Spatial variability in cortex-muscle coherence investigated with magnetoencephalography and high-density surface electromyography.
Cortex-muscle coherence (CMC) reflects coupling between magnetoencephalography (MEG) and surface electromyography (sEMG), being strongest during isometric contraction but absent, for unknown reasons, in some individuals. We used a novel nonmagnetic high-density sEMG (HD-sEMG) electrode grid (36 mm × 12 mm; 60 electrodes separated by 3 mm) to study effects of sEMG recording site, electrode derivation, and rectification on the strength of CMC. Monopolar sEMG from right thenar and 306-channel whole-scalp MEG were recorded from 14 subjects during 4-min isometric thumb abduction. CMC was computed for 60 monopolar, 55 bipolar, and 32 Laplacian HD-sEMG derivations, and two derivations were computed to mimic "macroscopic" monopolar and bipolar sEMG (electrode diameter 9 mm; interelectrode distance 21 mm). With unrectified sEMG, 12 subjects showed statistically significant CMC in 91-95% of the HD-sEMG channels, with maximum coherence at ∼25 Hz. CMC was about a fifth stronger for monopolar than bipolar and Laplacian derivations. Monopolar derivations resulted in most uniform CMC distributions across the thenar and in tightest cortical source clusters in the left rolandic hand area. CMC was 19-27% stronger for HD-sEMG than for "macroscopic" monopolar or bipolar derivations. EMG rectification reduced the CMC peak by a quarter, resulted in a more uniformly distributed CMC across the thenar, and provided more tightly clustered cortical sources than unrectifed sEMGs. Moreover, it revealed CMC at ∼12 Hz. We conclude that HD-sEMG, especially with monopolar derivation, can facilitate detection of CMC and that individual muscle anatomy cannot explain the high interindividual CMC variability.
Brain Research Unit, Department of Neuroscience and Biomedical Engineering, and MEG Core and Advanced Magnetic Imaging (AMI) Centre, Aalto NeuroImaging, Aalto University School of Science, Aalto, Espoo, Finland; and harri.piitulainen@aalto.fi.
Harri
H
Piitulainen
Laboratory of Engineering of Neuromuscular System and Motor Rehabilitation, Dipartimento di Elettronica e Telecomunicazioni, Politecnico di Torino, Turin, Italy.
Alberto
A
Botter
Brain Research Unit, Department of Neuroscience and Biomedical Engineering, and MEG Core and Advanced Magnetic Imaging (AMI) Centre, Aalto NeuroImaging, Aalto University School of Science, Aalto, Espoo, Finland; and.
Mathieu
M
Bourguignon
Brain Research Unit, Department of Neuroscience and Biomedical Engineering, and MEG Core and Advanced Magnetic Imaging (AMI) Centre, Aalto NeuroImaging, Aalto University School of Science, Aalto, Espoo, Finland; and.
Veikko
V
Jousmäki
Brain Research Unit, Department of Neuroscience and Biomedical Engineering, and MEG Core and Advanced Magnetic Imaging (AMI) Centre, Aalto NeuroImaging, Aalto University School of Science, Aalto, Espoo, Finland; and.
Riitta
R
Hari
D000328:Adult; D004576:Electromyography / Q000379:methods*; D005260:Female; D006225:Hand / Q000294:innervation / Q000502:physiology; D006801:Humans; D007537:Isometric Contraction; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D055815:Young Adult
corticomuscular coherence; magnetoencephalography; multichannel EMG; sensorimotor cortex; spatial filter