title: Regional Homogeneity of Resting-State Brain Activity Suppresses the Effect of Dopamine-Related Genes on Sensory Processing Sensitivity.
abstract: Sensory processing sensitivity (SPS) is an intrinsic personality trait whose genetic and neural bases have recently been studied. The current study used a neural mediation model to explore whether resting-state brain functions mediated the effects of dopamine-related genes on SPS. 298 healthy Chinese college students (96 males, mean age = 20.42 years, SD = 0.89) were scanned with magnetic resonance imaging during resting state, genotyped for 98 loci within the dopamine system, and administered the Highly Sensitive Person Scale. We extracted a "gene score" that summarized the genetic variations representing the 10 loci that were significantly linked to SPS, and then used path analysis to search for brain regions whose resting-state data would help explain the gene-behavior association. Mediation analysis revealed that temporal homogeneity of regional spontaneous activity (ReHo) in the precuneus actually suppressed the effect of dopamine-related genes on SPS. The path model explained 16% of the variance of SPS. This study represents the first attempt at using a multi-gene voxel-based neural mediation model to explore the complex relations among genes, brain, and personality.
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China.
authors: Chunhui
authors: C
authors: Chen
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China; Institute of Psychology, Division of Psychopathology and Clinic Intervention, University of Zurich, Zurich, CH-8050, Switzerland.
authors: Daiming
authors: D
authors: Xiu
authors: Department of Psychology and Social Behavior, University of California, Irvine, California, 92697, United States of America.
authors: Chuansheng
authors: C
authors: Chen
authors: Department of Biological Chemistry and Institute of Genomics and Bioinformatics, University of California, Irvine, California, 92697, United States of America.
authors: Robert
authors: R
authors: Moyzis
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China.
authors: Mingrui
authors: M
authors: Xia
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China.
authors: Yong
authors: Y
authors: He
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China.
authors: Gui
authors: G
authors: Xue
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China.
authors: Jin
authors: J
authors: Li
authors: Faculty of Psychology, Southwest University, Beibei, Chongqing, 400715, China.
authors: Qinghua
authors: Q
authors: He
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China.
authors: Xuemei
authors: X
authors: Lei
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China.
authors: Yunxin
authors: Y
authors: Wang
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China.
authors: Bin
authors: B
authors: Liu
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China.
authors: Wen
authors: W
authors: Chen
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China.
authors: Bi
authors: B
authors: Zhu
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875,China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China.
authors: Qi
authors: Q
authors: Dong
mesh_terms: D001921:Brain / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D014644:Genetic Variation; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D010551:Personality / Q000235:genetics* / Q000502:physiology; D055815:Young Adult
chemical_list: D004298:Dopamine