title: Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium.
abstract: We evaluate a new hybrid algorithm for determining nuclear morphology using angle-resolved low coherence interferometry (a/LCI) measurements in ex vivo cervical tissue. The algorithm combines Mie theory based and continuous wavelet transform inverse light scattering analysis. The hybrid algorithm was validated and compared to traditional Mie theory based analysis using an ex vivo tissue data set. The hybrid algorithm achieved 100% agreement with pathology in distinguishing dysplastic and non-dysplastic biopsy sites in the pilot study. Significantly, the new algorithm performed over four times faster than traditional Mie theory based analysis.
authors: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors: Derek
authors: D
authors: Ho
authors: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors: Tyler K
authors: TK
authors: Drake
authors: Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.
authors: Rex C
authors: RC
authors: Bentley
authors: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC 27710, USA.
authors: Fidel A
authors: FA
authors: Valea
authors: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors: Adam
authors: A
authors: Wax
keywords: (100.7410) Wavelets; (170.4440) ObGyn; (290.3200) Inverse scattering