title: Developing nanocrystals for cancer treatment.
abstract: Nanocrystals are carrier-free solid drug particles that are sized in the nanometer range and have crystalline characteristics. Due to high drug loading (as high as 100%) - free of organic solvents or solubilizing chemicals - nanocrystals have become attractive in the field of drug delivery for cancer treatment. Top-down and bottom-up approaches have been developed for preparing anticancer nanocrystals. In this review, preparation methods and in vivo performance of anticancer nanocrystals are discussed first, followed by an introduction of hybrid nanocrystals in cancer theranostics.
authors: Department of Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.|Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China.
authors: Yi
authors: Y
authors: Lu
authors: Department of Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.|Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
authors: Yan
authors: Y
authors: Chen
authors: Departments of Biopharmaceutical Sciences, Bioengineering & Ophthalmology & Visual Sciences, The University of Illinois, Chicago, IL 60612, USA.
authors: Richard A
authors: RA
authors: Gemeinhart
authors: Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China.
authors: Wei
authors: W
authors: Wu
authors: Department of Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
authors: Tonglei
authors: T
authors: Li
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents
keywords: biodistribution; cancer; formulation; nanocrystals; pharmacokinetics; theranostics