Impairment of exploratory behavior and spatial memory in adolescent rats in lithium-pilocarpine model of temporal lobe epilepsy.
Cognitive impairment in six-week -old rats has been studied in the lithium-pilocarpine model of adolescent temporal lobe epilepsy in humans. The pilocarpine-treated rats (n =21) exhibited (a) a decreased exploratory activity in comparison with control rats (n = 20) in the open field (OP) test and (b) a slower extinction of exploratory behavior in repeated OP tests. The Morris Water Maze (MWM) test showed that the effect of training was less pronounced in the pilocarpine-treated rats, which demonstrated disruption of predominantly short-term memory. Therefore, our study has shown that lithium-pilocarpine seizures induce substantial changes in exploratory behavior and spatial memory in adolescent rats. OP and MWM tests can be used in the search of drugs reducing cognitive impairments associated with temporal lobe epilepsy.
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
S V
SV
Kalemenev
O E
OE
Zubareva
E V
EV
Frolova
V V
VV
Sizov
V V
VV
Lavrentyeva
N Ya
NY
Lukomskaya
K Kh
KKh
Kim
A V
AV
Zaitsev
L G
LG
Magazanik
D000293:Adolescent; D000818:Animals; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000139:chemically induced / Q000503:physiopathology*; D005106:Exploratory Behavior / Q000187:drug effects*; D006801:Humans; D018020:Lithium Compounds; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000503:physiopathology*; D001523:Mental Disorders / Q000139:chemically induced* / Q000503:physiopathology; D010862:Pilocarpine; D051381:Rats; D017208:Rats, Wistar; D065852:Spatial Memory / Q000187:drug effects*
D018020:Lithium Compounds; D010862:Pilocarpine