title: Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives.
abstract: New secondary benzenesulphonamide-substituted coumarylthiazole derivatives were synthesized and their inhibitory effects on purified carbonic anhydrase I and II were evaluated using CO2 as a substrate. The result showed that all the synthesized compounds exhibited inhibitory activity on both hCA I and hCA II with N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)naphthalene-2-sulphonamide (5f, IC50 value of 5.63 and 8.48 µM, against hCA I and hCA II, respectively) as the strongest inhibitor revealed from this study. Structure-activity relationship revealed that the inhibitory activity of the synthesized compounds is related to the type of the halogen and bulky substituent on the phenyl ring. In addition, the cupric reducing antioxidant capacities (CUPRAC) and ABTS cation radical scavenging abilities of the synthesized compounds were assayed. 4-methoxy-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)benzenesulphonamide (5e) exhibited the strongest ABTS and CUPRAC activity with IC50 value of 48.83 µM and A0.50 value of 23.29 µM, respectively.
authors: a Department of Medicinal Chemistry, Faculty of Pharmacy , Bezmialem Vakif University , Istanbul , Turkey .
authors: Belma Zengin
authors: BZ
authors: Kurt
authors: b Pamukova Vocational High School, Sakarya University , Sakarya , Turkey .
authors: Fatih
authors: F
authors: Sönmez
authors: c Department of Chemistry, Faculty of Art and Sciences , Balikesir University , Balikesir , Turkey , and.
authors: Çiğdem
authors: Ç
authors: Bilen
authors: c Department of Chemistry, Faculty of Art and Sciences , Balikesir University , Balikesir , Turkey , and.
authors: Adem
authors: A
authors: Ergun
authors: c Department of Chemistry, Faculty of Art and Sciences , Balikesir University , Balikesir , Turkey , and.
authors: Nahit
authors: N
authors: Gençer
authors: c Department of Chemistry, Faculty of Art and Sciences , Balikesir University , Balikesir , Turkey , and.
authors: Oktay
authors: O
authors: Arslan
authors: d Department of Chemistry, Faculty of Arts and Science , Sakarya University , Sakarya , Turkey.
authors: Mustafa
authors: M
authors: Kucukislamoglu
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors* / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013844:Thiazoles; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II
keywords: ABTS; CUPRAC; antioxidant; carbonic anhydrase; coumarin; sulphonamide