The immunization with peptide 189-205, a derivative of serotonin receptor subtypes 1B, changes the sensetivity of adenylyl cyclase to hormones in the rat brain.
The aim of this work was to study the effect of multiple (during 12 months) immunization of rats with BSA-conjugated peptide 189-205 corresponding to the second extracellular loop of rat HT1BR on ACSS activity in the brain of immunized animals (group HT1BR) and its regulation by hormones.
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223, Russia.
K V
KV
Derkach
E A
EA
Shpakova
I I
II
Tarasenko
O A
OA
Zharova
A O
AO
Shpakov
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism*; D006728:Hormones / Q000494:pharmacology*; D007114:Immunization; D008297:Male; D010446:Peptide Fragments / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D044302:Receptor, Serotonin, 5-HT1B / Q000737:chemistry*; D013961:Thyroid Gland / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
D006728:Hormones; D010446:Peptide Fragments; D044302:Receptor, Serotonin, 5-HT1B; D000262:Adenylyl Cyclases