title: Safety and Health Benefits of Novel Dietary Supplements Consisting Multiple Phytochemicals, Vitamins, Minerals and Essential Fatty Acids in High Fat Diet Fed Rats.
abstract: The objective was to determine safety and efficacy of health supplements "Beyond Tangy Tangerine," a multivitamin/mineral complex and combination of multivitamin/mineral complex, "Osteofx," a bone healthy supplement and "Ultimate Essential Fatty Acids" in Sprague Dawley rats consuming high-fat diets. Initially a pilot study was conducted which confirmed palatability and acceptability of supplements. In a second study, rats (n = 15/group) were randomized to Control; Multivitamin/mineral complex (2 g/kg BW) or Combination (2 g Multivitamin/mineral complex, 1.5 g Bone healthy supplement and 0.34 g Essential fatty acids/kg BW). No differences were observed in BW change, feed intake, organ weights or bone mineral composition with supplementations compared to control. Multivitamin/mineral complex supplementation decreased abdominal white adipose tissue weights (WAT) (p = .005), total (p = .033) and fat mass (p = .040), plasma IL-6 (p = .016) and ALKP (p = .038) and elevated plasma calcium (p < .001), phosphorus (p = .038), total protein (p = .002), albumin (p = .014) and globulin (p = .018), compared to control. Similarly, combination supplementation reduced WAT (p < .001), total (p = .023) and fat mass (p = .045), plasma triglycerides (p = .018), IL-6 (p = .002) and ALKP (p < .001) with increases in plasma calcium (p = .031), phosphorus (p < .001) compared to control. Results indicate that consuming either supplement can be considered safe and improves overall health by reducing inflammation, abdominal fat mass and plasma triglycerides, as well as promote bone health.
authors: a Richardson Centre for Functional Foods and Nutraceuticals , Winnipeg , Canada.|b Department of Human Nutritional Sciences , University of Manitoba , Winnipeg , Canada.
authors: Vanu Ramkumar
authors: VR
authors: Ramprasath
authors: a Richardson Centre for Functional Foods and Nutraceuticals , Winnipeg , Canada.|b Department of Human Nutritional Sciences , University of Manitoba , Winnipeg , Canada.
authors: Peter J H
authors: PJ
authors: Jones
mesh_terms: D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000097:blood; D059305:Diet, High-Fat; D019587:Dietary Supplements / Q000032:analysis*; D005228:Fatty Acids, Essential / Q000008:administration & dosage / Q000032:analysis*; D005916:Globulins / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010758:Phosphorus / Q000097:blood; D064209:Phytochemicals / Q000008:administration & dosage / Q000032:analysis*; D010865:Pilot Projects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000378:metabolism; D014131:Trace Elements / Q000008:administration & dosage / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D014815:Vitamins / Q000008:administration & dosage / Q000032:analysis*
chemical_list: D005228:Fatty Acids, Essential; D005916:Globulins; D015850:Interleukin-6; D064209:Phytochemicals; D012709:Serum Albumin; D014131:Trace Elements; D014280:Triglycerides; D014815:Vitamins; D010758:Phosphorus; D002118:Calcium
keywords: fat mass; health; minerals; supplement; vitamins