title: Classic Studies on the Potential of Stem Cell Neuroregeneration.
abstract: The 1990s and 2000s were the beginning of an exciting time period for developmental neuroscience and neural stem cell research. By better understanding brain plasticity and the birth of new neurons in the adult brain, contrary to established dogma, hope for therapy from devastating neurological diseases was generated. The potential for stem cells to provide functional recovery in humans remains to be further tested and to further move into the clinical trial realm. The future certainly has great promise on stem cells to assist in alleviation of difficult-to-treat neurologic disorders. This article reviews classic studies of the 1990s and 2000s that paved the way for the advances of today, which can in turn lead to tomorrow's therapies.
authors: a Department of Neuroscience , University of Pittsburgh , Pittsburgh , PA , USA.
authors: Vivek
authors: V
authors: Verma
authors: a Department of Neuroscience , University of Pittsburgh , Pittsburgh , PA , USA.
authors: Keerthana
authors: K
authors: Samanthapudi
authors: a Department of Neuroscience , University of Pittsburgh , Pittsburgh , PA , USA.
authors: Ratujit
authors: R
authors: Raviprakash
mesh_terms: D001921:Brain / Q000166:cytology; D002454:Cell Differentiation; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D058953:Neural Stem Cells; D055495:Neurogenesis / Q000502:physiology*; D009488:Neurosciences / Q000266:history*; D012038:Regeneration / Q000502:physiology*
keywords: brain regeneration; developmental neuroscience; neural stem cells; neurogenesis; neurological diseases