title: Effect of Growth Hormone Treatment on Fractures and Quality of Life in Postmenopausal Osteoporosis: A 10-Year Follow-Up Study.
abstract: BACKGROUND
  Growth hormone (GH) treatment increases bone mineral density (BMD) in women with postmenopausal osteoporosis.
  
  
  OBJECTIVE
  The objective was to report bone data, fractures, and quality of life (QoL) in a 10-year follow-up of women who had received GH for 3 years and compared with controls followed in parallel.
  
  
  METHODS
  A follow-up of a double-blind, placebo-controlled study conducted at Sahlgrenska University Hospital was performed.
  
  
  METHODS
  Eighty women aged between 50 and 70 years with osteoporosis and estrogen hormone replacement were studied and compared with an age-matched random population sample of women (n = 120) from the World Health Organization Monitoring of Trends and Determinants in Cardiovascular Disease project (Gothenburg, Sweden).
  
  
  METHODS
  Patients were randomized to GH 1.0 U or GH 2.5 U recombinant human GH or placebo sc daily during 3 years. All received calcium 750 mg and vitamin D 400 U and were followed up during 10 years.
  
  
  METHODS
  BMD and bone mineral content were measured with dual-energy X-ray absorptiometry. QoL was estimated with the 36-item Short Form.
  
  
  RESULTS
  GH increased BMD and bone mineral content dose dependently in all regions (P = .01, GH 1.0 U, and P = .0006, GH 2.5 U vs placebo). After 10 years the number of fractures decreased from 56% to 28% (P = .0003) in patients evenly distributed between groups. In controls, fractures increased from 8% to 32% (P = .0008). QoL did not change during GH treatment or during the 10-year follow-up and did not differ compared with controls.
  
  
  CONCLUSIONS
  GH treatment was beneficial for bone and fracture outcome after 10 years but did not affect the QoL of the women with postmenopausal osteoporosis.
authors: Clinic for Internal Medicine (E.K.), Södra Älvsborgs Hospital, SE-501 82 Borås, Sweden; and Section for Endocrinology (P.T., K.L.-W.), Sahlgrenska University Hospital at Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
authors: Emily
authors: E
authors: Krantz
authors: Clinic for Internal Medicine (E.K.), Södra Älvsborgs Hospital, SE-501 82 Borås, Sweden; and Section for Endocrinology (P.T., K.L.-W.), Sahlgrenska University Hospital at Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
authors: Penelope
authors: P
authors: Trimpou
authors: Clinic for Internal Medicine (E.K.), Södra Älvsborgs Hospital, SE-501 82 Borås, Sweden; and Section for Endocrinology (P.T., K.L.-W.), Sahlgrenska University Hospital at Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
authors: Kerstin
authors: K
authors: Landin-Wilhelmsen
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D019382:Human Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D011788:Quality of Life; D016896:Treatment Outcome; D014807:Vitamin D / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D019382:Human Growth Hormone; D014807:Vitamin D; D002118:Calcium