title: Schizophrenia Research: A Progress Report.
abstract: This overview highlights the current hot topics in schizophrenia research. One major drawback to progress is the ability to define and focus on the right patient group. Schizophrenia is a biased and heterogeneous (group of) condition(s), the boundaries of which remain uncertain. An initiative that will focus attention away from (mere) symptoms of the illness and toward its underlying neurobiological construct(s) is the Research Domain Criteria. A preliminary analysis from a large neurobiological study suggests that 3 distinct biological phenotypes underlie the clinical expression of 1 major psychosis. A firmer neurobiologically based foundation is needed to advance this field.
authors: Medical College of Georgia, Georgia Regents University, 1120 15th Street, AA-1006, Augusta, GA 30912, USA. Electronic address: pbuckley@gru.edu.
authors: Peter F
authors: PF
authors: Buckley
authors: Department of Psychiatry, Georgia Regents University, 1120 15th Street, AA-1006, Augusta, GA 30912, USA.
authors: Brian J
authors: BJ
authors: Miller
mesh_terms: D000069586:Adult Survivors of Child Adverse Events / Q000523:psychology*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000453:epidemiology*; D015507:Drugs, Investigational / Q000627:therapeutic use; D061345:Early Medical Intervention; D055106:Genome-Wide Association Study; D006801:Humans; D044968:Regenerative Medicine; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D015507:Drugs, Investigational
keywords: Antipsychotics; Autoimmune diseases; Early intervention; Head trauma; Regenerative medicine; Research discoveries; Schizophrenia; Treatment approaches