Domino Reactions Containing Different Types of Heck Reactions for Selective 3,3- and 1,3-Diarylations of Propenol with Aryl Halides by Triple Catalysis.
A new domino Heck-isomerization/Saegusa/Heck reaction of propenol with aryl iodides has been developed for the synthesis of 3,3-diaryl propenals by triple transition-metal catalysis. Moreover, we also developed the domino Heck-isomerization/Heck-type reaction of propenol with aryl iodides for the synthesis of 1,3-diaryl propanones by double transition-metal catalysis and the mediation of secondary amine or triple transition metal catalysis and aminocatalysis.
Department of Chemistry, Zhejiang University , Hangzhou 310028, China.
Zhi-Qiang
ZQ
Zhu
Jiangsu Coben Pharmaceutical Co., Ltd , Qidong, Jiangsu 310004, P. R. China.
Jian-Shi
JS
He
College of Pharmaceutical Sciences, Qiqihar Medical University , Qiqihar 161006, P. R. China.
Hai-Jun
HJ
Wang
Department of Chemistry, Zhejiang University , Hangzhou 310028, China.|State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin 300071, P. R. China.
Zhi-Zhen
ZZ
Huang