title: Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma.
abstract: There are no previous studies of the association between prediagnostic serum vitamin D concentration and glioma. Vitamin D has immunosuppressive properties; as does glioma. It was, therefore, our hypothesis that elevated vitamin D concentration would increase glioma risk. We conducted a nested case-control study using specimens from the Janus Serum Bank cohort in Norway. Blood donors who were subsequently diagnosed with glioma (n = 592), between 1974 and 2007, were matched to donors without glioma (n = 1112) on date and age at blood collection and sex. We measured 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D availability, using liquid chromatography coupled with mass spectrometry. Seasonally adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for each control quintile of 25(OH)D using conditional logistic regression. Among men diagnosed with high grade glioma >56, we found a negative trend (P = .04). Men diagnosed ≤ 56 showed a borderline positive trend (P = .08). High levels (>66 nmol/L) of 25(OH)D in men >56 were inversely related to high grade glioma from ≥2 yr before diagnosis (OR = 0.59; 95% CI = 0.38, 0.91) to ≥15 yr before diagnosis (OR = 0.61; 95% CI = 0.38,0.96). Our findings are consistent long before glioma diagnosis and are therefore unlikely to reflect preclinical disease.
authors: a Comprehensive Cancer Center and Division of Epidemiology, College of Public Health , Ohio State University , Columbus , Ohio , USA.
authors: Victoria
authors: V
authors: Zigmont
authors: a Comprehensive Cancer Center and Division of Epidemiology, College of Public Health , Ohio State University , Columbus , Ohio , USA.
authors: Amy
authors: A
authors: Garrett
authors: b Division of Epidemiology , College of Public Health, Ohio State University , Columbus , Ohio , USA.|c Nationwide Children's Hospital , Columbus , Ohio , USA.
authors: Jin
authors: J
authors: Peng
authors: d Division of Biostatistics, College of Public Health and Mathematical Biosciences Institute , Ohio State University , Columbus , Ohio , USA.
authors: Michal
authors: M
authors: Seweryn
authors: d Division of Biostatistics, College of Public Health and Mathematical Biosciences Institute , Ohio State University , Columbus , Ohio , USA.
authors: Grzegorz A
authors: GA
authors: Rempala
authors: a Comprehensive Cancer Center and Division of Epidemiology, College of Public Health , Ohio State University , Columbus , Ohio , USA.
authors: Randall
authors: R
authors: Harris
authors: e Department of Statistics , Ohio State University , Columbus , Ohio , USA.
authors: Christopher
authors: C
authors: Holloman
authors: f Vitas Analytic Services , Oslo , Norway.
authors: Thomas E
authors: TE
authors: Gundersen
authors: g Institute of Environmental Medicine , Division of Epidemiology, Karolinska Institutet , Stockholm , Sweden.
authors: Anders
authors: A
authors: Ahlbom
authors: g Institute of Environmental Medicine , Division of Epidemiology, Karolinska Institutet , Stockholm , Sweden.
authors: Maria
authors: M
authors: Feychting
authors: h Department of Registration , Cancer Registry of Norway , Oslo , Norway.
authors: Tom Borge
authors: TB
authors: Johannesen
authors: h Department of Registration , Cancer Registry of Norway , Oslo , Norway.
authors: Tom Kristian
authors: TK
authors: Grimsrud
authors: a Comprehensive Cancer Center and Division of Epidemiology, College of Public Health , Ohio State University , Columbus , Ohio , USA.
authors: Judith
authors: J
authors: Schwartzbaum
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005910:Glioma / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway; D012737:Sex Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D