What are the effects of hypertonic saline plus furosemide in acute heart failure?
In search of new therapies to solve diuretic resistance in acute heart failure, the addition of hypertonic saline has been proposed. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified two systematic reviews including nine pertinent randomized controlled trials. We combined the evidence and generated a summary of findings following the GRADE approach. We concluded hypertonic saline associated with furosemide probably decrease mortality, length of hospital stay and hospital readmission in patients with acute decompensated heart failure.
Programa de Salud Basada en Evidencia, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile, Lira 63, Santiago Centro, Chile. Email: pasepulveda@med.puc.cl.
Patricio
P
Zepeda
Programa de Salud Basada en Evidencia, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos.
Carmen
C
Rain
Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos.
Paola
P
Sepúlveda
D000208:Acute Disease; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use; D005665:Furosemide / Q000008:administration & dosage* / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D007902:Length of Stay; D010359:Patient Readmission; D016032:Randomized Controlled Trials as Topic; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*
D004232:Diuretics; D012462:Saline Solution, Hypertonic; D005665:Furosemide