title: Photobiostimulation effect on diabetic wound at different power density of near infrared laser.
abstract: The photobiostimulation effects of near infrared 808 nm diode laser irradiance on diabetic wound were investigated. 120 rats were induced with diabetes by streptozotocin injection. Full thickness punch wounds of 6mm diameter were created on the dorsal part of the rats. All rats were randomly distributed into four groups; one group served as control group, whereas three groups were stimulated daily with unchanged energy density dose of 5 J/cm(2) with different power density, which were 0.1 W/cm(2), 0.2 W/cm(2) and 0.3 W/cm(2) with different exposure duration of 50s, 25s and 17s, respectively. Ten rats from each group were sacrificed on day 3, 6 and 9, respectively. Skin tissues were removed for histological purpose. The contraction of wound was found optimized after exposure with 0.1 W/cm(2). Based on the histological evidence, laser therapy has shown able to promote wound repair through enhanced epithelialization and collagen fiber synthesis. Generally, irradiated groups were advanced in terms of healing than non-irradiated group.
authors: Laser Center, Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia. Electronic address: piksuan88@gmail.com.
authors: PikSuan
authors: P
authors: Lau
authors: Laser Center, Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia. Electronic address: noriah.utm@gmail.com.
authors: Noriah
authors: N
authors: Bidin
authors: Laser Center, Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia.
authors: Ganesan
authors: G
authors: Krishnan
authors: Laser Center, Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia.
authors: Sana Mohammed
authors: SM
authors: AnaybBaleg
authors: Pejabat Harta Bina, Universiti Teknologi Malaysia (UTM), Skudai 81310, Johor, Malaysia.
authors: Mohamad Bin Md
authors: MB
authors: Sum
authors: Laser Center, Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia.
authors: Hazri
authors: H
authors: Bakhtiar
authors: UTM University Health Center, Skudai 81310, Johor, Malaysia.
authors: Zaleha
authors: Z
authors: Nassir
authors: Department of Biomedical Science, Faculty of Health Science, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors: Asmah
authors: A
authors: Hamid
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology*; D004817:Epidermis / Q000473:pathology / Q000528:radiation effects; D054023:Lasers, Semiconductor; D028022:Low-Level Light Therapy / Q000295:instrumentation / Q000379:methods*; D008297:Male; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014945:Wound Healing / Q000528:radiation effects*
keywords: Diabetic; Diode laser; Histological; Photobiostimulation; Therapy; Wound healing