title: Increased Circulating Cathepsin K in Patients with Chronic Heart Failure.
abstract: Cysteinyl cathepsin K (CatK) is one of the most potent mammalian collagenases involved in cardiovascular disease. Here, we investigated the clinical predictive value of serum CatK levels in patients with chronic heart failure (CHF). We examined 134 patients with CHF, measuring their serum CatK, troponin I, high-sensitive C-reactive protein, and pre-operative N-terminal pro-brain natriuretic peptide levels. The patients were divided into two groups: the 44 patients who showed a left ventricular (LV) ejection fraction (LVEF) < 40% (the "lowLVEF" group) and the 90 patients showing LVEF values ≥ 40% (the "highLVEF" group). The lowLVEF patients had significantly higher serum CatK levels compared to the highLVEF patients (58.4 ± 12.2 vs. 44.7 ± 16.4, P < 0.001). Overall, a linear regression analysis showed that CatK levels correlated negatively with LVEF (r = -0.4, P < 0.001) and positively with LV end-diastolic dimensions (r = 0.2, P < 0.01), LV end-systolic dimensions (r = 0.3, P < 0.001), and left atrial diameters (r = 0.3, P < 0.01). A multiple logistic regression analysis showed that CatK levels were independent predictors of CHF (odds ratio, 0.90; 95% confidence interval, 0.84-0.95; P < 0.01). These data indicate that elevated levels of CatK are closely associated with the presence of CHF and that the measurement of circulating CatK provides a noninvasive method of documenting and monitoring the extent of cardiac remodeling and dysfunction in patients with CHF.
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Guangxian
authors: G
authors: Zhao
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Yuzi
authors: Y
authors: Li
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Lan
authors: L
authors: Cui
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Xiang
authors: X
authors: Li
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Zhenyi
authors: Z
authors: Jin
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Xiongyi
authors: X
authors: Han
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Ennan
authors: E
authors: Fang
authors: Department of Clinical Examination, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Yihua
authors: Y
authors: Gao
authors: Department of Central Laboratory, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Dongmei
authors: D
authors: Zhou
authors: Department of Physiology and Pathophysiology, Yanbian University Medical College, Yanji, Jilin, P.R., China.
authors: Haiying
authors: H
authors: Jiang
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Xueying
authors: X
authors: Jin
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Guanghao
authors: G
authors: Piao
authors: Department of Central Laboratory, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Xiangshan
authors: X
authors: Li
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Guang
authors: G
authors: Yang
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Jiyong
authors: J
authors: Jin
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Enbo
authors: E
authors: Zhu
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Meina
authors: M
authors: Piao
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Limei
authors: L
authors: Piao
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Kuichang
authors: K
authors: Yuan
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Yanna
authors: Y
authors: Lei
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Dazhi
authors: D
authors: Ding
authors: Department of Clinical Examination, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Chengzhi
authors: C
authors: Jin
authors: Department of Anesthesiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Yongshan
authors: Y
authors: Nan
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin, P.R., China.
authors: Xianwu
authors: X
authors: Cheng
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D056657:Cathepsin K / Q000097:blood*; D004452:Echocardiography; D005109:Extracellular Matrix / Q000235:genetics; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008074:Lipoproteins; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D012044:Regression Analysis; D019210:Troponin I / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000503:physiopathology
chemical_list: D008074:Lipoproteins; D019210:Troponin I; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein; D056657:Cathepsin K