title: Role of Suppressor of Cytokine Signaling 3 in the Immune Modulation of Mesenchymal Stromal Cells.
abstract: The underlying mechanisms of mesenchymal stromal cells (MSCs) on immune modulation to treat allergic diseases remain unclear. Here, we showed that the suppressor of cytokine signaling 3 (SOCS3) is an important immune modulator expressed by MSCs, which is significantly increased by interferon-γ (IFN-γ). In addition, we observed that SOCS3 is a crucial mediator of the anti-proliferative and functional effects of MSCs on T cells and B cells. The immune modulation of MSCs through SOCS3 is mediated by cell-cell contacts. Moreover, SOCS3 could serve as an indicator to predict the potential immune modulatory of MSCs derived from different donors. Furthermore, treatment with anti-SOCS3 Ab significantly decreased ovalbumin-specific antibodies and neutrophil infiltration in ovalbumin-induced allergic rhinitis (AR) mice. Our results suggest that SOCS3 serves as an immune modulator interfering with T cells and B cells, and SOCS3 may act as a predictive marker for immune modulatory of MSCs.
authors: Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai, 200031, China.|Department of Otolaryngology, Ruijin Hospital, School of medicine, Shanghai Jiao Tong University, 197 Ruijiner Road, Huangpu District, Shanghai, 200025, China.
authors: Chen
authors: C
authors: Yang
authors: Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai, 200031, China. cqzheng1@163.com.
authors: Chunquan
authors: C
authors: Zheng
authors: Department of Otolaryngology, The Sixth People's Hospital, School of medicine, Shanghai Jiao tong University, 600 Yishan Road, Xuhui District, Shanghai, 200233, China.
authors: Hai
authors: H
authors: Lin
authors: Department of Otolaryngology, First People's Hospital of Hangzhou City, Hangzhou, Zhejiang Province, 310006, China.
authors: Jing
authors: J
authors: Li
authors: Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai, 200031, China.
authors: Keqing
authors: K
authors: Zhao
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D056747:Immunomodulation / Q000187:drug effects*; D007371:Interferon-gamma / Q000494:pharmacology*; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D020556:Neutrophil Infiltration / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D065631:Rhinitis, Allergic / Q000276:immunology*; D000071223:Suppressor of Cytokine Signaling 3 Protein / Q000096:biosynthesis / Q000276:immunology*
chemical_list: C491411:Socs3 protein, mouse; D000071223:Suppressor of Cytokine Signaling 3 Protein; D007073:Immunoglobulin E; D007371:Interferon-gamma; D010047:Ovalbumin
keywords: SOCS3; immune modulatory; interferon-γ; mesenchymal stromal cells