title: Medial orbitofrontal cortex lesion prevents facilitatory effects of d-cycloserine during fear extinction.
abstract: Animal models of fear extinction have an important clinical relevance to pharmacological and exposure-based therapies for anxiety disorders. Lesions of prefrontal structures impair fear extinction. On the other hand, d-cycloserine is able to enhance this process. We hypothesize that the integrity of cortical structures involved in inhibitory control of emotional responses is crucial for the facilitatory effects of d-cycloserine. Here, we showed that medial orbitofrontal cortex lesion prevents d-cycloserine enhancement of fear extinction. These preliminary results suggest that effects of pharmacological treatments could be dependent on cortical activity state to promote fear memory reduction.
authors: Laboratory of Neuroscience and Behavior, Department of Psychology, Universidad de los Andes, Colombia. Electronic address: sierra.ro@hotmail.com.
authors: Rodrigo O
authors: RO
authors: Sierra
authors: Laboratory of Neuroscience and Behavior, Department of Psychology, Universidad de los Andes, Colombia.
authors: Laura P
authors: LP
authors: Nítola
authors: Laboratory of Neuroscience and Behavior, Department of Psychology, Universidad de los Andes, Colombia.
authors: Johanna M
authors: JM
authors: Duran
authors: Laboratory of Neuroscience and Behavior, Department of Psychology, Universidad de los Andes, Colombia.
authors: Daysi R
authors: DR
authors: Prieto
authors: Laboratory of Neuroscience and Behavior, Department of Psychology, Universidad de los Andes, Colombia.
authors: Laura A
authors: LA
authors: León
authors: Laboratory of Neuroscience and Behavior, Department of Psychology, Universidad de los Andes, Colombia. Electronic address: lucarden@uniandes.edu.co.
authors: Fernando P
authors: FP
authors: Cardenas
mesh_terms: D000818:Animals; D003523:Cycloserine / Q000008:administration & dosage / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects*; D005239:Fear / Q000187:drug effects*; D008297:Male; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D003523:Cycloserine
keywords: Medial orbitofrontal cortex; Memory extinction; Rats; d-cycloserine