title: [Changes in Appetite, Nutrition, and Oxidative Stress Reaction of Cancer Patients during Chemotherapy].
abstract: Weight loss during chemotherapy is a result of malnutrition and metabolism abnormality. A few reports have focused on the treatment and prevention of weight and appetite loss in patients with advanced cancer. We evaluated the relationship between weight and appetite loss during chemotherapy by studying the meal intake of patients. In addition, we also investigated whether anorexia is associated with the level of 8-hydroxy-2' -deoxyguanosine (8-OHdG), an oxidation stress marker. The weight loss rate in patients who lack energy intake was significantly higher than that in patients with adequate energy intake. Moreover, the pre-chemotherapy total energy intake, measured according to the hospital meal consumption of patients, was lower among those with than among those without anorexia. The 8-OHdG levels in the patients with anorexia were significantly higher. In conclusion, nutritional management is important for patients even before chemotherapy is started. The 8-OHdG level can be used as an index to evaluate appetite.
authors: Health Service Center, Hiroshima University.
authors: Nao
authors: N
authors: Aoyama
authors: Sanae
authors: S
authors: Asano
authors: Miho
authors: M
authors: Shingu
authors: Kazumi
authors: K
authors: Ueno
authors: Mika
authors: M
authors: Miyashita
authors: Hironobu
authors: H
authors: Hamada
authors: Hiroshi
authors: H
authors: Aikata
authors: Tsuyoshi
authors: T
authors: Kataoka
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001066:Appetite / Q000187:drug effects*; D001661:Biliary Tract Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D018384:Oxidative Stress / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents