title: The microbial community structure of the cotton rat nose.
abstract: The cotton rat nose is commonly used as a model for Staphylococcus aureus colonization, as it is both physiologically and anatomically comparable to the human nares and can be easily colonized by this organism. However, while the colonization of the human anterior nares has been extensively studied, the microbial community structure of cotton rat noses has not been reported so far. We describe here the microbial community structure of the cotton rat (Sigmodon hispidus) nose through next-generation sequencing of 16S rRNA gene amplicons covering the V1-V2 region and the analysis of nearly full length 16S rRNA genes of the major phylotypes. Roughly half of the microbial community was composed of two undescribed species of the genus Campylobacter, with phylotypes belonging to the genera Catonella, Acholeplasma, Streptobacillus and Capnocytophaga constituting the predominant community members. Thus, the nasal community of the cotton rat is uniquely composed of several novel bacterial species and may not reflect the complex interactions that occur in human anterior nares. Mammalian airway microbiota may, however, be a rich source of hitherto unknown microbes.
authors: Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.
authors: Diego
authors: D
authors: Chaves-Moreno
authors: Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.
authors: Iris
authors: I
authors: Plumeier
authors: Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.
authors: Silke
authors: S
authors: Kahl
authors: Interfaculty Institute of Microbiology and Infection Medicine, Cellular and Molecular Microbiology, Eberhard-Karls-University, Geschwister-Scholl-Platz, 72074, Tübingen, Germany.|German Center for Infection Research, Partner Site Tübingen, Tübingen, Germany.
authors: Bernhard
authors: B
authors: Krismer
authors: Interfaculty Institute of Microbiology and Infection Medicine, Cellular and Molecular Microbiology, Eberhard-Karls-University, Geschwister-Scholl-Platz, 72074, Tübingen, Germany.|German Center for Infection Research, Partner Site Tübingen, Tübingen, Germany.
authors: Andreas
authors: A
authors: Peschel
authors: Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.
authors: Andrew P A
authors: AP
authors: Oxley
authors: Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.
authors: Ruy
authors: R
authors: Jauregui
authors: Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.
authors: Dietmar H
authors: DH
authors: Pieper
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification / Q000235:genetics; D044822:Biodiversity; D054892:Metagenome; D056186:Metagenomics; D064307:Microbiota; D009666:Nose / Q000382:microbiology*; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D016205:Sigmodontinae / Q000382:microbiology*
chemical_list: D012336:RNA, Ribosomal, 16S