title: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?
abstract: Phytochemicals are a powerful group of chemicals that are derived from natural resource, especially with plants origin. They have shown to exhibit chemoprevention and chemotherapeutic effects not only in cell lines and in animal models of cancer but also some of them are in the clinical trial phase I and II. Despite numerous reports of these phytochemical effects on cancer, an overview of the mechanisms of their action and their effects on various cellular and molecular functions important in the inhibition of cancer progression has been lacking. In this review, we attempt to catalogue various studies to examine the effect of phytochemicals in cancer initiation, promotion, signaling, and epigenetic changes. Because of the numerous studies in these topics, we only pointed out to some examples in each section.
authors: Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA. Electronic address: bathai_z@modares.ac.ir.
authors: S Zahra
authors: SZ
authors: Bathaie
authors: Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Nasim
authors: N
authors: Faridi
authors: Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Ahmad
authors: A
authors: Nasimian
authors: Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Hamid
authors: H
authors: Heidarzadeh
authors: Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA.
authors: Fuyuhiko
authors: F
authors: Tamanoi
keywords: Chemoprevention; Chemotherapeutic; Enzyme inhibition; Epigenetic; Mechanism of action; Signaling pathway