title: Outcome measurement in neurodegenerative disease: attributes, applications & interpretation.
abstract: There has been a marked shift from clinically assessed to patient assessed outcomes of treatment in neurodegenerative conditions over recent decades. The use of patient-reported outcome measures (PROMs) provides a method with which researchers and clinicians can gain insightful and meaningful data on health status from the patients' perspective. It is imperative that high-quality PROMs are chosen based upon their measurement properties and their suitability for use in the intended clinical or research context. This review aims to give a brief overview of best practice standards for selecting PROMs, current instruments used in exemplar neurodegenerative conditions and their application in clinical trials and routine measurement.
authors: Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.
authors: Laura
authors: L
authors: Kelly
authors: Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.
authors: Crispin
authors: C
authors: Jenkinson
authors: Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.
authors: David
authors: D
authors: Morley
mesh_terms: D006304:Health Status; D006801:Humans; D019636:Neurodegenerative Diseases / Q000175:diagnosis*; D063868:Patient Outcome Assessment; D011788:Quality of Life; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires
keywords: clinical trial; disease specific; generic; neurodegenerative outcomes; patient-reported outcome measure; questionnaire; reliability; responsiveness; validity