title: Pre-treatment mean platelet volume associates with worse clinicopathologic features and prognosis of patients with invasive breast cancer.
abstract: BACKGROUND
  Mean platelet volume (MPV) is one of the four platelet parameters (platelet count, MPV, platelet distribution width and plateletcrit), which indicates the activation of platelet. We aim to investigate the associations between pre-treatment MPV levels and clinical hematology parameters, pathology parameters and prognosis of patients with invasive breast cancer (IBC).
  
  
  METHODS
  Medical records of 340 breast tumor patients (170 IBC vs. 170 breast benign tumor) were retrospectively reviewed. Patients in two groups were matched for age, body mass index, smoking status and complications. To analyze: differences in pre-treatment MPV levels between IBC group and breast benign tumor group; differences between pre- and postoperative MPV levels in IBC patients; correlations between pre-treatment MPV and clinical hematology parameters, clinicopathologic parameters and prognosis in IBC patients.
  
  
  RESULTS
  As we analyzed, pre-treatment MPV levels of IBC patients were significantly higher than the controls (8.65 ± 0.98 vs 8.34 ± 0.78, P = 0.002), and preoperative MPV levels were significantly higher than the postoperative in IBC patients (8.65 ± 0.98 vs 8.44 ± 0.91, P = 0.042). In IBC group, pre-treatment MPV level associated, significantly, with clinical hematology parameters (platelet, fibrinogen, albumin, fasting blood glucose, P = 0.003, 0.042, 0.032, 0.046, respectively) and with clinicopathological parameters (distant metastasis, primary tumor size, tumor node metastasis stages, P = 0.039, 0.002, 0.001, respectively). Furthermore, univariate and multivariate survival analysis demonstrated that MPV was significant prognostic factor (P = 0.035, HR 1.86, 95 % confidence interval 1.06-3.25).
  
  
  CONCLUSIONS
  High pre-treatment MPV level in IBC patients was a potential predictive factor and significant independent prognostic factor.
authors: Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, No. 2, The Fifth Section of Renmin Street, Guta, Jinzhou, 121000, Liaoning, China.
authors: Meiling
authors: M
authors: Gu
authors: Department of Oncology Tumour Angiogenesis and Microenvironment Laboratory, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China.
authors: Zhenhua
authors: Z
authors: Zhai
authors: Institute of Biological Anthropology Research, Liaoning Medical University, Jinzhou, 121000, Liaoning, China.
authors: Li
authors: L
authors: Huang
authors: Department of Immunology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China.
authors: Wenjiao
authors: W
authors: Zheng
authors: Department of Breast Surgeon, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China.
authors: Yichao
authors: Y
authors: Zhou
authors: Department of Laboratory, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China.
authors: Ruiqi
authors: R
authors: Zhu
authors: Department of Pathology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China.
authors: Feifei
authors: F
authors: Shen
authors: Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, No. 2, The Fifth Section of Renmin Street, Guta, Jinzhou, 121000, Liaoning, China. yuancaijun112@sina.com.
authors: Caijun
authors: C
authors: Yuan
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D059186:Chemoradiotherapy, Adjuvant; D005260:Female; D006801:Humans; D063847:Mean Platelet Volume; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: Invasive breast cancer; Mean platelet volume; Predictive factor; Prognostic factor