The Influence of Bariatric Surgery on Serum Bile Acids in Humans and Potential Metabolic and Hormonal Implications: a Systematic Review.
Recent research suggests a mechanistic role for bile acids (BA) in the metabolic improvement following bariatric surgery. It is believed that the hormonal and metabolic effects associated with changes in systemic BAs may be related to the farnesoid X receptor (FXR) and a G-protein coupled receptor (TGR5). This systematic review examines changes in systemic BAs following bariatric procedures. Studies were included if they reported the measurement of systemic BAs in humans at at least one time point after bariatric surgery. Eleven papers were identified that met the inclusion criteria. Seven studies reported the effect of Roux-en-Y gastric bypass (RYGB) on fasting BAs. The majority (6/7) reported that fasting BAs increased after RYGB. Data regarding fasting BAs after vertical sleeve gastrectomy (VSG) and laparoscopic gastric banding (LAGB) are inconsistent. Data regarding post-prandial BA changes after RYGB, VSG, and LAGB are also inconsistent. More research is needed to investigate the connection between BAs and the metabolic improvement seen after bariatric surgery.
Department of Food Science and Nutrition, University of Minnesota-Twin Cities, 1334 Eckles Avenue, Saint Paul, MN, 55108, USA. cole0463@umn.edu.
Abigail J
AJ
Cole
Department of Food Science and Nutrition, University of Minnesota-Twin Cities, 1334 Eckles Avenue, Saint Paul, MN, 55108, USA. teige027@umn.edu.
Levi M
LM
Teigen
Medical School, Department of Surgery, University of Minnesota-Twin Cities, 420 Delaware Street SE, Minneapolis, MN, 55404, USA. jahan023@umn.edu.
Cyrus
C
Jahansouz
Department of Food Science and Nutrition, University of Minnesota-Twin Cities, 1334 Eckles Avenue, Saint Paul, MN, 55108, USA. cearthma@umn.edu.
Carrie P
CP
Earthman
Department of Medicine, Division of Endocrinology, University of Minnesota-Twin Cities, 516 Delaware St. SE, Minneapolis, MN, 55455, USA. sible004@umn.edu.
Shalamar D
SD
Sibley
D001647:Bile Acids and Salts / Q000378:metabolism*; D015992:Body Mass Index; D005215:Fasting / Q000097:blood; D005743:Gastrectomy; D015390:Gastric Bypass; D006801:Humans; D009767:Obesity, Morbid / Q000378:metabolism / Q000601:surgery*; D011184:Postoperative Period; D019518:Postprandial Period; D015431:Weight Loss
D001647:Bile Acids and Salts
Bariatric surgery; Bile acids; FXR; Gastric bypass; Metabolism; Obesity; RYGB; TGR5; Vertical sleeve gastrectomy