title: Keeping Oxidative Metabolism on Time: Mitochondria as an Autonomous Redox Pacemaker Animated by H2O2 and Peroxiredoxin.
abstract: In this issue of Molecular Cell, Kil et al. (2015) provide evidence for self-sustained circadian oscillations of the hyperoxidation of the mitochondrial Peroxiredoxin, PrxIII, and cytosolic release of mitochondrial H2O2, which might constitute one biochemical output coupling metabolic changes and transcriptional-based core clocks.
authors: Oxidative Stress and Cancer, IBITECS, SBIGEM, CEA-Saclay, 91191 Gif-sur-Yvette, France. Electronic address: michel.toledano@cea.fr.
authors: Michel B
authors: MB
authors: Toledano
authors: Oxidative Stress and Cancer, IBITECS, SBIGEM, CEA-Saclay, 91191 Gif-sur-Yvette, France.
authors: Agnès
authors: A
authors: Delaunay-Moisan
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000378:metabolism*
chemical_list: D050862:Oxidoreductases Acting on Sulfur Group Donors