Neural map formation and sensory coding in the vomeronasal system.
Sensory systems enable us to encode a clear representation of our environment in the nervous system by spatially organizing sensory stimuli being received. The organization of neural circuitry to form a map of sensory activation is critical for the interpretation of these sensory stimuli. In rodents, social communication relies strongly on the detection of chemosignals by the vomeronasal system, which regulates a wide array of behaviours, including mate recognition, reproduction, and aggression. The binding of these chemosignals to receptors on vomeronasal sensory neurons leads to activation of second-order neurons within glomeruli of the accessory olfactory bulb. Here, vomeronasal receptor activation by a stimulus is organized into maps of glomerular activation that represent phenotypic qualities of the stimuli detected. Genetic, electrophysiological and imaging studies have shed light on the principles underlying cell connectivity and sensory map formation in the vomeronasal system, and have revealed important differences in sensory coding between the vomeronasal and main olfactory system. In this review, we summarize the key factors and mechanisms that dictate circuit formation and sensory coding logic in the vomeronasal system, emphasizing differences with the main olfactory system. Furthermore, we discuss how detection of chemosignals by the vomeronasal system regulates social behaviour in mice, specifically aggression.
Montreal Neurological Institute, Centre for Neuronal Survival, 3801 University, Room MP105, Montréal, QC, H3A 2B4, Canada.|Department of Anatomy and Cell Biology, McGill University, Montréal, Canada.
Alexandra C
AC
Brignall
Montreal Neurological Institute, Centre for Neuronal Survival, 3801 University, Room MP105, Montréal, QC, H3A 2B4, Canada. jf.cloutier@mcgill.ca.|Department of Neurology and Neurosurgery, McGill University, Montréal, Canada. jf.cloutier@mcgill.ca.|Department of Anatomy and Cell Biology, McGill University, Montréal, Canada. jf.cloutier@mcgill.ca.
Jean-François
JF
Cloutier
D000374:Aggression; D000818:Animals; D003463:Cues; D051379:Mice; D008954:Models, Biological; D009415:Nerve Net; D009830:Olfactory Bulb / Q000502:physiology; D018034:Olfactory Receptor Neurons / Q000502:physiology; D012919:Social Behavior; D013268:Stimulation, Chemical; D019147:Vomeronasal Organ / Q000294:innervation / Q000502:physiology*
Aggression; Axonal guidance; Glomerular maps; Sensory coding; Vomeronasal system