title: Novel targets and stimulation paradigms for deep brain stimulation.
abstract: Deep brain stimulation (DBS) is an accepted therapy for appropriately selected patients with movement disorders and psychiatric disease. The recent advances in lead technology and the advent of novel stimulation parameters have spurred a number of improvements that will likely be implemented in the clinical setting. Although the mechanisms and biology of DBS remain poorly understood, the progress in our understanding of network level dysfunction has driven the introduction of a variety of new targets and approaches to the treatment of human disease. Here we summarize the recent advances in novel stimulation patterns and customized field shaping. We also review new targets, novel applications of DBS and the immediate and long-term horizon for this therapy.
authors: a 1 Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, Florida, USA.
authors: Sol
authors: S
authors: De Jesus
authors: Leonardo
authors: L
authors: Almeida
authors: Zhongxing
authors: Z
authors: Peng-Chen
authors: Michael S
authors: MS
authors: Okun
authors: Christopher W
authors: CW
authors: Hess
mesh_terms: D046690:Deep Brain Stimulation / Q000639:trends*; D006801:Humans; D001523:Mental Disorders / Q000628:therapy*; D009069:Movement Disorders / Q000628:therapy*
keywords: Parkinson disease; deep brain stimulation; movement disorders; neuromodulation; neurostimulation