title: Different adipose tissue depots: Metabolic implications and effects of surgical removal.
abstract: Increased adiposity has been associated to worse metabolic profile, cardiovascular disease, and mortality. There are two main adipose tissue depots in the body, subcutaneous and visceral adipose tissue, which differ in anatomical location. A large body of evidence has shown the metabolic activity of adipose tissue; lipectomy and/or liposuction therefore appear to be alternatives for improving metabolic profile through rapid loss of adipose tissue. However, surgical removal of adipose tissue may be detrimental for metabolism, because subcutaneous adipose tissue has not been associated to metabolic disorders such as insulin resistance and type 2 diabetes mellitus. In addition, animal studies have shown a compensatory growth of adipose tissue in response to lipectomy. This review summarizes the implications of obesity-induced metabolic dysfunction, its relationship with the different adipose tissue depots, and the effects of lipectomy on cardiometabolic risk factors.
authors: Department of Nutrition, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Health Sciences: Cardiology, Institute of Cardiology of Rio Grande do Sul (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: marcadenti@yahoo.com.br.
authors: Aline
authors: A
authors: Marcadenti
authors: Division of Interventional Cardiology and Postgraduate Program in Cardiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors: Erlon Oliveira
authors: EO
authors: de Abreu-Silva
mesh_terms: D054392:Adipokines / Q000502:physiology; D000273:Adipose Tissue / Q000378:metabolism* / Q000601:surgery; D050154:Adiposity; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D015187:Lipectomy / Q000009:adverse effects / Q000379:methods; D050356:Lipid Metabolism; D015201:Meta-Analysis as Topic; D023421:Models, Animal; D009765:Obesity / Q000378:metabolism* / Q000601:surgery; D009928:Organ Specificity; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D054392:Adipokines
keywords: Adipose tissue; Lipectomy; Lipectomía; Metabolism; Metabolismo; Obesidad; Obesity; Tejido adiposo