Prominent Vascular and Perivascular Eosinophilic Infiltrates Heralding CNS Mycosis Fungoides.
Brain parenchymal involvement of mycosis fungoides (MF) is very rare. This study reports a patient with known cutaneous MF (under treatment) who presented with a CNS syndrome and multiple brain lesions. Brain biopsy demonstrated massive eosinophilic infiltrates but no MF cells. Despite treatment, new lesions developed and the patient died. At autopsy, there was massive involvement MF cells, suggesting that the eosinophilic infiltrates presaged the severe involvement of the CNS by MF.
From the Departments of Pathology (JS, BKKD), Medicine (ML), Neurology (DN, BKKD), and Neurosurgery (BKKD), University of Colorado at Denver, Anschutz Medical Campus, Aurora, Colorado.
Jeffrey
J
Schowinsky
Michelle
M
Leppert
Douglas
D
Ney
B K
BK
Kleinschmidt-DeMasters
D001932:Brain Neoplasms / Q000473:pathology*; D004802:Eosinophilia / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*