title: Refinement of the inversion-transfer NMR experiment for faster characterization of chemical exchange.
abstract: It is shown theoretically that the inversion-transfer experiment used to estimate the value of unidirectional rate constants in chemical exchange systems can be performed faster via a reduction of the recovery delay. The chemical exchange rate constants can then be estimated accurately with a formula close to that of standard inversion transfer and easy to use, after a justified approximation. A function was developed to determine the optimal value of the recovery delay for an optimal inversion-transfer sequence. The validity of these theoretical results was checked experimentally with a solution of N,N-dimethylacetamide in which chemical exchange arises from internal hindered rotation.
authors: CEISAM CNRS UMR 6230, Département de Chimie, Université de Nantes, 2 rue de la Houssiniére, F-44322 Nantes cedex 3, France.
authors: Evelyne
authors: E
authors: Baguet
keywords: chemical exchange; high resolution NMR; inversion transfer; magnetization transfer