Is central venous pressure still relevant in the contemporary era of liver resection?
BACKGROUND
Perioperative red blood cell transfusion (RBCT) remains common after liver resection and carries risk of increased morbidity and worse oncologic outcomes. We sought to assess the factors associated with perioperative RBCT after hepatectomy with a focus on intraoperative hemodynamics.


METHODS
We performed a retrospective review of our prospective hepatectomy database, supplemented by a review of anesthetic records of all patients undergoing hepatectomy with hemodynamic monitoring (arterial and central venous pressures [CVP]) from 2003-2012. Primary outcome was perioperative RBCT (during and within 30 d after surgery). After descriptive and univariate comparisons, multivariate analysis was conducted to identify factors associated with RBCT.


RESULTS
Of 851 hepatectomies, 530 had complete hemodynamic data and 30.2% (161 of 530) received RBCT. Among transfused patients, female gender (P = 0.01), preoperative anemia (P < 0.001), and major liver resection (P = 0.02) were more common. Mean estimated blood loss was 1.1 L higher (2.0 versus 0.9 L; P < 0.001) and operating time was 1.1 h longer (5.8 versus 4.7 h; P < 0.001) in transfused patients. Trends in intraoperative CVP differed significantly based on transfusion status (P = 0.007). Independent factors associated with RBCT included female gender (odds ratio [OR], 2.27; P = 0.01), preoperative anemia (OR, 2.38; P = 0.03), longer operative time (OR, 1.19 per hour; P = 0.03), and higher intraoperative CVP at 1 h during surgery (OR, 1.10 per mm Hg; P = 0.005).


CONCLUSIONS
Likelihood of RBCT is independently associated with female gender, preoperative anemia, longer operative time, and higher intraoperative CVP. Focus on management of preoperative anemia, operative efficiency, and low intraoperative CVP is needed to minimize the need for RBCTs.
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Eva See Wah
ES
Cheng
Division of General Surgery, Department of Surgery, ​Sunnybrook Health Sciences Centre - Odette Cancer Centre, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Julie
J
Hallet
Division of General Surgery, Department of Surgery, ​Sunnybrook Health Sciences Centre - Odette Cancer Centre, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Sherif S
SS
Hanna
Division of General Surgery, Department of Surgery, ​Sunnybrook Health Sciences Centre - Odette Cancer Centre, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Calvin H L
CH
Law
Division of General Surgery, Department of Surgery, ​Sunnybrook Health Sciences Centre - Odette Cancer Centre, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Natalie G
NG
Coburn
Department of Anesthesiology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Jordan
J
Tarshis
Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Yulia
Y
Lin
Division of General Surgery, Department of Surgery, ​Sunnybrook Health Sciences Centre - Odette Cancer Centre, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address: paul.karanicolas@sunnybrook.ca.
Paul J
PJ
Karanicolas
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016063:Blood Loss, Surgical / Q000517:prevention & control / Q000706:statistics & numerical data*; D001795:Blood Pressure Determination; D002496:Central Venous Pressure; D016208:Databases, Factual; D017707:Erythrocyte Transfusion / Q000706:statistics & numerical data*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007430:Intraoperative Care / Q000706:statistics & numerical data*; D007432:Intraoperative Period; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D011182:Postoperative Care / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
Anemia; Blood transfusion; Central venous pressure; Liver resection