title: A Supramolecular Antibiotic Switch for Antibacterial Regulation.
abstract: A supramolecular antibiotic switch is described that can reversibly "turn-on" and "turn-off" its antibacterial activity on demand, providing a proof-of-concept for a way to regulate antibacterial activity of biotics. The switch relies on supramolecular assembly and disassembly of cationic poly(phenylene vinylene) derivative (PPV) with cucurbit[7]uril (CB[7]) to regulate their different interactions with bacteria. This simple but efficient strategy does not require any chemical modification on the active sites of the antibacterial agent, and could also regulate the antibacterial activity of classical antibiotics or photosensitizers in photodynamic therapy. This supramolecular antibiotic switch may be a successful strategy to fight bacterial infections and decrease the emergence of bacterial resistance to antibiotics from a long-term point of view.
authors: Beijing National Laboratory for Molecular Sciences,, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China).
authors: Haotian
authors: H
authors: Bai
authors: Beijing National Laboratory for Molecular Sciences,, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China).
authors: Huanxiang
authors: H
authors: Yuan
authors: Beijing National Laboratory for Molecular Sciences,, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China).
authors: Chenyao
authors: C
authors: Nie
authors: Beijing National Laboratory for Molecular Sciences,, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China).
authors: Bing
authors: B
authors: Wang
authors: Beijing National Laboratory for Molecular Sciences,, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China). lvft@iccas.ac.cn.
authors: Fengting
authors: F
authors: Lv
authors: Beijing National Laboratory for Molecular Sciences,, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China).
authors: Libing
authors: L
authors: Liu
authors: Beijing National Laboratory for Molecular Sciences,, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China). wangshu@iccas.ac.cn.
authors: Shu
authors: S
authors: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D007093:Imidazoles / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D011145:Polyvinyls / Q000737:chemistry*; D013329:Structure-Activity Relationship; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D000900:Anti-Bacterial Agents; D001952:Bridged-Ring Compounds; D007093:Imidazoles; D046911:Macromolecular Substances; D017319:Photosensitizing Agents; D011145:Polyvinyls; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils; C470024:poly(4-phenylenevinylene)
keywords: antibacterial regulation; antibiotics; bacterial resistance; molecular switches; supramolecular assembly