title: The effect of Helicobacter pylori eradication on proteinuria in patients with primary glomerulonephritis.
abstract: BACKGROUND
  Glomerulonephritis is still the primary cause among the diseases causing end stage renal disease. Helicobacter pylori (HP), also having a local proinflammatory effect on gastric mucosa, can trigger a local and systemic inflammatory response, and consequently have a role in the development of extragastrointestinal defects.
  
  
  METHODS
  The study was composed of patients diagnosed with primary glomerulonephritis who had dyspeptic complaints throughout the diagnosis. Patients who received endoscopic biopsy upon the determination of pathologic findings in their upper gastrointestinal endoscopy were HP positive in their biopsy material. A triple eradication therapy was initiated for HP.
  
  
  RESULTS
  The study included 14 female and 19 male patients, 33 in total, whose biopsy material was determined to be HP positive. Before the eradication for HP, we found serum albumin to be 34.0 (19.0-51.0) g/l, serum total protein 58.6 ±12.9 g/l, serum creatinine 0.9 (0.5-1.2) and proteinuria 3069 (652-12392) mg/day in 24-hour urine. After the eradication, however, serum albumin was found to be 40 (20-52) g/l, serum total protein 62.3 ±11.1 g/l, serum creatinine 1.02 (0.6-1.29) mg/dl and proteinuria was 2850 (172-15181) mg/day in 24-hour urine. A comparison of the results showed that a statistically significant difference is established between the serum albumin, total protein and creatinine values (p = 0.001, p = 0.001 and p = 0.021, respectively), but not between proteinuria values in 24-hour urine (p = 0.990).
  
  
  CONCLUSIONS
  Patients with primary glomerulonephritis, HP eradication treatment has an effect on serum albumin levels.
authors: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Fatih
authors: F
authors: Dede
authors: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Deniz
authors: D
authors: Ayli
authors: Department of Pathology, Gazi University, Faculty of Medicine, Ankara, Turkey.
authors: Ipek
authors: I
authors: Gonul
authors: Department of Gastroenterology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Osman
authors: O
authors: Yuksel
authors: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Ramazan
authors: R
authors: Ozturk
authors: Department of Gastroenterology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Ayla
authors: A
authors: Yildiz
authors: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Ezgi
authors: E
authors: Yenigun
authors: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Serhan
authors: S
authors: Piskinpasa
authors: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Didem
authors: D
authors: Turgut
authors: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Eyup
authors: E
authors: Koc
authors: Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Ali Riza
authors: AR
authors: Odabas
keywords: Helicobacter pylori; glomerulonephritis; proteinuria