title: Increase of 25-hydroxyvitamin D levels after initiation of combination antiretroviral therapy.
abstract: Although vitamin D deficiency in HIV patients reported worldwide, the mechanisms and the effect of combination antiretroviral therapy (cART) on vitamin D levels are unclear. Patients were 50 male Japanese with HIV who visited Teikyo University Hospital, Tokyo, Japan. Patients were divided into those receiving cART (cART-experienced group, n = 30) and those who had not received cART (cART-naïve group, n = 20). Patients in the cART-experienced group had received treatment with cART for more than one year and those in the cART-naïve group were just about to start cART at study entry. Patients underwent measurement of serum 25-hydroxyvitamin D (25(OH)D) levels and assessment of clinical factors twice at one year intervals. At study entry, 23 (76.7%) in the cART-experienced group and 19 (95.0%) in the cART-naïve group had vitamin D insufficiency or deficiency. Mean 25(OH)D values were significantly higher in the cART-experienced group (25.2 ng/ml vs. 19.3 ng/ml, p = 0.01). However, levels of 25(OH)D at one year increased more in the cART-naïve group (-1.1 ng/ml vs. 5.0 ng/ml, p = 0.01), with mean 25(OH)D values in the cART-naïve group increasing to match those in the cART-experienced group. HIV infected patients who initiated cART showed increases in vitamin D levels in one year.
authors: Department of Infectious Diseases, Teikyo University School of Medicine, Japan. Electronic address: koga@med.teikyo-u.ac.jp.
authors: Ichiro
authors: I
authors: Koga
authors: Department of Infectious Diseases, Teikyo University School of Medicine, Japan.
authors: Kazunori
authors: K
authors: Seo
authors: Department of Infectious Diseases, Teikyo University School of Medicine, Japan.
authors: Yusuke
authors: Y
authors: Yoshino
authors: Department of Infectious Diseases, Teikyo University School of Medicine, Japan.
authors: Takatoshi
authors: T
authors: Kitazawa
authors: Department of Infectious Diseases, Teikyo University School of Medicine, Japan.
authors: Yasuo
authors: Y
authors: Ota
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000009:adverse effects; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood / Q000172:deficiency; D007564:Japan; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000209:etiology
chemical_list: D019380:Anti-HIV Agents; D006887:Hydroxycholecalciferols; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-Hydroxyvitamin D; Combination antiretroviral therapy; HIV; Protease inhibitors