title: A new frontier for an old drug? A word of caution for beta-blockers in sepsis!
abstract: Recent promising findings indicate a possible benefit of β-blockade in septic patients. Ongoing trials on esmolol in septic shock are investigating its hemodynamic effects, focusing on heart rate control and echocardiographic changes, as well as potential anti-inflammatory effects. However, given the complex physiology of sepsis and pharmacological effects on β-blockade, large multi-center trials are essential before such a therapy may be applied safely.
authors: a a Critical Care Research Group, The University of Queensland and the Prince Charles Hospital , Brisbane , Queensland , Australia.|b b Department of Anaesthesiology and Intensive Care , Philipps University , Marburg , Germany.
authors: Marc O
authors: MO
authors: Maybauer
authors: b b Department of Anaesthesiology and Intensive Care , Philipps University , Marburg , Germany.
authors: Dirk M
authors: DM
authors: Maybauer
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D018805:Sepsis / Q000188:drug therapy*; D012772:Shock, Septic / Q000188:drug therapy*
chemical_list: D000319:Adrenergic beta-Antagonists
keywords: Beta blockers; Esmolol; Sepsis; Septic shock