title: Brain ventricular dimensions and relationship to outcome in adult patients with bacterial meningitis.
abstract: BACKGROUND
  Experimental studies suggest that changes in brain ventricle size are key events in bacterial meningitis. This study investigated the relationship between ventricle size, clinical condition and risk of poor outcome in patients with bacterial meningitis.
  
  
  METHODS
  Adult patients diagnosed with bacterial meningitis admitted to two departments of infectious diseases from 2003 through 2010 were identified. Clinical and biochemical data as well as cerebral computed tomographic images were collected. The size of the brain ventricles were presented as a Ventricle to Brain Ratio (VBR). Normal range of VBR was defined from an age matched control group. A multivariate analysis was performed to identify predictors of 30-day mortality.
  
  
  RESULTS
  One hundred and seven patients were included. Eighty-one patients had a CT scan at the time of diagnosis. VBR was identified as an independent risk factor of 30-day mortality, Mortality Rate Ratio: 6.03 (95 % confidence interval: 1.61-22.64, p = 0.008) for highest versus lowest tertile. A VBR deviating more than 2 standard deviations from the normal range was associated with increased mortality.
  
  
  CONCLUSIONS
  Brain ventricles are commonly subject to marked changes in size as a consequence of meningitis. Increased brain ventricle size in the acute phase of bacterial meningitis was associated with increased mortality.
authors: Department of Pulmonary and Infectious Diseases, Hillerød Hospital, University of Copenhagen, Copenhagen, Denmark. janni.l.sporrborn@gmail.com.
authors: Janni L
authors: JL
authors: Sporrborn
authors: Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark. gertrud_bk@hotmail.com.
authors: Gertrud B
authors: GB
authors: Knudsen
authors: Department of Pulmonary and Infectious Diseases, Hillerød Hospital, University of Copenhagen, Copenhagen, Denmark. mettesolling@hotmail.com.
authors: Mette
authors: M
authors: Sølling
authors: Department of Diagnostic Radiology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark. kseieroe@gmail.com.
authors: Karina
authors: K
authors: Seierøe
authors: Department of Clinical Biochemistry, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark. annette.farre@hvh.regionh.dk.
authors: Annette
authors: A
authors: Farre
authors: Department of Pulmonary and Infectious Diseases, Hillerød Hospital, University of Copenhagen, Copenhagen, Denmark. bjarne.oerskov.lindhardt.01@regionh.dk.
authors: Bjarne Ø
authors: BØ
authors: Lindhardt
authors: Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark. tlb@dadlnet.dk.
authors: Thomas
authors: T
authors: Benfield
authors: Department of Pulmonary and Infectious Diseases, Hillerød Hospital, University of Copenhagen, Copenhagen, Denmark. dr.cbrandt@gmail.com.
authors: Christian T
authors: CT
authors: Brandt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging; D002552:Cerebral Ventricles / Q000473:pathology*; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000401:mortality; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed