title: Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 Years Old.
abstract: OBJECTIVE
  To evaluate the association of birthweight and weight gain during different periods in childhood with the prevalence of hypertriglyceridemic waist phenotype (HWP).
  
  
  METHODS
  In 1982, all hospitals births in Pelotas, South Brazil, were identified, and the 5914 liveborn were examined and their mothers interviewed. This population has been followed for several times. In 2004-05, we tried to follow the whole cohort and the subjects were interviewed, examined, and a blood sample was collected. HWP was defined as a triglycerides ≥ 2 mmol/L and a waist circumference ≥ 90 cm for men, and triglycerides ≥ 1.5 mmol/L and waist circumference ≥ 85 cm for woman. Poisson regression with robust adjustment of the variance was used to obtain adjusted estimates of the prevalence ratio.
  
  
  RESULTS
  Subjects whose weight-for-age z-score at mean age of 42 months was one or more standard deviation above the mean, according to gender and age, were 8.77 (95% confidence interval: 2.60; 29.64) times more likely of presenting the HWP than those subjects whose weight-for-age z-score at 42 months was more than one standard deviation below the mean. Among those subjects whose birthweight was adequate-for-gestational age (AGA), conditional weight at 20 months was positively associated to the risk of HWP [relative risk: 1.59 (95%: confidence interval: 1.32; 1.92)], whereas for small for gestational age (SGA) subjects conditional weight was not associated with HWP [relative risk: 1.05 (95% confidence interval: 0.77; 1.43)], p-value for interaction 0.08.
  
  
  CONCLUSIONS
  Early weight gain among SGA infants, did not increase the risk of HWP in early adulthood, whereas among those who were AGA, early weight gain increased the risk of the having the phenotype in early adulthood.
authors: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas-RS, Brazil.
authors: Ricardo Lanzetta
authors: RL
authors: Haack
authors: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas-RS, Brazil.
authors: Bernardo Lessa
authors: BL
authors: Horta
authors: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas-RS, Brazil.
authors: Denise Petrucci
authors: DP
authors: Gigante
authors: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas-RS, Brazil.
authors: Fernando C
authors: FC
authors: Barros
authors: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas-RS, Brazil.
authors: Isabel
authors: I
authors: Oliveira
authors: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas-RS, Brazil.
authors: Vera M F
authors: VM
authors: Silveira
mesh_terms: D000293:Adolescent; D001724:Birth Weight; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D064250:Hypertriglyceridemic Waist / Q000453:epidemiology / Q000503:physiopathology*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010641:Phenotype; D015430:Weight Gain; D055815:Young Adult