Correlations among copeptin, ischemia-modified albumin, and the extent of myocardial injury in patients with acute carbon monoxide poisoning.
This study evaluated the relationships among copeptin, ischemia-modified albumin (IMA), and extent of myocardial injury in patients with acute carbon monoxide poisoning (ACOP). A total of 110 patients with different degrees of ACOP were selected as the poisoning group, and 30 healthy individuals as the control group. The levels of troponin I (cTnI), IMA, and copeptin were detected. Based on the presence of complications, the patients were assigned to the complication (26 patients) or non-complication (84 patients) group. Levels of cTnI, IMA, and copeptin were compared among the control, complication, and non-complication groups. Compared with the control group, in the 2 h after admission, the IMA levels decreased and copeptin levels increased in the poisoning group; these changes were more significant in patients with severe ACOP than in those with mild ACOP, and the difference was statistically significant (P < 0.05). There were no differences in the IMA and copeptin levels between the groups 7 days after admission; the cTnI levels increased more significantly in patients with severe ACOP than in patients with mild and moderate ACOP, and the differences were statistically significant (P < 0.05). In the complication group, at 7 days after admission, the IMA levels decreased whereas the copeptin and cTnI levels were significantly higher than in the non-complication group, with a statistically significant difference (P < 0.05). IMA was negatively correlated with copeptin. IMA and copeptin detection is clinically useful in the early diagnosis and prognosis of ACOP-related myocardial injury and in guiding early clinical drug application.
Department of Emergency, Harrison International Peace Hospital, Hengshui, China.
J
J
Li
Department of Emergency, Harrison International Peace Hospital, Hengshui, China.
J S
JS
Wang
Department of Emergency, Harrison International Peace Hospital, Hengshui, China.
Z X
ZX
Xie
Department of Emergency, Harrison International Peace Hospital, Hengshui, China.
W Z
WZ
Wang
Department of Emergency, Harrison International Peace Hospital, Hengshui, China.
L
L
Wang
Department of Emergency, Harrison International Peace Hospital, Hengshui, China.
G Y
GY
Ma
Department of Emergency, Harrison International Peace Hospital, Hengshui, China.
Y Q
YQ
Li
Department of Emergency, Harrison International Peace Hospital, Hengshui, China.
P
P
Wang
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002249:Carbon Monoxide Poisoning / Q000378:metabolism*; D005260:Female; D006020:Glycopeptides / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D012709:Serum Albumin / Q000378:metabolism*; D000075462:Serum Albumin, Human; D019210:Troponin I; D055815:Young Adult
D015415:Biomarkers; D006020:Glycopeptides; D012709:Serum Albumin; D019210:Troponin I; C048197:copeptins; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human