title: Role of Chemokines in Non-Small Cell Lung Cancer: Angiogenesis and Inflammation.
abstract: Non-small cell lung cancer (NSCLC) is one of the most common types of aggressive cancer. The tumor tissue, which shows an active angiogenesis, is composed of neoplastic and stromal cells, and an abundant inflammatory infiltrate. Angiogenesis is important to support tumor growth, while infiltrating cells contribute to the tumor microenvironment through the secretion of growth factors, cytokines and chemokines, important molecules in the progression of the disease. Chemokines are important in development, activation of the immune response, and physiological angiogenesis. Chemokines have emerged as important regulators in the pathophysiology of cancer. These molecules are involved in the angiogenesis/angiostasis balance and in the recruitment of tumor infiltrating hematopoietic cells. In addition, chemokines promote tumor cell survival, as well as the directing and establishment of tumor cells to metastasis sites. The findings summarized here emphasize the central role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in the inflammatory process of NSCLC angiogenesis.
authors: 1. Department of Biochemistry Research, National Institute of Respiratory Diseases "Ismael Cosío Villegas", Mexico City, Mexico.
authors: Selma
authors: S
authors: Rivas-Fuentes
authors: 2. Laboratory of Research on Rheumatic Diseases, National Institute of Respiratory Diseases "Ismael Cosío Villegas", Mexico City, Mexico.
authors: Alfonso
authors: A
authors: Salgado-Aguayo
authors: 3. Department of Comparative Biology, Faculty of Sciences, National Autonomous University of Mexico, Mexico City, Mexico.
authors: Silvana
authors: S
authors: Pertuz Belloso
authors: 1. Department of Biochemistry Research, National Institute of Respiratory Diseases "Ismael Cosío Villegas", Mexico City, Mexico.
authors: Patricia
authors: P
authors: Gorocica Rosete
authors: 1. Department of Biochemistry Research, National Institute of Respiratory Diseases "Ismael Cosío Villegas", Mexico City, Mexico.
authors: Noé
authors: N
authors: Alvarado-Vásquez
authors: 4. Laboratory of Research on Genomics, Genetics and Bioinformatics. Tower of Haemato-oncology, Children´s Hospital of Mexico "Federico Gomez", Mexico City, Mexico.
authors: Guillermo
authors: G
authors: Aquino-Jarquin
keywords: Chemokines; angiogenesis; cytokines; inflammation; non-small cell lung cancer.