Childhood diarrhoea in Danish day care centres could be associated with infant colic, low birthweight and antibiotics.
OBJECTIVE
Diarrhoea is very common in children attending day care centres. The aim of this study was to examine certain predisposing risk factors for an association with diarrhoea, including foreign travel, treatment with antibiotics, having household pets, infant colic, bottle feeding, using a pacifier and low birthweight.


METHODS
A dynamic one-year follow-up cohort study comprising 179 children from 36 day care centres was conducted from September 2009 to July 2013 in Copenhagen, Denmark. Questionnaires were sent to the children's parents or legal guardians every two months for a year, requesting information on gastrointestinal symptoms and exposure. A logistic regression was performed to identify the odds ratios of different risk factors for diarrhoea.


RESULTS
The odds ratios for diarrhoea were 1.97 (0.93-4.20) for children with a history of infant colic, 1.91 (0.90-4.04) for low birthweight children and 1.45 (0.74-2.82) for children who had used antibiotics. Having a pet in the household had a possible protective effect towards diarrhoeal events, with an odds ratio of 0.47 (0.20-1.09).


CONCLUSIONS
A history of infant colic, low birthweight, and to a lesser extent antibiotic use, possibly increased the risk of diarrhoea in Danish children in day care centres.
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Betina
B
Hebbelstrup Jensen
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.|Department of Paediatrics, Hvidovre University Hospital, Copenhagen, Denmark.
Dennis
D
Röser
H.C. Andersen's Children's Hospital, University of Odense, Odense, Denmark.
Bente Utoft
BU
Andreassen
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Katharina E P
KE
Olsen
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Henrik Vedel
HV
Nielsen
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Bent Bjørn
BB
Roldgaard
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Susanne
S
Schjørring
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Hengameh Chloé
HC
Mirsepasi-Lauridsen
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Steffen L
SL
Jørgensen
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Esben Munk
EM
Mortensen
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.|Department of Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark.|Department of Clinical Microbiology, Hvidovre University Hospital, Copenhagen, Denmark.
Andreas Munk
AM
Petersen
Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Karen Angeliki
KA
Krogfelt
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002656:Child Day Care Centers; D002675:Child, Preschool; D003085:Colic / Q000150:complications*; D003718:Denmark; D003967:Diarrhea / Q000209:etiology*; D003968:Diarrhea, Infantile / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D011795:Surveys and Questionnaires
D000900:Anti-Bacterial Agents
Child day care centres; Cohort study; Diarrhoea; epidemiology