title: Commissural functional topography of the inferior colliculus assessed in vitro.
abstract: The inferior colliculus (IC) receives ascending and descending information from several convergent neural sources. As such, exploring the neural pathways that converge in the IC is crucial to uncovering their multi-varied roles in the integration of auditory and other sensory information. Among these convergent pathways, the IC commissural connections represent an important route for the integration of bilateral information in the auditory system. Here, we describe the preparation and validation of a novel in vitro slice preparation for examining the functional topography and synaptic properties of the commissural and intrinsic projections in the IC of the mouse. This preparation, in combination with modern genetic approaches in the mouse, enables the specific examination of these pathways, which potentially can reveal cell-type specific processing channels in the auditory midbrain.
authors: Department of Comparative Biomedical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA 70803, USA. Electronic address: cclee@lsu.edu.
authors: Charles C
authors: CC
authors: Lee
authors: Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors: Yuchio
authors: Y
authors: Yanagawa
authors: Department of Comparative Biomedical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA 70803, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
authors: Kazuo
authors: K
authors: Imaizumi
mesh_terms: D000818:Animals; D001303:Auditory Cortex; D001306:Auditory Pathways; D001931:Brain Mapping; D004594:Electrophysiology; D006309:Hearing / Q000502:physiology*; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D007245:Inferior Colliculi / Q000033:anatomy & histology* / Q000502:physiology*; D007834:Lasers; D008027:Light; D008636:Mesencephalon / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000502:physiology; D018408:Patch-Clamp Techniques; D005680:gamma-Aminobutyric Acid / Q000737:chemistry
chemical_list: D005680:gamma-Aminobutyric Acid
keywords: Auditory; Commissural; Disinhibition; GABA; Inferior colliculus (IC); Inhibition