title: Rare variants in the spectrum of human herpesvirus 8/Epstein-Barr virus-copositive lymphoproliferations.
abstract: We report 2 rare variants in the spectrum of human herpesvirus 8 (HHV8)/Epstein-Barr virus (EBV)-copositive lymphoproliferations arising in HIV-seronegative patients, including a large B-cell lymphoma arising in the setting of multicentric Castleman disease and a germinotropic lymphoproliferative disorder. In the first case, histology revealed features of multicentric Castleman disease and a proliferation of large lymphoid cells forming clusters or arcs or rings replacing the periphery of follicles or sheets of frank lymphoma outside the follicles. In the second case, a proliferation of large lymphoid cells totally or partially invaded follicle germinal centers. In both cases, the large cells were positive for EBV-encoded small RNA, HHV8 (LANA-1), MUM1/IRF4, and CD38 and negative for CD45, CD79a, CD10, BCL6, and CD138. In the large B-cell lymphoma, the large cells did not express detectable cytoplasmic immunoglobulin light- and heavy-chains, whereas in the germinotropic lymphoproliferative disorder, the large cells expressed μ heavy chain. The present cases broaden the spectrum of HHV-EBV--copositive lymphoproliferations.
authors: Department of Pathology, Faculty of Medicine, University of Ioannina, Ioannina 45110, Greece. Electronic address: apapoudoubai@gmail.com.
authors: Alexandra
authors: A
authors: Papoudou-Bai
authors: Department of Hematology, Faculty of Medicine, University of Ioannina, Ioannina 45110, Greece.
authors: Eleftheria
authors: E
authors: Hatzimichael
authors: Department of Hematology, Faculty of Medicine, University of Ioannina, Ioannina 45110, Greece.
authors: Lydia
authors: L
authors: Kyriazopoulou
authors: Department of Hematology, Faculty of Medicine, University of Ioannina, Ioannina 45110, Greece.
authors: Evangelos
authors: E
authors: Briasoulis
authors: Department of Anatomy-Histology-Embryology, Faculty of Medicine, University of Ioannina, Ioannina 45110, Greece.
authors: Panagiotis
authors: P
authors: Kanavaros
mesh_terms: D000368:Aged; D060085:Coinfection; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000473:pathology / Q000821:virology*; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human; D019288:Herpesvirus 8, Human; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged
keywords: Castleman’s disease; EBV; Germinotrophic; HHV-8; Large B-cell lymphoma; Lymphoproliferative disorder