Catalytic Decarboxylative Cross-Coupling of Aryl Chlorides and Benzoates without Activating ortho Substituents.
The restriction of decarboxylative cross-coupling reactions to ortho-substituted or heterocyclic carboxylate substrates was overcome by holistic optimization of a bimetallic Cu/Pd catalyst system. The combination of a CuI/Me4 phen decarboxylation catalyst and a [(MeCN)4 Pd](OTf)2 /XPhos cross-coupling catalyst enables the synthesis of biaryls from inexpensive aryl chlorides and potassium benzoates regardless of their substitution pattern.
FB Chemie-Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Strasse Geb. 54, 67663 Kaiserslautern (Germany) http://www.chemie.uni-kl.de/goossen.
Jie
J
Tang
FB Chemie-Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Strasse Geb. 54, 67663 Kaiserslautern (Germany) http://www.chemie.uni-kl.de/goossen.
Agostino
A
Biafora
FB Chemie-Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Strasse Geb. 54, 67663 Kaiserslautern (Germany) http://www.chemie.uni-kl.de/goossen. goossen@chemie.uni-kl.de.
Lukas J
LJ
Goossen
aryl chlorides; benzoic acids; copper; cross-coupling; palladium