Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014.
Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes of pneumococcal strains causing IPD in children in Turkey and emphasize the change in the serotypes before and after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7) was included and PCV-13 was newly changed in Turkish National Immunization Program. Streptococcus pneumoniae strains were isolated at 22 different hospitals of Turkey, which provide healthcare services to approximately 65% of the Turkish population. Of the 335 diagnosed cases with S. pneumoniae over the whole period of 2008-2014, the most common vaccine serotypes were 19F (15.8%), 6B (5.9%), 14 (5.9%), and 3 (5.9%). During the first 5 y of age, which is the target population for vaccination, the potential serotype coverage ranged from 57.5 % to 36.8%, from 65.0% to 44.7%, and from 77.4% to 60.5% for PCV-7, PCV-10, and PCV-13 in 2008-2014, respectively. The ratio of non-vaccine serotypes was 27.2% in 2008-2010 whereas was 37.6% in 2011-2014 (p=0.045). S. penumoniae serotypes was less non-susceptible to penicillin as compared to our previous results (33.7 vs 16.5 %, p=0.001). The reduction of those serotype coverage in years may be attributed to increasing vaccinated children in Turkey and the increasing non-vaccine serotype may be explained by serotype replacement. Our ongoing IPD surveillance is a significant source of information for the decision-making processes on pneumococcal vaccination.
a Department of Pediatric Infectious Diseases ; Hacettepe University Faculty of Medicine ; Ankara , Turkey.
Mehmet
M
Ceyhan
a Department of Pediatric Infectious Diseases ; Hacettepe University Faculty of Medicine ; Ankara , Turkey.
Yasemin
Y
Ozsurekci
b Department of Microbiology and Clinical Microbiology ; Istanbul University Faculty of Medicine ; Istanbul , Turkey.
Nezahat
N
Gürler
b Department of Microbiology and Clinical Microbiology ; Istanbul University Faculty of Medicine ; Istanbul , Turkey.
Lütfiye
L
Öksüz
c Department of Microbiology and Clinical Microbiology ; Ege University Faculty of Medicine ; Izmir , Turkey.
Sohret
S
Aydemir
d Microbiology Laboratory; Dr. Sami Ulus Children's Health and Diseases Training and Research Hospital ; Ankara , Turkey.
Sengul
S
Ozkan
e Microbiology; Konya Training and Research Hospital ; Konya , Turkey.
Serife
S
Yuksekkaya
f Department of Pediatric Infectious Diseases ; Selçuk University Faculty of Medicine ; Konya , Turkey.
Melike
M
Keser Emiroglu
g Department of Medical Microbiology ; Akdeniz University Faculty of Medicine ; Antalya , Turkey.
Meral
M
Gültekin
h Department of Microbiology ; Çukurova University Faculty of Medicine ; Adana , Turkey.
Akgün
A
Yaman
i Department of Microbiology , Osmangazi University Faculty of Medicine , Izmir , Turkey.
Abdurrahman
A
Kiremitci
j Department of Microbiology ; Ondokuz Mayıs University Faculty of Medicine ; Samsun , Turkey.
Keramettin
K
Yanık
j Department of Microbiology ; Ondokuz Mayıs University Faculty of Medicine ; Samsun , Turkey.
Arzu
A
Karli
k Microbiology Laboratory; Sanliurfa Children's Hospital ; Sanliurfa , Turkey.
Hatice
H
Ozcinar
l Department of Medical Microbiology ; Karadeniz Technical University Faculty of Medicine ; Trabzon , Turkey.
Faruk
F
Aydin
l Department of Medical Microbiology ; Karadeniz Technical University Faculty of Medicine ; Trabzon , Turkey.
Gulcin
G
Bayramoglu
m Department of Microbiology ; Gaziantep University Faculty of Medicine ; Gaziantep , Turkey.
Yasemin
Y
Zer
n Department of Microbiology ; Dokuzeylül University Faculty of Medicine ; Izmir , Turkey.
Zeynep
Z
Gulay
o Microbiology Laboratory; Gaziantep Children's Hospital ; Gaziantep , Turkey.
Efgan Dogan
ED
Gayyurhan
p Department of Microbiology ; Sutcuimam University Faculty of Medicine ; Kahramanmaras , Turkey.
Mustafa
M
Gül
q Department of Medical Microbiology ; Uludağ University Faculty of Medicine ; Bursa , Turkey.
Cüneyt
C
Özakın
r Department of Microbiology ; Yüzüncü Yıl University Faculty of Medicine Training Hospital ; Van , Turkey.
Hüseyin
H
Güdücüoğlu
s Central Laboratory, Bacteriology; Erciyes University Faculty of Medicine ; Kayseri , Turkey.
Duygu
D
Perçin
t Department of Microbiology ; Dicle University Faculty of Medicine ; Diyarbakir , Turkey.
Nezahat
N
Akpolat
u Department of Medical Microbiology ; Mersin University Faculty of Medicine ; Mersin , Turkey.
Candan
C
Ozturk
v Department of Pediatrics ; Istanbul University Cerrahpasa Faculty of Medicine ; Istanbul , Turkey.
Yıldız
Y
Camcıoğlu
a Department of Pediatric Infectious Diseases ; Hacettepe University Faculty of Medicine ; Ankara , Turkey.
Eda
E
Karadağ Öncel
a Department of Pediatric Infectious Diseases ; Hacettepe University Faculty of Medicine ; Ankara , Turkey.
Melda
M
Çelik
w Microbiology Laboratory; Dr. Dogan Baran Hospital for Women's and Children's Diseases ; Niğde , Turkey.
Laser
L
Şanal
x Department of Microbiology ; Ataturk University Faculty of Medicine ; Erzurum , Turkey.
Hakan
H
Uslu
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002675:Child, Preschool; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine / Q000276:immunology*; D006761:Hospitals; D006801:Humans; D017589:Immunization Programs; D008297:Male; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011446:Prospective Studies; D065288:Serogroup; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D014421:Turkey / Q000453:epidemiology; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000276:immunology*
C586648:10-valent pneumococcal conjugate vaccine; C538862:13-valent pneumococcal vaccine; D000900:Anti-Bacterial Agents; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
S. pneumoniae; Turkey; epidemiology; serotypes; surveillance