title: [Exosomes Derived from Mesenchymal Stem Cells--the Future Ideal Vector of Biological Therapy].
abstract: MSC-exosomes are homogeneous menbrane vesicles with diameter 40-100 nm, derived from mesenchymal stem cells at physiological or pathology conditions. MSC-exosomes contain a great quantity and a wide variety of bioactive substances, such as proteins and miRNA. MSC-exosomes transfer bioactive substances to recipient cells to affect their functions through membrane fusion or endocytosis, which like the storage pools of signal vehicles for cell-to-cell comunication in vivo. MSC-exosomes can mimic the beneficial effect of MSC treatment, such as the promotion of tissue repair or the immune regulation. The biological property and functions of MSC-exosomes are reviwed in this article.
authors: Jiangxi Provincial Key Laboratory of Hemotologic Diseases, Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors: Juan
authors: J
authors: Zhang
authors: Jiangxi Provincial Key Laboratory of Hemotologic Diseases, Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors: Jing-Shu
authors: JS
authors: Shi
authors: Jiangxi Provincial Key Laboratory of Hemotologic Diseases, Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. E-mail: thj127900@163.com.
authors: Jian
authors: J
authors: Li
mesh_terms: D001691:Biological Therapy; D002450:Cell Communication; D055354:Exosomes; D006801:Humans; D059630:Mesenchymal Stem Cells; D035683:MicroRNAs
chemical_list: D035683:MicroRNAs