title: Multifaceted roles of adiponectin in rheumatoid arthritis.
abstract: Adiponectin is a circulating hormone with pleiotropic functions in lipid and glucose metabolism secreted by adipocytes. It plays a beneficial role in cardiovascular functions and metabolic complications. Recently, growing researches have elucidated that increased adiponectin plasma levels correlate with severity of rheumatoid arthritis (RA) and it is speculative that adiponectin may link to RA. The association of adiponectin with potential inflammatory functions in RA has raised significant interests in exploring this adipokine as a target for RA-diagnostic and therapeutic applications. Despite significant advances in understanding adiponectin functions and signaling mechanisms, its roles in RA remain multifaceted and subject to controversy. This review highlights the evidences linking adiponectin to either anti-inflammatory or pro-inflammatory action in RA. The results of this review may provide important insight into adiponectin in the development of RA.
authors: Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
authors: Ding
authors: D
authors: Liu
authors: Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
authors: Shuaihantian
authors: S
authors: Luo
authors: Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address: xyeyygbzk@163.com.
authors: Zhihong
authors: Z
authors: Li
mesh_terms: D017667:Adipocytes / Q000502:physiology*; D052242:Adiponectin / Q000378:metabolism* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000188:drug therapy; D015415:Biomarkers / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D050356:Lipid Metabolism
chemical_list: D052242:Adiponectin; D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D018836:Inflammation Mediators; D005947:Glucose
keywords: Adiponectin; Anti- inflammatory; Biomarker; Pro-inflammatory; Rheumatoid arthritis