Involvement of Interleukin 6 in Hepatitis B Viral Infection.
Hepatitis B is a major global health problem and a potentially life-threatening liver infection caused by hepatitis B virus (HBV). Many cytokines including interleukin 6 (IL-6) have been shown to be involved in the HBV infection process. IL-6 is a typical cytokine made up of 184 amino acids, and the gene is located in chromosome 7p21. For healthy people, serum IL-6 levels are usually too low to be detected. However, dysregulated synthesis of IL-6 has been discovered in chronic inflammatory diseases such as hepatitis B, Crohn's disease and rheumatoid arthritis. IL-6 also plays an important role in HBV replication and in the development of hepatitis B disease. This review aims to present the latest discoveries concerning the role of IL-6 in hepatitis B disease progression, and HBV entry and replication, and evaluate polymorphisms that are associated with the development of hepatitis B disease.
Caixia
C
Xia
Yanning
Y
Liu
Zhi
Z
Chen
Min
M
Zheng
D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D006509:Hepatitis B / Q000235:genetics* / Q000378:metabolism / Q000821:virology; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014779:Virus Replication
C508600:IL6 protein, human; D015850:Interleukin-6