title: Mangosenone F, A Furanoxanthone from Garciana mangostana, Induces Reactive Oxygen Species-Mediated Apoptosis in Lung Cancer Cells and Decreases Xenograft Tumor Growth.
abstract: Mangosenone F (MSF), a natural xanthone, was isolated form Carcinia mangotana, and a few studies have reported its glycosidase inhibitor effect. In this study we investigated the anti lung cancer effect of MSF both in vitro and in vivo. MSF inhibited cancer cell cytotoxicity and induced and induced apoptosis via reactive oxygen species (ROS) generation in NCI-H460. MSF treatment also showed in pronounced release of apoptogenic cytochrome c from the mitochondria to the cytosol, downregulation of Bcl-2 and Bcl-xL, and upregulation of Bax, suggesting that caspase-mediated pathways were involved in MSF-induced apoptosis. ROS activation of the mitogen-activated protein kinase signaling pathway was shown to play a predominant role in the apoptosis mechanism of MSF. Compared with cisplatin treatment, MSF treatment showed significantly increased inhibition of the growth of NCI-H460 cells xenografted in nude mice. Together, these results indicate the potential of MSF as a candidate natural anticancer drug by promoting ROS production.
authors: Crop Foundation Division, National Institue of Crop Science, Rural Development Administration, Wanju-Gun, Jeollabuk-do, 565-851, Republic of Korea.
authors: Kyung Hye
authors: KH
authors: Seo
authors: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, 363-883, Republic of Korea.
authors: Hyung Won
authors: HW
authors: Ryu
authors: Division of Applied Biosciences College of Agriculture and Life Sciences, Kyungpook National University, Daegu, 702-701, Republic of Korea.
authors: Mi Jin
authors: MJ
authors: Park
authors: Division of Applied Life Science (BK21 program), Institute of Agriculture and Life Science, Graduate School of Gyeongsang National University, Jinju, 660-701, Republic of Korea.
authors: Ki Hun
authors: KH
authors: Park
authors: Division of Applied Life Science (BK21 program), Institute of Agriculture and Life Science, Graduate School of Gyeongsang National University, Jinju, 660-701, Republic of Korea.
authors: Jin Hyo
authors: JH
authors: Kim
authors: Crop Foundation Division, National Institue of Crop Science, Rural Development Administration, Wanju-Gun, Jeollabuk-do, 565-851, Republic of Korea.
authors: Mi-Ja
authors: MJ
authors: Lee
authors: Crop Foundation Division, National Institue of Crop Science, Rural Development Administration, Wanju-Gun, Jeollabuk-do, 565-851, Republic of Korea.
authors: Hyeon Jung
authors: HJ
authors: Kang
authors: Crop Foundation Division, National Institue of Crop Science, Rural Development Administration, Wanju-Gun, Jeollabuk-do, 565-851, Republic of Korea.
authors: Sun Lim
authors: SL
authors: Kim
authors: National Institute of Chemical Safety, Ministry of Environment, Daejeon, 305-343, Republic of Korea.
authors: Jin Hwan
authors: JH
authors: Lee
authors: Crop Foundation Division, National Institue of Crop Science, Rural Development Administration, Wanju-Gun, Jeollabuk-do, 565-851, Republic of Korea.
authors: Woo Duck
authors: WD
authors: Seo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D045304:Cytochromes c / Q000378:metabolism; D029762:Garcinia mangostana; D064593:Heterografts; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D008928:Mitochondria / Q000187:drug effects; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D044004:Xanthones / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species; D044004:Xanthones; D045304:Cytochromes c; D020928:Mitogen-Activated Protein Kinases; D020169:Caspases; D002945:Cisplatin
keywords: ROS; apoptosis; caspase; lung cancer cell; mangosenone F; xenografted nude mice