title: Pemetrexed induced a durable response in heavily pretreated metastatic extramammary Paget's disease.
abstract: OBJECTIVE
  Extramammary Paget's disease (EMPD) is a rare neoplasm with only a limited number of cases reported in the literature. Little was known about the availability of systemic chemotherapy for metastatic EMPD.
  
  
  METHODS
  We report one case of heavily pretreated EMPD with multiple organ metastases and successfully treated by pemetrexed.
  
  
  RESULTS
  The tumor was progression after multi-line therapy including erlotinib, radiotherapy, combined chemotherapy and radioactive particles implantation. Pemetrexed monotherapy was applied and progression free survival of more than 5 months with partial remission (PR) response was achieved. Only 1 time of grade 3 neutropenia was observed during the pemetrexed chemotherapy.
  
  
  CONCLUSIONS
  Due to the significant response and tolerability in the present case, pemetrexed monotherapy was recommended as a potent candidate for patients with advanced EMPD.
authors: Department of Oncology, Chinese PLA General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors: Chao
authors: C
authors: Wu
authors: Department of Oncology, Chinese PLA General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors: Hai-Tao
authors: HT
authors: Tao
authors: Department of Health Academy, Chinese PLA General Hospital 28 Fuxing Road.
authors: Fang-Fang
authors: FF
authors: Li
authors: Department of Internal Nedicine, No.1 Rongjun Hospital of Guangdong Province Xingangxi Road, Haizhu District, Guangzhou, 510260, China.
authors: Shang-Wu
authors: SW
authors: Huang
authors: Department of Oncology, Chinese PLA General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors: Wei-Wei
authors: WW
authors: Dong
authors: Department of Oncology, Chinese PLA General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors: Jin-Liang
authors: JL
authors: Wang
authors: Department of Oncology, Chinese PLA General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors: Yi
authors: Y
authors: Hu
authors: Department of Oncology, Chinese PLA General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors: Fang
authors: F
authors: Li
keywords: Pemetrexed; cutaneous adenocarcinoma; extramammary paget’s disease