title: Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes.
abstract: Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are extremely rare. In this review, we focused on genes whose overexpression prolongs the life of fruit flies. The majority of longevity-associated genes regulates metabolism and stress resistance, and belongs to the IGF-1R, PI3K, PKB, AMPK and TOR metabolic regulation cluster and the FOXO, HDAC, p53 stress response cluster.
authors: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Institute of Biology of Komi Science Center of Ural Branch of RAS, 167982 Syktyvkar, Russia.
authors: Ekaterina N
authors: EN
authors: Proshkina
authors: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Institute of Biology of Komi Science Center of Ural Branch of RAS, 167982 Syktyvkar, Russia.
authors: Mikhail V
authors: MV
authors: Shaposhnikov
authors: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
authors: Asiya F
authors: AF
authors: Sadritdinova
authors: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
authors: Anna V
authors: AV
authors: Kudryavtseva
authors: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia. Electronic address: amoskalev@ib.komisc.ru.
authors: Alexey A
authors: AA
authors: Moskalev
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster; D006801:Humans; D008136:Longevity / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins
keywords: Drosophila melanogaster; Overexpression; Pro-longevity genes