CLINICAL AND ANAMNESTIC CHARACTERISTICS OF DEVELOPMENT OF ANTISPERM IMMUNITY IN INFERTILE MEN.
The aim of the research was to establish connection between the roles of infertility duration, patient age, various extragenital and genital pathologies in ASA pathogenesis. The work is based on retrospective analysis of 496 outpatient cards, which covered detailed anamnestic data and results of past complex clinico-laboratory tests. Criteria for inclusion in the study was infertility during marriage for at least 18 month, high concentration of ASA-s in booth blood and sperm. It was found that there is no statistically significant connection between the ASA and past illnesses, profession, family history, accompanying autoimmune diseases and extragenital pathologies. Chlamydia trachomatis, Ureaplasma urealyticum, and Mycoplasma hominis compared to other STDs, cause statistically significant increase of ASAs concentration in blood serum, as well as in ejaculate (p<0,001). Testicle associated pathologies plays an important role in development of antisperm immunity, especially orchitis and epididymitis, during which statistically insignificant increase of levels of ASA has been detected in blood, as well as in semen (p<0,001). Thus, we can conclude that, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, orchitis and epididymitis causes malfunction of blood-testicular barrier, which resulted in inflammatory and toxic damage of spermatogenic epithelium, which in turn plays significant role in the development of autoimmune infertility.
D. Tvildiani Medical University, Tbilisi; I. Javakhishvili Tbilisi State University, Medical Faculty; National Centre of Dermatology and Venerology, Tbilisi, Georgia.
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Tchiokadze
D. Tvildiani Medical University, Tbilisi; I. Javakhishvili Tbilisi State University, Medical Faculty; National Centre of Dermatology and Venerology, Tbilisi, Georgia.
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Galdava
D000328:Adult; D000906:Antibodies / Q000097:blood / Q000276:immunology*; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000472:pathogenicity; D004823:Epididymitis / Q000150:complications / Q000276:immunology; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D008297:Male; D019535:Mycoplasma hominis / Q000472:pathogenicity; D009920:Orchitis / Q000150:complications / Q000276:immunology; D012661:Semen / Q000276:immunology; D012749:Sexually Transmitted Diseases / Q000150:complications / Q000276:immunology; D013094:Spermatozoa / Q000276:immunology* / Q000473:pathology; D016990:Ureaplasma urealyticum / Q000472:pathogenicity
D000906:Antibodies