title: Serum markers of CYFRA 21-1 and C-reactive proteins in oral squamous cell carcinoma.
abstract: BACKGROUND
  CYFRA 21-1 (cytokeratin 19 fragment) and C-reactive proteins (CRP) were separately reported to be associated with prognosis of head and neck squamous cell carcinoma. The combined roles of CYFRA 21-1 and CRP levels were rarely investigated in oral squamous cell carcinoma (OSCC). The purpose of the present study was to analyze the relationship between preoperative levels of both CYFRA 21-1 and CRP, with clinicopathological factors and prognosis in OSCC patients.
  
  
  METHODS
  A retrospective study was performed on 130 OSCC patients between December 2010 and June 2013. Their serum CYFRA 21-1 and CRP levels were measured preoperatively.
  
  
  RESULTS
  CYFRA 21-1 level of ≥3.3 ng/mL and CRP level of ≥5.0 mg/L were significantly associated with pathological tumor status (P<0.001), tumor depth (>10 vs. ≤10 mm, P=0.001), bone invasion (P=0.001), skin invasion (P=0.006), pathologic nodal metastasis (P=0.012), and disease-free survival (P=0.009). Higher CYPFRA 21-1 and CRP levels were also associated with higher risks of distant metastasis (log-rank test, P=0.013, (HR [95% CI]) 1.692 [1.097-2.414]).
  
  
  CONCLUSIONS
  Preoperative CYFRA 21-1 and CRP levels are probable candidates as biomarkers for risk stratification in OSCC.
authors: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Shin Street, Kwei-Shan, Linkou, Taoyuan, 333, Taiwan, Republic of China. d8324@cgmh.org.tw.
authors: Yin-Ping
authors: YP
authors: Hsu
authors: Department of Medical Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, Republic of China. wisdom5000@gmail.com.
authors: Chia-Hsun
authors: CH
authors: Hsieh
authors: Department of Public Health, Chang Gung University, Taoyuan, Taiwan, Republic of China. kathy.htchien@gmail.com.
authors: Hui-Tzu
authors: HT
authors: Chien
authors: Department of Public Health, Chang Gung University, Taoyuan, Taiwan, Republic of China. urinebeario@hotmail.com.
authors: Chi-Hsiung
authors: CH
authors: Lai
authors: Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Taoyuan, Taiwan, Republic of China. nightman@ms8.hinet.net.
authors: Chung-Kan
authors: CK
authors: Tsao
authors: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Shin Street, Kwei-Shan, Linkou, Taoyuan, 333, Taiwan, Republic of China. liaoct@adm.cgmh.org.tw.
authors: Chun-Ta
authors: CT
authors: Liao
authors: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Shin Street, Kwei-Shan, Linkou, Taoyuan, 333, Taiwan, Republic of China. handneck@gmail.com.
authors: Chung-Jan
authors: CJ
authors: Kang
authors: Department of Medical Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, Republic of China. whm526@adm.cgmh.org.tw.
authors: Hung-Ming
authors: HM
authors: Wang
authors: Department of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, Republic of China. cgmhnog@gmail.com.
authors: Joseph Tung-Chieh
authors: JT
authors: Chang
authors: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Shin Street, Kwei-Shan, Linkou, Taoyuan, 333, Taiwan, Republic of China. bigmac@adm.cgmh.org.tw.
authors: Shiang-Fu
authors: SF
authors: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000401:mortality / Q000556:secondary; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053539:Keratin-19 / Q000097:blood*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053539:Keratin-19; C102012:antigen CYFRA21.1; D002097:C-Reactive Protein