title: Precision medicine at Memorial Sloan Kettering Cancer Center: clinical next-generation sequencing enabling next-generation targeted therapy trials.
abstract: Implementing a center-wide precision medicine strategy at a major cancer center is a true multidisciplinary effort and requires comprehensive alignment of a broad screening strategy with a clinical research enterprise that can use these data to accelerate development of new treatments. Here, we describe the genomic screening approach at Memorial Sloan Kettering Cancer Center, a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology designated MSK-IMPACT, and how it enables and supports a large clinical trial portfolio enriched for multi-histology, biomarker-selected, 'basket' studies of targeted therapies.
authors: Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, USA; Weill Cornell Medical College, NY, USA.
authors: David M
authors: DM
authors: Hyman
authors: Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, USA; Weill Cornell Medical College, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, NY, USA; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, NY, USA.
authors: David B
authors: DB
authors: Solit
authors: Department of Pathology, Memorial Sloan Kettering Cancer Center, NY, USA.
authors: Maria E
authors: ME
authors: Arcila
authors: Department of Pathology, Memorial Sloan Kettering Cancer Center, NY, USA.
authors: Donavan T
authors: DT
authors: Cheng
authors: Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, USA; Weill Cornell Medical College, NY, USA.
authors: Paul
authors: P
authors: Sabbatini
authors: Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, USA; Weill Cornell Medical College, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, NY, USA.
authors: Jose
authors: J
authors: Baselga
authors: Weill Cornell Medical College, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, NY, USA; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, NY, USA.
authors: Michael F
authors: MF
authors: Berger
authors: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, NY, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, NY, USA. Electronic address: ladanyim@mskcc.org.
authors: Marc
authors: M
authors: Ladanyi
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D057285:Precision Medicine / Q000379:methods