title: Wnt signaling induces epithelial differentiation during cutaneous wound healing.
abstract: Cutaneous wound repair in adult mammals typically does not regenerate original dermal architecture. Skin that has undergone repair following injury is not identical to intact uninjured skin. This disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryonic skin development and thus we seek a deeper understanding of the role that Wnt signaling plays in the mechanisms of skin repair in both fetal and adult wounds. The influence of secreted Wnt signaling proteins in tissue homeostasis has galvanized efforts to identify small molecules that target Wnt-mediated cellular responses. Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programmed cell death, to the mobilization of stem cell reservoirs within the wound site. Endogenous Wnt signaling augmentation represents an attractive option to aid in the restoration of cutaneous wounds, as the complex mechanisms of the Wnt pathway have been increasingly investigated over the years. In this review, we summarize recent data elucidating the roles that Wnt signaling plays in cutaneous wound healing process.
authors: a Division of Plastic and Reconstructive Surgery; Department of Surgery; Stanford School of Medicine ; Stanford , CA USA. Khosrow-Houschyar@gmx.de|b Clinic for Plastic and Reconstructive Surgery ; Bergmannstrost Halle , Germany.
authors: Khosrow S
authors: KS
authors: Houschyar
authors: a Division of Plastic and Reconstructive Surgery; Department of Surgery; Stanford School of Medicine ; Stanford , CA USA.
authors: Arash
authors: A
authors: Momeni
authors: a Division of Plastic and Reconstructive Surgery; Department of Surgery; Stanford School of Medicine ; Stanford , CA USA.
authors: Malcolm N
authors: MN
authors: Pyles
authors: a Division of Plastic and Reconstructive Surgery; Department of Surgery; Stanford School of Medicine ; Stanford , CA USA.
authors: Zeshaan N
authors: ZN
authors: Maan
authors: a Division of Plastic and Reconstructive Surgery; Department of Surgery; Stanford School of Medicine ; Stanford , CA USA.
authors: Alexander J
authors: AJ
authors: Whittam
authors: b Clinic for Plastic and Reconstructive Surgery ; Bergmannstrost Halle , Germany.
authors: Frank
authors: F
authors: Siemers
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008954:Models, Biological; D012867:Skin / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology*; D060449:Wnt Signaling Pathway; D014945:Wound Healing / Q000502:physiology*
keywords: Wnt; regeneration; repair; skin; stem cells; ß-catenin