title: Association of Chemotactic Chemokine Ligand 5 Polymorphisms with the Risk of Developing Severe Enterovirus 71 Infection.
abstract: Respiratory damage is a main manifestation of severe Enterovirus 71 (EV71) infection. Polymorphisms of -403G/A (rs2107538), -28C/G (rs2280788), and In1.1T/C (rs2280789) in chemotactic chemokine ligand 5 (CCL5) have linked with many respiratory diseases. In this study, we explored the possible correlation of CCL5 polymorphisms with severe EV71 infection. Blood samples were obtained from 87 children hospitalized for EV71 infection. Fifty-seven healthy children were enrolled as asymptomatic controls. Genotype and allele frequencies were analyzed by logistic regression analysis. There were statistically significant differences in polymorphisms of CCL5 -403G/A and In1.1T/C for dominant model (P = 0.016; P = 0.027) and additive model (P = 0.010; P = 0.019) between patients with severe EV71 infection and asymptomatic controls. With ordinal logistic regression model analysis, statistically significant differences were found between polymorphisms of CCL5 (-403G/A) (P = 0.034) with the severity of EV71 infection after adjusting for age. The frequency of A-C-C haplotype was significantly higher in EV71 infection patients than controls (P = 0.032). These results suggest that CCL5 -403G/A and In1.1T/C polymorphisms may contribute to severe EV71 infection and individuals with haplotype of A-C-C may exhibit higher risk of developing severe EV71 infection. These findings may provide insights into pathogenic and protective mechanisms of severe EV71 infection.
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China.
authors: Mao-Zhong
authors: MZ
authors: Li
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China.
authors: Li-Li
authors: LL
authors: Pang
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China.
authors: Ai-Ying
authors: AY
authors: Bai
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China.
authors: Shi-Cheng
authors: SC
authors: Yu
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China.
authors: Xun
authors: X
authors: Gong
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China.
authors: Na
authors: N
authors: Liu
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China.
authors: Kun
authors: K
authors: Cai
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China.
authors: Guang-Cheng
authors: GC
authors: Xie
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China.
authors: Wen-Juan
authors: WJ
authors: Gao
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China zhaojund@126.com jinyuldyy@163.com.
authors: Yu
authors: Y
authors: Jin
authors: National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China; Ji'nan Municipal Center for Disease Control and Prevention, Ji'nan, China; National Center for Public Health Surveillance and Information Services, Chinese Center for Disease Control and Prevention, Beijing, China; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing, China zhaojund@126.com jinyuldyy@163.com.
authors: Zhao-Jun
authors: ZJ
authors: Duan
mesh_terms: D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D002675:Child, Preschool; D029821:Enterovirus A, Human; D004769:Enterovirus Infections / Q000235:genetics* / Q000821:virology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5