title: Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts.
abstract: BACKGROUND
  Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration for the treatment of warts.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of intralesional vitamin D treatment for plantar warts.
  
  
  METHODS
  Twenty patients with single or multiple plantar warts were included in this study. Vitamin D(3) (0.2 mL, 7.5 mg/mL) was injected into the base of the warts after prilocaine (0.1 mL, 20 mg/mL) injection. A maximum of 5 warts were treated in 1 session, with at maximum 2 injections performed at 4-week intervals.
  
  
  RESULTS
  In total, 16 of 20 patients (80%) showed complete resolution of warts, and 1 patient showed partial resolution. Three patients failed to show any response. No recurrence or serious adverse effects were observed.
  
  
  CONCLUSIONS
  Intralesional vitamin D(3) may be an effective treatment option for warts.
authors: Department of Dermatology, Education and Research Hospital, Karabük University, Karabük, Turkey.
authors: Habibullah
authors: H
authors: Aktaş
authors: Department of Dermatology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey drcanergin@hotmail.com.
authors: Can
authors: C
authors: Ergin
authors: Department of Dermatology, Fırat University Hospital, Elazığ, Turkey.
authors: Betül
authors: B
authors: Demir
authors: Department of Dermatology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors: Özlem
authors: Ö
authors: Ekiz
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage; D014860:Warts / Q000175:diagnosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D014815:Vitamins; D014807:Vitamin D
keywords: treatment; viral warts; vitamin D injection