title: Targeting Head and Neck Cancer Stem Cells: Current Advances and Future Challenges.
abstract: Cancer stem cells (CSCs), or tumor-initiating cells, comprise a subset of tumor cells with demonstrated ability for tumor growth, invasion, metastasis, and resistance to chemotherapy and radiation. Targeting of CSCs remains an attractive yet elusive therapeutic option, with the goal of increasing specificity and effectiveness in tumor eradication, as well as decreasing off-target or systemic toxicity. Research into further characterization and targeted therapy toward head and neck CSCs is an active and rapidly evolving field. This review discusses the current state of research into therapy against head and neck CSCs and future directions for targeted therapy.
authors: Department of Otolaryngology-HNS, University of Michigan, Ann Arbor, MI, USA.
authors: A C
authors: AC
authors: Birkeland
authors: Department of Otolaryngology-HNS, University of Michigan, Ann Arbor, MI, USA.
authors: J H
authors: JH
authors: Owen
authors: Department of Otolaryngology-HNS, University of Michigan, Ann Arbor, MI, USA mepp@umich.edu.
authors: M E
authors: ME
authors: Prince
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D044127:Epigenesis, Genetic / Q000502:physiology; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000502:physiology*
chemical_list: D014408:Biomarkers, Tumor
keywords: HNSCC; cancer biology; cancer genes; characteristics; treatment; tumor initiating cells