Factors affecting the aluminium content of human femoral head and neck.
Tissues for the study were obtained intraoperatively during hip replacement procedures from 96 patients. In all the cases, the indication for this treatment was primary or secondary degenerative changes in the hip joint. The subject of the study was the head and neck of the femur, resected in situ. Aluminium concentrations measured in femoral head and neck samples from patients aged between 25 and 91 were varied. Statistical methods were applied to determine the variations in relation to the parameters from the background survey. Significant differences in the aluminium content of femoral head samples were observed between patients under and over 60 years of age. Based on the results, it was confirmed that the aluminium accumulates in bones over a lifetime. The study showed that the content of aluminium in the head and neck of the femur depends on the factors such as: type of medicines taken, contact with chemicals at work, differences in body anatomy and sex. The study on the levels of aluminium in bones and the factors affecting its concentration is a valuable source of information for further research on the role of aluminium in bone diseases. Based on the investigations, it was found that the GF-AAS technique is the best analytical tool for routine analysis of aluminium in complex matrix samples. The use of femoral heads in the investigations was approved by the Bioethics Committee of the University of Medical Sciences in Poznań (Poland).
Adam Mickiewicz University in Poznań, Faculty of Chemistry, Department of Analytical Chemistry, Umultowska 89b, 61-614 Poznan, Poland. Electronic address: anettazf@amu.edu.pl.
Anetta
A
Zioła-Frankowska
Department of Spine Surgery, Oncologic Orthopaedics and Traumatology, W. Dega University Hospital, Poznan University of Medical Sciences, 28 Czerwca 1956 135/147, 61-545 Poznan, Poland.
Mikołaj
M
Dąbrowski
Department of Orthopedic and Traumatology, W. Dega University Hospital, Poznan University of Medical Sciences, 28 Czerwca 1956 135/147, 61-545 Poznan, Poland.
Łukasz
Ł
Kubaszewski
Department of Spine Surgery, Oncologic Orthopaedics and Traumatology, W. Dega University Hospital, Poznan University of Medical Sciences, 28 Czerwca 1956 135/147, 61-545 Poznan, Poland.
Piotr
P
Rogala
Adam Mickiewicz University in Poznań, Faculty of Chemistry, Department of Water and Soil Analysis, Umultowska 89b, 61-614 Poznan, Poland.
Marcin
M
Frankowski
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000535:Aluminum / Q000032:analysis*; D005260:Female; D005269:Femur / Q000737:chemistry* / Q000254:growth & development; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D000535:Aluminum
Aluminium; Femoral neck and head; GFAAS technique; Health risk; Human bones