title: Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1.
abstract: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen. Because of its expression on the cell surface of leukemia cells from patients with chronic lymphocytic leukemia (CLL), but not on normal B-cells or other postpartum tissues, ROR1 is an attractive candidate for targeted therapies. UC-961 is a first-in-class humanized monoclonal antibody that binds the extracellular domain of ROR1. In this article we outline some of the preclinical studies leading to an investigational new drug designation, enabling clinical studies in patients with CLL.
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA.
authors: Michael Y
authors: MY
authors: Choi
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA.
authors: George F
authors: GF
authors: Widhopf
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA.
authors: Christina C N
authors: CC
authors: Wu
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA.
authors: Bing
authors: B
authors: Cui
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA.
authors: Fitzgerald
authors: F
authors: Lao
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA; Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA.
authors: Anil
authors: A
authors: Sadarangani
authors: Access Bio, Boyce, VA.
authors: Joy
authors: J
authors: Cavagnaro
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA.
authors: Charles
authors: C
authors: Prussak
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA.
authors: Dennis A
authors: DA
authors: Carson
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA; Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA.
authors: Catriona
authors: C
authors: Jamieson
authors: Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA. Electronic address: tkipps@ucsd.edu.
authors: Thomas J
authors: TJ
authors: Kipps
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D017209:Apoptosis; D045744:Cell Line, Tumor; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D057050:Receptor Tyrosine Kinase-like Orphan Receptors
keywords: AKT; CLL; Cirmtuzumab; Wnt receptor; cancer stem cell