title: [Progressive multifocal leukoencephalopathy following azathioprine and steroid treatment of pulmonary sarcoid disease].
abstract: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system following reactivation of the John-Cunningham-Virus (JVC) in an immunocompromised host. This rare condition is characterized by rapid progressing neurologic symptoms often leading to death. In the following, we report on a rapid evolving deterioration of mental status due to PML in an 53-year-old man during treatment of pulmonary sarcoid disease using azathioprine and steroids. In contrast to reported lethal outcomes, our patient experienced a slow recovery of his cognitive impairment and later on of his palsy following termination of immunosuppression.
authors: Prof. Franzen Institut, Köln.
authors: Damian
authors: D
authors: Franzen
authors: Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Düsseldorf.
authors: Christian
authors: C
authors: Mathys
authors: Zentrum für Neuromodulation an der Neurochirurgischen Klinik, Universitätsklinikum Düsseldorf.
authors: Jan
authors: J
authors: Vesper
authors: Institut für Neuropathologie am Universitätsklinikum, Düsseldorf.
authors: Bastian
authors: B
authors: Malzkorn
authors: Axiogenesis AG, Köln.
authors: Heribert
authors: H
authors: Bohlen
authors: Zentrum für Neurologie und Neuropsychiatrie, LVR-Klinikum Düsseldorf.
authors: Rüdiger J
authors: RJ
authors: Seitz
mesh_terms: D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D017565:Sarcoidosis, Pulmonary / Q000150:complications* / Q000188:drug therapy; D013256:Steroids / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids; D001379:Azathioprine