Multifocal Fibrosclerosis with Hypertrophic Pachymeningitis and a Soft Tissue Mass around the Thoracic Vertebral Bodies: A Case Report with Review of the Literature.
Multifocal fibrosclerosis is the term used to represent a combination of similar fibrous lesions occurring at different anatomical sites. We herein report a hypertrophic pachymeningitis patient with a soft tissue mass around the thoracic vertebral bodies. A histopathological analysis of the biopsied tissues from both lesions showed dense fibrosis and a marked infiltration of lymphocytes and plasma cells, which lead to the diagnosis of multifocal fibrosclerosis. This pathological condition closely resembles that of IgG4-related disease and is a very rare combination of manifestations. Our case suggests that hypertrophic pachymeningitis patients need to also undergo a whole body examination.
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Mitsuto
M
Sato
Minori
M
Kodaira
Wataru
W
Ishii
Michitaka
M
Nakagawa
Dai
D
Kishida
Daigo
D
Miyazaki
Yasuhiro
Y
Shimojima
Masayuki
M
Matsuda
Takeshi
T
Uehara
Shu-ichi
S
Ikeda
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006801:Humans; D006984:Hypertrophy / Q000175:diagnosis; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008581:Meningitis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D010950:Plasma Cells / Q000473:pathology; D012185:Retroperitoneal Fibrosis / Q000150:complications / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D016559:Tacrolimus / Q000627:therapeutic use; D013904:Thoracic Vertebrae / Q000473:pathology; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D016559:Tacrolimus; D008775:Methylprednisolone