Pattern of dyslipidaemia and impact of increasing age and duration of type 2 diabetes mellitus on dyslipidaemia, insulin levels and insulin resistance.
OBJECTIVE
To study the pattern of dyslipidaemia in Type 2 Diabetes Mellitus patients and to determine the correlation of increasing age and duration of the disease with dyslipidaemia, insulin level and insulin resistance in diabetic patients.


METHODS
The cross-sectional case-control study was conducted at Combined Military Hospital, Rawalpindi, and Centre for Research in Experimental and Applied Medicine, Army Medical College, Rawalpindi, Pakistan from June 2011 to June 2012, and comprised patients of type 2 diabetes mellitus and healthy controls. Serum levels of total cholesterol, triglycerides, low density lipoprotein, high-density lipoprotein and insulin in both the cases and the controls. Insulin resistance was calculated by Homeostatic Model of Assessment of insulin resistance. Correlation between increasing age and duration of the disease was determined using biochemical parameters. SPSS 17 was used for statistical analysis.


RESULTS
Of the 112 subjects in the study, 72(64%) were patients and 40(36%) were healthy controls. Among the cases, hypertriglyceridaemia was the commonest in 44(61%) followed by low-density-lipoprotein-hypercholesterolaemia 36(50%). Among the controls, 20(50%) subjects had low-density-lipoprotein-hypercholesterolaemia, followed by hypertriglyceridaemia in 17(42.5%). Duration of the disease was not found to be correlated with dyslipidaemia or insulin resistance (p>0.05). There was strong negative correlation of duration of the disease with serum insulin levels (p=0.03). Age showed no significant correlation with dyslipidaemia, serum insulin levels or insulin resistance on regression analysis (p>0.05 each).


CONCLUSIONS
In type diabetes mellitus, hypertriglyceridaemia was the commonest dyslipidaemia whereas hypercholesterolaemia was a risk factor in healthy individuals. Besides, the duration of disease was inversely correlated with serum insulin levels and positively correlated with dyslipidaemia.
Department of Physiology, Army Medical College, National University of Sciences and Technology, Rawalpindi, Pakistan.
Amina
A
Nadeem
Department of Physiology, College of Medicine, University of Dammam, Kingdom of Saudi Arabia.
Sadaf
S
Mumtaz
Department of Biochemistry, Army Medical College, National University of Sciences and Technology, Rawalpindi, Pakistan.
Abdul Khaliq
AK
Naveed
University of Health Sciences, Lahore, Pakistan.
Muhammad
M
Aslam
Physiology, Islamic Medical College, Rifah University, Rawalpindi, Pakistan.
Arif
A
Siddiqui
Physiology, Al-Nafees Medical College, Isra University, Islamabad, Pakistan.
Ghulam Mustafa
GM
Lodhi
D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D050171:Dyslipidemias / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D012307:Risk Factors
Diabetes mellitus, Dyslipidaemias, Insulin resistance.