Amorphous Aggregation of Amyloid Beta 1-40 Peptide in Confined Space.
The amorphous aggregation of Aβ1-40 peptide is addressed by using micromolding in capillaries. Both the morphology and the size of the aggregates are modulated by changing the contact angle of the sub-micrometric channel walls. Upon decreasing the hydrophilicity of the channels, the aggregates change their morphology from small aligned drops to discontinuous lines, thereby keeping their amorphous structure. Aβ1-40 fibrils are observed at high contact angles.
Scriba Nanotecnologie S. r. L., Via Corticella 183 -, 40128, Bologna, Italy.
Giulia
G
Foschi
Istituto per lo Studio dei Materiali Nanostrutturati - ISMN, Consiglio Nazionale delle Ricerche - CNR, Via P. Gobetti 101 -, 40129, Bologna, Italy). c.albonetti@bo.ismn.cnr.it.
Cristiano
C
Albonetti
Istituto di Microelettronica e Microsistemi - IMM, Consiglio Nazionale delle Ricerche - CNR, Via P. Gobetti 101 -, 40129, Bologna, Italy.
Fabiola
F
Liscio
Istituto di Microelettronica e Microsistemi - IMM, Consiglio Nazionale delle Ricerche - CNR, Via P. Gobetti 101 -, 40129, Bologna, Italy.
Silvia
S
Milita
Scriba Nanotecnologie S. r. L., Via Corticella 183 -, 40128, Bologna, Italy.
Pierpaolo
P
Greco
Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 183, I-41125, Modena, Italy.
Fabio
F
Biscarini
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D015415:Biomarkers / Q000134:cerebrospinal fluid; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D020527:Microscopy, Scanning Probe; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D004129:Dimethylpolysiloxanes; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); C013830:baysilon
Alzheimer's disease; amyloid; biotechnology; nanotechnology; scanning probe microscopy