title: Atypical Findings on Cervicovaginal Smears Correlate with Cervical Involvement by Malignant Mixed Müllerian Tumors of the Uterus.
abstract: OBJECTIVE
  A malignant mixed müllerian tumor (MMMT) is a high-grade neoplasm commonly arising from the uterus. Patients present with bleeding and a mass protruding from the cervix. This study was designed to correlate Papanicolaou (Pap) smear findings with histological findings in women diagnosed with MMMT.
  
  
  METHODS
  Women diagnosed with MMMT were identified. Preoperative Pap tests were correlated with histological findings. Statistical analysis was performed to assess associations between abnormal Pap tests and histological findings.
  
  
  RESULTS
  Forty patients with MMMT were included in the study. Age ranged from 37-85 years and tumor size ranged from 1.2 to 21 cm. In presurgical Pap tests (4 conventional and 36 liquid based), 11 smears (27.5%) were diagnosed as negative, 5 (12.5%) as atypical squamous cells of undetermined significance, 6 (15%) as atypical glandular cells, 16 (40%) as malignant and 2 (5%) as high-grade squamous intraepithelial lesion. Malignant cells detected on Pap smears showed a strong correlation with endocervical involvement by MMMT (p = 0.002). Larger tumors were more likely to involve the cervix (p = 0.0115).
  
  
  CONCLUSIONS
  The Pap test can predict cervical involvement by MMMT. On Pap smears, MMMT cells showed no correlation with other adverse histological features (lymphovascular invasion, myoinvasion or adnexal involvement).
authors: Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Ga., USA.
authors: Krisztina Z
authors: KZ
authors: Hanley
authors: Gabriela
authors: G
authors: Oprea-Ilies
authors: Claudia
authors: C
authors: Ormenisan
authors: Shabnam
authors: S
authors: Seydafkan
authors: Marina B
authors: MB
authors: Mosunjac
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018198:Mixed Tumor, Malignant / Q000175:diagnosis* / Q000473:pathology*; D065006:Papanicolaou Test / Q000379:methods; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D014599:Uterus / Q000473:pathology*