title: The Diagnostic Value of Oxidative/Antioxidative Balance Parameters in Venous Thromboembolism.
abstract: BACKGROUND
  The aim of this study is to observe the association between venous thromboembolism (VTE) and oxidative stress and to see if there is a diagnostic value in the oxidative/antioxidative balance parameters like total oxidant status (TOS), total antioxidant status (TAS), paraoxonase-(PON1), and arylesterase (ARE) enzyme activities in this specific disease.
  
  
  METHODS
  Sixty-nine patients with deep vein thrombosis and/or pulmonary embolism and 40 control subjects were included in the study. Oxidative stress index, total oxidant status, and antioxidant status were examined in addition to the PON1 and ARE enzyme activities in both groups.
  
  
  RESULTS
  Serum PON1 and ARE activities were significantly lower in the VTE patients, whereas total oxidant status was higher in patients compared to the controls.
  
  
  CONCLUSIONS
  This preliminary study showed that oxidative/antioxidative balance shifted towards the oxidative status in venous thromboembolism. ROC analysis results suggested that the parameters used in this study were not good enough to be used in the diagnosis of VTE.
authors: Gizin
authors: G
authors: Aykal
authors: Ramazan
authors: R
authors: Güven
authors: Ayşenur
authors: A
authors: Yeğin
authors: Hamit Yaşar
authors: HY
authors: Ellidağ
authors: Asli
authors: A
authors: Bayindir
authors: Necat
authors: N
authors: Yilmaz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D019540:Area Under Curve; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000097:blood / Q000175:diagnosis*; D012372:ROC Curve; D054556:Venous Thromboembolism / Q000097:blood / Q000175:diagnosis*; D020246:Venous Thrombosis / Q000097:blood / Q000175:diagnosis*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human