title: The neuronal identity bias behind neocortical GABAergic plasticity.
abstract: In the neocortex, different types of excitatory and inhibitory neurons connect to one another following a detailed blueprint, defining functionally-distinct subnetworks, whose activity and modulation underlie complex cognitive functions. We review the cell-autonomous plasticity of perisomatic inhibition onto principal excitatory neurons. We propose that the tendency of different cortical layers to exhibit depression or potentiation of perisomatic inhibition is dictated by the specific identities of principal neurons (PNs). These are mainly defined by their projection targets and by their preference to be innervated by specific perisomatic-targeting basket cell types. Therefore, principal neurons responsible for relaying information to subcortical nuclei are differentially inhibited and show specific forms of plasticity compared to other PNs that are specialized in more associative functions.
authors: Sorbonne Universités, Université Pierre et Marie Curie (UPMC Paris 6), Unité Mixte de Recherche S 1127; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1127; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 7225; Institut du Cerveau et de la Moelle épinière (ICM), 75013 Paris, France.
authors: Camille
authors: C
authors: Allene
authors: Sorbonne Universités, Université Pierre et Marie Curie (UPMC Paris 6), Unité Mixte de Recherche S 1127; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1127; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 7225; Institut du Cerveau et de la Moelle épinière (ICM), 75013 Paris, France.
authors: Joana
authors: J
authors: Lourenço
authors: Sorbonne Universités, Université Pierre et Marie Curie (UPMC Paris 6), Unité Mixte de Recherche S 1127; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1127; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 7225; Institut du Cerveau et de la Moelle épinière (ICM), 75013 Paris, France. Electronic address: alberto.bacci@icm-institute.org.
authors: Alberto
authors: A
authors: Bacci
mesh_terms: D000818:Animals; D019579:Neocortex / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid
keywords: GABAergic plasticity; inhibition; neocortex; retrograde signaling