Low-dose aspirin use does not diminish the immune response to monovalent H1N1 influenza vaccine in older adults.
Non-steroidal anti-inflammatory drugs (NSAIDs) may inhibit antibody production by peripheral blood mononuclear cells; one consequence of this could be decreased effectiveness of vaccines in NSAID users. Because many older adults use low-dose aspirin for primary or secondary prevention of coronary events, any inhibitory effect of aspirin on vaccine immune response could reduce the benefits of vaccination programmes in older adults. We tested whether immune response to vaccination differed between users vs. non-users of low-dose aspirin, using data from four randomized trials of monovalent 2009 pandemic influenza A(H1N1) vaccine. Geometric mean haemagglutination inhibition antibody titres were not significantly lower in low-dose aspirin users compared to non-users. Our results provide reassurance that influenza vaccination effectiveness is probably not reduced in older adults taking chronic low-dose aspirin.
Group Health Research Institute,Seattle,WA,USA.
M L
ML
Jackson
The EMMES Corporation,Rockville MD,USA.
A
A
Bellamy
The EMMES Corporation,Rockville MD,USA.
M
M
Wolff
The EMMES Corporation,Rockville MD,USA.
H
H
Hill
Group Health Research Institute,Seattle,WA,USA.
L A
LA
Jackson
D000368:Aged; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood; D001241:Aspirin / Q000008:administration & dosage / Q000276:immunology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000628:therapy*; D008875:Middle Aged
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D001241:Aspirin
Anti-inflammatory agents; human influenza; non-steroidal; vaccines