title: TMSBr/InBr3-promoted Prins cyclization/homobromination of dienyl alcohol with aldehyde to construct cis-THP containing an exocyclic E-alkene.
abstract: A TMSBr/InBr3-promoted Prins cyclization/homobromination reaction of dienyl alcohol with aldehyde has been developed to construct a unique cis-E THP shown as the A ring in (-)-exiguolide and the B ring in bryostatins.
authors: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China. zhenleisong@scu.edu.cn.
authors: Linjie
authors: L
authors: Li
authors: Xianwei
authors: X
authors: Sun
authors: Yanyang
authors: Y
authors: He
authors: Lu
authors: L
authors: Gao
authors: Zhenlei
authors: Z
authors: Song
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D001966:Bromine / Q000737:chemistry*; D003500:Cyclization; D011714:Pyrans / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000447:Aldehydes; D011714:Pyrans; D001966:Bromine