Dermal IL-17-producing γδ T cells establish long-lived memory in the skin.
Conventional αβ T cells have the ability to form a long-lasting resident memory T-cell (TRM ) population in nonlymphoid tissues after encountering foreign antigen. Conversely, the concept of 'innate memory', where the ability of nonadaptive branches of the immune system to deliver a rapid, strengthened immune response upon reinfection or rechallenge, is just emerging. Using the αβ T-cell-independent Aldara psoriasis mouse model in combination with genetic fate-mapping and reporter systems, we identified a subset of γδ T cells in mice that is capable of establishing a long-lived memory population in the skin. IL-17A/F-producing Vγ4(+) Vδ4(+) T cells populate and persist in the dermis for long periods of time after initial stimulation with Aldara. Experienced Vγ4(+) Vδ4(+) cells show enhanced effector functions and mediate an exacerbated secondary inflammatory response. In addition to identifying a unique feature of γδ T cells during inflammation, our results have direct relevance to the human disease as this quasi-innate memory provides a mechanistic insight into relapses and chronification of psoriasis.
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Tom
T
Hartwig
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.|Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Stanislav
S
Pantelyushin
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Andrew L
AL
Croxford
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Paulina
P
Kulig
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Burkhard
B
Becher
D000818:Animals; D004195:Disease Models, Animal; D005434:Flow Cytometry; D007156:Immunologic Memory / Q000276:immunology*; D020381:Interleukin-17 / Q000096:biosynthesis / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D011565:Psoriasis / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D012867:Skin / Q000166:cytology / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D020381:Interleukin-17; D016692:Receptors, Antigen, T-Cell, gamma-delta
Aldara; IL-17; Immunological memory; Skin; γδ T cells