A novel four- and pseudo-five-component reaction: unexpected efficient one-pot synthesis of 4H-thiopyran derivatives.
A facile and convenient novel method is reported for the synthesis of substituted 4H-thiopyrans by reacting aldehydes, malononitrile, carbon disulfide, and primary amines at room temperature in the presence of triethylamine as a catalyst. This reaction affords the desired products in high purity and has advantages of excellent yields, simple work-up procedure, and short reaction time.
Department of Chemistry, Faculty of Science, Arak University, 38156-88349, Arak, Iran.
Akbar
A
Mobinikhaledi
Department of Chemistry, Faculty of Science, Arak University, 38156-88349, Arak, Iran. mbodaghi2007@yahoo.com.
Mohammad Ali
MA
Bodaghifard
Department of Chemistry, Faculty of Science, Arak University, 38156-88349, Arak, Iran.
Sajad
S
Asadbegi
D000447:Aldehydes / Q000737:chemistry; D002246:Carbon Disulfide / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D005021:Ethylamines / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature
D000447:Aldehydes; D005021:Ethylamines; D009570:Nitriles; D011714:Pyrans; D013438:Sulfhydryl Compounds; C522033:thiopyran; C000945:dicyanmethane; D002246:Carbon Disulfide; C016162:triethylamine
Isothiocyanate; MCR; Michael addition; Multicomponent reaction; One-pot reaction; Thiopyrans