title: [STUDYING NEUROPROTECTIVE ACTIVITY OF GABA CONJUGATE WITH ARACHIDONIC ACID UNDER CONDITIONS OF LOCAL PERMANENT BRAIN ISCHEMIA IN RATS].
abstract: We have studied the effect of a GABA conjugate with arachidonic acid (AA) on the morphological state of rat brain tissues after left median cerebral artery occlusion. The results showed that a 6- and 12-day course administration of the GABA - AA conjugate at dose of 2 mg/kg (i.p.) in rats with this model of local permanent brain ischemia led to significant recovery processes in brain tissues. The tissue morphology pattern in the group of animals treated with the GABSA - AA conjugate for 12 days was almost identical to that in intact tissues.
authors: N R
authors: NR
authors: Mirzoyan
authors: N G
authors: NG
authors: Hostikyan
authors: A G
authors: AG
authors: Stepanyan
authors: A A
authors: AA
authors: Akopyan
authors: K B
authors: KB
authors: Alikhanyan
authors: V S
authors: VS
authors: Meliksetyan
authors: N A
authors: NA
authors: Bagdasaryan
authors: N M
authors: NM
authors: Gretskaya
authors: V V
authors: VV
authors: Bezuglov
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D018682:GABA Agents / Q000494:pharmacology; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D001095:Arachidonic Acids; D018682:GABA Agents; D018696:Neuroprotective Agents; D005680:gamma-Aminobutyric Acid