Predictors of aortic pulse wave velocity in the elderly with severe aortic stenosis.
Predictors of aortic pulse wave velocity (AoPWV) were not previously studied in the elderly with severe aortic stenosis (AS). We aimed to compare the AoPWV in these patients with matched controls and to study the predictors of AoPWV in this population. We measured the AoPWV during cardiac catheterisation in 40 patients with severe AS and 20 matched controls. AoPWV in both groups was similar (p = 0.198) and lied within normal reference value for age in 68 % of elderly with severe AS. Central systolic blood pressure (SBP) (adjusted β = 0.45, p = 0.001) and glomerular filtration rate (GFR) (adjusted β = -0.29, p = 0.023) were the only independent predictors of AoPWV in AS group. Central SBP >140 mmHg was the best predictor of abnormal AoPWV (≥14.6 m/s) with 100 % sensitivity and 70 % specificity, p < 0.001.


CONCLUSIONS
AoPWV is not increased in the elderly with severe AS compared to controls, and lies within the reference value for age in the majority of these patients. Central SBP >140 mmHg best predicts abnormal AoPWV in the elderly with severe AS.
Department of Cardiology, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Hufelandstr. 55, 45147, Essen, Germany. karim.elchilali@uk-essen.de.
Karim
K
El-Chilali
Department of Cardiology, Cairo University Hospitals, Cairo University, Cairo, Egypt.
Heba
H
Farouk
Department of Cardiology, Assiut University Hospital, Assiut University, Asyut, Egypt.
Mohamed
M
Abdelhafez
Department of Cardiology, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Hufelandstr. 55, 45147, Essen, Germany.
Till
T
Neumann
Department of Cardiology, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Hufelandstr. 55, 45147, Essen, Germany.
Sultan
S
Alotaibi
Department of Cardiothoracic Surgery, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Essen, Germany.
Daniel
D
Wendt
Department of Cardiothoracic Surgery, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Essen, Germany.
Matthias
M
Thielmann
Department of Cardiothoracic Surgery, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Essen, Germany.
Heinz G
HG
Jakob
Department of Cardiology, Cairo University Hospitals, Cairo University, Cairo, Egypt.
Zeinab
Z
Ashour
Department of Cardiology, Cairo University Hospitals, Cairo University, Cairo, Egypt.
Khaled
K
Sorour
Department of Cardiology, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Hufelandstr. 55, 45147, Essen, Germany.
Philipp
P
Kahlert
Department of Cardiology, West German Heart and Vascular Center, Essen University Hospital, Duisburg-Essen University, Hufelandstr. 55, 45147, Essen, Germany.
Raimund
R
Erbel
D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000503:physiopathology*; D001024:Aortic Valve Stenosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D063177:Pulse Wave Analysis; D013599:Systole / Q000502:physiology
Aortic pulse wave velocity; Aortic stenosis; Elderly; Glomerular filtration rate; Systolic blood pressure