Meta-Analysis of Abdominal Aortic Aneurysm in Patients With Coronary Artery Disease.
The high coronary artery disease (CAD) prevalence in patients with abdominal aortic aneurysm (AAA) is well known. However, the inverse relation has been little explored. We present, based on a systematic review and meta-analysis of the published evidence, a critical appraisal of the issue of AAA prevalence and also AAA predictive risk factors in patients with CAD, comparing it with AAA prevalence in subjects without CAD. A total of 22 studies involving 13,388 patients with CAD met the inclusion criteria. Overall, AAA prevalence in patients with CAD was 8.4% (95% confidence interval [CI] 6.9 to 10.3), significantly higher than in subjects without CAD (odds ratio [OR] 2.42, 95% CI 2.08 to 2.81). Pooled analysis revealed that smoking, arterial hypertension, and concomitant carotid artery stenosis were significantly associated with AAA in patients with CAD (OR 1.72, 95% CI 1.14 to 2.61; OR 1.57, 95% CI 1.06 to 2.35; OR 2.14, 95% CI 1.20 to 3.79, respectively). In patients with CAD, AAA prevalence tended to be higher with concomitant peripheral artery disease (OR 2.66, 95% CI 0.82 to 8.61, p = 0.08). In conclusion, AAA prevalence was significantly higher in patients with CAD versus subjects without CAD.
European Genomic Institute for Diabetes, Lille, France; UNIV LILLE, Lille, France; INSERM UMR 1011, Lille, France; Institut Pasteur de Lille, Lille, France.
Ahmed
A
Elkalioubie
Cardiovascular and Pulmonary, and Hematology Department, Centre Hospitalier Régional Universitaire, Lille, France.
Stephan
S
Haulon
Department of Biostatistics, Université Lille Nord de France, UDSL, Lille, France; Biostatistics Unity, Centre Hospitalier Régional Universitaire, Lille, France.
Alain
A
Duhamel
European Genomic Institute for Diabetes, Lille, France; UNIV LILLE, Lille, France; INSERM UMR 1011, Lille, France; Institut Pasteur de Lille, Lille, France.
Mickael
M
Rosa
European Genomic Institute for Diabetes, Lille, France; UNIV LILLE, Lille, France; INSERM UMR 1011, Lille, France; Institut Pasteur de Lille, Lille, France; Cardiovascular and Pulmonary, and Hematology Department, Centre Hospitalier Régional Universitaire, Lille, France.
Antoine
A
Rauch
European Genomic Institute for Diabetes, Lille, France; UNIV LILLE, Lille, France; INSERM UMR 1011, Lille, France; Institut Pasteur de Lille, Lille, France.
Bart
B
Staels
European Genomic Institute for Diabetes, Lille, France; UNIV LILLE, Lille, France; INSERM UMR 1011, Lille, France; Institut Pasteur de Lille, Lille, France; Cardiovascular and Pulmonary, and Hematology Department, Centre Hospitalier Régional Universitaire, Lille, France.
Sophie
S
Susen
European Genomic Institute for Diabetes, Lille, France; UNIV LILLE, Lille, France; INSERM UMR 1011, Lille, France; Institut Pasteur de Lille, Lille, France; Cardiovascular and Pulmonary, and Hematology Department, Centre Hospitalier Régional Universitaire, Lille, France.
Eric
E
Van Belle
European Genomic Institute for Diabetes, Lille, France; UNIV LILLE, Lille, France; INSERM UMR 1011, Lille, France; Institut Pasteur de Lille, Lille, France; Cardiovascular and Pulmonary, and Hematology Department, Centre Hospitalier Régional Universitaire, Lille, France. Electronic address: annabelle.dupont-2@univ-lille2.fr.
Annabelle
A
Dupont
D017677:Age Distribution; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D016893:Carotid Stenosis / Q000150:complications; D003324:Coronary Artery Disease / Q000150:complications*; D048909:Diabetes Complications / Q000453:epidemiology; D019317:Evidence-Based Medicine; D005602:France / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D064887:Observational Studies as Topic; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects