title: Near-Infrared Spatially Resolved Spectroscopy for Tablet Quality Determination.
abstract: Near-infrared (NIR) spectroscopy has become a well-established tool for the characterization of solid oral dosage forms manufacturing processes and finished products. In this work, the utility of a traditional single-point NIR measurement was compared with that of a spatially resolved spectroscopic (SRS) measurement for the determination of tablet assay. Experimental designs were used to create samples that allowed for calibration models to be developed and tested on both instruments. Samples possessing a poor distribution of ingredients (highly heterogeneous) were prepared by under-blending constituents prior to compaction to compare the analytical capabilities of the two NIR methods. The results indicate that SRS can provide spatial information that is usually obtainable only through imaging experiments for the determination of local heterogeneity and detection of abnormal tablets that would not be detected with single-point spectroscopy, thus complementing traditional NIR measurement systems for in-line, and in real-time tablet analysis.
authors: Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania.
authors: Benoît
authors: B
authors: Igne
authors: Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282.
authors: Sameer
authors: S
authors: Talwar
authors: Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282.
authors: Hanzhou
authors: H
authors: Feng
authors: Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282.
authors: James K
authors: JK
authors: Drennen
authors: Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282. Electronic address: andersonca@duq.edu.
authors: Carl A
authors: CA
authors: Anderson
mesh_terms: D002138:Calibration; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013607:Tablets / Q000737:chemistry*
chemical_list: D013607:Tablets
keywords: chemometrics; content uniformity; diffuse reflectance; multivariate analysis; near-infrared spectroscopy; partial least squares; spatially resolved spectroscopy; tableting