title: Phytol in a pharma-medico-stance.
abstract: This study aims to review phytol (PYT), through published articles, periodicals, magazines and patents, which were retrieved from the PM, SD, WS, SP; DII, WIPO, CIPO, USPTO and INPI databases. Among the 149 articles and 62 patents, 27.52% articles and 87.09% patients were found on the searched topic, PYT and its sources and synthesis and metabolism; then followed by 15.44% and 14.77% articles on PYT in cytotoxicity/cancer/mutagenicity/teratogenicity and PYT in neurological diseases, respectively. In the pharma-medico viewpoint, PYT and its derivatives have been evident to have antimicrobial, cytotoxic, antitumorous, antimutagenic, anti-teratogenic, antibiotic-chemotherapeutic, antidiabetic, lipid lowering, antispasmodic, anticonvulsant, antinociceptive, antioxidant, anti-inflammatory, anxiolytic, antidepressant, immunoadjuvancy, hair growth facilitator, hair fall defense and antidandruff activities. Otherwise, the important biometebolite of PYT is phytanic acid (PA). Evidence shows PA to have cytotoxic, anticancer, antidiabetic, lipid lowering and aniteratogenic activities. In addition, it may be considered as an important biomarker for some diseases such as Refsum's Disease (RD), Sjögren Larsson syndrome (SLS), rhizomelic chondrodysplasia punctata (RZCP), chronic polyneuropathy (CP), Zellweger's disease hyperpipecolic academia (ZDHA) and related diseases. Thus, phytol may be considered as a new drug candidate.
authors: Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550 Teresina, Brazil; Department of Pharmacy, Southern University Bangladesh, 22-Shahid Mirza Lane (E), Academic Building-II, 739/A, Mehedibag Road, Mehedibag, 4000 Chittagong, Bangladesh. Electronic address: rbiotufpi.br@gmail.com.
authors: Md Torequl
authors: MT
authors: Islam
authors: Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550 Teresina, Brazil.
authors: Marcus Vinícius Oliveira Barros
authors: MV
authors: de Alencar
authors: Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550 Teresina, Brazil.
authors: Katia
authors: K
authors: da Conceição Machado
authors: Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550 Teresina, Brazil.
authors: Keylla
authors: K
authors: da Conceição Machado
authors: Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550 Teresina, Brazil.
authors: Ana Amélia
authors: AA
authors: de Carvalho Melo-Cavalcante
authors: Department of Pharmaceutical Sciences, Federal University of Paraíba, CEP 58.051-900 João Pessoa, Paraíba, Brazil.
authors: Damiao Pergentino
authors: DP
authors: de Sousa
authors: Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piauí, 64.049-550 Teresina, Brazil.
authors: Rivelilson Mendes
authors: RM
authors: de Freitas
mesh_terms: D002626:Chemistry, Pharmaceutical; D019992:Databases as Topic; D006801:Humans; D010330:Patents as Topic; D010836:Phytol / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D010836:Phytol
keywords: Biomarker; Databases; Diterpenoid; Drug; Pharmaceutical; Phytol