Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation.
Antibodies named TcCRA "Trypanosoma cruzi Cross Reactive Antibodies" were detected in 47% of blood donors from French population unexposed to the parasite. In order to evaluate the passive or active transmissibility of TcCRA and further characterize its role and etiology, we have conducted a study in a cohort of 47 patients who underwent allogeneic Hematopoietic Stem Cell Transplantations (allo-HSCT). Donors and recipients were tested for TcCRA prior to transplantation. Recipients were further tested during follow-up after transplantation. Demographical, clinical and biological data were collected. Our primary end-point was to assess the risk of TcCRA acquisition after transplantation. During this initial analysis, we observed no seroconversion in patients receiving cells from TcCRA negative donors (n = 23) but detected seroconversion in 4 out of 24 patients who received hematopoietic stem cells from positive donors. Here, we are discussing possible scenarios to explain TcCRA-immune status in recipient after transplantation.
INFYNITY-Biomarkers, Lyon, France; Laboratories of Bacteriology-Virology, GIMAP EA3064, Faculty of Medicine Jacques Lisfranc, Saint-Etienne, France.
Esber S
ES
Saba
INFYNITY-Biomarkers, Lyon, France.
Lucie
L
Gueyffier
INFYNITY-Biomarkers, Lyon, France.
Marie-Laure
ML
Danjoy
Hospices Civils de Lyon, Lyon, France.
Philippe
P
Vanhems
Laboratories of Bacteriology-Virology, GIMAP EA3064, Faculty of Medicine Jacques Lisfranc, Saint-Etienne, France.
Bruno
B
Pozzetto
Hospices Civils de Lyon, Lyon, France.
Mohamad
M
Sobh
Interdisciplinary Research Center, Catholic University Leuven, Kortrijk, Belgium.
Hans
H
Pottel
Hospices Civils de Lyon, Lyon, France.
Mauricette
M
Michallet
INFYNITY-Biomarkers, Lyon, France; Hospices Civils de Lyon, Lyon, France.
Maan A
MA
Zrein
D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology*; D001803:Blood Transfusion; D014355:Chagas Disease / Q000097:blood / Q000276:immunology / Q000635:transmission*; D003587:Cytomegalovirus / Q000276:immunology / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000635:transmission; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000097:blood / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D012699:Serology; D066027:Transplant Recipients; D014349:Trypanosoma cruzi / Q000276:immunology / Q000472:pathogenicity
D000913:Antibodies, Protozoan