title: Noncoding RNAs and the control of signalling via nuclear receptor regulation in health and disease.
abstract: Nuclear receptors belong to a superfamily of proteins that play central roles in human biology, orchestrating a large variety of biological functions in both health and disease. Understanding the interactions and regulatory pathways of NRs will allow development of potential therapeutic interventions for a multitude of disease processes. Non-coding RNAs have recently been discovered to have significant interactions with NR signalling pathways via a variety of biological connections. This review summarises the known interactions between ncRNAs and the NR superfamily in health, embryogenesis and a plethora of human diseases.
authors: Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK.
authors: Paul
authors: P
authors: Cathcart
authors: School of Pharmacy, University of Reading, Whiteknights Reading Berks RG6 6AP, UK.
authors: Walter
authors: W
authors: Lucchesi
authors: Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK.
authors: Silvia
authors: S
authors: Ottaviani
authors: Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK.
authors: Alex
authors: A
authors: De Giorgio
authors: Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK.
authors: Jonathan
authors: J
authors: Krell
authors: Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK.
authors: Justin
authors: J
authors: Stebbing
authors: Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK. Electronic address: l.castellano@imperial.ac.uk.
authors: Leandro
authors: L
authors: Castellano
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018931:Antineoplastic Agents, Hormonal; D062085:RNA, Long Noncoding; D018160:Receptors, Cytoplasmic and Nuclear
keywords: Alzheimer's disease; atherosclerosis; breast cancer; gestational diabetes; lncRNA; metabolism; miRNA; neural stem cell; nuclear receptor; prostate cancer