The role of microRNAs in enteroviral infections.
The genus Enterovirus, a member of the Picornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection of Enterovirus, such as enterovirus 71, coxsackievirus B3 and other Enterovirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection.
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, China.
Jing
J
Wu
Department of Clinical Laboratory, Zhenjiang Center for Disease Control and Prevention, Zhenjiang, Jiangsu Province, China.
Li
L
Shen
Department of Clinical Laboratory, Zhenjiang First People's Hospital, Jiangsu Province, China.
Jianguo
J
Chen
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, China.
Huaxi
H
Xu
Department of Clinical Laboratory, Zhenjiang Center for Disease Control and Prevention, Zhenjiang, Jiangsu Province, China; School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, China. Electronic address: maolingxiang@aliyun.com.
Lingxiang
L
Mao
D004769:Enterovirus Infections / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D010849:Picornaviridae / Q000235:genetics / Q000472:pathogenicity; D014779:Virus Replication / Q000235:genetics
D035683:MicroRNAs
Enterovirus; Infection; MicroRNAs