Role of neovibsanin scaffold in preservation of spatial cognitive functions of rats with chronic epilepsy.
The effect of neovibsanin scaffold (NS) on the spatial cognitive functions of rats with lobal cerebrovascular hypoperfusion was investigated. Rats were divided into long-term memory (LTM) and short-term memory (STM) groups with 15 rats in each group. The groups were subdivided into 3 groups: control group comprised of 5 rats without surgery, untreated group of 5 rats left without treatment after 2OV, and NS treatment group with 5 rats receiving 5 mg/kg daily for 12 weeks of 2VO operation. NS-treatment caused a marked decrease in the escape latency time and total distance travelled in the treatment group compared to untreated group which was evident from the working memory test. The animals of treatment group also showed significant improvement over that of untreated group in maze test performance. Furthermore, NS treatment also resulted in significant improvement in the probe memory test performance in treatment group compared to untreated group. These findings suggest that NS exhibits therapeutic effect on the spatial cognitive preservation in rats with chronic epilepsy.
Department of Neurology, The Affilated Hospital of Qingdao University Qingdao 266071, China.
Li-Quan
LQ
Dong
Department of Hygiene, Women and Children's Hospital of Weihai City Weihai 264200, China.
Li-Li
LL
Yan
Department of Neurology, The Affilated Hospital of Qingdao University Qingdao 266071, China.
Xu-Dong
XD
Pan
Department of Neurology, 117 Hospital of People's Liberation Army Hangzhou 310013, China.
Jin-Hua
JH
Hu
Department of Neurology, Zhejiang Provincial Hospital of TCM Hangzhou 310013, China.
Jun-Wei
JW
Zhang
D000818:Animals; D002908:Chronic Disease; D003071:Cognition / Q000187:drug effects*; D004195:Disease Models, Animal; D004224:Diterpenes / Q000494:pharmacology*; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D004924:Escape Reaction; D018782:Maze Learning / Q000187:drug effects; D057567:Memory, Long-Term / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D018697:Nootropic Agents / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D013037:Spatial Behavior / Q000187:drug effects*; D013997:Time Factors
D004224:Diterpenes; D018697:Nootropic Agents
Chronic epilepsy; Morris water maze; cognitive; escape latency; working memory test