Self-Assembling Peptide Nanofibrous Hydrogel as a Versatile Drug Delivery Platform.
Molecular hydrogels have been widely explored in various biomedical applications, such as cell culture, tissue engineering and drug delivery. Peptide-based hydrogel nanoparticles represent a promising alternative to current drug delivery approaches and cell carriers for tissue engineering, due to their encapsulation stability, water solubility and biocompatibility. This review focuses on recent advances in the use of self-assembling peptide nanogels for applications in drug delivery. We firstly introduce a self-assembly mechanism for small molecules used in the peptide hydrogel, and then describe recent methods for controlling the assembly of molecular hydrogelations. A particular emphasis is placed on recent advances in the use of different types of peptide hydrogels as drug delivery carriers. Lastly, the current challenges and future perspectives for self-assembling peptide hydrogels in drug delivery applications are discussed.
Zhiqiang
Z
Yu
Quan
Q
Xu
Chenbo
C
Dong
Su Seong
SS
Lee
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, 138669, Singapore. lqgao@ibn.a-star.edu.sg.
Liqian
L
Gao
Yiwen
Y
Li
Mathew
M
D'Ortenzio
Jun
J
Wu
D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage* / Q000627:therapeutic use; D057139:Nanofibers / Q000008:administration & dosage* / Q000627:therapeutic use; D010455:Peptides / Q000008:administration & dosage* / Q000627:therapeutic use
D004337:Drug Carriers; D020100:Hydrogels; D010455:Peptides