Systematic review of drug utilization studies & the use of the drug classification system in the WHO-SEARO Region.
OBJECTIVE
Information available on drug consumption is inadequate in most low and middle income countries. This systematic review was conducted to analyse published work on drug utilization research/studies (DUR) in the SEARO region of WHO for study objectives, methodology, results and recommendations and to identify the need for improving DUR and the use of the ATC/DDD system.


METHODS
A literature search for DUR was carried out in biomedical databases (PubMed, Scirus, Scopus and Google Scholar) up to May 2012. Publications were selected if those were in the English language, describing DUR or prescription practices, and study conducted in the WHO-SEARO countries.


RESULTS
A total of 318 publications were included in the review. Of these, 67 per cent were from India and 13 per cent were from Thailand. Majority of the publications were hospital based; only 16 per cent were community based. The ATC/DDD system was used in only 20 per cent of the publications, of which 73 per cent publications used DDD indicators. Several publications focused on antibiotics (31%). Publications that recommended the need for a policy or intervention to improve prescription practices/rational drug use amounted to 35 per cent.


CONCLUSIONS
Drug utilization studies using ATC/DDD system need to be promoted and carried out on an ongoing basis. DUR is important for rational use of drugs. Its relevance to policy making and resource allocation needs to be emphasized.
Sagar S
SS
Bachhav
Office of National Chair in Clinical Pharmacology (ICMR), Employees' State Insurance Corporation's (ESIC), Post Graduate Institute of Medical Science & Research, Mahatma Gandhi Memorial Hospital, Mumbai; National Institute for Research in Reproductive Health (ICMR), J.M. Street, Parel, Mumbai 400 012, Maharashtra, India.
Nilima A
NA
Kshirsagar
D000900:Anti-Bacterial Agents / Q000145:classification / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004363:Drug Utilization; D006801:Humans; D007194:India; D055553:Prescription Drugs / Q000145:classification / Q000627:therapeutic use*; D013785:Thailand; D014944:World Health Organization
D000900:Anti-Bacterial Agents; D055553:Prescription Drugs