title: Linguistic Adaptation, Reliability, Validation, and Responsivity of the Chinese Version of Reflux Symptom Index.
abstract: OBJECTIVE
  Currently, there is no cost-effective tool available to diagnose laryngopharyngeal reflux (LPR) in the developing country of China. The aim of this study was to achieve a linguistic adaptation of the Chinese version of the Reflux Symptom Index (RSI-CH).
  
  
  METHODS
  A nonrandomized, controlled, prospective trial.
  
  
  METHODS
  A total of 107 patients at the outpatient clinic of Peking University People's Hospital were enrolled. They were asked to fill out the RSI-CH and underwent fiber-optic laryngoscopy to complete the Reflux Finding Score (RFS). Patients underwent pH monitoring if the RSI-CH was greater than 13 or if the RFS was not less than 7. Patients were treated with Omeprazole 20 mg twice a day for 3 months if the pH monitoring was positive. The reliability (Cronbach alpha coefficient and Spearman correlation analysis), validity (sensitivity, specificity, and positive and negative predictive values), and responsivity of RSI-CH were determined.
  
  
  RESULTS
  RSI-CH had a good reliability (Cronbach alpha coefficient was greater than .7, whereas the test-retest validity for the total score and for each item were 0.750-0.971. The scale had a good criterion validity. The consistency (66.7%), sensitivity (61.76%), and specificity (75%), and the positive and negative predictive values (80.8% and 53.6%) were considered good. The RSI-CH scores changed from 15 to 7 after treatment, and the average score of the controlled group was 6.5.
  
  
  CONCLUSIONS
  The RSI-CH developed and validated by this study can be used as an effective diagnostic tool in identifying differentiating LPR diseases in patients whose native language is Chinese.
authors: Department of Otolaryngology, Peking University People's Hospital, Beijing, China.
authors: Jingjing
authors: J
authors: Li
authors: Department of Otolaryngology, Peking University People's Hospital, Beijing, China. Electronic address: lihongzhang@vip.sina.com.
authors: Lihong
authors: L
authors: Zhang
authors: Department of Clinical Epidemiology, Peking University People's Hospital, Beijing, China.
authors: Chunfang
authors: C
authors: Zhang
authors: Department of Otolaryngology, Peking University People's Hospital, Beijing, China.
authors: Jye Yuan
authors: JY
authors: Cheng
authors: Department of Otolaryngology Head and Neck Surgery Center, Navy Army General Hospital, Beijing, China.
authors: Jinrang
authors: J
authors: Li
authors: Department of Addiction and Mental Health, Rockyview General Hospital, Alberta Health Services, Calgary, Alberta, Canada.
authors: Chieh-Fu
authors: CF
authors: Jeff Cheng
mesh_terms: D002681:China; D050782:Esophageal pH Monitoring; D006785:Hospitals, University; D006801:Humans; D007802:Language; D057045:Laryngopharyngeal Reflux / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D007828:Laryngoscopy; D009853:Omeprazole / Q000008:administration & dosage; D011237:Predictive Value of Tests; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000008:administration & dosage; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D054328:Proton Pump Inhibitors; D009853:Omeprazole
keywords: Laryngopharyngeal Reflux Symptom Index; Laryngopharyngeal reflux; Reliability; Scale; Validity