title: Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds.
abstract: The pathogenesis of intervertebral disc (IVD) degeneration is not fully understood. The biomolecular signaling pathways involved in the IVD degeneration require further investigation. The aim of this study was to investigate the expression of NG2 proteoglycan in the degenerated IVD. IVD samples were obtained from 16 Dachshunds that were confirmed to have IVD herniation and subsequently underwent hemilaminectomy. The samples were subjected to histological and immunohistochemical (IHC) examinations. IHC revealed positive results for the expression of NG2 proteoglycan in all examined samples. The results showed the expression of NG2 proteoglycan by the degenerated IVDs.
authors: Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka 020-8550, Japan.
authors: Mohammed
authors: M
authors: Abdel-Hakiem
authors: Ayuko
authors: A
authors: Yamashita
authors: Ayman
authors: A
authors: Atiba
authors: Yasuhiko
authors: Y
authors: Okamura
authors: Masaaki
authors: M
authors: Katayama
authors: Haroun
authors: H
authors: Youssef
authors: Hiroshi
authors: H
authors: Isomura
authors: Yuji
authors: Y
authors: Uzuka
mesh_terms: D000818:Animals; D000941:Antigens / Q000378:metabolism*; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D007403:Intervertebral Disc / Q000378:metabolism / Q000473:pathology; D055959:Intervertebral Disc Degeneration / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D007796:Laminectomy / Q000662:veterinary; D008297:Male; D011509:Proteoglycans / Q000378:metabolism*; D000099216:Chondroitin Sulfate Proteoglycan 4
chemical_list: D000941:Antigens; D011509:Proteoglycans; D000099216:Chondroitin Sulfate Proteoglycan 4