title: The interleukin-1β-511 T>C (rs16944) gene polymorphism is associated with risk of developing silent myocardial ischemia in diabetic patients.
abstract: Silent myocardial ischemia (SMI) is a multifactorial and polygenic disorder that results from an excessive inflammatory response. Considering the prominent role of IL-1β, IL-1F10 and IL-1RN as regulators of the inflammatory process and vascular physiology, the aim of the present study was to analyze whether IL-1β, IL-1F10 and IL-1RN single nucleotide polymorphisms (SNPs) are associated with SMI. One polymorphism was associated with risk of SMI. Under co-dominant, recessive and additive models, the IL-1β-511 T>C polymorphism was associated with increased risk of SMI when compared to healthy controls (OR=4.68, 95%CI=2.21-9.92, pCCo-dom=0.0048; OR=3.97, 95%CI=1.97-7.99, pCRec=0.0024; OR=2.02, 95%CI=1.41-2.90, pCAdd=0.0024, respectively). All models were adjusted for gender, age and smoking. Linkage disequilibrium analysis showed four haplotypes (CTCC, CCTC, CCCT and CTCC) with increased frequency in SMI patients when compared to healthy controls (OR=2.53, 95%CI=1.47-4.36, pC=0.0009, OR=2.34, 95%CI=1.15-4.74, pC=0.02, OR=2.44, 95%CI=1.14-5.18, pC=0.02, OR=5.11, 95%CI=1.37-19.05, pC=0.01, respectively). In summary, our data suggest that the IL-1β-511 T>C polymorphism plays an important role in the development of SMI in diabetic patients. In addition, in our study was possible to distinguish one protective and four risk haplotypes for development of SMI.
authors: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors: Gilberto
authors: G
authors: Vargas-Alarcón
authors: Medical Biochemistry Unit of the Specialities Hospital, XXI Century National Medical Center, IMSS, Mexico City, Mexico.
authors: Miguel
authors: M
authors: Cruz-López
authors: Medical Biochemistry Unit of the Specialities Hospital, XXI Century National Medical Center, IMSS, Mexico City, Mexico.
authors: Adán
authors: A
authors: Valladares
authors: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors: Edith
authors: E
authors: Álvarez-León
authors: Epidemiology and Health Service Research Unit, Ageing Area, XXI Century National Medical Center, IMSS, Mexico City, Mexico.
authors: Teresa
authors: T
authors: Juárez-Cedillo
authors: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors: Óscar
authors: Ó
authors: Pérez-Méndez
authors: Clinical Epidemiology Research Unit, Hospital General Regional 1, Dr Carlos McGregor, IMSS, Mexico City, Mexico.
authors: Jorge Escobedo
authors: JE
authors: de-la-Peña
authors: Department of Experimental Medicine, Hospital General de Mexico, Dr. Eduardo Liceaga, Mexico City, Mexico.
authors: Galileo
authors: G
authors: Escobedo
authors: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. Electronic address: mfragoso1275@yahoo.com.mx.
authors: Jose Manuel
authors: JM
authors: Fragoso
mesh_terms: D000368:Aged; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000235:genetics* / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D053583:Interleukin-1beta
keywords: Genetic; Haplotypes; Interleukin 1 antagonist receptor; Interleukin 1B; Polymorphisms; Silent myocardial ischemia