title: Topical Niosome Gel of Zingiber cassumunar Roxb. Extract for Anti-inflammatory Activity Enhanced Skin Permeation and Stability of Compound D.
abstract: An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded thermal-accelerated decomposition of compound D in the gel (p < 0.05) but did not change the activation energy of compound D. Niosomes enhanced in vitro permeation rate of compound D from the gel. Topical applications of ZC noisome gel gave a faster change in tail flick latency than piroxicam gel and hydrocortisone cream (p < 0.05) while there were insignificant differences in anti-inflammatory activity up to 6 h using croton oil-induced ear edema model in mice (p > 0.05). Thus, encapsulation of ZC extract in niosomes enhanced chemical stability and skin permeation with comparable topical anti-inflammatory effects to steroid and NSAID.
authors: Division of Pharmaceutical Technology, Faculty of Pharmaceutical Science, Khon Kaen University, Khon Kaen, 40002, Thailand. apriprem@gmail.com.
authors: Aroonsri
authors: A
authors: Priprem
authors: Program in Pharmaceutical Chemistry and Natural Products, Faculty of Pharmaceutical Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
authors: Khwanhatai
authors: K
authors: Janpim
authors: Division of Pharmacognosy and Medicinal Chemistry, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, 44150, Thailand.
authors: Somsak
authors: S
authors: Nualkaew
authors: Division of Toxicology, Faculty of Pharmaceutical Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
authors: Pramote
authors: P
authors: Mahakunakorn
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000831:Animals, Newborn; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000378:metabolism*; D000440:Butanols / Q000378:metabolism*; D004355:Drug Stability; D004487:Edema / Q000188:drug therapy / Q000378:metabolism; D005782:Gels; D020939:Zingiber officinale; D008081:Liposomes / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009924:Organ Culture Techniques; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000378:metabolism*; D011897:Random Allocation; D012869:Skin Absorption / Q000187:drug effects* / Q000502:physiology; D013552:Swine
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000440:Butanols; D005782:Gels; D008081:Liposomes; D010936:Plant Extracts; C053776:4-(3',4'-dimethoxyphenyl)but-3-en-1-ol
keywords: Activation energy; Compound D; Niosomal gel; Topical anti-inflammatory; Zingiber cassumunar