Novel microemulsion-based gel formulation of tazarotene for therapy of acne.
The objective of this study was to develop and evaluate a novel microemulsion based gel formulation containing tazarotene for targeted topical therapy of acne. Psudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant, and co-surfactant for microemulsion formation. The optimized microemulsion formulation containing 0.05% tazarotene was formulated by spontaneous microemulsification method consisting of 10% Labrafac CC, mixed emulsifiers 15% Labrasol-Cremophor-RH 40 (1:1), 15% Capmul MCM, and 60% distilled water (w/w) as an external phase. All plain and tazarotene-loaded microemulsions were clear and showed physicochemical parameters for desired topical delivery and stability. The permeation profiles of tazarotene through rat skin from optimized microemulsion formulation followed the Higuchi model for controlled permeation. Microemulsion-based gel was prepared by incorporating Carbopol®971P NF in optimized microemulsion formulation having suitable skin permeation rate and skin uptake. Microemulsion-based gel showed desired physicochemical parameters and demonstrated advantage over marketed formulation in improving the skin tolerability of tazarotene indicating its potential in improving its topical delivery. The developed microemulsion-based gel may be a potential drug delivery vehicle for targeted topical delivery of tazarotene in the treatment of acne.
a Department of Pharmaceutics and Pharmaceutical Technology , Indukaka Ipcowala College of Pharmacy , New Vallabh Vidyanagar , Gujarat , India.
Mrunali Rashmin
MR
Patel
b Department of Pharmaceutical Chemistry and Quality Assurance and.
Rashmin Bharatbhai
RB
Patel
c Department of Pharmaceutics and Pharmaceutical Technology , A.R. College of Pharmacy and G. H. Patel Institute of Pharmacy , Vallabh Vidyanagar , Gujarat , India , and.
Jolly R
JR
Parikh
d Department of Pharmacology , Charotar University of Science and Technology , Changa , Gujarat , India.
Bharat G
BG
Patel
D000152:Acne Vulgaris / Q000188:drug therapy*; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods; D004355:Drug Stability; D004655:Emulsions / Q000008:administration & dosage* / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D005782:Gels / Q000008:administration & dosage* / Q000737:chemistry*; D008297:Male; D009539:Nicotinic Acids / Q000008:administration & dosage* / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects; D013501:Surface-Active Agents / Q000737:chemistry; D012176:Retinoids
D004655:Emulsions; D005079:Excipients; D005782:Gels; D009539:Nicotinic Acids; D013501:Surface-Active Agents; C086827:tazarotene; D012176:Retinoids
Acne; microemulsion; skin irritation study; skin retention study; tazarotene; topical drug delivery