title: Evaluation of serum and pleural levels of soluble B7-H4 in lung cancer patients with pleural effusion.
abstract: OBJECTIVE
  To evaluate the diagnostic value of sB7-H4 and CEA in both serum and pleural effusion of lung cancer patients.
  
  
  METHODS
  Levels of sB7-H4 and CEA in 90 patients with malignant pleural effusion due to lung cancer and 58 patients with benign pleural effusion were measured by ELISA.
  
  
  RESULTS
  The sB7-H4 and CEA levels in pleural effusion, serum and their ratio (F/S) were higher in lung cancer group than that in benign group (p < 0.01). The diagnostic efficiency of sB7-H4 combined CEA was superior to either sB7-H4 or CEA.
  
  
  CONCLUSIONS
  Measurement of sB7-H4 and CEA might be useful diagnostic value for malignant effusion.
authors: a Department of Respiratory Medicine , Nanjing Chest Hospital , Nanjing , Jiangsu , P.R. China .
authors: Chunhua
authors: C
authors: Xu
authors: Lihua
authors: L
authors: Qian
authors: Like
authors: L
authors: Yu
authors: Xiuwei
authors: X
authors: Zhang
authors: Qingbo
authors: Q
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D016066:Pleural Effusion, Malignant / Q000097:blood / Q000175:diagnosis / Q000378:metabolism*; D012680:Sensitivity and Specificity; D012995:Solubility; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1 / Q000032:analysis* / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1; C475826:VTCN1 protein, human
keywords: Benign/malignant; lung cancer; pleural effusion; soluble B7-H4