Amorphous calcium phosphate, hydroxyapatite and poly(d,l-lactic acid) composite nanofibers: Electrospinning preparation, mineralization and in vivo bone defect repair.
Due to the outstanding bioactivity and biocompatibility, calcium phosphate (CaP) based materials have been widely investigated for applications in the biomedical fields. In this study, amorphous calcium phosphate (ACP) nanospheres and hydroxyapatite (HA) nanorods have been prepared and hybridized with poly(d,l-lactic acid) (PLA) to fabricate the composite nanofibers through electrospinning. The as-prepared ACP-PLA and HA-PLA composite nanofibers exhibit favorable mineralization behaviors in simulated body fluid (SBF). In the mineralization process, the ACP nanospheres and HA nanorods play an important role in the formation of HA nanosheets on the surface of composite nanofibers. The ACP-PLA and HA-PLA composite nanofibers show a high biocompatibility. The in vivo bone defect repair properties of the ACP-PLA and HA-PLA composite nanofibers are preliminarily investigated. The as-prepared ACP-PLA and HA-PLA composite nanofibers have promising applications in the biomedical fields.
Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China.
Hao
H
Zhang
Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China.
Qi-Wei
QW
Fu
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
Tuan-Wei
TW
Sun
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: fchen@mail.sic.ac.cn.
Feng
F
Chen
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
Chao
C
Qi
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
Jin
J
Wu
Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China.
Zhu-Yun
ZY
Cai
Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China. Electronic address: qianqr@163.com.
Qi-Rong
QR
Qian
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: y.j.zhu@mail.sic.ac.cn.
Ying-Jie
YJ
Zhu
D000818:Animals; D001842:Bone and Bones / Q000293:injuries*; D002113:Calcification, Physiologic; D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D018613:Microscopy, Confocal; D008854:Microscopy, Electron / Q000379:methods; D057139:Nanofibers; D011817:Rabbits; D014961:X-Ray Diffraction
D002130:Calcium Phosphates; D017886:Durapatite; C020243:calcium phosphate
Bone defect repair; Calcium phosphate; Electrospinning; Hydroxyapatite; Mineralization; Nanofiber