title: Lack of association of CYP11B2-344C/T polymorphism with essential hypertension: a meta-analysis.
abstract: OBJECTIVE
  A meta-analysis was carried out to evaluate the correlation between CYP11B2-344C/T polymorphism and essential hypertension susceptibility.
  
  
  METHODS
  By retrieving relevant databases and collecting domestic and international literatures about the correlation between CYP11B2-344C/T polymorphism and essential hypertension, the quality of literature were evaluated according to NEWCASTLE-OTTAWA case-control study quality rating scale (NOS). RevMan 5.0 was used to select the best genetic model, analysis the heterogeneity, calculate combined OR and the 95% CI.
  
  
  RESULTS
  8532 subjects were included in this study. Compared with the control group, the OR (95% CI) values of dominant model, recessive model, and additive model were 1.01 (95% CI: 0.81~1.25), 1.03 (95% CI: 0.83~1.19) and 1.10 (95% CI: 0.93-1.29).
  
  
  CONCLUSIONS
  There is no evidence to confirm that CYP11B2 (-344C/T) polymorphism is associated with susceptibility of essential hypertension.
authors: Department of Cardiology, Xinqiao Hospital, The Third Military Medical University Chongqing 400037, China.
authors: Jian-Fei
authors: JF
authors: Chen
authors: Department of Cardiology, Xinqiao Hospital, The Third Military Medical University Chongqing 400037, China.
authors: Jun
authors: J
authors: Jing
authors: Department of Cardiology, Xinqiao Hospital, The Third Military Medical University Chongqing 400037, China.
authors: Hu
authors: H
authors: Tan
authors: Department of Cardiology, Xinqiao Hospital, The Third Military Medical University Chongqing 400037, China.
authors: Min-Bao
authors: MB
authors: Song
authors: Department of Cardiology, Xinqiao Hospital, The Third Military Medical University Chongqing 400037, China.
authors: Shi-Yong
authors: SY
authors: Yu
authors: Department of Cardiology, Xinqiao Hospital, The Third Military Medical University Chongqing 400037, China.
authors: Lan
authors: L
authors: Huang
keywords: CYP11B2; essential hypertension; meta-analysis; polymorphism