Induction of Colon Cancer in Mice with 1,2-Dimethylhydrazine.
In this protocol, colon cancer is induced in mice through a series of injections with 1,2-dimethylhydrazine. Mice will develop primarily colon tumors starting at about 3 mo after the first injection. Tumors in the lung, uterus, and small intestine may also be seen, as well as lymphomas.
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.
Kay E
KE
Gurley
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.
Russell D
RD
Moser
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.
Christopher J
CJ
Kemp
D019813:1,2-Dimethylhydrazine / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007279:Injections, Subcutaneous; D051379:Mice; D013997:Time Factors
D019813:1,2-Dimethylhydrazine