Rerouting Resistance: Escaping Restriction Using Alternative Cellular Pathways.
Pathogens, essentially utilizing host machinery for replication, can adapt to exploit cellular redundancies to substitute favored host-pathogen interactions when blocked, leading to a new type of stubborn resistance. Resa-Infante et al. reveal one such 'rerouting-resistance' acquired by the influenza virus when a vital host factor was deleted in mice.
Faculty of Biology, Technion - Israel Institute of Technology, Haifa 320003, Israel.
Ailie
A
Marx
Faculty of Biology, Technion - Israel Institute of Technology, Haifa 320003, Israel. Electronic address: alian@tx.technion.ac.il.
Akram
A
Alian
D000818:Animals; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000472:pathogenicity*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D037521:Virulence Factors / Q000235:genetics*; D028901:alpha Karyopherins / Q000235:genetics*
D037521:Virulence Factors; D028901:alpha Karyopherins
Alternative Pathway; Host-Pathogen Interaction; Rerouting; Resistance