title: [Study on effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids].
abstract: OBJECTIVE
  To investigate the effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids.
  
  
  METHODS
  The in vitro single-pass intestinal perfusion model in rats was established to study the changes in absorption kinetic parameters of dehydrocavidine, berberine hydrochloride and palmatine chloride in C. saxicola total alkaloids after the addition of different concentrations oligochitosan and evaluate the effect of oligochitosan in promoting intestinal absorption of the drugs.
  
  
  RESULTS
  The concentration of oligochitosan had different effects on the absorption rate constant (Ka) and apparent permeability coefficient (Peff) of the three active component in rat intestines. Ka and Peff in 0.5% oligochitosan group significantly increased, indicating a stronger effect in promoting the absorption.
  
  
  CONCLUSIONS
  Oligochitosan has a certain effect in promoting the intestinal absorptions of protoberberine alkaloids in C. saxicola total alkaloids.
authors: Xin-yang
authors: XY
authors: Li
authors: Hui
authors: H
authors: Xie
authors: Tu-lin
authors: TL
authors: Lu
authors: Yue-jiao
authors: YJ
authors: Shi
authors: Xing-de
authors: XD
authors: Zhang
authors: Ting
authors: T
authors: Liu
mesh_terms: D000818:Animals; D001600:Berberine Alkaloids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002686:Chitin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D048271:Chitosan; D031311:Corydalis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008297:Male; D009844:Oligosaccharides; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D009844:Oligosaccharides; C493484:oligochitosan; D002686:Chitin; C009090:protoberberine; D048271:Chitosan