Effects of fibroblast growth factor 21 on the heart.
Fibroblast growth factor 21 (FGF21) is a novel polypeptide ligand that has been shown to be involved in several physiological and pathological processes including regulation of glucose and lipids as well as reduction of arteriosclerotic plaque formation in the great vessels. It has also been shown to exert cardioprotective effects in myocardial infarction, cardiac ischemia-reperfusion injury, cardiac hypertrophy and diabetic cardiomyopathy. Moreover, FGF21 protects the myocardium and great arteries by attenuating remodeling, inflammation, oxidative stress and also promoting the energy supply to the heart through fatty acid β-oxidation. This growing evidence emphasizes the important roles of FGF21 in cardioprotection. This review comprehensively summarizes and discusses the consistent and inconsistent findings regarding the beneficial effects of FGF21 on the heart available from both basic research and clinical reports. The details of the signaling, biological and pharmacological effects of FGF21 with regard to its protection of the heart are also presented and discussed in this review.
Cardiac Electrophysiology Research and Training CenterFaculty of MedicineCardiac Electrophysiology UnitDepartment of Physiology, Faculty of MedicineCenter of Excellence in Cardiac Electrophysiology ResearchDepartment of Oral Biology and Diagnostic SciencesFaculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand Cardiac Electrophysiology Research and Training CenterFaculty of MedicineCardiac Electrophysiology UnitDepartment of Physiology, Faculty of MedicineCenter of Excellence in Cardiac Electrophysiology ResearchDepartment of Oral Biology and Diagnostic SciencesFaculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Pongpan
P
Tanajak
Cardiac Electrophysiology Research and Training CenterFaculty of MedicineCardiac Electrophysiology UnitDepartment of Physiology, Faculty of MedicineCenter of Excellence in Cardiac Electrophysiology ResearchDepartment of Oral Biology and Diagnostic SciencesFaculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand Cardiac Electrophysiology Research and Training CenterFaculty of MedicineCardiac Electrophysiology UnitDepartment of Physiology, Faculty of MedicineCenter of Excellence in Cardiac Electrophysiology ResearchDepartment of Oral Biology and Diagnostic SciencesFaculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand Cardiac Electrophysiology Research and Training CenterFaculty of MedicineCardiac Electrophysiology UnitDepartment of Physiology, Faculty of MedicineCenter of Excellence in Cardiac Electrophysiology ResearchDepartment of Oral Biology and Diagnostic SciencesFaculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Siriporn C
SC
Chattipakorn
Cardiac Electrophysiology Research and Training CenterFaculty of MedicineCardiac Electrophysiology UnitDepartment of Physiology, Faculty of MedicineCenter of Excellence in Cardiac Electrophysiology ResearchDepartment of Oral Biology and Diagnostic SciencesFaculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand Cardiac Electrophysiology Research and Training CenterFaculty of MedicineCardiac Electrophysiology UnitDepartment of Physiology, Faculty of MedicineCenter of Excellence in Cardiac Electrophysiology ResearchDepartment of Oral Biology and Diagnostic SciencesFaculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand Cardiac Electrophysiology Research and Training CenterFaculty of MedicineCardiac Electrophysiology UnitDepartment of Physiology, Faculty of MedicineCenter of Excellence in Cardiac Electrophysiology ResearchDepartment of Oral Biology and Diagnostic SciencesFaculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand ncchattip@gmail.com.
Nipon
N
Chattipakorn
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D002316:Cardiotonic Agents / Q000494:pharmacology; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D032342:Muscle Cells / Q000187:drug effects / Q000502:physiology; D009203:Myocardial Infarction / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects
D002316:Cardiotonic Agents; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors
cardiac metabolism; fibroblast growth factor 21; myocardial injury; oxidative stress