A nomogram to predict prognostic values of various inflammatory biomarkers in patients with esophageal squamous cell carcinoma.
BACKGROUND
Inflammation plays an important role in cancer progression and prognosis. However, the prognostic values of inflammatory biomarkers in esophageal cancer (EC) were not established. In the present study, therefore, we initially used a nomogram to predict prognostic values of various inflammatory biomarkers in patients with esophageal squamous cell carcinoma (ESCC).


METHODS
A total of 326 ESCC patients were included in this retrospective study. Glasgow prognostic score (GPS), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and lymphocyte monocyte ratio (LMR) were analyzed in the current study. Kaplan-Meier method was used to calculate the cancer-specific survival (CSS). Cox regression analysis was also performed to evaluate the prognostic factors. A nomogram was established to predict the prognosis for CSS.


RESULTS
Patients were divided into 3 groups according to GPS (GPS 0, 1 and 2) and 2 groups according to NLR (≤3.45 and >3.45), PLR (≤166.5 and >166.5) and LMR (≤2.30 and >2.30). The 5-year CSS in patients with GPS 0, 1 and 2 were 49.2%, 26.8% and 11.9%, respectively (P<0.001). In addition, patients with NLR (>3.45), PLR (>166.5) and LMR (≤2.30) were significantly associated with decreased CSS, respectively (P<0.001). Multivariate analysis revealed that GPS (P<0.001), PLR (P=0.002) and LMR (P=0.002) were independent prognostic factors in patients with ESCC. In addition, a nomogram was established according to all significantly independent factors for CSS. The Harrell's c-index for CSS prediction was 0.72.


CONCLUSIONS
GPS, PLR and LMR were potential prognostic biomarkers in patients with ESCC. The nomogram based on CSS could be used as an accurately prognostic prediction for patients with ESCC.
Department of Thoracic Surgery, Zhejiang Cancer Hospital No.38 Guangji Road, Banshan Bridge, Hangzhou 310022, China.
Jin-Shi
JS
Liu
Department of Operating Theatre, Zhejiang Cancer Hospital No.38 Guangji Road, Banshan Bridge, Hangzhou 310022, China.
Ying
Y
Huang
Department of Thoracic Surgery, Zhejiang Cancer Hospital No.38 Guangji Road, Banshan Bridge, Hangzhou 310022, China.
Xun
X
Yang
Department of Thoracic Surgery, Zhejiang Cancer Hospital No.38 Guangji Road, Banshan Bridge, Hangzhou 310022, China.
Ji-Feng
JF
Feng
Esophageal cancer; cancer-specific survival; nomogram; prognostic factor; squamous cell carcinoma