title: Loss of β-arrestin1 expression predicts unfavorable prognosis for non-small cell lung cancer patients.
abstract: We aimed to study the expression status of β-arrestin1 in non-small cell lung cancer (NSCLC) specimens and its clinicopathologic significance. The correlation between β-arrestin1 and the tumor migration biomarker E-cadherin, as well as smoking index were studied. A total of 152 patients with NSCLC who undergone surgery were enrolled. Altogether, 88 lung squamous cell lung cancer (SCC) specimens and 64 adenocarcinoma (ADC) specimens were tested for immunohistochemistry. Patients' survival was analyzed by the Kaplan-Meier method. Univariate and multivariate analyses were performed to determine independent prognostic factors. Spearman rank correlation test was used to show data associations. For SCC patients, the expression of β-arrestin1 was either lost (56 of 88, 63.6 %) or low (32 of 88, 36.4 %), which was significantly and negatively associated with E-cadherin expression (P = 0.017). The similar correlation existed between smoking index and β-arrestin1 expression (P = 0.044). For ADC patients, the deletion of β-arrestin1 expression was rare (4 of 64, 6.3 %). Loss of β-arrestin1 expression indicated poorer survival for both SCC (P = 0.026) and ADC patients (P = 0.006). β-arrestin1 expression was detected in the other ADC specimens but showed no significant correlation with survival. In SCC patients, the loss expression of β-arrestin1 was frequently observed, and β-arrestin1 expression was significantly correlated with the smoking index and E-cadherin expression, which all indicated β-arrestin1's significant clinicopathologic role. However, β-arrestin1 was expressed in most ADC patients, but its clinicopathologic role seemed to be obscure and might need further exploration.
authors: Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China.|Department of Thoracic Surgery, First Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, People's Republic of China.
authors: Honghai
authors: H
authors: Ma
authors: Institute of Oncology, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China.
authors: Liguang
authors: L
authors: Wang
authors: Institute of Oncology, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China.
authors: Tiehong
authors: T
authors: Zhang
authors: Institute of Oncology, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China.
authors: Hongchang
authors: H
authors: Shen
authors: Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China. dujiajun@sdu.edu.cn.|Institute of Oncology, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan, 250021, People's Republic of China. dujiajun@sdu.edu.cn.
authors: Jiajun
authors: J
authors: Du
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D011379:Prognosis; D012907:Smoking; D016896:Treatment Outcome; D000071559:beta-Arrestin 1 / Q000378:metabolism*
chemical_list: C000605253:ARRB1 protein, human; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; D015820:Cadherins; D000071559:beta-Arrestin 1
keywords: Lung adenocarcinoma; NSCLC; Prognosis; Squamous cell lung cancer; β-arrestin1