title: Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice.
abstract: Immunosenescence contributes to pathogenesis of Alzheimer's disease (AD) in the elderly. In this study, we explored the effects of young wild type (WT) splenocytes (ySCs) on Alzheimer's disease by transplanting ySCs into APPswe/PSENldE9 transgenic mice. Young WT splenocytes not only prevented AD, but also improved the spatial learning and memory of APPswe/PSENldE9 transgenic mice. Young WT splenocytes enhanced Aβ clearance, decreased astrogliosis and increased systemic growth differentiation factor 11 (GDF11) levels. Splenocytes derived from old AD mouse promoted AD. There was an increased number of regulatory T cells (Tregs) among old AD splenocytes. We suggest that alterations of GDF11 and Tregs are involved in AD progression and that rejuvenation of the immune system is a potential therapeutic strategy in AD.
authors: Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
authors: Fei
authors: F
authors: Wang
authors: Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
authors: Xueyan
authors: X
authors: Shen
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P. R. China.|Department of Radiology, PLA No. 455 Hospital, Shanghai, P. R. China.
authors: Shuping
authors: S
authors: Li
authors: Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
authors: Long
authors: L
authors: Chen
authors: Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
authors: Yanru
authors: Y
authors: Wang
authors: Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
authors: Jie
authors: J
authors: Qin
authors: Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
authors: Guomin
authors: G
authors: Zhou
authors: Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
authors: Yuwen
authors: Y
authors: Peng
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P. R. China.
authors: Xiaoyuan
authors: X
authors: Feng
authors: Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
authors: Ruixi
authors: R
authors: Li
authors: Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China.
authors: Chunmin
authors: C
authors: Liang
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D000818:Animals; D001253:Astrocytes / Q000166:cytology; D001522:Behavior, Animal; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D017690:Cell Transplantation; D004195:Disease Models, Animal; D018450:Disease Progression; D005091:Exons; D055412:Growth Differentiation Factors / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D000068884:Immunosenescence; D008297:Male; D018782:Maze Learning; D051379:Mice; D008822:Mice, Transgenic; D017628:Microglia / Q000378:metabolism; D053764:Presenilin-1 / Q000235:genetics; D065853:Spatial Learning; D013154:Spleen / Q000166:cytology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology
chemical_list: D019485:Bone Morphogenetic Proteins; C119153:Gdf11 protein, mouse; D055412:Growth Differentiation Factors; D053764:Presenilin-1
keywords: Alzheimer’s disease; GDF11; Gerotarget; Treg; immunosenescence; splenocytes