title: Lipoxin A4 and Neutrophil/Lymphocyte Ratio: A Possible Indicator in Achieved Systemic Risk Factors for Periodontitis.
abstract: BACKGROUND
  The aim of this study was to evaluate the serum lipoxin A4 (LXA4) and neutrophil/lymphocyte (Ne/Ly) ratio in individuals with achieved systemic risk factors for periodontitis.
  
  
  METHODS
  One hundred and eighty volunteers (69 male, 111 female) who were categorized as systemically healthy control, diabetes, hyperlipidemia, obese and menopause were recruited for this cross-sectional study. Sociodemographic characteristics and oral health behaviors were recorded via questionnaire. Clinical periodontal parameters, including plaque index (PI), gingival index (GI), probing pocket depth (PD), clinical attachment level (CAL), sulcus bleeding index (SBI) and decayed, missing, and filled teeth index (DMFT), were assessed. Systemic parameters and LXA4 levels were evaluated in serum samples.
  
  
  RESULTS
  Clinical periodontal parameters and DMFT were higher in subjects with achieved systemic risk factors than in healthy subjects. The systemically healthy with periodontitis group had higher serum LXA4 levels than the systemically healthy with non-periodontitis group (P<0.05). The Ne/Ly ratio was higher in the hyperlipidemic group with periodontitis than in the hyperlipidemic group with non-periodontitis (P<0.05). In the control group, serum LXA4 levels were positively correlated with the PD, CAL and SBI.
  
  
  CONCLUSIONS
  In the presence of periodontitis, an increase in LXA4 levels and the Ne/Ly ratio in hyperlipidemic patients could contribute to the hypothesis that these parameters could be an indicator in periodontitis and its systemic risk factors.
authors: Department of Periodontology, Faculty of Dentistry, Mustafa Kemal University, Hatay, Turkey.
authors: Burak
authors: B
authors: Doğan
authors: Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey.
authors: Özlem
authors: Ö
authors: Fentoğlu
authors: Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey.
authors: Fatma Yeşim
authors: FY
authors: Kırzıoğlu
authors: Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey.
authors: Esra Sinem
authors: ES
authors: Kemer
authors: Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors: Banu Kale
authors: BK
authors: Köroğlu
authors: Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors: Oğuzhan
authors: O
authors: Aksu
authors: Department of Microbiology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors: Süleyman Akif
authors: SA
authors: Çarsancaklı
authors: Department of Biostatistics and Medical Informatics, Süleyman Demirel University, Faculty of Medicine, Isparta, Turkey.
authors: Hikmet
authors: H
authors: Orhan
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D044045:Lipoxins / Q000097:blood*; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010518:Periodontitis / Q000097:blood* / Q000209:etiology*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D044045:Lipoxins; C040527:lipoxin A4