title: Pharmacogenetics of Bisphosphonate-associated Osteonecrosis of the Jaw.
abstract: Osteonecrosis of the jaws (ONJ) is a potentially severe disorder that develops in a subgroup of individuals who have used bisphosphonate (BP) medications. Several clinical risk factors have been associated with the risk of ONJ development, but evidence is limited and in most instances ONJ remains an unpredictable adverse drug reaction. Interindividual genetic variability can contribute to explaining ONJ development in a subset of BP users and the discovery of relevant associated gene variants could lead to the identification of individuals at higher risk. No genetic variant has been found to be robustly associated with susceptibility to ONJ.
authors: UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK.
authors: P L
authors: PL
authors: Fung
authors: Department of Systems Biology, Irving Cancer Research Center, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA.
authors: P
authors: P
authors: Nicoletti
authors: Department of Systems Biology, Irving Cancer Research Center, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA; Department of Biomedical Informatics, Irving Cancer Research Center, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA.
authors: Y
authors: Y
authors: Shen
authors: UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK.
authors: S
authors: S
authors: Porter
authors: UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK; NIHR Biomedical Research Centre, University College London Hospitals, 149 Tottenham Court Road, London W1T 7DN, UK. Electronic address: s.fedele@ucl.ac.uk.
authors: S
authors: S
authors: Fedele
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000235:genetics*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans; D010597:Pharmacogenetics; D012307:Risk Factors
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: Bisphosphonates; Genes; Jaw osteonecrosis; Pharmacogenetics; Pharmacogenomics; Single-nucleotide polymorphisms