title: Pharmacokinetics of tecomin in rats after intragastric and intravenous administration.
abstract: The pharmacokinetics of tecomin, which is a potential bioactive compound from the flowers of Trollius chinensis, was studied. The results showed that this compound was easily absorbed and rapidly metabolized into veratric acid in vivo, and then the latter was eliminated slowly. In addition, the simulant in vitro gastrointestinal transformation experiments demonstrated that the basic enteral environment and intestinal bacterial flora also contributed to the metabolism of tecomin to veratric acid.
authors: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
authors: Lina
authors: L
authors: Guo
authors: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
authors: Yushuai
authors: Y
authors: Peng
authors: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
authors: Can
authors: C
authors: Zhao
authors: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
authors: Xin
authors: X
authors: Yang
authors: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
authors: Lijia
authors: L
authors: Liu
authors: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
authors: Rufeng
authors: R
authors: Wang
mesh_terms: D061605:Administration, Intravenous; D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism* / Q000493:pharmacokinetics*; D035264:Flowers / Q000737:chemistry; D005750:Gastric Juice / Q000378:metabolism; D000069196:Gastrointestinal Microbiome; D007413:Intestinal Mucosa / Q000378:metabolism; D007419:Intestinal Secretions / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D029626:Ranunculaceae / Q000737:chemistry; D017207:Rats, Sprague-Dawley; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D000470:Alkaloids; D000893:Anti-Inflammatory Agents; C009333:veratric acid; D014641:Vanillic Acid; C003380:tecomine
keywords: intestinal bacteria; pharmacokinetics; tecomin; veratric acid