[A Case of Hereditary Medullary Thyroid Cancer (MEN2A/FMTC) Diagnosed at the Time of Recurrence].
We report a 42-year-old man with hereditary medullary thyroid cancer (multiple endocrine neoplasia, MEN2A/familial medullary thyroid carcinoma, FMTC), which was diagnosed at the time of tumor recurrence. He had a past history of a left thyroidectomy with neck dissection 7 years previously. A RET gene analysis revealed a point mutation (codon 618), and we diagnosed him as having hereditary medullary thyroid cancer. We resected the recurrent tumor in the right thyroid lobe together with performing a right lateral and central neck dissection. A RET gene analysis should be performed for patients with medullary thyroid cancer. When a RET gene mutation is present, a total thyroidectomy must be performed for the medullary thyroid cancer.
Keisuke
K
Enomoto
Kotaro
K
Shimizu
Masayuki
M
Hirose
Haruka
H
Miyabe
Natsue
N
Morizane
Yukinori
Y
Takenaka
Kohki
K
Shimazu
Hiroaki
H
Fushimi
Atsuhiko
A
Uno
D000328:Adult; D001483:Base Sequence; D018276:Carcinoma, Medullary / Q000151:congenital* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging; D018813:Multiple Endocrine Neoplasia Type 2a / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D009154:Mutation; D049268:Positron-Emission Tomography; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D012008:Recurrence; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed
D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human