title: Oligoclonal Bands in Cerebrospinal Fluid of Black Patients with Multiple Sclerosis.
abstract: Genetic susceptibility is a well-recognized factor in the onset of multiple sclerosis (MS). The objective of this study was to determine the frequency of oligoclonal bands (OCB) restricted to the cerebrospinal fluid, in an ethnically mixed group of MS patients in the city of São Paulo, Brazil. Techniques used to detect OCB consisted of isoelectric focusing followed by immunoblotting. OCB were found in 49 (54.4%) out of 90 patients with clinically definite MS; out of the 23 brown/black patients, 17 (73.9%) were OCB+; out of the 66 white patients, 32 (48.5%) were OCB+; and the only patient yellow was OCB+ (p = 0.05). Analysis of the IgG index was also consistent with the findings, but with lower statistical significance. The data presented in our study show that the ethnic differences in MS extend to the immune response.
authors: Pontifical Catholic University of São Paulo, Rua Conde Fco Matarazzo 58, 18030-010 Sorocaba, SP, Brazil.
authors: Paulo Diniz
authors: PD
authors: da Gama
authors: University of São Paulo, São Paulo, SP, Brazil.
authors: Luís dos Ramos
authors: Ldos R
authors: Machado
authors: University of São Paulo, São Paulo, SP, Brazil.
authors: José Antonio
authors: JA
authors: Livramento
authors: Hospital Sírio-Libanês, São Paulo, SP, Brazil.
authors: Hélio Rodrigues
authors: HR
authors: Gomes
authors: Hospital Sírio-Libanês, São Paulo, SP, Brazil.
authors: Tarso
authors: T
authors: Adoni
authors: Federal University of Uberlândia, MG, Brazil.
authors: Rogério de Rizo
authors: Rde R
authors: Morales
authors: Pontifical Catholic University of São Paulo, Rua Conde Fco Matarazzo 58, 18030-010 Sorocaba, SP, Brazil.
authors: Rodrigo Assad Diniz
authors: RA
authors: da Gama
authors: Pontifical Catholic University of São Paulo, Rua Conde Fco Matarazzo 58, 18030-010 Sorocaba, SP, Brazil.
authors: Daniel Assad Diniz
authors: DA
authors: da Gama
authors: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors: Marco Aurélio
authors: MA
authors: Lana-Peixoto
authors: Metropolitan University of Santos, Santos, SP, Brazil.
authors: Yara Dadalti
authors: YD
authors: Fragoso
authors: Demyelinating Diseases Reference Center, Hospital das Clinicas, University of São Paulo, São Paulo, SP, Brazil.
authors: Dagoberto
authors: D
authors: Callegaro
mesh_terms: D044383:Black People / Q000235:genetics; D001938:Brazil; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000235:genetics; D007525:Isoelectric Focusing; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000235:genetics* / Q000473:pathology; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid / Q000235:genetics*
chemical_list: D007074:Immunoglobulin G; D043025:Oligoclonal Bands