title: [Neuropsychological Functioning as a Predictor of Treatment Response to Psychoeducational, Cognitive Behavioral Therapy in People at Clinical High Risk of First Episode Psychosis].
abstract: OBJECTIVE
  Investigate whether treatment response in people at clinical high risk of psychosis (CHR) is predicted by their cognitive performance.
  
  
  METHODS
  128 CHR outpatients were randomized into two treatment groups, one receiving integrated psychological intervention (IPI), including psychoeducation, the other receiving supportive counselling (SC) for 12 months. Multiple regression analysis was used to identify neurocognitive predictors of treatment response in a subgroup of n = 105, measured by symptomatic and functional improvement at 1-year follow-up.
  
  
  RESULTS
  In the IPI, treatment response was associated with performance of executive control and processing speed (R² = 0.27, p = 0.002). In both treatment groups, performance of working memory/attention was a significant predictor (IPI: R² = 0.15, p = 0.039, SC: R² = 0.19, p = 0.012).
  
  
  CONCLUSIONS
  Cognitive performance is associated with treatment response in CHR people. The enhancement of cognitive performance is a useful target of early intervention.
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinik Köln.
authors: Helen
authors: H
authors: Wessels
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Bonn.
authors: Michael
authors: M
authors: Wagner
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Bonn.
authors: Ingo
authors: I
authors: Frommann
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Bonn.
authors: Julia
authors: J
authors: Berning
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinik Köln.
authors: Verena
authors: V
authors: Pützfeld
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf.
authors: Birgit
authors: B
authors: Janssen
authors: Klinik für Psychiatrie und Psychotherapie, Klinikum Lüdenscheid.
authors: Ronald
authors: R
authors: Bottlender
authors: Zentralinstitut für seelische Gesundheit, Mannheim.
authors: Kurt
authors: K
authors: Maurer
authors: Klinik für Psychiatrie und Psychotherapie, Ludwig-Maximilians-Universität München.
authors: Hans-Jürgen
authors: HJ
authors: Möller
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf.
authors: Wolfgang
authors: W
authors: Gaebel
authors: Zentralinstitut für seelische Gesundheit, Mannheim.
authors: Heinz
authors: H
authors: Häfner
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Bonn.
authors: Wolfgang
authors: W
authors: Maier
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinik Köln.
authors: Joachim
authors: J
authors: Klosterkötter
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinik Köln.
authors: Andreas
authors: A
authors: Bechdolf
mesh_terms: D000328:Adult; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003376:Counseling; D056344:Executive Function; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010353:Patient Education as Topic / Q000379:methods*; D011446:Prospective Studies; D011613:Psychotherapy / Q000379:methods*; D011618:Psychotic Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D011930:Reaction Time; D012306:Risk; D012559:Schizophrenia / Q000175:diagnosis / Q000628:therapy*; D012565:Schizophrenic Psychology; D012944:Social Support; D016896:Treatment Outcome; D055815:Young Adult