title: Expanding the nasturlexin family: Nasturlexins C and D and their sulfoxides are phytoalexins of the crucifers Barbarea vulgaris and B. verna.
abstract: The metabolites produced in leaves of the crucifers winter cress (Barbarea vulgaris) and upland cress (Barbarea verna) abiotically elicited were investigated and their chemical structures were elucidated by analyses of spectroscopic data and confirmed by syntheses. Nasturlexins C and D and their sulfoxides are cruciferous phytoalexins displaying antifungal activity against the crucifer pathogens Alternaria brassicicola, Leptosphaeria maculans and Sclerotinia sclerotiorum. The biosynthesis of these metabolites is proposed based on pathways of cruciferous indolyl phytoalexins. This work indicates that B. vulgaris and B. verna have great potential as sources of defense pathways transferable to agriculturally important crops within the Brassica species.
authors: Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada. Electronic address: s.pedras@usask.ca.
authors: M Soledade C
authors: MS
authors: Pedras
authors: Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
authors: Mahla
authors: M
authors: Alavi
authors: Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
authors: Q Huy
authors: QH
authors: To
mesh_terms: D000528:Alternaria / Q000378:metabolism; D000935:Antifungal Agents / Q000737:chemistry; D001203:Ascomycota / Q000378:metabolism; D031216:Barbarea / Q000737:chemistry*; D001937:Brassica / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013454:Sulfoxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000094162:Phytoalexins
chemical_list: D000935:Antifungal Agents; D012717:Sesquiterpenes; D013454:Sulfoxides; C000608062:nasturlexin C; C000608063:nasturlexin D; D000094162:Phytoalexins
keywords: Alternaria brassicicola; Antifungal; B. verna; Barbarea vulgaris; Brassicaceae; Gluconasturtiin; Leptosphaeria maculans; Nasturlexin; Phytoalexin; Sclerotinia sclerotiorum