title: Copper-catalyzed cyanation of aryl iodides with α-cyanoacetates via C-CN bond activation.
abstract: A Cu(I)-catalyzed cyanation reaction of aryl iodides with α-cyanoacetates is reported herein, which uses α-cyanoacetates as the nontoxic and easy-handling CN source through copper-mediated C-CN bond cleavage. This reaction enables access to aryl nitriles with an array of functional groups on the aromatic ring in good to excellent yields.
authors: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, Jiangsu Province, China. slzhang@jiangnan.edu.cn.
authors: Song-Lin
authors: SL
authors: Zhang
authors: Lu
authors: L
authors: Huang
mesh_terms: D000085:Acetates / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000085:Acetates; D006841:Hydrocarbons, Aromatic; D007454:Iodides; D009570:Nitriles; D003300:Copper