title: Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection.
abstract: Canine parvovirus (CPV) infection induces reorganization of nuclear structures. Our studies indicated that late-stage infection induces accumulation of nuclear pore complexes (NPCs) and lamin B1 concomitantly with a decrease of lamin A/C levels on the apical side of the nucleus. Newly formed CPV capsids are located in close proximity to NPCs on the apical side. These results suggest that parvoviruses cause apical enrichment of NPCs and reorganization of nuclear lamina, presumably to facilitate the late-stage infection.
authors: Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.
authors: Elina
authors: E
authors: Mäntylä
authors: Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
authors: Einari A
authors: EA
authors: Niskanen
authors: NeuroGroup, BioMediTech, University of Tampere, Tampere, Finland.
authors: Teemu O
authors: TO
authors: Ihalainen
authors: Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland maija.vihinen-ranta@jyu.fi.
authors: Maija
authors: http://orcid.org/0000-0003-0959-1153
authors: M
authors: Vihinen-Ranta
mesh_terms: D000818:Animals; D002213:Capsid / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D034904:Lamin Type A / Q000378:metabolism; D034921:Lamin Type B / Q000378:metabolism*; D034881:Nuclear Lamina / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*; D010322:Parvoviridae Infections / Q000821:virology*; D017993:Parvovirus, Canine / Q000378:metabolism*
chemical_list: D034904:Lamin Type A; D034921:Lamin Type B; D028861:Nuclear Pore Complex Proteins