Role of gastrointestinal hormones in feeding behavior and obesity treatment.
Food intake regulation is generally evaluated by many aspects consisting of complex mechanisms, including homeostatic regulatory mechanism, which is based on negative feedback, and hedonic regulatory mechanism, which is driven by a reward system. One important aspect of food intake regulation is the peripheral hormones that are secreted from the gastrointestinal tract. These hormones are secreted from enteroendocrine cells as feedback to nutrient and energy intake, and will communicate with the brain directly or via the vagus nerve. Gastrointestinal hormones are very crucial in maintaining a steady body weight, despite variations in nutrient intake and energy expenditure. In this review, we provide an overview of the regulation of feeding behavior by gut hormones, and its role in obesity treatments.
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.|Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia.
Timothy Sean
TS
Kairupan
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
Haruka
H
Amitani
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
Kai-Chun
KC
Cheng
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.|Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia.
Joshua
J
Runtuwene
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
Akihiro
A
Asakawa
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan. inui@m.kufm.kagoshima-u.ac.jp.
Akio
A
Inui
D001069:Appetite Regulation / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D009765:Obesity / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*
D005768:Gastrointestinal Hormones
Clinical application; Feeding behavior; Gastrointestinal hormone; Obesity