title: Enzyme-responsive pillar[5]arene-based polymer-substituted amphiphiles: synthesis, self-assembly in water, and application in controlled drug release.
abstract: An enzyme-responsive drug delivery system was constructed from a pillar[5]arene-based polyethyleneglycol-substituted amphiphile which self-assembles into micelles in water. These micelles exhibit superior drug encapsulation capability, and display drug release behaviour in response to enzyme catalysis, in particular to L-asparaginase. Doxorubicin-loaded micelles show significant cytotoxicity against MCF-7 cancer cells.
authors: Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China. gaolingyan@zju.edu.cn.
authors: Lingyan
authors: L
authors: Gao
authors: Bo
authors: B
authors: Zheng
authors: Wei
authors: W
authors: Chen
authors: Christoph A
authors: CA
authors: Schalley
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D047250:Calixarenes; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D004798:Enzymes / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D011108:Polymers / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D004798:Enzymes; D011108:Polymers; D000644:Quaternary Ammonium Compounds; C570642:pillar(5)arene; D014867:Water; D047250:Calixarenes; D004317:Doxorubicin