Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine.
A field of recent diagnostics and therapeutics has been advanced with quantum dots (QDs). QDs have developed into new formats of biomolecular sensing to push the limits of detection in biology and medicine. QDs can be also utilized as bio-probes or labels for biological imaging of living cells and tissues. More recently, QDs has been demonstrated to construct a multifunctional nanoplatform, where the QDs serve not only as an imaging agent, but also a nanoscaffold for diagnostic and therapeutic modalities. This review highlights the promising applications of multi-functionalized QDs as advanced nanosensors for diagnosing cancer and as innovative fluorescence probes for in vitro or in vivo stem cell imaging in regenerative medicine.
Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. Electronic address: onoshima-d@nanobio.nagoya-u.ac.jp.
Daisuke
D
Onoshima
ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. Electronic address: hiroshiy@med.nagoya-u.ac.jp.
Hiroshi
H
Yukawa
Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14, Hayashi-cho, Takamatsu 761-0395, Japan.
Yoshinobu
Y
Baba
D000818:Animals; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D045663:Quantum Dots / Q000627:therapeutic use; D044968:Regenerative Medicine / Q000379:methods; D033581:Stem Cell Transplantation
D005456:Fluorescent Dyes
Cancer diagnosis; Cationic liposomes; Cell transplantation; Cell-penetrating peptides; FRET; Microfluidic device; Quantum dots; Stem cell labeling