title: Epilepsy and bipolar disorder.
abstract: It is well recognized that mood disorders and epilepsy commonly co-occur. Despite this, our knowledge regarding the relationship between epilepsy and bipolar disorder is limited. Several shared features between the two disorders, such as their episodic nature and potential to run a chronic course, and the efficacy of some antiepileptic medications in the prophylaxis of both disorders, are often cited as evidence of possible shared underlying pathophysiology. The present paper aims to review the bidirectional associations between epilepsy and bipolar disorder, with a focus on epidemiological links, evidence for shared etiology, and the impact of these disorders on both the individual and wider society. Better recognition and understanding of these two complex disorders, along with an integrated clinical approach, are crucial for improved evaluation and management of comorbid epilepsy and mood disorders.
authors: MRC Centre for Neuropsychiatric Genetics and Genomics, Haydn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK. Electronic address: KnottS@cardiff.ac.uk.
authors: Sarah
authors: S
authors: Knott
authors: MRC Centre for Neuropsychiatric Genetics and Genomics, Haydn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK. Electronic address: FortyL@cardiff.ac.uk.
authors: Liz
authors: L
authors: Forty
authors: MRC Centre for Neuropsychiatric Genetics and Genomics, Haydn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK. Electronic address: CraddockN@cardiff.ac.uk.
authors: Nick
authors: N
authors: Craddock
authors: MRC Centre for Neuropsychiatric Genetics and Genomics, Haydn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK. Electronic address: ThomasRH5@cardiff.ac.uk.
authors: Rhys H
authors: RH
authors: Thomas
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000150:complications* / Q000235:genetics / Q000523:psychology; D004827:Epilepsy / Q000150:complications* / Q000235:genetics / Q000523:psychology; D006801:Humans
chemical_list: D000927:Anticonvulsants
keywords: Bipolar disorder; Comorbidity; Epilepsy; Genetics