Immune memory responses to HBV vaccine 13-18 years after primary vaccination.
The aim of this study was to evaluate the immune memory response 13-18 years after an hepatitis B virus (HBV) vaccine by performing a specific in vitro stimulation experiment. Thirty healthy volunteers who had been inoculated 13-18 years ago with the HBV vaccine were collected from the physical examination center. Peripheral blood mononuclear cells were stimulated with 50 ng/mL recombinant HBsAg. An ELISA kit was used for the detection of antibodies that were produced by these cells in vitro. It was found that even 13-18 years after inoculation with the HBV vaccine, an anamnestic antibody response still existed, and was not correlated with the serum antibody levels (r = -0.177, P = 0.377). In conclusion, our data showed that the individuals after inoculation, including those with anti-HBs <10 IU/L as well as those individuals in whom the antibody was not detected, retained immune memory, which may be the main role of memory B cells.
Department of Infectious Diseases Ι, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China.
L
L
Hou
Department of Infectious Diseases Ι, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China.
W
W
Li
Department of Infectious Diseases ΙI, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China.
X
X
Wei
Department of Infectious Diseases ΙI, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China.
Y
Y
Zhou
Department of Infectious Diseases ΙI, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China.
Y
Y
Zhuo
Department of Infectious Diseases Ι, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China.
H
H
Wu
Department of Infectious Diseases Ι, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China.
B
B
Shen
D001402:B-Lymphocytes / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines