title: Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991.
abstract: Three new phthalide derivatives, emefuranones A1, A2 and B (1-3); six new phthalane derivatives, emefuran A, B1, B2, C1, C2 and D (4-9); three new farnesylated phthalide derivatives, farnesylemefuranones A-C (10-12); xylarinol C (13); and emericelloxide (14), along with four known compounds (dustanin, sorbicillin, aspergillodiol and xylarinol A), were isolated from the culture extracts of Emericella sp. IFM57991. Structures of 1-14 were elucidated on the basis of spectroscopic analysis and chemical evidence. Compounds 4-7 and 13 showed moderate antibacterial activities against Bacillus subtilis.
authors: Department of Organic Chemistry, Hoshi University, Tokyo, Japan.
authors: Tetsuya
authors: T
authors: Saito
authors: Department of Organic Chemistry, Hoshi University, Tokyo, Japan.
authors: Takeshi
authors: T
authors: Itabashi
authors: Department of Organic Chemistry, Hoshi University, Tokyo, Japan.
authors: Daigo
authors: D
authors: Wakana
authors: Department of Organic Chemistry, Hoshi University, Tokyo, Japan.
authors: Hisashi
authors: H
authors: Takeda
authors: Medical Mycology Research Center (MMRC), Chiba University, Chiba, Japan.
authors: Takashi
authors: T
authors: Yaguchi
authors: Department of Organic Chemistry, Hoshi University, Tokyo, Japan.
authors: Ken-ichi
authors: K
authors: Kawai
authors: Department of Organic Chemistry, Hoshi University, Tokyo, Japan.
authors: Tomoo
authors: T
authors: Hosoe
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003470:Culture Media / Q000737:chemistry*; D052978:Disk Diffusion Antimicrobial Tests; D032842:Emericella / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010797:Phthalimides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D001572:Benzofurans; D003470:Culture Media; D010797:Phthalimides; C082022:phthalide; C005020:folpet