Role of MMP-2 (-1306 C/T) Polymorphism in Age-Related Macular Degeneration.
To determine if the frequency of the MMP-2 (-1306 C/T) genotype has an influence on the development of early age-related macular degeneration (AMD).



The study enrolled 387 patients with early AMD and a random sample of 682 healthy persons (control group). The genotyping of MMP-2 (-1306 C/T) was carried out using the real-time polymerase chain reaction method.



The analysis of the MMP-2 (-1306 C/T) gene polymorphism did not reveal any differences in the genotype distribution between the patients with AMD and the control subjects. When the study population was divided into age groups, the C/C genotype was more prevalent in the AMD patients aged <65 years than those aged ≥65 years (65.19% versus 53.88%, p = 0.0294), and the C/T genotype was more frequent in the AMD patients aged ≥65 years when compared with the AMD patients aged <65 years (40.78% versus 26.52%, p = 0.0037). Moreover, in the female group younger than 65 years, the frequency of the C/C genotype was greater in the AMD group than the control group (75% versus 58.91%, p = 0.0232).



This study showed a significantly greater prevalence of the C/C and C/T genotypes in the patients with AMD younger than 65 years and those aged ≥65 years, respectively. Moreover, the AMD women aged <65 years were the carriers of the C/C genotype significantly more frequently than their control counterparts.
a Department of Ophthalmology .|b Neuroscience Institute .
Rasa
R
Liutkeviciene
c Institute of Cardiology , and.
Vaiva
V
Lesauskaite
d Department of Cardiology , Medical Academy, Lithuanian University of Health Sciences , Kaunas , Lithuania.
Diana
D
Zaliaduonyte-Peksiene
c Institute of Cardiology , and.
Giedre
G
Sinkunaite-Marsalkiene
a Department of Ophthalmology .
Dalia
D
Zaliuniene
d Department of Cardiology , Medical Academy, Lithuanian University of Health Sciences , Kaunas , Lithuania.
Vaida
V
Mizariene
d Department of Cardiology , Medical Academy, Lithuanian University of Health Sciences , Kaunas , Lithuania.
Olivija
O
Gustiene
a Department of Ophthalmology .
Vytautas
V
Jasinskas
c Institute of Cardiology , and.
Abdonas
A
Tamosiunas
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D060005:Genotyping Techniques; D064368:Healthy Volunteers; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D060888:Real-Time Polymerase Chain Reaction
C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
Age-related macular degeneration; gene polymorphism; matrix metalloproteinase-2