title: Gliomatosis cerebri with spinal metastasis presenting with chronic meningitis in two boys.
abstract: Spinal cord involvement in gliomatosis cerebri (GC) is uncommon. We report two patients with GC, who initially presented with chronic meningitis and were treated with antituberculous drugs. Although tumor meningitis was suspected, due to the intractable clinical course, a correct diagnosis was established after performing a biopsy examination of the metastatic spinal lesion which was detected by magnetic resonance imaging (MRI). Cerebrospinal fluid examination, including cytology, should be performed repetitively for patients with chronic meningitis refractory to antibiotic treatment. Spinal MRI is necessary for the complete neurological workup, even when the patients do not show spinal symptoms.
authors: Department of Pediatrics, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.
authors: Yi-Heng
authors: YH
authors: Lin
authors: Department of Pediatrics, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.
authors: Yen-Wen
authors: YW
authors: Chang
authors: Department of Surgery, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.
authors: Shih-Hung
authors: SH
authors: Yang
authors: Department of Pediatrics, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.
authors: Hsiu-Hao
authors: HH
authors: Chang
authors: Department of Pediatrics, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.
authors: Meng-Yao
authors: MY
authors: Lu
authors: Department of Pediatrics, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan. Electronic address: pcfan6@ntu.edu.tw.
authors: Pi-Chuan
authors: PC
authors: Fan
mesh_terms: D000293:Adolescent; D001706:Biopsy; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D002648:Child; D004358:Drug Therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis; D018302:Neoplasms, Neuroepithelial / Q000473:pathology* / Q000628:therapy; D011878:Radiotherapy; D013125:Spinal Neoplasms / Q000556:secondary* / Q000628:therapy; D014057:Tomography, X-Ray Computed
keywords: chronic meningitis; gliomatosis cerebri; spinal metastasis; tuberculosis