title: Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas.
abstract: The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we examined the expression of IKKα in nasopharyngeal carcinoma, which includes non-keratinizing carcinoma and keratinizing squamous cell carcinoma, and lung squamous cell carcinoma with keratinization and non-keratinization. We demonstrated that IKKα expression was almost negative in keratinizing cancer and higher expression of IKKα was found in non-keratinizing cancer, and that IKKα expression correlated with cellular differentiation of tumors in non-keratinizing nasopharyngeal carcinoma. These findings demonstrate that IKKα is diversely expressed in keratinizing and non-keratinizing carcinomas in the same type of cancer.
authors: Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.
authors: Desheng
authors: D
authors: Xiao
authors: Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China.
authors: Jiantao
authors: J
authors: Jia
authors: Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Hunan, 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Hunan, 410078, China.
authors: Ying
authors: Y
authors: Shi
authors: Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.
authors: Chunyan
authors: C
authors: Fu
authors: Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Hunan, 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Hunan, 410078, China.
authors: Ling
authors: L
authors: Chen
authors: Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Hunan, 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Hunan, 410078, China.
authors: Yiqun
authors: Y
authors: Jiang
authors: Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.
authors: Li
authors: L
authors: Zhou
authors: Center for Medicine Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
authors: Shuang
authors: S
authors: Liu
authors: Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Hunan, 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Hunan, 410078, China.
authors: Yongguang
authors: Y
authors: Tao
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D002277:Carcinoma; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D002454:Cell Differentiation; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051550:I-kappa B Kinase / Q000032:analysis* / Q000235:genetics; D053208:Kaplan-Meier Estimate; D007633:Keratins / Q000032:analysis*; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D010641:Phenotype; D011379:Prognosis; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D007633:Keratins; C496559:CHUK protein, human; D051550:I-kappa B Kinase
keywords: IKKα; keratinizing cancer; non-keratinizing cancer