title: DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.
abstract: DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retroviral sequences.
authors: Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Lurie 5-123, Chicago, IL 60611, USA. Electronic address: j-licht@northwestern.edu.
authors: Jonathan D
authors: JD
authors: Licht
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D001374:Azacitidine / Q000031:analogs & derivatives*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D019175:DNA Methylation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000276:immunology*; D008545:Melanoma / Q000276:immunology* / Q000628:therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D007370:Interferon Type I; D001374:Azacitidine