title: An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation.
abstract: Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C-C bond forming step.
authors: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield road, OX1 3TA, UK. stephen.fletcher@chem.ox.ac.uk.
authors: Diego
authors: D
authors: Caprioglio
authors: Stephen P
authors: SP
authors: Fletcher
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D002384:Catalysis; D004958:Estradiol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000077267:Fulvestrant
chemical_list: D000970:Antineoplastic Agents; D000077267:Fulvestrant; D004958:Estradiol