CD5 as a Target for Immune-Based Therapies.
CD5 was one of the first surface receptors described for mouse and human T lymphocytes. Since then, it has been found to be highly expressed by regulatory T cells and a subpopulation of regulatory B cells, to be physically associated with the T- and B-cell antigen receptors, to negatively modulate TCR- and BCR-mediated signals, and to bind certain pathogen-associated molecular patterns. These findings position CD5 as an attractive target for developing immunotherapies aimed at either boosting or dampening ongoing immune responses. Here the available data on the function of CD5 and its involvement in the regulation of immune responses in health and disease are reviewed, as well as the evidence for and future challenges in developing therapeutic strategies aimed at targeting CD5 for autoimmune diseases, cancer, and infections.
Group of Immune Receptors of the Innate and Adaptive System, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Marta
M
Consuegra-Fernández
Group of Immune Receptors of the Innate and Adaptive System, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Fernando
F
Aranda
Group of Immune Receptors of the Innate and Adaptive System, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Inês
I
Simões
Group of Immune Receptors of the Innate and Adaptive System, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Marc
M
Orta
Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Adelaida
A
Sarukhan
Group of Immune Receptors of the Innate and Adaptive System, IDIBAPS; Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona; Servei d'Immunologia, Hospital Clinic de Barcelona, Barcelona, Spain.
Francisco
F
Lozano
D000818:Animals; D001327:Autoimmune Diseases / Q000628:therapy*; D016175:B-Lymphocyte Subsets; D060151:B-Lymphocytes, Regulatory / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D018956:CD5 Antigens / Q000737:chemistry / Q000378:metabolism*; D002470:Cell Survival; D006801:Humans; D007167:Immunotherapy; D007239:Infections / Q000628:therapy; D008213:Lymphocyte Activation; D051379:Mice; D009369:Neoplasms / Q000628:therapy; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
D018956:CD5 Antigens