title: Cell Surface Engineering for Regulation of Immune Reactions in Cell Therapy.
abstract: Transplantation of the pancreatic islets of Langerhans (islets) is a promising cell therapy for treating insulin-dependent type 1 diabetes mellitus. Islet transplantation is a minimally-invasive technique involving relatively simple surgery. However, after intraportal transplantation, the transplanted islets are attacked by the recipient's immune system, because they activate a number of systems, including coagulation, complement response, inflammation, immune rejection, and recurrence of autoimmune disease. We have developed a surface modification and microencapsulation technique that protects cells and islets with biomaterials and bioactive substances, which may be useful in clinical settings. This approach employs amphiphilic polymers, which can interact with lipid bilayer membranes, without increasing cell volume. Molecules attached to these polymers can protect transplanted cells and islets from attack by the host immune system. We expect that this surface modification technique will improve graft survival in clinical islet transplantation.
authors: Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan, teramura@bioeng.t.u-tokyo.ac.jp.
authors: Yuji
authors: Y
authors: Teramura
authors: Sana
authors: S
authors: Asif
authors: Kristina N
authors: KN
authors: Ekdahl
authors: Bo
authors: B
authors: Nilsson
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D006085:Graft Survival; D055767:Immobilized Proteins / Q000737:chemistry / Q000276:immunology; D007515:Islets of Langerhans / Q000737:chemistry* / Q000166:cytology / Q000276:immunology; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000379:methods*; D008051:Lipid Bilayers / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011092:Polyethylene Glycols / Q000737:chemistry*; D014185:Transplantation, Isogeneic; D014568:Urokinase-Type Plasminogen Activator / Q000737:chemistry / Q000276:immunology
chemical_list: D001786:Blood Glucose; D055767:Immobilized Proteins; D008051:Lipid Bilayers; D011092:Polyethylene Glycols; D014568:Urokinase-Type Plasminogen Activator