Collagenogenic invasion in the livers of viral hepatitis patients.
Our report aimed to investigate the physiopathological patterns of liver lesions patients during hepatitis. After being diagnosed clinically as hepatopathy (n=9), the liver biopsy samples were prepared to paraffin-sections and further subjected to routine and immunohistochemical stains. Among these lesioned livers invaded by viruses, immunity-regulatory molecules, such as CD20, CD4 and CD8, were significantly expressed. In addition, antigens of the hepatitis B virus (HBsAg and HBcAg) were positively detected in non-dependent way of hepatitis intervention. Furthermore, the pro-fibrotic promotor of vimentin (Vim) was labelled immunologically in mesenchymal cells within virus-attacked livers. These observations provide the clinicopathologic evidences that there is a potential association between immunodeficiency and collagenation in hepatitis patients when liver injury development. It also manifests that regulation of intrahepatic immunologic response may inhibition of excessive collagen generation prior to further progressing to hepatofibrosis.
College of Pharmacy, Guilin Medical University Guilin 541004, China.
Wei
W
Wu
Department of Pharmacy, The Second People's Hospital of Nanning City Guangxi, Nanning 530031, P. R. China.
Ka
K
Wu
College of Pharmacy, Guilin Medical University Guilin 541004, China.
Xing
X
Su
Faculty of Basic Medicine, Guilin Medical University Guilin 541004, China.
Min
M
Su
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D003094:Collagen / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D006509:Hepatitis B / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry* / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D014746:Vimentin / Q000032:analysis; D055815:Young Adult
D015415:Biomarkers; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D014746:Vimentin; D003094:Collagen
Hepatitis; collagenation; immunodeficiency; vimentin