title: Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome.
abstract: Obesity, insulin resistance (IR), inflammation, and hyperandrogenism may lead to polycystic ovary syndrome (PCOS) and hypertension. Nesfatin-1 (N1) may be related to IR, obesity, and hypertension. Furthermore, a vitamin D (VD) deficiency is associated with hypertension and PCOS. We aimed to investigate N1 and VD levels in PCOS that have an effect on systolic and diastolic blood pressure (BP) and heart rate (HR).This study included 54 patients with PCOS and 48 age-body mass index (BMI)-matched healthy controls. PCOS was diagnosed according to clinical practice guidelines. Ferriman-Gallwey scores (FGS) were calculated, while N1, VD, and other hormonal and biochemical parameters were measured for all subjects. Systolic and diastolic BP was measured as well. HR was calculated using an electrocardiogram.The levels of N1 (p < 0.001), high-sensitivity C-reactive protein (hs-CRP) (p = 0.036), homeostasis model assessment as an index of insulin resistance (HOMA-IR) (p < 0.001), systolic (p < 0.001) and diastolic (p < 0.001) BP and HR (p < 0.001) in the PCOS group were significantly higher than in the control group. However, the VD levels of the PCOS group were lower than the control group (p = 0.004). N1 had a strong positive correlation with BMI, HOMA-IR, hs-CRP, luteinizing hormone, systolic and diastolic BP, and HR. VD levels were negatively correlated with HOMA-IR and luteinizing hormone.Elevated N1 and decreased VD levels may be related to the presence of high-normal BP or hypertension in PCOS subjects.  N1 level may be associated with an increased BP due to its relation to inflammation and IR.
authors: University of Recep Tayyip Erdoğan School of Medicine, Department of Obstetrics and Gynecology. drfigenkir@yahoo.com.
authors: Figen Kir
authors: FK
authors: Sahin
authors: Serap Baydur
authors: SB
authors: Sahin
authors: Ulku Mete
authors: UM
authors: Ural
authors: Medine Cumhur
authors: MC
authors: Cure
authors: Senol
authors: S
authors: Senturk
authors: Yesim Bayoglu
authors: YB
authors: Tekin
authors: Gulsah
authors: G
authors: Balik
authors: Erkan
authors: E
authors: Cure
authors: Suleyman
authors: S
authors: Yuce
authors: Aynur
authors: A
authors: Kirbas
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology*; D014807:Vitamin D / Q000097:blood*; D055815:Young Adult
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D014807:Vitamin D