title: Research on induced pluripotent stem cells and the application in ocular tissues.
abstract: Induced pluripotent stem cells (iPSCs) were firstly induced from mouse fibroblasts since 2006, and then the research on iPSCs had made great progress in the following years. iPSCs were established from different somatic cells through DNA, RNA, protein or small molecule pathways and transduction vehicles. With continuous improvement of technology on reprogramming, the induction of iPSCs became more secure and effective, and showed enormous promise for clinical applications. We reviewed different reprogramming of somatic cells, four kinds of pathways of reprogramming and three types of transduction vehicles, and discuss the research of iPSCs in ophthalmology and the prospect of iPSCs applications.
authors: Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou 510632, Guangdong Province, China.
authors: Xiao-Ling
authors: XL
authors: Guo
authors: Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou 510632, Guangdong Province, China ; Eye Institute, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Department of Ophthalmology, the First Clinical Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China.
authors: Jian-Su
authors: JS
authors: Chen
keywords: induced pluripotent stem cells; ocular tissues; reprogramming