The effect of erythropoietin on serum uric acid levels during renal ischemia reperfusion injury in rats.
OBJECTIVE
The aim of this experimental study was to assess the effect of erythropoietin on a rat model, particularly under a renal ischemia reperfusion protocol. The beneficial or lack of effects of that molecule on the excreted renal product of serum uric acid were studied biochemically.


METHODS
Forty rats were used with a mean weight of 247.7 gr. Serum uric acid levels were measured measured at 60 min after reperfusion (Groups A and C) and at 120 min after reperfusion (groups B and D).


RESULTS
1) Erythropoietin administration non-significantly decreased the serum uric acid levels non-significantly by 0.02 mg/dL [-0.2415423 mg/dL-0.2015423 mg/dL] (p=0.8560), in accordance with the paired t-test (p=0.8438). Reperfusion time non-significantly increased the serum uric acid levels non-significantly by 0.17 mg/dL [-0.0444933 mg/dL-0.3844933 mg/dL] (p=0.1169), in accordance with the paired t-test (p=0.1648). 3) The interaction of erythropoietin administration and reperfusion time non-significantly increased the serum uric acid levels non-significantly by 0.1 mg/dL [-0.0295564 mg/dL-0.2295564 mg/dL] (p=0.1264).


CONCLUSIONS
Erythropoietin administration, reperfusion time and their interaction have no significant short-term alterations on serum uric acid levels. Conclusions cannot be extracted by non-significant p-values within 2 hours. Obviously, longer study times may permit safer results.
Department of Obstetrics and Gynecology, Mesologi County Hospital, Etoloakarnania, Greece.
Constantinos
C
Tsompos
Department of Obstetrics and Gynecology, Aretaieio Hospital, Athens University, Attiki, Greece.
Constantinos
C
Panoulis
Department of Surgery, Ippokrateio Hospital, Athens University, Attiki, Greece.
Konstantinos
K
Toutouzas
Department of Surgery, Ippokrateio Hospital, Athens University, Attiki, Greece.
George
G
Zografos
Elpen Pharmaceuticals S.a. Co. Inc., Pikermi, Attiki, Greece.
Apostolos
A
Papalois
Erythropoietin; ischemia; kidneys; reperfusion; uric acid