Cross-Sectional Associations between Body Size, Circulating Sex-Steroid Hormones and IGF Components among Healthy Chinese Women.
The incidence of breast cancer has increased in Asian countries and rates of hormone receptor (HR) negative breast cancer exceed those of Western countries. Epidemiologic data suggest that the association between body size and BC risk may vary by HR status, and could differ geographically. While body size may influence BC risk by moderating the synthesis and metabolism of circulating sex-steroid hormones, insulin-like growth factor (IGF)-1 and related binding proteins, there is a dearth of literature among Asian women. We aimed to examine these specific associations in a sample of Chinese women. In Sichuan Province 143 women aged ≥40 years were recruited through outpatient services (2011-2012). Questionnaires, anthropometric measurements, and blood samples were utilized for data collection and linear regression was applied in data analyses. Among women <50 years we observed a non-monotonic positive association between body mass index (BMI) and 17β-estradiol, and a reversed J-shaped association between BMI and IGF-1 (p ≤0.05). We observed similar associations between waist-to-hip ratio and these markers. Our finding of augmented IGF-1 among women with low body mass may have implications for understanding breast tumor heterogeneity in diverse populations and should be evaluated in larger prospective studies with cancer outcomes.
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, 135 Dauer Drive, Chapel Hill, North Carolina, 27599, United States of America; Lineberger Comprehensive Cancer Center, 101 Manning Drive, Chapel Hill, North Carolina, 27514, United States of America.
Lauren E
LE
McCullough
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, 135 Dauer Drive, Chapel Hill, North Carolina, 27599, United States of America.
Erline E
EE
Miller
Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, 16 Ren Min Nan Lu, Chengdu, 610041, P.R. China.
Qiong
Q
Wang
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, 135 Dauer Drive, Chapel Hill, North Carolina, 27599, United States of America; Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, 16 Ren Min Nan Lu, Chengdu, 610041, P.R. China.
Jia-Yuan
JY
Li
The Comprehensive Guidance Center of Women's Health, Chengdu Women's and Children's Central Hospital, Shi Ye Street, Qingyang District, Chengdu, 610015, P.R. China.
Li
L
Liu
Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, 16 Ren Min Nan Lu, Chengdu, 610041, P.R. China.
Hui
H
Li
The Comprehensive Guidance Center of Women's Health, Chengdu Women's and Children's Central Hospital, Shi Ye Street, Qingyang District, Chengdu, 610015, P.R. China.
Jing
J
Zhang
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, 135 Dauer Drive, Chapel Hill, North Carolina, 27599, United States of America; Lineberger Comprehensive Cancer Center, 101 Manning Drive, Chapel Hill, North Carolina, 27514, United States of America.
Jennifer S
JS
Smith
D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D002681:China; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D011374:Progesterone / Q000097:blood*; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood*; D049629:Waist-Hip Ratio; D016387:Women's Health
D018972:Insulin-Like Growth Factor Binding Protein 3; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I