title: Histological Structure and Vascularity of Hysteroscopically Removed Uterine Septa in Patients With Primary Infertility and Patients With Recurrent Pregnancy Loss.
abstract: OBJECTIVE
  To examine the histological structure and vascularity of uterine septa in patients with unexplained primary infertility and patients with recurrent pregnancy loss (RPL).
  
  
  METHODS
  Case-control study (Canadian Task Force classification II-2).
  
  
  METHODS
  Kasr Al Aini Hospital, Cairo University, Egypt.
  
  
  METHODS
  A total of 41 patients with uterine septa presenting with either unexplained primary infertility or RPL underwent 3-dimensional (3D) and power Doppler (PD) ultrasound to calculate the septum volume, septal vascularization index (VI), and myometrial VI. Hysteroscopically removed septa were examined histologically for myometrial and fibrous tissue content.
  
  
  RESULTS
  Septal characteristics differed between the primary infertility group (24 patients) and the RPL group (17 patients). Mean septal VI was significantly higher in the RPL group compared with the infertility group (18.39% ± 7.57% vs 11.67% ± 4.56%; p = .003), as was septal myometrial area (20.74% ± 5.97% vs 13.57% ± 5.55%; p < .001). In both groups, septal VI was strongly correlated with myometrial VI and myometrial content, but not with fibrous tissue content.
  
  
  CONCLUSIONS
  Uterine septa of patients with RPL are more vascularized and contain more muscular tissue compared with those of patients with primary unexplained infertility.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors: Ghada Abdel Fattah
authors: GA
authors: Abdel Moety
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: hassangaafar@kasralainy.edu.eg.
authors: Hassan Mostafa
authors: HM
authors: Gaafar
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors: Osama
authors: O
authors: Shawki
authors: Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors: Mohamed
authors: M
authors: Faisal
mesh_terms: D000026:Abortion, Habitual / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D000328:Adult; D016022:Case-Control Studies; D004534:Egypt; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007247:Infertility, Female / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D011247:Pregnancy; D012039:Regional Blood Flow; D018615:Ultrasonography, Doppler, Color; D014591:Uterine Diseases / Q000150:complications / Q000473:pathology* / Q000601:surgery; D014599:Uterus / Q000002:abnormalities / Q000098:blood supply / Q000473:pathology*
keywords: Primary unexplained infertility; Recurrent pregnancy loss; Uterine septa