title: α-Arylation of Saturated Azacycles and N-Methylamines via Palladium(II)-Catalyzed C(sp(3))-H Coupling.
abstract: Pd(II)-catalyzed α-C(sp(3))-H arylation of pyrrolidines, piperidines, azepanes, and N-methylamines with arylboronic acids has been developed for the first time. This transformation is applicable to wide arrays of pyrrolidines and boronic acids, including heteroaromatic boronic acids. A diastereoselective one-pot heterodiarylation of pyrrolidines has also been achieved.
authors: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Jillian E
authors: JE
authors: Spangler
authors: Medicinal Chemistry, Eisai Product Creation Systems, Eisai Co., Ltd. , 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 300-2635, Japan.
authors: Yoshihisa
authors: Y
authors: Kobayashi
authors: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Pritha
authors: P
authors: Verma
authors: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Dong-Hui
authors: DH
authors: Wang
authors: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Jin-Quan
authors: JQ
authors: Yu
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D008744:Methylamines / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D001897:Boronic Acids; D008744:Methylamines; D010165:Palladium; D002244:Carbon; D006859:Hydrogen