title: Can kinomics and proteomics bridge the gap between pediatric cancers and newly designed kinase inhibitors?
abstract: The introduction of kinase inhibitors in cancer medicine has transformed chronic myeloid leukemia from a fatal disease into a leukemia subtype with a favorable prognosis by interfering with the constitutively active kinase BCR-ABL. This success story has resulted in the development of multiple kinase inhibitors. We are currently facing significant limitations in implementing these kinase inhibitors into the clinic for the treatment of pediatric malignancies. As many hallmarks of cancer are known to be regulated by intracellular protein signaling networks, we suggest focusing on these networks to improve the implementation of kinase inhibitors. This viewpoint will provide a short overview of currently used strategies for the implementation of kinase inhibitors as well as reasons why kinase inhibitors have unfortunately not yet been widely used for the treatment of pediatric cancers. We argue that by using a future personalized medicine strategy combining kinomics, proteomics, and drug screen approaches, the gap between pediatric cancers and the use of kinase inhibitors may be bridged.
authors: Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700, Groningen, The Netherlands.
authors: Naomi E
authors: NE
authors: van der Sligte
authors: Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700, Groningen, The Netherlands.
authors: Kim R
authors: KR
authors: Kampen
authors: Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700, Groningen, The Netherlands. e.s.j.m.de.bont@umcg.nl.
authors: Eveline S J M
authors: ES
authors: de Bont
mesh_terms: D002648:Child; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D057285:Precision Medicine / Q000639:trends*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011494:Protein Kinases / Q000235:genetics*; D040901:Proteomics / Q000379:methods* / Q000639:trends; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
chemical_list: D047428:Protein Kinase Inhibitors; D011494:Protein Kinases
keywords: Drug screen approaches; Kinomics; Proteomics; Study strategies; Targeted therapy