title: Citrate Formulation Determines Filter Lifespan during Continuous Veno-Venous Hemofiltration: A Prospective Cohort Study.
abstract: BACKGROUND
  We conducted an 8-month prospective single-center observational study in patients with acute kidney injury treated with continuous veno-venous hemofiltration (CVVH) to compare the impact of two citrate formulations on filter lifespan (FLS).
  
  
  METHODS
  Patients received CVVH at a delivered dose of 25 ml/kg/h. Multivariable linear regression was performed to assess the influence of different variables on circuit lifespan.
  
  
  RESULTS
  We included 59 patients, 28 received the 10/2 formulation and 31 received the 18/0 formulation. Median (interquartile range) FLS was significantly prolonged with the 18/0 solution compared with the 10/2 solution (4.10 (2.45-5.75) vs. 2.68 (0.47-4.99) days, p = 0.001). No confounding variables (difference in ionized calcium target, citrate flow or dose, platelet count, hematocrit, vascular access location) affecting filter capacity or lifespan between the 2 formulations were identified.
  
  
  CONCLUSIONS
  Under similar conditions of CVVH and calcium targets, a Prismocitrate 18/0 formulation significantly improved FLS as compared with Prismocitrate 10/2.
authors: Intensive Care Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
authors: Rita
authors: R
authors: Jacobs
authors: Patrick M
authors: PM
authors: Honoré
authors: Sean M
authors: SM
authors: Bagshaw
authors: Marc
authors: M
authors: Diltoer
authors: Herbert D
authors: HD
authors: Spapen
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology / Q000628:therapy*; D000368:Aged; D000369:Aged, 80 and over; D002951:Citrates / Q000737:chemistry*; D005260:Female; D006400:Hematocrit; D015312:Hemodialysis Solutions / Q000737:chemistry*; D006440:Hemofiltration / Q000295:instrumentation*; D018056:Hemorheology; D006801:Humans; D007688:Kidneys, Artificial; D016014:Linear Models; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D008875:Middle Aged; D010976:Platelet Count; D011446:Prospective Studies
chemical_list: D002951:Citrates; D015312:Hemodialysis Solutions; D008567:Membranes, Artificial