title: Severe Darier's disease in a psychiatric patient.
abstract: Darier's disease is characterized by dense keratotic lesions in the seborrheic areas of the body such as scalp, forehead, nasolabial folds, trunk and inguinal region. It is a rare genodermatosis, an autosomal dominant inherited disease that may be associated with neuropsichiatric disorders. It is caused by ATPA2 gene mutation, presenting cutaneous and dermatologic expressions. Psychiatric symptoms are depression, suicidal attempts, and bipolar affective disorder. We report a case of Darier's disease in a 48-year-old female patient presenting severe cutaneous and psychiatric manifestations.
authors: Complexo Hospitalar Padre Bento de Guarulhos, São Paulo, SP, BR.
authors: Jeane Jeong Hoon
authors: JJ
authors: Yang
authors: Complexo Hospitalar Heliópolis, Heliópolis, SP, BR.
authors: Roberta Simão
authors: RS
authors: Lopes
authors: Hospital Stella Maris, Guarulhos, SP, BR.
authors: Medéia Carolina Fernandes
authors: MC
authors: Pereira
authors: Complexo Hospitalar Padre Bento de Guarulhos, São Paulo, SP, BR.
authors: Antonio Jose
authors: AJ
authors: Tebcherani
authors: Complexo Hospitalar Padre Bento de Guarulhos, São Paulo, SP, BR.
authors: Mário Cezar
authors: MC
authors: Pires
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics; D007644:Darier Disease / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology*