title: [To treat or not to treat asymptomatic bacteriuria before methylprednisolone perfusion].
abstract: The prescription of methylprednisolone for multiple sclerosis acute relapse involves sterilization of urine. An observational study was conducted to clarify the benefit of antibiotic prophylaxis in case of asymptomatic bacteriuria found before methylprednisolone. Ninety-seven patients were included; 32 patients had asymptomatic bacteriuria. Seventeen patients were treated and 15 were not. The number of urinary tract infections in the month following the methylprednisolone was the same in the two groups. The results seem in favor of a therapeutic abstention. A larger study will be performed to confirm these results and determine appropriate recommendations.
authors: Service de médecine physique et réadaptation fonctionnelle, groupement hospitalier de l'institut catholique de Lille, rue du Grand-But, BP 249, 59462 Lomme cedex, France. Electronic address: donze.cecile@ghicl.net.
authors: C
authors: C
authors: Donzé
authors: Unité des maladies infectieuses, hôpital Raymond-Poincaré, 104, boulevard Raymond-Poincaré, 92380 Garches, France.
authors: A
authors: A
authors: Dinh
authors: Service de neurologie, CHI de Poissy/Saint-Germain-en-Laye, CS 73082, 78303 Poissy cedex, France.
authors: O
authors: O
authors: Heinzlef
authors: Service de neurologie, groupement hospitalier de l'institut catholique de Lille, rue du Grand-But, BP 249, 59462 Lomme cedex, France.
authors: P
authors: P
authors: Hautecoeur
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000706:statistics & numerical data*; D058070:Asymptomatic Diseases; D001437:Bacteriuria / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D018450:Disease Progression; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome; D019564:Unnecessary Procedures / Q000706:statistics & numerical data*; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D008776:Methylprednisolone Hemisuccinate
keywords: Asymptomatic bacteriuria; Bactériurie asymptomatique; Bolus de solumédrol; Bolus solumedrol; Examen cytobactériologique des urines; Multiple sclerosis; Sclérose en plaques; Urine culture