A hypoxic ticket to the bone metastatic niche.
Hypoxia is a well-characterized driver of aggressive cancer phenotypes, including metastasis. Accumulating evidence suggests that, in addition to having local effects, the consequences of tumour hypoxia can be systemic, leading to the formation of pre-metastatic niches that can later foster metastatic colonization in distant organs. Recent findings have demonstrated that such niches can also form in the bone, possibly revealing new avenues for therapeutic intervention.
MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, CB2 0XZ, UK. sv358@mrc-cu.cam.ac.uk.
Sakari
S
Vanharanta
D001859:Bone Neoplasms / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology; D015687:Cell Hypoxia / Q000502:physiology*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D059016:Tumor Microenvironment / Q000502:physiology