title: MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer.
abstract: Growing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression of Zinc Finger Transcription Factor 24 (ZNF24). Importantly, upregulation of ZNF24 could re-inhibit miR-940-induced migration and invasion. Hence, we demonstrated the oncogenic role of miR-940 in GC, finding that miR-940 promoted GC progression by directly downregulating ZNF24 expression, and targeting miR-940 could serve as a novel strategy for future GC therapy.
authors: Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China.
authors: Xinyang
authors: X
authors: Liu
authors: Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China.
authors: Xiaoxiao
authors: X
authors: Ge
authors: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China.
authors: Zhe
authors: Z
authors: Zhang
authors: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China.
authors: Xiaowei
authors: X
authors: Zhang
authors: Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China.
authors: Jinjia
authors: J
authors: Chang
authors: Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China.
authors: Zheng
authors: Z
authors: Wu
authors: Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China.
authors: Wenbo
authors: W
authors: Tang
authors: Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China.
authors: Lu
authors: L
authors: Gan
authors: Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China.
authors: Menghong
authors: M
authors: Sun
authors: Department of Medical Oncology, Shanghai Tianyou Hospital of Tongji University, Shanghai, 200032, P.R. China.
authors: Jin
authors: J
authors: Li
mesh_terms: D020413:3' Untranslated Regions; D001665:Binding Sites; D045744:Cell Line, Tumor; D002465:Cell Movement; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D057809:HEK293 Cells; D006801:Humans; D053208:Kaplan-Meier Estimate; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011379:Prognosis; D016016:Proportional Hazards Models; D011485:Protein Binding; D034622:RNA Interference; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D013997:Time Factors; D014162:Transfection
chemical_list: D020413:3' Untranslated Regions; D051741:Kruppel-Like Transcription Factors; C000594732:MIRN940 microRNA, human; D035683:MicroRNAs; C457300:ZNF24 protein, human
keywords: ZNF24; epithelial-mesenchymal transition; gastric cancer; metastasis; miR-940