title: Evaluating Autologous Lipofilling for Parry-Romberg Syndrome-Associated Defects: A Systematic Literature Review and Case Report.
abstract: Parry-Romberg syndrome (PRS) is a rare craniofacial disease that causes progressive hemifacial atrophy of the soft tissue before spontaneously entering remission. Autologous fat grafting may provide a less invasive alternative, producing aesthetically pleasing results while avoiding the need for traditional microsurgical free flap coverage.
  
  
  
  A systematic review of the literature was conducted. Inclusion and exclusion criteria were applied. The case report highlights the technique using two-dimensional and three-dimensional photography.
  
  
  
  Our review yielded 31 articles in addition to our case describing 147 cases of lipofilling to correct PRS soft-tissue defects. Patients underwent an average of 2.2 procedures, receiving on average 95 mL of grafted fat. Disease severity was classified into mild (41%), moderate (42%), and severe (17%) in the identified patients. Increasing disease severity correlated with an increasing number of procedures and fat-grafting volumes to achieve adequate aesthetic outcomes (mean, 1.5 and 38 mL; 2.3 and 81 mL; 3.7 and 129 mL, respectively). Reported benefits over flap-based reconstructions included reductions in cost (40%), operative time (50%), donor-site morbidity (52%), and rate of complications (33%). Aesthetic benefits cited included improved skin quality (65%), more natural contours (1%), and more natural facial expressions (10%).
  
  
  
  Fat grafting for correction of PRS-associated soft-tissue defects is receiving heightened acceptance for its ability to restore natural facial contours. While additional fat-grafting procedures may be required with increased disease severity, autologous fat grafting may be a beneficial option as a sole modality to correct PRS-associated soft-tissue atrophy.
authors: Katherine A
authors: KA
authors: Rodby
authors: Yvonne E
authors: YE
authors: Kaptein
authors: James
authors: J
authors: Roring
authors: Ryan J
authors: RJ
authors: Jacobs
authors: Vicky
authors: V
authors: Kang
authors: Karina P
authors: KP
authors: Quinn
authors: Anuja K
authors: AK
authors: Antony
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000293:Adolescent; D005150:Facial Hemiatrophy / Q000601:surgery*; D058752:Free Tissue Flaps; D006801:Humans; D008297:Male; D019651:Plastic Surgery Procedures
keywords: Parry-Romberg; fat grafting; hemifacial atrophy; lipofilling; systematic review