title: The Ratio KL-6 to SLX in Serum for Prediction of the Occurrence of Drug-Induced Interstitial Lung Disease in Lung Cancer Patients with Idiopathic Interstitial Pneumonias Receiving Chemotherapy.
abstract: We retrospectively evaluated whether the ratio KL-6 to SLX in serum (K/S ratio) before chemotherapy was a predictor for the occurrence of drug-induced interstitial lung disease (D-ILD) in lung cancer patients with idiopathic interstitial pneumonias (IIPs). D-ILD occurred in 8 of 20 IIPs-positive cases and in 14 of 100 IIPs-negative cases (40 vs. 14%, p = .015). In IIPs-positive cases, the high K/S ratio (>20) before first-line chemotherapy had a tendency to increase the risk of D-ILD (p = .085). Serum K/S ratio may be a useful predictor for the occurrence of D-ILD in lung cancer patients with IIPs.
authors: a Department of Respiratory Medicine , Kumamoto Regional Medical Center , Kumamoto , Japan.
authors: Kosuke
authors: K
authors: Kashiwabara
authors: a Department of Respiratory Medicine , Kumamoto Regional Medical Center , Kumamoto , Japan.
authors: Hiroshi
authors: H
authors: Semba
authors: a Department of Respiratory Medicine , Kumamoto Regional Medical Center , Kumamoto , Japan.
authors: Shinji
authors: S
authors: Fujii
authors: a Department of Respiratory Medicine , Kumamoto Regional Medical Center , Kumamoto , Japan.
authors: Shinsuke
authors: S
authors: Tsumura
authors: a Department of Respiratory Medicine , Kumamoto Regional Medical Center , Kumamoto , Japan.
authors: Ryota
authors: R
authors: Aoki
mesh_terms: D000368:Aged; D004706:Endodeoxyribonucleases; D004720:Endonucleases / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000188:drug therapy*; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D018396:Mucin-1 / Q000097:blood / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: C060192:MUC1 protein, human; D018396:Mucin-1; D004706:Endodeoxyribonucleases; D004720:Endonucleases; C542320:SLX1 protein, human
keywords: Drug-induced interstitial lung disease; Idiopathic interstitial pneumonias; KL-6; Lung cancer; SLX