title: Genetic association between TRAIL-R1 Thr209Arg and cancer susceptibility.
abstract: We aimed to determine the indecisive association between tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) Thr209Arg polymorphism and inherited susceptibility to cancer. A meta-analysis combining data on 9,517 individuals was performed to assess the association between TRAIL-R1 Thr209Arg and cancer incidence. The summary ORs with 95% CI calculated with the fixed effects model suggested that Thr209Arg was not significantly associated with cancer susceptibility (homozygous model: OR 0.98, 95% CI 0.88-1.09; heterozygous model: OR 0.95, 95% CI 0.87-1.04; allele frequency model: OR 0.99, 95% CI 0.94-1.05; dominant model: OR 0.98, 95% CI 0.91-1.05; recessive model: OR 1.01, 95% CI 0.92-1.10). Stratified analysis by ethnicity and cancer type yielded similar null associations. These statistical data suggest that Thr209Arg in exon 4 of the TRAIL-R1 gene may not represent a modifier of susceptibility to cancer.
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Peiliang
authors: P
authors: Geng
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Jianjun
authors: J
authors: Li
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Ning
authors: N
authors: Wang
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Yunmei
authors: Y
authors: Liao
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Juanjuan
authors: J
authors: Ou
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Rina
authors: R
authors: Sa
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Ganfeng
authors: G
authors: Xie
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Chen
authors: C
authors: Liu
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Hongtao
authors: H
authors: Li
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Lisha
authors: L
authors: Xiang
authors: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.
authors: Houjie
authors: H
authors: Liang
mesh_terms: D019943:Amino Acid Substitution; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D017594:Publication Bias; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics*
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand