Association study between IL-17A and IL-17F gene polymorphism and myasthenia gravis in Chinese patients.
Alleles of IL-17A and IL-17F genes were reported to be associated with many inflammatory and autoimmune disorders in Asian patients. Serum level and mRNA of IL-17A in peripheral blood mononuclear cells were reported to be significantly higher in MG patients than in healthy controls. In experimental autoimmune myasthenia gravis (EAMG) animals, IL-17 may have effects on the severity of MG. This study investigated the association between four SNPs of IL-17A and IL-17F gene (rs8193036, rs2275913 and rs3748067 in IL-17A; rs763780 in IL-17F) and MG in Chinese patients. The allele frequencies were compared between 480 MG patients and 487 healthy controls, between each MG subgroup and the control group, and between each pairs of MG subgroups. Subgroups were specified by clinical features (onset age, gender, thymoma, AChRAb and muscle involvement at onset) and maximal severity during the follow-up. No associations were found between the four SNPs of IL-17A and IL-17F gene and MG in Chinese patients.
Department of Neurology, Qilu Hospital of Shandong University, 107 Wenhua West Road, 250012, Jinan, China.
Yao-Xian
YX
Yue
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Yu
Y
Hong
Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Yanchen
Y
Xie
Laboratory of Neuroimmunology, Department of Neurology, Peking University First Hospital, Beijing, China.
Hong-Jun
HJ
Hao
College of Information and Engineering, Qingdao University, Qingdao, China.
Yi
Y
Sui
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Chuan-Kai
CK
Gu
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Xu
X
Zhang
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Xiang
X
Gao
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Tian-Ping
TP
Tang
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Xian-Jun
XJ
Zhang
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Qi
Q
Wang
Department of Neurology, Qilu Hospital of Shandong University, 107 Wenhua West Road, 250012, Jinan, China. drlhf@163.com.
Hai-Feng
HF
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D007223:Infant; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012720:Severity of Illness Index; D055815:Young Adult
C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17
Gene polymorphism; IL-17A; IL-17F; Myasthenia gravis