title: Chronic recurrent multifocal osteomyelitis: a rare skeletal disorder.
abstract: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare non-infectious inflammatory bone disease of unknown aetiology. CRMO mainly affects the metaphyses of long bones and spine in children and young adolescents. It presents with recurrent episodes of bone pain and fever, resembling bacterial osteomyelitis, but cultures of lesions are sterile and it is unresponsive to antibiotic therapy. We report a case of a 3-year-old boy diagnosed with CRMO, who was initially treated for bacterial osteomyelitis, and received prolonged antibiotic therapy for chronic pain, and swelling of mandible and ulna. CRMO should be kept in mind in the differential diagnosis of chronic bone pain and osteomyelitis unresponsive to antibiotic treatment.
authors: Cerrahpasa Medical Faculty, Department of Pediatric Infectious Diseases, Istanbul University, Istanbul, Turkey.
authors: Deniz
authors: D
authors: Aygun
authors: Cerrahpasa Medical Faculty, Department of Pediatric Rheumatology, Istanbul University, Istanbul, Turkey.
authors: Kenan
authors: K
authors: Barut
authors: Cerrahpasa Medical Faculty, Department of Pediatric Infectious Diseases, Istanbul University, Istanbul, Turkey.
authors: Yildiz
authors: Y
authors: Camcioglu
authors: Cerrahpasa Medical Faculty, Department of Pediatric Rheumatology, Istanbul University, Istanbul, Turkey.
authors: Ozgur
authors: O
authors: Kasapcopur
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001842:Bone and Bones / Q000473:pathology*; D002675:Child, Preschool; D057210:Delayed Diagnosis; D003937:Diagnosis, Differential; D000068800:Etanercept / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008334:Mandible / Q000473:pathology; D010000:Osteitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D010019:Osteomyelitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D035583:Rare Diseases; D012008:Recurrence; D014457:Ulna / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000068800:Etanercept