title: Experimental treatments of endometriosis.
abstract: Endometriosis is defined as the presence of endometrial gland and stroma outside the uterine cavity. It is an estrogen-dependent disease and is associated with chronic pelvic pain, dysmenorrhea, dyspareunia and infertility. The treatment of endometriosis is conservative or radical surgery, medical therapies or their combination. All currently used hormonally active treatments are effective in the treatment of endometriosis; however, the adverse effects of these hormonal treatments limit their long-term use. Moreover, recurrence rates are high after cessation of therapy, and the treatments have no benefit in endometriosis-associated infertility. Therefore, researchers are working on new treatment modalities with improved side effects, mainly focusing on the molecular targets involved in etiopathogenesis of endometriosis. Here we summarized these novel treatments modalities.
authors: Yeditepe University Medical School, İnönü Mah., Kayışdağı Cad., 26 Ağustos Yerleşimi, 34755 Ataşehir/İstanbul, Turkey.
authors: Rukset
authors: R
authors: Attar
authors: Istanbul University Istanbul Medical School, Topkapı Mh., Millet Caddesi, Çapa, 34093 Fatih/İstanbul, Turkey.
authors: Erkut
authors: E
authors: Attar
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D015507:Drugs, Investigational / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000601:surgery; D004717:Endometrium / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control*; D017699:Pelvic Pain / Q000517:prevention & control; D035703:Therapies, Investigational / Q000379:methods*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015507:Drugs, Investigational
keywords: antiangiogenic agents; antioxidant agents; apoptotic agent; aromatase; aromatase inhibitors; dopamine; endometriosis; treatment