title: [Stem cells in orthopaedics].
abstract: Sharing new ideas and approaches is needed to advance basic scientific research as well as the clinical application of stem cells. In this newsletter we present the current knowledge in stem cell research and therapy within the field of orthopaedics, presenting the definitions, types and sources of the stem cells. The second part of this newsletter focuses on the clinical application of stem cells in the therapy of tissues with very limited capacity for self-regeneration; this includes tendons and ligaments, particularly found in rotator cuff rupture. The sever problems associated with articular cartilage repair have lead to the need for the development of clinical research, with the aim of finding efficient clinical applications of stem cell therapy in cartilage defects and osteoarthritis. However in addition to this, such therapy could be used for the regeneration of bone, as in bone defect repair. The clinical outcome of stem cell therapy is a promising option for the treatment of cartilage, bone and tendon defects; however an increased sample size and additional long-term prospective randomised studies are needed to confirm these preliminary results.
authors: Pavel
authors: P
authors: Neckař
authors: Eva
authors: E
authors: Syková
mesh_terms: D016026:Bone Marrow Transplantation / Q000379:methods*; D001861:Bone Regeneration / Q000502:physiology; D002357:Cartilage Diseases / Q000628:therapy; D002358:Cartilage, Articular / Q000166:cytology / Q000293:injuries; D050724:Fractures, Cartilage / Q000628:therapy; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D019637:Orthopedic Procedures / Q000379:methods*; D010003:Osteoarthritis / Q000628:therapy; D011446:Prospective Studies; D057905:Stem Cell Research; D013708:Tendon Injuries / Q000628:therapy
keywords: stem cells - cartilage - bone marrow stem cells - clinical application.