title: Primary intraosseous mucoepidermoid carcinoma of the jaw: Reappraisal of The MD Anderson Cancer Center experience.
abstract: Mucoepidermoid carcinoma arises from major or minor salivary glands, making up 10% of salivary gland tumors. Intraosseous mucoepidermoid carcinomas are rare, and make up only 2% to 3% of all mucoepidermoid carcinomas. The t(11;19) and its CRTC1-MAML2 fusion gene transcript have been identified in mucoepidermoid carcinoma and are associated with a subset of mucoepidermoid carcinomas. The extent to which the transcript influences disease features and patient survival is unclear.
  
  
  
  We conducted a retrospective analysis of records for clinical features, surgical interventions, and prognoses. Reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) used to assess the t(11;19) fusion gene in intraosseous mucoepidermoid carcinoma.
  
  
  
  Twenty-five patients with intraosseous mucoepidermoid carcinoma treated between 1998 and 2013 were identified. The t(11;19) fusion gene transcript CRTC1-MAML2 manifested in 9 intraosseous mucoepidermoid carcinomas, whereas is was not detected in another 9 intraosseous carcinomas. Although the incidence of this fusion in mucoepidermoid carcinoma varies, it is generally accepted that more than 50% of this entity manifest the CRTC1-MAML2.
  
  
  
  Intraosseous mucoepidermoid carcinoma diagnosis should be based on clinical and pathologic manifestations and complete resection is the first choice for patient treatment. The need for neck dissection and adjuvant treatment are debatable. Radiotherapy may improve prognosis and may be recommended in the postoperative period. Primary intraosseous mucoepidermoid carcinoma can manifest the fusion transcript in a subset of tumors. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1312-E1317, 2016.
authors: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.|Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors: Diana
authors: D
authors: Bell
authors: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors: Carol
authors: C
authors: Lewis
authors: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.|Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors: Adel K
authors: AK
authors: El-Naggar
authors: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors: Randal S
authors: RS
authors: Weber
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology* / Q000601:surgery; D002648:Child; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000601:surgery; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics
chemical_list: C500984:CRTC1 protein, human; D004268:DNA-Binding Proteins; C471297:MAML2 protein, human; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D015534:Trans-Activators; D014157:Transcription Factors
keywords: fusion transcript; histogenesis; intraosseous; mucoepidermoid carcinoma; translocation