A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis.
Mucoepidermoid carcinoma ex pleomorphic adenoma (MCxPA) is a rare salivary gland tumor predominantly found in major salivary glands. A case of MCxPA involving the soft tissue and bone of the retromolar region of a 26-year-old man is presented. The histopathological features revealed a neoplasm with predominance of pleomorphic adenoma (PA) elements, and presence of mucoepidermoid carcinoma malignant epithelial cells in several areas. Histochemical and immunohistochemical studies were positive for periodic acid Schiff, alcian blue, cytokeratins 7, 13, 14, and 19, Bcl-2, c-erbB-2, FGF-2 and maspin in the malignant areas. The patient underwent a partial resection of the left side of the mandible with neck dissection and MCxPA diagnosis was confirmed.
PhD Student, Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Santa Catarina, University Campus, Trindade CEP: 88040-900, Florianopolis, SC, Brazil, Phone: +55 (48) 3721-3483, e-mail: felipedaltoe@usp.br.
Felipe Perozzo
FP
Daltoe
Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Santa Catarina, Brazil.
Liliane Janete
LJ
Grando
Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Santa Catarina, Brazil.
Maria Inês
MI
Meurer
Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Santa Catarina, Brazil.
Elena Riet Correa
ER
Rivero
Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Santa Catarina, Brazil.
Filipe
F
Modolo
D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000328:Adult; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology*; D005346:Fibroblast Growth Factors / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D053535:Keratin-13 / Q000032:analysis; D053547:Keratin-14 / Q000032:analysis; D053539:Keratin-19 / Q000032:analysis; D053552:Keratin-7 / Q000032:analysis; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology*; D015842:Serine Proteinase Inhibitors / Q000032:analysis; D015843:Serpins / Q000032:analysis
D005346:Fibroblast Growth Factors; D053535:Keratin-13; D053547:Keratin-14; D053539:Keratin-19; D053552:Keratin-7; D019253:Proto-Oncogene Proteins c-bcl-2; D018719:Erb-b2 Receptor Tyrosine Kinases; D015842:Serine Proteinase Inhibitors; D015843:Serpins; C416003:FGF20 protein, human; C085344:SERPIN-B5
Ex pleomorphic adenoma; Mucoepidermoid carcinoma; Salivary gland; Immunohistochemistry