title: Abdominal Respiration Induces Hemodilution and Related Reduction in ADH Concentration of Blood.
abstract: To establish effective lymph drainage methods and develop concise and accurate clinical techniques for evaluating lymph drainage in healthy individuals and patients with cancer treatment-related lymph edema, we investigated the numbers of red (RBC) and white (WBC) blood cells, and platelets (PLT) in blood, hematocrit (Ht), and the blood concentrations of total protein (TP), albumin (Alb), and anti-diuretic hormone (ADH) before and after 5 min manual lymph drainage, followed by 30 min rest with or without abdominal respiration in the supine or sitting position in 48 healthy volunteers. The 5 min facial, upper and lower extremities lymph drainage, followed by 30 min rest in the supine position induced significant reductions of the TP and Alb in all subjects, and their RBC and Ht levels in some subjects. The 30 min rest only in the supine position without lymph drainage produced also significant reductions of blood TP and Alb. In addition, abdominal respiration in the supine position without manual lymph drainage caused more significant hemodilution, being significant reductions of TP, Alb, RBC, Ht, and ADH in all volunteers. These findings may be related to effective lymph drainage from the chylocyst. Furthermore, it also resulted in a significantly increased micturition desire. In conclusion, abdominal respiration during 30 min rest in the supine position is effective at inducing lymph drainage, and the associated induction of hemodilution and lowering of the blood ADH concentration (and increased micturition desire in some cases) can be used to accurately assess the extent of lymph drainage.
authors: 1 Department of Innovation of Medical and Health Sciences Research, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .|2 Department of Physiology, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .
authors: Yoshiko
authors: Y
authors: Kawai
authors: 2 Department of Physiology, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .
authors: Kumiko
authors: K
authors: Ajima
authors: 2 Department of Physiology, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .
authors: Takashi
authors: T
authors: Nagai
authors: 1 Department of Innovation of Medical and Health Sciences Research, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .|2 Department of Physiology, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .
authors: Yumiko
authors: Y
authors: Yokoyama
authors: 1 Department of Innovation of Medical and Health Sciences Research, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .|2 Department of Physiology, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .
authors: Maki
authors: M
authors: Kaidoh
authors: 3 Department of Nursing, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .
authors: Emi
authors: E
authors: Seto
authors: 4 Department of Laboratory Medicine, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .
authors: Takayuki
authors: T
authors: Honda
authors: 1 Department of Innovation of Medical and Health Sciences Research, Shinshu University School of Medicine, and Shinshu University Hospital , Matsumoto, Japan .
authors: Toshio
authors: T
authors: Ohhashi
mesh_terms: D000328:Adult; D015415:Biomarkers; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008196:Lymph; D008208:Lymphatic System / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009481:Neurophysins / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D012119:Respiration; D013997:Time Factors; D014667:Vasopressins / Q000097:blood*
chemical_list: C438657:AVP protein, human; D015415:Biomarkers; D009481:Neurophysins; D011498:Protein Precursors; D014667:Vasopressins