title: Jump in the fire--heat shock proteins and their impact on ovarian cancer therapy.
abstract: Ovarian cancer (OC) is a major problem in gynecological oncology. Options for diagnosis and treatment of advanced stages and thus for patient prognosis have not been improved substantially over the past decades. Heat shock proteins (HSP) are characterized as stress-induced molecular chaperones performing cell survival factor functions. In cancer cells, various crucial and clinically important cell responses are vitally influenced and modulated by HSPs, e.g., cell growth and treatment resistance. Despite the limited knowledge on HSPs in OC progression, their roles as biomarkers, prognostic factors and their drug target properties appears promising for future clinical applications and therapeutic approaches.
authors: Department of Urology, University Medicine Greifswald, Greifswald, Germany. Electronic address: matthias.stope@uni-greifswald.de.
authors: M B
authors: MB
authors: Stope
authors: Department of Gynaecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany.
authors: D
authors: D
authors: Koensgen
authors: Department of Urology, University Medicine Greifswald, Greifswald, Germany.
authors: M
authors: M
authors: Burchardt
authors: Department of Gynaecology and Obstetrics, Innsbruck Medical University, Innsbruck, Austria.
authors: N
authors: N
authors: Concin
authors: Department of Gynaecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany.
authors: M
authors: M
authors: Zygmunt
authors: Department of Gynaecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany.
authors: A
authors: A
authors: Mustea
mesh_terms: D018450:Disease Progression; D005260:Female; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D006360:Heat-Shock Proteins
keywords: Chemoresistance; Diagnosis; Drug target; Heat shock protein; Ovarian cancer