Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation.
There is no clear consensus on optimal management of fetuses affected by familial hypertrophic cardiomyopathy (HCM). Intrauterine treatment of the condition has not been attempted in any standardized fashion. We report the case of a fetus treated by maternal propranolol during the third trimester after septal hypertrophy and diastolic dysfunction was diagnosed on fetal echocardiogram. The pregnancy went successfully to term, and fetal septal hypertrophy was noted to improve prior to delivery.
Department of Obstetrics and Gynecology, The University of Arizona, College of Medicine, 1501 N. Campbell Ave, 8th Floor, Tucson, AZ, 85724, USA. meghanhill@obgyn.arizona.edu.
Meghan G
http://orcid.org/0000-0002-4096-5339
MG
Hill
Department of Obstetrics and Gynecology, The University of Arizona, College of Medicine, 1501 N. Campbell Ave, 8th Floor, Tucson, AZ, 85724, USA.
Mehtab K
MK
Sekhon
Department of Obstetrics and Gynecology, The University of Arizona, College of Medicine, 1501 N. Campbell Ave, 8th Floor, Tucson, AZ, 85724, USA.
Kathryn L
KL
Reed
Department of Obstetrics and Gynecology, The University of Arizona, College of Medicine, 1501 N. Campbell Ave, 8th Floor, Tucson, AZ, 85724, USA.
Caroline F
CF
Anderson
Department of Obstetrics and Gynecology, The University of Arizona, College of Medicine, 1501 N. Campbell Ave, 8th Floor, Tucson, AZ, 85724, USA.
Nydia D
ND
Borjon
Department of Obstetrics and Gynecology, The University of Arizona, College of Medicine, 1501 N. Campbell Ave, 8th Floor, Tucson, AZ, 85724, USA.
Jil C
JC
Tardiff
Department of Obstetrics and Gynecology, The University of Arizona, College of Medicine, 1501 N. Campbell Ave, 8th Floor, Tucson, AZ, 85724, USA.
Brent J
BJ
Barber
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D024722:Cardiac Myosins / Q000235:genetics*; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000235:genetics*; D004452:Echocardiography; D005260:Female; D005333:Fetus / Q000002:abnormalities; D006801:Humans; D007231:Infant, Newborn; D009154:Mutation; D018995:Myosin Heavy Chains / Q000235:genetics*; D010375:Pedigree; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011433:Propranolol / Q000008:administration & dosage; D047929:Term Birth
D000319:Adrenergic beta-Antagonists; C501641:MYH7 protein, human; D011433:Propranolol; D024722:Cardiac Myosins; D018995:Myosin Heavy Chains
Beta myosin mutation; Fetal echocardiography; Fetal hypertrophic cardiomyopathy; Propranolol