Oxygen Sensing and Homeostasis.
The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.
Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois; nanduri@uchicago.edu.
Nanduri R
http://orcid.org/0000-0003-4570-1380
NR
Prabhakar
Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland; and McKusick-Nathans Institute of Genetic Medicine and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Gregg L
GL
Semenza
D000223:Adaptation, Psychological; D000818:Animals; D002344:Carotid Body / Q000378:metabolism* / Q000503:physiopathology; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D008168:Lung / Q000378:metabolism* / Q000503:physiopathology; D010100:Oxygen / Q000378:metabolism*; D012119:Respiration; D015398:Signal Transduction; D014158:Transcription, Genetic
D010100:Oxygen