Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents.
Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce phototoxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).
Department of Chemistry, QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal. jtome@ua.pt.
N
N
Venkatramaiah
Patrícia M R
PM
Pereira
Filipe A
FA
Almeida Paz
Carlos A F
CA
Ribeiro
Rosa
R
Fernandes
João P C
JP
Tomé
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D054833:Isoindoles; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D015394:Molecular Structure; D010757:Phosphorous Acids / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D055293:Receptors, Urokinase Plasminogen Activator / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007211:Indoles; D054833:Isoindoles; D010757:Phosphorous Acids; D017319:Photosensitizing Agents; D055293:Receptors, Urokinase Plasminogen Activator; C570063:phosphonic acid; D020780:Matrix Metalloproteinase 9; C013647:phthalocyanine