title: The effects of baicalein and baicalin on mitochondrial function and dynamics: A review.
abstract: Mitochondria play an essential role in cell survival by providing energy, calcium buffering, and regulating apoptosis. A growing body of evidence shows that mitochondrial dysfunction and its consequences, including impairment of the mitochondrial respiratory chain, excessive generation of reactive oxygen species, and excitotoxicity, play a pivotal role in the pathogenesis of different diseases such as neurodegenerative diseases, neuropsychiatric disorders, and cancer. The therapeutical role of flavonoids on these diseases is gaining increasing acceptance. Numerous studies on experimental models have revealed the favorable role of flavonoids on mitochondrial function and structure. This review highlights the promising role of baicalin and its aglycone form, baicalein, on mitochondrial function and structure with a focus on its therapeutic effects. We also discuss their chemistry, sources and bioavailability.
authors: Department of Chemistry, ICET, Federal University of Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, CEP 78060-900 Cuiabá, MT, Brazil. Electronic address: mrobioq@yahoo.com.br.
authors: Marcos Roberto
authors: MR
authors: de Oliveira
authors: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors: Seyed Fazel
authors: SF
authors: Nabavi
authors: Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Central Avenue, Chatham-Maritime, Kent ME4 4TB, UK.
authors: Solomon
authors: S
authors: Habtemariam
authors: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
authors: Ilkay
authors: I
authors: Erdogan Orhan
authors: Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy.
authors: Maria
authors: M
authors: Daglia
authors: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.
authors: Seyed Mohammad
authors: SM
authors: Nabavi
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D044950:Flavanones / Q000627:therapeutic use*; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*
chemical_list: D044950:Flavanones; D005419:Flavonoids; C038044:baicalin; C006680:baicalein
keywords: Antioxidant; Baicalein; Baicalin; Flavonoid; Mitochondria