title: Metabolic Myoglobinuria.
abstract: One large group of hereditary myopathies characterized by recurrent myoglobinuria, almost invariably triggered by exercise, comprises metabolic disorders of two main fuels, glycogen and long-chain fatty acids, or mitochondrial diseases of the respiratory chain. Differential diagnosis is required to distinguish the three conditions, although all cause a crisis of muscle energy. Muscle biopsy may be useful when performed well after the episode of rhabdomyolysis. Molecular genetics is increasingly the diagnostic test of choice to discover the underlying genetic basis.
authors: Department of Neurology, Columbia University, New York, NY, USA, emanuelebarca@hotmail.com.
authors: Emanuele
authors: E
authors: Barca
authors: Valentina
authors: V
authors: Emmanuele
authors: Salvatore Billi
authors: SB
authors: DiMauro
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009135:Muscular Diseases / Q000378:metabolism; D009212:Myoglobinuria / Q000150:complications / Q000378:metabolism*; D006435:Renal Dialysis
chemical_list: D000255:Adenosine Triphosphate; D006003:Glycogen