title: Regulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
abstract: Cell signaling pathways are the mechanisms by which cells transduce external stimuli, which control the transcription of genes, to regulate diverse biological effects. In cancer, distinct signaling pathways, such as the Wnt/β-catenin pathway, have been implicated in the deregulation of critical molecular processes that affect cell proliferation and differentiation. For example, changes in β-catenin localization have been identified in Human Papillomavirus (HPV)-related cancers as the lesion progresses. Specifically, β-catenin relocates from the membrane/cytoplasm to the nucleus, suggesting that this transcription regulator participates in cervical carcinogenesis. The E6 and E7 oncoproteins are responsible for the transforming activity of HPV, and some studies have implicated these viral oncoproteins in the regulation of the Wnt/β-catenin pathway. Nevertheless, new interactions of HPV oncoproteins with cellular proteins are emerging, and the study of the biological effects of such interactions will help to understand HPV-related carcinogenesis. Viruses 2015, 7 4735 This review addresses the accumulated evidence of the involvement of the HPV E6 and E7 oncoproteins in the activation of the Wnt/β-catenin pathway.
authors: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Av. Universidad 3000, Col. Ciudad Universitaria, Del. Coyoacán, México DF CP. 04510, Mexico. omarmube@gmail.com.
authors: Jesus Omar Muñoz
authors: JO
authors: Bello
authors: Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000,Col. Ciudad Universitaria, Del. Coyoacán, México DF CP. 04510, Mexico. leslie_azul25@hotmail.com.
authors: Leslie Olmedo
authors: LO
authors: Nieva
authors: Unidad de Investigación Biomédica en Cáncer/Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Av. San Fernando 22, Col. Sección XVI, Del. Tlalpan, México DF CP. 14080, Mexico. adrycont@yahoo.com.mx.
authors: Adriana Contreras
authors: AC
authors: Paredes
authors: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Av. Universidad 3000, Col. Ciudad Universitaria, Del. Coyoacán, México DF CP. 04510, Mexico. alma_mariana2000@yahoo.com.mx.
authors: Alma Mariana Fuentes
authors: AM
authors: Gonzalez
authors: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Av. Universidad 3000, Col. Ciudad Universitaria, Del. Coyoacán, México DF CP. 04510, Mexico. lrochaz@biomedicas.unam.mx.
authors: Leticia Rocha
authors: LR
authors: Zavaleta
authors: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Av. Universidad 3000, Col. Ciudad Universitaria, Del. Coyoacán, México DF CP. 04510, Mexico. lizanosoberon@gmail.com.|Unidad de Investigación Biomédica en Cáncer/Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Av. San Fernando 22, Col. Sección XVI, Del. Tlalpan, México DF CP. 14080, Mexico. lizanosoberon@gmail.com.
authors: Marcela
authors: M
authors: Lizano
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D054884:Host-Pathogen Interactions; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D027383:Papillomaviridae / Q000502:physiology*; D060449:Wnt Signaling Pathway
chemical_list: D009856:Oncogene Proteins, Viral
keywords: HPV E6 and E7 oncoproteins; HPV-related cancers; Wnt/β-catenin