Results of surgical treatment of primary lung cancer with synchronous brain metastases.
BACKGROUND
The surgical treatment of non-small cell lung cancer (NSCLC) with synchronous brain matastases is more effective than other therapeutic options, but this management is still controversial.


OBJECTIVE
The aim of the study was to evaluate the survival of patients after pulmonary resection NSCLC preceded by resection of brain metastases.


METHODS
From 2007 to 2012, 645 patients underwent pulmonary resection for NSCLC at our department. In 25 of them (3.87%) thoracic surgery was preceded by resection of a single brain metastasis of NSCLC and a PET CT scan. No signs of nodal involvement or distant metastases were detected.


RESULTS
The group consisted of 18 men (72%) and 7 women (28%). Average age was 57.62 years (46-70). In all cases, whole brain radiotherapy (5 × 4 Gy) was performed. The average interval between excision of brain metastasis and lung resection was 31.4 days (27-41). Pneumonectomy was performed in 1, lobectomy/bilobectomy in 17 and wedge resection in 7 cases. Pathological stage N0 was diagnosed in 17, N1 in 5 and N2 in 3 patients. Average survival was 18.68 months (4-74). Survival at 1, 2 and 5 years was 64%, 28% and 28% respectively. Average disease-free survival was 17.52 months. Histological type (p = 0.57) and G (p = 0.82) have no influence on survival. All the patients with hilar lymph node involvement died within 26 months and with mediastinal one within 12 months.


CONCLUSIONS
Surgical treatment of patients with NSCLC with synchronous brain metastases may prove beneficial in selected patients after excluding other distant metastases and lymph node involvement.
Department of Thoracic Surgery and Tumours, Faculty of Medicine, Nicolaus Copernicus University in Torun, Poland ; Department of Thoracic Surgery and Tumours, Oncology Centre, Bydgoszcz, Poland.
Mariusz Jan
MJ
Bella
Department of Thoracic Surgery and Tumours, Faculty of Medicine, Nicolaus Copernicus University in Torun, Poland ; Department of Thoracic Surgery and Tumours, Oncology Centre, Bydgoszcz, Poland.
Janusz
J
Kowalewski
Department of Thoracic Surgery and Tumours, Oncology Centre, Bydgoszcz, Poland.
Maciej
M
Dancewicz
Department of Thoracic Surgery and Tumours, Oncology Centre, Bydgoszcz, Poland.
Przemysław
P
Bławat
Department of Thoracic Surgery and Tumours, Oncology Centre, Bydgoszcz, Poland.
Tomasz Jarosław
TJ
Szczęsny
Department of Thoracic Surgery and Tumours, Faculty of Medicine, Nicolaus Copernicus University in Torun, Poland ; Department of Thoracic Surgery and Tumours, Oncology Centre, Bydgoszcz, Poland.
Aleksandra
A
Chrząstek
Department of Thoracic Surgery and Tumours, Faculty of Medicine, Nicolaus Copernicus University in Torun, Poland ; Department of Thoracic Surgery and Tumours, Oncology Centre, Bydgoszcz, Poland.
Paweł
P
Wnuk
brain metastases; lung cancer