S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever.
Familial Mediterranean fever (FMF) is an auto-inflammatory disease characterised by periodic inflammatory attacks. We investigated changes in monocyte-granulocyte derived S10012A and chitotriosidase in both the attack and silent period of FMF for better estimation of inflammation. Endogenous resolvin was determined for utility to restrict inflammation. This study included 29 FMF patients (15 M/14 F) and 30 healthy controls (15 M/15 F). Serum levels of highly sensitive C-reactive protein, serum amiloid A (SAA), S100A12, chitotriosidase, and resolvin D1 were measured. Age, sex, body mass indexes, and lipids were similar between patients and controls. Biomarkers including hs-CRP, SAA, S100A12, chitotriosidase, and resolvin D1 were higher in the attack period of FMF patients compared to controls (P < 0.001). When FMF patients in the silent period were compared with their attack period, hs-CRP, SAA, and chitotriosidase were found elevated in the attack period (P < 0.001, P < 0.001, and P = 0.02 respectively). Serum levels of SAA, S100A12, chitotriosidase, and resolvin D1 in the silent period of FMF patients were still found elevated compared to healthy controls, indicating subclinical inflammation (P < 0.001, P < 0.001, P = 0.009, and P < 0.001 respectively ). In subgroup analysis, patients with M694V homozygote and heterozygote mutations had higher S10012A and hs-CRP compared to other mutation carriers. Our findings indicate that chitotriosidase and S10012A are useful in diagnosis and detection of subclinical inflammation and/or assessment of disease activity in FMF patients. They could be more informative for inflammation in various disease states compared to hsCRP and SAA. Resolvin D1 is elevated in both the attack and silent periods of FMF. It may be helpful to restrict inflammation.
Izmir Tepecik Training and Research Hospital, Department of Rheumatology, Izmir, Turkey.
Ali
A
Taylan
Medical Park Hospital, Department of Internal Medicine, Division of Rheumatology, Samsun, Turkey.
Oguz
O
Gurler
Izmir Tepecik Training and Research Hospital, Department of Biochemistry, Izmir, Turkey.
Burak
B
Toprak
Dokuz Eylul University School of Medicine, Department of Biochemistry, Izmir, Turkey.
Ali Riza
AR
Sisman
Izmir Tepecik Training and Research Hospital, Department of Biochemistry, Izmir, Turkey.
Hulya
H
Yalcin
Izmir Tepecik Training and Research Hospital, Department of Biochemistry, Izmir, Turkey.
Ayfer
A
Colak
Dokuz Eylul University School of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir, Turkey.
Ismail
I
Sari
D000328:Adult; D015415:Biomarkers; D004281:Docosahexaenoic Acids / Q000097:blood*; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000175:diagnosis*; D005240:Feasibility Studies; D005260:Female; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D000067616:S100A12 Protein / Q000097:blood*; D012680:Sensitivity and Specificity
D015415:Biomarkers; D000067616:S100A12 Protein; C090441:S100A12 protein, human; C518399:resolvin D1; D004281:Docosahexaenoic Acids; D006596:Hexosaminidases; C086400:chitotriosidase
Chitotriosidase; Familial Mediterranean Fever; Resolvin D1; S100A12; Serum Amiloid A