Metal-Free Catalytic Approach for Allylic C-H Amination Using N-Heterocycles via sp(3) C-H Bond Activation.
A versatile metal-free synthesis of allylic N-heterocycles has been developed using a TBAI/TBHP oxidation system. This general protocol could be applied for the C-N bond formation of electron-deficient phthalimides, imidazoles, triazoles, and sulfonamides with cyclic and acylic olefins. The practical use of the method is demonstrated by the amidation of functionalized biologically active substrates.
School of Chemistry & Chemical Engineering, Nanjing University , Nanjing 210093, China.
Jinwei
J
Sun
School of Chemistry & Chemical Engineering, Nanjing University , Nanjing 210093, China.
Yi
Y
Wang
School of Chemistry & Chemical Engineering, Nanjing University , Nanjing 210093, China.
Yi
Y
Pan