HLA-A gene polymorphisms contribute to osteoporosis susceptibility in postmenopausal Han Chinese women.
Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. Prompted by these findings, this study was designed to explore the associations between HLA-A gene polymorphisms and postmenopausal osteoporosis in the Han Chinese population. The polymerase chain reaction-sequence-based typing method was used for DNA genotyping at the HLA-A locus in 70 patients with postmenopausal osteoporosis and 73 healthy controls. We identified 17 HLA-A alleles in patients with postmenopausal osteoporosis and 20 HLA-A alleles in control subjects. Furthermore, we found that the frequency of the HLA-A* 02:07 allele was significantly higher in patients with postmenopausal osteoporosis than in control subjects (P = 0.023), and the relative risk was 4.065 (95% confidence interval = 1.109-14.893). Our study provides supportive evidence for the contribution of HLA-A gene polymorphisms to the susceptibility to postmenopausal osteoporosis and suggests that HLA-A* 02:07 is likely an important genetic risk factor for postmenopausal osteoporosis in the Han Chinese population.
Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
S M
SM
Li
Department of Emergency, Xi'an Jiaotong University Medical College Affiliated Red Cross Hospital, Xi'an, China.
H
H
Guo
Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
H J
HJ
Yang
Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, China.
M Q
MQ
Lv
Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, China zhoudx2010@163.com.
D X
DX
Zhou
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000235:genetics; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000097:blood / Q000235:genetics*
D015234:HLA-A Antigens