title: Gaseous mediator-based anti-inflammatory drugs.
abstract: Among the most commonly used drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) remain problematic because of their propensity to cause serious adverse events, principally affecting the gastrointestinal tract. In recent years, the discovery of potent anti-inflammatory and cytoprotective effects of endogenous gaseous mediators (nitric oxide, hydrogen sulfide, carbon monoxide) stimulated efforts to develop novel, combination NSAIDs that suppress prostaglandin synthesis (producing anti-inflammatory and analgesic effects) and release one or more of the cytoprotective gaseous mediators. Gaseous mediator-based anti-inflammatory drugs have reached the human clinical trial stage and show considerable promise as a safer option for treating chronic inflammatory diseases.
authors: Department of Histology, Zaporozhye State Medical University, Zaporozhye, Ukraine.
authors: Oksana
authors: O
authors: Sulaieva
authors: Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; Faculty of Medicine, Universidade Camilo Castelo Branco, São Paulo, SP, Brazil. Electronic address: altapharm@hotmail.com.
authors: John L
authors: JL
authors: Wallace
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use*; D002248:Carbon Monoxide / Q000494:pharmacology / Q000627:therapeutic use; D064426:Gasotransmitters / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D006862:Hydrogen Sulfide / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy*; D009569:Nitric Oxide / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D064426:Gasotransmitters; D009569:Nitric Oxide; D002248:Carbon Monoxide; D006862:Hydrogen Sulfide