title: A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake.
abstract: Based on the protonation/deprotonation of poly(β-amino ester) (PAE), mixed-shell micelles (MSMs) with adaptive surfaces could rapidly and reversibly change surface properties to prolong circulation time in blood (pH 7.4) and enhance cellular uptake at tumor sites (pH 6.5).
authors: State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China. shilinqi@nankai.edu.cn.
authors: Tangjian
authors: T
authors: Cheng
authors: Rujiang
authors: R
authors: Ma
authors: Yumin
authors: Y
authors: Zhang
authors: Yuxun
authors: Y
authors: Ding
authors: Jinjian
authors: J
authors: Liu
authors: Hanlin
authors: H
authors: Ou
authors: Yingli
authors: Y
authors: An
authors: Jianfeng
authors: J
authors: Liu
authors: Linqi
authors: L
authors: Shi
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008823:Micelles; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics*; D011522:Protons; D013499:Surface Properties; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D011522:Protons; C507253:poly(beta-amino ester); D004317:Doxorubicin