title: Macrophage heterogeneity, phenotypes, and roles in renal fibrosis.
abstract: Macrophages (MΦ) are highly heterogeneous cells that exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. MΦ are distributed throughout normal and diseased kidney tissue, where they have been recognized as key factors in renal fibrosis. Recent studies have identified switch of phenotype and diverse roles for MΦ in several murine models of kidney disease. In this review, we discuss macrophage heterogeneity and their involvement in renal fibrosis.
authors: Centre for Transplant and Renal Research, Westmead Millennium Institute at University of Sydney , Sydney, New South Wales, Australia.
authors: Qi
authors: Q
authors: Cao
authors: Centre for Transplant and Renal Research, Westmead Millennium Institute at University of Sydney , Sydney, New South Wales, Australia.
authors: Yiping
authors: Y
authors: Wang
authors: Centre for Transplant and Renal Research, Westmead Millennium Institute at University of Sydney , Sydney, New South Wales, Australia.
authors: David C H
authors: DC
authors: Harris
keywords: effector; fibrosis; macrophages; regulatory