Circadian Dysfunction and Obesity: Is Leptin the Missing Link?
While accumulating evidence suggests that circadian desynchrony is linked to obesity and metabolic syndrome, the underlining mechanism is still poorly understood. In this issue, Kettner et al. (2015) demonstrate that leptin resistance, induced by circadian clock deficiency or chronic jet lag, may represent this missing link.
Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Medical Specialties, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
Charna
C
Dibner
Department of Diabetes and Circadian Rhythms, Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland; Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: frederic.gachon@rd.nestle.com.
Frédéric
F
Gachon
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D057906:Circadian Clocks; D020738:Leptin / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*
D020738:Leptin