title: Synthesis of Hindered α-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds.
abstract: The synthesis of sterically hindered anilines has been a significant challenge in organic chemistry. Here we report a Cu-catalyzed radical addition with in situ-generated nitroso compounds to prepare sterically hindered amines directly from readily available materials. The transformation is conducted at room temperature, uses abundant copper salts, and is tolerant of a range of functional groups.
authors: Department of Chemistry & Biochemistry, University of California , Santa Barbara, California 93106, United States.
authors: David J
authors: DJ
authors: Fisher
authors: Department of Chemistry & Biochemistry, University of California , Santa Barbara, California 93106, United States.
authors: G Leslie
authors: GL
authors: Burnett
authors: Department of Chemistry & Biochemistry, University of California , Santa Barbara, California 93106, United States.
authors: Rocío
authors: R
authors: Velasco
authors: Department of Chemistry & Biochemistry, University of California , Santa Barbara, California 93106, United States.
authors: Javier
authors: J
authors: Read de Alaniz
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009603:Nitroso Compounds / Q000737:chemistry*
chemical_list: D007659:Ketones; D009603:Nitroso Compounds; D003300:Copper