title: Gender-Specific Associations of Serum Insulin-Like Growth Factor-1 With Bone Health and Fractures in Older Persons.
abstract: BACKGROUND
  IGF-1 plays a role in bone metabolism. Although IGF-1 and bone mass both decrease with advancing age, their relationship in older individuals remains to be elucidated.
  
  
  OBJECTIVE
  The objective was to investigate associations of serum IGF-1 cross-sectionally with quantitative ultrasound and bone mineral density (BMD), and longitudinally with 3-year change in BMD and 10-year fracture risk in older individuals.
  
  
  METHODS
  The study included 627 men and 656 women aged ≥ 65 years from the Longitudinal Aging Study Amsterdam, an ongoing, population-based cohort study.
  
  
  METHODS
  Main outcome measures included baseline serum IGF-1 concentration; baseline quantitative ultrasound of the heel, including broadband ultrasound attenuation and speed of sound; BMD measured at several body sites at baseline and after 3 years; and prospective fracture incidence over 10 years. Associations were adjusted for relevant confounders.
  
  
  RESULTS
  Women, but not men, in the lowest quintile of IGF-1 concentration had lower broadband ultrasound attenuation (B = -4.53; P = .03) and a greater 3-year decrease in total hip BMD (B = -0.02; P = .05), than women in the highest quintile of IGF-1. Moreover, compared to women in the highest quintile of IGF-1, women in the combined lowest four quintiles of IGF-1 had an increased 10-year fracture risk (hazard ratio = 1.98; P = .05).
  
  
  CONCLUSIONS
  Associations of lower IGF-1 with lower BUA, greater 3-year decrease in BMD, and increased 10-year fracture risk were only observed in women, not in men. These results support previous findings of gender differences in the relationship between IGF-1 and bone in older individuals.
authors: Department of Internal Medicine, Endocrine Section (N.C.v.V., M.L.D., P.L.), and Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research (E.S.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
authors: N C
authors: NC
authors: van Varsseveld
authors: Department of Internal Medicine, Endocrine Section (N.C.v.V., M.L.D., P.L.), and Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research (E.S.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
authors: E
authors: E
authors: Sohl
authors: Department of Internal Medicine, Endocrine Section (N.C.v.V., M.L.D., P.L.), and Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research (E.S.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
authors: M L
authors: ML
authors: Drent
authors: Department of Internal Medicine, Endocrine Section (N.C.v.V., M.L.D., P.L.), and Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research (E.S.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
authors: P
authors: P
authors: Lips
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000502:physiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D050723:Fractures, Bone / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009426:Netherlands / Q000453:epidemiology; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D018570:Risk Assessment; D012727:Sex Characteristics; D014463:Ultrasonography
chemical_list: D007334:Insulin-Like Growth Factor I