title: Current Status and Prospects for a Helicobacter pylori Vaccine.
abstract: Helicobacter pylori infection contributes to a variety of gastric diseases. H pylori-associated gastric cancer is diagnosed in advanced stages, and a vaccine against H pylori is desirable in parts of the world where gastric cancer remains a common form of cancer. Some of the strategies of vaccine development used in animals have been tested in several phase 3 clinical trials; these trials have been largely unsuccessful, although H pylori-specific immune responses have been induced. New insights into promoting immunity and overcoming the immunosuppressive nature of H pylori infection are required to improve the efficacy of an H pylori vaccine.
authors: Department of Pediatrics, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA. Electronic address: tblanchard@peds.umaryland.edu.
authors: Thomas G
authors: TG
authors: Blanchard
authors: Department of Pediatrics, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA.
authors: Steven J
authors: SJ
authors: Czinn
mesh_terms: D001428:Bacterial Vaccines; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D016480:Helicobacter pylori; D006801:Humans; D013274:Stomach Neoplasms / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D001428:Bacterial Vaccines
keywords: Cancer; Clinical trials; Helicobacter pylori; Inflammation; Vaccine