[Antioxidant Activity of Salacia Plant (Salacia reticulata)].
Antioxidant activities of aqueous extracts prepared from powdered leaves and stems of Salacia reticulata, a Salacia plant that grows in Sri Lanka, were investigated. Lipid peroxide levels and some hepatic injury markers in plasma, liver and/or kidney of mice treated with ferric nitrilotriacetate (Fe-NTA) were increased as compared to those of control mice. Oral preadministration of extracts of Salacia leaves and stems at doses of 100, 200 and 400 mg/kg body weight prevented the elevations of lipid peroxides and injury markers in a dose-dependent manner. Decrease of antioxidant activity in plasma of mice treated with Fe-NTA was also prevented by administration of these extracts. In in vitro study, well-known polyphenol components exhibited antioxidant activities, but other effective components were also present in these extracts. The results of this investigation indicate that the extracts of leaves and stems of S. reticulata could be beneficial as health foods for the prevention of oxidative stress-related disorders.
Department of Chemistry and Biochemistry, National Institute of Technology, Numazu College.
Kyoji
K
Yoshino
Takashi
T
Kanetaka
Kunimasa
K
Koga
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D005290:Ferric Compounds; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008815:Mice, Inbred Strains; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D059808:Polyphenols / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D049918:Salacia / Q000737:chemistry*; D014867:Water
D000975:Antioxidants; D005290:Ferric Compounds; D008054:Lipid Peroxides; D010936:Plant Extracts; D059808:Polyphenols; D014867:Water; D009571:Nitrilotriacetic Acid; C020326:ferric nitrilotriacetate