The ABO Histo-Blood Group and AKI in Critically Ill Patients with Trauma or Sepsis.
OBJECTIVE
ABO blood types are determined by antigen modifications on glycoproteins and glycolipids and associated with altered plasma levels of inflammatory and endothelial injury markers implicated in AKI pathogenesis. We sought to determine the association of ABO blood types with AKI risk in critically ill patients with trauma or sepsis.


METHODS
We conducted two prospective cohort studies at an urban, academic, level I trauma center and tertiary referral center; 497 patients with trauma admitted to the surgical intensive care unit between 2005 and 2010 with an injury severity score >15 and 759 patients with severe sepsis admitted to the medical intensive care unit between 2008 and 2013 were followed for 6 days for the development of incident AKI. AKI was defined by Acute Kidney Injury Network creatinine and dialysis criteria.


RESULTS
Of 497 patients with trauma, 134 developed AKI (27%). In multivariable analysis, blood type A was associated with higher AKI risk relative to type O among patients of European descent (n=229; adjusted risk, 0.28 versus 0.14; risk difference, 0.14; 95% confidence interval, 0.03 to 0.24; P=0.02). Of 759 patients with sepsis, AKI developed in 326 (43%). Blood type A again conferred higher AKI risk relative to type O among patients of European descent (n=437; adjusted risk, 0.53 versus 0.40; risk difference, 0.14; 95% confidence interval, 0.04 to 0.23; P=0.01). Findings were similar when analysis was restricted to those patients who did not develop acute respiratory distress syndrome or were not transfused. We did not detect a significant association between blood type and AKI risk among individuals of African descent in either cohort.


CONCLUSIONS
Blood type A is independently associated with AKI risk in critically ill patients with trauma or severe sepsis of European descent, suggesting a role for ABO glycans in AKI susceptibility.
Divisions of Pulmonary, Allergy, and Critical Care and John.Reilly@uphs.upenn.edu.
John P
JP
Reilly
Divisions of Pulmonary, Allergy, and Critical Care and.
Brian J
BJ
Anderson
Divisions of Pulmonary, Allergy, and Critical Care and.
Nilam S
NS
Mangalmurti
Divisions of Pulmonary, Allergy, and Critical Care and.
Tam D
TD
Nguyen
Traumatology, Surgical Critical Care, and Emergency Surgery.
Daniel N
DN
Holena
Center for Clinical Epidemiology and Biostatistics, and.
Qufei
Q
Wu
Divisions of Pulmonary, Allergy, and Critical Care and.
Ethan T
ET
Nguyen
Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Muredach P
MP
Reilly
Divisions of Pulmonary, Allergy, and Critical Care and.
Paul N
PN
Lanken
Divisions of Pulmonary, Allergy, and Critical Care and Center for Clinical Epidemiology and Biostatistics, and.
Jason D
JD
Christie
Divisions of Pulmonary, Allergy, and Critical Care and.
Nuala J
NJ
Meyer
Divisions of Pulmonary, Allergy, and Critical Care and Center for Clinical Epidemiology and Biostatistics, and.
Michael G S
MG
Shashaty
D000017:ABO Blood-Group System / Q000097:blood*; D058186:Acute Kidney Injury / Q000097:blood* / Q000150:complications; D000328:Adult; D000368:Aged; D016638:Critical Illness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood* / Q000150:complications; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications; D055815:Young Adult
D000017:ABO Blood-Group System
ABO histoblood group system; AKI; critical illness; sepsis; trauma