Fabrication of interconnected pore forming α-tricalcium phosphate foam granules cement.
Interconnected pore forming calcium phosphate cement is useful for the reconstruction of bone defects as well as scaffold fabrication in tissue engineering. In this study, interconnected pore forming calcium phosphate cement was fabricated using α-tricalcium phosphate (α-TCP) foam granules. When α-TCP foam granules were mixed with acidic calcium phosphate solution prepared from monocalcium phosphate monohydrate (MCPM) and phosphoric acid solution, brushite crystals were precipitated. These crystals bridged the α-TCP foam granules immediately upon mixing. As a result of the brushite bridge between the α-TCP foam granules, fully interconnected macroporous α-TCP was obtained. The amount of brushite precipitate and the mechanical strength of the set cement increased with acidic calcium phosphate concentration.
Faculty of Dental Science, Department of Biomaterials, Kyushu University, Fukuoka, Japan.
Khairul Anuar
KA
Shariff
Faculty of Dental Science, Department of Biomaterials, Kyushu University, Fukuoka, Japan tsuru@dent.kyushu-u.ac.jp.
Kanji
K
Tsuru
Faculty of Dental Science, Department of Biomaterials, Kyushu University, Fukuoka, Japan.
Kunio
K
Ishikawa
D001843:Bone Cements / Q000138:chemical synthesis*; D002130:Calcium Phosphates / Q000138:chemical synthesis*; D019245:Compressive Strength; D006244:Hardness; D008422:Materials Testing; D016062:Porosity; D013314:Stress, Mechanical; D013718:Tensile Strength; D054457:Tissue Scaffolds
D001843:Bone Cements; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate
Interconnected pore; brushite; calcium phosphate cement; foam granules; α-tricalcium phosphate