title: Fluid-Structure Interaction Model of a Percutaneous Aortic Valve: Comparison with an In Vitro Test and Feasibility Study in a Patient-Specific Case.
abstract: Transcatheter aortic valve replacement (TAVR) represents an established recent technology in a high risk patient base. To better understand TAVR performance, a fluid-structure interaction (FSI) model of a self-expandable transcatheter aortic valve was proposed. After an in vitro durability experiment was done to test the valve, the FSI model was built to reproduce the experimental test. Lastly, the FSI model was used to simulate the virtual implant and performance in a patient-specific case. Results showed that the leaflet opening area during the cycle was similar to that of the in vitro test and the difference of the maximum leaflet opening between the two methodologies was of 0.42%. Furthermore, the FSI simulation quantified the pressure and velocity fields. The computed strain amplitudes in the stent frame showed that this distribution in the patient-specific case is highly affected by the aortic root anatomy, suggesting that the in vitro tests that follow standards might not be representative of the real behavior of the percutaneous valve. The patient-specific case also compared in vivo literature data on fast opening and closing characteristics of the aortic valve during systolic ejection. FSI simulations represent useful tools in determining design errors or optimization potentials before the fabrication of aortic valve prototypes and the performance of tests.
authors: Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.
authors: Wei
authors: W
authors: Wu
authors: Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz-Institute, RWTH Aachen University, Aachen, Germany.
authors: Desiree
authors: D
authors: Pott
authors: Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.
authors: Beniamino
authors: B
authors: Mazza
authors: Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.
authors: Tommaso
authors: T
authors: Sironi
authors: Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.
authors: Elena
authors: E
authors: Dordoni
authors: Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.|Department of Biomedical Engineering, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors: Claudio
authors: C
authors: Chiastra
authors: Department of Civil and Environmental Engineering, Politecnico di Milano, Milan, Italy.
authors: Lorenza
authors: L
authors: Petrini
authors: Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.
authors: Giancarlo
authors: G
authors: Pennati
authors: Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.
authors: Gabriele
authors: G
authors: Dubini
authors: Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz-Institute, RWTH Aachen University, Aachen, Germany.
authors: Ulrich
authors: U
authors: Steinseifer
authors: Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz-Institute, RWTH Aachen University, Aachen, Germany.
authors: Simon
authors: S
authors: Sonntag
authors: Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz-Institute, RWTH Aachen University, Aachen, Germany.
authors: Maximilian
authors: M
authors: Kuetting
authors: Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy. francesco.migliavacca@polimi.it.
authors: Francesco
authors: F
authors: Migliavacca
mesh_terms: D001021:Aortic Valve / Q000503:physiopathology* / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008955:Models, Cardiovascular; D013314:Stress, Mechanical; D065467:Transcatheter Aortic Valve Replacement
keywords: Fluid–structure interaction; Mathematical models; Stent; Transcatheter aortic valve; Valve mechanics