[Recurrence of Anaplastic Lymphoma Kinase Positive Lung Cancer Nineteen-year after the Primary Surgery].
A 77-years-old man who underwent middle lobectomy for lung adenocarcinoma in our hospital 19 years ago. p-Stage IA was pointed out multiple nodules in bilateral lung fields on a medical examination. Computed tomography scan revealed a tumor measuring 34×34 mm in size in the right lower lung and other 40 small pulmonary nodules. Characteristic pattern of metastatic adenocarcinoma from the previous lung cancer was pathologically demonstrated. Immunostaining revealed anaplastic lymphoma kinase (ALK) positivity of the both specimens, which determined the diagnosis of recurrence. Long-team postoperative follow-up for ALK positive lung cancer patients is considered to be necessary especially for younger patients.
Department of Thoracic Surgery, Aichi Cancer Center Aichi Hospital, Okazaki, Japan.
Junzo
J
Ishida
Haruko
H
Suzuki
Yuka
Y
Kitamura
Tatsuo
T
Uchida
D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000077548:Anaplastic Lymphoma Kinase; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local; D011013:Pneumonectomy; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis*; D013997:Time Factors
C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases