title: Effects of Acetylsalicylic Acid Usage on Inflammatory and Oxidative Stress Markers in Hemodialysis Patients.
abstract: The aims of this study were to determine the effects of acetylsalicylic acid (ASA) on inflammation and oxidative stress markers in hemodialysis (HD) patients and to examine the associations between these markers and the sociodemographic and clinical characteristics of participants. The study included 36 subjects who used 300 mg of ASA for 60 days. Inflammation and oxidative stress were assessed based on levels of biochemical markers. ASA usage promoted a decrease in high-sensitivity C-reactive protein (p = 0.01). The level of hydrogen peroxide increased after 30 days of use of ASA and subsequently decreased (p = 0.01). Reduced glutathione reduced at the end of the study (p < 0.01); the malondialdehyde level did not change and the levels of vitamins A and E were inverse to drug use (p = 0.01). ASA usage promoted reduced levels of inflammation, increased production of markers of oxidative stress, and reduced antioxidant defense.
authors: Division of Nephrology, Ribeirão Preto Medical School of University of São Paulo, Ribeirão Preto, SP, Brazil. fa_nutricao@hotmail.com.
authors: Fabíola Pansani
authors: FP
authors: Maniglia
authors: Division of Nephrology, Ribeirão Preto Medical School of University of São Paulo, Ribeirão Preto, SP, Brazil.
authors: José Abrão Cardeal
authors: JAC
authors: da Costa
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001241:Aspirin / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D006435:Renal Dialysis; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde; D002097:C-Reactive Protein; D006861:Hydrogen Peroxide; D005978:Glutathione; D001241:Aspirin
keywords: acetylsalicylic acid; antioxidant vitamins; hemodialysis; inflammation; oxidative stress