title: Vitamin D Status in South Africa and Tuberculosis.
abstract: According to the World Health Organisation South Africa has the third highest tuberculosis (TB) incidence in the world, with an estimated 60 % incident cases having both TB and HIV. The South African National Tuberculosis Association (SANTA) recognized the importance of nutrition in the prevention and management of TB by including feeding schemes in community outreach programs. Vitamin D enhances innate immunity against mycobacterial infection through the antimicrobial peptide, cathelicidin. We reviewed studies on vitamin D status, its link with TB, and potential use in therapy in multiethnic South Africa with sunlight as primary source of vitamin D. Ethnicity, season, disease state, latitude, and urbanization are critical factors to be considered in vitamin D supplementation for prevention and treatment of TB.
authors: Department of Biochemistry, University of Johannesburg, Auckland Park Kingsway Campus, Auckland Park, PO Box 524, Johannesburg, 2006, Gauteng, South Africa.
authors: Abhimanyu
authors: Department of Biochemistry, University of Johannesburg, Auckland Park Kingsway Campus, Auckland Park, PO Box 524, Johannesburg, 2006, Gauteng, South Africa.
authors: Vanessa
authors: V
authors: Meyer
authors: Department of Biochemistry, University of Johannesburg, Auckland Park Kingsway Campus, Auckland Park, PO Box 524, Johannesburg, 2006, Gauteng, South Africa.
authors: Tamsyn Jacki
authors: TJ
authors: Jeffery
authors: Department of Biochemistry, University of Johannesburg, Auckland Park Kingsway Campus, Auckland Park, PO Box 524, Johannesburg, 2006, Gauteng, South Africa. lizab@uj.ac.za.
authors: Liza
authors: L
authors: Bornman
mesh_terms: D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D013019:South Africa / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology* / Q000276:immunology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25(OH)D; Deficiency; Insufficiency; South Africa; Tuberculosis; Vitamin D