title: Comparison of the 2 Most Popular Deconvolution Techniques for the Detection of Penumbral Flow in Acute Stroke.
abstract: OBJECTIVE
  Dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance imaging (MRI) is used to identify the tissue-at-risk in acute stroke, but the choice of optimal DSC postprocessing in the clinical setting remains a matter of debate. Using 15O-water positron emission tomography (PET), we validated the performance of 2 common deconvolution methods for DSC-MRI.
  
  
  METHODS
  In (sub)acute stroke patients with consecutive MRI and PET imaging, DSC maps were calculated applying 2 deconvolution methods, standard and block-circulant single value decomposition. We used 2 standardized analysis methods, a region of interest-based and a voxel-based analysis, where PET cerebral blood flow masks of <20 mL/100 g per minute (penumbral flow) and gray matter masks were overlaid on DSC parameter maps. For both methods, receiver operating characteristic curve analysis was performed to identify the accuracy of each DSC-MR map for the detection of PET penumbral flow.
  
  
  RESULTS
  In 18 data sets (median time after stroke onset: 18 hours; median time PET to MRI: 101 minutes), block-circulant single value decomposition showed significantly better performance to detect PET penumbral flow only for mean transit time maps. Time-to-maximum (Tmax) had the highest performance independent of the deconvolution method.
  
  
  CONCLUSIONS
  Block-circulant single value decomposition seems only significantly beneficial for mean transit time maps in (sub)acute stroke. Tmax is likely the most stable deconvolved parameter for the detection of tissue-at-risk using DSC-MRI.
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.). vince_istvan.madai@charite.de zaroweber@nf.mpg.de.
authors: Olivier
authors: O
authors: Zaro-Weber
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.).
authors: Michelle
authors: M
authors: Livne
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.).
authors: Steve Z
authors: SZ
authors: Martin
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.).
authors: Federico C
authors: FC
authors: von Samson-Himmelstjerna
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.).
authors: Walter
authors: W
authors: Moeller-Hartmann
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.).
authors: Alexander
authors: A
authors: Schuster
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.).
authors: Peter
authors: P
authors: Brunecker
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.).
authors: Wolf-Dieter
authors: WD
authors: Heiss
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.).
authors: Jan
authors: J
authors: Sobesky
authors: From the Max-Planck-Institute for Metabolism Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.); Center for Stroke Research Berlin (CSB) (M.L., S.Z.M., F.C.v.S.-H., P.B., J.S., V.I.M.) and Department of Neurology (J.S., V.I.M.), Charité-Universitätsmedizin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany (F.C.v.S.-H.); Department of Radiology, Ludmillenstift, Meppen, Germany (W.M.-H.); and Max-Planck-Institute for Neurological Research, Cologne, Germany (O.Z.-W., A.S., W.-D.H.). vince_istvan.madai@charite.de zaroweber@nf.mpg.de.
authors: Vince I
authors: VI
authors: Madai
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001921:Brain / Q000098:blood supply* / Q000473:pathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012372:ROC Curve; D012189:Retrospective Studies; D020521:Stroke / Q000473:pathology*
keywords: magnetic resonance imaging; perfusion imaging; positron-emission tomography; stroke