title: In vivo determination of aluminum, cobalt, chromium, copper, nickel, titanium and vanadium in oral mucosa cells from orthodontic patients with mini-implants by Inductively coupled plasma-mass spectrometry (ICP-MS).
abstract: Miniscrews are used as orthodontic anchorage devices in the dentistry clinical practice but the in vivo metallic release from these structures has been not previously investigated. The aim of this study was to determine the content of Al, Co, Cr, Cu, Ni, Ti and V in oral mucosa cells of control subjects, patients under orthodontic treatment and with both, orthodontic treatment and miniscrew, in order to know the contribution of these mini-implants to the total metallic content. ICP-MS measurements revealed the following ascending order: Cr<Ni<Ti<Cu<Al, and Co and V were practically undetected. Significant differences in comparison to the control group were found for Cu in the orthodontic group, and for Ni in both, orthodontic and orthodontic+miniscrew groups. Potential correlations among metallic elements and with some clinical factors were also explored. These findings suggest that miniscrews do not increase significantly the metal release.
authors: Stomatology Department, School of Dentistry, University of Seville, Spain.
authors: Ana
authors: A
authors: Martín-Cameán
authors: Area of Toxicology, Faculty of Pharmacy, University of Seville, Spain.
authors: Angeles
authors: A
authors: Jos
authors: Area of Toxicology, Faculty of Pharmacy, University of Seville, Spain.
authors: Maria
authors: M
authors: Puerto
authors: Investigation, Technology and Innovation Center, University of Seville, Spain.
authors: Ana
authors: A
authors: Calleja
authors: Stomatology Department, School of Dentistry, University Complutense of Madrid, Spain.
authors: Alejandro
authors: A
authors: Iglesias-Linares
authors: Stomatology Department, School of Dentistry, University of Seville, Spain.
authors: Enrique
authors: E
authors: Solano
authors: Area of Toxicology, Faculty of Pharmacy, University of Seville, Spain. Electronic address: camean@us.es.
authors: Ana M
authors: AM
authors: Cameán
mesh_terms: D000293:Adolescent; D000328:Adult; D000535:Aluminum / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D002857:Chromium / Q000032:analysis; D003035:Cobalt / Q000032:analysis; D003300:Copper / Q000032:analysis; D015921:Dental Implants; D006801:Humans; D007477:Ions; D057230:Limit of Detection; D016014:Linear Models; D013058:Mass Spectrometry; D008670:Metals / Q000032:analysis*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000166:cytology*; D009532:Nickel / Q000032:analysis; D009970:Orthodontics; D014639:Vanadium / Q000032:analysis; D055815:Young Adult
chemical_list: D015921:Dental Implants; D007477:Ions; D008670:Metals; D014639:Vanadium; D002857:Chromium; D003035:Cobalt; D003300:Copper; D009532:Nickel; D000535:Aluminum
keywords: In vivo; Metals; Miniscrew; Oral mucosa cells; Orthodontic