title: The long-term outlook to final outcome and steroid treatment results in children with idiopathic nephrotic syndrome.
abstract: Idiopathic Nephrotic Syndrome (INS) was defined as combination of a nephrotic syndrome and non-specific histological abnormalities of the kidney. Among these abnormalities, minimal change nephrotic syndrome (MCNS) is the most common. We report our experience with MCNS; its clinical course, treatments and outcomes. One-hundred twenty children (66 male, 54 female) with MCNS, admitted to Nephrology Department between 1987-2009 was assessed. Their clinical presentations, treatment and disease courses were reviewed. The mean duration of follow-up was 11.5 ± 1.9 years. Initially, all patients given prednisone 2 mg/kg/ day single dose per four weeks a followed by eight weeks of the same daily dose given every other day. After week 12, prednisone was progressively tapered off at the rate of 0.5 mg/kg per 15 daily intervals until complete discontinuation had been achieved by week 16. Steroid resistance was accepted as no achievement of remission following four weeks of prednisone 2 mg/kg/day followed by three intravenous pulses of corticosteroids. At the end of the initial steroid treatment, 106 (88.3%) patients were determinate steroid responsive while 14 (11.7%) patients were steroid resistance. Thirty-eight patients underwent biopsy. At the end of study recovery rate was increased from 88.3% to 94.1%. In conclusion, most of patients entered remission by our therapy end of follow up time. With the support of our satisfactory results among the whole study group, long-term prednisolone treatment still remains valid.
authors: a Department of Pediatric Nephrology , Ankara Children Health and Research Hematology Oncology Education Research Hospital , Ankara , Turkey .
authors: Nida
authors: N
authors: Dinçel
authors: b Department of Pediatric Nephrology , Dr. Behcet Uz Children Diseases Teaching and Research Hospital , Izmir , Turkey , and.
authors: Ebru
authors: E
authors: Yılmaz
authors: c Department of Pediatric Nephrology, Medical Faculty , Ege University , Izmir , Turkey.
authors: İpek
authors: İ
authors: Kaplan Bulut
authors: c Department of Pediatric Nephrology, Medical Faculty , Ege University , Izmir , Turkey.
authors: Şükriye
authors: Ş
authors: Hacıkara
authors: c Department of Pediatric Nephrology, Medical Faculty , Ege University , Izmir , Turkey.
authors: Sevgi
authors: S
authors: Mir
mesh_terms: D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D018450:Disease Progression; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology*; D008297:Male; D015999:Multivariate Analysis; D009402:Nephrosis, Lipoid / Q000188:drug therapy* / Q000453:epidemiology*; D011241:Prednisone / Q000008:administration & dosage*; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D013995:Time; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D003520:Cyclophosphamide; D011241:Prednisone
keywords: Children; idiopathic nephrotic syndrome; long-term outcome; minimal change