An efficient aldol-type direct reaction of isatins with TMSCH2CN.
Cesium fluoride catalyzed direct cyanomethylation of various isatins by using trimethylsilyl acetonitrile (TMSAN) as a nucleophile has been developed. The reaction has been explored for a number of isatins, with various substitutions on its aromatic ring. Further, the versatility of the reaction is demonstrated by converting the direct aldol adducts to the corresponding intermediates of natural products and medicinally important compounds.
Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, India 110016. ravips@chemistry.iitd.ac.in.
V U
VU
Bhaskara Rao
Krishna
K
Kumar
Ravi P
RP
Singh