title: Uric acid correlates to oxidation and inflammation in opposite directions in women.
abstract: OBJECTIVE
  To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.
  
  
  METHODS
  Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.
  
  
  RESULTS
  Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine.
  
  
  CONCLUSIONS
  Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.
authors: a Department of Medicine, Division of Epidemiology , Vanderbilt University Medical Center , Nashville , TN , USA .
authors: Sheng Hui
authors: SH
authors: Wu
authors: Xiao Ou
authors: XO
authors: Shu
authors: Ginger
authors: G
authors: Milne
authors: Yong-Bing
authors: YB
authors: Xiang
authors: Xianglan
authors: X
authors: Zhang
authors: Qiuyin
authors: Q
authors: Cai
authors: Sergio
authors: S
authors: Fazio
authors: MacRae F
authors: MF
authors: Linton
authors: Honglei
authors: H
authors: Chen
authors: Mark
authors: M
authors: Purdue
authors: Nathaniel
authors: N
authors: Rothman
authors: Yu-Tang
authors: YT
authors: Gao
authors: Wei
authors: W
authors: Zheng
authors: Gong
authors: G
authors: Yang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000652:urine*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D002853:Chromatography, Liquid; D028441:F2-Isoprostanes / Q000652:urine; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000652:urine*; D018836:Inflammation Mediators / Q000097:blood / Q000652:urine*; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D053719:Tandem Mass Spectrometry; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D028441:F2-Isoprostanes; D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D014527:Uric Acid; D002097:C-Reactive Protein
keywords: Biomarker; inflammation; oxidative stress; uric acid