title: Coronary and muscle blood flow during physical exercise in humans; heterogenic alliance.
abstract: In this review, we present the relation between power generation capabilities and pulmonary oxygen uptake during incremental cycling exercise in humans and the effect of exercise intensity on the oxygen cost of work. We also discuss the importance of oxygen delivery to the working muscles as a factor determining maximal oxygen uptake in humans. Subsequently, we outline the importance of coronary blood flow, myocardial oxygen uptake and myocardial metabolic stability for exercise tolerance. Finally, we describe mechanisms of endothelium-dependent regulation of coronary and skeletal muscle blood flow, dysregulation of which may impair exercise capacity and increase the cardiovascular risk of exercise.
authors: Department of Muscle Physiology, Chair of Physiology and Biochemistry, Faculty of Rehabilitation, University School of Physical Education, Kraków, Poland. Electronic address: jerzy.zoladz@awf.krakow.pl.
authors: Jerzy A
authors: JA
authors: Zoladz
authors: Department of Muscle Physiology, Chair of Physiology and Biochemistry, Faculty of Rehabilitation, University School of Physical Education, Kraków, Poland.
authors: Joanna
authors: J
authors: Majerczak
authors: Department of Muscle Physiology, Chair of Physiology and Biochemistry, Faculty of Rehabilitation, University School of Physical Education, Kraków, Poland.
authors: Krzysztof
authors: K
authors: Duda
authors: Jagiellonian Center for Experimental Therapeutics (JCET), Jagiellonian University, Kraków, Poland; Department of Experimental Pharmacology, Chair of Pharmacology, Jagiellonian University Medical College, Kraków, Poland.
authors: Stefan
authors: S
authors: Chlopicki
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology*
keywords: Coronary blood flow; Exercise; Muscle blood flow; Muscle oxygen uptake; Myocardial oxygen uptake