title: Complete resistance after maximal dose of rocuronium.
abstract: Rocuronium is a non-depolarizing neuromuscular blocking agent (NDNMBA), employed in the clinic as an adjunct to general anesthesia to facilitate tracheal intubation rapid sequence, and to provide skeletal muscle relaxation during surgery. Many cases of resistance to neuromuscular blocking agents (NMBAs) have been anecdotally reported. There are specific pathologic states, such as upper motor neuron lesions, severe thermal injuries, liver disease, renal failure, disuse atrophy, all of which show an increased resistance to the effects of nondepolarizing muscle relaxants. Also concurrent drug therapy can alter the efficacy of NMBAs such as some classes of antibiotics, furosemide, β receptor agonists, phosphodiesterase inhibitors, calcium antagonists, respiratory stimulants but also ketamine, propofol and barbiturates at high concentrations. In this scenario we describe an unusual case of 20-years-old man who showed a complete resistance to rocuronium maybe due to a glucocorticoids concomitant therapy.
authors: Department of Experimental Medicine, Section of Pharmacology, Pharmacoepidemiology and Pharmacovigilance Center of the Campania Region, Second University of Naples, Caserta, Italy.
authors: Annalisa
authors: A
authors: Capuano
authors: Department of Experimental Medicine, Section of Pharmacology, Pharmacoepidemiology and Pharmacovigilance Center of the Campania Region, Second University of Naples, Caserta, Italy.
authors: Maria Giuseppa
authors: MG
authors: Sullo
authors: Department of Experimental Medicine, Section of Pharmacology, Pharmacoepidemiology and Pharmacovigilance Center of the Campania Region, Second University of Naples, Caserta, Italy.
authors: Concetta
authors: C
authors: Rafaniello
authors: Department of Experimental Medicine, Section of Pharmacology, Pharmacoepidemiology and Pharmacovigilance Center of the Campania Region, Second University of Naples, Caserta, Italy.
authors: Liberata
authors: L
authors: Sportiello
authors: Department of Anesthesia and Intensive Care, San Salvatore Hospital, L'Aquila, Italy.
authors: Pierfrancesco
authors: P
authors: Fusco
authors: Department of Anesthetic, Surgical, and Emergency Science - Intensive Care Unit, Second University of Naples, Naples, Caserta, Italy.
authors: Macella
authors: M
authors: De Vizia
authors: Department of Anesthetic, Surgical, and Emergency Science - Intensive Care Unit, Second University of Naples, Naples, Caserta, Italy.
authors: Fausto
authors: F
authors: Ferraro
keywords: Drug therapeutic failure; glucocorticoids; neuromuscular block; rocuronium