Congenital Type III von Willebrand's disease unmasked by hypothyroidism in a Shetland sheepdog.
A 7-year-old, spayed female Shetland sheepdog had sudden onset of right-sided epistaxis. Diagnostic tests revealed Type III von Willebrand's disease and primary hypothyroidism leading to an acute hypothyroid crisis and acquired factor VIII (FVIII) deficiency. Levothyroxine therapy normalized the serum thyroxine and FVIII concentrations. The delayed onset of disease and the reversible FVIII deficiency that was corrected with levothyroxine therapy, support a role for hypothyroidism in the pathogenesis of this dog's sudden bleeding tendency as has been seen with hypothyroidism in humans.
Small Animal Clinical Sciences (Snead, Scuderi, Carr), Department of Pathology (Burgess), Western College of Veterinary Medicine, Saskatoon, Saskatchewan; Van Isle Veterinary Hospital, Courtenay, British Columbia (Bessey).
Margaret
M
Scuderi
Small Animal Clinical Sciences (Snead, Scuderi, Carr), Department of Pathology (Burgess), Western College of Veterinary Medicine, Saskatoon, Saskatchewan; Van Isle Veterinary Hospital, Courtenay, British Columbia (Bessey).
Lauren
L
Bessey
Small Animal Clinical Sciences (Snead, Scuderi, Carr), Department of Pathology (Burgess), Western College of Veterinary Medicine, Saskatoon, Saskatchewan; Van Isle Veterinary Hospital, Courtenay, British Columbia (Bessey).
Elisabeth
E
Snead
Small Animal Clinical Sciences (Snead, Scuderi, Carr), Department of Pathology (Burgess), Western College of Veterinary Medicine, Saskatoon, Saskatchewan; Van Isle Veterinary Hospital, Courtenay, British Columbia (Bessey).
Hilary
H
Burgess
Small Animal Clinical Sciences (Snead, Scuderi, Carr), Department of Pathology (Burgess), Western College of Veterinary Medicine, Saskatoon, Saskatchewan; Van Isle Veterinary Hospital, Courtenay, British Columbia (Bessey).
Anthony
A
Carr
D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D004285:Dogs; D004844:Epistaxis / Q000209:etiology / Q000662:veterinary; D005169:Factor VIII; D005260:Female; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D013974:Thyroxine / Q000627:therapeutic use; D056729:von Willebrand Disease, Type 3 / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*
D005169:Factor VIII; D013974:Thyroxine