Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status.
Resistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and clinical datas. Thyroid nodule was palpated on physical examination. Thyroid ultrasonography showed multiple nodules in both lobes. Total thyroidectomy was performed. The pathological findings were consistent with papillary thyroid microcarcinoma. BRAFV600E mutation analysis results were negative. RTH is very rare and might be overlooked. There is no consensus on how to overcome the persistently high TSH in patients with RTH and differentiated thyroid cancer (DTC). Further studies are needed to explain the relationship between RTH and DTC which might be helpful for the treatment of these patients.
Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TR.
Melia
M
Karakose
Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TR.
Mustafa
M
Caliskan
Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TR.
Muyesser Sayki
MS
Arslan
Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TR.
Erman
E
Cakal
Department of Stem Cell and Genetic Diagnostic Center, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TR.
Ahmet
A
Yesilyurt
Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TR.
Tuncay
T
Delibasi
D000328:Adult; D002291:Carcinoma, Papillary / Q000150:complications / Q000235:genetics / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D018382:Thyroid Hormone Resistance Syndrome / Q000150:complications / Q000235:genetics / Q000601:surgery; D013964:Thyroid Neoplasms / Q000150:complications / Q000235:genetics / Q000601:surgery; D013965:Thyroidectomy