NS1: A corner piece in the dengue pathogenesis puzzle?
Soluble dengue virus NS1 protein induces proinflammatory immune responses via Toll-like receptor 4 and disrupts endothelial cell integrity, resulting in vascular leakage (Beatty et al. and Modhiran et al., this issue).
Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. stephen.j.thomas3.mil@mail.mil.
Stephen J
SJ
Thomas
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003716:Dengue Virus / Q000378:metabolism*; D042783:Endothelial Cells / Q000473:pathology*; D006801:Humans; D051197:Toll-Like Receptor 4 / Q000378:metabolism*; D014611:Vaccination; D017361:Viral Nonstructural Proteins / Q000276:immunology*
D051197:Toll-Like Receptor 4; D017361:Viral Nonstructural Proteins