Bioanalysis in oncology drug discovery.
Bioanalysis is an important aspect of drug discovery process regardless of the chosen therapeutic area. There is a general misconception that bioanalysis is seldom important during the drug discovery process because there is no scrutiny of the data from a regulatory perspective. However, bioanalytical data gathered during the discovery stage enable several key decision(s) inclusive of termination of the program and/or creating adequate differentiation from the lead competitive molecules. The review covers various stage gate screens and experimental designs where bioanalytical data are extensively used for making an informed decision during the process of drug discovery.
Dr Reddy's Institute of Life Sciences, Gachibowli, Hyderabad, Telangana, India.
Nuggehally R
NR
Srinivas
Drug Metabolism & Pharmacokinetics, Jubilant Biosys, Yeshwanthpur, Bangalore, Karnataka, India.
Ramesh
R
Mullangi
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents
LC-MS/MS; bioanalysis; drug discovery; oncology