title: A Hollow Foldecture with Truncated Trigonal Bipyramid Shape from the Self-Assembly of an 11-Helical Foldamer.
abstract: The creation of self-assembling microscale architectures that possess new and useful physical properties remains a significant challenge. Herein we report that an 11-helical foldamer self-assembles in a controlled manner to form a series of 3D foldectures with unusual three-fold symmetrical shapes that are distinct from those generated from 12-helical foldamers. The foldamer packing motif was revealed by powder X-ray diffraction technique, and provides an important link between the molecular-level symmetry and the microscale morphologies. The utility of foldectures with hollow interiors as robust and well-defined supramolecular hosts was demonstrated for inorganic, organic, and even protein guests. This work will pave the way for the design of functional foldectures with greater 3D shape diversity and for the development of biocompatible delivery vehicles and containment vessels.
authors: Department of Chemistry, KAIST, Molecular-Level Interface Research Center, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea) http://hslee.kaist.ac.kr.
authors: Jae-Hoon
authors: JH
authors: Eom
authors: Department of Chemistry, KAIST, Molecular-Level Interface Research Center, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea) http://hslee.kaist.ac.kr.
authors: Jintaek
authors: J
authors: Gong
authors: Department of Chemistry, KAIST, Molecular-Level Interface Research Center, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea) http://hslee.kaist.ac.kr.
authors: Sunbum
authors: S
authors: Kwon
authors: Department of Chemistry, KAIST, Molecular-Level Interface Research Center, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea) http://hslee.kaist.ac.kr.
authors: Aram
authors: A
authors: Jeon
authors: Department of Chemistry, KAIST, Molecular-Level Interface Research Center, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea) http://hslee.kaist.ac.kr.
authors: Rokam
authors: R
authors: Jeong
authors: Department of Chemistry, KAIST, Molecular-Level Interface Research Center, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea) http://hslee.kaist.ac.kr.
authors: Russell W
authors: RW
authors: Driver
authors: Department of Chemistry, KAIST, Molecular-Level Interface Research Center, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea) http://hslee.kaist.ac.kr. hee-seung_lee@kaist.ac.kr.
authors: Hee-Seung
authors: HS
authors: Lee
mesh_terms: D008958:Models, Molecular; D008968:Molecular Conformation; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D033362:Powder Diffraction; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D010455:Peptides; D011506:Proteins
keywords: foldamers; hollow nanostructures; host-guest systems; molecular architecture; self-assembly