title: [Expression of N-Cadherin in Patients with Multiple Myeloma and Its Clinical Significance].
abstract: OBJECTIVE
  To investigate the expression of N-Cadherin in the patients with multiple myeloma (MM) and to explore its clinical significance.
  
  
  METHODS
  A total of 64 patients with multiple myeloma were enrolled in this study. The expression of N-Cadherin in bone marrow CD38⁺/CD138⁺ cells from multiple myeloma patients was detected by flow cytometry. The relationship between N-Cadherin expression and clinical prognostic factors was analyzed.
  
  
  RESULTS
  Among 64 cases of MM, the expression of N-Cadherin in 17 patients (26.56%) was high (> 20%), while that in 47 cases (73.44%) was low (< 20%); The differences of N-Cadherin expression in disease staging and classification, known prognostic factors, myeloma cell antigen expression and bone damage between patients with high and low N-Cadherin expression were not statistically different; the difference N-Cadherin expression in genetic abnormalities such as D13S319 deletion, RB1 deletion and IGH gene rearrangement between above-methioned two groups was not significant. The 1q21 amplification rate in the group with high expression of N-Cadherin was enhanced significently; the overall survival (OS) times of patients with abnormally high and low expression levels of N-Cadherin were 26.7 months and 55.5 months respectively, and the difference was statistically significant (P < 0.05).
  
  
  CONCLUSIONS
  The high expression of N-Cadherin in multiple myeloma may be one of the indicator for poor prognosis of MM, which may be related with 1q21 amplification.
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China. E-mail: majie318@163.com.cn.
authors: Jie
authors: J
authors: Ma
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Qing-Feng
authors: QF
authors: Yu
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Xiao-Yan
authors: XY
authors: Liu
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Chong
authors: C
authors: Wang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Qiu-Tang
authors: QT
authors: Zhang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Si-Lin
authors: SL
authors: Gan
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Sheng-Mei
authors: SM
authors: Chen
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Xin-Sheng
authors: XS
authors: Xie
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Yan-Fang
authors: YF
authors: Liu
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Lin-Xiang
authors: LX
authors: Liu
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Ding-Ming
authors: DM
authors: Wan
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Hui
authors: H
authors: Sun
mesh_terms: D001853:Bone Marrow; D001842:Bone and Bones; D015820:Cadherins; D005434:Flow Cytometry; D006801:Humans; D009101:Multiple Myeloma
chemical_list: D015820:Cadherins