Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation.
The cellular localisation and binding specificity of two NMDAR-targeted near-IR imaging probes has been examined by microscopy, followed by exemplification of MSOT to monitor simulated glutamate bursts in cellulo and a preliminary study in mice observing the signal in the brain.
Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK. david.parker@durham.ac.uk.
Neil
N
Sim
Sven
S
Gottschalk
Robert
R
Pal
Martina
M
Delbianco
Oleksiy
O
Degtyaruk
Daniel
D
Razansky
Gil G
GG
Westmeyer
Vasilis
V
Ntziachristos
David
D
Parker
Anurag
A
Mishra
D000818:Animals; D002460:Cell Line; D056831:Coordination Complexes / Q000737:chemistry; D005063:Europium / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D018698:Glutamic Acid / Q000032:analysis*; D007211:Indoles / Q000737:chemistry*; D007259:Infrared Rays; D051379:Mice; D061088:Photoacoustic Techniques; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis*; D014054:Tomography
D056831:Coordination Complexes; D005456:Fluorescent Dyes; D007211:Indoles; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D005063:Europium