title: Results of intravitreal dexamethasone implant 0.7 mg (Ozurdex®) in non-infectious posterior uveitis.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of dexamethasone implant in patients with non-infectious posterior uveitis with cystoid macular edema (CME).
  
  
  METHODS
  Retrospective analysis of patients reports with CME secondary to non-infectious uveitis treated with dexamethasone implant. Data included type of posterior uveitis, any systemic immunosuppressive therapy, Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA), central macular thickness (CMT) on optical coherence tomography (OCT) and signs of intraocular inflammation at baseline and then at 2wk postoperatively and monthly thereafter. Follow-up is up to 10mo. Any per-operative and post-operative complications were recorded.
  
  
  RESULTS
  Six eyes of 4 patients with CME due to non-infectious posterior uveitis treated with dexamethasone implant. Diagnosis included idiopathic panuveitis, birdshot chorioretinopathy and idiopathic intermediate uveitis. At baseline mean ETDRS BCVA was 63 letters and mean CMT 556 µm at 2wk postoperatively mean ETDRS BCVA improved to 70 letters and mean CMT decreased to 329 µm. All eyes showed clinical evidence of decreased inflammation. The duration of effect of the implant was 5 to 6mo and retreatment was required in 2 eyes. Two patients required antiglaucoma therapy for increased intraocular pressures.
  
  
  CONCLUSIONS
  In patients with non-infectious posterior uveitis dexamethasone implant can be a short-term effective treatment option for controlling intraocular inflammation.
authors: Department of Ophthalmology, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK.
authors: Yew Chong
authors: YC
authors: Yap
authors: Department of Ophthalmology, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK.
authors: Thomas
authors: T
authors: Papathomas
authors: Department of Ophthalmology, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK.
authors: Ahmed
authors: A
authors: Kamal
keywords: Ozurdex®; central macular thickness; cystoids macular oedema; posterior uveitis