In-vitro release of fragrant l-carvone from electrospun poly(ϵ-caprolactone)/wheat cellulose scaffold.
The release kinetics of l-carvone loaded from electrospun poly(ϵ-caprolactone) (PCL) and Wheat cellulose (WC) blend were studied. WC was extracted from wheat straw, a cost effective agricultural waste by the acid hydrolysis method. A homogeneous solution of PCL-WC (13:3wt%) was optimized to produce beadless electrospun PCL-WC blend nanofibers. Further, WC and the prepared electrospun PCL-WC blend fibers were systematically characterized by ATR-FTIR, SEM, XRD, TGA, DTGA, and DSC measurements. The hydrophilic character of the blend fibers was analysed using swelling tests and contact angle measurements. The loading efficiency of l-carvone into the electrospun PCL-WC blend fibers was evaluated to be ∼70%. The in-vitro release of l-carvone from PCL-WC blend fibers followed Korsmeyer-Peppas kinetic model indicating the diffusion mechanism and the maximum release of l-carvone was found to be ∼84% over a period of 30h. These results would offer the prepared PCL-WC blend as an ideal fibrous mesh for fragrant antimicrobial textile applications.
Department of Chemistry, Anna University, Chennai, Tamil Nadu 600025, India.
Manjula
M
Ramamoorthy
Department of Chemistry, Anna University, Chennai, Tamil Nadu 600025, India. Electronic address: sheeja@annauniv.edu.
Sheeja
S
Rajiv
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D002482:Cellulose / Q000737:chemistry*; D000081005:Cyclohexane Monoterpenes; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004560:Electricity; D006868:Hydrolysis; D007700:Kinetics; D039821:Monoterpenes / Q000737:chemistry* / Q000494:pharmacology; D057139:Nanofibers / Q000737:chemistry; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D014908:Triticum / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000081005:Cyclohexane Monoterpenes; D004337:Drug Carriers; D039821:Monoterpenes; D011091:Polyesters; C016240:polycaprolactone; C006923:carvone; D002482:Cellulose
Blend; Korsmeyer–Peppas model; Poly(ϵ-caprolactone); Release kinetics; Wheat cellulose; l-Carvone