title: Phenotyping Stroke in Sub-Saharan Africa: Stroke Investigative Research and Education Network (SIREN) Phenomics Protocol.
abstract: BACKGROUND
  As the second leading cause of death and the leading cause of adult-onset disability, stroke is a major public health concern particularly pertinent in Sub-Saharan Africa (SSA), where nearly 80% of all global stroke mortalities occur, and stroke burden is projected to increase in the coming decades. However, traditional and emerging risk factors for stroke in SSA have not been well characterized, thus limiting efforts at curbing its devastating toll. The Stroke Investigative Research and Education Network (SIREN) project is aimed at comprehensively evaluating the key environmental and genomic risk factors for stroke (and its subtypes) in SSA while simultaneously building capacities in phenomics, biobanking, genomics, biostatistics, and bioinformatics for brain research.
  
  
  METHODS
  SIREN is a transnational, multicentre, hospital and community-based study involving 3,000 cases and 3,000 controls recruited from 8 sites in Ghana and Nigeria. Cases will be hospital-based patients with first stroke within 10 days of onset in whom neurovascular imaging will be performed. Etiological and topographical stroke subtypes will be documented for all cases. Controls will be hospital- and community-based participants, matched to cases on the basis of gender, ethnicity, and age (±5 years). Information will be collected on known and proposed emerging risk factors for stroke. STUDY SIGNIFICANCE: SIREN is the largest study of stroke in Africa to date. It is anticipated that it will shed light on the phenotypic characteristics and risk factors of stroke and ultimately provide evidence base for strategic interventions to curtail the burgeoning burden of stroke on the sub-continent.
authors: Korle-Bu Teaching Hospital, Accra, Ghana.
authors: Albert
authors: A
authors: Akpalu
authors: Fred Stephen
authors: FS
authors: Sarfo
authors: Bruce
authors: B
authors: Ovbiagele
authors: Rufus
authors: R
authors: Akinyemi
authors: Mulugeta
authors: M
authors: Gebregziabher
authors: Reginald
authors: R
authors: Obiako
authors: Lukman
authors: L
authors: Owolabi
authors: Kwamena
authors: K
authors: Sagoe
authors: Carolyn
authors: C
authors: Jenkins
authors: Oyedunni
authors: O
authors: Arulogun
authors: Sheila
authors: S
authors: Adamu
authors: Lambert T
authors: LT
authors: Appiah
authors: Martin A
authors: MA
authors: Adadey
authors: Francis
authors: F
authors: Agyekum
authors: Joseph A
authors: JA
authors: Quansah
authors: Yaw B
authors: YB
authors: Mensah
authors: Abiodun M
authors: AM
authors: Adeoye
authors: Arti
authors: A
authors: Singh
authors: Aridegbe O
authors: AO
authors: Tosin
authors: Osimhiarherhuo
authors: O
authors: Ohifemen
authors: Abubabkar A
authors: AA
authors: Sani
authors: Eric
authors: E
authors: Tabi-Ajayi
authors: Ibinaiye O
authors: IO
authors: Phillip
authors: Suleiman Y
authors: SY
authors: Isah
authors: Nasir A
authors: NA
authors: Tabari
authors: Aliyu
authors: A
authors: Mande
authors: Atinuke M
authors: AM
authors: Agunloye
authors: Godwin I
authors: GI
authors: Ogbole
authors: Joshua O
authors: JO
authors: Akinyemi
authors: Onoja M
authors: OM
authors: Akpa
authors: Ruth
authors: R
authors: Laryea
authors: Sylvia Ezinne
authors: SE
authors: Melikam
authors: Dorcas
authors: D
authors: Adinku
authors: Ezinne
authors: E
authors: Uvere
authors: Nina-Serena
authors: NS
authors: Burkett
authors: Gregory F
authors: GF
authors: Adekunle
authors: Salaam I
authors: SI
authors: Kehinde
authors: Paschal C
authors: PC
authors: Azuh
authors: Abdul H
authors: AH
authors: Dambatta
authors: Naser A
authors: NA
authors: Ishaq
authors: Donna
authors: D
authors: Arnett
authors: Hemant K
authors: HK
authors: Tiwari
authors: Dan
authors: D
authors: Lackland
authors: Mayowa
authors: M
authors: Owolabi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002985:Clinical Protocols; D005500:Follow-Up Studies; D005869:Ghana / Q000453:epidemiology; D006801:Humans; D009549:Nigeria / Q000453:epidemiology; D010641:Phenotype; D012107:Research Design; D012307:Risk Factors; D020521:Stroke / Q000145:classification* / Q000453:epidemiology / Q000209:etiology*