title: [Early cardiotoxicity of Hydroxychloroquine].
abstract: BACKGROUND
  Hydroxychloroquine (HCQ) is most frequently used in the treatment of systemic inflammatory diseases. Cardiac complications of anti-malarial drugs are uncommon, and most of the time are the result of a long-term exposition. In this case, cardiotoxicity is the consequence of the lysosomal dysfunction and the result of intracytoplasmic granular material inclusions.
  
  
  METHODS
  We report a 77-year-old woman who presented a very early and reversible cardiotoxicity, probably related to the quinidine like effect of the HCQ, 10 days after initiation of therapy for Whipple endocarditis.
  
  
  CONCLUSIONS
  We discuss the different mechanisms of cardiotoxicity of anti-malarial drugs and their clinical manifestations.
authors: Service de médecine interne et RECIF, CHU Amiens-Picardie, Amiens, France. Electronic address: yoanz@hotmail.com.
authors: Y
authors: Y
authors: Zerbib
authors: Service de cardiologie, CHU Amiens-Picardie, Amiens, France.
authors: M P
authors: MP
authors: Guillaumont
authors: Service de chirurgie cardiaque, CHU Amiens-Picardie, Amiens, France.
authors: G
authors: G
authors: Touati
authors: Service de médecine interne et RECIF, CHU Amiens-Picardie, Amiens, France; Inserm 1088, université de Picardie-Jules-Verne, Amiens, France.
authors: P
authors: P
authors: Duhaut
authors: Service de médecine interne et RECIF, CHU Amiens-Picardie, Amiens, France; Inserm 1088, université de Picardie-Jules-Verne, Amiens, France.
authors: J
authors: J
authors: Schmidt
mesh_terms: D000368:Aged; D000962:Antimalarials / Q000009:adverse effects*; D066126:Cardiotoxicity; D004697:Endocarditis, Bacterial / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects*; D008061:Whipple Disease / Q000139:chemically induced / Q000473:pathology
chemical_list: D000962:Antimalarials; D006886:Hydroxychloroquine
keywords: Cardiomyopathie; Cardiomyopathy; Cardiotoxicity; Cardiotoxicité; Endocardite; Endocarditis; Hydoxychloroquine; Hydroxychloroquine; Maladie de Whipple; Whipple's disease