title: Overexpression of Fli-1 is associated with adverse prognosis of endometrial cancer.
abstract: This study aimed to investigate the expression of Friend leukemia virus integration 1 (Fli-1) and its correlation with the prognosis of endometrial cancer (EC). Thirty-two EC tissue samples were evaluated for Fli-1 expression using immunohistochemistry. Fli-1 showed significantly high expression in EC cells, followed by hyperplasia cells, and was negative in adjacent normal tissues. The high expression of Fli-1 was significantly associated with a high differentiation grade, mutated P53 expression, and histological subtype (p < .05). Downregulation of Fli-1 in AN3CN cells using RNA interference inhibited cell clone formation and proliferation but did not affect apoptosis and migration of the cells. This study provides the first evidence that Fli-1 expression gradually increases in parallel with disease progression, and its overexpression might predict poor prognosis in EC.
authors: a Cancer Center, the First Hospital of Jilin University , Changchun , China.
authors: Wei
authors: W
authors: Song
authors: a Cancer Center, the First Hospital of Jilin University , Changchun , China.
authors: Tianyang
authors: T
authors: Zhang
authors: a Cancer Center, the First Hospital of Jilin University , Changchun , China.
authors: Wei
authors: W
authors: Li
authors: b Institute of Basic Medical Sciences , National Center of Biomedical Analysis , Beijing , China.
authors: Rui
authors: R
authors: Mu
authors: c Obstetrics and Gynecology , the Second Hospital of Jilin University , Changchun , China.
authors: Lingyi
authors: L
authors: Zhang
authors: a Cancer Center, the First Hospital of Jilin University , Changchun , China.
authors: Yan
authors: Y
authors: Li
authors: b Institute of Basic Medical Sciences , National Center of Biomedical Analysis , Beijing , China.
authors: Baofeng
authors: B
authors: Jin
authors: b Institute of Basic Medical Sciences , National Center of Biomedical Analysis , Beijing , China.
authors: Na
authors: N
authors: Wang
authors: b Institute of Basic Medical Sciences , National Center of Biomedical Analysis , Beijing , China.
authors: Ailing
authors: A
authors: Li
authors: a Cancer Center, the First Hospital of Jilin University , Changchun , China.
authors: Jiuwei
authors: J
authors: Cui
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D015536:Down-Regulation / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis; D034622:RNA Interference / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D015534:Trans-Activators
chemical_list: C098179:FLII protein, human; D008840:Microfilament Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators
keywords: Endometrial cancer; Fli-1; Prognostic factor; Tumor grade