title: Extracellular Hydrolysis of Adenine Nucleotides and Nucleoside Adenosine is Higher in Patients with ST Elevation than Non-ST Elevation in Acute Myocardial Infarction.
abstract: BACKGROUND
  The hydrolysis of adenine nucleotide linked to the membrane of the platelets is changed in acute myocardial infarction (AMI) probably due to a greater arterial blockage and cell damage in patients with ST elevation (STEMI) than in those without ST segment elevation (NSTEM).
  
  
  METHODS
  This study aimed to compare the extracellular hydrolysis of adenine nucleotides on the platelet surface of STEMI and NSTEMI patients. This study was carried out with 50 patients with AMI (STEMI and NSTEMI). The extracellular hydrolysis of adenine nucleotides and nucleoside adenosine as well as the expression of NTPDase were verified in platelets.
  
  
  RESULTS
  The results demonstrated that STEMI patients had significantly higher extracellular hydrolysis of adenine nucleotides (p < 0.001), ADA (adenosine deaminase) activity (p < 0.05), as well as troponin levels (p < 0.0001) when compared to NSTEMI patients.
  
  
  CONCLUSIONS
  Findings suggest that the extracellular hydrolysis of adenine nucleotides and increase in the ADA activity are higher in patients with STEMI than in those with NSTEMI probably because there was a blockage in this major arterial with a large area of damaged tissue.
authors: Marinês Calegari
authors: MC
authors: Lavall
authors: Margarete Dulce
authors: MD
authors: Bagatini
authors: Gustavo Roberto
authors: GR
authors: Thomé
authors: Gabriela
authors: G
authors: Bonfanti
authors: Maria Beatriz
authors: MB
authors: Moretto
authors: Liliane Zimmermann
authors: LZ
authors: De Oliveira
authors: Natália
authors: N
authors: Brucker
authors: Vera Maria
authors: VM
authors: Morsch
authors: Maria Rosa Chitolina
authors: MR
authors: Schetinger
mesh_terms: D000227:Adenine Nucleotides / Q000097:blood*; D000241:Adenosine / Q000097:blood*; D000243:Adenosine Deaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006801:Humans; D006868:Hydrolysis; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000201:enzymology; D014336:Troponin / Q000097:blood; D015854:Up-Regulation
chemical_list: D000227:Adenine Nucleotides; D015415:Biomarkers; D014336:Troponin; C548482:ADA protein, human; D000243:Adenosine Deaminase; D000241:Adenosine