title: [Clinical Value of Arsenous Acid for Treating Patients with Acute Promyelocytic Leukemia].
abstract: OBJECTIVE
  To explore the clinical value of arsenious acid (H3AsO3) for treating patients with acute promyelocytic leukemia (APL).
  
  
  METHODS
  A total of 86 patients with APL were randomly divided into experimental group (43 cases) and control group (43 cases). The control group was treated by all trans retinoic acid combined with chemotherapy, the experimental group were treated by arsenous acid on the basis of the control group.
  
  
  RESULTS
  The overall response rate (ORR) in experimental group (100.00%) was significantly higher than that in control group (88.37%) (P < 0.05). The time of returm to complete remission in experimental group (30.86 ± 4.34) was better than that in control group (42.42 ± 7.10) d (P < 0.05). The time of return to normal levels of peripheral WBC count (20.86 ± 9.28) × 10⁹/L, hemoglobin count (68.62 ± 14.97) g/L and thrombocyte count in experimental group obviously less than that in control group (P < 0.05). The rates of high white blood syndrome (HWBS), disseminated intravascular coagulation (DIC) in experimental group were lower than that in control group (P < 0.05). The survival rates of 2 and 3 years in experimental group were higher than that in control group (P < 0.05). The recurrence rate after treatment in experimental group was lower than that in control group (P < 0.05). The application of arsenious acid was main factor for patients survival (P < 0.05).
  
  
  CONCLUSIONS
  Arsenious acid can improve the clinical efficacy for the patients with acute promyelocytic leukemia, and reduce the complication, therefore it is worthy of application in clinic.
authors: Department of Hematology, Nanyang Central Hospital of Henan Province, Nanyang 473009, Henan Province, China.
authors: Li-Juan
authors: LJ
authors: Duan
authors: Department of Hematology, Nanyang Central Hospital of Henan Province, Nanyang 473009, Henan Province, China.
authors: Chao
authors: C
authors: Li
authors: Department of Hematology, Nanyang Central Hospital of Henan Province, Nanyang 473009, Henan Province, China . E-mail: 1034066216@qq.com.
authors: Ru-Yu
authors: RY
authors: Yang
mesh_terms: D018053:Arsenites; D004211:Disseminated Intravascular Coagulation; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute; D007958:Leukocyte Count; D010976:Platelet Count; D012008:Recurrence; D012074:Remission Induction; D015996:Survival Rate; D014212:Tretinoin
chemical_list: D018053:Arsenites; D014212:Tretinoin; C032793:arsenous acid