title: Calcitonin-negative neuroendocrine tumor of thyroid gland mimicking anaplastic carcinoma: an unusual entity.
abstract: Medullary thyroid cancer is the neuroendocrine tumor (NET) of thyroid with mostly both secreting calcitonin and immunohistochemically showing calcitonin positivity. Occasionally; NETs of thyroid may have little or no calcitonin expression. We present a case of serum calcitonin negative and immunohistochemically calcitonin-negative staining tumor with positive reaction to neuroendocrine markers synaptophysin and chromogranin-A. The patient's right vocal cord was paralytic and thyroid mass was huge with descending to thorax till hilar region. We discussed diagnostic difficulties and way of treatment about NETs of thyroid with the light of current literature with this case.
authors: 1 Department of Otorhinolaryngology, 2 Department of Pathology, Faculty of Medicine, 3 Department of General Surgery, 4 Department of Medical Oncology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors: Onur
authors: O
authors: Ismi
authors: 1 Department of Otorhinolaryngology, 2 Department of Pathology, Faculty of Medicine, 3 Department of General Surgery, 4 Department of Medical Oncology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors: Rabia Bozdogan
authors: RB
authors: Arpaci
authors: 1 Department of Otorhinolaryngology, 2 Department of Pathology, Faculty of Medicine, 3 Department of General Surgery, 4 Department of Medical Oncology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors: Mustafa
authors: M
authors: Berkesoglu
authors: 1 Department of Otorhinolaryngology, 2 Department of Pathology, Faculty of Medicine, 3 Department of General Surgery, 4 Department of Medical Oncology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors: Ahmet
authors: A
authors: Dag
authors: 1 Department of Otorhinolaryngology, 2 Department of Pathology, Faculty of Medicine, 3 Department of General Surgery, 4 Department of Medical Oncology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors: Emel
authors: E
authors: Sezer
authors: 1 Department of Otorhinolaryngology, 2 Department of Pathology, Faculty of Medicine, 3 Department of General Surgery, 4 Department of Medical Oncology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors: Kemal Koray
authors: KK
authors: Bal
authors: 1 Department of Otorhinolaryngology, 2 Department of Pathology, Faculty of Medicine, 3 Department of General Surgery, 4 Department of Medical Oncology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors: Yusuf
authors: Y
authors: Vayısoğlu
keywords: Neuroendocrine tumor (NET); calcitonin; medullary thyroid carcinoma (MTC); thyroid