The analysis of microRNAs miR-200C and miR-145 expression in colorectal cancer of different molecular subtypes.
The expression levels of microRNAs miR-200c and miR-145 in two groups of colorectal cancer differing by the presence/absence of epithelial-mesenchymal transition (EMF) were studied. In the EMF-positive cancer, the level of miR-145 is increased, whereas the level of miR-200c is reduced. The reverse situation is observed in the EMI-negative cancer. MiR-145 can serve as a marker of the mesenchymal subtype of cancer. Gene expression profiles and microRNAs allow prognostically unfavorable tumors of the mesenchymal subtype to be distinguished.
State Scientific Center of Coloproctology, ul. Salyama Adilya 2, Moscow, 123423, Russia.
Y A
YA
Shelygin
V P
VP
Shubin
S A
SA
Frolov
S I
SI
Achkasov
O I
OI
Sushkov
A S
AS
Tsukanov
V N
VN
Kashnikov
N I
NI
Pospekhova
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged
C541010:MIRN145 microRNA, human; C533896:MIRN200 microRNA, human; D035683:MicroRNAs