title: Overall Survival Is Impacted by Birthplace and Not Extent of Surgery in Asian Americans with Resectable Gastric Cancer.
abstract: Survival from gastric cancer in the USA still lags behind Asia. Genetic, environmental, and tumor biology differences, along with extent of surgery have been implicated. Our aim was to evaluate survival outcomes in Asian-American gastric cancer patients undergoing surgical resection by comparing place of birth and clinicopathologic characteristics (including evaluation of 15 lymph nodes).The Surveillance, Epidemiology, and End Results database was queried to identify patients treated surgically for gastric cancer with curative intent in the USA (2000-2010). US-born versus foreign-born Asian-American patients were analyzed for survival. Secondary comparison was made to non-Asian patients. Stage IV and non-surgical patients were excluded. Of 10,089 patients identified, 1467 patients were Asian: 271 were born in the USA, and 1196 were born outside the USA. Median survival was 32 months for non-Asians and 29 months for US-born Asians versus 61 months for Asian immigrants (p < 0.001). On multivariable analysis of overall survival in Asian patients, only US birthplace, older age, and higher stage yielded a significantly poorer outcome. Asian-American patients have a worse prognosis if born in the USA. Anatomic and surgical differences do not explain this disparity; environmental factors may be responsible.
authors: John Wayne Cancer Institute at Providence St. John's Health Center, Santa Monica, CA, USA.
authors: Daniel D
authors: DD
authors: Kirchoff
authors: John Wayne Cancer Institute at Providence St. John's Health Center, Santa Monica, CA, USA.
authors: Gary B
authors: GB
authors: Deutsch
authors: John Wayne Cancer Institute at Providence St. John's Health Center, Santa Monica, CA, USA.
authors: Manabu
authors: M
authors: Fujita
authors: John Wayne Cancer Institute at Providence St. John's Health Center, Santa Monica, CA, USA.
authors: David Y
authors: DY
authors: Lee
authors: University of California at Los Angeles, DOMSTAT, Los Angeles, CA, USA.
authors: Myung Shin
authors: MS
authors: Sim
authors: John Wayne Cancer Institute at Providence St. John's Health Center, Santa Monica, CA, USA.
authors: Ji Hey
authors: JH
authors: Lee
authors: John Wayne Cancer Institute at Providence St. John's Health Center, Santa Monica, CA, USA. BilchikA@jwci.org.|California Oncology Research Institute, Los Angeles, CA, USA. BilchikA@jwci.org.
authors: Anton J
authors: AJ
authors: Bilchik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001208:Asia; D001213:Asian; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018426:SEER Program; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000401:mortality* / Q000601:surgery; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Asian Americans; Ethnicity; Gastrectomy; Gastric cancer; Healthcare disparities