title: Global gene expression by Bacillus anthracis during growth in mammalian blood.
abstract: During the late stages of systemic anthrax, Bacillus anthracis grows rapidly in the host bloodstream. To identify potential genes necessary for this observed rapid growth, we defined the transcriptional profile of B. anthracis during in vitro growth in bovine blood. Genome-wide transcriptome analysis indicated that B. anthracis undergoes significant changes in its transcriptome profile during growth in blood, including the differential regulation of genes associated both with metabolism and known virulence factors. Collectively, these data provide a framework for future studies identifying specific B. anthracis factors required for growth in the mammalian bloodstream.
authors: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
authors: Paul E
authors: PE
authors: Carlson
authors: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
authors: Alexandra E T
authors: AE
authors: Bourgis
authors: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
authors: Ada K
authors: AK
authors: Hagan
authors: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48104, USA pchanna@umich.edu.
authors: Philip C
authors: PC
authors: Hanna
mesh_terms: D000818:Animals; D001408:Bacillus anthracis / Q000235:genetics* / Q000254:growth & development*; D001769:Blood / Q000382:microbiology*; D002417:Cattle; D020869:Gene Expression Profiling
keywords: Bacillus anthracis; blood growth; macrophage; transcriptome