Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome.
BACKGROUND
Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes.


OBJECTIVE
Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran.


METHODS
In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples.


RESULTS
The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women.


CONCLUSIONS
These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.
Department of Midwifery, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Mahtab
M
Moti
Faculty of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Leila
L
Amini
Department of Biology, College of Basic Sciences, Karaj Branch, Islamic Azad University, Alborz, Iran.
Soheila Sadat
SS
Mirhoseini Ardakani
Department of Biology, College of Basic Sciences, Karaj Branch, Islamic Azad University, Alborz, Iran.
Sara
S
Kamalzadeh
Department of Immunology, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Masoomeh
M
Masoomikarimi
Department of Biochemistry, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Moslem
M
Jafarisani
AOPP; Antioxidant; CRP; Infertility; Polycystic ovary syndrome