title: Inhibition of MiR-155 suppresses cell migration in nasopharyngeal carcinoma through targeting ZDHHC2.
abstract: Overexpression of miR-155 in nasopharygeal carcinoma (NPC) is partly driven by Epstein-Bar virus infection. However the role of miR-155 in NPC oncogenesis is unclear. This study showed that miR-155 inhibitor could inhibit the cell migration in NPC cell lines. ZDHHC2 was identified as a direct target of miR-155 and downregulation of ZDHHC2 prompted cell migration in NPC. Furthermore, reduced ZDHHC2 expression was associated significantly with metastasis and poor survival of NPC patients. Collectively, inhibition of miR-155 suppresses cell migration in NPC through targeting ZDHHC2. The potential of miR-155 and ZDHHC2 as therapeutic targets in NPC should be further investigated.
authors: Sate key Laboratory of Oncology in South China, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou, P.R. China.
authors: Yuan-Xue
authors: YX
authors: Jiang
authors: Sate Key Laboratory of Oncology in South China, Department of Pathology, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou, P.R. China.
authors: Zi-Ming
authors: ZM
authors: Du
authors: Sate Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou, P.R. China.
authors: Lin
authors: L
authors: Jiao
authors: Sate Key Laboratory of Oncology in South China, Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou, P.R. China.
authors: Qiong
authors: Q
authors: Shao
authors: Sate Key Laboratory of Oncology in South China, Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou, P.R. China.
authors: Sha
authors: S
authors: Fu
authors: Sate Key Laboratory of Oncology in South China, Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou, P.R. China.
authors: Jian-Yong
authors: JY
authors: Shao
authors: Sate Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou, P.R. China.
authors: Xiao-Feng
authors: XF
authors: Zhu
authors: Department of Microbiolgy, Tumor and Cell Biology, Karolinska Institutet Stockholm, Sweden.
authors: Ingemar
authors: I
authors: Ernberg
authors: Sate key Laboratory of Oncology in South China, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine Guangzhou, P.R. China.
authors: Yu-Hong
authors: YH
authors: Li
keywords: Nasopharyngeal carcinoma; ZDHHC2; cell migration; miR-155