[Monograph for N-Methyl-pyrrolidone (NMP) and human biomonitoring values for the metabolites 5-Hydroxy-NMP and 2-Hydroxy-N-methylsuccinimide].
1-Methyl-pyrrolidone (NMP) is used as a solvent in many technical applications. The general population may be exposed to NMP from the use as ingredient in paint and graffiti remover, indoors also from use in paints and carpeting. Because of developmental toxic effects, the use of NMP in consumer products in the EU is regulated. The developmental effects accompanied by weak maternally toxic effects in animal experiments are considered as the critical effects by the German HBM Commission. Based on these effects, HBM-I values of 10 mg/l urine for children and of 15 mg/l for adults, respectively, were derived for the metabolites 5-Hydroxy-NMP and 2-Hydroxy-N-methylsuccinimide. HBM-II-values were set to 30 mg/l urine for children and 50 mg/l for adults, respectively. Because of similar effects of the structural analogue 1-ethyl-2-pyrrolidone (NEP), the possible mixed exposure to both compounds has to be taken into account when evaluating the total burden.
D000293:Adolescent; D000328:Adult; D001681:Biological Assay / Q000592:standards*; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure / Q000032:analysis* / Q000592:standards*; D005260:Female; D005858:Germany; D017408:Guidelines as Topic; D006801:Humans; D008297:Male; D008452:Maximum Allowable Concentration; D011760:Pyrrolidinones / Q000592:standards* / Q000652:urine*; D055815:Young Adult
D011760:Pyrrolidinones; C038678:N-methylpyrrolidone
1-Methyl-2-pyrrolidone; HBM Commission; HBM values; Human Biomonitoring; NMP