Isogarcinol Extracted from Garcinia mangostana L. Ameliorates Systemic Lupus Erythematosus-like Disease in a Murine Model.
Isogarcinol is a new immunosuppressant that we extracted from Garcinia mangostana L. In the present study, we elucidate its beneficial effect in chronic graft-versus-host disease (cGVHD) in mice -- a model for systemic lupus erythematosus (SLE) in human. The oral administration of 60 mg/kg isogarcinol significantly reduced proteinuria, corrected the abnormal serum biochemical indicator, and decreased the amount of serum antibodies and lowered the renal histopathology score. In addition, isogarcinol alleviated the abnormal activation of CD4 T cells and decreased the expression of inflammatory genes and cytokines in the kidneys and peritoneal macrophages. The mechanism of action of isogarcinol is associated with downregulation of CD4 T cells and inflammatory effects. Therefore, we believe that isogarcinol may be a potential therapeutic drug candidate for future treatment of SLE.
Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory, Beijing Normal University , Beijing 100875, PR China.
Wei
W
Li
Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory, Beijing Normal University , Beijing 100875, PR China.
Hu
H
Li
Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory, Beijing Normal University , Beijing 100875, PR China.
Mu
M
Zhang
Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory, Beijing Normal University , Beijing 100875, PR China.
Youxiu
Y
Zhong
Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory, Beijing Normal University , Beijing 100875, PR China.
Mengqi
M
Wang
Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory, Beijing Normal University , Beijing 100875, PR China.|Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources, Ministry of Education, College of Landscape and Horticulture, Hainan University , Haikou 570228, PR China.
Juren
J
Cen
College of Pharmacy, Hubei University of Chinese Medicine , Wuhan 430061, PR China.
Hezhen
H
Wu
College of Pharmacy, Hubei University of Chinese Medicine , Wuhan 430061, PR China.
Yanfang
Y
Yang
Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory, Beijing Normal University , Beijing 100875, PR China.
Qun
Q
Wei
D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D029762:Garcinia mangostana / Q000737:chemistry*; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013729:Terpenes / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification
D016207:Cytokines; D007166:Immunosuppressive Agents; D010936:Plant Extracts; D013729:Terpenes; C054597:garcinol
CD4 T cells; Garcinia mangostana L.; chronic graft versus host disease; inflammation; isogarcinol; systemic lupus erythematosus