Mollenynes B-E from the marine sponge Spirastrella mollis. Band-selective heteronuclear single quantum coherence for discrimination of bromo-chloro regioisomerism in natural products.
Four new chlorobromohydrins, mollenynes B-E, were isolated from the marine sponge Spirastrella mollis collected from Hogsty Reef, Bahamas. Their structures were elucidated by integrated analysis of NMR, MS, and computational methods. A high-resolution band-selective HSQC experiment was developed to identify (13)C NMR signals in samples at the nanomole-scale that arise from Cl-substituted (13)C by exploiting the (35)Cl/(37)Cl isotope shift.
Department of Chemistry and Biochemistry, and ‡Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego , 9500 Gilman Drive, MC-0358, La Jolla, California 92093-0358, United States.
Xiao
X
Wang
Department of Chemistry and Biochemistry, and ‡Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego , 9500 Gilman Drive, MC-0358, La Jolla, California 92093-0358, United States.
Brendan M
BM
Duggan
Department of Chemistry and Biochemistry, and ‡Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego , 9500 Gilman Drive, MC-0358, La Jolla, California 92093-0358, United States.
Tadeusz F
TF
Molinski
D000818:Animals; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification*; D002728:Chlorohydrins / Q000737:chemistry* / Q000302:isolation & purification*; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D011789:Quantum Theory; D013237:Stereoisomerism
D001688:Biological Products; D002728:Chlorohydrins