title: [The role of uric acid in the insulin resistance in children and adolescents with obesity].
abstract: OBJECTIVE
  To investigate the association between serum uric acid levels and insulin resistance in children and adolescents with obesity.
  
  
  METHODS
  Cross-sectional study with 245 children and adolescents (134 obese and 111 controls), aged 8 to 18 years. The anthropometric variables (weight, height and waist circumference), blood pressure and biochemical parameters were collected. The clinical characteristics of the groups were analyzed by t-test or chi-square test. To evaluate the association between uric acid levels and insulin resistance the Pearson's test and logistic regression were applied.
  
  
  RESULTS
  The prevalence of insulin resistance was 26.9%. The anthropometric variables, systolic and diastolic blood pressure and biochemical variables were significantly higher in the obese group (p<0.001), except for the high-density-lipoprotein cholesterol. There was a positive and significant correlation between anthropometric variables and uric acid with HOMA-IR in the obese and in the control groups, which was higher in the obese group and in the total sample. The logistic regression model that included age, gender and obesity, showed an odds ratio of uric acid as a variable associated with insulin resistance of 1.91 (95%CI 1.40 to 2.62; p<-0.001).
  
  
  CONCLUSIONS
  The increase in serum uric acid showed a positive statistical correlation with insulin resistance and it is associated with and increased risk of insulin resistance in obese children and adolescents.
authors: Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil. Electronic address: josiane_miranda21@hotmail.com.
authors: Josiane Aparecida
authors: JA
authors: de Miranda
authors: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors: Guilherme Gomide
authors: GG
authors: Almeida
authors: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors: Raissa Isabelle Leão
authors: RI
authors: Martins
authors: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors: Mariana Botrel
authors: MB
authors: Cunha
authors: Universidade de São Paulo (USP), Ribeirão Preto, SP, Brasil.
authors: Vanessa Almeida
authors: VA
authors: Belo
authors: Universidade de São Paulo (USP), Ribeirão Preto, SP, Brasil.
authors: José Eduardo Tanus
authors: JE
authors: dos Santos
authors: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors: Carlos Alberto
authors: CA
authors: Mourão-Júnior
authors: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors: Carla Márcia Moreira
authors: CM
authors: Lanna
mesh_terms: D000293:Adolescent; D001794:Blood Pressure; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D003430:Cross-Sectional Studies; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D063766:Pediatric Obesity / Q000097:blood* / Q000503:physiopathology; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Childhood obesity; Insulin resistance; Obesidade pediátrica; Resistência à insulina; Uric acid; Ácido úrico