Role of mTOR in glioblastoma.
Mammalian target of rapamycin (mTOR), which is a member of the serine/threonine protein kinase family, is a protein complex that has a central role of cell growth and proliferation. mTOR emerges as a critical cell growth checkpoint on phosphoinositide 3-kinase (PI3K) signaling pathway. In this case mTOR has become an important therapeutic target for glioblastoma (GBM) that is one of the most deadly types of cancer. Various combination treatments including inhibition of mTOR may provide more significant results in the treatment of GBM. In addition to new mTOR targets, which may have a plant origin form, more potent mTOR inhibitors by utilizing the computational methodology may emerge as a hope for GBM therapy. In the future, a better understanding of the functional properties of mTORC2 with its potent effective inhibitors may help design more efficiently GBM treatment modalities.
Department of Medical Biology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.
Zekeriya
Z
Duzgun
Department of Medical Biology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.
Zuhal
Z
Eroglu
Department of Medical Biology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.
Cigir
C
Biray Avci
D000818:Animals; D005909:Glioblastoma / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D006801:Humans; D000076225:Mechanistic Target of Rapamycin Complex 2; D046912:Multiprotein Complexes / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D000076225:Mechanistic Target of Rapamycin Complex 2; D046912:Multiprotein Complexes; D009363:Neoplasm Proteins; D019869:Phosphatidylinositol 3-Kinases; D058570:TOR Serine-Threonine Kinases; C546842:MTOR protein, human
Brain tumors; Glioblastoma; PI3K/AKT/mTOR pathway; mTOR signaling