title: HINT1 is involved in the behavioral abnormalities induced by social isolation rearing.
abstract: Social isolation (SI) rearing has been demonstrated to induce behavioral abnormalities like anxiety, impulsivity, aggression, and learning and memory deficits which are relevant to core symptoms in patients with some certain neuropsychiatric disorders. But the underlying pathophysiological mechanisms remain unclear. Recent studies have revealed HINT1 has close relation with diverse neuropsychiatric diseases. In this present study, the SI rearing mice exhibited depression-like and aggressive behavior. Besides, HINT1 protein levels decreased in PFC but increased in HIP. Based on the data obtained, we concluded that HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions.
authors: College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China; Key Laboratory of the Health Ministry for Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China; Key Laboratory of Environment and Genes Related to Diseases of the Education Ministry, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors: Yong-Hui
authors: YH
authors: Dang
authors: College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors: Peng
authors: P
authors: Liu
authors: Department of Psychiatry, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors: Rui
authors: R
authors: Ma
authors: College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors: Zheng
authors: Z
authors: Chu
authors: Zong Lian College, Xi'an Jiaotong University, Xi'an 710061, China.
authors: You-Ping
authors: YP
authors: Liu
authors: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltiore, Baltimore, MD 21201, USA.
authors: Jia-Bei
authors: JB
authors: Wang
authors: Department of Psychiatry, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. Electronic address: maxiancang@163.com.
authors: Xian-Cang
authors: XC
authors: Ma
authors: Department of Psychiatry, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. Electronic address: yaogaow@163.com.
authors: Cheng-Ge
authors: CG
authors: Gao
mesh_terms: D000374:Aggression; D000818:Animals; D001007:Anxiety / Q000523:psychology; D001522:Behavior, Animal; D003863:Depression / Q000523:psychology; D006624:Hippocampus / Q000378:metabolism; D007858:Learning; D008297:Male; D008568:Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000378:metabolism; D012934:Social Isolation
chemical_list: C489275:Hint1 protein, mouse; D009419:Nerve Tissue Proteins
keywords: Aggressive behavior; HINT1; Hippocampus; Prefrontal cortex; Social isolation