Lack of association between an insertion/deletion polymorphism in IL1A and risk of colorectal cancer.
Previous study has shown that miR-122, miR-378, and their target gene IL1A may play crucial roles in the tumorigenesis of colorectal cancer (CRC). An insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of IL1A has been identified as a contributing factor to the risk of developing several cancers. The aim of this study was to evaluate the effect of IL1A rs3783553 on CRC risk. CRC patients (N = 339) and healthy control subjects (N = 313) were enrolled and genomic DNA was extracted from peripheral venous blood. The IL1A rs3783553 polymorphism was genotyped using a polymerase chain reaction assay. No significant differences in IL1A rs3783553 genotype frequencies were found between CRC cases and controls in an analysis of the overall data [ins/ del vs del/del: adjusted odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.69-1.34; ins/ins vs del/del: adjusted OR = 0.71, 95%CI = 0.43- 1.16; ins vs del: adjusted OR = 0.86, 95%CI = 0.69-1.09], nor when data were stratified according to clinical parameters. These findings indicate that the IL1A rs3783553 polymorphism does not constitute a risk factor for the development of CRC.
Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
H
H
Yan
Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, Yunnan, China.
R
R
Sun
Department of Forensic Pathology, College of Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
X
X
Pan
Secondary Department of General Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University.
Z
Z
Li
Department of Otolaryngology, Third Affiliated Hospital of Henan University of Science and Technology (Luo Yang East Hospital), Luoyang, Henan, China.
X
X
Guo
Laboratory of Molecular and Translational Medicine, West China Institute of Women's and Children's Health, cdchglb@gmail.com.
L
L
Gao
D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D054643:INDEL Mutation; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
C508584:IL1A protein, human; D053582:Interleukin-1alpha; C531907:MIRN122 microRNA, human; C526012:MIRN378 microRNA, human; D035683:MicroRNAs