Efficacy of Intravitreal Triamcinolone Acetonide for Diabetic Macular Edema After Vitrectomy.
OBJECTIVE
To compare the efficacy of intravitreal injection of triamcinolone acetonide (IVTA) for diabetic macular edema (DME) in vitrectomized eyes with DME without vitrectomy eyes.


METHODS
This retrospective comparative study evaluated the efficacy of IVTA treatment of DME in 26 consecutive eyes (23 patients). Changes in mean best-corrected visual acuity (VA) and mean central retinal thickness (CRT) were retrospectively evaluated before IVTA and during the 6-month period after IVTA.


RESULTS
Subjects were divided into 2 groups: 13 consecutive eyes (11 patients) with proliferative diabetic retinopathy or DME that underwent vitrectomy (vitrectomized group), and 13 consecutive eyes (12 patients) with DME who received IVTA, but did not undergo vitrectomy (nonvitrectomized group). In the vitrectomized group, there was a significantly decreased CRT for up to 4 months as compared to the thicknesses before IVTA. In the nonvitrectomized group, there was a significantly decreased CRT for up to 5 months after IVTA. In both groups, there was significant improvement in the VA for up to 4 months after IVTA.


CONCLUSIONS
IVTA may represent a valid treatment option for DME, even in vitrectomized eyes.
Department of Ophthalmology, The Jikei University School of Medicine , Tokyo, Japan .
Akira
A
Watanabe
Department of Ophthalmology, The Jikei University School of Medicine , Tokyo, Japan .
Akane
A
Tsuzuki
Department of Ophthalmology, The Jikei University School of Medicine , Tokyo, Japan .
Kota
K
Arai
Department of Ophthalmology, The Jikei University School of Medicine , Tokyo, Japan .
Tamaki
T
Gekka
Department of Ophthalmology, The Jikei University School of Medicine , Tokyo, Japan .
Kenichi
K
Kohzaki
Department of Ophthalmology, The Jikei University School of Medicine , Tokyo, Japan .
Hiroshi
H
Tsuneoka
D000328:Adult; D000368:Aged; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use*; D014821:Vitrectomy
D014222:Triamcinolone Acetonide