title: The many ways to make a luminal cell and a prostate cancer cell.
abstract: Research in the area of stem/progenitor cells has led to the identification of multiple stem-like cell populations implicated in prostate homeostasis and cancer initiation. Given that there are multiple cells that can regenerate prostatic tissue and give rise to prostate cancer, our focus should shift to defining the signaling mechanisms that drive differentiation and progenitor self-renewal. In this article, we will review the literature, present the evidence and raise important unanswered questions that will help guide the field forward in dissecting critical mechanisms regulating stem-cell differentiation and tumor initiation.
authors: Department of UrologyUniversity of Texas Southwestern, Dallas, Texas, USADepartment of Molecular and Medical PharmacologyDepartment of Urology, David Geffen School of Medicine, Broad Stem Cell Research Center, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.
authors: Douglas W
authors: DW
authors: Strand
authors: Department of UrologyUniversity of Texas Southwestern, Dallas, Texas, USADepartment of Molecular and Medical PharmacologyDepartment of Urology, David Geffen School of Medicine, Broad Stem Cell Research Center, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA AGoldstein@mednet.ucla.edu.
authors: Andrew S
authors: AS
authors: Goldstein
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology*; D000728:Androgens; D000818:Animals; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D019070:Cell Lineage; D000066673:Cell Self Renewal; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004848:Epithelium / Q000473:pathology*; D006706:Homeostasis; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051379:Mice; D023421:Models, Animal; D008954:Models, Biological; D039902:Multipotent Stem Cells / Q000166:cytology; D009363:Neoplasm Proteins / Q000502:physiology; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000166:cytology*; D009919:Orchiectomy; D019899:Paracrine Communication; D011467:Prostate / Q000166:cytology*; D011470:Prostatic Hyperplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000209:etiology / Q000473:pathology*; D011944:Receptors, Androgen / Q000502:physiology; D015398:Signal Transduction; D055153:Stem Cell Niche; D017154:Stromal Cells / Q000502:physiology
chemical_list: D000728:Androgens; D009363:Neoplasm Proteins; D011944:Receptors, Androgen
keywords: carcinoma; prostate