Cutaneous histiocytic sarcoma with E-cadherin expression in a Pembroke Welsh Corgi dog.
An 11-year-old male neutered Pembroke Welsh Corgi dog displayed a mass measuring 7.5 cm × 6.6 cm × 1.6 cm in the skin. Neoplastic tissue was nonencapsulated, and the neoplastic cells showed infiltrative growth into the surrounding tissue on microscopic examination. The neoplastic tissue was mainly located from the dermis to the subcutis. Epidermotropism of neoplastic cells was not observed. The tissue was composed of irregular, solid nests of round to polygonal cells. Nests were separated by fine fibrovascular stroma. Mitotic index was high (7.90 ± 0.38 per high power field) and extensive necrosis was observed in the neoplastic tissue. Vascular invasion was often observed in the neoplastic tissue. Neoplastic cells were positive for vimentin, HLA-DR antigen, Iba1, CD18, and E-cadherin, but cells did not express cytokeratin, S100, CD20, CD79α, CD3, MUM-1, lambda light chain, kappa light chain, lysozyme, CD204, or CD11d by immunohistochemistry. Electron microscopic analysis revealed dendrites on these cells. From the above-mentioned findings, the tumor was diagnosed as a cutaneous histiocytic sarcoma with E-cadherin expression. It is possible that neoplastic cells in the present case were derived from cutaneous Langerhans cell. To our knowledge, cutaneous histiocytic sarcoma with E-cadherin expression in domestic animals has not been previously diagnosed in domestic animals.
Department of Veterinary Laboratory Medicine (Hirako, Sugiyama, Takeuchi), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanVeterinary Pathology (Sakurai, Morita), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanDepartment of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan (Ozaki)Department of Veterinary Pathology, School of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (Sakai)Department of Pathology, Microbiology, Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA (Moore).
Ayano
A
Hirako
Department of Veterinary Laboratory Medicine (Hirako, Sugiyama, Takeuchi), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanVeterinary Pathology (Sakurai, Morita), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanDepartment of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan (Ozaki)Department of Veterinary Pathology, School of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (Sakai)Department of Pathology, Microbiology, Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA (Moore) sugiyama@muses.tottori-u.ac.jp.
Akihiko
A
Sugiyama
Department of Veterinary Laboratory Medicine (Hirako, Sugiyama, Takeuchi), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanVeterinary Pathology (Sakurai, Morita), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanDepartment of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan (Ozaki)Department of Veterinary Pathology, School of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (Sakai)Department of Pathology, Microbiology, Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA (Moore).
Masashi
M
Sakurai
Department of Veterinary Laboratory Medicine (Hirako, Sugiyama, Takeuchi), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanVeterinary Pathology (Sakurai, Morita), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanDepartment of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan (Ozaki)Department of Veterinary Pathology, School of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (Sakai)Department of Pathology, Microbiology, Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA (Moore).
Kiyokazu
K
Ozaki
Department of Veterinary Laboratory Medicine (Hirako, Sugiyama, Takeuchi), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanVeterinary Pathology (Sakurai, Morita), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanDepartment of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan (Ozaki)Department of Veterinary Pathology, School of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (Sakai)Department of Pathology, Microbiology, Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA (Moore).
Hiroki
H
Sakai
Department of Veterinary Laboratory Medicine (Hirako, Sugiyama, Takeuchi), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanVeterinary Pathology (Sakurai, Morita), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanDepartment of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan (Ozaki)Department of Veterinary Pathology, School of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (Sakai)Department of Pathology, Microbiology, Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA (Moore).
Takashi
T
Takeuchi
Department of Veterinary Laboratory Medicine (Hirako, Sugiyama, Takeuchi), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanVeterinary Pathology (Sakurai, Morita), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanDepartment of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan (Ozaki)Department of Veterinary Pathology, School of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (Sakai)Department of Pathology, Microbiology, Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA (Moore).
Takehito
T
Morita
Department of Veterinary Laboratory Medicine (Hirako, Sugiyama, Takeuchi), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanVeterinary Pathology (Sakurai, Morita), School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, JapanDepartment of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan (Ozaki)Department of Veterinary Pathology, School of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (Sakai)Department of Pathology, Microbiology, Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA (Moore).
Peter F
PF
Moore
D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D054747:Histiocytic Sarcoma / Q000175:diagnosis / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D010375:Pedigree; D012878:Skin Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D013909:Thorax
D015820:Cadherins
Dogs; E-cadherin; histiocytic sarcoma; skin