Serum VEGF and PGF may be significant markers in prediction of severity of preeclampsia.
OBJECTIVE
The aim of this study evaluate the value of vascular endothelial growth factor (VEGF) and placental growth factor (PGF) serum levels in prediction of preeclampsia, severity and onset time of the disease.


METHODS
Twenty five placentas of pregnant women diagnosed with preeclampsia (15 severe preeclampsia, 10 mild preeclampsia) and peripheral venous blood samples were collected. The placental and serum levels of VEGF and PGF were measured.


RESULTS
VEGF level was significantly higher in cases and the optimal cut-off point was calculated as 600.5 to differentiate the cases and the controls, with 64% sensitivity and 100% specificity. There was a significant increase in median serum level of VEGF in severe cases compared to the mild cases and the controls. The optimal cut-off point for VEGF was calculated as 673.5 to differentiate mild and severe cases, with 93.3% sensitivity and 90% specificity. Whereas, PGF was significantly lower in severe cases than that in the mild cases and controls. The optimal cut-off point for PGF was calculated as 16.1 to differentiate mild and severe cases, with 66.7% sensitivity and 100% specificity.


CONCLUSIONS
VEGF and PGF may be significant markers in prediction of severity of preeclampsia, and VEGF may also be valuable in prediction of preeclampsia.
a Department of Obstetrics and Gynecology , Ondokuz Mayis University , Samsun , Turkey and.
Emel
E
Kurtoglu
b Department of Medical Biochemistry, Faculty of Medicine , Ondokuz Mayis University , Samsun , Turkey.
Bahattin
B
Avci
a Department of Obstetrics and Gynecology , Ondokuz Mayis University , Samsun , Turkey and.
Arif
A
Kokcu
a Department of Obstetrics and Gynecology , Ondokuz Mayis University , Samsun , Turkey and.
Handan
H
Celik
a Department of Obstetrics and Gynecology , Ondokuz Mayis University , Samsun , Turkey and.
Mustafa
M
Cengiz Dura
a Department of Obstetrics and Gynecology , Ondokuz Mayis University , Samsun , Turkey and.
Erdal
E
Malatyalioglu
a Department of Obstetrics and Gynecology , Ondokuz Mayis University , Samsun , Turkey and.
Ayse
A
Zehra Ozdemir
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor
Maternal serum; placenta; placental growth factor; preeclampsia; vascular endothelial growth factor