title: Mouse Models of Hepatitis B Virus Pathogenesis.
abstract: The host range of hepatitis B virus (HBV) is limited to humans and chimpanzees. As discussed in the literature, numerous studies in humans and chimpanzees have generated a great deal of information on the mechanisms that cause viral clearance, viral persistence, and disease pathogenesis during acute or chronic HBV infection. Relevant pathogenetic studies have also been performed in those few species representing natural hosts of hepadnaviruses that are related to HBV, such as the woodchuck hepatitis virus and the duck hepatitis virus. Further insight has been gained from multidisciplinary studies in transgenic or humanized chimeric mouse models expressing and/or replicating HBV to varying degrees. We provide here a concise summary of the available HBV mouse models as well as of the contributions of these models to our understanding of HBV pathogenesis.
authors: Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy Vita-Salute San Raffaele University, 20132 Milan, Italy.
authors: Matteo
authors: M
authors: Iannacone
authors: Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy Department of Immunology & Microbial Sciences, The Scripps Research Institute, La Jolla, California 92037.
authors: Luca G
authors: LG
authors: Guidotti
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006509:Hepatitis B / Q000821:virology*; D006515:Hepatitis B virus / Q000472:pathogenicity / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000821:virology; D051379:Mice