Disseminating Melanoma Cells Surf on Calcium Waves.
Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study we investigated the mechanism underlying calcium-mediated melanoma invasion and metastasis, and discovered that hyperactive Ca2+oscillation in melanoma cells promoted invasion and metastasis through promoting invadopodium formation and extracellular matrix remodeling.
Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute ; Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute.
Jianwei
J
Sun
Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute ; Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute.
Shengchen
S
Lin
Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute ; Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute.
Tyler
T
Keeley
Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute ; Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute.
Shengyu
S
Yang