title: Hypopituitarism and Legg-Calve-Perthes disease related to difficult delivery.
abstract: Legg-Calve-Perthes (LCP) disease is characterized by idiopathic avascular osteonecrosis of the epiphysis of the femur head. The main factor that plays a role in the etiology of the disease is decreased blood flow to the epiphysis. Many predisposing factors have been suggested in the etiology of LCP disease, and most have varying degrees of effects. Here we present the case of a boy aged 4 years and 10 months with complaints of short stature and a diagnosis of multiple hypophyseal hormone deficiency, in whom LCP disease and difficult birth-related pituitary stalk interruption syndrome were identified by anamnesis. The present case revealed that LCP disease and hypophyseal hormone deficiency could be secondary to difficult birth and that LCP disease could be secondary to insulin-like growth factor 1 deficiency. Additionally, to the best of our knowledge there is no published case on the relation between LCP disease and insulin-like growth factor 1 deficiency. Therefore, we believe that this case is worthy of presentation.
authors: Department of Pediatric Endocrinology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors: Veysel Nijat
authors: VN
authors: Baş
authors: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors: Salih
authors: S
authors: Uytun
authors: Department of Radiology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors: Ümit Erkan
authors: ÜE
authors: Vurdem
authors: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors: Yasemin Altuner
authors: YA
authors: Torun
keywords: Hypopituitarism; Insulin-like growth factor-1; Legg-Calve-Perthes disease