title: PAX6 expression may be protective against dopaminergic cell loss in Parkinson's disease.
abstract: The transcription factor Pax6 is a well-accepted neurogenic determinant during development, in adult neural progenitor cells and in acute brain injury models. In the adult brain Pax6 is expressed in selective populations of dopaminergic neurons, and thus may have a role to play in Parkinson's disease (PD). This study looked at post-mortem tissue from patients with PD and in particular the substantia nigra which showed a reduced number of PAX6+ cells compared to age and sex matched control tissue. In an animal model of PD, there was an early transient increase in the number of SN Pax6+ cells at the time of cell loss through apoptosis. Finally we showed that an over-expression of Pax6 in SH-SY5Y cells treated with PD relevant neurotoxins, resulted in an increase in cell survival and a reduction in markers of apoptosis and oxidative stress. These results suggest that Pax6 may have a role to play in the loss of dopaminergic neurons in PD.
authors: Meghan G
authors: MG
authors: Thomas
authors: Caitlyn
authors: C
authors: Welch
authors: Leah
authors: L
authors: Stone
authors: Peter
authors: P
authors: Allan
authors: Roger A
authors: RA
authors: Barker
authors: University of Western Australia, Mail Box M092, Crawley WA 6009, Australia. robert.white@uwa.edu.au.
authors: Robert B
authors: RB
authors: White
mesh_terms: D000368:Aged; D000818:Animals; D002452:Cell Count / Q000379:methods; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D059290:Dopaminergic Neurons / Q000378:metabolism* / Q000473:pathology; D005136:Eye Proteins / Q000096:biosynthesis*; D005260:Female; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000096:biosynthesis*; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012097:Repressor Proteins / Q000096:biosynthesis*; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology
chemical_list: D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; C000605733:Pax6 protein, rat; D012097:Repressor Proteins