title: Bipolar disorder: Functional neuroimaging markers in relatives.
abstract: Neural models of anatomical and functional alterations have been proposed for bipolar disorders (BD). However, studies in affected patients do not allow disentangling alterations linked to the liability to BD from those associated with the evolution, medication and comorbidities of BD. Explorations in high risk subjects allow the study of these risk markers. We reported and summarized all functional magnetic resonance imaging (fMRI) studies focusing on first-degree relatives of BD patients. We found 29 studies reporting neural correlates of working memory (WM), emotional processing, executive functions and resting state in relatives of BD patients, compared to healthy subjects. Overall, the same regions that have been involved in patients, such as the inferior frontal gyrus and limbic areas, seem to be functionally altered in high-risk subjects. We conclude that the same brain regions already implicated in the pathophysiology of the disease such as the amygdala are also associated with the risk of BD. However longitudinal studies are required to understand their implication in the transition to BD.
authors: Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland; Department of Mental Health and Psychiatry, Geneva University Hospital, Switzerland. Electronic address: camille.piguet@unige.ch.
authors: Camille
authors: C
authors: Piguet
authors: Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland.
authors: Leon
authors: L
authors: Fodoulian
authors: Department of Mental Health and Psychiatry, Geneva University Hospital, Switzerland.
authors: Jean-Michel
authors: JM
authors: Aubry
authors: Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland; Department of Clinical Neuroscience, Geneva University Hospital, Switzerland.
authors: Patrik
authors: P
authors: Vuilleumier
authors: NeuroSpin Neuroimaging Center, UNIACT Lab, Psychiatry Team, CEA Saclay, France; INSERM U955 Team 15 "Translational Psychiatry", Université Paris Est, APHP, CHU Mondor, DHU PePsy, Pôle de Psychiatrie, Créteil, France; FondaMental Foundation, Créteil, France.
authors: Josselin
authors: J
authors: Houenou
mesh_terms: D001714:Bipolar Disorder / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D005190:Family; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging
keywords: Bipolar disorder; High-risk; Relatives; Vulnerability; fMRI