Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice.
Extra-virgin olive oil (EVOO) is one of the main elements of Mediterranean diet. Several studies have suggested that EVOO has several health promoting effects that could protect from and decrease the risk of Alzheimer's disease (AD). In this study, we investigated the effect of consumption of EVOO-enriched diet on amyloid- and tau-related pathological alterations that are associated with the progression of AD and cerebral amyloid angiopathy (CAA) in TgSwDI mice. Feeding mice with EVOO-enriched diet for 6months, beginning at an age before amyloid-β (Aβ) accumulation starts, has significantly reduced total Aβ and tau brain levels with a significant improvement in mouse cognitive behavior. This reduction in brain Aβ was explained by the enhanced Aβ clearance pathways and reduced brain production of Aβ via modulation of amyloid-β precursor protein processing. On the other hand, although feeding mice with EVOO-enriched diet for 3months, beginning at an age after Aβ accumulation starts, showed improved clearance across the blood-brain barrier and significant reduction in Aβ levels, it did not affect tau levels or improve cognitive functions of TgSwDI mouse. Collectively, results of this study suggest that the long-term consumption of EVOO-containing diet starting at early age provides a protective effect against AD and its related disorder CAA.
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Hisham
H
Qosa
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Loqman A
LA
Mohamed
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Yazan S
YS
Batarseh
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Saeed
S
Alqahtani
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Baher
B
Ibrahim
Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
Harry
H
LeVine
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70803, USA.
Jeffrey N
JN
Keller
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA. Electronic address: kaddoumi@ulm.edu.
Amal
A
Kaddoumi
D000544:Alzheimer Disease / Q000378:metabolism; D000682:Amyloid / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D016657:Cerebral Amyloid Angiopathy; D003071:Cognition; D038441:Diet, Mediterranean; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008833:Microcirculation; D000069463:Olive Oil / Q000627:therapeutic use*; D016875:tau Proteins / Q000378:metabolism*
D000682:Amyloid; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; C558298:Mapt protein, mouse; D000069463:Olive Oil; D016875:tau Proteins
Amyloid-β; Blood–brain barrier; Clearance; Extra-virgin olive oil; Tau