title: [Expression of Insulin-like Growth Factor Binding Protein 3 in Acute Myeloid Leukemia and Its Clinical Significance].
abstract: OBJECTIVE
  To explore the expression of insulin-like growth factor binding protein 3 (IGFBP3) in acute myeloid leukemia and its clinical significance.
  
  
  METHODS
  Using GAPDH as internal reference, IGFBP3 gene expression was detected in the bone marrow mononuclear cells of 43 de novo AML patients, 36 patients with complete remission (CR) and 28 cases of controls by using SYBR-Green I real-time quantitative PCR, the differences of gene expression between the three groups were compared.
  
  
  RESULTS
  IGFBP3 gene expression level in the de novo group were lower than that in CR group and control group (P < 0.05), but there was no statistically significant difference of IGFBP3 expression level in CR group and control group (P > 0.05).
  
  
  CONCLUSIONS
  The IGFBP3 as a tumor suppressor gene may play a role in the pathogenesis of acute myeloid leukemia, its expression level is recovered after complete remission, therefore, IGFBP3 can be used as an indicator of evaluating clinical curative effect.
authors: Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors: Lin
authors: L
authors: Liu
authors: Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors: Zi-Long
authors: ZL
authors: Liao
authors: Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors: Xiao-Jing
authors: XJ
authors: Yan
authors: Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors: Jie
authors: J
authors: Liu
authors: Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors: Xiao-Ou
authors: XO
authors: Wang
authors: Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. E-mail: fanhua66cn@163.com.
authors: Hua
authors: H
authors: Fan
mesh_terms: D001854:Bone Marrow Cells; D015870:Gene Expression; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3; D015470:Leukemia, Myeloid, Acute; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3