title: Left brain cortical activity modulates stress effects on social behavior.
abstract: When subjected to stress, some individuals develop maladaptive symptoms whereas others retain normal behavior. The medial prefrontal cortex (mPFC) is known to control these adaptive responses to stress. Here, we show that mPFC neurons in the left hemisphere control stress effects on social behavior. Mice made socially avoidant by the stress of chronic social defeats showed depressed neural activity in the left mPFC. Photoactivation of these neurons reversed social avoidance and restored social activity. Despite social defeats, resilient mice with normal sociability showed normal firing rates in the left mPFC; however, photoinhibition of these neurons induced social avoidance. The same photomodulation administered to the right mPFC caused no significant effects. These results explain how stressed individuals develop maladaptive behaviors through left cortical depression, as reported in mood and anxiety disorders.
authors: Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Korea.|Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Korea.
authors: Eunee
authors: E
authors: Lee
authors: Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Korea.
authors: Jiso
authors: J
authors: Hong
authors: Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Korea.
authors: Young-Gyun
authors: YG
authors: Park
authors: Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
authors: Sujin
authors: S
authors: Chae
authors: Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10065, USA.
authors: Yong
authors: Y
authors: Kim
authors: Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Korea.
authors: Daesoo
authors: D
authors: Kim
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal; D004292:Dominance, Cerebral; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009415:Nerve Net / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012919:Social Behavior; D012920:Social Behavior Disorders / Q000150:complications / Q000503:physiopathology*; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*