title: Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients.
abstract: OBJECTIVE
  To compare outcomes between elderly (≥65 years old) and non-elderly (<65 years old) resuscitated severe sepsis and septic shock patients and determine predictors of death among elderly patients.
  
  
  METHODS
  Retrospective cohort study including 848 severe sepsis and septic shock patients admitted to the intensive care unit between January 2006 and March 2012.
  
  
  RESULTS
  Elderly patients accounted for 62.6% (531/848) and non-elderly patients for 37.4% (317/848). Elderly patients had a higher APACHE II score [22 (18-28)versus 19 (15-24); p<0.001], compared to non-elderly patients, although the number of organ dysfunctions did not differ between the groups. No significant differences were found in 28-day and in-hospital mortality rates between elderly and non-elderly patients. The length of hospital stay was higher in elderly compared to non-elderly patients admitted with severe sepsis and septic shock [18 (10-41)versus 14 (8-29) days, respectively; p=0.0001]. Predictors of death among elderly patients included age, site of diagnosis, APACHE II score, need for mechanical ventilation and vasopressors.
  
  
  CONCLUSIONS
  In this study population early resuscitation of elderly patients was not associated with increased in-hospital mortality. Prospective studies addressing the long-term impact on functional status and quality of life are necessary.
authors: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors: Henrique
authors: H
authors: Palomba
authors: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors: Thiago Domingos
authors: TD
authors: Corrêa
authors: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors: Eliézer
authors: E
authors: Silva
authors: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors: Andreia
authors: A
authors: Pardini
authors: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors: Murillo Santucci Cesar de
authors: MS
authors: Assuncao
mesh_terms: D018806:APACHE; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D061345:Early Medical Intervention / Q000379:methods; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012151:Resuscitation / Q000379:methods / Q000401:mortality*; D012189:Retrospective Studies; D018805:Sepsis / Q000401:mortality*; D012772:Shock, Septic / Q000401:mortality*; D015996:Survival Rate