Associations among ancestry, geography and breast cancer incidence, mortality, and survival in Trinidad and Tobago.
Breast cancer (BC) is the most common newly diagnosed cancer among women in Trinidad and Tobago (TT) and BC mortality rates are among the highest in the world. Globally, racial/ethnic trends in BC incidence, mortality and survival have been reported. However, such investigations have not been conducted in TT, which has been noted for its rich diversity. In this study, we investigated associations among ancestry, geography and BC incidence, mortality and survival in TT. Data on 3767 incident BC cases, reported to the National Cancer Registry of TT, from 1995 to 2007, were analyzed in this study. Women of African ancestry had significantly higher BC incidence and mortality rates (


BACKGROUND
66.96;


RESULTS
30.82 per 100,000) compared to women of East Indian (


BACKGROUND
41.04, MORTALITY: 14.19 per 100,000) or mixed ancestry (


BACKGROUND
36.72, MORTALITY: 13.80 per 100,000). Geographically, women residing in the North West Regional Health Authority (RHA) catchment area followed by the North Central RHA exhibited the highest incidence and mortality rates. Notable ancestral differences in survival were also observed. Women of East Indian and mixed ancestry experienced significantly longer survival than those of African ancestry. Differences in survival by geography were not observed. In TT, ancestry and geographical residence seem to be strong predictors of BC incidence and mortality rates. Additionally, disparities in survival by ancestry were found. These data should be considered in the design and implementation of strategies to reduce BC incidence and mortality rates in TT.
Oncology Division, Washington University School of Medicine, St. Louis, Missouri.|Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Wayne A
WA
Warner
Oncology Division, Washington University School of Medicine, St. Louis, Missouri.
Robert L
RL
Morrison
California State University, Los Angeles, California.
Tammy Y
TY
Lee
University of Connecticut, Storrs, California.
Tanisha M
TM
Williams
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri.
Shelina
S
Ramnarine
Dr. Elizabeth Quamina Cancer Registry, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad and Tobago.
Veronica
V
Roach
California State University, Los Angeles, California.
Simeon
S
Slovacek
Department of Clinical Surgical Sciences, Faculty of Medical Sciences, University of the West Indies, Trinidad and Tobago.
Ravi
R
Maharaj
Department of Clinical Surgical Sciences, Faculty of Medical Sciences, University of the West Indies, Trinidad and Tobago.
Nigel
N
Bascombe
Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Melissa L
ML
Bondy
Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Matthew J
MJ
Ellis
Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Adetunji T
AT
Toriola
Public Health and Primary Care Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, University of the West Indies, Trinidad and Tobago.
Allana
A
Roach
Rutgers School of Public Health and Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey.
Adana A M
AA
Llanos
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D005260:Female; D005843:Geography; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009026:Mortality; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011159:Population Surveillance; D016016:Proportional Hazards Models; D012042:Registries; D012307:Risk Factors; D014300:Trinidad and Tobago / Q000453:epidemiology / Q000208:ethnology
Ancestry; Caribbean; Trinidad and Tobago; breast cancer; geography; incidence; mortality; survival