title: Imaging in pleural mesothelioma: A review of the 12th International Conference of the International Mesothelioma Interest Group.
abstract: Imaging of malignant pleural mesothelioma is essential to patient management, prognostication, and response assessment. From animal models to clinical trials, the gamut of research activities and clinical standards relies on imaging to provide information on lesion morphology and the growing number of physiologic characteristics amenable to capture through imaging techniques. The complex morphology, growth pattern, and biological mechanisms of mesothelioma, however, present challenges for image acquisition and interpretation. Nevertheless, novel approaches to image acquisition and subsequent image analysis have expanded the opportunities for (as well as the need for) imaging in this disease. This paper summarizes the imaging-based research presented orally at the 2014 International Conference of the International Mesothelioma Interest Group (iMig) in Cape Town, South Africa, October 2014. Presented topics include the imaging of hypoxia in a murine model through positron emission tomography (PET), the use of diffusion-weighted magnetic resonance imaging (MRI) to assess the histologic composition of biphasic mesothelioma and to assess early response to chemotherapy, the correlation of CT-based tumor volume with the volume of the post-surgical tumor specimen, the development of volumetric tumor response criteria, and pre-treatment tumor volume growth considerations for tumor response assessment.
authors: Department of Radiology, The University of Chicago, Chicago, IL, USA.
authors: Samuel G
authors: SG
authors: Armato
authors: Department of Radiology, University Hospitals, Leuven, Belgium.
authors: Johan
authors: J
authors: Coolen
authors: School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
authors: Anna K
authors: AK
authors: Nowak
authors: Molecular Anatomical Pathology, PathWest, QEII Medical Centre, Nedlands, Western Australia, Australia; School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
authors: Cleo
authors: C
authors: Robinson
authors: Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
authors: Ritu R
authors: RR
authors: Gill
authors: Department of Radiology, The University of Chicago, Chicago, IL, USA.
authors: Christopher
authors: C
authors: Straus
authors: Department of Radiology, The University of Chicago, Chicago, IL, USA.
authors: Ashoke
authors: A
authors: Khanwalkar
mesh_terms: D000818:Animals; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008654:Mesothelioma / Q000473:pathology*; D000086002:Mesothelioma, Malignant; D010997:Pleural Neoplasms / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D047368:Tumor Burden / Q000502:physiology
keywords: Apparent diffusion coefficient; Diffusion-weighted MRI; F-MISO; Mesothelioma; PET/CT; Pre-clinical imaging; Tumor histology; Tumor hypoxia; Tumor response assessment; Tumor response criteria; Tumor volume; Tumor volume growth rate