The importance of early diagnosis in patients with maxillary sinus carcinoma.
There are two major challenges in the early diagnosis of maxillary sinus carcinoma: the maxillary sinus is not susceptible to direct inspection and palpation, and symptoms are uncharacteristic. The aim of this study was to assess the impact of the time interval between first symptoms noticed by the patient and the detection of the tumor on survival. 88 patients with maxillary sinus tumors were included in the retrospective study. Prognostic factors were identified through univariate analysis. Univariate analysis (p = 0.019) revealed a significant impact of the time interval from first symptom to diagnosis on overall survival. With increasing duration of the symptoms 5-year overall survival was reduced from 65 % for duration between 0 and 2 months to 24 % for duration of symptoms longer than 12 months. Furthermore, we found a significant association (p = 0.033) between local extension of the tumor and time interval from first symptom to diagnosis. Early diagnosis is often difficult because of uncharacteristic symptoms, which are identical with benign diseases of the maxillary sinus. The delay between the occurrence of the first symptom and diagnosis often makes a curative treatment impossible.
Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.|Centre of Integrated Oncology (CIO), Cologne-Bonn, Germany.
Matthias
M
Kreppel
Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany. asafi@outlook.de.|Centre of Integrated Oncology (CIO), Cologne-Bonn, Germany. asafi@outlook.de.
Ali-Farid
AF
Safi
Department for Oral and Maxillofacial Surgery, Johannes-Wesling Hospital, Muehlenkreiskliniken, Minden, Germany.
Martin
M
Scheer
Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.|Centre of Integrated Oncology (CIO), Cologne-Bonn, Germany.
Hans-Joachim
HJ
Nickenig
Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.|Centre of Integrated Oncology (CIO), Cologne-Bonn, Germany.
Joachim
J
Zöller
Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.|Centre of Integrated Oncology (CIO), Cologne-Bonn, Germany.
Simon
S
Preuss
Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.|Centre of Integrated Oncology (CIO), Cologne-Bonn, Germany.
Moritz
M
Meyer
Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.|Centre of Integrated Oncology (CIO), Cologne-Bonn, Germany.
Daniel
D
Rothamel
Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.|Centre of Integrated Oncology (CIO), Cologne-Bonn, Germany.
Timo
T
Dreiseidler
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000401:mortality; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis* / Q000401:mortality; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
Delay of diagnosis; Early symptoms; Maxillary sinus cancer; Multivariate analysis; Prognosis