Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates.
A series of novel sulfonamide substituted heteroleptic salan titanium(IV)-bis-chelates complexed to 2,6-pyridinedicarboxylic acid were synthesized, structurally characterized and evaluated for their anticancer activity against two human carcinoma cell lines. All cytotoxic complexes showed complete inhibition of cell growth at active concentration, two complexes based on pyrrolidine and azepane substituted sulfonamides displayed IC50 values below 1.7 μM and are more cytotoxic than cisplatin in both tested cell lines. The azepane substituted complex [L3Ti(dipic)] exhibited excellent activity with an IC50 value of 0.5 ± 0.1 μM in Hela S3 and 1.0 ± 0.1 μM in Hep G2.
Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstr. 10, D-78457 Konstanz, Germany. thomas.huhn@uni-konstanz.de.
Tiankun
T
Zhao
Martin
M
Grützke
Kathrin H
KH
Götz
Tetiana
T
Druzhenko
Thomas
T
Huhn
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002614:Chelating Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010848:Picolinic Acids; D011725:Pyridines / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
D000970:Antineoplastic Agents; D002614:Chelating Agents; D056831:Coordination Complexes; D010848:Picolinic Acids; D011725:Pyridines; D013449:Sulfonamides; D014025:Titanium; C004860:dipicolinic acid