An Insidious Danger in Children With Familial Mediterranean Fever: Colchicine Intoxication.
Colchicine is an anti-inflammatory drug, which has been used for the treatment of familial Mediterranean fever for several decades with narrow therapeutic-toxicity window. Colchicine poisoning is rare but frequently a life-threatening emergency condition in pediatric practice. It may occur by excessive ingestion of colchicine tablets accidentally or intentionally. Herein, we report a suicide attempt with colchicine in a 12-year-old girl who had been followed up with the diagnosis of familial Mediterranean fever. She was admitted to our emergency department with gastrointestinal complaints and subsequently died because of the rapidly deteriorating metabolic and hemodynamic conditions.
From the Department of *Pediatrics, †Divisions of Pediatric Cardiology and ‡Pediatric Intensive Care, Ankara University School of Medicine, Ankara, Turkey.
Göksel
G
Vatansever
Cem
C
Karadeniz
Tanl
T
Kendirli
D000138:Acidosis / Q000139:chemically induced; D002648:Child; D003078:Colchicine / Q000008:administration & dosage / Q000506:poisoning*; D010505:Familial Mediterranean Fever / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D006074:Gout Suppressants / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D013406:Suicide, Attempted
D006074:Gout Suppressants; D003078:Colchicine