title: Lack of genetic association of the TGM2 gene with schizophrenia in a Chinese population.
abstract: The gene coding for transglutaminase 2 (TGM2) has been reported to be associated with schizophrenia in a White population. The present study was then designed to replicate this initial finding in a Chinese population. A total of 428 individuals with schizophrenia and 555 control participants were recruited for genetic analysis. Four single nucleotide polymorphisms present in the TGM2 gene were selected for genotyping, including rs2076380, rs7270785, rs4811528, and rs6023526, by PCR-based restriction fragment length polymorphism analysis. None of these four single nucleotide polymorphisms genotyped showed an association with schizophrenia, although these 428 cases and 555 controls had 97% power to detect a disease association in small effect size (odds ratio=1.5). The present results did not support the TGM2 association with schizophrenia. It is thus possible that the TGM2 finding may have resulted from a random error of sampling.
authors: aDepartment of Nephrology, Second Hospital of Jilin University bSchool of Public Health & MH Radiobiology Research Unit, Jilin University, Changchun cInstitute of Mental Health, Wenzhou Medical University, Zhejiang, China dCentre for Health Science, Division of Health Research, University of the Highlands & Islands, Inverness, UK.
authors: Jiaxin
authors: J
authors: Wang
authors: Yang
authors: Y
authors: Liu
authors: Zhenqi
authors: Z
authors: Wang
authors: Weili
authors: W
authors: Du
authors: Li
authors: L
authors: Hui
authors: Xinli
authors: X
authors: Zhao
authors: Xiaoxia
authors: X
authors: Zhao
authors: Xuan
authors: X
authors: Zhang
authors: Jun
authors: J
authors: Wei
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012559:Schizophrenia / Q000235:genetics*; D011503:Transglutaminases / Q000235:genetics*
chemical_list: C000717608:TGM2 protein, human; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins