title: Management of Dynamic Biomedical Terminologies: Current Status and Future Challenges.
abstract: OBJECTIVE
  Controlled terminologies and their dependent artefacts provide a consensual understanding of a domain while reducing ambiguities and enabling reasoning. However, the evolution of a domain's knowledge directly impacts these terminologies and generates inconsistencies in the underlying biomedical information systems. In this article, we review existing work addressing the dynamic aspect of terminologies as well as their effects on mappings and semantic annotations.
  
  
  METHODS
  We investigate approaches related to the identification, characterization and propagation of changes in terminologies, mappings and semantic annotations including techniques to update their content.
  
  
  CONCLUSIONS
  Based on the explored issues and existing methods, we outline open research challenges requiring investigation in the near future.
authors: Dr. Marcos Da Silveira, Luxembourg Institute of Science and Technology (LIST), 5, avenue des Hauts-Fourneaux, 4362 Esch/Alzette, Luxembourg, E-mail: marcos.dasilveira@list.lu.
authors: M
authors: M
authors: Da Silveira
authors: J C
authors: JC
authors: Dos Reis
authors: C
authors: C
authors: Pruski
mesh_terms: D001185:Artificial Intelligence; D058436:Knowledge Management; D012660:Semantics; D018875:Vocabulary, Controlled
keywords: Knowledge management; biomedical ontologies; knowledge representation; ontology evolution