title: A Phosphoinositide Code for Primary Cilia.
abstract: How phosphoinositide metabolism is coupled to primary cilia physiology is poorly understood. Reporting recently in Developmental Cell, Chávez et al. (2015) and Garcia-Gonzalo et al. (2015) show that INPP5E-mediated phosphoinositide metabolism, which creates a specific phosphoinositide distribution, ensures proper protein trafficking and Hh signaling in primary cilia.
authors: Department of Neurochemistry and Molecular Cell Biology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. Electronic address: nakatsu@med.niigata-u.ac.jp.
authors: Fubito
authors: F
authors: Nakatsu
mesh_terms: D000818:Animals; D002923:Cilia / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D011506:Proteins / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D053823:Hedgehog Proteins; D018129:Phosphatidylinositol Phosphates; D011506:Proteins; D043562:Receptors, G-Protein-Coupled; D010744:Phosphoric Monoester Hydrolases