Comparison of intravoxel incoherent motion diffusion-weighted MR imaging with dynamic contrast-enhanced MRI for differentiating lung cancer from benign solitary pulmonary lesions.
BACKGROUND
To compare intravoxel incoherent motion (IVIM) and pharmacokinetic analysis dynamic contrast-enhanced MR imaging (DCE-MRI) in distinguishing lung cancer (LC) from benign solitary pulmonary lesions (SPL).


METHODS
This prospective study was approved by the institutional review board, and written informed consent was obtained. Eighty-one consecutive patients considered for SPL underwent DW-IVIM and DCE-3T MRI. ADC, D, D*, and f were calculated with mono- and bi-exponential models. K(trans) , kep , ve , and vp were calculated with the modified Tofts model. Receiver operating characteristic (ROC) analysis was constructed to determine the diagnostic performance of IVIM and DCE-MRI in discriminating LC from benignity.


RESULTS
There were 29 patients with a total of 48 benign SPL and 52 LCs: 4 small cell carcinomas (SCLC), 19 squamous cell carcinomas (SCC), and 29 adenocarcinomas (Adeno-Ca). Both Adeno-Ca (ADC: 1.19 ± 0.23 × 10(-3) mm(2) /s; D:1.12 ± 0.35 × 10(-3) mm(2) /s; ve :0.27 ± 0.13; K(trans) :0.24 ± 0.09 min(-1) ; kep :0.90 ± 0.45 min(-1) ) and SCC (1.13± 0.28 × 10(-3) mm(2) /s; 1.02 ± 0.32 10(-3) mm(2) /s; 0.32 ± 0.14; 0.26 ± 0.08 min(-1) ; 0.90 ± 0.48 min(-1) ) had significantly lower ADC, D, ve and larger K(trans) , kep than benignity (1.37 ± 0.38 × 10(-3) mm(2) /s; 1.34 ± 0.45 × 10(-3) mm(2) /s; 0.42 ± 0.19; 0.19 ± 0.08 min(-1) ; 0.53 ± 0.26 min(-1) ). D (72.2%) had significantly higher accuracy (72.2%) and higher sensitivity (91.3%) than other imaging indices (accuracy: 55.5-68.0%; sensitivity: 41.3-78.3%; all P < 0.01) except for accuracy in kep (70.8%; P > 0.05) in discriminating LC from benignity. K(trans) exhibited significantly higher specificity (84.6%) than the other indices (38.5-73.1%; P < 0.01). These results can be improved by combined D and K(trans) , leading to a sensitivity, specificity and accuracy of 94.2%, 92%, and 93.5%, respectively.


CONCLUSIONS
IVIM-derived D and DCE-derived K(trans) are two promising parameters for differentiating LC from benignity.
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Mei
M
Yuan
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yu-Dong
YD
Zhang
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chan
C
Zhu
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Tong-Fu
TF
Yu
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hai-Bin
HB
Shi
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhao-Fei
ZF
Shi
Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hai
H
Li
Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Jiang-Fen
JF
Wu
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D000368:Aged; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology; D002454:Cell Differentiation; D003287:Contrast Media / Q000737:chemistry*; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009038:Motion; D015588:Observer Variation; D010363:Pattern Recognition, Automated; D010477:Perfusion; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging* / Q000473:pathology
D003287:Contrast Media
diffusion-weighted imaging; dynamic contrast-enhanced MRI; magnetic resonance imaging; solitary pulmonary lesions