Antitumor Compounds from the Stout Camphor Mushroom Taiwanofungus camphoratus (Higher Basidiomycetes) Spent Culture Broth.
A known compound, 5-(hydroxymethyl) furan-2-carbaldehyde, and a novel compound, 3-isobutyl-1-methoxy-4-(4'-(3-methylbut-2-enyloxy)phenyl)-1H-pyrrole-2,5-dione were isolated from spent broth from submerged cultures of Taiwanofungus camphoratus. Their structures were elucidated by nuclear magnetic resonance (1H, 13C, and 2D) and mass spectra. These compounds inhibited the proliferation of K562 and HepG2 tumor cells in vitro.
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungi.
Wei
W
Jia
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungi.
Yan-Yan
YY
Bai
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungi.
Zhong
Z
Zhang
Insitute of Edible Fungi,Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization, Shanghai Key Laboratory of Agricultural Genetics and Breeding, China.
Na
N
Feng
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi; Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, Shanghai, People's Republic of China.
Jie
J
Feng
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi; Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, Shanghai, People's Republic of China.
Meng-Qiu
MQ
Yan
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi; Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, Shanghai, People's Republic of China.
Li-Na
LN
Zhu
College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China.
Xin-Cheng
XC
Jia
College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China.
Ming-Dao
MD
Wang
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungi.
Jing-song
JS
Zhang
Institut fur Laboratoriumsmedizin, Klinische Chemie, Charite Universitatsmedizin, Berlin, Germany.
Hua
H
Fan
D000363:Agaricales / Q000254:growth & development* / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003470:Culture Media / Q000737:chemistry*; D022781:Hepatocytes / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
D000970:Antineoplastic Agents; D003470:Culture Media