title: The Role of Cardiolipin in Cardiovascular Health.
abstract: Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests clinically as cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the gene encoding tafazzin, the transacylase that carries out the second CL remodeling step. In addition to BTHS, CL is linked to other cardiovascular diseases (CVDs), including cardiomyopathy, atherosclerosis, myocardial ischemia-reperfusion injury, heart failure, and Tangier disease. The link between CL and CVD may possibly be explained by the physiological roles of CL in pathways that are cardioprotective, including mitochondrial bioenergetics, autophagy/mitophagy, and mitogen activated protein kinase (MAPK) pathways. In this review, we focus on the role of CL in the pathogenesis of CVD as well as the molecular mechanisms that may link CL functions to cardiovascular health.
authors: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
authors: Zheni
authors: Z
authors: Shen
authors: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA ; Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, USA.
authors: Cunqi
authors: C
authors: Ye
authors: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
authors: Keanna
authors: K
authors: McCain
authors: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
authors: Miriam L
authors: ML
authors: Greenberg
mesh_terms: D056889:Barth Syndrome / Q000235:genetics / Q000473:pathology; D002308:Cardiolipins / Q000235:genetics* / Q000378:metabolism; D009202:Cardiomyopathies / Q000235:genetics / Q000473:pathology; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002319:Cardiovascular System / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051336:Mitochondrial Membranes / Q000378:metabolism* / Q000473:pathology; D020929:Mitogen-Activated Protein Kinase Kinases / Q000235:genetics; D015398:Signal Transduction
chemical_list: D002308:Cardiolipins; D020929:Mitogen-Activated Protein Kinase Kinases