title: The Prognostic Significance of Her2-Neu Over expression in Gastric Carcinomas.
abstract: BACKGROUND
  Her2/neu is one of the epidermal growth factor receptors families and seems to have prognostic significance of some solid tumors. The objective of this study is to evaluate the possibility of Her2 expression in gastric cancers and the possible relationship of Her2 with tumor's clinicopathologic parameters and also its prognostic role.
  
  
  METHODS
  This study was performed on 100 cases of gastric carcinoma with stage I b to III (according to TNM staging). Survival, recurrence date of patients, grade and lymph nodes involvement were assessed. Her2/neu expression was determined by immunohistochemical method on received sample blocks. Survival of patients with or without Her2-neu expression were evaluated by Kaplan- Meier method and compared with the log-rank test followed by multivariate analysis using Cox regression.
  
  
  RESULTS
  Seven cases were 3+ membranous Her2 reactivity, 5 cases were 2+ and13 cases were 1+; also 75% of cases demonstrated no reactivity. Regardingrelationship between tumor grade and membranous Her2 , all patients with poorly differentiated tumors were Her2 negative but patients with moderate and well differentiated tumor had 18.1% and 19.6% Her2 reactivity respectively; there were no significant difference between groups statistically(P>0.05). Median overall survival was 27.25 and 46 months in Her2 negative and her2 positive cases respectively; there were no significant difference between groups statistically as well (P>0.05).
  
  
  CONCLUSIONS
  Her2 reactivity has not relationship with tumor grade and lymph node involvement as well as tumor stage. From the other point of view no significant correlation is found between Her2 expression and disease free survival or overall survival of gastric cancer patients.
authors: Dept. of Radiation Oncology, Aiatollah Khoansari Hospital, Arak University of Medical Sciences, Arak, Iran.
authors: J
authors: J
authors: Ansari
authors: Dept. of Pathology, Amiralmoamenin Hospital, Arak University of Medical Sciences, Arak, Iran.
authors: A
authors: A
authors: Chehrei
authors: Dept. of Surgery, Valiasr Hospital, Arak University of Medical Sciences, Arak, Iran.
authors: M
authors: M
authors: Amini
authors: Dept. of Surgery, Valiasr Hospital, Arak University of Medical Sciences, Arak, Iran.
authors: S H
authors: SH
authors: Alizade
authors: Dept. of Pathology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: M H
authors: MH
authors: Sanei
keywords: Adenocarcinoma; Gastric cancer; Her2 neu peptide; Survival analysis