Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies.
Based on extensive pre-clinical achievements over the past decades, it appears to be due time for a successful clinical translation in the renal fibrosis field-but what is the quickest road to get there? In light of the recent launch of the Precision Medicine Initiative and success of molecularly informed drugs in oncology, we here discuss what it may take to bring molecularly targeted anti-fibrotic to clinical use in chronic progressive kidney disease.
Department of Nephrology and Rheumatology, University Medical Center Göttingen, Georg August University, Robert Koch Str. 40, 37075 Göttingen, Germany.
Michael
M
Zeisberg
Department of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany ; German Center for Cardiovascular Research (DZHK), Robert Koch Street 40, Göttingen, Germany.
Elisabeth M
EM
Zeisberg
Clinical trial; Epigenetics; Fibrosis; Liquid biopsy; Precision medicine