title: Palmar and plantar lichen planus: a case report and review of the literature.
abstract: Palmoplantar lichen planus is an uncommon dermatosis. We present a case of 38-year-old Caucasian male with a history of pruritic, scaly lesions on the right plantar foot. Physical examination revealed whitish plaques and numerous spiny hyperkeratotic papules and focal scaling. A biopsy demonstrated orthohyperkeratosis and acanthosis of the epidermis. Immunohistochemical staining revealed positivity within the epidermis and/or lichenoid infiltrate with CD3, CD8, CD45, CD68, myeloid histiod antigen, BCL2, p27, p53, HLA-DPDQDR, metallothionein and tissue inhibitor of metalloproteinases 1. The diagnosis of PPLP was thus confirmed; this case illustrates that PPLP should be considered in the differential diagnosis of uncommon foot dermatoses with a significant junctional inflammatory component.
authors: Georgia Dermatopathology Associates, Atlanta, US.
authors: Ana Maria
authors: AM
authors: Abreu Velez
authors: Georgia Dermatopathology Associates, Atlanta, US.
authors: Michael S
authors: MS
authors: Howard
authors: Dermatology and Skin Surgery Center, Stockbridge, US.
authors: Neville
authors: N
authors: Pereyo
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D004817:Epidermis / Q000473:pathology; D005533:Foot Dermatoses / Q000473:pathology*; D006229:Hand Dermatoses / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008010:Lichen Planus / Q000473:pathology*; D008297:Male