title: Practice innovation: the need for nimble data platforms to implement precision oncology care.
abstract: Given the drive toward personalized, value-based, and coordinated cancer care delivery, modern knowledge-based practice is being shaped within the context of an increasingly technology-driven healthcare landscape. The ultimate promise of 'precision medicine' is predicated on taking advantage of the range of new capabilities for integrating disease- and individual-specific data to define new taxonomies as part of a systems-based knowledge network. Specifically, with cancer being a constantly evolving complex disease process, proper care of an individual will require the ability to seamlessly integrate multi-dimensional 'omic' and clinical data. Importantly, however, the challenges of curating knowledge from multiple dynamic data sources and translating to practice at the point-of-care highlight parallel needs. As patients, caregivers, and their environments become more proactive in clinical care and management, practical success of precision medicine is equally dependent on the development of proper infrastructures for evolving data integration, platforms for knowledge representation in a clinically-relevant context, and implementation within a provider's work-life and workflow.
authors: Dana-Farber Cancer Institute; Brigham and Women's Hospital; Harvard Medical School, Boston, MA 02215, USA.
authors: Aymen
authors: A
authors: Elfiky
authors: Dongyang
authors: D
authors: Zhang
authors: Hari K
authors: HK
authors: Krishnan Nair
mesh_terms: D006801:Humans; D051188:Knowledge Bases; D008297:Male; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D057285:Precision Medicine / Q000379:methods*; D057170:Translational Research, Biomedical / Q000379:methods*