Measuring couplings in crowded NMR spectra: pure shift NMR with multiplet analysis.
The PSYCHE method for pure shift NMR is exploited to generate 2D J spectra with full decoupling in one dimension and multiplet structure in the other, allowing spin-spin coupling constants to be measured even in very crowded spectra. Significant improvements over existing techniques are demonstrated for the hormones estradiol and androstenedione.
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK. Mohammadali.foroozandeh@manchester.ac.uk.
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M
Foroozandeh
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Adams
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P
Kiraly
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M
Nilsson
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Morris