title: Increased neutralization capacity of TNF-α in sera of relapsing remitting multiple sclerosis patients is not related to soluble TNF-α receptors or anti-TNF-α autoantibody levels.
abstract: The increased TNF-α levels in active lesions and CSF of multiple sclerosis (MS) patients and the beneficial effect of TNF-α blockade in animal models of MS led to the therapeutic usage of TNF-α antagonists. However, systemic TNF-α blockade exacerbated MS activity and was associated with new-onset MS when implemented for treating other autoimmune disorders. We employed a TNF-α neutralization bioassay and demonstrated that the capacity of sera from untreated and IFN-β-treated relapsing remitting MS patients to neutralize TNF-α is significantly higher than that of matched healthy controls. This finding was not related to sTNFRI, sTNFRII, or anti-TNF-α Abs levels.
authors: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors: Karin
authors: K
authors: Mausner-Fainberg
authors: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors: Keren
authors: K
authors: Regev
authors: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors: Hadar
authors: H
authors: Kolb
authors: Department of Neurology and Laboratory of Neuroimmunology, Agnes-Ginges Center for Neurogenetics, Hadassah Medical Center, Ein-Karem, Jerusalem, Israel.
authors: Adi
authors: A
authors: Vaknin-Dembinsky
authors: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler's Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: arnonk@tlvmc.gov.il.
authors: Arnon
authors: A
authors: Karni
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000188:drug therapy; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000276:immunology*; D055815:Young Adult
chemical_list: D000906:Antibodies; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D016899:Interferon-beta
keywords: Anti-TNF-α autoantibodies; Multiple sclerosis; Soluble TNF receptors; TNF-α neutralization; Tumor necrosis factor α