title: Seizing control of epileptic activity can improve outcome.
abstract: In epileptic encephalopathy, the seizures and interictal epileptiform activity create additional neurocognitive dysfunction beyond that due to the underlying etiology. Treatment leading to a reduction in seizures or interictal abnormalities may help improve neurocognitive function in these situations. The focus of our discussion is reviewing data that support the concept that treatment can impact outcome independent of the etiology in some cases.
authors: Departments of Pediatrics and Neurology, Children's Hospital Colorado, University of Colorado at Denver, Aurora, Colorado, U.S.A.
authors: Kevin E
authors: KE
authors: Chapman
authors: Department of Neuroscience, Bambino Gesù Children's Hospital, Rome, Italy.
authors: Nicola
authors: N
authors: Specchio
authors: Neurology and Pediatrics, Montefiore Medical Center, New York, New York, U.S.A.
authors: Shlomo
authors: S
authors: Shinnar
authors: Neurology, University of Vermont, Burlington, Vermont, U.S.A.
authors: Gregory L
authors: GL
authors: Holmes
mesh_terms: D003072:Cognition Disorders / Q000209:etiology*; D004827:Epilepsy / Q000150:complications* / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics; D062550:NAV1.1 Voltage-Gated Sodium Channel / Q000235:genetics; D012640:Seizures / Q000209:etiology* / Q000235:genetics / Q000628:therapy*
chemical_list: D062550:NAV1.1 Voltage-Gated Sodium Channel; C568242:SCN1A protein, human
keywords: Cognitive impairment; Epilepsy; Epileptic encephalopathy; Humans; Treatment