title: Olodaterol + tiotropium bromide for the treatment of chronic obstructive pulmonary disease.
abstract: A solid scientific rationale and an increasing body of clinical evidence for combining a β2-agonist with an antimuscarinic agent in COPD fully support the opinion that patients not controlled by a single bronchodilator should be given two bronchodilators with different mechanisms of action. Tiotropium is an established choice for the management of patients with stable COPD, and olodaterol is a new effective and safe once-daily long-acting β2-agonist. The parallel bronchodilating modes of action of olodaterol and tiotropium make them an attractive combination in COPD. The large ongoing TOviTO Phase III trial program is documenting the efficacy and safety of olodaterol/tiotropium fixed dose combination delivered via the Respimat Soft Mist Inhaler as maintenance therapy in patients with moderate to very severe COPD. However, we must still know whether this fixed-dose combination will affect exacerbations and hospitalizations, and ultimately death, and also the precise estimates of its relative cardiovascular safety.
authors: a 1 Department of Systems Medicine, University of Rome Tor Vergata, Chair of Respiratory Medicine, Rome, Italy.
authors: Mario
authors: M
authors: Cazzola
authors: Paola
authors: P
authors: Rogliani
authors: Josuel
authors: J
authors: Ora
authors: Maria Gabriella
authors: MG
authors: Matera
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D048588:Benzoxazines / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D004338:Drug Combinations; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D000069447:Tiotropium Bromide / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D048588:Benzoxazines; D001993:Bronchodilator Agents; D004338:Drug Combinations; C549647:olodaterol; D000069447:Tiotropium Bromide
keywords: COPD; fixed dose combination; olodaterol; respimat soft mist inhaler; tiotropium bromide