title: Epstein-Barr virus (EBV)--associated posttransplant lymphoproliferative disorder appearing as mandibular gingival ulcers.
abstract: Posttransplant lymphoproliferative disorders (PTLDs) comprise a spectrum of complications that affect immunocompromised patients following hematopoietic stem cell transplantation or solid organ transplantation. Its incidence varies depending on the transplanted organ, occurring in approximately 2.3% of kidney transplantations. A 31-year-old woman was referred to the Dental Clinic of the State University of Western Paraná for evaluation of an oral lesion. Her medical history revealed a previous diagnosis of hypertension, Epstein-Barr virus (EBV) seropositivity, and kidney transplantation 12 years prior. She was under standard immunosuppressive therapy. Intraoral examination identified a gingival necrotic lesion with extension to the posterior right lower alveolar bone. An incisional biopsy was performed. Histologic examination showed lymphocytic proliferation of cells with small and hyperchromatic nuclei, atypical mitosis, and cells with large and pale nuclei showing prominent nucleoli permeating connective tissue, muscle fibers, and adipocytes. Correlation of clinical, histologic, and immunohistochemical findings led to a diagnosis of polymorphic EBV-associated PTLD rich in B and T cells.
authors: Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors: Ana Carolina
authors: AC
authors: Amorim Pellicioli
authors: School of Dentistry, State University of Western Paraná, Cascavel, Brazil.
authors: Aline Alves
authors: AA
authors: Luciano
authors: School of Dentistry, State University of Western Paraná, Cascavel, Brazil.
authors: Ana Lúcia Carrinho Ayroza
authors: AL
authors: Rangel
authors: School of Dentistry, State University of Western Paraná, Cascavel, Brazil.
authors: Greison Rabelo
authors: GR
authors: de Oliveira
authors: Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors: Alan Roger
authors: AR
authors: Santos Silva
authors: Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors: Oslei Paes
authors: OP
authors: de Almeida
authors: Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. Electronic address: Pavargas@fop.unicamp.br.
authors: Pablo Agustin
authors: PA
authors: Vargas
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D005260:Female; D005882:Gingival Diseases / Q000821:virology*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000821:virology*; D008336:Mandibular Diseases / Q000821:virology*; D019226:Oral Ulcer / Q000821:virology*