title: Bioavailability and biodistribution of nanodelivered lutein.
abstract: The aim of the study was to evaluate the ability of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) to enhance lutein bioavailability. The bioavailability of free lutein and PLGA-NP lutein in rats was assessed by determining plasma pharmacokinetics and deposition in selected tissues. Lutein uptake and secretion was also assessed in Caco-2 cells. Compared to free lutein, PLGA-NP increased the maximal plasma concentration (Cmax) and area under the time-concentration curve in rats by 54.5- and 77.6-fold, respectively, while promoting tissue accumulation in the mesenteric fat and spleen. In comparison with micellized lutein, PLGA-NP lutein improved the Cmax in rat plasma by 15.6-fold and in selected tissues by ⩾ 3.8-fold. In contrast, PLGA-NP lutein had a lower uptake and secretion of lutein in Caco-2 cells by 10.0- and 50.5-fold, respectively, compared to micellized lutein. In conclusion, delivery of lutein with polymeric NP may be an approach to improve the bioavailability of lutein in vivo.
authors: Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St., Boston, MA 02111, United States.
authors: Alison
authors: A
authors: Kamil
authors: Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St., Boston, MA 02111, United States.
authors: Donald E
authors: DE
authors: Smith
authors: Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St., Boston, MA 02111, United States.
authors: Jeffrey B
authors: JB
authors: Blumberg
authors: Department of Biological & Agricultural Engineering, Louisiana State University, 149 E. B. Doran Building, Baton Rouge, LA 70803, United States.
authors: Carlos
authors: C
authors: Astete
authors: Department of Biological & Agricultural Engineering, Louisiana State University, 149 E. B. Doran Building, Baton Rouge, LA 70803, United States.
authors: Cristina
authors: C
authors: Sabliov
authors: Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St., Boston, MA 02111, United States. Electronic address: Oliver.Chen@tufts.edu.
authors: C-Y
authors: CY
authors: Oliver Chen
mesh_terms: D000818:Animals; D001682:Biological Availability; D018938:Caco-2 Cells / Q000737:chemistry*; D006801:Humans; D014975:Lutein / Q000737:chemistry*; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D051381:Rats; D014018:Tissue Distribution / Q000502:physiology*
chemical_list: D014975:Lutein
keywords: Bioavailability; Caco-2 cells; Lutein (PubChem CID: 5281243); Nanoparticles; Poly(lactic-co-glycolic acid) (PubChem CID: 23111554); Rats