Neural stem cell transplantation promotes behavioral recovery in a photothrombosis stroke model.
Stem cell-based therapy provides a promising approach for treat stroke. Neural stem cells isolated from mice hippocampus possessing the capacity of differentiate into neurons and astrocytes both in vitro and vivo. Here, we investigated the capability of neural stem cell transplantation in photothrombosis stroke model. Nissl staining revealed that the cortical infarct significantly decreased by 16.32% (Vehicle: 27.93le: an mm(3), n=6, NSC: 23.37le: ai mm(3), n=6, P<0.05) in the NSC group compared with the vehicle. More over transplantation of neural stem cells significantly (P<0.01) improved neurological performance compared with vehicle. These results indicate that transplantation of neural stem cell is an effective therapy in ischemic stroke.
Department of Neurosurgery, Lanzhou University Second Hospital Lanzhou 730000, Gansu Province, China ; Lanzhou University Lanzhou 730000, Gansu Province, China.
Junning
J
Ma
Department of Neurosurgery, Lanzhou University Second Hospital Lanzhou 730000, Gansu Province, China ; Lanzhou University Lanzhou 730000, Gansu Province, China.
Junwei
J
Gao
Department of Neurosurgery, Lanzhou University Second Hospital Lanzhou 730000, Gansu Province, China ; Lanzhou University Lanzhou 730000, Gansu Province, China.
Boru
B
Hou
Department of Neurosurgery, Lanzhou University Second Hospital Lanzhou 730000, Gansu Province, China.
Jixing
J
Liu
Department of Neurosurgery, Lanzhou University Second Hospital Lanzhou 730000, Gansu Province, China.
Sihua
S
Chen
Department of Neurosurgery, Lanzhou University Second Hospital Lanzhou 730000, Gansu Province, China.
Guizhong
G
Yan
Department of Neurosurgery, Lanzhou University Second Hospital Lanzhou 730000, Gansu Province, China ; Lanzhou University Lanzhou 730000, Gansu Province, China.
Haijun
H
Ren
D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D051379:Mice; D058953:Neural Stem Cells / Q000637:transplantation*; D009474:Neurons / Q000378:metabolism; D020127:Recovery of Function; D033581:Stem Cell Transplantation / Q000379:methods*; D020521:Stroke / Q000150:complications / Q000473:pathology / Q000628:therapy
Neural stem cell; functional recovery; ischemic stroke; photothrombotic model; transplantation