title: En face optical coherence tomography angiography for corneal neovascularisation.
abstract: OBJECTIVE
  Recently, there has been an increasing clinical need for objective evaluation of corneal neovascularisation, a condition which cause significant ocular morbidity. We describe the use of a rapid, non-invasive 'en face' optical coherence tomography angiography (OCTA) system for the assessment of corneal neovascularisation.
  
  
  METHODS
  Consecutive patients with abnormal corneal neovascularisation were scanned using a commercially available AngioVue OCTA system (Optovue, Fremont, California, USA) with the split-spectrum amplitude decorrelation angiography algorithm, using an anterior segment lens adapter. Each subject had four scans in each eye by a trained operator and two independent masked assessors analysed all images. Main outcome measures were scan quality (signal strength, image quality), area of neovascularisation and repeatability of corneal vascular grade.
  
  
  RESULTS
  We performed OCTA in 20 patients (11 men, 9 women, mean age 49.27±17.23 years) with abnormal corneal neovascularisation. The mean area of corneal neovascularisation was 0.57±0.30 mm(2) with a mean neovascularisation grade of 3.5±0.2 in the OCTA scans. We found the OCTA to produce good quality images of the corneal vessels (signal strength: 36.95±13.97; image quality score 2.72±1.07) with good repeatability for assessing neovascularisation grade (κ=0.84).
  
  
  CONCLUSIONS
  In this preliminary clinical study, we describe a method for acquiring angiography images with 'en face' views, using an OCTA system adapted for the evaluation of corneal neovascularisation. Further studies are required to compare the scans to other invasive angiography techniques for the quantitative evaluation of abnormal corneal vessels.
authors: Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors: Marcus
authors: M
authors: Ang
authors: Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors: Yijun
authors: Y
authors: Cai
authors: Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors: Shahab
authors: S
authors: Shahipasand
authors: Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors: Dawn A
authors: DA
authors: Sim
authors: Moorfields Eye Hospital NHS Foundation Trust, London, UK Institute of Ophthalmology, University College London, London, UK.
authors: Pearse A
authors: http://orcid.org/0000-0002-9239-745X
authors: PA
authors: Keane
authors: Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore Moorfields Eye Hospital NHS Foundation Trust, London, UK Department of Ophthalmology, National University Hospital, Singapore, Singapore.
authors: Chelvin C A
authors: CC
authors: Sng
authors: Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors: Catherine A
authors: CA
authors: Egan
authors: Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors: Adnan
authors: A
authors: Tufail
authors: Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors: Mark R
authors: MR
authors: Wilkins
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D003315:Cornea / Q000098:blood supply*; D016510:Corneal Neovascularization / Q000145:classification / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence
keywords: Cornea; Imaging; Neovascularisation