title: Baseline characteristics of African Americans in the Systolic Blood Pressure Intervention Trial.
abstract: The Systolic Blood Pressure Intervention Trial (SPRINT) will compare treatment to a systolic blood pressure goal of <120 mm Hg to treatment to the currently recommended goal of <140 mm Hg for effects on incident cardiovascular, renal, and neurologic outcomes including cognitive decline. The objectives of this analysis are to compare baseline characteristics of African American (AA) and non-AA SPRINT participants and explore factors associated with uncontrolled blood pressure (BP) by race. SPRINT enrolled 9361 hypertensive participants aged older than 50 years. This cross-sectional analysis examines sociodemographics, baseline characteristics, and study measures among AAs compared with non-AAs. AAs made up 31% of participants. AAs (compared with non-AAs) were younger and less frequently male, had less education, and were more likely uninsured or covered by Medicaid. In addition, AAs scored lower on the cognitive screening test when compared with non-AAs. Multivariate logistic regression analysis found BP control rates to <140/90 mm Hg were higher for AAs who were male, had higher number of chronic diseases, were on diuretic treatment, and had better medication adherence. SPRINT is well poised to examine the effects of systolic blood pressure targets on clinical outcomes as well as predictors influencing BP control in AAs.
authors: Division of Nephrology and Hypertension, Clinical Hypertension Program, University Hospitals Case Medical Center, Cleveland, OH, USA; Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA. Electronic address: cwh11@case.edu.
authors: Carolyn H
authors: CH
authors: Still
authors: Department of Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors: Timothy E
authors: TE
authors: Craven
authors: Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors: Barry I
authors: BI
authors: Freedman
authors: Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Peter N
authors: PN
authors: Van Buren
authors: Wake Forest School of Medicine, Section on Geriatrics and Gerontology, Winston-Salem, NC, USA.
authors: Kaycee M
authors: KM
authors: Sink
authors: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors: Anthony A
authors: AA
authors: Killeen
authors: Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA.
authors: Jeffrey T
authors: JT
authors: Bates
authors: Division of Nephrology and Hypertension, Clinical Hypertension Program, University Hospitals Case Medical Center, Cleveland, OH, USA.
authors: Alberta
authors: A
authors: Bee
authors: Nephrology Department, University of Miami Miller School of Medicine, Miami, FL, USA.
authors: Gabriel
authors: G
authors: Contreras
authors: Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors: Suzanne
authors: S
authors: Oparil
authors: Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest Baptist Health, Winston-Salem, NC, USA.
authors: Carolyn M
authors: CM
authors: Pedley
authors: Memphis Veterans Affairs Medical Center, Memphis, TN, USA.
authors: Barry M
authors: BM
authors: Wall
authors: Department of Internal Medicine, Northeast Ohio Neighborhood Health Services, Inc, Cleveland, OH, USA.
authors: Suzanne
authors: S
authors: White
authors: Department of Medicine, Nephrology Division, Vanderbilt University, Nashville, TN, USA.
authors: Delia M
authors: DM
authors: Woods
authors: Department of Epidemiology and Prevention, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors: Carlos J
authors: CJ
authors: Rodriguez
authors: Division of Nephrology and Hypertension, Clinical Hypertension Program, University Hospitals Case Medical Center, Cleveland, OH, USA; Department of Nephrology and Hypertension, Case Western Reserve University, School of Medicine, Cleveland, OH, USA.
authors: Jackson T
authors: JT
authors: Wright
mesh_terms: D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D044383:Black People; D001794:Blood Pressure; D015992:Body Mass Index; D002908:Chronic Disease / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008484:Medicaid / Q000706:statistics & numerical data; D017057:Medically Uninsured; D055118:Medication Adherence; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012737:Sex Factors; D013599:Systole; D014481:United States / Q000453:epidemiology; D001741:Black or African American
chemical_list: D000959:Antihypertensive Agents
keywords: Cardiovascular disease; SPRINT; blacks; clinical trials; hypertension