Oxidative stress, inflammation, and markers of cardiovascular health.
OBJECTIVE
To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein- (LDL)-cholesterol, high-density lipoprotein- (HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood cell [WBC] counts) among 19,825 participants in a nationwide study.


METHODS
Using cross-sectional data 14 dietary and lifestyle components were incorporated into the OBS and the resulting score (range 3-26) was then divided into five equal intervals. Multivariable-adjusted odds ratios (ORs) for abnormal biomarker levels and 95% confidence intervals (CIs) were calculated using logistic regression models.


RESULTS
The ORs (95% CIs) comparing those in the highest relative to those in the lowest OBS equal interval categories were 0.50 (0.38-0.66) for CRP, 0.50 (0.36-0.71) for the total WBC count, and 0.75 (0.58-0.98) for LDL-cholesterol; all three p-values for trend were <0.001. The OBS-HDL-cholesterol association was statistically significantly inverse among females, but not among males. The OBS was not associated with serum albumin or triglycerides.


CONCLUSIONS
Our findings suggest that an OBS may be associated with some, but not all, circulating lipids/lipoproteins and biomarkers of inflammation.
Department of Nutrition, Emory University, Atlanta, GA, USA; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: slakkur@uab.edu.
Sindhu
S
Lakkur
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Suzanne
S
Judd
Department of Nutrition, Emory University, Atlanta, GA, USA; Department of Epidemiology, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Roberd M
RM
Bostick
Department of Epidemiology, Emory University, Atlanta, GA, USA.
William
W
McClellan
Department of Epidemiology, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
W Dana
WD
Flanders
Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Victoria L
VL
Stevens
Department of Nutrition, Emory University, Atlanta, GA, USA; Department of Epidemiology, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Michael
M
Goodman
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000473:pathology*; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D006801:Humans; D007249:Inflammation; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D018384:Oxidative Stress; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D008076:Cholesterol, HDL; D012709:Serum Albumin; D014280:Triglycerides; D002097:C-Reactive Protein
Epidemiology; Inflammation; Lipoproteins; Oxidative stress