From paramutation to human disease: RNA-mediated heredity.
Epigenetic variation, a stable alteration in gene expression, occurs at multiple moments during development. Several instances of non-Mendelian transmission to the progenies modes are very intriguing. Studies of the mode of hereditary transmission revealed in a series of such cases a role of noncoding RNA molecules as inducers. While still an enigmatic mechanism, emerging models pinpoint to a more general roles of these variations, initiated as a response to genetic and environmental variation. Here we compare the known modes of transgenerational epigenetic variation in mice and humans.
Université de Nice Sophia Antipolis, Inserm U1091 - CNRS U7277, 06034 Nice, France. Electronic address: minoo@unice.fr.
Minoo
M
Rassoulzadegan
Université de Nice Sophia Antipolis, Inserm U1091 - CNRS U7277, 06034 Nice, France.
François
F
Cuzin
D000818:Animals; D004194:Disease / Q000235:genetics*; D044127:Epigenesis, Genetic; D040941:Heredity; D006801:Humans; D009154:Mutation; D022661:RNA, Untranslated / Q000235:genetics*
D022661:RNA, Untranslated
Epigenetic; Heredity; Noncoding RNA; Paramutation; Sperm