Autism spectrum disorder model mice: Focus on copy number variation and epigenetics.
Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%-2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.
Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.|Graduate School of Biostudies, Kyoto University, Kyoto, 606-8501, Japan.|RIKEN Brain Science Institute, Wako, 351-0198, Japan.
Nobuhiro
N
Nakai
Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.
Susumu
S
Otsuka
Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.|RIKEN Brain Science Institute, Wako, 351-0198, Japan.
Jihwan
J
Myung
Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8553, Japan. toru.takumi@riken.jp.|RIKEN Brain Science Institute, Wako, 351-0198, Japan. toru.takumi@riken.jp.|Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, 102-0076, Japan. toru.takumi@riken.jp.
Toru
T
Takumi
D000818:Animals; D000067877:Autism Spectrum Disorder / Q000235:genetics*; D056915:DNA Copy Number Variations; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D051379:Mice; D008957:Models, Genetic
ASD model mouse; DNA methylation; copy number variations; histone modification