title: Treatment of Local Anesthetic-Induced Cardiotoxicity Using Drug Scavenging Nanoparticles.
abstract: Because of its ability to create structures of nanoscale dimension with large aggregate particle surface area-to-volume ratios, nanotechnology offers new opportunities to treat drug poisonings. Emulsion-based nanoparticles (diameter: 118.4 nm) extracted bupivacaine from the aqueous phase in a physiological salt solution and attenuated the drug's cardiotoxicity in guinea pig heart to a greater extent than did a macroemulsion (432.0 nm). Additionally, nanoparticles sequestered bupivacaine from the aqueous phase of human blood and merit further investigation in animal models of intoxication.
authors: Departments of Anesthesiology and Chemical Engineering, Particle Engineering Research Center, University of Florida, Gainesville, Florida 32610-0254.
authors: Timothy E
authors: TE
authors: Morey
authors: Departments of Anesthesiology and Chemical Engineering, Particle Engineering Research Center, University of Florida, Gainesville, Florida 32610-0254.
authors: Manoj
authors: M
authors: Varshney
authors: Departments of Anesthesiology and Chemical Engineering, Particle Engineering Research Center, University of Florida, Gainesville, Florida 32610-0254.
authors: Jason A
authors: JA
authors: Flint
authors: Departments of Anesthesiology and Chemical Engineering, Particle Engineering Research Center, University of Florida, Gainesville, Florida 32610-0254.
authors: Surender
authors: S
authors: Rajasekaran
authors: Departments of Anesthesiology and Chemical Engineering, Particle Engineering Research Center, University of Florida, Gainesville, Florida 32610-0254.
authors: Dinesh O
authors: DO
authors: Shah
authors: Departments of Anesthesiology and Chemical Engineering, Particle Engineering Research Center, University of Florida, Gainesville, Florida 32610-0254.
authors: Donn M
authors: DM
authors: Dennis