Acute kidney injury: preclinical innovations, challenges, and opportunities for translation.
BACKGROUND
Acute kidney injury (AKI) is a clinically important condition that has attracted a great deal of interest from the biomedical research community. However, acute kidney injury AKI research findings have yet to be translated into significant changes in clinical practice.


OBJECTIVE
This article reviews many of the preclinical innovations in acute kidney injury AKI treatment, and explores challenges and opportunities to translate these finding into clinical practice.


METHODS
MEDLINE, ISI Web of Science.


RESULTS
This paper details areas in biomedical research where translation of pre-clinical findings into clinical trials is ongoing, or nearing a point where trial design is warranted. Further, the paper examines ways that best practice in the management of AKI can reach a broader proportion of the patient population experiencing this condition.


CONCLUSIONS
This review highlights pertinent literature from the perspective of the research interests of the authors for new translational work in AKI. As such, it does not represent a systematic review of all of the AKI literature.


CONCLUSIONS
Translation of findings from biomedical research into AKI therapy presents several challenges. These may be partly overcome by targeting populations for interventional trials where the likelihood of AKI is very high, and readily predictable. Further, specific clinics to follow-up with patients after AKI events hold promise to provide best practice in care, and to translate therapies into treatment for the broadest possible patient populations.
Division of Nephrology, St. Michael's Hospital, University of Toronto, Toronto, Canada.
Samuel A
SA
Silver
Division of Nephrology, Centre Hospitalier de l'Université de Montréal and CHUM research center, Montreal, Quebec Canada.
Héloise
H
Cardinal
Department of Medicine, Division of Nephrology, McMaster University and St. Joseph's Healthcare Hamilton, Hamilton, Ontario Canada.
Katelyn
K
Colwell
Kidney Research Centre, Ottawa Hospital Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario Canada.
Dylan
D
Burger
Department of Medicine, Division of Nephrology, McMaster University and St. Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6 Canada.
Jeffrey G
0000-0002-3407-9349
JG
Dickhout
Acute kidney injury; Endoplasmic reticulum stress; Kidney transplant; Stem cells; Translational research