Mechanisms of Memory T Cell Activation and Effective Immunity.
Effective immunization induces the development of populations of robust effector lymphocytes specific for the immunizing antigens. Amongst them are cytotoxic/CD8(+)T lymphocytes, which few will further differentiate into long-lived memory cells persisting in the host and exhibiting improved functional characteristics. The current model is that such memory cells can confer rapid host protection upon cognate antigen-mediated activation and direct killing of infected cells. In this chapter, we discuss work from our group and others that highlight the contribution of inflammatory cytokines to memory CD8(+) T cell activation and of cytolysis-independent mechanisms of host protection.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA, gregoire.lauvau@einstein.yu.edu.
Grégoire
G
Lauvau
Saïdi M'Homa
SM
Soudja
D056704:Adaptive Immunity; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D000950:Antigens, Ly / Q000235:genetics / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D015415:Biomarkers / Q000378:metabolism; D039521:CD11c Antigen / Q000235:genetics / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D006801:Humans; D007114:Immunization; D007156:Immunologic Memory; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
D000942:Antigens, Bacterial; D000950:Antigens, Ly; D015415:Biomarkers; D039521:CD11c Antigen; D016207:Cytokines; C494192:Ly-6C antigen, mouse