Spherulitic copper-copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor.
In this work, three different spherulitic nanostructures Cu-CuOA, Cu-CuOB, and Cu-CuOC were synthesized in water-in-oil microemulsions by varying the surfactant concentration (30 mM, 40 mM, and 50 mM, respectively). The structural and morphological characteristics of the Cu-CuO nanostructures were investigated by ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction, scanning electron microscopy, and high-resolution transmission electron microscopy techniques. The synthesized nanostructures were deposited on multiwalled carbon nanotube (MWCNT)-modified indium tin oxide (ITO) electrodes to fabricate a nonenzymatic highly sensitive amperometric glucose sensor. The performance of the ITO/MWCNT/Cu-CuO electrodes in the glucose assay was examined by cyclic voltammetry and chronoamperometric studies. The sensitivity of the sensor varied with the spherulite type; Cu-CuOA, Cu-CuOB, and Cu-CuOC exhibited a sensitivity of 1,229, 3,012, and 3,642 µA mM(-1)·cm(-2), respectively. Moreover, the linear range is dependent on the structure types: 0.023-0.29 mM, 0.07-0.8 mM, and 0.023-0.34 mM for Cu-CuOA, Cu-CuOB, and Cu-CuOC, respectively. An excellent response time of 3 seconds and a low detection limit of 2 µM were observed for Cu-CuOB at an applied potential of +0.34 V. In addition, this electrode was found to be resistant to interference by common interfering agents such as urea, cystamine, L-ascorbic acid, and creatinine. The high performance of the Cu-CuO spherulites with nanowire-to-nanorod outgrowths was primarily due to the high surface area and stability, and good three-dimensional structure. Furthermore, the ITO/MWCNT/Cu-CuOB electrode applied to real urine and serum sample showed satisfactory performance.
Department of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of South Korea.
Gautam
G
Das
Department of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of South Korea.
Thao Quynh Ngan
TQ
Tran
Department of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of South Korea.
Hyon Hee
HH
Yoon
D015374:Biosensing Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D004566:Electrodes; D005947:Glucose / Q000032:analysis / Q000737:chemistry; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*
D003300:Copper; D005947:Glucose; C000520:cuprous oxide
copper oxide; cyclic voltammetry; glucose sensor; multiwalled carbon nanotubes