title: Comparative analysis of methods for real-time analytical control of chemotherapies preparations.
abstract: Control of chemotherapies preparations are now an obligation in France, though analytical control is compulsory. Several methods are available and none of them is presumed as ideal. We wanted to compare them so as to determine which one could be the best choice. We compared non analytical (visual and video-assisted, gravimetric) and analytical (HPLC/FIA, UV/FT-IR, UV/Raman, Raman) methods thanks to our experience and a SWOT analysis. The results of the analysis show great differences between the techniques, but as expected none us them is without defects. However they can probably be used in synergy. Overall for the pharmacist willing to get involved, the implementation of the control for chemotherapies preparations must be widely anticipated, with the listing of every parameter, and remains according to us an analyst's job.
authors: Pharmacy, CHU Angers, 9 rue Larrey, 49933 Angers Cedex 9, France. Electronic address: dr.bazin@gmail.com.
authors: Christophe
authors: C
authors: Bazin
authors: Pharmacy, Centre Hospitalier Marc Jacquet, 2 rue Fréteau de Peny, 77011 Melun Cedex, France.
authors: Bruno
authors: B
authors: Cassard
authors: Pharmacy, Hôpital Européen Georges-Pompidou, 20 rue Leblanc, 75908 Paris Cedex 15, France.
authors: Eric
authors: E
authors: Caudron
authors: Pharmacy, Hôpital Européen Georges-Pompidou, 20 rue Leblanc, 75908 Paris Cedex 15, France.
authors: Patrice
authors: P
authors: Prognon
authors: Pharmacy, Hôpital Européen Georges-Pompidou, 20 rue Leblanc, 75908 Paris Cedex 15, France.
authors: Laurent
authors: L
authors: Havard
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis*; D002623:Chemistry Techniques, Analytical / Q000191:economics* / Q000592:standards*; D002851:Chromatography, High Pressure Liquid; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D014741:Video Recording; D014894:Weights and Measures / Q000592:standards
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapies; Control; FIA; HPLC; Raman; UV/IR