Pd catalyzed insertion of alkynes into cyclic diaryliodoniums: a direct access to multi-substituted phenanthrenes.
Cyclic diaryliodoniums remain unexplored compared to linear iodoniums. In our current work, internal alkynes were for the first time applied to react with cyclic iodoniums, catalyzed by Pd, resulting in a [4 + 2] benzannulation. Our work offers a new strategy to synthesize multi-substituted phenanthrene derivatives which are not easily accessed by conventional methods.
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou 510060, China. wenshj@sysucc.org.cn.
Yongcheng
Y
Wu
Fuhai
F
Wu
Daqian
D
Zhu
Bingling
B
Luo
Haiwen
H
Wang
Yumin
Y
Hu
Shijun
S
Wen
Peng
P
Huang
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D009861:Onium Compounds; D009942:Organometallic Compounds; D010616:Phenanthrenes; D010165:Palladium