Structural and Perfusion Abnormalities of Brain on MRI and Technetium-99m-ECD SPECT in Children With Cerebral Palsy: A Comparative Study.
Cerebral palsy has traditionally been associated with hypoxic ischemic brain damage. This study was undertaken to demonstrate structural and perfusion brain abnormalities. Fifty-six children diagnosed clinically as having cerebral palsy were studied between 1 to 14 years of age and were subjected to 3 Tesla magnetic resonance imaging (MRI). Brain and Technetium-99m-ECD brain single-photon emission computed tomography (SPECT) scan. Male to female ratio was 1.8:1 with a mean age of 4.16 ± 2.274 years. Spastic cerebral palsy was the most common type, observed in 91%. Birth asphyxia was the most common etiology (69.6%). White matter changes (73.2%) such as periventricular leukomalacia and corpus callosal thinning were the most common findings on MRI. On SPECT all cases except one revealed perfusion impairments in different regions of brain. MRI is more sensitive in detecting white matter changes, whereas SPECT is better in detecting cortical and subcortical gray matter abnormalities of perfusion.
Department of Pediatrics, Military Hospital, Jabalpur, India.
Kamer Singh
KS
Rana
Department of Pediatrics, Narayana Hrudayalaya, Bangalore, Karnataka, India.
Varun
V
Narwal
Department of Pediatrics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India lokeshchauhan07@gmail.com.
Lokesh
L
Chauhan
Department of Radiodiagnosis, Command Hospital, Southern Command, Pune, India.
Giriraj
G
Singh
Department of Obstetrics and Gynaecology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
Monica
M
Sharma
Department of Nuclear Medicine, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
Suneel
S
Chauhan
D000293:Adolescent; D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D002547:Cerebral Palsy / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D013667:Technetium / Q000493:pharmacokinetics*; D015899:Tomography, Emission-Computed, Single-Photon
D013667:Technetium
SPECT; cerebral palsy; hypoxic brain injury; magnetic resonance imaging; perfusion