title: [Vogt-Koyanagi-Harada syndrome (clinical cases)].
abstract: OBJECTIVE
  to analyze two female cases of Vogt-Koyanagi-Harada (VKH) syndrome.
  
  
  METHODS
  The first patient presented with bilateral panuveitis and unilateral keratomalacia (left eye). For the latter, blepharorrhaphy was performed. Methylprednisolone (Metypred) and azathioprine pulses, subsequently switched to oral therapy, caused regression of uveitis. In 1 month the patient was operated for retinal detachment and associated cataract in her right eye. The second patient presented with bilateral detachment of neuroepithelium. Complete reattachment in both eyes was achieved with Metypred pulses followed by oral prednisolone and azathioprine. Bilateral panuveitis with pupil occlusion developed 6 months after the cessation of prednisolone, however, began to resolve as soon as the treatment was resumed.
  
  
  RESULTS
  Timely diagnosis and combination pulse therapy (methylprednisolone and azathioprine) enabled rapid resolution of acute condition.
  
  
  CONCLUSIONS
  Pulse Metypred is the mainstay of the treatment of VKH syndrome. Supplementing the treatment of autoimmune uveitis with low doses of azathioprine slows progression of the disease and minimizes prednisolone-induced side effects. It is important that VKH patients are treated with pathogenetic therapy in close cooperation with an immunologist. Long-term monitoring (not less than 2-3 years) is also necessary.
authors: Khabarovsk branch of the Academician S.N. Fyodorov IRTC 'Eye Microsurgery', 211 Tikhookeanskaya St., Khabarovsk, Russian Federation, 680033; Far Eastern State Medical University, 35 Muravyeva-Amurskogo St., Khabarovsk, Russian Federation, 680000.
authors: E L
authors: EL
authors: Sorokin
authors: Far Eastern State Medical University, 35 Muravyeva-Amurskogo St., Khabarovsk, Russian Federation, 680000.
authors: N V
authors: NV
authors: Voronina
authors: Khabarovsk City Hospital 10, 213 Tikhookeanskaya St., Khabarovsk, Russian Federation, 680033.
authors: S Yu
authors: SY
authors: Avramenko
authors: Khabarovsk branch of the Academician S.N. Fyodorov IRTC 'Eye Microsurgery', 211 Tikhookeanskaya St., Khabarovsk, Russian Federation, 680033.
authors: N V
authors: NV
authors: Pomytkina
mesh_terms: D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D041623:Tomography, Optical Coherence; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone