STAT3: a critical component in the response to Helicobacter pylori infection.
STAT3 imparts a profound influence on both the epithelial and immune components of the gastric mucosa, and through regulation of key intracellular signal transduction events, is well placed to control inflammatory and oncogenic outcomes in the context of Helicobacter (H.) pylori infection. Here we review the roles of STAT3 in the host immune response to H. pylori infection, from both gastric mucosal and systemic perspectives, as well as alluding more specifically to STAT3-dependent mechanisms that might be exploited as drug targets.
Murdoch Children's Research Institute, Melbourne, Victoria, Australia.|Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Trevelyan R
TR
Menheniott
Murdoch Children's Research Institute, Melbourne, Victoria, Australia.|Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Louise M
LM
Judd
Murdoch Children's Research Institute, Melbourne, Victoria, Australia.|Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Andrew S
AS
Giraud
D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D007113:Immunity, Innate; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction
D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human