Potential use of OCT-based microangiography in clinical dermatology.
BACKGROUND
Optical coherence tomography (OCT) is a revolutionary imaging technique used commonly in ophthalmology, and on the way to become clinically viable alternative in dermatology due to its capability of acquiring histopathology level details of in vivo tissue, non-invasively. In this study, we demonstrate the capabilities of OCT-based microangiography in detecting high resolution, three-dimensional structural, and microvascular features of in vivo human skin with various conditions.


METHODS
A swept-source OCT system that operates on a central wavelength of 1310 nm with an A-line rate of 100 kHz is used in this study. We apply optical microangiography (OMAG) technique to visualize the structural and microvascular changes in tissue.


RESULTS
OMAG images provide detailed visualization of functional microvasculature of healthy human skin from cheek and forehead areas, abnormal skin conditions from face, chest and belly. Moreover, OMAG is capable of monitoring the progress of wound healing on human skin from arm, delivering unprecedented detail of microstructural and microvascular information during longitudinal wound healing process.


CONCLUSIONS
The presented results promise the clinical use of OCT angiography, aiming to treat prevalent cutaneous diseases, by detecting blood perfusion, and structural changes within human skin, in vivo.
Department of Bioengineering, University of Washington, Seattle, WA, USA.|Department of Electrical Engineering, University of Washington, Seattle, WA, USA.
Utku
U
Baran
Department of Bioengineering, University of Washington, Seattle, WA, USA.
Woo June
WJ
Choi
Department of Bioengineering, University of Washington, Seattle, WA, USA.
Ruikang K
RK
Wang
D000792:Angiography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation; D055806:Microvessels / Q000000981:diagnostic imaging* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012871:Skin Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*
acne; nevus; optical coherence tomography; optical microangiography; wound healing