title: Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light.
abstract: Trans diiodido platinum(II) complexes bearing the same as well as different aliphatic amines (mixed-amines) have interesting biological activity; cytotoxicity and interactions with some important biological models have already been demonstrated. Herein we described the interaction of such compounds with ct-DNA, supercoiled and linearized plasmid DNA and 5-GMP. Interestingly, UV irradiation of these compounds results in an increase in reactivity towards DNA and 5-GMP in such model systems. Additionally, the cytotoxicity of the trans-Pt(II) complexes towards human cancer cells is noticeably increased when treatment is combined for 90min with UVA-irradiation. With this work we provide evidence that trans diiodido compounds can be activated by UV-light over relatively short treatment times.
authors: Departamento de Química Inorgánica, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente, 28049 Madrid, Spain.
authors: Francisco
authors: F
authors: Navas
authors: Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald, 17487 Greifswald, Germany.
authors: Stefanie
authors: S
authors: Perfahl
authors: Department of Chemistry and NIS, Center of Excellence, University of Turin, via Pietro Giuria 7, 10125 Turin, Italy.
authors: Claudio
authors: C
authors: Garino
authors: CIC biomaGUNE, Paseo de Miramón 182, 20009 Donostia, Spain.
authors: Luca
authors: L
authors: Salassa
authors: Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Královopolská 135, CZ-61265 Brno, Czech Republic.
authors: Olga
authors: O
authors: Novakova
authors: Departamento de Química Inorgánica, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente, 28049 Madrid, Spain.
authors: Carmen
authors: C
authors: Navarro-Ranninger
authors: Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald, 17487 Greifswald, Germany.
authors: Patrick J
authors: PJ
authors: Bednarski
authors: Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Královopolská 135, CZ-61265 Brno, Czech Republic.
authors: Jaroslav
authors: J
authors: Malina
authors: Departamento de Química Inorgánica, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente, 28049 Madrid, Spain.
authors: Adoración G
authors: AG
authors: Quiroga
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000528:radiation effects* / Q000633:toxicity; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D006801:Humans; D007454:Iodides / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000528:radiation effects* / Q000633:toxicity; D014466:Ultraviolet Rays
chemical_list: D000970:Antineoplastic Agents; D007454:Iodides; D009944:Organoplatinum Compounds; D004247:DNA
keywords: DNA interactions; Metallodrug photoactivaton; Platinum drugs