Prevalence of neurogenetic disorders in the North of England.
OBJECTIVE
Genetic disorders enter the differential diagnosis of common neurologic diseases, but their overall prevalence is not known. We set out to determine their minimum prevalence.


METHODS
Meta-analysis of epidemiologic data gathered from the same geographic region in the North of England.


RESULTS
Monogenic neurologic disorders affect at least 90.9/100,000 (95% confidence interval 87.6-94.3), or 1 in 1,100 of the population in Northern England.


CONCLUSIONS
As a group, neurogenetic disorders are not rare. These findings have implications for clinical service delivery.
From the Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
David
D
Bargiela
From the Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Patrick
P
Yu-Wai-Man
From the Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Michael
M
Keogh
From the Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Rita
R
Horvath
From the Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. patrick.chinnery@ncl.ac.uk.
Patrick F
PF
Chinnery
D004739:England / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D028361:Mitochondrial Diseases / Q000150:complications / Q000235:genetics; D009069:Movement Disorders / Q000453:epidemiology*; D009154:Mutation / Q000235:genetics*; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000235:genetics*; D015995:Prevalence