A novel composite electrode based on tungsten oxide nanoparticles and carbon nanotubes for the electrochemical determination of paracetamol.
An electrochemical sensor was prepared by the modification of a glassy carbon electrode (GCE) with a composite of nanoparticles of tungsten oxide (WO3) and carbon nanotubes (CNTs) for the quantification of paracetamol (PR). Energy dispersive X-ray analysis (EDX) and scanning electron microscopy (SEM) were performed for the characterization of the nanocomposite layer. Compared with a bare GCE and a GCE modified with CNTs, the proposed electrode (WO3NPs/CNTs/GCE) exhibited a well-defined redox couple for PR and a marked enhancement of the current response. The experimental results also showed that ascorbic acid (AA) did not interfere with the selective determination of PR. The proposed electrode was used for the determination of PR in 0.1M phosphate buffer solution (PBS) at pH7.0 using square wave voltammetry (SWV). The peak current increased linearly with the concentration of PR in the range of 1.0×10(-9)-2.0×10(-7)M. The detection limit (LOD) was 5.54×10(-11)M (based on 3Sb/m). The proposed voltammetric sensor provided long-time stability, improved voltammetric behavior and good reproducibility for PR. The selective, accurate and precise determination of PR makes the proposed electrode of great interest for monitoring its therapeutic use.
Department of Chemistry, Harran University, Şanlıurfa 63510, Turkey.
Aysegul Kutluay
AK
Baytak
Department of Chemistry, Harran University, Şanlıurfa 63510, Turkey.
Sehriban
S
Duzmen
Department of Chemistry, Harran University, Şanlıurfa 63510, Turkey.
Tugce
T
Teker
Department of Chemistry, Harran University, Şanlıurfa 63510, Turkey. Electronic address: maslanoglu@harran.edu.tr.
Mehmet
M
Aslanoglu
D000082:Acetaminophen / Q000032:analysis*; D018712:Analgesics, Non-Narcotic / Q000032:analysis; D003217:Conductometry / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014414:Tungsten / Q000737:chemistry*
D018712:Analgesics, Non-Narcotic; D037742:Nanotubes, Carbon; D010087:Oxides; D000082:Acetaminophen; C511604:tungsten oxide; D014414:Tungsten
Carbon nanotubes; Materials; Paracetamol; Sensor; Tungsten oxide nanoparticles