Expression of CD147, PCNA, VEGF, MMPs and their clinical significance in the giant cell tumor of bones.
BACKGROUND
Giant cell tumor of bone (GCT) is a potentially malignant tumor. CD147 is a multifunctional protein, which expresses itself in many tumors. In this study, we have investigated the correlation between CD147 and PCNA, VEGF, MMPs expression in giant cell tumor of bones. We have also explored the relationship between its clinical pathology and prognosis.


RESULTS
A significant difference of the expression level of CD147, MMPs was found in cases of GCT with Jaffe grading and prognosis (P<0.05). But, it was not in accordance with the patient's age and sex. An expression of CD147 was positively correlated with MMP-9, VEGF, MVD, PCNA (r=0.271, P=0.025; r=0.411, P=0.000; r=0.872, P=0.000; r=0.394, P=0.001).


CONCLUSIONS
The expression level of CD147 in giant cell tumors of bones is correlated with the development of cancers and relapse. There was a positive correlation between expressions of CD147 and MMP-9, VEGF, MVD, PCNA, and CD147. This is an important indicator in evaluating the malignant degree and prognosis of giant cell tumors of bone. It may be the new target for ensuring chemopreventive strategies.
Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University Xi'an, People's Republic of China.
Yue-Hu
YH
Han
Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University Xi'an, People's Republic of China.
Bo
B
Gao
Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University Xi'an, People's Republic of China.
Jing-Hui
JH
Huang
Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University Xi'an, People's Republic of China.
Zhen
Z
Wang
Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University Xi'an, People's Republic of China.
Zheng
Z
Guo
Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University Xi'an, People's Republic of China.
Qiang
Q
Jie
Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University Xi'an, People's Republic of China.
Liu
L
Yang
Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University Xi'an, People's Republic of China.
Zhuo-Jing
ZJ
Luo
D000293:Adolescent; D000328:Adult; D051926:Basigin / Q000032:analysis*; D001859:Bone Neoplasms / Q000737:chemistry* / Q000473:pathology; D002648:Child; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D008875:Middle Aged; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*; D055815:Young Adult
C497886:BSG protein, human; D018809:Proliferating Cell Nuclear Antigen; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D051926:Basigin; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
EMMPRIN; Giant cell tumor of bone; MMP; extracellular matrix metalloproteinases inducer; immunohistochemistry; matrix metalloproteinases; vascular endothelial growth factor