Alcohol-independent beneficial cardiometabolic profile of individuals with hyper-HDL cholesterolemia in Japanese men and women.
BACKGROUND
There is limited information on characterization of individuals with hyper-high-density lipoprotein (HDL) cholesterolemia.


OBJECTIVE
The purpose of this study was to investigate the cardiometabolic profile of individuals with hyper-HDL cholesterolemia in comparison with the profile of individuals with normo-HDL cholesterolemia.


METHODS
The subjects were Japanese men and women who had hyper-HDL cholesterolemia (≥100 mg/dL) and their control subjects who had normal HDL cholesterol levels (≥40 and <80 mg/dL) and were matched for age or age and alcohol consumption. The cardiometabolic profiles were compared between the hyper- and normo-HDL cholesterolemic groups.


RESULTS
Both in men and women, body mass index, waist-to-height ratio, triglycerides, low-density lipoprotein cholesterol, and hemoglobin A1c were significantly lower in subjects with hyper-HDL cholesterolemia than in subjects with normo-HDL cholesterolemia, whereas systolic and diastolic blood pressure levels were not significantly different between the 2 groups. In generalized estimating equation with adjustment for smoking and regular exercise, odds ratios of the hyper- vs normo-HDL cholesterolemic groups were significantly lower than the reference level of 1.00 for high body mass index, high waist-to-height ratio, hypertriglyceridemia, hyper-low-density lipoprotein cholesterolemia, high lipid accumulation product, and metabolic syndrome. The previously mentioned results were obtained both in age-matched analysis and in age- and alcohol intake-matched analysis, although the percentage of regular drinkers was significantly higher in the hyper-HDL cholesterolemic group than in the age-matched control group.


CONCLUSIONS
Hyper-HDL cholesterolemia was inversely associated with obesity, dyslipidemia, and metabolic syndrome in the analysis using alcohol intake-matched subject groups. Therefore, the association of hyper-HDL cholesterolemia with lower cardiometabolic risk is thought to be independent of habitual alcohol drinking.
Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. Electronic address: wakabaya@hyo-med.ac.jp.
Ichiro
I
Wakabayashi
Division of Biostatistics, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Takashi
T
Daimon
D000328:Adult; D000428:Alcohol Drinking; D002318:Cardiovascular Diseases / Q000150:complications / Q000517:prevention & control; D002319:Cardiovascular System / Q000378:metabolism*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012306:Risk
D008075:Lipoproteins, HDL
Alcohol; Cardiovascular disease; Diabetes mellitus; Dyslipidemia; Hyper-HDL cholesterolemia; Metabolic syndrome; Obesity