title: The impact of acute aerobic exercise on chitinase 3-like protein 1 and intelectin-1 expression in obesity.
abstract: Chitinase 3-like 1 (CHI3L1) and intelectin 1 (ITLN-1) recognize microbial N-acetylglucosamine polymer and galactofuranosyl carbohydrates, respectively. Both lectins are highly abundant in plasma and seem to play pro- and anti-inflammatory roles, respectively, in obesity and inflammatory-related illnesses. The aim of this study was to examine whether plasma levels of these lectins in obese subjects are useful for monitoring inflammatory conditions immediately influenced by acute aerobic exercise. Plasma interleukin-6, a pro-inflammatory cytokine, was also examined. Twenty-two (11 obese and 11 normal-weight) healthy subjects, ages 18-30 years, were recruited to perform a 30 min bout of acute aerobic exercise at 75% VO2max. We confirmed higher baseline levels of plasma CHI3L1, but lower ITLN-1, in obese subjects than in normal-weight subjects. The baseline levels of CHI3L1 were negatively correlated with cardiorespiratory fitness (relative VO2max). However, when controlled for BMI, the relationship between baseline level of CHI3L1 and relative VO2max was no longer observed. While acute aerobic exercise elicited an elevation in these parameters, we found a lower ITLN-1 response in obese subjects compared to normal-weight subjects. Our study clearly indicates that acute aerobic exercise elicits a pro-inflammatory response (e.g. CHI3L1) with a lower anti-inflammatory effect (e.g. ITLN-1) in obese individuals. Furthermore, these lectins could be predictors of outcome of exercise interventions in obesity-associated inflammation.
authors: Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA chuang5@fau.edu.
authors: Chun-Jung
authors: CJ
authors: Huang
authors: Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA.
authors: Aaron L
authors: AL
authors: Slusher
authors: Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.
authors: Michael
authors: M
authors: Whitehurst
authors: Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.
authors: Marie
authors: M
authors: Wells
authors: Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.
authors: Arun
authors: A
authors: Maharaj
authors: Department of Biomedical Science, College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USA.
authors: Yoshimi
authors: Y
authors: Shibata
mesh_terms: D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D000071451:Chitinase-3-Like Protein 1; D016207:Cytokines / Q000097:blood*; D015444:Exercise; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D064368:Healthy Volunteers; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D037102:Lectins / Q000097:blood*; D008297:Male; D009765:Obesity / Q000473:pathology* / Q000628:therapy*; D055815:Young Adult
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D016207:Cytokines; D058851:GPI-Linked Proteins; C508600:IL6 protein, human; C432397:ITLN1 protein, human; D015850:Interleukin-6; D037102:Lectins
keywords: Obesity; chitinase-3 protein 1; exercise; inflammation; intelectin-1; interleukin-6