title: Modulation of endoplasmic reticulum stress in Parkinson's disease.
abstract: Parkinson's disease is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra in the midbrain. However, the etiology of the reduction in dopaminergic neurons remains unclear. Recently, it has been suggested that oxidative stress, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction are involved in neuronal cell death in the pathology of Parkinson's disease. Furthermore, it has been suggested that some existing anti- Parkinson's disease drugs have protective effects against cell death. Among these, zonisamide exerts neuroprotective effects partly by modulating ER stress. Elucidating the involvement of ER stress in in vitro and in vivo Parkinson's disease models and investigating the mechanisms against ER stress will contribute to the search for new therapeutic agents for Parkinson's disease.
authors: Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan.
authors: Saori
authors: S
authors: Tsujii
authors: Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan.
authors: Mitsue
authors: M
authors: Ishisaka
authors: Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan. Electronic address: hidehara@gifu-pu.ac.jp.
authors: Hideaki
authors: H
authors: Hara
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology / Q000627:therapeutic use; D059290:Dopaminergic Neurons / Q000187:drug effects / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism*; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism
chemical_list: D000978:Antiparkinson Agents; D018696:Neuroprotective Agents
keywords: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (PubChem CID: 1388); 1-methyl-4-phenylpyridinium (PubChem CID: 6918492); Endoplasmic reticulum stress; Parkinson's disease; Zonisamide; zonisamide (PubChem CID: 5734)