title: Mantle cell lymphoma--a spectrum from indolent to aggressive disease.
abstract: Mantle cell lymphoma (MCL) is a distinctive lymphoma type generally characterized by the presence of CCND1 translocation and overexpression of cyclin D1. MCL usually presents with advanced stage and rapid clinical progression. The diagnosis is in most instances uncomplicated but cases with variant morphologies or immunophenotypes, especially cyclin D1-negative cases, may cause diagnostic difficulties. During the mantle cell lymphoma (MCL) session at the European Association of Haematopathology/Society for Hematopathology workshop 2014 held in Istanbul, Turkey, submitted cases illustrated interesting features such as unusual morphology or immunophenotypes. In several submitted cases of cyclin D1-positive MCL, CCND1 rearrangement could not be detected by t(11;14)(q13;q32) dual-color dual-fusion FISH but was suggested by CCND1 break-apart probes, and advantages and disadvantages of different FISH probes were highlighted. Three cyclin D1-negative MCL cases were submitted. These were identified by SOX11 immunohistochemistry and found to carry CCND2 translocations and/or to express high levels of cyclin D2 mRNA. Features associated with aggressive clinical course were presented including high expression of p53 protein and MYC aberrations. The need to integrate histological, immunophenotypic, genetic, and clinical data to arrive at the correct diagnosis was emphasized.
authors: Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, SE 141 86, Stockholm, Sweden. birgitta.sander@ki.se.
authors: Birgitta
authors: B
authors: Sander
authors: Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.
authors: Leticia
authors: L
authors: Quintanilla-Martinez
authors: Department of Clinical Pathology, Robert-Bosch-Hospital and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
authors: German
authors: G
authors: Ott
authors: Department of Bio-Pathology, Institut Paoli-Calmettes, Marseille, France.
authors: Luc
authors: L
authors: Xerri
authors: Department of Pathology, Ankara University School of Medicine, Sihhiye, Ankara, Turkey.
authors: Isinsu
authors: I
authors: Kuzu
authors: Queen Elizabeth Hospital, Hong Kong, SAR, China.
authors: John K C
authors: JK
authors: Chan
authors: Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors: Steven H
authors: SH
authors: Swerdlow
authors: Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors: Elias
authors: E
authors: Campo
mesh_terms: D000818:Animals; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D016130:Immunophenotyping / Q000379:methods; D017404:In Situ Hybridization, Fluorescence; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D020522:Lymphoma, Mantle-Cell / Q000473:pathology*; D014178:Translocation, Genetic / Q000235:genetics*
keywords: Aggressive; FISH; Genetic aberrations; Immunophenotype; Indolent; Mantle cell lymphoma; Morphology