title: [ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS].
abstract: BACKGROUND
  high density lipoproteins (HDL) have important cardiovascular protective effects mediated by their role in reverse cholesterol transport as well as other functional activities, including significant anti-inflammatory and antioxidant properties. It has been shown that HDL anti-inflammatory and antioxidant functions are defective in metabolically stable diabetic patients; however they have not been evaluated during a hyperglycemic crisis.
  
  
  OBJECTIVE
  to determine the antioxidant activity of HDL during a severe diabetic decompensation and to analyze whether this function is restored after resolution of the acute event.
  
  
  METHODS
  the antioxidant activity of HDL was measured in vitro by a fluorescent assay in plasma samples obtained from diabetic patients with acute metabolic decompensation at admission, recovery within the hospital and follow-up in ambulatory care. As a comparison, HDL particles from some healthy subjects were used as controls.
  
  
  RESULTS
  the HDL antioxidant function was significantly reduced in patients during an acute diabetic decompensation compared with the control group, and was gradually restored reaching normal values during the ambulatory follow-up. Hyperglycemic crisis also showed low plasma paraoxonase-1 activity, which increased significantly during at follow-up.
  
  
  CONCLUSIONS
  HDL particles isolated from acute diabetic descompensated patients exhibit a significantly and reversibly low antioxidant capacity, which is probably due to a reduced paraoxonase-1 activity.
authors: Departamento de Nutrición, Diabetes y Metabolismo. Pontificia Universidad Católica de Chile, Santiago. (Chile).. ferawadm@gmail.com.
authors: Fernanda
authors: F
authors: Awad
authors: Departamento de Nutrición, Diabetes y Metabolismo. Pontificia Universidad Católica de Chile, Santiago. (Chile).. SUSANACONTRERASDUARTE@gmail.com.
authors: Susana
authors: S
authors: Contreras-Duarte
authors: Departamento de Nutrición, Diabetes y Metabolismo. Pontificia Universidad Católica de Chile, Santiago. (Chile).. plmolina@uc.cl.
authors: Patricia
authors: P
authors: Molina
authors: Departamento de Nutrición, Diabetes y Metabolismo. Pontificia Universidad Católica de Chile, Santiago. (Chile).. veroqui@med.puc.cl.
authors: Verónica
authors: V
authors: Quiñones
authors: Departamento de Nutrición, Diabetes y Metabolismo. Pontificia Universidad Católica de Chile, Santiago. (Chile).. valenpaz@gmail.com.
authors: Valentina
authors: V
authors: Serrano
authors: Departamento de Medicina Interna. Pontificia Universidad Católica de Chile, Santiago. (Chile).. eabbott3@gmail.com.
authors: Eduardo
authors: E
authors: Abbott
authors: Departamento de Nutrición, Diabetes y Metabolismo. Pontificia Universidad Católica de Chile, Santiago. (Chile).. maiz@med.puc.cl.
authors: Alberto
authors: A
authors: Maiz
authors: Departamento de Nutrición, Diabetes y Metabolismo. Pontificia Universidad Católica de Chile, Santiago. (Chile).. dbusso@med.puc.cl.
authors: Dolores
authors: D
authors: Busso
authors: Departamento de Nutrición, Diabetes y Metabolismo. Centro de Nutrición Molecular y Enfermedades Crónicas. Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago. (Chile).. arigotti@med.puc.cl.
authors: Attilio
authors: A
authors: Rigotti
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers; D001786:Blood Glucose; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress; D012720:Severity of Illness Index
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D008075:Lipoproteins, HDL