title: Potential Pitfall in the Assessment of Lung Cancer with FDG-PET/CT: Talc Pleurodesis Causes Intrathoracic Nodal FDG Avidity.
abstract: Objective. Talc pleurodesis is a common procedure performed to treat complications related to lung cancer. The purpose of our study was to characterize any thoracic nodal findings on FDG PET/CT associated with prior talc pleurodesis. Materials and Methods. The electronic medical record identified 44 patients who underwent PET/CT between January 2006 and December 2010 and had a history of talc pleurodesis. For each exam, we evaluated the distribution pattern, size, and attenuation of intrathoracic lymph nodes and the associated standardized uptake value. Results. High-attenuation intrathoracic lymph nodes were noted in 11 patients (25%), and all had corresponding increased FDG uptake (range 2-9 mm). Involved nodal groups were anterior peridiaphragmatic (100%), paracardiac (45%), internal mammary (25%), and peri-IVC (18%) nodal stations. Seven of the 11 patients (63%) had involvement of multiple lymph nodal groups. Mean longitudinal PET/CT and standalone CT followups of 15 ± 11 months showed persistence of both high-attenuation and increased uptake at these sites, without increase in nodal size suggesting metastatic disease involvement. Conclusions. FDG avid, high-attenuation lymph nodes along the lymphatic drainage pathway for parietal pleura are a relatively common finding following talc pleurodesis and should not be mistaken for nodal metastases during the evaluation of patients with history of lung cancer.
authors: Department of Radiology, Division of Thoracic Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
authors: Yingbing
authors: 0000-0002-3040-7368
authors: Y
authors: Wang
authors: Department of Radiology, Division of Thoracic Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
authors: Brett W
authors: BW
authors: Carter
authors: Department of Radiology, Division of Thoracic Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
authors: Victorine
authors: V
authors: Muse
authors: Department of Radiology, Division of Thoracic Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
authors: Subba
authors: S
authors: Digumarthy
authors: Department of Radiology, Division of Thoracic Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
authors: Jo-Anne
authors: JA
authors: Shepard
authors: Department of Radiology, Division of Thoracic Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
authors: Amita
authors: A
authors: Sharma