title: NAT1 polymorphisms and cancer risk: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To investigate the association between the N-acetyltransferase 1 (NAT1) slow and rapid acetylation phenotypes with cancer risk based on a meta-analysis.
  
  
  METHODS
  Previously published case-control studies were retrieved from PubMed, Embase, and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were determined to assess the relationship between NAT1 polymorphisms and cancer risk.
  
  
  RESULTS
  A total of 73 studies (24874 cases and 30226 controls) were included in this meta-analysis. No significant association was identified between NAT1 polymorphisms (slow acetylation versus rapid acetylation genotypes: OR = 0.978, 95% CI = 0.927-1.030, P < 0.001 for heterogeneity, I(2) = 45.5%) and cancer risk, whereas a significantly reduced risk of pancreatic cancer was identified in individuals with NAT1 slow acetylation genotype (OR = 0.856, 95% CI = 0.733-0.999, P =0.509 for heterogeneity, I(2) = 0). When the NAT1 slow acetylation genotype was analysed on the basis of stratified analyses of ethnicity, a significantly reduced risk of head and neck cancers was found among Asian (OR=0.281, 95% CI = 0.127-0.622). When the NAT1 slow acetylation genotype was analysed on the basis of stratified analyses of source of control, only significantly reduced risks of colorectal cancer (OR = 0.882, 95% CI = 0.798- 0.974, P = 0.212 for heterogeneity, I(2) = 22.9) and pancreatic cancer (OR=0.856, 95% CI = 0.733-0.999, P = 0.509 for heterogeneity, I(2) = 0) were found among hospital-based studies.
  
  
  CONCLUSIONS
  No significant association between the NAT1 polymorphisms and the risk of cancer was found except for pancreatic cancer.
authors: Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University Guangzhou 510060, People's Republic of China.
authors: Kunyi
authors: K
authors: Zhang
authors: Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University Guangzhou 510060, People's Republic of China.
authors: Lijuan
authors: L
authors: Gao
authors: Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University Guangzhou 510060, People's Republic of China.
authors: Yuqi
authors: Y
authors: Wu
authors: Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University Guangzhou 510060, People's Republic of China.
authors: Jianyi
authors: J
authors: Chen
authors: Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University Guangzhou 510060, People's Republic of China.
authors: Chengguang
authors: C
authors: Lin
authors: Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University Guangzhou 510060, People's Republic of China.
authors: Shaohua
authors: S
authors: Liang
authors: Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University Guangzhou 510060, People's Republic of China.
authors: Jianxin
authors: J
authors: Su
authors: Internal Medicine, Guangdong Provincial Police Hospital No. 88 West Shitan Road, Guangzhou 510430, PR. China.
authors: Jinming
authors: J
authors: Ye
authors: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences 106 Zhongshan Road 2, Guangzhou 510080, China.
authors: Xuyu
authors: X
authors: He
keywords: N-acetyltransferase 1; cancer; meta-analysis; polymorphism