α-Glucosidase Inhibition and Antihyperglycemic Activity of Phenolics from the Flowers of Edgeworthia gardneri.
The flowers of Edgeworthia gardneri are consumed as an herbal tea in Tibet with potential health benefits. To complement the current knowledge regarding the chemical composition and antihyperglycemic activity of the flower of E. gardneri, two new phenolics, gardnerol A and B (1 and 2), along with 19 known phenolics were isolated from the flower of E. gardneri. All isolates were evaluated for their inhibitory activity against α-glucosidase. Compound 5, identified as the major constituent of the flower of E. gardneri, showed a significant α-glucosidase inhibitory activity and acted as a competitive inhibitor. The oral administration of compound 5 at a dose of 300 mg/kg significantly reduced the postprandial blood glucose levels of normal and streptozotocin (STZ)-induced diabetic mice. Furthermore, compound 5 significantly decreased the fasting blood glucose levels in STZ-induced diabetic mice.
College of Light Industry and Chemical Engineering, Guangdong University of Technology , Guangzhou, Guangdong 510006, People's Republic of China.
Yan-Yan
YY
Ma
College of Light Industry and Chemical Engineering, Guangdong University of Technology , Guangzhou, Guangdong 510006, People's Republic of China.
Deng-Gao
DG
Zhao
College of Light Industry and Chemical Engineering, Guangdong University of Technology , Guangzhou, Guangdong 510006, People's Republic of China.
Ai-Yu
AY
Zhou
School of Chemistry and Environment Engineering, Wuyi University , Jiangmen, Guangdong 529020, People's Republic of China.
Yu
Y
Zhang
College of Light Industry and Chemical Engineering, Guangdong University of Technology , Guangzhou, Guangdong 510006, People's Republic of China.
Zhiyun
Z
Du
College of Light Industry and Chemical Engineering, Guangdong University of Technology , Guangzhou, Guangdong 510006, People's Republic of China.|School of Chemistry and Environment Engineering, Wuyi University , Jiangmen, Guangdong 529020, People's Republic of China.
Kun
K
Zhang
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D005215:Fasting; D035264:Flowers / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D015394:Molecular Structure; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D019518:Postprandial Period; D029645:Thymelaeaceae / Q000737:chemistry*; D000520:alpha-Glucosidases
D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010636:Phenols; D000520:alpha-Glucosidases
Edgeworthia gardneri; antihyperglycemic activity; herbal tea; phenolics; α-glucosidase inhibitor