title: Investigating Turkey Enteric Picornavirus and Its Association with Enteric Disease in Poults.
abstract: Previous research into the viral community in the poultry gastrointestinal tract has revealed a number of novel and partially described enteric viruses. It is evident that the poultry gut viral community remains minimally characterized and incompletely understood. Investigations into the microbiome of the poultry gut have provided some insight into the geographical distribution and the rapidly evolving taxonomy of the avian enteric picornaviruses. The present investigation was undertaken to produce a comparative metagenomic analysis of the gut virome from a healthy turkey flock versus a flock placed in the field. This investigation revealed a number of enteric picornavirus sequences that were present in the commercial birds in the field that were completely absent in the healthy flock. A novel molecular diagnostic assay was used to track the shedding of field strains of turkey enteric picornavirus in commercial poults inoculated with picornavirus-positive intestinal homogenates prepared from turkeys that were experiencing moderate enteric disease. The propagation of this novel enteric picornavirus in commercial poults resulted in significant reduction in weight gain, and suggests that this common inhabitant of the turkey gut may result in performance problems or enteric disease in the field.
authors: J Michael
authors: JM
authors: Day
authors: Laszlo
authors: L
authors: Zsak
mesh_terms: D000818:Animals; D004751:Enteritis / Q000662:veterinary* / Q000821:virology; D056186:Metagenomics; D010849:Picornaviridae / Q000145:classification* / Q000235:genetics; D010850:Picornaviridae Infections / Q000662:veterinary* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D014422:Turkeys / Q000196:embryology; D014776:Virus Cultivation; D015431:Weight Loss