title: Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast Cancer.
abstract: There is emerging evidence asserting the importance of orphan nuclear receptors (ONRs) in cancer initiation and progression. In breast cancer, there is a lot unknown about ONRs in terms of their expression profile and their transcriptional targets in the various stages of tumor progression. With the classification of breast tumors into distinct molecular subtypes, we assess ONR expression in the different breast cancer subtypes and with patient outcomes. Complementing this, we review evidence implicating ONR-dependent molecular pathways in breast cancer progression to identify candidate ONRs as potential prognostic markers and/or as therapeutic targets.
authors: Cancer Drug Discovery, Hudson Institute of Medical Research , Melbourne, VIC , Australia ; Department of Biomedicine, University of Bergen , Bergen , Norway.
authors: Reidun
authors: R
authors: Aesoy
authors: Cancer Drug Discovery, Hudson Institute of Medical Research , Melbourne, VIC , Australia ; Department of Molecular and Translational Science, Monash University , Clayton, VIC , Australia.
authors: Colin D
authors: CD
authors: Clyne
authors: Cancer Drug Discovery, Hudson Institute of Medical Research , Melbourne, VIC , Australia ; Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute , Melbourne, VIC , Australia ; School of Cancer Medicine, La Trobe University , Melbourne, VIC , Australia.
authors: Ashwini L
authors: AL
authors: Chand
keywords: breast cancer; breast cancer subtypes; orphan nuclear receptors; small molecule inhibitors; transcription factors