title: MEXPRESS: visualizing expression, DNA methylation and clinical TCGA data.
abstract: BACKGROUND
  In recent years, increasing amounts of genomic and clinical cancer data have become publically available through large-scale collaborative projects such as The Cancer Genome Atlas (TCGA). However, as long as these datasets are difficult to access and interpret, they are essentially useless for a major part of the research community and their scientific potential will not be fully realized. To address these issues we developed MEXPRESS, a straightforward and easy-to-use web tool for the integration and visualization of the expression, DNA methylation and clinical TCGA data on a single-gene level ( http://mexpress.be ).
  
  
  RESULTS
  In comparison to existing tools, MEXPRESS allows researchers to quickly visualize and interpret the different TCGA datasets and their relationships for a single gene, as demonstrated for GSTP1 in prostate adenocarcinoma. We also used MEXPRESS to reveal the differences in the DNA methylation status of the PAM50 marker gene MLPH between the breast cancer subtypes and how these differences were linked to the expression of MPLH.
  
  
  CONCLUSIONS
  We have created a user-friendly tool for the visualization and interpretation of TCGA data, offering clinical researchers a simple way to evaluate the TCGA data for their genes or candidate biomarkers of interest.
authors: Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium. alexander.koch@ugent.be.|Department of Mathematical Modeling, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium. alexander.koch@ugent.be.
authors: Alexander
authors: A
authors: Koch
authors: Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium. tim.demeyer@ugent.be.
authors: Tim
authors: T
authors: De Meyer
authors: Laboratory of Cancer Epigenetics, Université Libre de Bruxelles, Brussels, Belgium. jana.jeschke@ulb.ac.be.
authors: Jana
authors: J
authors: Jeschke
authors: Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium. wim.vancriekinge@ugent.be.
authors: Wim
authors: W
authors: Van Criekinge
mesh_terms: D019295:Computational Biology / Q000379:methods*; D019175:DNA Methylation; D023281:Genomics / Q000379:methods*; D006801:Humans; D012984:Software; D064878:Web Browser