanghai 200240, P. R. China.
authors: Shengli
authors: S
authors: He
authors: Department of Laboratory Medicine, Hua-Shan Hospital, Fudan University Shanghai 200040, P. R. China.
authors: Qin
authors: Q
authors: Liu
authors: Department of Laboratory Medicine, Hua-Shan Hospital, Fudan University Shanghai 200040, P. R. China.
authors: Dongwen
authors: D
authors: Xu
authors: Department of Laboratory Medicine, Hua-Shan Hospital, Fudan University Shanghai 200040, P. R. China.
authors: Tao
authors: T
authors: Zhang
authors: Department of Hematology, Hua-Shan Hospital, Fudan University Shanghai 200040, P. R. China.
authors: Zi
authors: Z
authors: Chen
keywords: Primary central nervous system lymphoma; hepatitis B virus infection; non-Hodgkin lymphoma