Dynamic Nanoparticle-Based Flexible Sensors: Diagnosis of Ovarian Carcinoma from Exhaled Breath.
Flexible sensors based on molecularly modified gold nanoparticles (GNPs) were integrated into a dynamic cross-reactive diagnostic sensing array. Each bending state of the GNP-based flexible sensor gives unique nanoparticle spatial organization, altering the interaction between GNP ligands and volatile organic compounds (VOCs), which increases the amount of data obtainable from each sensor. Individual dynamic flexible sensor could selectively detect parts per billion (ppb) level VOCs that are linked with ovarian cancers in exhaled breath and discriminate them from environmental VOCs that exist in exhaled breath samples, but do not relate to ovarian cancer per se. Strain-related response successfully discriminated between exhaled breath collected from control subjects and those with ovarian cancer, with data from a single sensor being sufficient to obtain 82% accuracy, irrespective of important confounding factors, such as tobacco consumption and comorbidities. The approach raises the hope of achieving an extremely simple, inexpensive, portable, and noninvasive diagnostic procedure for cancer and other diseases.
Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology , Haifa 3200003, Israel.
Nicole
N
Kahn
Gynecological Oncology and Surgery Unit, Carmel Medical Center , Haifa 3436212, Israel.
Ofer
O
Lavie
Gynecological Oncology and Surgery Unit, Carmel Medical Center , Haifa 3436212, Israel.
Moran
M
Paz
Gynecological Oncology and Surgery Unit, Carmel Medical Center , Haifa 3436212, Israel.
Yakir
Y
Segev
Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology , Haifa 3200003, Israel.
Hossam
H
Haick
D001944:Breath Tests; D005260:Female; D006046:Gold / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D055549:Volatile Organic Compounds / Q000032:analysis
D055549:Volatile Organic Compounds; D006046:Gold
Nanoparticle; breath; cancer; sensor; strain; volatile organic compound