title: Clinical Significance of MET Gene Copy Number in Patients with Curatively Resected Gastric Cancer.
abstract: The present study analyzed the prognostic impact of MET gene copy number in patients with curatively resected gastric cancer who received a combination regimen of cisplatin and S-1. The MET gene copy number was analyzed by use of quantitative real-time polymerase chain reaction. From January 2006 to July 2010, 70 tumor samples from 74 patients enrolled in a pilot study were analyzed. According to a cutoff MET gene copy number of ≥2 copies, a high MET gene copy number was observed in 38 patients (54.3%). The characteristics of the 2 groups divided according to MET gene copy number were similar. With a median follow-up duration of 26.4 months (range, 2.6-73.2 months), the estimated 3-year relapse-free survival and overall survival rates were 54.3% and 77.4%, respectively. No significant association was observed between the MET gene copy number and survival in a multivariate analysis. The MET gene copy number investigated in this study was not found to be associated with prognosis in patients with curatively resected gastric cancer.
authors: Department of Hematology-Oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Byung Woog
authors: BW
authors: Kang
authors: Department of Hematology-Oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Jong Gwang
authors: JG
authors: Kim
authors: Department of Hematology-Oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Heyoung
authors: H
authors: Park
authors: Department of Hematology-Oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Bo Eun
authors: BE
authors: Park
authors: Department of Gastroenterology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Seong Woo
authors: SW
authors: Jeon
authors: Department of Pathology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Han Ik
authors: HI
authors: Bae
authors: Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Oh-Kyoung
authors: OK
authors: Kwon
authors: Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Ho Young
authors: HY
authors: Chung
authors: Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Wansik
authors: W
authors: Yu
keywords: Chemotherapy, Adjuvant; MET; Prognosis; Stomach neoplasms