title: BK Virus Nephropathy in Kidney Transplantation: An Approach Proposal and Update on Risk Factors, Diagnosis, and Treatment.
abstract: BK virus belongs to Polyomaviridae family; it causes 95% of nephropathy cases related to polyomavirus, with the other 5% caused by JC virus. Nephropathy jeopardizes graft function, causing a premature failure of the graft in 1%-10% of patients with kidney transplants. Nowadays, antiviral effective treatment is unknown, which is why blood and urine screening of renal transplantation patients has become the most important recommendation to guide the decrease of immunosuppression, and the only proven method to decrease poor outcomes. Different interventions, such as cidofovir, leflunomide, fluoroquinolones, and intravenous immunoglobulin, have been attempted with no improvement at all. This review aims to summarize the most relevant features of BK virus, historical issues, transmission mechanisms, risk factors, and therapeutic interventions.
authors: Organ and Tissues Transplant Group, Surgery Department, Medical School, National University of Colombia, Bogotá, Colombia. Electronic address: sg.velez@gmail.com.
authors: S
authors: S
authors: Gonzalez
authors: Organ and Tissues Transplant Group, Surgery Department, Medical School, National University of Colombia, Bogotá, Colombia.
authors: D P
authors: DP
authors: Escobar-Serna
authors: Organ and Tissues Transplant Group, Surgery Department, Medical School, National University of Colombia, Bogotá, Colombia.
authors: O
authors: O
authors: Suarez
authors: Organ and Tissues Transplant Group, Surgery Department, Medical School, National University of Colombia, Bogotá, Colombia.
authors: X
authors: X
authors: Benavides
authors: Internal Medicine and Critical Care, Universidad de Antioquia, Medellín, Colombia.
authors: J F
authors: JF
authors: Escobar-Serna
authors: Organ and Tissues Transplant Group, Surgery Department, Medical School, National University of Colombia, Bogotá, Colombia; Hospital Universitario San Ignacio, Bogotá, Colombia.
authors: E
authors: E
authors: Lozano
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D016030:Kidney Transplantation / Q000009:adverse effects*; D027601:Polyomavirus Infections / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D012307:Risk Factors; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000628:therapy / Q000821:virology
chemical_list: D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous