Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases.
Applications of polymeric nanotechnologies for enabling therapies for cardiovascular diseases have shown recent success. Both intravenous and oral administration have been investigated and achieved different degrees of development. While circulating polymeric nanostructured carriers are subjected to a number of interactions, smart nanoparticle design has enabled the formulation of active molecules to be delivered to specific targets for cardiovascular effects. This review aims at outlining the multiple factors that can affect the fate of polymeric nanostructured carriers in systemic circulation. With an understanding of these factors, the literature on the various polymeric nanostructured carriers is reviewed. Finally, the emerging uses of nanotechnology to formulate orally administered drugs for cardiovascular diseases are depicted.
Javier O
JO
Morales
Sabrina
S
Sepulveda-Rivas
Felipe
F
Oyarzun-Ampuero
Sergio
S
Lavandero
Santos Dumont 964, Independencia, Santiago 8380494, Chile. mkogan@ciq.uchile.cl.
Marcelo J
MJ
Kogan
D061605:Administration, Intravenous / Q000379:methods; D000284:Administration, Oral; D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D049329:Nanostructures / Q000008:administration & dosage*; D011108:Polymers / Q000008:administration & dosage
D002316:Cardiotonic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers