Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study.
BACKGROUND
Fibromyalgia is a syndrome characterized by chronic pain, fatigue, depression, and sleep disturbances. Its primary cause is unclear. Several studies have reported decreased intracellular magnesium levels in patients with fibromyalgia and have found negative correlation between magnesium levels and fibromyalgia symptoms.


OBJECTIVE
To gather preliminary data on whether transdermal magnesium can improve quality of life for women who have fibromyalgia.


METHODS
This is a patient questionnaires and survey in a fibromyalgia clinic at a tertiary medical center. Forty female patients with the diagnosis of fibromyalgia were enrolled. Each participant was provided a spray bottle containing a transdermal magnesium chloride solution and asked to apply 4 sprays per limb twice daily for 4 weeks. Participants were asked to complete the Revised Fibromyalgia Impact Questionnaire, SF-36v2 Health Survey, and a quality-of-life analog scale at baseline, week 2, and week 4.


METHODS
Questionnaire and survey scores, evaluated through intent-to-treat and per-protocol analyses.


RESULTS
Twenty-four patients completed the study (mean [SD] age, 57.2 [7.6] years; white, 95%; mean body mass index, 31.3 kg/m2). With intention-to-treat analysis, Revised Fibromyalgia Impact Questionnaire subscale and total scores were significantly improved at week 2 and week 4 (total score, P=0.001). Per-protocol analysis results were similar: all subscales of the Revised Fibromyalgia Impact Questionnaire were significantly improved at week 2 and week 4 (total score, P=0.001).


CONCLUSIONS
This pilot study suggests that transdermal magnesium chloride applied on upper and lower limbs may be beneficial to patients with fibromyalgia.


BACKGROUND
ClinicalTrials.gov.ldentifier NCT01968772.
Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota 55905, USA.
Deborah J
DJ
Engen
Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Samantha J
SJ
McAllister
Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Mary O
MO
Whipple
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota 55905, USA.
Stephen S
SS
Cha
Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Liza J
LJ
Dion
Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Ann
A
Vincent
Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Brent A
BA
Bauer
Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA; E-mail: wahnerroedler.dietlind@mayo.edu.
Dietlind L
DL
Wahner-Roedler
D000279:Administration, Cutaneous; D000368:Aged; D005240:Feasibility Studies; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D015636:Magnesium Chloride / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D010865:Pilot Projects; D011788:Quality of Life
D015636:Magnesium Chloride