title: Device closure of periprosthetic paravalvular regurgitation.
abstract: Periprosthetic paravalvular regurgitation is an important sequel associated with prosthetic valves whether implanted surgically or via transcatheter approach. They can remain clinically silent or manifest as clinical heart failure, intravascular hemolysis or a combination of both. Periprosthetic defects are becoming increasingly recognized as a source of morbidity and mortality in patients with prosthetic heart valves and in the last few years, the management of this condition has evolved. This review aims to address the current knowledge on the pathophysiology, imaging modalities and management of these defects. It further details the principles, methodology and outcomes of catheter-based device therapy of periprosthetic paravalvular defects.
authors: a Division of Cardiology, Department of Internal Medicine University of Alabama, Birmingham, USA.
authors: Gopal
authors: G
authors: Ghimire
authors: Christopher
authors: C
authors: Capps
authors: Oluseun
authors: O
authors: Alli
mesh_terms: D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery*; D011379:Prognosis; D011475:Prosthesis Failure; D016896:Treatment Outcome; D014463:Ultrasonography
keywords: closure devices; heart failure; periprosthetic defects; prosthetic heart valves; transcatheter therapy