rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery.
We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA. ljrtorvik@northwestern.edu.
Laura J
LJ
Rasmussen-Torvik
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA.
Abigail S
AS
Baldridge
Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jennifer A
JA
Pacheco
Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sharon A
SA
Aufox
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA.
Kwang-Youn A
KY
Kim
NorthShore Research Institute, NorthShore University Health System, Evanston, IL, USA.
Jonathan C
JC
Silverstein
NorthShore Research Institute, NorthShore University Health System, Evanston, IL, USA.
Erwin W
EW
Denham
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Eric
E
Hungness
Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Maureen E
ME
Smith
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA.
Philip
P
Greenland
D000328:Adult; D050110:Bariatric Surgery; D030541:Databases, Genetic; D039642:Eukaryotic Initiation Factors / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D009767:Obesity, Morbid / Q000235:genetics / Q000601:surgery*; D020641:Polymorphism, Single Nucleotide; D015431:Weight Loss / Q000235:genetics*
D039642:Eukaryotic Initiation Factors; C519156:MTIF3 protein, human; D024101:Mitochondrial Proteins
Bariatric surgery; Long-term weight loss; Obesity GWAS; Predictors; Repeated measures; Roux-en-Y gastric bypass; SNP