Tris(trimethylsilyl)silane and visible-light irradiation: a new metal- and additive-free photochemical process for the synthesis of indoles and oxindoles.
A combined tris(trimethylsilyl)silane and visible-light-promoted intramolecular reductive cyclization protocol for the synthesis of indoles and oxindoles has been developed. This straightforward and efficient method shows tolerance towards a broad spectrum of functional-groups and enables rapid and practical synthesis of functionalized nitrogen-based heterocycles in high yields under additive and metal-free, mild photochemical conditions.
Departamento de Química, Universidade Federal de São Carlos, São Carlos, 97105-900, SP, Brazil. mwpaixao@ufscar.br.
Gustavo Piva
GP
da Silva
Akbar
A
Ali
Rodrigo César
RC
da Silva
Hao
H
Jiang
Márcio W
MW
Paixão
D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis*; D008027:Light; D008956:Models, Chemical; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D012821:Silanes / Q000737:chemistry*
D005609:Free Radicals; D007211:Indoles; D012821:Silanes; C510691:tris(trimethylsilyl)silane