title: Anti-neuroinflammatory sesquiterpenes from Chinese eaglewood.
abstract: Nine new sesquiterpenes (1-9), together with seventeen known ones (10-26), were isolated from Chinese eaglewood. Their structures were established by extensive spectroscopic analysis, and the absolute configuration of 6 was determined by the modified Mosher's method. Compounds 7, 10, 14, 15, and 21 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 values in the range 7.1-53.8 μM.
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People's Republic of China.
authors: Hui-Xia
authors: HX
authors: Huo
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors: Zhi-Xiang
authors: ZX
authors: Zhu
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People's Republic of China.
authors: Dao-Ran
authors: DR
authors: Pang
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People's Republic of China.
authors: Yue-Ting
authors: YT
authors: Li
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People's Republic of China.
authors: Zheng
authors: Z
authors: Huang
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors: She-Po
authors: SP
authors: Shi
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors: Jiao
authors: J
authors: Zheng
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors: Qian
authors: Q
authors: Zhang
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors: Yun-Fang
authors: YF
authors: Zhao
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
authors: Peng-Fei
authors: PF
authors: Tu
authors: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address: drlj666@163.com.
authors: Jun
authors: J
authors: Li
mesh_terms: D000818:Animals; D002460:Cell Line; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D051379:Mice; D017628:Microglia / Q000187:drug effects*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D029645:Thymelaeaceae / Q000737:chemistry*; D014934:Wood / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D009569:Nitric Oxide
keywords: Anti-neuroinflammatory activity; Aquilaria sinensis; Chinese eaglewood; Sesquiterpene; Thymelaeaceae