Circulating lncRNAs associated with occurrence of colorectal cancer progression.
Screening for the potential biomarker of colorectal cancer (CRC) is necessary to improve the early detection. The aim of this study was to investigate the potential of circulating cell-free long non-coding RNAs (lncRNA) as biomarkers of CRC. In this study, we applied an lncRNA microarray to screen the potential biomarker for CRC with a multi-stage validation and risk score formula detection. We discovered three lncRNA, XLOC_006844, LOC152578 and XLOC_000303, which were up-regulated in CRC comparing with the cancer-free controls with the merged area under curve (AUC) in training set and validation set of 0.919 and 0.975. The three lncRNAs might be the potential biomarker for the tumorigenesis prediction of CRC in the future.
Department of Hepatobiliary Surgery, Binzhou Medical University Hospital 661 Second Huanghe Road, Binzhou 256603, China ; Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Jian
J
Shi
Department of Pediatrics, Binzhou Medical University Hospital 661 Second Huanghe Road, Binzhou 256603, China.
Xiaohua
X
Li
Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Fan
F
Zhang
Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Changxi
C
Zhang
Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Qinghai
Q
Guan
Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Xuefeng
X
Cao
Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Wentao
W
Zhu
Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Xingyuan
X
Zhang
Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Yu
Y
Cheng
Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Kun
K
Ou
Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Qiangpu
Q
Chen
Department of Hepatobiliary Surgery, Binzhou Medical University Hospital 661 Second Huanghe Road, Binzhou 256603, China.
Sanyuan
S
Hu
CRC; biomarker; high throughput; lncRNA; risk score function