Significant association between parathyroid hormone and uric acid level in men.
BACKGROUND
Previous reports of patients undergoing parathyroidectomy and of patients receiving teriparatide as antiosteoporotic treatment have suggested a plausible relationship between parathyroid hormone (PTH) and uric acid. However, similar data at population level were lacking. The current study aimed to determine the relationship between PTH and uric acid in a group of apparently healthy Malaysian men.


METHODS
A cross-sectional study was conducted among 380 Malay and Chinese men aged 20 years and above, residing in the Klang Valley, Malaysia. Their body anthropometry was measured, and their fasting blood samples were collected for biochemical analysis. The relationship between PTH and uric acid was analyzed using regression analysis.


RESULTS
Increased serum PTH level was significantly associated with increased serum uric acid level (β=0.165; P=0.001). Increased PTH level was also significantly associated with the condition of hyperuricemia in the study population (odds ratio [OR], 1.045; 95% confidence interval [CI], 1.017-1.075; P=0.002). All analyses were adjusted for age, body mass index, vitamin D, total calcium, inorganic phosphate, blood urea nitrogen and creatinine levels.


CONCLUSIONS
There is a significant positive relationship between PTH level and uric acid level in Malaysian men. This relationship and its clinical significance should be further investigated in a larger longitudinal study.
Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Kok-Yong
KY
Chin
Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Soelaiman Ima
SI
Nirwana
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Wan Zurinah Wan
WZ
Ngah
D000328:Adult; D001774:Blood Chemical Analysis; D015992:Body Mass Index; D001837:Body Weights and Measures; D003430:Cross-Sectional Studies; D006801:Humans; D033461:Hyperuricemia / Q000097:blood*; D008137:Longitudinal Studies; D008296:Malaysia; D008297:Male; D054526:Men's Health; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
D010281:Parathyroid Hormone; D014527:Uric Acid
Asian; cross-sectional study; hyperuricemia; urate; uric acid