title: Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells.
abstract: We synthesized new vitamin K2 analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K2.
authors: Department of Bioscience and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology , 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan.
authors: Yoshitomo
authors: Y
authors: Suhara
authors: Department of Hygienic Sciences, Kobe Pharmaceutical University , 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
authors: Yoshihisa
authors: Y
authors: Hirota
authors: Department of Chemistry, Faculty of Science, Rikkyo University , 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan.
authors: Norika
authors: N
authors: Hanada
authors: Laboratory of Environmental Sciences, Yokohama College of Pharmacy , 601 Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan.
authors: Shun
authors: S
authors: Nishina
authors: Laboratory of Environmental Sciences, Yokohama College of Pharmacy , 601 Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan.
authors: Sachiko
authors: S
authors: Eguchi
authors: Department of Bioscience and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology , 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan.
authors: Rie
authors: R
authors: Sakane
authors: Department of Hygienic Sciences, Kobe Pharmaceutical University , 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
authors: Kimie
authors: K
authors: Nakagawa
authors: Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University , 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
authors: Akimori
authors: A
authors: Wada
authors: Laboratory of Environmental Sciences, Yokohama College of Pharmacy , 601 Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan.
authors: Kazuhiko
authors: K
authors: Takahashi
authors: Department of Chemistry, Faculty of Science, Rikkyo University , 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan.
authors: Hiroaki
authors: H
authors: Tokiwa
authors: Department of Hygienic Sciences, Kobe Pharmaceutical University , 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
authors: Toshio
authors: T
authors: Okano
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology / Q000187:drug effects*; D019579:Neocortex / Q000166:cytology; D058953:Neural Stem Cells / Q000166:cytology / Q000187:drug effects*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D024482:Vitamin K 2 / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D024482:Vitamin K 2