title: Continuation versus discontinuation of oxytocin infusion during the active phase of labour: a randomised controlled trial.
abstract: OBJECTIVE
  To investigate whether discontinuation of oxytocin infusion increases the duration of the active phase of labour and reduces maternal and neonatal complications.
  
  
  METHODS
  Randomised controlled trial.
  
  
  METHODS
  Department of Obstetrics and Gynaecology, Regional Hospital of Randers, Denmark.
  
  
  METHODS
  Women with singleton pregnancy in the vertex position undergoing labour induction or augmentation.
  
  
  METHODS
  Two hundred women were randomised when cervical dilation was ≤4 cm to either continue or discontinue oxytocin infusion when cervical dilation reached 5 cm.
  
  
  METHODS
  The primary outcome was duration of the active phase of labour, defined as the time period from 5 cm of cervical dilation until delivery. Secondary outcomes were mode of delivery, uterine tachysystole, hyperstimulation, abnormalities in fetal heart rate, postpartum haemorrhage rate, perineal tears, and neonatal outcomes.
  
  
  RESULTS
  The active phase of labour was longer by 41 minutes (95% confidence interval 11-75 minutes) in the discontinued group (median 125 minutes in 85 women who had reached the active phase and delivered vaginally) versus the continued group (median 88 minutes in 78 women). The incidence of fetal heart rate abnormalities (51 versus 20%) and uterine hyperstimulation (12 versus 2%) was significantly greater in the continued than the discontinued oxytocin group. The incidence of tachysystole, caesarean deliveries, postpartum haemorrhage, third degree perineal tears and adverse neonatal outcomes was higher in the continued group, but did not reach significance.
  
  
  CONCLUSIONS
  Discontinuation of oxytocin infusion in the active phase of labour may improve some labour outcomes but has the disadvantage of increasing the duration of the active phase of labour.
  
  
  CONCLUSIONS
  Stopping oxytocin in the active phase seems to make labour less complicated but lengthens duration.
authors: Department of Obstetrics and Gynaecology, Regional Hospital of Randers, Randers, Denmark.
authors: P
authors: P
authors: Bor
authors: Department of Obstetrics and Gynaecology, Regional Hospital of Randers, Randers, Denmark.
authors: S
authors: S
authors: Ledertoug
authors: Department of Obstetrics and Gynaecology, Regional Hospital of Randers, Randers, Denmark.
authors: S
authors: S
authors: Boie
authors: Department of Obstetrics and Gynaecology, Regional Hospital of Randers, Randers, Denmark.
authors: N O
authors: NO
authors: Knoblauch
authors: Department of Obstetrics and Gynaecology, Regional Hospital of Randers, Randers, Denmark.
authors: I
authors: I
authors: Stornes
mesh_terms: D000328:Adult; D036861:Delivery, Obstetric / Q000379:methods; D003718:Denmark / Q000453:epidemiology; D004334:Drug Administration Schedule; D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007745:Labor Onset / Q000187:drug effects*; D007751:Labor, Induced / Q000379:methods*; D010120:Oxytocics / Q000008:administration & dosage*; D010121:Oxytocin / Q000008:administration & dosage*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods*
chemical_list: D010120:Oxytocics; D010121:Oxytocin
keywords: Active phase of labour; caesarean delivery; discontinuation of oxytocin; fetal heart rate abnormalities; hyperstimulation