title: Lineage, fate, and fate potential of NG2-glia.
abstract: NG2 cells represent a fourth major glial cell population in the mammalian central nervous system (CNS). They arise from discrete germinal zones in mid-gestation embryos and expand to occupy the entire CNS parenchyma. Genetic fate mapping studies have shown that oligodendrocytes and a subpopulation of ventral protoplasmic astrocytes arise from NG2 cells. This review describes recent findings on the fate and fate potential of NG2 cells under physiological and pathological conditions. We discuss age-dependent changes in the fate and fate potential of NG2 cells and possible mechanisms that could be involved in restricting their oligodendrocyte differentiation or fate plasticity. This article is part of a Special Issue entitled SI:NG2-glia(Invited only).
authors: Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06268, USA. Electronic address: akiko.nishiyama@uconn.edu.
authors: Akiko
authors: A
authors: Nishiyama
authors: Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06268, USA.
authors: Linda
authors: L
authors: Boshans
authors: Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06268, USA.
authors: Christopher M
authors: CM
authors: Goncalves
authors: Biotechnology and Bioservices Center, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06268, USA.
authors: Jill
authors: J
authors: Wegrzyn
authors: Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06268, USA.
authors: Kiran D
authors: KD
authors: Patel
mesh_terms: D000818:Animals; D000941:Antigens / Q000378:metabolism*; D019070:Cell Lineage / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development / Q000502:physiology; D006801:Humans; D009457:Neuroglia / Q000166:cytology / Q000502:physiology*; D011509:Proteoglycans / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D000099216:Chondroitin Sulfate Proteoglycan 4
chemical_list: D000941:Antigens; D011509:Proteoglycans; D000099216:Chondroitin Sulfate Proteoglycan 4
keywords: Cell fate; Lineage; Myelin; NG2; Oligodendrocyte; Polydendrocyte