title: Toxicity of zinc oxide nanoparticles on adult male Wistar rats.
abstract: The purpose of this study was to investigate the effects of zinc oxide nanoparticles (nZnO) on adult male Wistar rats. Thirty male Wistar rats divided into five groups of six animals each were used for this study. For ten days, Groups one to four continuously received 50, 100, 150 and 200 mg/kg nZnO, respectively. Group five served as the control group. At the end of the study, the rats were sacrificed and histopathological study of the liver and renal tissue, sperm analysis, serum oxidative stress parameters and some liver enzymes were done. The results of this study showed that nZnO at concentration more than 50 mg/kg lead to significant changes in liver enzymes, oxidative stress, liver and renal tissue and sperm quality and quantity. In conclusion, the toxicity of nZnO is more significant when the concentration is increased; however, the use of low doses requires further investigation.
authors: Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: abbasalipourkabir@yahoo.com.
authors: Roghayeh
authors: R
authors: Abbasalipourkabir
authors: Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors: Hemen
authors: H
authors: Moradi
authors: Department of Clinical Biochemistry, School of Medicine, Yazd University of Medical Sciences, Yazd, Iran.
authors: Sadegh
authors: S
authors: Zarei
authors: Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors: Soheila
authors: S
authors: Asadi
authors: Department of Entomology and Toxicology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors: Aref
authors: A
authors: Salehzadeh
authors: Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
authors: Abolfazl
authors: A
authors: Ghafourikhosroshahi
authors: Department of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors: Motahareh
authors: M
authors: Mortazavi
authors: Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors: Nasrin
authors: N
authors: Ziamajidi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000633:toxicity* / Q000648:ultrastructure; D009393:Nephritis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009845:Oligospermia / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism; D017208:Rats, Wistar; D055101:Semen Analysis; D014018:Tissue Distribution; D059551:Toxicity Tests, Subacute; D066007:Toxicokinetics; D015034:Zinc Oxide / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D010088:Oxidoreductases; D015034:Zinc Oxide
keywords: Histopathology; Liver enzyme; Oxidative stress system; Sperm analysis; ZnO nanoparticles