Pertussis in the Era of New Strains of Bordetella pertussis.
Despite implementation of a successful vaccination program, pertussis remains a significant health problem. Although the incidence of pertussis in the United States is reduced by approximately 80% compared with incidence before the introduction of vaccination in the 1940s, deaths still occur and the unrecognized disease burden remains high, with 1 million Bordetella pertussis infections annually in the United States estimated by serologic surveys. Reasons for the resurgence and current prevalence of pertussis may be multifactorial and include waning vaccine-induced protection as well as lower vaccine effectiveness, failure to vaccinate, and changes in the organism itself.
Section of Infectious Diseases, Department of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, 160 East Erie Avenue, Philadelphia, PA 19134, USA. Electronic address: Emily.souder@drexelmed.edu.
Emily
E
Souder
Section of Infectious Diseases, Department of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, 160 East Erie Avenue, Philadelphia, PA 19134, USA.
Sarah S
SS
Long
D000293:Adolescent; D001886:Bordetella pertussis / Q000145:classification* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology; D011247:Pregnancy; D015995:Prevalence; D014481:United States / Q000453:epidemiology; D014611:Vaccination; D014917:Whooping Cough / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D055815:Young Adult
D010567:Pertussis Vaccine
Acellular vaccine; Bordetella pertussis; Strain adaptation; Waning immunity; Whole-cell vaccine