title: Peroxisome biogenesis in mammalian cells: The impact of genes and environment.
abstract: The initiation and progression of many human diseases are mediated by a complex interplay of genetic, epigenetic, and environmental factors. As all diseases begin with an imbalance at the cellular level, it is essential to understand how various types of molecular aberrations, metabolic changes, and environmental stressors function as switching points in essential communication networks. In recent years, peroxisomes have emerged as important intracellular hubs for redox-, lipid-, inflammatory-, and nucleic acid-mediated signaling pathways. In this review, we focus on how nature and nurture modulate peroxisome biogenesis and function in mammalian cells. First, we review emerging evidence that changes in peroxisome activity can be linked to the epigenetic regulation of cell function. Next, we outline how defects in peroxisome biogenesis may directly impact cellular pathways involved in the development of disease. In addition, we discuss how changes in the cellular microenvironment can modulate peroxisome biogenesis and function. Finally, given the importance of peroxisome function in multiple aspects of health, disease, and aging, we highlight the need for more research in this still understudied field.
authors: Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU Leuven-University of Leuven, Herestraat 49 box 601, B-3000 Leuven, Belgium; Department of Pharmacology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA.
authors: Rebecca L
authors: RL
authors: Farr
authors: Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU Leuven-University of Leuven, Herestraat 49 box 601, B-3000 Leuven, Belgium.
authors: Celien
authors: C
authors: Lismont
authors: Department of Pharmacology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA.
authors: Stanley R
authors: SR
authors: Terlecky
authors: Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU Leuven-University of Leuven, Herestraat 49 box 601, B-3000 Leuven, Belgium. Electronic address: marc.fransen@med.kuleuven.be.
authors: Marc
authors: M
authors: Fransen
mesh_terms: D000107:Acetylation; D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D059647:Gene-Environment Interaction; D051548:Histone Acetyltransferases / Q000235:genetics / Q000378:metabolism; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism; D001678:Organelle Biogenesis; D010084:Oxidation-Reduction; D020675:Peroxisomes / Q000737:chemistry / Q000378:metabolism*; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D006657:Histones; D022661:RNA, Untranslated; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases
keywords: Age-related disease; Biogenesis disorder; Epigenetics; Intracellular signaling; Mitochondria; Peroxisome