title: Gene-environment interactions in psychopathology throughout early childhood: a systematic review.
abstract: Up to 20% of children and adolescents worldwide suffer from mental health problems. Epidemiological studies have shown that some of these problems are already present at an early age. The recognition that psychopathology is a result of an interaction between individual experiences and genetic characteristics has led to an increase in the number of studies using a gene-environment approach (G×E). However, to date, there has been no systematic review of G×E studies on psychopathology in the first 6 years of life. Following a literature search and a selection process, 14 studies were identified and most (n=12) of the studies found at least one significant G×E effect. This review provides a systematic characterization of the published G×E studies, providing insights into the neurobiological and environmental determinants involved in the etiology of children's psychopathology.
authors: School of Psychology, CIPsi, University of Minho, Braga, Portugal.
authors: Raquel Q
authors: RQ
authors: Pinto
authors: Isabel
authors: I
authors: Soares
authors: Eduarda
authors: E
authors: Carvalho-Correia
authors: Ana R
authors: AR
authors: Mesquita
mesh_terms: D002648:Child; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D065886:Neurodevelopmental Disorders / Q000235:genetics* / Q000523:psychology*; D011599:Psychopathology