title: Potential Roles of Selenium and Selenoproteins in the Prevention of Alzheimer's Disease.
abstract: Alzheimer's disease is a devastating and invariably fatal neurodegenerative brain disorder with no cure. AD is characterized by two pathological protein deposits, the senile plaques composed mainly of amyloid-β (Aβ) peptide and the neurofibrillary tangles which are bundles of paired helical filaments (PHF) of protein tau. In addition, oxidative stress, disorders in signal transduction and metal ions dyshomeostasis also play significant roles in the development of AD. A large body of studies suggests that selenium (Se), either as Se-containing compounds or as selenoproteins, may be beneficial in reducing Alzheimer's pathology. Se is involved in most of the molecular pathways that are important in the progression of AD. We reviewed the literature regarding Se and AD and discussed the roles and mechanisms of Se in AD, as well as the potential of Se in AD prevention.
authors: Xiubo
authors: X
authors: Du
authors: Chao
authors: C
authors: Wang
authors: College of Life Sciences, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen 518060, China. liuqiong@szu.edu.cn.
authors: Qiong
authors: Q
authors: Liu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D012643:Selenium / Q000494:pharmacology / Q000502:physiology*; D018036:Selenium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D051140:Selenoproteins / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology; D016875:tau Proteins / Q000378:metabolism
chemical_list: C054369:MAPT protein, human; D018036:Selenium Compounds; D051140:Selenoproteins; D054852:Small Molecule Libraries; D016875:tau Proteins; D012643:Selenium