title: Nano-antioxidants: An emerging strategy for intervention against neurodegenerative conditions.
abstract: Oxidative stress has for long been linked to the neuronal cell death in many neurodegenerative conditions. Conventional antioxidant therapies have been less effective in preventing neuronal damage caused by oxidative stress due to their inability to cross the blood brain barrier. Nanoparticle antioxidants constitute a new wave of antioxidant therapies for prevention and treatment of diseases involving oxidative stress. It is believed that nanoparticle antioxidants have strong and persistent interactions with biomolecules and would be more effective against free radical induced damage. Nanoantioxidants include inorganic nanoparticles possessing intrinsic antioxidant properties, nanoparticles functionalized with antioxidants or antioxidant enzymes to function as an antioxidant delivery system. Nanoparticles containing antioxidants have shown promise as high-performance therapeutic nanomedicine in attenuating oxidative stress with potential applications in treating and preventing neurodegenerative conditions. However, to realize the full potential of nanoantioxidants, negative aspects associated with the use of nanoparticles need to be overcome to validate their long term applications.
authors: Department of Biochemistry, Panjab University, Chandigarh 160014, India. Electronic address: sandhir@pu.ac.in.
authors: Rajat
authors: R
authors: Sandhir
authors: Department of Biochemistry, Panjab University, Chandigarh 160014, India.
authors: Aarti
authors: A
authors: Yadav
authors: Department of Biochemistry, Panjab University, Chandigarh 160014, India.
authors: Aditya
authors: A
authors: Sunkaria
authors: National Agri-Food Biotechnology Institute, Mohali 160071, Punjab, India.
authors: Nitin
authors: N
authors: Singhal
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D016503:Drug Delivery Systems / Q000639:trends*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000517:prevention & control*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology
chemical_list: D000975:Antioxidants
keywords: Antioxidants; Blood brain barrier; Brain; Nanoantioxidants; Nanoparticles; Neurodegeneration