title: Sesterterpenoids with Anticancer Activity.
abstract: Terpenes have received a great deal of attention in the scientific literature due to complex, synthetically challenging structures and diverse biological activities associated with this class of natural products. Based on the number of C5 isoprene units they are generated from, terpenes are classified as hemi- (C5), mono- (C10), sesqui- (C15), di- (C20), sester- (C25), tri (C30), and tetraterpenes (C40). Among these, sesterterpenes and their derivatives known as sesterterpenoids, are ubiquitous secondary metabolites in fungi, marine organisms, and plants. Their structural diversity encompasses carbotricyclic ophiobolanes, polycyclic anthracenones, polycyclic furan-2-ones, polycyclic hydroquinones, among many other carbon skeletons. Furthermore, many of them possess promising biological activities including cytotoxicity and the associated potential as anticancer agents. This review discusses the natural sources that produce sesterterpenoids, provides sesterterpenoid names and their chemical structures, biological properties with the focus on anticancer activities and literature references associated with these metabolites. A critical summary of the potential of various sesterterpenoids as anticancer agents concludes the review.
authors: Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy. evidente@unina.it.
authors: Antonio
authors: A
authors: Evidente
authors: Alexander
authors: A
authors: Kornienko
authors: Florence
authors: F
authors: Lefranc
authors: Alessio
authors: A
authors: Cimmino
authors: Ramesh
authors: R
authors: Dasari
authors: Marco
authors: M
authors: Evidente
authors: Véronique
authors: V
authors: Mathieu
authors: Robert
authors: R
authors: Kiss
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D005658:Fungi / Q000737:chemistry; D006801:Humans; D010944:Plants / Q000737:chemistry; D054830:Sesterterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D054830:Sesterterpenes