title: Five potential therapeutic agents as antidepressants: a brief review and future directions.
abstract: Despite the availability of numerous antidepressants, many patients with depression do not show adequate response. The therapeutic lag between drug administration and onset of clinical improvement observed with conventional antidepressants has led to a need for antidepressants with a novel mechanism of action. Recently, five such agents, including acetyl-L-carnitine, scopolamine, ω-3 polyunsaturated fatty acids, ketamine, and selective 5-HT7 serotonin receptor antagonists, have gained interest as potential antidepressants with enhanced symptom control, improved tolerability, and faster onset of action compared to conventional antidepressants. This review provides an update and critical examination of these five novel therapeutic agents as potential antidepressants.
authors: a 1 Department of Psychiatry, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Sheng-Min
authors: SM
authors: Wang
authors: Changsu
authors: C
authors: Han
authors: Soo-Jung
authors: SJ
authors: Lee
authors: Ashwin A
authors: AA
authors: Patkar
authors: Prakash S
authors: PS
authors: Masand
authors: Chi-Un
authors: CU
authors: Pae
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D006801:Humans
chemical_list: D000928:Antidepressive Agents
keywords: acetyl-L-carnitine; depression; ketamine; novel mechanism; scopolamine; selective 5-HT7 serotonin receptor antagonist; ω-3 polyunsaturated fatty acids