title: Sesamolin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt's lymphoma cells.
abstract: Sesamolin and sesamin are representative lignans found in sesame seed. The present study was designed to demonstrate the anti-cancer activity of sesamolin achieved by increasing the expression level of NKG2D ligands on Raji cells, which are derived from Burkitt's lymphoma. The anti-cancer activity of sesamolin was also compared with that of sesamin. The cytolysis activity of NK cells against Raji was elevated by the pretreatment of sesamolin on Raji, but not by sesamin. We found that higher NKG2D ligand expression increased the sensitivity of sesamolin-treated Raji to NK cell lysis, resulting from a more active ERK signaling pathway. Our results provide evidence that targeting the ERK signaling pathway may enhance the antitumor activity of lignans and that there is a potential immunotherapeutic value for cancer treatment.
authors: Department of Biology Education, College of Education, Chungbuk National University, Chungbuk 361-763, Republic of Korea; College of Pharmacy, Chungbuk National University, Chungbuk 361-763, Republic of Korea.
authors: Jeong Hwa
authors: JH
authors: Kim
authors: Department of Biology Education, College of Education, Chungbuk National University, Chungbuk 361-763, Republic of Korea. Electronic address: chemokine@cbnu.ac.kr.
authors: Jae Kwon
authors: JK
authors: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D002051:Burkitt Lymphoma / Q000188:drug therapy* / Q000276:immunology; D045744:Cell Line, Tumor; D003602:Cytotoxicity, Immunologic; D004149:Dioxoles / Q000494:pharmacology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D017705:Lignans / Q000494:pharmacology; D020935:MAP Kinase Signaling System / Q000187:drug effects; D058990:Molecular Targeted Therapy; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000235:genetics / Q000378:metabolism*; D012639:Seeds; D031685:Sesamum; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004149:Dioxoles; D017705:Lignans; D055655:NK Cell Lectin-Like Receptor Subfamily K; C054124:sesamolin; C054125:sesamin
keywords: NKG2D ligands; Natural killer cell; Raji; Sesamin; Sesamolin