title: Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer.
abstract: Hyperthermic intraperitoneal chemotherapy is effective in treating various intra-abdominal malignancies. However, this therapeutic modality can only be performed during surgical operations and cannot be used repeatedly. We propose repeatedly noninvasive hyperthermia mediated by pegylated silica-core gold nanoshells (pSGNs) in vivo with external near-infrared (NIR) laser irradiation. This study demonstrated that repeated photothermal treatment can effectively eliminate intraperitoneal tumors in mouse ovarian cancer models without damage of normal tissues. By conjugating pSGNs with anti-human CD47 monoclonal antibody, a significant photoablative effect can be achieved using lower amount of pSGNs and shorter NIR laser irradiation. Conjugated pSGNs specifically targeted and bound to cancer cells inside the peritoneal cavity. Our results indicate the possibility of a noninvasive method of repeated hyperthermia and photoablative therapies using nanoparticles. This has substantial clinical potential in treating ovarian and other intraperitoneal cancers.
authors: Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei City, Taiwan.|Department of Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan.
authors: Chao-Chih
authors: CC
authors: Wu
authors: Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei City, Taiwan.
authors: Yuh-Cheng
authors: YC
authors: Yang
authors: Department of Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan.
authors: Yun-Ting
authors: YT
authors: Hsu
authors: Department of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA.|Department of Oncology, The Johns Hopkins University, Baltimore, Maryland, USA.|Department of Obstetrics and Gynecology, The Johns Hopkins University, Baltimore, Maryland, USA.|Department of Molecular Microbiology and Immunology, The Johns Hopkins University, Baltimore, Maryland, USA.
authors: T-C
authors: TC
authors: Wu
authors: Department of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA.|Department of Oncology, The Johns Hopkins University, Baltimore, Maryland, USA.|Department of Obstetrics and Gynecology, The Johns Hopkins University, Baltimore, Maryland, USA.|Department of Molecular Microbiology and Immunology, The Johns Hopkins University, Baltimore, Maryland, USA.
authors: Chien-Fu
authors: CF
authors: Hung
authors: Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei City, Taiwan.
authors: Jung-Tang
authors: JT
authors: Huang
authors: Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei City, Taiwan.|Department of Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan.|Department of Medicine, Mackay Medical College, Sanchi, New Taipei City, Taiwan.
authors: Chih-Long
authors: CL
authors: Chang
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D051928:CD47 Antigen / Q000378:metabolism; D005260:Female; D006046:Gold / Q000737:chemistry; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D007834:Lasers; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D057145:Nanoshells / Q000737:chemistry*; D010051:Ovarian Neoplasms / Q000628:therapy*; D010537:Peritoneum / Q000473:pathology*; D010789:Phototherapy / Q000379:methods*; D020349:Surface Plasmon Resonance
chemical_list: D000911:Antibodies, Monoclonal; D051928:CD47 Antigen; D006046:Gold
keywords: gold nanoshells; hypethermia; ovarian cancer