title: [Amount Change of Peripheral Blood NK Cells in Patients with Hematologic Malignancies and Its Clinical Significance].
abstract: OBJECTIVE
  To study the amount change of peripheral blood NK cells in patients with hematologic malignancies and its significance.
  
  
  METHODS
  A total of 200 patients with hematologic malignancies in our hospital from June 2013 to March 2015 were chosen as study objects, out of them 105 patients were in aute stage and 95 patients were in remisson stage. At same time 100 people from healthy medical examination in our hospital were chosen as control group. The mumber change and subgroups of their peripheral blood NK cells were analyzed and compared.
  
  
  RESULTS
  In control group the absolute number of NK cells was (412.91 ± 167.35)/µl, the relative number of NK cells was (13.31 ± 2.56) %; in group at acute stage of leukemia the absolute number of NK cells was (97.84 ± 23.18)/µl, the relative number of NK cells was (6.79 ± 0.78) %; in group at acute stage of lymphoma, the absolute number of NK cells was (101.79 ± 25.63)/µl, and the relative number of NK cells was (7.12 ± 1.03) %; in group at remission stage of leukemia, the absolute number was (297.17 ± 87.56)/µl, and the relative number was (10.15 ± 1.64) %; In group at remission of lymphoma, the absolute number of NK cells was (288.52 ± 118.52)/µl, and the relative number of NK cells was (10.82 ± 1.97) %. The number of NK cells between different groups showed statistical difference (P < 0.05). In remission group, the number of NK cells before and after treatment had statistical difference (P < 0.05). In control group, the number of CD56(bright) subgroup was (25.28 ± 4.72) %, the number of CD56(bright) subgroup at the acute stage of leukemia was (65.46 ± 11.21) %, and the number of CD56(bright) subgroup at the acute stage of lymphoma was (70.71 ± 12.14) %, the number of CD56(bright) subgroup at remission stage of leukemia was (23.35 ± 4.67) %, the number of CD56(bright) subgroup at remission stage of lymphoma was (24.89 ± 4.58) %. The number of CD56(bright) subgroup between different groups showed statistical significance (P < 0.05).
  
  
  CONCLUSIONS
  The number and function of peripheral blood NK cells in patients with hematologic malignancies have been confirmed to be obvious decrement, but after treatment the number of NK cells in those patients showed increment.
authors: Department of Laboratorial Examination, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, FuJian Province, China. E-mail: fujianzhengshuxia@126.com.
authors: Shu-Xia
authors: SX
authors: Zheng
authors: Department of Laboratorial Examination, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, FuJian Province, China.
authors: Ruo-Teng
authors: RT
authors: Xie
authors: Department of Laboratorial Examination, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, FuJian Province, China.
authors: Rui-Ting
authors: RT
authors: Guan
authors: Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, FuJian Province, China.
authors: Jian-Xin
authors: JX
authors: Guo
mesh_terms: D019002:CD56 Antigen; D019337:Hematologic Neoplasms; D006801:Humans; D007694:Killer Cells, Natural
chemical_list: D019002:CD56 Antigen; C522918:NCAM1 protein, human