Scholte wave generation during single tracking location shear wave elasticity imaging of engineered tissues.
The physical environment of engineered tissues can influence cellular functions that are important for tissue regeneration. Thus, there is a critical need for noninvasive technologies capable of monitoring mechanical properties of engineered tissues during fabrication and development. This work investigates the feasibility of using single tracking location shear wave elasticity imaging (STL-SWEI) for quantifying the shear moduli of tissue-mimicking phantoms and engineered tissues in tissue engineering environments. Scholte surface waves were observed when STL-SWEI was performed through a fluid standoff, and confounded shear moduli estimates leading to an underestimation of moduli in regions near the fluid-tissue interface.
Department of Biomedical Engineering, Robert B. Georgen Hall, Box 270168, University of Rochester, Rochester, New York 14627, USA.
Karla P
KP
Mercado
Department of Biomedical Engineering, Robert B. Georgen Hall, Box 270168, University of Rochester, Rochester, New York 14627, USA.
Jonathan
J
Langdon
Chester F. Carlson Center for Imaging Science, 54 Lomb Memorial Drive, Rochester Institute of Technology, Rochester, New York 14623, USA.
María
M
Helguera
Department of Biomedical Engineering, Robert B. Georgen Hall, Box 270168, University of Rochester, Rochester, New York 14627, USA.
Stephen A
SA
McAleavey
Department of Pharmacology and Physiology, 601 Elmwood Avenue, Box 711, University of Rochester, Rochester, New York 14642, USA karlapatricia.mercado@rochester.edu, jonathan_langdon@urmc.rochester.edu, helguera@cis.rit.edu, stephen.mcaleavey@rochester.edu, denise_hocking@urmc.rochester.edu, dalecki@bme.rochester.edu.
Denise C
DC
Hocking
Department of Biomedical Engineering, Robert B. Georgen Hall, Box 270168, University of Rochester, Rochester, New York 14627, USA.
Diane
D
Dalecki
D000818:Animals; D002478:Cells, Cultured; D024042:Collagen Type I; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005240:Feasibility Studies; D005347:Fibroblasts / Q000166:cytology; D005780:Gelatin; D020100:Hydrogels; D051379:Mice; D009991:Oscillometry; D019047:Phantoms, Imaging; D033081:Shear Strength; D013213:Starch; D023822:Tissue Engineering; D014160:Transducers, Pressure; D014465:Ultrasonics; D014867:Water
D024042:Collagen Type I; D020100:Hydrogels; D014867:Water; D005780:Gelatin; D013213:Starch