Association of functional genetic variants in PPARδ encoding peroxisome proliferator-activated receptor delta with ischemic stroke in Chinese Uyghur population.
PPARδ belongs to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. Through these effects, they might be involved with the ischemic stroke (IS). We recruited 200 subjects (100 IS patients diagnosed by CTs or/and magnetic resonance imaging (MRI) and 100 normal healthy controls from Chinese Uyghur population) to assess the nature of the functional polymorphisms of PPARδ +294T/C and any links with IS in this unique population. We found that the C allele of the PPARδ +294T/C polymorphism was more common in controls than IS subjects in the Uyghur population. C allele carriage may be associated with an increased risk of IS in Uyghurs with a strong trend (OR 1.79, 95% CI: 1.11-2.89). Additionally, the PPARδ CC and TC genotypes were less frequent in Uyghur population than in Han population. Our population and ethnic-based study demonstrates that the PPARδ +294C allele maybe an independent risk of IS in Chinese Uyghurs especially in the male (OR 1.99, 95%CI:1.06-3.72) and obesity populations (OR 2.36, 95%CI: 1.19-4.67), which were consistent with Tunisian Population. Moreover, total cholesterol, fasting blood glucose, waist-to-hip ratio, hypertension, history of heart diseases, and negative events may increase the risk of IS, with a trend for HDL to be a protective factor for IS in the Uyghur population. However, larger populations are warranted to validate our findings.
Hubei Center for Disease Control and Prevention, Wuhan 430079, PR China; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China; Key Laboratory of Molecular Biology of Guangdong province, Shenzhen Center for Disease Controls and Prevention, Shenzhen, 518020, PR China.
Yeqing
Y
Tong
Hubei Center for Disease Control and Prevention, Wuhan 430079, PR China.
Faxian
F
Zhan
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China; Wuhan Center for Disease Control and Prevention, Wuhan 430015, PR China.
Li
L
Cai
Hubei Center for Disease Control and Prevention, Wuhan 430079, PR China.
ShengHong
S
Han
Hubei Center for Disease Control and Prevention, Wuhan 430079, PR China.
Xuhuan
X
Guan
Key Laboratory of Molecular Biology of Guangdong province, Shenzhen Center for Disease Controls and Prevention, Shenzhen, 518020, PR China.
Liangqiang
L
Lin
Department of Epidemiology and Statistics, School of Public Health, Mudanjiang Medical College, Heilongjiang 157011, PR China.
Xiaoxia
X
Li
Hubei Center for Disease Control and Prevention, Wuhan 430079, PR China.
Shuangyi
S
Hou
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: qi_weiliao@126.com.
Qing
Q
Lu
Hubei Center for Disease Control and Prevention, Wuhan 430079, PR China. Electronic address: l_jiafa@163.com.
Jiafa
J
Liu
D000368:Aged; D002545:Brain Ischemia / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology / Q000235:genetics*; D047494:PPAR delta / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors; D020521:Stroke / Q000208:ethnology / Q000235:genetics*
D047494:PPAR delta
Case–control study; Functional polymorphisms; Ischemic stroke; Odds ratio; Peroxisome proliferator-activated receptor Delta; Uyghur population