title: Meta-analysis on autologous stem cell transplantation in the treatment of limb ischemic.
abstract: OBJECTIVE
  Meta-analysis on the effectiveness of the autologous stem cell transplantation in curing limb ischemic.
  
  
  METHODS
  Consulting papers relate to the autologous stem cell transplantation in curing limb ischemic in PubMed, CNKI, Wan-fang Data and VIP. Based on include and exclude standards, we arrange at least 2 evaluators sifting these papers separately, doing Quality evaluation and information extraction and then cross checking. Negotiate through a third party if any disagreement comes out. Review Manager 4.2 is used in Meta-analysis.
  
  
  RESULTS
  Involved 7 papers, all in English version. Patients involved all diagnosed as critical limb ischemia (CLI). Results show that no adverse reaction occurred during this study. Amputation rate in patients with stem cell group treatment is lower than control group (P < 0.05). And no notable difference in improving ABI (P > 0.05).
  
  
  CONCLUSIONS
  Applying autologous stem cell transplantation in curing limb ischemic does not have obviously effectiveness in the improvement of ABI of the limb ischemic patients. But it can dramatically reduce the rate of amputation. So autologous stem cell transplantation is a good and safe choice for patients have no choice but amputation.
authors: Department of Endocrinology and Metabolism, Anzhen Hospital of Beijing Affiliated to Capital Medical University Beijing, China.
authors: Xiuqin
authors: X
authors: Sun
authors: Department of Orthopedics, Puren Hospital of Beijing China.
authors: Jilin
authors: J
authors: Ying
authors: Department of Endocrinology, The First Hospital of Dandong Liaoning, China.
authors: Yunan
authors: Y
authors: Wang
authors: Department of General Surgery, Changhai Hospital Affiliated to The Second Military Medical University Shanghai, China.
authors: Wei
authors: W
authors: Li
authors: Department of General Surgery, The First Hospital of Dandong Liaoning, China.
authors: Yaojiang
authors: Y
authors: Wu
authors: Department of Endocrinology, The First Hospital of Dandong Liaoning, China.
authors: Baoting
authors: B
authors: Yao
authors: Department of Endocrinology, The First Hospital of Dandong Liaoning, China.
authors: Ying
authors: Y
authors: Liu
authors: Department of General Surgery, General Hospital of Armed Police Beijing, China.
authors: Hongkai
authors: H
authors: Gao
authors: Department of Endocrinology and Metabolism, International Hospital of Peking University Beijing, China.
authors: Xiaomei
authors: X
authors: Zhang
keywords: Stem cell; limb ischemic; meta-analysis