title: Adrenal insufficiency secondary to lymphocytic panhypophysitis in a cat.
abstract: METHODS
  A 13-year-old male castrated Domestic Shorthair cat was presented for investigation of lethargy, vomiting, polydipsia and polyuria. Glucocorticoid-deficient hypoadrenocorticism was suspected based on hypocholesterolaemia, hypoglycaemia and lack of a stress leucogram, and confirmed with an ACTH stimulation test. Pituitary disease was suspected based on the clinical signs and the combination of hyposthenuria and hypernatraemia. Necropsy revealed bilaterally symmetric adrenocortical atrophy and the changes in the pituitary gland were suggestive of a T-cell-rich immune-mediated panhypophysitis.
  
  
  CONCLUSIONS
  Secondary adrenal insufficiency and panhypophysitis have not been previously reported in the cat. This report should raise awareness of this rare but potentially treatable disease process.
authors: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA. rudinsky.3s@osu.edu.
authors: A J
authors: http://orcid.org/0000-0001-5369-3152
authors: AJ
authors: Rudinsky
authors: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
authors: E S
authors: ES
authors: Clark
authors: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
authors: D S
authors: DS
authors: Russell
authors: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
authors: C
authors: C
authors: Gilor
mesh_terms: D000311:Adrenal Glands / Q000473:pathology; D000309:Adrenal Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000069281:Autoimmune Hypophysitis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D002415:Cats; D008297:Male
keywords: cats; hypoadrenocorticism; hypopituitarism; immune-mediated disease