Immunophenotype Heterogeneity in Nasal Glomangiopericytoma.
Nasal glomangiopericytoma is rare. The immunophenotype is heterogeneous, more frequently smooth-muscle-actin and CD34-positive. We report expression patterns for several vascular-related proteins such as CD99, CD146, Bcl2, and WT1 as well as for treatment-related proteins such as mTOR and EGFR in a nasal glomangiopericytoma. The patient (woman, 86 years) presented with a left nasal tumefaction. The resected specimen (1.5-cm) showed a glomangiopericytoma. Tumor cells expressed smooth-muscle-actin, CD31, CD34, and progesterone receptor. They also expressed the vascular-cell-related proteins Bcl2, CD99, CD146, and WT1, as well as mTOR and EGFR. Nasal glomangiopericytomas show immunohistochemical heterogeneity for vascular-related markers, suggesting a possible extensive pericytic differentiation. The expression of potential targets for drug treatments such as mTOR and EGFR may impact on the clinical follow-up of these tumors occurring at advanced ages, which may require complex surgery.
APHP, Université Paris Nord Sorbonne Cité, 93009 Bobigny, France.
Adriana
A
Handra-Luca
Tulane Medical School, New Orleans, LA 70118, USA.
Zakaria Y
ZY
Abd Elmageed
Evaggelismos General Hospital, 10675 Athens, Greece.
Christina
C
Magkou
Institut Curie, 75005 Paris, France.
Marick
M
Lae