title: A Shared Molecular and Genetic Basis for Food and Drug Addiction: Overcoming Hypodopaminergic Trait/State by Incorporating Dopamine Agonistic Therapy in Psychiatry.
abstract: This article focuses on the shared molecular and neurogenetics of food and drug addiction tied to the understanding of reward deficiency syndrome. Reward deficiency syndrome describes a hypodopaminergic trait/state that provides a rationale for commonality in approaches for treating long-term reduced dopamine function across the reward brain regions. The identification of the role of DNA polymorphic associations with reward circuitry has resulted in new understanding of all addictive behaviors.
authors: Departments of Psychiatry & Behavioral Sciences, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA 90033, USA; Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA; Rivermend Health Scientific Advisory Board, 2300 Windy Ridge Parkway South East, Suite 210S, Atlanta, GA 30339, USA; Drug Enforcement Administration (DEA) Educational Foundation, Washington, DC, USA. Electronic address: drmarkgold@gmail.com.
authors: Mark S
authors: MS
authors: Gold
authors: Laboratory of Advanced Radiochemistry and Molecular and Functioning Imaging, Department of Psychiatry, College of Medicine, University of Minnesota, Minneapolis, MN, USA.
authors: Rajendra D
authors: RD
authors: Badgaiyan
authors: Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, USA; Department of Psychiatry, Center for Clinical & Translational Science, Community Mental Health Institute, University of Vermont College of Medicine, University of Vermont, Burlington, VT, USA; Division of Applied Clinical Research, Dominion Diagnostics, LLC, 211 Circuit Drive, North Kingstown, RI 02852, USA; Rivermend Health Scientific Advisory Board, Atlanta, GA, USA.
authors: Kenneth
authors: K
authors: Blum
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000188:drug therapy* / Q000235:genetics*; D001921:Brain / Q000187:drug effects; D002032:Bulimia / Q000188:drug therapy / Q000235:genetics; D018491:Dopamine Agonists / Q000494:pharmacology* / Q000627:therapeutic use*; D004435:Eating / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008959:Models, Neurological; D012201:Reward; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D018491:Dopamine Agonists
keywords: Dopamine agonistic therapy; Drug addiction; Food addiction; Genetic basis; Hypodopaminergic state; Molecular basis; Psychiatry