Clinical and laboratory characteristics of patients with thyroid diseases with and without alanine aminotransferase levels above the upper tertile - Cross-sectional analytical study.
Objective Thyroid disease affects 6.6% of the general population. The liver is fundamental in metabolizing thyroid hormones, and hepatocytes are often affected in thyroid disease. We aimed to compare clinical and laboratory parameters among thyroid disease patients with alanine aminotransferase (ALT) levels above vs. below the upper tertile. Subjects and methods A retrospective cross-sectional analytical study was conducted in the endocrinology clinic at Polydoro Ernani de São Thiago University Hospital. Patients with thyroid disease between August 2012 and January 2014 were included in the study. Clinical and laboratory parameters were collected from medical records. Results One hundred patients were included, of which 14.0% were male, with a mean age of 49.1 ± 14.4 years. ALT levels ranged from 9 to 90 U/L, and the ALT upper tertile was defined as 0,64 times the upper normal limit (xUNL). Patients with ALT levels above the upper tertile exhibited a higher proportion of systemic arterial hypertension (SAH), a higher mean abdominal circumference and a higher frequency of elevated TSH levels than did patients with ALT levels below the upper tertile. In multivariate analysis, ALT ≥ 0.64 (xUNL) was independently associated with abdominal circumference (odds ratio [OR] = 0.087, 95% confidence interval [CI] 0012-0167, P = 0.022). ALT (xUNL) correlated positively with total cholesterol (r = 0.213, P = 0.042). Conclusions In patients with thyroid diseases, it was observed that those with ALT above the upper tertile are associated with abdominal circumference and ALT levels correlate with total cholesterol.
Divisão de Gastroenterologia, Departamento de Medicina Interna, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Nathanael de Oliveira E
Nde O
Silva
UFSC, Florianópolis, SC, Brazil.
Marcelo Fernando
MF
Ronsoni
UFSC, Florianópolis, SC, Brazil.
Bruno da Silveira
Bda S
Colombo
UFSC, Florianópolis, SC, Brazil.
Carina Gabriela
CG
Corrêa
Divisão de Gastroenterologia, Departamento de Medicina Interna, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Simone Aiko
SA
Hatanaka
UFSC, Florianópolis, SC, Brazil.
Maria Heloisa Büsi da Silva
MH
Canalli
Divisão de Gastroenterologia, Departamento de Medicina Interna, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Leonardo de Lucca
Lde L
Schiavon
Divisão de Gastroenterologia, Departamento de Medicina Interna, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Janaína Luz
JL
Narciso-Schiavon
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008107:Liver Diseases / Q000097:blood; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors; D013959:Thyroid Diseases / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D055105:Waist Circumference
D013972:Thyrotropin; D002784:Cholesterol; D000410:Alanine Transaminase