[Nitric oxide and electrogenic metals (Ca, Na, K) in epidermal cells].
Using atomic emission spectrometry and EPR analysis metal-ligand homeostasis (MLH) has been studied in epidermal cells of 954 liquidators of the Chernobyl accident and 947 healthy individuals. A possible association of the redox status with the quantitative changes in the MLH, which could be used as discriminators of oxidative/nitrosative stress, attracts special interest. Characteristic features of oxidative stress mainly related to electrogenic metals (Ca, K, Na), were found not only among the liquidators examined, but also in some healthy individuals (18.1%); this suggests the presence of oxidative/nitrosative stress of non-radiation origin. Correlation between intracellular production of nitric oxide (NO) with quantitative changes in the electrogenic metals may indicate the possible involvement of NO in the generation of an electric potential of the cell.
Baltic Institute of Psychology, Riga, Latvia.
V I
VI
Petukhov
Latvian Institute of Organic Synthesis, Riga, Latvia.
L K
LK
Baumane
Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia.
E V
EV
Dmitriev
A.Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
A F
AF
Vanin
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent; D002414:Cations, Monovalent; D047852:Chernobyl Nuclear Accident; D002648:Child; D002675:Child, Preschool; D004578:Electron Spin Resonance Spectroscopy; D004817:Epidermis / Q000378:metabolism / Q000528:radiation effects*; D005260:Female; D006197:Hair / Q000378:metabolism / Q000528:radiation effects*; D006801:Humans; D017136:Ion Transport; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011188:Potassium / Q000378:metabolism*; D000069079:Radiation Exposure; D011839:Radiation, Ionizing; D012964:Sodium / Q000378:metabolism*; D013997:Time Factors
D002413:Cations, Divalent; D002414:Cations, Monovalent; D009569:Nitric Oxide; D012964:Sodium; D011188:Potassium; D002118:Calcium
epidermis; metal-ligand homeostasis; nitric oxide; redox status