title: Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma.
abstract: OBJECTIVE
  Some studies have suggested that tubulocystic carcinoma may be related to papillary renal cell carcinoma. We sought to compare and contrast the molecular and immunohistochemical profiles of tubulocystic carcinoma with those of papillary renal cell carcinoma.
  
  
  RESULTS
  Twelve cases of pure tubulocystic renal cell carcinoma were subjected to fluorescence in-situ hybridization assessment of chromosomal number for chromosomes 7 and 17, and for TFE3 translocation. Immunohistochemical labelling for AMACR, p63, cytokeratin 7, PAX8, cytokeratin 20 and carbonic anhydrase IX was assessed in all tumours. No tumour showed gains of chromosomes 7 or 17, or TFE3 translocation by fluorescence in-situ hybridization. Immunohistochemistry revealed all tumours to be non-reactive with antibodies against p63 and cytokeratin 20. Conversely, the antibody against AMACR gave a positive reaction in the neoplastic cells of all tumours. Four tumours showed focal labelling with antibody against carbonic anhydrase IX, and five tumours showed focally positive reactions with antibody against cytokeratin 7. Recurrence and metastatic disease were not found for the patients with available follow-up information.
  
  
  CONCLUSIONS
  Pure tubulocystic renal cell carcinoma is an indolent tumour with a good prognosis. Our data support the distinction of this neoplasm as a separate entity.
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
authors: Thu
authors: T
authors: Tran
authors: Department of Pathology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.
authors: Carol L
authors: CL
authors: Jones
authors: Department of Pathology, Henry Ford Health System, Detroit, MI, USA.
authors: Sean R
authors: SR
authors: Williamson
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
authors: John N
authors: JN
authors: Eble
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
authors: David J
authors: DJ
authors: Grignon
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
authors: Shaobo
authors: S
authors: Zhang
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
authors: Mingsheng
authors: M
authors: Wang
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
authors: Lee Ann
authors: LA
authors: Baldridge
authors: Department of Pathology, Fudan University Shanghai Cancer Centre, Shanghai, China.
authors: Lisha
authors: L
authors: Wang
authors: Institute of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region (Ancona), United Hospitals, Ancona, Italy.
authors: Rodolfo
authors: R
authors: Montironi
authors: Institute of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region (Ancona), United Hospitals, Ancona, Italy.
authors: Marina
authors: M
authors: Scarpelli
authors: Singapore General Hospital, Singapore, Singapore.
authors: Puay-Hoon
authors: PH
authors: Tan
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
authors: Novae B
authors: NB
authors: Simper
authors: Department Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors: Eva
authors: E
authors: Comperat
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors: Liang
authors: L
authors: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002291:Carcinoma, Papillary / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor
keywords: fluorescence in-situ hybridization; immunohistochemistry; kidney; papillary renal cell carcinoma; tubulocystic renal cell carcinoma