title: Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response.
abstract: Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in biofilm infection microbiology, biofilm formation mechanisms and biofilm-associated antimicrobial tolerance has become an important area in microbiology. Substantial knowledge about biofilm formation mechanisms, biofilm-associated antimicrobial tolerance and immune evasion mechanisms has been obtained through work with biofilms grown in in vitro experimental setups, and the relevance of this information in the context of chronic infections is being investigated by the use of animal models of infection. Because our current in vitro experimental setups and animal models have limitations, new advanced in vitro models developed with knowledge about the chemical landscape at infectious sites are needed.
authors: Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
authors: Morten
authors: M
authors: Rybtke
authors: Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
authors: Louise Dahl
authors: LD
authors: Hultqvist
authors: Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Singapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 637551, Republic of Singapore.
authors: Michael
authors: M
authors: Givskov
authors: Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark. Electronic address: ttn@sund.ku.dk.
authors: Tim
authors: T
authors: Tolker-Nielsen
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000382:microbiology; D005109:Extracellular Matrix / Q000737:chemistry; D005547:Foreign Bodies / Q000382:microbiology; D006801:Humans; D057131:Immune Evasion; D008297:Male; D010033:Otitis Media / Q000382:microbiology; D011472:Prostatitis / Q000382:microbiology; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000276:immunology* / Q000472:pathogenicity* / Q000502:physiology; D014946:Wound Infection / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Pseudomonas aeruginosa; antimicrobial tolerance; biofilm; structure