title: Creation of a cerebellar diameter reference standard and its clinical application to the detection of cerebellar hypoplasia unique to trisomy 18.
abstract: OBJECTIVE
  We created a new reference standard focusing on the hemispheric anteroposterior cerebellar diameter (APCD) in addition to the transverse cerebellar diameter (TCD) and discussed whether or not the cerebellar measurement was useful for the detection of trisomy 18 (T18).
  
  
  METHODS
  In 150 normal fetuses between 14 and 36 weeks of gestational age (GA), the TCD and APCD were prospectively measured. In 26 cases with T18, the value was compared with the control.
  
  
  RESULTS
  At <22 weeks of gestation, the TCD reference standard was calculated as follows: TCD = (1.027 × GA) - 0.674 (R(2) = 0.97, P < 0.001). The reference standard of the APCD was calculated as follows: APCD = (0.682 × GA) - 3.925 (R(2) = 0.73, P < 0.001). In eight cases with T18, the TCD was below the 5th percentile value in 7/8 (88%) cases and the APCD was below the 5th percentile value in 8/8 (100%) cases. At >22 weeks of gestation, the reference standard of the TCD was calculated as follows: TCD = (1.603 × GA) - 13.216 (R(2) = 0.92, P < 0.001). The reference standard of the APCD was calculated as follows: APCD = (0.859 × GA) - 7.30 (R(2) = 0.84, P < 0.001). In 18 cases with T18, the TCD was below the 5th percentile value in 14/18 (78%) cases and the APCD was below the 5th percentile value in 18/18 (100%) cases.
  
  
  CONCLUSIONS
  APCD reference standard, divided by the gestational age of more or less than 22 weeks, might be useful to diagnose T18.
authors: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.
authors: Kei
authors: K
authors: Hayata
authors: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.
authors: Yuji
authors: Y
authors: Hiramatsu
authors: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.
authors: Hisashi
authors: H
authors: Masuyama
authors: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.
authors: Eriko
authors: E
authors: Etou
authors: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.
authors: Etsuko
authors: E
authors: Nobumoto
authors: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.
authors: Takashi
authors: T
authors: Mitsui
mesh_terms: D000328:Adult; D002531:Cerebellum / Q000002:abnormalities* / Q000473:pathology*; D002887:Chromosomes, Human, Pair 18; D002658:Developmental Disabilities / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D009421:Nervous System Malformations / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy; D011446:Prospective Studies; D012015:Reference Standards; D014314:Trisomy / Q000473:pathology*; D000073842:Trisomy 18 Syndrome
keywords: anteroposterior cerebellar diameter; cerebellar hypoplasia; prenatal diagnosis; trisomy18; ultrasonography