title: In serum, higher parathyroid hormone but not lower vitamin D is associated with oral squamous cell carcinoma.
abstract: BACKGROUND
  Vitamin D and calcium are known to regulate differentiation and proliferation of keratinocytes; they might potentially have a role in suppressing carcinogenesis in squamous epithelium. Serum parathyroid hormone (pth) is a sensitive indicator of calcium and vitamin D deficiency, and 25-hydroxyvitamin D [25(OH)D] is an established marker of vitamin D status.
  
  
  METHODS
  To determine whether levels of 25(OH)D, calcium, or pth in serum are associated with oral squamous cell carcinoma (oscc), we examined those parameters in serum collected from 70 patients with oscc and from an equal number of matched control subjects.
  
  
  RESULTS
  The results showed that intact pth was significantly higher in serum from oscc patients than in serum from control subjects. However, we observed no significant differences in 25(OH)D or calcium in serum from oscc patients and from control subjects.
  
  
  CONCLUSIONS
  We conclude that higher serum pth, but not lower serum vitamin D or calcium, is associated with oscc.
authors: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
authors: H
authors: H
authors: Zhang
authors: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
authors: H
authors: H
authors: Lu
authors: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
authors: C
authors: C
authors: Shrestha
authors: Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, PRC;
authors: Y
authors: Y
authors: Feng
authors: Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, PRC;
authors: Y
authors: Y
authors: Li
authors: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
authors: J
authors: J
authors: Peng
authors: Stomatological Hospital of Xiangtan, Xiangtan, PRC.
authors: Y
authors: Y
authors: Li
authors: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
authors: Z
authors: Z
authors: Xie
keywords: 25-hydroxyvitamin D; Oral squamous cell carcinoma; calcium; parathyroid hormone