Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis.
Association studies of interleukin-6 (IL-6) -174G>C polymorphism and chronic obstructive pulmonary disease (COPD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. A comprehensive search was performed in the PubMed, Embase, Elsevier, Web of Science databases, Wanfang, and the Chinese National Knowledge Infrastructure (CNKI) databases for published studies investigating the associations between IL-6 -174G>C polymorphism and COPD. Odds ratios (OR) and 95% confidence intervals (95%CI) were used to assess the possible associations. Seven studies with a total of 2701 subjects were included in this meta-analysis. A significantly increased risk was detected in the C allele of the IL-6 -174G>C in Caucasians (C vs G: OR = 1.16, 95%CI = 1.03-1.30; CC+GC vs GG: OR = 1.21, 95%CI = 1.02-1.42; CC vs GG: OR = 1.32, 95%CI = 1.03-1.70). This meta-analysis suggests that the C allele of the IL-6 -174G>C might act as a COPD risk factor in Caucasians. Further well-designed case-control studies with larger sample sizes are needed to confirm these conclusions.
Department of Respiratory Medicine, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
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Xie
Department of Respiratory Medicine, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
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Ke
Department of Respiratory Medicine, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
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YH
Zhang
Department of Respiratory Medicine, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
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GZ
Wang
Department of Respiratory Medicine, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
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YT
Zhu
Department of Respiratory Medicine, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
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Hussian
Department of Respiratory Medicine, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
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Yang
Department of Respiratory Medicine, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China manxiangli@hotmail.com.
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Li
D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
C508600:IL6 protein, human; D015850:Interleukin-6