title: [Extraoseus Ewings Sarcoma, Primary Affection of Uterine Cervix--Case Report].
abstract: BACKGROUND
  Ewing's sarcoma is usually diagnosed in adolescents and young adults, peak of incidence is around 15 years of age. Primary localization is mostly in the skeleton of long bones and chest wall. Primary extraosseous involvement rarely occurs, incidence increases with age.
  
  
  METHODS
  We present a case report of a 57-year-old patient with locally advanced tumors of the cervix, clinical stage IIB. Due to histological and molecular genetic examination revealing EWS -ERG fusion gene, Ewing's sarcoma was diagnosed. CT revealed pathological pelvic lymphadenopathy and multiple pulmonary bilateral methastases, scintigraphy did not prove any affection of skeleton. The patient underwent a two-stage intensive chemotherapy regimens VIDE (vincristine, ifosfamide, doxorubicin, etoposide) and VAI (vincristine, actinomycin D, ifosfamide). During the second phase, concomitant radiotherapy of pelvis was aplied. According to PET/CT, complete remission was achieved. Whole-lung irradiation was applied in consolidation of the result.
  
  
  CONCLUSIONS
  Primary Ewing's sarcoma of the cervix is an extremely rare disease. To our knowledge, only 12 cases was presented until this time. The average age at time of dia-gnosis was 35 years. Unlike the previous reports, we initially diagnosed distant metastases. The treatment was led according to the protocol Ewing 2008 designed for primary skeletal Ewing's sarcoma. Currently, 18 months after the therapy, the patient is without signs of disease. However, long-term follow-up is necessary.
authors: O
authors: O
authors: Bílek
authors: M
authors: M
authors: Holánek
authors: M
authors: M
authors: Zvaríková
authors: P
authors: P
authors: Fabian
authors: B
authors: B
authors: Robešová
authors: M
authors: M
authors: Procházková
authors: D
authors: D
authors: Adámková Krákorová
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D012512:Sarcoma, Ewing / Q000473:pathology / Q000628:therapy*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents