title: Association of hOGG1 Ser326Cys polymorphism with susceptibility to hepatocellular carcinoma.
abstract: BACKGROUND
  Since, the relationship between hOGG1 Ser326Cys polymorphism and HCC was inconsistent in the recent literatures. The present meta-analysis based on previous studies was to obtain precise estimation on the issue.
  
  
  METHODS
  A computer search was carried out from PubMed, CBM and EMBASE databases. A total of nine case-control publications with 2583 HCC patients and 2271 controls were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the relationship of Ser326Cys polymorphism and HCC susceptibility. Z test was used to assess the significance of pooled OR. The fixed-effect model or random-effect model was employed according to heterogeneity.
  
  
  RESULTS
  Overall, hOGG1 Ser326Cys polymorphism was in relation with increased risk for HCC under the following genetic models: GG versus CC: OR=2.51, 95% CI=1.67-3.78; GG versus CG + CC: OR=2.27, 95% CI=1.57-3.30; GG + CG versus CC: OR=1.13, 95% CI=1.03-1.24. The subgroup analysis by ethnicity suggested that high risk for HCC was observed in Asians with GG and GG + CG genotype (GG versus CC: OR=2.17, 95% CI=1.49-3.17; GG versus CG + CC: OR=1.96, 95% CI=1.41-2.73; GG + CG versus CC: OR=1.13, 95% CI=1.03-1.25). For subgroup analysis based on source of control, GG genotype of Ser326Cys was significantly associated with HCC risk in hospital-based (HB) controls (GG versus CC: OR=2.31, 95% CI=1.50-3.56; GG versus CG + CC: OR=2.17, 95% CI=1.44-3.28), as well as in population-based (PB) models (GG vs. CC: OR=2.80, 95% CI=1.16-6.77; GG versus CG + CC: OR=2.39, 95% CI=1.08-5.30).
  
  
  CONCLUSIONS
  According to the results, hOGG1 Ser326Cys polymorphism was associated with increased risk of HCC.
authors: Department of Clinical Laboratory, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, China.
authors: Jun
authors: J
authors: Guo
authors: Department of Microbiology, School of Basic Medical Sciences, Hubei University of Medicine Shiyan 442000, Hubei, China.
authors: Jing
authors: J
authors: Yang
authors: Department of Clinical Laboratory, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, China.
authors: Yan
authors: Y
authors: Li
keywords: Human 8-oxoguanine glycosylase 1; Ser326Cys; hepatocellular carcinoma; risk