A case of matrix-producing carcinoma of the breast with micoglandular adenosis and review of literature.
Matrix-producing carcinoma (MPC) of the breast is an extremely rare variant of metaplastic breast carcinoma that contains a mixture of epithelial and mesenchymal elements. As overt carcinoma with direct transition to a cartilaginous and/or osseous stromal matrix cells, MPC is of no spindle cells between those two elements. This is the case of a 43 year-old female patient with MPC which coexisted with microglandular adenosis (MGA), atypical MGA (AMGA) and carcinoma in situ arising in MGA (MGACA in situ). MGA is a rare, infiltrative, benign lesion of the breast with an indolent clinical course. Histological evidence of carcinoma arising from MGA has previously been documented. MPC arising in MGA is an extremely rare subtype of breast carcinoma and has been seldom detailed described in the previous studies. This report highlights one such case with cytomorphological and histopathological correlation, along with a review of pertinent literature and differential diagnosis.
Department of Pathology, Tangshan Gongren Hospital Tangshan, China.
Li-Yun
LY
Liu
Department of Breast Surgery, Tangshan Gongren Hospital Tangshan, China.
Shu-Hai
SH
Sheng
Department of Pathology, Tangshan Gongren Hospital Tangshan, China.
Zhi-Yong
ZY
Zhang
Department of Pathology, Tangshan Gongren Hospital Tangshan, China.
Jin-Heng
JH
Xu
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D002278:Carcinoma in Situ / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D005109:Extracellular Matrix / Q000737:chemistry* / Q000473:pathology; D005260:Female; D005348:Fibrocystic Breast Disease / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D008327:Mammography; D015411:Mastectomy, Modified Radical; D018615:Ultrasonography, Doppler, Color; D016217:Ultrasonography, Mammary / Q000379:methods
D014408:Biomarkers, Tumor
Matrix-producing carcinoma; metaplastic breast carcinoma; microglandular adenosis