title: Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation.
abstract: BACKGROUND
  Human leukocyte antigen (HLA)-B*5701 is strongly associated with developing a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*5701 prevalence in HIV-1-infected subjects in China. We investigated HLA-B*5701 prevalence in HIV-1-infected population including Han and non-Han ethnic groups.
  
  
  METHODS
  A prospective multi-centre study was designed to determine status of HLA-B*5701 in HIV-1-infected adults at six sites across China. HLA-B*5701 was tested by the method of PCR-SSP.
  
  
  RESULTS
  From six centers, 3,000 HIV-infected patients [2,452 (81.7%) Han, 548 (18.3%) Non-Han] were recruited with a mean age of 36.7 years old. The overall HLA-B*5701 prevalence was 0.86% [95% confidence interval (CI) 0.55-1.26%]. The prevalence of HLA-B*5701 among Han subjects was similar to that among non-Han subjects, which was 0.88% (95% CI 0.54-1.34%) and 0.76% (95% CI 0.19-1.93%), respectively (p value = 0.787). There were no differences in prevalence of HLA-B*5701 between subjects born in Henan, Yunnan, Shanxi, Guangdong, Hebei, Beijing and other provinces (p = 0.999).
  
  
  CONCLUSIONS
  HLA-B*5701 prevalence is very low in HIV-infected Chinese subjects, both in the Han and Non-Han nationalities. And there are no differences among different birthplaces across China.
authors: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's Republic of China.
authors: Hongwei
authors: H
authors: Zhang
authors: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's Republic of China.
authors: Tong
authors: T
authors: Zhang
authors: Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100069 China.
authors: Hongxin
authors: H
authors: Zhao
authors: Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100069 China.
authors: Ning
authors: N
authors: Han
authors: Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100069 China.
authors: Haiwei
authors: H
authors: Zhou
authors: Department of Infectious Diseases, The 6th People Hospital of Zhengzhou, Zhengzhou, 450015 China.
authors: Yun
authors: Y
authors: He
authors: Department of Infectious Diseases, The 6th People Hospital of Zhengzhou, Zhengzhou, 450015 China.
authors: Qingxia
authors: Q
authors: Zhao
authors: Department of Infectious Diseases, The 6th People Hospital of Zhengzhou, Zhengzhou, 450015 China.
authors: Hong
authors: H
authors: Li
authors: Yunnan AIDS Care Center, Kunming, 650301 China.
authors: Huiqin
authors: H
authors: Li
authors: Yunnan AIDS Care Center, Kunming, 650301 China.
authors: Mi
authors: M
authors: Zhang
authors: Yunnan AIDS Care Center, Kunming, 650301 China.
authors: Jianjian
authors: J
authors: Li
authors: Department of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038 China.
authors: Yongtao
authors: Y
authors: Sun
authors: Department of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038 China.
authors: Ke
authors: K
authors: Zhao
authors: Department of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038 China.
authors: Qing
authors: Q
authors: Liu
authors: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's Republic of China.
authors: Zhiying
authors: Z
authors: Liu
authors: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's Republic of China.
authors: Zhen
authors: Z
authors: Li
authors: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's Republic of China.
authors: Wei
authors: W
authors: Xia
authors: Department of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou, 510060 China.
authors: Yun
authors: Y
authors: Lan
authors: Department of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou, 510060 China.
authors: Haolan
authors: H
authors: Hu
authors: Department of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou, 510060 China.
authors: Weiping
authors: W
authors: Cai
authors: Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's Republic of China.
authors: Hao
authors: H
authors: Wu
keywords: HIV; HLA-B*5701; Prevalence