title: YKL-40/CHI3L1 drives inflammation on the road of tumor progression.
abstract: Inflammation plays a vital role at different stages of tumor progression. The development of tumors is affected by inflammatory mediators produced by the tumor and the host. YKL-40/chitinase-3-like-1 protein is often up-regulated in inflammation-associated diseases. With the use of chronic inflammatory disease systems, we describe the role of YKL-40/chitinase-3-like-1 protein in enhancing the inflammatory response and its implications in tumorigenesis. We also discuss how pre-existing inflammation enhances tumor growth and metastasis. In this mini-review, we highlight the effect of YKL-40/chitinase-3-like-1 protein-associated inflammation in promoting tumor progression.
authors: Department of Biomedical Sciences, College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA.
authors: Stephania
authors: S
authors: Libreros
authors: Department of Biomedical Sciences, College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA iragavar@fau.edu.
authors: Vijaya
authors: V
authors: Iragavarapu-Charyulu
mesh_terms: D054392:Adipokines / Q000276:immunology*; D000818:Animals; D000071451:Chitinase-3-Like Protein 1; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D018836:Inflammation Mediators / Q000276:immunology*; D037102:Lectins / Q000276:immunology*; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D018836:Inflammation Mediators; D037102:Lectins; D009363:Neoplasm Proteins
keywords: angiogenesis; cytokines; inflammatory bowel; pulmonary inflammation