title: Difference in blood pressure between early and late menopausal transition was significant in healthy Korean women.
abstract: BACKGROUND
  Although the prevalence of hypertension is higher in postmenopausal women than in premenopausal women, little is known about changes in blood pressure (BP) during the menopausal transition. We evaluated BP according to the menopausal transition and associated factors in healthy Korean women.
  
  
  METHODS
  This cross-sectional study involved 2037 women aged 44 to 56 years who presented at a health-screening center in Seoul, Korea, from November 2012 to March 2013. The association between BP and menopausal transition and the risk factors related to elevated BP were determined using multiple linear regression analyses. Menopausal status was divided by four groups as premenopause, early menopausal transition, late menopausal transition and postmenopause.
  
  
  RESULTS
  Both systolic and diastolic blood pressure (SBP and DBP) differed significantly according to the menopausal status. BP showed the greatest difference between early and late menopausal transition. After adjusting for variables related to hypertension, SBP (β = 2.753, p < 0.01) and DBP (β = 1.746, p = 0.02) were significantly higher in late than early menopausal transition. The prevalence of hypertension was significantly different between early and late menopausal transition (1.4 vs. 6.1 %). Waist circumference, glucose, and triglycerides were positively and significantly associated with SBP and DBP during menopause.
  
  
  CONCLUSIONS
  BP and the prevalence of hypertension were significantly associated with period between early and late menopausal transition, suggesting that changes in BP during the menopausal transition are significant. Therefore, frequent monitoring will be needed for early detection of hypertension during the menopausal transition.
authors: Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeng 2-Ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-Do, 363-951, Republic of Korea. mikyoung656@hanmail.net.
authors: Mi Kyoung
authors: MK
authors: Son
authors: Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeng 2-Ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-Do, 363-951, Republic of Korea. namkyoo.lim@gmail.com.
authors: Nam-Kyoo
authors: NK
authors: Lim
authors: Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeng 2-Ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-Do, 363-951, Republic of Korea. wnddus7361@korea.kr.
authors: Joong-Yeon
authors: JY
authors: Lim
authors: Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea. jcho@jhsph.edu.|Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. jcho@jhsph.edu.|Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. jcho@jhsph.edu.|Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. jcho@jhsph.edu.
authors: Juhee
authors: J
authors: Cho
authors: Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. yoosoo.chang@gmail.com.|Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. yoosoo.chang@gmail.com.
authors: Yoosoo
authors: Y
authors: Chang
authors: Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. sh703.yoo@gmail.com.|Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. sh703.yoo@gmail.com.
authors: Seungho
authors: S
authors: Ryu
authors: Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeng 2-Ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-Do, 363-951, Republic of Korea. myeongchan.cho@gmail.com.|Department of Internal Medicine, College of Medicine, Chungbuk National University, Chungcheongbuk-do, Republic of Korea. myeongchan.cho@gmail.com.
authors: Myeong-Chan
authors: MC
authors: Cho
authors: Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeng 2-Ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-Do, 363-951, Republic of Korea. mdhypark@gmail.com.
authors: Hyun-Young
authors: HY
authors: Park
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods; D005260:Female; D006304:Health Status; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D016014:Linear Models; D008403:Mass Screening / Q000379:methods; D008593:Menopause / Q000502:physiology*; D056910:Republic of Korea