title: Logarithmic intensity compression in fluorescence guided surgery applications.
abstract: The use of fluorescence video imaging to guide surgery is rapidly expanding, and improvements in camera readout dynamic range have not matched display capabilities. Logarithmic intensity compression is a fast, single-step mapping technique that can map the useable dynamic range of high-bit fluorescence images onto the typical 8-bit display and potentially be a variable dynamic contrast enhancement tool. We demonstrate a ∼4.6  times improvement in image quality quantified by image entropy and a dynamic range reduction by a factor of ∼380 by the use of log-compression tools in processing in vivo fluorescence images.
authors: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United States.
authors: Alisha V
authors: AV
authors: DSouza
authors: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United StatesbFujian Normal University, MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory for Photonics Technology, Fuj.
authors: Huiyun
authors: H
authors: Lin
authors: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United States.
authors: Jason
authors: J
authors: Gunn
authors: Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, United StatescGeisel School of Medicine at Dartmouth, Department of Surgery, Hanover, New Hampshire 03755, United States.
authors: Brian W
authors: BW
authors: Pogue
mesh_terms: D000465:Algorithms; D000818:Animals; D044962:Data Compression / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008198:Lymph Nodes / Q000166:cytology* / Q000601:surgery*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods*; D018715:Microscopy, Video / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000379:methods*