title: B cells regulate antidonor T-cell reactivity in transplantation.
abstract: The analyses of indirect T-cell responses in patients with antibody-mediated renal transplant injury by Shiu et al. emphasize the complex contribution of B cells in alloimmunity. The data suggest at least three distinct but potentially overlapping consequences of T cell-B cell interactions: antigen presentation by B cells, alloantibody production, and immune regulation. These multifaceted functions of B cells should be taken into consideration in developing diagnostic tools and therapeutic strategies.
authors: Glickman Urological Institute and Department of Immunology, Cleveland Clinic, Cleveland, Ohio, USA.
authors: Anna N
authors: AN
authors: Valujskikh
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D002450:Cell Communication; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral; D007668:Kidney / Q000276:immunology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000276:immunology*