title: Development of a lifestyle intervention using the MRC framework for diabetes prevention in people with impaired glucose regulation.
abstract: We report development of a group-based lifestyle intervention, Let's Prevent, using the UK Medical Research Council (MRC) framework, and delivered by structured education to prevent type 2 diabetes mellitus (T2DM) in people with impaired glucose regulation (IGR) in a UK multi-ethnic population.
  
  
  
  Diabetes Education and Self-Management for Ongoing and Newly Diagnosed (DESMOND) is the first national T2DM programme that meets National Institute for Health and Care Excellence criteria and formed the basis for Let's Prevent. An iterative cycle of initial development, piloting, collecting and collating qualitative and quantitative data, and reflection and modification, was used to inform and refine lifestyle intervention until it was fit for evaluation in a definitive randomized controlled trial (RCT). The programme encouraged IGR self-management using simple, non-technical language and visual aids.
  
  
  
  Qualitative and quantitative data suggested that intervention resulted in beneficial short-term behaviour change such as healthier eating patterns, improved health beliefs and greater participant motivation and empowerment. We also demonstrated that recruitment strategy and data collection methods were feasible for RCT implementation.
  
  
  
  Let's Prevent was developed following successful application of MRC framework criteria and the subsequent RCT will determine whether it is feasible, reliable and transferable from research into a real-world NHS primary healthcare setting.
  
  
  
  ISRCTN80605705.
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Jacqui
authors: J
authors: Troughton
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Sudesna
authors: S
authors: Chatterjee
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Siân E
authors: SE
authors: Hill
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Heather
authors: H
authors: Daly
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Lorraine
authors: L
authors: Martin Stacey
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Margaret A
authors: MA
authors: Stone
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Naina
authors: N
authors: Patel
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Kamlesh
authors: K
authors: Khunti
authors: Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Thomas
authors: T
authors: Yates
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Laura J
authors: LJ
authors: Gray
authors: Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
authors: Melanie J
authors: MJ
authors: Davies
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D005260:Female; D018149:Glucose Intolerance / Q000517:prevention & control*; D015438:Health Behavior; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D040242:Risk Reduction Behavior; D000073278:Self-Management / Q000379:methods; D006113:United Kingdom
keywords: complex intervention; diabetes prevention; impaired glucose regulation; structured education