title: Assessment of the Mechanistic Role of Cinnarizine in Modulating Experimentally-Induced Bronchial Asthma in Rats.
abstract: OBJECTIVE
  Calcium influx, inflammatory infiltration, cytokine production, immunoglobulin E activation and oxidative stress play coordinated roles in bronchial asthma pathogenesis. We aim to assess the protective effect of cinnarizine against experimentally induced bronchial asthma.
  
  
  METHODS
  Bronchial asthma was induced by ovalbumin sensitization and challenge. Rats were allocated into a normal control, an asthma control, a dexamethasone (standard) treatment, and 2 cinnarizine treatment groups. The respiratory functions tidal volume (TV) and peak expiratory flow rate (PEFR), the inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-5 (IL-5) in lung tissue, the allergic immunoglobulin IgE in serum, the absolute eosinophil count (AEC) in bronchoalveolar lavage fluid (BALF), as well as the oxidative and nitrosative markers glutathione reduced (GSH) and superoxide dismutase (SOD) in lung tissue and nitric oxide end products (NOx) in BALF were assessed, followed by a histopathological study.
  
  
  RESULTS
  Cinnarizine administration significantly restored TV, PEFR, TNF-α, IL-5, IgE, AEC, GSH, SOD and NOx values back to normal levels, and significantly decreased perivascular and peribronchiolar inflammatory scores.
  
  
  CONCLUSIONS
  Cinnarizine may protect against experimental bronchial asthma. Suppressant effect of cinnarizine on pro-inflammatory cytokines release, IgE antibody production, eosinophil infiltration as well as oxidative and nitrosative stress may explain its anti-asthmatic potential.
authors: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
authors: Maha M
authors: MM
authors: Abdel-Fattah
authors: Basim A S
authors: BA
authors: Messiha
authors: Abeer A A
authors: AA
authors: Salama
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002936:Cinnarizine / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D003907:Dexamethasone / Q000627:therapeutic use; D015848:Interleukin-5 / Q000097:blood; D008168:Lung / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D010047:Ovalbumin / Q000276:immunology; D018384:Oxidative Stress / Q000187:drug effects; D010366:Peak Expiratory Flow Rate; D051381:Rats; D026361:Reactive Nitrogen Species / Q000378:metabolism; D013990:Tidal Volume; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018927:Anti-Asthmatic Agents; D016207:Cytokines; D015848:Interleukin-5; D026361:Reactive Nitrogen Species; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D002936:Cinnarizine; D003907:Dexamethasone; D010047:Ovalbumin