title: Metallothionein expression in the rat brain following KA and PTZ treatment.
abstract: Epilepsy is a neurological disorder that has been associated with oxidative stress therefore epilepsy models have been develop such as kainic acid and pentylenetetrazol are usually used to understanding of the molecular mechanisms of this disease. We examined the metallothionein expression in rat brains of treated with kainic acid and pentylenetetrazol. Increase in metallothionein and nitrotirosyne immunoreactivity of both seizures epilepsy models was observed. Moreover, we show a significant increase on levels of MT expression. These results suggest that the increase of metallothionein expression is related with kainic acid and pentylenetetrazol treatments as response to damage mediated by oxidative stress.
authors: Lab. Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico.
authors: Daniel
authors: D
authors: Juárez-Rebollar
authors: Lab. Formación Reticular, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico.
authors: Joaquín
authors: J
authors: Manjarrez
authors: Lab. Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico.
authors: Concepción
authors: C
authors: Nava-Ruíz
authors: Lab. Biología Celular, Instituto Nacional de Perinatología, Isidro Espinosa de los Reyes, Mexico.
authors: Verónica
authors: V
authors: Zaga-Clavellina
authors: Lab. Biología Celular, Instituto Nacional de Perinatología, Isidro Espinosa de los Reyes, Mexico.
authors: Pilar
authors: P
authors: Flores-Espinosa
authors: Depto. Etología, Fauna Silvesre y Animales de Laboratorio, Facultad de Medicina Veterinaria y Zootecnia, U.N.A.M, Mexico.
authors: Yesica
authors: Y
authors: Heras-Romero
authors: Depto. Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico.
authors: Araceli
authors: A
authors: Díaz-Ruíz
authors: Lab. Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico. Electronic address: mmendezarmenta@hotmail.com.
authors: Marisela
authors: M
authors: Méndez-Armenta
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D007608:Kainic Acid / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008668:Metallothionein / Q000378:metabolism*; D018384:Oxidative Stress; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: C002744:3-nitrotyrosine; D014443:Tyrosine; D008668:Metallothionein; D007608:Kainic Acid; D010433:Pentylenetetrazole
keywords: Epilepsy; Kainic acid; Metallothionein; Oxidative stress; Pentylenetetrazol