title: Propofol-induced rhabdomyolysis: a case report.
abstract: OBJECTIVE
  To report a case of propofol-induced rhabdomyolysis. In this case, widespread myolysis was detected after induction of anesthesia.
  
  
  METHODS
  A 54-year-old female patient was scheduled for a hysterectomy. Beginning shortly after the induction of anesthesia with propofol, several episodes of ventricular fibrillation occurred. Despite intensive care, the patient failed to recover. During most episodes of ventricular fibrillation, marked hyperthermia or hyperkalemia were not observed. Unexplained, widespread myolysis affecting both skeletal and cardiac muscle was observed at autopsy.
  
  
  CONCLUSIONS
  In this patient, the evidence for rhabdomyolysis is robust. Clinical characteristics are similar to those observed in propofol infusion syndrome. The absence of a body temperature over 40 °C precludes the possibility of malignant hyperthermia. Widespread rhabdomyolysis locations cannot be explained by precordial electric shocks. Propofol is the only drug used in this case that has been reported to induce rhabodomyolysis.
  
  
  CONCLUSIONS
  Signs of propofol-induced rhabdomyolysis may be different from those of malignant hyperthermia. Even a regular induction dose of propofol for adults could possibly trigger rhabdomyolysis similar to what is observed in children diagnosed with propofol infusion syndrome. Though rare, care should still be taken when administering propofol.
authors: Zhi-Bin
authors: ZB
authors: Zhou
authors: Xiao-Yu
authors: XY
authors: Yang
authors: Xue
authors: X
authors: Zhou
authors: Li-Jun
authors: LJ
authors: Niu
authors: Liang-Can
authors: LC
authors: Xiao
authors: Wen-Qi
authors: WQ
authors: Huang
authors: Xia
authors: X
authors: Feng
mesh_terms: D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol