title: 124I-MIBG: a new promising positron-emitting radiopharmaceutical for the evaluation of neuroblastoma.
abstract: Neuroblastoma is the most common extra-cranial solid tumor in pediatric patients. Despite the established role of 123I-MIBG and 131I-MIBG scintigraphy in this tumor, only limited data are available regarding the use of 124I-metaiodobenzylguanidine (MIBG) positron emission tomography (PET)/computed tomography (CT). We present our preliminary experience with 124I-MIBG PET/CT: two pediatric patients affected by neuroblastoma, who underwent 124I-MIBG PET/CT for pre-therapy distribution evaluation and restaging purposes. We aimed to evaluate whether 124I-MIBG PET/CT can detect as many or more neuroblastoma lesions than 123I/131I-MIBG imaging. Our cases show promising results, although further validation and standardization of 124I-MIBG PET/CT are required.
authors: 1. Positron Emission Tomography Centre IRMET S.p.A., Euromedic Inc., Turin, Italy 2. Coordinator of PET Pediatric AIMN InterGroup, Italy 3. Associate researcher of Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy. a.cistaro@irmet.com.
authors: Angelina
authors: A
authors: Cistaro
authors: Natale
authors: N
authors: Quartuccio
authors: Federico
authors: F
authors: Caobelli
authors: Arnoldo
authors: A
authors: Piccardo
authors: Rosario
authors: R
authors: Paratore
authors: Pietro
authors: P
authors: Coppolino
authors: Alessandro
authors: A
authors: Sperandeo
authors: Gaspare
authors: G
authors: Arnone
authors: Umberto
authors: U
authors: Ficola
mesh_terms: D019797:3-Iodobenzylguanidine; D002648:Child; D004583:Electrons; D005260:Female; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D009447:Neuroblastoma / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine