Type 2 diabetes - Tuberculosis co-morbidity is associated with diminished circulating levels of IL-20 subfamily of cytokines.
IL-20 subfamily of cytokines play an important role in both host defense mechanisms and glucose metabolism. Since, the interaction between tuberculosis (TB) and diabetes (DM) involves both of the above processes, we examined the association of IL-20 subfamily of cytokines in TB-DM co-morbidity. We examined circulating plasma cytokine levels in individuals with active TB with (PTB-DM) or without (PTB) diabetes and also those with latent TB with (LTB-DM) or without (LTB) diabetes. PTB-DM is characterized by diminished circulating levels of IL-19, IL-20, IL-22 and IL-24 but increased levels of IL-10. Similarly, LTB-DM was also characterized by diminished circulating levels of IL-10, IL-19, IL-20 and IL-24 but increased levels of IL-22. Moreover, there was a significant negative correlation of IL-10, IL-19, IL-20, IL-22 and IL-24 levels with hemoglobin A1C (HbA1c) levels in both PTB and/or LTB individuals. Finally, PTB is characterized by diminished levels of IL-19, IL-20, IL-22 and IL-24 in comparison to LTB individuals. Our data reveal that coincident diabetes in either PTB or LTB is characterized by decreased production of the IL-20 subfamily of cytokines and suggest that these cytokines might play an important role in pathogenesis or protection.
National Institutes of Health-NIRT-International Center for Excellence in Research, National Institute for Research in Tuberculosis, Chetpet, Chennai 600031, India; National Institute for Research in Tuberculosis, Chennai, India.
Nathella Pavan
NP
Kumar
National Institute for Research in Tuberculosis, Chennai, India.
Vaithilingam V
VV
Banurekha
National Institute for Research in Tuberculosis, Chennai, India.
Dina
D
Nair
National Institute for Research in Tuberculosis, Chennai, India.
Paul
P
Kumaran
National Institute for Research in Tuberculosis, Chennai, India.
Chandra Kumar
CK
Dolla
National Institutes of Health-NIRT-International Center for Excellence in Research, National Institute for Research in Tuberculosis, Chetpet, Chennai 600031, India. Electronic address: sbabu@mail.nih.gov.
Subash
S
Babu
D000328:Adult; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D015536:Down-Regulation; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007194:India / Q000453:epidemiology; D007378:Interleukins / Q000097:blood*; D055985:Latent Tuberculosis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D055815:Young Adult
D015415:Biomarkers; D006442:Glycated Hemoglobin; D007378:Interleukins; C517652:hemoglobin A1c protein, human; C422042:interleukin 20
Bacterial; Cytokines; Diabetes; IL-10; IL-20 subfamily; Tuberculosis