Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts.
Hypertrophic cardiomyopathy is the most common monogenic disorder in cardiology. Despite important advances in understanding disease pathogenesis, it is not clear how flaws in individual sarcomere components are responsible for the observed phenotype. The aim of this article is to provide a brief interpretative analysis of some currently proposed pathophysiological mechanisms of hypertrophic cardiomyopathy, with a special emphasis on alterations in the cardiac mechanical properties.
Laboratory of Biological Chemistry, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece ; Department of Cardiology, AHEPA University Hospital Thessaloniki, Greece.
Dimitrios
D
Ntelios
Laboratory of Biological Chemistry, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Georgios
G
Tzimagiorgis
Department of Cardiology, AHEPA University Hospital Thessaloniki, Greece.
Georgios K
GK
Efthimiadis
Department of Cardiology, AHEPA University Hospital Thessaloniki, Greece.
Haralambos
H
Karvounis
LVOT obstruction; cardiac mechanics; epicardial-endocardial synergy; hypertrophic cardiomyopathy; myocardial disarray; stretch activation