title: Azathioprine-induced accelerated cutaneous and pulmonary nodulosis in a patient with rheumatoid arthritis.
abstract: We report the case of a 42-year-old female with a 5-year history of rheumatoid arthritis treated with Rituximab and Azathioprine. Three months after the initiation of Azathioprine, the patient started with dry cough and noted the rapid development of multiple subcutaneous nodules on her right leg. CT scan of the chest demonstrates pulmonary nodulosis. Skin biopsy was compatible with rheumatoid nodule. A diagnosis of "accelerated cutaneous and pulmonary nodulosis" was considered. Azathioprine was discontinued and Rituximab was restarted. Two months later, most of the subcutaneous nodules had disappeared. This is the second case report of accelerated rheumatoid nodulosis in association with Azathioprine treatment.
authors: Pontificia Universidad Catolica de Chile, Santiago, CL.
authors: Cristian Vera
authors: CV
authors: Kellet
authors: Pontificia Universidad Catolica de Chile, Santiago, CL.
authors: Romina Andino
authors: RA
authors: Navarrete
authors: Pontificia Universidad Catolica de Chile, Santiago, CL.
authors: Sergio González
authors: SG
authors: Bombardieri
authors: Pontificia Universidad Catolica de Chile, Santiago, CL.
authors: Juan
authors: J
authors: Manriquez
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001379:Azathioprine / Q000009:adverse effects*; D001706:Biopsy; D005260:Female; D006801:Humans; D055613:Multiple Pulmonary Nodules / Q000139:chemically induced* / Q000473:pathology; D012218:Rheumatoid Nodule / Q000139:chemically induced* / Q000473:pathology; D000069283:Rituximab / Q000009:adverse effects; D012867:Skin / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D018501:Antirheumatic Agents; D000069283:Rituximab; D001379:Azathioprine