[Collision Lung Cancer Consisting of Squamous Cell Carcinoma and Adenocarcinoma which Showed Identical Epidermal Growth Factor Receptor Mutation;Report of a Case].
We report a 79-year-old woman with collision cancer in the right middle lobe of the lung. She had a persistent abnormal shadow after treatment for pneumonia pointed out in right middle lung field on chest radiogram, and referred to our hospital. On examination, the chest computed tomography showed a pure-solid mass of 7.6 cm in diameter in right middle lobe of the lung which was thought to invade the superior pulmonary vein. She underwent a successful right pneumonecomty, and the postoperative course was uneventful. The tumor proved to be a collision cancer consisting of poor differentiated squamous cell carcinoma and invasive adenocarcinoma, lepidic predominanat by pathological examination. Epidermal growth factor receptor mutations (L858R) were found in both squamous cell carcinoma and adenocarcinoma of the tumor, possibly suggesting the same origin of both histological types.
Department of Surgery, Kumamoto Minami National Hospital, Uki, Japan.
Yutaka
Y
Motomura
Takeshi
T
Mori
Satoshi
S
Furuhashi
Naoko
N
Hayashi
Tomoko
T
Suzumura
Tohru
T
Yamanaka
Osamu
O
Sakamoto
Kazumi
K
Kuriwaki
Keiichiro
K
Kanemitsu
Makoto
M
Suzuki