title: Evolution of serum and intra-graft donor-specific anti-HLA antibodies in a patient with two consecutive liver transplantations.
abstract: The current literature suggests that anti-HLA donor-specific antibodies (DSA) may have deleterious effects on liver grafts but there is no proof that they are directly involved in the graft lesions. We report the case of a donor HLA-sensitized patient who needed a second graft 6 months after the first transplantation owing to a progressive cholestatic disease that we could finally attribute to antibody-mediated rejection (AMR). We describe the longitudinal evolution of graft function, tissue histology, serum DSA and, for the first time, intra-graft DSA after elution from biopsies.
authors: Liver Transplantation Unit, Department of Hepato-Gastroenterology, Nutrition and Diabetology, Bordeaux University Hospital, France; Department of Anesthesia and Resuscitation, Bordeaux University Hospital, France. Electronic address: martine.neau-cransac@chu-bordeaux.fr.
authors: Martine
authors: M
authors: Neau-Cransac
authors: Pathology Department, Bordeaux University Hospital, Bordeaux, France.
authors: Brigitte
authors: B
authors: Le Bail
authors: Laboratory of Immunology and Immunogenetics, Bordeaux University Hospital, France.
authors: Gwendaline
authors: G
authors: Guidicelli
authors: Laboratory of Immunology and Immunogenetics, Bordeaux University Hospital, France; CNRS UMR 5164, CIRID, University of Bordeaux, France.
authors: Jonathan
authors: J
authors: Visentin
authors: Department of Nephrology, Dialysis and Transplantation, Bordeaux University Hospital, France.
authors: Karine
authors: K
authors: Moreau
authors: Department of Nephrology, Dialysis and Transplantation, Bordeaux University Hospital, France.
authors: Alice
authors: A
authors: Quinart
authors: Department of Nephrology, Dialysis and Transplantation, Bordeaux University Hospital, France.
authors: Anna
authors: A
authors: Boueilh
authors: Department of Digestive Surgery, Bordeaux University Hospital, France.
authors: Christophe
authors: C
authors: Laurent
authors: Laboratory of Immunology and Immunogenetics, Bordeaux University Hospital, France; CNRS UMR 5164, CIRID, University of Bordeaux, France. Electronic address: jean-luc.taupin@chu-bordeaux.fr.
authors: Jean-Luc
authors: JL
authors: Taupin
mesh_terms: D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D056724:Immunity, Humoral; D007518:Isoantibodies / Q000378:metabolism*; D008099:Liver / Q000276:immunology / Q000378:metabolism*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012086:Reoperation
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies
keywords: Antibody elution; Antibody-mediated rejection; Liver biopsy