title: Balance and coordination training, but not endurance training, enhances synaptophysin and neurotrophin-3 immunoreactivity in the lumbar spinal cord after sciatic nerve crush.
abstract: BACKGROUND
  Numerous rehabilitation treatments have been shown to be useful for peripheral and central restoration after (PNI).
  
  
  METHODS
  After sciatic nerve crush, we investigated 4 weeks of endurance training (ET) and balance and coordination training (BCT) with sciatic function index, hind-paw stride length, and spinal cord dorsal horn synaptophysin and neurotrophin-3 immunoreactivity.
  
  
  RESULTS
  Our results demonstrated no significant differences between the non-trained (NT), ET, and BCT groups in sciatic functional index, and in stride-length analysis, but the ET showed higher values compared with the NT group. Synaptophysin immunoreactivity was higher in the BCT group compared with the NT group, and neurotrophin-3 immunoreactivity in the BCT group was greater compared with the other groups.
  
  
  CONCLUSIONS
  BCT can positively affect spinal cord plasticity after a (PNI), and these modifications are important in the rehabilitation process.
authors: Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.|Laboratório de Histofisiologia Comparada, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Sarmento Leite 500, CEP 90050-170, Porto Alegre, Rio Grande do Sul, Brazil.
authors: Leandro Viçosa
authors: LV
authors: Bonetti
authors: Laboratório de Pesquisa Experimental, Departamento de Fisioterapia, Universidade do Estado de Santa Catarina, Santa Catarina, Brazil.
authors: Jocemar
authors: J
authors: Ilha
authors: Laboratório de Histofisiologia Comparada, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Sarmento Leite 500, CEP 90050-170, Porto Alegre, Rio Grande do Sul, Brazil.
authors: Ana Paula Krauthein
authors: AP
authors: Schneider
authors: Laboratório de Histofisiologia Comparada, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Sarmento Leite 500, CEP 90050-170, Porto Alegre, Rio Grande do Sul, Brazil.
authors: Silvia
authors: S
authors: Barbosa
authors: Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.|Laboratório de Histofisiologia Comparada, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Sarmento Leite 500, CEP 90050-170, Porto Alegre, Rio Grande do Sul, Brazil.
authors: Maria Cristina
authors: MC
authors: Faccioni-Heuser
mesh_terms: D000818:Animals; D008159:Lumbar Vertebrae; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009409:Nerve Crush / Q000379:methods; D020933:Neurotrophin 3 / Q000032:analysis / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000379:methods / Q000502:physiology*; D010807:Physical Endurance / Q000502:physiology; D004856:Postural Balance / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D020426:Sciatic Neuropathy / Q000378:metabolism*; D013116:Spinal Cord / Q000737:chemistry / Q000378:metabolism*; D016708:Synaptophysin / Q000032:analysis / Q000378:metabolism*
chemical_list: D020933:Neurotrophin 3; D016708:Synaptophysin; C569016:Syp protein, rat
keywords: balance; coordination; endurance; neurotrophin; synaptophysin