[Biological activity of selenorganic compounds at heavy metal salts intoxication].
Possible mechanisms of the antitoxic action of organoselenium compounds in heavy metal poisoning have been considered. Heavy metal toxicity associated with intensification of free radical oxidation, suppression of the antioxidant system, damage to macromolecules, mitochondria and the genetic material can cause apoptotic cell death or the development of carcinogenesis. Organic selenium compounds are effective antioxidants during heavy metal poisoning; they exhibit higher bioavailability in mammals than inorganic ones and they are able to activate antioxidant defense, bind heavy metal ions and reactive oxygen species formed during metal-induced oxidative stress. One of promising organoselenium compounds is diacetophenonyl selenide (DAPS-25), which is characterized by antioxidant and antitoxic activity, under conditions including heavy metal intoxication.
Razumovskiy Saratov State Medical University, Saratov, Russia.
N Y
NY
Rusetskaya
Razumovskiy Saratov State Medical University, Saratov, Russia.
V B
VB
Borodulin
D000818:Animals; D000931:Antidotes / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002104:Cadmium / Q000633:toxicity; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology*; D000075322:Heavy Metal Poisoning; D006801:Humans; D007854:Lead / Q000633:toxicity; D008628:Mercury / Q000633:toxicity; D019216:Metals, Heavy / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016566:Organoselenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D011041:Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D012492:Salts / Q000037:antagonists & inhibitors* / Q000633:toxicity
D000931:Antidotes; D000975:Antioxidants; D002614:Chelating Agents; D019216:Metals, Heavy; D016566:Organoselenium Compounds; D017382:Reactive Oxygen Species; D012492:Salts; D002104:Cadmium; D007854:Lead; D008628:Mercury
antitoxic activity; diacetophenonylselenide (DAPS-25); heavy metals; selen; selenorganic compounds