title: Metastasis of circulating tumor cells: favorable soil or suitable biomechanics, or both?
abstract: Metastasis is the end product of a multistep process where cancer cells disseminate and home themselves in distant organs. Tumor cell extravasation is a rare, inefficient and transient event in nature and makes its studies very difficult. Noteworthy, little is known about how cancer cells arrest, adhere and pass through the endothelium of capillaries. Moreover, the key events driving metastatic growth in specific organs are not well understood. Thus, although metastasis is the leading cause of cancer-related death, how cancer cells acquire their abilities to colonize distant organs and why they do so in specific locations remain central questions in the understanding of this deadly disease. In this review, we would like to confront 2 concepts explaining the efficiency and location of metastatic secondary tumors. While the "seed and soil" hypothesis states that metastasis occurs at sites where the local microenvironment is favorable, the "mechanical" concept argues that metastatic seeding occurs at sites of optimal flow patterns. In addition, recent evidence suggests that the primary event driving tumor cell arrest before extravasation is mostly controlled by blood circulation patterns as well as mechanical cues during the process of extravasation. In conclusion, the organ tropism displayed by cancer cells during metastatic colonization is a multi-step process, which is regulated by the delivery and survival of circulating tumor cells (CTCs) through blood circulation, the ability of these CTCs to adhere and cross the physical barrier imposed by the endothelium and finally by the suitability of the soil to favor growth of secondary tumors.
authors: a Inserm U1109; MN3T ; Strasbourg , France.|b Université de Strasbourg ; Strasbourg , France.|c LabEx Medalis; Université de Strasbourg ; Strasbourg , France.|d Fédération de Médecine Translationnelle de Strasbourg (FMTS) ; Strasbourg , France.
authors: Ana Sofia
authors: AS
authors: Azevedo
authors: a Inserm U1109; MN3T ; Strasbourg , France.|b Université de Strasbourg ; Strasbourg , France.|c LabEx Medalis; Université de Strasbourg ; Strasbourg , France.|d Fédération de Médecine Translationnelle de Strasbourg (FMTS) ; Strasbourg , France.
authors: Gautier
authors: G
authors: Follain
authors: a Inserm U1109; MN3T ; Strasbourg , France.|b Université de Strasbourg ; Strasbourg , France.|c LabEx Medalis; Université de Strasbourg ; Strasbourg , France.|d Fédération de Médecine Translationnelle de Strasbourg (FMTS) ; Strasbourg , France.
authors: Shankar
authors: S
authors: Patthabhiraman
authors: b Université de Strasbourg ; Strasbourg , France.|e IPCMS UMR7504 ; Strasbourg , France.|f LabEx NIE; Université de Strasbourg ; Strasbourg , France.
authors: Sébastien
authors: S
authors: Harlepp
authors: a Inserm U1109; MN3T ; Strasbourg , France.|b Université de Strasbourg ; Strasbourg , France.|c LabEx Medalis; Université de Strasbourg ; Strasbourg , France.|d Fédération de Médecine Translationnelle de Strasbourg (FMTS) ; Strasbourg , France.
authors: Jacky G
authors: JG
authors: Goetz
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001775:Blood Circulation; D060833:Cellular Microenvironment / Q000502:physiology*; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D018523:Tropism
keywords: extravasation, metastasis, microenvironment, biomechanics, blood flow, circulating tumor cell