title: Effects of adiponectin polymorphisms on the risk of advanced age-related macular degeneration.
abstract: OBJECTIVE
  To determine the relationships between variants in adiponectin gene (ADIPOQ) with advanced forms of age-related macular degeneration (AMD) susceptibility.
  
  
  METHODS
  A total of 189 advanced AMD patients and 168 controls were recruited. Seven tagging single-nucleotide polymorphisms in ADIPOQ were genotyped by the SNaPshot method.
  
  
  RESULTS
  Alleles or genotypes of rs822396 distributed significantly differently in advanced AMD patients and controls. The minor allele G at rs822396 was associated with an increased risk of advanced AMD in a dominant model. Furthermore, haplotype analysis revealed that haplotypes AGGACCT and TGACCCC were significantly increased the advanced AMD susceptibility, whereas haplotypes AGAACGC, TGAACGT and TGACAGC had protective effects.
  
  
  CONCLUSIONS
  ADIPOQ genetic variant rs822396 might affect an individual's susceptibility to AMD, making it efficient genetic biomarkers for early detection of AMD.
authors: a Molecular Medicine Research Center, State Key Laboratory of Biotherapy and.
authors: Guiqun
authors: G
authors: Cao
authors: Yulong
authors: Y
authors: Chen
authors: Jinlong
authors: J
authors: Zhang
authors: Yulan
authors: Y
authors: Liu
authors: Ming
authors: M
authors: Zhang
authors: Kang
authors: K
authors: Zhang
authors: Zhiguang
authors: Z
authors: Su
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin
keywords: Adiponectin; SNPs; age-related macular degeneration; haplotype