title: Innate immunological function of TH2 cells in vivo.
abstract: Type 2 helper T cells (TH2 cells) produce interleukin 13 (IL-13) when stimulated by papain or house dust mite extract (HDM) and induce eosinophilic inflammation. This innate response is dependent on IL-33 but not T cell antigen receptors (TCRs). While type 2 innate lymphoid cells (ILC2 cells) are the dominant innate producers of IL-13 in naive mice, we found here that helminth-infected mice had more TH2 cells compared to uninfected mice, and thes e cells became major mediators of innate type 2 responses. TH2 cells made important contributions to HDM-induced antigen-nonspecific eosinophilic inflammation and protected mice recovering from infection with Ascaris suum against subsequent infection with the phylogenetically distant nematode Nippostrongylus brasiliensis. Our findings reveal a previously unappreciated role for effector TH2 cells during TCR-independent innate-like immune responses.
authors: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: Liying
authors: L
authors: Guo
authors: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: Yuefeng
authors: Y
authors: Huang
authors: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: Xi
authors: X
authors: Chen
authors: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: Jane
authors: J
authors: Hu-Li
authors: United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics, and Immunology Laboratory, Beltsville, Maryland, USA.
authors: Joseph F
authors: JF
authors: Urban
authors: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: William E
authors: WE
authors: Paul
mesh_terms: D000818:Animals; D005434:Flow Cytometry; D006373:Helminthiasis / Q000276:immunology; D006376:Helminths / Q000276:immunology; D007113:Immunity, Innate; D008168:Lung / Q000166:cytology / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D016133:Polymerase Chain Reaction; D018418:Th2 Cells / Q000276:immunology*