Lamotrigine-induced tubulointerstitial nephritis and uveitis-atypical Cogan syndrome.
OBJECTIVE
To report a case of lamotrigine-induced tubulointerstitial nephritis and uveitis (TINU)-atypical Cogan syndrome.


METHODS
Case report.


RESULTS
A 16-year-old boy with traumatic brain injury and seizures presented to the emergency department with facial swelling, rash, and back pain several days after increasing lamotrigine dose secondary to a breakthrough seizure. Creatinine, urine β2 microglobulin, and eosinophils were elevated. Antinuclear antibodies, antineutrophil cytoplasmic antibodies, angiotensin-converting enzyme, and complement were normal. Renal biopsy showed acute granulomatous tubulointerstitial nephritis. Lamotrigine was discontinued, intravenous steroids were initiated, and the patient was discharged on Ativan and prednisone. Subsequently, he was diagnosed with bilateral anterior uveitis (vision 20/30 bilaterally) and started on prednisolone and cyclopentolate. Two months later, he developed a branch retinal artery occlusion in the right eye (vision 20/70) and bilateral ocular hypertension for which timolol-brimonidine and dorzolamide were added. Neuroimaging and hypercoagulability workup was unremarkable. Vision and intraocular pressure improved, while uveitis remained recalcitrant. Several months later, the patient developed central serous retinopathy in the right eye (vision 20/30). Prednisone was stopped but restarted due to methotrexate intolerance. A month later, he reported dizziness and was diagnosed with severe bilateral sensorineural hearing loss. Brain magnetic resonance imaging showed foci of perivascular, subcortical, and cochlear enhancement. Transtympanic Decadron injections and infliximab infusions were initiated. At the final visit, vision remained at 20/30 with trace anterior chamber reaction bilaterally while on timolol-brimonidine, dorzolamide, and prednisolone.


CONCLUSIONS
An idiosyncratic drug reaction should be considered in the differential diagnosis of TINU-atypical Cogan syndrome.
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA - USA.
Anton M
AM
Kolomeyer
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA - USA.
Shyam
S
Kodati
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D055952:Cogan Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005477:Fluprednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000077213:Lamotrigine; D018810:Magnetic Resonance Angiography; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D041623:Tomography, Optical Coherence; D014227:Triazines / Q000009:adverse effects*; D014605:Uveitis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
D000927:Anticonvulsants; D005938:Glucocorticoids; D014227:Triazines; D005477:Fluprednisolone; D011239:Prednisolone; C015808:difluprednate; D000077213:Lamotrigine; D011241:Prednisone