Action mechanism of corticosteroids to aggravate Guillain-Barré syndrome.
Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical improvement. On 30(th) day after onset, there was significantly higher frequency of axonal degeneration in the corticosteroids-treated rabbits than saline-treated rabbits. Corticosteroids may reduce the scavengers that play a crucial role for nerve regeneration, thus delay the recovery of this disease.
Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, 272000, People's Republic of China.|Central Laboratory, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, 272000, People's Republic of China.
Yu-Zhong
YZ
Wang
Graduate School of Tianjin Medical University, Tianjin, 300071, People's Republic of China.
Hui
H
Lv
Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, 272000, People's Republic of China.
Qi-Guang
QG
Shi
Department of Spine Surgery, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, 272000, People's Republic of China.
Xu-Tao
XT
Fan
Department of Pathology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, 272000, People's Republic of China.
Lei
L
Li
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 117599, Singapore.
Anna Hiu
AH
Yi Wong
Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, 272000, People's Republic of China.
Yan-Lei
YL
Hao
Department of Immunology, Jining Medical College, Jining, Shandong Province, 272067, People's Republic of China.
Chuan-Ping
CP
Si
Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, 272000, People's Republic of China.
Cui-Lan
CL
Li
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 117599, Singapore.|Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117599, Singapore.|Brain and Mind Centre, University of Sydney, 94-100 Mallett St, Camperdown NSW 2050, Australia.
Nobuhiro
N
Yuki
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009046:Motor Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009416:Nerve Regeneration / Q000187:drug effects; D011817:Rabbits
D000305:Adrenal Cortex Hormones