title: Effects of Imbalance in Trace Element on Thyroid Gland from Moroccan Children.
abstract: The major environmental factor that determines goiter prevalence is iodine status. However, other trace elements like selenium and zinc can influence the thyroid function. Hair samples (n = 68) were collected from goitrous and non-goitrous children aged 8-12 years living in the area of Al Haouz Marrakech-(Morocco). Trace element concentrations (Cr, Fe, Mg, Zn, Se, I) in hair were measured using flame atomic absorption spectroscopy, graphite furnace atomic absorption spectroscopy, and inductively coupled plasma mass spectrometry. Difference in the mean concentration of each trace element between groups was determined by ANOVA test. The mean concentration levels of I, Se, and Zn for goitrous children were lower and were similar to the mean concentrations reported in the literature for subjects with goiter. The regression results gave us a better model that revealed significant positive relations between thyroid volume and Zn contents and significant negative relation with I and Se. The overall findings of the present study revealed that the actual factors of thyroid gland volume increase are I and Se deficiency. This work could shed some light on the effects of trace elements-other than iodine-on the thyroid disorders.
authors: Laboratory of Hydrobiology, Ecotoxicology and Sanitation, Bd Moulay Abdellah BP, 2390-40001, Marrakech, Morocco. s.elfadeli@yahoo.fr.
authors: Sana
authors: S
authors: El-Fadeli
authors: Laboratory of Human Ecology, Bd Moulay Abdellah BP, 2390-40001, Marrakech, Morocco.
authors: Sabir
authors: S
authors: Bouhouch
authors: P.G.Demidov Yaroslavl State University, Sovetskaya str. 14, Yaroslavl, 150000, Russia.|Trace Element - Insitute for UNESCO, 7 rue Guillaume Paradin, Lyon, France.
authors: Anatoly V
authors: AV
authors: Skalny
authors: Regional Laboratory of Epidemiological Diagnosis and Environmental Health, Marrakech, Morocco.
authors: Yassir
authors: Y
authors: Barkouch
authors: Laboratory of Toxicology and Industrial Hygiene, 1 rue Gaston Veil, 44035 Cedex 1, Nantes, France.
authors: Alain
authors: A
authors: Pineau
authors: Laboratory of Human Ecology, Bd Moulay Abdellah BP, 2390-40001, Marrakech, Morocco.
authors: Mohamed
authors: M
authors: Cherkaoui
authors: Laboratory of Hydrobiology, Ecotoxicology and Sanitation, Bd Moulay Abdellah BP, 2390-40001, Marrakech, Morocco.
authors: Azeddine
authors: A
authors: Sedki
mesh_terms: D002648:Child; D005260:Female; D006042:Goiter / Q000097:blood* / Q000453:epidemiology; D006197:Hair / Q000378:metabolism*; D006801:Humans; D008297:Male; D008954:Models, Biological; D009018:Morocco / Q000453:epidemiology; D009929:Organ Size; D015995:Prevalence; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology; D014131:Trace Elements / Q000097:blood*
chemical_list: D014131:Trace Elements
keywords: Goitrous children; Iodine; Selenium; Trace elements; Zinc