title: A Reversible Photoacid Functioning in PBS Buffer under Visible Light.
abstract: A metastable-state photoacid that can reversibly release a proton in PBS buffer (pH = 7.4) under visible light is reported. The design is based on the dual acid-base property and tautomerization of indazole. The quantum yield was as high as 0.73, and moderate light intensity (10(2) μmol·m(2)·s(-1)) is sufficient for the photoreaction. Reversible pH change of 1.7 units was demonstrated using a 0.1 mM aqueous solution. This type of photoacid is promising for control of proton-transfer processes in physiological conditions and may find applications in biomedical areas.
authors: Department of Chemistry, Florida Institute of Technology , Melbourne, Florida 32901, United States.
authors: Nawodi
authors: N
authors: Abeyrathna
authors: Department of Chemistry, Florida Institute of Technology , Melbourne, Florida 32901, United States.
authors: Yi
authors: Y
authors: Liao
mesh_terms: D000818:Animals; D002021:Buffers; D006863:Hydrogen-Ion Concentration; D007191:Indazoles / Q000737:chemistry; D008027:Light; D055668:Photochemical Processes
chemical_list: D002021:Buffers; D007191:Indazoles