title: Impact of Childhood Adversity and Vasopressin receptor 1a Variation on Social Interaction in Adulthood: A Cross-Sectional Study.
abstract: BACKGROUND
  Arginine vasopressin (AVP) plays a role in social behavior, through receptor AVPR1A. The promoter polymorphism AVPR1A RS3 has been associated with human social behaviors, and with acute response to stress. Here, the relationships between AVPR1A RS3, early-life stressors, and social interaction in adulthood were explored.
  
  
  METHODS
  Adult individuals from a Swedish population-based cohort (n = 1871) were assessed for self-reported availability of social integration and social attachment and for experience of childhood adversities. Their DNA samples were genotyped for the microsatellite AVPR1A RS3.
  
  
  RESULTS
  Among males, particularly those homozygous for the long alleles of AVPR1A RS3 were vulnerable to childhood adversity for their social attachment in adulthood. A similar vulnerability to childhood adversity among long allele carriers was found on adulthood social integration, but here both males and females were influenced.
  
  
  CONCLUSIONS
  Data were self-reported and childhood adversity data were retrospective.
  
  
  CONCLUSIONS
  Early-life stress influenced the relationship between AVPR1A genetic variants and social interaction. For social attachment, AVPR1A was of importance in males only. The findings add to previous reports on higher acute vulnerability to stress in persons with long AVPR1A RS3 alleles and increased AVP levels.
authors: School of Nursing, Shandong University, Jinan, 250012, China; Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
authors: Jia Jia
authors: JJ
authors: Liu
authors: School of Nursing, Shandong University, Jinan, 250012, China.
authors: Fenglan
authors: F
authors: Lou
authors: Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
authors: Catharina
authors: C
authors: Lavebratt
authors: Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
authors: Yvonne
authors: Y
authors: Forsell
mesh_terms: D000328:Adult; D000483:Alleles; D001127:Arginine Vasopressin / Q000235:genetics; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012929:Psychological Distance; D017483:Receptors, Vasopressin / Q000235:genetics*; D012737:Sex Factors; D062487:Social Marginalization / Q000523:psychology*; D013315:Stress, Psychological / Q000235:genetics* / Q000523:psychology
chemical_list: C000599871:AVPR1A protein, human; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin