Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity?
Bioregulatory systems medicine (BrSM) is a paradigm that aims to advance current medical practices. The basic scientific and clinical tenets of this approach embrace an interconnected picture of human health, supported largely by recent advances in systems biology and genomics, and focus on the implications of multi-scale interconnectivity for improving therapeutic approaches to disease. This article introduces the formal incorporation of these scientific and clinical elements into a cohesive theoretical model of the BrSM approach. The authors review this integrated body of knowledge and discuss how the emergent conceptual model offers the medical field a new avenue for extending the armamentarium of current treatment and healthcare, with the ultimate goal of improving population health.
Concept Systems, Inc. Ithaca, NY, USA ; Department of Sociology, Cornell University Ithaca, NY, USA.
Alyssa W
AW
Goldman
Biologische Heilmittel Heel GmbH Baden-Baden, Germany.
Yvonne
Y
Burmeister
Biologische Heilmittel Heel GmbH Baden-Baden, Germany.
Konstantin
K
Cesnulevicius
Transcend Research Laboratory, Massachusetts General Hospital Boston, MA, USA.
Martha
M
Herbert
Concept Systems, Inc. Ithaca, NY, USA.
Mary
M
Kane
International Academy of Bioregulatory Medicine Baden-Baden, Germany.
David
D
Lescheid
Division of Genomic Medicine, George Washington University Medical Center Washington, DC, USA.
Timothy
T
McCaffrey
Biologische Heilmittel Heel GmbH Baden-Baden, Germany.
Myron
M
Schultz
Biologische Heilmittel Heel GmbH Baden-Baden, Germany.
Bernd
B
Seilheimer
Biologische Heilmittel Heel GmbH Baden-Baden, Germany.
Alta
A
Smit
St. Laurent Institute Vancouver, WA, USA.
Georges
G
St Laurent
Center for Integrative Medicine, University of Maryland School of Medicine Baltimore, MD, USA.
Brian
B
Berman
autoregulation; bioregulatory systems medicine; genomics; inflammation; systems biology; systems medicine