[Mitomycin extravasation after postoperative instillation].
OBJECTIVE
To present the therapeutic management of severe complications related to postoperative mitomycin extravasation.


METHODS
Description of clinical cases, medical and surgical management and pathologic results of surgical specimens.


RESULTS
We report two cases of patients with extravesical mitomycin leakage after postoperative instillation. No bladder perforation was evident during tumor surgery. In both cases radical cystectomy was required.


CONCLUSIONS
Postoperative mitomycin instillation may have undesirable consequences. The possible problems derived from its administration must be known, and each case must be individualized before administering this chemotherapy.
Urology Department. Hospital Clínico Universitario de Valencia. Valencia. Spain.
Jorge
J
Panach-Navarrete
Urology Department. Hospital Universitario de la Ribera. Valencia. Spain.
Cristina
C
Ferrandis-Cortés
Anatomo-Pathological Department. Hospital Clínico Universitario de Valencia. Valencia. Spain.
María Ángeles
MÁ
Sales-Maicas
Urology Department. Hospital Clínico Universitario de Valencia. Valencia. Spain.
José María
JM
Martínez-Jabaloyas
D000283:Administration, Intravesical; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000175:diagnosis / Q000601:surgery; D012422:Rupture, Spontaneous; D001745:Urinary Bladder Diseases / Q000175:diagnosis / Q000601:surgery
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin