title: Dietary prevention of Helicobacter pylori-associated gastric cancer with kimchi.
abstract: To prove whether dietary intervention can prevent Helicobacter pylori-induced atrophic gastritis and gastric cancer, we developed cancer preventive kimchi (cpKimchi) through special recipe and administered to chronic H. pylori-initiated, high salt diet-promoted, gastric tumorigenesis mice model. H. pylori-infected C57BL/6 mice were administered with cpKimchi mixed in drinking water up to 36 weeks. Gross and pathological gastric lesions were evaluated after 24 and 36 weeks, respectively and explored underlying molecular changes to explain efficacies. Cancer preventive actions of anti-inflammation and anti-mutagenesis were compared between standard recipe kimchi (sKimchi) and special recipe cpKimchi in in vitro H. pylori-infected cell model. The erythematous and nodular changes, mucosal ulcerative and erosive lesions in the stomach were noted at 24th weeks, but cpKimchi administration significantly ameliorated. After 36th weeks, scattered nodular masses, some ulcers, and thin nodular gastric mucosa were noted in H. pylori-infected mice, whereas these gross lesions were significantly attenuated in cpKimchi group. On molecular analysis, significant expressions of COX-2 and IL-6, activated NF-κB and STAT3, increased apoptosis, and marked oxidative stresses were noted in H. pylori-infected group relevant to tumorigenesis, but these were all significantly attenuated in cpKimchi group. cpKimchi extracts imparted significant selective induction of apoptosis only in cancer cells, led to inhibition of H. pylori-induced proliferation, while no cytotoxicity through significant HO-1 induction in non-transformed gastric cells. In conclusion, daily dietary intake of cpKimchi can be an effective way either to rejuvenate H. pylori-atrophic gastritis or to prevent tumorigenesis supported with the concerted actions of anti-oxidative, anti-inflammatory, and anti-mutagenic mechanisms.
authors: CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul, Korea.
authors: Migyeong
authors: M
authors: Jeong
authors: CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul, Korea.
authors: Jong-Min
authors: JM
authors: Park
authors: CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul, Korea.
authors: Young-Min
authors: YM
authors: Han
authors: College of Nutrition, Busan National University, Busan, Korea.
authors: Kun Young
authors: KY
authors: Park
authors: Department of Gastroenterology, School of Medicine, Inha University, Incheon, Korea.
authors: Don Haeng
authors: DH
authors: Lee
authors: Digestive Disease Center, CHA University Bundang Medical Center, Seongnam, Korea.
authors: Joon-Hwan
authors: JH
authors: Yoo
authors: Digestive Disease Center, CHA University Bundang Medical Center, Seongnam, Korea.
authors: Joo Young
authors: JY
authors: Cho
authors: CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul, Korea.|Digestive Disease Center, CHA University Bundang Medical Center, Seongnam, Korea.
authors: Ki-Baik
authors: KB
authors: Hahm
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism; D004032:Diet; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D005756:Gastritis / Q000150:complications / Q000517:prevention & control; D015870:Gene Expression / Q000187:drug effects; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology; D051547:Heme Oxygenase-1 / Q000378:metabolism; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D055670:Medicine, Korean Traditional; D008565:Membrane Proteins / Q000378:metabolism; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism; D028321:Plant Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050796:STAT3 Transcription Factor / Q000378:metabolism; D013274:Stomach Neoplasms / Q000150:complications / Q000517:prevention & control*
chemical_list: D015850:Interleukin-6; D008565:Membrane Proteins; D016328:NF-kappa B; D028321:Plant Preparations; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D051547:Heme Oxygenase-1; C496542:Hmox1 protein, mouse; D051546:Cyclooxygenase 2
keywords: Helicobacter pylori; anti-inflammation; anti-mutagenesis; cancer preventive kimchi; rejuvenation