The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort.
Introduction. The common adiponutrin (PNPLA3) variant p.Ile148Met is associated with liver injury. Here, we investigate the association of this polymorphism with hepatic and metabolic traits in a pediatric cohort. Patients and Methods. The study cohort comprised 142 German children (age 5-9 years, 98 overweight, 19 children with NAFLD). Results. Overweight children presented with increased serum ALT (P = 0.001) and GGT (P < 0.001) activities. ALT activities differed significantly (P = 0.02) between carriers of different PNPLA3 genotypes in the entire study cohort, in normal weight children (P = 0.02) and in children younger than 7 years (P = 0.02). Carriers of the prosteatotic PNPLA3 genotype p.148Met/Met displayed higher ALT activities as compared to children with the frequent genotype p.148Ile/Ile (P = 0.01). The BMI was however a stronger predictor of ALT activities compared to the PNPLA3 genotype (P < 0.001 and P = 0.06, resp.). The variant was associated with increased serum glucose levels (P = 0.01) and HOMA index (P = 0.02) in carriers of the p.148Ile/Met genotype but did not affect other metabolic traits or the presence of NAFLD. Discussion. The frequent PNPLA3 variant p.Ile148Met is associated with serum ALT activities already at a young age.
Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany ; Laboratory of Metabolic Liver Diseases, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-091 Warsaw, Poland.
Marcin
M
Krawczyk
Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany ; Klinik für Innere Medizin II, Klinikum Mannheim, Universität Heidelberg, 68135 Mannheim, Germany.
Roman
R
Liebe
Department of Nutritional Medicine, Universität Hohenheim, 70599 Stuttgart, Germany.
Ina B
IB
Maier
Department of Nutritional Sciences, SD Model Systems of Molecular Nutrition, Friedrich-Schiller-Universität, 07743 Jena, Germany.
Anna Janina
AJ
Engstler
Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Frank
F
Lammert
Department of Nutritional Sciences, SD Model Systems of Molecular Nutrition, Friedrich-Schiller-Universität, 07743 Jena, Germany.
Ina
I
Bergheim