Analysis of the correlation of CATSPER single nucleotide polymorphisms (SNPs) with idiopathic asthenospermia.
OBJECTIVE
Idiopathic asthenospermia is the most common type of male infertility. Although the mechanisms causing asthenospermia are complex, recent studies have indicated an important role of cation channel of sperm (CATSPER) gene downregulation or abnormality in the etiology of idiopathic asthenospermia.


METHODS
In the present study, 192 patients with idiopathic asthenospermia and 288 healthy controls were enrolled, and a flight mass spectrometry using Sequenom's MassArray biochip system was applied for genotyping 16 CATSPER gene SNPs reported in the human single nucleotide polymorphism (SNP) database.


RESULTS
Our results indicated a correlation between CATSPER1 SNPs and idiopathic asthenospermia. In particular, the exonal SNP rs1893316 in CATSPER1 significantly correlated with idiopathic asthenospermia risk and is a potential important factor in determining an individual's genetic susceptibility to idiopathic asthenospermia.


CONCLUSIONS
These finding will help to further elucidate the role of CATSPER1 in idiopathic asthenospermia pathogenesis.
Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.
Fangpeng
F
Shu
Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.
Xumin
X
Zhou
School of Biotechnology, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.
Fenxia
F
Li
Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.
Daojun
D
Lu
Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.
Bin
B
Lei
Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.
Qi
Q
Li
Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.
Yu
Y
Yang
School of Biotechnology, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. shirongphd@126.com.
Xuexi
X
Yang
Institute of Genetic Engineering, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. shirongphd@126.com.
Rong
R
Shi
Department of Urology, NanFang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China. shirongphd@126.com.
Xiangming
X
Mao
D000328:Adult; D044466:Asian People / Q000235:genetics; D053627:Asthenozoospermia / Q000235:genetics*; D015220:Calcium Channels / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013094:Spermatozoa / Q000378:metabolism
C438823:CATSPER1 protein, human; D015220:Calcium Channels
Cation channel of sperm (CATSPER); Idiopathic asthenospermia; Single nucleotide polymorphisms (SNPs)