Hybrid Fe3O4-Poly(acrylic acid) Nanogels for Theranostic Cancer Treatment.
Multifunctional nanomedicine integrated with both therapy and diagnostics holds vast potential in cancer treatment. We developed hybrid Fe3O4-poly(acrylic acid) (PAA) nanogels for both drug delivery and magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 nanoparticles were encapsulated inside porous PAA nanogels via an in situ co-precipitation approach. With successive growth of magnetic nanoparticles, the highest magnetization saturation (M(s)) value of the Fe3O4 nanoparticles in the PAA nanogels was determined as 20 emu/g. The resulting hybrid Fe3O4-PAA nanogels showed high drug loading capacity (98%) and sustained drug release in vitro. Cytotoxicity assays and cellular imaging demonstrated that the hybrid nanogels were highly biocompatible and efficiently internalized in human neuroblastoma SH-SY5Y cells. In MRI studies, the hybrid nanogels exhibited an excellent contrast in T2 weighted imaging and a high MRI sensitivity in the tumor site.
Ying
Y
Chen
Jingya
J
Nan
Yue
Y
Lu
Chunpeng
C
Wang
Fuxiang
F
Chu
Zhen
Z
Gu
D000180:Acrylic Resins / Q000737:chemistry* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008422:Materials Testing; D051379:Mice; D008813:Mice, Inbred ICR; D000080385:Nanogels; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D011094:Polyethyleneimine / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured
D000180:Acrylic Resins; D000970:Antineoplastic Agents; D005290:Ferric Compounds; D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; C000499:ferric oxide; D011092:Polyethylene Glycols; C006903:carbopol 940; D004317:Doxorubicin; D011094:Polyethyleneimine