title: Development of a Rhodium(II)-Catalyzed Chemoselective C(sp(3) )-H Oxygenation.
abstract: We report the first example of Rh(II) -catalyzed chemoselective double C(sp(3) )-H oxygenation, which can directly transform various toluene derivatives into highly valuable aromatic aldehydes with great chemoselectivity and practicality. The critical combination of catalyst Rh(OAc)2 , oxidant Selectfluor, and solvents of TFA/TFAA promises the successful delivery of the oxidation with satisfactory yields. A possible mechanism involving a unique carbene-Rh complex is proposed, and has been supported by both experiments and theoretical calculations.
authors: MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084 (P. R. China).
authors: Yun
authors: Y
authors: Lin
authors: School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030 (P. R. China).
authors: Lei
authors: L
authors: Zhu
authors: School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030 (P. R. China). lanyu@cqu.edu.cn.
authors: Yu
authors: Y
authors: Lan
authors: MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084 (P. R. China). yrao@mail.tsinghua.edu.cn.
authors: Yu
authors: Y
authors: Rao
keywords: C(sp3)H oxygenation; carbene-Rh complex; chemoselective; oxidant; rhodium(II) catalyst