Habitual dietary intake and mediators of the inflammaging process in Brazilian older women.
OBJECTIVE
This study aimed to assess whether the habitual intake of macronutrients by older women associates with circulating levels of important inflammaging mediators by means of a cross-sectional design with 229 Brazilian elderly women.


METHODS
Laboratory tests determined serum IL1α, IL1β, IL6, IL8, IL10, IL12 and TNFα by specific immunoassays. Food records of three alternate days were decomposed into usual intake of carbohydrates, proteins and lipids (and fractions), as well as total energy value (TEV) per patient. Moreover, the study has identified and controlled results for metabolic conditions known to influence the inflammatory profile: hypercholesterolemia, hypertension and diabetes.


CONCLUSIONS
Pearson's correlation test revealed that log10IL8 expressed a positive association with levels of saturated fatty acid (FA) (r = 0.173; p = 0.009) and total cholesterol intake (r = 0.223; p = 0.001). Similar analysis of the other mediators revealed no association with dietary intake.


CONCLUSIONS
Higher intakes of total cholesterol and saturated FA seem to correlate with increased serum IL8 levels, being a possible mechanism by which this pro-atherogenic intake pattern may increase the risk of age-related chronic diseases with important inflammatory contribution.
Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil.
Roberta Silva
RS
Paula
Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil.
Vinícius Carolino
VC
Souza
Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil.
Juliana Oliveira
JO
Toledo
Universidade Paulista, Brasília, Brazil.
Aparecido Pimentel
AP
Ferreira
Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Ciro José
CJ
Brito
Universidade Católica de Brasília, Brasilia, Brazil.
Lucy
L
Gomes
Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil.|Universidade Católica de Brasília, Brasilia, Brazil.
Clayton Franco
CF
Moraes
Universidade Católica de Brasília, Brasilia, Brazil.
Cláudio
C
Córdova
Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil. otnobrega@gmail.com.
Otávio Toledo
OT
Nóbrega
D050197:Atherosclerosis / Q000209:etiology*; D001938:Brazil; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D005227:Fatty Acids / Q000008:administration & dosage; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D018836:Inflammation Mediators / Q000097:blood*; D008055:Lipids / Q000097:blood; D008875:Middle Aged
D002791:Cholesterol, Dietary; D005227:Fatty Acids; D018836:Inflammation Mediators; D008055:Lipids
Cytokine; Diet; Inflammation; Intake; Interleukin; Nutrient