title: Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source.
abstract: A novel palladium catalyzed hydroxylation of unactivated aliphatic C(sp(3))-H bonds was successfully developed. Different from conventional methods, water serves as the hydroxyl group source in the reaction. This new reaction demonstrates good reactivity and broad functional group tolerance. The C-H hydroxylated products can be readily transformed into various highly valuable chemicals via known transformations. Based on experimental and theoretical studies, a mechanism involving the Pd(II)/(IV) pathway is proposed for this hydroxylation reaction.
authors: MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. yrao@mail.tsinghua.edu.cn.
authors: Jiantao
authors: J
authors: Hu
authors: Tianlong
authors: T
authors: Lan
authors: Yihua
authors: Y
authors: Sun
authors: Hui
authors: H
authors: Chen
authors: Jiannian
authors: J
authors: Yao
authors: Yu
authors: Y
authors: Rao
mesh_terms: D002384:Catalysis; D006900:Hydroxylation; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D010165:Palladium; D010100:Oxygen