title: Insect-specific viruses and their potential impact on arbovirus transmission.
abstract: Arthropod-borne viruses (arboviruses) are the causative agents of significant morbidity and mortality among humans and animals globally. In the past few years, the widespread adoption of next generation sequencing and metagenomics has led to a new era of virus discovery, where many novel viruses have been documented, exhibiting a restricted host-range in mosquitoes. They represent a wide-range of insect-specific viruses within the families of Bunyaviridae, Flaviviridae, Mesoniviridae, Reoviridae, Rhabdoviridae, Togaviridae, and the newly recognized taxon of Negeviruses. Collectively, their discovery has opened new vistas about the extent of viral diversity and evolution, their influence on vector competence and ability of their insect hosts to transmit human pathogens (e.g. arboviruses), and their potential development as biological control agents or novel vaccine platforms.
authors: Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Center for Tropical Diseases, Institute for Human Infectious and Immunity, The University of Texas Medical Branch, Galveston, TX 77555-0609, United States. Electronic address: nivasila@utmb.edu.
authors: Nikos
authors: N
authors: Vasilakis
authors: Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Center for Tropical Diseases, Institute for Human Infectious and Immunity, The University of Texas Medical Branch, Galveston, TX 77555-0609, United States. Electronic address: rtesh@utmb.edu.
authors: Robert B
authors: RB
authors: Tesh
mesh_terms: D000818:Animals; D001102:Arbovirus Infections / Q000635:transmission* / Q000821:virology*; D001103:Arboviruses / Q000502:physiology*; D044822:Biodiversity; D009033:Culicidae / Q000821:virology; D006801:Humans; D007303:Insect Vectors / Q000821:virology*; D007304:Insect Viruses / Q000145:classification / Q000502:physiology*; D012328:RNA Viruses / Q000145:classification / Q000502:physiology