title: Undifferentiated Laryngeal Carcinoma with Pagetoid Spread.
abstract: Pagetoid spread, is used to define intraepithelial spread of cancer cells, when a massive carcinoma is identified beneath the basal membrane. There are only few reports of pagetoid spread at the head and neck region. Herein a 74 year old male patient with bilateral transglottic laryngeal high grade malignant epithelial tumor with pagetoid spread is presented. The tumor was located at the submucosa and there was spread of the CK7 and CK19 positive tumor cells into the non neoplastic mucosa, which was CK5/6 positive, sparing the basement membrane, creating a typical pagetoid pattern. Radiographic and positron emission tomography scan examination of the patient was unremarkable at presentation other than the laryngeal and neck lesions; but extensive systemic metastasis developed at 6 months following operation. To the best of our knowledge no epithelial malignancy with pagetoid spread was described at the larynx. Pagetoid spread may be a hallmark of very aggressive behavior in laryngeal carcinoma.
authors: Department of Pathology, Faculty of Medicine, Dokuz Eylul University, 35340, Inciralti, Izmir, Turkey. sulen.sarioglu@deu.edu.tr.
authors: Sulen
authors: http://orcid.org/0000-0003-4877-3064
authors: S
authors: Sarioglu
authors: Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey.
authors: Ersoy
authors: E
authors: Dogan
authors: Department of Pathology, Faculty of Medicine, Dokuz Eylul University, 35340, Inciralti, Izmir, Turkey.
authors: Yasemin
authors: Y
authors: Sahin
authors: Department of Pathology, Faculty of Medicine, Dokuz Eylul University, 35340, Inciralti, Izmir, Turkey.
authors: Evren
authors: E
authors: Uzun
authors: Department of Nuclear Medicine, Faculty of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey.
authors: Recep
authors: R
authors: Bekis
authors: Department of Radiodiagnostics, Faculty of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey.
authors: Emel
authors: E
authors: Ada
authors: Department of Pathology, Faculty of Medicine, Dokuz Eylul University, 35340, Inciralti, Izmir, Turkey.
authors: Ozgul
authors: O
authors: Sagol
authors: Department of Radiation Oncology, Faculty of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey.
authors: Fadime
authors: F
authors: Akman
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D009362:Neoplasm Metastasis / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Aggressive behavior; Larynx; Pagetoid spread; Undifferentiated carcinoma