title: Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.
abstract: Translation in eukaryotes is followed to detect toxins and virulence factors and coupled to the induction of defence pathways. Caenorhabditis elegans germline-specific mutations in translation components are detected by this system to induce detoxification and immune responses in distinct somatic cells. An RNA interference screen revealed gene inactivations that act at multiple steps in lipid biosynthetic and kinase pathways upstream of MAP kinase to mediate the systemic communication of translation defects to induce detoxification genes. Mammalian bile acids can rescue the defect in detoxification gene induction caused by C. elegans lipid biosynthetic gene inactivations. Extracts prepared from C. elegans with translation deficits but not from the wild type can also rescue detoxification gene induction in lipid-biosynthesis-defective strains. These eukaryotic antibacterial countermeasures are not ignored by bacteria: particular bacterial species suppress normal C. elegans detoxification responses to mutations in translation factors.
authors: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors: J Amaranath
authors: JA
authors: Govindan
authors: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.
authors: Elamparithi
authors: E
authors: Jayamani
authors: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors: Xinrui
authors: X
authors: Zhang
authors: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors: Peter
authors: P
authors: Breen
authors: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors: Jonah
authors: J
authors: Larkins-Ford
authors: Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.
authors: Eleftherios
authors: E
authors: Mylonakis
authors: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors: Gary
authors: G
authors: Ruvkun
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001419:Bacteria / Q000276:immunology; D053898:Biosynthetic Pathways / Q000235:genetics; D017173:Caenorhabditis elegans / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D018095:Germ-Line Mutation; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology*; D008055:Lipids / Q000096:biosynthesis*; D020935:MAP Kinase Signaling System / Q000235:genetics / Q000276:immunology; D008856:Microscopy, Fluorescence; D011135:Polysaccharides, Bacterial / Q000276:immunology; D014176:Protein Biosynthesis / Q000235:genetics; D034622:RNA Interference / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D015262:Xenobiotics / Q000276:immunology / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; C000591383:Kocuran; D008055:Lipids; D011135:Polysaccharides, Bacterial; D015262:Xenobiotics; D049452:Green Fluorescent Proteins