title: Sensititre MycoTB plate compared to Bactec MGIT 960 for first- and second-line antituberculosis drug susceptibility testing in Tanzania: a call to operationalize MICs.
abstract: MIC testing for Mycobacterium tuberculosis is now commercially available. Drug susceptibility testing by the MycoTB MIC plate has not been directly compared to that by the Bactec MGIT 960. We describe a case of extensively drug-resistant tuberculosis (XDR-TB) in Tanzania where initial MIC testing may have prevented acquired resistance. From testing on archived isolates, the accuracy with the MycoTB plate was >90% for important first- and second-line drugs compared to that with the MGIT 960, and clinically useful quantitative interpretation was also provided.
authors: Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA skh8r@virginia.edu.
authors: Scott K
authors: SK
authors: Heysell
authors: Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
authors: Suporn
authors: S
authors: Pholwat
authors: Kibong'oto Infectious Diseases Hospital, Sanya Juu, Tanzania.
authors: Stellah G
authors: SG
authors: Mpagama
authors: Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
authors: Saumu J
authors: SJ
authors: Pazia
authors: Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
authors: Happy
authors: H
authors: Kumburu
authors: Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
authors: Norah
authors: N
authors: Ndusilo
authors: Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
authors: Jean
authors: J
authors: Gratz
authors: Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
authors: Eric R
authors: ER
authors: Houpt
authors: Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
authors: Gibson S
authors: GS
authors: Kibiki
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D054908:Extensively Drug-Resistant Tuberculosis / Q000235:genetics; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D013636:Tanzania
chemical_list: D000995:Antitubercular Agents