title: Genetic Polymorphism of MMP2 Gene and Susceptibility to Prostate Cancer.
abstract: OBJECTIVE
  The polymorphic genetic variants of matrix metalloproteinase (MMPs) can play critical roles in development and progression of cancer. The purpose of this study was to investigate if any association exists between MMP2 -1306/T and risk of prostate cancer (PCa).
  
  
  METHODS
  This case-control study comprised a total number of 241 subjects, including 102 patients with PCa and 139 controls with benign prostatic hyperplasia (BPH). MMP2 genotypes were detected by RFLP.
  
  
  RESULTS
  There is no significant difference between different genotypes of MMP2 polymorphism and risk of developing PCa (p = 0.08). Although these genotypes increased the risk of developing PCa 79% (CT vs. CC) and 54% (TT vs. CC), none had a significant effect (p = 0.09 and p = 1 respectively). There were no significant differences in genotype frequencies between patients with low and high degrees of PCa (p = 0.4). Therefore, this polymorphism cannot be considered as a protective factor for PCa metastasis. It seems that MMP2 polymorphism has no protective effect on the grading of the tumor (p = 0.8). Our results indicated that MMP2 polymorphism had no role in the vascular invasion of PCa.
  
  
  CONCLUSIONS
  We found no association between MMP2 polymorphism and cancer risk, overall or by grade, stage or age of diagnosis. Finally, there was no association between the different genotypes and PSA plasma levels among cases or controls. Further evaluations with larger samples from our population may illuminate the effects of polymorphisms on PCa risk and thus help early diagnosis, follow-up and prognostic determinations for PCa patients.
authors: Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors: Zahra
authors: Z
authors: Adabi
authors: Urology and Nephrology Research Center (UNRC), Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Seyed Amir
authors: SA
authors: Mohsen Ziaei
authors: Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors: Mahdieh
authors: M
authors: Imani
authors: Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; Urology and Nephrology Research Center (UNRC), Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Mohammad
authors: M
authors: Samzadeh
authors: Urology and Nephrology Research Center (UNRC), Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Behzad
authors: B
authors: Narouie
authors: Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; Urology and Nephrology Research Center (UNRC), Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Seyed Hamid
authors: SH
authors: Jamaldini
authors: Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran.
authors: Mahdi
authors: M
authors: Afshari
authors: Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Majid
authors: M
authors: Safavi
authors: Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors: Mohammad Reza
authors: MR
authors: Roshandel
authors: Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran. Electronic address: mandanahasanzad@yahoo.com.
authors: Mandana
authors: M
authors: Hasanzad
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018450:Disease Progression; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics*; D012306:Risk
chemical_list: D017430:Prostate-Specific Antigen; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
keywords: MMP2; Matrix metalloproteinase; Polymorphism; Prostate cancer