The myelin oligodendrocyte glycoprotein directly  binds nerve growth factor to modulate central axon  circuitry.
Myelin oligodendrocyte glycoprotein (MOG) is a central nervous system myelin-specific molecule expressed on the outer lamellae of myelin. To date, the exact function of MOG has remained unknown, with MOG knockout mice displaying normal myelin ultrastructure and no apparent specific phenotype. In this paper, we identify nerve growth factor (NGF) as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF from TrkA-expressing neurons to modulate axon growth and survival. Deletion of MOG results in aberrant sprouting of nociceptive neurons in the spinal cord. Binding of NGF to MOG may offer widespread implications into mechanisms that underlie pain pathways.
H-Christian
HC
von Büdingen
Feng
F
Mei
Ariele
A
Greenfield
Sarah
S
Jahn
Yun-An A
YA
Shen
Hugh H
HH
Reid
David D
DD
McKemy
Jonah R
JR
Chan
D000595:Amino Acid Sequence; D000818:Animals; D001369:Axons / Q000378:metabolism*; D016466:CHO Cells; D002470:Cell Survival; D018920:Coculture Techniques; D003412:Cricetulus; D005727:Ganglia, Spinal / Q000378:metabolism* / Q000473:pathology; D005838:Genotype; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D020932:Nerve Growth Factor / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism*; D010641:Phenotype; D011485:Protein Binding; D017207:Rats, Sprague-Dawley; D020917:Receptor, trkA / Q000378:metabolism; D015398:Signal Transduction; D013116:Spinal Cord / Q000378:metabolism* / Q000473:pathology; D014162:Transfection
C571327:Mog protein, mouse; C571328:Mog protein, rat; D063308:Myelin-Oligodendrocyte Glycoprotein; D020932:Nerve Growth Factor; D020917:Receptor, trkA