title: Elevation of the maxillary sinus membrane for de-novo bone formation: First results of a prospective study in humans.
abstract: OBJECTIVE
  Sinus floor elevation via the lateral window approach represents a reliable technique for bone augmentation in the atrophic posterior maxilla. It is known that sinus membrane elevation leads to new bone formation. This prospective clinical study compared a specific technique in sinus membrane elevation with a conventional sinus floor augmentation (xenogenous/autogenous bone) in a human split mouth model.
  
  
  METHODS
  Five edentulous patients with highly atrophic posterior maxillae were included in this study. On one maxillary side a degradable PDLLA-membrane was placed to create a space underneath the sinus membrane. Contralateral a mixture of autogenous and xenogenous bone was used for sinus floor augmentation. A two-stage procedure was carried out. The following variables were assessed: bone regeneration on cone-beam computed tomography (cone-beam CT), implant success, prosthetic comfort and patient satisfaction. Bone biopsies were taken with simultaneous implant placement. The samples were histologically analyzed.
  
  
  RESULTS
  Cone-beam CTs revealed new bone formation on both sides. Thirty implants were placed, 15 in the augmented region and 15 in the non-augmented side. Thirty bone biopsies were taken and evaluated. Vital new bone was detected on the experimental side (osteoinductivity). On the conventional side a mixture of autogenous and residual bone substitute material was seen (osteoconductivity). Implant survival was 100% so far. Patient's satisfaction was high and prosthetic complications were not encountered.
  
  
  CONCLUSIONS
  As it provides the highest rate of bone formation, autogenous bone in combination with bone substitute material can be considered as a very reliable standard procedure in sinus floor augmentation. The specific sinus membrane elevation technique as presented here showed satisfying results and might be a suitable alternative for maxillary sinus augmentation.
authors: Department of Cranio-Maxillofacial Surgery (Head: Prof. P. Kessler), Maastricht Univesity Medical Center, Maastricht, The Netherlands. Electronic address: suen.lie@mumc.nl.
authors: Nynke
authors: N
authors: Lie
authors: Department of Orthodontics, Hannover Medical School, Hannover, Germany.
authors: Hans-Albert
authors: HA
authors: Merten
authors: Department of Cranio-Maxillofacial Surgery (Head: Prof. P. Kessler), Maastricht Univesity Medical Center, Maastricht, The Netherlands.
authors: Joeri
authors: J
authors: Meyns
authors: Department of Oral-Maxillofacial Surgery, University of Aachen, Aachen, Germany.
authors: Bernd
authors: B
authors: Lethaus
authors: Department of Oral-Maxillofacial Surgery (Head: Prof. J. Wiltfang), University of Kiel, Kiel, Germany.
authors: Jörg
authors: J
authors: Wiltfang
authors: Department of Cranio-Maxillofacial Surgery (Head: Prof. P. Kessler), Maastricht Univesity Medical Center, Maastricht, The Netherlands.
authors: Peter
authors: P
authors: Kessler
mesh_terms: D020341:Absorbable Implants; D064592:Autografts / Q000637:transplantation; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods; D054893:Cone-Beam Computed Tomography / Q000379:methods; D015921:Dental Implants; D005500:Follow-Up Studies; D048091:Guided Tissue Regeneration / Q000379:methods*; D064593:Heterografts / Q000637:transplantation; D006801:Humans; D007575:Jaw, Edentulous / Q000601:surgery; D008443:Maxillary Sinus / Q000601:surgery*; D008567:Membranes, Artificial; D009297:Nasal Mucosa / Q000601:surgery*; D010012:Osteogenesis / Q000502:physiology*; D017060:Patient Satisfaction; D010865:Pilot Projects; D011091:Polyesters / Q000737:chemistry; D011446:Prospective Studies; D059546:Sinus Floor Augmentation / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D015921:Dental Implants; D008567:Membranes, Artificial; D011091:Polyesters; C033616:poly(lactide)
keywords: Guided bone regeneration; Osteoinduction; Sinus floor augmentation