title: N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin.
abstract: In eukaryotes, cytosolic monothiol glutaredoxins are proteins implicated in intracellular iron trafficking and sensing via their bound [2Fe-2S] clusters. We define a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved in the biogenesis of cytosolic and nuclear Fe-S proteins. Specific protein recognition between the N-terminal domains of the two proteins is the mandatory requisite to promote the [2Fe-2S] cluster transfer from GRX3 to anamorsin.
authors: Magnetic Resonance Center CERM, University of Florence, Florence, Italy.|Department of Chemistry, University of Florence, Florence, Italy.
authors: Lucia
authors: L
authors: Banci
authors: Magnetic Resonance Center CERM, University of Florence, Florence, Italy.|Department of Chemistry, University of Florence, Florence, Italy.
authors: Simone
authors: S
authors: Ciofi-Baffoni
authors: Magnetic Resonance Center CERM, University of Florence, Florence, Italy.
authors: Karolina
authors: K
authors: Gajda
authors: Magnetic Resonance Center CERM, University of Florence, Florence, Italy.|Department of Chemistry, University of Florence, Florence, Italy.
authors: Riccardo
authors: R
authors: Muzzioli
authors: Magnetic Resonance Center CERM, University of Florence, Florence, Italy.
authors: Riccardo
authors: R
authors: Peruzzini
authors: Magnetic Resonance Center CERM, University of Florence, Florence, Italy.
authors: Julia
authors: J
authors: Winkelmann
mesh_terms: D001059:Apoproteins / Q000737:chemistry / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D062105:Molecular Docking Simulation; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D021381:Protein Transport
chemical_list: D001059:Apoproteins; C489114:CIAPIN1 protein, human; D002352:Carrier Proteins; C404105:GLRX3 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D007506:Iron-Sulfur Proteins; D007501:Iron