Amantadine-Induced Livedo Racemosa.
Although livedo reticularis is a known adverse effect of amantadine, only limited studies have addressed this association. Livedo racemosa in contrast to livedo reticularis is characterized by a striking violaceous netlike pattern of the skin similar to livedo reticularis with a different histopathology and morphology (irregular, broken circular segments). In this case report, we present 2 cases of livedo racemosa and edema of lower extremities following amantadine treatment. The cutaneous biopsies in both cases showed intraluminal thrombi in subcutaneous blood vessels without evidence of vasculitis, which is consistent with livedo racemosa.
São Paulo University, São Paulo, Brazil.
Paulo Ricardo
PR
Criado
University of Toronto, Toronto, Ontario, Canada afsaneh.alavi@utoronto.ca.
Afsaneh
A
Alavi
São Paulo University, São Paulo, Brazil.
Neusa Yuriko Sakai
NY
Valente
São Paulo University, São Paulo, Brazil.
Mirian Nacagami
MN
Sotto
D000547:Amantadine / Q000009:adverse effects*; D000978:Antiparkinson Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D007866:Leg; D054068:Livedo Reticularis / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
D000978:Antiparkinson Agents; D000547:Amantadine
amantadine; livedo; livedo racemosa; livedo reticularis; vasculopathy