[Severe complications after non-intended usage of octenidine dihydrochloride. A case series with four dogs].
OBJECTIVE
Case series of four dogs in which extensive bite wounds had been treated using octenidine dihydrochloride (Octenivet® or Octenisept®) flushing. The dogs subsequently developed severe local complications.


METHODS
Retrospective evaluation of clinical symptoms, diagnostics, therapy and course of the disease.


RESULTS
In four dogs, severe necrosis and persistent edematous changes of the treated area developed after the application of octenidine dihydrochloride. The clinical course was comparable to complications described previously in human medicine. Therapy was protracted and complicated by secondary wound infection.


CONCLUSIONS
Irrigation of deep wounds, particularly bite wounds, using octenidine dihydrochloride without drainage may lead to persistent edematous changes, inflammatory reactions and necrosis. The inappropriate application of octenidine dihydrochloride for wound irrigation should be avoided in veterinary medicine.
Dr. Susanne Kaiser, Klinikum Veterinärmedizin, Klinik für Kleintiere (Chirurgie), der Justus-Liebig-Universität Gießen, Frankfurter Straße 108, 35392 Gießen, E-Mail: Susanne.M.Kaiser@vetmed.uni-giessen.de.
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Kramer
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Thiel
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000009:adverse effects*; D001733:Bites and Stings / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D004285:Dogs; D004487:Edema / Q000139:chemically induced / Q000662:veterinary; D007097:Imines; D009336:Necrosis / Q000139:chemically induced / Q000662:veterinary; D011725:Pyridines / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D007507:Therapeutic Irrigation / Q000009:adverse effects / Q000379:methods / Q000662:veterinary
D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; C034213:octenidine
Wound; edema; necrosis; octenidine dihydrochloride; veterinary medicine