title: Three-Dimensional Cu Foam-Supported Single Crystalline Mesoporous Cu2O Nanothorn Arrays for Ultra-Highly Sensitive and Efficient Nonenzymatic Detection of Glucose.
abstract: Highly sensitive and efficient biosensors play a crucial role in clinical, environmental, industrial, and agricultural applications, and tremendous efforts have been dedicated to advanced electrode materials with superior electrochemical activities and low cost. Here, we report a three-dimensional binder-free Cu foam-supported Cu2O nanothorn array electrode developed via facile electrochemistry. The nanothorns growing in situ along the specific direction of <011> have single crystalline features and a mesoporous surface. When being used as a potential biosensor for nonenzyme glucose detection, the hybrid electrode exhibits multistage linear detection ranges with ultrahigh sensitivities (maximum of 97.9 mA mM(-1) cm(-2)) and an ultralow detection limit of 5 nM. Furthermore, the electrode presents outstanding selectivity and stability toward glucose detection. The distinguished performances endow this novel electrode with powerful reliability for analyzing human serum samples. These unprecedented sensing characteristics could be ascribed to the synergistic action of superior electrochemical catalytic activity of nanothorn arrays with dramatically enhanced surface area and intimate contact between the active material (Cu2O) and current collector (Cu foam), concurrently supplying good conductivity for electron/ion transport during glucose biosensing. Significantly, our findings could guide the fabrication of new metal oxide nanostructures with well-organized morphologies and unique properties as well as low materials cost.
authors: Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University , Jingshi Road 17923, Jinan 250061, P. R. China.
authors: Chaoqun
authors: C
authors: Dong
authors: Dermatological Department, Qilu Hospital of Shandong University , Jinan Culture Road 107, Jinan 250012, P. R. China.
authors: Hua
authors: H
authors: Zhong
authors: Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University , Jingshi Road 17923, Jinan 250061, P. R. China.
authors: Tianyi
authors: T
authors: Kou
authors: Institut für Werkstoffe, Ruhr Universität Bochum , Bochum 44780, Germany.
authors: Jan
authors: J
authors: Frenzel
authors: Institut für Werkstoffe, Ruhr Universität Bochum , Bochum 44780, Germany.
authors: Gunther
authors: G
authors: Eggeler
authors: Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University , Jingshi Road 17923, Jinan 250061, P. R. China.
authors: Zhonghua
authors: Z
authors: Zhang
mesh_terms: D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D046228:Microarray Analysis; D049329:Nanostructures / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D001786:Blood Glucose; D003300:Copper; C030973:cupric oxide
keywords: biosensors; catalysis; hybrid materials; nanostructures; nanothorn arrays