title: Effects of in utero cord blood collection on post-cesarean hemoglobin levels.
abstract: OBJECTIVE
  To assess effects of in utero cord blood collection on postoperative hemoglobin, hematocrit levels.
  
  
  METHODS
  Elective cesarean deliveries in which cord blood was collected were compared with match paired elective cesarean deliveries without cord blood collection. Pre-post-operative hemoglobin and hematocrit level differences were compared between study groups with Student's t test. Multivariate regression models were used to address confounders. Correlation between volume of collected UCB and mean decrease in blood count parameters was analyzed.
  
  
  RESULTS
  A total of 399 cesarean deliveries during a 12 months period were included in the analysis. Mean decrease in hemoglobin levels was 1.08g/dL (SD=1.0) in UCB collected group compared to 0.84g/dL (SD=1.0) in control group (p=0.002). Mean decrease in hematocrit levels was 3.1% (SD=3.4) in cord blood collected cesarean delivery group compared to 1.9% (SD=2.4) in control group (p=0.002). Univariate analysis has shown the collected UCB volume to be uncorrelated with the change in hemoglobin levels (r=0.013). Multivariate regression models, after adjusting for birth weight, age and number of prior cesarean, have shown the UCB collection to be significantly associated with the mean decrease in blood count parameters (estimate=0.23g/dL, t=-2.23, p=0.02).
  
  
  CONCLUSIONS
  In utero UCB collection is associated with a small increase in bleeding of little clinical importance. Amount of UCB is not associated with amount of change in hemoglobin and hematocrit levels. In utero UCB collection seems to be safe for expectant mothers scheduled for low-risk cesarean delivery.
authors: Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey. Electronic address: ekalafat@ankara.edu.tr.
authors: Erkan
authors: E
authors: Kalafat
authors: Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey.
authors: Tuncay
authors: T
authors: Yuce
authors: Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey.
authors: Bahar
authors: B
authors: Konuralp
authors: Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey.
authors: Doruk C
authors: DC
authors: Katlan
authors: Middle East Technical University, Department of Statistics, Turkey.
authors: Zeynep
authors: Z
authors: Kalaylioglu
authors: Ankara University Faculty of Medicine, Department of Hematology and Ankara University Cord Blood Bank, Ankara, Turkey.
authors: Meral
authors: M
authors: Beksac
authors: Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey.
authors: Acar
authors: A
authors: Koc
authors: Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey.
authors: Feride
authors: F
authors: Soylemez
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical; D001810:Blood Volume; D016022:Case-Control Studies; D002585:Cesarean Section; D017218:Cordocentesis / Q000009:adverse effects*; D017558:Elective Surgical Procedures; D005260:Female; D006400:Hematocrit; D006441:Hemoglobin A / Q000378:metabolism*; D006801:Humans; D011184:Postoperative Period; D011247:Pregnancy; D057234:Preoperative Period
chemical_list: D006441:Hemoglobin A
keywords: Blood loss; Cesarean; Collection; Cord blood; Maternal hemorrhage