Lipase member H frequently overexpressed in human esophageal adenocarcinomas.
Esophageal cancer is one of the most frequent causes of cancer-related deaths worldwide. This is due to its asymptomatic nature or mild nonspecific symptoms. Most patients are diagnosed after appearance of prominent symptoms, and tumors are frequently accompanied by severe infiltration. Therefore, molecular biomarkers for the prognosis of early-stage esophageal cancer are desired. In this study, we examined the prognostic potential of lipase H (LIPH), a recently reported biomarker for lung adenocarcinoma and squamous carcinoma. We found that LIPH mRNA is also frequently upregulated in esophageal adenocarcinoma. Immunohistochemical analysis confirmed LIPH protein expression in various esophageal tumor tissue sections. Interestingly, higher expression of LIPH in esophageal adenocarcinoma showed a positive correlation with longer survival of patients. Our data suggest that LIPH may have prognostic value for esophageal cancer.
Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Hisako
H
Ishimine
Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.|Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, China.
Rui
R
Zhou
Department of Internal Medicine, JA Kochi Hospital, Kochi, Japan.
Kenya
K
Sumitomo
Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Yoshimasa
Y
Ito
Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Yasuhiro
Y
Seki
Department of Surgery, Asahi General Hospital, Chiba, Japan.
Yukihiro
Y
Yoshida
Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan. a-kurisaki@aist.go.jp.|Graduate School of Life and Environmental Sciences, The University of Tsukuba, Tsukuba, Ibaraki, Japan. a-kurisaki@aist.go.jp.
Akira
A
Kurisaki
D000230:Adenocarcinoma / Q000201:enzymology* / Q000401:mortality; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000201:enzymology* / Q000401:mortality; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008049:Lipase / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D046888:Tissue Array Analysis; D059467:Transcriptome
D014408:Biomarkers, Tumor; C504173:LIPC protein, human; D008049:Lipase
Esophageal adenocarcinoma; Esophageal squamous cell carcinoma; Lipase member H; Prognostic marker