title: Influence of virtual intervention and blood rheology on mass transfer through thoracic aortic aneurysm.
abstract: Computational fluid dynamics tools have been used to investigate blood flow through the human thoracic aortic models with aneurysm before and after virtual stent graft operation. The impact of blood rheology and aortic geometry on the wall shear stress (WSS), luminal surface low-density lipoproteins (LDL) concentration, and oxygen flux along the arterial wall is investigated. The stent graft at the aneurysm has significant effects on WSS and mass transport in blood flow. Due to the low flow rate, Newtonian blood assumption generally under-estimates the WSS. The non-Newtonian blood rheology play an important role in the LDL transport as well as oxygen transport. It is found that WSS alone is insufficient to correctly predict the location with high risk of atherogenesis. The results suggest that WSS, luminal surface LDL concentration, and the oxygen flux on the wall have to be considered together to evaluate the performance of virtual operation.
authors: College of Science, East China Jiaotong University, Nanchang, Jiangxi 330013, China.
authors: Yu
authors: Y
authors: Lei
authors: Orthopedic Department, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China.
authors: Ming
authors: M
authors: Chen
authors: Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York, NY 10065, USA.
authors: Guanglei
authors: G
authors: Xiong
authors: Department of Aerospace Engineering and Engineering Mechanics, University of Cincinnati, Cincinnati, OH 45221, USA. Electronic address: chen06@vt.edu.
authors: Jie
authors: J
authors: Chen
mesh_terms: D001013:Aorta, Thoracic / Q000503:physiopathology*; D017545:Aortic Aneurysm, Thoracic / Q000503:physiopathology* / Q000628:therapy; D050197:Atherosclerosis / Q000503:physiopathology; D001696:Biomechanical Phenomena; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D057446:Hydrodynamics; D008954:Models, Biological; D012039:Regional Blood Flow; D012212:Rheology; D015607:Stents
keywords: Aneurysm; Low-density lipoprotein; Non-Newtonian; Oxygen transport; Stent graft; Wall shear stress