Effect of new berberine derivatives on colon cancer cells.
The natural alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy and bioavailability, several derivatives have been designed and synthesized and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, five compounds were identified to be able to heavily affect the proliferation of human HCT116 and SW613-B3 colon carcinoma cell lines. Remarkably, these active compounds exhibit high fluorescence emission property and ability to induce autophagy.
Istituto di Genetica Molecolare CNR, Pavia 27100, Italy Departamento de Ciencias de la Salud, Universidad Técnica Particular de Loja, Loja, Ecuador.
Luis Miguel
LM
Guamán Ortiz
Istituto di Genetica Molecolare CNR, Pavia 27100, Italy.
Anna Leta
AL
Croce
Istituto di Genetica Molecolare CNR, Pavia 27100, Italy Dipartimento di Biologia e Biotecnologie 'L. Spallanzani', Università degli Studi di Pavia, Pavia, Italy.
Francesca
F
Aredia
Istituto di Genetica Molecolare CNR, Pavia 27100, Italy.
Simone
S
Sapienza
Naxospharma srl, Novate Milanese, Italy.
Gaetano
G
Fiorillo
Naxospharma srl, Novate Milanese, Italy.
Tanjia Monir
TM
Syeda
Naxospharma srl, Novate Milanese, Italy.
Franco
F
Buzzetti
Naxospharma srl, Novate Milanese, Italy.
Paolo
P
Lombardi
Istituto di Genetica Molecolare CNR, Pavia 27100, Italy scovassi@igm.cnr.it.
Anna Ivana
AI
Scovassi
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis; D017209:Apoptosis / Q000187:drug effects*; D001599:Berberine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001599:Berberine
apoptosis; autophagy; berberine; colon cancer; fluorescence