title: Hereditary Colorectal Cancer: Genetics and Screening.
abstract: Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.
authors: Department of Pathology, University Medical Center Utrecht (H04-312), Heidelberglaan 100, Utrecht 3584 CX, The Netherlands; Department of Pathology, The Johns Hopkins University School of Medicine, CRB 2, Room 345, 1550 Orleans Street, Baltimore, MD 21231, USA. Electronic address: l.a.a.brosens@umcutrecht.nl.
authors: Lodewijk A A
authors: LA
authors: Brosens
authors: Department of Pathology, University Medical Center Utrecht (H04-312), Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
authors: G Johan A
authors: GJ
authors: Offerhaus
authors: Department of Medicine, Oncology Center, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 431, Baltimore, MD 21205, USA; Department of Pathology, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 431, Baltimore, MD 21205, USA. Electronic address: fgiardi@jhmi.edu.
authors: Francis M
authors: FM
authors: Giardiello
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D014408:Biomarkers, Tumor / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D055088:Early Detection of Cancer; D020022:Genetic Predisposition to Disease; D006801:Humans
chemical_list: D014408:Biomarkers, Tumor
keywords: Colorectal cancer; Familial adenomatous polyposis; Hereditary nonpolyposis colorectal cancer; Lynch syndrome; MUTYH-associated polyposis