title: Prevalence of periodontitis in individuals with human leukocyte antigens (HLA) A9, B15, A2, and B5.
abstract: OBJECTIVE
  Human leukocyte antigens (HLA) have been associated with periodontitis. Previous studies revealed HLA-A9 and HLA-B15 as potential susceptibility factors, while HLA-A2 and HLA-B5 might have protective effects. The aim of the study was to verify these associations in a group of HLA-typed blood donors with previously unknown periodontal status.
  
  
  METHODS
  In four German centers, 140 blood donors with known HLA class I status were enrolled and allocated to the following five groups: HLA-A9 (N = 24), HLA-B15 (N = 20), HLA-A2 (N = 30), HLA-B5 (N = 26), and controls (N = 40). Periodontal examination included the measurement of probing depths (PDs), clinical attachment level (CAL), bleeding on probing (BOP), and community periodontal index of treatment needs (CPITN).
  
  
  RESULTS
  Carriers with HLA-A9 and HLA-B15 had higher values of mean PD (P < 0.0001), CAL (P < 0.0001), and BOP (P < 0.002) as well as sites with PD and CAL with ≥4 and ≥6 mm (P < 0.0003), respectively, than controls. Multiple regression analyses revealed HLA-A9, HLA-B15, and smoking as risk indicators for moderate to severe (CPITN 3-4; odds ratio (OR): 66.7, 15.3, and 5.1) and severe (CPITN 4; OR: 6.6, 7.4, and 3.8) periodontitis. HLA-A2 and HLA-B5 did not show any relevant associations.
  
  
  CONCLUSIONS
  The present data support a role of HLA-A9 and HLA-B15 as susceptibility factors for periodontitis, whereas HLA-A2 and HLA-B5 could not be confirmed as resistance factors.
  
  
  CONCLUSIONS
  Both HLA antigens A9 and B15 are potential candidates for periodontal risk assessment.
authors: Department of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital (RWTH) Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. JStein@ukaachen.de.
authors: Jamal M
authors: JM
authors: Stein
authors: Institute of Physiology, University of the Saarland, Kirrberger Straße 100, 66424, Homburg/Saar, Germany.
authors: Helmut K G
authors: HK
authors: Machulla
authors: Section of Experimental Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstraße 17, 53111, Bonn, Germany.
authors: James
authors: J
authors: Deschner
authors: Department of Periodontology, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
authors: Stefan
authors: S
authors: Fickl
authors: Department of Periodontology, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
authors: Yvonne
authors: Y
authors: Jockel-Schneider
authors: Department of Medical Statistics, University Hospital (RWTH) Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
authors: Miriam
authors: M
authors: Tamm
authors: Department of Operative Dentistry and Periodontology, Martin Luther University Halle-Wittenberg, Große Steinstraße 19, 06108, Halle (Saale), Germany.
authors: Susanne
authors: S
authors: Schulz
authors: Department of Operative Dentistry and Periodontology, Martin Luther University Halle-Wittenberg, Große Steinstraße 19, 06108, Halle (Saale), Germany.
authors: Stefan
authors: S
authors: Reichert
mesh_terms: D006680:HLA Antigens; D006801:Humans; D010512:Periodontal Index; D010518:Periodontitis / Q000453:epidemiology* / Q000276:immunology; D015995:Prevalence
chemical_list: D006680:HLA Antigens
keywords: HLA; Major histocompatibility complex; Periodontitis; Risk factors