title: ABO Blood Type and Response of Activated Partial Thromboplastin Time to Dabigatran in Nonvalvular Atrial Fibrillation Patients.
abstract: BACKGROUND
  The association between ABO blood type and the activated partial thromboplastin time (aPTT) under dabigatran therapy in nonvalvular atrial fibrillation (NVAF) patients is unclear.
  
  
  RESULTS
  Between 2011 March and 2015 May, data on ABO blood type and aPTT under dabigatran were obtained for 396 NVAF patients (baseline aPTT, 166). The prevalence of blood type O tended to increase or significantly increase according to baseline aPTT, aPTT under dabigatran, and their difference (∆aPTT) (P=0.054, 0.001, and 0.012, respectively).
  
  
  CONCLUSIONS
  In these NVAF patients, a high aPTT value under dabigatran therapy was associated with blood type O.
authors: Department of Cardiovascular Medicine, The Cardiovascular Institute.
authors: Shinya
authors: S
authors: Suzuki
authors: Takayuki
authors: T
authors: Otsuka
authors: Koichi
authors: K
authors: Sagara
authors: Hiroaki
authors: H
authors: Semba
authors: Hiroto
authors: H
authors: Kano
authors: Shunsuke
authors: S
authors: Matsuno
authors: Hideaki
authors: H
authors: Takai
authors: Yuko
authors: Y
authors: Kato
authors: Tokuhisa
authors: T
authors: Uejima
authors: Yuji
authors: Y
authors: Oikawa
authors: Kazuyuki
authors: K
authors: Nagashima
authors: Hajime
authors: H
authors: Kirigaya
authors: Takashi
authors: T
authors: Kunihara
authors: Junji
authors: J
authors: Yajima
authors: Hitoshi
authors: H
authors: Sawada
authors: Tadanori
authors: T
authors: Aizawa
authors: Takeshi
authors: T
authors: Yamashita
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000097:blood* / Q000188:drug therapy*; D000069604:Dabigatran / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time
chemical_list: D000017:ABO Blood-Group System; D000069604:Dabigatran