CHD associated with syndromic diagnoses: peri-operative risk factors and early outcomes.
CHD is frequently associated with a genetic syndrome. These syndromes often present specific cardiovascular and non-cardiovascular co-morbidities that confer significant peri-operative risks affecting multiple organ systems. Although surgical outcomes have improved over time, these co-morbidities continue to contribute substantially to poor peri-operative mortality and morbidity outcomes. Peri-operative morbidity may have long-standing ramifications on neurodevelopment and overall health. Recognising the cardiovascular and non-cardiovascular risks associated with specific syndromic diagnoses will facilitate expectant management, early detection of clinical problems, and improved outcomes--for example, the development of syndrome-based protocols for peri-operative evaluation and prophylactic actions may improve outcomes for the more frequently encountered syndromes such as 22q11 deletion syndrome.
Heart Institute,Cincinnati Children's Hospital Medical Center,Cincinnati,Ohio,United States of America.
Benjamin J
BJ
Landis
Heart Institute,Cincinnati Children's Hospital Medical Center,Cincinnati,Ohio,United States of America.
David S
DS
Cooper
Heart Institute,Cincinnati Children's Hospital Medical Center,Cincinnati,Ohio,United States of America.
Robert B
RB
Hinton
D058165:22q11 Deletion Syndrome / Q000150:complications; D016738:Alagille Syndrome / Q000150:complications; D006330:Heart Defects, Congenital / Q000150:complications / Q000235:genetics / Q000601:surgery*; D006331:Heart Diseases / Q000150:complications / Q000151:congenital* / Q000235:genetics / Q000601:surgery*; D059446:Heterotaxy Syndrome / Q000150:complications; D006801:Humans; D007223:Infant; D008382:Marfan Syndrome / Q000150:complications; D009634:Noonan Syndrome / Q000150:complications; D012307:Risk Factors; D013577:Syndrome; D013997:Time Factors; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000150:complications; D018980:Williams Syndrome / Q000150:complications
CHD; genetic; syndrome