title: Prevention of Recurrent Staphylococcal Skin Infections.
abstract: Staphylococcus aureus infections pose a significant health burden. The emergence of community-associated methicillin-resistant S aureus has resulted in an epidemic of skin and soft tissue infections (SSTI), and many patients experience recurrent SSTI. As S aureus colonization is associated with subsequent infection, decolonization is recommended for patients with recurrent SSTI or in settings of ongoing transmission. S aureus infections often cluster within households, and asymptomatic carriers serve as reservoirs for transmission; therefore, a household approach to decolonization is more effective than measures performed by individuals alone. Novel strategies for the prevention of recurrent SSTI are needed.
authors: Vanderbilt Vaccine Research Program, Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell, Jr. Children's Hospital at Vanderbilt, S2323 MCN, 1161 21st Avenue South, Nashville, TN 37232, USA.
authors: C Buddy
authors: CB
authors: Creech
authors: Department of Pediatrics, Children's Mercy Hospital Infection Prevention and Control, University of Missouri-Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA.
authors: Duha N
authors: DN
authors: Al-Zubeidi
authors: Division of Pediatric Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8116, St Louis, MO 63110, USA. Electronic address: fritz_s@kids.wustl.edu.
authors: Stephanie A
authors: SA
authors: Fritz
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002353:Carrier State / Q000382:microbiology*; D017714:Community-Acquired Infections / Q000382:microbiology / Q000517:prevention & control / Q000628:therapy; D005191:Family Characteristics; D005260:Female; D006801:Humans; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000254:growth & development; D012008:Recurrence; D012307:Risk Factors; D013207:Staphylococcal Skin Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control* / Q000635:transmission; D013211:Staphylococcus aureus / Q000254:growth & development*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Decolonization; MRSA; Pediatrics; Prevention; Skin infection; Staphylococcal vaccine; Staphylococcus aureus