Regional Nodal Metastasis of Humeral Chondrosarcoma in a Dog.
A 6 yr old castrated male English springer spaniel was evaluated with a 1 mo history of progressive right forelimb lameness with recent swelling around the elbow joint. Physical examination findings included lameness of the right forelimb, muscle atrophy around the right shoulder, grade 2/6 heart murmur, and moderate dental disease. Results of a complete blood cell count and serum biochemical analysis were unremarkable with the exception of a mildly increased alkaline phosphatase (368 U/L; reference range, 128-328 U/L). Radiographs of the right elbow revealed a mixed lytic and proliferative osseous lesion most consistent with either neoplasia or infection. Thoracic radiographs and the echocardiogram were unremarkable. Fine-needle aspiration of the bone lesion was performed. The cytological diagnosis was chondrosarcoma. The right forelimb was amputated and the axillary lymph nodes were collected. Histopathological examination of the bone lesion and axillary lymph nodes revealed chondrosarcoma with metastasis to the lymph nodes. Lymph node metastasis of chondrosarcoma is rare and needs to be further evaluated as a prognostic indicator.
Mandy
M
Meindel
Lisa
L
Pohlman
Brad
B
DeBey
Mary Lynn
ML
Higginbotham
From the Department of Diagnostic Medicine and Pathobiology (M.M., L.P., B.D.) and Department of Clinical Sciences (M.H., R.M.), College of Veterinary Medicine, Kansas State University, Manhattan, KS.
Rachel
R
Moon
D000671:Amputation, Surgical / Q000662:veterinary; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D002813:Chondrosarcoma / Q000473:pathology / Q000556:secondary / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D005552:Forelimb / Q000473:pathology / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin