title: The Role of Soy Phytoestrogens on Genetic and Epigenetic Mechanisms of Prostate Cancer.
abstract: Soy phytoestrogens are dietary components with considerable effects on reducing the incidence of prostate cancer. Epidemiological studies demonstrated that occurrence of prostate cancer is relatively low in Asia and Southern Europe, a status associated with consuming of soy isoflavones, such as genistein, daidzein, and glycitein. Soy phytoestrogens exert their activity on molecular mechanisms, including cell-cycle control, induction of apoptosis, inhibition of angiogenesis, and metastasis. In addition, they have antioxidant activity and show regulatory effect on the expression of genes involved in DNA damage and repair. Furthermore, the epigenetic regulation of gene expression can be modified by soy phytoestrogens. They show regulatory effects on gene activity by altering DNA methylation and/or histone modification patterns. In this chapter, we discuss the role of soy phytoestrogens on the genetic and epigenetic mechanisms of prostate cancer. We attempt to provide further insight in order to understand the underlying mechanisms of protective effects of soy phytoestrogens in preventing prostate cancer.
authors: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Marmara University, Istanbul, Turkey; Department of Oncogenetics, Centre Jean Perrin-CBRV, Clermont-Ferrand, France; EA 4677 "ERTICA," University of Auvergne, Clermont-Ferrand, France.
authors: Seher
authors: S
authors: Karsli-Ceppioglu
authors: Department of Oncogenetics, Centre Jean Perrin-CBRV, Clermont-Ferrand, France; EA 4677 "ERTICA," University of Auvergne, Clermont-Ferrand, France.
authors: Marjolaine
authors: M
authors: Ngollo
authors: Department of Oncogenetics, Centre Jean Perrin-CBRV, Clermont-Ferrand, France; EA 4677 "ERTICA," University of Auvergne, Clermont-Ferrand, France.
authors: Gaëlle
authors: G
authors: Judes
authors: Department of Oncogenetics, Centre Jean Perrin-CBRV, Clermont-Ferrand, France; EA 4677 "ERTICA," University of Auvergne, Clermont-Ferrand, France.
authors: Frédérique
authors: F
authors: Penault-LLorca
authors: Department of Oncogenetics, Centre Jean Perrin-CBRV, Clermont-Ferrand, France; EA 4677 "ERTICA," University of Auvergne, Clermont-Ferrand, France.
authors: Yves-Jean
authors: YJ
authors: Bignon
authors: EA 4677 "ERTICA," University of Auvergne, Clermont-Ferrand, France; Department of Urology, CHU Gabriel Montpied, Clermont-Ferrand, France.
authors: Laurent
authors: L
authors: Guy
authors: Department of Oncogenetics, Centre Jean Perrin-CBRV, Clermont-Ferrand, France; EA 4677 "ERTICA," University of Auvergne, Clermont-Ferrand, France. Electronic address: Dominique.BERNARD-GALLON@cjp.fr.
authors: Dominique
authors: D
authors: Bernard-Gallon
keywords: Epigenetics; Genistein; Isoflavones; Prostate cancer; Soy phytoestrogens