title: Chirality sensing with stereodynamic biphenolate zinc complexes.
abstract: Two bidentate ligands consisting of a fluxional polyarylacetylene framework with terminal phenol groups were synthesized. Reaction with diethylzinc gives stereodynamic complexes that undergo distinct asymmetric transformation of the first kind upon binding of chiral amines and amino alcohols. The substrate-to-ligand chirality imprinting at the zinc coordination sphere results in characteristic circular dichroism signals that can be used for direct enantiomeric excess (ee) analysis. This chemosensing approach bears potential for high-throughput ee screening with small sample amounts and reduced solvent waste compared to traditional high-performance liquid chromatography methods.
authors: Department of Chemistry, Georgetown University, Washington, D.C.
authors: Keith W
authors: KW
authors: Bentley
authors: Department of Chemistry, Georgetown University, Washington, D.C.
authors: Zeus A
authors: ZA
authors: de Los Santos
authors: Department of Chemistry, Georgetown University, Washington, D.C.
authors: Mary J
authors: MJ
authors: Weiss
authors: Department of Chemistry, Georgetown University, Washington, D.C.
authors: Christian
authors: C
authors: Wolf
keywords: chemosensor; chiral amplification; circular dichroism; enantioselective analysis; stereolabile zinc complex