title: Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries.
abstract: The rapid assembly and in situ screening of focused combinatorial fragment libraries using CuAAC click chemistry is a highly robust and efficient strategy for establishing SAR and for discovering bioactive molecules. This review outlines the current status of this methodology in drug discovery application. The inherent limitations, challenges and prospects are critically discussed.
authors: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, China.
authors: Xueshun
authors: X
authors: Wang
authors: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, China.
authors: Boshi
authors: B
authors: Huang
authors: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, China. Electronic address: xinyongllab@163.com.
authors: Xinyong
authors: X
authors: Liu
authors: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, China. Electronic address: zhanpeng1982@sdu.edu.cn.
authors: Peng
authors: P
authors: Zhan
mesh_terms: D057930:Click Chemistry / Q000379:methods*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D055808:Drug Discovery