title: [Advances of Researches on the Role of Histone Modification in Hematological Neoplasms].
abstract: As a crucial part of epigenetic regulation, the histone modification catalyzed by histone modification enzymes can alter the chromatin structure and modulate the gene expression. The role of histone modification in disease pathogenesis, especially in tumorigenesis, has become a research hotspot. The deregulation of histone modification, such as the overexpression and gain-of-function mutations of histone methyltransferase EZH2, the inactive mutations of histone methyltransferase MLL2, histone acetyltransferase CREBBP and EP300 are crucial for the development of hematological neoplasms. Some of Epi-drugs such as HDAC inhibitors, EZH2 inhibitors, are already clinically used, some are still in basic research stage, which are important field of new drug development for hematological neoplasms. In this review, the researches advances of basic medical sciences and clinical applications of aberrant histone modifications in hematological neoplasms are summarized.
authors: Department of Pathology, College of Basic Medicine, DaLi University, Dali 671000, Yunnan Province, China.
authors: Fang
authors: F
authors: Sun
authors: Department of Pathology, Affiliated Hospital of Dali University, Dali 671000, Yunnan Province, China.
authors: Yun
authors: Y
authors: Pan
authors: Department of Pathology, College of Basic Medicine, DaLi University, Dali 671000, Yunnan Province, China. E-mail: bigbigsmile04@gmail.com.
authors: Yan
authors: Y
authors: Li
mesh_terms: D002471:Cell Transformation, Neoplastic; D044127:Epigenesis, Genetic; D019337:Hematologic Neoplasms; D056572:Histone Deacetylase Inhibitors; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D006657:Histones; D006801:Humans
chemical_list: D056572:Histone Deacetylase Inhibitors; D006657:Histones; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase