Comparison of palonosetron, granisetron, and ramosetron for the prevention of postoperative nausea and vomiting after laparoscopic gynecologic surgery: a prospective randomized trial.
BACKGROUND
Selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are reported to have potent antiemetic effects for postoperative nausea and vomiting (PONV). The purpose of this study was to prospectively evaluate the efficacy of palonosetron, granisetron, and ramosetron for the prevention of PONV in patients undergoing laparoscopic gynecologic surgery.


METHODS
In this prospective, randomized observational study, 105 healthy female patients who were undergoing laparocopic hystectomy under general anaesthesia were enrolled (clinical trial number: NCT01752374, www.clinicaltrials.gov ). Patients were divided into three groups: the palonostron (0.075 mg i.v.; n = 35), the granisetron group (3 mg i.v.; n = 35), and the ramosetron group (0.3 mg i.v.; n = 35). The treatments were given before the end of surgery. The incidence of PONV, severity of nausea/vomiting, and the use of rescue antiemetic requirements during the first 48 h after surgery were evaluated.


RESULTS
The overall incidence of PONV was 33.3 % for this series. The number of complete responders at 48 h after the surgery was 21 (60.0 %) for palonosetron, 24 (68.6 %) for granisetron, and 26 (71.4 %) for ramosetron, representing no statistical difference (P = 0.086).


CONCLUSIONS
There were no significant differences in the overall incidence of postoperative nausea and vomiting and complete responders for palonosetron, granisetron and ramosetron group.


BACKGROUND



BACKGROUND
NCT01752374 , www.clinicaltrials.gov .
Department of Surgery, Gil Medical Center, Gachon University, School of Medicine, Incheon, South Korea. lws@gilhospital.com.
Won-Suk
WS
Lee
Department of Gynecology, Gil Medical Center, Gachon University, School of Medicine, Incheon, South Korea. lws@gachon.ac.kr.
Kwang-Beom
KB
Lee
Department of Gynecology, Gil Medical Center, Gachon University, School of Medicine, Incheon, South Korea. doug.ws.lee@gmail.com.
Soyi
S
Lim
Department of Anesthesiology Surgery, Gil Medical Center, Gachon University, School of Medicine, Incheon, South Korea. gachonlws@gmail.com.
Young Gin
YG
Chang
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D001562:Benzimidazoles / Q000627:therapeutic use; D004311:Double-Blind Method; D017829:Granisetron / Q000627:therapeutic use; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects; D007546:Isoquinolines / Q000627:therapeutic use; D010535:Laparoscopy / Q000009:adverse effects; D000077924:Palonosetron; D020250:Postoperative Nausea and Vomiting / Q000209:etiology / Q000517:prevention & control; D011446:Prospective Studies; D011812:Quinuclidines / Q000627:therapeutic use; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000627:therapeutic use
D001562:Benzimidazoles; D017829:Granisetron; D007546:Isoquinolines; D000077924:Palonosetron; D011812:Quinuclidines; C071315:ramosetron; D058831:Serotonin 5-HT3 Receptor Antagonists