miRNA Influences in NRF2 Pathway Interactions within Cancer Models.
The NRF2 transcription factor (nuclear factor-erythroid 2 p45-related factor 2) has been identified as a key molecular player in orchestrating adaptive cellular interactions following a wide spectrum of cellular stress conditions that could be either extracellular or intracellular. Dysregulation of the NRF2 system is implicated in various disease states, including inflammatory conditions. The NRF2 transcription factor is also known to permit cross talk with several other essential cellular signaling pathways. Recent literature has also elucidated the potential influences of miRNA activity over modulations of the NRF2 signalling network. Consequently, further delving into the knowledge regarding the extent of miRNA-induced epigenetic gene regulatory control on key elements of the NRF2 signalling pathway and its cross talk, particularly within the context of cancer models, can prove to be of high clinical importance. This is so since such miRNAs, once identified and validated, can be potentially exploited as novel drug targets for emerging translational medicine-based therapies.
Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, Malta ; Faculty of Medical and Human Sciences, The University of Manchester, Manchester M1 7DN, UK.
Duncan
D
Ayers
Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, Malta.
Byron
B
Baron
Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida MSD 2080, Malta.
Therese
T
Hunter