title: Terpenoids from the Octocoral Sinularia gaweli.
abstract: Two eudesmane sesquiterpenoids, verticillatol (1) and 5α-acetoxy-4(14)-eudesmene-1β-ol (2) and two cembrane diterpenoids, (-)-leptodiol acetate (3) and sinulacembranolide A (4) were isolated from the octocoral Sinularia gaweli and compounds 2-4 are new isolates. The structures of new terpenoids 2-4 were elucidated by spectroscopic methods and by comparison the spectral data with those of known analogues. Terpenoid 4 was found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 marcophage cells.
authors: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. abcdewq213@hotmail.com.|National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan. abcdewq213@hotmail.com.
authors: Wun-Jie
authors: WJ
authors: Lin
authors: Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. kuma0401@gmail.com.
authors: Tung-Ying
authors: TY
authors: Wu
authors: Department of Beauty Science, Meiho University, Pingtung 912, Taiwan. a081002@mail.tsmh.org.tw.|Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan. a081002@mail.tsmh.org.tw.
authors: Tzu-Rong
authors: TR
authors: Su
authors: Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
authors: Zhi-Hong
authors: ZH
authors: Wen
authors: Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@mail.tajen.edu.tw.
authors: Jih-Jung
authors: JJ
authors: Chen
authors: Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
authors: Lee-Shing
authors: LS
authors: Fang
authors: Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
authors: Yang-Chang
authors: YC
authors: Wu
authors: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.|Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.
authors: Ping-Jyun
authors: PJ
authors: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000276:immunology; D012717:Sesquiterpenes / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C454499:verticillatol; D052247:Nitric Oxide Synthase Type II
keywords: Sinularia gaweli; cembrane; eudesmane; iNOS; octocoral