Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia.
We determined the alleles of ten single nucleotide poly-morphisms (SNPs) in the APOA5/A4/C3/A1 gene cluster and in APOB in Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, and explored the correlation between these SNPs and dyslipidemia through a case-control study design with 250 pa-tients and 250 normal controls. All SNPs except for APOA5 rs2072560 conformed to Hardy-Weinberg equilibrium (all P > 0.05). APOA5 rs651821, APOA4 rs5104, APOC3 rs734104, and APOC3 rs5128 geno-type and allele frequencies were significantly different between groups (all P < 0.01). For rs651821, the risks of dyslipidemia for the CC or CC+CT genotypes were 9.917 or 1.859 times that of TT, and the risk of the C vs T allele was 2.027. For rs5104, the AG, GG, or AG+GG risks were 1.797, 1.861, and 1.809 times AA, and the G vs A risk was 1.427. For rs734104, the CT, CC, or CC+CT risks were 1.851, 2.570, and 1.958 times TT, and the C vs T risk was 1.610. For rs5128, the GC or CC+GC risks were 1.738 or 1.749 times GG, and the C vs G risk was 1.477. Compared with the wild-type haplotype TATG, the risks of dyslipidemia with CGCC, TGCC, or CATG haplotypes (odds ratios = 2.434, 1.503, and 2.740, respectively) were significantly higher. Our results suggested that these four SNPs were significantly associated with dyslipidemia in Xinjiang Shihezi Han Chinese, and might serve as risk factors for dyslipidemia. Individuals carrying the CGCC, TGCC, or CATG haplotypes were prone to dyslipidemia.
Department of Neurology, The First Affiliated Hospital, Medicine College, Shihezi University, Shihezi City, Xinjiang, China.
H J
HJ
Ou
Department of Gerontology, The First Affiliated Hospital, Medicine College, Shihezi University, Shihezi City, Xinjiang, China.
G
G
Huang
Department of Biochemical Teaching and Research, Medicine College, Shihezi University, Shihezi City, Xinjiang, China.
W
W
Liu
Department of Gerontology, The First Affiliated Hospital, Medicine College, Shihezi University, Shihezi City, Xinjiang, China.
X L
XL
Ma
Department of Clinical Laboratory, The First Affiliated Hospital, Medicine College, Shihezi University, Xinjiang, Shihezi City, Xinjiang, China.
Y
Y
Wei
Department of Medical Laboratory, The First Affiliated Hospital, Medicine College, Shihezi University, Shihezi City, Xinjiang, China.
T
T
Zhou
Department of Biochemical Teaching and Research, Medicine College, Shihezi University, Shihezi City, Xinjiang, China.
Z M
ZM
Pan
D000483:Alleles; D053305:Apolipoprotein C-III / Q000235:genetics*; D001054:Apolipoproteins A / Q000235:genetics*; D001055:Apolipoproteins B / Q000235:genetics*; D016022:Case-Control Studies; D050171:Dyslipidemias / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D053305:Apolipoprotein C-III; D001054:Apolipoproteins A; D001055:Apolipoproteins B