title: [IMPACT OF DIETARY FATTY ACIDS ON LIPID PROFILE, INSULIN SENSITIVITY AND FUNCTIONALITY OF PANCREATIC β CELLS IN TYPE 2 DIABETIC SUBJECTS].
abstract: BACKGROUND
  the quality of fats could influence the metabolic control of patients with Type 2 Diabetes Mellitus (DM2).
  
  
  OBJECTIVE
  to determine the relationship between intake and quality of dietary fatty acids to lipid profile, metabolic control, functionality of pancreatic cells and insulin sensivity in subjects with DM2.
  
  
  METHODS
  we studied 54 subjects with DM2, anthropometric measurements were performed, body composition and dietary lipid intake, saturated fatty acids (SFA), trans, monounsaturated, polyunsaturated, omega 3, omega 6 and dietary cholesterol. Laboratory parameters related to their metabolic control were determined (fasting blood glucose, glycated hemoglobin, and lipid profile). The insulin secretion and insulin sensitivity was determined with the insulin-modified intravenous glucose tolerance test according to the Bergman's minimal model.
  
  
  RESULTS
  28 men and 26 women were studied (BMI of 29.5 ± 3.7 kg/m2; age 55.6 ± 6.8 y.), 48% had LDL-C < 100 mg/dL, 12.9% of men c-HDL > 40 mg/dL and 7.4% of women c-HDL > 50 mg/dL. 32% consumed > 10% of AGS and > 300 mg/day of dietary cholesterol. The SFA intake and percentage of calories from fat (G%) were significantly associated with insulin resistance and fasting plasma glucose concentration. The G% predicted 84% variability on c-VLDL.
  
  
  CONCLUSIONS
  in patients with DM2 a greater intake of fat and saturated fatty acids it associated with greater fasting glycemia and insulin resistance.
authors: Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago (Chile).. projasmon@gmail.com.
authors: Verónica
authors: V
authors: Sambra Vásquez
authors: Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago (Chile).. projasmon@gmail.com.
authors: Pamela
authors: P
authors: Rojas Moncada
authors: Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago (Chile).. projasmon@gmail.com.
authors: Karen
authors: K
authors: Basfi-Fer
authors: Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago (Chile).. projasmon@gmail.com.
authors: Alejandra
authors: A
authors: Valencia
authors: Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago (Chile).. projasmon@gmail.com.
authors: Juana
authors: J
authors: Codoceo
authors: Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago (Chile).. projasmon@gmail.com.
authors: Jorge
authors: J
authors: Inostroza
authors: Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago (Chile).. projasmon@gmail.com.
authors: Fernando
authors: F
authors: Carrasco
authors: Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago (Chile).. projasmon@gmail.com.
authors: Manuel
authors: M
authors: Ruz Ortiz
mesh_terms: D015415:Biomarkers; D001786:Blood Glucose; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D004041:Dietary Fats; D002149:Energy Intake; D005215:Fasting; D005227:Fatty Acids; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids