Hepatitis: Epigenetic control of HBV by HBx protein--releasing the break?
HBV persists by depositing covalently closed circular DNA (cccDNA) into the nucleus of infected host cells. HBV X protein (HBx) is a crucial determinant for regulating HBV activity, but the molecular details have not been fully understood. A new role for HBx in regulating cccDNA transcription has now been identified.
Institute of Virology, Technische Universität München and the Helmholtz Zentrum München, Trogerstrasse 30, D-81675 München, Germany.
Ulrike
U
Protzer
D004270:DNA, Circular; D004279:DNA, Viral / Q000235:genetics*; D006505:Hepatitis; D006506:Hepatitis A; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans
D004270:DNA, Circular; D004279:DNA, Viral