Atopic allergy and chronic inflammation of the oral mucosa in a 3-year-old boy after heart transplantation - diagnostic and therapeutic difficulties.
In recent years, we have been observing an increased proportion of atopic diseases in children after solid organ transplantation. The pathogenesis of post-transplantation allergy is not completely understood and probably involves several factors, including immunosuppressive therapy. In this paper we present a case of 3-year old boy, after orthotopic heart transplantation at 6 months of age, with symptoms of food allergy associated with atopic dermatitis and changes in the orofacial area. The mentioned symptoms and elevated levels of total and specific IgE occurred with a year of transplant. Because of failure to achieve remission after typical allergy therapy we suspected that the reason of allergy in this case can be immunosuppressive therapy.
Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Independent Public Clinical Hospital No. 1 in Zabrze, Poland.
Edyta
E
Machura
Department of Cardiology, Congenital Heart Diseases, and Electrotherapy with the Division of Pediatric Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze, Poland.
Beata
B
Chodór
Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Independent Public Clinical Hospital No. 1 in Zabrze, Poland.
Magdalena
M
Kleszyk
Department and Clinic of Internal Medicine, Dermatology, and Allergology in Zabrze, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Poland.
Małgorzata
M
Pindycka-Piaszczyńska
Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Independent Public Clinical Hospital No. 1 in Zabrze, Poland.
Ewelina
E
Chrobak
Department of Cardiology, Congenital Heart Diseases, and Electrotherapy with the Division of Pediatric Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze, Poland.
Jacek
J
Białkowski
atopic dermatitis; children; heart transplantation; post-transplantation allergy; tacrolimus