title: Adenoid ameloblastoma: clinicopathologic description of five cases and systematic review of the current knowledge.
abstract: OBJECTIVE
  To describe the clinicopathologic and immunohistochemical features of five cases of adenoid ameloblastoma.
  
  
  METHODS
  Clinicopathologic data were gathered from medical records and compared with those compiled from a systematic review. Slides were also immunohistochemically stained for Ki-67, p16, p53, and cytokeratins (7, 8, 14, 18, and 19).
  
  
  RESULTS
  There were 3 males (60%) and 2 (40%) females. The mean age was 44 ± 10 years. Of the five adenoid ameloblastomas, 4 (80%) occurred in the posterior maxilla. Patients typically complained of asymptomatic swelling. All patients received surgical resection as primary therapy; 1 (20%) patient also received adjuvant radiotherapy. Recurrence was diagnosed in all patients. Immunohistochemically, the tumors stained focally positive for CK7, 8, 14, and 18 and diffusely positive for CK-19, p16, and p53. The mean Ki-67-positive cells were 72.4 ± 24.9 positive cells per high-power field (range 53-111).
  
  
  CONCLUSIONS
  To our knowledge, this is the largest series of adenoid ameloblastoma reported in the literature. Our data suggest that this entity demonstrates aggressive behavior characterized by a high likelihood of recurrence.
authors: Associate Professor, Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia (MG), Brazil. Electronic address: Loyolaam@yahoo.com.br.
authors: Adriano Mota
authors: AM
authors: Loyola
authors: Adjunct Professor, Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia (MG), Brazil.
authors: Sergio Vitorino
authors: SV
authors: Cardoso
authors: Adjunct Professor, Department of Morphology, Biomedical Science Institute, Federal University of Uberlândia, Uberlândia (MG), Brazil.
authors: Paulo Rogério
authors: PR
authors: de Faria
authors: PhD Student, Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia (MG), Brazil.
authors: João Paulo Silva
authors: JP
authors: Servato
authors: Pathologist, Division of Pathology, Brazilian National Institute of Cancer, Rio de Janeiro (RJ), Brazil.
authors: Ana Lúcia Amaral
authors: AL
authors: Eisenberg
authors: Head and Neck Surgeon, Division of Head and Neck Surgery, Brazilian National Institute of Cancer, Rio de Janeiro (RJ), Brazil.
authors: Fernando Luiz
authors: FL
authors: Dias
authors: Honorary Consultant in Oral/Head and Neck Pathology, Guy's & St Thomas' NHS Foundation Trust; Lecturer in Oral and Maxillofacial Pathology, King's College London Dental Institute, UK.
authors: Selvam
authors: S
authors: Thavaraj
authors: Adjunct Professor, Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil.
authors: Carolina Cavalieri
authors: CC
authors: Gomes
authors: Titular Professor, Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil.
authors: Ricardo Santiago
authors: RS
authors: Gomez
mesh_terms: D000234:Adenoids / Q000473:pathology*; D000328:Adult; D000564:Ameloblastoma / Q000473:pathology* / Q000628:therapy; D014408:Biomarkers, Tumor / Q000032:analysis; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D053539:Keratin-19 / Q000032:analysis; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D009363:Neoplasm Proteins / Q000032:analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000032:analysis; D019061:src-Family Kinases / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D053539:Keratin-19; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; C053102:proto-oncogene proteins c-fgr; D019061:src-Family Kinases