Interference of Monovalent, Bivalent, and Trivalent Oral Poliovirus Vaccines on Monovalent Rotavirus Vaccine Immunogenicity in Rural Bangladesh.
BACKGROUND
Trivalent oral poliovirus vaccine (OPV) is known to interfere with monovalent rotavirus vaccine (RV1) immunogenicity. The interference caused by bivalent and monovalent OPV formulations, which will be increasingly used globally in coming years, has not been examined. We conducted a post hoc analysis to assess the effect of coadministration of different OPV formulations on RV1 immunogenicity.


METHODS
Healthy infants in Matlab, Bangladesh, were randomized to receive 3 doses of monovalent OPV type 1 or bivalent OPV types 1 and 3 at either 6, 8, and 10 or 6, 10, and 14 weeks of age or trivalent OPV at 6, 10, and 14 weeks of age. All infants received 2 doses of RV1 at about 6 and 10 weeks of age. Concomitant administration was defined as RV1 and OPV given on the same day; staggered administration as RV1 and OPV given ≥1 day apart. Rotavirus seroconversion was defined as a 4-fold rise in immunoglobulin A titer from before the first RV1 dose to ≥3 weeks after the second RV1 dose.


RESULTS
There were no significant differences in baseline RV1 immunogenicity among the 409 infants included in the final analysis. Infants who received RV1 and OPV concomitantly, regardless of OPV formulation, were less likely to seroconvert (47%; 95% confidence interval, 39%-54%) than those who received both vaccines staggered ≥1 day (63%; 57%-70%; P < .001). For staggered administration, we found no evidence that the interval between RV1 and OPV administration affected RV1 immunogenicity.


CONCLUSIONS
Coadministration of monovalent, bivalent, or trivalent OPV seems to lower RV1 immunogenicity.


BACKGROUND
NCT01633216.
Division of Viral Diseases.
Devy M
DM
Emperador
Division of Viral Diseases.
Daniel E
DE
Velasquez
Global Immunization Division, Centers for Diseases Control and Prevention, Atlanta, Georgia.
Concepcion F
CF
Estivariz
Division of Viral Diseases.
Ben
B
Lopman
Division of Viral Diseases.
Baoming
B
Jiang
Division of Viral Diseases.
Umesh
U
Parashar
Global Immunization Division, Centers for Diseases Control and Prevention, Atlanta, Georgia.
Abhijeet
A
Anand
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Khalequ
K
Zaman
D000914:Antibodies, Viral / Q000097:blood; D001459:Bangladesh; D004347:Drug Interactions; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007223:Infant; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage* / Q000276:immunology*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D012424:Rural Population; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D011055:Poliovirus Vaccine, Oral; C492457:RIX4414 vaccine; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated
OPV; Rotarix; oral polio vaccine; rotavirus vaccine; vaccine interference