title: Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease.
abstract: OBJECTIVE
  Patients with sickle cell disease may develop various macular vascular abnormalities that have not been described previously and can be seen using optical coherence tomographic angiography.
  
  
  METHODS
  Ten eyes from 5 consecutive patients (3 men and 2 women) with sickle cell disease (4 patients with hemoglobin SS disease and 1 patient with hemoglobin SC disease) were included. The mean age was 37.6 years. Five of 10 eyes (50%) had retinal thinning that was identified using spectral-domain optical coherence tomography. Each of these eyes had corresponding loss of vascular density in the superficial or deep retinal plexus (or both).
  
  
  CONCLUSIONS
  Optical coherence tomographic angiography provides a novel way to view the retinal vasculature, including the superficial and deep capillary plexus, and may provide a sensitive method for identifying macular vascular abnormalities in patients with sickle cell disease.
authors: Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.
authors: Ian C
authors: IC
authors: Han
authors: Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland2Retina Division, Department of Ophthalmology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
authors: Mongkol
authors: M
authors: Tadarati
authors: Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.
authors: Adrienne W
authors: AW
authors: Scott
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D009929:Organ Size; D011446:Prospective Studies; D012160:Retina / Q000473:pathology; D012164:Retinal Diseases / Q000175:diagnosis*; D012171:Retinal Vessels / Q000473:pathology*; D041623:Tomography, Optical Coherence