title: Copper-catalyzed oxidative decarboxylative C-H arylation of benzoxazoles with 2-nitrobenzoic acids.
abstract: A copper-catalyzed oxidative decarboxylative coupling of benzoxazoles with 2-nitrobenzoic acids was developed. This methodology favors electron-rich benzoxazoles and electron-deficient benzoic acids and enables the preparation of a variety of arylated benzoxazoles in good yields. The trends in product yields suggest a delicate balance between the decarboxylation and C-H arylation steps.
authors: C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, USA. Jessica.Hoover@mail.wvu.edu.
authors: Lijun
authors: L
authors: Chen
authors: Lin
authors: L
authors: Ju
authors: Katelyn A
authors: KA
authors: Bustin
authors: Jessica M
authors: JM
authors: Hoover
mesh_terms: D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D015394:Molecular Structure; D009579:Nitrobenzoates / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: C518437:2-nitrobenzoate; D001583:Benzoxazoles; D009579:Nitrobenzoates; D003300:Copper