title: FUNCTIONAL LIMITATIONS AND ADIPOKINES IN HIV-INFECTED OLDER ADULTS.
abstract: BACKGROUND
  There is a significant increase in the number of HIV-infected older adults (HOA). This population may experience functional decline at a much younger age. Little is known about the relationship between functional limitations and systemic adipokines in HOA.
  
  
  OBJECTIVE
  Our study aimed to evaluate the relationship between functional limitations and systemic adipokine levels in HOA population.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Academic hospital-based infectious disease clinic.
  
  
  METHODS
  The study investigated community-dwelling HIV-infected adults >50 years old and compared this group with age, gender and BMI comparable healthy controls.
  
  
  METHODS
  We measured functional status, body composition and plasma concentrations of adipokines.
  
  
  RESULTS
  Fifty-four HOA were studied (mean: age 57 years, BMI 29 kg/m2, CD4 604, duration of HIV 17 years) and compared with thirty-two age, gender and BMI comparable healthy controls. The HOA group showed significantly higher functional limitations compared to the age, gender and BMI comparable controls (p<0.05). Levels of adipokines were significantly different between the two groups (p<0.05). Multiple regression analyses indicated that adiponectin and visfatin were significantly correlated with several physical function measures after controlling for age, sex, and metabolic comorbidities. Adiponectin was negatively correlated with functional limitations, and this relationship was stronger in the control group compared to the HOA group. Conversely, visfatin was positively correlated with functional limitations only in the HOA group.
  
  
  CONCLUSIONS
  HOA have significant functional limitations and alteration in adipokine levels compared to controls. Adiponectin and visfatin were associated with functional limitations. Visfatin was a correlate of physical function only in the HOA group. Prospective longitudinal studies could provide further insight on the role of adipokines in HIV-related functional decline.
authors: Division of Geriatrics and Aging, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
authors: K N
authors: KN
authors: Shah
authors: Division of Geriatrics and Aging, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
authors: Z
authors: Z
authors: Majeed
authors: Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
authors: H
authors: H
authors: Yang
authors: Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
authors: J J
authors: JJ
authors: Guido
authors: Department of Physical Therapy, Ithaca College, Rochester, New York.
authors: T N
authors: TN
authors: Hilton
authors: Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
authors: O
authors: O
authors: Polesskaya
authors: Division of Geriatrics and Aging, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
authors: W J
authors: WJ
authors: Hall
authors: Division of Infectious Disease, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
authors: A E
authors: AE
authors: Luque
keywords: HIV; adipokines; fat redistribution; older adults; physical function