CRYSTALLOID PRELOAD SHOWS TRANSIENT SUPERIORITY OVER COLLOID, OR THEIR COMBINATION IN SPINAL ANAESTHESIA-INDUCED HYPOTENSION PROPHYLAXIS FOR CAESAREAN SECTION.
BACKGROUND
Many studies comparing different intravenous fluid types usually do not use equipotent volumes of 3:1 crystalloid: colloid ratio in such comparisons. Conflicting results emanate from such studies. This study was designed to compare the efficacy of equipotent volumes of crystalloid, colloid and combination of crystalloid/colloid in spinal anaesthesia-induced hypotension prophylaxis.


METHODS
Pregnant women scheduled for elective Caesarean section were prospectively randomized to three groups to each received either 1 500 ml of Ringers lactate, or 500 ml of 6% pentastarch or a combination of 250 ml of 6% pentastarch and 750 ml of Ringers lactate intravenous fluid preload, before spinal anaesthesia. Hemodynamic variables were monitored.


RESULTS
First 10 minutes, crystalloid showed better efficacy in hypotension prophylaxis over the other regimen. In the next 30 minutes however, there were no significant differences between the groups.


CONCLUSIONS
Crystalloids proved more effective than colloid or their combination in hypotension prophylaxis in the first 10 minutes after spinal anaesthesia.
Idehen Hanson
IH
Osazuwa
Amadasun
A
Ebague
D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects / Q000379:methods; D000775:Anesthesia, Spinal / Q000009:adverse effects / Q000379:methods; D002585:Cesarean Section / Q000379:methods; D003102:Colloids / Q000008:administration & dosage / Q000009:adverse effects; D000077324:Crystalloid Solutions; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000517:prevention & control; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000009:adverse effects; D011247:Pregnancy; D015532:Rehydration Solutions / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
D003102:Colloids; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D015532:Rehydration Solutions