title: IL-20 in rheumatoid arthritis.
abstract: Rheumatoid arthritis, a systemic autoimmune disease, causes chronic joint inflammation and bone destruction. Interleukin (IL)-20's association with this disease, and its expression and regulation has been extensively studied since 2006. Anti-IL-20 antibody has paved the way to clinical trials aimed at blocking the pathogenic actions of IL-20 in rheumatoid arthritis. This review focuses on current knowledge of IL-20's involvement in the pathogenesis of rheumatoid arthritis.
authors: Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors: Yu-Hsiang
authors: YH
authors: Hsu
authors: Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: mschang@mail.ncku.edu.tw.
authors: Ming-Shi
authors: MS
authors: Chang
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D019902:Chondrocytes / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007378:Interleukins / Q000276:immunology*; D010006:Osteoblasts / Q000276:immunology; D010010:Osteoclasts / Q000276:immunology
chemical_list: D000906:Antibodies; D007378:Interleukins; C422042:interleukin 20