FLOT-2 is an independent prognostic marker in oral squamous cell carcinoma.
Flotillin-2 (Flot-2) is an important component of cellular membrane, which involves in various cellular processes and recent studies have revealed that Flot-2 played important roles in cancer progression. The expression and prognostic impact of Flot-2 in oral squamous cell carcinoma (OSCC) have not been well studied. So, a tissue microarray (TMA) based on immunohistochemical analysis of surgical resection of tumor tissues of 78 cases of OSCC patients and 27 cases of adjacent non-cancerous squamous epithelium tissues was conducted. This study focused on detecting Flot-2 expression and analyzing its prognostic impact on OSCC. The result showed that the positive percentage of Flot-2 expression in OSCC (74.4%, 58/78) was significantly higher than that in adjacent non-cancerous squamous epithelium tissues (25.9%, 7/27) (P<0.001). Additionally, the positive expression of Flot-2 in OSCC patients with a history of alcohol consumption was significantly higher than those nonusers (P=0.027). Both univariate and multivariate survival analysis indicated that increased expression Flot-2 protein was significantly correlated inversely with overall survival rates in OSCC patients (P=0.046, P=0.002). Taken together, positive expression of Flot-2 protein may be an independent biomarker for poor prognosis in OSCC.
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Qiuyuan
Q
Wen
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Mohannad Ma
MM
Alnemah
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Jiadi
J
Luo
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Weiyuan
W
Wang
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Shuzhou
S
Chu
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Lingjiao
L
Chen
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Jiao
J
Li
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Lina
L
Xu
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Meirong
M
Li
Department of Pathology, Xiangya School of Medicine, Central South University Hunan, China.
Jianhua
J
Zhou
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
Songqing
S
Fan
D000428:Alcohol Drinking / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016009:Chi-Square Distribution; D005260:Female; D006258:Head and Neck Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D000077195:Squamous Cell Carcinoma of Head and Neck; D046888:Tissue Array Analysis; D015854:Up-Regulation
D014408:Biomarkers, Tumor; D008565:Membrane Proteins; C106354:flotillins
Oral squamous cell carcinoma (OSCC); biomarker; flotillin-2 (flot-2); immunohistochemistry; prognosis