Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
OBJECTIVE
The aim of this study was to evaluate the relationship between serum sirtuin-1 (SIRT1) level and neutrophil-lymphocyte ratio (NLR) with hyperemesis gravidarum (HG).


METHODS
Overall, 90 patients who presented with pregnancy between August 2013 and November 2014 were included in the study. The patients were divided into two groups: patients with HG (n=45) and patients without HG (control group [C]; n=45). The patients with comorbid conditions other than pregnancy (disease or medication) were excluded. In all patients, demographic data including age, body mass index (BMI), gestational week, and smoking status were recorded. Blood samples were drawn for complete blood count and measurements of blood lipid, liver enzymes, serum SIRT1, and insulin levels. NLR was calculated from CBC.


RESULTS
No significant differences were detected in age, BMI, or GA between groups (P>0.05). Serum SIRT1 and NLR were found to be significantly higher in patients with HG compared with those in the control group (P=0.001 and 0.006, respectively).


CONCLUSIONS
In HG, both SIRT1 level and NLR increased. In HG, this occurred as a response to metabolic alterations and potential inflammation.
Emel Kiyak
EK
Caglayan
Yaprak
Y
Engin-Ustun
Ayşe Yesim
AY
Gocmen
Nagihan
N
Sarı
Levent
L
Seckin
Mustafa
M
Kara
Muhammed Fevzi
MF
Polat
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood* / Q000209:etiology; D007958:Leukocyte Count; D008214:Lymphocytes; D009504:Neutrophils; D011247:Pregnancy; D056564:Sirtuin 1 / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; C447939:SIRT1 protein, human; D056564:Sirtuin 1