title: Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases.
abstract: Fibroblast growth factor (FGF)19 and FGF21 are hormones that regulate metabolic processes particularly during feeding or starvation, thus ultimately influencing energy production. FGF19 is secreted by the intestines during feeding and negatively regulates bile acid synthesis and secretion, whereas FGF21 is produced in the liver during fasting and plays a crucial role in regulating glucose and lipid metabolism, as well as maintaining energy homeostasis. FGF19 and FGF21 are regarded as late-acting hormones because their functions are only used after insulin and glucagon have completed their actions. Although FGF19 and FGF21 are activated under different conditions, they show extensively functional overlap in terms of improving glucose tolerance, insulin sensitivity, weight loss, and lipid, and energy metabolism, particularly in pathological conditions such as diabetes, obesity, metabolic syndrome, and cardiovascular and renal diseases. Most patients with these metabolic diseases exhibit reduced serum FGF19 levels, which might contribute to its etiology. In addition, the simultaneous increase in serum FGF21 levels is likely a compensatory response to reduced FGF19 levels, and the 2 proteins concertedly maintain metabolic homeostasis. Here, we review the physiological and pharmacological cross talk between FGF19 and FGF21 in relation to the regulation of endocrine metabolism and various chronic diseases.
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Fangfang
authors: F
authors: Zhang
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Lechu
authors: L
authors: Yu
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Xiufei
authors: X
authors: Lin
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Peng
authors: P
authors: Cheng
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Luqing
authors: L
authors: He
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Xiaokun
authors: X
authors: Li
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Xuemian
authors: X
authors: Lu
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Yi
authors: Y
authors: Tan
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Hong
authors: H
authors: Yang
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Lu
authors: L
authors: Cai
authors: Ruian Center of the Chinese-American Research Institute for Diabetic Complications (F.Z., L.Y., X.Lin, P.C., L.H., X.Lu, Y.T., H.Y., L.C., C.Z.), Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325200; Chinese-American Research Institute for Diabetic Complications (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., L.C., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; School of Pharmaceutical Sciences (F.Z., X.Lin, P.C., L.H., X.Li, Y.T., C.Z.), Wenzhou Medical University, Wenzhou, Zhejiang, China 325035; and Department of Pediatrics (Y.T., L.C.), University of Louisville, Louisville, Kentucky 40202.
authors: Chi
authors: C
authors: Zhang
mesh_terms: D052436:Adipose Tissue, White / Q000378:metabolism; D002908:Chronic Disease; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism; D008660:Metabolism
chemical_list: C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors