title: Reduced risk of pertussis in whole-cell compared to acellular vaccine recipients is not confounded by age or receipt of booster-doses.
abstract: Several observational studies provide evidence that acellular pertussis vaccines (aP) are less protective against pertussis disease than highly effective whole-cell pertussis vaccines (wP), however, concerns have been raised that some of these findings may be confounded by age. By undertaking age-stratified and restricted analyses on a cohort of Australian children primed with either aP-only, wP-only or mixed pertussis vaccine schedules, we demonstrate that compared to aP the association of wP with increased protection from pertussis is not confounded by age, nor by aP booster-dose receipt.
authors: Queensland Children's Medical Research Institute, Children's Health Queensland, Brisbane, Australia; School of Public Health, The University of Queensland, Brisbane, Australia. Electronic address: s.sheridan@uq.edu.au.
authors: Sarah L
authors: SL
authors: Sheridan
authors: Queensland Children's Medical Research Institute, Children's Health Queensland, Brisbane, Australia; School of Public Health, The University of Queensland, Brisbane, Australia; UQ Child Health Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia.
authors: Robert S
authors: RS
authors: Ware
authors: Queensland Children's Medical Research Institute, Children's Health Queensland, Brisbane, Australia; Griffith University and Gold Coast Health, Gold Coast, Australia.
authors: Keith
authors: K
authors: Grimwood
authors: Queensland Children's Medical Research Institute, Children's Health Queensland, Brisbane, Australia; UQ Child Health Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia; Communicable Diseases Branch, Queensland Health, Brisbane, Australia.
authors: Stephen B
authors: SB
authors: Lambert
mesh_terms: D000367:Age Factors; D001315:Australia; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D022282:Vaccines, Acellular / Q000008:administration & dosage / Q000276:immunology; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control*
chemical_list: D010567:Pertussis Vaccine; D022282:Vaccines, Acellular; D015164:Vaccines, Inactivated
keywords: Acellular pertussis vaccine; Confounding; Pertussis; Vaccine effectiveness; Whole-cell pertussis vaccine