title: In vitro antifungal activity of antipsychotic drugs and their combinations with conventional antifungals against Scedosporium and Pseudallescheria isolates.
abstract: In the present study, in vitro antifungal activities of five antipsychotic drugs (i.e., chlorpromazine hydrochloride, CPZ; trifluoperazine hydrochloride, TPZ; amantadine hydrochloride; R-(-)-deprenyl hydrochloride, and valproic acid sodium salt) and five conventional antifungal drugs (i.e., amphotericin B, AMB; caspofungin, CSP; itraconazole; terbinafine, TRB and voriconazole, VRC) were investigated in broth microdilution tests against four clinical and five environmental Scedosporium and Pseudallescheria isolates. When used alone, phenothiazines CPZ and TPZ exerted remarkable antifungal effects. Thus, their in vitro combinations with AMB, CSP, VRC, and TRB were also examined against the clinical isolates. In combination with antifungal agents, CPZ was able to act synergistically with AMB and TRB in cases of one and two isolates, respectively. In all other cases, indifferent interactions were revealed. Antagonism was not observed between the tested agents. These combinations may establish a more effective and less toxic therapy after further in vitro and in vivo studies for Scedosporium and Pseudallescheria infections.
authors: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Szeged, Hungary.
authors: Mónika
authors: M
authors: Homa
authors: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Szeged, Hungary Innsbruck Medical University, Biocenter, Division of Molecular Biology, Innsbruck, Austria galgoczi@gmail.com.
authors: László
authors: L
authors: Galgóczy
authors: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Szeged, Hungary.
authors: Eszter
authors: E
authors: Tóth
authors: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Szeged, Hungary.
authors: Liliána
authors: L
authors: Tóth
authors: King Saud University, Botany and Microbiology Department, Riyadh, Kingdom of Saudi Arabia.
authors: Tamás
authors: T
authors: Papp
authors: King Saud University, Botany and Microbiology Department, Riyadh, Kingdom of Saudi Arabia.
authors: Muthusamy
authors: M
authors: Chandrasekaran
authors: King Saud University, Botany and Microbiology Department, Riyadh, Kingdom of Saudi Arabia.
authors: Shine
authors: S
authors: Kadaikunnan
authors: King Saud University, Botany and Microbiology Department, Riyadh, Kingdom of Saudi Arabia.
authors: Naiyf S
authors: NS
authors: Alharbi
authors: University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Szeged, Hungary King Saud University, Botany and Microbiology Department, Riyadh, Kingdom of Saudi Arabia.
authors: Csaba
authors: C
authors: Vágvölgyi
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004347:Drug Interactions; D004783:Environmental Microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology; D011541:Pseudallescheria / Q000187:drug effects* / Q000302:isolation & purification; D021681:Scedosporium / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D014150:Antipsychotic Agents
keywords: Pseudallescheria spp.; Scedosporium spp.; antipsychotic drugs; drug interactions