title: Current advances in biosampling for therapeutic drug monitoring of psychiatric CNS drugs.
abstract: Many CNS drugs are effective for the treatment of psychiatric disorders. Psychotropic drugs work differently, thus clinical outcomes for many patients may be insufficient. For this reason it could be useful the measurement of drug levels for clinical decision-making. Analytical goals in therapeutic drug monitoring (TDM) should be established by selecting the appropriate biological matrix. The aim of this review is to highlight the usefulness of TDM for antiepileptics, antidepressants and antipsychotics, with a focus on current advances in biosampling. The literature on TDM was reviewed up to March 2015. An overview on the use of alternative biological matrices is provided to address the current issues and advances in the field of biosampling for psychiatric CNS drug TDM.
authors: Laboratory of Pharmaco-Toxicological Analysis, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
authors: Laura
authors: L
authors: Mercolini
authors: Laboratory of Pharmaco-Toxicological Analysis, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
authors: Maria Addolorata
authors: MA
authors: Saracino
authors: Laboratory of Pharmaco-Toxicological Analysis, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
authors: Michele
authors: M
authors: Protti
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D011619:Psychotropic Drugs / Q000627:therapeutic use*
chemical_list: D014150:Antipsychotic Agents; D011619:Psychotropic Drugs