title: 5-HT2A and mGlu2/3 receptor interactions: on their relevance to cognitive function and psychosis.
abstract: Serotonin [5-hydroxytryptamine (5-HT)] and glutamate have both been implicated in the pathophysiology of neuropsychiatric disorders but also in the mechanism of antipsychotic and hallucinogenic drug actions. Furthermore, close antagonistic interactions between 5-HT2A and metabotropic glutamate (mGlu)2/3 receptors have been established over the last decades on the basis of numerous electrophysiological, biochemical, and behavioral studies. Besides synaptic mechanisms, more recent findings suggested that heterodimeric 5-HT2A-mGlu2 receptor complexes in the prefrontal cortex may account for the functional crosstalk between these two receptor subtypes. In this review, we focus on in-vitro and in-vivo studies documenting the important relationship between 5-HT2A and mGlu2/3 receptors, with relevance to both normal behavioral function and psychosis.
authors: Department of Neuropharmacology, Centre for Cognitive Science, Brain Research Institute, University of Bremen, Bremen, Germany.
authors: Lena
authors: L
authors: Wischhof
authors: Michael
authors: M
authors: Koch
mesh_terms: D000818:Animals; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D011618:Psychotic Disorders / Q000188:drug therapy / Q000378:metabolism*; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; C102718:metabotropic glutamate receptor 3