title: Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations.
abstract: OBJECTIVE
  We investigate the role of ethnicity and admixture in drug response across a broad group of chemotherapeutic drugs. Also, we generate hypotheses on the genetic variants driving differential drug response through multivariate genome-wide association studies.
  
  
  METHODS
  Immortalized lymphoblastoid cell lines from 589 individuals (Hispanic or non-Hispanic/Caucasian) were used to investigate dose-response for 28 chemotherapeutic compounds. Univariate and multivariate statistical models were used to elucidate associations between genetic variants and differential drug response as well as the role of ethnicity in drug potency and efficacy.
  
  
  CONCLUSIONS
  For many drugs, the variability in drug response appears to correlate with self-reported race and estimates of genetic ancestry. Additionally, multivariate genome-wide association analyses offered interesting hypotheses governing these differential responses.
authors: Department of Statistics, North Carolina State University, 2601 Stinson Drive, Raleigh, NC 27695, USA.|Bioinformatics Research Center, North Carolina State University, 2601 Stinson Drive, Raleigh, NC 27695, USA.
authors: John
authors: J
authors: Jack
authors: Center for Pharmacogenomics & Individualized Therapy, University of North Carolina, 120 Mason Farm Road, Chapel Hill, NC 27514, USA.
authors: Tammy M
authors: TM
authors: Havener
authors: DeBartolo Family Personalized Medicine Institute, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.|Pharmacogenetics for Every Nation Initiative, 1119 Oxbridge Drive, Tampa, FL 33549, USA.
authors: Howard L
authors: HL
authors: McLeod
authors: Department of Statistics, North Carolina State University, 2601 Stinson Drive, Raleigh, NC 27695, USA.|Bioinformatics Research Center, North Carolina State University, 2601 Stinson Drive, Raleigh, NC 27695, USA.
authors: Alison A
authors: AA
authors: Motsinger-Reif
authors: Lineberger Comprehensive Cancer Center, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27514, USA.
authors: Matthew
authors: M
authors: Foster
mesh_terms: D001741:Black or African American; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D015331:Cohort Studies; D005006:Ethnicity; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006630:Hispanic or Latino; D006801:Humans; D015999:Multivariate Analysis; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D016896:Treatment Outcome; D044465:White People
keywords: Caucasian; GWAS; admixture; cancer; cytotoxicity; drug; genome-wide association study; hispanic; in vitro; lymphoblastoid cell lines