Novel sodium fusidate-loaded film-forming hydrogel with easy application and excellent wound healing.
To develop a novel sodium fusidate-loaded film-forming hydrogel (FFH) for easy application and excellent wound healing, various FFH formulations and corresponding FFH dried films were prepared with drug, polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), propylene glycol, ethanol and water, and their film forming times, mechanical properties, drug release, in vivo wound healing in rat and histopathology were assessed. The sodium fusidate-loaded FFH composed of sodium fusidate/PVP/PVA/propylene glycol/ethanol/water at the weight ratio of 1/2/12/3/8/74 could form a corresponding dried film in the wound sites promptly due to fast film-forming time of about 4 min. This FFH showed an appropriate hardness and adhesiveness. Furthermore, this corresponding dried film provided an excellent flexibility and elasticity, and gave relatively high drug release. As compared with the sodium fusidate-loaded commercial product, it significantly improved excision and infection wound healing in rats. This FFH was stable at 45°C for at least 6 months. Therefore, this novel sodium fusidate-loaded FFH would be an effective pharmaceutical product with easy application for the treatment of wounds.
College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea.
Dong Wuk
DW
Kim
College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea.
Kyung Soo
KS
Kim
College of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyongsan 712-749, South Korea.
Youn Gee
YG
Seo
College of Pharmacy, Ajou University, 206, Worldcup-ro, Yeongtong-gu, Suwon 443-749, South Korea.
Beom-Jin
BJ
Lee
College of Pharmacy, Ajou University, 206, Worldcup-ro, Yeongtong-gu, Suwon 443-749, South Korea.
Young Joon
YJ
Park
School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon 440-746, South Korea.
Yu Seok
YS
Youn
College of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyongsan 712-749, South Korea.
Jong Oh
JO
Kim
College of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyongsan 712-749, South Korea.
Chul Soon
CS
Yong
College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea. Electronic address: sklover777@gmail.com.
Sung Giu
SG
Jin
College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea. Electronic address: hangon@hanyang.ac.kr.
Han-Gon
HG
Choi
D000818:Animals; D065546:Drug Liberation; D004355:Drug Stability; D000431:Ethanol / Q000737:chemistry; D005672:Fusidic Acid / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D055595:Mechanical Phenomena; D008756:Methylgalactosides / Q000008:administration & dosage* / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D019946:Propylene Glycol / Q000737:chemistry; D051381:Rats; D013203:Staphylococcal Infections / Q000188:drug therapy; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects*
D008756:Methylgalactosides; C109801:hydrogel film; D014867:Water; D000431:Ethanol; D005672:Fusidic Acid; D019946:Propylene Glycol; D011142:Polyvinyl Alcohol; D011205:Povidone
Film-forming hydrogel; Film-forming time; Histological examination; Polyvinylalcohol; Polyvinylpyrrolidone; Sodium fusidate; Wound healing