title: Mathematical Modelling and Prediction of the Effect of Chemotherapy on Cancer Cells.
abstract: Cancer is a class of diseases characterized by out-of-control cells' growth which affect DNAs and make them damaged. Many treatment options for cancer exist, with the primary ones including surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy and palliative care. Which treatments are used depends on the type, location, and grade of the cancer as well as the person's health and wishes. Chemotherapy is the use of medication (chemicals) to treat disease. More specifically, chemotherapy typically refers to the destruction of cancer cells. Considering the diffusion of drugs in cancer cells and fractality of DNA walks, in this research we worked on modelling and prediction of the effect of chemotherapy on cancer cells using Fractional Diffusion Equation (FDE). The employed methodology is useful not only for analysis of the effect of special drug and cancer considered in this research but can be expanded in case of different drugs and cancers.
authors: School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.
authors: Hamidreza
authors: H
authors: Namazi
authors: School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.
authors: Vladimir V
authors: VV
authors: Kulish
authors: Department of Radiotherapy, Oncology and Palliative care, Sarawak General Hospital, Kuching, Malaysia.
authors: Albert
authors: A
authors: Wong
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004249:DNA Damage; D004058:Diffusion; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents