Acute kidney injury in pregnancy--a single center experience.
BACKGROUND
Acute kidney injury (AKI) is a serious complication in pregnancy, resulting in significant maternal morbidity/mortality and fetal loss. Although the incidence of pregnancy-related acute kidney injury (PRAKI) has decreased in developed countries, it is still common in developing nations.


METHODS
A prospective observational study was done between January 2010 and December 2014 to report the incidence, clinical spectrum, maternal and fetal outcome of AKI in pregnancy.


RESULTS
Total number of patients: 130; mean age: 25.4 ± 4.73 years. The incidence of AKI in pregnancy was 7.8%. Most of the AKI was noted in postpartum period (68%). Etiology of AKI was sepsis (39%), pre-eclampsia (21%), placental abruption (10%), acute diarrheal disease complicating pregnancy (10%), thrombotic microangiopathy (TMA) (9%), postpartum hemorrhage (2%) and glomerular diseases (9%). Renal biopsy (n = 46) done in these patients showed renal cortical necrosis (16), TMA (11), acute tubular injury (9), acute tubulointerstitial disease (1) and glomerular disease (9). Live births occurred in 42% of patients with vaginal delivery in 34% cases. Thirty-four patients were managed conservatively, while 96 required dialysis. Complete recovery occurred in 56% and about 36% had persistent renal failure at 3 months. Mortality rate observed was 8%. In univariate analysis, low mean platelet count, higher peak serum creatinine, dialysis dependency at presentation and histopathologically presence of cortical necrosis and TMA predicted the progression to chronic kidney disease.


CONCLUSIONS
AKI in pregnancy was common in postpartum period and sepsis being the commonest cause.
a Department of Nephrology , Madras Medical College & Rajiv Gandhi Government General Hospital , Chennai , India and.
Natarajan
N
Gopalakrishnan
a Department of Nephrology , Madras Medical College & Rajiv Gandhi Government General Hospital , Chennai , India and.
Jeyachandran
J
Dhanapriya
b Global Hospitals , Chennai , India.
Periyasamy
P
Muthukumar
a Department of Nephrology , Madras Medical College & Rajiv Gandhi Government General Hospital , Chennai , India and.
Ramanathan
R
Sakthirajan
a Department of Nephrology , Madras Medical College & Rajiv Gandhi Government General Hospital , Chennai , India and.
Thanigachalam
T
Dineshkumar
a Department of Nephrology , Madras Medical College & Rajiv Gandhi Government General Hospital , Chennai , India and.
S
S
Thirumurugan
a Department of Nephrology , Madras Medical College & Rajiv Gandhi Government General Hospital , Chennai , India and.
T
T
Balasubramaniyan
D000037:Abruptio Placentae; D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D001706:Biopsy; D003906:Developing Countries; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007673:Kidney Cortex Necrosis / Q000453:epidemiology / Q000473:pathology*; D006473:Postpartum Hemorrhage / Q000453:epidemiology; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000401:mortality*; D011446:Prospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000150:complications*; D057049:Thrombotic Microangiopathies / Q000150:complications; D055815:Young Adult
Acute kidney injury; chronic kidney disease; cortical necrosis; dialysis; pregnancy