Effectiveness of a Chlorhexidine Digluconate 0.12% and Cetylpyridinium Chloride 0.05% Solution in eliminating Candida albicans Colonizing Dentures: A Randomized Clinical in vivo Study.
Effective denture hygiene is important for patients suffering from denture stomatitis (DS). This study aimed to evaluate the efficacy of a solution containing 0.12% chlorhexidine (CHX) digluconate and 0.05% cetylpyridinium chloride (CPC) in eliminating Candida albicans colonizing dentures.



Forty denture wearers (11 men, 29 women; age range 40 to 80 years) with clinical evidence of DS were randomly divided into two groups, one test and one control. The dentures of the test group were treated by immersion in a solution of 0.12% CHX and 0.05% CPC while those of the control group were immersed in distilled water. Swabs were collected from the fitting surfaces of the upper dentures prior and post cleaner use and examined mycologically.



Reduction in the number of colony-forming units (CFU) of Candida albicans after immersion of the dentures in a solution of 0.12% CHX and 0.05% CPC was significantly greater than that of the control group.



A solution of 0.12% CHX and 0.05% CPC tested as a product of disinfection of the acrylic dentures showed significant results after immersion of 8 night hours for 4 days.
Assistant Professor, Department of Oral Pathology and Diagnosis, School of Dentistry, Lebanese University, Beirut, Lebanon, e-mail: aoungeorges@yahoo.com.
Georges
G
Aoun
Department of Oral Pathology and Diagnosis, School of Dentistry, Lebanese University, Beirut, Lebanon.
Antoine
A
Cassia
Department of Oral and Maxillofacial Surgery, School of Dentistry, Lebanese University, Beirut, Lebanon.
Antoine
A
Berberi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D002176:Candida albicans / Q000187:drug effects*; D002594:Cetylpyridinium / Q000008:administration & dosage*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003820:Denture Cleansers / Q000627:therapeutic use; D003778:Dentures / Q000382:microbiology*; D004203:Disinfection; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013282:Stomatitis, Denture / Q000382:microbiology / Q000628:therapy
D000891:Anti-Infective Agents, Local; D003820:Denture Cleansers; D002594:Cetylpyridinium; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
Candida albicans; Cetylpyridinium chloride; Chlor-hexidine digluconate; Denture stomatitis.