title: Lipid Multilayer Grating Arrays Integrated by Nanointaglio for Vapor Sensing by an Optical Nose.
abstract: Lipid multilayer gratings are recently invented nanomechanical sensor elements that are capable of transducing molecular binding to fluid lipid multilayers into optical signals in a label free manner due to shape changes in the lipid nanostructures. Here, we show that nanointaglio is suitable for the integration of chemically different lipid multilayer gratings into a sensor array capable of distinguishing vapors by means of an optical nose. Sensor arrays composed of six different lipid formulations are integrated onto a surface and their optical response to three different vapors (water, ethanol and acetone) in air as well as pH under water is monitored as a function of time. Principal component analysis of the array response results in distinct clustering indicating the suitability of the arrays for distinguishing these analytes. Importantly, the nanointaglio process used here is capable of producing lipid gratings out of different materials with sufficiently uniform heights for the fabrication of an optical nose.
authors: Department of Biological Science and Integrative Nanoscience Institute, Florida State University, 89 Chieftan Way, Tallahassee, FL 32304, USA. twl10@my.fsu.edu.|Department of Physics, Florida State University, 77 Chieftan Way, Tallahassee, FL 32304, USA. twl10@my.fsu.edu.
authors: Troy W
authors: TW
authors: Lowry
authors: Department of Physics, Florida State University, 77 Chieftan Way, Tallahassee, FL 32304, USA. pp11d@my.fsu.edu.
authors: Plengchart
authors: P
authors: Prommapan
authors: Department of Biological Science and Integrative Nanoscience Institute, Florida State University, 89 Chieftan Way, Tallahassee, FL 32304, USA. qr13@my.fsu.edu.
authors: Quinn
authors: Q
authors: Rainer
authors: Department of Physics, Florida State University, 77 Chieftan Way, Tallahassee, FL 32304, USA. rip@phy.fsu.edu.
authors: David
authors: D
authors: Van Winkle
authors: Department of Biological Science and Integrative Nanoscience Institute, Florida State University, 89 Chieftan Way, Tallahassee, FL 32304, USA. lenhert@bio.fsu.edu.
authors: Steven
authors: S
authors: Lenhert
mesh_terms: D062609:Electronic Nose; D005740:Gases / Q000032:analysis*; D006813:Humidity; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation*; D055620:Optical Phenomena; D025341:Principal Component Analysis
chemical_list: D005740:Gases; D008055:Lipids
keywords: AFM; lipid; lipid multilayer; materials integration; microcontract printing; nanofabrication; nanointaglio; nanotechnology; sensor; sensor-array