Electrochemical investigation of the voltammetric determination of hydrochlorothiazide using a nickel hydroxide modified nickel electrode.
The preparation and electrochemical characterization of a nickel hydroxide modified nickel electrode as well as its behavior as electrocatalyst toward the oxidation of hydrochlorothiazide (HCTZ) were investigated. The electrochemical behavior of the modified electrode and the electrooxidation of HCTZ were explored using cyclic voltammetry. The voltammetric response of the modified electrode in the detection of HCTZ is based on the electrochemical oxidation of the Ni(II)/Ni(III) and a chemical redox process. The analytical parameters for the electrooxidation of HCTZ by the nickel hydroxide modified nickel electrode were obtained in NaOH solution, in which the linear voltammetric response was in the concentration range from 1.39×10(-5) to 1.67×10(-4)mol L(-1) with a limit of detection of 7.92×10(-6)mol L(-1) and a sensitivity of 0.138 μA Lmmol(-1). Tafel analysis was used to elucidate the kinetics and mechanism of HCTZ oxidation by the modified electrode.
Faculty of Science and Technology, São Paulo State University (UNESP), CEP 19060-900 Presidente Prudente, SP, Brazil.
Wesley B S
WB
Machini
Faculty of Science and Technology, São Paulo State University (UNESP), CEP 19060-900 Presidente Prudente, SP, Brazil.
Diego N
DN
David-Parra
Faculty of Science and Technology, São Paulo State University (UNESP), CEP 19060-900 Presidente Prudente, SP, Brazil. Electronic address: funcao@fct.unesp.br.
Marcos F S
MF
Teixeira
D003217:Conductometry / Q000295:instrumentation*; D004232:Diuretics / Q000652:urine; D004300:Doping in Sports / Q000517:prevention & control; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D006852:Hydrochlorothiazide / Q000652:urine*; D006878:Hydroxides / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D058573:Performance-Enhancing Substances / Q000652:urine*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000295:instrumentation*
D004232:Diuretics; D006878:Hydroxides; D058573:Performance-Enhancing Substances; D006852:Hydrochlorothiazide; C037473:nickel hydroxide; D009532:Nickel
Electrocatalyst sensor; Electrochemical behavior; Hydrochlorothiazide; Modified nickel electrode; Voltammetric determination