title: Visual Acuity, Contrast Sensitivity and Color Vision Three Years After Iodine-125 Brachytherapy for Choroidal and Ciliary Body Melanoma.
abstract: OBJECTIVE
  To report visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after iodine-125 brachytherapy for choroidal and ciliary body melanoma (CCM).
  
  
  METHODS
  Prospective interventional case series.
  
  
  METHODS
  Thirty-seven patients (37 eyes) with CCM.
  
  
  METHODS
  Patients had best-corrected Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, Pelli-Robson contrast sensitivity and Hardy-Rand-Rittler color vision measurement; comprehensive ophthalmology examination; optical coherence tomography; and ultrasonography at baseline prior to, 1 year after, 2 years after and 3 years after I-125 brachytherapy.
  
  
  METHODS
  Visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after brachytherapy.
  
  
  RESULTS
  Nineteen (19) men and 18 women with mean age of 58 years (SD 13, range 30-78) prior to, 1 year after, 2 years after and 3 years after brachytherapy had mean best-corrected visual acuity of 77 letters (20/32), 65 letters (20/50), 56 letters (20/80) and 47 letters (20/125); contrast sensitivity of 30, 26, 22 and 19 letters; color vision of 26, 20, 17 and 14 test figures, respectively. Decrease in visual acuity, contrast sensitivity and color vision was statistically significant from baseline at 1 year, 2 years, and 3 years after brachytherapy. Decreased acuity at 3 years was associated with mid-choroid and macula melanoma location, ≥ 4.1 mm melanoma height, radiation maculopathy and radiation optic neuropathy.
  
  
  CONCLUSIONS
  1, 2 and 3 years after brachytherapy, eyes with CCM had significantly decreased visual acuity, contrast sensitivity and color vision.
authors: Department of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Irena
authors: I
authors: Tsui
authors: Department of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Robert M
authors: RM
authors: Beardsley
authors: Department of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Tara A
authors: TA
authors: McCannel
authors: Department of Ophthalmology, University of Colorado, Denver, Aurora, CO, USA.
authors: Scott C
authors: SC
authors: Oliver
authors: Department of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Melissa W
authors: MW
authors: Chun
authors: Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Steve P
authors: SP
authors: Lee
authors: Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Phillip E
authors: PE
authors: Chow
authors: Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Nzhde
authors: N
authors: Agazaryan
authors: Department of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Fei
authors: F
authors: Yu
authors: Department of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Bradley R
authors: BR
authors: Straatsma
keywords: Brachytherapy; choroidal melanoma; ciliary body melanoma; contrast sensitivity; visual acuity