Inside Job: Viruses Transfer cGAMP between Cells.
The DNA sensor, cyclic GMP-AMP synthase (cGAS), is essential for the detection of viral infection. In a recent issue of Science, two studies, Bridgeman et al. (2015) and Gentili et al. (2015), report a novel mechanism for propagating an antiviral signal between cells, based on the transfer of the cGAS enzymatic product, cyclic GMP-AMP (cGAMP), in viral particles.
Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Muhammet F
MF
Gulen
Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: andrea.ablasser@epfl.ch.
Andrea
A
Ablasser
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000378:metabolism*; D006561:Herpes Simplex / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D016899:Interferon-beta / Q000276:immunology*; D018146:Muromegalovirus / Q000378:metabolism*; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D015290:Second Messenger Systems; D014615:Vaccinia / Q000276:immunology*; D014616:Vaccinia virus / Q000378:metabolism*; D014771:Virion / Q000378:metabolism*
D009712:Nucleotides, Cyclic; D016899:Interferon-beta