High-sensitivity C-reactive protein and mean platelet volume as predictive values after percutaneous coronary intervention for long-term clinical outcomes: a comparable and additive study.
This study was designed to establish the relationship of high-sensitivity C-reactive protein (hsCRP) and mean platelet volume (MPV) with the development of adverse outcomes after percutaneous coronary intervention (PCI). hsCRP levels and MPV were analysed in 372 patients who underwent PCI, with the primary endpoint as major adverse cardiac and cerebrovascular events (MACCE): a composite of cardiac death, myocardial infarction (MI), target vessel revascularization (TVR), ischemic stroke and stent thrombosis. During the follow-up period (mean, 25.8 months), there were 21 cardiac deaths, 10 MIs including four stent thrombosis events, seven ischemic strokes and 29 TVRs. The hsCRP cut-off level was set at 0.31 mg/dl using the receiver operating characteristic curve to differentiate between the groups with and without MACCE. The MPV cut-off level was set at 8.00 fl by the receiver operating characteristic curve to differentiate between the groups with and without MACCE. A Kaplan-Meier analysis revealed that the high hsCRP group (≥0.31 mg/dl) had a significantly higher cardiac death and MACCE rate than the low hsCRP group (<0.31 mg/dl), and the high MPV group (>8.00 fl) had a significantly higher cardiac death and MACCE rate than the low MPV group (≤8.00 fl). Furthermore, the high hsCRP and MPV groups were significantly associated with an increased risk of MACCE. These results show that hsCRP and MPV are predictive markers after PCI for MACCE; they are also additively associated with a higher risk of MACCE.
aDivision of Natural Medical Sciences, College of Health Science, Chosun University bDepartment of Internal Medicine cDepartment of Thoracic and Cardiovascular Surgery dDepartment of Anesthesiology and pain Medicine, Chosun University School of Medicine, Gwangju eDepartment of Thoracic and Cardiovascular Surgery, St. Carollo General Hospital, Jeollanam-do fDepartment of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju, Republic of Korea.
Ae Ran
AR
Moon
Dong-Hyun
DH
Choi
Su-Young
SY
Jahng
Bo-Bae
BB
Kim
Hong-Joo
HJ
Seo
Sang Hun
SH
Kim
Sang-Wan
SW
Ryu
Heesang
H
Song
Tae-Hyoung
TH
Kim
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D002985:Clinical Protocols; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods*; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors
D002097:C-Reactive Protein