title: Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis.
abstract: BACKGROUND
  Apurinic/apyrimidinic endonuclease-1 (APE1) is a rate-limiting enzyme in DNA base excision repair and has been implicated in carcinogenesis. In this study, we summarize available data to examine the susceptibility of APE1 gene Asp148Glu variant to digestive cancer via a meta-analysis.
  
  
  METHODS
  Study selection and data abstraction were conducted independently by 2 authors. Random-effects model was utilized to pool effect estimates. Heterogeneity and publication bias were addressed.
  
  
  RESULTS
  Sixteen articles involving 4916 digestive cancer patients and 7748 controls were qualified for this meta-analysis. Overall association showed an indicative association between Asp148Glu variant and digestive cancer under allelic (odds ratio or OR=1.11; 95% confidence interval or CI: 0.99-1.25; P=0.074) and dominant (OR=1.18; 95% CI: 1.00-1.40; P=0.056) models, with strong evidence of heterogeneity. Deviation from Hardy-Weinberg equilibrium was an obvious source of heterogeneity. In subgroup analyses by cancer sites, this variant was significantly associated with the increased risk for hepatocellular cancer under allelic (OR=1.50; 95% CI: 1.25-1.80; P<0.001) and homozygous genotypic (OR=1.55; 95% CI: 1.02-2.29; P=0.028) models. There were low probabilities of publication bias for the above comparisons.
  
  
  CONCLUSIONS
  The results of this meta-analysis collectively suggest that APE1 gene Asp148Glu variant is not a risk-conferring factor for digestive cancer. Further large and well-designed studies are required.
authors: Department of Gastric and Intestine, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China (mainland).
authors: He
authors: H
authors: Li
authors: Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China (mainland).
authors: Jing
authors: J
authors: Zou
authors: Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, China (mainland).
authors: Jia
authors: J
authors: Mi
authors: Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, China (mainland).
authors: Xiaodan
authors: X
authors: Wei
authors: Institute of Anatomy, Binzhou Medical University, Yantai, Shandong, China (mainland).
authors: Dongmei
authors: D
authors: Zhao
authors: Institute of Pharmacology, Binzhou Medical University, Yantai, Shandong, China (mainland).
authors: Shuping
authors: S
authors: Zhang
authors: Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, China (mainland).
authors: Geng
authors: G
authors: Tian
mesh_terms: D001224:Aspartic Acid / Q000235:genetics*; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics*; D004067:Digestive System Neoplasms / Q000235:genetics*; D018740:Genetic Heterogeneity; D018698:Glutamic Acid / Q000235:genetics*; D006801:Humans
chemical_list: D001224:Aspartic Acid; D018698:Glutamic Acid; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase