title: Molecular Pathogenesis of Corneal Dystrophies: Schnyder Dystrophy and Granular Corneal Dystrophy type 2.
abstract: The International Committee for Classification of Corneal Dystrophies (IC3D) provides updated data to ophthalmologists by incorporating traditional definitions of corneal dystrophies with new genetic, clinical, and pathologic information. Recent advances in the genetics of corneal dystrophies facilitate more precise classifications and elucidate each classification's molecular mechanisms. Unfortunately, the molecular mechanisms and underlying pathogenic mechanisms have remained obscure, with the exception of Schnyder corneal dystrophy (CD), granular CD type 2 (GCD2), and Fuch's endothelial CD. Here, we review the pathogenesis of Schnyder CD and GCD2.
authors: Department of Ophthalmology, Vision Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; BK21 Plus Project for Medical Science and Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: eungkkim@yuhs.ac.
authors: Eung Kweon
authors: EK
authors: Kim
authors: Department of Ophthalmology, Vision Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Hun
authors: H
authors: Lee
authors: Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Seung-Il
authors: SI
authors: Choi
mesh_terms: D003317:Corneal Dystrophies, Hereditary / Q000235:genetics*; D006801:Humans; D050356:Lipid Metabolism; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D018384:Oxidative Stress
keywords: Granular corneal dystrophy type 2; Pathogenesis; Schnyder corneal dystrophy