Non-exercise physical activity attenuates motor symptoms in Parkinson disease independent from nigrostriatal degeneration.
OBJECTIVE
To investigate the relationship between time spent in non-exercise and exercise physical activity and severity of motor functions in Parkinson disease (PD).


BACKGROUND
Increasing motor impairments of PD incline many patients to a sedentary lifestyle. We investigated the relationship between duration of both non-exercise and exercise physical activity over a 4-week period using the Community Health Activities Model Program for Seniors (CHAMPS) questionnaire and severity of clinical motor symptoms in PD. We accounted for the magnitude of nigrostriatal degeneration.


METHODS
Cross-sectional study. PD subjects, n = 48 (40 M); 69.4 ± 7.4 (56-84) years old; 8.4 ± 4.2 (2.5-20) years motor disease duration, mean UPDRS motor score 27.5 ± 10.3 (7-53) and mean MMSE score 28.4 ± 1.9 (22-30) underwent [(11)C]dihydrotetrabenazine (DTBZ) PET imaging to assess nigrostriatal denervation and completed the CHAMPS questionnaire and clinical assessment.


RESULTS
Bivariate correlations showed an inverse relationship between motor UPDRS severity scores and duration of non-exercise physical activity (R = -0.37, P = 0.0099) but not with duration of exercise physical activity (R = -0.05, P = 0.76) over 4 weeks. Multiple regression analysis using UPDRS motor score as outcome variable demonstrated a significant regressor effect for duration of non-exercise physical activity (F = 6.15, P = 0.017) while accounting for effects of nigrostriatal degeneration (F = 4.93, P = 0.032), levodopa-equivalent dose (LED; F = 1.07, P = 0.31), age (F = 4.37, P = 0.043) and duration of disease (F = 1.46, P = 0.23; total model (F = 5.76, P = 0.0004).


CONCLUSIONS
Non-exercise physical activity is a correlate of motor symptom severity in PD independent of the magnitude of nigrostriatal degeneration. Non-exercise physical activity may have positive effects on functional performance in PD.
Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Jonathan
J
Snider
Department of Radiology, University of Michigan, Ann Arbor, MI, USA; University of Michigan, Morris K. Udall Center of Excellence for Parkinson's Disease, Ann Arbor, MI, USA.
Martijn L T M
ML
Müller
Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Vikas
V
Kotagal
Department of Radiology, University of Michigan, Ann Arbor, MI, USA; University of Michigan, Morris K. Udall Center of Excellence for Parkinson's Disease, Ann Arbor, MI, USA.
Robert A
RA
Koeppe
Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Peter J H
PJ
Scott
Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Kirk A
KA
Frey
Department of Neurology, University of Michigan, Ann Arbor, MI, USA; University of Michigan, Morris K. Udall Center of Excellence for Parkinson's Disease, Ann Arbor, MI, USA; Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA.
Roger L
RL
Albin
Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA; University of Michigan, Morris K. Udall Center of Excellence for Parkinson's Disease, Ann Arbor, MI, USA; Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA. Electronic address: nbohnen@umich.edu.
Nicolaas I
NI
Bohnen
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009410:Nerve Degeneration / Q000000981:diagnostic imaging; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D057185:Sedentary Behavior; D011795:Surveys and Questionnaires
Dopamine; Exercise; PET; Parkinson disease; Physical activity; Sedentariness