title: A "Sense-and-Treat" Hydrogel Used for Treatment of Bacterial Infection on the Solid Matrix.
abstract: A "sense-and-treat" hydrogel is constructed for sensing and inhibiting bacterial infection. Without bacteria, the hydrogel emits green fluorescence. With bacterial infection, the hydrogel emits red fluorescence and releases Vancomycin to kill bacteria.
authors: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.|University of Chinese Academy of Sciences, Beijing, 100039, China.
authors: Zhengqing
authors: Z
authors: Yan
authors: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.|University of Chinese Academy of Sciences, Beijing, 100039, China.
authors: Peng
authors: P
authors: Shi
authors: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors: Jinsong
authors: J
authors: Ren
authors: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors: Xiaogang
authors: X
authors: Qu
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis; D004058:Diffusion; D020100:Hydrogels / Q000737:chemistry / Q000627:therapeutic use*; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014640:Vancomycin / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D020100:Hydrogels; D053769:Nanocapsules; D014640:Vancomycin
keywords: antibacterials; drug release; pH-sensitive hydrogels; ratiometric fluorescence; sense-and-treat