title: The emergence of commodity-scale genetic manipulation.
abstract: Since the 1970s technological advancements in the fields of synthetic biology and metabolic engineering have led to a dramatic reduction in both time and cost required for generating genomic mutations in a variety of organisms. The union of genomic editing machinery, DNA inkjet printers, and bioinformatics algorithms allows engineers to design a library of thousands of unique oligos as well as build and test these designs on a ∼2 months time-scale and at a cost of roughly ∼0.3 cents per base pair. The implications of these capabilities for a variety of fields are far-reaching, with potential impacts in defense, agricultural, human health, and environmental research. The explosion of synthetic biology applications over the past two decades have led many to draw parallels between biological engineering and the computer sciences. In this review, we highlight some important parallels between these fields and emphasize the importance of engineering design strategies.
authors: Department of Chemical and Biological Engineering, University of Colorado Boulder, United States.
authors: Andrea L
authors: AL
authors: Halweg-Edwards
authors: Department of Chemistry and Biochemistry, University of Colorado, United States.
authors: William C
authors: WC
authors: Grau
authors: Department of Chemical and Biological Engineering, University of Colorado Boulder, United States.
authors: James D
authors: JD
authors: Winkler
authors: Department of Chemical and Biological Engineering, University of Colorado Boulder, United States.
authors: Andrew D
authors: AD
authors: Garst
authors: Department of Chemical and Biological Engineering, University of Colorado Boulder, United States. Electronic address: rtg@colorado.edu.
authors: Ryan T
authors: RT
authors: Gill
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000191:economics / Q000379:methods*; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry / Q000235:genetics*; D005818:Genetic Engineering / Q000191:economics / Q000379:methods*; D006801:Humans; D058615:Synthetic Biology / Q000191:economics / Q000379:methods*
chemical_list: D004247:DNA