A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells.
Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.
State Key Laboratory of Virology &Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
Huan
H
He
State Key Laboratory of Virology &Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
Dong-Wei
DW
Li
State Key Laboratory of Virology &Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
Li-Yun
LY
Yang
State Key Laboratory of Virology &Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
Li
L
Fu
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China.
Xun-Jin
XJ
Zhu
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China.
Wai-Kwok
WK
Wong
State Key Laboratory of Virology &Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
Feng-Lei
FL
Jiang
State Key Laboratory of Virology &Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
Yi
Y
Liu
D000818:Animals; D000970:Antineoplastic Agents; D017209:Apoptosis / Q000187:drug effects; D001896:Boron Compounds; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media; D005456:Fluorescent Dyes; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods*; D008928:Mitochondria / Q000187:drug effects* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D011726:Pyridinium Compounds / Q000008:administration & dosage*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000970:Antineoplastic Agents; D001896:Boron Compounds; D003287:Contrast Media; D005456:Fluorescent Dyes; D007211:Indoles; D011726:Pyridinium Compounds; C471842:4-(2-(indol-3-yl)vinyl)-1-methylpyridinium