title: Screening for Subclinical Keratoconus Using Swept-Source Fourier Domain Anterior Segment Optical Coherence Tomography.
abstract: OBJECTIVE
  To discriminate between subclinical fellow eyes of patients with keratoconus (scKCE) and normal eyes (NE) using swept-source Fourier-domain anterior segment optical coherence tomography (SS-OCT).
  
  
  METHODS
  University Medical Center Hamburg-Eppendorf, Germany.
  
  
  METHODS
  Retrospective cross-sectional study.
  
  
  METHODS
  NE (both eyes with a KISA% Index <60; N = 213) and scKCE (KISA% Index <60, but an index of >100 in the fellow eye; N = 61) eyes were grouped according to the KISA% Index. Topography and tomography data were obtained by SS-OCT (Casia SS1000) and reviewed retrospectively. Receiver operating characteristics were performed for Casia SS1000 integrated automated parameters and newly computed indices. Additionally, discriminant functions were calculated for the automated single parameters, the computed indices, and the combination of both.
  
  
  RESULTS
  An accuracy ≥0.7 was reached for 28 (8 automated and 20 newly computed parameters) of 785 parameters. Fourier analysis posterior higher-order irregular astigmatism revealed the highest accuracy with 0.81. By combining automated parameters with the newly computed indices in 1 discriminant function, an area under the curve of 0.92 with a corresponding accuracy of 0.85 was achieved.
  
  
  CONCLUSIONS
  SS-OCT is able to discriminate between NE and scKCE with high accuracy. Automated single parameters and newly computed indices were combined to further improve this accuracy.
authors: *Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; †Zentrumsehstärke, Hamburg, Germany; and ‡CareVision, Hamburg, Germany.
authors: Johannes
authors: J
authors: Steinberg
authors: Maria K
authors: MK
authors: Casagrande
authors: Andreas
authors: A
authors: Frings
authors: Toam
authors: T
authors: Katz
authors: Vasyl
authors: V
authors: Druchkiv
authors: Gisbert
authors: G
authors: Richard
authors: Stephan J
authors: SJ
authors: Linke
mesh_terms: D000328:Adult; D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography; D003430:Cross-Sectional Studies; D005260:Female; D005583:Fourier Analysis; D064368:Healthy Volunteers; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis*; D008297:Male; D012372:ROC Curve; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult