Pierre Robin Sequence: A Familial, Clinical, and Pathoanatomical Record of an Affected Dachshund.
This study describes a spontaneous case of Pierre Robin sequence in a nonhuman animal species. A miniature dachshund with micrognathia developed glossoptosis, respiratory distress, dysphagia, temporomandibular ankylosis, and a misaligned upper jaw. The severity of this condition resulted in death by obstructive apnea at the age of 8 mo. Dogs with Pierre Robin sequence can provide further knowledge and a greater understanding of this abnormality, leading to better management of affected individuals and improvement of therapeutic methods.
From the Service of Medical Genetics (E.M.) and Laboratory of Pharmacology and Toxicology (C.P.), Faculty of Veterinary Medicine, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, Curitiba, Paraná, Brazil (E.M.); Clínica Veterinária Pet House, Curitiba, Paraná, Brazil (J.W.); and Laboratory of Pathology, Faculty of Veterinary Medicine, FEPAR, Curitiba, Paraná, Brazil (S.C.).
Enio
E
Moura
From the Service of Medical Genetics (E.M.) and Laboratory of Pharmacology and Toxicology (C.P.), Faculty of Veterinary Medicine, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, Curitiba, Paraná, Brazil (E.M.); Clínica Veterinária Pet House, Curitiba, Paraná, Brazil (J.W.); and Laboratory of Pathology, Faculty of Veterinary Medicine, FEPAR, Curitiba, Paraná, Brazil (S.C.).
José L
JL
Wagner
From the Service of Medical Genetics (E.M.) and Laboratory of Pharmacology and Toxicology (C.P.), Faculty of Veterinary Medicine, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, Curitiba, Paraná, Brazil (E.M.); Clínica Veterinária Pet House, Curitiba, Paraná, Brazil (J.W.); and Laboratory of Pathology, Faculty of Veterinary Medicine, FEPAR, Curitiba, Paraná, Brazil (S.C.).
Silvana M
SM
Cirio
From the Service of Medical Genetics (E.M.) and Laboratory of Pharmacology and Toxicology (C.P.), Faculty of Veterinary Medicine, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, Curitiba, Paraná, Brazil (E.M.); Clínica Veterinária Pet House, Curitiba, Paraná, Brazil (J.W.); and Laboratory of Pathology, Faculty of Veterinary Medicine, FEPAR, Curitiba, Paraná, Brazil (S.C.).
Cláudia T
CT
Pimpão
D000818:Animals; D004283:Dog Diseases / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D020022:Genetic Predisposition to Disease; D008297:Male; D008844:Micrognathism / Q000235:genetics / Q000473:pathology / Q000662:veterinary; D010375:Pedigree; D010855:Pierre Robin Syndrome / Q000473:pathology / Q000662:veterinary*