title: Neurodegeneration: A Leg Up on TDP-43.
abstract: TDP-43 is a key disease protein for amyotrophic lateral sclerosis but how it drives motor neuron degeneration remains unresolved. A new study has modeled TDP-43 age-dependent axonal death in the Drosophila leg and used a powerful forward genetic screen to identify three novel suppressor genes.
authors: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: figley@stanford.edu.
authors: Matthew D
authors: MD
authors: Figley
authors: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.
authors: Aaron D
authors: AD
authors: Gitler
mesh_terms: D000375:Aging; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000502:physiology*; D006801:Humans; D009046:Motor Neurons / Q000502:physiology*; D009410:Nerve Degeneration / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins