title: Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases.
abstract: Coenzyme Q10 (CoQ10) is a component of electron transport chain and acts as an antioxidant. It is also used for preventing neurodegeneration against mitochondrial deficiency and oxidative stress. Therefore, CoQ10 has received increasing attention as therapeutic and preventive intervention for neurodegenerative diseases. This review article focuses mainly on the structure of CoQ10, the function of CoQ10 and the relationship between mitochondrial impairment, oxidative stress and neurodegenerative diseases. In addition, the effects of CoQ10 on Alzheimer's disease, Parkinson's disease, and Huntington's disease are also discussed. Finally, future perspectives regarding development of successful treatment for neurodegenerative diseases are proposed.
authors: Key Laboratory of Modern Toxicology of Shenzhen, Medical Key Laboratory of Guangdong Province, Medical Key Laboratory of Health Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China. xifeiyang@gmail.com.
authors: Xifei
authors: X
authors: Yang
authors: Yanling
authors: Y
authors: Zhang
authors: Hua
authors: H
authors: Xu
authors: Xiaobin
authors: X
authors: Luo
authors: Jun
authors: J
authors: Yu
authors: Jianjun
authors: J
authors: Liu
authors: Raymond Chuen-Chung
authors: RC
authors: Chang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D000066829:Neuroprotection; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D018696:Neuroprotective Agents; D014451:Ubiquinone; C024989:coenzyme Q10