title: Oxidative Stress and IgG Antibody Modify Periodontitis-CRP Association.
abstract: In a previous report, we demonstrated the inverse association of high serum 8-isoprostane levels, a marker for oxidative stress, with decreased serum IgG antibodies to oral bacteria. The association between increased serum IgG with increased plaque and periodontitis (increased probing depths) was attenuated by high systemic oxidative stress. Other investigations have reported a role for systemic oxidative stress as a stimulus of hepatic C-reactive protein (CRP) response. These observations led us to hypothesize that the reported relationship of periodontitis to elevated serum CRP, a systemic inflammatory marker, may be modified by oxidative stress and that the levels of serum antibodies to oral bacteria might be an intermediary explanatory variable linking the association of systemic oxidative stress, periodontal disease, and levels of CRP. This hypothesis was explored as a secondary analysis of the Dental ARIC (Atherosclerosis Risk in Communities) study using serum levels of CRP, serum IgG levels to 16 oral organisms, serum levels of 8-isoprostane, and periodontal status. The findings indicate periodontitis is associated with high CRP in the presence of elevated oxidative stress that serves to suppress the IgG response. Only within the highest 8-isoprostane quartile was periodontitis (pocket depth) associated with increased serum CRP levels (P = 0.0003). Increased serum IgG antibody levels to oral bacteria were associated with lowered serum CRP levels. Thus, systemic oxidative stress, which has been demonstrated to be associated with increased levels of CRP in other studies, appears to be associated with the suppression of bacterial-specific IgG levels, which in the presence of periodontal disease can result in an enhanced systemic CRP response. Conversely, individuals with increased serum IgG antibodies to plaque bacteria exhibit lowered serum CRP levels. These 2 factors, oxidative stress and the serum IgG response, appear to function in opposing directions to modify serum levels of CRP and the association with periodontitis.
authors: Center for Oral and Systemic Diseases and Department of Periodontology, University of North Carolina at Chapel Hill, School of Dentistry, Chapel Hill, NC, USA.
authors: R E
authors: RE
authors: Singer
authors: Center for Oral and Systemic Diseases and Department of Dental Ecology, University of North Carolina at Chapel Hill, School of Dentistry, Chapel Hill, NC, USA.
authors: K
authors: K
authors: Moss
authors: Center for Oral and Systemic Diseases and Department of Periodontology, University of North Carolina at Chapel Hill, School of Dentistry, Chapel Hill, NC, USA.
authors: S J
authors: SJ
authors: Kim
authors: Center for Oral and Systemic Diseases and Department of Dental Ecology, University of North Carolina at Chapel Hill, School of Dentistry, Chapel Hill, NC, USA.
authors: J D
authors: JD
authors: Beck
authors: Center for Oral and Systemic Diseases and Department of Periodontology, University of North Carolina at Chapel Hill, School of Dentistry, Chapel Hill, NC, USA Steve_Offenbacher@dentistry.unc.edu.
authors: S
authors: S
authors: Offenbacher
mesh_terms: D018441:Biofilms; D002097:C-Reactive Protein / Q000032:analysis / Q000502:physiology*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood / Q000502:physiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology; D018384:Oxidative Stress / Q000502:physiology*; D010518:Periodontitis / Q000097:blood / Q000276:immunology / Q000503:physiopathology*; D011446:Prospective Studies
chemical_list: D007074:Immunoglobulin G; C075750:8-epi-prostaglandin F2alpha; D002097:C-Reactive Protein; D015237:Dinoprost
keywords: acute phase reaction; bacteria; biomarkers; biostatistics; host pathogen interaction; immunity