title: BaHoF5 nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke.
abstract: CT angiography (CTA) and CT perfusion (CTP) imaging can play important roles in the workup of acute ischemic stroke. However, these techniques are hindered by the large amounts of contrast agents (CAs) required, high doses of X-ray radiation exposure, and nephrotoxicity of the clinical used iodinated CAs. To address these problems, we synthesized and validated a novel class of CT CAs, PEGylated BaHoF5 nanoparticles (NPs), for CTA and CTP imaging, which can greatly enhance the diagnostic sensitivity and accuracy of ischemic stroke. These agents have unique advantages over conventional iodinated CT agents, including much lower dosage required, major metabolism through liver and better imaging efficiency at different voltages. Once translated, these PEGylated BaHoF5 NPs can replace iodine-based CAs for diagnostic contrast-enhanced imaging of patients with kidney/heart diseases and improve the overall diagnostic index with negligible side effects.
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Jing
authors: J
authors: Wang
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
authors: Dalong
authors: D
authors: Ni
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China; State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China. Electronic address: wbbu@mail.sic.ac.cn.
authors: Wenbo
authors: W
authors: Bu
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Qian
authors: Q
authors: Zhou
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
authors: Wenpei
authors: W
authors: Fan
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Yue
authors: Y
authors: Wu
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
authors: Yanyan
authors: Y
authors: Liu
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Lekang
authors: L
authors: Yin
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
authors: Zhaowen
authors: Z
authors: Cui
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Xiaoxue
authors: X
authors: Zhang
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Hua
authors: H
authors: Zhang
authors: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address: zwyao@fudan.edu.cn.
authors: Zhenwei
authors: Z
authors: Yao
mesh_terms: D000818:Animals; D017609:Barium Compounds / Q000737:chemistry*; D002545:Brain Ischemia / Q000000981:diagnostic imaging*; D002460:Cell Line; D003287:Contrast Media; D008297:Male; D051379:Mice; D053758:Nanoparticles; D051381:Rats; D017207:Rats, Sprague-Dawley; D020521:Stroke / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
chemical_list: D017609:Barium Compounds; D003287:Contrast Media
keywords: BaHoF(5) nanoparticles; CT angiography imaging; CT perfusion imaging; Ischemic stroke; Multi-modal CT imaging