Sixteen novel C-21 steroidal glycosides from the roots of Cynanchum mooreanum.
Fourteen novel 14,15-diseco-18-nor-pregnane-type steroidal glycosides, mooreanoside A-C (1-3) and mooreanoside F-P (6-16) and two new 14,15-diseco-pregnane-type steroidal glycosides, mooreanoside D-E (4-5) were isolated from the roots of Cynanchum mooreanum Hemsl. Their structures were determined on the basis of spectroscopic and chemical analysis. Compounds 1-6, 8-10, 12-14 and 16 were tested for their immunological activities in vitro against Con-A induced proliferation of mice splenocytes.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Bo
B
Cui
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Xinhong
X
Wang
Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Yifu
Y
Yang
Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Yang
Y
Yang
Institute of Chinese Material Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Songshan
S
Shi
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Fujiang
F
Guo
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Yiming
Y
Li
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D003208:Concanavalin A / Q000037:antagonists & inhibitors / Q000276:immunology; D031105:Cynanchum / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry*; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects* / Q000276:immunology; D013329:Structure-Activity Relationship
D006027:Glycosides; D011278:Pregnanes; C574437:pregnane glycoside; D003208:Concanavalin A
Asclepiadaceae; Cynanchum mooreanum; Immunosuppressive; Steroidal glycosides