title: Is cognitive stability in Parkinson's disease a predictable phenomenon? A 5-year follow-up study.
abstract: Cognitive disturbances are integral to the course of PD but the rate of cognitive decline remains largely unpredictable. The aim of this study was to determine the clinical features associated with "cognitive stability". Fifty-four patients (32 with normal cognition and 22 featuring MCI) were recruited in 2009 and re-evaluated after a mean time of 4.7 years; all patients underwent a detailed neuropsychological and clinical evaluation. A proportion of 61 % of patients (19 with normal cognition and 14 with MCI) remained cognitive stable, whereas 39 % had reduced cognitive reserve. After multivariate analysis, only the preservation of visuo-spatial domain was predictive of cognitive stability.
authors: Department of Neurology and Psychiatry, University of Rome "Sapienza", C.I.M.S. Centro Interdipartimentale Malattie Sociali, Rome, Italy.
authors: Maria Elena
authors: ME
authors: Di Battista
authors: Department of Neurology and Psychiatry, University of Rome "Sapienza", C.I.M.S. Centro Interdipartimentale Malattie Sociali, Rome, Italy.
authors: Alfonso
authors: A
authors: Rubino
authors: Department of Neurology and Psychiatry, University of Rome "Sapienza", C.I.M.S. Centro Interdipartimentale Malattie Sociali, Rome, Italy.
authors: Marcella
authors: M
authors: Valente
authors: Department of Neurology and Psychiatry, University of Rome "Sapienza", C.I.M.S. Centro Interdipartimentale Malattie Sociali, Rome, Italy.
authors: Patrizia
authors: P
authors: Giustini
authors: Department of Neurology and Psychiatry, University of Rome "Sapienza", C.I.M.S. Centro Interdipartimentale Malattie Sociali, Rome, Italy.
authors: Nicola
authors: N
authors: Vanacore
authors: Department of Neurology and Psychiatry, University of Rome "Sapienza", C.I.M.S. Centro Interdipartimentale Malattie Sociali, Rome, Italy. giuseppe.meco@uniroma1.it.
authors: Giuseppe
authors: G
authors: Meco
mesh_terms: D000368:Aged; D003071:Cognition; D060825:Cognitive Dysfunction / Q000150:complications*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis / Q000523:psychology*; D011379:Prognosis
keywords: Cognitive conversion; Cognitive stability; Dementia; Mild cognitive impairment; Parkinson; Visuo-spatial functions