Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava.
The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was tested for anticancer, DPPH antioxidant, urease enzyme inhibition, α-glucosidase enzyme inhibition and acetylcholinesterase inhibition activities. Interestingly, nizwaside showed significant anti-proliferative effects on MDA MB231 breast cancer cells with an IC(50) of 23.5 µg/ml. Moreover, nizwaside was more effective than Doxorubicin, a well-known clinical anticancer drug, in suppressing MDA MB231 cell proliferation even at concentrations lower than that of Doxorubicin (75 µg/ml nizwaside vs. 100 µg/ml Doxorubicin). On the other hand, nizwaside showed relatively weak antioxidant activity with 15 % inhibition.
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman. hussainchem3@gmail.com.
Hidayat
H
Hussain
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman.|Department of Chemistry, Federal Urdu University of Arts, Science and Technolgy, Karachi, Pakistan.
Muhammad Adil
MA
Raees
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman.
Najeeb Ur
NU
Rehman
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman.
Ahmed
A
Al-Rawahi
Organische Chemie, Martin-Luther Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, 06120, Halle, Germany.
René
R
Csuk
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman.
Husain Yar
HY
Khan
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman.|Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa, 616, Sultanate of Oman.
Ghulam
G
Abbas
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman.
Mohammed Abdullah
MA
Al-Broumi
Department of Chemistry and Polymer Science, University of Stellenbosch, P/Bag X1, Matieland, 7602, South Africa.
Ivan R
IR
Green
DARIS Centre for Scientific Research and Technology Development, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman.
Ali
A
Elyassi
Department of Chemistry, Federal Urdu University of Arts, Science and Technolgy, Karachi, Pakistan.
Talat
T
Mahmood
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman. aharrasi@unizwa.edu.om.
Ahmed
A
Al-Harrasi
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D029062:Apocynaceae; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011278:Pregnanes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010936:Plant Extracts; D011278:Pregnanes; C000610905:nizwaside; C574437:pregnane glycoside
Anticancer activity; Asclepiadaceae; Desmidorchis flava; NMR; Natural product; Pregnane glycoside