title: IL-17 polymorphisms and asthma risk: a meta-analysis of 11 single nucleotide polymorphisms.
abstract: OBJECTIVE
  There has been significant interest in the association between asthma and the polymorphisms of IL-17A and IL-17F for a period of time. This work aims to present a clearer relationship between asthma and the polymorphisms of IL-17A and IL-17F.
  
  
  METHODS
  Searches were performed in Medline, EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the relationship between polymorphisms of IL-17A and IL-17F and asthma.
  
  
  RESULTS
  Nine studies comprising 3650 asthmatics and 3370 controls were included in this meta-analysis for all single nucleotide polymorphisms (SNPs) (2-6 per SNP). Our study examined the polymorphisms of IL-17F rs1889570 (C/T) (CC versus TT: OR = 0.55, 95%CI = 0.41-0.75; CT versus TT: OR = 0.54, 95%CI = 0.40-0.72; CC/CT versus TT: OR = 0.55, 95%CI = 0.42-0.72; CC versus CT/TT, OR = 1.83, 95%CI = 1.39-2.41), IL-17A rs4711998(A/G) (AA/AG versus GG: OR = 0.67, 95%CI = 0.46-0.98), and IL-17A rs3819024(A/G) (AA versus GG: OR = 1.77, 95%CI = 1.39-2.25) and found they were significantly related to the risk of asthma.
  
  
  CONCLUSIONS
  Our systematic review showed that IL-17F rs1889570(C/T), IL-17A rs4711998(A/G) and IL-17A rs3819024(A/G) may be potential risk factors for asthma susceptibility.
authors: a Department of Respiratory Disease , Taizhou Municipal Hospital , Taizhou , China and.
authors: Yan
authors: Y
authors: Jin
authors: b Department of Respiratory Medicine , Affiliated Hospital of School of Medicine, Ningbo University , Ningbo , China.
authors: Zaichun
authors: Z
authors: Deng
authors: b Department of Respiratory Medicine , Affiliated Hospital of School of Medicine, Ningbo University , Ningbo , China.
authors: Chao
authors: C
authors: Cao
authors: a Department of Respiratory Disease , Taizhou Municipal Hospital , Taizhou , China and.
authors: Longxiang
authors: L
authors: Li
mesh_terms: D044466:Asian People; D001249:Asthma / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17
keywords: Asthma; IL-17A; IL-17F; meta-analysis; polymorphism