title: Prevalence of Prediabetes Based on Fasting Plasma Glucose and Glycosylated Hemoglobin in an At-Risk Mexican Population.
abstract: BACKGROUND
  In Latin America, there are no published studies of the prevalence of prediabetes using the glycosylated hemoglobin (HbA1c) criterion in addition to fasting plasma glucose (FPG). Therefore, here we determined the prevalence of prediabetes using FPG and/or HbA1c in a Mexican population at risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease.
  
  
  METHODS
  This cross-sectional study included 384 primary care users without a known diagnosis of prediabetes or T2DM and with at least one risk factor for T2DM and cardiovascular disease. An FPG 100-125 mg/dL and/or an HbA1c 5.7-6.4% were considered positive for prediabetes. Point prevalence and 95% confidence intervals (CI) were estimated overall and stratified by age, sex, and nutritional status. Mann-Whitney and chi-squared tests were used. P values < 0.05 were considered significant.
  
  
  RESULTS
  The prevalence of prediabetes was 74.7% (95% CI, 70.2%-78.8%) using FPG or HbA1c criteria for positivity, 60.4% using FPG alone (95% CI, 55.5%-65.3%), 49.8% using HbA1c alone (95% CI, 44.4-55.3%); and 32.9% using FPG and HbA1c (95% CI, 27.8%-38.0%). Prevalence was higher in patients ≥50 years old (p < 0.001) and in the overweight-obesity group (p = 0.04) using all criteria except for HbA1c alone.
  
  
  CONCLUSIONS
  The prevalence of prediabetes in a Mexican population at risk for cardiovascular disease and/or T2DM was high. Prediabetes is definitely a public health problem. Future studies are needed to examine the effectiveness and efficiency of pragmatic strategies to reverse the status of prediabetes and, therefore, reduce the incidence of T2DM.
authors: 1 Unidad de Medicina Familiar No. 31, Instituto Mexicano del Seguro Social , San Nicolás de los Garza, Mexico .
authors: Lorena Guadalupe
authors: LG
authors: Villanueva-Sosa
authors: 1 Unidad de Medicina Familiar No. 31, Instituto Mexicano del Seguro Social , San Nicolás de los Garza, Mexico .
authors: Hid Felizardo
authors: HF
authors: Cordero-Franco
authors: 2 Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social , Monterrey, Mexico .|3 Universidad Autónoma de Nuevo León , Facultad de Salud Pública y Nutrición, Monterrey, Mexico .
authors: Ana María
authors: AM
authors: Salinas-Martínez
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology; D005215:Fasting / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood* / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin