title: MMP-2 -1575G/A polymorphism modifies the onset of optic neuritis as a first presenting symptom in MS?
abstract: Previous studies show altered activities of matrix metalloproteinase (MMP)-2 and MMP-9 in serum and cerebrospinal fluid of multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. Optic neuritis (ON) is a common symptom of both disorders. Here we investigated the impacts of MMP-2 -1575G/A and MMP-9 -1562 C/T gene polymorphisms on disease phenotype in 100 MS patients with ON as a first symptom and 376 MS patients with other initial symptomatology. The MMP-2 -1575G/A polymorphism led to a 5-year-earlier age of disease onset in MS patients with ON as a first symptom (p=0.009).
authors: Department of Neurology, Clinical Hospital Center Rijeka, Rijeka, Croatia.
authors: Iva
authors: I
authors: Gašparović
authors: Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Rijeka, Croatia.
authors: Nada Starčević
authors: NS
authors: Čizmarević
authors: Clinical Institute of Medical Genetics, University Medical Centre, Ljubljana, Slovenia.
authors: Luca
authors: L
authors: Lovrečić
authors: Department of Neurology, Clinical Hospital Center Rijeka, Rijeka, Croatia.
authors: Olivio
authors: O
authors: Perković
authors: Clinical Institute of Medical Genetics, University Medical Centre, Ljubljana, Slovenia.
authors: Polona
authors: P
authors: Lavtar
authors: Postgraduate Studies, School of Medicine, University of Rijeka, Rijeka, Croatia.
authors: Juraj
authors: J
authors: Sepčić
authors: Department of Neurology, University Medical Centre, Ljubljana, Slovenia.
authors: Saša Šega
authors: SŠ
authors: Jazbec
authors: Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Rijeka, Croatia.
authors: Miljenko
authors: M
authors: Kapović
authors: Clinical Institute of Medical Genetics, University Medical Centre, Ljubljana, Slovenia.
authors: Borut
authors: B
authors: Peterlin
authors: Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Rijeka, Croatia. Electronic address: smiljana.ristic@medri.uniri.hr.
authors: Smiljana
authors: S
authors: Ristić
mesh_terms: D000328:Adult; D017668:Age of Onset; D000704:Analysis of Variance; D000818:Animals; D004185:Disability Evaluation; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D009103:Multiple Sclerosis / Q000150:complications* / Q000235:genetics*; D009902:Optic Neuritis / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017207:Rats, Sprague-Dawley; D055815:Young Adult
chemical_list: D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
keywords: Age of disease onset; MMP-2; MMP-9; Multiple sclerosis; Optic neuritis; Susceptibility