Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS.
Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-L-phenylalanine (L-BPA). Biodistribution data revealed tumor-selective accumulation of (10)B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
Tooru
T
Andoh
Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-8558, Japan.
Takuya
T
Fujimoto
Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
Minoru
M
Suzuki
Section of Translational Research, Hyogo Cancer Center, Akashi 673-8558, Japan.
Tamotsu
T
Sudo
Radiation Medical Physics Laboratory, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
Yoshinori
Y
Sakurai
Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
Hiroki
H
Tanaka
Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-8558, Japan.
Ikuo
I
Fujita
Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-8558, Japan.
Naomasa
N
Fukase
Division of Pediatrics, University of Miyazaki, Miyazaki 889-1692, Japan.
Hiroshi
H
Moritake
Department of Pediatrics, Saiseikai Shigaken Hospital, Ritto 520-3046, Japan.
Tohru
T
Sugimoto
Department of Pathology, Hyogo Cancer Center, Akashi 673-8558, Japan.
Toshiko
T
Sakuma
Kitasuma Animal Hospital, Kobe 654-0131, Japan.
Hiroshi
H
Sasai
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Teruya
T
Kawamoto
Research Center of Boron Neutron Capture Therapy, Research Organization for the 21st Century, Osaka Prefecture University, Sakai 599-8531, Japan.
Mitsunori
M
Kirihata
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
Yoshinobu
Y
Fukumori
Department of Rehabilitation Science, Kobe University Graduate School of Health Science, Kobe 654-0142, Japan.
Toshihiro
T
Akisue
Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
Koji
K
Ono
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 650-8586, Japan. Electronic address: ichikawa@pharm.kobegakuin.ac.jp.
Hideki
H
Ichikawa
D000818:Animals; D016754:Boron Neutron Capture Therapy; D004195:Disease Models, Animal; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary*; D051379:Mice; D008807:Mice, Inbred BALB C; D018227:Sarcoma, Clear Cell / Q000532:radiotherapy*
Biodistribution; Boron neutron capture therapy (BNCT); Clear cell sarcoma (CCS); Lung metastasis; p-borono-L-phenylalanine (L-BPA)