Cancer Metastasis: Perivascular Macrophages Under Watch.
TIE2-expressing macrophages cluster around blood vessels and sustain tumor angiogenesis. Harney and colleagues now use live imaging of mouse mammary tumors to show that these perivascular macrophages also promote the transient opening of tumor blood vessels to facilitate hematogenous cancer cell dissemination and metastasis.
Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Ece
E
Kadioglu
Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. michele.depalma@epfl.ch.
Michele
M
De Palma
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects*; D005260:Female; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D057054:Molecular Imaging; D042787:Receptor, TIE-2 / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000494:pharmacology*
D042461:Vascular Endothelial Growth Factor A; D042787:Receptor, TIE-2