title: Physicians' opinions following pharmacogenetic testing for psychotropic medication.
abstract: Pharmacogenetics seeks to improve patient drug response and decrease side effects by personalizing prescriptions using genetic information. Since 2012, by one estimate, the number of patients who have had pharmacogenetic testing has doubled and this number is expected to double again by 2015. Given the increasing evidence for genetic influences on treatment response, we deemed it important to study physicians' opinions of pharmacogenetic testing. Surveys were completed by 168 Canadian physicians who had ordered at least one pharmacogenetic test (in particular for CYP2D6 or CYP2C19) for the prescription of psychiatric medication. Our results indicated that 80% of respondents believe genetic testing would become common standard in psychiatric drug treatment and 76% of respondents reported satisfactory or higher than satisfactory understanding of the pharmacogenetic report provided. Significantly more male physicians believed they had a higher understanding of the pharmacogenetic report compared to female physicians. To our knowledge, this is the only study that has assessed physicians' opinions of pharmacogenetic testing for psychotropic medication after they had received a pharmacogenetic report. Our results demonstrate a positive opinion of physicians on pharmacogenetics and indicate great potential for future clinical application.
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
authors: Lucas M
authors: LM
authors: Walden
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors: Eva J
authors: EJ
authors: Brandl
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada; University of Toronto, Scarborough, Ontario, Canada.
authors: Amtul
authors: A
authors: Changasi
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
authors: Jessica E
authors: JE
authors: Sturgess
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
authors: Alexander
authors: A
authors: Soibel
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
authors: Janna Fe D
authors: JF
authors: Notario
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
authors: Sheraz
authors: S
authors: Cheema
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
authors: Nicole
authors: N
authors: Braganza
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada.
authors: Victoria S
authors: VS
authors: Marshe
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
authors: Natalie
authors: N
authors: Freeman
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
authors: Arun K
authors: AK
authors: Tiwari
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: james.kennedy@camh.ca.
authors: James L
authors: JL
authors: Kennedy
authors: Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: daniel.mueller@camh.ca.
authors: Daniel J
authors: DJ
authors: Müller
mesh_terms: D000328:Adult; D001291:Attitude of Health Personnel; D002170:Canada; D005260:Female; D058005:General Practitioners; D005820:Genetic Testing / Q000379:methods / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011570:Psychiatry; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D011619:Psychotropic Drugs
keywords: Clinical; Personalized medicine; Pharmacogenetics; Psychiatry medication; Survey