title: Quality of Life in the Chronic GVHD Consortium Cohort: Lessons Learned and the Long Road Ahead.
abstract: Patient-reported outcomes are receiving increased attention as the search for successful treatment agents of chronic graft versus host disease continues. There is currently an ongoing multicenter, prospective cohort study lead by the Chronic GVHD Consortium of patients with chronic graft versus host disease. This paper summarizes published findings to date reporting factors impacting quality of life, symptom burden, and physical functioning in this cohort. Middle age, versus younger or older age, is associated with worse quality of life, despite lower symptom burden. The presence of chronic graft versus host disease at study enrollment was associated with lower quality of life, and improvement in severity does not always change quality of life. Other factors negatively impacting quality of life include the presence of overlap syndrome, specific gastrointestinal and joint and fascia manifestations, and poorer functional status and exercise tolerance. Collecting valid and concise quality of life data is essential in developing treatment strategies for chronic graft versus host disease.
authors: Pediatric Hematology/Oncology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, 397 PRB, 2220 Pierce Avenue, Nashville, TN, 37232-6310, USA, Christa.Krupski@vanderbilt.edu.
authors: Christa
authors: C
authors: Krupski
authors: Madan
authors: M
authors: Jagasia
mesh_terms: D000367:Age Factors; D002908:Chronic Disease; D015331:Cohort Studies; D017079:Exercise Tolerance; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D053580:Muscle Strength; D063868:Patient Outcome Assessment; D011788:Quality of Life; D057566:Self Report; D012720:Severity of Illness Index; D014481:United States / Q000453:epidemiology