title: Centrosome positioning in non-dividing cells.
abstract: Centrioles and centrosomes are found in almost all eukaryotic cells, where they are important for organising the microtubule cytoskeleton in both dividing and non-dividing cells. The spatial location of centrioles and centrosomes is tightly controlled and, in non-dividing cells, plays an important part in cell migration, ciliogenesis and immune cell functions. Here, we examine some of the ways that centrosomes are connected to other organelles and how this impacts on cilium formation, cell migration and immune cell function in metazoan cells.
authors: Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK.|Centre for Microvascular Research, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London.
authors: Amy R
authors: AR
authors: Barker
authors: Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK.
authors: Kate V
authors: KV
authors: McIntosh
authors: Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK. h.r.dawe@exeter.ac.uk.
authors: Helen R
authors: HR
authors: Dawe
mesh_terms: D000818:Animals; D002465:Cell Movement; D002467:Cell Nucleus / Q000502:physiology / Q000648:ultrastructure; D016764:Cell Polarity; D018385:Centrosome / Q000502:physiology* / Q000648:ultrastructure; D002923:Cilia / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology / Q000648:ultrastructure; D006801:Humans
keywords: Centriole; Centrosome; Cilium; Immunological synapse; Migration