Evaluation of Microvascularity by CD34 Expression in Esophagus and Oral Squamous Cell Carcinoma.
The present study was scheduled to evaluate microvascularity by CD34 expression in esophagus and oral squamous cell carcinoma.



This study was scheduled using 40 paraffin blocked samples including 20 of oral SCC and 20 of esophagus ones and Immunohistochemical staining was conducted using CD34 monoclonal antibody. Exact fisher test was used to evaluate frequency of expression between two studied groups.



There was significant correlation between age and tumor size with CD34 expression in oral SCC samples (p < 0.05) and no significant correlation between sex and tumor differentiation level (grading) (p > 0.05). Also, there was no significant correlation between age, sex, tumor size and tumor differentiation level (grading) with CD34 expression in esophagus SCC samples (p > 0.05). There was no significant difference of CD34 expression frequency in oral and esophagus SCC (p = 0/583). Finally, CD34 expression was reported 'high' for major cases of esophagus and oral SCCs.



It seems, other angiogenetic or nonangiogenetic factors except CD34 may play more important role and explain the different clinical behavior of SCC at recent different locations.



Other factors would be considered along with CD34 expression to interpret different clinical behavior of SCC at recent different locations.
Department of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran.
Fatemeh
F
Shahsavari
Assistant Professor, Department of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, No. 177, Fifth Golestan St, Pasdaran St, Tehran, Iran, Phone: +98 21 22542238, e-mail: dr.sfarhadi@gmail.com.
Sareh
S
Farhadi
Department of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran.
Donia
D
Sadri
Private Practice, Tehran, Iran.
Marzieh
M
Sedehi
D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D004938:Esophageal Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006258:Head and Neck Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D055806:Microvessels / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D011230:Precancerous Conditions / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D000077195:Squamous Cell Carcinoma of Head and Neck
D018952:Antigens, CD34
Angiogenesis; CD34; Esophagus squamous cell carcinoma; Oral squamous cell carcinoma.