The relationship between cardiotrophin-1 and troponin-i in coronary arterial bypass grafting on the beating heart: a prospective study.
OBJECTIVE
Cardiotrophin-1 (CT-1) is closely associated with many cardiovascular diseases, such as hypertension, myocardial infarction (MI), and heart failure, and exhibits a cardioprotective effect in ischemia-reperfusion injury. The aim of this study was to evaluate the relationship between CT-1 and Troponin-I (Tn-I) in off-pump coronary artery bypass (OPCAB) grafting on the beating heart.


METHODS
Seventy-eight patients (mean age 60.8 ± 9.7 years, 79.5% male) undergoing elective OPCAB surgery were included in this study undertaken between July 1, 2012 and July 1, 2013 in the Department of Cardiology and Cardiac Surgery, University School of Medicine Hospital. Venous blood samples were collected 5 minutes before OPCAB surgery and 6 hours after surgery. Plasma CT-1 levels were measured using the ELISA method.


RESULTS
Compared to the preoperative period, Tn-I and CT-1 values were higher in the postoperative period [0.255 ng/mL (0.030-0.430) versus 0.045 ng/mL (0.005-0.090), P &lt; .001; and 33.7 pg/mL (15.8-98.5) versus 8.7 pg/mL (0.68-25.4), P &lt; .001]. There was also an elevation in white blood cells, aspartate aminotransferase, creatine kinase (CK), and creatine kinase MB (CK-MB) values, as well as a decrease in hemoglobin values (P &lt; .001). When a correlation analysis for postoperative CT-1 was performed, there was a significant positive correlation between postoperative CK, CK-MB, and Tn-I levels (r = 0.250, P &lt; .027; r = 0.270, P = .017; and r = 0.241, P &lt; .034).


CONCLUSIONS
CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage.
Department of Cardiology, Medical Faculty, Uludag University, Bursa, Turkey.
Serhat
S
Caliskan
Department of Cardiovascular Surgery, Medical Faculty, Uludag University, Bursa, Turkey.
Feyzullah
F
Besli
Department of Cardiology, Medical Faculty, Uludag University, Bursa, Turkey.
Ahmet
A
Yildirim
Department of Cardiology, Medical Faculty, Uludag University, Bursa, Turkey.
Fatih
F
Gungoren
Department of Cardiology, Sanliurfa Mehmet Akif Inan Education and Research Hospital, Sanliurfa, Turkey.
Mehmet Fethi
MF
Alisir
Department of Cardiology, Medical Faculty, Uludag University, Bursa, Turkey.
Ufuk
U
Polat
Department of Cardiology, Medical Faculty, Uludag University, Bursa, Turkey.
Bulent
B
Ozdemir
Department of Cardiology, Bursa Anatolia Hospital, Bursa, Turkey.
Murat
M
Bicer
D015415:Biomarkers / Q000097:blood; D047549:Coronary Artery Bypass, Off-Pump / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000097:blood*; D014421:Turkey / Q000453:epidemiology
D015415:Biomarkers; D016207:Cytokines; D019210:Troponin I; C092073:cardiotrophin 1