title: Duration of antiplatelet therapy cessation before coronary artery bypass surgery: Relation with platelet count.
abstract: As of now, no study or data is available to determine the period of discontinuation of antiplatelet therapy and the timing of elective surgery in clopidogrel treated patients. The 2011 ACCF/AHA Guidelines have a Class-I recommendation for withdrawing clopidogrel for 5 days before elective coronary artery bypass grafting. However, 5 days period may not suit all patients as platelet count varies from 150 × 10(9)/L to 450 × 10(9)/L. Based on our retrospective data analysis, we have proposed a hypothesis to determine no of days of discontinuation of antiplatelet therapy while taking in consideration the basal count and life-span of platelets.
authors: Professor, Department of Anaesthesiology and Intensive Care, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, U.P., India. Electronic address: ambeshsp@yahoo.com.
authors: Sushil Prakash
authors: SP
authors: Ambesh
authors: Resident, Department of General Medicine, Moti Lal Nehru Medical College, Allahabad 211002, U.P., India.
authors: Paurush
authors: P
authors: Ambesh
authors: Professor, Department of Cardiovascular and Thoracic Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, U.P., India.
authors: Shantanu
authors: S
authors: Pande
authors: Professor, Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, U.P., India.
authors: Aditya
authors: A
authors: Kapoor
mesh_terms: D000328:Adult; D000368:Aged; D000077144:Clopidogrel; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D012189:Retrospective Studies; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: Antiplatelet therapy; Aspirin; Clopidogrel; Coronary artery bypass grafting; Platelets