title: [Evaluating the effectiveness of Solanum tuberosum shoots extract in experimental ocular herpes].
abstract: Ocular herpes (OH) is an infectious disease caused by the herpes simplex virus (HSV) characterized by a variable clinical presentation and often accompanied by complications that may lead to deterioration of visual functions, cataract development, or even blindness. Its treatment is arduous. The aim of this work was to evaluate the effectiveness, tolerability, and safety of Panavir eye drops in a rabbit model of OH.
  
  
  METHODS
  Ocular infection was induced with HSV-1 (EU strain) in grey rabbits (all males, 2.5-3.0 kg) according to the standard technique. The treatment included Panavir-GLA (Panavir-gamma-linolenic acid) and Panavir medications.
  
  
  RESULTS
  Panavir eye drops instilled 6 times daily for 8 days showed a pronounced therapeutic effect and prevented the development of severe corneal opacities. The most rapid and significant results were seen in rabbits with epithelial keratitis and those with short-term persistence of the virus. Generally, the effectiveness of Panavir eye drops was comparable with that of the reference drug (Oftalmoferon). Panavir instillations caused no irritation, toxic and/or allergic effects and were well tolerated by the rabbits.
  
  
  CONCLUSIONS
  The data obtained suggest that Panavir eye drops may be included in OH treatment schemes.
authors: Research Institute of Virology named after D.I. Ivanovsky, Ministry of Health of the Russian Federation, 16 Gamalei St., Moscow, Russian Federation, 123098.
authors: L M
authors: LM
authors: Alimbarova
authors: Research Institute of Virology named after D.I. Ivanovsky, Ministry of Health of the Russian Federation, 16 Gamalei St., Moscow, Russian Federation, 123098.
authors: A A
authors: AA
authors: Lazarenko
authors: Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russian Federation, 119991.
authors: A V
authors: AV
authors: Kiselev
authors: Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russian Federation, 119991.
authors: E V
authors: EV
authors: Stovbun
authors: Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russian Federation, 119991.
authors: M I
authors: MI
authors: Bagaeva
authors: Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russian Federation, 119991.
authors: E V
authors: EV
authors: Petryanina
mesh_terms: D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000473:pathology / Q000821:virology; D004195:Disease Models, Animal; D016849:Keratitis, Herpetic / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D008297:Male; D009883:Ophthalmic Solutions; D008517:Phytotherapy / Q000379:methods*; D028321:Plant Preparations / Q000008:administration & dosage*; D011817:Rabbits; D018139:Simplexvirus / Q000302:isolation & purification*; D011198:Solanum tuberosum
chemical_list: D009883:Ophthalmic Solutions; D028321:Plant Preparations