An Enhanced Default Approach Bias Following Amygdala Lesions in Humans.
Approach and avoidance constitute a basic dimension of all animal behavior. Although a large number of studies have investigated approach and avoidance elicited by specific sensory stimuli, comparatively little is known about default approach biases when stimulus information is absent or reduced. The amygdala is well known to contribute to approach and avoidance behaviors in response to specific sensory stimuli; we tested whether the amygdala's role might extend to situations in which stimulus information is reduced. In a novel task, 3 patients with rare bilateral amygdala lesions (and control subjects) made approach-related judgments about photos of intact faces and of the same faces with all internal facial features occluded. Direct comparisons of the judgments of these stimuli isolated a default bias. The patients showed a greater tendency than the control subjects to rate occluded faces as more approachable than whole faces. These findings suggest that the amygdala's role in approach behavior extends beyond responses to specific stimuli.
California Institute of Technology lauraharrison@caltech.edu.
Laura A
LA
Harrison
University of Bonn.
Rene
R
Hurlemann
California Institute of Technology.
Ralph
R
Adolphs
D000328:Adult; D000679:Amygdala / Q000503:physiopathology*; D016022:Case-Control Studies; D005149:Facial Expression; D005239:Fear; D005260:Female; D006801:Humans; D007600:Judgment; D008065:Lipoid Proteinosis of Urbach and Wiethe / Q000523:psychology*; D008297:Male; D010364:Pattern Recognition, Visual; D010775:Photic Stimulation; D011930:Reaction Time; D021641:Recognition, Psychology; D012044:Regression Analysis; D055815:Young Adult
Urbach-Wiethe disease; ambiguity; amygdala; approach; avoidance; face processing; lesion; open data