Functioning in bipolar disorder with substance abuse/dependence in a community sample of young adults.
OBJECTIVE
To assess the functional impairment of young adults with bipolar disorder with substance abuse/dependence comorbidity.


METHODS
Cross-sectional study within a community sample. Bipolar Disorder was assessed by qualified psychologists using The Mini International Neuropsychiatric Interview - PLUS (MINI-PLUS). Substance abuse and dependence was assessed using the "Alcohol, Smoking and Substance Involvement Screening Test" (ASSIST). Functional impairment was assessed using the Functional Assessment Short Test (FAST).


RESULTS
The sample included 1259 young adults. The prevalence of Bipolar Disorder (BD) without Substance Abuse/Dependence (SAD) comorbidity was 5.9% (n=74), and the prevalence of bipolar disorder with substance abuse/dependence comorbidity was 1.4% (n=17). Both groups showed higher impairment in overall functioning, interpersonal relationship, and leisure time as compared to controls. In addition, BD+SAD showed higher impairment in the cognitive functioning domain of FAST.


CONCLUSIONS
A battery of neuropsychological tests was not performed.


CONCLUSIONS
Functional impairment is associated with BD, independently of substance abuse or dependence. In addition, BD+SAD present a more severe impairment in the cognitive domain of FAST as compared to controls.
Universidade Católica de Pelotas - Programa de Pós-Graduação em Saúde e Comportamento, Brazil; University of Texas Health Science Center at Houston - Department of Psychiatry, United States.
Taiane de Azevedo
Tde A
Cardoso
Universidade Católica de Pelotas - Programa de Pós-Graduação em Saúde e Comportamento, Brazil.
Thaise Campos
TC
Mondin
Universidade Católica de Pelotas - Programa de Pós-Graduação em Saúde e Comportamento, Brazil.
Luciano Dias de Mattos
LD
Souza
Universidade Católica de Pelotas - Programa de Pós-Graduação em Saúde e Comportamento, Brazil.
Ricardo Azevedo
RA
da Silva
Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre; Universidade Federal do Rio Grande do Sul - Programa de Pós-Graduação em Ciências Médicas: Psiquiatria, Brazil.
Pedro V S
PV
Magalhães
Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre; Universidade Federal do Rio Grande do Sul - Programa de Pós-Graduação em Ciências Médicas: Psiquiatria, Brazil.
Flavio
F
Kapczinski
Universidade Católica de Pelotas - Programa de Pós-Graduação em Saúde e Comportamento, Brazil; University of Texas Health Science Center at Houston - Department of Psychiatry, United States. Electronic address: karen.jansen@pq.cnpq.br.
Karen
K
Jansen
D000328:Adult; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000523:psychology*; D001938:Brazil / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D015995:Prevalence; D012919:Social Behavior; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000523:psychology*; D055815:Young Adult
Bipolar disorder; Comorbidity; Functional impairment; Illicit substance abuse/dependence; Young adult