title: [Comparison of clinical characteristics and laboratory parameters of patients with dermatomyositis-specific autoantibodies and autoantibody-negative patients].
abstract: BACKGROUND
  Myositis is an autoimmune disease characterised by proximal muscle weakness.
  
  
  OBJECTIVE
  The aim of the authors was to determine the frequency of dermatomyositis-specific autoantibodies (anti-Mi-2, anti-transcriptional intermediary factor 1 gamma, anti-nuclear matrix protein 2, anti-small ubiquitin-like modifier activating enzyme, anti-melanoma differentiation-associated gene) in a Hungarian myositis population and to compare the clinical features with the characteristics of patients without myositis-specific antibodies.
  
  
  METHODS
  Antibodies were detected using immunoblot and immunoprecipitation.
  
  
  RESULTS
  Of the 330 patients with myositis, 48 patients showed dermatomyositis-specific antibody positivity. The frequency of antibodies in these patients was lower than those published in literature Retrospective analysis of clinical findings and medical history revealed that patients with dermatomyositis-specific autoantibody had more severe muscle weakness and severe skin lesions at the beginning of the disease.
  
  
  CONCLUSIONS
  Antibodies seem to be useful markers for distinct clinical subsets, for predicting the prognosis of myositis and the effectiveness of the therapy.
authors: Belgyógyászati Intézet, Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ Debrecen, Móricz Zs. körút 22., 4032.
authors: Levente
authors: L
authors: Bodoki
authors: Dóra
authors: D
authors: Budai
authors: Melinda
authors: M
authors: Nagy-Vincze
authors: Zoltán
authors: Z
authors: Griger
authors: Zoe
authors: Z
authors: Betteridge
authors: Katalin
authors: K
authors: Dankó
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D003882:Dermatomyositis / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D015151:Immunoblotting; D047468:Immunoprecipitation; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000276:immunology*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; C045760:Mi-2 antibodies
keywords: anti-Mi-2; anti-NXP2; anti-TIF1-γ; anti-TIF1γ; myositis; myositis-specific autoantibody; myositisspecifikus autoantitest