title: [Pulmonary cytotoxicity induced by bleomycin and methotrexate].
abstract: Early detection of drug-induced pulmonary parenchymal injuries is often hampered by nonspecific clinical and X-ray manifestations. The diagnosis is usually based on a history of drug use, clinical and X-ray presentation, and exclusion of other causes of lung tissue injury. Chemical preparations most commonly cause pathological pulmonary changes. Overall, about 10% of all patients receiving chemotherapy develop pathological changes in the lung parenchyma. The main chemical preparations causing lung injury are bleomycin, methotrexate, carmustine, busulfan, and cyclophosphamide. Out of all examination techniques, computed tomography is most sensitive in determining the presence, specific features, and trends in the development of drug-induced pulmonary parenchymal disease. The paper gives the data available in the literature and 2 clinical observations of pulmonary parenchymal disease induced by bleomycin and methotrexate.
authors: Zh V
authors: ZhV
authors: Sheĭkh
authors: A O
authors: AO
authors: Krutskevich
authors: N S
authors: NS
authors: Drebushevskiĭ
authors: S N
authors: SN
authors: Shvaĭko
authors: A P
authors: AP
authors: Dunaev
authors: V G
authors: VG
authors: Alekseev
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D001761:Bleomycin / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects*; D008171:Lung Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging*; D008727:Methotrexate / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D000903:Antibiotics, Antineoplastic; D007166:Immunosuppressive Agents; D001761:Bleomycin; D008727:Methotrexate