title: [STUDYING ACUTE TOXICITY OF NEW RADIOPHARMACEUTICAL 99MTC-AL2O3 NANOCOLLOIDS FOR ONCOLOGICAL DIAGNOSTICS].
abstract: The acute toxicity of a new drug based on nanocolloidal gamma alumina labeled with technetium-99m (99mTc) has been studied on 80 rats (40 females and 40 males) and 80 mice (40 females and 40 males) with intraperitoneal and subcutaneous drug administration. A single administration of the pharmacological agent was followed by observation of the survival of animals for 14 days with determining tolerable, toxic, and lethal doses for intraperitoneal and subcutaneous administration according to the Litchfield - Wilcoxon method, establishing the causes of animal death within 14 days of observation, and studying the drug influence on the general condition and some functional and morphological indices. Based on the established boundaries of toxicity and the classification of toxicity, the 99mTc-Al2O3 nanocolloids can be classified into conditionally moderately toxic substances. The actual values of LD5 of the radiopharmaceutical fall in the range of large doses. The safety factor for the drug studied significantly exceeds the minimum permissible value of 100.
authors: N V
authors: NV
authors: Varlamova
authors: V S
authors: VS
authors: Skuridin
authors: E A
authors: EA
authors: Nesterov
authors: V I
authors: VI
authors: Chernov
authors: A A
authors: AA
authors: Titskaya
mesh_terms: D000537:Aluminum Oxide / Q000009:adverse effects* / Q000494:pharmacology; D000818:Animals; D003102:Colloids; D004341:Drug Evaluation; D005260:Female; D008297:Male; D051379:Mice; D053758:Nanoparticles; D009369:Neoplasms / Q000175:diagnosis*; D019275:Radiopharmaceuticals / Q000009:adverse effects* / Q000494:pharmacology; D051381:Rats; D013667:Technetium / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D003102:Colloids; D019275:Radiopharmaceuticals; D013667:Technetium; D000537:Aluminum Oxide