Interaction between Flavivirus and Cytoskeleton during Virus Replication.
Flaviviruses are potentially human pathogens that cause major epidemics worldwide. Flavivirus interacts with host cell factors to form a favourable virus replication site. Cell cytoskeletons have been observed to have close contact with flaviviruses, which expands the understanding of cytoskeleton functions during virus replication, although many detailed mechanisms are still unclear. The interactions between the virus and host cytoskeletons such as actin filaments, microtubules, and intermediate filaments have provided insight into molecular alterations during the virus infection, such as viral entry, in-cell transport, scaffold assembly, and egress. This review article focuses on the utilization of cytoskeleton by Flavivirus and the respective functions during virus replication.
Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Kar Yue
KY
Foo
Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Hui-Yee
HY
Chee
D001693:Biological Transport, Active; D003599:Cytoskeleton / Q000378:metabolism*; D005416:Flavivirus / Q000502:physiology*; D018177:Flavivirus Infections / Q000378:metabolism*; D006801:Humans; D053586:Virus Internalization; D057074:Virus Release; D014779:Virus Replication / Q000502:physiology*