New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol.
Osteoradionecrosis (ORN) of the jaw is a significant complication of radiotherapy for oral cavity cancer. In addition to antibiotic medication, treatment options such as hyperbaric oxygen therapy, surgical approaches, and combined therapy with pentoxifylline and tocopherol have been recently introduced. In this review article, we will discuss the definition and classifications of osteoradionecrosis, its etiology and pathophysiology, previous treatment options, oral and maxillofacial complications of radiotherapy, basic information on pentoxifylline and tocopherol, recent reports of pentoxifylline and tocopherol combined therapy, and, finally, ORN-induced animal models and future approaches.
Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 62-1 Changgyeonggungno, Jongno-gu, Seoul, 110-768 South Korea.
Huan
H
Fan
Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 62-1 Changgyeonggungno, Jongno-gu, Seoul, 110-768 South Korea.
Soung Min
SM
Kim
Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 62-1 Changgyeonggungno, Jongno-gu, Seoul, 110-768 South Korea.
Yun Ju
YJ
Cho
Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 62-1 Changgyeonggungno, Jongno-gu, Seoul, 110-768 South Korea.
Mi Young
MY
Eo
Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, Gangneung, South Korea.
Suk Keun
SK
Lee
Department of Dental Pharmacology & Therapeutics, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea.
Kyung Mi
KM
Woo
Osteoradionecrosis (ORN); Pentoxifylline; Radiotherapy; Tocopherol