Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early-stage Parkinson's disease.
The identification of cell-free circulating mitochondrial DNA (ccf-mtDNA) in early-stage Alzheimer's disease (AD) raised the possibility that the same neurodegenerative effect could be observed in Parkinson's disease (PD). Here, and for the first time, we investigated the role of ccf-mtDNA in PD, identifying a significant reduction of ccf-mtDNA in PD patient cerebrospinal fluid (CSF) when compared to controls. Our data demonstrates that CSF ccf-mtDNA is not only a powerful biomarker for PD, but, given that the effect is also observed in AD, is likely a biomarker for neurodegeneration.
Mitochondrial Research Group, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.
Angela
A
Pyle
Mitochondrial Research Group, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.
Rebecca
R
Brennan
Mitochondrial Research Group, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.
Marzena
M
Kurzawa-Akanbi
Insitutute of Neuroscience, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.
Alison
A
Yarnall
Insitutute of Neuroscience, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.
Anais
A
Thouin
Institute for Neuropathology, University of Goettingen, Goettingen, Germany.
Brit
B
Mollenhauer
Insitutute of Neuroscience, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.
David
D
Burn
Mitochondrial Research Group, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.
Patrick F
PF
Chinnery
Mitochondrial Research Group, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.
Gavin
G
Hudson
D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D004272:DNA, Mitochondrial / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D004272:DNA, Mitochondrial