Acute and Cytotoxicity Studies of Aqueous and Ethanolic Leaf Extracts of Chromolaena odorata.
Chromolaena odorata, a commonly used traditional remedy for different ailments, believed to be quite safe in terms of toxicity was evaluated for acute toxicity and cytotoxic potentials. Acute toxicity was done on albino Wistar rats using the Lorke method while brine shrimps were used to test for cytotoxicity. The results showed that the estimated LD50 for the aqueous and ethanolic extracts was 2154 and > 5000 mg kg(-1) body weight, respectively. Cytotoxicity to brine shrimps showed LC50 values of 324 and 392 ppm for aqueous and ethanolic extracts, respectively. These results indicate the relative non toxic nature of Chromolaena odorata extracts.
R N
RN
Asomugha
A N
AN
Ezejiofor
P N
PN
Okafor
I I
II
Ijeh
D000818:Animals; D001156:Artemia / Q000187:drug effects; D036604:Chromolaena / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry*; D007928:Lethal Dose 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity*; D018515:Plant Leaves; D010946:Plants, Medicinal; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000431:Ethanol