title: Impact of maternal bifidobacteria and the mode of delivery on Bifidobacterium microbiota in infants.
abstract: The aim of this study is to examine the influence of maternal intestinal and vaginal bifidobacteria on the colonisation of bifidobacteria in the gut of infants. Faecal samples from 120 healthy pregnant mothers within 1 month of delivery and from their infants at 1 month of age and 98 vaginal swabs from the mothers at the time of delivery were collected at a maternity hospital in Chiang Mai, Thailand. The faecal and vaginal samples were assayed by real-time PCR assays to detect Bifidobacterium species and to estimate the bifidobacterial copy numbers. After adjusting for the numbers of each Bifidobacterium species, delivery mode, and antibiotic use in infants by the age of 1 month, total counts of bifidobacteria in the mothers' faeces were associated with increased copy numbers of bifidobacteria in the faeces of breastfed infants. A caesarean section was also significantly associated with a decrease in the copy numbers of bifidobacteria in the faeces of infants. No significant correlation was found between the bifidobacterial copies of the vaginal swabs and those of the infants' faeces. The intestinal bifidobacterial status of exclusively breastfed infants was significantly positive affected by vaginal delivery and high bifidobacterial copy numbers in their mothers' gut.
authors: 1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Suthep road, Suthep, Muang, 50200 Chiang Mai, Thailand.
authors: S
authors: S
authors: Sirilun
authors: 2 Laboratory for Infectious Diseases, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors: H
authors: H
authors: Takahashi
authors: 3 Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Suthep road, Suthep, Muang, 50200 Chiang Mai, Thailand.
authors: S
authors: S
authors: Boonyaritichaikij
authors: 1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Suthep road, Suthep, Muang, 50200 Chiang Mai, Thailand.
authors: C
authors: C
authors: Chaiyasut
authors: 4 Chiang Mai Health Promotion Hospital, Health Center Region 10th, Prachasamphan road, Changklan, Muang, 50100 Chiang Mai, Thailand.
authors: P
authors: P
authors: Lertruangpanya
authors: 2 Laboratory for Infectious Diseases, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors: Y
authors: Y
authors: Koga
authors: 2 Laboratory for Infectious Diseases, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.|5 Department of Psychiatry, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors: K
authors: K
authors: Mikami
mesh_terms: D058491:Bacterial Load; D001644:Bifidobacterium / Q000145:classification / Q000302:isolation & purification*; D001942:Breast Feeding; D036861:Delivery, Obstetric; D005243:Feces / Q000382:microbiology; D005260:Female; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D064307:Microbiota; D011247:Pregnancy; D013785:Thailand; D014621:Vagina / Q000382:microbiology*
keywords: Bifidobacterium; gut; infant; microbiota; mother