title: Clozapine intoxication due to cessation of smoking and infection.
abstract: We report on a patient on clozapine treatment who was admitted to our hospital with pneumonia. He had stopped smoking a few weeks before admission. The serum clozapine rose to a toxic level, most likely due to the combination of infection and smoking cessation. Physicians and pharmacists are often not aware of risk factors for decreased metabolism of clozapine.
authors: Department of Clinical Pharmacy, Deventer Hospital, Deventer, the Netherlands.
authors: E M
authors: EM
authors: ten Bokum
authors: H L A
authors: HL
authors: van de Oever
authors: D W S
authors: DW
authors: Radstake
authors: M E L
authors: ME
authors: Arbouw
mesh_terms: D014150:Antipsychotic Agents / Q000097:blood / Q000506:poisoning*; D003024:Clozapine / Q000097:blood / Q000506:poisoning*; D016724:Empyema, Pleural / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism; D016540:Smoking Cessation
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine