title: Is non-thyroidal illness syndrome a predictor for prolonged weaning in intubated chronic obstructive pulmonary disease patients?
abstract: BACKGROUND
  Non-thyroidal illness syndrome (NTIS) is considered to be associated with adverse outcomes in intensive care unit (ICU) patients. In this study, we evaluated the association between NTIS and prolonged weaning in chronic obstructive pulmonary disease (COPD) patients admitted to the ICU.
  
  
  METHODS
  In total, 125 patients with COPD admitted to our ICU who underwent invasive mechanical ventilation (MV) were enrolled. We collected each patient's baseline characteristics including Acute Physiology and Chronic Health Evaluation (APACHE) II score, body mass index (BMI), and thyroid hormones 24 h after ICU admission. The presence of pulmonary infection was also recorded. The primary outcome was prolonged weaning, defined as patients who failed at least three weaning attempts or required > 7 days of weaning after the first spontaneous breathing trial.
  
  
  RESULTS
  Of the 127 patients studied, 64 had normal thyroid function tests and 61 had NTIS. Patients with NTIS had significantly higher APACHE II scores, prolonged weaning, and pulmonary infection. Patients with NTIS had a higher risk for prolonged weaning (odds ratio, OR = 3.21; 95% CI = 1.31-7.83).The presence of pulmonary infection was also an independent risk factors for prolonged weaning.
  
  
  CONCLUSIONS
  NTIS may be an independent predictor for prolonged weaning in intubated COPD patients.
authors: Department of Chest Diseases, Abant Izzet Baysal University School of Medicine Bolu, Turkey.
authors: Zehra
authors: Z
authors: Yasar
authors: Pulmonary Division, Dr. Suat Seren Chest Diseases and Surgery Teaching and Research Hospital Izmir, Turkey.
authors: Cenk
authors: C
authors: Kirakli
authors: Pulmonary Division, Dr. Suat Seren Chest Diseases and Surgery Teaching and Research Hospital Izmir, Turkey.
authors: Pınar
authors: P
authors: Cimen
authors: Pulmonary Division, Dr. Suat Seren Chest Diseases and Surgery Teaching and Research Hospital Izmir, Turkey.
authors: Zeynep Zeren
authors: ZZ
authors: Ucar
authors: Department of Chest Diseases, Abant Izzet Baysal University School of Medicine Bolu, Turkey.
authors: Fahrettin
authors: F
authors: Talay
authors: Pulmonary Division, Dr. Suat Seren Chest Diseases and Surgery Teaching and Research Hospital Izmir, Turkey.
authors: Gultekin
authors: G
authors: Tibet
keywords: COPD; ICU; NTIS; prolonged weaning