title: MiR-34b/c rs4938723 Polymorphism Significantly Decreases the Risk of Digestive Tract Cancer: Meta-analysis.
abstract: BACKGROUND
  Previous studies investigating the association between miR-34b/c rs4938723 polymorphism and cancer risk showed inconclusive. Here, we performed meta-analysis to investigate the association between miR- 34b/c rs4938723 polymorphism and digestive cancer risk.
  
  
  METHODS
  Literature database including PubMed, OVID, Chinese National Knowledge Infrastructure (CNKI) were searched for publications concerning the association between the miR-34b/c rs4938723 polymorphism and digestive cancer risk.
  
  
  RESULTS
  A total of 6 studies consisting of 3246 cases and 3568 controls were included in this meta-analysis. The combined analysis suggested the miR-34b/c rs4938723 polymorphism significantly reduced digestive cancer risk under allelic model, homogeneous co-dominant model and recessive model (C vs T: OR=0.88, 95%CI=0.82-0.95, p-value=0.001; CC vs TT: OR =0.67, 95%CI=0.57-0.80, p-value=0.000; CC vs
  OR=0.68, 95%CI=0.58-0.80, p-value=0.000). Q-test and I2 test revealed no significant heterogeneity in all genotype comparisons. The Begger's funnel plot and Egger's test did not show significant publication bias.
  
  
  CONCLUSIONS
  The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers.
authors: Department of Clinical Laboratory, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China E-mail : dream125@126.com, jitianxing7021@163.com.
authors: Tian-Xing
authors: TX
authors: Ji
authors: Cheng
authors: C
authors: Zhi
authors: Xue-Guang
authors: XG
authors: Guo
authors: Qiang
authors: Q
authors: Zhou
authors: Guo-Qiang
authors: GQ
authors: Wang
authors: Bo
authors: B
authors: Chen
authors: Fei-Fei
authors: FF
authors: Ma
mesh_terms: D004067:Digestive System Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: C522425:MIRN34 microRNA, human; D035683:MicroRNAs