title: Dysfunction of Rice Mitochondrial Membrane Induced by Yb3+.
abstract: Ytterbium (Yb), a widely used rare earth element, is treated as highly toxic to human being and adverseness to plant. Mitochondria play a significant role in plant growth and development, and are proposed as a potential target for ytterbium toxicity. In this paper, the biological effect of Yb(3+) on isolated rice mitochondria was investigated. We found that Yb(3+) with high concentrations (200 ~ 600 μM) not only induced mitochondrial membrane permeability transition (mtMPT), but also disturbed the mitochondrial ultrastructure. Moreover, Yb(3+) caused the respiratory chain damage, ROS formation, membrane potential decrease, and mitochondrial complex II activity reverse. The results above suggested that Yb(3+) with high concentrations could induce mitochondrial membrane dysfunction. These findings will support some valuable information to the safe application of Yb-based agents.
authors: Department of Chemistry, College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, Hubei, People's Republic of China.
authors: Jia-Ling
authors: JL
authors: Gao
authors: Department of Chemistry, College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, Hubei, People's Republic of China.
authors: Man
authors: M
authors: Wu
authors: Department of Chemistry, College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, Hubei, People's Republic of China.
authors: Wen
authors: W
authors: Liu
authors: Department of Chemistry, College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, Hubei, People's Republic of China.
authors: Zhi-Jiang
authors: ZJ
authors: Feng
authors: Department of Chemistry, College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, Hubei, People's Republic of China.
authors: Ye-Zhong
authors: YZ
authors: Zhang
authors: State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, People's Republic of China.
authors: Feng-Lei
authors: FL
authors: Jiang
authors: Department of Chemistry, College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, Hubei, People's Republic of China.|State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, People's Republic of China.
authors: Yi
authors: Y
authors: Liu
authors: Department of Chemistry, College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, Hubei, People's Republic of China. jiedai1969@126.com.
authors: Jie
authors: http://orcid.org/0000-0003-3478-2170
authors: J
authors: Dai
mesh_terms: D004579:Electron Transport / Q000187:drug effects; D042963:Electron Transport Complex II / Q000378:metabolism; D008560:Membrane Fluidity / Q000187:drug effects; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D051336:Mitochondrial Membranes / Q000378:metabolism*; D012275:Oryza / Q000187:drug effects* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D019802:Succinic Acid / Q000378:metabolism; D015018:Ytterbium / Q000633:toxicity*
chemical_list: D017382:Reactive Oxygen Species; D019802:Succinic Acid; D042963:Electron Transport Complex II; D015018:Ytterbium
keywords: Dysfunction; Isolated mitochondria; Rice; Yb3+