Inverse association between height increase and LDL cholesterol during puberty: A 3-year follow-up study of the Fukuroi City.
Few studies have reported on the association between changes in serum low-density lipoprotein cholesterol (LDL-C) and height increase. We investigated the association between LDL-C change and height increase during puberty in a 3-year follow-up study in Fukuroi City, Japan.



The source population was all fifth grade 2,515 students enrolled in any public school in Fukuroi, Japan in 2008, 2009, and 2010. The follow-up survey was conducted in eighth grade students in 2011, 2012, and 2013. In total, 2,225 adolescents were followed. To evaluate the relationships between height increases and changes in LDL-C, a regression analysis was conducted after stratification by tertiles of weight change (LW: lowest group, MW: middle group, and HW: highest group).



In each weight change tertile, serum LDL-C significantly decreased from the lowest to highest tertiles of height change (LW: regression coefficient (B) = -0.12, MW: B = -0.07, HW: B = -0.08 in males; MW: B = -0.17, HW: B = -0.14 in females). The association between height increases and LDL-C was significantly stronger than that between weight increases and LDL-C (male: B = -0.609 and 95% CI -0.836 to -0.382 in height, B = 0.008 and 95% CI -0.193 to 0.209 in weight; female: B = -0.963 and 95% CI -1.301 to -0.624 in height, B = 0.366 and 95% CI 0.058-0.675 in weight).



Serum LDL-C decreased with increasing height, independent of increases in weight. The association between LDL-C and height is stronger than that between LDL-C and weight. Am. J. Hum. Biol. 28:330-334, 2016. © 2015 Wiley Periodicals, Inc.
Department of Public Health, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, 589-8511, Japan.
Yuki
Y
Fujita
Department of Public Health, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, 589-8511, Japan.
Katsuyasu
K
Kouda
Department of Health Promotion and Education, Graduate School of Human Development and Environment, Kobe University, Kobe, 657-8501, Japan.
Harunobu
H
Nakamura
Department of Public Health, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, 589-8511, Japan.
Masayuki
M
Iki
D000293:Adolescent; D001827:Body Height; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008297:Male; D011627:Puberty; D012044:Regression Analysis
D008078:Cholesterol, LDL