title: Remodeling Amyloid Fibers: Baker's Yeast Shows Us the Way.
abstract: Proteopathies are a large and diverse group of human diseases that are caused by protein misfolding. Well-known examples of proteopathies are Alzheimer's and Parkinson's disease, which are both linked to amyloid fibril formation. In this issue of Chemistry & Biology, Castellano et al. (2015) describe the way to harness the power of a protein from baker's yeast, Hsp104, to disaggregate the fibrils.
authors: Neurophage Pharmaceuticals, 222 Third Street, Suite 3120, Cambridge, MA 02142, USA.
authors: Eva
authors: E
authors: Asp
authors: Neurophage Pharmaceuticals, 222 Third Street, Suite 3120, Cambridge, MA 02142, USA.
authors: Ming
authors: M
authors: Proschitsky
authors: Neurophage Pharmaceuticals, 222 Third Street, Suite 3120, Cambridge, MA 02142, USA. Electronic address: rkrishnan@neurophage.com.
authors: Rajaraman
authors: R
authors: Krishnan
mesh_terms: D000682:Amyloid / Q000037:antagonists & inhibitors*; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006360:Heat-Shock Proteins / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000682:Amyloid; D019380:Anti-HIV Agents; D006360:Heat-Shock Proteins; D010446:Peptide Fragments; D029701:Saccharomyces cerevisiae Proteins