ESAM predicts cardiovascular mortality in diabetic hemodialysis patients.
OBJECTIVE
To assess endothelial cell selective adhesion molecule (ESAM) as predictor of cardiovascular mortality in diabetic dialysis patients (DDPs).


METHODS
ESAM, clinical and laboratory parameters were assessed in 73 DDP. Cardiovascular mortality was recorded in a 2 years' prospective observational study.


RESULTS
Baseline ESAM was 17.1 (10.05-24.8) ng/ml and was correlated to phosphate (r = -0.42, p = 0.008), parathormone (r = -0.36, p = 0.048), albumin (r = -0.24, p = 0.048). ESAM significantly predicted cardiovascular death in univariate [HR = 1.03, 95% CI (1.006-1.054), p = 0.01] and multivariate [HR = 1.034, 95% CI (1.003-1.066), p = 0.03] Cox analysis. Time to cardiovascular death was shorter for patients with ESAM >12.44 ng/ml, p = 0.0045.


CONCLUSIONS
ESAM is an independent predictor of cardiovascular mortality in DDP.
a Department of Nephrology and.
Ina Maria
IM
Kacso
Alina Ramona
AR
Potra
Cosmina Ioana
CI
Bondor
Diana
D
Moldovan
Crina
C
Rusu
Ioan Mihai
IM
Patiu
Simona
S
Racasan
Remus
R
Orasan
Raluca
R
Moldovan
Bogdan
B
Ghigolea
Dan
D
Vladutiu
Costel
C
Spanu
Cristian
C
Nita
Anca
A
Rusu
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000150:complications / Q000401:mortality*; D015815:Cell Adhesion Molecules / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D015415:Biomarkers; D015815:Cell Adhesion Molecules; C568779:ESAM protein, human
Adhesion molecule; atheroscelorsis; endothelium; mineral metabolism