Biogenesis of the lysosome-derived vacuole containing Coxiella burnetii.
Coxiella burnetii utilizes a Type IV Secretion System (T4SS) to modify host endomembrane transport systems to form a unique lysosome-derived niche called the Coxiella-containing vacuole (CCV). Although the CCV has lysosomal properties, this organelle displays distinct characteristics such as homotypic fusion and a cholesterol enriched limiting membrane, in addition to robustly interacting with autophagosomes. This review describes recent advances in understanding CCV biogenesis and the mechanisms C. burnetii employs to maintain this unique compartment.
Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA.
Lara J
LJ
Kohler
Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA. Electronic address: craig.roy@yale.edu.
Craig R
CR
Roy
D016997:Coxiella burnetii / Q000276:immunology / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D008247:Lysosomes / Q000382:microbiology*; D010588:Phagosomes / Q000382:microbiology*; D011778:Q Fever / Q000382:microbiology / Q000473:pathology; D000069319:Type IV Secretion Systems; D014617:Vacuoles / Q000382:microbiology*
D000069319:Type IV Secretion Systems
Autophagy; Coxiella burnetii; Coxiella-containing vacuole; T4SS; Traffic