title: Extraintestinal Involvement of Rotavirus Infection in Children.
abstract: Rotaviruses (RVs), a member of Reoviridae family, are a major cause of severe diarrhea in children < 5 years of age worldwide, infecting mainly the gastrointestinal tract although recent findings have shown extraintestinal spread of RV infections. The RV is known to cause systemic infection in children with acute gastroenteritis (AGE). The systemic RV infection may lead to the virus reaching extraintestinal organs, therefore developing clinical symptoms. RV RNA, antigen, and infectious particles have been found in serum, cerebrospinal fluid (CSF) and extraintestinal tissues in children with AGE. According to previous studies on molecular genotyping of RV, no specific association has been yet found between antigenemia and RV G genotype. However, nucleotide changes and genotype discordance in RVs have been detected in paired stool and serum samples. In children, who show the evidence of antigenemia, RV genome is detectable in extraintestinal organs. Although, clinical significance of the laboratory findings remains to be determined.
authors: Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors: Somayeh
authors: S
authors: Jalilvand
authors: Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors: Sayed Mahdi
authors: SM
authors: Marashi
authors: Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
authors: Abbas
authors: A
authors: Tafakhori
authors: Virology Department, Pasteur Institute of Iran, Tehran, Iran. z_shoja@pasteur.ac.ir, zshoja@razi.tums.ac.ir.
authors: Zabihollah
authors: Z
authors: Shoja
mesh_terms: D000956:Antigens, Viral / Q000097:blood; D002648:Child; D005759:Gastroenteritis / Q000821:virology; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D012401:Rotavirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000821:virology*; D014766:Viremia / Q000821:virology*
chemical_list: D000956:Antigens, Viral; D012367:RNA, Viral