title: A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa.
abstract: A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A-C (2-4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1-3 exhibited protective effects against DOX-induced cardiotoxicity.
authors: School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China. limeng31716@163.com.|Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. limeng31716@163.com.
authors: Meng
authors: M
authors: Li
authors: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. wxl_@163.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. wxl_@163.com.
authors: Xiaolan
authors: X
authors: Wang
authors: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. zhengxk.2006@163.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. zhengxk.2006@163.com.
authors: Xiaoke
authors: X
authors: Zheng
authors: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. 15238397097@163.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. 15238397097@163.com.
authors: Jianchao
authors: J
authors: Wang
authors: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. 18236159652@163.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. 18236159652@163.com.
authors: Wei
authors: W
authors: Zhao
authors: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. songky5901@163.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. songky5901@163.com.
authors: Kai
authors: K
authors: Song
authors: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. zhengxk.2006@163.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. zhengxk.2006@163.com.
authors: Xuan
authors: X
authors: Zhao
authors: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. zyl2013hnzy@163.com.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. zyl2013hnzy@163.com.
authors: Yanli
authors: Y
authors: Zhang
authors: School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China. hxkuang@hotmail.com.
authors: Haixue
authors: H
authors: Kuang
authors: Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China. fwsh@hactcm.edu.cn.|School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. fwsh@hactcm.edu.cn.
authors: Weisheng
authors: W
authors: Feng
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D002460:Cell Line; D004317:Doxorubicin / Q000494:pharmacology / Q000633:toxicity; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D032383:Myocytes, Cardiac / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry*; D032267:Rehmannia / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D006027:Glycosides; D017705:Lignans; D004317:Doxorubicin
keywords: Rehmannia glutinosa; ionone glycoside; rhemaneolignans; the protective effects of cardiomyocytes