Basal Ganglia Perfusion in Fibromyalgia is Related to Pain Disability and Disease Impact: An Arterial Spin Labeling Study.
Pain disability is a major impediment to fibromyalgia (FM) patients' quality of life. Neuroimaging studies have demonstrated abnormal pain processing in FM. However, it is not known whether there are brain abnormalities linked to pain disability. Understanding neural correlates of pain disability in FM, independent from pain intensity, could provide a framework to guide future more efficient therapy strategies to improve patients' functional ability.



We used arterial spin labeling to image cerebral blood flow (CBF) in 23 FM patients and 16 controls. Functional connectivity was also estimated using blood oxygenation level-dependent imaging to further investigate the possible underpinnings of the observed CBF changes.



Among patients, CBF in the basal ganglia correlated negatively with pain disability index and positively with the overall impact of FM (Fibromyalgia Impact Questionnaire) but did not correlate with pain intensity. Whole-brain analysis revealed no CBF differences between the 2 groups; however, post hoc analysis in the basal ganglia showed CBF reductions mainly in the right putamen and right lateral globus pallidus in patients, likely reflecting the negative correlation with the pain disability index. However, the connectivity of the corresponding corticobasal ganglia-thalamus loop, that is, motor network (the connection between supplementary motor area, putamen, and thalamus) remained intact.



Basal ganglia perfusion reflects long-term symptoms, including somatic and psychological components of FM rather than pain intensity. These CBF findings may reflect differences in behavioral and psychological responses between patients.
*Lawson Health Research Institute, St. Joseph's Health Care London Departments of †Medical Biophysics ∥Clinical Neurosciences and Oncology ¶Anesthesia and Perioperative Medicine #Psychology, The University of Western Ontario, London ‡Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute §Department of Surgery and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Mahsa
M
Shokouhi
Karen D
KD
Davis
Dwight E
DE
Moulin
Pat
P
Morley-Forster
Warren R
WR
Nielson
Yves
Y
Bureau
Keith
K
St Lawrence
D000328:Adult; D000344:Afferent Pathways / Q000098:blood supply / Q000000981:diagnostic imaging; D001479:Basal Ganglia / Q000098:blood supply* / Q000000981:diagnostic imaging*; D005260:Female; D005356:Fibromyalgia / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology*; D010147:Pain Measurement; D055420:Perfusion Imaging; D011788:Quality of Life; D012044:Regression Analysis; D013113:Spin Labels
D013113:Spin Labels