title: Serum inflammatory markers in obese mice: Effect of ghrelin.
abstract: BACKGROUND
  Ghrelin is involved in modulation of food intake and energy homeostasis; however, it may play a role in cardiovascular system and atherosclerosis process. This study aimed to investigate the effect of ghrelin on serum inflammatory markers in control and obese mice.
  
  
  METHODS
  Ghrelin (100 mg/kg/day, twice daily) was administered interaperitoneally to control and diet-induced obese mice. After 10 days, blood samples were taken.
  
  
  RESULTS
  Results showed that administration of ghrelin did not change serum hsCRP level; however, it reduced serum IL-6 concentration in obese mice (P < 0.05).
  
  
  CONCLUSIONS
  It seems that the exact role and mechanism of ghrelin in prevention or treatment of atherosclerosis needs more studies.
authors: Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Majid
authors: M
authors: Khazaei
authors: Birjand University of Medical Sciences, Birjand, Iran.
authors: Zoya
authors: Z
authors: Tahergorabi
keywords: C-reactive protein; ghrelin; inflammation; interleukin-6; obesity