Choroidal maps in non-exudative age-related macular degeneration.
OBJECTIVE
To compare choroidal thickness maps (CMs) in patients with non-exudative age-related macular degeneration (AMD) and control subjects using swept source optical coherence tomography (Swept-OCT).


METHODS
CMs were automatically measured in the different Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors in eyes with early non-exudative AMD (early AMD) (large soft drusen: group 1; reticular pseudodrusen: group 2 and variable combination of large soft drusen and reticular pseudodrusen: group 3), late non-exudative AMD/geographic atrophy (GA) (late AMD) (group 4) and control subjects (group 5). Fundus autofluorescence (FAF) images were overlaid to sectorial CMs in late-AMD group (group 4).


RESULTS
A total of 90 eyes (90 patients, 79.7±8.34 years old) were included. CMs were significantly reduced in early-AMD group 2 and 3 and late-AMD group 4 compared with control subjects in group 5 and early-AMD group 1 (large soft drusen alone) for each ETDRS sectors (p<0.05). No difference in CMs was found by comparing group 2 with 3 and group 2 and 3 with group 4. No statistical differences in CMs were found among ETDRS sectors with >50% absence of FAF ('Hypo FAF' sectors) resulting from retinal atrophy versus ≤50% absence of FAF ('hyper/iso FAF' sectors owing to >50% preserved retina) in late-AMD group (group 4) (p=0.328).


CONCLUSIONS
CMs appeared thinner in early non-exudative AMD with intermediate distribution of reticular pseudodrusen versus control subjects and early non-exudative AMD with drusen alone. Same results were found in the group with variable combination of large soft drusen and reticular pseudodrusen. In GA eyes, a choroidal thinning could be detected independently of the retinal pigmented epithelium status.
Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France.
Vittorio
V
Capuano
Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France Groupe de Recherche Clinique Macula, Universite Paris Est, Creteil, France.
Eric H
EH
Souied
Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France.
Alexandra
A
Miere
Groupe de Recherche Clinique Macula, Universite Paris Est, Creteil, France Centre de Ressources Biologiques et Centre de Recherche Clinique du Centre Hopitalier Intercommunal de Créteil, Creteil, France.
Camille
C
Jung
Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France.
Eliana
E
Costanzo
Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France Groupe de Recherche Clinique Macula, Universite Paris Est, Creteil, France.
Giuseppe
G
Querques
D000368:Aged; D000369:Aged, 80 and over; D058452:Axial Length, Eye; D002829:Choroid / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D057092:Geographic Atrophy / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012029:Refraction, Ocular / Q000502:physiology; D015593:Retinal Drusen / Q000175:diagnosis; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
Degeneration; Imaging; Retina