Human papillomavirus infection in the oromaxillofacial area: Clinical anatomy and histological considerations.
Clinical manifestations of human papillomavirus (HPV) infection in the head and neck can range from benign lesions, which are the most frequent, to malignant lesions. The prevalence of head and neck cancer is increasing, despite currently decreasing trends in known risk factors such as smoking and alcohol use. A new patient profile has appeared in recent practice: most frequently a middle-aged male patient who does not smoke or drink alcohol, is sexually active (possibly having multiple partners), and presents with oral or cervicofacial lesions requiring diagnosis and treatment. Another risk factor that should be considered in these patients is HPV infection. The association of oral potentially malignant disorders (OPMD) with HPV is a challenge for the medical practitioner. The gold standard for diagnosis is histopathological examination, which can also yield evidence suggesting HPV infection. Determination of the viral genotype provides additional data for assessing the oncological risk of an HPV infection. Treatment of these patients is aimed at removing the lesions, in association or not with antiviral treatment and recurrence control.
Department of Oral Rehabilitation, Oral Health and Dental Office Management, "Iuliu Haţieganu" University of Medicine and Pharmacy, Oral Health and Dental Office Management, Faculty of Dentistry, Cluj-Napoca, Romania.
Aranka
A
Ilea
Department of Histology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Faculty of Medicine, Cluj-Napoca, Romania.
Bianca
B
Boşca
Department of Histology and Embryology, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Cluj-Napoca.
Viorel
V
MiclĂuş
Department of Histology and Embryology, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Cluj-Napoca.
Vasile
V
Rus
Department of Oral and Maxillofacial Surgery, Clinical County Hospital Cluj-Napoca, "Iuliu Haṭieganu" University of Medicine and Pharmacy, Faculty of Dentistry, Cluj-Napoca, Romania.
Anida Maria
AM
BĂbţan
Department of Oral Rehabilitation, Oral Health and Dental Office Management, "Iuliu Haţieganu" University of Medicine and Pharmacy, Oral Health and Dental Office Management, Faculty of Dentistry, Cluj-Napoca, Romania.
Radu Septimiu
RS
CÂmpian
D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000821:virology; D006801:Humans; D007818:Laryngeal Diseases / Q000473:pathology / Q000821:virology*; D009059:Mouth Diseases / Q000473:pathology / Q000821:virology*; D027383:Papillomaviridae / Q000502:physiology*; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012307:Risk Factors
head and neck; human papillomavirus; infection; koilocytosis; squamous cell carcinoma