title: Additional Targeted Biopsy in Clinically Suspected Prostate Cancer: Prospective Randomized Comparison between Contrast-Enhanced Ultrasound and Sonoelastography Guidance.
abstract: Our aim was to improve the detection of prostate cancer by evaluating whether contrast-enhanced ultrasound (CEUS) or sonoelastography (SE) is more helpful in guiding targeted biopsy (TB) performed before systematic biopsy (SB). A total of 52 patients suspected of having prostate cancer were prospectively included and randomly assigned to either the CEUS or SE group. Different, independent radiologists performed TB and twelve-core SB. Within each group, cancer detection rates based on core number were compared between SB and TB. We evaluated the effect of TB on core-based cancer detection rates between the CEUS and SE groups. Cancer detection was higher in overall TB cores 16.4% (28/171) than SB cores 11.4% (71/624) in both groups. In the SE group, TB cores revealed higher cancer detection than did SB cores from 4.49% (14/312) to 12.86% (9/70) (p = 0.01). Compared with CEUS, SE may improve detection rates when considering additional TB guidance methods.
authors: Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
authors: Jieun
authors: J
authors: Koh
authors: Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. Electronic address: daechul@yuhs.ac.
authors: Dae Chul
authors: DC
authors: Jung
authors: Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
authors: Young Taik
authors: YT
authors: Oh
authors: Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
authors: Moon Gyu
authors: MG
authors: Yoo
authors: Department of Pathology, Cha Medical College, Gang-Nam Cha Hospital, Seoul, Korea.
authors: Songmi
authors: S
authors: Noh
authors: Avison Biomedical Research Center, Department of Radiology; Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
authors: Kyung Hwa
authors: KH
authors: Han
authors: Department of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Koon-Ho
authors: KH
authors: Rha
authors: Department of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Young Deuk
authors: YD
authors: Choi
authors: Department of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Sung Joon
authors: SJ
authors: Hong
mesh_terms: D001706:Biopsy; D003287:Contrast Media; D054459:Elasticity Imaging Techniques; D006801:Humans; D007089:Image Enhancement; D008297:Male; D008875:Middle Aged; D010743:Phospholipids; D011446:Prospective Studies; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D015203:Reproducibility of Results; D013459:Sulfur Hexafluoride; D018615:Ultrasonography, Doppler, Color; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride
keywords: Contrast medium; Elastography; Image-guided biopsy; Prostate cancer; Ultrasound