title: miR-140-5p inhibits ovarian cancer growth partially by repression of PDGFRA.
abstract: Dysregulation of miRNAs is a common feature in human cancers, and miR-140-5p has been found to be down-regulated in cancer. However its role in ovarian cancer remains unclear. miR-140-5p was underexpressed in HCC tissues and cell lines compared with their normal controls. Additionally, PDGFRA was predicted the target gene of miR-140-5p. PDGFRA was inversely correlated with the expression of miR-140-5p in ovarian cancer cells. Importantly, we demonstrate that the over expression of miR-140-5p significantly inhibits ovarian cancer cell proliferation and induces apoptosis. Our results suggest the existence of a novel miR-140-5p-PDGFRA pathway and indicate that miR-140-5p acts as a tumor suppressor during ovarian carcinogenesis. These results may provide a promising alterative strategy for the therapeutic treatment of ovarian cancer.
authors: Department of Gynecology, People's Hospital of Hainan Province, Haikou, China.
authors: Hong
authors: H
authors: Lan
authors: Department of Radiology, People's Hospital of Hainan Province, 19 Xinhua Road, Haikou 570311, China. Electronic address: wangsheng_chen@126.com.
authors: Wangsheng
authors: W
authors: Chen
authors: Department of Gynecology, People's Hospital of Hainan Province, Haikou, China.
authors: Guoli
authors: G
authors: He
authors: Department of Gynecology, People's Hospital of Hainan Province, Haikou, China.
authors: Shuying
authors: S
authors: Yang
mesh_terms: D020413:3' Untranslated Regions; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D001665:Binding Sites; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D034622:RNA Interference; D012323:RNA Processing, Post-Transcriptional; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors; D014162:Transfection
chemical_list: D020413:3' Untranslated Regions; D000970:Antineoplastic Agents; D035683:MicroRNAs; C544302:Mirn140 microRNA, human; D020796:Receptor, Platelet-Derived Growth Factor alpha; D002945:Cisplatin
keywords: Ovarian cancer; PDGFRA; miR-140-5p