title: Does low level laser therapy relieve the pain caused by the placement of the orthodontic separators?--A meta-analysis.
abstract: OBJECTIVE
  Pain caused by orthodontic treatment can affect patient's compliance and even force them to terminate treatments. The aim of this meta-analysis is to evaluate of the analgesic effect of low level laser therapy (LLLT) after placement of the orthodontic separators.
  
  
  METHODS
  Five databases: PubMed, Embase, Cochrane library, China Biology Medicine disc (SinoMed CBM), China National Knowledge Infrastructure (CNKI) were searched for all the appropriate studies in June, 2014. Two reviewers screened the research results under our inclusion criteria and evaluated the risk of bias independently. Then the data of the included studies was extracted for quantitative analysis by the Review Manager 5.1 software.
  
  
  RESULTS
  Six studies were included in our meta-analysis finally. Comparing to the placebo group, the LLLT has good analgesic effect at 6 h, 1d, 2d, 3d after placement of separators which is of statistical significance. While at 2 h, 4d, 5d after the placement, the results tend to support LLLT, but not statistically significant.
  
  
  CONCLUSIONS
  Based on current included studies, LLLT can reduce the pain caused by the placement of separators effectively. However, because of the high heterogeneity, well designed RCTs are required in the future.
authors: Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, 100853, Beijing, China.
authors: Quan
authors: Q
authors: Shi
authors: Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, 100853, Beijing, China.
authors: Shuo
authors: S
authors: Yang
authors: Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, 100853, Beijing, China.
authors: Fangfang
authors: F
authors: Jia
authors: Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, 100853, Beijing, China. newxj@hotmail.com.
authors: Juan
authors: J
authors: Xu
mesh_terms: D000698:Analgesia / Q000379:methods*; D006801:Humans; D028022:Low-Level Light Therapy / Q000379:methods*; D018704:Orthodontic Retainers / Q000009:adverse effects*; D010146:Pain / Q000532:radiotherapy*; D010147:Pain Measurement