title: Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer.
abstract: Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.
authors: The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Institute of Forensic Medicine, Department of Molecular and Forensic Genetics, Bydgoszcz, Poland.
authors: Katarzyna
authors: K
authors: Linkowska
authors: The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Chair of Vascular Surgery and Angiology, Bydgoszcz, Poland.
authors: Arkadiusz
authors: A
authors: Jawień
authors: The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Chair & Department of Clinical Pathomorphology, Bydgoszcz, Poland.
authors: Andrzej
authors: A
authors: Marszałek
authors: The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Institute of Forensic Medicine, Department of Molecular and Forensic Genetics, Bydgoszcz, Poland.
authors: Katarzyna
authors: K
authors: Skonieczna
authors: The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Institute of Forensic Medicine, Department of Molecular and Forensic Genetics, Bydgoszcz, Poland.
authors: Tomasz
authors: T
authors: Grzybowski
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009154:Mutation; D011044:Poland; D011110:Polymorphism, Genetic; D018911:Trinucleotide Repeats
chemical_list: D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase; C413027:POLG protein, human