title: Citrifelins A and B, Citrinin Adducts with a Tetracyclic Framework from Cocultures of Marine-Derived Isolates of Penicillium citrinum and Beauveria felina.
abstract: Citrifelins A (1) and B (2), two citrinin adducts possessing a unique tetracyclic framework, were characterized from a coculture of marine-derived fungal isolates of Penicillium citrinum and Beauveria felina. Neither fungus produced these compounds when cultured alone under the same conditions. The structures of these adducts were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assigned on the basis of TDDFT-ECD calculations. A hypothesis that adducts 1 and 2 might be derived from a citrinin derivative through a non-pericyclic Michael reaction is proposed. Compounds 1, 2, and 5 showed inhibitory activities against several human and aquatic pathogens.
authors: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences , Nanhai Road 7, Qingdao 266071, People's Republic of China.|University of Chinese Academy of Sciences , Yuquan Road 19A, Beijing 100049, People's Republic of China.
authors: Ling-Hong
authors: LH
authors: Meng
authors: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences , Nanhai Road 7, Qingdao 266071, People's Republic of China.|University of Chinese Academy of Sciences , Yuquan Road 19A, Beijing 100049, People's Republic of China.
authors: Yang
authors: Y
authors: Liu
authors: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences , Nanhai Road 7, Qingdao 266071, People's Republic of China.
authors: Xiao-Ming
authors: XM
authors: Li
authors: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences , Nanhai Road 7, Qingdao 266071, People's Republic of China.
authors: Gang-Ming
authors: GM
authors: Xu
authors: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , Chunhui Road 17, Yantai 264003, People's Republic of China.
authors: Nai-Yun
authors: NY
authors: Ji
authors: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences , Nanhai Road 7, Qingdao 266071, People's Republic of China.
authors: Bin-Gui
authors: BG
authors: Wang
mesh_terms: D027901:Acanthaceae / Q000382:microbiology; D016980:Aeromonas hydrophila / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D052982:Beauveria / Q000737:chemistry; D002953:Citrinin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018920:Coculture Techniques; D018360:Crystallography, X-Ray; D020609:Edwardsiella tarda / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry; D014733:Vibrio / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; C000603562:citrifelin A; C000603563:citrifelin B; D002953:Citrinin