title: Post-radiotherapy hypothyroidism in dogs treated for thyroid carcinomas.
abstract: Hypothyroidism is a common adverse event after head and neck radiotherapy in human medicine, but uncommonly reported in canine patients. Records of 21 dogs with histologically or cytologically confirmed thyroid carcinoma receiving definitive or hypofractionated radiotherapy were reviewed. Nine cases received 48 Gy in 12 fractions, 10 received 36 Gy in 4 fractions and 2 received 32 Gy in 4 fractions. Seventeen cases had radiotherapy in a post-operative setting. Ten cases developed hypothyroidism (47.6%) after radiotherapy. The development of hypothyroidism was not associated with the radiotherapy protocol used. Median time to diagnosis of hypothyroidism was 6 months (range, 1-13 months). Hypothyroidism is a common side effect following radiotherapy for thyroid carcinomas. Monitoring of thyroid function following radiotherapy is recommended. No specific risk factors have been identified.
authors: Small Animal Teaching Hospital, University of Liverpool, Neston, Wirral, UK.
authors: I
authors: http://orcid.org/0000-0003-3645-1914
authors: I
authors: Amores-Fuster
authors: Veterinary Clinical Science, University of Liverpool, Neston, Wirral, UK.
authors: P
authors: P
authors: Cripps
authors: Small Animal Teaching Hospital, University of Liverpool, Neston, Wirral, UK.
authors: L
authors: L
authors: Blackwood
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000532:radiotherapy*; D004285:Dogs; D004739:England; D005260:Female; D007037:Hypothyroidism / Q000209:etiology / Q000662:veterinary*; D008297:Male; D000069473:Radiation Dose Hypofractionation; D011878:Radiotherapy / Q000009:adverse effects / Q000662:veterinary*; D012582:Schools, Veterinary; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000662:veterinary*; D014057:Tomography, X-Ray Computed / Q000662:veterinary
chemical_list: D000970:Antineoplastic Agents
keywords: dog; hypothyroidism; radiotherapy; side effect; thyroid carcinoma