title: HIV-1 gp120: A Target for Therapeutics and Vaccine Design.
abstract: Although extraordinary progress has been made in the treatment and prevention of HIV infection, the AIDS pandemic continues to rage globally with 2.1 million infections and 1.6 million AIDS-related deaths reported in 2013. Until an effective vaccine is developed, new strategies for treatment and prevention are needed. Regarding the prevention of HIV infection, a major focus of prevention research in general and vaccine research in particular involves the interaction of the HIV-1 envelope protein gp120 with cell-surface receptors, with the hope that a greater understanding of these interactions will lead to the development of novel strategies aimed at preventing and even treating HIV-1 infection. Particular attention has been directed toward gaining a more precise understanding of the early events in transmission focusing on that critical window of time when HIV first establishes infection in the host. Here we describe some of the recent findings involving HIV-1 envelope interactions with cell surface receptors that are relevant to transmission and which may represent new opportunities to develop strategies to prevent HIV infection.
authors: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. ccicala@niaid.nih.gov.
authors: Claudia
authors: C
authors: Cicala
authors: Fatima
authors: F
authors: Nawaz
authors: Katija
authors: K
authors: Jelicic
authors: James
authors: J
authors: Arthos
authors: Anthony S
authors: AS
authors: Fauci
mesh_terms: D016915:AIDS Vaccines / Q000494:pharmacology*; D055808:Drug Discovery; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D006801:Humans; D011956:Receptors, Cell Surface / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D016915:AIDS Vaccines; D015699:HIV Envelope Protein gp120; D011956:Receptors, Cell Surface; C514793:gp120 protein, Human immunodeficiency virus 1