Spontaneous Regression of Methotrexate-related Lymphoproliferative Disorder with T-cell Large Granular Lymphocytosis.
Spontaneous regression of methotrexate-related lymphoproliferative disorders (MTX-LPDs) occurs in some patients after withdrawal of MTX. However, the mechanisms by which MTX withdrawal contributes to the spontaneous regression of MTX-LPDs have not been fully elucidated. We herein show that spontaneous regression of MTX-LPDs is associated with the development of significant and transient T-cell large granular lymphocyte (T-LGL) lymphocytosis induced by MTX withdrawal. Since T-LGLs show strong cytotoxicity, their expansion may contribute to the spontaneous regression of lymphoma. Therefore, the development of T-LGL lymphocytosis maybe associated with a favorable prognosis in MTX-LPD patients.
Department of Internal Medicine, Karatsu Red Cross Hospital, Japan.
Hiroshi
H
Ureshino
Chiho
C
Kadota
Kazuya
K
Kurogi
Masaharu
M
Miyahara
Shinya
S
Kimura
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008218:Lymphocytosis / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology*; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D011379:Prognosis; D012075:Remission, Spontaneous; D013601:T-Lymphocytes / Q000473:pathology
D007166:Immunosuppressive Agents; D008727:Methotrexate