The Possible Link between GABAergic Dysfunction and Cognitive Decline in a Patient with Idiopathic Hypoparathyroidism.
Idiopathic hypoparathyroidism (IHP) is accompanied by cognitive impairment. We report the case of a 70-year-old IHP patient with cognitive disturbance. Brain computed tomography showed bilateral calcification in basal ganglia, thalamus, and cerebellum. Neuropsychological assessment revealed low scores for intelligence, memory, and perseverative errors. Brain positron emission tomography showed a significant reduction in [(18)F]-Fludeoxyglucose (FDG) uptake in bilateral frontal, left temporal and parietal cortices, along with a marked reduction in [(11)C]-flumazenil binding in left frontal, temporal, parietal, and bilateral cerebellum. These findings suggest cognitive impairment in IHP may be ascribed to GABAergic dysfunction, thus leading to, or coexisting with, cerebral hypometabolism.
Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, Japan.
Tatsuhiro
T
Terada
Akihiro
A
Kakimoto
Etsuji
E
Yoshikawa
Satoshi
S
Kono
Tomoyasu
T
Bunai
Yasushi
Y
Hosoi
Makiko
M
Sakao-Suzuki
Takashi
T
Konishi
Hiroaki
H
Miyajima
Yasuomi
Y
Ouchi
D000368:Aged; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D002114:Calcinosis / Q000000981:diagnostic imaging; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D006801:Humans; D007011:Hypoparathyroidism / Q000150:complications / Q000378:metabolism* / Q000473:pathology* / Q000523:psychology; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D018080:Receptors, GABA-B / Q000378:metabolism*; D013788:Thalamus / Q000473:pathology; D014057:Tomography, X-Ray Computed; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D019275:Radiopharmaceuticals; D018080:Receptors, GABA-B; D019788:Fluorodeoxyglucose F18; D005680:gamma-Aminobutyric Acid