title: RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer.
abstract: The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.
authors: Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
authors: Thatchawan
authors: T
authors: Thanasupawat
authors: Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
authors: Aleksandra
authors: A
authors: Glogowska
authors: Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
authors: Maxwell
authors: M
authors: Burg
authors: Department of Physiology, Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
authors: G William
authors: GW
authors: Wong
authors: Clinics of General, Visceral and Vascular Surgery, Martin Luther University , Halle/Salle , Germany.
authors: Cuong
authors: C
authors: Hoang-Vu
authors: Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada ; Department of Obstetrics, Gynecology and Reproductive Medicine, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
authors: Sabine
authors: S
authors: Hombach-Klonisch
authors: Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada ; Department of Surgery, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada ; Department of Medical Microbiology and Infectious Diseases, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
authors: Thomas
authors: T
authors: Klonisch
keywords: C1q/TNF-related proteins; CTRP8; RXFP1; brain tumor; cancer