title: Enterococcal isolates carrying the novel oxazolidinone resistance gene optrA from hospitals in Zhejiang, Guangdong, and Henan, China, 2010-2014.
abstract: A collection of 1159 enterococcal isolates from five Chinese hospitals were screened for the presence of the novel oxazolidinone resistance gene optrA, which was found in 34 (2.9%) isolates. Pulsed-field gel electrophoresis (PFGE) typing of 29 optrA-carrying Enterococcus faecalis isolates revealed 25 PFGE patterns, and multilocus sequence typing yielded 20 sequence types. Routine surveillance of optrA-positive enterococci in hospitals should be conducted to monitor and counteract their further dissemination. The data of this study may be used as a baseline from which to judge future decreases or increases in optrA-positive enterococci.
authors: Clinical Microbiology Laboratory, The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China.
authors: J
authors: J
authors: Cai
authors: Department of Veterinary Pharmacology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors: Y
authors: Y
authors: Wang
authors: Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Neustadt-Mariensee, Germany.
authors: S
authors: S
authors: Schwarz
authors: Zhejiang Provincial People's Hospital, Hangzhou, China.
authors: H
authors: H
authors: Lv
authors: Henan Provincial People's Hospital, Zhengzhou, China.
authors: Y
authors: Y
authors: Li
authors: The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: K
authors: K
authors: Liao
authors: Taizhou Hospital, Taizhou, China.
authors: S
authors: S
authors: Yu
authors: The People's Hospital of Cixi, Cixi, China.
authors: K
authors: K
authors: Zhao
authors: Clinical Microbiology Laboratory, The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China.
authors: D
authors: D
authors: Gu
authors: Clinical Microbiology Laboratory, The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China.
authors: X
authors: X
authors: Wang
authors: Clinical Microbiology Laboratory, The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China.
authors: R
authors: R
authors: Zhang
authors: Department of Veterinary Pharmacology, College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address: sjz@cau.edu.cn.
authors: J
authors: J
authors: Shen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D002681:China; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D016983:Enterococcus / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D005798:Genes, Bacterial; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D023303:Oxazolidinones / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones
keywords: Antimicrobial resistance; enterococci; linezolid; molecular epidemiology; nosocomial infection; phenicols; tedizolid