title: May progesterone receptor membrane component 1 (PGRMC1) predict the risk of breast cancer?
abstract: OBJECTIVE
  Our and other studies have pointed on an important role of progesterone receptor membrane component 1 (PGRMC1) in development of breast cancer, especially in hormone therapy. To investigate if PGRMC1 could be used to predict the risk for getting breast cancer, we assessed in tissues of patients with primary invasive breast cancer, if the expression of PGRMC1 may be associated with the expression of estrogen receptor alpha (ERα), progesterone receptor (PR), and ki67.
  
  
  METHODS
  Samples from 109 patients with breast cancer between the years 2008 and 2014 were obtained with the patients' consent. Each sample was evaluated for the ERα, PR, Ki67, and PGRMC1 expression by immunohistochemistry using serial sections from the ame paraffin block comparing malignant tissue to benign tissue.
  
  
  RESULTS
  Expression of PGRMC1 is increased in tumor area compared with non-cancerous tissue and positively correlates with ERα expression (OR = 1.42 95%CI 1.06-1.91, p = 0.02). No association was obtained between expression of PGRMC1 and PR or Ki67.
  
  
  CONCLUSIONS
  It can be suggested that women with breast epithelium highly expressing PGRMC1 and in interaction with ERα may have an increased risk to develop breast cancer, especially when treated with hormone therapy.
authors: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China .
authors: Ying
authors: Y
authors: Zhang
authors: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China .|b Department of Endocrinology and Menopause , University Women's Hospital of Tuebingen , Tuebingen , Germany , and.
authors: Xiangyan
authors: X
authors: Ruan
authors: c Department of Gynecology and Obstetrics , University Women's Hospital of Duesseldorf , Duesseldorf , Germany.
authors: Marina
authors: M
authors: Willibald
authors: b Department of Endocrinology and Menopause , University Women's Hospital of Tuebingen , Tuebingen , Germany , and.
authors: Harald
authors: H
authors: Seeger
authors: c Department of Gynecology and Obstetrics , University Women's Hospital of Duesseldorf , Duesseldorf , Germany.
authors: Tanja
authors: T
authors: Fehm
authors: c Department of Gynecology and Obstetrics , University Women's Hospital of Duesseldorf , Duesseldorf , Germany.
authors: Hans
authors: H
authors: Neubauer
authors: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China .|b Department of Endocrinology and Menopause , University Women's Hospital of Tuebingen , Tuebingen , Germany , and.
authors: Alfred O
authors: AO
authors: Mueck
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D016015:Logistic Models; D008565:Membrane Proteins / Q000378:metabolism*; D060787:Neoplasm Grading; D011980:Receptors, Progesterone / Q000378:metabolism*; D012306:Risk
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D019394:Ki-67 Antigen; D008565:Membrane Proteins; C115296:PGRMC1 protein, human; D011980:Receptors, Progesterone
keywords: Breast cancer; Ki67; estrogen receptor (ER); progesterone receptor (PR); progesterone receptor membrane component 1 (PGRMC1)