Dosage Form Developments of Nanosuspension Drug Delivery System for Oral Administration Route.
A large amount of new drug candidates are practically insoluble in aqueous solvents and are even simultaneously poorly soluble in organic solvents. Nanosuspension drug delivery system (DDS) was firstly developed in 1994 and has attracted more and more attention as a formation solution for the poorly soluble drugs. By nansizing the poorly soluble drugs, nanosuspensions have several outstanding advantages for drug delivery. Among many administration routes of drug delivery, oral administration is the most preferred route due to its advantages such as ease of ingestion, versatility to accommodate various types of drug candidates, low production cost, high safety, good patient compliance, and pain avoidance. Current marketed pharmaceutical nanosuspension DDS products are mostly for oral administration. This review is to systematically summarize the nanosuspension DDS dosage form developments of poorly soluble drugs for oral administration use.
Ang
A
Chen
Ye
Y
Shi
Zhiqiang
Z
Yan
Hongxun
H
Hao
Yong
Y
Zhang
Jian
J
Zhong
College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, People's Republic of China. huimin328@hotmail.com.
Huiming
H
Hou
D000284:Administration, Oral; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000008:administration & dosage / Q000627:therapeutic use; D013535:Suspensions / Q000008:administration & dosage
D013535:Suspensions