ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence.
Oncogene activation is usually not enough to induce cancer, but causes cells to arrest proliferation, alter chromatin structure, and increase protein secretion. In this issue of Molecular Cell, Chen et al. (2015) implicate the histone variant macroH2A.1 in the regulation of senescence.
Department of Physiological Chemistry, Biomedical Center, Ludwig-Maximilians-University of Munich, Butenandtstrasse 5, 81377 Munich, Germany; International Max Planck Research School for Molecular and Cellular Life Sciences, Am Klopferspitz 18, 82152 Martinsried, Germany.
Marek
M
Kozlowski
Department of Physiological Chemistry, Biomedical Center, Ludwig-Maximilians-University of Munich, Butenandtstrasse 5, 81377 Munich, Germany; International Max Planck Research School for Molecular and Cellular Life Sciences, Am Klopferspitz 18, 82152 Martinsried, Germany; Center for Integrated Protein Science Munich (CIPSM), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany. Electronic address: andreas.ladurner@med.lmu.de.
Andreas G
AG
Ladurner
D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics* / Q000378:metabolism*; D016922:Cellular Senescence / Q000235:genetics* / Q000502:physiology*; D006657:Histones / Q000235:genetics* / Q000378:metabolism*; D006801:Humans
D006657:Histones; D064007:Ataxia Telangiectasia Mutated Proteins