Beneficial Effects of Coenzyme Q10 Supplementation on Lipid Profile and Intereukin-6 and Intercellular Adhesion Molecule-1 Reduction, Preliminary Results of a Double-blind Trial in Acute Myocardial Infarction.
BACKGROUND
The present investigation was aimed to improve the inflammatory factors and lipoproteins concentration in patients with myocardial infarction (MI) by supplementation with coenzyme Q10 (CoQ10).


METHODS
In a double-blind, placebo-controlled study, we measured serum concentrations of one soluble cell adhesion molecules (intercellular adhesion molecule-1 [ICAM-1]), serum concentration of intereukin-6 (IL-6) and lipid profiles (high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], total cholesterol and triglyceride [TG]) in CoQ10 supplementation group (n = 26) compared with placebo group (n = 26) in hyperlipidemic patients with MI. Fifty-two patients were randomized to receive 200 mg/day of CoQ10 or placebo for 12 weeks.


RESULTS
There were no significant differences for serum LDL-C, total cholesterol, and TG between two mentioned groups after the intervention. A significant enhancement in serum HDL-C level was observed between groups after the intervention (55.46 ± 6.87 and 44.07 ± 6.99 mg/dl in CoQ10 and placebo groups, respectively P < 0.001). Concentrations of ICAM-1 (415.03 ± 96.89 and 453.38 ± 0.7 ng/dl CoQ10 and placebo groups, respectively, P = 0.001) and IL-6 (11 ± 9.57 and 12.55 ± 8.76 pg/ml CoQ10 and placebo groups, respectively P = 0.001) in serum were significantly decreased in CoQ10 group.


CONCLUSIONS
Supplementation with CoQ10 in hyperlipidemic patients with MI that have statin therapy has beneficial effects on their aspects of health.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Mona
M
Mohseni
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Mohammadreza
M
Vafa
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Mitra
M
Zarrati
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Farzad
F
Shidfar
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran ; Department of Internal Medicine (Cardiology Division), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Seyed Javad
SJ
Hajimiresmail
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Abbas
A
Rahimi Forushani
Coenzyme Q10; intercellular adhesion molecule-1; intereukin-6; lipoprotein; myocardial Infarction