Human neutrophil peptide-1 decreases during ageing in selected Mexican population.
Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has not been described. In the present study, we addressed the question whether antimicrobial activity in polymorphonuclear cells from elderly individuals was altered in comparison with young adults. We compared phagocytosis index, bacterial killing efficiency, myeloperoxidase activity and cathelicidin expression. Results showed that there were no statistical differences among groups. However, human neutrophil peptide-1 (HNP-1) was decreased in the elderly individuals group. Results suggest that the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases.
Medical Research Unit of Zacatecas, Mexican Institute of Social Security, UIMZ-IMSS, Interior de la alameda # 45 col centro, Zacatecas, Mexico. rondo_vm@yahoo.com.
Bruno
B
Rivas-Santiago
Medical Research Unit of Zacatecas, Mexican Institute of Social Security, UIMZ-IMSS, Interior de la alameda # 45 col centro, Zacatecas, Mexico.
Julio E
JE
Castañeda-Delgado
Medical Research Unit of Zacatecas, Mexican Institute of Social Security, UIMZ-IMSS, Interior de la alameda # 45 col centro, Zacatecas, Mexico.
Jeny
J
de Haro-Acosta
Medical Research Unit of Zacatecas, Mexican Institute of Social Security, UIMZ-IMSS, Interior de la alameda # 45 col centro, Zacatecas, Mexico.
Flor
F
Torres-Juarez
Medical Research Unit of Zacatecas, Mexican Institute of Social Security, UIMZ-IMSS, Interior de la alameda # 45 col centro, Zacatecas, Mexico.
Isabel
I
Frausto-Lujan
Medical Research Unit of Zacatecas, Mexican Institute of Social Security, UIMZ-IMSS, Interior de la alameda # 45 col centro, Zacatecas, Mexico.
Paulina
P
Marin-Luevano
Catedras-CONACyT, National Council of Science and Technology (CONACyT), Mexico City, Mexico.|Department of Immunology, Faculty of Medicine, Autonomous University of San Luis Potosí, San Luis Potosi, Mexico.
Roberto
R
González-Amaro
Catedras-CONACyT, National Council of Science and Technology (CONACyT), Mexico City, Mexico.
Jose A
JA
Enciso-Moreno
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007113:Immunity, Innate; D007375:Interleukin-1 / Q000235:genetics / Q000378:metabolism; D042541:Intracellular Space; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*; D009195:Peroxidase / Q000235:genetics / Q000378:metabolism; D010587:Phagocytosis; D023084:alpha-Defensins / Q000235:genetics / Q000378:metabolism*
C508587:IL37 protein, human; D007375:Interleukin-1; D023084:alpha-Defensins; C406413:human neutrophil peptide 1; D009195:Peroxidase
Ageing; Antimicrobial peptides; Elderly; HNP-1; Immunosenescence; LL-37