title: Sequential (as Opposed to Simultaneous) Antibiotic Therapy Improves Helicobacter pylori Eradication in the Pediatric Population: A Meta-Analysis.
abstract: Helicobacter pylori is a common infection associated with many gastrointestinal diseases. Triple or quadruple therapy is the current recommendation for H pylori eradication in children but is associated with success rates as low as 50%. Recent studies have demonstrated that a 10-day sequential therapy regimen, rather than simultaneous antibiotic administration, achieved eradication rates of nearly 95%. This meta-analysis found that sequential therapy increased eradication rates by 14.2% (relative risk [RR] = 1.142; 95% confidence interval [CI] = 1.082-1.207; P < .001). Ten-day sequential therapy significantly improved H pylori eradication rates compared to the 7-day standard therapy (RR = 1.182; 95% CI = 1.102-1.269; p < .001) and 10-day standard therapy (RR = 1.179; 95% CI = 1.074-1.295; P = .001), but had lower eradication rates compared to 14-day standard therapy (RR = 0.926; 95% CI = 0.811-1.059; P = .261). The use of sequential therapy is associated with increased H pylori eradication rates in children compared to standard therapy of equal or shorter duration.
authors: Saint Barnabas Medical Center, Livingston, NJ, USA Saint George's University School of Medicine, Grenada, West Indies.
authors: Christine S M
authors: CS
authors: Lau
authors: Saint George's University School of Medicine, Grenada, West Indies.
authors: Amanda
authors: A
authors: Ward
authors: Saint Barnabas Medical Center, Livingston, NJ, USA Saint George's University School of Medicine, Grenada, West Indies New Jersey Medical School, Rutgers University, Newark, NJ, USA rchamberlain@barnabashealth.org.
authors: Ronald S
authors: RS
authors: Chamberlain
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents
keywords: Helicobacter pylori; children; concomitant therapy; sequential therapy; standard triple therapy