title: The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model.
abstract: The neurotoxin 6-hydroxydopamine (6-OHDA) is widely used to induce models of Parkinson's disease (PD). We now know that the model induced by 6-OHDA does not include all PD symptoms, although it does reproduce the main cellular processes involved in PD, such as oxidative stress, neurodegeneration, neuroinflammation, and neuronal death by apoptosis. In this review we analyse the factors affecting the vulnerability of dopaminergic neurons as well as the close relationships between neuroinflammation, neurodegeneration, and apoptosis in the 6-OHDA model. Knowledge of the mechanisms involved in neurodegeneration and cell death in this model is the key to identifying potential therapeutic targets for PD.
authors: Cátedra CONACyT, Dirección Adjunta de Desarrollo Científico CONACyT, México, D. F., México; Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, México. Electronic address: dan.hernandez.baltazar@gmail.com.
authors: D
authors: D
authors: Hernandez-Baltazar
authors: Centro de Investigación Biomédica del Noreste, IMSS, Monterrey, Nuevo León, México.
authors: L M
authors: LM
authors: Zavala-Flores
authors: Departamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors: A
authors: A
authors: Villanueva-Olivo
mesh_terms: D018663:Adrenergic Agents / Q000009:adverse effects*; D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D059290:Dopaminergic Neurons / Q000187:drug effects; D006801:Humans; D009420:Nervous System / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D016627:Oxidopamine / Q000009:adverse effects*; D010300:Parkinson Disease / Q000503:physiopathology*; D013378:Substantia Nigra / Q000187:drug effects
chemical_list: D018663:Adrenergic Agents; D016627:Oxidopamine
keywords: Apoptosis; Estrés oxidativo; Neurodegeneración; Neurodegeneration; Neuroinflamación; Neuroinflammation; Nigrostriatal pathway; Oxidative stress; Substantia nigra; Vía nigroestriatal