RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis.
Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan.|Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Hideaki
H
Kakeya
Chemical Genetics Laboratory, RIKEN, Saitama, Japan.|Frontier Research Core for Life Sciences, University of Toyama, Toyama, Japan.
Daisuke
D
Kaida
Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
Hiromi
H
Sekiya
Fermentation Research Division, Astellas Research Technologies Co. Ltd., Ibaraki, Japan.
Koji
K
Nagai
Chemical Genetics Laboratory, RIKEN, Saitama, Japan.
Minoru
M
Yoshida
Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
Hiroyuki
H
Osada
D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000494:pharmacology*; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010750:Phosphoproteins / Q000037:antagonists & inhibitors*; D011714:Pyrans / Q000494:pharmacology*; D000072260:RNA Splicing Factors; D017413:Ribonucleoprotein, U2 Small Nuclear / Q000037:antagonists & inhibitors*; D017381:Spliceosomes / Q000187:drug effects*
D004791:Enzyme Inhibitors; D005233:Fatty Alcohols; D010750:Phosphoproteins; D011714:Pyrans; D000072260:RNA Splicing Factors; D017413:Ribonucleoprotein, U2 Small Nuclear; C112491:SF3B1 protein, human; C076087:herboxidiene