CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia are the independent risk factors for prediabetes in a Vietnamese population.
BACKGROUND
People with prediabetes are at greater risk for heart attack, stroke, kidney disease, vision problems, nerve damage and high blood pressure, compared to those without the disease. Prediabetes is a complex disorder involving both genetic and environmental factors in its pathogenesis. This cross-sectional study aimed to investigate the independent risk factors for prediabetes, considering the contribution of genetic factors (TCF7L2-rs7903146, IRS1-rs1801278, INSR-rs3745551, CDKN2A-rs10811661, and FTO-rs9939609), socio-economic status, and lifestyle factors.


RESULTS
Among the candidate genes studied, the CDKN2A-rs10811661 polymorphism was found to be the most significant factor associated with prediabetes in the model unadjusted and adjusted for age, sex, obesity-related traits, systolic blood pressure, dyslipidemia, socio-economic status, and lifestyle factors. In the final model, the CDKN2A-rs10811661 polymorphism (OR per T allele = 1.22, 95 % CI = 1.04-1.44, P = 0.017), systolic blood pressure (OR per 10 mmHg = 1.14, 95 % CI = 1.08-1.20, P < 0.0001), waist-hip ratio (OR = 1.25, 95 % CI = 1.10-1.42, P < 0.0001), dyslipidemia (OR = 1.57, 95 % CI = 1.15-2.14, P = 0.004), and residence (OR = 1.93, 95 % CI = 2.82-4.14, P < 0.0001) were the most significant independent predictors of prediabetes, in which the power of the adjusted prediction model was 0.646.


CONCLUSIONS
The study suggested that the CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia were significantly associated with the increased risk of prediabetes in a Vietnamese population. The studied genetic variant had a small effect on prediabetes.
National Institute of Hygiene and Epidemiology, 1 Yersin, Hanoi, 112800, Vietnam. binhtq@nihe.org.vn.
Tran Quang
TQ
Binh
Hanoi National University of Education, 136 Xuan Thuy Street, Hanoi, Vietnam. trungthu@hnue.edu.vn.
Nguyen Thi Trung
NT
Thu
National Institute of Hygiene and Epidemiology, 1 Yersin, Hanoi, 112800, Vietnam. phuong.pham@nihe.org.vn.
Pham Tran
PT
Phuong
National Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi, 112807, Vietnam. nhungvnnin@gmail.com.
Bui Thi
BT
Nhung
National Institute of Hygiene and Epidemiology, 1 Yersin, Hanoi, 112800, Vietnam. tuyetnhung0608@gmail.com.
Trinh Thi Hong
TT
Nhung
D000483:Alleles; D001794:Blood Pressure / Q000235:genetics*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics*; D050171:Dyslipidemias / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance; D012372:ROC Curve; D012307:Risk Factors; D014744:Vietnam / Q000453:epidemiology; D049629:Waist-Hip Ratio
D019941:Cyclin-Dependent Kinase Inhibitor p16