Tuberculosis: Challenges to Improve the Treatment.
Tuberculosis is one of the leading causes of morbidity and mortality worldwide. Current treatment has several challenges, such as multi-drug resistance, extensively drug-resistance and HIV co-infection. Problems related to patients, treatment and health care system also contribute negatively to this panel. This review summarizes the main obstacles causing in the treatment of tuberculosis and discusses several strategies to improve the treatment.
Mariana Moreira
MM
Lima
Ariane
A
Trindade
Flávia
F
Carnavalli
Aylime Castanho
AC
Bolognesi Melchior
Chung Man
CM
Chin
State University of São Paulo "Júlio de Mesquita Filho" -UNESP, School of Pharmaceutical Science, Drugs and Medicines Departament, Center of Pharmaceutical Care (NAF), Rodovia Araraquara Jaú Km, 01, 14801-902 Araraquara, SP, Brazil. santosjl@fcfar.unesp.br.
Jean Leandro
JL
Dos Santos
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*
D000995:Antitubercular Agents