title: Optical Coherence Tomography Imaging of Normal, Chronologically Aged, Photoaged and Photodamaged Skin: A Systematic Review.
abstract: BACKGROUND
  Optical coherence tomography (OCT) is capable of providing a noninvasive real-time cross-sectional image of the skin through light-based interferometry, a method sometimes described as "light-based ultrasound." One key application of OCT in dermatology is the visualization of dermal collagen during chronological aging, photoaging, or photodamage. These skin conditions are typically managed by the practitioner's subjective assessment of severity and response to therapy.
  
  
  OBJECTIVE
  The purpose of this review is to present available evidence on the ability of OCT to image normal, chronologically aged, photoaged and photodamaged skin in human subjects.
  
  
  METHODS
  The authors have searched Medline, PubMed, EMBASE, Web of Science, Google Scholar, and Cochrane Library databases for published literature on the imaging of skin collagen by OCT using the following search terms: "optical coherence tomography," "OCT," "skin," "collagen," "photoaging," "wrinkles," and "photodamage."
  
  
  RESULTS
  The search resulted in 23 articles investigating OCT-based skin collagen imaging, which met their search criteria.
  
  
  CONCLUSIONS
  The authors anticipate tremendous growth in the field of OCT-based skin imaging that will parallel the development ultrasound technology has experienced over the past 30 years. They foresee that the use of OCT imaging to evaluate skin aging will not only help identify pathological changes earlier, but will also assist in the evaluation of the response to therapy longitudinally without biopsy.
authors: *Department of Dermatology, University of California, Davis, Sacramento, California; †Dermatology Service, Sacramento VA Medical Center, Mather, California; ‡Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York.
authors: Andrew
authors: A
authors: Mamalis
authors: Derek
authors: D
authors: Ho
authors: Jared
authors: J
authors: Jagdeo
mesh_terms: D003880:Dermatology / Q000379:methods*; D006801:Humans; D015595:Skin Aging; D012871:Skin Diseases / Q000175:diagnosis*; D041623:Tomography, Optical Coherence