title: Misassigned natural products and their revised structures.
abstract: Natural products are a major pipeline for drug development and are responsible for more than 50 % of drugs on the market. NMR is a fundamental and powerful tool for the structure determination of natural products. It is essential to provide unambiguous chemical structure information on natural products in drug development research, including the structure-activity relationship, derivatization and pharmacokinetic/pharmacodynamic studies. Advancement of NMR instruments has made it possible to deal with nanomole-scale natural products for structure elucidation, but misinterpretation of NMR spectra still occurs. We review 21 natural products with revised chemical structures and the methods used for those revisions.
authors: Cho Dang Pharm. Co. Ltd., #546, Guro5-dong, Guro-Gu, Seoul, 152-860, Korea.
authors: Hye-Dong
authors: HD
authors: Yoo
authors: Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul, 120-750, Korea.
authors: Sang-Jip
authors: SJ
authors: Nam
authors: College of Pharmacy and BK21plus R-Find Team, Dongguk University, Iisandong-gu, Seoul, Gyeonggi-do, 410-820, Korea.
authors: Young-Won
authors: YW
authors: Chin
authors: Department of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, 540-742, Korea. minsun@sunchon.ac.kr.
authors: Min-Sun
authors: MS
authors: Kim
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008517:Phytotherapy; D028321:Plant Preparations / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship
chemical_list: D028321:Plant Preparations
keywords: Drug development; NMR; Natural product; PK/PD; Structure determination; Structure–activity relationship