Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical space.
Di-, tri- and tetra-substituted oxetane derivatives with combinations of ester, amide, nitrile, aryl, sulfone and phosphonate substituents are prepared as fragments or building blocks for drug discovery. The synthesis of these novel oxetane functional groups, in new chemical space, is achieved via rhodium-catalysed O-H insertion and C-C bond forming cyclisation.
Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK. j.bull@imperial.ac.uk.
Owen A
OA
Davis
Rosemary A
RA
Croft
James A
JA
Bull
D003500:Cyclization; D055808:Drug Discovery; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D004988:Ethers, Cyclic; C005287:oxetane