Association between a Genetic Variant in the hsa-miR-146a Gene and Cancer Risk: An Updated Meta-Analysis.
OBJECTIVE
A large number of studies have investigated the association between the potentially functional genetic variant rs2910164 located in the hsa-miR-146a gene and susceptibility to various types of cancer. Nevertheless, the results obtained in these studies are contradictory. Therefore, we conducted a meta-analysis of data from eligible reports comprising a total of 28,359 cases and 41,678 controls.


METHODS
The literature included in this meta-analysis was selected from the PubMed database. Quantitative data synthesis was performed by using the OpenMeta-analyst software.


RESULTS
The meta-analysis yielded no evidence of an association between rs2910164 and the overall cancer risk. Conversely, the C allele of this genetic variant was found to be associated with a decreased risk of developing bladder and cervical cancer in multiple genetic models. The same direction of association was found for the C allele and liver cancer, gastric cancer and oral squamous cell carcinoma risk. In contrast to these results, the same allelic variant of rs2910164 was found to confer an increased risk of developing lung cancer. The stratified meta-analysis based on ethnicity did not show significant differences in the association between rs2910164 and cancer risk in populations with different ethnic backgrounds.


CONCLUSIONS
We conclude that rs2910164 may represent a valuable biomarker associated with the risk of developing specific types of cancer.
Centre for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
Zorana Z
ZZ
Nikolić
Dušanka L
DL
Savić Pavićević
Nemanja L
NL
Vučic
Stanka P
SP
Romac
Goran N
GN
Brajušković
D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016208:Databases, Factual; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
D005819:Genetic Markers; C542542:MIRN146 microRNA, human; D035683:MicroRNAs