title: Neurofilament Accumulation in Rabbit Retinas.
abstract: An eosinophilic body (EB) was observed in the inner nuclear layer and the outer plexiform layer of the anterior dorsal region of the retina in New Zealand White, Japanese White and Dutch rabbits. Immunohistochemistry confirmed that the EB was an accumulation of neurofilaments (NFs). Ultrastructurally, intermediate filaments of approximately 10 nm in diameter were observed in the EB, but there were no intracellular organelles. These results suggested that the NFs had accumulated in the neurites of the horizontal cells in the retina. This is the first description of a new pattern of NF accumulation in the mammalian retina. The prevalence of the EBs increased significantly in 44-56-week-old male Dutch rabbits (38.9 %) compared with 18-23-week-old (12.9 %) rabbits, suggesting that the formation of EBs in the rabbit retina could be an age-related change.
authors: Pathology Department, Nonclinical Research Center, Drug Development Service Segment, LSI Medicine Corporation, 1285 Kurisaki-machi, Uto, Kumamoto, Japan. Electronic address: kawasako.kazufumi@mx.medience.co.jp.
authors: K
authors: K
authors: Kawasako
authors: Pathology Department, Nonclinical Research Center, Drug Development Service Segment, LSI Medicine Corporation, 1285 Kurisaki-machi, Uto, Kumamoto, Japan.
authors: T
authors: T
authors: Oshikata
authors: Pathology Department, Nonclinical Research Center, Drug Development Service Segment, LSI Medicine Corporation, 1285 Kurisaki-machi, Uto, Kumamoto, Japan.
authors: T
authors: T
authors: Kanno
authors: Pathology Department, Nonclinical Research Center, Drug Development Service Segment, LSI Medicine Corporation, 1285 Kurisaki-machi, Uto, Kumamoto, Japan.
authors: M
authors: M
authors: Hamamura
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000648:ultrastructure*; D008297:Male; D046529:Microscopy, Electron, Transmission; D011817:Rabbits; D012160:Retina / Q000648:ultrastructure*
keywords: eosinophilic body; neurofilaments; rabbit; retina