title: Serum Syndecan-1 Levels and Its Relationship to Disease Activity in Patients with Crohn's Disease.
abstract: Background. Syndecan-1 (SDC-1), a member of the family of heparan sulfate proteoglycans, plays an important role in the resolution of inflammation. This study aimed to investigate the relationship between SDC-1 and disease activity in Crohn's disease (CD). Methods. Serum samples of 54 patients with CD and 30 healthy controls were obtained. First, SDC-1 levels of the CD patients were compared to the control group. Subsequently, SDC-1 levels were analyzed in patients with CD in active and remission periods. Finally, SDC-1 efficacy in predicting disease activity was evaluated by performing correlation analysis between SDC-1 and C-reactive protein (CRP) and Crohn's disease activity index (CDAI). Results. SDC-1 level was higher in the CD group (61.9 ± 42.6 ng/mL) compared with the control group (34.1 ± 8.0 ng/mL) (p = 0.03). SDC-1 levels were higher in active CD patients (97.1 ± 40.3 ng/mL) compared with those in remission (33.7 ± 13.5 ng/mL) (p < 0.001). A significant positive correlation was found between SDC-1 and CRP (r = 0.687, p < 0.001) and between SDC-1 and CDAI (r = 0.747, p < 0.001). Conclusion. Serum levels of SDC-1 are higher in CD compared to the normal population and can be an effective marker of disease severity.
authors: Department of Gastroenterology, Katip Çelebi University, Atatürk Training and Research Hospital, 35360 İzmir, Turkey.
authors: Cem
authors: C
authors: Çekiç
authors: Department of Gastroenterology, Faculty of Medicine, Şifa University, 35100 İzmir, Turkey.
authors: Adnan
authors: A
authors: Kırcı
authors: Department of Gastroenterology, Katip Çelebi University, Atatürk Training and Research Hospital, 35360 İzmir, Turkey.
authors: Sezgin
authors: S
authors: Vatansever
authors: Department of Gastroenterology, Katip Çelebi University, Atatürk Training and Research Hospital, 35360 İzmir, Turkey.
authors: Fatih
authors: F
authors: Aslan
authors: Department of Biochemistry, Katip Çelebi University, Atatürk Training and Research Hospital, 35360 İzmir, Turkey.
authors: Huriye Erbak
authors: HE
authors: Yılmaz
authors: Department of Gastroenterology, Katip Çelebi University, Atatürk Training and Research Hospital, 35360 İzmir, Turkey.
authors: Emrah
authors: E
authors: Alper
authors: Department of Gastroenterology, Katip Çelebi University, Atatürk Training and Research Hospital, 35360 İzmir, Turkey.
authors: Mahmut
authors: M
authors: Arabul
authors: Department of Gastroenterology, Katip Çelebi University, Atatürk Training and Research Hospital, 35360 İzmir, Turkey.
authors: Elif
authors: E
authors: Sarıtaş Yüksel
authors: Department of Gastroenterology, Katip Çelebi University, Atatürk Training and Research Hospital, 35360 İzmir, Turkey.
authors: Belkıs
authors: B
authors: Ünsal