title: Fasting Lipoprotein Lipase Protein Levels Can Predict a Postmeal Increment of Triglyceride Levels in Fasting Normohypertriglyceridemic Subjects.
abstract: BACKGROUND
  Although a postprandial increment in triglyceride (TG) levels is considered to be a risk factor for atherogenesis, tests (e.g., fat load) to assess postprandial changes in TG levels cannot be easily applied to clinical practice. Therefore, fasting markers that predict postprandial TG states are needed to be developed. One current candidate is lipoprotein lipase (LPL) protein, a molecule that hydrides TGs. This study investigated whether fasting LPL levels could predict postprandial TG levels.
  
  
  METHODS
  A total of 17 subjects (11 men, 6 women, mean age 52 ± 11 years) with normotriglyceridemia during fasting underwent the meal test. Several fasting parameters, including LPL, were measured for the area under the curve of postprandial TGs (AUC-TG).
  
  
  RESULTS
  The subjects' mean fasting TG level was 1.30 mmol/l, and their mean LPL level was 41.6 ng/ml. The subjects' TG levels increased after loading (they peaked after two postprandial hours). Stepwise multiple regression analysis demonstrated that fasting TG levels were a predictor of the AUC-TG. In addition, fasting LPL mass levels were found to be a predictor of the AUC-TG (β = 0.65, P < 0.01), and this relationship was independent of fasting TG levels.
  
  
  CONCLUSIONS
  Fasting LPL levels may be useful to predict postprandial TG increment in this population.
authors: Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors: Kokoro
authors: K
authors: Tsuzaki
authors: Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan. kazukotani@jichi.ac.jp.|Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp.
authors: Kazuhiko
authors: K
authors: Kotani
authors: Diabetes Center, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors: Kazunori
authors: K
authors: Yamada
authors: Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors: Naoki
authors: N
authors: Sakane
mesh_terms: D000328:Adult; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology*; D012737:Sex Factors; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D008071:Lipoprotein Lipase
keywords: cardiovascular disease; hypertriglyceridemia; lipoprotein lipase; meal test; postprandial