Colchicine therapy in amyloidosis related with plasmacytic Castleman disease presenting with nephrotic syndrome.
Castleman disease (CD) is a neoplasm that presents with single or multiple lymphadenopathy. The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy. In this paper, we report a young man with plasmacytic type CD and amyloid A (AA) deposition who presented with intra-abdominal mass and nephrotic syndrome. He was successfully treated with colchicine following surgery.
Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
Saime
S
Paydas
Semra
S
Paydas
Melek
M
Ergin
D051997:ADP-ribosyl Cyclase 1 / Q000032:analysis; D000328:Adult; D000686:Amyloidosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D003078:Colchicine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D000685:Serum Amyloid A Protein / Q000032:analysis; D013997:Time Factors; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D008562:Membrane Glycoproteins; D000685:Serum Amyloid A Protein; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1; D003078:Colchicine