title: Towards a minimally invasive sampling tool for high resolution tissue analytical mapping.
abstract: Multiple spatial mapping techniques of biological tissues have been proposed over the years, but all present limitations either in terms of resolution, analytical capacity or invasiveness. Ren et al (2015 Nanotechnology 26 284001) propose in their most recent work the use of a picosecond infrared laser (PIRL) under conditions of ultrafast desorption by impulsive vibrational excitation (DIVE) to extract small amounts of cellular and molecular components, conserving their viability, structure and activity. The PIRL DIVE technique would then work as a nanobiopsy with minimal damage to the surrounding tissues, which could potentially be applied for high resolution local structural characterization of tissues in health and disease with the spatial limit determined by the laser focus.
authors: Department of Orthopaedic Surgery, Center for Cellular and Molecular Engineering, University of Pittsburgh, 450 Technology Drive, 15219, Pittsburgh, PA, USA. Department of Chemical and Petroleum Engineering, University of Pittsburgh, 3700 O'Hara Street, 15261, Pittsburgh, PA, USA. Fondazione Ri.MED, via Bandiera 11, I-90133 Palermo, Italy.
authors: R
authors: R
authors: Gottardi
mesh_terms: D001706:Biopsy / Q000295:instrumentation*; D003952:Diagnostic Imaging / Q000295:instrumentation*; D050997:Nanomedicine / Q000295:instrumentation*