title: Assessment of osteoinduction using a porous hydroxyapatite coating prepared by micro-arc oxidation on a new titanium alloy.
abstract: Surface modification and material improvement is now an important way to improve the osseointegration between bone and uncemented prothesis. The purpose of this study was to investigate the bone ingrowth potential of porous hydroxyapatite (HA) coatings prepared by micro-arc oxidation (MAO) on Ti-3Zr-2Sn-3Mo-25Nb, a new titanium alloy. HA-coated specimens were implanted in the left proximal femoral medullary canal of beagles for 4, 12, and 24 weeks, and uncoated specimens were implanted in the right as a control. The surface morphology and phase composition were investigated with environmental scanning electron microscopy and X-ray diffractometry. The bone ingrowth was assessed by histomorphometry. A pull-out test was performed to assess the mechanical performance of the bone-implant interface. A porous coating was well prepared on the new titanium alloy by using the MAO method. The bone-to-implant contact was significantly higher for the HA-coated group compared to that in the uncoated group. Mechanical tests showed that the HA-coated group had significantly higher maximum force at the bone-implant interface compared to the uncoated specimens. MAO is a suitable coating approach for this new titanium alloy. The HA coating prepared by this approach can significantly promote bone ingrowth and the mechanical performance of the bone-implant interface.
authors: Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, Shanxi, China.
authors: Wensen
authors: W
authors: Jing
authors: Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, Shanxi, China.
authors: Minghua
authors: M
authors: Zhang
authors: Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, Shanxi, China.
authors: Lei
authors: L
authors: Jin
authors: Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, Shanxi, China.
authors: Jian
authors: J
authors: Zhao
authors: Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, Shanxi, China.
authors: Qing
authors: Q
authors: Gao
authors: Research Institute for Strength of Metals, Xi'an Jiaotong University, Xi'an 710049, Shanxi, China.
authors: Min
authors: M
authors: Ren
authors: Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, Shanxi, China. Electronic address: 23773052@qq.com.
authors: Qingyu
authors: Q
authors: Fan
mesh_terms: D000497:Alloys; D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004195:Disease Models, Animal; D004285:Dogs; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D008297:Male; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000187:drug effects*; D016062:Porosity; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D014025:Titanium
keywords: Coating; Hydroxyapatite; Micro-arc oxidation; Titanium alloy