Properties of Taurine Release in Glucose-Free Media in Hippocampal Slices from Developing and Adult Mice.
The release of preloaded [(3)H]taurine from hippocampal slices from developing 7-day-old and young adult 3-month-old mice was studied in a superfusion system in the absence of glucose. These hypoglycemic conditions enhanced the release at both ages, the effect being markedly greater in developing mice. A depolarizing K(+) concentration accentuated the release, which indicates that it was partially mediated by exocytosis. The anion channel blockers were inhibitory, witnessing the contribution of ion channels. NO-generating agents fomented the release as a sign of the participation of excitatory amino acid receptors. The other second messenger systems were apparently less efficient. The much greater taurine release could be a reason for the well-known greater tolerance of developing nervous tissue to lack of glucose.
Medical School, 33014 University of Tampere, Finland.
Simo S
SS
Oja
Medical School, 33014 University of Tampere, Finland.
Pirjo
P
Saransaari