title: [Electrochemotherapy for treatment of cutaneous metastases].
abstract: Cutaneous metastases occur in up to 9% of all patients with cancer and may cause discomfort and stigmatization. Electrochemotherapy is a local treatment using electric pulses to permeabilize cell membranes, enabling chemotherapy, such as bleomycin, to enter the cells and increase the cytotoxic effect by at least 300-fold. Electrochemotherapy is an efficient, once only treatment for cutaneous metastases with an objective response of 62-99%. Electrochemotherapy can reduce discomfort such as ulceration, oozing, bleeding and pain. Adverse events depend on the size of treatment area, but are very limited.
authors: Onkologisk Afdeling, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev. karen.julie.gehl@regionh.dk.
authors: Hanne
authors: H
authors: Falk
authors: Louise Wichmann
authors: LW
authors: Matthiessen
authors: Karin
authors: K
authors: Dahlstrøm
authors: Julie
authors: J
authors: Gehl
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use; D053672:Electrochemotherapy / Q000009:adverse effects / Q000379:methods; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin