Effect of Lactobacillus plantarum on Intestinal Infection in Multiple Drug-Resistant Bacteria Mice.
BACKGROUND
This study aimed to determine the effects of probiotic Lactobacillus plantarum on colitis in mice with multiple drug-resistant bacteria, and to judge the intervention function of probiotics in the resistance of pathogenic bacteria.


METHODS
Male BALB/C mice were divided into four groups. The colonic tissues were collected for pathology observation, permeability, transepithelial electrical resistance (TER), and tight junction protein expression detection at death, and the feces were collected for detecting drug susceptibility of MDR-PA.


RESULTS
MDR-PA mice developed severe intestinal inflammation and tissue damage in which paracellular permeability was increased, in conjunction with decreased expression and redistribution. LP administration attenuated colitis of MDR-PA mice. The drug susceptibility diameter of MDR-PA has increased.


CONCLUSIONS
Probiotics can treat diarrhea of mice by MDR-PA and protect the intestinal barrier function. Probiotics can weaken the resistance of multiple drug resistance in Pseudomonas aeruginosa to some extent.
1 General Surgery, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University , Shanghai, China .
Hua-Zhong
HZ
Han
2 General Surgery, Huadong Hospital , Fudan University, Shanghai, China .
Yi-Jun
YJ
Zhao
3 General Surgery, Shanghai Tenth People's Hospital , Shanghai, China .
Chen-Zhang
CZ
Shi
4 General Surgery, Affiliated First Hospital, Xuzhou Medical College , Xuzhou, China .
Yong
Y
Liang
1 General Surgery, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University , Shanghai, China .
Jun
J
Yang
D000818:Animals; D003092:Colitis / Q000382:microbiology* / Q000473:pathology / Q000628:therapy*; D003106:Colon / Q000473:pathology*; D003967:Diarrhea / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D004195:Disease Models, Animal; D024901:Drug Resistance, Multiple, Bacterial; D041981:Gastrointestinal Tract / Q000382:microbiology*; D048191:Lactiplantibacillus plantarum / Q000254:growth & development*; D008297:Male; D008807:Mice, Inbred BALB C; D019936:Probiotics / Q000008:administration & dosage*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification