Biomarker-based MicroRNA Therapeutic Strategies for Hepatocellular Carcinoma.
Recently, microRNAs (miRNAs) have emerged as key factors involved in a series of biological processes, ranging from embryogenesis to programmed cell death. Its link to aberrant expression profiles has rendered it a potentially attractive tool for the diagnosis, prognosis, or treatment of various diseases. Accumulating evidence has indicated that miRNAs act as tumor suppressors in hepatocyte malignant transformation by regulating development, differentiation, proliferation, and tumorigenesis. Here, we summarize recent progress in the development of novel biomarker-based miRNA therapeutic strategies for hepatocellular carcinoma (HCC).
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China ; Department of Immunology, Medical School of Nantong University, Nantong, Jiangsu, China.
Min
M
Yao
Department of Medical Informatics, Medical School of Nantong University, Nantong, Jiangsu, China.
Li
L
Wang
The Hospital of Nantong Maternal and Child Care Service, Nantong, Jiangsu, China.
Yao
Y
Yao
The Hospital of Nantong Maternal and Child Care Service, Nantong, Jiangsu, China.
Hong-Bing
HB
Gu
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Deng-Fu
DF
Yao
Hepatocellular carcinoma; MicroRNA; Molecular target; Therapy