Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity.
Tetraspanin CD82 suppresses the progression and metastasis of a wide range of solid malignant tumors. However, its roles in tumorigenesis and hematopoietic malignancy remain unclear. Ubiquitously expressed CD82 restrains cell migration and cell invasion by modulating both cell-matrix and cell-cell adhesiveness and confining outside-in pro-motility signaling. This restraint at least contributes to, if not determines, the metastasis-suppressive activity and, also likely, the physiological functions of CD82. As a modulator of cell membrane heterogeneity, CD82 alters microdomains, trafficking, and topography of the membrane by changing the membrane molecular landscape. The functional activities of membrane molecules and the cytoskeletal interaction of the cell membrane are subsequently altered, followed by changes in cellular functions. Given its pathological and physiological importance, CD82 is a promising candidate for clinically predicting and blocking tumor progression and metastasis and also an emerging model protein for mechanistically understanding cell membrane organization and heterogeneity.
Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Jin
J
Feng
Stephenson Cancer Center and Department of Physiology, University of Oklahoma Health Sciences Center, BRC 1474, 975 NE 10th Street, Oklahoma City, OK, 73104, USA.
Chao
C
Huang
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Jonathan D
JD
Wren
Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Dao-Wen
DW
Wang
Institute for Marine Biosystem and Neurosciences, Shanghai Ocean University, Shanghai, China.
Jizhou
J
Yan
Department of Biochemistry, Nanjing Medical University, Nanjing, China.
Jiexin
J
Zhang
Department of Biochemistry, Nanjing Medical University, Nanjing, China.
Yujie
Y
Sun
Department of Biochemistry, Nanjing Medical University, Nanjing, China.
Xiao
X
Han
Stephenson Cancer Center and Department of Physiology, University of Oklahoma Health Sciences Center, BRC 1474, 975 NE 10th Street, Oklahoma City, OK, 73104, USA. xin-zhang-1@ouhsc.edu.
Xin A
XA
Zhang
D002448:Cell Adhesion / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics; D021982:Cell-Matrix Junctions / Q000235:genetics; D003599:Cytoskeleton; D016147:Genes, Tumor Suppressor; D006801:Humans; D051861:Kangai-1 Protein / Q000096:biosynthesis / Q000235:genetics*; D021962:Membrane Microdomains / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction / Q000235:genetics
C497688:CD82 protein, human; D051861:Kangai-1 Protein
Cell movement; Lipid rafts; Tetraspanin; Tumor initiation; Tumor metastasis