title: Soft tissue fillers as non-specific modulators of adipogenesis: change of the paradigm?
abstract: Dermal filler injection is a cornerstone of facial rejuvenation procedures. Based on available data in animal and human studies, we suppose that the activation and proliferation of adipose-derived stem cells and expansion of mature adipocytes play a crucial role in long-term effects of volumizing, tissue tightening and beautification.
authors: Wellcomet GmbH, Karlsruhe, Germany.
authors: Ilja L
authors: IL
authors: Kruglikov
authors: Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.
authors: Uwe
authors: U
authors: Wollina
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000502:physiology; D050156:Adipogenesis / Q000502:physiology*; D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage; D049109:Cell Proliferation; D003094:Collagen / Q000008:administration & dosage / Q000096:biosynthesis; D000067548:Dermal Fillers / Q000008:administration & dosage*; D005145:Face; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage; D008954:Models, Biological; D012060:Rejuvenation; D015595:Skin Aging
chemical_list: D001672:Biocompatible Materials; D000067548:Dermal Fillers; D006820:Hyaluronic Acid; D003094:Collagen
keywords: adipose-derived stem cells; longevity; soft tissue fillers