title: PR Prolongation and Cardiac 123I-MIBG Uptake Reduction in Parkinson's Disease.
abstract: BACKGROUND
  Cardiac 123I-metaiodobenzylguanidine scintigraphy (MIBG) previously demonstrated an uptake reduction in patients with Parkinson's disease (PD). However, epidemiologic research showed that electrocardiography (ECG) abnormalities occurred prior to motor signs in PD. Here we investigated whether the electrical conduction system of the heart was impaired in PD.
  
  
  METHODS
  Clinical features, ECG and MIBG parameters were analyzed in 191 patients with PD, 42 with multiple system atrophy (MSA) and 124 normal controls (NL).
  
  
  RESULTS
  The PR interval was significantly longer in patients with PD than in NL. The PR interval was significantly negatively correlated with early and delayed heart-to-mediastinum ratios in MIBG scintigraphy in PD and MSA patients. In 19 PD patients with PR prolongation, 17 patients also had abnormal MIBG findings, and the other 2 showed normal MIBG.
  
  
  CONCLUSIONS
  The PR prolongation must show some sympathetic system abnormality because it is mainly controlled by the sympathetic nervous system. PR prolongation supports the objective biomarker value of MIBG for PD diagnosis.
authors: Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan.
authors: Hitoshi
authors: H
authors: Mochizuki
authors: Yuka
authors: Y
authors: Ebihara
authors: Yoshikazu
authors: Y
authors: Ugawa
authors: Nobuyuki
authors: N
authors: Ishii
authors: Akitoshi
authors: A
authors: Taniguchi
authors: Shigeki
authors: S
authors: Nagamachi
authors: Kazutaka
authors: K
authors: Shiomi
authors: Masamitsu
authors: M
authors: Nakazato
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000000981:diagnostic imaging* / Q000209:etiology; D053840:Brugada Syndrome; D000075224:Cardiac Conduction System Disease; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000002:abnormalities* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods; D010300:Parkinson Disease / Q000150:complications* / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine