Single test isolated lupus anticoagulant positivity is associated with increased plasma levels of inflammatory markers and dyslipidemia.
OBJECTIVE
To investigate whether a single positive test for lupus anticoagulant (LA) is associated with levels of inflammatory markers and traditional cardiovascular risk factors, independent of autoimmune disease, thrombophilia and occurrence of other antiphospholipid antibodies.


METHODS
In a retrospective observational study we included persons referred for thrombophilia testing during 2011-2014. Persons with autoimmune disease, thrombophilia or presence of specific anti-phospholipid antibodies were excluded. Multivariate logistic regression analyses adjusted for age and sex was performed and odds ratios (ORs) with 95% confidence intervals (95% CI) calculated.


RESULTS
Of 381 individuals tested, 271 fulfilled the criteria, of whom 22 (8%) were LA positive and 249 (92%) LA negative. LA positivity was associated with higher body mass index (BMI) (OR 1.12, 95% CI: 1.03-1.23, p = 0.01); C-reactive protein (OR 1.08 95% CI:1.04-1.11, p < 0.001); fibrinogen (OR 1.51 95% CI: 1.27-1.78, p < 0.001); coagulation factor VIII (FVIII) (OR 1.73 95% CI: 1.01-2.96, p = 0.046), low high density lipoprotein (HDL) (OR 0.03 95% CI: 0.00-0.19, p < 0.001) and high triglyceride (OR 1.81 95% CI: 1.12-2.92, p = 0.02) compared with LA negative individuals.


CONCLUSIONS
This study shows that single test isolated LA positivity is associated with increased levels of inflammatory markers, low HDL cholesterol, elevated triglyceride and high BMI.
Department of Medicine, Svendborg Hospital, Odense University Hospital, Svendborg, Denmark.
S A
SA
Just
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
M
M
Nybo
Department of Rheumatology, Odense University Hospital, Odense, Denmark.
H
H
Laustrup
Department of Medicine, Svendborg Hospital, Odense University Hospital, Svendborg, Denmark.
Im Jensen
IJ
Hansen
Department of Rheumatology, Odense University Hospital, Odense, Denmark.
P
P
Junker
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark pernille.vinholt@rsyd.dk.
P Just
PJ
Vinholt
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D050171:Dyslipidemias / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis; D018836:Inflammation Mediators / Q000097:blood*; D008055:Lipids / Q000097:blood*; D016015:Logistic Models; D016682:Lupus Coagulation Inhibitor / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012042:Registries; D012189:Retrospective Studies
D015415:Biomarkers; D018836:Inflammation Mediators; D008055:Lipids; D016682:Lupus Coagulation Inhibitor
Antiphospholipid antibodies; dyslipidemia; inflammation; lupus anticoagulant