title: The ABCD2 score may underestimate the short-term risk of stroke in Chinese population: A meta-analysis.
abstract: OBJECTIVE
  The ABCD2 score has been commonly used to triage patients with transient ischemic attack (TIA) who are at high risk for imminent stroke. However, its accuracy in predicting short-term stroke risk among TIA patients in China remains unclear.
  
  
  METHODS
  All eligible studies published up to May 2014 were identified by searching Medline, PubMed, Embase, the China Knowledge Resource Integrated Database (CNKI) and the China Biological Medicine Database (CBM-disc), as well as unpublished articles manually scanned. The strength of the associations between treatments and outcomes was estimated by incorporated risk ratios (RRs) and 95% confidence intervals (CIs) using the Mantel-Haenszel statistical method.
  
  
  RESULTS
  Eight and 32 studies, which validated the value for predicting the risk of stroke 2 and 7 days after TIA respectively, were included. We calculated the RRs and CIs for 2- and 7-day prediction for stroke (low: RR=0.43, 95% CI=0.17-1.10, I2=0%; moderate: RR=0.42, 95% CI=0.26-0.67, I2=0%; high: RR=0.32, 95% CI=0.21-0.48, I2=0%; and low: RR=0.29, 95% CI=0.20-0.44, I2=0%; moderate: RR=0.27, 95% CI=0.23-0.33, I2=0%; high: RR=0.22, 95% CI=0.18-0.27, I2=1%).
  
  
  CONCLUSIONS
  This meta-analysis indicated that the ABCD2 score may highly under-predict the short-term occurrence of stroke after TIA for the Chinese population compared with the original model derived from Caucasian populations, which may lead to neglect of the short-term risk for stroke in the clinical practice.
authors: Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors: Tingting
authors: T
authors: Chu
authors: Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China.
authors: Weidong
authors: W
authors: Yu
authors: Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors: Yingying
authors: Y
authors: Wang
authors: Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors: Na
authors: N
authors: Guo
authors: Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors: Jinting
authors: J
authors: He
authors: Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors: Yankun
authors: Y
authors: Shao
authors: Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors: Jing
authors: J
authors: Mang
authors: Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
authors: Zhongxin
authors: Z
authors: Xu
mesh_terms: D002681:China / Q000453:epidemiology; D006801:Humans; D002546:Ischemic Attack, Transient / Q000453:epidemiology*; D012720:Severity of Illness Index; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology*