SUMO-regulated transcription: challenging the dogma.
The small ubiquitin-like modifier SUMO regulates many aspects of cellular physiology to maintain cell homeostasis, both under normal conditions and during cell stress. Components of the transcriptional apparatus and chromatin are among the most prominent SUMO substrates. The prevailing view is that SUMO serves to repress transcription. However, as we will discuss in this review, this model needs to be refined, because recent studies have revealed that SUMO can also have profound positive effects on transcription.
Department of Molecular Biology, Institute of Microbiology, Oslo University Hospital, Oslo, Norway.
Pierre
P
Chymkowitch
Department of Molecular Biology, Institute of Microbiology, Oslo University Hospital, Oslo, Norway.
Aurélie
A
Nguéa P
Department of Molecular Biology, Institute of Microbiology, Oslo University Hospital, Oslo, Norway.
Jorrit M
JM
Enserink
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008239:Lysine / Q000378:metabolism; D011485:Protein Binding / Q000235:genetics; D011487:Protein Conformation; D025842:SUMO-1 Protein / Q000502:physiology*; D058207:Sumoylation / Q000502:physiology; D014158:Transcription, Genetic
D025842:SUMO-1 Protein; D008239:Lysine
RNA polymerase III; SUMO; UBLs; ribosomal proteins; stress response; tRNA; transcription