title: Multiscale Control of Hierarchical Structure in Crystalline Block Copolymer Nanoparticles Using Microfluidics.
abstract: Hierarchical semicrystalline block copolymer nanoparticles are produced in a segmented gas-liquid microfluidic reactor with top-down control of multiscale structural features, including nanoparticle morphologies, sizes, and internal crystallinities. Control of multiscale structure on disparate length scales by a single control variable (flow rate) enables tailoring of drug delivery nanoparticle function including release rates.
authors: Department of Chemistry, University of Victoria, P.O. Box 3065, Victoria, BC, V8W 3V6, Canada.
authors: Aman
authors: A
authors: Bains
authors: Department of Chemistry, University of Victoria, P.O. Box 3065, Victoria, BC, V8W 3V6, Canada.
authors: Yimeng
authors: Y
authors: Cao
authors: Department of Chemistry, University of Victoria, P.O. Box 3065, Victoria, BC, V8W 3V6, Canada.
authors: Matthew G
authors: MG
authors: Moffitt
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D003460:Crystallization; D004126:Dimethylformamide / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D044085:Microfluidics / Q000295:instrumentation / Q000379:methods*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017239:Paclitaxel / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D011091:Polyesters; D012996:Solutions; C458722:polyethylene oxide-polycaprolactone copolymer; D014867:Water; D004126:Dimethylformamide; D017239:Paclitaxel
keywords: block copolymers; drug delivery; microfluidics; nanoparticles; self-assembly