title: Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [(45)Ti](salan)Ti(dipic).
abstract: We present a novel solid-phase based (45)Ti radiolabeling methodology and the implementation of (45)Ti-PET in titanium-based antineoplastics using the showcase compound [(45)Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.
authors: Hevesy Laboratory, Center for Nuclear Technologies at the Technical University of Denmark , Frederiksborgvej 399, 4000 Roskilde, Denmark.
authors: Gregory W
authors: GW
authors: Severin
authors: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen , Blegdamsvej 3, 2200 Copenhagen, Denmark.|Minerva Imaging , Ole Maaløes Vej 3, 2200 Copenhagen, Denmark.
authors: Carsten H
authors: CH
authors: Nielsen
authors: Hevesy Laboratory, Center for Nuclear Technologies at the Technical University of Denmark , Frederiksborgvej 399, 4000 Roskilde, Denmark.
authors: Andreas I
authors: AI
authors: Jensen
authors: Hevesy Laboratory, Center for Nuclear Technologies at the Technical University of Denmark , Frederiksborgvej 399, 4000 Roskilde, Denmark.
authors: Jesper
authors: J
authors: Fonslet
authors: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen , Blegdamsvej 3, 2200 Copenhagen, Denmark.
authors: Andreas
authors: A
authors: Kjær
authors: Hevesy Laboratory, Center for Nuclear Technologies at the Technical University of Denmark , Frederiksborgvej 399, 4000 Roskilde, Denmark.
authors: Fedor
authors: F
authors: Zhuravlev
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D019073:HT29 Cells; D006801:Humans; D008819:Mice, Nude; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D060327:Solid-Phase Synthesis Techniques; D014018:Tissue Distribution; D014025:Titanium; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D019275:Radiopharmaceuticals; D014025:Titanium