Delayed tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline.
Systemic antibiotic therapy (SAT) has usually been recommended after tooth replantation, but its actual value has been questioned. As there are no reports in the literature about its influence on tooth replantation, the aim of this study was to evaluate the influence of systemic administration of antibiotics (amoxicillin and tetracycline) at the different phases of the repair process (7, 15, 30 days) in delayed rat tooth replantation. Ninety Wistar rats (Rattus norvegicus albinus) had their maxillary right incisors extracted and bench-dried for 60 min. The dental papilla, enamel organ, pulp tissue, and root surface-adhered periodontal ligament were removed, and the teeth were replanted. The animals received no antibiotics (n = 30) or were medicated systemically with amoxicillin (n = 30) and tetracycline (n = 30), and were euthanized after 7, 15, and 30 days. Regardless of the evaluation period, the acute inflammatory infiltrate was less intense and root resorption presented smaller extent and depth in the group treated with amoxicillin. The results suggest that SAT has a positive influence on the repair process in delayed tooth replantation and that amoxicillin is an excellent treatment option.
Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, SP, Brazil.
Weglis Dyanne de Souza
WD
Gomes
Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, SP, Brazil.
Cristina Antoniali
CA
Silva
Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, SP, Brazil.
Moriel Evangelista
ME
Melo
Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, SP, Brazil.
Vanessa Ferreira da
VF
Silva
Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, SP, Brazil.
Melyna Marques de
MM
Almeida
Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, SP, Brazil.
Denise
D
Pedrini
Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, SP, Brazil.
Wilson Roberto
WR
Poi
Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, SP, Brazil.
Celso Koogi
CK
Sonoda
Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, SP, Brazil.
Sônia Regina
SR
Panzarini
D000658:Amoxicillin / Q000494:pharmacology*; D000818:Animals; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012391:Root Resorption / Q000188:drug therapy; D013754:Tetracyclines / Q000494:pharmacology*; D014090:Tooth Replantation / Q000379:methods*; D014945:Wound Healing / Q000187:drug effects*
D013754:Tetracyclines; D000658:Amoxicillin
amoxicillin; delayed tooth replantation; root resorption; tetracycline