Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome Associated With Anti-N-methyl-D-aspartate Receptor Encephalitis.
BACKGROUND
The full clinical spectrum of anti-N-methyl-D-aspartate receptor encephalitis is unknown in the pediatric population.


METHODS
We describe a previously healthy 4-year-old girl presenting with opsoclonus-myoclonus together with ataxia who had NR1-specific, anti-N-methyl-D-aspartate receptor antibodies in the cerebral spinal fluid.


CONCLUSIONS
The presence of NR1-specific, anti-N-methyl-D-aspartate receptor antibodies in the setting of opsoclonus-myoclonus and ataxia syndrome may represent an expansion of the clinical presentations of anti-N-methyl-D-aspartate receptor encephalitis.
Pediatric Hospital Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: bplayer@mcw.edu.
Brittany
B
Player
Pediatric Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Matthew
M
Harmelink
Pediatric Hospital Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Brett
B
Bordini
Pediatric Hospital Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Michael
M
Weisgerber
Medical Education Office, Medical College of Wisconsin, Milwaukee, Wisconsin.
Michael
M
Girolami
Medical College of Wisconsin, Milwaukee, Wisconsin.
Michael
M
Croix
D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000188:drug therapy / Q000503:physiopathology*; D001323:Autoantibodies / Q000134:cerebrospinal fluid; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053578:Opsoclonus-Myoclonus Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology
D001323:Autoantibodies; C409466:NR1 NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate
anti-NMDA receptor; ataxia; encephalitis; myoclonus; opsoclonus-myoclonus-ataxia syndrome; paraneoplastic syndrome; pediatric