Changes in the incidence and etiology of congenital hypothyroidism detected during 30 years of a screening program in central Serbia.
Congenital hypothyroidism (CH) is the most frequent congenital endocrine disorder. The purpose of the present study was to determine the incidence of CH in Central Serbia from 1983 to 2013. Newborn screening for CH was based on measuring neonatal thyroid-stimulating hormone (TSH) using a 30 mU/l cutoff (CO) until 12/1987 (P1), 15 mU/l until 12/1997 (P2), 10 mU/l until 12/2006 (P3), and 9 mU/l thereafter (P4). During the study period, there were 1,547,122 live births screened for CH. Primary CH was detected in 434 newborns, with incidence of 1:3728. With gradual lowering of the CO, the incidences of CH increased from 1:5943 in P1 to 1:1872 in P4 (p < 0.001). Incidence of CH with ectopic and enlarged gland doubled (p < 0.001), while prevalence of athyreosis remained relatively constant. The most prominent finding was the increase in the transient CH from none in P1 to 35 % of all CH patients in P4.


CONCLUSIONS
The overall incidence of CH in Central Serbia during study period nearly tripled, with a significant increase in almost all etiological categories, and was associated with lowering TSH cutoffs as well as other yet unidentified factors. Further studies are needed to identify other factors associated with increasing incidence of CH.


BACKGROUND
Congenital hypothyroidism (CH) is the main cause of preventable mental retardation. Recent reports have indicated a progressive increase in the incidence of primary CH throughout the world, partially explained by lowering of the TSH cutoff values.


BACKGROUND
During the study period associated with lowering of the TSH cutoffs, the overall incidence of CH in Serbia tripled, including transient CH, ectopy, and dyshormonogenesis, while prevalence of athyreosis remained stable during 30 years. Significant increase in the incidence of both permanent and transient CH was observed, associated with lowering of TSH cutoffs as well as other yet unidentified factors.
Department of Endocrinology, Institute for Mother and Child Healthcare of Serbia "Dr Vukan Čupić", Radoja Dakica 6, 11070, Belgrade, Serbia. mitrovic.sky@gmail.com.
Katarina
http://orcid.org/0000-0002-3328-8739
K
Mitrovic
Department of Endocrinology, Institute for Mother and Child Healthcare of Serbia "Dr Vukan Čupić", Radoja Dakica 6, 11070, Belgrade, Serbia. radevukovic9@gmail.com.
Rade
R
Vukovic
Department of Endocrinology, Institute for Mother and Child Healthcare of Serbia "Dr Vukan Čupić", Radoja Dakica 6, 11070, Belgrade, Serbia. tanjamil5e@gmail.com.
Tatjana
T
Milenkovic
Department of Endocrinology, Institute for Mother and Child Healthcare of Serbia "Dr Vukan Čupić", Radoja Dakica 6, 11070, Belgrade, Serbia. sladjat71@gmail.com.
Sladjana
S
Todorovic
Department of Endocrinology, Institute for Mother and Child Healthcare of Serbia "Dr Vukan Čupić", Radoja Dakica 6, 11070, Belgrade, Serbia. imd.endokrinologija@gmail.com.
Jovana
J
Radivojcevic
Department of Endocrinology, Institute for Mother and Child Healthcare of Serbia "Dr Vukan Čupić", Radoja Dakica 6, 11070, Belgrade, Serbia. draganz@eunet.rs.|Medical Faculty, University of Belgrade, Belgrade, 11000, Serbia. draganz@eunet.rs.
Dragan
D
Zdravkovic
D003409:Congenital Hypothyroidism / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D012189:Retrospective Studies; D055771:Serbia / Q000453:epidemiology; D013972:Thyrotropin / Q000097:blood*
D013972:Thyrotropin
Congenital hypothyroidism; Cutoff; Incidence; Neonatal screening; Thyroid-stimulating hormone