Sorting Out Identities: An Educational Primer for Use with "Novel Tools for Genetic Manipulation of Follicle Stem Cells in the Drosophila Ovary Reveal an Integrin-Dependent Transition from Quiescence to Proliferation".
Organisms are made up of thousands of different cell types that must migrate, proliferate, and interact with each other to yield functional organ systems and ultimately a viable organism. A characteristic that distinguishes one cell type from another is the set of genes that it expresses. An article by Hartman et al. in the April 2015 issue of GENETICS identified methods to uniquely identify different cell populations during oogenesis, providing valuable tools for future studies. This Primer article provides background information on the Drosophila ovary as a system in which to study stem cell regulation, mechanisms for regulating gene expression, and the techniques used by Hartman et al. to identify specific cell populations and study their function.
Department of Biology, Loyola University Chicago, Chicago, Illinois 60660.
Diane
D
Silva
Department of Biology, Loyola University Chicago, Chicago, Illinois 60660 jmierisch@luc.edu.
Jennifer C
JC
Jemc
D000818:Animals; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D016023:Integrins / Q000235:genetics / Q000378:metabolism*; D009866:Oogenesis; D006080:Ovarian Follicle / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
D029721:Drosophila Proteins; D016023:Integrins
Drosophila melanogaster; follicle stem cell; integrin; ovary; transcriptional regulatory elements