Human umbilical cord blood stem cells and brain-derived neurotrophic factor for optic nerve injury: a biomechanical evaluation.
Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit models of optic nerve injury were established by a clamp. At 7 days after injury, the vitreous body received a one-time injection of 50 μg brain-derived neurotrophic factor or 1 × 10(6) human umbilical cord blood stem cells. After 30 days, the maximum load, maximum stress, maximum strain, elastic limit load, elastic limit stress, and elastic limit strain had clearly improved in rabbit models of optical nerve injury after treatment with brain-derived neurotrophic factor or human umbilical cord blood stem cells. The damage to the ultrastructure of the optic nerve had also been reduced. These findings suggest that human umbilical cord blood stem cells and brain-derived neurotrophic factor effectively repair the injured optical nerve, improve biomechanical properties, and contribute to the recovery after injury.
Department of Mechanics, PLA Air Force Aviation University, Changchun, Jilin Province, China.
Zhong-Jun
ZJ
Zhang
Mathematics School, Jilin University, Changchun, Jilin Province, China.
Ya-Jun
YJ
Li
Department of Mechanics, PLA Air Force Aviation University, Changchun, Jilin Province, China.
Xiao-Guang
XG
Liu
Department of Mechanics, PLA Air Force Aviation University, Changchun, Jilin Province, China.
Feng-Xiao
FX
Huang
Department of Mechanics, PLA Air Force Aviation University, Changchun, Jilin Province, China.
Tie-Jun
TJ
Liu
Department of Mechanics, PLA Air Force Aviation University, Changchun, Jilin Province, China.
Dong-Mei
DM
Jiang
Department of Ophthalmology, China-Japan Friendship Hospital, Jilin University, Changchun, Jilin Province, China.
Xue-Man
XM
Lv
Department of Pain, China-Japan Friendship Hospital, Jilin University, Changchun, Jilin Province, China.
Min
M
Luo
biomechanical properties; brain-derived neurotrophic factor; human umbilical cord blood stem cells; nerve regeneration; neural regeneration; optic nerve injury