title: MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors.
abstract: Identifying novel mechanisms contributing to patient variability of drug response is a major goal of personalized medicine. Epigenetic regulation of gene expression by microRNA (miRNA) impacts a broad range of cellular processes, but knowledge of its regulation of drug-metabolizing enzymes (DMEs) is more limited. This review provides an introduction to miRNA and their functionality and summarizes known miRNA regulation of DME families, including the cytochrome P450s, UDP-glucuronoslytransferases, glutathione-S-transferases, sulfotransferases and aldo-keto reductases, and the transcription factors known to be involved in DME regulation.
authors: a Laboratory of Epidemiology and Population Sciences , National Institutes of Health , Baltimore , MD , USA and.
authors: Douglas F
authors: DF
authors: Dluzen
authors: b Department of Pharmaceutical Sciences , Washington State University , Spokane , WA , USA.
authors: Philip
authors: P
authors: Lazarus
mesh_terms: D000074408:Aldo-Keto Reductases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001711:Biotransformation / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D015971:Gene Expression Regulation, Enzymologic; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D015238:Sulfotransferases / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors; D003577:Cytochrome P-450 Enzyme System; D000074408:Aldo-Keto Reductases; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D015238:Sulfotransferases
keywords: epigenetic regulation; metabolizing enzymes; miRNA; phase I metabolism; phase II metabolism; transcription factors