Psoriasis-like lesions in a patient with familial Mediterranean fever.
Familial Mediterranean fever (FMF) is a rare hereditary autoinflammatory disorder that is caused by pyrin gene mutation associated with aberrance of the interleukin (IL)-1β pathway and characterized by recurrent, self-limiting attacks of fever and other inflammatory symptoms. We report a case of FMF with annular erythema and psoriasis-like lesions, the latter of which demonstrated parakeratosis with neutrophil microabscesses and mild inflammatory mononuclear cell infiltration in the upper dermis. Immunofluorescence staining showed IL-17-positive T-cells. Skin eruption with neutrophil migration in the epidermis may be provoked by T-helper 17 cell activation through the abnormal IL-1β cascade in FMF.
Department of Dermatology and Allergology, Nagasaki University Hospital, Nagasaki, Japan.
Miwa
M
Ashida
Department of Dermatology and Allergology, Nagasaki University Hospital, Nagasaki, Japan.
Yuta
Y
Koike
Department of Dermatology and Allergology, Nagasaki University Hospital, Nagasaki, Japan.
Sayaka
S
Kuwatsuka
Department of Immunology and Rheumatology, Nagasaki University Hospital, Nagasaki, Japan.
Kunihiro
K
Ichinose
Department of Rheumatology and Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Omura, Japan.
Kiyoshi
K
Migita
Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan.
Shigetoshi
S
Sano
Department of Dermatology and Allergology, Nagasaki University Hospital, Nagasaki, Japan.
Atsushi
A
Utani
D010505:Familial Mediterranean Fever / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D011565:Psoriasis / Q000209:etiology / Q000473:pathology*; D000071198:Pyrin / Q000235:genetics; D058504:Th17 Cells / Q000276:immunology / Q000473:pathology
C000604192:MEFV protein, human; D000071198:Pyrin
familial Mediterranean fever; interleukin-17; interleukin-1β; neutrophil; psoriasis-like lesions