title: Contribution of chemotherapy mobilization to disease control in multiple myeloma treated with autologous hematopoietic cell transplantation.
abstract: In patients with multiple myeloma (MM) undergoing autologous hematopoietic cell transplantation (auto-HCT), peripheral blood progenitor cells may be collected following mobilization with growth factor alone (GF) or cytotoxic chemotherapy plus GF (CC+GF). It is uncertain whether the method of mobilization affects post-transplant outcomes. We compared these mobilization strategies in a retrospective analysis of 968 patients with MM from the Center for International Blood and Marrow Transplant Research database who received an auto-HCT in the US and Canada between 2007 and 2012. The kinetics of neutrophil engraftment (⩾0.5 × 10(9)/L) was similar between groups (13 vs 13 days, P=0.69) while platelet engraftment (⩾20 × 10(9)/L) was slightly faster with CC+GF (19 vs 18 days, P=0.006). Adjusted 3-year PFS was 43% (95% confidence interval (CI) 38-48) in GF and 40% (95% CI 35-45) in CC+GF, P=0.33. Adjusted 3-year OS was 82% (95% CI 78-86) vs 80% (95% CI 75-84), P=0.43 and adjusted 5-year OS was 62% (95% CI 54-68) vs 60% (95% CI 52-67), P=0.76, for GF and CC+GF, respectively. We conclude that MM patients undergoing auto-HCT have similar outcomes irrespective of the method of mobilization and found no evidence that the addition of chemotherapy to mobilization contributes to disease control.
authors: Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
authors: G L
authors: GL
authors: Uy
authors: Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors: L J
authors: LJ
authors: Costa
authors: Center for International Blood and Marrow Transplant Research (CIBMTR), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
authors: P N
authors: PN
authors: Hari
authors: Center for International Blood and Marrow Transplant Research (CIBMTR), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.|Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI, USA.
authors: M-J
authors: MJ
authors: Zhang
authors: Center for International Blood and Marrow Transplant Research (CIBMTR), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
authors: J-X
authors: JX
authors: Huang
authors: Hematologic Oncology Treatment Center, Dana-Farber Cancer Institute, Boston, MA, USA.
authors: K C
authors: KC
authors: Anderson
authors: The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
authors: C N
authors: CN
authors: Bredeson
authors: University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
authors: N S
authors: NS
authors: Callander
authors: Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: R F
authors: RF
authors: Cornell
authors: Servicio de Oncohematologia, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.
authors: M A D
authors: MA
authors: Perez
authors: Department of Hematology, Mayo Clinic, Rochester, MN, USA.
authors: A
authors: A
authors: Dispenzieri
authors: South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
authors: C O
authors: CO
authors: Freytes
authors: Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK.
authors: R P
authors: RP
authors: Gale
authors: Division of Hematology/Oncology, Perelman Center for Advanced Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
authors: A
authors: A
authors: Garfall
authors: Department of Hematology, Mayo Clinic, Rochester, MN, USA.
authors: M A
authors: MA
authors: Gertz
authors: Haematology Department, Royal Prince Alfred Hospital Institute of Haematology, Camperdown, New South Wales, Australia.
authors: J
authors: J
authors: Gibson
authors: Center for International Blood and Marrow Transplant Research (CIBMTR), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
authors: M
authors: M
authors: Hamadani
authors: Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH, USA.
authors: H M
authors: HM
authors: Lazarus
authors: Hematologic Oncology and Blood Disorders, Cleveland Clinic, Cleveland, OH, USA.
authors: M E
authors: ME
authors: Kalaycio
authors: Division of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
authors: R T
authors: RT
authors: Kamble
authors: Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors: M A
authors: MA
authors: Kharfan-Dabaja
authors: Department of Hematology/Oncology, City of Hope National Medical Center, Duarte, CA, USA.
authors: A Y
authors: AY
authors: Krishnan
authors: Department of Hematology, Mayo Clinic, Rochester, MN, USA.
authors: S K
authors: SK
authors: Kumar
authors: Department of Hematology, Mayo Clinic, Rochester, MN, USA.
authors: R A
authors: RA
authors: Kyle
authors: Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: H J
authors: HJ
authors: Landau
authors: Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, South Australia, Australia.
authors: C H
authors: CH
authors: Lee
authors: Hospital Universitário Clementinio Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors: A
authors: A
authors: Maiolino
authors: Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, UK.
authors: D I
authors: DI
authors: Marks
authors: Department of Medicine, New York Presbyterian Hospital at Cornell, New York, NY, USA.
authors: T M
authors: TM
authors: Mark
authors: Section of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport, Shreveport, LA, USA.
authors: R
authors: R
authors: Munker
authors: Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors: T
authors: T
authors: Nishihori
authors: Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.|Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden.
authors: R F
authors: RF
authors: Olsson
authors: Division of Hematology and Oncology, Department of Medicine, UMass Memorial Medical Center, Worcester, MA, USA.
authors: M
authors: M
authors: Ramanathan
authors: Bone Marrow Transplant Program, Loyola University Medical Center, Chicago, IL, USA.
authors: T E
authors: TE
authors: Rodriguez
authors: Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors: A A
authors: AA
authors: Saad
authors: Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: B N
authors: BN
authors: Savani
authors: Bone Marrow Transplant Program, UCLA Center for Health Sciences, Los Angeles, CA, USA.
authors: G J
authors: GJ
authors: Schiller
authors: Department of Hematology, Academische Ziekenhuis, Maastricht, The Netherlands.
authors: H C
authors: HC
authors: Schouten
authors: Cancer Transplant Institute, Virginia G. Piper Cancer Center, Scottsdale, AZ, USA.|Arizona Oncology, Scottsdale, AZ, USA.
authors: J R
authors: JR
authors: Schriber
authors: Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR, USA.
authors: E
authors: E
authors: Scott
authors: Department of Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors: S
authors: S
authors: Seo
authors: Department of Hematology/Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
authors: M
authors: M
authors: Sharma
authors: Blood and Marrow Transplantation, Division of Hematology and Oncology, University of Kansas Medical Center, Kansas City, KS, USA.
authors: S
authors: S
authors: Ganguly
authors: Division of Hematology/Oncology, Perelman Center for Advanced Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
authors: E A
authors: EA
authors: Stadtmauer
authors: Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors: J
authors: J
authors: Tay
authors: Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, South Australia, Australia.
authors: L B
authors: LB
authors: To
authors: Hackensack University Medical Center, Hackensack, NJ, USA.
authors: D H
authors: DH
authors: Vesole
authors: Division of Hematology/Oncology, Perelman Center for Advanced Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
authors: D T
authors: DT
authors: Vogl
authors: Department of Hematology/Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
authors: J L
authors: JL
authors: Wagner
authors: Seattle Cancer Care Alliance, Seattle, WA, USA.
authors: B
authors: B
authors: Wirk
authors: Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
authors: W A
authors: WA
authors: Wood
authors: Center for International Blood and Marrow Transplant Research (CIBMTR), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
authors: A
authors: A
authors: D'Souza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D064592:Autografts; D018572:Disease-Free Survival; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000628:therapy*; D010976:Platelet Count; D011446:Prospective Studies; D020127:Recovery of Function; D015996:Survival Rate