title: Altered cognitive processes in the acute phase of mTBI: an analysis of independent components of event-related potentials.
abstract: Mild traumatic brain injuries (mTBI) generate acute disruptions of brain function and a subset of patients shows persisting cognitive, affective, and somatic symptoms. Deficits in the executive function domain are among the more frequent cognitive impairments reported by mTBI patients. By means of independent component analysis, event-related potential components from a visual cued go/nogo task, namely contingent negative variation (CNV) and NoGo-P3, were decomposed into distinct independent components that have been shown to be associated with the executive processes of energization, monitoring, and task setting. A group of symptomatic mTBI patients was compared with a group of controls matched for sex, age, and education. Patients showed reduced amplitudes in the late CNV as well as in the early NoGo-P3 subcomponents. Whereas the decreased CNVlate component indicates an impaired ability to generate representations of stimulus-response associations and to energize the maintenance of response patterns, the reduced P3NOGOearly component suggests a deficient ability to invest attentional effort in the initiation of response patterns in mTBI patients. Besides indicating the effects of mTBI on cognitive brain processing, the results may open up the possibility for assessing individual mTBI profiles and facilitate personalized rehabilitative measures.
authors: aBrain and Trauma Foundation Grisons, Chur bClinic of Rehabilitation Bellikon, Bellikon cDepartment of Psychology, Division Neuropsychology, University of Zurich dDivision of Trauma Surgery eInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich fDepartment of Surgery, Waid City Hospital, Zurich Departments of gTraumatology hNeurosurgery, Cantonal Hospital Aarau, Aarau iInterdisciplinary Emergency Centre, Baden Cantonal Hospital, Baden, Switzerland.
authors: Andreas
authors: A
authors: Müller
authors: Gian
authors: G
authors: Candrian
authors: Patrizia
authors: P
authors: Dall'Acqua
authors: Kyveli
authors: K
authors: Kompatsiari
authors: Gian-Marco
authors: GM
authors: Baschera
authors: Ladislav
authors: L
authors: Mica
authors: Hans-Peter
authors: HP
authors: Simmen
authors: Richard
authors: R
authors: Glaab
authors: Javier
authors: J
authors: Fandino
authors: Markus
authors: M
authors: Schwendinger
authors: Christoph
authors: C
authors: Meier
authors: Erika Jasmin
authors: EJ
authors: Ulbrich
authors: Sönke
authors: S
authors: Johannes
mesh_terms: D000208:Acute Disease; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology* / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology*