title: Pseudotannins self-assembled into antioxidant complexes.
abstract: Natural tannins are attractive as building blocks for biomaterials due to their antioxidant properties and ability to form interpolymer complexes (IPCs) with other macromolecules. One of the major challenges to tannin usage in biomedical applications is their instability at physiological conditions and a lack of control over the purity and reactivity. Herein, we report the synthesis and characterization of tannin-like polymers with controlled architecture, reactivity, and size. These pseudotannins were synthesized by substituting linear dextran chains with gallic, resorcylic, and protocatechuic pendant groups to mimic the structure of natural hydrolysable tannins. We demonstrate that these novel materials can self-assemble to form reductive and colloidally stable nanoscale and microscale particles. Specifically, the synthesis, turbidity, particle size, antioxidant power, and cell uptake of IPCs derived from pseudotannins and poly(ethylene glycol) was evaluated.
authors: Department of Bioengineering, Temple University, 1947 N 12th Street, Philadelphia, PA, USA. ozf@temple.edu.
authors: H A
authors: HA
authors: Cheng
authors: C T
authors: CT
authors: Drinnan
authors: N
authors: N
authors: Pleshko
authors: O Z
authors: OZ
authors: Fisher
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D000067493:Dynamic Light Scattering; D006801:Humans; D018613:Microscopy, Confocal; D008982:Molybdenum / Q000737:chemistry; D009391:Nephelometry and Turbidimetry; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013634:Tannins / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D017973:Tungsten Compounds / Q000737:chemistry
chemical_list: D000975:Antioxidants; C029556:Folin's phenol reagent; D013634:Tannins; D017973:Tungsten Compounds; D011092:Polyethylene Glycols; D008982:Molybdenum