Unusual compounds from Galium mollugo and their inhibitory activities against ROS generation in human fibroblasts.
Three unusual dioxatricyclodecenone compounds, mollugoside A, E-mollugoside B and Z-mollugoside B and, together with known flavonoids, were isolated from the aerial parts of Galium mollugo collected in north-eastern Algeria. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR. Flavonoids and mollugoside A significantly reduced reactive oxygen species (ROS) generation in human fibroblasts.
Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la vie, Université de Bejaia, Bejaia 06000, Algérie.
Nassima
N
Chaher
Université de Bordeaux, ISVV, EA 3675 GESVAB, 33882 Villenave d'Ornon, France.
Stéphanie
S
Krisa
Université de Bordeaux, ISVV, EA 3675 GESVAB, 33882 Villenave d'Ornon, France.
Jean-Claude
JC
Delaunay
INRA-UMR 1332 BFP, Centre INRA de Bordeaux, Villenave d'Ornon, France.
Stéphane
S
Bernillon
Université de Bordeaux, ISVV, EA 3675 GESVAB, 33882 Villenave d'Ornon, France.
Eric
E
Pedrot
Université de Bordeaux, ISVV, EA 3675 GESVAB, 33882 Villenave d'Ornon, France.
Jean-Michel
JM
Mérillon
Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la vie, Université de Bejaia, Bejaia 06000, Algérie.
Djebbar
D
Atmani
Université de Bordeaux, ISVV, EA 3675 GESVAB, 33882 Villenave d'Ornon, France. Electronic address: tristan.richard@u-bordeaux.fr.
Tristan
T
Richard
D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D032061:Galium; D006801:Humans; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000032:analysis* / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000975:Antioxidants; D010936:Plant Extracts; D017382:Reactive Oxygen Species
Dioxatricyclodecenone; Flavonoids; Galium mollugo; Human fibroblasts; Mollugoside