title: Changes in the hemolytic activity of Candida species by common electrolytes.
abstract: BACKGROUND
  Hemolysins are crucial virulence factors which help pathogens to survive and persist in the host. This study investigated whether common electrolytes will affect the hemolysins of Candida species. The hemolysins from 25 Candida isolates were investigated using a plate specially designed for Candida species in the presence of three electrolytes, CaCl2, NaCl and KCl, at different concentrations. The hemolytic activity was determined after 48 h and the hemolytic index was calculated.
  
  
  RESULTS
  All three electrolytes caused a decrease in the hemolytic activity. Significant differences existed between varying concentrations of NaCl, while no significant differences existed for the CaCl2 and KCl groups. Additionally, the peripheral hemolytic index was highly correlated with the hemolytic index (r = 0.656, p < 0.001).
  
  
  CONCLUSIONS
  Our findings indicate that electrolytes reduce hemolysis by Candida species and a correlation exists between the peripheral hemolytic index and the translucent hemolytic index.
authors: Department of Microbiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China. wanlei1987@hotmail.com.|Department of Periodontology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China. wanlei1987@hotmail.com.
authors: Lei
authors: L
authors: Wan
authors: Key Laboratory of Oral Medicine,Guangzhou Institute of Oral Disease,Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China. gangluo@139.com.
authors: Gang
authors: G
authors: Luo
authors: Department of Periodontology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China. luhaibin-007@163.com.
authors: Haibin
authors: H
authors: Lu
authors: Department of Periodontology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China. xuanxuan187@126.com.
authors: Dongying
authors: D
authors: Xuan
authors: Department of Microbiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China. gzhcao@smu.edu.cn.
authors: Hong
authors: H
authors: Cao
authors: Department of Periodontology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China. jincaizhang@live.cn.
authors: Jincai
authors: J
authors: Zhang
mesh_terms: D002122:Calcium Chloride / Q000378:metabolism; D002175:Candida / Q000187:drug effects* / Q000378:metabolism*; D003470:Culture Media / Q000737:chemistry; D004573:Electrolytes / Q000378:metabolism*; D006460:Hemolysin Proteins / Q000378:metabolism*; D006801:Humans; D008828:Microbiological Techniques; D011189:Potassium Chloride / Q000378:metabolism; D012965:Sodium Chloride / Q000378:metabolism
chemical_list: D003470:Culture Media; D004573:Electrolytes; D006460:Hemolysin Proteins; D012965:Sodium Chloride; D011189:Potassium Chloride; D002122:Calcium Chloride