[Profile of prescription and adequacy of treatment with non-steroidal anti-inflammatory drugs in diabetic patients].
OBJECTIVE
The aim of this study was to quantify and describe the prescription profile, as well as to assess the adequacy of treatment with non-steroidal anti-inflammatory drugs (NSAIDs) in the diabetic population of a health district.


METHODS
This is a descriptive, cross-sectional study aimed at a target population of 2,795 diabetic patients. Data were collected from the computerised clinical records of a sample of 380 individuals. The adequacy of treatment was assessed using the recommendations proposed by the Spanish societies of Rheumatology, Cardiology and Gastroenterology.


RESULTS
More than one-quarter (28%) of the diabetic patients received treatment with NSAIDs. The most commonly used ones were ibuprofen, naproxen, and dexketoprofen, with a defined daily dose per 1,000 inhabitants per day of 35.3, 17.2, and 13.2, respectively. In patients with a history of chronic kidney disease and cardiovascular high risk, fewer NSAIDs were prescribed, while they were used most frequently in patients with a risk for gastrointestinal adverse events. The prescription was considered adequate in 46.5% of diabetic patients. The main causes of inappropriate use were the inadequate prescription of NSAIDs (25.2%), and the use of any NSAID other than naproxen (20.6%).


CONCLUSIONS
The most prescribed NSAIDs were those showing a low cardiovascular risk profile. Treatment with NSAIDs was inadequate in more than half of the patients. Risk factors for cardiovascular, and especially gastrointestinal, events must be considered in order to avoid its use when not indicated, as well as the use of any NSAIDs other than naproxen.
Centro de Salud Infante D. Juan Manuel, Murcia, España. Electronic address: angaleno@hotmail.com.
A
A
Navarro-Martínez
Centro de Salud Infante D. Juan Manuel, Murcia, España.
M
M
Vidal-Martínez
Centro de Salud Infante D. Juan Manuel, Murcia, España.
I
I
García-Rosa
Centro de Salud Infante D. Juan Manuel, Murcia, España.
M J
MJ
Lázaro-Gómez
Centro de Salud Infante D. Juan Manuel, Murcia, España.
J
J
Brotons-Román
D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000139:chemically induced; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D017723:Drug Utilization Review; D057286:Electronic Health Records; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019338:Polypharmacy; D017410:Practice Guidelines as Topic; D055656:Prescriptions / Q000706:statistics & numerical data*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006442:Glycated Hemoglobin
Antiinflamatorios no esteroideos; Atención primaria de salud; Calidad de la atención sanitaria; Diabetes mellitus; Inappropriate prescription; Non-steroidal anti-inflammatory agents; Prescripción inadecuada; Primary health care; Quality of health care