title: mRNA-Producing Pseudo-nucleus System.
abstract: A pseudo-eukaryotic nucleus (PEN) system consisting of a gene-containing DNA hydrogel encapsulated in a liposome is fabricated. Owing to the structural characteristics of gene-containing DNA hydrogel, mRNA transcription efficiency is promoted 2.57-fold. Through the use of PEN as a platform for mRNA delivery to the cytosol, prolonged protein translation is achieved.
authors: School of Chemical Engineering, Sungkyunkwan University, Suwon, 440-746, Republic of Korea.
authors: Seung Won
authors: SW
authors: Shin
authors: School of Chemical Engineering, Sungkyunkwan University, Suwon, 440-746, Republic of Korea.
authors: Kyung Soo
authors: KS
authors: Park
authors: School of Chemical Engineering, Sungkyunkwan University, Suwon, 440-746, Republic of Korea.
authors: Woo Jung
authors: WJ
authors: Shin
authors: School of Chemical Engineering, Sungkyunkwan University, Suwon, 440-746, Republic of Korea.|SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon, 440-746, Republic of Korea.
authors: Soong Ho
authors: SH
authors: Um
mesh_terms: D058045:Artificial Cells / Q000737:chemistry*; D002467:Cell Nucleus / Q000737:chemistry*; D011088:DNA Ligases / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D035683:MicroRNAs / Q000138:chemical synthesis*; D010957:Plasmids / Q000737:chemistry*
chemical_list: D008081:Liposomes; D035683:MicroRNAs; D011088:DNA Ligases
keywords: DNA nanotechnology; artificial cell nucleus; biomimicry; messenger RNA expression; nucleus mimicry