Atrophic gastritis with high prevalence of Helicobacter pylori is a predominant feature in patients with dyspepsia in a high altitude area.
BACKGROUND
Dyspepsia is a common symptom in residents of Leh, a high-altitude region in Ladakh, India. Helicobacter pylori related gastritis is a common cause of such symptoms. However data regarding this association at high altitudes is sparse.


OBJECTIVE
To investigate the demographic, endoscopic and histopathology findings in patients presenting with dyspeptic symptoms in the high-altitude region of Leh. Methods: A cross-sectional study was done in 84 patients with dyspeptic symptoms, attending the outpatient department of local government hospital in Leh. Demographic details, endoscopy, histopathology of upper gastrointestinal biopsies and microbiology culture of gastric/duodenal aspirates were studied.


RESULTS
The mean age was 38.4 years with 42% being males. Indigenous foods with high-salt content were consumed by 75% of patients. Epigastric pain was the most frequent symptom (in 96%) and pain radiating to the back was another peculiar symptom seen in 49% of patients. The predominant finding on endoscopy was antral gastritis in 71% of patients. Nodular gastritis was seen in 18% of patients. H. pylori was documented in 93% and histopathology revealed mild-to-moderate inflammation in 93% and mild-to-moderate atrophy in 90% of patients. Colonization with Gram-negative bacilli was observed in gastric/duodenal aspirate cultures.


CONCLUSIONS
Dyspepsia at high-altitude commonly presents as pain radiating to the back with a very high (90%) prevalence of H. pylori, endoscopic findings of antral gastritis and nodular gastritis, and atrophic gastritis in biopsies. Further investigations are needed to determine whether these observations are related to the high-altitude or the high-salt content in their diet and also whether these further translate to carcinogenesis.
Piyush Kumar
PK
Sharma
Tejas Menon
TM
Suri
Pratap Mouli
PM
Venigalla
Sushil Kumar
SK
Garg
Ghulam
G
Mohammad
Prasenjit
P
Das
Seema
S
Sood
Anoop
A
Saraya
Vineet
V
Ahuja
D000328:Adult; D000531:Altitude; D001706:Biopsy; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005757:Gastritis, Atrophic / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged