title: Fumarate in DNA repair.
abstract: A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.
authors: Departments of Biochemistry &Molecular Biology and Oncology, Robson DNA Science Centre, Southern Alberta Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.
authors: Susan P
authors: SP
authors: Lees-Miller
mesh_terms: D004260:DNA Repair; D005650:Fumarates / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational
chemical_list: D005650:Fumarates; D006657:Histones