title: Association Between Changes in Serum 5-Hydroxy-Tryptamine Concentrations and Improvement in Clinical Symptoms in Primary Premature Ejaculation with Paroxetine Treatment.
abstract: BACKGROUND
  This study aimed to investigate the association between changes in serum 5-hydroxy tryptamine (5-HT) concentrations and improvement in clinical symptoms in primary premature ejaculation with paroxetine treatment.
  
  
  METHODS
  A total of 142 men aged 18-65 years with a history of lifelong premature ejaculation and an intravaginal ejaculation latency time (IELT) <120 s were included in this study. Patients were divided into 3 groups according to IELT: IELT ≤30 s (group A), (IELT >30 s and ≤60 s (group B), and IELT >60 s and <120 s (group C). Patients in the 3 groups were administered paroxetine hydrochloride 20 mg/d for 8 weeks. Blood samples were obtained from the candidates in the screening period and after 8 weeks of treatment. Plasma 5-hydroxy-tryptamine (5-HT) concentrations were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Reliable data from 125 patients were obtained. There were 41 patients in group A, 40 in group B, and 44 in Group C. IELT and serum 5-HT concentrations were significantly improved in the 3 groups after treatment (all P<0.001). The mean change and fold increase in IELT and the mean change in serum 5-HT concentrations in group A were significantly higher than those in groups B and C (all P<0.001). The mean change and fold increase in IELT and the mean change in serum 5-HT concentrations in group B were significantly higher than those in group C (all P<0.001). Significantly more patients in group A achieved clinical benefits than those in groups B and C (P<0.001).
  
  
  CONCLUSIONS
  Improvement in serum 5-HT concentrations has obvious association with primary premature ejaculation symptom improvement with paroxetine use.
authors: Department of Urology, Traditional Chinese Medicine Hospital, Chongqing, China (mainland).
authors: Yu
authors: Y
authors: Guo
authors: Department of Urology, Traditional Chinese Medicine Hospital, Chongqing, China (mainland).
authors: You
authors: Y
authors: Wang
authors: Department of Urology, Traditional Chinese Medicine Hospital, Chongqing, China (mainland).
authors: Xi
authors: X
authors: Wang
authors: Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, China (mainland).
authors: Gang
authors: G
authors: Ye
authors: Department of Urology, Traditional Chinese Medicine Hospital, Chongqing, China (mainland).
authors: Yuanbin
authors: Y
authors: Jiang
authors: Department of Urology, Traditional Chinese Medicine Hospital, Chongqing, China (mainland).
authors: Wei
authors: W
authors: Xiong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D004542:Ejaculation / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000627:therapeutic use*; D061686:Premature Ejaculation / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D012701:Serotonin / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D017374:Paroxetine; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors