A new avenue to the synthesis of GAG-mimicking polymers highly promoting neural differentiation of embryonic stem cells.
A new strategy for the fabrication of glycosaminoglycan (GAG) analogs was proposed by copolymerizing the sulfonated unit and the glyco unit, 'splitted' from the sulfated saccharide building blocks of GAGs. The synthetic polymers can promote cell proliferation and neural differentiation of embryonic stem cells with the effects even better than those of heparin.
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. yuanl@suda.edu.cn chenh@suda.edu.cn.
Mengmeng
M
Wang
Zhonglin
Z
Lyu
Gaojian
G
Chen
Hongwei
H
Wang
Yuqi
Y
Yuan
Kaiguo
K
Ding
Qian
Q
Yu
Lin
L
Yuan
Hong
H
Chen
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D053595:Embryonic Stem Cells / Q000187:drug effects*; D006025:Glycosaminoglycans / Q000737:chemistry*; D051379:Mice; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D006025:Glycosaminoglycans; D011108:Polymers