title: [Research Progress on DKK1 Gene in Leukemia].
abstract: A number of studies have demonstrated that the methylation of Dickkopf-1 (DKK1) gene promoter is related with the occurrence and development of many neoplastic diseases. By means of binding with corresponding receptors, DKK1 blocks the transduction pathway of Wnt/β-catenin/TCF and inhibits the proliferation and invasion of tumor cells, inducing apoptosis. Leukemia is a hyperplastic disease of hematopoietic stem cell malignant clone. Its pathogenesis has been confirmed to be closely related with the aberrant activation of Wnt signaling pathway. This pathway is associated with the self-renewal and proliferation of the hematopoietic stem cells, which can regulate growth, differentiation, migration of the cells, angiogenesis and embryonic development. Its expression is regulated by some suppressor genes like Dickkopf 1 (DKK1). Leukemia often accompanied by methylation modification of the DKK1 gene, so as to leads to silencing itself and activation of the Wnt signaling pathway, which cause the occurrence of leukemia. Some therapeutic methods on leukemia aiming at DKK1 gene have been reported, among which DKK1 gene was demethylated. The intensive study on the expression and function of DKK1 should be important for the early diagnosis, treatment and prognosis. This article reviews the current progress in this field.
authors: Department of Hematology, Guizhou Provincial People's Hospital, Guiyang 550002, Guizhou Province, China.
authors: Feng-Zhi
authors: FZ
authors: Liu
authors: Department of Hematology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, China.
authors: Ji-Shi
authors: JS
authors: Wang
authors: Department of Hematology, Guizhou Provincial People's Hospital, Guiyang 550002, Guizhou Province, China. E-mail: zhuhongqian@126.com.
authors: Hong-Qian
authors: HQ
authors: Zhu
mesh_terms: D017209:Apoptosis; D002454:Cell Differentiation; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007938:Leukemia; D051153:Wnt Proteins; D060449:Wnt Signaling Pathway; D051176:beta Catenin
chemical_list: C495270:CTNNB1 protein, human; C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins; D051176:beta Catenin