Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors.
Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instable in vivo. Therefore, the search of excellent carriers to enhance sustained release of growth factors in vivo has become an area of intense research interest. The development of controlled-release systems that protect the recombinant growth factors from enzymatic degradation and provide sustained delivery at the injury site during healing should enhance the growth factor's application in tissue regeneration. Thus, this study reviews current research on commonly used carriers for sustained release of growth factors and their sustained release effects for preservation of their bioactivity and their accomplishment in tissue engineering approaches.
School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China ; Molecular Pharmacology Research Center, Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Hai-yang
HY
Zhao
Molecular Pharmacology Research Center, Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Jiang
J
Wu
Molecular Pharmacology Research Center, Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Jing-jing
JJ
Zhu
Molecular Pharmacology Research Center, Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Ze-cong
ZC
Xiao
Molecular Pharmacology Research Center, Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Chao-chao
CC
He
Molecular Pharmacology Research Center, Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Hong-xue
HX
Shi
School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China ; Molecular Pharmacology Research Center, Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Xiao-kun
XK
Li
School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China.
Shu-lin
SL
Yang
School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China ; Molecular Pharmacology Research Center, Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Jian
J
Xiao
D000818:Animals; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000627:therapeutic use; D004343:Drug Implants / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000627:therapeutic use; D012038:Regeneration / Q000187:drug effects*; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*
D003692:Delayed-Action Preparations; D004343:Drug Implants; D036341:Intercellular Signaling Peptides and Proteins