title: Lipoprotein lipase gene Hind III polymorphism was associated with hemorrhagic stroke.
abstract: OBJECTIVE
  To investigate the relevance between lipoprotein lipase (LPL) Hind III gene polymorphism and cerebral hemorrhage.
  
  
  METHODS
  A case-control study was performed utilizing PCR-RFLP method and sequencing of amplified products to detect LPL Hind III gene polymorphism in 350 cases of hemorrhagic stroke (HS group) and 350 healthy subjects (control group). Blood lipids and glucose levels were also recorded for each attendant.
  
  
  RESULTS
  In HS group, T and G allele frequencies were 90.8% and 9.2%, respectively; while those in the control group were 82.3% and 17.7%. In HS group, detection rate of the G allele frequency and GG genotype were significantly lower than those in the control group. In addition, TG, LDL-C, fasting blood glucose , systolic blood pressure , diastolic blood pressure were significantly higher in HS group (P<0.05, P<0.01). Compared with TG+GG genotype, TT genotype population show significantly higher triglycerides concentration (P<0.05). With adjustment for hypertension, high blood sugar, and age -related factors, multivariate logistic regression analysis showed that LPL Hind III G allele could be a protective factor (OR = 0.392, 95% CI: 0.191~0.805, P = 0.011).
  
  
  CONCLUSIONS
  LPL Hind III gene polymorphism was relevant to hemorrhagic stroke. LPL Hind III G mutant allele could be a protective factor in the pathogenesis of cerebral hemorrhage.
authors: Department of Neurosurgery, Qilu Hospital, Shandong University Jinan 250012, P. R. China.
authors: Wen-Sheng
authors: WS
authors: Zhang
authors: Department of Neurosurgery, Qilu Hospital, Shandong University Jinan 250012, P. R. China.
authors: Wen-Hua
authors: WH
authors: Zhang
authors: Department of Medical Genetics, Shandong University School of Medicine Jinan 250012, P. R. China.
authors: Qi-Ji
authors: QJ
authors: Liu
keywords: Cerebral hemorrhage; gene frequencies; genotype; lipoprotein lipase; polymerase chain reaction; risk factors