Ocular delivery systems for topical application of anti-infective agents.
For the treatment of anterior eye segment infections using anti-infective agents, topical ocular application is the most convenient route of administration. However, topical delivery of anti-infective agents is associated with a number of problems and challenges owing to the unique structure of the eye and the physicochemical properties of these compounds. Topical ocular drug delivery systems can be classified into two forms: conventional and non-conventional. The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation resulting in low ocular bioavailability. Recently, attention has been focused on improving topical ocular delivery of anti-infective agents using advanced drug delivery systems. This review will focus on the challenges of efficient topical ocular delivery of anti-infective agents and will discuss the various types of delivery systems used to improve the treatment anterior segment infections.
a Faculty of Medical and Health Sciences , School of Pharmacy, The University of Auckland , Auckland , New Zealand and.
Linda
L
Duxfield
a Faculty of Medical and Health Sciences , School of Pharmacy, The University of Auckland , Auckland , New Zealand and.
Rubab
R
Sultana
a Faculty of Medical and Health Sciences , School of Pharmacy, The University of Auckland , Auckland , New Zealand and.
Ruokai
R
Wang
a Faculty of Medical and Health Sciences , School of Pharmacy, The University of Auckland , Auckland , New Zealand and.
Vanessa
V
Englebretsen
a Faculty of Medical and Health Sciences , School of Pharmacy, The University of Auckland , Auckland , New Zealand and.
Samantha
S
Deo
b Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, Faculty of Medical and Health Sciences, New Zealand National Eye Centre, The University of Auckland , Auckland , New Zealand.
Ilva D
ID
Rupenthal
a Faculty of Medical and Health Sciences , School of Pharmacy, The University of Auckland , Auckland , New Zealand and.
Raida
R
Al-Kassas
D060433:Administration, Ophthalmic; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001682:Biological Availability; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D005123:Eye / Q000033:anatomy & histology / Q000098:blood supply; D015817:Eye Infections / Q000188:drug therapy*; D006801:Humans; D009799:Ocular Physiological Phenomena; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000493:pharmacokinetics
D000891:Anti-Infective Agents, Local; D009883:Ophthalmic Solutions
Anti-infective agents; conventional ocular formulations; ocular delivery; particulate systems; polymers