title: KPC and VIM producing Enterobacter cloacae strain from a hospital in northeastern Venezuela.
abstract: An 83-year-old male patient is admitted to the central hospital in Cumana, Venezuela with severe urinary infection, history of hospitalizaions and prolonged antimicrobial treatments. A strain of Enterobacter cloacae was isolated showing resistance to multiple types of antibiotics (only sensitive to gentamicin), with phenotype of serine- and metallo-carbapenemases. Both, bla(VIM-2) and bla(KPC) genes were detected in the isolate. This is the first report of an Enterobacteriaceae species producing both KPC carbapenemase and VIM metallo carbapenemase in Venezuela. This finding has a great clinical and epidemiological impact in the region, because of the feasibility of transferring these genes, through mobile elements to other strains of Enterobacter and to other infection-causing species of bacteria.
authors: Dianny
authors: D
authors: Martínez
authors: Daniel
authors: D
authors: Marcano
authors: Hectorina
authors: H
authors: Rodulfo
authors: Nurys
authors: N
authors: Salgado
authors: Nirvia
authors: N
authors: Cuaical
authors: Lucy
authors: L
authors: Rodriguez
authors: Luisa
authors: L
authors: Caña
authors: Belkis
authors: B
authors: Medina
authors: Militza
authors: M
authors: Guzman
authors: Marcos
authors: M
authors: De Donato
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D016972:Enterobacter cloacae / Q000235:genetics / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000235:genetics* / Q000382:microbiology; D006801:Humans; D008297:Male; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology; D014687:Venezuela; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases; C498060:beta-lactamase KPC-3, Enterobacter cloacae