Evaluation Of Antioxidant Defense In Patients With Colorectal Carcinoma.
Cancers are among the most feared diseases of modern civilization. In Poland, colorectal cancer is one of the tumors with the worst prognosis. The ability to cure is primarily dependent on the stage of the disease at the time of diagnosis. The aim of the study was evaluate antioxidant response in patients with colorectal carcinoma.


METHODS
Twenty patients (14 men and 6 women) aged 61.9± 11.1 years with colorectal cancer were included in the study. Twenty healthy subjects (4 men and 16 women) aged 64 ± 15.3 years formed the control group. The erythrocyte activities of antioxidant enzymes, superoxide dismutase (SOD), and glutathione peroxidase (GPx), Results. A significant increase of GPx, and SOD (p < 0.05) were seen in patients compared to healthy controls.


CONCLUSIONS
The results indicate that the tested antioxidant enzyme activity of glutathione peroxidase and superoxide dismutase is increased in patients diagnosed with colorectal cancer compared to the control group.
Katarzyna
K
Malinowska
Michał
M
Mik
Łukasz
Ł
Dziki
Adam
A
Dziki
Ireneusz
I
Majsterek
D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000097:blood*; D002374:Catalase / Q000097:blood*; D015179:Colorectal Neoplasms / Q000503:physiopathology*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D013482:Superoxide Dismutase / Q000097:blood*
D000975:Antioxidants; D014408:Biomarkers, Tumor; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase