title: The association of ApE1 -656T>G and 1349T>G polymorphisms with breast cancer susceptibility in northern Iran.
abstract: Breast cancer is the most common cancer and one of the main causes of cancer-related death in the world and has become a major public health concern. Many genes have been shown to be involved in the progress of the breast cancer. Human apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that has an important role in the base excision repair (BER) pathway. The aim of this study was to evaluate the association between ApE1 -656T>G and 1349T>G polymorphisms and the susceptibility to breast cancer in northern Iran population. Samples were obtained from 150 patients diagnosed with breast cancer and 150 control subjects and genotyped by tetra - primer amplification refractory mutation system PCR (T-ARMS-PCR). We observed a significant difference in genotype distributions of -656T>G polymorphism between patients and controls (P= 0.03). Findings indicated that individuals with the variant TG genotypes had a significant decreased risk of breast cancer (OR= 0.55, 95% CI= 0.33 - 0.91, P= 0.019). However, the significant association between 1349T>G polymorphism and breast cancer risk was not observed (P = 0.89). Larger studies are needed to confirm our results.
authors: University of Guilan Department of Biology, Faculty of Sciences Rasht Iran mashayekhi&commat;guilan.ac.ir.
authors: F
authors: F
authors: Mashayekhi
authors: University of Guilan Department of Biology, Faculty of Sciences Rasht Iran.
authors: M
authors: M
authors: Yousefi
authors: University of Guilan Department of Biology, Faculty of Sciences Rasht Iran.
authors: Z
authors: Z
authors: Salehi
authors: Guilan University of Medical Sciences Department of Radiotherapy, Faculty of Medicine Rasht Iran.
authors: H S
authors: HS
authors: Saedi
authors: University of Guilan Department of Biology, Faculty of Sciences Rasht Iran.
authors: M
authors: M
authors: Pournourali
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase