The Effect of Cationic Polyamidoamine Dendrimers on Physicochemical Characteristics of Hydrogels with Erythromycin.
Polyamidoamine dendrimers (PAMAM) represent a new class of hyperbranched, monodisperse, three-dimensional polymers with unique properties, which make them very promising carriers of antimicrobial agents. The present study aimed to evaluate the influence of PAMAM-NH₂ dendrimers generation two (G2) or three (G3) on physicochemical characteristics and structure of hydrogels with a model antibacterial lipophilic drug-erythromycin-commonly used in topical applications. From the obtained rheograms, it can be concluded that tested hydrogels were non-Newtonian thixotropic systems with shear-thinning behaviour. The dissolution tests revealed that erythromycin was definitely faster released from formulations containing PAMAM-NH₂ in concentration and generation dependent manner. However, the addition of PAMAM-NH₂ to hydrogels evoked only slight improvement of their antibacterial activity. It was also shown that the structure of hydrogels changed in the presence of PAMAM-NH₂ becoming less compact, diversified and more porous. Designed hydrogels with PAMAM-NH₂ G2 or G3 were stable stored up to three months at 40 ± 2 °C and 75% ± 5% RH.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland. magdalena.wroblewska@umb.edu.pl.
Magdalena
M
Wróblewska
Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland. kwin@umb.edu.pl.
Katarzyna
K
Winnicka
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002412:Cations / Q000737:chemistry*; D055598:Chemical Phenomena; D050091:Dendrimers / Q000737:chemistry*; D065546:Drug Liberation; D004917:Erythromycin / Q000008:administration & dosage*; D020100:Hydrogels / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D002412:Cations; D050091:Dendrimers; D020100:Hydrogels; C104700:PAMAM Starburst; C531249:Poly(amidoamine); D011073:Polyamines; D004917:Erythromycin
PAMAM dendrimer; erythromycin; hydrogel; mechanical properties; rheological properties