Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease.
Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.
Applied Neuroscience Research Group, CEITEC MU, Masaryk University, 625 00 Brno, Czech Republic ; Department of Neurology, University Hospital in Ostrava, 708 52 Ostrava, Czech Republic ; Department of Rehabilitation, Faculty of Medicine, University of Ostrava, 708 52 Ostrava, Czech Republic.
Dagmar
D
Berankova
Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
Eva
E
Janousova
Applied Neuroscience Research Group, CEITEC MU, Masaryk University, 625 00 Brno, Czech Republic ; Department of Neurology, School of Medicine, Masaryk University and St. Anne's Hospital, 656 91 Brno, Czech Republic.
Martina
M
Mrackova
Applied Neuroscience Research Group, CEITEC MU, Masaryk University, 625 00 Brno, Czech Republic ; Department of Neurology, School of Medicine, Masaryk University and St. Anne's Hospital, 656 91 Brno, Czech Republic.
Ilona
I
Eliasova
Applied Neuroscience Research Group, CEITEC MU, Masaryk University, 625 00 Brno, Czech Republic ; Second Department of Neurology, School of Medicine, Masaryk University and Brno Teaching Hospital, 625 00 Brno, Czech Republic.
Milena
M
Kostalova
Applied Neuroscience Research Group, CEITEC MU, Masaryk University, 625 00 Brno, Czech Republic ; Second Department of Neurology, School of Medicine, Masaryk University and Brno Teaching Hospital, 625 00 Brno, Czech Republic.
Svetlana
S
Skutilova
Applied Neuroscience Research Group, CEITEC MU, Masaryk University, 625 00 Brno, Czech Republic ; Department of Neurology, School of Medicine, Masaryk University and St. Anne's Hospital, 656 91 Brno, Czech Republic.
Irena
I
Rektorova