Potential therapeutic applications of plant toxin-ricin in cancer: challenges and advances.
Cancer is one of the most common devastating disease affecting millions of people per year worldwide. To fight against cancer, a number of natural plant compounds have been exploited by researchers to discover novel anti-cancer therapeutics with minimum or no side effects and plants have proved their usefulness in anti-cancer therapy in past few years. Ricin, a cytotoxic plant protein isolated from castor bean seeds, is a ribosome-inactivating protein which destroys the cells by inhibiting proteins synthesis. Ricin presents great potential as anti-cancer agent and exerts its anti-cancer activity by inducing apoptosis in cancer cells. In this review, we summarize the current information on anti-cancer properties of plant toxin ricin, its potential applications in cancer therapy, challenges associated with its use as therapeutic agent and the recent advances made to overcome these challenges. Nanotechnology could open the doors for quick development of ricin-based anti-cancer therapeutics. Conceivably, ricin may serve as a chemotherapeutic agent against cancer by utilizing nanocarriers for its targeted delivery to cancer cells.
Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, Delhi, 110021, India.|Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36688, USA.
Nikhil
N
Tyagi
Department of Plant and Molecular Biology, University of Delhi South Campus, Benito Juarez Road, Delhi, 110021, India.
Monika
M
Tyagi
Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, Delhi, 110021, India.
Manendra
M
Pachauri
Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, Delhi, 110021, India. pcghose@gmail.com.
Prahlad C
PC
Ghosh
D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000627:therapeutic use*; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy*; D012276:Ricin / Q000737:chemistry / Q000627:therapeutic use*
D008081:Liposomes; D012276:Ricin
Drug delivery; Immunotoxins; Liposomes; Plant toxin; RTA; Ricin