Validation of ethnopharmacological uses of Murraya paniculata in disorders of diarrhea, asthma and hypertension.
BACKGROUND
Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and cardiovascular problems.


METHODS
Aqueous-ethanolic extract of Mp.Cr was tested using in vitro techniques on isolated tissue of rabbit (jejunum, trachea and aorta) to detect the possible presence of spasmolytic activity. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system.


RESULTS
Application of the extract of Mp.Cr relaxed spontaneous and high K(+) (80mM)-induced contraction in rabbit jejunum preparation. Because it shifted the CRCs (Calcium response curve) towards the right side so the possible blockade was of calcium channel similar to verapamil. In rabbit trachea, extract of Mp.Cr produced relaxation of carbachol and high K(+) induced contractions. When plant extract was checked further on isolated aorta for its possible vasodilator effect, it caused relaxation of phenylephrine and high K(+)-induced spastic contractions at different doses.


CONCLUSIONS
These results indicate that Murraya paniculata shows anti-spasmodic, bronchodilator and vasodilator activity facilitated through Ca(++) antagonist mechanisms.
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. fatima2saqib@yahoo.com.
Fatima
F
Saqib
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. mobiii.ahmed@yahoo.com.
Mobeen Ghulam
MG
Ahmed
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. khjanbaz@hotmail.com.
Khalid Hussain
KH
Janbaz
Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India. s.dewanjee@yahoo.com.
Saikat
S
Dewanjee
Department of Crop Science, Faculty of Agriculture, University Putra Malaysia, Selangor, Malaysia. hawazej@gmail.com.
Hawa Z E
HZ
Jaafar
The Patent Office, Karachi, Pakistan. ahirzia@gmail.com.
Muhammad
M
Zia-Ul-Haq
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001249:Asthma / Q000378:metabolism*; D001337:Autonomic Agents / Q000494:pharmacology*; D003967:Diarrhea / Q000378:metabolism*; D020834:Ethnopharmacology; D006973:Hypertension / Q000378:metabolism*; D007583:Jejunum / Q000187:drug effects; D008954:Models, Biological; D032101:Murraya / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D014132:Trachea / Q000187:drug effects
D001337:Autonomic Agents; D010936:Plant Extracts