Translational treatment of aphasia combining neuromodulation and behavioral intervention for lexical retrieval: implications from a single case study.
BACKGROUND
Transcranial direct current stimulation (tDCS), a non-invasive method of brain stimulation, is an adjunctive research-therapy for aphasia. The concept supporting translational application of tDCS is that brain plasticity, facilitated by language intervention, can be enhanced by non-invasive brain stimulation. This study combined tDCS with an ecologically focused behavioral approach that involved training nouns and verbs in sentences.


METHODS



METHODS
A 43-year-old, right-handed male with fluent-anomic aphasia who sustained a single-left-hemisphere-temporal-parietal stroke was recruited.


METHODS
Instrumentation included the Soterix Medical 1 × 1 Device. Anodal tDCS was applied over Broca's area. Behavioral materials included: sentence production, naming in the sentence context, and implementation of a social-conversational-discourse treatment.


METHODS
The independent variable of this crossover case-study was tDCS, and the dependent variables were language and quality-of-life measures. In each session the subject received language treatment with the first 20 minutes additionally including tDCS.


RESULTS
Performance in naming nouns and verbs in single words and sentences were obtained. Verb production in the sentence context increased after active anodal tDCS and speech-language treatment.


CONCLUSIONS
Aphasia treatment that involves naming in the sentence context in conjunction with translational application of tDCS may be a promising approach for language-recovery post stroke.
Speech-Language Pathology and Audiology, Hunter College New York, NY, USA ; Speech-Language-Hearing Sciences, Graduate Center, City University of New York New York, NY, USA.
Elizabeth E
EE
Galletta
Speech-Language Pathology and Audiology, Hunter College New York, NY, USA ; Speech-Language-Hearing Sciences, Graduate Center, City University of New York New York, NY, USA.
Amy
A
Vogel-Eyny
aphasia; lexical retrieval; neuromodulation; tDCS; treatment