title: Polymorphism - 116C/G of the human X box binding protein 1 gene is associated with risk of type 2 diabetes in a Chinese Han population.
abstract: Evidence has been obtained showing that endoplasmic reticulum (ER) stress is closely associated with the development of type 2 diabetes (T2D) and that the human X box binding protein 1 (XBP1) is an important transcription factor involved in the development of ER stress. The study aimed to analyze the potential association between polymorphism -116C/G of XBP1 and the risk of T2D. The association between XBP1 polymorphism -116C/G and T2D risk was assessed among 1058 consecutive unrelated subjects, including 523 T2D patients and 535 healthy controls, in a case control study. The -116GG genotype and -116G allele were more frequent in T2D subjects compared with control subjects by statistical analysis, showing that the -116GG homozygote polymorphism of XBP1 might lead to increased susceptibility to T2D in a Chinese Han population. T2D subjects with the -116GG genotype had higher fasting plasma glucose levels, fasting insulin levels, and HbA1c and worse HOMA-IR than the T2D subjects with -116CG and -116CC genotypes (P<0.0001). The study supports a role for -116C/G polymorphism of the XBP1 promoter in the pathogenesis of T2D in a Chinese Han population, and more studies are needed to further evaluate our results.
authors: Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China; Department of Chronic Disease, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
authors: Shengyuan
authors: S
authors: Liu
authors: Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.
authors: Guoda
authors: G
authors: Ma
authors: Department of Epidemiology and Statistics, College of Public Health, Jiamusi University, Jiamusi 154007, China.
authors: Songpo
authors: S
authors: Yao
authors: Department of Chronic Disease, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
authors: Zhongwei
authors: Z
authors: Chen
authors: Department of Chronic Disease, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.
authors: Changyi
authors: C
authors: Wang
authors: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China. Electronic address: zhaobine@163.net.
authors: Bin
authors: B
authors: Zhao
authors: Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China. Electronic address: likeshen1971@126.com.
authors: Keshen
authors: K
authors: Li
mesh_terms: D000368:Aged; D044466:Asian People; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D000071717:X-Box Binding Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human
keywords: ER stress response; Genotype; Polymorphism; Type 2 diabetes; XBP1