title: Impact of chromosome 12p13 variants on ischemic stroke risk.
abstract: BACKGROUND
  In 2009, a genome-wide association study (GWAS) identified two variants (rs12425791 and rs11833579) near NINJ2 gene that confer susceptibility to stroke in Caucasian populations. Recently, a number of studies have been conducted to replicate this finding in Asian populations. However, the results are conflicting. Thus, we performed a quantitative analysis to summarize the evidence regarding the association between these two polymorphisms and ischemic stroke risk.
  
  
  METHODS
  Pertinent studies were identified by searching PubMed and Embase through September 2014. Studies that reported odds ratio (OR) with 95% confidence interval (CI) for the association between these two polymorphisms and stroke risk were included.
  
  
  RESULTS
  Eight independent publications, with 8626 cases and 8046 controls for rs12425791 and 9142 cases and 8657 controls for rs11833579, were included. Overall, significantly increased ischemic stroke risk was associated with rs12425791 A allele when all studies were pooled into the meta-analysis (AA/GA vs. GG: OR = 1.08, 95% CI: 1.01-1.14). However, rs11833579 was not associated with increased stroke risk in any genetic model.
  
  
  CONCLUSIONS
  These findings indicate that rs12425791 G>A polymorphism may be a low-penetrance susceptibility marker of stroke in Asian populations and further studies are warranted to verify this association.
authors: a 1 Department of Neurology, Jinling Hospital , Medical School of Nanjing University , Nanjing , Jiangsu Province , China.
authors: Zhizhong
authors: Z
authors: Zhang
authors: a 1 Department of Neurology, Jinling Hospital , Medical School of Nanjing University , Nanjing , Jiangsu Province , China.
authors: Gelin
authors: G
authors: Xu
authors: b 2 Department of Environmental Health, Harvard School of Public Health , Harvard University , Boston , MA , USA.
authors: Yongyue
authors: Y
authors: Wei
authors: a 1 Department of Neurology, Jinling Hospital , Medical School of Nanjing University , Nanjing , Jiangsu Province , China.
authors: Wusheng
authors: W
authors: Zhu
authors: a 1 Department of Neurology, Jinling Hospital , Medical School of Nanjing University , Nanjing , Jiangsu Province , China.
authors: Xiaobing
authors: X
authors: Fan
authors: a 1 Department of Neurology, Jinling Hospital , Medical School of Nanjing University , Nanjing , Jiangsu Province , China.
authors: Xinfeng
authors: X
authors: Liu
mesh_terms: D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000235:genetics*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D011110:Polymorphism, Genetic; D012306:Risk; D020521:Stroke / Q000235:genetics*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; C504206:NINJ2 protein, human
keywords: GWAS; NINJ2; polymorphism; stroke