title: Monocyte-Derived Suppressor Cells in Transplantation.
abstract: Myeloid-derived suppressor cells (MDSC) are cells of myeloid origin with enhanced suppressive function. They are negative regulators of the immune responses and comprise a heterogeneous mixture of immunosuppressive cells of monocytic (M-MDSC) and granulocytic (G-MDSC) origin. A more recent nomenclature proposes the term "suppressive monocyte derived cells" (suppressive MCs) to define CSF1/CSF2-dependent mouse suppressor cells that develop from common monocyte progenitors (cMoPs) after birth. Here, we review the literature about monocytic-derived cells with demonstrated suppressor function in vitro and in vivo within the context of solid organ transplantation.
authors: Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
authors: Jordi
authors: J
authors: Ochando
authors: Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
authors: Patricia
authors: P
authors: Conde
authors: Department of Pathology and Diagnostics, Verona University Hospital, Verona, Italy.
authors: Vincenzo
authors: V
authors: Bronte
keywords: Immune regulation; MDSC; Suppressor MCs; Transplantation