[Chemotherapy-induced Peripheral Neuropathy].
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and relevant side effect of antineoplastic agents such as cisplatin, paclitaxel, vincristine and bortezomib. Over the last years, significant progress has been achieved in elucidating the underlying pathomechanisms of CIPN using both in vivo and in vitro models. These studies suggest that mitochondrial toxicity, disturbed axonal transport, toxic effects on Schwann cells and activation of the immune system contribute to the pathogenesis of CIPN. This review provides an overview of the current pathogenetic concepts of CIPN. In addition, experimental approaches that aim at preventing or ameliorating neurotoxic effects of antineoplastic agents are discussed.
Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln.
I
I
Bobylev
Klinik für Innere Medizin I, Universitätsklinikum Köln.
T
T
Elter
Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln.
C
C
Schneider
Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln.
G
G
Wunderlich
Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Köln.
P
P
Zimmer
Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Köln.
F
F
Streckmann
Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln.
G R
GR
Fink
Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln.
H C
HC
Lehmann
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy
D000970:Antineoplastic Agents