The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings.
In recent years, the impact of environmental exposure to chemicals and their immunological effects, including the development of allergy, has been a topic of great interest. Epidemiologic studies indicate that exposure to endocrine-disrupting chemicals produced in high volumes, including bisphenol A (BPA) and phthalates, is ubiquitous. The links between their exposure and the development of allergy, asthma, and immune dysfunction have been studied in vitro, in vivo, and through human cohort studies. The purpose of this review is to examine the current body of research and to highlight deficits and strengths of current findings. Emerging science indicates that deleterious immunologic changes, including increased propensity to develop wheeze, allergy, and asthma after dietary and inhalation exposure to these chemicals, may be occurring.
Department of Medicine, Columbia University Medical Center, MH 6C-12, New York, NY, 10032, USA. lbr2129@cumc.columbia.edu.
Lacey
L
Robinson
Department of Medicine, Columbia University Medical Center, MH 6C-12, New York, NY, 10032, USA. rlm14@cumc.columbia.edu.|Department of Pediatrics, Columbia University Medical Center, New York, NY, USA. rlm14@cumc.columbia.edu.|Department of Environmental Health Sciences, Columbia University Medical Center, New York, NY, USA. rlm14@cumc.columbia.edu.|Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, PH8E-101B, New York, NY, 10032, USA. rlm14@cumc.columbia.edu.
Rachel
R
Miller
D000818:Animals; D001249:Asthma / Q000276:immunology*; D001559:Benzhydryl Compounds / Q000009:adverse effects*; D052244:Endocrine Disruptors / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D055633:Immune System Phenomena / Q000187:drug effects*; D023421:Models, Animal; D010636:Phenols / Q000009:adverse effects*; D010795:Phthalic Acids / Q000009:adverse effects*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; D010795:Phthalic Acids; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds
Allergy; Asthma; Bisphenol A; Immunotoxicity; Phthalates; Wheeze