PRO12ALA POLYMORPHISM ASSOCIATION OF PPAR-γ GENE WITH BIOCHEMICAL PARAMETERS OF THE BLOOD IN PATIENTS WITH CHRONIC DIFFUSE LIVER DISEASES.
The connection of Pro12Ala polymorphism of PPAR-γ gene with blood biochemical parameters in patients with nonalcoholic fatty liver disease (NAFLD) and nonviral chronic hepatitis (CH) were analyzed. The frequency of incidence of minor Ala-allele of PPAR-γ gene in those patients was not found to be significantly different from that in healthy individuals. Aspartate aminotransferase activity in NAFLD patients, Ala-allele carriers, was significantly higher on 55,5% (p=0,007) than in patients with Pro/Pro-genotype. At the same time, alanine aminotransferase activity in patients with Ala-allele was significantly higher on 80,0% (p=0,03) than in patients with Pro/Pro -genotype PPAR-γ gene. In this cohort of patients with minor Ala-allele high gamma-glutamyltransferase activity was diagnosed, which in 2,1 times (p=0,04) prevailed that in patients, Pro/Pro-genotype carriers. Patients with CH showed no significant association between Pro12Ala polymorphism of PPAR-γ gene and activity of biochemical markers of pathological process in the liver.
Bukovinian State Medical University, Chernivtsi, Ukraine.
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Prysyazhnyuk
D000410:Alanine Transaminase / Q000097:blood; D000483:Alleles; D001219:Aspartate Aminotransferases / Q000097:blood; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006521:Hepatitis, Chronic / Q000097:blood / Q000235:genetics* / Q000473:pathology; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000235:genetics* / Q000473:pathology; D047495:PPAR gamma / Q000235:genetics*
D047495:PPAR gamma; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase