Clinical and Laboratory Features of Six Cases of Candida and Dermatophyte Folliculitis and a Review of Published Studies.
Although some studies have investigated the epidemiological characteristics of Malassezia folliculitis (MF), little is known about the clinical features and laboratory characteristics of folliculitis caused by other fungi. In this prospective study, 158 patients with folliculitis were identified, and cytological and mycological examinations were performed. The positive fungal cultures were confirmed using conventional methods, ITS sequencing and HWP1 analysis. Additionally, an in vitro antifungal susceptibility test was performed. Of 158 patients with folliculitis, 65 (41.1 %) were found to have fungal folliculitis. The most common (90.8 %) fungal folliculitis was MF. Non-MF fungal folliculitis was detected in 6 (9.2 %) patients. Four patients were diagnosed with dermatophytic folliculitis (Trichophyton rubrum in three patients and Arthroderma vanbreuseghemii in one patient), and two patients were diagnosed with Candida albicans folliculitis. Although only 5 of the 6 samples were found to be positive via a potassium hydroxide test, all May-Grünwald-Giemsa-stained samples were positive. Both of the C. albicans isolates demonstrated a susceptibility profile to itraconazole, and all four dermatophytes were susceptible to terbinafine. All six patients completely recovered with systemic and topical treatment. This study revealed that dermatophytes and C. albicans are the primary causative agents of non-Malassezia fungal folliculitis. We compared our findings with published reports on fungal folliculitis.
Department of Dermatology, Faculty of Medicine, Başkent University Adana Hospital, 01250, Adana, Turkey. sivandr@hotmail.com.
Murat
M
Durdu
Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.|Department of Microbiology, Faculty of Medicine, Eastern Mediterranean University, Famagusta, Cyprus, Mersin 10, Turkey.
Mümtaz
M
Güran
Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.
Hazal
H
Kandemir
Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.
Macit
M
Ilkit
Department of Medical Microbiology, Radboud UMC, Nijmegen, The Netherlands.|Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands.|Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Seyedmojtaba
S
Seyedmousavi
D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D003883:Arthrodermataceae / Q000145:classification / Q000302:isolation & purification*; D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D002675:Child, Preschool; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003881:Dermatomycoses / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology*; D005260:Female; D005499:Folliculitis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D011446:Prospective Studies; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer
Acantholytic cell; Candida folliculitis; Cytology; Dermatophytic folliculitis; Fungal folliculitis