Cognitive Impairments in LRRK2-Related Parkinson's Disease: A Study in Chinese Individuals.
BACKGROUND
LRRK2 S1647T has been identified as a polymorphic risk variant for Parkinson's disease (PD) in Chinese individuals. As LRRK2 is the most common genetic cause for PD, it has drawn great interest regarding whether cognitive impairments in PD are related with LRRK2.


OBJECTIVE
This study aimed to explore the effects of LRRK2 S1647T polymorphism on cognitive function in PD.


METHODS
90 PD patients were randomly recruited. They underwent a series of clinical evaluations and genetic testing for the LRRK2 S1647T polymorphism. Global intellect and five cognitive domains (language fluency, visuospatial function, attention, memory, and executive function) were compared between S1647T carriers and noncarriers.


RESULTS
No differences in motor features were found between two groups, but the executive function evaluation showed that Stroop word colour test time (SWCT-TIME) scores were lower in LRRK2 S1647T carriers than in noncarriers (P = 0.017). However, multiple linear regression analysis indicated that the correlation between S1647T polymorphism and SWCT-TIME scores did not reach significant level (P = 0.051).


CONCLUSIONS
Our findings suggest that cognitive impairments are not correlated with different LRRK2 S1647T polymorphisms in Chinese PD individuals.
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Yifan
Y
Zheng
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Zhong
Z
Pei
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Yanmei
Y
Liu
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Hongyan
H
Zhou
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Wenbiao
W
Xian
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Yingying
Y
Fang
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Ling
L
Chen
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Qi
Q
Wu
D000368:Aged; D003072:Cognition Disorders / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases