T-CELL LYMPHOCYTIC LEUKEMIA IN A FALLOW DEER (DAMA DAMA).
A 17-yr-old female fallow deer presented with ataxia, inappetence, decreased fecal output, and decreased mentation. A complete blood count demonstrated leukocytosis (24.1×10(3)/μl, n=1.16-7.38×10(3)/μl), characterized by lymphocytosis (22.89×10(3)/μl, n=0.18-3.65×10(3)/μl), anemia (packed cell volume 20%, n=29.0-55.8%), decreased red blood cell count (4.1×10(3)/μl, n=6.86-14.72×10(3)/μl), and decreased hemoglobin (7.5 g/dl, n=9.4-19.2 g/dl). Numerous mature, well-differentiated lymphocytes were noted on the blood film. Despite treatment and clinical improvement, the decision was made to euthanize the deer. Histopathology identified a monomorphic population of CD3 positive, CD79a negative small lymphocytes replacing most of the hematopoietic tissue in the bone marrow without evidence of tissue invasion. Results of viral screening were negative.
Wm Kirk
WK
Suedmeyer
Brian G
BG
Stockinger
Michael M
MM
Garner
Daniel S
DS
Bradway
Charlotte
C
Hollinger
Matti
M
Kiupel
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003670:Deer; D003907:Dexamethasone / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy; D007792:Lactulose / Q000627:therapeutic use; D015458:Leukemia, T-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D010402:Penicillin G Procaine / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D010402:Penicillin G Procaine; C004180:dexamethasone 21-phosphate; D007792:Lactulose; D003907:Dexamethasone
Epizootic hemorrhagic disease virus; T lymphocytes; bovine leucosis virus; fallow deer (Dama dama); lymphocytic leukemia