Structural bone allograft fractures in oncological procedures.
OBJECTIVE
We report our experience analysing the risk of fracture amongst allografts in limb-preserving surgery for bone tumours.


METHODS
We retrospectively reviewed our experience with bone allograft and its major complications when used for limb -preserving operations for bone tumours. Forty-one structural allografts were performed in 39 patients between 1992 and 2012. Minimum follow-up was 20 months. Massive allografts have a high complication rate.


RESULTS
Excluding infection and nonunion, five acute fractures were found. All fractures occurred after the graft-host junction was united. Local factors-such as graft preservation, weight bearing, fixation to the host or systemic factors such as adjuvant treatments (chemotherapy or radiotherapy)-influence fracture rate. In our study, four patients achieved consolidation with internal fixation and autologous iliac-crest graft, whilst only one required graft exchange.


CONCLUSIONS
There is no general consensus as to when to treat fractures using open reduction and internal fixation or by exchanging the allograft. Higher fracture rate in relation to systemic treatment was found.


CONCLUSIONS
Massive structural allograft reconstruction still has a place in limb-preserving surgery, with an acceptable fracture rate and a durable solution.
Musculoskeletal Oncology Unit, Department of Orthopaedics & Traumatology, Hospital Clínico San Carlos, C. Prof. Martin Lagos s/n., 28040, Madrid, Spain. jagueropa@hotmail.com.
Javier
J
Garcia-Coiradas
Musculoskeletal Oncology Unit, Department of Orthopaedics & Traumatology, Hospital Clínico San Carlos, C. Prof. Martin Lagos s/n., 28040, Madrid, Spain.
Roberto
R
Garcia-Maroto
Musculoskeletal Oncology Unit, Department of Orthopaedics & Traumatology, Hospital Clínico San Carlos, C. Prof. Martin Lagos s/n., 28040, Madrid, Spain.
Juan Luis
JL
Cebrian
Department of Orthopaedics & Traumatology, Hospital Clínico San Carlos, Universidad Complutense Madrid, Madrid, Spain.
Luis
L
Lopez-Duran
D000293:Adolescent; D000328:Adult; D000368:Aged; D064591:Allografts; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation / Q000009:adverse effects*; D002648:Child; D005260:Female; D005593:Fracture Fixation, Internal; D050723:Fractures, Bone / Q000209:etiology / Q000601:surgery*; D006801:Humans; D023821:Limb Salvage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014184:Transplantation, Homologous / Q000009:adverse effects; D055815:Young Adult
Allograft fracture; Bone tumour; Structural allograft