title: Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients.
abstract: OBJECTIVE
  Diabetes is a common diseases and a major problem worldwide. Diabetic osteopathy might be elevated in diabetic patients and is usually caused by bone fracture. Several diabetes medications, such as thiazolidinediones (TZDs), could lead to increased risks of fracture.
  
  
  METHODS
  We used the nationwide database to identified 32466 patients who had developed type 2 diabetes from 2000 to 2010 as the diabetic cohort and, from that group, we selected 3427 diabetic patients who had developed bone fracture to survey the possible risk factors, includng commonly used diabetes medication.
  
  
  RESULTS
  We found that TZDs might present increased risks for fracture in patients who used it for an extended period (7 to 730 days before the index date), especially in female patients younger than 64 years old, for whom the risk was elevated from a 1.74- to a 2.58-fold odds ratio.
  
  
  CONCLUSIONS
  We recommend that clinics follow up with non-osteoporotic female patients younger than 64 years old who are using TZDs, to avoid the associated risks of fracture.
authors: School of Public Health, Chung Shan Medical University, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Metabolism & Endocrinology, Changhua Christian Hospital, Changhua, Taiwan; Division of Metabolism & Endocrinology, Nantou Christian Hospital, Nantou, Taiwan.
authors: Hsin-Hung
authors: HH
authors: Chen
authors: Division of Critical Care Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; Changhua Christian medical foundation, Yuanlin Christian Hospital, Changhua, Taiwan.
authors: Ming-Hwarng
authors: MH
authors: Horng
authors: Department of Healthcare Administration, Asia University, Taichung, Taiwan.
authors: Su-Yin
authors: SY
authors: Yeh
authors: School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Family Medicine, Changhua Christian Hospital, Changhua, Taiwan.
authors: I-Ching
authors: IC
authors: Lin
authors: School of Public Health, Chung Shan Medical University, Taichung, Taiwan; Education and Research on Geriatrics and Gerontology, Chung Shan Medical University, Taichung, Taiwan.
authors: Chih-Jung
authors: CJ
authors: Yeh
authors: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan.
authors: Chih-Hsin
authors: CH
authors: Muo
authors: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
authors: Fung-Chang
authors: FC
authors: Sung
authors: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
authors: Chia-Hung
authors: CH
authors: Kao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D016208:Databases, Factual; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011159:Population Surveillance; D012737:Sex Factors; D045162:Thiazolidinediones / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione