Lack of Association Between the IL1B (-511 and +3954), IL1RN VNTR Polymorphisms and Tuberculosis Risk: A Meta-analysis.
BACKGROUND
Several recent studies have provided evidence that polymorphisms in the interleukin-1 (IL1) gene are implicated in tuberculosis (TB). However, results of different studies are inconsistent. The aim of this study was to perform a meta-analysis investigating the association of the IL1B (-511 and +3954) and IL1RN VNTR polymorphisms with TB risk.


METHODS
A systematic review of the English literature was conducted by searching Pubmed, Scopus, and ISI Web of Knowledge databases for relevant studies. Pooled odds ratios (OR) with 95 % confidence intervals (CI) were calculated using fixed effects models. Between-study heterogeneity and publication bias were also evaluated.


RESULTS
Nine case-control studies including 3327 participants were reviewed and analyzed. Our results did not indicate any association of the IL1B (-511 and +3954) and IL1RN VNTR polymorphisms with TB risk in the overall populations. The pooled OR of the IL1B -511 polymorphism was 1.09 (95 % CI 0.87-1.36) for the dominant model, 1.11 (0.89-1.38) for the recessive model, 1.15 (0.87-1.50) for the homozygote model, and 1.07 (0.94-1.23) for the allelic comparison model. ORs for the IL1B +3954 and IL1RN VNTR polymorphisms were similar. In subgroup analysis stratified by ethnicity, the results revealed no association between these polymorphisms and TB risk in black people, Asians, and Caucasians, respectively. We did not identify significant between-study heterogeneity across all studies, and there was no evidence of publication bias.


CONCLUSIONS
Our results indicate there is a lack of association between the IL1B (-511 and +3954), IL1RN VNTR polymorphisms and TB risk.
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Qiu-Pin
QP
Huang
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Ning
N
Liao
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Hua
H
Zhao
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Min-Li
ML
Chen
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China. xie_zhengfu@yeah.net.
Zheng-Fu
ZF
Xie
D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D014376:Tuberculosis / Q000235:genetics*
C508585:IL1B protein, human; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta
Interleukin-1; Meta-analysis; Polymorphism; Tuberculosis