title: [Exome sequencing in the research of genetic eye diseases].
abstract: There are a variety of genetic eye diseases. In the past years, many methods such as linkage analysis and association analysis have been used to study these diseases and lots of achievements have been made. With the development of the second-generation sequencing technology, DNA sequencing has become much more efficient and cheaper. Exome trapping, combining with the second-generation sequencing technology, has become efficient and accurate means to sequence DNA and screen disease-causing genes. This review outlines the research progresses in eye inherited diseases, the methodological characteristics of second-generation sequencing and exome trapping and their applications in genetic eye diseases.
authors: Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Key Laboratory of Health Ministry for Myopia, Shanghai 200031, China.
authors: Xueying
authors: X
authors: Zhou
authors: Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Key Laboratory of Health Ministry for Myopia, Shanghai 200031, China; Email: yuzhiqiang@cooc.cn.
authors: Zhiqiang
authors: Z
authors: Yu
mesh_terms: D035843:Biomedical Research; D059472:Exome; D005128:Eye Diseases / Q000235:genetics; D015785:Eye Diseases, Hereditary / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D017422:Sequence Analysis, DNA