Vitamin D-Binding Protein in Health and Chronic Kidney Disease.
Vitamin D-binding protein (DBP) is a multifunctional protein that has attracted increasing interest in recent years, largely because of its potential role in modulating the activity of vitamin D. Nearly all circulating vitamin D (~85-90%) circulates bound to DBP, with a smaller proportion bound to albumin, leaving <5% circulating freely. DBP may also play roles beyond vitamin D binding, with potential roles in the immune system and elsewhere. Numerous polymorphisms of DBP exist around the world, and recent studies have identified relevance of different DBP phenotypes in determining DBP concentration and vitamin D affinity. This review focuses on the known roles of DBP in health and kidney disease, and current views on the relevance of DBP polymorphisms.
Departments of Pediatrics and Epidemiology, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Michelle R
MR
Denburg
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Ishir
I
Bhan
D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000235:genetics*; D014809:Vitamin D-Binding Protein / Q000097:blood / Q000235:genetics*
D014809:Vitamin D-Binding Protein