[Comparative Analysis of Subpopulations of Mesenchymal Stromal Cells of the Bone Marrow and Fetal Liver Differing in Sensitivity to 5-Fluorouracil].
It is shown that the effect of 5-fluorouracil (5-FU) on mesenchymal stromal cells (MSCs) of the bone marrow and fetal liver of the rat increases the population of cells with a reduced proliferative potential. It is shown that, in the course of passaging, the 5-FU-resistant MSCs of the bone marrow and fetal liver lose their ability to differentiate in the osteogenic direction more and less rapidly, respectively, than the 5-FU-sensitive MSCs.
O V
OV
Payushina
N N
NN
Butorina
O N
ON
Sheveleva
E I
EI
Domaratskaya
D000818:Animals; D002478:Cells, Cultured; D053595:Embryonic Stem Cells / Q000166:cytology / Q000187:drug effects*; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology*; D008099:Liver / Q000166:cytology; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects*; D010012:Osteogenesis; D051381:Rats; D017208:Rats, Wistar
D005472:Fluorouracil