Infection with Toxin A-Negative, Toxin B-Negative, Binary Toxin-Positive Clostridium difficile in a Young Patient with Ulcerative Colitis.
Large clostridial toxin-negative, binary toxin-positive (A(-) B(-) CDT(+)) strains of Clostridium difficile are almost never associated with clinically significant C. difficile infection (CDI), possibly because such strains are not detected by most diagnostic methods. We report the isolation of an A(-) B(-) CDT(+) ribotype 033 (RT033) strain of C. difficile from a young patient with ulcerative colitis and severe diarrhea.
School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia.
Grace O
GO
Androga
Department of Microbiology, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.
Julie
J
Hart
School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia Department of Microbiology, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.
Niki F
NF
Foster
Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia.
Adrian
A
Charles
Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia School of Paediatrics and Child Health, The University of Western Australia, Crawley, Western Australia, Australia.
David
D
Forbes
School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia Department of Microbiology, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia thomas.riley@uwa.edu.au.
Thomas V
TV
Riley
D036002:ADP Ribose Transferases / Q000235:genetics* / Q000378:metabolism; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001315:Australia; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001427:Bacterial Toxins / Q000235:genetics*; D016360:Clostridioides difficile / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D003093:Colitis, Ulcerative / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy* / Q000382:microbiology; D004768:Enterotoxins / Q000235:genetics*; D005243:Feces / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012008:Recurrence
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile; D036002:ADP Ribose Transferases; C410164:actin-specific ADP-ribosyltransferase, Clostridium