title: Clozapine-induced stuttering: an estimate of prevalence in the west of Ireland.
abstract: OBJECTIVE
  Clozapine is the most effective treatment available for treatment-resistant schizophrenia; however, it is also associated with a large array of adverse effects that limits its tolerability. A number of previous case reports have noted an association between clozapine and stuttering, however the rate of this possible adverse effect is yet to be established.
  
  
  METHODS
  In this paper, we present six cases of patients treated with clozapine who developed stuttering.
  
  
  RESULTS
  Clozapine was associated with stuttering in 0.92% of individuals treated with clozapine in the region. Clozapine-induced stuttering was associated with an increase in treatment dose or with dose titration at initiation of clozapine in five individuals, with dose reduction or slower dose titration associated with a cessation of stuttering in these cases.
  
  
  CONCLUSIONS
  This is the largest case series to date examining clozapine-induced stuttering and indicates that clozapine-induced stuttering is a relatively common adverse effect that can be managed by a slower titration of clozapine dosage or a modest reduction in dose in most cases.
authors: Department of Psychiatry, National University of Ireland Galway, Newcastle Road, Galway, Ireland.
authors: Ruth
authors: R
authors: Murphy
authors: Department of Psychiatry, National University of Ireland Galway, Galway, Ireland.
authors: Anne
authors: A
authors: Gallagher
authors: Department of Psychiatry, University Hospital Galway, Galway, Ireland.
authors: Kapil
authors: K
authors: Sharma
authors: Department of Psychiatry, Letterkenny General Hospital, Letterkenny, Ireland.
authors: Tariq
authors: T
authors: Ali
authors: Department of Psychiatry, Sligo General Hospital, Sligo, Ireland.
authors: Elizabeth
authors: E
authors: Lewis
authors: Department of Psychiatry, University Hospital Galway, Galway, Ireland.
authors: Ivan
authors: I
authors: Murray
authors: Department of Psychiatry, National University of Ireland Galway, Galway, Ireland.
authors: Brian
authors: B
authors: Hallahan
keywords: clozapine; speech dysfluency; stuttering