title: Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer.
abstract: More than 30 regulators of G protein signaling (RGS) proteins encompass the RGS protein superfamily of critical regulators essential to cellular homeostasis. There is enormous structural and functional diversity among the RGS superfamily, and as such they serve a wide range of functions in regulating cell biology and physiology. Recent evidence has suggested roles for multiple RGS proteins in cancer initiation and progression, which has prompted research toward the potential modulation of these proteins as a new approach in cancer therapy. This article will discuss basic RGS molecular pharmacology, summarize the cellular functions and epigenetic regulation of RGS10, review ovarian cancer chemotherapy and describe the role of RGS10 in ovarian cancer survival signaling.
authors: Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, University of Georgia, 240 W Green Street, Athens, GA 30602, USA.
authors: Shelley B
authors: SB
authors: Hooks
authors: Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, University of Georgia, 240 W Green Street, Athens, GA 30602, USA.
authors: Mandi M
authors: MM
authors: Murph
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D044127:Epigenesis, Genetic; D005260:Female; D019204:GTP-Binding Proteins / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D020710:RGS Proteins / Q000032:analysis / Q000235:genetics* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D020710:RGS Proteins; C101113:RGS10 protein, human; D019204:GTP-Binding Proteins