title: Comparison of 3-Year Outcomes for Coronary Artery Bypass Graft Surgery and Drug-Eluting Stents: Does Sex Matter?
abstract: BACKGROUND
  Several randomized controlled trials and observational studies have compared outcomes for coronary artery bypass graft (CABG) surgery and drug-eluting stents (DES), but these studies have not thoroughly investigated the relative difference in outcomes by sex. We aimed to compare 3-year outcomes (mortality, mortality/myocardial infarction/stroke, and repeat revascularization) for CABG surgery and percutaneous coronary interventions with DES by sex.
  
  
  METHODS
  A total of 4,532 women (2,266 pairs of CABG and DES patients) and 11,768 men (5,884 pairs) were propensity matched separately using multiple patient risk factors and were compared with respect to 3-year outcomes.
  
  
  RESULTS
  Both women and men receiving DES had significantly higher mortality rates (adjusted hazard ratio, 1.28; 95% confidence interval, 1.06 to 1.54 and adjusted hazard ratio, 1.22; 95% confidence interval, 1.06 to 1.41, respectively) and myocardial infarction/mortality/stroke rates (adjusted hazard ratio, 1.40; 95% confidence interval, 1.19 to 1.64 and adjusted hazard ratio, 1.36; 95% confidence interval, 1.20 to 1.54, respectively) with DES. The advantage for CABG surgery was also present for several preselected patient subgroups. Men had consistently lower adverse outcome rates than women for both procedures. For example, the mortality rates for CABG and DES for men were 8.0% and 9.1%, compared with respective rates of 11.8% and 13.7% for women.
  
  
  CONCLUSIONS
  For women, the advantage of CABG surgery over DES is very similar to what was found for men, and this advantage persisted for patients with and without high-risk characteristics.
authors: School of Public Health, University at Albany, State University of New York, Albany, New York. Electronic address: edward.hannan@health.ny.gov.
authors: Edward L
authors: EL
authors: Hannan
authors: School of Public Health, University at Albany, State University of New York, Albany, New York.
authors: Ye
authors: Y
authors: Zhong
authors: Department of Medicine, Penn State College of Medicine, Hershey, Pennsylvania.
authors: Chuntao
authors: C
authors: Wu
authors: Department of Cardiology, Boston Medical Center, Boston, Massachusetts.
authors: Alice K
authors: AK
authors: Jacobs
authors: Department of Cardiology, United Health Services, Binghamton, New York.
authors: Nicholas J
authors: NJ
authors: Stamato
authors: Department of Cardiology, Mt. Sinai Medical Center, New York, New York.
authors: Samin
authors: S
authors: Sharma
authors: University of Nebraska Medical Center, Omaha, Nebraska.
authors: Jeffrey P
authors: JP
authors: Gold
authors: Department of Cardiothoracic Surgery, Drexel University, Philadelphia, Pennsylvania.
authors: Andrew S
authors: AS
authors: Wechsler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D001026:Coronary Artery Bypass / Q000379:methods*; D003324:Coronary Artery Disease / Q000401:mortality / Q000601:surgery*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome