title: [Effects of blood flow properties on ocular hemodynamics].
abstract: OBJECTIVE
  to study the effects of blood rheology on ocular blood flow (OBF) parameters and estimated individual normal range of intraocular pressure (IOP).
  
  
  METHODS
  A total of 15 patients (15 eyes) taking warfarin were enrolled. Volumetric parameters and linear velocity of OBF under warfarin treatment and after its cessation were obtained by means of flowmetry (Paradigm's Blood Flow Analyzer) and color Doppler flow mapping (Voluson 730), respectively. On the basis of flowmetry results an individual normal range of IOP was calculated in all patients.
  
  
  RESULTS
  Pulsatile OBF does not appear to correlate with warfarin-induced changes in blood rheology (p = 0.09), however, depends on IOP fluctuations (p = 0.02). Resistance index of retinal vessels is found to rise significantly with increasing blood viscosity (p < 0.05).
  
  
  CONCLUSIONS
  The use of warfarin, an indirect thrombin inhibitor, has no effect on estimated individual normal range of IOP, which is crucial for glaucoma diagnosis and monitoring.
authors: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
authors: V R
authors: VR
authors: Mamikonyan
authors: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
authors: N S
authors: NS
authors: Galoyan
authors: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
authors: E E
authors: EE
authors: Kazaryan
authors: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
authors: S I
authors: SI
authors: Kharlap
authors: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
authors: O A
authors: OA
authors: Shmeleva-Demir
authors: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
authors: D V
authors: DV
authors: Andzhelova
authors: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
authors: A A
authors: AA
authors: Rafaelyan
authors: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
authors: T A
authors: TA
authors: Kakunina
mesh_terms: D005123:Eye / Q000098:blood supply*; D005901:Glaucoma / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D012039:Regional Blood Flow / Q000502:physiology*; D012171:Retinal Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018615:Ultrasonography, Doppler, Color; D014655:Vascular Resistance