title: Future Research Directions in Asthma. An NHLBI Working Group Report.
abstract: Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the NHLBI convened a group of extramural investigators for an Asthma Research Strategic Planning workshop on September 18-19, 2014, to accelerate discoveries and their translation to patients. The workshop focused on (1) in utero and early-life origins of asthma, (2) the use of phenotypes and endotypes to classify disease, (3) defining disease modification, (4) disease management, and (5) implementation research. This report summarizes the workshop and produces recommendations to guide future research in asthma.
authors: 1 Brigham and Women's Hospital, Boston, Massachusetts.
authors: Bruce D
authors: BD
authors: Levy
authors: 2 National Heart, Lung, and Blood Institute, Bethesda, Maryland.
authors: Patricia J
authors: PJ
authors: Noel
authors: 2 National Heart, Lung, and Blood Institute, Bethesda, Maryland.
authors: Michelle M
authors: MM
authors: Freemer
authors: 3 University of Connecticut Health Center, Hartford, Connecticut.
authors: Michelle M
authors: MM
authors: Cloutier
authors: 4 University of Rochester, Rochester, New York.
authors: Steve N
authors: SN
authors: Georas
authors: 5 University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
authors: Nizar N
authors: NN
authors: Jarjour
authors: 6 The University of Chicago, Chicago, Illinois.
authors: Carole
authors: C
authors: Ober
authors: 7 University of California at San Francisco, San Francisco, California.
authors: Prescott G
authors: PG
authors: Woodruff
authors: 8 Johns Hopkins University, Baltimore, Maryland.
authors: Kathleen C
authors: KC
authors: Barnes
authors: 9 National Jewish Health, Denver, Colorado.
authors: Bruce G
authors: BG
authors: Bender
authors: 10 Massachusetts General Hospital, Boston, Massachusetts.
authors: Carlos A
authors: CA
authors: Camargo
authors: 11 Yale University School of Medicine, New Haven, Connecticut.
authors: Geoff L
authors: GL
authors: Chupp
authors: 5 University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
authors: Loren C
authors: LC
authors: Denlinger
authors: 7 University of California at San Francisco, San Francisco, California.
authors: John V
authors: JV
authors: Fahy
authors: 12 Emory University School of Medicine, Atlanta, Georgia.
authors: Anne M
authors: AM
authors: Fitzpatrick
authors: 1 Brigham and Women's Hospital, Boston, Massachusetts.
authors: Anne
authors: A
authors: Fuhlbrigge
authors: 13 Case Western Reserve University, Cleveland, Ohio.
authors: Ben M
authors: BM
authors: Gaston
authors: 14 Vanderbilt University School of Medicine, Nashville, Tennessee.
authors: Tina V
authors: TV
authors: Hartert
authors: 15 University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors: Jay K
authors: JK
authors: Kolls
authors: 7 University of California at San Francisco, San Francisco, California.
authors: Susan V
authors: SV
authors: Lynch
authors: 16 Wake Forest School of Medicine, Winston Salem, North Carolina.
authors: Wendy C
authors: WC
authors: Moore
authors: 17 University of Arizona, Tucson, Arizona.
authors: Wayne J
authors: WJ
authors: Morgan
authors: 18 Stanford School of Medicine, Stanford, California.
authors: Kari C
authors: KC
authors: Nadeau
authors: 19 Georgia Regents University, Augusta, Georgia.
authors: Dennis R
authors: DR
authors: Ownby
authors: 6 The University of Chicago, Chicago, Illinois.
authors: Julian
authors: J
authors: Solway
authors: 20 Children's Hospital Colorado and the University of Colorado School of Medicine, Denver, Colorado.
authors: Stanley J
authors: SJ
authors: Szefler
authors: 15 University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors: Sally E
authors: SE
authors: Wenzel
authors: 21 Icahn School of Medicine at Mount Sinai, New York, New York; and.
authors: Rosalind J
authors: RJ
authors: Wright
authors: 2 National Heart, Lung, and Blood Institute, Bethesda, Maryland.
authors: Robert A
authors: RA
authors: Smith
authors: 22 Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio.
authors: Serpil C
authors: SC
authors: Erzurum
mesh_terms: D001249:Asthma / Q000503:physiopathology / Q000628:therapy*; D004493:Education; D006801:Humans; D054555:National Heart, Lung, and Blood Institute (U.S.); D012106:Research; D014481:United States
keywords: asthma; disease modification; implementation; phenotype; prevention