Clinical implication of human leukocyte antigen (HLA)-F expression in breast cancer.
Human leukocyte antigen (HLA)-F is one of the non-classical HLA class I molecules that protects the fetus in pregnancy. HLA-F expression was immunohistochemically examined and the association between clinical parameters and HLA-F expression was analyzed. Cancerous HLA-F and stromal HLA-F-positive infiltrating cells were detected in 91 (40.0%) and 186 (81.6%) cases, respectively. HLA-F positivity in cancer cells was significantly associated with tumor size (P < 0.05). There was a weak correlation between HLA-F positivity of cancer cells and HLA-F positive infiltrative cells (P < 0.01, r = 0.11). HLA-F positivity did not affect patients' survival in 209 breast cancer. However, confined to stage II breast cancer, the HLA-F positive group showed significantly poorer outcomes than the HLA-F negative group (P < 0.05). The present study provides the first evidence that HLA-F positivity in breast carcinoma affects clinicopathological factors and could be selected as a prognostic marker for limited clinical stage.
Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.
Aya
A
Harada
Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.
Sumiya
S
Ishigami
Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.
Yuko
Y
Kijima
Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.
Akihiro
A
Nakajo
Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.
Takaaki
T
Arigami
Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.
Hiroshi
H
Kurahara
Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.
Yoshiaki
Y
Kita
Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.
Heiji
H
Yoshinaka
Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.
Shoji
S
Natsugoe
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis / Q000276:immunology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism*; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000276:immunology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis
D014408:Biomarkers, Tumor; C062341:HLA-F antigens; D015395:Histocompatibility Antigens Class I
HLA-F; breast cancer; clinical stage; tumor infiltrating cells