title: A Versatile Monoclonal Antibody Specific Against Human DAB2IP.
abstract: Human DAB2 interaction protein (DAB2IP) is a member of Ras-GTPase activating protein family and functions as a tumor suppressor, implying it could serve as a prognostic biomarker in cancers. Here we generated a mouse monoclonal antibody, 2A4, directed against human DAB2IP. This antibody was identified as IgG1 and specifically recognizes DAB2IP in both its native and denatured forms. It will serve as a useful and versatile tool for further mechanistic study and development of the potential prognostic significance of DAB2IP.
authors: 1 State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter , Chinese Academy of Sciences, Fuzhou, China .
authors: Yintao
authors: Y
authors: Su
authors: 2 Department of Physiology, Fujian University of Traditional Chinese Medicine , Fuzhou, China .
authors: Fangyuan
authors: F
authors: Shi
authors: 3 Freshwater Fisheries Research Institute of Fujian Province , Fuzhou, China .
authors: Zhanzhuang
authors: Z
authors: Zeng
authors: 1 State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter , Chinese Academy of Sciences, Fuzhou, China .
authors: Xiuling
authors: X
authors: Wu
authors: 1 State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter , Chinese Academy of Sciences, Fuzhou, China .
authors: Yanhe
authors: Y
authors: Zhao
authors: 1 State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter , Chinese Academy of Sciences, Fuzhou, China .
authors: Lei
authors: L
authors: Zhang
authors: 2 Department of Physiology, Fujian University of Traditional Chinese Medicine , Fuzhou, China .
authors: Zuofu
authors: Z
authors: Xie
authors: 1 State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter , Chinese Academy of Sciences, Fuzhou, China .
authors: Yunkun
authors: Y
authors: Wu
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000276:immunology; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008807:Mice, Inbred BALB C; D011379:Prognosis; D020703:ras GTPase-Activating Proteins / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; C462952:DAB2IP protein, human; D007074:Immunoglobulin G; D020703:ras GTPase-Activating Proteins