CAR-T Cell Therapy for Lymphoma.
Lymphomas arise from clonal expansions of B, T, or NK cells at different stages of differentiation. Because they occur in the immunocyte-rich lymphoid tissues, they are easily accessible to antibodies and cell-based immunotherapy. Expressing chimeric antigen receptors (CARs) on T cells is a means of combining the antigen-binding site of a monoclonal antibody with the activating machinery of a T cell, enabling antigen recognition independent of major histocompatibility complex restriction, while retaining the desirable antitumor properties of a T cell. Here, we discuss the basic design of CARs and their potential advantages and disadvantages over other immune therapies for lymphomas. We review current clinical trials in the field and consider strategies to improve the in vivo function and safety of immune cells expressing CARs. The ultimate driver of CAR development and implementation for lymphoma will be the demonstration of their ability to safely and cost-effectively cure these malignancies.
Center for Cell and Gene Therapy, Houston Methodist Hospital, Texas Children's Hospital, and Baylor College of Medicine, Houston, Texas 77030.|Dan L. Duncan Cancer Center.|Department of Medicine, and.
Carlos A
CA
Ramos
Center for Cell and Gene Therapy, Houston Methodist Hospital, Texas Children's Hospital, and Baylor College of Medicine, Houston, Texas 77030.|Dan L. Duncan Cancer Center.|Department of Medicine, and.|Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030; email: caramos@bcm.edu , hheslop@bcm.edu , mbrenner@bcm.edu.
Helen E
HE
Heslop
Center for Cell and Gene Therapy, Houston Methodist Hospital, Texas Children's Hospital, and Baylor College of Medicine, Houston, Texas 77030.|Dan L. Duncan Cancer Center.|Department of Medicine, and.|Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030; email: caramos@bcm.edu , hheslop@bcm.edu , mbrenner@bcm.edu.
Malcolm K
MK
Brenner
D000911:Antibodies, Monoclonal / Q000235:genetics / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology*; D000939:Epitopes; D018014:Gene Transfer Techniques; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000939:Epitopes; D011948:Receptors, Antigen, T-Cell
CD19; CD20; CD30; adoptive T cell therapy; immunotherapy; kappa light chain