Multifunctional theranostic nanoplatform for cancer combined therapy based on gold nanorods.
Nanomaterials that integrate diagnostic and therapeutic functions within a single nanoplatform promise great advances in revolutionizing cancer therapy. A smart multifunctional theranostic drug-delivery system (DDS) based on gold nanorods (abbreviated as GNR/TSDOX) is designed for cancer-targeted imaging and imaging-guided therapy. In this intelligent theranostic DDS, the active targeting ligand biotin is introduced to track cancer sites in vivo. With the aid of photothermal/photoacoustic imaging, GNR/TSDOX can ablate cancer specifically and effectively. When stimulated with a single near-infrared (NIR) light source, this NIR light energy is effectively absorbed and converted into heat by GNR/TSDOX for localized photothermal therapy and the increase in temperature also further triggers the cascaded release of the anticancer drug for combined thermo-chemotherapy. More importantly, the in vivo cure effect can be well guided by regulating the irradiation time and intensity of the NIR light.
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
Wei-Hai
WH
Chen
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, P. R. China.
Cai-Xia
CX
Yang
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
Wen-Xiu
WX
Qiu
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
Guo-Feng
GF
Luo
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
Hui-Zhen
HZ
Jia
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
Qi
Q
Lei
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, P. R. China.
Xiao-Yong
XY
Wang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, P. R. China.
Gang
G
Liu
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
Ren-Xi
RX
Zhuo
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.|The Institute for Advanced Studies, Wuhan University, Wuhan, 430072, P. R. China.|Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Wuhan, 430068, P. R. China.
Xian-Zheng
XZ
Zhang
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D005260:Female; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D053685:Laser Therapy; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D000068936:Theranostic Nanomedicine / Q000379:methods*
D000970:Antineoplastic Agents; D006046:Gold; D004317:Doxorubicin
cancer therapy; drug delivery systems; gold nanorods; theranostics