Adaption by Rewiring Epigenetic Landscapes.
Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.
Department of Genetics and Yale Stem Cell Center, Yale University, New Haven, CT 06519, USA.
Yifei
Y
Liu
Department of Genetics and Yale Stem Cell Center, Yale University, New Haven, CT 06519, USA. Electronic address: andrew.xiao@yale.edu.
Andrew
A
Xiao
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D019175:DNA Methylation; D006657:Histones / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D020080:Tandem Repeat Sequences / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D006657:Histones; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D004265:DNA Helicases; D008239:Lysine