title: Can an Immediate 2-stage Breast Reconstruction Be Performed After Previous Conservative Surgery and Radiotherapy?
abstract: BACKGROUND
  Prosthetic breast reconstruction is generally considered contraindicated after previous breast irradiation. As a result, patients undergoing a salvage mastectomy for recurrent breast cancer or "risk-reducing" mastectomies after previous conservative surgery and radiotherapy (CS + RT) are usually offered autologous breast reconstruction. However, not all such patients are suitable candidates for a major flap reconstruction. The purpose of this study is to review our results of immediate 2-stage prosthetic breast reconstruction after CS + RT.
  
  
  METHODS
  A retrospective review was undertaken for 671 consecutive patients with prosthetic-only breast reconstruction performed by a single surgeon over a 12.5-year period. Twenty-two patients who qualified for the criteria were audited. Outcomes examined include complications, loss of tissue expander or implant, revisional surgery, and aesthetic result.
  
  
  RESULTS
  Twenty-two patients underwent 33 mastectomies and immediate 2-stage breast reconstructions after previous CS + RT (15 for recurrent cancer and seven "risk-reduction") and 11 contralateral risk-reducing mastectomies. One patient died due to extensive metastatic disease. There was no reconstruction failure. The average breast implant size was 491.7 g (range 220 -685g). Seroma was the most common complication and occurred in 3 of 22 patients (13.6%) after stage 1 and 3 of 21 patients (14.3%) after stage 2 reconstruction. The revisional surgery rate was 28.6%. Aesthetic result was rated as excellent in 9.5%, good in 76.2%, and fair in 14.3%.
  
  
  CONCLUSIONS
  For selected patients, immediate 2-stage prosthetic breast reconstruction can be performed successfully after a salvage mastectomy subsequent to a recurrence after CS + RT.
authors: Department of Plastic and Reconstructive Surgery, Westmead Hospital, Sydney, NSW, Australia; and Macquarie University Cancer Institute, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia.
authors: T C
authors: TC
authors: Lam
authors: Department of Plastic and Reconstructive Surgery, Westmead Hospital, Sydney, NSW, Australia; and Macquarie University Cancer Institute, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia.
authors: F
authors: F
authors: Hsieh
authors: Department of Plastic and Reconstructive Surgery, Westmead Hospital, Sydney, NSW, Australia; and Macquarie University Cancer Institute, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia.
authors: J
authors: J
authors: Salinas
authors: Department of Plastic and Reconstructive Surgery, Westmead Hospital, Sydney, NSW, Australia; and Macquarie University Cancer Institute, Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia.
authors: J
authors: J
authors: Boyages