title: Analysis of prognostic factors in lymphoma patients with bone marrow involvement: a single center cohort study.
abstract: The objective of this study was to explore prognostic factors in lymphoma patients with bone marrow involvement (Ann Arbor stage IV). To that end, we analyzed a cohort study of 68 stage IV lymphoma patients. We found that the most predictive thresholds for lymphocyte rate, monocyte rate, and lymphocyte to monocyte ratio (LMR) were 30%, 13%, and 3, respectively. A lymphocyte rate <30%, a monocyte rate >13%, and the presence of B symptoms were associated with shorter OS. LMR >3, Eastern Oncology Cooperative Group performance status ≤1, indolent lymphoma, and B cell (as opposed to T and NK cell) lymphoma predicted longer OS. Our study showed that these basic, easily acquired data can predict the outcome and overall survival in lymphoma patients with bone marrow involvement. These prognostic markers should be taken into consideration when devising new prognostic scoring systems for lymphomas.
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Xing
authors: X
authors: Xin
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Zhaojun
authors: Z
authors: Liu
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Fankai
authors: F
authors: Meng
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Wen
authors: W
authors: Zeng
authors: Department of Training, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Ming
authors: M
authors: Tian
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Ningning
authors: N
authors: Miao
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Jia
authors: J
authors: Wei
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Hanying
authors: H
authors: Sun
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Jianfeng
authors: J
authors: Zhou
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People's Republic of China.
authors: Lifang
authors: L
authors: Huang
keywords: International prognostic index; ann arbor stage IV; bone marrow involvement; lymphoma; overall survival; prognostic factor