title: Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide-alkyne cycloadditions.
abstract: The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide-alkyne cycloadditions is presented. Selectivity factors (s) up to 22.1 ± 0.5 are reported. Enantioenriched alkynes and triazoles were obtained in ≥80% enantiomeric excess (e.e.).
authors: School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, UK. j.s.fossey@bham.ac.uk.
authors: William D G
authors: WD
authors: Brittain
authors: Department of Chemistry, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK. b.r.buckley@lboro.ac.uk.
authors: Benjamin R
authors: BR
authors: Buckley
authors: School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, UK. j.s.fossey@bham.ac.uk.
authors: John S
authors: JS
authors: Fossey
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D061565:Cycloaddition Reaction; D007211:Indoles / Q000737:chemistry*; D007700:Kinetics; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001386:Azides; D007211:Indoles; D003300:Copper