COMPARATIVE STUDY OF GROWTH INHIBITORY PROTEIN COMPLEX DERIVED FROM DIFFERENT FORMS OF CHILDREN HEMANGIOMA.
The comparative analysis of the thermostable protein complexes obtained from the capillary and the cavernous hemangioma was carried out. It is shown that the active component (with low molecular weight 12-14 kD) is in minor content in the complexes obtained from capillary, as well as from the cavernous hemangioma. The effect of protein complexes from cavernous hemangiomas on proliferation of the brain and pancreatic cells in growing rats was studied. It was established that the thermostable protein complex from cavernous hemangiomas does not have the ability to inhibit the proliferation of heterotypic cells due to the minor content of the active ingredient in protein complexes.
Tbilisi State Medical University, Department of Padiatric Maxillofacial Surgery; G. Zhvania Academic Clinic of Pediatry, Iv. Javakhishvili Tbilisi State University, Department of Biology, Georgia.
Z
Z
Vadachkoria
Tbilisi State Medical University, Department of Padiatric Maxillofacial Surgery; G. Zhvania Academic Clinic of Pediatry, Iv. Javakhishvili Tbilisi State University, Department of Biology, Georgia.
L
L
Dzidziguri
Tbilisi State Medical University, Department of Padiatric Maxillofacial Surgery; G. Zhvania Academic Clinic of Pediatry, Iv. Javakhishvili Tbilisi State University, Department of Biology, Georgia.
E
E
Bakuradze
Tbilisi State Medical University, Department of Padiatric Maxillofacial Surgery; G. Zhvania Academic Clinic of Pediatry, Iv. Javakhishvili Tbilisi State University, Department of Biology, Georgia.
I
I
Modebadze
Tbilisi State Medical University, Department of Padiatric Maxillofacial Surgery; G. Zhvania Academic Clinic of Pediatry, Iv. Javakhishvili Tbilisi State University, Department of Biology, Georgia.
N
N
Oganezovi
Tbilisi State Medical University, Department of Padiatric Maxillofacial Surgery; G. Zhvania Academic Clinic of Pediatry, Iv. Javakhishvili Tbilisi State University, Department of Biology, Georgia.
M
M
Mikadze
Tbilisi State Medical University, Department of Padiatric Maxillofacial Surgery; G. Zhvania Academic Clinic of Pediatry, Iv. Javakhishvili Tbilisi State University, Department of Biology, Georgia.
D
D
Dzidziguri
D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation; D002648:Child; D006392:Hemangioma, Cavernous / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008565:Membrane Proteins / Q000008:administration & dosage / Q000378:metabolism*; D010179:Pancreas / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D051381:Rats
D008565:Membrane Proteins; C031717:growth inhibitory proteins