title: Adverse events of EUS-guided FNA of pancreatic cystic and solid lesions by using the lexicon proposed in an ASGE workshop: a prospective and comparative study.
abstract: OBJECTIVE
  Pancreatic cysts and solid lesions are routinely examined by EUS-guided FNA (EUS-FNA). The aim of this study was to compare the incidence of adverse events (AEs) of this procedure by using the lexicon recommended by the American Society for Gastrointestinal Endoscopy (ASGE).
  
  
  METHODS
  This was a prospective and comparative study of patients who underwent EUS-FNA in which a 22-gauge needle was used. In the pancreatic cystic lesions group (group I), complete fluid evacuation in a single needle pass was attempted, and ciprofloxacin was given during the procedure and for 3 days after. In the pancreatic solid lesions group (group II), the number of passes was determined by the on-site evaluation of the sample. AEs were defined and graded according to the lexicon recommended by the ASGE. Patients were followed for 48 hours, 1 week, and 1 month after the procedure.
  
  
  RESULTS
  A total of 146 patients were included, 73 in group I and 73 in group II. Potential factors influencing the incidence of AEs (ie, access route for FNA) were similar in both groups. AEs occurred in 5 of 146 patients (3.4%; 95% confidence interval [CI], 1.3%-8%): 4 in group I (5.5%; 95% CI, 1.7%-13.7%) and 1 in group II (1.4%; 95% CI, -0.5% to 8.1%) (P = .03). Severity was mild in 1 of 5 patients (20%) and moderate in 3 of 5 patients (60%). One patient with a solid mass in the head of the pancreas had a duodenal perforation after EUS and died after surgery. All other AEs occurred in the first 48 hours and resolved with medical therapy. There were 3 incidents of transient hypoxia and self-limited abdominal pain in 1 and 2 patients, respectively. No patients were lost to follow-up.
  
  
  CONCLUSIONS
  EUS-FNA of pancreatic cysts has an AEs rate similar to that of solid pancreatic masses, which is small enough to consider this procedure a safe and effective method for managing patients with both types of lesions. AEs occurred early after EUS-FNA, and patients should be closely followed during the first 2 days after the procedure.
authors: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
authors: Antonio
authors: A
authors: Rodríguez-D'Jesús
authors: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
authors: Gloria
authors: G
authors: Fernández-Esparrach
authors: Hospital Universitario Araba, Vitoria-Gasteiz, Spain.
authors: Carlos
authors: C
authors: Marra-Lopez
authors: Hospital Universitario Araba, Vitoria-Gasteiz, Spain.
authors: Aitor
authors: A
authors: Orive-Calzada
authors: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
authors: Oriol
authors: O
authors: Sendino
authors: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
authors: Isis K
authors: IK
authors: Araujo
authors: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
authors: Cristina
authors: C
authors: Rodríguez de Miguel
authors: Instituto Ramón y Cajal de Investigación, Madrid, Spain.
authors: Enrique
authors: E
authors: Vázquez-Sequeiros
authors: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
authors: Henry
authors: H
authors: Córdova
authors: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
authors: Cristina
authors: C
authors: Sánchez-Montes
authors: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
authors: Begoña
authors: B
authors: González-Suárez
authors: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
authors: Angels
authors: A
authors: Ginès
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000368:Aged; D004378:Duodenal Diseases / Q000209:etiology*; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000009:adverse effects*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D007416:Intestinal Perforation / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010181:Pancreatic Cyst / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D011446:Prospective Studies; D012955:Societies, Medical; D009626:Terminology as Topic