Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH.
The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal or increased skin pH. A pH 4 W/O emulsion was applied on three areas with pathologically increased skin surface pH in diabetics (n = 10). Further, a 28-day half-side trial (n = 30) was performed to test the long-term efficacy and safety of a pH 4 W/O emulsion (n = 30). In summary, the application of a pH 4 W/O emulsion reduced the skin pH in healthy, elderly and diabetic subjects, which may improve epidermal barrier functions.
Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.
Barbara
B
Behm
Michael
M
Kemper
Philipp
P
Babilas
Christoph
C
Abels
Stephan
S
Schreml
D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D004655:Emulsions / Q000008:administration & dosage* / Q000737:chemistry; D006016:Glycolates; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000737:chemistry* / Q000378:metabolism; D016896:Treatment Outcome; D014867:Water / Q000008:administration & dosage* / Q000737:chemistry
D004655:Emulsions; D006016:Glycolates; D008055:Lipids; D014867:Water; C031149:glycolic acid