title: Difference in Outcomes between First-Operated vs. Fellow-Operated Eyes in Patients Undergoing Bilateral Trabeculectomies.
abstract: OBJECTIVE
  To compare the course and outcome of first- and fellow-operated eyes in patients who underwent bilateral trabeculectomies and to investigate the factors associated with the difference.
  
  
  METHODS
  Preoperative characteristics, including the interval between surgeries, were compared between the first- and fellow-operated eyes in 42 patients who underwent bilateral trabeculectomies. Postoperative intraocular pressure and bleb vascularity, using postoperative anterior segment photos, were compared at various time points between the first- and fellow-operated eyes. Surgical success was evaluated at 1 year after surgery and at the final follow-up. Factors affecting the difference between the first and fellow eyes were analyzed.
  
  
  RESULTS
  There was no significant difference in success or failure rates at 1 year postoperatively and at the final follow-up between the first- and fellow-operated eyes. Early postoperative IOP and the degree of bleb vascularity were higher in the fellow-operated eyes (P = 0.001 and 0.003, respectively at week 1 postoperative). The difference in IOP between the first- and fellow-operated eyes was greater in patients whose interval between surgeries was shorter than 3 weeks (P = 0.026).
  
  
  CONCLUSIONS
  In patients undergoing bilateral trabeculectomies, early postoperative IOP was higher in the fellow-operated eyes than the first-operated eyes; the difference was greater when the interval between surgeries was shorter. The first-operated eye may influence the early postoperative inflammatory response in the fellow-operated eye. Our findings have clinical implications for planning treatment of patients who may need bilateral surgery.
authors: Department of Ophthalmology and Visual Science, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors: Younhea
authors: Y
authors: Jung
authors: Department of Ophthalmology and Visual Science, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors: Hae-Young L
authors: HY
authors: Park
authors: Department of Ophthalmology and Visual Science, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
authors: Na Young
authors: NY
authors: Lee
authors: Department of Convergence Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Young-Sik
authors: YS
authors: Yoo
authors: Department of Ophthalmology and Visual Science, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors: Chan Kee
authors: CK
authors: Park
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005901:Glaucoma / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome