Update on Pharmacologic Retinal Vascular Toxicity.
Several medications are associated with retinal vascular toxicity. These include intraocular aminoglycosides, oral contraceptives, interferon alpha, several other agents, and talc, which occurs as a vehicle in some oral medications that may be abused intravenously. As a group, these entities represent a small but clinically relevant category of retinal toxicity from medications. Some of the manifestations (e.g., retinal vascular occlusion) are nonspecific, but others are more specific, including clinically visible talc emboli in retinal vessels. Toxicity may be asymptomatic or may cause irreversible visual loss. By maintaining a high index of suspicion, the correct diagnosis can usually be made.
Bascom Palmer Eye Institute, 3880 Tamiami Trail North, Naples, FL, 34103, USA. sschwartz2@med.miami.edu.
Stephen G
SG
Schwartz
Andrzej
A
Grzybowski
Weronika
W
Wasinska-Borowiec
Harry W
HW
Flynn
William F
WF
Mieler
D000617:Aminoglycosides / Q000633:toxicity*; D001766:Blindness / Q000139:chemically induced; D003276:Contraceptives, Oral / Q000633:toxicity*; D006801:Humans; D016898:Interferon-alpha / Q000633:toxicity*; D012170:Retinal Vein Occlusion / Q000139:chemically induced; D012171:Retinal Vessels / Q000187:drug effects*; D013627:Talc / Q000633:toxicity*
D000617:Aminoglycosides; D003276:Contraceptives, Oral; D016898:Interferon-alpha; D013627:Talc