title: Characterization of the Sublimation and Vapor Pressure of 2-(2-Nitrovinyl) Furan (G-0) Using Thermogravimetric Analysis: Effects of Complexation with Cyclodextrins.
abstract: In the present work, the sublimation of crystalline solid 2-(2-nitrovinyl) furan (G-0) in the temperature range of 35 to 60 °C (below the melting point of the drug) was studied using thermogravimetric analysis (TGA). The sublimated product was characterized using Fourier-transformed-infrared spectroscopy (FT-IR) and thin layer chromatography (TLC). The sublimation rate at each temperature was obtained using the slope of the linear regression model and followed apparent zero-order kinetics. The sublimation enthalpy from 35 to 60 °C was obtained from the Eyring equation. The Gückel method was used to estimate the sublimation rate and vapor pressure at 25 °C. Physical mixtures, kneaded and freeze-dried complexes were prepared with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD) and analyzed using isothermal TGA at 50 °C. The complexation contributed to reducing the sublimation process. The best results were achieved using freeze-dried complexes with both cyclodextrins.
authors: Departamento de Farmacia, Facultad de Química y Farmacia, Carretera a Camajuaní km 5½, Universidad Central de Las Villas, 54830 Villa Clara, Cuba. vivianr@uclv.edu.cu.
authors: Vivian
authors: V
authors: Ruz
authors: Departamento de Farmacia, Facultad de Química y Farmacia, Carretera a Camajuaní km 5½, Universidad Central de Las Villas, 54830 Villa Clara, Cuba. mmayra@uclv.edu.cu.
authors: Mirtha Mayra
authors: MM
authors: González
authors: Department of Metallurgy and Material Engineering, Kasteelpark Arenberg 44, University of Leuven (KU Leuven), BE-3001 Heverlee, Belgium. danny.winant@mtm.kuleuven.be.
authors: Danny
authors: D
authors: Winant
authors: Centro de Bioactivos Químicos, Carretera a Camajuaní km 5½, Universidad Central de Las Villas, 54830 Villa Clara, Cuba. guez@uclv.edu.cu.
authors: Zenaida
authors: Z
authors: Rodríguez
authors: Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, O & N2 Herestraat 49-Box 921, University of Leuven (KU Leuven), BE-3000 Leuven, Belgium. guy.vandenmooter@pharm.kuleuven.be.
authors: Guy
authors: G
authors: Van den Mooter
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins / Q000737:chemistry*; D005612:Freeze Drying; D005663:Furans / Q000737:chemistry*; D012044:Regression Analysis; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D013997:Time Factors; D055548:Vapor Pressure; D014753:Vinyl Compounds / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D005663:Furans; D014753:Vinyl Compounds; D047392:beta-Cyclodextrins; C517823:trans-2-(2-nitrovinyl)furan; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C093196:SBE4-beta-cyclodextrin
keywords: 2-(2-nitrovinyl) furan; cyclodextrins; sublimation enthalpy; thermogravimetry; vapor pressure