Serum total oxidant/anti-oxidant status, ischemia-modified albumin and oxidized-low density lipoprotein levels in patients with vitamin D deficiency.
OBJECTIVE
Oxidative damage may be responsible for the pathogenesis and complications of many diseases. Vitamin D deficiency has been suggested as a potential mediator of various extra-skeletal pathologies. However, there are limited data on anti-oxidant properties of vitamin D.


METHODS
Forty-one subjects with vitamin D deficiency and 30 healthy controls were enrolled into the study. The levels of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), oxidized-low density lipoprotein (ox-LDL), high-sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured in both groups. The measurements were repeated in 17 patients after the replacement of vitamin D.


RESULTS
Serum IMA and TOS levels were significantly higher (p < 0.001 and p = 0.035, respectively), while TAS levels were significantly lower in patients, compared to controls (p < 0.001). Additionally, fibrinogen was significantly higher in patients than controls (p = 0.003), while ox-LDL and hs-CRP levels were similar between two groups. After the replacement of vitamin D, TAS level significantly increased (p = 0.037), and TOS and fibrinogen levels significantly decreased (p = 0.043 and p = 0.010, respectively). Vitamin D levels were negatively correlated with IMA and fibrinogen levels (r = -0.500, p < 0.001 and r = -0.391, p = 0.002, respectively), although positively correlated with TAS levels (r = 0.430, p < 0.001). No correlation was found between vitamin D levels, and the TOS, ox-LDL and hs-CRP levels.


CONCLUSIONS
In this study, while serum IMA, TOS and fibrinogen levels were increased, TAS levels were seen to be decreased in patients with vitamin D deficiency. These results suggest that oxidative/anti-oxidative balance shifts in favours of oxidative status in vitamin D deficiency.
Department of Endocrinology and Metabolism, Konya Education and Research Hospital, Konya, TR.
Husniye
H
Baser
Department of Biochemistry, Konya Education and Research Hospital, Konya, TR.
Ummugulsum
U
Can
Department of Internal Medicine, Konya Education and Research Hospital, Konya, TR.
Salih
S
Baser
Department of Internal Medicine, Konya Education and Research Hospital, Konya, TR.
Bahauddin Taha
BT
Hidayetoglu
Department of Internal Medicine, Konya Education and Research Hospital, Konya, TR.
Uysaler
U
Aslan
Department of Internal Medicine, Konya Education and Research Hospital, Konya, TR.
Ilker
I
Buyuktorun
Department of Biochemistry, Faculty of Medicine, Necmettin Erbakan University, Konya, TR.
Fatma Humeyra
FH
Yerlikaya
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D016877:Oxidants / Q000097:blood*; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D014808:Vitamin D Deficiency / Q000097:blood*
D015415:Biomarkers; D008077:Lipoproteins, LDL; D016877:Oxidants; D012709:Serum Albumin; C561522:ischemia-modified albumin; C099252:oxidized low density lipoprotein; D005340:Fibrinogen; D002097:C-Reactive Protein; D000075462:Serum Albumin, Human