A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomography.
BACKGROUND
Optical coherence tomography offers a potential biomarker tool in Parkinson's disease (PD). A mathematical model quantifying symmetry, breadth, and depth of the fovea was applied.


METHODS
Nintey-six subjects (72 PD and 24 healthy controls) were included in the study. Macular scans of each eye were obtained on two different optical coherence tomography devices: Cirrus and RTVue.


RESULTS
The variables corresponding to the cardinal gradients of the fovea were the most sensitive indicators of PD for both devices. Principal component analysis distinguished 65% of PD patients from controls on Cirrus, 57% on RTVue.


CONCLUSIONS
Parkinson's disease shallows the superior/inferior and to a lesser degree nasal-temporal foveal slope. The symmetry, breadth, and depth model fits optical coherence tomography data derived from two different devices, and it is proposed as a diagnostic tool in PD.
Scarsdale, New York, USA.|SUNY College of Optometry, New York, New York, USA.
Samantha
S
Slotnick
New York University, School of Engineering, Brooklyn, New York, USA.
Yin
Y
Ding
SUNY Downstate Medical Center, Department of Neurology, Brooklyn, New York, USA.
Sofya
S
Glazman
Carl Zeiss-Meditec, Inc, Dublin, California, USA.
Mary
M
Durbin
Medstar Union Memorial Hospital, Department of Medicine, Baltimore, Maryland, USA.
Shahnaz
S
Miri
New York University, School of Engineering, Brooklyn, New York, USA.
Ivan
I
Selesnick
SUNY College of Optometry, New York, New York, USA.
Jerome
J
Sherman
SUNY Downstate Medical Center, Department of Neurology, Brooklyn, New York, USA.|SUNY Downstate Medical Center, Department of Ophthalmology, Brooklyn, New York, USA.|SUNY Eye Institute, Syracuse, New York, USA.
Ivan
I
Bodis-Wollner
D000368:Aged; D015415:Biomarkers; D003430:Cross-Sectional Studies; D005260:Female; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology*; D025341:Principal Component Analysis; D012160:Retina / Q000473:pathology*; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence
D015415:Biomarkers
Parkinson's disease; SBD model; foveal pit; optical coherence tomography; principal component analysis