title: The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity.
abstract: Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor.
authors: Department of Traumatology and Sports Injuries, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University Salzburg Salzburg, Austria.
authors: Stephanie
authors: S
authors: Wallner
authors: Department of Neurology, University Hospital Regensburg Regensburg, Germany.
authors: Sebastian
authors: S
authors: Peters
authors: Interdisciplinary Neurobehavioral Core, Ruprecht-Karls-University Heidelberg, Germany.
authors: Claudia
authors: C
authors: Pitzer
authors: Department of Traumatology and Sports Injuries, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University Salzburg Salzburg, Austria ; University Clinic of Traumatology and Sports Injuries Salzburg, Paracelsus Medical University Salzburg Salzburg, Austria.
authors: Herbert
authors: H
authors: Resch
authors: Department of Neurology, University Hospital Regensburg Regensburg, Germany.
authors: Ulrich
authors: U
authors: Bogdahn
authors: SYGNIS Bioscience GmbH Heidelberg, Germany.
authors: Armin
authors: A
authors: Schneider
keywords: ALS; G-CSF; SCI; angiogenesis; arteriogenesis; neurogenesis; neuroregeneration; plasticity