The many roles of glutamate in metabolism.
The amino acid glutamate is a major metabolic hub in many organisms and as such is involved in diverse processes in addition to its role in protein synthesis. Nitrogen assimilation, nucleotide, amino acid, and cofactor biosynthesis, as well as secondary natural product formation all utilize glutamate in some manner. Glutamate also plays a role in the catabolism of certain amines. Understanding glutamate's role in these various processes can aid in genome mining for novel metabolic pathways or the engineering of pathways for bioremediation or chemical production of valuable compounds.
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Mark C
MC
Walker
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA. vddonk@illinois.edu.
Wilfred A
WA
van der Donk
D000818:Animals; D001673:Biodegradation, Environmental; D001688:Biological Products / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D060847:Metabolic Engineering; D053858:Metabolic Networks and Pathways; D009584:Nitrogen / Q000378:metabolism; D009711:Nucleotides / Q000096:biosynthesis
D001688:Biological Products; D009711:Nucleotides; D018698:Glutamic Acid; D009584:Nitrogen
Lanthipeptides; Lantibiotics; Natural products; Non-ribosomal peptide synthetase; Thiopeptides