title: Field Guide to Challenges and Opportunities in Antibody-Drug Conjugates for Chemists.
abstract: Antibody-drug conjugates have attracted a great amount of attention as a therapeutic strategy for diseases where targeting specific tissues and cells are critical components, such as in cancer therapy. Although promising, the number of approved ADC drugs is relatively limited. This emanates from the challenges associated with generating the conjugates and the complexities associated with the stability requirements for these conjugates during circulation and after reaching the target. Here, we provide a comprehensive overview of the design challenges facing the ADC field. These challenges also provide several unique research and development opportunities, which are also highlighted throughout the review.
authors: Department of Chemistry, ‡Molecular and Cellular Biology Program, and §Department of Veterinary and Animal Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors: Mallory R
authors: MR
authors: Gordon
authors: Department of Chemistry, ‡Molecular and Cellular Biology Program, and §Department of Veterinary and Animal Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors: Mine
authors: M
authors: Canakci
authors: Department of Chemistry, ‡Molecular and Cellular Biology Program, and §Department of Veterinary and Animal Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors: Longyu
authors: L
authors: Li
authors: Department of Chemistry, ‡Molecular and Cellular Biology Program, and §Department of Veterinary and Animal Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors: Jiaming
authors: J
authors: Zhuang
authors: Department of Chemistry, ‡Molecular and Cellular Biology Program, and §Department of Veterinary and Animal Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors: Barbara
authors: B
authors: Osborne
authors: Department of Chemistry, ‡Molecular and Cellular Biology Program, and §Department of Veterinary and Animal Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors: S
authors: S
authors: Thayumanavan
mesh_terms: D000818:Animals; D055162:Biocatalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry*; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry
chemical_list: D018796:Immunoconjugates