[Development of new vaccines].
Recent and important advances in the fields of immunology, genomics, functional genomics, immunogenetics, immunogenomics, bioinformatics, microbiology, genetic engineering, systems biology, synthetic biochemistry, proteomics, metabolomics and nanotechnology, among others, have led to new approaches in the development of vaccines. The better identification of ideal epitopes, the strengthening of the immune response due to new adjuvants, and the search of new routes of vaccine administration, are good examples of advances that are already a reality and that will favour the development of more vaccines, their use in indicated population groups, or its production at a lower cost. There are currently more than 130 vaccines are under development against the more wished (malaria or HIV), difficult to get (CMV or RSV), severe re-emerging (Dengue or Ebola), increasing importance (Chagas disease or Leishmania), and nosocomial emerging (Clostridium difficile or Staphylococcus aureus) infectious diseases.
Servicio de Microbiología Clínica, Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, España. Electronic address: fgromo@salud.madrid.org.
Fernando
F
González-Romo
Servicio de Microbiología Clínica, Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, España.
Juan J
JJ
Picazo
D000276:Adjuvants, Immunologic; D021821:Communicable Diseases, Emerging / Q000276:immunology / Q000517:prevention & control; D000939:Epitopes / Q000276:immunology; D006801:Humans; D011639:Public Opinion; D014611:Vaccination / Q000523:psychology / Q000639:trends; D014612:Vaccines / Q000009:adverse effects / Q000276:immunology; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic
D000276:Adjuvants, Immunologic; D000939:Epitopes; D014612:Vaccines; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic
Desarrollo de vacunas; Vaccines development; Vaccinology; Vacunología; Vacunomics; Vacunómica