Central obesity is associated with non-cirrhotic portal vein thrombosis.
OBJECTIVE
30-40% of portal vein thrombosis (PVT) remains of unknown origin. An association between metabolic syndrome (MetS) and peripheral vein thrombosis has been reported but not with PVT, to date. The aim of this study was to investigate the association between MetS and PVT.


METHODS
Between 2003 and 2014, all consecutive patients with non-cirrhotic PVT were prospectively included. Patient's characteristics and risks factors were recorded at the time of inclusion. Controls were selected by random in the general population and were matched 1/1 according to age and sex.


RESULTS
Seventy-nine patients with PVT were included: 40 present with at least one risk factor for PVT (SPVT) and 39 were found to be idiopathic (IPVT). The prevalence of MetS was 25.6% in SPVT group vs. 47.4% in IPVT group and 17.9% in controls from the general population (C-IPVT: p=0.01). The waist circumference and body mass index were higher in the IPVT group than in the SPVT group (105 vs. 93cm, p=0.004 and 29.4 vs. 25.0kg/m(2), p=0.004) and in the C-IPVT group (105 vs. 92cm, p=0.001 and 29.4 vs. 25.8kg/m(2), p=0.003). Overweight was observed in 82.0% of patients in the IPVT group vs. 44% in the SPVT group (p=0.002) and 51% in the C-IPVT group (p=0.01). The mean visceral fat area was higher in IPVT than in SPVT (18,223mm(2)vs. 12,690mm(2), p=0.02). In multivariate analyses, an increase in waist circumference was the strongest parameter associated with idiopathic PVT.


CONCLUSIONS
Central obesity is associated with PVT and could become one of the main risk factors for digestive thromboses.
Service d'hépato-gastro-entérologie CHU Toulouse Hôpital Purpan et Université Paul Sabatier, Toulouse, France. Electronic address: bureau.c@chu-toulouse.fr.
Christophe
C
Bureau
Service d'hépato-gastro-entérologie CHU Toulouse Hôpital Purpan et Université Paul Sabatier, Toulouse, France.
Julie
J
Laurent
Service d'hépato-gastro-entérologie CHU Toulouse Hôpital Purpan et Université Paul Sabatier, Toulouse, France.
Marie Angèle
MA
Robic
Service d'hépato-gastro-entérologie CHU Toulouse Hôpital Purpan et Université Paul Sabatier, Toulouse, France.
Camille
C
Christol
Service d'hépato-gastro-entérologie CHU Toulouse Hôpital Purpan et Université Paul Sabatier, Toulouse, France.
Maeva
M
Guillaume
Department of Epidemiology, Health Economics and Public Health, UMR1027 INSERM-University of Toulouse III, Toulouse University Hospital (CHU), Toulouse, France.
Jean Bernard
JB
Ruidavets
Department of Cardiology B, Toulouse University Hospital, UMR1027 INSERM-University of Toulouse III, Toulouse University Hospital (CHU), Toulouse, France.
Jean
J
Ferrieres
Service d'hépato-gastro-entérologie CHU Toulouse Hôpital Purpan et Université Paul Sabatier, Toulouse, France.
Jean Marie
JM
Péron
Service d'hépato-gastro-entérologie CHU Toulouse Hôpital Purpan et Université Paul Sabatier, Toulouse, France.
Jean Pierre
JP
Vinel
D000328:Adult; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000627:therapeutic use; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000175:diagnosis / Q000453:epidemiology; D011169:Portal Vein; D015995:Prevalence; D012307:Risk Factors; D013223:Statistics as Topic; D020246:Venous Thrombosis / Q000175:diagnosis / Q000453:epidemiology; D055105:Waist Circumference
D003276:Contraceptives, Oral
Metabolic syndrome; Obesity; Portal vein thrombosis; Risk factor