Annual Costs of Care for Pediatric Irritable Bowel Syndrome, Functional Abdominal Pain, and Functional Abdominal Pain Syndrome.
OBJECTIVE
To estimate annual medical and nonmedical costs of care for children diagnosed with irritable bowel syndrome (IBS) or functional abdominal pain (syndrome; FAP/FAPS).


METHODS
Baseline data from children with IBS or FAP/FAPS who were included in a multicenter trial (NTR2725) in The Netherlands were analyzed. Patients' parents completed a questionnaire concerning usage of healthcare resources, travel costs, out-of-pocket expenses, productivity loss of parents, and supportive measures at school. Use of abdominal pain related prescription medication was derived from case reports forms. Total annual costs per patient were calculated as the sum of direct and indirect medical and nonmedical costs. Costs of initial diagnostic investigations were not included.


RESULTS
A total of 258 children, mean age 13.4 years (±5.5), were included, and 183 (70.9%) were female. Total annual costs per patient were estimated to be €2512.31. Inpatient and outpatient healthcare use were major cost drivers, accounting for 22.5% and 35.2% of total annual costs, respectively. Parental productivity loss accounted for 22.2% of total annual costs. No difference was found in total costs between children with IBS or FAP/FAPS.


CONCLUSIONS
Pediatric abdominal pain related functional gastrointestinal disorders impose a large economic burden on patients' families and healthcare systems. More than one-half of total annual costs of IBS and FAP/FAPS consist of inpatient and outpatient healthcare use.


BACKGROUND
Netherlands Trial Registry: NTR2725.
Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital AMC, Amsterdam, The Netherlands.
Daniël R
DR
Hoekman
Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital AMC, Amsterdam, The Netherlands.
Juliette M T M
JM
Rutten
Department of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands.
Arine M
AM
Vlieger
Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital AMC, Amsterdam, The Netherlands.
Marc A
MA
Benninga
Clinical Research Unit, Academic Medical Center, Amsterdam, The Netherlands.
Marcel G W
MG
Dijkgraaf
D015746:Abdominal Pain / Q000191:economics / Q000209:etiology / Q000628:therapy*; D000293:Adolescent; D002648:Child; D003695:Delivery of Health Care / Q000191:economics*; D019468:Disease Management; D005260:Female; D005767:Gastrointestinal Diseases / Q000191:economics / Q000209:etiology / Q000628:therapy*; D017048:Health Care Costs / Q000639:trends*; D005102:Health Expenditures; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000191:economics / Q000628:therapy*; D008297:Male; D009426:Netherlands; D011795:Surveys and Questionnaires