title: Antioxidant, antibacterial and in vivo dermal wound healing effects of Opuntia flower extracts.
abstract: Opuntia ficus-indica flowers are used for various medicinal purposes. The aims of the present investigation were to evaluate biological properties of O. ficus-indica flowers extracts and to investigate its antioxidant and antibacterial activities and its ability to enhance wound healing. The wound healing activity of the mucilaginous and methanol extracts of O. ficus-indica flowers were assessed using excision wound model in rats. After thirteen days of treatment by both extracts, a beneficial effect on cutaneous repair was observed as assessed by the acceleration of wound contraction and remodeling phases. Histopathological studies of the granulation tissue indicated that the derma is properly arranged with the Opuntia flowers extract, compared with the control group. The mucilage extract was more effective than the methanol extract, but both showed significant results compared with the control. Such investigation was supported by the efficiency of the methanolic and mucilage extract as antimicrobial and antioxidant. Indeed, the extracts showed a potential antioxidant activity determined by different test systems, namely DPPH radicals scavenging activity, trolox equivalent antioxidant capacity, reducing power, β-carotene bleaching assay and metal chelating activity and exhibited significant antibacterial activity against almost all tested bacteria.
authors: Alimentary Analysis Laboratory, National School of Engineers of Sfax, Sfax University, 3038 Sfax, Tunisia. Electronic address: imene_ammar@yahoo.fr.
authors: Imene
authors: I
authors: Ammar
authors: Laboratory of Pharmacology, Faculty of Medicine of Sfax, Sfax University, Road Majida Boulila, 3028 Sfax, Tunisia.
authors: Sana
authors: S
authors: Bardaa
authors: Laboratory of Histology Embryology, Faculty of Medicine of Sfax, Sfax University, Road Majida Boulila, 3028 Sfax, Tunisia.
authors: Massara
authors: M
authors: Mzid
authors: Laboratory of Pharmacology, Faculty of Medicine of Sfax, Sfax University, Road Majida Boulila, 3028 Sfax, Tunisia.
authors: Zouheir
authors: Z
authors: Sahnoun
authors: Laboratory of Histology Embryology, Faculty of Medicine of Sfax, Sfax University, Road Majida Boulila, 3028 Sfax, Tunisia.
authors: Tarak
authors: T
authors: Rebaii
authors: Alimentary Analysis Laboratory, National School of Engineers of Sfax, Sfax University, 3038 Sfax, Tunisia.
authors: Hamadi
authors: H
authors: Attia
authors: Alimentary Analysis Laboratory, National School of Engineers of Sfax, Sfax University, 3038 Sfax, Tunisia; Higher Institute of Applied Sciences & Technology of Mahdia, Monastir University, Sidi Messaoud, 5111 Mahdia, Tunisia.
authors: Monia
authors: M
authors: Ennouri
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D035264:Flowers / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D029747:Opuntia / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D010936:Plant Extracts
keywords: Biological activities; Opuntia flowers; Wound healing