title: New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes.
abstract: A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.
authors: Dorothy M. Davis Heart & Lung Research Institute, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United States.
authors: Ilirian
authors: I
authors: Dhimitruka
authors: Department of Microbiology, Immunology, and Cell Biology, West Virginia University Health Sciences, Morgantown, VW 26506, United States.
authors: Timothy D
authors: TD
authors: Eubank
authors: Dorothy M. Davis Heart & Lung Research Institute, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United States.
authors: Amy C
authors: AC
authors: Gross
authors: Dorothy M. Davis Heart & Lung Research Institute, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United States.
authors: Valery V
authors: VV
authors: Khramtsov
mesh_terms: D001375:Azaguanine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D007624:KB Cells; D018613:Microscopy, Confocal; D015394:Molecular Structure
chemical_list: D005456:Fluorescent Dyes; D001375:Azaguanine
keywords: 2,4-Diamino-6-hydroxypyrimidine; 8-Aryl-7-deazaguanine; Cellular permeability; Fluorescent probes; Phenacyl bromides