Regional homogeneity changes in patients with primary insomnia.
OBJECTIVE
The study aimed to explore the regional spontaneous activity changes in primary insomnia (PI) patients.


METHODS
Based on the resting-state fMRI datasets acquired from 59 PI patients and 47 healthy controls, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the Pittsburgh Sleep Quality Index (PSQI), the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) were investigated with Pearson correlation analysis.


RESULTS
In PI patients, we found increased ReHo in the left insula, right anterior cingulate gyrus, bilateral precentral gyrus and left cuneus, as well as decreased ReHo in the right middle cingulate cortex and left fusiform (p < 0.05, AlphaSim-corrected). We also found a significant positive correlation between increased ReHo in the left insula and SAS scores, decreased ReHo in the right middle cingulated cortex and SDS, SAS scores as well as a negative correlation between increased ReHo in the right precentral gyrus and SDS scores (p < 0.05).


CONCLUSIONS
Our study found abnormal spontaneous activities in multiple brain regions, especially in emotion-related areas in PI patients. Alterative activities in these regions might contribute to an understanding the intrinsic functional architecture of insomnia and its clinical features.


CONCLUSIONS
• Regional spontaneous activity changes were detected in PI patients. • Decreased or increased ReHo of some regions was identified in PI patients. • Significant correlations between mean ReHo and SDS scores were found.
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, The Third Clinical Medical College of Southern Medical University, Guangzhou, People's Republic of China.
Tianyue
T
Wang
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China.
Shumei
S
Li
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China. GH.jiang2002@163.com.
Guihua
G
Jiang
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China.
Chulan
C
Lin
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China.
Meng
M
Li
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China.
Xiaofen
X
Ma
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China.
Wenfeng
W
Zhan
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China.
Jin
J
Fang
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China.
Liming
L
Li
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China.
Cheng
C
Li
Guangdong No. 2 Provincial People's Hospital of Southern Medical University, Guangzhou, 510317, People's Republic of China.
Junzhang
J
Tian
D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis*
Primary insomnia; Regional homogeneity; Resting-state; Spontaneous activity; fMRI