title: [Research Progress on TKI Resistance of CML Cells Mediated by MSC through CXCL12/CXCR4 Axis].
abstract: Although the tyrosinekinase inhibitors (TKI) displayed a significant curative effect on chronic myeloid leukemia (CML), but the drug resistance in treatment course of this disease still can not be avoided. Studies recently have shown that the mesenchymal stem cells (MSC) can induce CML cells to resist TKI therapy by CXCL12/CXCR4 axis from multiple aspects, such as the directional migration of CML cells, adherence to marrow cavity, the mediation of cell protective dormancy, activations of numerous survival signaling pathways, the suppression of mitochondrial-dependent apoptosis and the up-regulated expression of BCL-6. The combination of TKI and CXCR4 antagonists will be a novel treatment strategy to raise the genetic cure rate of CML. In this article, the pathways of drug resistance, pathways of sensitivity to CXCL12 and pathways of CML cell adherence to marrow cavity in CML cells mediated by MSC were reviewed.
authors: Key Laboratory of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.|Medical Department of Nanchang University Graduate School, Nanchang 330006, Jiangxi Province, China.
authors: Li-Jun
authors: LJ
authors: Fang
authors: Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors: Huai-Jun
authors: HJ
authors: Tu
authors: Key Laboratory of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. E-mail: jeniferjian@gmail.com.
authors: Jian
authors: J
authors: Li
mesh_terms: D019008:Drug Resistance, Neoplasm; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases; D015398:Signal Transduction; D013234:Stem Cells
chemical_list: D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases