title: Shear Wave Elastography in the Diagnosis of Thyroid Nodules with Coexistent Chronic Autoimmune Hashimoto's Thyroiditis.
abstract: OBJECTIVE
  To evaluate the diagnostic performance of shear wave elastography (SWE) in the differentiation of malignant and benign thyroid nodules with coexistent Hashimoto's thyroiditis (HT).
  
  
  METHODS
  Case series with chart review.
  
  
  METHODS
  Tertiary general hospital.
  
  
  METHODS
  From September 2012 to January 2014, conventional ultrasound and SWE were performed on 243 patients with 286 thyroid nodules with histologic results. The HT group consisted of 93 patients with 117 nodules. The non-HT group consisted of 140 patients with 169 nodules.
  
  
  RESULTS
  In the benign and malignant nodules, there were no significant differences of the mean, minimum, or maximum SWE values between HT and non-HT groups (P = .158-.945). However, SWE values of extranodular tissue were significantly higher in the HT group (P = .000-.011). In the HT group, the maximum SWE value showed the highest area under the receiver operating characteristic curve (0.817; 95% confidence interval, .735-.900), and there were no significant differences when compared with other SWE parameters (P = .669-.848). In the multivariate analysis, hypoechogenicity (odds ratio = 9.855, P = .002), microcalcification (odds ratio = 3.977, P = .046), and maximum SWE value (odds ratio = 40.712, P < .001) were independent predictors of thyroid malignancy.
  
  
  CONCLUSIONS
  SWE could be performed to obtain a differential diagnosis between malignant and benign thyroid nodules, including nodules with coexistent HT. Although all the SWE parameters within a 2-mm region of interest that was placed on the stiffest region could be applied, we suggest that the maximum value of nodules harbored within a Hashimoto's gland be used.
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, Guangzhou, China.
authors: Baoxian
authors: B
authors: Liu
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, Guangzhou, China.
authors: Jinyu
authors: J
authors: Liang
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, Guangzhou, China.
authors: Luyao
authors: L
authors: Zhou
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, Guangzhou, China.
authors: Ying
authors: Y
authors: Lu
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, Guangzhou, China.
authors: Yanling
authors: Y
authors: Zheng
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, Guangzhou, China.
authors: Wenshuo
authors: W
authors: Tian
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, Guangzhou, China xxy1992@live.cn.
authors: Xiaoyan
authors: X
authors: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques / Q000379:methods; D005260:Female; D050031:Hashimoto Disease / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016606:Thyroid Nodule / Q000150:complications / Q000175:diagnosis*; D055815:Young Adult
keywords: Hashimoto’s thyroiditis; Thyroid nodule; malignancy; shear wave elastography