title: Use of statins and the risk of acute pancreatitis: a population-based case-control study.
abstract: OBJECTIVE
  The aim of this research was to examine the association between statin use and the risk of acute pancreatitis.
  
  
  METHODS
  This register-based case-control study with incidence density sampling was based on 4376 patients hospitalized in 2008-2010 for acute pancreatitis and 19 859 randomly selected age and sex-matched controls from the adult population of Finland. The relationship between statin use from 1 January 2004 to the index date and the relative incidence rate of acute pancreatitis was modelled by conditional logistic regression. The rate ratios were adjusted for comorbidities.
  
  
  RESULTS
  A total of 826 (19%) cases and 2589 (13%) controls had been exposed to statins. Statin use was associated with an increased incidence rate of acute pancreatitis (odds ratio (OR) 1.25, 95% confidence interval (CI) 1.13-1.39). This increase was seen especially during the first year of use both among current (OR 1.37, 95% CI 0.94-2.00 for at most 3 months of use and OR 1.32, 95% CI 1.07-1.63 for 4-12 months of use) and former users (OR 1.64, 95% CI 1.33-2.03). The overall association remained when restricting analyses to participants with current use only, or with no history of gallstone or alcohol-related diseases, or with no comorbidities or medicines other than statins.
  
  
  CONCLUSIONS
  Statin use seems to be associated with an increased risk of acute pancreatitis. The association is more apparent during the first year of statin use and among former users.
authors: Finnish Medicines Agency, Kuopio, Finland.
authors: Jaana
authors: J
authors: Kuoppala
authors: Kuopio University Hospital, Kuopio, Finland.
authors: Jukka
authors: J
authors: Pulkkinen
authors: Social Insurance Institution of Finland, Kuopio, Finland.
authors: Helena
authors: H
authors: Kastarinen
authors: Finnish Medicines Agency, Kuopio, Finland.
authors: Vesa
authors: V
authors: Kiviniemi
authors: Finnish Medicines Agency, Kuopio, Finland.
authors: Johanna
authors: J
authors: Jyrkkä
authors: Finnish Medicines Agency, Kuopio, Finland.
authors: Hannes
authors: H
authors: Enlund
authors: Finnish Medicines Agency, Kuopio, Finland.
authors: Pertti
authors: P
authors: Happonen
authors: Kuopio University Hospital, Kuopio, Finland.|University of Eastern Finland, Kuopio, Finland.
authors: Hannu
authors: H
authors: Paajanen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced* / Q000453:epidemiology*; D017891:Pharmacoepidemiology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: acute pancreatitis; density sampling; observational study; pharmacoepidemiology; population-based; register-based; statins