title: Primary pleural angiosarcoma associated with pneumoconiosis: An autopsy case.
abstract: We report a case of pleural angiosarcoma in an adult male patient confirmed by autopsy and possibly associated with pneumoconiosis. The lesion was characterized by thickened pleura of both lungs with nodular tumors. Histologically, the tumor was composed of spindle-to-polygonal epithelioid cells that were positive for CD31, CD34, vimentin, and cytokeratin on immunohistochemical staining but were negative for calretinin. Further examination revealed mix-dust pathological findings consistent with the existence of pneumoconiosis; dystrophic ossification, anthracosis, and fractal small dust particles were observed in the lung parenchyma and a hilar lymph node. The current case suggests that pneumoconiosis-associated pathologies may be risk factors for the development of angiosarcoma in the pleura.
authors: Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Hospital, Nagasaki, Japan.
authors: Katsuya
authors: K
authors: Matsuda
authors: Nagasaki Kawatana Medical Center, Surgery, National Hospital Organization, Nagasaki, Japan.
authors: Takeshi
authors: T
authors: Yamaryo
authors: Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Hospital, Nagasaki, Japan.|Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan.
authors: Yuko
authors: Y
authors: Akazawa
authors: Nagasaki Kawatana Medical Center, Surgery, National Hospital Organization, Nagasaki, Japan.
authors: Kenji
authors: K
authors: Kawakami
authors: Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Hospital, Nagasaki, Japan.
authors: Masahiro
authors: M
authors: Nakashima
mesh_terms: D000369:Aged, 80 and over; D001344:Autopsy; D003937:Diagnosis, Differential; D015622:Epithelioid Cells / Q000473:pathology; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008654:Mesothelioma / Q000473:pathology*; D010994:Pleura / Q000473:pathology; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000473:pathology*; D011009:Pneumoconiosis / Q000175:diagnosis / Q000473:pathology*
keywords: autopsy; pleural angiosarcoma; pneumoconiosis