Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing.
In this short summary we summarize some of the latest developments in vibrational spectroscopic tools applied for the sensing of (small) molecules and biomolecules in a label-free mode of operation. We first introduce various concepts for the enhancement of InfraRed spectroscopic techniques, including the principles of Attenuated Total Reflection InfraRed (ATR-IR), (phase-modulated) InfraRed Reflection Absorption Spectroscopy (IRRAS/PM-IRRAS), and Surface Enhanced Infrared Reflection Absorption Spectroscopy (SEIRAS). Particular attention is put on the use of novel nanostructured substrates that allow for the excitation of propagating and localized surface plasmon modes aimed at operating additional enhancement mechanisms. This is then be complemented by the description of the latest development in Surface- and Tip-Enhanced Raman Spectroscopies, again with an emphasis on the detection of small molecules or bioanalytes.
UPMC Univ Paris 6, UMR CNRS 7197, Laboratoire de Réactivité de Surface, 4 Place Jussieu, F-75005 Paris, France. souhir.boujday@upmc.fr.|CNRS, UMR 7197, Laboratoire de Réactivité de Surface, F-75005 Paris, France. souhir.boujday@upmc.fr.|Center for Biomimetic Sensor Science, 50 Nanyang Drive, Singapore 637553, Singapore. souhir.boujday@upmc.fr.
Souhir
S
Boujday
Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS, (UMR 7244), 74 rue Marcel Cachin, F-93017 Bobigny, France. marc.lamydelachapelle@univ-paris13.fr.
Marc Lamy
ML
de la Chapelle
AIT Austrian Institute of Technology, Donau City Strasse 1, A-1220 Vienna, Austria. johannes.srajer@ait.ac.at.
Johannes
J
Srajer
Center for Biomimetic Sensor Science, 50 Nanyang Drive, Singapore 637553, Singapore. wolfgang.knoll@ait.ac.at.|AIT Austrian Institute of Technology, Donau City Strasse 1, A-1220 Vienna, Austria. wolfgang.knoll@ait.ac.at.
Wolfgang
W
Knoll
D001564:Benzo(a)pyrene / Q000032:analysis; D015374:Biosensing Techniques / Q000379:methods*; D004784:Environmental Monitoring / Q000379:methods; D008956:Models, Chemical; D013055:Spectrophotometry, Infrared / Q000379:methods*; D014732:Vibration
D001564:Benzo(a)pyrene
IRRAS; SERS; biosensors; enhanced spectroscopies; infrared; plasmonic