Total synthesis of avermectin B1a revisited.
Avermectins were isolated as compounds possessing anthelmintic activity from the culture broth of Streptomycesavermitilis by Ōmura and co-workers. Owing to their potent anthelmintic and insecticidal activities, as well as their unique pentacyclic architecture, the avermectin family attracted keen interest from synthetic organic chemists. We have recently completed a more efficient and straightforward total synthesis of avermectin B1a, as compared with previous syntheses.
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan.
Shuji
S
Yamashita
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan.
Daisuke
D
Hayashi
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan.
Aoi
A
Nakano
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan.
Yujiro
Y
Hayashi
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan.|Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai, Japan.
Masahiro
M
Hirama
D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure
D000871:Anthelmintics; C022120:avermectin B(1)a; D007559:Ivermectin