Self-Assembling Peptide Nanofibrous Hydrogel on Immediate Hemostasis and Accelerative Osteosis.
The use of local agents to achieve hemostasis of bone that does not interfere with repair and recovery is a complex and emergency subject in surgery. In this study, the dual functional biodegradable self-assembling nanopeptide (SAP) RADA16-I was synthesized by solid phase synthesis and was shown to exhibit immediate hemostasis and accelerative osteosis. The RADA16-I showed good performance as a hemostatic agent, which was investigated by comparison with the effects of bone wax in the ilium bone defect model of New Zealand rabbits. The RADA16-I exhibited efficient function of bone regeneration in both radiographic analysis and histological examination, while the bone wax inhibited osteogenesis. Moreover, in in vivo experiment, the RADA16-I was shown to exhibit excellent biocompatibility, while the group with bone wax showed a severe inflammatory response at the interface with bone. Thus, the RADA16-I is proven to be an excellent biocompatible material with effective dual function of hemostasis and osteosis.
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University , Chengdu, 610041 Sichuan, China.|Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital of Sichuan University , Chengdu, 610041 Sichuan, China.
Min
M
Wu
Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital of Sichuan University , Chengdu, 610041 Sichuan, China.
Zhaoyang
Z
Ye
Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University , Chengdu, 610041 Sichuan, China.
Hongyan
H
Zhu
Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital of Sichuan University , Chengdu, 610041 Sichuan, China.|Center for Biomedical Engineering, NE47-379, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139-4307, United States.
Xiaojun
X
Zhao
D000818:Animals; D006487:Hemostasis; D020100:Hydrogels / Q000737:chemistry*; D057139:Nanofibers; D010455:Peptides / Q000737:chemistry*; D011817:Rabbits
D020100:Hydrogels; D010455:Peptides