title: Visceral adiposity is associated with an increased risk of functional dyspepsia.
abstract: BACKGROUND
  The relationship between visceral adiposity and the incidence of functional dyspepsia (FD) has not yet been studied. The purpose of the present study is to evaluate the association between visceral adiposity and the risk of FD.
  
  
  METHODS
  This is a case-control study that compares the abdominal adipose tissue area between subjects with FD and control subjects without FD, who underwent abdomen computerized tomography (CT) for health examinations in a tertiary center. Retrospectively, a telephone survey was conducted to diagnose FD using the Rome III criteria. We measured various indices of obesity including body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT) area, subcutaneous adipose tissue (SAT) area and the VAT/SAT ratio in order to evaluate the association between FD and abdominal adiposity.
  
  
  RESULTS
  A total of 363 subjects were included in the present study. FD was diagnosed in 90 subjects (24.8%). In the univariate analysis, WC, VAT area, TAT area, VAT/SAT ratio, and the presence of erosive esophagitis were significantly higher in the FD group than in the non-FD group. In the multivariate analysis, a higher VAT area (odds ratio (OR), 3.76; 95% confidence interval (CI), 1.24-11.40; highest quartile vs lowest quartile, p = 0.019) and VAT/SAT ratio (OR, 2.35; 95% CI, 1.27-4.32; highest quartile vs lowest quartile, p = 0.006) were independently associated with a risk of FD.
  
  
  CONCLUSIONS
  Visceral adiposity as measured by the VAT area and VAT/SAT ratio is associated with an increased risk of FD.
authors: Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea.|Department of Internal Medicine, Incheon Sarang Hospital, Incheon, Republic of Korea.
authors: Jae Gu
authors: JG
authors: Jung
authors: Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea.
authors: Jae Nam
authors: JN
authors: Yang
authors: Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea.
authors: Chang Geun
authors: CG
authors: Lee
authors: Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea.
authors: Sung Hun
authors: SH
authors: Choi
authors: Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea.
authors: Won Gun
authors: WG
authors: Kwack
authors: Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea.
authors: Jin Ho
authors: JH
authors: Lee
authors: Department of Internal Medicine, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea.
authors: Hyoun Woo
authors: HW
authors: Kang
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015992:Body Mass Index; D016022:Case-Control Studies; D004415:Dyspepsia / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications* / Q000175:diagnosis; D012306:Risk; D050151:Subcutaneous Fat / Q000473:pathology; D055105:Waist Circumference
keywords: functional dyspepsia; gastrointestinal diseases; visceral adiposity