title: Computational Modeling of Neuronal Current MRI Signals with Rat Somatosensory Cortical Neurons.
abstract: Magnetic field generated by active neurons has recently been considered to determine location of neuronal activity directly with magnetic resonance imaging (MRI), but controversial results have been reported about detection of such small magnetic fields. In this study, multiple neuronal morphologies of rat tissue were modeled to investigate better estimation of MRI signal change produced by neuronal magnetic field (NMF). Ten pyramidal neurons from layer II to VI of rat somatosensory area with realistic morphology, biophysics, and neuronal density were modeled to simulate NMF of neuronal tissue, from which effects of NMF on MRI signals were obtained. Neuronal current MRI signals, which consist of relative magnitude signal change (RMSC) and phase signal change (PSC), were at least three and one orders of magnitude less than a tissue with single neuron type, respectively. Also, a reduction in voxel size could increase signal alterations. Furthermore, with selection of zenith angle of external main magnetic field related to tissue surface near to 90°, RMSC could be maximized. This value for PSC would be 90° for small voxel size and zero degree for large ones.
authors: Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran. m_b_mofidi@yahoo.com.
authors: Seyed Mehdi
authors: SM
authors: BagheriMofidi
authors: Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors: Majid
authors: M
authors: Pouladian
authors: Department of Medical Basic Sciences, Faculty of Allied Medicine, IUMS, Tehran, Iran.|Department of Anatomy, Faculty of Medicine, IUMS, Tehran, Iran.
authors: Seyed Behnammodin
authors: SB
authors: Jameie
authors: Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran.
authors: Ali
authors: A
authors: Abbaspour Tehrani-Fard
mesh_terms: D000818:Animals; D003198:Computer Simulation; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D013003:Somatosensory Cortex / Q000378:metabolism / Q000502:physiology*
keywords: Neuronal current MRI; Realistic; Somatosensory; Voxel size