title: Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy.
abstract: Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies. To further investigate the pathophysiology of MMN and PMA we determined concentrations of 16 mainly B-cell associated inflammatory markers in serum from 25 patients with MMN, 55 patients with PMA, 25 patients with amyotrophic lateral sclerosis (ALS) and 50 healthy controls. Median serum concentrations of the 16 tested cytokines and chemokines were not significantly increased in patients with MMN or patients with PMA, irrespective of the presence of IgM monoclonal gammopathy or high IgM anti-GM1 antibodies. These results argue against a systemic B-cell mediated immune response underlying the pathogenesis of MMN and PMA.
authors: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: L
authors: L
authors: Vlam
authors: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: M
authors: M
authors: Stam
authors: Department of Pediatric Immunology, Multiplex Core Facility, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: W
authors: W
authors: de Jager
authors: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: E A
authors: EA
authors: Cats
authors: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: L H
authors: LH
authors: van den Berg
authors: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: W.L.vanderPol@umcutrecht.nl.
authors: W L
authors: WL
authors: van der Pol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D001323:Autoantibodies; D053264:B-Cell Activating Factor / Q000378:metabolism; D016009:Chi-Square Distribution; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009134:Muscular Atrophy, Spinal / Q000097:blood*; D011115:Polyneuropathies / Q000097:blood*; D018709:Statistics, Nonparametric
chemical_list: D001323:Autoantibodies; D053264:B-Cell Activating Factor; D016207:Cytokines; D007075:Immunoglobulin M; D005677:G(M1) Ganglioside
keywords: B-cell; Cytokine; Motor neuron disease; Multifocal motor neuropathy