Development of a Biomedical Micro/Nano Robot for Drug Delivery.
Flagellated bacteria have been utilized as potential swimming micro-robotic bodies for propulsion of spherical liposome by attaching several bacteria on their surface. Liposome as a drug delivery vehicle can contain biologically active compounds. In this work, the antibody binding technique is developed to attach bacteria to liposome's surface. Consequently, the stochastic effect of bacterial propulsion of liposome is investigated analytically and experimentally. It is shown that the mobility of liposome with bacteria was higher than that of liposome without bacteria. Experimental data matches well with statistical calculation.
Zhenhai
Z
Zhang
Zhifei
Z
Li
Wei
W
Yu
Kejie
K
Li
Zhihong
Z
Xie
D055910:Antibodies, Immobilized / Q000737:chemistry* / Q000378:metabolism; D001419:Bacteria / Q000166:cytology* / Q000378:metabolism; D018914:Cells, Immobilized / Q000166:cytology; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005407:Flagella / Q000502:physiology*; D008081:Liposomes / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation*; D012371:Robotics
D055910:Antibodies, Immobilized; D008081:Liposomes