Copper-catalyzed N-methylation/ethylation of sulfoximines.
A protocol for the copper-catalyzed N-methylation of sulfoximines with di-tert-butyl peroxide (DTBP) was developed. This protocol has good functional group tolerance leading to N-methylated sulfoximines in moderate to good yields. Besides, N-ethylation of sulfoximines was achieved in the presence of bis(1,1-dimethylpropyl)peroxide as the ethylating agent under a standard procedure.
School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China. yujintao@cczu.edu.cn.
Fan
F
Teng
Jiang
J
Cheng
Jin-Tao
JT
Yu
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008745:Methylation; D010545:Peroxides / Q000737:chemistry*; D013457:Sulfur Compounds / Q000737:chemistry*
D010545:Peroxides; D013457:Sulfur Compounds; C111570:di-tert-butyl peroxide; D003300:Copper