title: A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification.
abstract: Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. In this review, we propose a mechanism that controls GSCs and their cell fate through selective activation, repression and mobilization of the specific mRNAs. This mechanism is acutely controlled by known signal transduction pathways (e.g., Notch signaling and Ras-ERK MAPK signaling pathways) and P granule (analogous to mammalian germ granule)-associated mRNA regulators (FBF-1, FBF-2, GLD-1, GLD-2, GLD-3, RNP-8 and IFE-1). Importantly, all regulators are highly conserved in many multi-cellular animals. Therefore, GSCs from a simple animal may provide broad insight into vertebrate stem cells (e.g., hematopoietic stem cells) and their cell fate specification. [BMB Reports 2016; 49(2): 93-98].
authors: Department of Medicine, Hematology/Oncology Division, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA; Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
authors: Myon-Hee
authors: MH
authors: Lee
authors: Department of Medicine, Hematology/Oncology Division, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
authors: Srivalli Swathi
authors: SS
authors: Mamillapalli
authors: Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
authors: Brett D
authors: BD
authors: Keiper
authors: Department of Oriental Pharmacy, College of Pharmacy, Woosuk University, Jeonju 55338, Korea.
authors: Dong Seok
authors: DS
authors: Cha
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000235:genetics*; D005854:Germ Cells / Q000166:cytology* / Q000378:metabolism; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D015533:Transcriptional Activation / Q000235:genetics
chemical_list: D012333:RNA, Messenger