title: EGFR signaling in renal fibrosis.
abstract: Signaling through the epidermal growth factor receptor (EGFR) is involved in regulation of multiple biological processes, including proliferation, metabolism, differentiation, and survival. Owing to its aberrant expression in a variety of malignant tumors, EGFR has been recognized as a target in anticancer therapy. Increasingly, evidence from animal studies indicates that EGFR signaling is also implicated in the development and progression of renal fibrosis. The therapeutic value of EGFR inhibition has not yet been evaluated in human kidney disease. In this article, we summarize recent research into the role of EGFR signaling in renal fibrogenesis, discuss the mechanism by which EGFR regulates this process, and consider the potential of EGFR as an antifibrotic target.
authors: Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine , Shanghai, China ; Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University , Providence, Rhode Island, USA.
authors: Shougang
authors: S
authors: Zhuang
authors: Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine , Shanghai, China.
authors: Na
authors: N
authors: Liu
keywords: EGFR; fibrosis; kidney; renal epithelial cells; transforming growth factor-β1