Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing.
This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates. The synthesized nitric oxide-releasing polymer was incorporated into the PEG-based ointment which not only facilitated nitric oxide release in a slow manner, but also served as a moisturizer to enhance the wound healing. As compared to control groups, the nitric oxide-releasing ointment showed the accelerated wound closure with enhanced re-epithelialization, collagen deposition, and blood vessel formation in vivo. Therefore, this nitric oxide-based ointment presents the promising potential for the efficient strategy to heal the cutaneous wound.
Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
Youngnam
Y
Kang
Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea.
Jihoon
J
Kim
Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea; Department of Chemistry Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
Yeong Mi
YM
Lee
Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
Sooseok
S
Im
School of Integrative Engineering, Chung-Ang University, Seoul 156-75l, Republic of Korea.
Hansoo
H
Park
Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea; Department of Chemistry Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea. Electronic address: wjkim@postech.ac.kr.
Won Jong
WJ
Kim
D000279:Administration, Cutaneous; D000818:Animals; D001391:Azo Compounds / Q000008:administration & dosage* / Q000138:chemical synthesis; D002626:Chemistry, Pharmaceutical; D003094:Collagen / Q000378:metabolism; D051379:Mice; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000008:administration & dosage* / Q000138:chemical synthesis; D009824:Ointments; D020442:Poloxamer / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000138:chemical synthesis; D011092:Polyethylene Glycols / Q000737:chemistry; D011094:Polyethyleneimine / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000138:chemical synthesis; D062326:Re-Epithelialization / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D001391:Azo Compounds; D020030:Nitric Oxide Donors; D009824:Ointments; C452539:diazeniumdiolate; D020442:Poloxamer; D009569:Nitric Oxide; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D003094:Collagen
N-diazeniumdiolate; Nitric oxide; Ointment; Wound healing