title: A low-fat yoghurt supplemented with a rooster comb extract on muscle joint function in adults with mild knee pain: a randomized, double blind, parallel, placebo-controlled, clinical trial of efficacy.
abstract: Preliminary results suggested that oral-administration of rooster comb extract (RCE) rich in hyaluronic acid (HA) was associated with improved muscle strength. Following these promising results, the objective of the present study was to evaluate the effect of low-fat yoghurt supplemented with RCE rich in HA on muscle function in adults with mild knee pain; a symptom of early osteoarthritis. Participants (n = 40) received low-fat yoghurt (125 mL d(-1)) supplemented with 80 mg d(-1) of RCE and the placebo group (n = 40) consumed the same yoghurt without the RCE, in a randomized, controlled, double-blind, parallel trial over 12 weeks. Using an isokinetic dynamometer (Biodex System 4), RCE consumption, compared to control, increased the affected knee peak torque, total work and mean power at 180° s(-1), at least 11% in men (p < 0.05) with no differences in women. No dietary differences were noted. These results suggest that long-term consumption of low-fat yoghurt supplemented with RCE could be a dietary tool to improve muscle strength in men, associated with possible clinical significance. However, further studies are needed to elucidate reasons for these sex difference responses observed, and may provide further insight into muscle function.
authors: Hospital Universitari Sant Joan, Reus, Spain. rosa.sola@urv.cat.
authors: Rosa
authors: R
authors: Solà
authors: Rosa-Maria
authors: RM
authors: Valls
authors: Isabel
authors: I
authors: Martorell
authors: Montserrat
authors: M
authors: Giralt
authors: Anna
authors: A
authors: Pedret
authors: Núria
authors: N
authors: Taltavull
authors: Marta
authors: M
authors: Romeu
authors: Àurea
authors: À
authors: Rodríguez
authors: David
authors: D
authors: Moriña
authors: Victor
authors: V
authors: Lopez de Frutos
authors: Manuel
authors: M
authors: Montero
authors: Maria-Carmen
authors: MC
authors: Casajuana
authors: Laura
authors: L
authors: Pérez
authors: Jenny
authors: J
authors: Faba
authors: Gloria
authors: G
authors: Bernal
authors: Anna
authors: A
authors: Astilleros
authors: Roser
authors: R
authors: González
authors: Francesc
authors: F
authors: Puiggrós
authors: Lluís
authors: L
authors: Arola
authors: Carlos
authors: C
authors: Chetrit
authors: Daniel
authors: D
authors: Martinez-Puig
mesh_terms: D000328:Adult; D000818:Animals; D018771:Arthralgia / Q000178:diet therapy / Q000188:drug therapy*; D002645:Chickens; D003129:Comb and Wattles / Q000737:chemistry*; D018752:Diet, Fat-Restricted; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000302:isolation & purification / Q000494:pharmacology*; D007719:Knee Joint / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects*; D012737:Sex Factors; D014020:Tissue Extracts / Q000737:chemistry; D015014:Yogurt
chemical_list: D014020:Tissue Extracts; D006820:Hyaluronic Acid