Lewis Acid Mediated Trifluoromethylthio Lactonization/Lactamization.
A highly selective Lewis acid mediated trifluoromethylthio lactonization/lactamization of olefins is described. The reaction was proposed to proceed via a thiiranium ion intermediate, which was further attacked by the carboxylic acid or amide to generate the corresponding trifluoromethylthiolated lactone/lactam.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
Chunfa
C
Xu
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
Qilong
Q
Shen