Mold-Based Application of Laser-Induced Periodic Surface Structures (LIPSS) on Biomaterials for Nanoscale Patterning.
Laser-induced periodic surface structures (LIPSS) are highly regular, but at the same time contain a certain level of disorder. The application of LIPSS is a promising method to functionalize biomaterials. However, the absorption of laser energy of most polymer biomaterials is insufficient for the direct application of LIPSS. Here, we report the application of LIPSS to relevant biomaterials using a two-step approach. First, LIPSS are fabricated on a stainless steel surface. Then, the structures are replicated onto biomaterials using the steel as a mold. Results show that LIPSS can be transferred successfully using this approach, and that human mesenchymal stromal cells respond to the transferred structures. With this approach, the range of biomaterials that can be supplied with LIPSS increases dramatically.
Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, 7500 AE, The Netherlands.
Wim
W
Hendrikson
Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, 7500 AE, The Netherlands.
Wendy
W
Masman-Bakker
Department of Biomaterials Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, 7500 AE, The Netherlands.
Bas
B
van Bochove
Department of Applied Laser Technology, Faculty of Engineering Technology, University of Twente, Enschede, 7500 AE, The Netherlands.
Johann
J
Skolski
Department of Applied Laser Technology, Faculty of Engineering Technology, University of Twente, Enschede, 7500 AE, The Netherlands.
Justus
J
Eichstädt
Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, 7500 AE, The Netherlands.
Bart
B
Koopman
Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, 7500 AE, The Netherlands.|Complex Tissue Regeneration Department, MERLN Institute for Technology Inspired Regenerative Medicine, University of Maastricht, Maastricht, 6229 ER, The Netherlands.
Clemens
C
van Blitterswijk
Department of Biomaterials Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, 7500 AE, The Netherlands.|Department of Biomedical Engineering, W. J. Kolff Institute, UMC Groningen, Groningen, 9700 AN, The Netherlands.
Dirk
D
Grijpma
Department of Applied Laser Technology, Faculty of Engineering Technology, University of Twente, Enschede, 7500 AE, The Netherlands.
Gert-Willem
GW
Römer
Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, 7500 AE, The Netherlands.|Complex Tissue Regeneration Department, MERLN Institute for Technology Inspired Regenerative Medicine, University of Maastricht, Maastricht, 6229 ER, The Netherlands.
Lorenzo
L
Moroni
Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, 7500 AE, The Netherlands. j.rouwkema@utwente.nl.
Jeroen
J
Rouwkema
D001672:Biocompatible Materials; D002478:Cells, Cultured; D006801:Humans; D007834:Lasers; D059630:Mesenchymal Stem Cells; D049329:Nanostructures; D013193:Stainless Steel; D013499:Surface Properties
D001672:Biocompatible Materials; D013193:Stainless Steel
human mesenchymal stromal cells; laser-induced periodic surface structures; nanoscale; polymeric biomaterials