Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents.
The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed to swell up when exposed to moisture, facilitating release of the NPs via diffusion across the matrix. CSM is intended to be administered topically and locally to mucosal tissues, with its initial indication being oral cancer (OC). Currently, intravenous (IV) administered CDDP is the gold standard chemotherapeutic agent used in the treatment of OC. However, its clinical use has been limited by its renal and hemotoxicity profile. We aim to locally administer CDDP via encapsulation in CS NPs and deliver them directly to the oral cavity with CSM. It is hypothesized that such a delivery device will greatly reduce any systemic toxicity and increase antitumor efficacy. This paper describes the methods for developing CSM and maintaining the integrity of CDDP NPs embedded in the CSM.
Massachusetts Institute of Technology , Cambridge, MA 02139.
Manijeh
M
Goldberg
Massachusetts Institute of Technology , Cambridge, MA 02139.
Aaron
A
Manzi
Massachusetts Institute of Technology , Cambridge, MA 02139.
Erkin
E
Aydin
Massachusetts Institute of Technology , Cambridge, MA 02139.
Gurtej
G
Singh
Massachusetts Institute of Technology , Cambridge, MA 02139.
Payam
P
Khoshkenar
Massachusetts Institute of Technology , Cambridge, MA 02139.
Amritpreet
A
Birdi
Massachusetts Institute of Technology , Cambridge, MA 02139.
Brandon
B
LaPorte
Massachusetts Institute of Technology , Cambridge, MA 02139.
Alejandro
A
Krauskopf
Wellesley College , Department of Biology, Wellesley, MA 02481.
Geralle
G
Powell
University of Massachusetts Lowell , Department of Mechanical Engineering, Lowell, MA 01854.
Julie
J
Chen
Massachusetts Institute of Technology , Cambridge, MA 02139.
Robert
R
Langer
biocompatible; biodegradable; chemotherapy; chitosan; cisplatin; drug; embedding; local; matrix; mucoadhesive; mucosa; nanoparticles; oral cancer; permeation; platform; polymeric; release; safe; sponge; topical; transmucosal