Introduction to thematic series: protein interactions, structures, and networks.
Protein interactions are fundamental to the proper functioning of cells, and aberrant formation or regulation of protein interactions is at the heart of many diseases, including cancer. The advancement of methods to study the identity, function, and regulation of protein complexes makes possible the understanding of how those complexes malfunction in human diseases. New methodologies in mass spectrometry, microscopy, and protein structural analysis are rapidly advancing the amount and quality of the data, as well as the level of detail that can be obtained from experiments. With this progress, the questions that can be addressed and the biological landscape are changing. This series of minireviews highlights methodological advances and how they have been applied in novel ways to explore the function and regulation of pathways and dynamic networks in cells.
From the Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 and appellae@mail.nih.gov.
Ettore
E
Appella
From the Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 and.
Lisa M Miller
LM
Jenkins
the Department of Biochemistry, School of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
F Peter
FP
Guengerich
D000818:Animals; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D046912:Multiprotein Complexes
DNA mismatch repair; T cell; amyloid; interferon; protein cross-linking; ubiquitin