NUT expression in primary lung tumours.
BACKGROUND
Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding occurrence in structures outside the midline. We investigated specimens from 519 surgically resected lung carcinomas and carcinoid tumours for the presence of NUT protein using immunohistochemistry. Normal testis and two previously confirmed NMCs served as positive controls.


RESULTS
All 483 evaluable cases (278 adenocarcinomas, 140 squamous cell carcinomas, 30 large cell carcinomas, 7 small cell carcinomas, 10 undifferentiated carcinomas and 18 carcinoids) were completely negative for expression of NUT protein.


CONCLUSIONS
NUT gene rearrangement does not seem to be relevant in primary pulmonary carcinomas or carcinoid tumours of the lung.
Department of Pathology, Oslo University Hospital, Radiumhospitalet 0310, Oslo, Norway. mlundive@ous-hf.no.|, Ullernchausseen 70, N-0310, Oslo, Norway. mlundive@ous-hf.no.
Marius
M
Lund-Iversen
Department of Pathology, Oslo University Hospital, Radiumhospitalet 0310, Oslo, Norway.
Krystyna Kotanska
KK
Grøholt
Department of Oncology, Oslo University Hospital, Radiumhospitalet 0310, Oslo, Norway.
Åslaug
Å
Helland
Department of Pathology, Oslo University Hospital, Radiumhospitalet 0310, Oslo, Norway.
Elin
E
Borgen
Department of Oncology, Oslo University Hospital, Radiumhospitalet 0310, Oslo, Norway.
Odd Terje
OT
Brustugun
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002276:Carcinoid Tumor / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D009687:Nuclear Proteins / Q000096:biosynthesis*; D015513:Oncogene Proteins / Q000096:biosynthesis*; D046888:Tissue Array Analysis
D014408:Biomarkers, Tumor; C000630260:NUTM1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins