Novel reassortant influenza viruses between pandemic (H1N1) 2009 and other influenza viruses pose a risk to public health.
Influenza A virus (IAV) is characterized by eight single-stranded, negative sense RNA segments, which allows for gene reassortment among different IAV subtypes when they co-infect a single host cell simultaneously. Genetic reassortment is an important way to favor the evolution of influenza virus. Novel reassortant virus may pose a pandemic among humans. In history, three human pandemic influenza viruses were caused by genetic reassortment between avian, human and swine influenza viruses. Since 2009, pandemic (H1N1) 2009 (pdm/09 H1N1) influenza virus composed of two swine influenza virus genes highlighted the genetic reassortment again. Due to wide host species and high transmission of the pdm/09 H1N1 influenza virus, many different avian, human or swine influenza virus subtypes may reassert with it to generate novel reassortant viruses, which may result in a next pandemic among humans. So, it is necessary to understand the potential threat of current reassortant viruses between the pdm/09 H1N1 and other influenza viruses to public health. This study summarized the status of the reassortant viruses between the pdm/09 H1N1 and other influenza viruses of different species origins in natural and experimental conditions. The aim of this summarization is to facilitate us to further understand the potential threats of novel reassortant influenza viruses to public health and to make effective prevention and control strategies for these pathogens.
Key Laboratory of Food Nutrition and Safety (Tianjin University of Science & Technology), Ministry of Education of China, Tianjin 300457, China.
Weili
W
Kong
Shanghai Key Laboratory of Agricultural Genetic Breeding, Biotech Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.
Feibing
F
Wang
Key Laboratory of Food Nutrition and Safety (Tianjin University of Science & Technology), Ministry of Education of China, Tianjin 300457, China.
Bin
B
Dong
College of Animal Science, Henan Institute of Science and Technology, Xinxiang 453000, China.
Changbo
C
Ou
Key Laboratory of Food Nutrition and Safety (Tianjin University of Science & Technology), Ministry of Education of China, Tianjin 300457, China.
Demei
D
Meng
Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China.
Jinhua
J
Liu
Key Laboratory of Food Nutrition and Safety (Tianjin University of Science & Technology), Ministry of Education of China, Tianjin 300457, China; Obesita & Algaegen LLC, College Station, TX 77845, USA. Electronic address: fanzhen@tust.edu.cn.
Zhen-Chuan
ZC
Fan
D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology; D016865:Reassortant Viruses / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*
Canine influenza; Human influenza; Pdm/09 H1N1; Reassortant; Swine influenza