Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis.
We report a case involving a 43-year-old Japanese woman with steroid-resistant focal segmental glomerular sclerosis (FSGS) and severe renal dysfunction, which was ameliorated by low-density lipoprotein apheresis (LDL-A). She had been treated with steroid therapy, but had experienced anuria for over 10 weeks and required hemodialysis. She was then treated with LDL-A, which resulted in improved urinary protein excretion and renal function. Her renal function recovered after 97 days of hemodialysis therapy. This case suggests that LDL-A may represent an effective rescue treatment in patients with FSGS and long-term anuria.
Department of Medicine, Shiga University of Medical Science, Japan.
Hisazumi
H
Araki
Shinya
S
Ono
Yuka
Y
Nishizawa
Naoko
N
Deji
Jun
J
Nakazawa
Yoshikata
Y
Morita
Shinji
S
Kume
Masami
M
Chin-Kanasaki
Keiji
K
Isshiki
Shin-ichi
S
Araki
Tetsuro
T
Arimura
Hiroshi
H
Maegawa
Takashi
T
Uzu
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D001002:Anuria / Q000209:etiology*; D004351:Drug Resistance; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000150:complications / Q000628:therapy*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008077:Lipoproteins, LDL / Q000097:blood*; D009404:Nephrotic Syndrome / Q000097:blood / Q000209:etiology / Q000628:therapy*; D010956:Plasmapheresis; D006435:Renal Dialysis; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D008077:Lipoproteins, LDL