title: A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease.
abstract: We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4(+) plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p < 0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors: Kyotaro
authors: K
authors: Ohno
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.|Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
authors: Yasuharu
authors: Y
authors: Sato
authors: Department of Ophthalmology, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors: Koh-ichi
authors: K
authors: Ohshima
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors: Katsuyoshi
authors: K
authors: Takata
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors: Tomoko
authors: T
authors: Miyata-Takata
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors: Mai
authors: M
authors: Takeuchi
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors: Yuka
authors: Y
authors: Gion
authors: Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan.
authors: Tomoyasu
authors: T
authors: Tachibana
authors: Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors: Yorihisa
authors: Y
authors: Orita
authors: Department of Immunology, Nara Medical University, Nara, Japan.
authors: Toshihiro
authors: T
authors: Ito
authors: Department of Pathology, Division of Hematopathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors: Steven H
authors: SH
authors: Swerdlow
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors: Tadashi
authors: T
authors: Yoshino
mesh_terms: D000368:Aged; D016207:Cytokines / Q000378:metabolism; D005134:Eye Neoplasms / Q000276:immunology* / Q000473:pathology*; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
chemical_list: D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D007074:Immunoglobulin G; D012333:RNA, Messenger