Draft genome sequence of Streptomyces sp. TP-A0882 reveals putative butyrolactol biosynthetic pathway.
We report the draft genome sequence of marine-derived Streptomyces sp. TP-A0882, a producer of buryrolactol, an antifungal γ-lactone-containing polyketide. The genome harbored at least three type I polyketide synthase (PKS), three type II PKS, four nonribosomal peptide synthetase (NRPS) and two hybrid PKS/NRPS gene clusters. Annotation of gene functions enabled us to identify the type I PKS gene cluster for butyrolactol biosynthesis and propose a plausible biosynthetic pathway for this unique polyketide.
Biological Resource Center, National Institute of Technology and Evaluation (NBRC), Chiba 292-0818, Japan komaki-hisayuki@nite.go.jp.
Hisayuki
H
Komaki
NBRC, Tokyo 151-0066, Japan.
Natsuko
N
Ichikawa
NBRC, Tokyo 151-0066, Japan.
Akira
A
Hosoyama
NBRC, Tokyo 151-0066, Japan.
Nobuyuki
N
Fujita
Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama 939-0398, Japan.
Yasuhiro
Y
Igarashi
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D053898:Biosynthetic Pathways; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D061065:Polyketides / Q000378:metabolism*; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism*
D001426:Bacterial Proteins; D061065:Polyketides
Actinomycete; antibiotic; biosynthesis; genome mining; thiazostatin