Histone hyperacetylation and exon skipping: a calcium-mediated dynamic regulation in cardiomyocytes.
In contrast to cell type-specific pre-mRNA alternative splicing, mechanisms controlling activity-dependent alternative splicing is under-studied and not well understood. In a recent study, we conducted a comprehensive analysis of calcium-mediated mechanism that regulates alternative exon skipping in mouse cardiomyocytes. Our results reveal a strong link between histone hyperacetylation and skipping of cassette exons, and provide support to the kinetic coupling model of the epigenetic regulation of alternative splicing at the chromatin level.
a Department of Genetics and Genome Sciences ; Case Western Reserve University ; Cleveland , OH USA.
Alok
A
Sharma
Hieu
H
Nguyen
Lu
L
Cai
Hua
H
Lou
D000107:Acetylation; D017398:Alternative Splicing; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002843:Chromatin / Q000235:genetics; D044127:Epigenesis, Genetic; D005091:Exons; D006657:Histones / Q000378:metabolism*; D051379:Mice; D008957:Models, Genetic; D032383:Myocytes, Cardiac / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
D002843:Chromatin; D006657:Histones; D002118:Calcium
CaMK; PKD; alternative splicing; calcium; class II HDAC; exon skipping; histone hyperacetylation