title: Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia.
abstract: A retrospective cohort study was conducted including 3688 patients age 60 years or older without dementia enrolled in a depression screening study in primary care clinics. Information on antidepressant use and incident dementia during follow-up was retrieved from electronic medical records. The Cox proportional hazard models were used to compare the risk for incident dementia among 5 participant groups: selective serotonin re-uptake inhibitors (SSRI) only, non-SSRI only (non-SSRI), mixed group of SSRI and non-SSRI, not on antidepressants but depressed, and not on antidepressants and not depressed. SSRI and non-SSRI users had significantly higher dementia risk than the nondepressed nonusers (hazard ratio [HR]=1.83, P=0.0025 for SSRI users and HR=1.50, P=0.004 for non-SSRI users). In addition, SSRIs users had significantly higher dementia risk than non-users with severe depression (HR=2.26, P=0.0005). Future research is needed to confirm our results in other populations and to explore potential mechanism underlying the observed association.
authors: Departments of *Biostatistics§Psychiatry#Medicine, Indiana University School of Medicine†Richard M. Fairbank School of Public Health, Indiana University∥Regenstrief Institute Inc.‡Indiana University Center for Aging Research, Indianapolis¶Department of Pharmacy Practice, Purdue University School of Pharmacy, West Lafayette, IN.
authors: Chenkun
authors: C
authors: Wang
authors: Sujuan
authors: S
authors: Gao
authors: Hugh C
authors: HC
authors: Hendrie
authors: Joe
authors: J
authors: Kesterson
authors: Noll L
authors: NL
authors: Campbell
authors: Anantha
authors: A
authors: Shekhar
authors: Christopher M
authors: CM
authors: Callahan
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003704:Dementia / Q000453:epidemiology*; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors