title: Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis in the elderly.
abstract: BACKGROUND
  Peritoneal carcinomatosis is life-threatening without cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC). Only a few studies in the literature addressed the relationship between age and outcomes of peritonectomy. This study was designed to review the clinical outcomes in elderly patients who underwent CRS and PIC.
  
  
  METHODS
  This is a retrospective study of prospectively collected data of 611 consecutive patients with peritoneal carcinomatosis who underwent CRS and PIC by the same surgical team at St George Hospital in Sydney, Australia, between January 1996 and December 2013. Patients were divided into two groups; group 1 (<65 years old, n = 487) and group 2 (≥ 65 years old, n = 124). Subgroup analysis was performed in patients who were ≥75 years old (n = 20). A significant difference was defined as p < 0.05.
  
  
  RESULTS
  There was no significant statistical difference in terms of mean total hospital stay, intensive care unit stay, high dependency unit stay and complication rates. Postoperative mortality was 2 and 3 % in groups 1 and 2, respectively. Overall survival did not reach a statistical significance between the two groups. In subgroup analysis, patients showed similar morbidity results to patients who were <65 years old.
  
  
  CONCLUSIONS
  CRS and PIC can be safely done in the elderly. Age alone should not be the single exclusion criterion but rather taken into consideration along with other factors to determine the suitability of elderly patients.
authors: St George Clinical School, University of New South Wales, St George Hospital, New South Wales, Australia. yeqian.huang@outlook.com.
authors: Yeqian
authors: Y
authors: Huang
authors: Department of Surgery, University of New South Wales, St George Hospital, New South Wales, Australia. nayefalhariri@hotmail.com.|College of Medicine, Imam Muhammad ibn Saud Islamic University, Riyadh, Saudi Arabia. nayefalhariri@hotmail.com.
authors: Nayef A
authors: NA
authors: Alzahrani
authors: Department of Surgery, University of New South Wales, St George Hospital, New South Wales, Australia. dr.salehalzahrani@yahoo.com.
authors: Saleh E
authors: SE
authors: Alzahrani
authors: Department of Surgery, University of New South Wales, St George Hospital, New South Wales, Australia. Jing.Zhao@sesiahs.health.nsw.gov.au.
authors: Jing
authors: J
authors: Zhao
authors: Department of Medical Oncology, St George Hospital, Sydney, New South Wales, Australia. winston.liauw@sesiahs.health.nsw.gov.au.
authors: Winston
authors: W
authors: Liauw
authors: Department of Surgery, University of New South Wales, St George Hospital, New South Wales, Australia. david.morris@unsw.edu.au.|Hepatobiliary and Surgical Oncology Unit, Department of Surgery, St George Hospital, University of New South Wales, Level 3 Pitney Building, Gray Street, Kogarah, Sydney, NSW, 2217, Australia. david.morris@unsw.edu.au.
authors: David L
authors: DL
authors: Morris
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D065426:Cytoreduction Surgical Procedures / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019990:Perioperative Care; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult