title: The relationship between eosinophilia and slow coronary flow.
abstract: OBJECTIVE
  The pathophysiology of slow coronary flow (SCF) involves atherosclerosis, small vessel dysfunction, platelet function disorders, and inflammation. It has been known that eosinophils also play a significant role in inflammation, vasoconstriction, thrombosis, and endothelial dysfunction. We propose to evaluate the relationship between eosinophilia and SCF.
  
  
  METHODS
  All patients who underwent coronary angiography between January 2011 and December 2013 were screened retrospectively. Of 6,832 patients, 102 patients with SCF (66 males, mean age 52.2±11.7 years) and 77 control subjects with normal coronary angiography (50 males, mean age 50.7±8.1 years) were detected. Baseline characteristics, hematological test results, and biochemical test results were obtained from the hospital database.
  
  
  RESULTS
  Baseline characteristics of the study groups were comparable between groups. There was no significant difference between groups regarding leukocyte count, paletelet count, and mean platelet volume. However, patients with SCF had a higher eosinophil count than the controls (0.24±0.17×10(3)/μL vs 0.16±0.15×10(3)/μL, P=0.002). In addition, eosinophil count was found to be correlated with thrombolysis in myocardial infarction (TIMI) frame count in the SCF group (r=0.3, P<0.01). There was no significant correlation between eosinophil count and the number of coronary arteries showing slow flow.
  
  
  CONCLUSIONS
  Patients with SCF have higher blood eosinophil count, and this may play an important role in the pathogenesis of SCF. Elevated baseline eosinophil count may indicate the presence of SCF.
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Yakup
authors: Y
authors: Altas
authors: Department of Cardiology, Malatya State Hospital, Malatya, Turkey.
authors: Ertugrul
authors: E
authors: Kurtoglu
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Baris
authors: B
authors: Yaylak
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Erkan
authors: E
authors: Baysal
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Berzal
authors: B
authors: Ucaman
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Hasan Murat
authors: HM
authors: Ugurlu
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Mehmet Zülkif
authors: MZ
authors: Karahan
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Bernas
authors: B
authors: Altintas
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Mehmet Sahin
authors: MS
authors: Adiyaman
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: İlyas
authors: İ
authors: Kaya
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Umut
authors: U
authors: Erdolu
authors: Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
authors: Kaya
authors: K
authors: Ozen
authors: Department of Cardiology, Memorial Diyarbakir Hospital, Diyarbakir, Turkey.
authors: Cayan
authors: C
authors: Cakir
authors: Department of Cardiovascular Surgery, Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
authors: Utkan
authors: U
authors: Sevuk
keywords: coronary angiography; eosinophilia; slow coronary flow