Past and Present of Total Artificial Heart Therapy: A Success Story.
The totally artificial heart (TAH) is among the most prominent medical innovations of the 21st century, especially due to the increasing population with end-stage heart failure. The progressive course of the disease, its resistance to conventional therapy, and the scarcity of hearts available for transplantation were the prime impetus for developing a TAH, especially when other options of mechanical circulatory assist devices are exhausted. In this review, we narrate the history of TAH, give an overview of its technology, and address the pros and cons of the currently available TAH models in light of published clinical experience.
Department of Cardiothoracic Surgery, Heart Center, University Hospital Cologne, Cologne, Germany.
Mostafa
M
Samak
Department of Cardiothoracic Surgery, Heart Center, University Hospital Cologne, Cologne, Germany.
Javid
J
Fatullayev
Department of Cardiothoracic Surgery, Heart Center, University Hospital Cologne, Cologne, Germany.
Anton
A
Sabashnikov
Department of Cardiothoracic Surgery, Heart Center, University Hospital Cologne, Cologne, Germany.
Mohamed
M
Zeriouh
Department of Cardiothoracic Surgery, Heart Center, University Hospital Cologne, Cologne, Germany.
Parwis B
PB
Rahmanian
Department of Cardiothoracic Surgery, Heart Center, University Hospital Cologne, Cologne, Germany.
Yeong-Hoon
YH
Choi
Department of Cardiothoracic Surgery, Heart Center, University Hospital Cologne, Cologne, Germany.
Jens
J
Wippermann
Department of Cardiothoracic Surgery, Heart Center, University Hospital Cologne, Cologne, Germany.
Thorsten
T
Wahlers
Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg, Germany.
Bastian
B
Schmack
Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg, Germany.
Arjang
A
Ruhparwar
Department of Cardiovascular Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Pascal M
PM
Dohmen
Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg, Germany.
Matthias
M
Karck
Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom.
Aron-Frederik
AF
Popov
Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom.
André R
AR
Simon
Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, London, United Kingdom.
Alexander
A
Weymann
D006331:Heart Diseases / Q000601:surgery / Q000628:therapy*; D016027:Heart Transplantation / Q000379:methods* / Q000639:trends*; D006354:Heart, Artificial / Q000639:trends*; D006801:Humans; D011474:Prosthesis Design