title: Comparison of the efficacy of cardamom (Elettaria cardamomum) with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats.
abstract: To evaluate the efficacy of cardamom with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats. There were four groups of 6 rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received cardamom suspension 1 g/kg/10 mL of 2% gum acacia orally 6 days before dexamethasone and 6 days during dexamethasone administration. Third group received pioglitazone 45 mg/kg orally 6 days before dexamethasone and 6 days during dexamethasone administration. Fourth group did not receive any medication and was considered as normal control. Fasting blood sugar, lipid profile, blood sugar 2 h after glucose load, liver weight, liver volume were recorded, and histopathological analysis was done. The effects of cardamom were compared with that of pioglitazone. Dexamethasone caused hepatomegaly, dyslipidemia and hyperglycemia. Both pioglitazone and cardamom significantly reduced hepatomegaly, dyslipidemia, and hyperglycemia (P < 0.01). Reduction of blood sugar levels after glucose load was significant with pioglitazone in comparison to cardamom (P < 0.01). Cardamom has comparable efficacy to pioglitazone in preventing dexamethasone-induced hepatomegaly, dyslipidemia, and fasting hyperglycemia.
authors: Department of Pharmacology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: G M
authors: GM
authors: Nitasha Bhat
authors: Department of Pharmacology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: Nagendra
authors: N
authors: Nayak
authors: Department of Pharmacology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: K
authors: K
authors: Vinodraj
authors: Department of Pharmacology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: N
authors: N
authors: Chandralekha
authors: Department of Pharmacology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: Paul
authors: P
authors: Mathai
authors: Medical Advisor, Onco and Nephro Division, Sun Pharma, Mumbai, Maharashtra, India.
authors: J
authors: J
authors: Cherian
keywords: Anti-diabetic; cardamom; insulin resistance; type 2 diabetes mellitus