title: The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders.
abstract: There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy. Although melatoninergic drugs have chronobiotic and antioxidant properties that positively influence circadian rhythm desynchronization and neuroprotection in neurodegenerative disorders, studies examining the use of melatonin for epilepsy's comorbid psychiatric and neurological symptomatology are still limited. Preclinical and clinical findings on the beneficial effects of the melatonin system on anxiety, depression, and epilepsy suggest that melatoninergic compounds might be effective in treating comorbid behavioral complications in epilepsy beyond regulation of a disturbed sleep-wake cycle.
authors: Institute of Neurobiology, Acad. G. Bonchev Str., Bl. 23, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria. Electronic address: janetchekalarova@gmail.com.
authors: Jana
authors: J
authors: Tchekalarova
authors: I.R.C.C.S NEUROMED, Località Camerelle, Pozzilli 86077, IS, Italy.
authors: Slavianka
authors: S
authors: Moyanova
authors: I.R.C.C.S NEUROMED, Località Camerelle, Pozzilli 86077, IS, Italy.
authors: Antonio De
authors: AD
authors: Fusco
authors: I.R.C.C.S NEUROMED, Località Camerelle, Pozzilli 86077, IS, Italy.
authors: Richard Teke
authors: RT
authors: Ngomba
mesh_terms: D000818:Animals; D015897:Comorbidity; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*; D006801:Humans; D008550:Melatonin / Q000378:metabolism*; D001523:Mental Disorders / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*
chemical_list: D008550:Melatonin
keywords: Anxiety; Chronopharmacology; Depression; Epilepsy; Melatonin