title: Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.
abstract: A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.
authors: Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Mary M
authors: MM
authors: Nguyen
authors: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Andrea S
authors: AS
authors: Carlini
authors: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Miao-Ping
authors: MP
authors: Chien
authors: Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Sonya
authors: S
authors: Sonnenberg
authors: Department of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Colin
authors: C
authors: Luo
authors: Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Rebecca L
authors: RL
authors: Braden
authors: Animal Care Program, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Kent G
authors: KG
authors: Osborn
authors: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Yiwen
authors: Y
authors: Li
authors: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Nathan C
authors: NC
authors: Gianneschi
authors: Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
authors: Karen L
authors: KL
authors: Christman
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D000067493:Dynamic Light Scattering; D005453:Fluorescence; D006321:Heart / Q000187:drug effects*; D057927:Hydrophobic and Hydrophilic Interactions; D007275:Injections, Intravenous; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008823:Micelles; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D051381:Rats; D013997:Time Factors
chemical_list: D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D020778:Matrix Metalloproteinase 2; C522363:Mmp2 protein, rat; D020780:Matrix Metalloproteinase 9; C572337:Mmp9 protein, rat
keywords: MMPs; enzyme-responsive; intravenous injection; myocardial infarction; nanoparticles