title: Mitochondrial Transcription Factor A and Mitochondrial Genome as Molecular Targets for Cisplatin-Based Cancer Chemotherapy.
abstract: Mitochondria are important cellular organelles that function as control centers of the energy supply for highly proliferative cancer cells and regulate apoptosis after cancer chemotherapy. Cisplatin is one of the most important chemotherapeutic agents and a key drug in therapeutic regimens for a broad range of solid tumors. Cisplatin may directly interact with mitochondria, which can induce apoptosis. The direct interactions between cisplatin and mitochondria may account for our understanding of the clinical activity of cisplatin and development of resistance. However, the basis for the roles of mitochondria under treatment with chemotherapy is poorly understood. In this review, we present novel aspects regarding the unique characteristics of the mitochondrial genome in relation to the use of platinum-based chemotherapy and describe our recent work demonstrating the importance of the mitochondrial transcription factor A (mtTFA) expression in cancer cells.
authors: Asahi Matsumoto Hospital, Kokuramimami-ku Tsuda, Kitakyushu-shi 800-0242, Japan. k-kohno@med.uoeh-u.ac.jp.
authors: Kimitoshi
authors: K
authors: Kohno
authors: Shared-Use Research Center, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan. kywang@med.uoeh-u.ac.jp.
authors: Ke-Yong
authors: KY
authors: Wang
authors: Department of Neurosurgery, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan. maytak@med.uoeh-u.ac.jp.
authors: Mayu
authors: M
authors: Takahashi
authors: Department of Gynecology, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan. t-kurita@med.uoeh-u.ac.jp.
authors: Tomoko
authors: T
authors: Kurita
authors: Department of Gastroenterological Surgery, School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan. yy4160@yahoo.co.jp.
authors: Yoichiro
authors: Y
authors: Yoshida
authors: Department of Radiology, Beppu Hospital, Kyushu University, Beppu 874-0838, Japan. hirakawa@beppu.kyushu-u.ac.jp.
authors: Masakazu
authors: M
authors: Hirakawa
authors: Department of Pathology and Cell Biology, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan. y8harada@gmail.com.
authors: Yoshikazu
authors: Y
authors: Harada
authors: Second Department of Internal Medicine, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan. akihiro_k@me.com.
authors: Akihiro
authors: A
authors: Kuma
authors: Department of Occupational Pneumology, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan. h-izumi@med.uoeh-u.ac.jp.
authors: Hiroto
authors: H
authors: Izumi
authors: Asahi Matsumoto Hospital, Kokuramimami-ku Tsuda, Kitakyushu-shi 800-0242, Japan. sm.kokura.1949@docomo.ne.jp.
authors: Shinji
authors: S
authors: Matsumoto
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002945:Cisplatin / Q000494:pharmacology* / Q000627:therapeutic use; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D054629:Genome, Mitochondrial / Q000187:drug effects*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects; D024101:Mitochondrial Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D018384:Oxidative Stress; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D024101:Mitochondrial Proteins; D014157:Transcription Factors; C422562:mitochondrial transcription factor A; D002945:Cisplatin
keywords: cancer chemotherapy; cisplatin; mtDNA; mtTFA; prognosis