Polymeric and Solid Lipid Nanoparticles for Sustained Release of Carbendazim and Tebuconazole in Agricultural Applications.
Carbendazim (MBC) (methyl-2-benzimidazole carbamate) and tebuconazole (TBZ) ((RS)-1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol) are widely used in agriculture for the prevention and control of fungal diseases. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of bioactive compounds and their transfer to the site of action, reduced losses due to leaching or degradation, and decreased toxicity in the environment and humans. The objective of this study was to prepare these two types of nanoparticle as carrier systems for a combination of TBZ and MBC, and then investigate the release profiles of the fungicides as well as the stabilities and cytotoxicities of the formulations. Both nanoparticle systems presented high association efficiency (>99%), indicating good interaction between the fungicides and the nanoparticles. The release profiles of MBC and TBZ were modified when the compounds were loaded in the nanoparticles, and cytotoxicity assays showed that encapsulation of the fungicides decreased their toxicity. These fungicide systems offer new options for the treatment and prevention of fungal diseases in plants.
Department of Environmental Engineering, State University of São Paulo (UNESP), Sorocaba, SP, Brazil.|Department of Biochemistry, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.
Estefânia Vangelie Ramos
EV
Campos
Department of Environmental Engineering, State University of São Paulo (UNESP), Sorocaba, SP, Brazil.
Jhones Luiz
JL
de Oliveira
Department of Biochemistry, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.
Camila Morais Gonçalves
CM
da Silva
Department of Biotechnology, University of Sorocaba, Sorocaba, SP, Brazil.
Mônica
M
Pascoli
Department of Biotechnology, University of Sorocaba, Sorocaba, SP, Brazil.
Tatiane
T
Pasquoto
Department of Biotechnology, University of Sorocaba, Sorocaba, SP, Brazil.
Renata
R
Lima
Institute of Environment &Sustainable Development, Banaras Hindu University, Varanasi, India.
P C
PC
Abhilash
Department of Environmental Engineering, State University of São Paulo (UNESP), Sorocaba, SP, Brazil.|Department of Biochemistry, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.
Leonardo Fernandes
LF
Fraceto
D000383:Agriculture; D001562:Benzimidazoles / Q000008:administration & dosage*; D002219:Carbamates / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004355:Drug Stability; D005659:Fungicides, Industrial / Q000008:administration & dosage*; D008055:Lipids; D008962:Models, Theoretical; D053769:Nanocapsules; D053758:Nanoparticles; D010316:Particle Size; D011108:Polymers; D014230:Triazoles / Q000008:administration & dosage*
D001562:Benzimidazoles; D002219:Carbamates; D003692:Delayed-Action Preparations; D005659:Fungicides, Industrial; D008055:Lipids; D053769:Nanocapsules; D011108:Polymers; D014230:Triazoles; C087114:tebuconazole; C006698:carbendazim