Radial glial cells organize the central nervous system via microtubule dependant processes.
The correct cytokinesis and polarization of radial glial cells are essential for populating and patterning the central nervous system. The microtubule (MT) cytoskeleton is central to regulating glial and neuronal functions during development and in the adult, providing the dynamic ability to extend processes, migrate, establish synaptic connections and transmit information. MT biogenesis disorders result in a spectrum of neurological deficits resulting from abnormal neuronal proliferation, migration and aberrant white matter formation. In the present review, we place a spotlight on the roles MTs play in orchestrating radial glial cell activities during interkinetic nuclear migration and neuronal translocation to cortical destinations along pia-directed processes. We also outline the consequences of MT dysfunction in the polarization and establishment of the radial glial cell scaffold.
Department of Anatomy, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin 2, Ireland.
Jessica
J
Nulty
Department of Anatomy, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin 2, Ireland.
Mohamed
M
Alsaffar
Department of Anatomy, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin 2, Ireland. Electronic address: debarry@tcd.ie.
Denis
D
Barry
D000818:Animals; D002490:Central Nervous System / Q000166:cytology*; D063928:Ependymoglial Cells / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000502:physiology*
Centrosome; Lissencephaly; Microtubule; Neuron; Radial glial cell