Essential oil composition and biological activity from Artemisia caerulescens subsp. densiflora (Viv.) Gamisans ex Kerguélen & Lambinon (Asteraceae), an endemic species in the habitat of La Maddalena Archipelago.
The purpose of this study was to investigate the composition of the essential oil obtained from a population of Artemisia caerulescens subsp. densiflora growing in Razzoli, an island in the La Maddalena Archipelago (Sardinia, Italy). A. caerulescens sups. densiflora Viv. (Asteraceae), a wild herb, seldom studied in the Mediterranean, represents one of the many rare endemic species growing in North Sardinia. The essential oil composition was analysed by means of GC/MS analysis, which showed davana ethers as the major volatile components, accounting together for 17.5%, followed by (E)-nerolidol (4.5%), β-oplopenone (3.3%), cis-sabinene hydrate (5.2%) and terpinen-4-ol (4.7%). The oil was tested for antioxidant activity by means of DPPH test, inhibition of lipid oxidation test and hypochlorous acid test, which showed a quite interesting scavenger capacity. For the first time, we reported the cytotoxic activity of the essential oil of A. caerulescens subsp. densiflora, against three human tumour cell lines (A375, MDA-MB231 and HCT116), with IC50 values in the range 5.20-7.61 μg/mL, which deserved further studies to support its use as chemopreventive agent. Finally, the antimicrobial activity of the essential oil, displayed on a panel of human pathogens, was very low.
a Dipartimento di Chimica , Università degli studi di Roma "La Sapienza" , Rome , Italy.|b Consorzio Interuniversitario Co.S.Me.Se.,Dipartimento di Scienze Botaniche , Università di Cagliari , Cagliari , Italy.
Luigi
L
Ornano
e Dipartimento di Biologia Ambientale , Università di Roma "La Sapienza" , Rome , Italy.
Alessandro
A
Venditti
b Consorzio Interuniversitario Co.S.Me.Se.,Dipartimento di Scienze Botaniche , Università di Cagliari , Cagliari , Italy.
Mauro
M
Ballero
b Consorzio Interuniversitario Co.S.Me.Se.,Dipartimento di Scienze Botaniche , Università di Cagliari , Cagliari , Italy.
Cinzia
C
Sanna
c Parco nazionale dell' Arcipelago di La Maddalena , La Maddalena, Sardinia , Italy.
Yuri
Y
Donno
d Scuola di Farmacia e dei Prodotti della Salute , Università di Camerino , Camerino , Italy.
Luana
L
Quassinti
d Scuola di Farmacia e dei Prodotti della Salute , Università di Camerino , Camerino , Italy.
Massimo
M
Bramucci
d Scuola di Farmacia e dei Prodotti della Salute , Università di Camerino , Camerino , Italy.
Luca A
LA
Vitali
h Scuola di Bioscienze e Medicina Veterinaria , Università di Camerino , Camerino , Italy.
Dezemona
D
Petrelli
f Dipartimento di Scienze BIomolecolari , Università di Urbino , Urbino , Italy.
Bruno
B
Tirillini
g Scuola di Scienze e Tecnologie , Università di Camerino , Camerino , Italy.
Fabrizio
F
Papa
d Scuola di Farmacia e dei Prodotti della Salute , Università di Camerino , Camerino , Italy.
Filippo
F
Maggi
a Dipartimento di Chimica , Università degli studi di Roma "La Sapienza" , Rome , Italy.|b Consorzio Interuniversitario Co.S.Me.Se.,Dipartimento di Scienze Botaniche , Università di Cagliari , Cagliari , Italy.
Armanodoriano
A
Bianco
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants; D019306:Artemisia / Q000737:chemistry*; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D017753:Ecosystem; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D020128:Inhibitory Concentration 50; D007558:Italy; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D009822:Oils, Volatile; D013729:Terpenes
(E)-nerolidol; Artemisia caerulescens subsp. densiflora Viv.; cis-sabinene; davana ethers; davanone; terpinen-4-ol; β-oplopenone