Microalbuminuria - A better marker in hypertensive disorders of pregnancy.
To assess the role of microalbuminuria in pre-eclampsia (PE) as a diagnostic marker, we studied 40 PE cases and 40 normotensive controls at 24 ± 4 weeks of gestation in women 20-35 years of age. The patients with PE had significant microalbuminuria in comparison with the controls, in addition to deranged renal function tests. The receiver operating characteristic curve showed that microalbuminuria had the highest sensitivity (100%) and good specificity (77.6%). Microalbuminuria had the highest area under the curve (0.869) for both diagnosis of PE and renal function assessment. Microalbuminuria also had a good correlation with systolic blood pressure in the cases with mild grades of renal dysfunction. Microalbuminuria is a specific marker in PE and it also helps to assess the renal function status. Therefore, microalbuminuria may be used in the early diagnosis and management of PE patients in order to reduce the immediate and long-term complications.
Ruby P
RP
Babu
Alap
A
Christy
Anupama
A
Hegde
Department of Biochemistry, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
Poornima
P
Manjrekar
Maria
M
Joseph
D000328:Adult; D000419:Albuminuria / Q000175:diagnosis* / Q000503:physiopathology; D019540:Area Under Curve; D001794:Blood Pressure; D016022:Case-Control Studies; D042241:Early Diagnosis; D005260:Female; D005865:Gestational Age; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007677:Kidney Function Tests; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index; D055815:Young Adult