The myth of 0.9% saline: neither normal nor physiological.
Normal saline is the crystalloid of choice for fluid resuscitation with its utility born out of the cholera epidemic of 1832. However, its ubiquitous usage is being challenged because of a growing body of evidence suggesting that a large volume infusion of normal saline does in fact have deleterious effects on multiple body systems. Careful considerations should be given to the physiological effects of using large amounts of normal saline as one would with another pharmacological agents.
Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, and New York University College of Nursing, New York.
Leon
L
Chen
D000818:Animals; D064648:Critical Care Nursing; D005440:Fluid Therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007552:Isotonic Solutions / Q000627:therapeutic use*; D008991:Monitoring, Physiologic; D012965:Sodium Chloride / Q000627:therapeutic use*
D007552:Isotonic Solutions; D012965:Sodium Chloride