title: Defining the null hypothesis.
abstract: Virus B is a newly emerged viral strain for which there is no current treatment. Drug A was identified as a potential treatment for infection with virus B. In this pre-clinical phase of drug testing, the effects of drug A on survival after infection with virus B was tested. There was no difference in survival between control (dark blue) and drug A-treated, virus B-infected mice (green), but a significant difference in survival between control and virus B-infected mice without drug treatment (light blue, z-test for proportions P < 0.05, n = 30 in each group). The authors therefore concluded that drug A is effective in reducing mouse mortality due to virus B.
authors: BMC Biology, BioMed Central, 236 Gray's Inn Road, London, WC1X 8HB, UK. BMCBiologyEditorial@biomedcentral.com.
authors: Emma
authors: E
authors: Saxon
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D051379:Mice; D015233:Models, Statistical; D014777:Virus Diseases / Q000188:drug therapy; D014780:Viruses / Q000187:drug effects
chemical_list: D000998:Antiviral Agents