title: Acute effect of fine particulate matter on mortality in three Southeastern states from 2007-2011.
abstract: Epidemiologic studies on acute effects of air pollution have generally been limited to larger cities, leaving questions about rural populations behind. Recently, we had developed a spatiotemporal model to predict daily PM2.5 level at a 1 km(2) using satellite aerosol optical depth (AOD) data. Based on the results from the model, we applied a case-crossover study to evaluate the acute effect of PM2.5 on mortality in North Carolina, South Carolina, and Georgia between 2007 and 2011. Mortality data were acquired from the Departments of Public Health in the States and modeled PM2.5 exposures were assigned to the zip code of residence of each decedent. We performed various stratified analyses by age, sex, race, education, cause of death, residence, and environmental protection agency (EPA) standards. We also compared results of analyses using our modeled PM2.5 levels and those imputed daily from the nearest monitoring station. 848,270 non-accidental death records were analyzed and we found each 10 μg/m(3) increase in PM2.5 (mean lag 0 and lag 1) was associated with a 1.56% (1.19 and 1.94) increase in daily deaths. Cardiovascular disease (2.32%, 1.57-3.07) showed the highest effect estimate. Blacks (2.19%, 1.43-2.96) and persons with education ≤ 8 year (3.13%, 2.08-4.19) were the most vulnerable populations. The effect of PM2.5 on mortality still exists in zip code areas that meet the PM2.5 EPA annual standard (2.06%, 1.97-2.15). The effect of PM2.5 below both EPA daily and annual standards was 2.08% (95% confidence interval=1.99-2.17). Our results showed more power and suggested that the PM2.5 effects on rural populations have been underestimated due to selection bias and information bias. We have demonstrated that our AOD-based exposure models can be successfully applied to epidemiologic studies. This will add new study populations in rural areas, and will confer more generalizability to conclusions from such studies.
authors: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
authors: Mihye
authors: M
authors: Lee
authors: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
authors: Petros
authors: P
authors: Koutrakis
authors: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
authors: Brent
authors: B
authors: Coull
authors: Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel.
authors: Itai
authors: I
authors: Kloog
authors: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
authors: Joel
authors: J
authors: Schwartz
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D015982:Bias; D002318:Cardiovascular Diseases / Q000401:mortality*; D002423:Cause of Death; D018592:Cross-Over Studies; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D010316:Particle Size; D052638:Particulate Matter / Q000009:adverse effects* / Q000032:analysis; D011635:Public Health Administration; D012307:Risk Factors; D012424:Rural Population; D017678:Sex Distribution; D015144:Southeastern United States / Q000453:epidemiology; D062211:Spatio-Temporal Analysis; D020521:Stroke / Q000401:mortality
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter