title: The autotaxin-lysophosphatidic acid pathway in pathogenesis of rheumatoid arthritis.
abstract: Lysophosphatidic acid (LPA) is a phospholipid that is mainly produced by the hydrolysis of lysophosphatidylcholine (LPC) by lysophospholipase D, which is also called autotaxin (ATX). LPA interacts with specific G-protein coupled receptors and is involved in the regulation of cellular survival, proliferation, differentiation and motility. LPA also has roles in several pathological disorders, such as cancer and pulmonary, dermal and renal fibrosis. The involvement of the ATX-LPA pathway has recently been demonstrated in inflammatory responses and apoptosis of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis and during the development of experimental arthritis. This review summarises the current literature of the ATX-LPA pathway in rheumatoid arthritis.
authors: Laboratorio de Reumatología Experimental (n°8), Instituto de Investigación Sanitaria de Santiago (IDIS) , Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), Servicio Gallego de Salud (SERGAS), Travesia da Choupana s/n, Santiago de Compostela 15706, Spain.
authors: Beatriz
authors: B
authors: Orosa
authors: Laboratorio de Reumatología Experimental (n°8), Instituto de Investigación Sanitaria de Santiago (IDIS) , Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), Servicio Gallego de Salud (SERGAS), Travesia da Choupana s/n, Santiago de Compostela 15706, Spain.
authors: Samuel
authors: S
authors: García
authors: Laboratorio de Reumatología Experimental (n°8), Instituto de Investigación Sanitaria de Santiago (IDIS) , Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), Servicio Gallego de Salud (SERGAS), Travesia da Choupana s/n, Santiago de Compostela 15706, Spain. Electronic address: Carmen.Conde.Muro@sergas.es.
authors: Carmen
authors: C
authors: Conde
mesh_terms: D000818:Animals; D017209:Apoptosis; D001169:Arthritis, Experimental / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008246:Lysophospholipids / Q000276:immunology / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000276:immunology / Q000378:metabolism*; D049368:Receptors, Lysophosphatidic Acid / Q000378:metabolism*; D015398:Signal Transduction; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology; D000099189:Lysophospholipase D
chemical_list: D008246:Lysophospholipids; D010727:Phosphoric Diester Hydrolases; D049368:Receptors, Lysophosphatidic Acid; D000099189:Lysophospholipase D; C032881:lysophosphatidic acid
keywords: Autotaxin; Experimental arthritis; Inflammatory response; Lysophosphatidic acid; Rheumatoid arthritis; fibroblast like; ibroblast‐like