Control of Mesh Size and Modulus by Kinetically Dependent Cross-Linking in Hydrogels.
Kinetically controlled cross-linking processes produce mechanically distinguishable hydrogels using identical precursor chemistry. The oxime ligation demonstrates tunable reaction kinetics with pH and buffer strength, which induce changes in the structural features of hydrogels and determine their mechanical properties. Small-angle neutron scattering and swelling studies provide an insight into how structural properties correlate with mechanical properties for this hydrogel system.
Department of Polymer Science, The University of Akron, Akron, OH, 44325, USA.
Zachary K
ZK
Zander
Department of Polymer Science, The University of Akron, Akron, OH, 44325, USA.
Geng
G
Hua
Department of Polymer Engineering, The University of Akron, Akron, OH, 44325, USA.
Clinton G
CG
Wiener
Department of Polymer Engineering, The University of Akron, Akron, OH, 44325, USA.
Bryan D
BD
Vogt
Department of Polymer Science, The University of Akron, Akron, OH, 44325, USA.
Matthew L
ML
Becker
D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008422:Materials Testing; D015394:Molecular Structure; D033363:Neutron Diffraction; D012212:Rheology; D053838:Scattering, Small Angle
D020100:Hydrogels
hydrogels; microstructures; structure-property relationships; tissue engineering