title: NSAIDs in paediatrics: caution with varicella!
abstract: Anti-inflammatory drugs have been suspected on several occasions to have promoted development of bacterial infection among varicella patients. Some countries have not implemented childhood varicella vaccination. Three cases in our hospital suggested the predisposing role of NSAIDs in varicella patient deterioration. Open access to these drugs widely increases their use and patient information should be continually provided in the medical offices and at dispensing pharmacy counters. Taking account of the benefit/risk balance and applying the simple precautionary principle, it would be appropriate to be cautious about the use of NSAIDs in the paediatric population.
authors: Pharmacie, Hôpital Robert-Debré, APHP, 48 bd Sérurier, 75019, Paris, France.|Pharmacie Clinique, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors: L
authors: L
authors: Durand
authors: Réanimation pédiatrique, Hôpital Robert-Debré, APHP, Paris, France.
authors: P
authors: P
authors: Sachs
authors: Pédiatrie Générale, Hôpital Robert-Debré, APHP, Paris, France.
authors: C
authors: C
authors: Lemaitre
authors: Pédiatrie Générale, Hôpital Robert-Debré, APHP, Paris, France.
authors: M
authors: M
authors: Lorrot
authors: Service de Pharmacologie Pédiatrique et Pharmacogénétique, Hôpital Robert-Debré, APHP, Paris, France.
authors: J
authors: J
authors: Bassehila
authors: Pharmacie, Hôpital Robert-Debré, APHP, 48 bd Sérurier, 75019, Paris, France.|Pharmacie Clinique, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|Laboratoire Educations et Pratiques de Santé, EA 3412, Université Paris 13, Sorbonne Paris Cité, Bobigny, France.
authors: O
authors: O
authors: Bourdon
authors: Pharmacie, Hôpital Robert-Debré, APHP, 48 bd Sérurier, 75019, Paris, France. sonia.prot-labarthe@aphp.fr.|Pharmacie Clinique, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. sonia.prot-labarthe@aphp.fr.|INSERM, ECEVE U1123, Paris, France. sonia.prot-labarthe@aphp.fr.
authors: S
authors: S
authors: Prot-Labarthe
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002644:Chickenpox / Q000150:complications*; D002648:Child; D006801:Humans; D010372:Pediatrics
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Bacterial complications; Children; Ibuprofen; Infection; NSAIDs; Paediatrics; Varicella