title: A systematic review of computed tomography detection of cartilage invasion in laryngeal carcinoma.
abstract: OBJECTIVE
  This systematic review aimed to assess the diagnostic value of computed tomography (CT) in detecting cartilage invasion among patients with laryngeal carcinoma.
  
  
  METHODS
  PubMed, Embase, and the Cochrane Library.
  
  
  METHODS
  A search in the previously mentioned databases was performed to identify relevant articles. Articles comparing cartilage invasion on CT with histology were selected. After critical appraisal, articles of adequate relevance and validity were included in further analysis. Prevalences, sensitivity, specificity, positive predictive values, and negative predictive values were extracted from the included articles.
  
  
  RESULTS
  Four studies were included in the final analysis. Only one study examined the positive predictive value and negative predictive value for invasion of any laryngeal cartilage, and they were 87% and 56%, respectively. The positive predictive value and negative predictive value for thyroid cartilage invasion were investigated in three studies and ranged from 44% to 80% and from 85% to 100%, respectively. The negative predictive value is likely underestimated due to selection bias, whereas the positive predictive value is likely overestimated.
  
  
  CONCLUSIONS
  CT imaging is a suitable tool to assess laryngeal cartilage invasion, especially regarding the thyroid cartilage.
authors: Anda P J
authors: AP
authors: Adolphs
authors: Nienke A
authors: NA
authors: Boersma
authors: Babette D M
authors: BD
authors: Diemel
authors: Joep E C
authors: JE
authors: Eding
authors: Francien E
authors: FE
authors: Flokstra
authors: Inge
authors: I
authors: Wegner
authors: Wilko
authors: W
authors: Grolman
authors: Weibel
authors: W
authors: Braunius
mesh_terms: D006801:Humans; D007817:Laryngeal Cartilages / Q000000981:diagnostic imaging* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D009361:Neoplasm Invasiveness; D014057:Tomography, X-Ray Computed / Q000379:methods*