title: Repair of massively defected hemi-joints using demineralized osteoarticular allografts with protected cartilage.
abstract: Surgical replacement of massively defected joints necessarily relies on osteochondral grafts effective to both of bone and cartilage. Demineralized bone matrix (DBM) retains the osteoconductivity but destroys viable chondrocytes in the cartilage portion essential for successful restoration of defected joints. This study prepared osteochondral grafts of DBM with protected cartilage. Protected cartilage portions was characterized by cellular and molecular biology and the grafts were allogenically used for grafting. Protected cartilage showed similar histomorphological structure and protected proteins estimated by total proteins and cartilage specific proteins as in those of fresh controls when DBMs were generated in bone portions. Such grafts were successfully used for simultaneously repair of bone and cartilage in massively defected osteoarticular joints within 16 weeks post-surgery. These results present an allograft with clinical potential for simultaneous restoration of bone and cartilage in defected joints.
authors: Guangzhou Institute of Traumatic Surgery, The Fourth Affiliated Hospital, Jinan University School of Medicine, 396 Tongfu Zhonglu Road, Haizhu District, Guangzhou, 510220, Guangdong Province, People's Republic of China, drsmli@hotmail.com.
authors: Siming
authors: S
authors: Li
authors: Xiaohong
authors: X
authors: Yang
authors: Shenghui
authors: S
authors: Tang
authors: Xunmeng
authors: X
authors: Zhang
authors: Zhencheng
authors: Z
authors: Feng
authors: Shuliang
authors: S
authors: Cui
mesh_terms: D064591:Allografts; D000818:Animals; D001672:Biocompatible Materials; D016025:Bone Transplantation / Q000379:methods*; D002356:Cartilage / Q000293:injuries / Q000473:pathology / Q000637:transplantation*; D002358:Cartilage, Articular / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D019902:Chondrocytes / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D007596:Joints / Q000293:injuries* / Q000473:pathology / Q000601:surgery*; D016348:Osseointegration; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials