The Path from Pluripotency to Skeletal Muscle: Developmental Myogenesis Guides the Way.
Following cues from mouse embryogenesis, Chal et al. (2015) identified key regulators of skeletal myogenesis from mouse and human pluripotent stem cells. Emerging myogenic progenitors were specified to form multinucleated fibers that enabled development of quiescent, satellite cell-like progenitors and a model for Duchenne Muscular Dystrophy.
Department of Microbiology, Immunology and Molecular Genetics, Center for Duchenne Muscular Dystrophy, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095, USA.
Michael
M
Hicks
Department of Microbiology, Immunology and Molecular Genetics, Center for Duchenne Muscular Dystrophy, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095, USA. Electronic address: apyle@mednet.ucla.edu.
April
A
Pyle
D000818:Animals; D002454:Cell Differentiation; D004195:Disease Models, Animal; D018485:Muscle Fibers, Skeletal / Q000473:pathology*; D020388:Muscular Dystrophy, Duchenne / Q000473:pathology*; D039904:Pluripotent Stem Cells / Q000473:pathology*