title: Life-threatening bradyarrhythmia with oral phenytoin overdose.
abstract: We report a case of a 41-year-old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a temporary transvenous pacer for her hemodynamic instability. This life-threatening cardiotoxicity of phenytoin could have been due to its interaction with sulphonylurea. It is imperative to be aware of drug interactions, due to which, life-threatening cardiovascular manifestations following phenytoin toxicity can occur.
authors: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: Giridharan
authors: G
authors: Srinivasan
authors: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: Mukta
authors: M
authors: Wyawahare
authors: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: Pratheesh George
authors: PG
authors: Mathen
authors: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: Dharanipragada K
authors: DK
authors: Subrahmanyam
keywords: Cardiotoxicity; glibenclamide; sulphonylurea