[General anesthetics as a factor of effective neuroprotection in ischemic stroke models].
Stroke is the second leading cause of death in the world. Unfortunately, only a few drugs have been proved in clinical trials. Drug development of the last decade has been focused substantially on a promising and heterogeneous group of neuroprotective drugs. Hundreds of compounds were suggested as new putative neuroprotectors, which effectiveness was confirmed in preclinical trials only. At the present time discrepancy between results of preclinical studies and clinical trials requires careful analysis. One of the least evaluated and probably the most noticeable reasons is general anesthesia--an obligatory component of an overwhelming majority of existing animal stroke models. The aim of the review is to describe known mechanisms of common general anesthetics influence on ionotropic and metabotropic plasma membrane receptors, and key signal pathways involved in neuronal hypoxic-ischemic injury and survival.
Irkutsk State Medical University, Irkutsk, Russia.
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VS
Laletin
Irkutsk State Medical University, Irkutsk, Russia.
Y N
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Bykov
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D016477:Artifacts; D002545:Brain Ischemia / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018091:Receptors, AMPA / Q000235:genetics / Q000378:metabolism; D018079:Receptors, GABA / Q000235:genetics / Q000378:metabolism; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics / Q000378:metabolism; D018047:Receptors, Purinergic P1 / Q000235:genetics / Q000378:metabolism; D020521:Stroke / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D018696:Neuroprotective Agents; D018091:Receptors, AMPA; D018079:Receptors, GABA; D018094:Receptors, Metabotropic Glutamate; D018047:Receptors, Purinergic P1
general anesthetics; neuroprotection; signal pathways; stroke models