No changes of cardiometabolic and body composition parameters after 6-month add-on treatment with sarcosine in patients with schizophrenia.
This study was undertaken with the purpose to determine if there are changes in metabolic parameters during 6-month add-on treatment with sarcosine in patients with schizophrenia. This was a randomized double blind, placebo-controlled and parallel group study. Eligible participants were randomly assigned to receive 2g of sarcosine (n=30) or placebo (n=29). Sarcosine was administered as supplementation to the ongoing antipsychotic treatment. Augmentation with sarcosine had no effect on any of the analyzed cardiometabolic parameters. Also, augmentation with sarcosine had no effect on any of the analyzed body composition parameters. This is the first randomized placebo-controlled study to examine the metabolic safety of sarcosine in patients with schizophrenia. Clinically, this observation is of high importance considering how prevalent are metabolic abnormalities in patients with schizophrenia.
Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Dominik
D
Strzelecki
Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Olga
O
Kałużyńska
Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Justyna
J
Szyburska
Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Agata
A
Wlazło
Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland. Electronic address: adam.wysokinski@umed.lodz.pl.
Adam
A
Wysokiński
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001823:Body Composition / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D012521:Sarcosine / Q000008:administration & dosage*; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D001786:Blood Glucose; D008055:Lipids; D012521:Sarcosine
Metabolic syndrome; Sarcosine; Schizophrenia