Human protein interaction networks across tissues and diseases.
Protein interaction networks are an important framework for studying protein function, cellular processes, and genotype-to-phenotype relationships. While our view of the human interaction network is constantly expanding, less is known about networks that form in biologically important contexts such as within distinct tissues or in disease conditions. Here we review efforts to characterize these networks and to harness them to gain insights into the molecular mechanisms underlying human disease.
Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev Beer-Sheva, Israel.
Esti
E
Yeger-Lotem
Blavatnik School of Computer Science, Tel Aviv University Tel Aviv, Israel.
Roded
R
Sharan
disease-specific network; gene expression; network perturbation; protein interaction network; tissue-specific network