title: Carboxyhemoglobin Formation in Preterm Infants Is Related to the Subsequent Development of Bronchopulmonary Dysplasia.
abstract: OBJECTIVE
  To evaluate the usefulness of carboxyhemoglobin (CO-Hb) levels as a biomarker to predict the development and severity of bronchopulmonary dysplasia (BPD).
  
  
  METHODS
  Twenty-five infants born at <33 wk of gestational age or with a birth weight of <1,500 g were enrolled. CO-Hb levels were measured between postnatal days 5 and 8, 12 and 15, 19 and 22, and 26 and 29. Urinary levels of 8-hydroxydeoxyguanosine (8-OHdG), advanced oxidation protein products, and Nε-(hexanoyl) lysine were measured between postnatal days 5 and 8 and 26 and 29. Receiver operating characteristic (ROC) analysis was used to compare the biomarkers' predictive values.
  
  
  RESULTS
  Compared with infants in the no-or-mild BPD group, infants with moderate-to-severe BPD exhibited higher CO-Hb levels during the early postnatal period and higher 8-OHdG levels between postnatal days 5 and 8. Using ROC analysis to predict the development of moderate-to-severe BPD, the area under the curve (AUC) for CO-Hb levels between postnatal days 5 and 8 was higher than AUCs for the urinary markers.
  
  
  CONCLUSIONS
  CO-Hb levels during the early postnatal period may serve as a practical marker for evaluating oxidative stress and the severity of subsequently developing BPD.
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-cho, Yoshida-gun, Fukui 9101193, Japan.
authors: Shuko
authors: S
authors: Tokuriki
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-cho, Yoshida-gun, Fukui 9101193, Japan.
authors: Takashi
authors: T
authors: Okuno
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-cho, Yoshida-gun, Fukui 9101193, Japan.
authors: Genrei
authors: G
authors: Ohta
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-cho, Yoshida-gun, Fukui 9101193, Japan.
authors: Yusei
authors: Y
authors: Ohshima
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D062107:Advanced Oxidation Protein Products / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001997:Bronchopulmonary Dysplasia / Q000097:blood* / Q000652:urine; D002263:Carboxyhemoglobin / Q000378:metabolism*; D016022:Case-Control Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood* / Q000652:urine; D008239:Lysine / Q000652:urine; D008297:Male
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers; C120589:N(epsilon)-hexanoyllysine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002263:Carboxyhemoglobin; D003849:Deoxyguanosine; D008239:Lysine