Basal cell adenoma with S-100 positive stroma: a case report and literature review.
Basal cell adenoma (BCA) of the salivary gland with presence of abundant S-100-positive stromal cells has been rarely reported. A case occurring in a 75-year-old man is presented here, as well as a review of the literature on the subject. The patient presented with a nodule in the right parotid gland. In addition to the typical features of BCA, histologically the resected tumor showed a substantial amount of stroma rich in S-100-positive spindle cells, a rarely reported finding in BCA. These cells were unreactive with a panel of myoepithelial markers, including calponin, p63, muscle-specific actin (MSA), smooth muscle actin (SMA), cytokeratin 14 (CK14), and glial fibrillary acidic protein (GFAP). Our results, in accordance with other reports, do not support a myoepithelial nature of these S-100-positive cells, and their precise nature remains elusive.
General Dentistry and Emergency Care Unit, George Eastman Dental Hospital, Rome, Italy.
Emanuela
E
Ortolani
Department of Oral and Maxillo-facial Sciences, Pediatric Dentistry Unit, Sapienza University, Rome, Italy.
Antonella
A
Polimeni
Institute of Anatomic Pathology, Catholic University of Sacred Heart, Rome, Italy.
Libero
L
Lauriola
Institute of Anatomic Pathology, Catholic University of Sacred Heart, Rome, Italy. Electronic address: antonella.coli@rm.unicatt.it.
Antonella
A
Coli
D000236:Adenoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010307:Parotid Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D009418:S100 Proteins / Q000378:metabolism*
D014408:Biomarkers, Tumor; D009418:S100 Proteins