Efficacy and safety of endoscopic submucosal dissection for superficial colorectal tumors more than 50 mm in diameter.
OBJECTIVE
The feasibility of endoscopic submucosal dissection (ESD) for large superficial colorectal tumors is undefined. The aim of this study was to assess the outcomes for patients undergoing ESD of superficial colorectal tumors larger than 50 mm.


METHODS
A total of 472 patients who underwent ESD for superficial colorectal tumors from 2010 to 2014 were enrolled. We retrospectively reviewed their records.


RESULTS
We compared patients with 20-mm to 50-mm lesions and those with lesions >50 mm regarding demographics, the ESD procedure, and histopathology. Among patients with lesions >50 mm, laterally spreading tumors nongranular and protruded types were uncommon. Histopathologically, deeply invasive (≥1000 μm) submucosal carcinomas were more frequent in lesions >50 mm (14% [10/70] vs 5% [20/402], P < .01). Technically, en bloc resection was successfully accomplished in 99% of patients (69/70). Although the total dissection time for lesions >50 mm was significantly longer than for lesions 20 mm to 50 mm (mean ± SD, 157 ± 114 minutes vs 68 ± 50 min; P < .01), dissection speed for lesions >50 mm was significantly faster than for lesions 20 mm to 50 mm (P < .01). There were no significant differences in en bloc R0 resection rate comparing both groups (>50 mm, 83% vs 20 mm to 50 mm, 87%; P = .31). No perforations or postoperative bleeding occurred in patients with lesions >50 mm. Post-ESD colorectal strictures requiring intervention did not develop in any patient.


CONCLUSIONS
ESD for superficial colorectal tumors >50 mm is feasible. ESD of these lesions had a high R0 resection rate and a low adverse event rate. En bloc resection by ESD provides adequate pathological specimens and may limit the need for surgical intervention.
Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Yoshikazu
Y
Hayashi
Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan; Shinozaki Medical Clinic, Tochigi, Japan.
Satoshi
S
Shinozaki
Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Keijiro
K
Sunada
Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Hiroyuki
H
Sato
Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Yoshimasa
Y
Miura
Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Yuji
Y
Ino
Department of Surgery, Jichi Medical University, Tochigi, Japan.
Hisanaga
H
Horie
Department of Pathology, Jichi Medical University, Tochigi, Japan.
Noriyoshi
N
Fukushima
Department of Surgery, Jichi Medical University, Tochigi, Japan.
Alan K
AK
Lefor
Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Hironori
H
Yamamoto
D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery*; D000069916:Endoscopic Mucosal Resection / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D019106:Postoperative Hemorrhage / Q000453:epidemiology; D012189:Retrospective Studies; D047368:Tumor Burden