title: Karyotype evolution and acquisition of FLT3 or RAS pathway alterations drive progression of myelodysplastic syndrome to acute myeloid leukemia.
authors: MLL Munich Leukemia Laboratory, Munich, Germany.
authors: Manja
authors: M
authors: Meggendorfer
authors: MLL Munich Leukemia Laboratory, Munich, Germany.
authors: Andreia
authors: A
authors: de Albuquerque
authors: MLL Munich Leukemia Laboratory, Munich, Germany.
authors: Niroshan
authors: N
authors: Nadarajah
authors: MLL Munich Leukemia Laboratory, Munich, Germany.
authors: Tamara
authors: T
authors: Alpermann
authors: MLL Munich Leukemia Laboratory, Munich, Germany.
authors: Wolfgang
authors: W
authors: Kern
authors: MLL Munich Leukemia Laboratory, Munich, Germany.
authors: Kimberly
authors: K
authors: Steuer
authors: MLL2 s.r.o., Praha, Czech Republic.
authors: Karolína
authors: K
authors: Perglerová
authors: MLL Munich Leukemia Laboratory, Munich, Germany.
authors: Claudia
authors: C
authors: Haferlach
authors: MLL Munich Leukemia Laboratory, Munich, Germany.
authors: Susanne
authors: S
authors: Schnittger
authors: MLL Munich Leukemia Laboratory, Munich, Germany torsten.haferlach@mll.com.
authors: Torsten
authors: T
authors: Haferlach
mesh_terms: D059786:Abnormal Karyotype; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*; D018631:ras Proteins / Q000235:genetics*
chemical_list: C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3; D018631:ras Proteins
keywords: MDS; mutation analysis; s-AML