title: One new cycloartane triterpene glycoside from Beesia calthaefolia.
abstract: One new cycloartane triterpene glycoside (1) was isolated from the whole plant of Beesia calthaefolia. Its structure was elucidated on the basis of extensive spectroscopic data analysis. Its inhibitory effect was measured by the classical pathway of the complement system, and compared with those of known related cycloartane glycosides 2 and 3, previously isolated by us from the same plant. Compounds 1 and 2 exhibited inhibitory activity of complement system with IC50 of 395.3 and 214 μM, respectively. The results suggested that OH at C-12, C-18 and C-15 along with the polarity could affect the inhibitory activity.
authors: a Department of Clinical Pharmacology , General Hospital of PLA , Beijing 100853 , P.R. China.
authors: Jin-Yuan
authors: JY
authors: Zhao
authors: a Department of Clinical Pharmacology , General Hospital of PLA , Beijing 100853 , P.R. China.
authors: Li-Hua
authors: LH
authors: Mu
authors: a Department of Clinical Pharmacology , General Hospital of PLA , Beijing 100853 , P.R. China.
authors: Xian-zhe
authors: XZ
authors: Dong
authors: a Department of Clinical Pharmacology , General Hospital of PLA , Beijing 100853 , P.R. China.
authors: Yuan
authors: Y
authors: Hu
authors: a Department of Clinical Pharmacology , General Hospital of PLA , Beijing 100853 , P.R. China.
authors: Ping
authors: P
authors: Liu
mesh_terms: D000818:Animals; D003169:Complement Inactivator Proteins / Q000737:chemistry / Q000494:pharmacology; D003171:Complement Pathway, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004912:Erythrocytes / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029626:Ranunculaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: C000609647:(20S*, 24S*)-16beta, 24;20,24-diepoxy-9,19-cycloanostane-3beta,12beta,25-triol-3-O-(beta-D-glucopyranosyl-(1-3))-beta-D-xylopyranoside; D003169:Complement Inactivator Proteins; D006027:Glycosides; D014315:Triterpenes; C085352:cycloartane
keywords: Beesia calthaefolia; classical pathway; complement system; cycloartane triterpene glycoside