Actin filaments as the fast pathways for calcium ions involved in auditory processes.
We investigated the polyelectrolyte properties of actin filaments which are in interaction with myosin motors, basic participants in mechano-electrical transduction in the stereocilia of the inner ear. Here, we elaborated a model in which actin filaments play the role of guides or pathways for localized flow of calcium ions. It is well recognized that calcium ions are implicated in tuning of actin-myosin cross-bridge interaction, which controls the mechanical property of hair bundle. Actin filaments enable much more efficient delivery of calcium ions and faster mechanism for their distribution within the stereocilia. With this model we were able to semiquantitatively explain experimental evidences regarding the way of how calcium ions tune the mechanosensitivity of hair cells.
Faculty of Technical Sciences, University of Novi Sad, Trg Dositeja Obradovica 6, 21000, Novi Sad, Serbia.
Miljko V
MV
Sataric
Dalibor L
DL
Sekulic
Bogdan M
BM
Sataric
D008841:Actin Cytoskeleton / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D006198:Hair Cells, Auditory / Q000502:physiology; D006309:Hearing / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D059547:Stereocilia / Q000502:physiology
D015220:Calcium Channels; D002118:Calcium