title: Comparative Assessment of Different Health Utility Measures in Systemic Lupus Erythematosus.
abstract: In a time of increasing economic constraints, it is crucial that health systems optimize their resource use to ensure that they generate the maximum possible health gain. Therefore, it is necessary for health interventions to be evaluated and compared across therapeutic boundaries. Undertaking such an evaluation a generic utility-based measure is required. But it remains uncertain whether the utility values obtained by direct or indirect methods are comparable and which approach is the most appropriate in Systemic Lupus Erythematosus (SLE) population. In the study, we compared the utility values obtained by an indirect method (EQ-5D) with direct utility instruments, the standard gamble (SG) and visual analog scale (VAS), in SLE patients. The correlations between VAS, EQ-5D and LupusQoL were significant; relative good intraclass correlations or kappa coefficients indicated the reliability of these instruments. A model incorporating the SLEDAI scores and LupusQoL domains of emotional health and pain was a good predictor of VAS. SLEDAI score was a good predictor in the SG regression model. These findings suggested that the VAS and EQ-5D might be valid and reliable measures to assess health related quality of life in SLE patients and represent promising outcome measures for future research in this population.
authors: Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Su-Li
authors: SL
authors: Wang
authors: Yale School of Medicine, The Anlyan Center, New Haven, Connecticut, United States of America.
authors: Evelyn
authors: E
authors: Hsieh
authors: Yale School of Medicine, The Anlyan Center, New Haven, Connecticut, United States of America.
authors: Li-An
authors: LA
authors: Zhu
authors: Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Bin
authors: B
authors: Wu
authors: Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Liang-Jing
authors: LJ
authors: Lu
mesh_terms: D000328:Adult; D003710:Demography; D005260:Female; D006304:Health Status; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000628:therapy*; D008297:Male; D010342:Patient Acceptance of Health Care; D011788:Quality of Life; D012044:Regression Analysis; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric