Microvascular anatomy of the cerebellar parafloccular perforating space.
OBJECTIVE
The cerebellopontine angle is a common site for tumor growth and vascular pathologies requiring surgical manipulations that jeopardize cranial nerve integrity and cerebellar and brainstem perfusion. To date, a detailed study of vessels perforating the cisternal surface of the middle cerebellar peduncle-namely, the paraflocculus or parafloccular perforating space-has yet to be published. In this report, the perforating vessels of the anterior inferior cerebellar artery (AICA) in the parafloccular space, or on the cisternal surface of the middle cerebellar peduncle, are described to elucidate their relevance pertaining to microsurgery and the different pathologies that occur at the cerebellopontine angle.


METHODS
Fourteen cadaveric cerebellopontine cisterns (CPCs) were studied. Anatomical dissections and analysis of the perforating arteries of the AICA and posterior inferior cerebellar artery at the parafloccular space were recorded using direct visualization by surgical microscope, optical histology, and scanning electron microscope. A comprehensive review of the English-language and Spanish-language literature was also performed, and findings related to anatomy, histology, physiology, neurology, neuroradiology, microsurgery, and endovascular surgery pertaining to the cerebellar flocculus or parafloccular spaces are summarized.


RESULTS
A total of 298 perforating arteries were found in the dissected specimens, with a minimum of 15 to a maximum of 26 vessels per parafloccular perforating space. The average outer diameter of the cisternal portion of the perforating arteries was 0.11 ± 0.042 mm (mean ± SD) and the average length was 2.84 ± 1.2 mm. Detailed schematics and the surgical anatomy of the perforating vessels at the CPC and their clinical relevance are reported.


CONCLUSIONS
The parafloccular space is a key entry point for many perforating vessels toward the middle cerebellar peduncle and lateral brainstem, and it must be respected and protected during surgical approaches to the cerebellopontine angle.
Department of Neuroscience, Clinical and Surgical Neurology, School of Medicine, National University of Cuyo, Mendoza, Argentina;
Pablo
P
Sosa
Departments of Neurosurgery and Electrical Engineering, Wayne State University, Detroit; and.
Manuel
M
Dujovny
Departments of Neurosurgery and Electrical Engineering, Wayne State University, Detroit; and.
Ibe
I
Onyekachi
Departments of Neurosurgery and Electrical Engineering, Wayne State University, Detroit; and.
Noressia
N
Sockwell
Department of Neuroscience, Clinical and Surgical Neurology, School of Medicine, National University of Cuyo, Mendoza, Argentina;
Fabián
F
Cremaschi
Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan.
Luis E
LE
Savastano
D002102:Cadaver; D002196:Capillaries / Q000033:anatomy & histology*; D002528:Cerebellar Neoplasms / Q000473:pathology; D002530:Cerebellopontine Angle / Q000033:anatomy & histology / Q000098:blood supply; D002531:Cerebellum / Q000033:anatomy & histology* / Q000098:blood supply*; D002536:Cerebral Arteries / Q000033:anatomy & histology; D002560:Cerebrovascular Circulation; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology; D008833:Microcirculation; D008866:Microsurgery / Q000379:methods; D019635:Neurosurgical Procedures / Q000379:methods; D011149:Pons / Q000033:anatomy & histology / Q000098:blood supply
AICA = anterior inferior cerebellar artery; CN = cranial nerve; CPA = cerebellopontine angle; CPC = cerebellopontine cistern; PICA = posterior inferior cerebellar artery; SCA = superior cerebellar artery; anatomy; anterior inferior cerebellar artery; cerebellopontine angle; cerebellopontine cistern; cerebellum; middle cerebellar peduncle; parafloccular perforating space; perforating vessels; posterior inferior cerebellar artery