title: Architectural and Functional Commonalities between Enhancers and Promoters.
abstract: With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.
authors: Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA. Electronic address: taekyung.kim@utsouthwestern.edu.
authors: Tae-Kyung
authors: TK
authors: Kim
authors: University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Department of Human Genetics, Biomedical Research Building, Room 719, 1501 NW 10(th) Avenue, Miami, FL 33136, USA. Electronic address: rshiekhattar@med.miami.edu.
authors: Ramin
authors: R
authors: Shiekhattar
mesh_terms: D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D011401:Promoter Regions, Genetic; D062085:RNA, Long Noncoding / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D062085:RNA, Long Noncoding; D014157:Transcription Factors; D012321:DNA-Directed RNA Polymerases