title: Production of scandium-44 m and scandium-44 g with deuterons on calcium-44: cross section measurements and production yield calculations.
abstract: HIGHLIGHTS • Production of Sc-44 m, Sc-44 g and contaminants. • Experimental values determined using the stacked-foil technique. • Thick-Target production Yield (TTY) calculations. • Comparison with the TALYS code version 1.6.Among the large number of radionuclides of medical interest, Sc-44 is promising for PET imaging. Either the ground-state Sc-44 g or the metastable-state Sc-44 m can be used for such applications, depending on the molecule used as vector. This study compares the production rates of both Sc-44 states, when protons or deuterons are used as projectiles on an enriched Calcium-44 target. This work presents the first set of data for the deuteron route. The results are compared with the TALYS code. The Thick-Target production Yields of Sc-44 m and Sc-44 g are calculated and compared with those for the proton route for three different scenarios: the production of Sc-44 g for conventional PET imaging, its production for the new 3 γ imaging technique developed at the SUBATECH laboratory and the production of a Sc-44 m/Sc-44 g in vivo generator for antibody labelling.
authors: SUBATECH, Ecole des Mines de Nantes, Université de Nantes, CNRS/IN2P3, Nantes, France.
authors: C
authors: C
authors: Duchemin
authors: A
authors: A
authors: Guertin
authors: F
authors: F
authors: Haddad
authors: N
authors: N
authors: Michel
authors: V
authors: V
authors: Métivier
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry*; D017357:Cyclotrons; D003903:Deuterium / Q000737:chemistry*; D049268:Positron-Emission Tomography; D011854:Radiochemistry / Q000295:instrumentation*; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012538:Scandium / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; D003903:Deuterium; D002119:Calcium Carbonate; D012538:Scandium