Influenza vaccine effectiveness among healthcare workers in comparison to hospitalized patients: A 2004-2009 case-test, negative-control, prospective study.
The objective of this study was to calculate Vaccine Effectiveness (VE) in healthcare workers (HCW) and to compare VE between patients and HCW. A case-control investigation based on the prospective study was conducted between 2004 and 2009 in a teaching hospital. All HCW with influenza-like illness (ILI) from participating units (n = 24) were included, and vaccination status was characterized by interview. A total of 150 HCW presented ILI; 130 (87%) were female, 27 (18%) were positive for influenza, and 42 (28%) were vaccinated. Adjusted VE was 89% (95% CI 39 to 98). Among patients, adjusted VE was 42% (95% CI -39 to 76). The difference of VE (VEhcw - VEpat) was 46.15% (95% CI 2.41 to 144). The VE ratio (VEhcw / VEpat) was 2.09 (95% CI -1.60 to 134.17). Influenza VE differed between HCW and patients when the flu season was taken into account. This finding confirms the major impact of host determinants on influenza VE.
a Service d'Hygiène; Epidémiologie et Prévention; Groupement hospitalier Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.|b Laboratoire d'Epidémiologie et Santé Publique; Université Claude Bernard Lyon 1; Université de Lyon ; Lyon , France.
P
P
Vanhems
b Laboratoire d'Epidémiologie et Santé Publique; Université Claude Bernard Lyon 1; Université de Lyon ; Lyon , France.
Y
Y
Baghdadi
c Service de Biostatistique; Groupement hospitalier Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.|d Equipe Biostatistique-Santé; Center National de la Recherche Scientifique-Unité Mixte de Recherche 5558; Université Claude Bernard Lyon 1; Université de Lyon ; Villeurbanne , France.
S
S
Roche
a Service d'Hygiène; Epidémiologie et Prévention; Groupement hospitalier Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.
T
T
Bénet
b Laboratoire d'Epidémiologie et Santé Publique; Université Claude Bernard Lyon 1; Université de Lyon ; Lyon , France.
C
C
Regis
e Centre de Biologie et Pathologie Est; Center National de référence des virus influenza région Sud; Groupement Hospitalier Est; Hospices Civils de Lyon ; Bron , France.|f Département de Virologie ; Université Lyon 1; Université de Lyon ; Bron , France.
B
B
Lina
g Service de médecine Préventive du Personnel; Groupement hospitalier Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.
O
O
Robert
a Service d'Hygiène; Epidémiologie et Prévention; Groupement hospitalier Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.
N
N
Voirin
c Service de Biostatistique; Groupement hospitalier Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.|d Equipe Biostatistique-Santé; Center National de la Recherche Scientifique-Unité Mixte de Recherche 5558; Université Claude Bernard Lyon 1; Université de Lyon ; Villeurbanne , France.
R
R
Ecochard
a Service d'Hygiène; Epidémiologie et Prévention; Groupement hospitalier Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.
S
S
Amour
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006282:Health Personnel; D006784:Hospitals, Teaching; D006801:Humans; D000071497:Immunogenicity, Vaccine / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014611:Vaccination / Q000706:statistics & numerical data
D007252:Influenza Vaccines
Seasonal influenza; healthcare workers; influenza vaccine effectiveness; vaccination