title: [Impacts of antiretroviral treatment on drug use and high risk sexual behaviors among HIV-positive MMT clients].
abstract: OBJECTIVE
  To explore the impacts of antiretroviral treatment on drug use and high risk sexual behaviors among HIV-positive MMT clients.
  
  
  METHODS
  A cross-sectional study was conducted in patients undergoing ART (ART-experienced) and patients not undergoing ART (ART-naive) attending MMT in 5 clinics in Yunnan Honghe and Dehong prefectures in 2014. A questionnaire was designed to collect socio-demographic characteristics, ART and MMT information and sexual and drug use behaviors within 3 months before the investigation was conducted. Logistic regression analysis was conducted to identify the predictors for drug use and risky sexual behaviors.
  
  
  RESULTS
  A total of 328 cases were included in the analysis, among which 202 were ART-experienced and 126 were ART-naÏve. Among 152 respondents who were sexually active, 61 (40.1%) reported having unprotected sex (UPS) with their regular partners in the prior 3 months. A total of 57.6% (189/328) of the respondents used drugs in the prior 3 months. Multiple logistic regression analysis revealed that younger than 35 years old (OR = 3.57, 95% CI: 1.23-10.37), fertility desire (OR = 4.47, 95% CI: 1.49-13.41), partner being HIV-positive (OR = 4.62, 95% CI: 1.80-11.86), length of MMT attendance less than 5 years (OR = 2.92, 95% CI: 1.14-7.53), agreed that it was necessary to use condom no matter the viral load is high or low (OR = 0.14, 95% CI: 0.04-0.51) were protective factors of UPS in the prior 3 months. Multiple logistic regression analysis revealed that being Han (OR = 0.46, 95% CI: 0.24-0.89), feeling having good health status (OR = 0.39, 95% CI: 0.18-0.85), being enrolled in ART (OR = 0.32, 95% CI: 0.17-0.60) were protective factors for drug use in the prior three months, having contact with drug using friends (OR = 4.41, 95% CI: 2.31-8.29), having experience of missing an MMT dose (OR = 3.47, 95% CI: 1.92-6.29), and not satisfied with current MMT dose (OR = 13.92, 95% CI: 3.24-59.93) were risk factors for drug use during the prior three months.
  
  
  CONCLUSIONS
  ART was not associated with risky sexual behavior and drug use in the prior 3 months in this population. Future interventions should promote ART among this population, and provide education at the same time to prevent the emergence of cross infections and drug-resistant strains.
authors: School of Public Health, Anhui Medical University, Hefei 230032, China.
authors: Xiaoai
authors: X
authors: Qian
authors: Xiaobin
authors: X
authors: Cao
authors: Yan
authors: Y
authors: Zhao
authors: Changhe
authors: C
authors: Wang
authors: Wei
authors: W
authors: Luo
authors: Keming
authors: K
authors: Rou
authors: Bo
authors: B
authors: Zhang
authors: Xiangdong
authors: X
authors: Min
authors: Song
authors: S
authors: Duan
authors: Renhai
authors: R
authors: Tang
authors: Email: wuzy@263.net.
authors: Zunyou
authors: Z
authors: Wu
mesh_terms: D006801:Humans; D019380:Anti-HIV Agents; D002681:China; D017280:Condoms; D003430:Cross-Sectional Studies; D015658:HIV Infections; D006679:HIV Seropositivity; D065840:Protective Factors; D012307:Risk Factors; D012309:Risk-Taking; D012725:Sexual Behavior; D012747:Sexual Partners; D019966:Substance-Related Disorders; D047568:Unsafe Sex; D008691:Methadone
chemical_list: D019380:Anti-HIV Agents; D008691:Methadone