title: [Efficacy Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Children with Severe Aplastic Anemia].
abstract: OBJECTIVE
  To study the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with severe aplastic anemia (SAA).
  
  
  METHODS
  A total of 11 children with SAA were treated with HLA matched siblings (n = 7), umbilical cord blood (n = 2) and haploidentical HSCT (n = 2).
  
  
  RESULTS
  Among 11 children patients, 10 patients achieved engraftment, but 3 children patients experienced secondary graft failure, after donor lymphocyte infusions (DLI), they achieved engraftment again. One patient received cord blood transplantation and experienced primary graft rejection, but acquired autologous recovery. The median time for neutrophils to reach over 0.5 × 10(9)/L was 14 days (10-19 days) in the 9 children received bone marrow or bone marrow and peripheral blood allo-HSCT, while the median time for platelets to reach over 20 × 10(9)/L was 17 days (8-42 days). For the patient received double cord blood transplantation, the time of neutrophile and platelet level recovery was 16 days and 41 days, respectively.
  
  
  CONCLUSIONS
  If HLA-matched sibling donor is available, allo-HSCT can be recommended as the first line of treatment for children with SAA. It is feasible for children with SAA to receive allo-HSCT from selective donor, including cord blood and haploidentical HSCT. Donor lymphocyte infusions can improve engraftment.
authors: Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China.
authors: Pei-Fang
authors: PF
authors: Xiao
authors: Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China.
authors: Shao-Yan
authors: SY
authors: Hu
authors: Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China.
authors: Hai-Long
authors: HL
authors: He
authors: Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China.
authors: Jun
authors: J
authors: Lu
authors: Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China.
authors: Jie
authors: J
authors: Li
authors: Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China . E-mail: cyh_1949@aliyun.com.
authors: Yi-Huan
authors: YH
authors: Chai
mesh_terms: D064591:Allografts; D000741:Anemia, Aplastic; D002648:Child; D006084:Graft Rejection; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D035781:Siblings; D014019:Tissue Donors