title: Prevalence of Peripheral Eosinophilia at Diagnosis in Children With Inflammatory Bowel Disease.
abstract: OBJECTIVE
  Inflammatory bowel disease (IBD) encompasses 2 disorders of unknown etiology: Crohn disease (CD) and ulcerative colitis (UC). There has been a continuous search for markers for disease activity. Eosinophils are granulocytic leukocytes that are implicated in the pathogenesis of IBD. The aim of this study was to examine the prevalence and significance of peripheral eosinophilia (PE) at diagnosis in children with IBD.
  
  
  METHODS
  A comprehensive chart review of all children with diagnosed as having IBD between January 2006 and August 2014 was performed. Patients with PE at diagnosis were compared with those without in relation to disease clinical activity and disease course.
  
  
  RESULTS
  A total of 109 children (mean age 14.6 ± 2.77, range 4.5-17.9 years, 55 boys) with IBD (68 with CD and 41 with UC) who were studied for a mean duration of 2.82 ± 1.89 (range 0.1-9.2 years) were identified. At diagnosis, 44 (40.4%) children had PE, which was more prevalent in patients with UC compared with those with CD (61.3% vs 36.3%, P < 0.05). At diagnosis, PE was more common in patients with high eosinophilic count in colonic biopsy samples (P < 0.01) and was significantly associated with disease activity as indicated by Pediatric CD Activity Index for children with CD (P < 0.05), Pediatric UC Activity Index for children with UC (P < 0.01).
  
  
  CONCLUSIONS
  PE is a common finding at diagnosis in children with IBD especially in those with UC. Patients with PE at diagnosis are more likely to present with higher clinical activity indices. PE is associated with more eosinophils in colonic biopsy samples.
authors: *Sections of Pediatric Gastroenterology, Departments of Pediatrics †Department of Pathology ‡Department of Pediatric, George and Fay Yee Center for Healthcare Innovation of Pediatric Hematology §College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
authors: Geetanjalee
authors: G
authors: Sadi
authors: Qi
authors: Q
authors: Yang
authors: Brenden
authors: B
authors: Dufault
authors: Camelia
authors: C
authors: Stefanovici
authors: Jayson
authors: J
authors: Stoffman
authors: Wael
authors: W
authors: El-Matary
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D003113:Colonoscopy; D003424:Crohn Disease / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D004751:Enteritis / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D004802:Eosinophilia / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D004804:Eosinophils / Q000276:immunology / Q000473:pathology*; D005260:Female; D005756:Gastritis / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D006776:Hospitals, Pediatric; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology*; D008297:Male; D008350:Manitoba / Q000453:epidemiology; D015995:Prevalence; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers