HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation.
Hepatocellular carcinoma (HCC) is the most common primary liver tumor. Due to the asymptomatic nature of early HCC and lack of effective screening strategies, 80% of patients present with advanced HCC at the time of diagnosis. Novel molecular marker identification will be valuable for effective diagnosis and treatment. In this study we reported HCLS1-associated protein X-1 (HAX-1) is overexpression in HCC in human HCC sample. Furthermore, we provided evidence that HAX-1 expression positively correlated with that of Ki67 in patient sample. Statistic analysis indicated that HAX-1 expression level significantly correlated with clinic outcome of HCC. Cell based assay revealed that knockdown of HAX-1 inhibits cell proliferation. This result suggests that HAX-1 can be a novel molecular marker for HCC.
Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Medicine College, Shanghai Jiao Tong University Shanghai 200011, China.
Yanxia
Y
Wang
Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Medicine College, Shanghai Jiao Tong University Shanghai 200011, China.
Xin
X
Huo
Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Medicine College, Shanghai Jiao Tong University Shanghai 200011, China.
Zheng
Z
Cao
Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Medicine College, Shanghai Jiao Tong University Shanghai 200011, China.
Hui
H
Xu
Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Medicine College, Shanghai Jiao Tong University Shanghai 200011, China.
Jian
J
Zhu
Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Medicine College, Shanghai Jiao Tong University Shanghai 200011, China.
Li
L
Qian
Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Medicine College, Shanghai Jiao Tong University Shanghai 200011, China.
Hong
H
Fu
Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Medicine College, Shanghai Jiao Tong University Shanghai 200011, China.
Bing
B
Xu
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D034622:RNA Interference; D012307:Risk Factors; D015398:Signal Transduction; D013997:Time Factors; D014162:Transfection; D015854:Up-Regulation
D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; C104759:HAX1 protein, human
HAX-1; Human hepatocellular carcinoma (HCC); cell proliferation