title: Omalizumab therapy for children and adolescents with severe allergic asthma.
abstract: Omalizumab, a therapeutic humanized monoclonal antibody specific for human IgE, was introduced in clinical practice more than a decade ago as an add-on therapy for moderate-to-severe allergic asthma in patients aged ≥12 years. Omalizumab has been demonstrated to be effective in adults with uncontrolled persistent asthma, with an excellent safety profile. In simple terms, omalizumab works by inhibiting the allergic cascade, that is, by neutralization of the circulating free IgE. This leads to reduction in the quantity of cell-bound IgE, downregulation of high-affinity IgE receptors, and, eventually, prevention of mediator release from effector cells. Evidence is far less abundant on the role of omalizumab in pediatric asthma. Although efficacy and safety of omalizumab in children and adolescents with uncontrolled, persistent allergic asthma has been recognized as well, further studies are needed to clarify a number of open questions in this specific patient population.
authors: a Division of Internal Medicine, Allergy and Clinical Immunology, Department of Medical and Surgical Sciences, Second University of Naples School of Medicine, Piazza Miraglia 3, 80138 Naples, Italy.
authors: Ciro
authors: C
authors: Romano
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D002648:Child; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D000069444:Omalizumab / Q000276:immunology / Q000627:therapeutic use*; D017455:Receptors, IgE / Q000276:immunology*
chemical_list: D017455:Receptors, IgE; D000069444:Omalizumab; D007073:Immunoglobulin E
keywords: adolescents; anti-IgE; asthma; children; omalizumab