Age- and bite-structured models for vector-borne diseases.
The biology and behaviour of biting insects is a vitally important aspect in the spread of vector-borne diseases. This paper aims to determine, through the use of mathematical models, what effect incorporating vector senescence and realistic feeding patterns has on disease. A novel model is developed to enable the effects of age- and bite-structure to be examined in detail. This original PDE framework extends previous age-structured models into a further dimension to give a new insight into the role of vector biting and its interaction with vector mortality and spread of disease. Through the PDE model, the roles of the vector death and bite rates are examined in a way which is impossible under the traditional ODE formulation. It is demonstrated that incorporating more realistic functions for vector biting and mortality in a model may give rise to different dynamics than those seen under a more simple ODE formulation. The numerical results indicate that the efficacy of control methods that increase vector mortality may not be as great as predicted under a standard host-vector model, whereas other controls including treatment of humans may be more effective than previously thought.
Warwick Mathematics Institute, Zeeman Building, University of Warwick, Coventry CV4 7AL, United Kingdom; WIDER Centre, University of Warwick, Coventry CV4 7AL, United Kingdom. Electronic address: k.s.rock@warwick.ac.uk.
K S
KS
Rock
Warwick Mathematics Institute, Zeeman Building, University of Warwick, Coventry CV4 7AL, United Kingdom.
D A
DA
Wood
Warwick Mathematics Institute, Zeeman Building, University of Warwick, Coventry CV4 7AL, United Kingdom; WIDER Centre, University of Warwick, Coventry CV4 7AL, United Kingdom.
M J
MJ
Keeling
D000367:Age Factors; D000818:Animals; D001733:Bites and Stings; D005247:Feeding Behavior / Q000502:physiology; D006801:Humans; D007303:Insect Vectors / Q000502:physiology*; D008136:Longevity; D008954:Models, Biological; D008962:Models, Theoretical
Feeding patterns; PDE model; Structured population model; Vector behaviour; Vector-borne disease