title: The Prevalence and Genotype of Human Papillomavirus from Patients with Genital Warts in Eastern Guangdong Province.
abstract: BACKGROUND
  Low-risk human papillomavirus (LR-HPV) infection is the main cause of genital warts. LR- HPV genotypes 6 and 11 are associated with genital warts, but there have only been a few published studies about the genotype-specific prevalence of HPV in genital warts in China. The objective of our study was to assess the prevalence of HPV genotypes for clinical cases involving both men and women and to evaluate the potential benefit of a quadrivalent (genotypes 6, 11, 16, and 18) HPV vaccine in eastern Guangdong province of China.
  
  
  METHODS
  A total of 696 eligible patients with genital warts were enrolled during the period Aug 2009 through Oct 2014. Specimens were collected from genital warts, the HPV GenoArray test was used for HPV detection and genotyping, which could detect 21 HPV genotypes, including genotypes 6, 11, 16, and 18.
  
  
  RESULTS
  Among the 696 cases, 675 samples were successfully genotyped. The median age of patients was 32.1 years (range, 16-67 years). The most prevalent genotypes were HPV-6 (285/675, 42.2%), HPV-11 (265/675, 39.3%), HPV-52 (52/675, 7.7%), HPV-16 (51/675, 7.56%), HPV-81 (50/675, 7.40%) and HPV-58 (37/675, 5.48%). Low-risk genotypes predominated, with a prevalence of 96.59%. The cumulative prevalence of genotypes 6 and 11 was 78.7% (531/675), the cumulative prevalence of genotypes 16 and 18 was 11.6% (78/675), and the cumulative prevalence of genotypes 6, 11, 16, and 18 was 82.5% (557/675).
  
  
  CONCLUSIONS
  Our results provide strong evidence that, in eastern Guangdong, different from Western countries, the most prevalent low risk HPV genotypes in patients with genital warts are 6, 11 and 81. The quadrivalent HPV vaccine could prevent 82.5% of genital warts in eastern Guangdong.
authors: Central Laboratory, Chaozhou Central Hospital, Chaozhou, Guangdong Province, China E-mail : yangleeyee@sina.com.
authors: Zhao-Yun
authors: ZY
authors: Luo
authors: Qiang
authors: Q
authors: Chen
authors: Hui
authors: H
authors: Yang
authors: Min
authors: M
authors: Lin
authors: Chan-Yu
authors: CY
authors: Chen
authors: Chun
authors: C
authors: Yang
authors: Li-Ye
authors: LY
authors: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D003218:Condylomata Acuminata / Q000453:epidemiology / Q000235:genetics* / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000235:genetics* / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D004279:DNA, Viral