Optic nerve involvement in childhood onset systemic lupus erythematosus: Three cases and a review of the literature.
The ocular system can be affected in systemic lupus erythematosus (SLE) in one third of patients. However, optic nerve involvement is relatively uncommon, but is more so in pediatric SLE patients, where it can occur in 1% of cases. We report three children with SLE who presented with optic nerve involvement. Two children had optic neuritis, with optic neuritis being the first manifestation in one child. The third child had ischaemic optic neuropathy secondary to antiphospholipid syndrome. A careful work up for SLE should be performed in every child with optic nerve disease. Prompt diagnosis and early treatment results in a better prognosis.
Pediatric Allergy Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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Suri
Pediatric Allergy Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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Abujam
Pediatric Allergy Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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Gupta
Pediatric Allergy Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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Rawat
Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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Saikia
Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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Walker Minz
Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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Gupta
Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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Bansal
Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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Kaushik
Pediatric Allergy Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India surjitsinghpgi@rediffmail.com.
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Singh
D000293:Adolescent; D017668:Age of Onset; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D009902:Optic Neuritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011237:Predictive Value of Tests; D012074:Remission Induction; D012307:Risk Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents
Childhood systemic lupus erythematosus; ischemic optic neuropathy