title: The hematopoietic system in the context of regenerative medicine.
abstract: Hematopoietic stem cells (HSC) represent the prototype stem cell within the body. Since their discovery, HSC have been the focus of intensive research, and have proven invaluable clinically to restore hematopoiesis following inadvertent radiation exposure and following radio/chemotherapy to eliminate hematologic tumors. While they were originally discovered in the bone marrow, HSC can also be isolated from umbilical cord blood and can be "mobilized" peripheral blood, making them readily available in relatively large quantities. While their ability to repopulate the entire hematopoietic system would already guarantee HSC a valuable place in regenerative medicine, the finding that hematopoietic chimerism can induce immunological tolerance to solid organs and correct autoimmune diseases has dramatically broadened their clinical utility. The demonstration that these cells, through a variety of mechanisms, can also promote repair/regeneration of non-hematopoietic tissues as diverse as liver, heart, and brain has further increased their clinical value. The goal of this review is to provide the reader with a brief glimpse into the remarkable potential HSC possess, and to highlight their tremendous value as therapeutics in regenerative medicine.
authors: Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, 391 Technology Way, Winston-Salem, NC 27157-1083, United States. Electronic address: cporada@wakehealth.edu.
authors: Christopher D
authors: CD
authors: Porada
authors: Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, 391 Technology Way, Winston-Salem, NC 27157-1083, United States. Electronic address: aatala@wakehealth.edu.
authors: Anthony J
authors: AJ
authors: Atala
authors: Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, 391 Technology Way, Winston-Salem, NC 27157-1083, United States. Electronic address: galmeida@wakehealth.edu.
authors: Graça
authors: G
authors: Almeida-Porada
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000628:therapy; D006402:Hematologic Diseases / Q000628:therapy*; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance; D044968:Regenerative Medicine
keywords: Alternate sources of HSC; Bone marrow; HSC for repairing non-hematopoietic tissues; HSC for tolerance induction; Hematopoietic stem cell (HSC); Transplantation