Promise of cancer stem cell vaccine.
Dendritic cell (DC)-based vaccines designed to target cancer stem cells (CSC) can induce significant antitumor responses via conferring host anti-CSC immunity. Our recent studies have demonstrated that CSC-DC vaccine could inhibit metastasis of primary tumors and induce humoral immune responses against cancer stem cells. This approach highlights the promise of cancer stem cell vaccine in cancer immunotherapy.
a Comprehensive Cancer Center; University of Michigan ; Ann Arbor , MI USA.|b Department of Biotherapy ; Tianjin University Cancer Institute and Hospital; National Clinical Research Center of Cancer; Key Laboratory of Cancer Immunology and Biotherapy ; Tianjin , China.
Li
L
Zhou
a Comprehensive Cancer Center; University of Michigan ; Ann Arbor , MI USA.|c State Key Laboratory of Oncology in Southern China and Department of Experimental Research ; Sun Yat-sen University Cancer Center ; Guangzhou , China.|d Present affiliation: Department of Medical Oncology ; Guangzhou First People's Hospital; Guangzhou Medical University ; Guangzhou , China.
Lin
L
Lu
a Comprehensive Cancer Center; University of Michigan ; Ann Arbor , MI USA.
Max S
MS
Wicha
a Comprehensive Cancer Center; University of Michigan ; Ann Arbor , MI USA.
Alfred E
AE
Chang
c State Key Laboratory of Oncology in Southern China and Department of Experimental Research ; Sun Yat-sen University Cancer Center ; Guangzhou , China.
Jian-chuan
JC
Xia
b Department of Biotherapy ; Tianjin University Cancer Institute and Hospital; National Clinical Research Center of Cancer; Key Laboratory of Cancer Immunology and Biotherapy ; Tianjin , China.
Xiubao
X
Ren
a Comprehensive Cancer Center; University of Michigan ; Ann Arbor , MI USA.
Qiao
Q
Li
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000627:therapeutic use*; D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D051379:Mice; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009369:Neoplasms / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000276:immunology*
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines
cancer stem cell (CSC); dendritic cells (DC); programmed death-1 (PD-1); vaccine