title: Metabolic Remodeling in Times of Stress: Who Shoots Faster than His Shadow?
abstract: A sudden increase in pentose phosphate pathway (PPP) activity, the fastest known cellular response to oxidative stress, protects cells through timely generation of NADPH. Originally discovered in budding yeast, Kuehne and colleagues demonstrate the conservation of this mechanism in human cells and reveal its importance for skin cells exposed to UV light.
authors: Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
authors: Tobias P
authors: TP
authors: Dick
authors: Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK; The Francis Crick Institute, Mill Hill Laboratory, Mill Hill, London, NW71AA, UK. Electronic address: mr559@cam.ac.uk.
authors: Markus
authors: M
authors: Ralser
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D015603:Keratinocytes / Q000187:drug effects* / Q000528:radiation effects*; D008565:Membrane Proteins / Q000378:metabolism*; D010427:Pentose Phosphate Pathway / Q000187:drug effects* / Q000528:radiation effects*; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; D013963:Thyroid Hormones; D006861:Hydrogen Peroxide