Regulation of contractile ring formation and septation in Schizosaccharomyces pombe.
The fission yeast Schizosaccharomyces pombe has become a powerful model organism for cytokinesis studies, propelled by pioneering genetic screens in the 1980s and 1990s. S. pombe cells are rod-shaped and divide similarly to mammalian cells, utilizing a medially-placed actin-and myosin-based contractile ring. A cell wall division septum is deposited behind the constricting ring, forming the new ends of each daughter cell. Here we discuss recent advances in our understanding of the regulation of contractile ring formation through formin proteins and the role of the division septum in S. pombe cell division.
Department of Cell and Developmental Biology, PMB 407935, 465 21st Ave S., Vanderbilt University School of Medicine, Nashville, TN, United States.
Alaina H
AH
Willet
Department of Cell and Developmental Biology, PMB 407935, 465 21st Ave S., Vanderbilt University School of Medicine, Nashville, TN, United States.
Nathan A
NA
McDonald
Department of Cell and Developmental Biology, PMB 407935, 465 21st Ave S., Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address: kathy.gould@vanderbilt.edu.
Kathleen L
KL
Gould
D000199:Actins / Q000235:genetics / Q000502:physiology; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D002473:Cell Wall / Q000502:physiology; D048749:Cytokinesis / Q000235:genetics; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000502:physiology; D015966:Gene Expression Regulation, Fungal; D009218:Myosins / Q000235:genetics / Q000502:physiology; D051304:Profilins / Q000235:genetics / Q000502:physiology; D012568:Schizosaccharomyces / Q000166:cytology* / Q000235:genetics / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000502:physiology
D000199:Actins; C531994:Cdc12 protein, S pombe; D003598:Cytoskeletal Proteins; D051304:Profilins; D029702:Schizosaccharomyces pombe Proteins; D009218:Myosins