title: Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid.
abstract: Neonatal hypoxic ischemic encephalopathy (HIE) is a common disease caused by perinatal asphyxia, a major cause of neonatal death, neurological behavior, and long-term disability. Currently, the diagnosis and prognosis of neonatal HIE are based on nervous system clinical manifestations, imaging and electrophysiological examination. These take time and late diagnosis allows brain injury to occur in newborns, so that infants of many brain injury missed the best treatment time, left with varying degrees of neurological sequelae. The use of biomarkers to monitor brain injury and evaluate neuroprotective effects might allow the early intervention and treatment of neonatal HIE to reduce mortality rates. This study reviewed the mechanism of neonatal hypoxic ischemic encephalopathy in relation to numerous brain-related biomarkers including NSE, S-100β, GFAP, UCH-L1, Tau protein, miRNA, LDH, and CK-BB. In early diagnosis of neonatal HIE, S-100β and activin A seems to be better biomarkers. Biomarkers with the greatest potential to predict long-term neurologic handicap of neonates with HIE are GFAP and UCH-L1 and when combined with other markers or brain imaging can increase the detection rate of HIE. Tau protein is a unique biological component of nervous tissues, and might have value for neonatal HIE diagnosis. Combination of more than two biological markers should be a future research direction.
authors: Department of Neonatology, Handan Maternal and Child Care Centers, Handan 056002, Hebei Province, PR China; Department of Neonatal pathology, Handan Maternal and Child Care Centers, Handan 056002, Hebei Province, PR China.
authors: Hongyan
authors: H
authors: Lv
authors: Department of Neonatology, Handan Maternal and Child Care Centers, Handan 056002, Hebei Province, PR China.
authors: Qiuli
authors: Q
authors: Wang
authors: Department of Neonatology, Handan Maternal and Child Care Centers, Handan 056002, Hebei Province, PR China; Department of Neonatal pathology, Handan Maternal and Child Care Centers, Handan 056002, Hebei Province, PR China.
authors: Sujing
authors: S
authors: Wu
authors: Department of Neonatology, Handan Maternal and Child Care Centers, Handan 056002, Hebei Province, PR China.
authors: Lihong
authors: L
authors: Yang
authors: Department of Neonatology, Handan Maternal and Child Care Centers, Handan 056002, Hebei Province, PR China.
authors: Pengshun
authors: P
authors: Ren
authors: Department of Neural development and neural pathology, Hebei University of Engineering School of Medicine, Handan 056029, Hebei Province, PR China.
authors: Yihui
authors: Y
authors: Yang
authors: Department of Pathology, Hebei University of Engineering School of Medicine, Handan 056029, Hebei Province, PR China.
authors: Jinsheng
authors: J
authors: Gao
authors: Department of Neonatal pathology, Handan Maternal and Child Care Centers, Handan 056002, Hebei Province, PR China; Department of Neural development and neural pathology, Hebei University of Engineering School of Medicine, Handan 056029, Hebei Province, PR China. Electronic address: lianxianglm68@163.com.
authors: Lianxiang
authors: L
authors: Li
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood* / Q000134:cerebrospinal fluid*; D007231:Infant, Newborn
chemical_list: D015415:Biomarkers
keywords: Biomarker; Cerebrospinal fluid; Hypoxic ischemic encephalopathy; Newborn; Serum