Exploiting Combinatorial Interactions to Expand NLR Specificity.
Intracellular nucleotide-binding leucine-rich repeat (NLR) receptors play central roles in human and plant innate immunity. In this issue of Cell Host & Microbe, Wang et al. (2015) show that a single plant NLR can detect diverse pathogen effectors by partnering with different scaffolding proteins, which can each recognize distinct effector targets.
Department of Biology, Indiana University, 915 East Third Street, Bloomington, IN 47405, USA. Electronic address: rinnes@indiana.edu.
Roger W
RW
Innes
D017360:Arabidopsis / Q000276:immunology* / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D010940:Plant Proteins / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D037521:Virulence Factors / Q000378:metabolism*; D016959:Xanthomonas campestris / Q000378:metabolism*
D010940:Plant Proteins; D037521:Virulence Factors