title: [Research advance of retinal pathological angiogenesis related to ATM protein kinase].
abstract: Ataxia-telangiectasia mutated (ATM) gene could cause ataxia telangiectasia which is an autosomal recessive disease. The ATM protein kinase encoded by the ATM gene mainly distributed in nucleus as a master regulator of the DNA damage response and apoptosis via cell signaling pathways. The ATM kinase plays a key role in the pathogenesis of cellular senescence and tumor genesis. Recently, some studies have indicated that ATM protein kinase is involved in pathological neovascularization, suggesting that it could be a novel potential therapeutic target in diseases associated with pathological angiogenesis.
authors: BengBu Medical College, Bengbu 233030, China.
authors: Li
authors: L
authors: Lu
authors: Zhi
authors: Z
authors: Zheng
authors: Email: cxli-66@hotmail.com.
authors: Chunxia
authors: C
authors: Li
mesh_terms: D017209:Apoptosis / Q000235:genetics; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics*; D035843:Biomedical Research; D004249:DNA Damage; D006801:Humans; D015861:Retinal Neovascularization / Q000201:enzymology* / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D025521:Tumor Suppressor Proteins; D064007:Ataxia Telangiectasia Mutated Proteins