title: Fetuin-A levels and free leptin index are reduced in patients with chronic lymphocytic leukemia: a hospital-based case-control study.
abstract: There are limited data on fetuin-A, soluble leptin receptor (sOB-R) and free leptin index (FLI) in patients with chronic lymphocytic leukemia (CLL). The aim of this study was to compare circulating fetuin-A, sOB-R levels and FLI between 95 patients with CLL and 95 matched controls, as well as among different stages of CLL. Circulating fetuin-A was significantly lower in cases than controls (241.9 ± 99.2 vs. 288.8 ± 127.7 μg/mL; p = 0.005). Although circulating sOB-R levels were similar between groups, FLI was lower in cases than controls (0.45 ± 0.42 vs. 0.67 ± 0.57; p = 0.003). Furthermore, lower fetuin-A or FLI, but not sOB-R, were independently associated with CLL (p < 0.05), particularly among overweight/obese individuals. Fetuin-A, s-OB-R and FLI were similar between different stages of CLL severity, or between symptomatic and asymptomatic disease. In conclusion, circulating fetuin-A and FLI, but not sOB-R, were lower in patients with CLL than controls, a finding warranting further investigation.
authors: a Department of Clinical Biochemistry, Medical School , University of Athens, "Attikon" General University Hospital , Athens , Greece .
authors: Maria
authors: M
authors: Dalamaga
authors: b Division of Endocrinology, Diabetes and Metabolism , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA .
authors: Stergios A
authors: SA
authors: Polyzos
authors: c Department of Internal Medicine , 417 Army Share Fund General Hospital , Athens , Greece .
authors: Konstantinos
authors: K
authors: Karmaniolas
authors: b Division of Endocrinology, Diabetes and Metabolism , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA .
authors: John
authors: J
authors: Chamberland
authors: d Hematology Laboratory , 417 Army Share Fund General Hospital , Athens , Greece .
authors: Antigoni
authors: A
authors: Lekka
authors: d Hematology Laboratory , 417 Army Share Fund General Hospital , Athens , Greece .
authors: Maria
authors: M
authors: Triantafilli
authors: c Department of Internal Medicine , 417 Army Share Fund General Hospital , Athens , Greece .
authors: Ilias
authors: I
authors: Migdalis
authors: e Dermatology Clinic, Department of Internal Medicine, Medical School , University of Athens, "Attikon", General University Hospital , Athens , Greece , and.
authors: Evangelia
authors: E
authors: Papadavid
authors: b Division of Endocrinology, Diabetes and Metabolism , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA .|f Section of Endocrinology , Boston VA Healthcare System, Harvard Medical School , Boston , MA , USA.
authors: Christos S
authors: CS
authors: Mantzoros
mesh_terms: D000368:Aged; D015415:Biomarkers; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D011379:Prognosis; D012307:Risk Factors; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D020738:Leptin; D060749:alpha-2-HS-Glycoprotein
keywords: Alpha-2-HS-glycoprotein; chronic lymphocytic leukemia; fetuin-A; insulin; malignancy