title: Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients.
abstract: BACKGROUND
  The role of specific IgE (sIgE) against Der p 1 and Der p 2 in Chinese patients with house dust mite (HDM) allergy has not yet been well investigated.
  
  
  METHODS
  One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity to Dermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP.
  
  
  RESULTS
  Almost all patients were sensitized to Der p 1 (95%) and Der p 2 (93%), with both allergens together being largely responsible for the total anti-HDM IgE response. No evidence for a significant role of Der p 10 was found. Overall, IgE responses to HDM and its 2 major allergens were higher in children than in adults in this cross-sectional study. With increasing age, IgE responses to Der p 2 become more important. A positive correlation was observed between the reaction of sIgE against Dp, Der p 1 and Der p 2 and the number of organs (including the eyes, nose, lungs and skin) that were affected in patients.
  
  
  CONCLUSIONS
  In China, Der p 1 and Der p 2 are the dominant allergens in patients with HDM allergy. The relative importance of Der p 1 and Der p 2 changes with age, in favor of Der p 2. Overall, sIgE titers were positively associated with the number of organs affected.
authors: Department of Allergy, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, PR China.
authors: Hui-Ying
authors: HY
authors: Wang
authors: Zhong-Shan
authors: ZS
authors: Gao
authors: Xiang
authors: X
authors: Zhou
authors: Yu
authors: Y
authors: Dai
authors: Wo
authors: W
authors: Yao
authors: Xiao-Feng
authors: XF
authors: Zhang
authors: Zhao-Wei
authors: ZW
authors: Yang
authors: Shan-Dong
authors: SD
authors: Wu
authors: Chao-Hui
authors: CH
authors: Yu
authors: Xu-Yan
authors: XY
authors: Yang
authors: Ronald
authors: R
authors: van Ree
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000485:Allergens / Q000276:immunology*; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D060829:Arthropod Proteins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003546:Cysteine Endopeptidases / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012882:Skin Tests; D055815:Young Adult
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D060829:Arthropod Proteins; C451163:Dermatophagoides pteronyssinus antigen p 2; D007073:Immunoglobulin E; D003546:Cysteine Endopeptidases; C451162:Dermatophagoides pteronyssinus antigen p 1