title: [GLIATILIN CORRECTION OF WORKING AND REFERENCE SPATIAL MEMORY IMPAIRMENT IN AGED RATS].
abstract: This work was aimed at evaluating the influence of gliatilin administration on the spatial memory in aged rats. Cognitive function and spatial memory in animals was evaluated using radial (8-beam) maze test. Errors of working spatial memory and reference memory were used as indicators of impaired cognitive function. It was found that aged (24-month) rats compared with younger (6-months) age group exhibited cognitive impairment, as manifested by deterioration of short- and long-term memory processes. Course administration of gliatilin in rats of the older age group at a dose of 100 mg/kg resulted in significant improvement of the working and reference spatial memory in aged rats.
authors: I N
authors: IN
authors: Tyurenkov
authors: E V
authors: EV
authors: Volotova
authors: D V
authors: DV
authors: Kurkin
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D005997:Glycerylphosphorylcholine / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000188:drug therapy / Q000503:physiopathology; D051381:Rats
chemical_list: D005997:Glycerylphosphorylcholine