Uterine Angiosarcoma: A Case Report and Literature Review.
Uterine angiosarcoma is a rare, extremely malignant vascular tumor. Here, we report a case of giant uterine angiosarcoma in a 56-yr-old woman. The tumor was diagnosed as an epithelioid uterine angiosarcoma based on histopathologic findings. The tumor cells showed vascular differentiation; they were positive for the vascular endothelial markers CD31, CD34, and was negative for lymphatic endothelial marker D2-40. In addition, the tumor cells showed overexpression of cell-cycle regulatory protein cyclin D1 and were positive for epithelial-mesenchymal transition marker vimentin. Although it was reported previously that there was breakage in YWHAE, NUTM2A (FAM22A), and NUTM2B (FAM22B) in a case of uterine angiosarcoma, no breakage in these loci was detected by fluorescence in situ hybridization in the present case.
The Cancer Institute (Y.Liu, Y.Li)Department of Gynaecology and Obsterics (S.G.)Department of Pathology (L.W.), Tangshan People's Hospital, Tangshan, Hebei, ChinaDivision of Pathology (S.S.), Iwata City Hospital, Okubo, IwataDepartment of Tumor Pathology (H.S.), Hamamatsu University School of Medicine, Handayama, Higashi Ward, Hamamatsu, Shizuoka Prefecture, Japan.
Yankun
Y
Liu
Shuhong
S
Guo
Lei
L
Wang
Shioto
S
Suzuki
Haruhiko
H
Sugimura
Yufeng
Y
Li
D014408:Biomarkers, Tumor / Q000032:analysis*; D018797:Cell Cycle Proteins / Q000235:genetics; D004730:Endothelium, Vascular / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014599:Uterus / Q000473:pathology; D014746:Vimentin / Q000235:genetics
D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D014746:Vimentin