title: Prognostic value of SYNTAX score based on coronary computed tomography angiography.
abstract: BACKGROUND
  The long-term prognostic value of the computed tomography (CT)-based SYNTAX score has not yet been investigated. The aim of our study was to investigate the prognostic value of the CT-SYNTAX score in predicting major adverse cardiac events (MACEs) in populations who underwent both coronary computed tomography (CCTA) and invasive coronary angiography (ICA), compared with prognostic values of coronary artery disease (CAD) findings on CCTA and the ICA-based SYNTAX score.
  
  
  METHODS
  We retrospectively included 339 patients (213 men, mean age of 63.8±9.45years) with suspected CAD who underwent CCTA and ICA. SYNTAX score was obtained based on both CCTA and ICA. Follow-up clinical outcome data regarding composite MACEs were obtained. Cox proportional hazard models were developed to predict MACEs based on clinical variables, number of CAD vessels, and SYNTAX scores based on CCTA and ICA. The time-dependent receiver operating characteristic curve method was used, and the integrated area under the curve (iAUC) was calculated to compare the predictive prognosis of the models.
  
  
  RESULTS
  During the median follow-up of 1374days, there were 30 MACEs. In multivariate Cox regression adjusted for clinical variables, SYNTAX score group 4 (≥33) on CCTA and SYNTAX score groups 3 (23-32) and 4 (≥33) on ICA showed increased hazard ratios for MACEs compared to SYNTAX score group 1 (0). CT-SYNTAX score demonstrated no significant difference in iAUC compared with ICA-SYNTAX score and the number of vessels of CAD on CCTA.
  
  
  CONCLUSIONS
  CT-SYNTAX score can be a useful method for non-invasively predicting MACEs, especially in patients with complex CAD.
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Young Joo
authors: YJ
authors: Suh
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Yoo Jin
authors: YJ
authors: Hong
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Hye-Jeong
authors: HJ
authors: Lee
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Jin
authors: J
authors: Hur
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Young Jin
authors: YJ
authors: Kim
authors: Biostatistics Collaboration Unit, Medical Research Center, South Korea.
authors: Hye Sun
authors: HS
authors: Lee
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Sae Rom
authors: SR
authors: Hong
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Dong Jin
authors: DJ
authors: Im
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Yun Jung
authors: YJ
authors: Kim
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Chul Hwan
authors: CH
authors: Park
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Tae Hoon
authors: TH
authors: Kim
authors: Department of Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, South Korea.
authors: Kyung-Jong
authors: KJ
authors: Yoo
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, South Korea. Electronic address: bchoi@yuhs.ac.
authors: Byoung Wook
authors: BW
authors: Choi
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000008:administration & dosage; D000368:Aged; D017023:Coronary Angiography / Q000009:adverse effects / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D014665:Vasodilator Agents; D005996:Nitroglycerin; D008790:Metoprolol
keywords: Coronary computed tomography angiography; Prognosis; SYNTAX score