title: Effect of interleukin-6 polymorphism on fracture risk.
abstract: BACKGROUND
  Interleukin-6 (IL6) -174C/G polymorphism was suggested to be associated with fracture risk. However, the results were inconsistent. Thus, we did a meta-analysis.
  
  
  METHODS
  Reported studies were searched from online electronic databases of Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI). The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to assess the association between IL6 -174C/G polymorphism and fracture risk.
  
  
  RESULTS
  Six studies evaluated the association between IL6 -174C/G polymorphism and fracture risk. A significant association was found between IL6 -174C/G polymorphism and fracture risk (OR=1.25; 95% CI, 1.10-1.43; P=0.0008). In the subgroup analysis of gender, we found that women with IL6 -174C/G polymorphism had an increased fracture risk (OR=1.25; 95% CI, 1.07-1.46; P=0.005). In the subgroup analysis of type of fracture, we found that IL6 -174C/G polymorphism was significantly associated with wrist fracture (OR=1.25; 95% CI, 1.07-1.47; P=0.006) and osteoporotic fracture (OR=1.60; 95% CI, 1.12-2.28; P=0.009). However, no significant association was found between IL6 -174C/G polymorphism and hip fracture (OR=1.05; 95% CI, 0.89-1.24; P=0.53) and stress fracture (OR=1.25; 95% CI, 0.97-1.61; P=0.08).
  
  
  CONCLUSIONS
  This meta-analysis suggested that the IL6 -174C/G polymorphism was associated with wrist and osteoporotic fracture risk.
authors: Department of Othopedic, The Fist People's Hospital of Zhangjiagang Zhangjiagang 215600, Jiang Su, China.
authors: Chuangli
authors: C
authors: Wang
authors: Department of Othopedic, The Fist People's Hospital of Zhangjiagang Zhangjiagang 215600, Jiang Su, China.
authors: Jianfei
authors: J
authors: Ge
authors: Department of Othopedic, The Fist People's Hospital of Zhangjiagang Zhangjiagang 215600, Jiang Su, China.
authors: Shanjun
authors: S
authors: Ni
keywords: Fracture; genetics; interleukin-6