title: [Pheochromocytoma and paraganglioma].
abstract: Pheochromocytoma and functional paraganglioma (PH/PGL) are classical causes of secondary hypertension. The clinical practice guidelines for PH/PGL have been changed by the recent identification of a dozen of susceptibility genes. PH/PGL is the neuroendocrine tumor most affected by genetics. Total metanephrin should be measured in every young patient suffering of a resistant hypertension. The diagnosis is based on conventional imaging assciated with nuclear imaging. Genetic testing should be offered to every patient diagnosed for PH/PGL because the identification of a germline mutation, which is found in over 30% of the cases, will change his work-up and follow-up as well as offer the opportunity of a familial genetic testing in relatives. A specialized management is indicated, especially for patients with hereditary or metastatic PH/PGL, and should be performed in an expert center with a multidisciplinary team.
authors: Anne-Paule
authors: AP
authors: Gimenez-Roqueplo
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000628:therapy; D010235:Paraganglioma / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery