Development of stem cell-based therapy for Parkinson's disease.
Parkinson's disease (PD) is one of the most common neurodegenerative disorders of aging, characterized by the degeneration of dopamine neurons (DA neurons) in the substantial nigra, leading to the advent of both motor symptoms and non-motor symptoms. Current treatments include electrical stimulation of the affected brain areas and dopamine replacement therapy. Even though both categories are effective in treating PD patients, the disease progression cannot be stopped. The research advance into cell therapies provides exciting potential for the treatment of PD. Current cell sources include neural stem cells (NSCs) from fetal brain tissues, human embryonic stem cells (hESCs), induced pluripotent stem cells (iPSCs) and directly induced dopamine neurons (iDA neurons). Here, we evaluate the research progress in different cell sources with a focus on using iPSCs as a valuable source and propose key challenges for developing cells suitable for large-scale clinical applications in the treatment of PD.
Centre for Stem Cells and Regenerative Medicine, The Liaocheng People's Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, 252000 China.
Fabin
F
Han
Centre for Stem Cells and Regenerative Medicine, The Liaocheng People's Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, 252000 China.
Deborah
D
Baremberg
Centre for Stem Cells and Regenerative Medicine, The Liaocheng People's Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, 252000 China.
Junyu
J
Gao
Centre for Stem Cells and Regenerative Medicine, The Liaocheng People's Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, 252000 China.
Jing
J
Duan
Centre for Stem Cells and Regenerative Medicine, The Liaocheng People's Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, 252000 China.
Xianjie
X
Lu
Centre for Stem Cells and Regenerative Medicine, The Liaocheng People's Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, 252000 China.
Nan
N
Zhang
Centre for Stem Cells and Regenerative Medicine, The Liaocheng People's Hospital/Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, 252000 China.
Qingfa
Q
Chen
Dopamine neuron; Human embryonic stem cells; Induced dopamine neuron; Induced pluripotent stem cell; Neural stem cell; Parkinson’s disease