title: Proteomics of the Synapse--A Quantitative Approach to Neuronal Plasticity.
abstract: The advances in mass spectrometry based proteomics in the past 15 years have contributed to a deeper appreciation of protein networks and the composition of functional synaptic protein complexes. However, research on protein dynamics underlying core mechanisms of synaptic plasticity in brain lag far behind. In this review, we provide a synopsis on proteomic research addressing various aspects of synaptic function. We discuss the major topics in the study of protein dynamics of the chemical synapse and the limitations of current methodology. We highlight recent developments and the future importance of multidimensional proteomics and metabolic labeling. Finally, emphasis is given on the conceptual framework of modern proteomics and its current shortcomings in the quest to gain a deeper understanding of synaptic plasticity.
authors: From the ‡Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Germany; Research Group Neuralomics, Leibniz Institute for Neurobiology Magdeburg, Germany; ¶Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany. kreutz@lin-magdeburg.de daniela.dieterich@med.ovgu.de.
authors: Daniela C
authors: DC
authors: Dieterich
authors: §RG Neuroplasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany; ¶Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany. kreutz@lin-magdeburg.de daniela.dieterich@med.ovgu.de.
authors: Michael R
authors: MR
authors: Kreutz
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D009473:Neuronal Plasticity / Q000235:genetics*; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D013569:Synapses / Q000235:genetics* / Q000378:metabolism
chemical_list: D011506:Proteins