Prognostic values of Notch receptors in breast cancer.
Notch receptors are frequently deregulated in several human malignancies including human breast cancer. Activation of Notch has been reported to cause mammary carcinomas in mice. However, the prognostic value of individual Notch receptors in breast cancer (BC) patients remains elusive. In the current study, we investigated the prognostic value of Notch receptors in human BC patients. More specifically, we investigated the prognostic value of four Notch receptors in breast cancer patients through "the Kaplan-Meier plotter" (KM plotter) database, in which updated gene expression data and survival information are from a total of 3554 breast cancer patients. Our results showed that Notch1 messenger RNA (mRNA) high expression was correlated to worsen overall survival (OS) in PgR-negative BC patients. Notch2, Notch3, and Notch4 mRNA high expressions were found to be correlated to better OS for all breast cancer patients. Notch2 was also found to be correlated to better OS in lymph node-negative breast cancer patients and HER2-positive breast cancer patients. These results will be useful for better understanding of the heterogeneity and complexity in the molecular biology of breast cancer and for developing tools to more accurately predict their prognosis and design their customized treatment strategies.
Department of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080. Junmingxu@hotmail.com.
Junming
J
Xu
Department of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Fangbin
F
Song
Department of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Tao
T
Jin
Department of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Jun
J
Qin
Department of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Junyi
J
Wu
Department of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Min
M
Wang
Department of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Ye
Y
Wang
Department of General Surgery, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, People's Republic of China, 200080.
Jun
J
Liu
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D053208:Kaplan-Meier Estimate; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D011960:Receptors, Estrogen / Q000235:genetics; D051880:Receptors, Notch / Q000235:genetics*; D011980:Receptors, Progesterone / Q000235:genetics
D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D051880:Receptors, Notch; D011980:Receptors, Progesterone
Estrogen receptor (ER); Hazardous ratio (HR); KM plotter; Notch receptor; Prognosis