title: Factors implicated in the initiation of human parturition in term and preterm labor: a review.
abstract: After accommodating the pregnancy for an average of 40 weeks, the uterus expels the fetus, the placenta and the membranes through the birth canal in a process named parturition. The absolute sequence of events that trigger and sustain human parturition are not yet fully clarified. Evidence suggests that spontaneous preterm and term labor seem to share a common inflammatory pathway. However, there are several other factors being involved in the initiation of human parturition. Placental corticotropin releasing hormone production seems to serve as a placental clock that might be set to ring earlier or later determining the duration of pregnancy and timing of labor. Estrogens do not cause contractions but their properties seem to capacitate uterus to coordinate and enhance contractions. Cytokines, prostaglandins, nitric oxide and steroids seem also to induce ripening by mediating remodeling of the extracellular matrix and collagen. Infection and microbe invasion resulting in chorioamnionitis also represents a common cause of early preterm labour. This review provides an overview of all these factors considered to be implicated in the initiation of human parturition.
authors: a IAKENTRO, Infertility Treatment Center , Thessaloniki , Greece.
authors: Konstantinos
authors: K
authors: Ravanos
authors: a IAKENTRO, Infertility Treatment Center , Thessaloniki , Greece.
authors: Themistoklis
authors: T
authors: Dagklis
authors: a IAKENTRO, Infertility Treatment Center , Thessaloniki , Greece.
authors: Stamatios
authors: S
authors: Petousis
authors: a IAKENTRO, Infertility Treatment Center , Thessaloniki , Greece.
authors: Chrysoula
authors: C
authors: Margioula-Siarkou
authors: a IAKENTRO, Infertility Treatment Center , Thessaloniki , Greece.
authors: Yannis
authors: Y
authors: Prapas
authors: a IAKENTRO, Infertility Treatment Center , Thessaloniki , Greece.
authors: Nikolaos
authors: N
authors: Prapas
mesh_terms: D020070:Cervical Ripening / Q000378:metabolism; D002821:Chorioamnionitis / Q000378:metabolism / Q000503:physiopathology; D003094:Collagen / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000378:metabolism* / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism*; D007752:Obstetric Labor, Premature / Q000378:metabolism* / Q000503:physiopathology; D036801:Parturition / Q000378:metabolism* / Q000502:physiology; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011453:Prostaglandins / Q000378:metabolism*; D014590:Uterine Contraction / Q000378:metabolism / Q000502:physiology
chemical_list: D016207:Cytokines; D004967:Estrogens; D011453:Prostaglandins; D009569:Nitric Oxide; D003094:Collagen; D003346:Corticotropin-Releasing Hormone
keywords: Androgens; estrogens; hypothalamus; pregnancy