Are Osteopontin and Ki67 Expressions Different in Various Histologic Grades of Meningioma? An Iranian Experience.
BACKGROUND
Meningioma is among the most common slow growing central nervous neoplasms, which recurs locally despite the benign histologic features. The aim of this study was to evaluate osteopontin and ki67 expressions in different histologic grades of meningioma in a group of Iranian people.


METHODS
In this cross-sectional study, first, the paraffin blocks with the definite pathological diagnosis of meningioma in 70 patients were cut by microtome, in 4-5 micron sizes and stained for immunohistochemical markers of osteopontin and ki67. Then, all samples were evaluated for positive immunoreactivity and contributing factors.


RESULTS
Among 70 pateints studied, the mean for the Ki67 level was 8.6±12.3 and the mean for the osteopontinm IHC score was 45.2±77.9. There was a high correlation between markers, tumor recurrence and grade (P<0.001). In addition, there was a significant direct correlation between ki67 and osteopontin levels (P<0.001, r=0.760). In other words, as OPN and ki67 expressions increased, the chance of tumor recurrence increased.


CONCLUSIONS
ki67 and osteopontin expressions in patients with meningioma can be used as good prognostic markers for tumor recurrence and for distinguishing the grade of meningiomas.
Dept. of Pathology, Iran University of Medical Sciences, Tehran, Iran.
Forough
F
Hashemi
Dept. of Pathology, Iran University of Medical Sciences, Tehran, Iran.
Pegah
P
Babaheidarian
Dept. of Social Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Soheila
S
Dabiran
Ki67 Antigen; Meningioma; Osteopontin