Diffusion-weighted MRI findings in Sjögren's syndrome: a preliminary study.
BACKGROUND
Parotid glands diffusion-weighted imaging (DWI) in Sjögren's syndrome patients have provided conflicting results currently.


OBJECTIVE
To determine if parotid gland DWI using a small region of interest (ROI) can provide diagnosis and assess therapeutic efficacy in Sjögren's syndrome.


METHODS
Twenty-three women with Sjögren's syndrome, five with dry mouth who did not meet diagnostic criteria for Sjögren's syndrome, and 11 healthy volunteers (controls) were evaluated with DWI. All participants received routine T1-weighted (T1W) imaging and T2-weighted (T2W) fat-suppressed imaging, and DWI. The SI ratios (SIRs) and ADC ratios (ADCRs) for parotid gland/spinal cord were then calculated. Approximately 8-10 round ROIs measuring approximately 5 mm(2) were placed on each lobe of the parotid gland, and the signal intensity (SI) was measured while avoiding fat, ducts, and blood vessels. A ROI encompassing the entire lobe of the parotid gland was also used to measure SI.


RESULTS
Using 5 mm(2) ROIs significantly higher DWI SIRs were noted in participants with Sjögren's syndrome compared with either participants with dry mouth without Sjögren's syndrome or healthy volunteers (all, P <0.001). The difference was not related to the presence of fat. No differences were noted when the larger ROI was used. In addition, parotid gland from untreated Sjögren's participants showed significantly higher SIRs compared with those from treated participants (P = 0.015).


CONCLUSIONS
A small ROI DWI can provide morphological and functional information on the parotid gland in Sjögren's syndrome patients, and can aid in the diagnosis and evaluation of therapeutic efficacy.
Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China.
Changwei
C
Ding
Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China.
Xiaofei
X
Xing
Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China guo_qiyong@126.com.
Qiyong
Q
Guo
Departments of Rheumatology and Immunology, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, PR China.
Dongwu
D
Liu
Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China.
Yun
Y
Guo
Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China.
Huadong
H
Cui
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000000981:diagnostic imaging*
Sjögren’s syndrome; diffusion-weighted imaging (DWI); magnetic resonance imaging (MRI); parotid gland