Predictors of intensive care unit length of stay and intracranial pressure in severe traumatic brain injury.
OBJECTIVE
The aim of this study was to explore the relationship of intracranial pressure (ICP) with intensive care unit (ICU) length of stay in a large cohort of severe traumatic brain injury patients and identify factors associating with prolonged ICU course.


METHODS
This was a single-center database review of de-identified research data that had been prospectively collected; setting: neurosurgical ICU, Ben Taub General Hospital, Houston, TX.


RESULTS
In a cohort of 438 severe traumatic brain injury (TBI) patients, 149 (34%) had a motor Glasgow Coma Scale score of 1 to 3 on admission and 284 (65%) had 4 to 5. Intracranial pressure during the ICU course was 19.8±11.2 mm Hg. Favorable outcome was obtained in 148 (34%), and unfavorable, in 211 (48%) patients with a mortality of 28%. ICU length of stay (LOS) was 19.4±13.9 days. Joint modeling of ICP and ICU LOS was undertaken, adjusted for the International Mission for Prognosis and Analysis of Clinical Trials in TBI admission prognostic indicators. A higher ICP was not significantly associated with longer ICU LOS (P=.4). However, presence of a mass lesion on admission head computed tomography was strongly correlated with a prolonged ICU LOS (P=.0007). Diffuse injuries with basal cistern compression or midline shift were marginally associated with a longer ICU LOS (P=.053).


CONCLUSIONS
ICP, as monitored and managed according to BTF guidelines, is not associated with ICU length of stay. Patients with severe TBI and a mass lesion on admission head computed tomography were found to have prolonged ICU LOS independently of other indicators of injury severity and intracranial pressure course.
Division of Neurocritical Care, Department of Neurology, Baylor College of Medicine, Houston, TX. Electronic address: lazaridi@bcm.edu.
Christos
C
Lazaridis
Division of Biostatistics, School of Public Health, University of Texas, Houston, TX.
Ming
M
Yang
Division of Biostatistics, School of Public Health, University of Texas, Houston, TX.
Stacia M
SM
DeSantis
Division of Biostatistics, School of Public Health, University of Texas, Houston, TX.
Sheng T
ST
Luo
Department of Neurosurgery, Baylor College of Medicine, Houston, TX.
Claudia S
CS
Robertson
D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D007427:Intracranial Pressure / Q000502:physiology*; D007902:Length of Stay / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013781:Texas; D014057:Tomography, X-Ray Computed; D055815:Young Adult
Computed tomography; Intensive care unit; Intracranial pressure; Length of stay; Mass lesions; Traumatic brain injury