Biogenesis and function of Porphyromonas gingivalis outer membrane vesicles.
Porphyromonas gingivalis is one of the keystone pathogens associated with chronic periodontitis. All P. gingivalis strains examined thus far produce outer membrane vesicles. Recent studies have found that vesicles possess some well-known virulence factors of P. gingivalis such as adhesins, toxins and proteolytic enzymes. Carrying most of the characteristic features of their parent P. gingivalis cells, vesicles communicate with host cells and other members of microbial biofilms, resulting in the transmission of virulence factors into these host cells and the formation of pathogenic bacteria-dominated microbial communities. An in-depth understanding of both the nature and role of vesicles in the pathogenicity of P. gingivalis is both important and timely, particularly when speaking of periodontitis and its related systemic effects.
Department of Oral Biology, School of Dentistry, Meharry Medical College, 1005 Dr DB Todd, Nashville, Tennessee, TN 37208, USA.
H
H
Xie
D018829:Adhesins, Bacterial / Q000378:metabolism; D018441:Biofilms; D006801:Humans; D059013:Microbial Consortia / Q000502:physiology; D001678:Organelle Biogenesis; D010518:Periodontitis / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000166:cytology* / Q000472:pathogenicity / Q000502:physiology* / Q000648:ultrastructure; D022161:Transport Vesicles / Q000502:physiology*; D037521:Virulence Factors / Q000378:metabolism
D018829:Adhesins, Bacterial; D037521:Virulence Factors
Gram-negative bacteria; interspecies interactions outer membrane vesicles; regulation of OMV biogenesis virulence factors