Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection.
OBJECTIVE
This study aimed to evaluate antenatal risk factors associated with symptomatic congenital cytomegalovirus (CMV) disease, following in utero vertical infection.


METHODS
This study included a retrospective cohort of 155 neonates with congenital CMV infection, following primary maternal CMV infection during pregnancy, and were divided to symptomatic (n=95) and asymptomatic (n=60) newborns.


RESULTS
Young maternal age (29.1±5.12 vs. 31.6±5.36 years, P=0.005), high risk occupation for viral exposure (20.0% vs. 11.7%, P=0.04), CMV IgG seroconversion at diagnosis (83.1% vs. 63.3%, P=0.005) and abnormal fetal MRI (11.6% vs. 0%, P=0.003) were found to be prognostic risk factors associated with symptomatic CMV disease of the newborn. Maternal febrile illness at diagnosis, IgG avidity, US findings and the timing of maternal infection were not associated with the occurrence of neonatal symptoms.


CONCLUSIONS
Knowledge of the reported risk factors may assist in counseling parents with intra uterine CMV infection.
Eran
E
Hadar
Liat
L
Salzer
Elizabeta
E
Dorfman
Jacob
J
Amir
Joseph
J
Pardo
D000328:Adult; D015331:Cohort Studies; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital / Q000635:transmission*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016216:Ultrasonography, Prenatal; D055815:Young Adult