Translational metabolomics in cancer research.
Over the last decade there has been a bottleneck in the introduction of new validated cancer metabolic biomarkers into clinical practice. Unfortunately, there are no biomarkers with adequate sensitivity for the early detection of cancer, and there remain a reliance on cancer antigens for monitoring treatment. The need for new diagnostics has led to the exploration of untargeted metabolomics for discovery of early biomarkers of specific cancers and targeted metabolomics to elucidate mechanistic aspects of tumor progression. The successful translation of such strategies to the treatment of cancer would allow earlier intervention to improve survival. We have reviewed the methodology that is being used to achieve these goals together with recent advances in implementing translational metabolomics in cancer.
Penn SRP Center & Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania, PA 19104, USA.|AJ Drexel Autism Institute, Drexel University, PA 19104, USA.
Nathaniel W
NW
Snyder
Penn SRP Center & Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania, PA 19104, USA.
Clementina
C
Mesaros
Penn SRP Center & Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania, PA 19104, USA.
Ian A
IA
Blair
D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D055432:Metabolomics / Q000379:methods*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D057170:Translational Research, Biomedical / Q000379:methods*
NMR spectroscopy; cancer; cancer diagnosis; diagnostic biomarkers; lipidomics; liquid chromatography-mass spectrometry; prognostic biomarkers; untargeted metabolomics targeted metabolomics