title: Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children.
abstract: BACKGROUND
  The therapeutic scheme of triclabendazole (TCBZ), the recommended anthelmintic against Fasciola hepatica , involves 10mg/kg of body weight administered in a single dose; however, clinical trials in children are scarce. We evaluated the efficacy and tolerability of 2 schemes of TCBZ.
  
  
  METHODS
  Eighty-four Peruvian children with F. hepatica eggs in their stools were allocated into 2 groups: 44 received 2 dosages of 7.5mg/kg each with a 12-h interval (Group I), and 40 received a single 10-mg/kg dose (Group II). Evaluation of efficacy was based on the presence of eggs in stools, and tolerability was based on the presence of symptoms and signs post-treatment.
  
  
  RESULTS
  A parasitological cure was obtained in 100% of individuals from Group I and 95% of individuals from Group II. The most common adverse event was biliary colic.
  
  
  CONCLUSIONS
  The tested scheme was efficacious and tolerable, and it might be an optimal scheme in the region. To the best of our knowledge, this represents the largest series of children treated with TCBZ in a non-hospital setting.
authors: Institute of Tropical Medicine Alexander von Humboldt, Cayetano Heredia University, Lima, PE.
authors: Vicente
authors: V
authors: Maco
authors: Institute of Tropical Medicine Alexander von Humboldt, Cayetano Heredia University, Lima, PE.
authors: Luis
authors: L
authors: Marcos
authors: Health Care Center of Progreso, Asillo Azángaro, Puno, PE.
authors: Jaime
authors: J
authors: Delgado
authors: Health Care Center of Canta, Lima, PE.
authors: Julio
authors: J
authors: Herrera
authors: Health Care Center of Canta, Lima, PE.
authors: José
authors: J
authors: Nestares
authors: Institute of Tropical Medicine Alexander von Humboldt, Cayetano Heredia University, Lima, PE.
authors: Angelica
authors: A
authors: Terashima
authors: Institute of Tropical Medicine Alexander von Humboldt, Cayetano Heredia University, Lima, PE.
authors: Frine
authors: F
authors: Samalvides
authors: Institute of Tropical Medicine Alexander von Humboldt, Cayetano Heredia University, Lima, PE.
authors: Eduardo
authors: E
authors: Gotuzzo
mesh_terms: D000293:Adolescent; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000009:adverse effects; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D004334:Drug Administration Schedule; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000188:drug therapy*; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D008297:Male; D010270:Parasite Egg Count; D010568:Peru; D012720:Severity of Illness Index; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole