Metabolic syndrome increases oxidative stress but does not influence disability and short-time outcome in acute ischemic stroke patients.
Oxidative stress has been implicated in the pathophysiology of cardiovascular disease and MetS and it may be one of molecular mechanisms involved in stroke. The aims of the present study were to verify differences in oxidative stress markers in acute ischemic stroke patients with and without MetS and to verify whether MetS influences disability and short time outcome of the patients. 148 patients with acute ischemic stroke were divided in two groups: with MetS (n = 92) and without MetS (n = 56). The modified Rankin Scale (mRS) was used for measuring the functional disability after 3-month follow-up. The study assessed the metabolic profile and oxidative stress markers. Stroke patients with MetS had higher levels of lipid hydroperoxides (p < 0.0001) and advanced oxidation protein products (AOPP, p = 0.0302) than those without MetS. Hydroperoxides were directly and independently associated with MetS (OR: 1.000, 95 % IC = 1.000-1.000, p = 0.005). Linear regression demonstrated that AOPP levels (R(2) = 0.281, p < 0.0001) and oxidative stress index (OSI, R(2) = 0.223, p < 0.0001) were directly associated with triglycerides levels and hydroperoxides levels was also directly associated with glucose levels (R(2) = 0.080, p = 0.013. The mRS and short-come outcome did not differ after 3 months in both groups. In conclusion, an increase in oxidative stress markers was shown in acute ischemic stroke patients with MetS and this elevation seems to be involved mainly with changes in lipid profile, but the presence of MetS did not influence short-time disability and survival of the acute ischemic stroke patients.
Department Clinical of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Robert Koch Avenue n° 60 Bairro Cervejaria, Londrina, Paraná, 86038-440, Brazil. deianame@yahoo.com.br.
Andrea Name Colado
AN
Simão
Department of Neurological Surgery, University of Londrina, Londrina, Paraná, Brazil.
Marcio Francisco
MF
Lehmann
Department Clinical of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Robert Koch Avenue n° 60 Bairro Cervejaria, Londrina, Paraná, 86038-440, Brazil.
Daniela Frizon
DF
Alfieri
Department Clinical of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Robert Koch Avenue n° 60 Bairro Cervejaria, Londrina, Paraná, 86038-440, Brazil.
Milena Zardetto
MZ
Meloni
Department Clinical of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Robert Koch Avenue n° 60 Bairro Cervejaria, Londrina, Paraná, 86038-440, Brazil.
Tamires
T
Flauzino
Department Clinical of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Robert Koch Avenue n° 60 Bairro Cervejaria, Londrina, Paraná, 86038-440, Brazil.
Bruna Miglioranza
BM
Scavuzzi
Department of Clinical Analysis, University North of Paraná (UNOPAR), Londrina, Paraná, Brazil.
Sayonara Rangel
SR
de Oliveira
Department Clinical of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Robert Koch Avenue n° 60 Bairro Cervejaria, Londrina, Paraná, 86038-440, Brazil.
Marcell Alysson Batisti
MA
Lozovoy
Department of Internal Medicine, University of Londrina, Londrina, Paraná, Brazil.
Isaias
I
Dichi
Department Clinical of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Robert Koch Avenue n° 60 Bairro Cervejaria, Londrina, Paraná, 86038-440, Brazil.
Edna Maria Vissoci
EM
Reiche
D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism*; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D020521:Stroke / Q000209:etiology / Q000503:physiopathology*; D016019:Survival Analysis; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D014280:Triglycerides; D006861:Hydrogen Peroxide
Disability; Metabolic syndrome; Modified Rankin scale; Oxidative stress; Stroke