title: Resveratrol and anti-atherogenic effects.
abstract: The role of inflammation and oxidative stress in atherosclerosis development has been increasingly well recognized over the past decade. Inflammation has a significant role at all stages of atherosclerosis, including initiation, progression and plaque formation. Resveratrol is a naturally occurring polyphenolic compound found in grape products, berry fruits and red wine. Its ability to behave therapeutically as a component of red wine has attracted wide attention. Accumulating evidence suggests that it is a highly pleiotropic molecule that modulates numerous targets and molecular functions. Epidemiological studies indicate that the Mediterranean diet, rich in resveratrol, is associated with a reduced risk of atherosclerosis. Resveratrol is believed to decrease circulating low-density lipoprotein cholesterol levels, reduce cardiovascular disease risk; it reduces lipid peroxidation, platelet aggregation and oxidative stress. Resveratrol is considered a safe compound, since no significant toxic effects have been demonstrated after administration of a broad range of concentrations, and an effective anti-atherogenic agent.
authors: a Cardiology Unit, San Camillo de Lellis Hospital , Manfredonia , Foggia , Italy .
authors: Graziano
authors: G
authors: Riccioni
authors: b Clinical and Human Nutrition Unit, Department of Oral Medical and Biotechnological Sciences, University "G. D'Annunzio" , Chieti , Italy and.
authors: Maria Alessandra
authors: MA
authors: Gammone
authors: c Department of Pediatric Cardiovascular Surgery , IRCCS San Donato Milanese Hospital , San Donato Milanese , Italy.
authors: Guido
authors: G
authors: Tettamanti
authors: c Department of Pediatric Cardiovascular Surgery , IRCCS San Donato Milanese Hospital , San Donato Milanese , Italy.
authors: Sonia
authors: S
authors: Bergante
authors: c Department of Pediatric Cardiovascular Surgery , IRCCS San Donato Milanese Hospital , San Donato Milanese , Italy.
authors: Francesca Romana
authors: FR
authors: Pluchinotta
authors: b Clinical and Human Nutrition Unit, Department of Oral Medical and Biotechnological Sciences, University "G. D'Annunzio" , Chieti , Italy and.
authors: Nicolantonio
authors: N
authors: D'Orazio
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy*; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013267:Stilbenes; D000077185:Resveratrol
keywords: Anti-inflammatory; antioxidant; atherosclerosis; cardiovascular disease; lipids; polyphenol; prevention