Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.
BACKGROUND
The IL17 pathway plays an important role in the pathogenesis of psoriasis (PsO).


OBJECTIVE
To determine whether the variation at the IL17 pathway genes was linked to the risk for PsO or had an effect on disease severity and the risk for Psoriatic arthritis (PsA).


METHODS
Cross-sectional observational study of 580 psoriasis patients and 567 healthy controls who were genotyped for six single nucleotide polymorphisms (SNPs) in the IL17RA (rs4819554, rs879577), IL17A (rs7747909), IL17F (rs763780, rs2397084), and IL17E (rs79877597) genes.


RESULTS
We found significant higher frequencies of IL17RA rs4819554 G carriers among the patients (OR=1.33, 95%CI=1.05-1.69; p=0.017). The IL17RA rs4819554 G allele and IL17F rs2397084 TT genotype were significantly more frequent among Cw6 positive patients (p=0.037 and p=0.010, respectively). The IL17E rs79877597C allele was significantly more common among patients with severe forms of PsO (p=0.010; OR=2.42, 95%CI=1.23-4.76), and the CC genotype with the presence of arthritis (p=0.032; OR=1.50, 95%CI=1.04-2.18).


CONCLUSIONS
We identified the IL17RA rs4819554 SNP as a risk factor for PsO. The IL17E rs79877597 SNP was a modifier of the risk for PsO disease severity and PsA.
Department of Dermatology II, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain.
Ana
A
Batalla
Department of Molecular Genetics, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain; Department of Medicine, Universidad de Oviedo, Calle San Francisco, 1, 33003 Oviedo, Spain.
Eliecer
E
Coto
Department of Dermatology II, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain.
Leire
L
González-Lara
Department of Dermatology II, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain.
Daniel
D
González-Fernández
Department of Molecular Genetics, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain.
Juan
J
Gómez
Department of Molecular Genetics, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain.
Tamara F
TF
Aranguren
Department of Rheumatology, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain.
Rubén
R
Queiro
Department of Dermatology II, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain.
Jorge
J
Santos-Juanes
Department of Immunology, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain.
Carlos
C
López-Larrea
Department of Dermatology II, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain; Department of Medicine, Universidad de Oviedo, Calle San Francisco, 1, 33003 Oviedo, Spain. Electronic address: cotopablo@uniovi.es.
Pablo
P
Coto-Segura
D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D053722:Receptors, Interleukin-17 / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013030:Spain
C109985:IL17RA protein, human; C486701:IL25 protein, human; D020381:Interleukin-17; D053722:Receptors, Interleukin-17
Gene polymorphism; Genetic susceptibility; Genotypes; IL17 pathway genes; Psoriasis; Psoriatic arthritis