title: DNA Repair Is Associated with Information Content in Bacteria, Archaea, and DNA Viruses.
abstract: The concept of a "proteomic constraint" proposes that DNA repair capacity is positively correlated with the information content of a genome, which can be approximated to the size of the proteome (P). This in turn implies that DNA repair genes are more likely to be present in genomes with larger values of P. This stands in contrast to the common assumption that informational genes have a core function and so are evenly distributed across organisms. We examined the presence/absence of 18 DNA repair genes in bacterial genomes. A positive relationship between gene presence and P was observed for 17 genes in the total dataset, and 16 genes when only nonintracellular bacteria were examined. A marked reduction of DNA repair genes was observed in intracellular bacteria, consistent with their reduced value of P. We also examined archaeal and DNA virus genomes, and show that the presence of DNA repair genes is likewise related to a larger value of P. In addition, the products of the bacterial genes mutY, vsr, and ndk, involved in the correction of GC/AT mutations, are strongly associated with reduced genome GC content. We therefore propose that a reduction in information content leads to a loss of DNA repair genes and indirectly to a reduction in genome GC content in bacteria by exposure to the underlying AT mutation bias. The reduction in P may also indirectly lead to the increase in substitution rates observed in intracellular bacteria via loss of DNA repair genes.
authors: From the Department of Biology, University of Puerto Rico-Rio Piedras, PO Box 23360, San Juan 00931, Puerto Rico (Acosta, Carela, Garcia-Gonzalez, Gines, Vicens, Cruet, and Massey).
authors: Sharlene
authors: S
authors: Acosta
authors: From the Department of Biology, University of Puerto Rico-Rio Piedras, PO Box 23360, San Juan 00931, Puerto Rico (Acosta, Carela, Garcia-Gonzalez, Gines, Vicens, Cruet, and Massey).
authors: Miguelina
authors: M
authors: Carela
authors: From the Department of Biology, University of Puerto Rico-Rio Piedras, PO Box 23360, San Juan 00931, Puerto Rico (Acosta, Carela, Garcia-Gonzalez, Gines, Vicens, Cruet, and Massey).
authors: Aurian
authors: A
authors: Garcia-Gonzalez
authors: From the Department of Biology, University of Puerto Rico-Rio Piedras, PO Box 23360, San Juan 00931, Puerto Rico (Acosta, Carela, Garcia-Gonzalez, Gines, Vicens, Cruet, and Massey).
authors: Mariela
authors: M
authors: Gines
authors: From the Department of Biology, University of Puerto Rico-Rio Piedras, PO Box 23360, San Juan 00931, Puerto Rico (Acosta, Carela, Garcia-Gonzalez, Gines, Vicens, Cruet, and Massey).
authors: Luis
authors: L
authors: Vicens
authors: From the Department of Biology, University of Puerto Rico-Rio Piedras, PO Box 23360, San Juan 00931, Puerto Rico (Acosta, Carela, Garcia-Gonzalez, Gines, Vicens, Cruet, and Massey).
authors: Ricardo
authors: R
authors: Cruet
authors: From the Department of Biology, University of Puerto Rico-Rio Piedras, PO Box 23360, San Juan 00931, Puerto Rico (Acosta, Carela, Garcia-Gonzalez, Gines, Vicens, Cruet, and Massey). stevenemassey@gmail.com.
authors: Steven E
authors: SE
authors: Massey
mesh_terms: D001105:Archaea / Q000235:genetics; D001419:Bacteria / Q000235:genetics*; D001482:Base Composition; D016000:Cluster Analysis; D004260:DNA Repair; D004267:DNA Viruses / Q000235:genetics; D019143:Evolution, Molecular; D019766:Genes, Archaeal; D005798:Genes, Bacterial; D005814:Genes, Viral; D016680:Genome, Bacterial; D059645:Mutation Rate; D010802:Phylogeny; D020543:Proteome
chemical_list: D020543:Proteome
keywords: DNA repair; GC content; genome size; information content; proteomic constraint