Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer.
BACKGROUND
Several studies have evaluated histologic features of non-neoplastic breast parenchyma in patients with BRCA1/2 mutations, but the results are conflicting. The limited data suggest a much higher prevalence of high-risk precursor lesions in BRCA carriers. Therefore, we designed this study to compare the clinicopathological characteristics of peritumoral benign breast tissue in patients with and without deleterious BRCA mutations.


METHODS
Women with breast cancer (BC) who were referred for genetic counseling and underwent BRCA genetic testing in 2010 and 2011 were included in the study.


RESULTS
Of the six benign histological features analyzed in this study, only stromal fibrosis grade 2/3 was found to be statistically different, with more BRCA noncarriers having stromal fibrosis grade 2/3 than BRCA1/2 carriers (P = 0.04).


CONCLUSIONS
There is no significant association between mutation risk and the presence of benign histologic features of peritumoral breast parenchyma.
Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Soley
S
Bayraktar
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hongming
H
Qiu
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Diane
D
Liu
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yu
Y
Shen
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Angelica M
AM
Gutierrez-Barrera
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Banu K
BK
Arun
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Aysegul A
AA
Sahin
BRCA mutation; breast cancer; lobular sclerosis; lobular type; lobulitis; peritumoral breast parenchyma; stromal fibrosis