title: Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.
abstract: BACKGROUND
  Chronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory and oxidative stress. We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femoral pulse wave velocity (c-f PWV).
  
  
  METHODS
  The study group included 303 subjects, mean age 51.8 ±13.3 years, free of known cardiovascular diseases and regular drug consumption. For each patient, blood pressure was measured, blood samples were available for biochemical parameters, and LTL was analyzed by real time q PCR. C-f PWV was measured with the help of SphygmoCor. SAS 9.1 was used for statistical analysis.
  
  
  RESULTS
  Through multiple linear regression analysis, c-f PWV is independently and positively associated with age (p = 0.0001) and the homeostasis model assessment of insulin resistance (HOMA-IR; p = 0.0001) and independently negatively associated with LTL (p = 0.0378). HOMA-IR seems to have a stronger influence than SBP on arterial stiffness. In all subjects, age, HOMA-IR, LTL, and SBP predicted 32% of the variance in c-f PWV. LTL was inversely associated with HOMA-IR (p = 0.0001) and age (p = 0.0001). In all subjects, HOMA-IR, age, sex, and SBP predicted 16% of the variance in LTL.
  
  
  CONCLUSIONS
  These data suggest that IR is associated with cell senescence and arterial aging and could, therefore, become the main target in preventing accelerated arterial aging, besides blood pressure control. Research in telomere biology may reveal new ways of estimating cardiovascular aging and risk.
authors: Department of aging and age-associated diseases prevention, National Research Center for Preventive Medicine, Moscow, Russian Federation.
authors: Irina
authors: I
authors: Strazhesko
authors: Department of aging and age-associated diseases prevention, National Research Center for Preventive Medicine, Moscow, Russian Federation.
authors: Olga
authors: O
authors: Tkacheva
authors: Department of Clinical Cardiology and Molecular Genetics, National Research Center for Preventive Medicine, Moscow, Russian Federation.
authors: Sergey
authors: S
authors: Boytsov
authors: Department of aging and age-associated diseases prevention, National Research Center for Preventive Medicine, Moscow, Russian Federation.
authors: Dariga
authors: D
authors: Akasheva
authors: Department of aging and age-associated diseases prevention, National Research Center for Preventive Medicine, Moscow, Russian Federation.
authors: Ekaterina
authors: E
authors: Dudinskaya
authors: Department of Epidemiology of Chronic Non-Communicable Diseases Laboratory of Biostatistics, National Research Center for Preventive Medicine, Moscow, Russian Federation.
authors: Vladimir
authors: V
authors: Vygodin
authors: Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation.
authors: Dmitry
authors: D
authors: Skvortsov
authors: Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden.
authors: Peter
authors: P
authors: Nilsson
mesh_terms: D000328:Adult; D000375:Aging; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002339:Carotid Arteries / Q000503:physiopathology; D016922:Cellular Senescence; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D059505:Telomere Homeostasis; D059289:Vascular Stiffness