title: Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children.
abstract: Irisin has been suggested to protect against overweight. There are no previous data on the association of plasma fatty acid (FA) composition with plasma irisin.
  
  
  
  We studied the association of FA composition with plasma irisin in normal weight and overweight/obese children.
  
  
  
  This cross-sectional study included pre-pubertal children (388 normal weight children and 55 overweight/obese children); 6-9 years of age, taking part in the Physical Activity and Nutrition in Children Study. After an overnight fast, we measured plasma FA composition by gas chromatography and plasma irisin levels by enzyme-linked immunosorbent assay.
  
  
  
  Higher proportion of total monounsaturated fatty acids in plasma cholesteryl esters (CEs) (β = 0.139, P = 0.003) and phospholipids (PLs) (β = 0.147, P = 0.002) and lower proportion of total polyunsaturated fatty acids in plasma CE (β = -0.130, P = 0.006) and PL (β = -0.165, P < 0.001) were associated with higher plasma irisin level in the whole study group. The association of plasma FA composition with plasma irisin level was stronger among overweight/obese children compared to normal weight children. Higher proportion of γ-linolenic acid (β = 0.324, P = 0.017) and lower proportion of linoleic acid (β = -0.397, P = 0.005) in plasma CE were related to higher plasma irisin level among overweight/obese children, indicating the direct association of estimated D6D activity in plasma CE (β = 0.343, P = 0.011) with plasma irisin. Furthermore, higher proportion of oleic acid in plasma CE (β = 0.345, P = 0.012) and PL (β = 0.292, P = 0.033) and higher proportion of adrenic acid (β = 0.366, P = 0.008) and docosapentaenoic acid (β = 0.351, P = 0.010) in plasma PL were associated with higher plasma irisin level among overweight/obese children.
  
  
  
  Metabolically unfavourable plasma FA profile was associated with higher plasma irisin level especially in overweight/obese children, suggesting that excess body fat might modulate these relationships.
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
authors: A
authors: A
authors: Viitasalo
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
authors: J
authors: J
authors: Ågren
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.|Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
authors: T
authors: T
authors: Venäläinen
authors: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.|Department of Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland.
authors: J
authors: J
authors: Pihlajamäki
authors: Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
authors: J
authors: J
authors: Jääskeläinen
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
authors: A
authors: A
authors: Korkmaz
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
authors: M
authors: M
authors: Atalay
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.|Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
authors: T A
authors: TA
authors: Lakka
mesh_terms: D002648:Child; D002849:Chromatography, Gas; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005227:Fatty Acids / Q000097:blood* / Q000737:chemistry; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008297:Male; D050177:Overweight / Q000097:blood*; D063766:Pediatric Obesity / Q000097:blood*; D012307:Risk Factors
chemical_list: C577593:FNDC5 protein, human; D005227:Fatty Acids; D005353:Fibronectins
keywords: Children; fatty acid; irisin; overweight