Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities.
Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A-C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.
School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China. lvqing@mail.kib.ac.cn.|State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China. lvqing@mail.kib.ac.cn.
Juan
J
Lu
School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China. sdy-0502@126.com.
Qin
Q
Sun
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Road, Guangzhou 510530, China. tu_zhengchao@gibh.ac.cn.
Zheng-Chao
ZC
Tu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China. lvqing@mail.kib.ac.cn.
Qing
Q
Lv
School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China. spx6702@163.com.
Pi-Xian
PX
Shui
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China. yxcheng@mail.kib.ac.cn.
Yong-Xian
YX
Cheng
D000818:Animals; D002460:Cell Line; D001517:Coleoptera / Q000737:chemistry / Q000378:metabolism*; D051545:Cyclooxygenase 1 / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004285:Dogs; D004298:Dopamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry / Q000494:pharmacology; D061986:MCF-7 Cells; D061985:Madin Darby Canine Kidney Cells; D015394:Molecular Structure
D004791:Enzyme Inhibitors; D019476:Insect Proteins; C006374:N-acetyldopamine; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D004298:Dopamine
COX-1; COX-2; Catharsius molossus; N-acetyldopamine dimers