title: Effects of Fronto-Temporal Transcranial Direct Current Stimulation on Auditory Verbal Hallucinations and Resting-State Functional Connectivity of the Left Temporo-Parietal Junction in Patients With Schizophrenia.
abstract: Auditory verbal hallucinations (AVH) in patients with schizophrenia are associated with abnormal hyperactivity in the left temporo-parietal junction (TPJ) and abnormal connectivity between frontal and temporal areas. Recent findings suggest that fronto-temporal transcranial Direct Current stimulation (tDCS) with the cathode placed over the left TPJ and the anode over the left prefrontal cortex can alleviate treatment-resistant AVH in patients with schizophrenia. However, brain correlates of the AVH reduction are unclear. Here, we investigated the effect of tDCS on the resting-state functional connectivity (rs-FC) of the left TPJ. Twenty-three patients with schizophrenia and treatment-resistant AVH were randomly allocated to receive 10 sessions of active (2 mA, 20 min) or sham tDCS (2 sessions/d for 5 d). We compared the rs-FC of the left TPJ between patients before and after they received active or sham tDCS. Relative to sham tDCS, active tDCS significantly reduced AVH as well as the negative symptoms. Active tDCS also reduced rs-FC of the left TPJ with the left anterior insula and the right inferior frontal gyrus and increased rs-FC of the left TPJ with the left angular gyrus, the left dorsolateral prefrontal cortex and the precuneus. The reduction of AVH severity was correlated with the reduction of the rs-FC between the left TPJ and the left anterior insula. These findings suggest that the reduction of AVH induced by tDCS is associated with a modulation of the rs-FC within an AVH-related brain network, including brain areas involved in inner speech production and monitoring.
authors: EA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France;
authors: Marine
authors: M
authors: Mondino
authors: Laboratoire de Sciences Cognitives & Affectives (SCA-Lab), UMR CNRS 9193, Université de Lille & CURE, Hôpital Fontan, CHRU de Lille, F-59000, Lille, France.
authors: Renaud
authors: R
authors: Jardri
authors: EA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France;
authors: Marie-Françoise
authors: MF
authors: Suaud-Chagny
authors: EA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France;
authors: Mohamed
authors: M
authors: Saoud
authors: EA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France;
authors: Emmanuel
authors: E
authors: Poulet
authors: EA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France; jerome.brunelin@ch-le-vinatier.fr.
authors: Jérôme
authors: J
authors: Brunelin
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods*; D006212:Hallucinations / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D010296:Parietal Lobe / Q000503:physiopathology*; D012559:Schizophrenia / Q000150:complications / Q000628:therapy*; D013067:Speech Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000503:physiopathology*; D065908:Transcranial Direct Current Stimulation / Q000379:methods*; D016896:Treatment Outcome
keywords: brain stimulation; fMRI; resting state; temporal cortex