title: Health Informatics via Machine Learning for the Clinical Management of Patients.
abstract: OBJECTIVE
  To review how health informatics systems based on machine learning methods have impacted the clinical management of patients, by affecting clinical practice.
  
  
  METHODS
  We reviewed literature from 2010-2015 from databases such as Pubmed, IEEE xplore, and INSPEC, in which methods based on machine learning are likely to be reported. We bring together a broad body of literature, aiming to identify those leading examples of health informatics that have advanced the methodology of machine learning. While individual methods may have further examples that might be added, we have chosen some of the most representative, informative exemplars in each case.
  
  
  RESULTS
  Our survey highlights that, while much research is taking place in this high-profile field, examples of those that affect the clinical management of patients are seldom found. We show that substantial progress is being made in terms of methodology, often by data scientists working in close collaboration with clinical groups.
  
  
  CONCLUSIONS
  Health informatics systems based on machine learning are in their infancy and the translation of such systems into clinical management has yet to be performed at scale.
authors: David A. Clifton, Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK, E-mail: davidc@robots.ox.ac.uk.
authors: D A
authors: DA
authors: Clifton
authors: K E
authors: KE
authors: Niehaus
authors: P
authors: P
authors: Charlton
authors: G W
authors: GW
authors: Colopy
mesh_terms: D057225:Data Mining; D057286:Electronic Health Records; D006801:Humans; D007362:Intensive Care Units / Q000458:organization & administration*; D000069550:Machine Learning; D008490:Medical Informatics; D010346:Patient Care Management
keywords: Health informatics; data mining; electronic health records; information systems