title: Serious stomatitis and esophagitis: a peculiar mucous reaction induced by pegylated liposomal doxorubicin.
abstract: Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palmar-plantar erythrodysesthesia, diffuse follicular rash, intertrigo-like eruption, new formation of melanotic macules, stomatitis and radiation recall dermatitis. We present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin.
authors: Sun Yat-sen University, Guangzhou, CN.
authors: Han
authors: H
authors: Ma
authors: Sun Yat-sen University, Guangzhou, CN.
authors: Meilan
authors: M
authors: Chen
authors: Sun Yat-sen University, Guangzhou, CN.
authors: Junru
authors: J
authors: Liu
authors: Sun Yat-sen University, Guangzhou, CN.
authors: Ying
authors: Y
authors: Li
authors: Sun Yat-sen University, Guangzhou, CN.
authors: Juan
authors: J
authors: Li
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D004317:Doxorubicin / Q000009:adverse effects / Q000031:analogs & derivatives*; D004941:Esophagitis / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D060831:Hand-Foot Syndrome / Q000209:etiology* / Q000473:pathology; D006801:Humans; D009061:Mouth Mucosa / Q000187:drug effects; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy; D011092:Polyethylene Glycols / Q000009:adverse effects; D013280:Stomatitis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; C506643:liposomal doxorubicin; D011092:Polyethylene Glycols; D004317:Doxorubicin