A Review on the Potential Role of Basement Membrane Laminin in the Pathogenesis of Psoriasis.
We have previously reviewed alterations to basement membrane laminin in psoriasis and how disruption of this layer could lead to at least some of the pathological changes observed. We here postulate that basement membrane laminin is the key antigen in driving psoriasis, inducing a T cell-mediated autoimmune response. For laminin to be considered as the key autoantigen in psoriasis, it would be reasonable to expect the following to be demonstrable: (1) that autoantigens are present in psoriatic inflammation; (2) that basement membrane laminin is perturbed in involved and uninvolved skin, and that some of the pathological changes associated with psoriasis could be predicted as a sequel to this; (3) that disruption of the basement membrane is among the earliest events in the evolution of psoriatic lesions; (4) that as streptococcal pharyngitis is the most clearly defined event to trigger or exacerbate psoriasis, then a T cell-mediated autoimmune response to laminin should be anticipated as a potential sequelae to streptococcal pharyngitis; (5) that T cells in psoriasis can be shown to react to peptides with homology to laminin; (6) that HLACw6, as the most closely related gene associated with psoriasis and which is involved in antigen expression, should be preferentially expressed within lesional psoriasis towards the basement membrane, together with other proximal associated immune activity; and (7) that there is some association between antilaminin pemphigoid, a humorally mediated autoimmune disease to skin basement membrane laminin, and psoriasis. We here review the data relevant to each of these requirements.
Department of Cutaneous Allergy, St John's Institute of Dermatology, Kings College, Guy's Hospital, London, UK.
J P
JP
McFadden
Faculty of Life Sciences, University of Manchester, Manchester, UK.
I
I
Kimber
D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007797:Laminin / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens; D007797:Laminin