title: [Influence of limk1 Gene Polymorphism on Learning Acquisition and Memory Formation with pCREB Distribution and Aggregate Formation in Neuromuscular Junctions in Drosophila melanogaster].
abstract: We have shown previously that the polymorphic structure of the limk1 gene in drosophila leads to changes in LIMK1 content and to defects in courtship behavior, sound production, and learning/memory. The results of the present study of three wild-type strains and mutant agn(ts3) with altered limk1 structure demonstrate that long-term memory is normal in Canton-S and Oregon-R but is impaired in Berlin and drastically suppressed in agn(ts3). This temperature-sensitive mutant carries the S-element from the Tc1/mariner family insertion near the dlimk1 3'-UTR and, compared to Canton-S, has a reverse pCREB distribution in adult neuromuscular junctions (NMJ) of the second dorsal imago nerve before and after learning. Moreover, only agn(ts3) demonstrates amyloid-like aggregate formation in NMJ. This suggests that this impedes pCREb transport and thereby impairs the formation of short- and long-term memory.
authors: A N
authors: AN
authors: Kaminskaya
authors: E A
authors: EA
authors: Nikitina
authors: A V
authors: AV
authors: Medvedeva
authors: M S
authors: MS
authors: Gerasimenko
authors: D A
authors: DA
authors: Chernikova
authors: E V
authors: EV
authors: Savateeva-Popova
mesh_terms: D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D054461:Lim Kinases / Q000235:genetics*; D008568:Memory; D009469:Neuromuscular Junction / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D066329:Protein Aggregates
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D029721:Drosophila Proteins; D066329:Protein Aggregates; D054461:Lim Kinases; C000599872:limk1 protein, Drosophila