Genetic polymorphism of pharmacogenomic VIP variants in the Deng people from the Himalayas in Southeast Tibet.
Little is known about polymorphic distribution of pharmacogenes among ethnicities, including the Deng people. In this study, we recruited 100 unrelated, healthy Deng people and genotyped them with respect to 76 different single-nucleotide polymorphisms by the PharmGKB database. Our results first indicated that the polymorphic distribution of pharmacogenes of the Deng people is most similar to CHD, suggesting that Deng people have a closest genetic relationship with CHD. Our data will enrich the database of pharmacogenomics and provide a theoretical basis for safer drug administration and individualized treatment plans, promoting the development of personalized medicine.
a Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University , Xianyang , Shaanxi , China .
Xugang
X
Shi
Li
L
Wang
Shuli
S
Du
Huijuan
H
Wang
Tian
T
Feng
Tianbo
T
Jin
Longli
L
Kang
D000328:Adult; D044466:Asian People / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D018609:Tibet; D014660:Vasoactive Intestinal Peptide / Q000235:genetics*
D014660:Vasoactive Intestinal Peptide
Genetic polymorphisms; VIP variant; pharmacogenomics; the Deng people