The relationship of breast density in mammography and magnetic resonance imaging in high-risk women and women with breast cancer.
OBJECTIVE
To evaluate the relationship between mammographic breast density (MBD), background parenchymal enhancement (BPE), and fibroglandular tissue (FGT) in women with breast cancer (BC) and at high risk for developing BC.


METHODS
Our institutional database was queried for patients who underwent mammography and MRI.


RESULTS
Four hundred three (85%) had BC and 72 (15%) were at high risk. MBD (P=.0005), BPE (P<.0001), and FGT (P=.02) were all higher in high-risk women compared to the BC group.


CONCLUSIONS
Higher levels of MBD, BPE and FGT are seen in women at higher risk for developing BC when compared to women with BC.
Department of Radiology, New York University Langone Medical Center, Perlmutter Cancer Center, 160 East 34th Street, New York, NY 10016, USA.
Marissa
M
Albert
Department of Surgery, New York University Langone Medical Center, Perlmutter Cancer Center, 160 East 34th Street, New York, NY 10016, USA.
Freya
F
Schnabel
Department of Surgery, New York University Langone Medical Center, Perlmutter Cancer Center, 160 East 34th Street, New York, NY 10016, USA.
Jennifer
J
Chun
Department of Surgery, New York University Langone Medical Center, Perlmutter Cancer Center, 160 East 34th Street, New York, NY 10016, USA.
Shira
S
Schwartz
Department of Radiology, New York University Langone Medical Center, Perlmutter Cancer Center, 160 East 34th Street, New York, NY 10016, USA.
Jiyon
J
Lee
Department of Radiology, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil 05024-000 SP.
Ana Paula
AP
Klautau Leite
Department of Radiology, New York University Langone Medical Center, Perlmutter Cancer Center, 160 East 34th Street, New York, NY 10016, USA. Electronic address: Linda.Moy@nyumc.org.
Linda
L
Moy
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000071060:Breast Density; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D042361:Mammary Glands, Human / Q000002:abnormalities; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
BPE; Breast cancer; Density; MRI