title: Effects of primaquine and chloroquine on oxidative stress parameters in rats.
abstract: Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in the kidney after 7 days, and decreases TBARS levels in the brain after 21 days. Moreover, decreases protein carbonyls in the liver after 7 and 14 days, and in the brain after 7 and 21 days. However, chloroquine treatment for 14 days increases protein carbonyls in the brain and kidney. In conclusion, these results showed that prolonged treatment with antimalarial may adversely affect the DNA.
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Francianne
authors: F
authors: Giovanella
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Gabriela K
authors: GK
authors: Ferreira
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Samira D T
authors: SD
authors: de Prá
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Milena
authors: M
authors: Carvalho-Silva
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Lara M
authors: LM
authors: Gomes
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Giselli
authors: G
authors: Scaini
authors: Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Porto Alegre, RS, BR.
authors: Renata C
authors: RC
authors: Gonçalves
authors: Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Porto Alegre, RS, BR.
authors: Monique
authors: M
authors: Michels
authors: Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Porto Alegre, RS, BR.
authors: Letícia S
authors: LS
authors: Galant
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Luiza M
authors: LM
authors: Longaretti
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Ana Luiza
authors: AL
authors: Dajori
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Vanessa M
authors: VM
authors: Andrade
authors: Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Porto Alegre, RS, BR.
authors: Felipe
authors: F
authors: Dal-Pizzol
authors: Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
authors: Emilio L
authors: EL
authors: Streck
authors: Instituto de Ciências Biológicas, UFMG, Belo Horizonte, MG, BR.
authors: Renan P
authors: RP
authors: de Souza
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D002738:Chloroquine / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011319:Primaquine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine