title: Synthesis and Antihypertensive Action of New Imidazo[1,2-a]pyridine Derivatives , non Peptidic Angiotensin II Receptor Antagonists.
abstract: The synthesis and antihypertensive activity of a group of imidazo[1,2-a]pyridine is described. New synthesized compound have been tested both in vivo and in vitro as antagonists on Angiotensin AT1 receptor, and compared to Losartan, used as reference drug. Binding assay an Angiotensin AT1 receptor were carried on as well. Compounds 6b and 6g showed a potent antihypertensive activity and an high affinity on AT1 receptor.
authors: Dipartimento di Chimica Farmaceutica e Tossicologica, Facolta di Farmacia, Universita di Napoli Federico II, Via D. Montesano, 49, I-80131 Napoli, Italy. slaneri@unina.it.
authors: Sonia
authors: S
authors: Laneri
authors: Cristina
authors: C
authors: Di Ronza
authors: Antonietta
authors: A
authors: Bernardi
authors: Carmine
authors: C
authors: Ostacolo
authors: Antonia
authors: A
authors: Sacchi
authors: Carmela
authors: C
authors: Cervone
authors: Michele
authors: M
authors: D'Amico
authors: Clara
authors: C
authors: Di Filippo
authors: Maria
authors: M
authors: Letizia Trincavelli
authors: Anna
authors: A
authors: Panighini
authors: Claudia
authors: C
authors: Martini
mesh_terms: D057911:Angiotensin Receptor Antagonists / Q000138:chemical synthesis* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D006801:Humans; D008958:Models, Molecular
chemical_list: D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents