Plasma markers of endothelial dysfunction in patients with hypertensive disorders of pregnancy: a pilot study in a South Indian population.
OBJECTIVE
To assess the plasma markers of endothelial dysfunction: VonWillebrand factor (vWF), Platelet derived microparticles (PMPs), and Endothelin-1 (ET-1) in various types of hypertensive disorders of pregnancy and correlate with the pregnancy outcome.


METHODS
Plasma levels of vWF, PMPs and ET-1 were analyzed by ELISA kits in gestational hypertension (GH), late onset preeclampsia (LOPE), early onset preeclampsia (EOPE), eclampsia (E) and control pregnant women (CPW) during third trimester. The gestational age at the time of delivery (GA) and birthweight (BW) of the baby also were measured.


RESULTS
The GA and the BW of the baby were found to be significantly lower in EOPE and eclampsia compared to CPW, GH and LOPE. The circulating levels of markers of endothelial dysfunction: vWF, PMPs and ET-1 were significantly higher in EOPE and Eclampsia compared to CPW, GH. Also a negative correlation was observed between vWF levels with pregnancy outcome; GA and BW.


CONCLUSIONS
A generalized endothelial dysfunction and poor birth outcomes were observed in hypertensive disorders of pregnancy. There is a spectrum of biochemical derangements related to endothelial dysfunction in GH, EOPE, LOPE and E in that order.
a Department of Biochemistry .
Vickneshwaran
V
Vinayagam
a Department of Biochemistry .
Zachariah
Z
Bobby
b Department of Obstetrics and Gynaecology , and.
Syed
S
Habeebullah
b Department of Obstetrics and Gynaecology , and.
Latha
L
Chaturvedula
c Department of Neonatology , Jawaharlal Institute of Postgraduate Medical Education and Research , Puducherry , India.
S K
SK
Bharadwaj
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001724:Birth Weight; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000503:physiopathology; D007194:India; D007231:Infant, Newborn; D010865:Pilot Projects; D011247:Pregnancy; D011256:Pregnancy Outcome; D014652:Vascular Diseases / Q000097:blood* / Q000503:physiopathology; D055815:Young Adult
D015415:Biomarkers
Endothelial dysfunction; hypertensive disorders of pregnancy; pregnancy outcome