High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7μm.
Intravascular photoacoustic imaging at 1.7μm spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacoustic/intravascular ultrasound (IVPA/IVUS) imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A lipid-mimicking phantom and atherosclerotic rabbit abdominal aorta were imaged at 1 frame per second, which is two orders of magnitude faster than previously reported in IVPA imaging with the same wavelength. Clear photoacoustic signals by the absorption of lipid rich deposition demonstrated the ability of the system for high speed vulnerable atherosclerotic plaques detection.
Zhonglie
Z
Piao
Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California , Los Angeles, California 90089, USA.
Teng
T
Ma
Beckman Laser Institute, Department of Biomedical Engineering, University of California , Irvine, Irvine, California 92612, USA.
Jiawen
J
Li
Beckman Laser Institute, Department of Biomedical Engineering, University of California , Irvine, Irvine, California 92612, USA.
Maximilian T
MT
Wiedmann
Beckman Laser Institute, Department of Biomedical Engineering, University of California , Irvine, Irvine, California 92612, USA.
Shenghai
S
Huang
Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California , Los Angeles, California 90089, USA.
Mingyue
M
Yu
Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California , Los Angeles, California 90089, USA.
K
K
Kirk Shung
Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California , Los Angeles, California 90089, USA.
Qifa
Q
Zhou
Department of Cogno-Mechatronics Engineering, Pusan National University , Busan 609-735, South Korea.
Chang-Seok
CS
Kim
Beckman Laser Institute, Department of Biomedical Engineering, University of California , Irvine, Irvine, California 92612, USA.
Zhongping
Z
Chen