Effectiveness of low-dose pasireotide in a patient with Cushing's disease: antiproliferative effect and predictivity of a short pasireotide suppression test.
This case shows efficacy of low-dose pasireotide in biochemical and clinical control of severe hypercortisolism and in tumor volume reduction in a patient with an ACTH-secreting macroadenoma. The drug may be an option for long-term treatment in some patients where control of tumor mass is an important clinical endpoint.
Department of Endocrinology, Ospedale Niguarda Ca' Granda Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.
Erika
E
Grossrubatscher
Department of Endocrinology, Ospedale Niguarda Ca' Granda Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.
Benedetta
B
Zampetti
Department of Endocrinology, Ospedale Niguarda Ca' Granda Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.
Paolo
P
Dalino Ciaramella
Department of Neuroradiology, Ospedale Niguarda Ca' Granda Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.
Paola
P
Doneda
Department of Endocrinology, Ospedale Niguarda Ca' Granda Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.
Paola
P
Loli
ACTH-secreting macroadenoma; Cushing’s disease; antiproliferative effect; pasireotide