title: Genetic Knowledge Among Participants in the Coriell Personalized Medicine Collaborative.
abstract: Genetic literacy is essential for the effective integration of genomic information into healthcare; yet few recent studies have been conducted to assess the current state of this knowledge base. Participants in the Coriell Personalized Medicine Collaborative (CPMC), a prospective study assessing the impact of personalized genetic risk reports for complex diseases and drug response on behavior and health outcomes, completed genetic knowledge questionnaires and other surveys through an online portal. To assess the association between genetic knowledge and genetic education background, multivariate linear regression was performed. 4 062 participants completed a genetic knowledge and genetic education background questionnaire. Most were older (mean age: 50), Caucasian (90 %), female (59 %), highly educated (69 % bachelor's or higher), with annual household income over $100 000 (49 %). Mean percent correct was 76 %. Controlling for demographics revealed that health care providers, participants previously exposed to genetics, and participants with 'better than most' self-rated knowledge were significantly more likely to have a higher knowledge score (p < 0.001). Overall, genetic knowledge was high with previous genetic education experience predictive of higher genetic knowledge score. Education is likely to improve genetic literacy, an important component to expanded use of genomics in personalized medicine.
authors: Coriell Institute for Medical Research, 403 Haddon Avenue, Camden, NJ, 08103, USA. tschmidlen@coriell.org.
authors: Tara J
authors: TJ
authors: Schmidlen
authors: Coriell Institute for Medical Research, 403 Haddon Avenue, Camden, NJ, 08103, USA.
authors: Laura
authors: L
authors: Scheinfeldt
authors: Coriell Institute for Medical Research, 403 Haddon Avenue, Camden, NJ, 08103, USA.
authors: Ruixue
authors: R
authors: Zhaoyang
authors: Coriell Institute for Medical Research, 403 Haddon Avenue, Camden, NJ, 08103, USA.
authors: Rachel
authors: R
authors: Kasper
authors: Ohio State University, Columbus, OH, USA.
authors: Kevin
authors: K
authors: Sweet
authors: 23andMe, Mountain View, CA, USA.
authors: Erynn S
authors: ES
authors: Gordon
authors: American Red Cross, Philadelphia, PA, USA.
authors: Margaret
authors: M
authors: Keller
authors: Annals of Internal Medicine, Philadelphia, PA, USA.
authors: Cathy
authors: C
authors: Stack
authors: Coriell Institute for Medical Research, 403 Haddon Avenue, Camden, NJ, 08103, USA.
authors: Neda
authors: N
authors: Gharani
authors: Temple Health, Fox Chase Cancer Center, Philadelphia, PA, USA.
authors: Mary B
authors: MB
authors: Daly
authors: Coriell Institute for Medical Research, 403 Haddon Avenue, Camden, NJ, 08103, USA.
authors: Joseph
authors: J
authors: Jarvis
authors: Coriell Institute for Medical Research, 403 Haddon Avenue, Camden, NJ, 08103, USA.
authors: Michael F
authors: MF
authors: Christman
mesh_terms: D000328:Adult; D000368:Aged; D002983:Clinical Competence; D015331:Cohort Studies; D003299:Cooperative Behavior; D005260:Female; D005823:Genetics / Q000193:education*; D057220:Health Literacy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D057285:Precision Medicine; D011446:Prospective Studies; D011795:Surveys and Questionnaires
keywords: Education; Genetic knowledge; Genetic literacy; Health literacy; Personalized medicine