title: Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese: Evidence From an Updated Meta-Analysis of 27 Studies.
abstract: BACKGROUND
  Many epidemiology studies have indicated that several functional polymorphisms of the IL-27 gene may contribute to individual susceptibility to cancer. Nevertheless, the data arising from these studies were inconclusive. Therefore, we conducted the current meta-analysis aiming to elucidate the effects of IL-27 polymorphisms (rs153109, rs17855750, and rs181206) on cancer susceptibility.
  
  
  METHODS
  We searched the CNKI (Chinese National Knowledge Infrastructure), Wanfang database, PubMed, Web of Science, and Google Scholar for all eligible publications. We used odds ratios (ORs) corresponding with 95% confidence intervals (CIs) by using the random/fixed-effects model to evaluate the association. Finally, a total of 12 publications, including 27 case-control studies comprising of 7570 patients and 9839 controls, were enrolled in our meta-analysis.
  
  
  RESULTS
  Our work demonstrates that IL-27 rs17855750 polymorphism is significantly associated with cancer susceptibility, particularly for bladder cancer. However, no association between IL-27 rs153109 and rs181206 polymorphisms and cancer susceptibility was identified. When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism. Moreover, in the stratification analysis by genotyping method, we identified an increased susceptibility for PCR-RFLP group in rs17855750 polymorphism, whereas a decreased susceptibility was identified in rs153109 polymorphism.
  
  
  CONCLUSIONS
  Our study shows that IL-27 rs17855750 polymorphism is significantly associated with increased susceptibility to cancer in Chinese.
authors: Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).
authors: Meng
authors: M
authors: Zhang
authors: Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).
authors: Xiuxiu
authors: X
authors: Tan
authors: Department of Medicine, Shenzhen University, Shenzhen, Guangdong, China (mainland).
authors: Junjie
authors: J
authors: Huang
authors: Department of Medicine, Shenzhen University, Shenzhen, Guangdong, China (mainland).
authors: Zekai
authors: Z
authors: Ke
authors: Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors: Yukun
authors: Y
authors: Ge
authors: Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
authors: Hu
authors: H
authors: Xiong
authors: Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).
authors: Wei
authors: W
authors: Lu
authors: Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
authors: Lu
authors: L
authors: Fang
authors: Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).
authors: Zhiming
authors: Z
authors: Cai
authors: Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).
authors: Song
authors: S
authors: Wu
mesh_terms: D002681:China; D020022:Genetic Predisposition to Disease; D006801:Humans; D064094:Interleukin-27 / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D064094:Interleukin-27