Primary bone metastasis as first manifestation of an unknown primary tumour.
Unknown primary tumour refers to a group of cancers for which the anatomical site of origin remains occult after detailed investigations. Thanks to sophisticated imaging, immunohistochemical testing and molecular-profiling tools, there is a more accurate approach to unknown primary cancer. Metastasis to bone is not a rare phenomenon, because any tumour can metastasise to bone, so it is a common clinical scenario. The role of clinical history, physical examination, laboratory tests, radiographic studies and immunohistochemistry is critical for a successful diagnostic strategy. Subsets of unknown primary cancers can be identified primarily on the basis of histopathological findings, the pattern of spread and serum markers. New immunohistochemical markers and tissue-of-origin profiles may establish presumable primary sites to unknown primary cancer on the basis of immunohistochemical and molecular patterns. We present a case of a 57-year-old woman without a cancer history, who had primary bone metastasis as the first manifestation of an occult primary tumour.
Mostoles General Hospital, Mostoles, Madrid, Spain.
Rafael
http://orcid.org/0000-0001-7532-4585
R
García Carretero
Department of Internal Medicine, Mostoles General Hospital, Mostoles, Madrid, Spain.
Marta
M
Romero Brugera
Department of Internal Medicine, Mostoles General Hospital, Mostoles, Madrid, Spain.
Noelia
N
Rebollo-Aparicio
Department of Pathology, Mostoles General Hospital, Mostoles, Madrid, Spain.
Liliam
L
El Bouayadi Mohamed
D001706:Biopsy; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary; D014057:Tomography, X-Ray Computed