title: Impact of rituximab maintenance and maintenance schedule on prognosis in first-line treatment of follicular lymphoma. Retrospective analysis from Czech Lymphoma Study Group (CLSG) database.
abstract: Rituximab maintenance (RM) improves time to progression (PFS) in advanced follicular lymphoma (FL), but the impact of various RM schedules remains unknown. This study performed a retrospective evaluation of RM given for up to 2 years vs observation in 319 untreated FL patients (stage II-IV; grade 1-3A) responding to RCHOP induction and a comparison of two different RM schedules (RM8=eight doses given every 3 months and RM12=12 doses given every 2 months). A total of 183 patients received RM and 136 patients were observed; 5-year PFS was better in the RM arm, 74.1% vs 52.3% (p<0.001), which was projected in 5-year OS 93.8% vs 87.5% (p=0.005). However, 5-year PFS was similar in both the RM8 (n=54) and RM12 (n=56) arms. In the first line, RM significantly prolongs PFS and OS in FL, but different RM schedules bring a similar benefit.
authors: a Department of Internal Medicine, Hematology and Oncology , Masaryk University and University Hospital Brno , Brno , Czech Republic .
authors: Andrea
authors: A
authors: Janikova
authors: b Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University , Brno , Czech Republic .
authors: Zbynek
authors: Z
authors: Bortlicek
authors: c Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine , Charles University and Faculty Hospital in Motol , Prague , Czech Republic .
authors: Vit
authors: V
authors: Campr
authors: a Department of Internal Medicine, Hematology and Oncology , Masaryk University and University Hospital Brno , Brno , Czech Republic .
authors: Natasa
authors: N
authors: Kopalova
authors: d 1st Department of Medicine, First Medical Faculty , Charles University and General University Hospital , Prague , Czech Republic .
authors: Katerina
authors: K
authors: Benesova
authors: d 1st Department of Medicine, First Medical Faculty , Charles University and General University Hospital , Prague , Czech Republic .
authors: Jitka
authors: J
authors: Hamouzova
authors: e 4th Department of Internal Medicine, Hematology , Charles University Hospital and Faculty of Medicine , Hradec Králové , Czech Republic .
authors: David
authors: D
authors: Belada
authors: f Department of Hematology , University Hospital Olomouc , Olomouc , Czech Republic .
authors: Vit
authors: V
authors: Prochazka
authors: d 1st Department of Medicine, First Medical Faculty , Charles University and General University Hospital , Prague , Czech Republic .
authors: Robert
authors: R
authors: Pytlik
authors: g Department of Hematooncology , Charles University and University Hospital Pilsen , Pilsen , Czech Republic .
authors: Samuel
authors: S
authors: Vokurka
authors: h Department of Oncology , Hospital Ceske Budejovice , Ceske Budejovice , Czech Republic .
authors: Jan
authors: J
authors: Pirnos
authors: i Department of Clinical Hematology , Teaching Hospital Ostrava , Ostrava , Czech Republic , and.
authors: Juraj
authors: J
authors: Duras
authors: j Internal Clinic of Haematology, University Hospital Kralovske Vinohrady, Prague, Charles University in Prague , 3rd Faculty of Medicine , Prague , Czech Republic.
authors: Heidi
authors: H
authors: Mocikova
authors: a Department of Internal Medicine, Hematology and Oncology , Masaryk University and University Hospital Brno , Brno , Czech Republic .
authors: Jiri
authors: J
authors: Mayer
authors: d 1st Department of Medicine, First Medical Faculty , Charles University and General University Hospital , Prague , Czech Republic .
authors: Marek
authors: M
authors: Trneny
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018153:Czech Republic; D016208:Databases, Factual; D018450:Disease Progression; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000188:drug therapy* / Q000401:mortality* / Q000473:pathology; D060046:Maintenance Chemotherapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D000069283:Rituximab / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000069283:Rituximab
keywords: Follicular lymphoma; maintenance schedule; prognosis; rituximab