title: G×E Interaction Influences Trajectories of Hand Grip Strength.
abstract: Age-related decline in grip strength predicts later life disability, frailty, lower well-being and cognitive change. While grip strength is heritable, genetic influence on change in grip strength has been relatively ignored, with non-shared environmental influence identified as the primary contributor in a single longitudinal study. The extent to which gene-environment interplay, particularly gene-environment interactions, contributes to grip trajectories has yet to be examined. We considered longitudinal grip strength measurements in seven twin studies of aging in the Interplay of Genes and Environment across Multiple Studies consortium. Growth curve parameters were estimated for same-sex pairs, aged 34-99 (N = 10,681). Fisher's test for mixture distribution of within-monozygotic twin-pair differences (N = 1724) was performed on growth curve parameters. We observed significant gene-environment interaction on grip strength trajectories. Finally, we compared the variability of within-pair differences of growth curve parameters by APOE haplotypes. Though not statistically significant, the results suggested that APOE ɛ2ɛ2/ɛ2ɛ3 haplotypes might buffer environmental influences on grip strength trajectories.
authors: The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark. ipetersen@health.sdu.dk.
authors: Inge
authors: http://orcid.org/0000-0001-8057-8336
authors: I
authors: Petersen
authors: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors: Nancy L
authors: NL
authors: Pedersen
authors: Gerontology Research Center and Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
authors: Taina
authors: T
authors: Rantanen
authors: Department of Psychiatry and Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA, USA.|Center of Excellence for Stress and Mental Health, VA San Diego Healthcare Center, La Jolla, CA, USA.
authors: William S
authors: WS
authors: Kremen
authors: Department of Psychology and Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
authors: Wendy
authors: W
authors: Johnson
authors: Department of Psychiatry and Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA, USA.
authors: Matthew S
authors: MS
authors: Panizzon
authors: The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
authors: Lene
authors: L
authors: Christiansen
authors: Department of Psychiatry and Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA, USA.
authors: Carol E
authors: CE
authors: Franz
authors: The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.|Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
authors: Matt
authors: M
authors: McGue
authors: The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.|Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.|Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
authors: Kaare
authors: K
authors: Christensen
authors: Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
authors: Nayla R
authors: NR
authors: Hamdi
authors: Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
authors: Robert F
authors: RF
authors: Krueger
authors: Department of Psychology, University of California - Riverside, Riverside, CA, USA.
authors: Chandra
authors: C
authors: Reynolds
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology; D001057:Apolipoproteins E / Q000235:genetics; D004777:Environment; D005260:Female; D059647:Gene-Environment Interaction; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D014430:Twins, Monozygotic / Q000235:genetics
chemical_list: D001057:Apolipoproteins E
keywords: APOE; Gene-environment interaction; Grip strength; Twins