title: [Expression and Clinical Significance of Bmi-1 and P14 in Extranodal NK/T-cell Lymphoma].
abstract: OBJECTIVE
  This study was aimed to investigate the expression and clinical significance of Bmi-1 and P14 in extranodal NK/T-cell lymphoma (ENKTCL) tissue.
  
  
  METHODS
  Maxvision immunohistochemistry technique was used to detect the expression level of Bmi-1 and P14 in the tissues of 21 patients with ENKTCL and 11 normal lymph nodes. The correlation of Bmi-1 or P14 expression with the clinical features and the correlation between Bmi-1 and P14 expression were analyzed.
  
  
  RESULTS
  The expression of Bmi-1 protein was higher in tissues of ENKTCL than that in tissues of lymph nodes, and the Bmi-1 expression levels did not correlate with patients' sex, age, lactate dehydrogenase (LDH), International Prognostic Index (IPI) scores and B symptoms (P > 0.05), except for clinical stage (P < 0.05). The P14 protein expression level was lower in ENKTCL tissues than in normal lymph node tissues, which did not correlate with age, sex, LDH, IPI scores, clinical stage and B symptoms. Correlation test showed a negative correlation between Bmi-1 and P14 (r = -0.472, P = 0.031).
  
  
  CONCLUSIONS
  Bmi-1 protein over-expresses in ENKTCL tissues that may display a negative-regulation effect on P14 in the genesis and progress of ENKTCL.
authors: Fujian Insitute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China.
authors: Lang-Hui
authors: LH
authors: Zhang
authors: Fujian Insitute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China.
authors: Shun-Quan
authors: SQ
authors: Wu
authors: Fujian Insitute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China.
authors: Hao-Bo
authors: HB
authors: Huang
authors: Fujian Insitute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China.
authors: Wen-Yan
authors: WY
authors: Niu
authors: Fujian Insitute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China.
authors: Ya-Ping
authors: YP
authors: Li
authors: Fujian Insitute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China . E-mail: deanzhanrong@qq.com.cn.
authors: Rong
authors: R
authors: Zhan
mesh_terms: D016147:Genes, Tumor Suppressor; D006801:Humans; D008198:Lymph Nodes; D054391:Lymphoma, Extranodal NK-T-Cell; D015513:Oncogene Proteins; D063150:Polycomb Repressive Complex 1
chemical_list: C069077:BMI1 protein, human; C401561:CDK2AP2 protein, human; D015513:Oncogene Proteins; D063150:Polycomb Repressive Complex 1