Understanding the effects of mature adipocytes and endothelial cells on fatty acid metabolism and vascular tone in physiological fatty tissue for vascularized adipose tissue engineering.
Engineering of large vascularized adipose tissue constructs is still a challenge for the treatment of extensive high-graded burns or the replacement of tissue after tumor removal. Communication between mature adipocytes and endothelial cells is important for homeostasis and the maintenance of adipose tissue mass but, to date, is mainly neglected in tissue engineering strategies. Thus, new co-culture strategies are needed to integrate adipocytes and endothelial cells successfully into a functional construct. This review focuses on the cross-talk of mature adipocytes and endothelial cells and considers their influence on fatty acid metabolism and vascular tone. In addition, the properties and challenges with regard to these two cell types for vascularized tissue engineering are highlighted.
Institute of Interfacial Process Engineering and Plasma Technology, University of Stuttgart, Nobelstraße 12, 70569, Stuttgart, Germany.
Birgit
B
Huber
Process Analysis & Technology (PA&T), Reutlingen University, Alteburgstraße 150, 72762, Reutlingen, Germany.
Ann-Cathrin
AC
Volz
Process Analysis & Technology (PA&T), Reutlingen University, Alteburgstraße 150, 72762, Reutlingen, Germany. petra.kluger@igb.fraunhofer.de.|Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Nobelstraße 12, 70569, Stuttgart, Germany. petra.kluger@igb.fraunhofer.de.
Petra J
PJ
Kluger
D017667:Adipocytes / Q000166:cytology*; D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D042783:Endothelial Cells / Q000166:cytology*; D006801:Humans; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering
Co-culture; Cross-talk; Endothelial cells; Mature adipocytes; Vascularized fatty tissue engineering