Four new triterpenes and triterpene glycosides from the leaves of Ilex latifolia and their inhibitory activity on triglyceride accumulation.
Two new triterpenes (1 and 2) and two new triterpene glycosides (3 and 4), along with six known triterpenes (5-10) were isolated from the leaves of Ilex latifolia. The structures of new compounds were elucidated on the basis of NMR, HR-MS, and X-ray diffraction analysis. Compounds 4 and 5 showed potent inhibitory activity on oleic acid/palmitic acid induced triglyceride accumulation on HepG2 cells.
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; College of Pharmacy, Wannan Medical College, Wuhu 241000, People's Republic of China.
Cun-Qin
CQ
Wang
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
Man-Mei
MM
Li
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
Wei
W
Zhang
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: cpuwanglei@126.com.
Lei
L
Wang
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
Chun-Lin
CL
Fan
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
Rui-Bing
RB
Feng
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
Xiao-Qi
XQ
Zhang
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: chyewc@gmail.com.
Wen-Cai
WC
Ye
D006027:Glycosides / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D019301:Oleic Acid; D019308:Palmitic Acid; D018515:Plant Leaves / Q000737:chemistry; D014280:Triglycerides / Q000378:metabolism*; D014315:Triterpenes / Q000737:chemistry*
D006027:Glycosides; D014280:Triglycerides; D014315:Triterpenes; D019301:Oleic Acid; D019308:Palmitic Acid
Ilex latifolia; Triterpene; Triterpene glycoside