title: [Anti-A/B Antibody Titers in Group O Healthy Donors in Hainan Province Area].
abstract: OBJECTIVE
  To detect the IgM anti-A (B) and IgG anti-A (B) antibody titers of group O healthy donors in Hainan province area, to understand the distribution of O-type blood donor IgM and IgG antibody titers and to analyze the relationship between antibody titers, so as to provide experimental evidences for the safety and feasibility of urgent transfusion of uncrossmatched group O RBCs.
  
  
  METHODS
  Group O whole blood sample was collected from 80 volunteers blood donors. IgM antibody titrations was performed using the immediate spin (IS) tube, and IgG antibody titration were performed using the column agglutination technique with anti-human globulin (AHG). Using two-way ANOVA, paired t-test and correlation analysis, the different types of antibodies were compared.
  
  
  RESULTS
  The IgM antibody titers distributed in 4-1 024, IgG antibody titer distributed in 2-2 048. Anti-A antibody titers of IgG were significantly higher than that of IgM anti-B, IgG anti-B and IgM anti-A titers (P < 0.05). There was a positive correlation bewteen IgM anti-A and anti-B, IgM anti-B and IgG anti-B, IgG anti-A and anti-B (P < 0.05).
  
  
  CONCLUSIONS
  Group O blood donors have high antibody titers in Hainan province area, type O RBC suspensions should be first screened through screening the anti-A titer of IgG, so that can significantly improve the pass rate of O-type universal blood and reduce testing costs.
authors: Department of Blood Transfusion, Hainan Branch of Chinese PLA General Hospital, Sanya 572013, Hainan Province, China.
authors: Shuai
authors: S
authors: Yu
authors: Department of Blood Transfusion, Hainan Branch of Chinese PLA General Hospital, Sanya 572013, Hainan Province, China.
authors: Yong-Wen
authors: YW
authors: Huang
authors: Department of Blood Transfusion, Hainan Branch of Chinese PLA General Hospital, Sanya 572013, Hainan Province, China.
authors: Xiao-Xi
authors: XX
authors: Wang
authors: Department of Blood Transfusion, Hainan Branch of Chinese PLA General Hospital, Sanya 572013, Hainan Province, China.
authors: Yue-Qing
authors: YQ
authors: Wu
authors: Department of Blood Transfusion, Hainan Branch of Chinese PLA General Hospital, Sanya 572013, Hainan Province, China.
authors: Meng-Xia
authors: MX
authors: Lin
authors: Department of Blood Transfusion, Hainan Branch of Chinese PLA General Hospital, Sanya 572013, Hainan Province, China.
authors: Yang
authors: Y
authors: Yu
authors: Department of Blood Transfusion, Hainan Branch of Chinese PLA General Hospital, Sanya 572013, Hainan Province, China. E-mail: luoq66@aliyun.com.
authors: Qun
authors: Q
authors: Luo
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000906:Antibodies; D001782:Blood Donors; D001803:Blood Transfusion; D002681:China; D004912:Erythrocytes; D006801:Humans
chemical_list: D000017:ABO Blood-Group System; D000906:Antibodies