title: Therapeutic hyperthermia: The old, the new, and the upcoming.
abstract: Hyperthermia has long been used for cancer treatment, either alone or in combination with chemotherapy, radiation therapy, or both. Its efficacy and versatility continue to be well demonstrated in randomized trials across a number of primary cancers, but barriers to its widespread adoption persist including effective delivery and verification systems. This article describes hyperthermia, details its biological mechanisms of action and immunological effects, and summarizes select preclinical data and key clinical trials combining hyperthermia with standard cancer treatments. Current challenges and emerging technologies that have the potential to make this translational therapy more accessible to a greater number of patients are also described.
authors: Virginia Commonwealth University, Internal Medicine, Richmond, VA 23298, USA. Electronic address: mlm3xe@virginia.edu.
authors: Matthew
authors: M
authors: Mallory
authors: New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA. Electronic address: gogie42@gmail.com.
authors: Emile
authors: E
authors: Gogineni
authors: Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, MD, 20892, USA. Electronic address: guy.jones@nih.gov.
authors: Guy C
authors: GC
authors: Jones
authors: Department of Radiation Oncology, Fort Belvoir Community Hospital, 9300 DeWitt Loop Fort Belvoir, 22060, VA, USA. Electronic address: Lester.l.greer.mil@health.mil.
authors: Lester
authors: L
authors: Greer
authors: Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia PA 19104, USA. Electronic address: charles.simone@uphs.upenn.edu.
authors: Charles B
authors: CB
authors: Simone
mesh_terms: D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000706:statistics & numerical data / Q000639:trends*; D055633:Immune System Phenomena / Q000502:physiology; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
keywords: Heat therapy; Hyperthermia; IMRT; Radiation therapy