Emerging trends in enzyme inhibition by multivalent nanoconstructs.
Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular targets, have been recently exploited for enzyme inhibition showing interesting properties such as improvement of inhibitory potency and selectivity. We review herein the recent results highlighting the potential of multivalent nanoconstructs for the inhibition of different enzymes, and the emerging trends in the generation and identification of multivalent clusters as enzyme inhibitors.
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, Université Montpellier, ENSCM, Ecole Nationale Supérieure de Chimie de Montpellier, 8 Rue de l'Ecole Normale, 34296 Montpellier cedex 5, France. jean-yves.winum@univ-montp2.fr sebastien.ulrich@enscm.fr.
Nasreddine
N
Kanfar
Eline
E
Bartolami
Renaud
R
Zelli
Alberto
A
Marra
Jean-Yves
JY
Winum
Sébastien
S
Ulrich
Pascal
P
Dumy
D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D002256:Carbonic Anhydrases / Q000737:chemistry / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry*
D002257:Carbonic Anhydrase Inhibitors; D004791:Enzyme Inhibitors; D006026:Glycoside Hydrolases; D002256:Carbonic Anhydrases