title: Neural stem cell therapy for cancer.
abstract: Cancers of the brain remain one of the greatest medical challenges. Traditional surgery and chemo-radiation therapy are unable to eradicate diffuse cancer cells and tumor recurrence is nearly inevitable. In contrast to traditional regenerative medicine applications, engineered neural stem cells (NSCs) are emerging as a promising new therapeutic strategy for cancer therapy. The tumor-homing properties allow NSCs to access both primary and invasive tumor foci, creating a novel delivery platform. NSCs engineered with a wide array of cytotoxic agents have been found to significantly reduce tumor volumes and markedly extend survival in preclinical models. With the recent launch of new clinical trials, the potential to successfully manage cancer in human patients with cytotoxic NSC therapy is moving closer to becoming a reality.
authors: Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors: Juli Rodriguez
authors: JR
authors: Bagó
authors: Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors: Kevin T
authors: KT
authors: Sheets
authors: Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Biomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: hingtgen@email.unc.edu.
authors: Shawn D
authors: SD
authors: Hingtgen
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D060846:Cell Engineering; D002465:Cell Movement; D065150:Cellular Reprogramming; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D058953:Neural Stem Cells / Q000502:physiology / Q000637:transplantation*
keywords: Cancer therapy; Drug delivery; Gene therapy; Glioblastoma; Neural stem cell