title: Age-related decrease in CD271(+) cells in human skin.
abstract: According to recent studies, stem cells are found in various tissues in our bodies. It has been reported that stem cells can reside in the skin tissues, including the epidermis, dermis, hair follicles and subcutaneous tissues. Homeostasis of the skin is maintained because these stem cells collaborate with each other to form new cells. We previously identified the CD271(p75NTR)(+) cell as a stem cell that was present in the epidermis, dermis and subcutaneous tissue, and further investigated the role of stem cells in wound healing and their association with skin disease. In this study, we investigated the localization of CD271(+) cells in human skin (epidermis and dermis) and its age-related changes in stem cells using CD271(+) cells. The study revealed that the number of CD271(+) cells in the epidermis and dermis decreased with aging. It is possible that such an age-related decrease in stem cells causes impaired regenerative ability and is associated with various skin diseases. If the relationship between stem cells and skin aging and diseases can be elucidated by investigations such as this study, it may lead to the development of novel anti-aging technologies and medical treatments for skin diseases in the future.
authors: Department of Applied Cell and Regenerative Medicine, Fujita Health University School of Medicine, Aichi, Japan.
authors: Hirohiko
authors: H
authors: Akamatsu
authors: Research Laboratories, Nippon Menard Cosmetic, Aichi, Japan.|Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan.
authors: Seiji
authors: S
authors: Hasegawa
authors: Department of Applied Cell and Regenerative Medicine, Fujita Health University School of Medicine, Aichi, Japan.|Research Laboratories, Nippon Menard Cosmetic, Aichi, Japan.|Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan.
authors: Takaaki
authors: T
authors: Yamada
authors: Research Laboratories, Nippon Menard Cosmetic, Aichi, Japan.
authors: Hiroshi
authors: H
authors: Mizutani
authors: Research Laboratories, Nippon Menard Cosmetic, Aichi, Japan.
authors: Satoru
authors: S
authors: Nakata
authors: Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan.
authors: Akiko
authors: A
authors: Yagami
authors: Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan.
authors: Kayoko
authors: K
authors: Matsunaga
mesh_terms: D000293:Adolescent; D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D015595:Skin Aging / Q000473:pathology*; D055815:Young Adult
chemical_list: C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor
keywords: CD271 (p75NTR); aging; dermal stem cell; epidermal stem cell; skin stem cell