Stem Cells in Teeth and Craniofacial Bones.
Stem cells are remarkable, and stem cell-based tissue engineering is an emerging field of biomedical science aiming to restore damaged tissue or organs. In dentistry and reconstructive facial surgery, it is of great interest to restore lost teeth or craniofacial bone defects using stem cell-mediated therapy. In the craniofacial region, various stem cell populations have been identified with regeneration potential. In this review, we provide an overview of the current knowledge concerning the various types of tooth- and craniofacial bone-related stem cells and discuss their in vivo identities and regulating mechanisms.
Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.
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H
Zhao
Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA huzhao@usc.edu ychai@usc.edu.
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Y
Chai
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D005147:Facial Bones / Q000166:cytology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000502:physiology; D012886:Skull / Q000166:cytology*; D013234:Stem Cells / Q000502:physiology*; D014070:Tooth / Q000166:cytology*
Gli1 protein; hedgehogs; mesenchymal stromal cells; neural crest; skull; stem cell niche