title: Macrocarpal-like Compounds from Eugenia umbelliflora Fruits and Their Antibacterial Activity.
abstract: Certain members of the genus Eugenia are used as foods. One of these species is Eugenia umbelliflora, which is used for its fruits. The aim of the study was to isolate the constituents of the CH2Cl2 fraction obtained from E. umbelliflora O. Berg (Myrtaceae) and also to evaluate its antimicrobial properties. Two new meroterpenoids, eugenial C (3) and eugenial D (4) were isolated from the unripe fruits of E. umbelliflora and their structures established mainly by extensive NMR spectroscopy. In previous studies, the CH2Cl2 extract showed significant antibacterial activity, which can be attributed to meroterpenoids isolated in this study. The compounds eugenials C and D exhibited potent activity against Bacillus subtilis and Staphylococcus aureus and different strains of MRSA and activity similar to those of the antibiotics used in antimicrobial therapies.
authors: Centro de Ciências da Saúde, Universidade do Vale do Itajaı́ (UNIVALI) , Itajaı́, Santa Catarina State Brazil.
authors: Larissa Gabriela
authors: LG
authors: Faqueti
authors: Centro de Ciências da Saúde, Universidade do Vale do Itajaı́ (UNIVALI) , Itajaı́, Santa Catarina State Brazil.
authors: Ingrid Vicente
authors: IV
authors: Farias
authors: Centro de Ciências da Saúde, Universidade do Vale do Itajaı́ (UNIVALI) , Itajaı́, Santa Catarina State Brazil.
authors: Elem Cristina
authors: EC
authors: Sabedot
authors: Centro de Ciências da Saúde, Universidade do Vale do Itajaı́ (UNIVALI) , Itajaı́, Santa Catarina State Brazil.
authors: Franco
authors: F
authors: Delle Monache
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy-CIETUS, University of Salamanca , 37007, Salamanca, Spain.
authors: Arturo
authors: A
authors: San Feliciano
authors: Departamento de Quı́mica, Universidade Estadual de Maringá (UEM) , Maringá, Paraná State Brazil.
authors: Ivânia Teresinha Albrecht
authors: IT
authors: Schuquel
authors: Centro de Ciências da Saúde, Universidade do Vale do Itajaı́ (UNIVALI) , Itajaı́, Santa Catarina State Brazil.
authors: Valdir
authors: V
authors: Cechinel-Filho
authors: Centro de Ciências da Saúde, Universidade do Vale do Itajaı́ (UNIVALI) , Itajaı́, Santa Catarina State Brazil.
authors: Alexandre Bella
authors: AB
authors: Cruz
authors: Centro de Ciências da Saúde, Universidade do Vale do Itajaı́ (UNIVALI) , Itajaı́, Santa Catarina State Brazil.
authors: Christiane
authors: C
authors: Meyre-Silva
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D000068856:Eugenia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D010696:Phloroglucinol / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes; D013729:Terpenes; D010696:Phloroglucinol
keywords: Eugenia umbelliflora; Myrtaceae; antibacterial activity; eugenial C; eugenial D; phloroglucinol-sesquiterpene