title: Effects of Fuzheng Paidu tablet on peripheral blood T lymphocytes, intestinal mucosa T lymphocytes, and immune organs in cyclophosphamide-induced immunosuppressed mice.
abstract: OBJECTIVE
  The aim of this study is to investigate the effects of a Fuzheng Paidu tablet on peripheral blood T lymphocytes, intestinal mucosa T lymphocytes, and immune organs in cyclophosphamide (CY)-induced immunosuppressed mice.
  
  
  METHODS
  The experimental mice (but not the control mice) were intraperitoneally injected with 80 mg/kg of CY solution every day for 3 consecutive days. Meanwhile, each mouse was administered with corresponding drugs for 7 continuous days. Then, 1 h after the last administration, each index was detected.
  
  
  RESULTS
  The Fuzheng Paidu tablet significantly increases the CD4+/CD8+ ratio (P < 0.01) and the number of CD3+ and CD4+ cells in immunosuppressed mice (P < 0.01). In addition, the tablet apparently enhances the CD3+, CD4+, and CD8+ levels in the intestinal mucosal immune system (P < 0.01) as well as reverses the reduction of spleen lymphoid nodules and lymphocytes (P < 0.01). It also significantly improves intestinal inflammation, thymic atrophy, and sparse thymocytes in immunosuppressed mice (P < 0.01).
  
  
  CONCLUSIONS
  The Fuzheng Paidu tablet greatly increases the levels of peripheral blood T lymphocytes and intestinal mucosal T lymphocytes as well as improves atrophied thymuses and spleens in CY-induced immunosuppressed mice.
authors: a Henan University of Traditional Chinese Medicine ; Zhengzhou City , Henan Province , China.
authors: Mingsan
authors: M
authors: Miao
authors: a Henan University of Traditional Chinese Medicine ; Zhengzhou City , Henan Province , China.
authors: Bolin
authors: B
authors: Cheng
authors: a Henan University of Traditional Chinese Medicine ; Zhengzhou City , Henan Province , China.
authors: Lin
authors: L
authors: Guo
authors: a Henan University of Traditional Chinese Medicine ; Zhengzhou City , Henan Province , China.
authors: Jingjing
authors: J
authors: Shi
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D001769:Blood / Q000276:immunology*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D007155:Immunologic Factors / Q000008:administration & dosage*; D007413:Intestinal Mucosa / Q000276:immunology*; D008297:Male; D051379:Mice; D013154:Spleen / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects*; D013607:Tablets / Q000008:administration & dosage; D013950:Thymus Gland / Q000276:immunology
chemical_list: D004365:Drugs, Chinese Herbal; D007155:Immunologic Factors; D013607:Tablets; D003520:Cyclophosphamide
keywords: Fuzheng Paidu tablet; asymptomatic HIV infection; cyclophosphamide