title: [Feasibility of opportunistic salpingectomy at the time of vaginal hysterectomy for benign pathology and evaluation of occult tubal lesions prevalence: Preliminary study].
abstract: OBJECTIVE
  To assess the feasibility of prophylactic salpingectomy during vaginal hysterectomy for benign pathology and the prevalence of occult tubal lesions.
  
  
  METHODS
  In this prospective study from 09/01/2013 to 11/01/2014, patients who underwent vaginal hysterectomy with salpingectomy or salpingo-oophorectomy were included. The prevalence of bilateral salpingectomy with or without ovariectomy and the prevalence of histopathological and immunohistochemical (p53 expression) abnormalities were evaluated.
  
  
  RESULTS
  Bilateral salpingectomy was performed in 51/69 patients (73.9%). An elevated BMI was statistically associated with a failure of the salpingectomy (29.4 vs 25.8; P=0.01). There was only one case of postoperative hemorrhage in the salpingectomy group. On the 51fallopian tubes, there were 4 (12.9%) immunohistochemical abnormalities "p53 signature".
  
  
  CONCLUSIONS
  The recent tubal origin of most ovarian cancer cases raised the question of the prophylactic salpingectomy in the population with genetic risk as well as in the general population. Bilateral salpingectomy may be performed during vaginal hysterectomy. However caution is needed because we do not know what is the exact evolution of the p53 signatures.
authors: Département de gynécologie, hôpital Femme-Mère-Enfant (HFME), hospices civils de Lyon, CHU de Lyon-Est, 69000 Lyon, France; Université Claude-Bernard Lyon-1, EMR 3738, 69000 Lyon, France.
authors: G
authors: G
authors: Chene
authors: Département de gynécologie, hôpital Femme-Mère-Enfant (HFME), hospices civils de Lyon, CHU de Lyon-Est, 69000 Lyon, France.
authors: C
authors: C
authors: Meysonnier
authors: Département de pathologie, centre hospitalier Est, hospices civils de Lyon, 69000 Lyon, France.
authors: A
authors: A
authors: Buenerd
authors: Département de gynécologie, hôpital Femme-Mère-Enfant (HFME), hospices civils de Lyon, CHU de Lyon-Est, 69000 Lyon, France.
authors: S
authors: S
authors: Moret
authors: Département de pathologie, centre hospitalier Est, hospices civils de Lyon, 69000 Lyon, France.
authors: B
authors: B
authors: Nadaud
authors: Département de gynécologie, hôpital Femme-Mère-Enfant (HFME), hospices civils de Lyon, CHU de Lyon-Est, 69000 Lyon, France.
authors: E
authors: E
authors: Beaufils
authors: Département de gynécologie, hôpital Femme-Mère-Enfant (HFME), hospices civils de Lyon, CHU de Lyon-Est, 69000 Lyon, France.
authors: K
authors: K
authors: Le Bail-Carval
authors: Département de gynécologie, hôpital Femme-Mère-Enfant (HFME), hospices civils de Lyon, CHU de Lyon-Est, 69000 Lyon, France.
authors: P
authors: P
authors: Chabert
authors: Département de gynécologie, hôpital Femme-Mère-Enfant (HFME), hospices civils de Lyon, CHU de Lyon-Est, 69000 Lyon, France.
authors: G
authors: G
authors: Mellier
authors: Département de gynécologie, hôpital Femme-Mère-Enfant (HFME), hospices civils de Lyon, CHU de Lyon-Est, 69000 Lyon, France.
authors: G
authors: G
authors: Lamblin
mesh_terms: D000328:Adult; D000368:Aged; D005184:Fallopian Tube Diseases / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007045:Hysterectomy, Vaginal / Q000592:standards*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000517:prevention & control*; D010052:Ovariectomy / Q000592:standards*; D015995:Prevalence; D011446:Prospective Studies; D058994:Salpingectomy / Q000592:standards*
keywords: Cancer ovaire; Hystérectomie vaginale; Ovarian cancer; Prophylactic salpingectomy; Salpingectomie prophylactique; Signature p53; Vaginal hysterectomy; p53 signature