title: Significance of Haemodynamic and Haemostatic Factors in the Course of Different Manifestations of Cerebral Small Vessel Disease: The SHEF-CSVD Study-Study Rationale and Protocol.
abstract: Rationale. This paper describes the rationale and design of the SHEF-CSVD Study, which aims to determine the long-term clinical and radiological course of cerebral small vessel disease (CSVD) and to evaluate haemostatic and haemodynamic prognostic factors of the condition. Design. This single-centre, prospective, non-interventional cohort study will follow 150 consecutive patients with different clinical manifestations of CSVD (lacunar ischaemic stroke, vascular dementia, vascular parkinsonism or spontaneous deep, intracerebral haemorrhage) and 50 age- and sex-matched controls over a period of 24 months. The clinical and radiological course will be evaluated basing on a detailed neurological, neuropsychological and MRI examinations. Haemodynamic (cerebral vasoreactivity, 24 h blood pressure control) and haemostatic factors (markers of endothelial and platelet dysfunction, brachial artery flow-mediated dilatation test) will be determined. Discussion. The scheduled study will specifically address the issue of haemodynamic and haemostatic prognostic factors and their course over time in various clinical manifestations of CSVD. The findings may aid the development of prophylactic strategies and individualised treatment plans, which are critical during the early stages of the disease.
authors: Clinic of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Jacek
authors: J
authors: Staszewski
authors: Clinic of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Renata
authors: R
authors: Piusińska-Macoch
authors: Department of Radiology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Ewa
authors: E
authors: Skrobowska
authors: Clinic of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Bogdan
authors: B
authors: Brodacki
authors: Clinic of Ophthalmology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Rafał
authors: R
authors: Pawlik
authors: Department of Radiology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Tomasz
authors: T
authors: Dutkiewicz
authors: Department of Laboratory Medicine, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Wiesław
authors: W
authors: Piechota
authors: Department of Laboratory Medicine, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Alicja
authors: A
authors: Rączka
authors: Clinic of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Kazimierz
authors: K
authors: Tomczykiewicz
authors: Clinic of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors: Adam
authors: A
authors: Stępień