Molecular Mechanisms of Renal Ischemic Conditioning Strategies.
Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized.
Department of Clinical Medicine, Aarhus University Hospital, Skejby, Denmark.
Casper
C
Kierulf-Lassen
Gertrude J
GJ
Nieuwenhuijs-Moeke
Nicoline V
NV
Krogstrup
Mihai
M
Oltean
Bente
B
Jespersen
Frank J M F
FJ
Dor
D058186:Acute Kidney Injury / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D002986:Clinical Trials as Topic; D051799:Delayed Graft Function / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods* / Q000639:trends; D019194:Ischemic Preconditioning / Q000379:methods* / Q000639:trends; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D016030:Kidney Transplantation; D008954:Models, Biological; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control; D015398:Signal Transduction; D057170:Translational Research, Biomedical