title: Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties.
abstract: Compact polymerized polydiacetylene-micelles with "stealth" zwitterionic surface coating were assembled and tested in a murine xenograft model of breast cancer. In vivo fluorescence imaging indicated accumulation in the tumor area and histological studies revealed predominant uptake of the micelles at the margins of the tumor, thereby allowing the delineation of its volume.
authors: CEA, I2BM, Molecular Imaging Research Center (MIRCen), 18 route du panorama, BP no 6, 92265 Fontenay-aux-Roses, France.
authors: Ioanna
authors: I
authors: Theodorou
authors: Parambath
authors: P
authors: Anilkumar
authors: Benoit
authors: B
authors: Lelandais
authors: Damien
authors: D
authors: Clarisse
authors: Anaëlle
authors: A
authors: Doerflinger
authors: Edmond
authors: E
authors: Gravel
authors: Frédéric
authors: F
authors: Ducongé
authors: Eric
authors: E
authors: Doris
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D064593:Heterografts; D051379:Mice; D008823:Micelles; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D053279:Polyynes / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D008823:Micelles; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene