[Tight control of blood pressure after ischemic stroke is associated with nocturnal hypotension episodes].
OBJECTIVE
To evaluate whether a tighter blood pressure (BP) control in patients with recent ischemic stroke is associated with the presence of nocturnal hypotension (NHP) episodes.


METHODS
We included one hundred consecutive patients who had been discharged for ischemic stroke in the previous six months. To evaluate adequacy of BP control in these patients office BP and 24-h ambulatory BP monitoring values were used.


RESULTS
We studied 63 males and 37 females; mean age was 69 ± 11 years. Sixty-eight lacunar and 32 non-lacunar strokes were included. Episodes of NHP were observed in 59 patients. Clinical hypertension was present in 34 patients. An abnormal pattern of circadian rhythm of BP was present in 72 subjects. Only 18 patients had BP within normal limits. Episodes of NHP were more frequent in subjects with good BP control versus patients with bad BP control: 88.8% and 52.4 % respectively (p = 0.007). The presence of NHP episodes was also inversely related to number of BP parameters altered (p = 0.001).


CONCLUSIONS
Tight control of BP after ischemic stroke is associated with a high frequency of NHP episodes. It is likely that aggressively lowering BP levels within the normal range after an ischemic stroke may be not beneficial, particularly in elderly patients.
M C
MC
Fernandez-Moreno
Hospital de la Merced, Osuna, Espana.
L
L
Castilla-Guerra
J M
JM
Lopez-Chozas
M D
MD
Jimenez-Hernandez
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D018660:Blood Pressure Monitoring, Ambulatory; D002545:Brain Ischemia / Q000150:complications* / Q000517:prevention & control; D002940:Circadian Rhythm; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D059409:Stroke, Lacunar / Q000150:complications* / Q000517:prevention & control
D000959:Antihypertensive Agents