[Faecal calprotectin as an aid to the diagnosis of non-IgE mediated cow's milk protein allergy].
BACKGROUND
The aim of the study was to assess the use of faecal calprotectin (FCP) in infants with signs and symptoms of non-IgE-mediated cow's milk protein allergy (CMA) for both diagnosis and prediction of clinical response at the time of withdrawal of milk proteins.


METHODS
A one year prospective study was conducted on 82 infants between 1 and 12 months of age in the Eastern area of Málaga-Axarquía, of whom 40 of them had been diagnosed with non-IgE-mediated CMA (with suggestive symptoms and positive response to milk withdrawal), 12 not diagnosed with CMA, and 30 of them were the control group. FCP was measured at three different times: time of diagnosis, and one and three months later. ANOVA for repeated measures, nominal logistic regression and ROC curves were prepared using the SPSS.20 package and Medcalc.


RESULTS
Differences between diagnostic and control groups were assessed: there was a statistically significant relationship (p<.0001) between high FCP levels and infants suffering CMA, as well as the levels at time of diagnosis, 1 and 3 months (p <.001). A ROC curve was constructed between FCP levels and diagnosis of CMA, with 138 ug/g, with the best cut-off being with an area under the curve of 0.89. However, it is only 0.68 to predict a clinical response.


CONCLUSIONS
FCP levels lower than 138ug/g could be useful to rule out non-IgE-mediated CMA diagnosis. Calprotectin is not a good test to predict clinical response to milk withdrawal.
UGC de Pediatría, Área Este de Málaga, Anarquía , Málaga, España. Electronic address: trillobelizon@gmail.com.
Carlos
C
Trillo Belizón
UGC Maracena, Distrito Granada-Metropolitano, Málaga, España.
Eduardo
E
Ortega Páez
UGC de Pediatría, Área Este de Málaga, Anarquía , Málaga, España.
Antonio F
AF
Medina Claros
UGC de Pediatría, Área Este de Málaga, Anarquía , Málaga, España.
Isabel
I
Rodríguez Sánchez
UGC de Pediatría, Área Este de Málaga, Anarquía , Málaga, España.
Ana
A
Reina González
UGC de Pediatría, Área Este de Málaga, Anarquía , Málaga, España.
Rafael
R
Vera Medialdea
UGC de Pediatría, Área Este de Málaga, Anarquía , Málaga, España.
José Manuel
JM
Ramón Salguero
D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E; D007223:Infant; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D016269:Milk Hypersensitivity / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D008894:Milk Proteins / Q000009:adverse effects* / Q000276:immunology; D011446:Prospective Studies
D039841:Leukocyte L1 Antigen Complex; D008894:Milk Proteins; D007073:Immunoglobulin E
Alergia a proteínas de leche de vaca; Calprotectina fecal; Cow's milk allergy; Faecal calprotectin; Immunoglobulin E; Inmunoglobulina E