title: Relationship between matrix metalloproteinase-9 and common carotid artery intima media thickness.
abstract: Atherosclerosis causes significant morbidity and mortality. Carotid intima media thickness (IMT) predicts future ischaemic strok e incidence. Matrix metalloproteinases (MMPs) play a considerable role in atherosclerosis and hold therapeutic promise as well. To investigate the relationship between serum level of matrix metalloproteinase-9 (MMP-9) and common carotid artery intima media thickness (CCA-IMT) in patients with ischaemic stroke and asymptomatic subjects. Thirty patients with a previous ischaemic stroke and 30 asymptomatic volunteers were recruited. Assessment of vascular risk factors, serum level of MMP-9 and CCA-IMT on both sides was performed. The IMT of both CCAs correlated positively with the serum MMP-9 level in asymptomatic subjects (p = 0.000), even after adjustment for other risk factors. In the patients group, this positive correlation was significant for the right but not for the left CCA (right CCA: p = 0.023, left CCA: p = 0.0284). Fasting blood sugar correlated positively with serum levels of MMP-9 in asymptomatic subjects (p = 0.005) but did not correlate positively in patients. There was no significant correlation between MMP-9 and age or other investigated laboratory risk factors in either the patient or asymptomatic groups. MMP-9 is positively correlated with CCA-IMT both in stroke patients and asymptomatic subjects. This may indicate that MMP-9 is a possible therapeutic target for stroke prevention.
authors: Neurology Department, Cairo University, 49 Misr Hilwan Elzraai Street, Maadi, Cairo, 2218, Egypt.
authors: Maged
authors: M
authors: Abdelnaseer
authors: Neurology Department, Cairo University, 49 Misr Hilwan Elzraai Street, Maadi, Cairo, 2218, Egypt.
authors: Nervana
authors: N
authors: Elfayomi
authors: Neurology Department, Cairo University, 49 Misr Hilwan Elzraai Street, Maadi, Cairo, 2218, Egypt. emaan_neuro@yahoo.com.
authors: Eman H
authors: http://orcid.org/0000-0002-7486-7593
authors: EH
authors: Esmail
authors: Chemical and Clinical Pathology Department, Cairo University, Cairo, Egypt.
authors: Manal M
authors: MM
authors: Kamal
authors: Internal Medicine Department, Cairo University, Cairo, Egypt.
authors: Ahmed
authors: A
authors: Hamdy
authors: Internal Medicine Department, Cairo University, Cairo, Egypt.
authors: Rasha M Abdel
authors: RMA
authors: Samie
authors: Neurology Department, Cairo University, 49 Misr Hilwan Elzraai Street, Maadi, Cairo, 2218, Egypt.
authors: Enji
authors: E
authors: Elsawy
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002545:Brain Ischemia / Q000097:blood* / Q000000981:diagnostic imaging*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000000981:diagnostic imaging*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: Atherosclerosis; Carotid; MMP-9; Media thickness; Metalloproteinase