title: Impact of NIHR HTA Programme funded research on NICE clinical guidelines: a retrospective cohort.
abstract: BACKGROUND
  It is vitally important that there is a connection between health research and clinical practice. Indications as to the impact of the research on evidence-based practice and policy can be obtained by tracking the use of outputs of health research, especially its use in clinical guidelines (CGs). This study aims to assess the proportion of National Institute for Health and Care Excellence (NICE) CGs citing National Institute for Health Research Health Technology Assessment (NIHR HTA) studies and the impact of evidence from those studies on the included NICE CGs.
  
  
  METHODS
  This is a retrospective cohort study assessing the proportion of NICE CGs from all NICE CGs issued between April 2001 and April 2012, which cited evidence from studies funded by the NIHR HTA Programme and the impact of those studies on the CGs as the primary and secondary outcome measures.
  
  
  RESULTS
  Of the cohort of NICE CGs (n = 122), 3 (2%) CGs were based on previous NIHR HTA reports and would not have been issued in that form without those NIHR HTA studies, 90 (74%) included evidence from NIHR HTA studies, and 29 (24%) did not include evidence from NIHR HTA studies. The impact of NIHR HTA evidence on NICE CGs varied in the type and quantity of data used.
  
  
  CONCLUSIONS
  Findings suggest that NIHR HTA funded research impacts on clinical guidance from NICE and hence is well connected to both clinical practice and policy.
authors: National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre (NETSCC), University of Southampton, Alpha House, Enterprise Road, Southampton, SO16 7NS, UK. s.turner@soton.ac.uk.
authors: Sheila
authors: S
authors: Turner
authors: National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre (NETSCC), University of Southampton, Alpha House, Enterprise Road, Southampton, SO16 7NS, UK.
authors: Sheetal
authors: S
authors: Bhurke
authors: University of Southampton, Wessex Institute and University Hospital Southampton NHS Foundation Trust, University of Southampton, Alpha House, Enterprise Road, Southampton, SO16 7NS, UK.
authors: Andrew
authors: A
authors: Cook
mesh_terms: D000047:Academies and Institutes; D019317:Evidence-Based Medicine; D006078:Government Programs; D006302:Health Services Research; D006801:Humans; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D013673:Technology Assessment, Biomedical; D057170:Translational Research, Biomedical; D006113:United Kingdom