title: Effect of postprandial hyperglycaemia on coronary flow reserve in patients with impaired glucose tolerance and type 2 diabetes mellitus.
abstract: BACKGROUND
  This study investigated whether postprandial hyperglycaemia has an adverse effect on coronary microvascular function and left ventricular diastolic function.
  
  
  METHODS
  In all, 28 patients with type 2 diabetes mellitus with no significant stenosis in left anterior descending artery were enrolled. In all subjects, plasma 1,5-anhydroglucitol was measured, and coronary flow reserve in the left anterior descending artery was evaluated using a Doppler wire. Membrane type-1 matrix metalloproteinase expression on circulating peripheral blood mononuclear cells was measured by flow cytometry. Correlation analyses were performed for coronary flow reserve and 1,5-anhydroglucitol, other coronary risk factors, membrane type-1 matrix metalloproteinase and E/e'.
  
  
  RESULTS
  Strong correlations were found only between 1,5-anhydroglucitol and coronary flow reserve and membrane type-1 matrix metalloproteinase. On multiple regression analysis, 1,5-anhydroglucitol remained an independent predictor of coronary flow reserve (β = 0.38, p = 0.048).
  
  
  CONCLUSIONS
  Postprandial hyperglycaemia appears to have an adverse effect on coronary microvascular function, suggesting that improvement of postprandial hyperglycaemia may contribute to the improvement of coronary microvascular dysfunction.
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Hiroyuki
authors: H
authors: Ikeda
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan huzui@u-fukui.ac.jp.
authors: Hiroyasu
authors: H
authors: Uzui
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Tetsuji
authors: T
authors: Morishita
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Yoshitomo
authors: Y
authors: Fukuoka
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Takehiko
authors: T
authors: Sato
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Kentaro
authors: K
authors: Ishida
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Kenichi
authors: K
authors: Kaseno
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Kenichiro
authors: K
authors: Arakawa
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Naoki
authors: N
authors: Amaya
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Naoto
authors: N
authors: Tama
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Yuichiro
authors: Y
authors: Shiomi
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Jong-Dae
authors: JD
authors: Lee
authors: Department of Cardiovascular Medicine, University of Fukui, Eiheiji-cho, Japan.
authors: Hiroshi
authors: H
authors: Tada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003326:Coronary Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000503:physiopathology*; D003847:Deoxyglucose / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000628:therapy*; D005260:Female; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
chemical_list: C006584:1,5-anhydroglucitol; D003847:Deoxyglucose; D005947:Glucose
keywords: Postprandial hyperglycaemia; coronary flow reserve; coronary heart disease