Review of combined liver and kidney transplantation in children.
In this review, we focused on CLKT with regard to indication, results, outcome, and future developments. PH1 is one of the most common diagnoses for adult and pediatric patients qualifying for CLKT. The other major indication for combined transplantation is ARPKD. CLKT appears to be superior to sequential liver and kidney transplantation in the majority of patients and overall results following CLKT are now good, even in small children. Clinical observations suggest that there is an immunological advantage of CLKT in comparison with isolated liver or kidney transplantation. More clinical studies are necessary to identify the best candidates for CLKT while the availability of donor organs is low.
Department of Pediatrics, University Medical Center, Bonn, Germany.
Rainer
R
Ganschow
Department of Pediatrics, University Medical Center, Bonn, Germany.
Bernd
B
Hoppe
D002648:Child; D058625:End Stage Liver Disease / Q000150:complications / Q000601:surgery*; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D016031:Liver Transplantation / Q000379:methods*; D019990:Perioperative Care / Q000379:methods; D011183:Postoperative Complications; D016896:Treatment Outcome
D007166:Immunosuppressive Agents
immunosuppression; indications; liver and kidney transplantation; outcome