Streptozotocin-Induced Diabetic Models in Mice and Rats.
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ-induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.
Strathclyde Institute of Pharmacy & Biomedical Sciences, Glasgow, Scotland, United Kingdom.
Brian L
BL
Furman
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000473:pathology* / Q000517:prevention & control; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000473:pathology; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D006943:Hyperglycemia / Q000097:blood; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000172:deficiency; D050417:Insulin-Secreting Cells / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009536:Niacinamide / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013311:Streptozocin / Q000008:administration & dosage* / Q000633:toxicity*
D007328:Insulin; D009536:Niacinamide; D013311:Streptozocin
high-fat; hyperglycemia; insulin deficiency; insulin resistance; insulitis; mouse or rat; nicotinamide; streptozotocin; type 1 diabetes mellitus; type 2 diabetes mellitus