Metastasis of Gastric Signet-Ring Cell Carcinoma to the Urinary Bladder: A Case Report and Review of the Literature.
Although signet-ring cell (SRC) adenocarcinoma is commonly seen in the stomach, it is a very rarely seen histologic entity in the bladder. It is difficult to distinguish primary SRC adenocarcinoma of the bladder from bladder metastasis of SRC carcinoma of the stomach only based on histological findings. In such cases, clinical findings and immunohistochemical studies may be helpful. We present here a 48-year-old male patient presenting with hematuria and abdominal pain. Computerised tomography of the patient revealed a gastric mass, peritoneal involvement, and thickening of the bladder wall, and histopathological analysis revealed SRC adenocarcinoma in both of the endoscopic biopsies taken from the stomach and bladder. Immunohistochemical analyses confirmed the diagnosis of SRC adenocarcinoma of the bladder secondary to gastric cancer.
Department of Medical Oncology, Acibadem University School of Medicine, Buyukdere Cad, No. 40, Sariyer, 34453 Istanbul, Turkey.
Kerem
K
Okutur
Department of Medical Oncology, Yeditepe University School of Medicine, Devlet Yolu, Ankara Caddesi, No. 102-104, Kozyatagi, 34652 Istanbul, Turkey.
Orhan Onder
OO
Eren
Department of Medical Oncology, Acibadem University School of Medicine, Buyukdere Cad, No. 40, Sariyer, 34453 Istanbul, Turkey.
Gokhan
G
Demir