[Migration and pathogenicity of CD8 T cells in central nervous system diseases].
The implication of CD8 T cells in infectious and inflammatory diseases of the central nervous system has received increasing attention. CD8 T cells are crucial players of the adaptive immune system against neurotropic infections, but can also trigger tissue damage. Here we review the molecular mechanisms used by CD8 T cells to migrate into the central nervous system, and describe diseases that imply CD8 T cell-mediated pathogenicity. We also suggest therapeutic strategies targeting this population.
Département des maladies infectieuses et tropicales, hôpital universitaire de Toulouse, France - Inserm U1043, CNRS UMR 5282, centre de physiopathologie Toulouse-Purpan, hôpital Purpan, place du Docteur Baylac, 31024 Toulouse, France - Université Toulouse III, Toulouse, F-31000, France.
Guillaume
G
Martin-Blondel
Inserm U1043, CNRS UMR 5282, centre de physiopathologie Toulouse-Purpan, hôpital Purpan, place du Docteur Baylac, 31024 Toulouse, France - Département des neurosciences, hôpital universitaire de Toulouse, France.
Béatrice
B
Pignolet
Inserm U1043, CNRS UMR 5282, centre de physiopathologie Toulouse-Purpan, hôpital Purpan, place du Docteur Baylac, 31024 Toulouse, France - Université Toulouse III, Toulouse, F-31000, France.
Roland S
RS
Liblau
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D002465:Cell Movement; D002493:Central Nervous System Diseases / Q000276:immunology*; D006801:Humans