Allograft inflammatory factor-1 in grass carp (Ctenopharynogodon idella): Expression and response to cadmium exposure.
Allograft Inflammatory Factor-1 (AIF-1) is an inflammation responsive protein that is mainly produced by immunocytes. As a pro-inflammatory cytokine, AIF-1 is a key moderator in host immune defense reaction. However, the inflammatory properties of AIF-1 in freshwater fish still hasn't been clearly elucidated. In the present study, AIF-1 was identified from grass carp (Ctenopharynogodon idella). It's transcript was found in all examined tissues including brain, spleen, kidney, liver, heart, while a relative low level in red muscle, gill, thymus, white muscle, intestine and fin. Furthermore, AIF-1 transcription and expression level decreased in spleen and didn't change a lot in kidney with cadmium induction, respectively. The result indicated that grass carp AIF-1 might be involved in cadmium-induced stress.
College of Life Science and Technology, Southwest University for Nationalities, Chengdu, 610041, PR China.
Yanying
Y
Zhao
Reproductive Laboratory, Chengdu Woman Children Central Hospital, Chengdu, PR China; Health Ministry Key Laboratory of Chronobiology, Pre-clinic and Forensic Medical School, Sichuan University, Chengdu, PR China.
Ruiwen
R
Li
College of Life Science and Technology, Southwest University for Nationalities, Chengdu, 610041, PR China. Electronic address: yaqlin@163.com.
Yaqiu
Y
Lin
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015153:Blotting, Western / Q000662:veterinary; D002104:Cadmium / Q000633:toxicity*; D002347:Carps / Q000235:genetics* / Q000378:metabolism; D016207:Cytokines / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D029941:Fish Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D009928:Organ Specificity; D010802:Phylogeny; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D016207:Cytokines; D029941:Fish Proteins; D014874:Water Pollutants, Chemical; D002104:Cadmium
AIF-1; Allograft inflammatory factor-1; Cadmium; Grass carp