title: Synthesis of a reactive oxygen species responsive heterobifunctional thioketal linker.
abstract: A new heterobifunctional reactive oxygen species (ROS) responsive thioketal linker and its synthesis are described. This linker allows for developing new ROS-responsive agents with two distinct functionalities using universal bioconjugation methods. The reaction kinetics of the thioketal cleavage in the presence of ROS is also described.
authors: Molecular Imaging Laboratory, Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
authors: Xiaoxi
authors: X
authors: Ling
authors: Molecular Imaging Laboratory, Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
authors: Shaojuan
authors: S
authors: Zhang
authors: Molecular Imaging Laboratory, Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
authors: Pin
authors: P
authors: Shao
authors: Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
authors: Pengcheng
authors: P
authors: Wang
authors: Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
authors: Xiaochao
authors: X
authors: Ma
authors: Molecular Imaging Laboratory, Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
authors: Mingfeng
authors: M
authors: Bai
keywords: Thioketal; esterase; protecting group; reaction kinetics; reactive oxygen species; stimuli responsive linker