title: Apple juice attenuates genotoxicity and oxidative stress induced by cadmium exposure in multiple organs of rats.
abstract: The aim of this study was to evaluate the health benefits associated with apple consumption following cadmium exposure. A total of 15 Wistar rats were distributed into three groups (n=5), as follows: control group (non-treated group, CTRL); cadmium group (Cd) and apple juice group (Cd+AJ). The results showed a decrease in the frequency micronucleated cells in bone marrow and hepatocytes in the group exposed to cadmium and treated with apple juice. Apple juice was also able to reduce the 8OHdG levels and to decrease genetic damage in liver and peripheral blood cells. Catalase (CAT) was decreased following apple juice intake. Taken together, our results demonstrate that apple juice seems to be able to prevent genotoxicity and oxidative stress induced by cadmium exposure in multiple organs of Wistar rats.
authors: Department of Pathology, Federal University of Sao Paulo, UNIFESP, SP, Brazil.
authors: Carolina Foot
authors: CF
authors: Gomes de Moura
authors: Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil.
authors: Flávia Andressa
authors: FA
authors: Pidone Ribeiro
authors: Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil.
authors: Gabriela
authors: G
authors: Lucke
authors: Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil.
authors: Andrea Pitelli
authors: AP
authors: Boiago Gollucke
authors: Department of Pathology, Federal University of Sao Paulo, UNIFESP, SP, Brazil.
authors: Celina Tizuko
authors: CT
authors: Fujiyama Oshima
authors: Department of Pathology, Federal University of Sao Paulo, UNIFESP, SP, Brazil; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil. Electronic address: daribeiro@unifesp.br.
authors: Daniel Araki
authors: DA
authors: Ribeiro
mesh_terms: D000818:Animals; D001628:Beverages; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity*; D002452:Cell Count; D020552:Comet Assay; D005786:Gene Expression Regulation / Q000187:drug effects; D007150:Immunohistochemistry; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D027845:Malus / Q000737:chemistry*; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D009928:Organ Specificity / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D017208:Rats, Wistar; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D009153:Mutagens; D002104:Cadmium
keywords: Apple juice; Cadmium; Genotoxicity; Oxidative stress