title: 3D interslab echo-shifted FLASH sequence for susceptibility weighted imaging.
abstract: To develop a novel three-dimensional (3D) sequence for susceptibility weighted imaging that is able to reduce scan time substantially while maintaining high image signal-to-noise ratio (SNR).
  
  
  
  The proposed fast T2 *-weighted sequence was based on a 3D full-balanced gradient frame and a pair of crusher gradients. The pair of crusher gradients were used to shift MR signal from the repetition time where the MR signal was originated to a later repetition time to enhance T2 * weighting. To avoid image SNR reduction due to the repeated signal excitations by later RF pulses, as it would occur for typical echo-shifted (ES) FLASH, an interslab scan mode for the fast T2 *-weighted sequence was introduced for signal acquisition. The effectiveness of this novel sequence was evaluated by comparing it with 3D FLASH and ES-FLASH sequences.
  
  
  
  The proposed interslab ES T2 *-weighted sequence was able to reduce the scan time by half with a SNR comparable to the typical multislab FLASH. Besides, it yielded a higher image SNR than the traditional multislab ES-FLASH and was more flexible than the whole-volume ES-FLASH.
  
  
  
  An interslab ES sequence was developed with high time efficiency and relatively high image SNR compared with the conventional acquisition sequences. Magn Reson Med 76:222-228, 2016. © 2015 Wiley Periodicals, Inc.
authors: Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.|Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
authors: Ya-Jun
authors: YJ
authors: Ma
authors: Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.|Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
authors: Wentao
authors: W
authors: Liu
authors: Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.|Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
authors: Xuna
authors: X
authors: Zhao
authors: Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.|Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
authors: Weinan
authors: W
authors: Tang
authors: Department of Biomedical Engineering, Dalian University of Technology, Dalian, China.
authors: Huanjie
authors: H
authors: Li
authors: Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.|Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
authors: Yang
authors: Y
authors: Fan
authors: Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.|Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
authors: Xin
authors: X
authors: Tang
authors: Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.|Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
authors: Yaoyu
authors: Y
authors: Zhang
authors: Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.|Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.|McGovern Institute for Brain Research, Peking University, Beijing, China.
authors: Jia-Hong
authors: JH
authors: Gao
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio
keywords: echo shifting; fast T2*-weighted sequence; interslab scan mode