Synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles under catalyst-free conditions.
A convenient procedure for the synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles has been developed. By using KO(t)Bu as the promotor with 2-aminopyridines or amidines as the reaction partner, the desired heterocycles were produced in moderate to good yields under catalyst-free conditions.
Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province 310018, People's Republic of China. xiao-feng.wu@catalysis.de and Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
Jian-Bo
JB
Feng
Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province 310018, People's Republic of China. xiao-feng.wu@catalysis.de and Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
Xiao-Feng
XF
Wu