title: Systems medicine of inflammaging.
abstract: Systems Medicine (SM) can be defined as an extension of Systems Biology (SB) to Clinical-Epidemiological disciplines through a shifting paradigm, starting from a cellular, toward a patient centered framework. According to this vision, the three pillars of SM are Biomedical hypotheses, experimental data, mainly achieved by Omics technologies and tailored computational, statistical and modeling tools. The three SM pillars are highly interconnected, and their balancing is crucial. Despite the great technological progresses producing huge amount of data (Big Data) and impressive computational facilities, the Bio-Medical hypotheses are still of primary importance. A paradigmatic example of unifying Bio-Medical theory is the concept of Inflammaging. This complex phenotype is involved in a large number of pathologies and patho-physiological processes such as aging, age-related diseases and cancer, all sharing a common inflammatory pathogenesis. This Biomedical hypothesis can be mapped into an ecological perspective capable to describe by quantitative and predictive models some experimentally observed features, such as microenvironment, niche partitioning and phenotype propagation. In this article we show how this idea can be supported by computational methods useful to successfully integrate, analyze and model large data sets, combining cross-sectional and longitudinal information on clinical, environmental and omics data of healthy subjects and patients to provide new multidimensional biomarkers capable of distinguishing between different pathological conditions, e.g. healthy versus unhealthy state, physiological versus pathological aging.
authors: Gastone C
authors: GC
authors: Castellani
authors: Giulia
authors: G
authors: Menichetti
authors: Paolo
authors: P
authors: Garagnani
authors: Maria
authors: M
authors: Giulia Bacalini
authors: Chiara
authors: C
authors: Pirazzini
authors: Claudio
authors: C
authors: Franceschi
authors: Sebastiano
authors: S
authors: Collino
authors: Claudia
authors: C
authors: Sala
authors: Daniel
authors: D
authors: Remondini
authors: Enrico
authors: E
authors: Giampieri
authors: Ettore
authors: E
authors: Mosca
authors: Matteo
authors: M
authors: Bersanelli
authors: Silvia
authors: S
authors: Vitali
authors: Italo Faria do
authors: IF
authors: Valle
authors: Pietro
authors: P
authors: Liò
authors: Luciano
authors: L
authors: Milanesi
mesh_terms: D015415:Biomarkers; D003430:Cross-Sectional Studies; D006801:Humans; D007249:Inflammation; D009369:Neoplasms; D013597:Systems Analysis; D049490:Systems Biology
chemical_list: D015415:Biomarkers
keywords: ecological model; inflammation; multi-scale; multilayer networks; networks; propagation