title: A Stewardship Approach To Optimize Antimicrobial Therapy through Use of a Rapid Microarray Assay on Blood Cultures Positive for Gram-Negative Bacteria.
abstract: A Gram-negative (GN) blood culture microarray assay with an antimicrobial stewardship program (ASP) intervention was evaluated in 126 patients with GN bacteremia. The median time to optimal therapy was shorter in the postintervention group than in the preintervention group (49.3 h versus 38.5 h, respectively; P = 0.0199). ASP can utilize microarray technology to decrease the time to optimal antimicrobial therapy.
authors: Department of Pharmacy, University of Florida Health Jacksonville, Jacksonville, Florida, USA.
authors: Conner
authors: C
authors: Sothoron
authors: Department of Pharmacy, University of Florida Health Jacksonville, Jacksonville, Florida, USA.
authors: Jason
authors: J
authors: Ferreira
authors: Department of Medicine, Division of Infectious Disease, University of Florida Health Jacksonville, Jacksonville, Florida, USA.
authors: Nilmarie
authors: N
authors: Guzman
authors: Center for Health Equity and Quality Research, Jacksonville, Florida, USA.
authors: Petra
authors: P
authors: Aldridge
authors: Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA yvette.mccarter@jax.ufl.edu christopher.jankowski@jax.ufl.edu.
authors: Yvette S
authors: YS
authors: McCarter
authors: Department of Pharmacy, University of Florida Health Jacksonville, Jacksonville, Florida, USA yvette.mccarter@jax.ufl.edu christopher.jankowski@jax.ufl.edu.
authors: Christopher A
authors: CA
authors: Jankowski
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D046228:Microarray Analysis / Q000379:methods*; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents