title: Multiscale modeling of tumor growth induced by circadian rhythm disruption in epithelial tissue.
abstract: We propose a multiscale chemo-mechanical model of cancer tumor development in epithelial tissue. The model is based on the transformation of normal cells into a cancerous state triggered by a local failure of spatial synchronization of the circadian rhythm. The model includes mechanical interactions and a chemical signal exchange between neighboring cells, as well as a division of cells and intercalation that allows for modification of the respective parameters following transformation into the cancerous state. The numerical simulations reproduce different dephasing patterns--spiral waves and quasistationary clustering, with the latter being conducive to cancer formation. Modification of mechanical properties reproduces a distinct behavior of invasive and localized carcinoma.
authors: Theoretical Physics Department, Perm State Humanitarian Pedagogical University, 614990, Perm, Russia.
authors: D A
authors: DA
authors: Bratsun
authors: Department of Hospital Pediatrics, Perm State Medical Academy, 614990, Perm, Russia.
authors: D V
authors: DV
authors: Merkuriev
authors: Department of Chemical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel. andreiz@tx.technion.ac.il.
authors: A P
authors: AP
authors: Zakharov
authors: Department of Chemical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel. pismen@technion.ac.il.
authors: L M
authors: LM
authors: Pismen
mesh_terms: D001696:Biomechanical Phenomena; D063646:Carcinogenesis; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D002940:Circadian Rhythm; D004848:Epithelium / Q000473:pathology*; D025461:Feedback, Physiological; D015972:Gene Expression Regulation, Neoplastic; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*; D015398:Signal Transduction
keywords: Cancer modeling; Circadian rhythms; Signaling; Systems biology; Time-delay