Deciphering Asthma Biomarkers with Protein Profiling Technology.
Asthma is a chronic inflammatory disease of the airways, resulting in bronchial hyperresponsiveness with every allergen exposure. It is now clear that asthma is not a single disease, but rather a multifaceted syndrome that results from a variety of biologic mechanisms. Asthma is further problematic given that the disease consists of many variants, each with its own etiologic and pathophysiologic factors, including different cellular responses and inflammatory phenotypes. These facets make the rapid and accurate diagnosis (not to mention treatments) of asthma extremely difficult. Protein biomarkers can serve as powerful detection tools in both clinical and basic research applications. Recent endeavors from biomedical researchers have developed technical platforms, such as cytokine antibody arrays, that have been employed and used to further the global analysis of asthma biomarker studies. In this review, we discuss potential asthma biomarkers involved in the pathophysiologic process and eventual pathogenesis of asthma, how these biomarkers are being utilized, and how further testing methods might help improve the diagnosis and treatment strain that current asthma patients suffer.
RayBiotech, Inc., Guangzhou 510600, China ; RayBiotech, Inc., 3607 Parkway Lane, Norcross, GA 30092, USA ; South China Biochip Research Center, Guangzhou 510600, China.
Zhizhou
Z
Kuang
RayBiotech, Inc., 3607 Parkway Lane, Norcross, GA 30092, USA.
Jarad J
JJ
Wilson
RayBiotech, Inc., Guangzhou 510600, China ; RayBiotech, Inc., 3607 Parkway Lane, Norcross, GA 30092, USA ; South China Biochip Research Center, Guangzhou 510600, China.
Shuhong
S
Luo
RayBiotech, Inc., Guangzhou 510600, China.
Si-Wei
SW
Zhu
RayBiotech, Inc., Guangzhou 510600, China ; RayBiotech, Inc., 3607 Parkway Lane, Norcross, GA 30092, USA ; South China Biochip Research Center, Guangzhou 510600, China.
Ruo-Pan
RP
Huang