Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens.
The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.
The Sir William Dunn School of Pathology, The University of Oxford, South Parks Road, Oxford OX13RE, UK. quentin.sattentau@path.ox.ac.uk.
Quentin J
QJ
Sattentau
HIV-1; envelope glycoproteins; neutralizing antibodies; trimer; vaccine