title: Cyclin D1 G870A polymorphism and glioma risk in a Chinese population.
abstract: BACKGROUND
  A number of studies have suggested that the Cyclin D1 (CCND1) G870A polymorphism was associated with susceptibility to various cancers. In the present study, we aimed to investigate the association between CCND1 G870A polymorphism and the risk of glioma in a Chinese population.
  
  
  METHODS
  CCND1 genotyping was determined by the PCR-RFLP method. The χ (2) test was used to assess for any deviation of the genotype frequencies from Hardy-Weinberg equilibrium and to compare the genotype distributions among glioma patients and healthy control subjects. We calculated the odds ratios (ORs) and 95% confidence intervals (95% CIs) by using unconditional logistic regression.
  
  
  RESULTS
  The A allele frequency was higher in cases than that in controls (49.40% vs. 36.39%), and this difference was statistically significant (P = 0.001). Using the G allele as the reference allele, the subjects carrying the A allele had 3.926-fold increase in the risk of glioma (95% CI, 2.172-7.889), and p-value was significant (P = 0.007). Compared to individuals with the GG genotype, individuals with the AA genotype exhibited significantly increased glioma risk (OR = 3.661, 95% CI: 1.658-6.287, P = 0.01).
  
  
  CONCLUSIONS
  Our results suggest that the CCND1 G870A polymorphism may contribute to the susceptibility to glioma in Chinese population.
authors: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P.R. China.
authors: Hao
authors: H
authors: Liu
authors: Department of Neurology, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P.R. China.
authors: Zhi
authors: Z
authors: Song
authors: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P.R. China.
authors: Da-Guang
authors: DG
authors: Liao
authors: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P.R. China.
authors: Tian-Yi
authors: TY
authors: Zhang
authors: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P.R. China.
authors: Feng
authors: F
authors: Liu
authors: Department of Neurology, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P.R. China.
authors: Wen
authors: W
authors: Zheng
authors: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P.R. China.
authors: Kui
authors: K
authors: Luo
authors: Department of Neurosurgery, The Third Xiangya Hospital of Central South University Changsha 410013, Hunan, P.R. China.
authors: Liang
authors: L
authors: Yang
keywords: Glioma; case-control study; cyclin D1 gene; polymorphism; risk