title: Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent.
abstract: Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.
authors: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors: Maria Victória
authors: MV
authors: Quaresma
authors: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors: Fred
authors: F
authors: Bernardes Filho
authors: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors: Janaína
authors: J
authors: Hezel
authors: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors: Murilo Calvo
authors: MC
authors: Peretti
authors: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors: Bernard Kawa
authors: BK
authors: Kac
authors: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors: Luna
authors: L
authors: Azulay-Abulafia
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D017024:Chemotherapy, Adjuvant; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005493:Folic Acid Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008099:Liver / Q000187:drug effects; D008875:Middle Aged; D010392:Pemphigus / Q000188:drug therapy* / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005493:Folic Acid Antagonists; D005938:Glucocorticoids; D003622:Dapsone; D011241:Prednisone