Poorly differentiated thyroid carcinoma: a retrospective clinicopathological study.
Poorly differentiated thyroid carcinoma (PDTC) is an independent thyroid cancer histotype. In spite of its scarcity, it represents the main cause of death from non-anaplastic follicular cell-derived thyroid cancer. However, given the newness of this entity, few data are available on its clinical behaviour and no explicit consensus sets its treatment. To report the experience of a tertiary medical centre in morocco with PDTC over a period of 7 years. Retrospective study selecting all patients treated for thyroid carcinoma in Nuclear Medicine Department of a tertiary medical centre in Casablanca over seven years period. Patient's files were reviewed for background data, clinico-pathological characteristics, treatment and outcome. Seven patients were included in the study. Patient's average age was 60 years old (30-81) including six women and one man. All patients underwent a total thyroidectomy completed by cervical lymph node dissection in 57% of cases. Mean primary tumour size was 4cm (1-9cm). Patients were classified pT3 in 70% of cases, pT1 and pT2 in 15% each. Vascular invasion was found in 85% of cases. Pathological subtypes found were "insular carcinoma" in 85% of cases. Radioiodine therapy (RIT) was indicated in all cases. Follow-up period ranged between 10 months and 6 years. It showed a complete remission in 57% of cases, persistent disease in 28% of cases and a progressive disease in 15% of cases with a local recurrence. To date, the survival rate is 85%. PDTC is an aggressive thyroid cancer histotype. Treatment remains surgical followed by RIT if the tumour is radioavid. Multimodality therapy is indicated depending on the case and close monitoring is always indicated given the high risk of relapse.
Nuclear Medicine Department, Ibn Rochd University Hospital, Université Hassan II, Casablanca, Morocco.
Ghofrane Salhi
GS
Cherkaoui
Nuclear Medicine Department, Ibn Rochd University Hospital, Université Hassan II, Casablanca, Morocco.
Amal
A
Guensi
Nuclear Medicine Department, Ibn Rochd University Hospital, Université Hassan II, Casablanca, Morocco.
Sara
S
Taleb
Nuclear Medicine Department, Ibn Rochd University Hospital, Université Hassan II, Casablanca, Morocco.
Malika Ait
MA
Idir
Emergency Radiology Department, Ibn Rochd University Hospital, Université Hassan II Casablanca, Morocco.
Najwa
N
Touil
Emergency Radiology Department, Ibn Rochd University Hospital, Université Hassan II Casablanca, Morocco.
Rita
R
Benmoussa
Emergency Radiology Department, Ibn Rochd University Hospital, Université Hassan II Casablanca, Morocco.
Zaineb
Z
Baroudi
Emergency Radiology Department, Ibn Rochd University Hospital, Université Hassan II Casablanca, Morocco.
Nabil
N
Chikhaoui
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009018:Morocco; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D015996:Survival Rate; D062606:Tertiary Care Centers; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods*; D016896:Treatment Outcome
Thyroid neoplasms; diagnosis; poorly differentiated thyroid carcinoma; treatment