title: Rituximab as an alternative for patients with severe systemic vasculitis refractory to conventional therapy: report of seven cases and literature review.
abstract: The greater understanding of pathophysiology and behavior of systemic vasculitis, together with the development of therapeutic regimens with increasingly better safety and efficacy profiles, dramatically changed the prognosis of patients diagnosed with these clinical entities. Recently, the use of rituximab in the treatment of patients with ANCA-associated vasculitis in randomized clinical trials showed an important alternative in selected cases, especially patients refractory or intolerant to standard therapy with cyclophosphamide and corticosteroids. This article presents the report of seven cases of systemic vasculitis successfully treated with rituximab.
authors: Faculdade de Medicina, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil.
authors: Leonardo Sales
authors: LS
authors: da Silva
authors: Serviço de Reumatologia, Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil.
authors: Karla Valéria Miranda
authors: KV
authors: de Campos
authors: Serviço de Reumatologia, Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil.
authors: Ana Karla Guedes
authors: AK
authors: de Melo
authors: Serviço de Reumatologia, Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil; Curso de Medicina, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil; Departamento de Medicina Interna, Centro de Ciências Médicas, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil.
authors: Danielle Christinne Soares Egypto
authors: DC
authors: de Brito
authors: Serviço de Reumatologia, Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil; Curso de Medicina, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil; Departamento de Medicina Interna, Centro de Ciências Médicas, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil.
authors: Alessandra Sousa
authors: AS
authors: Braz
authors: Serviço de Reumatologia, Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil; Curso de Medicina, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil; Departamento de Medicina Interna, Centro de Ciências Médicas, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil. Electronic address: eutiliafreire@hotmail.com.
authors: Eutilia Andrade Medeiros
authors: EA
authors: Freire
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000188:drug therapy; D058846:Antibodies, Monoclonal, Murine-Derived / Q000009:adverse effects; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D000069283:Rituximab / Q000627:therapeutic use*; D014657:Vasculitis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D058846:Antibodies, Monoclonal, Murine-Derived; D018501:Antirheumatic Agents; D000069283:Rituximab; D003520:Cyclophosphamide
keywords: Granulomatose com poliangeíte; Granulomatosis with polyangiitis; Microscopic polyangiitis; Poliangeíte microscópica; Poliarterite nodosa; Polyarteritis nodosa; Rituximab; Rituximabe; Systemic vasculitides; Vasculites sistêmicas