Platelet-rich plasma for resistant oral erosions of pemphigus vulgaris: A pilot study.
Oral erosions and ulcers of pemphigus vulgaris (PV) are a debilitating condition that is usually difficult to treat. The wound healing properties of platelet-rich plasma (PRP) encouraged us to evaluate its usefulness in treatment of non-healing oral PV lesions. Seven patients with chronic oral PV, resistant to conventional therapy, were treated with weekly to monthly injections of PRP of affected mucosal membranes. All recruits reported improvement in pain and mastication and 6 of 7 patients had an improvement in pemphigus disease area index scores with PRP treatment. PRP injections seems to accelerate the healing process and decrease the pain and eating discomfort associated with the oral erosions and ulcers induced by PV.
Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.
Mohamed Hussein Medhat
MH
EL-Komy
Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.
Akmal Saad
AS
Hassan
Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.
Heba Mohammed
HM
Abdel Raheem
Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.
Sally Sameh
SS
Doss
Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.
Mona
M
EL-Kaliouby
Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.
Noha Adly
NA
Saleh
Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.
Marwah Adly
MA
Saleh
D000328:Adult; D002908:Chronic Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000503:physiopathology / Q000628:therapy*; D017060:Patient Satisfaction; D010392:Pemphigus / Q000503:physiopathology / Q000628:therapy*; D010865:Pilot Projects; D053657:Platelet-Rich Plasma; D016896:Treatment Outcome; D014945:Wound Healing