Biological variations of seven tumor markers.
BACKGROUND
We sought to identify biological variations in the following tumor markers: pepsinogen I (PGI), pepsinogen II (PGII), carbohydrate antigen 724 (CA724), neuron-specific enolase (NSE), pro-gastrin-releasing peptide (ProGRP), carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199).


METHODS
Serum samples were collected from 20 healthy Chinese individuals over 5 days. Samples were then screened for the presence of the seven aforementioned tumor markers. Within-individual coefficient of variation (CVI), between-individual coefficient of variation (CVG), confidence interval (CI) of biological variations, index of individuality (II), and the reference change value (RCV) of the seven tumor markers were calculated.


RESULTS
Of the 7 tumor markers, index of individuality was all <1.0. ProGRP showed the lowest CVI and CVG, at 4.75% (CI: 3.96%-5.94%) and 16.42% (CI: 12.32%-24.61%), respectively. The 95% and 99% RCVs for ProGRP were 14.68 and 19.32, respectively, and were the lowest of the markers. In contrast, the CVI and CVG for CA724 were the highest, at 16.06% (CI: 13.83%-19.17%) and 96.95% (CI: 73.73%-141.59%), respectively. The 95% and 99% RCVs for CA724 were the highest, at 45.89 and 60.41, respectively.


CONCLUSIONS
Our findings provide additional information regarding the biological variation of tumor markers, and could be applied in a clinical setting.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Zhihong
Z
Qi
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Lin
L
Zhang
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Yu
Y
Chen
Institute of Basic Medicine Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China.
Xinming
X
Ma
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Xuehui
X
Gao
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Juan
J
Du
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Fang
F
Zhang
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Xinqi
X
Cheng
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. Electronic address: wendycuiwei@sina.cn.
Wei
W
Cui
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001774:Blood Chemical Analysis / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D013997:Time Factors; D055815:Young Adult
D014408:Biomarkers, Tumor
Biological variation; Index of individuality; Reference change value; Tumor marker