title: Validation of a method for combining biplanar radiography and magnetic resonance imaging to estimate knee cartilage contact.
abstract: Combining accurate bone kinematics data from biplane radiography with cartilage models from magnetic resonance imaging, it is possible to estimate tibiofemoral cartilage contact area and centroid location. Proper validation of such estimates, however, has not been performed under loading conditions approximating functional tasks, such as gait, squatting, and stair descent. The goal of this study was to perform an in vitro validation to resolve the accuracy of cartilage contact estimations in comparison to a laser scanning gold standard. Results demonstrated acceptable reliability and accuracy for both contact area and centroid location estimates. Root mean square errors in contact area averaged 8.4% and 4.4% of the medial and lateral compartmental areas, respectively. Modified Sorensen-Dice agreement scores of contact regions averaged 0.81 ± 0.07 for medial and 0.83 ± 0.07 for lateral compartments. These validated methods have applications for in vivo assessment of a variety of patient populations and physical activities, and may lead to greater understanding of the relationships between knee cartilage function, effects of joint injury and treatment, and the development of osteoarthritis.
authors: Biodynamics Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, 3820 South Water Street, Pittsburgh, PA 15203, United States of America.
authors: Eric
authors: E
authors: Thorhauer
authors: Biodynamics Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, 3820 South Water Street, Pittsburgh, PA 15203, United States of America. Electronic address: tashman@pitt.edu.
authors: Scott
authors: S
authors: Tashman
mesh_terms: D000066949:Biobehavioral Sciences; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000000981:diagnostic imaging* / Q000502:physiology; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000502:physiology; D007834:Lasers; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D012984:Software; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016474:Weight-Bearing
keywords: Biplane radiography; Cartilage contact; Validation; knee biomechanics