title: Catabolite control protein A has an important role in the metabolic regulation of Streptococcus suis type 2 according to iTRAQ-based quantitative proteomic analysis.
abstract: The catabolite control protein A (ccpA) regulates the carbon metabolism in Streptococcus suis type 2 and has pleiotropic regulatory functions in bacterial virulence and transcription. The present study systematically investigated ccpA activity in Streptococcus suis type 2 using isobaric tag for relative and absolute quantification (iTRAQ) liquid chromatography‑tandem mass spectrometry‑based proteomics. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses demonstrated that ccpA is an important protein for the regulation of metabolism, virulence and immune pathways in Streptococcus suis type 2. The present study therefore expanded the current understanding of the effects of ccpA on virulence, metabolic regulation and transcription in Streptococcus suis type 2 and other important pathogens.
authors: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors: Xulong
authors: X
authors: Lang
authors: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors: Zhonghai
authors: Z
authors: Wan
authors: Department of Orthodontics, Changchun Stomatological Hospital, Changchun, Jilin 130042, P.R. China.
authors: Ying
authors: Y
authors: Pan
authors: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors: Zhaoyang
authors: Z
authors: Bu
authors: School of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China.
authors: Xiuran
authors: X
authors: Wang
authors: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors: Xiaoxu
authors: X
authors: Wang
authors: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors: Xue
authors: X
authors: Ji
authors: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors: Lingwei
authors: L
authors: Zhu
authors: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors: Jiayu
authors: J
authors: Wan
authors: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors: Yang
authors: Y
authors: Sun
authors: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China.
authors: Xinglong
authors: X
authors: Wang
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D009154:Mutation; D040901:Proteomics; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D017011:Streptococcus suis / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D001426:Bacterial Proteins; D012097:Repressor Proteins; C069286:catabolite control proteins, bacteria