title: Transition-Metal-Free Cross-Coupling of Aryl and N-Heteroaryl Cyanides with Benzylic Zinc Reagents.
abstract: Functionalized 4-benzylated pyridines can be efficiently prepared by a transition-metal-free cross-coupling between various benzylic zinc chlorides and substituted 4-cyanopyridines in THF/DMPU under microwave irradiation (40 °C, 0.5-1.5 h). Selective benzylations on polycyano-aromatics have also been achieved under these mild conditions. We also report a novel oxidative nucleophilic substitution of a hydrogen on 1,3-dicyanobenzene using benzylic zinc reagents.
authors: Department Chemie, Ludwig-Maximilians-Universität , Butenandtstrasse. 5-13, 81377 München, Germany.
authors: Pauline
authors: P
authors: Quinio
authors: Department Chemie, Ludwig-Maximilians-Universität , Butenandtstrasse. 5-13, 81377 München, Germany.
authors: Daniela Sustac
authors: DS
authors: Roman
authors: Department Chemie, Ludwig-Maximilians-Universität , Butenandtstrasse. 5-13, 81377 München, Germany.
authors: Thierry
authors: T
authors: León
authors: Department Chemie, Ludwig-Maximilians-Universität , Butenandtstrasse. 5-13, 81377 München, Germany.
authors: Sharankini
authors: S
authors: William
authors: Department Chemie, Ludwig-Maximilians-Universität , Butenandtstrasse. 5-13, 81377 München, Germany.
authors: Konstantin
authors: K
authors: Karaghiosoff
authors: Department Chemie, Ludwig-Maximilians-Universität , Butenandtstrasse. 5-13, 81377 München, Germany.
authors: Paul
authors: P
authors: Knochel