Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity response.
Some ergostane triterpenoids from Taiwanofungus camphoratus have been shown to exhibit anti-inflammatory activity in vitro. However, the effect of ergostane triterpenoids on the immune response remains unknown. In this study, we elucidated that ergostane triterpenoids significantly decreased the cytokines and chemokine release by dendritic cells (DC) and that, in the case of zhankuic acid C (ZAC), the decrease was dose-dependent and inhibited DC maturation. ZAC inhibited the contact hypersensitivity response and infiltrative T cells in the ears of DNFB-stimulated mice. Thus, we demonstrate for the first time that ZAC exhibits an immunosuppressive effect on DC activation and the contact hypersensitivity response. It is suggested that ZAC can potentially be used for treating chronic inflammation and autoimmune diseases.
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan.
Ming-Kuem
MK
Lin
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan.
Meng-Shiou
MS
Lee
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan.
Wen-Te
WT
Chang
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan.
Hsing-Yu
HY
Chen
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan.
Jin-Fu
JF
Chen
Institute of Medical Technology, College of Life Science, National Chung Hsing University, Taichung, Taiwan.
Yi-Rong
YR
Li
Institute of Medical Technology, College of Life Science, National Chung Hsing University, Taichung, Taiwan. Electronic address: lincc@dragon.nchu.edu.tw.
Chi-Chen
CC
Lin
Department of Pharmacy, National Cheng Kung University, Tainan, Taiwan; Department of Pharmacy, Tajen University, Pingtung, Taiwan. Electronic address: tswu@mail.ncku.edu.tw.
Tian-Shung
TS
Wu
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007165:Immunosuppression Therapy; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D018925:Chemokines; D016207:Cytokines; D008070:Lipopolysaccharides; C098428:zhankuic acid C; D004875:Ergosterol
Contact hypersensitivity response; Dendritic cell; Immunosuppression; Taiwanofungus camphoratus; Zhankuic acid C