Alterations in Hepatic Lipid Metabolism, and their Relation to Dietary Macronutrients in Pediatric Nonalcoholic Fatty Liver Disease.
Nonacoholic fatty liver disease (NAFLD) is a common complication of pediatric obesity in which diet is a major factor in causation and the cornerstone of treatment. In this review, the alterations in hepatic lipid metabolism that contribute to pediatric NAFLD, and impact of dietary proteins, carbohydrates, and fats on hepatic fat metabolism and NAFLD are described. Lastly, dietary recommendations for achieving changes in macronutrient intakes that can be beneficial in the treatment of NAFLD are provided.
Harvard School of Public Health, Department of Nutrition, 665 Huntington Avenue, Boston MA, USA, 02119. davidstjules@gmail.com.
David E
DE
St-Jules
Corilee A
CA
Watters
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D004032:Diet / Q000009:adverse effects; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000009:adverse effects / Q000378:metabolism*; D004044:Dietary Proteins / Q000378:metabolism; D002149:Energy Intake; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism* / Q000503:physiopathology; D065626:Non-alcoholic Fatty Liver Disease / Q000178:diet therapy / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D009752:Nutritional Status; D063766:Pediatric Obesity / Q000178:diet therapy / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D011379:Prognosis; D012307:Risk Factors; D015431:Weight Loss
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins