title: Left ventricular structural and functional abnormalities in dogs with hyperadrenocorticism.
abstract: OBJECTIVE
  Hyperadrenocorticism has been reported to cause left ventricular (LV) structural and functional abnormalities in human patients. The purpose of the present study was to assess the incidence and features of LV structural and functional changes in dogs with hyperadrenocorticism.
  
  
  METHODS
  Twenty-two client-owned dogs with pituitary-dependent hyperadrenocorticism (n = 15) and cortisol-secreting adrenocortical tumors (n = 7) and 6 control dogs were enrolled in this study.
  
  
  METHODS
  Echocardiographic examinations were performed and non-invasive measurements of systolic blood pressure (SBP) were obtained.
  
  
  RESULTS
  The normalized LV wall thickness and LV mass index of the affected dogs differed significantly from those of control dogs. Using a published reference value for M-mode measurements, 15 of the 22 dogs (68%) were found to have increased LV wall thickness. Eleven of the 15 (73%) dogs with increased LV wall thickness were normotensive, and no significant correlation between LV wall thickness and SBP was found.
  
  
  CONCLUSIONS
  Regardless of the presence of systemic hypertension, hyperadrenocorticism should be included in the differential diagnosis of underlying disorders that may cause LV hypertrophy in dogs.
authors: Department of Surgery 1, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuoku, Sagamihara, Kanagawa 252-5201, Japan. Electronic address: takano-in-loanhead@hotmail.com.
authors: Hiroshi
authors: H
authors: Takano
authors: Department of Surgery 1, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuoku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Akira
authors: A
authors: Kokubu
authors: Department of Surgery 1, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuoku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Keisuke
authors: K
authors: Sugimoto
authors: Department of Surgery 1, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuoku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Hiroshi
authors: H
authors: Sunahara
authors: Department of Surgery 1, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuoku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Takuma
authors: T
authors: Aoki
authors: Department of Surgery 1, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuoku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Yoko
authors: Y
authors: Fijii
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000662:veterinary; D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000662:veterinary*; D000818:Animals; D016022:Case-Control Studies; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D006352:Heart Ventricles / Q000473:pathology*; D006973:Hypertension / Q000662:veterinary; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000662:veterinary*
keywords: Canine; Concentric; Cushing's; Hypertrophy