title: Oxidation of Two Pregnane Steroids Catalyzed by the Fungus Cephalosporium aphidicola.
abstract: Two pregnane steroids, pregnane (1) and 3β-hydroxypregnane (2), were oxidized by fermentation with the fungus Cephalosporium aphidicola. The fermentation of pregnane (1) yielded 3β-hydroxypregnane (2) and 3β, 6β,11α-trihydroxypregnane (3), while that of 3β-hydroxypregnane (2) afforded 6β,11α-dihydroxypregn-3,20-dione (4), 3β,6β,15α-trihydroxypregn-20-one (5) and 3β,5α,11α-trihydroxypregn-20-one (6). The metabolites are characterized by detailed physical and spectroscopic studies.
authors: a School of Molecular Sciences, University of Sussex.
authors: A
authors: A
authors: Farooq
authors: J R
authors: JR
authors: Hanson
mesh_terms: D000164:Acremonium / Q000378:metabolism*; D055162:Biocatalysis; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D005285:Fermentation; D006900:Hydroxylation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011278:Pregnanes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001688:Biological Products; D011278:Pregnanes
keywords: Cephalosporium aphidicola; fermentation; hydroxylation; oxidation; pregnane steroid