title: Cell Therapy in Patients with Critical Limb Ischemia.
abstract: Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.
authors: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.
authors: Rita
authors: R
authors: Compagna
authors: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy ; Department of General, Geriatric, Oncologic Surgery and Advanced Technologies, University of Naples "Federico II", 80100 Naples, Italy.
authors: Bruno
authors: B
authors: Amato
authors: Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.
authors: Salvatore
authors: S
authors: Massa
authors: Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.
authors: Maurizio
authors: M
authors: Amato
authors: Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Raffaele
authors: R
authors: Grande
authors: Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Lucia
authors: L
authors: Butrico
authors: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Stefano
authors: S
authors: de Franciscis
authors: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Raffaele
authors: R
authors: Serra