Impact of preoperative radiological and postoperative pathological findings on survival of patients after radical nephrectomy performed with the indication of renal cell carcinoma.
OBJECTIVE
To evaluate the impact of preoperative radiological and postoperative pathological findings on survival of patients after radical nephrectomy because of renal cell carcinoma (RCC).


METHODS
We performed 159 consecutive radical nephrectomy between December 2007 and January 2014. We evaluated age, gender, complaints, operation time, comorbidity, computed tomography (CT) and magnetic resonance graphy (MRG) results. Size of the mass, lymph node involvement, renal vein invasion, and presence of metastases were investigated. During histopathological examination, especially, pathological diagnosis, subtypes of RCC, lymph node involvement, lymphovascular, perineural invasion, and capsular, renal pelvis invasion, and renal vein involvement were sought. Follow-up periods of the patients were determined based on dates of death of the patients, and the study period.


RESULTS
RCC was seen in 124 (78%) of patients. Mean estimated suvival of RCC patients was 60 months and 5 year survival was 64%. Tumor size greater than 6.5 cm, lymph node involvement (p=0.006) and metastasis in radiological results (p<0.001), lymphovascular invasion (p=0.015) and stage of disease (p<0.001) found to be significantly affecting the survival. Lymph node involvement in radiological results (p=0.0089; HR: 4.6; CI 95%: 1.4753-14.3523) and stage of the disease (p= 0.0129; HR: 1.6; CI 95%: 1.1087-2.3461) were affecting the survival independently.


CONCLUSIONS
We found radiological lymph node involvement and stage of the disease as independent factors affecting the survival of RCC patients after radical nephrectomy.
Department of Urology, Haseki Training and Research Hospital, İstanbul, Turkey.
Abdulmuttalip
A
Şimşek
Department of Urology, Haseki Training and Research Hospital, İstanbul, Turkey.
Onur
O
Küçüktopcu
Department of Urology, Haseki Training and Research Hospital, İstanbul, Turkey.
Fatih
F
Akbulut
Department of Urology, Haseki Training and Research Hospital, İstanbul, Turkey.
Faruk
F
Özgör
Fatih Social Health Center, İstanbul, Turkey.
Elif
E
Küçüktopcu
Department of Urology, Haseki Training and Research Hospital, İstanbul, Turkey.
Metin
M
Savun
Department of Urology, Haseki Training and Research Hospital, İstanbul, Turkey.
Yalçın
Y
Berberoğlu
Department of Urology, Haseki Training and Research Hospital, İstanbul, Turkey.
Gökhan
G
Gürbüz
Kidney tumor; radical nephrectomy; renal cell carcinoma; survey analysis