title: Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization.
abstract: Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success.
authors: Surfaces, Products and Textile Processes Research Group, Textile and Paper Engineering Dept., Technical University of Catalonia (UPC), C/ Colom, 1, 08222, Terrassa, Spain; Biomaterials, Biomechanics and Tissue Engineering Group, Materials Science and Metallurgy Dept., UPC, Av. Diagonal 647, 08028, Barcelona, Spain.
authors: C
authors: C
authors: Labay
authors: Surfaces, Products and Textile Processes Research Group, Textile and Paper Engineering Dept., Technical University of Catalonia (UPC), C/ Colom, 1, 08222, Terrassa, Spain.
authors: J M
authors: JM
authors: Canal
authors: Department F4, Jozef Stefan Institute, Jamova cesta 39, SI-1000, Ljubljana, Slovenia.
authors: M
authors: M
authors: Modic
authors: Department F4, Jozef Stefan Institute, Jamova cesta 39, SI-1000, Ljubljana, Slovenia.
authors: U
authors: U
authors: Cvelbar
authors: Grup de Recerca en Cirurgia General - VHIR, Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron, 119-129, 08035, Spain.
authors: M
authors: M
authors: Quiles
authors: Grup de Recerca en Cirurgia General - VHIR, Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron, 119-129, 08035, Spain.
authors: M
authors: M
authors: Armengol
authors: Grup de Recerca en Cirurgia General - VHIR, Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron, 119-129, 08035, Spain.
authors: M A
authors: MA
authors: Arbos
authors: Biomaterials, Biomechanics and Tissue Engineering Group, Materials Science and Metallurgy Dept., UPC, Av. Diagonal 647, 08028, Barcelona, Spain.
authors: F J
authors: FJ
authors: Gil
authors: Biomaterials, Biomechanics and Tissue Engineering Group, Materials Science and Metallurgy Dept., UPC, Av. Diagonal 647, 08028, Barcelona, Spain. Electronic address: cristina.canal@upc.edu.
authors: C
authors: C
authors: Canal
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002460:Cell Line; D006801:Humans; D051379:Mice; D008855:Microscopy, Electron, Scanning; D058105:Polymerization; D011126:Polypropylenes; D013499:Surface Properties; D013526:Surgical Mesh
chemical_list: D000900:Anti-Bacterial Agents; D011126:Polypropylenes
keywords: Drug delivery; Fibroblast; Plasma; Polypropylene; Surface modification; Surgical mesh