Treatment preferences and outcome in male hypogonadotropic hypogonadism: an Indian perspective.
This retrospective study assessed treatment preferences and outcome with testosterone or HCG / HCG-FSH combination in Indian male idiopathic hypogonadotropic hypogonadism (IHH) subjects (n = 31) above 18 years of age. 38.7% of IHH study subjects had no fertility plans and chose 3 monthly intramuscular testosterone undecanoate. 73.7% of subjects with fertility plans chose human chorionic gonadotropin (HCG) alone due to cost considerations. Spermatogenesis occurred in 21.4% on HCG alone and 60% of subjects on HCG with follicle-stimulating hormone (FSH) combination. Treatment failure is higher than published Western rates. FSH and HCG combination regimen is costly but superior to HCG alone. However, treatment failure still persists, suggesting unknown testicular defect in IHH.
KPC Medical College, Kolkata, India.
D
D
Sanyal
Ramakrishna Mission Seva Prathisthan, Kolkata, India.
S
S
Chatterjee
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000191:economics; D016527:Drug Costs; D004359:Drug Therapy, Combination / Q000191:economics; D005298:Fertility / Q000187:drug effects; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000191:economics; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D007194:India; D008297:Male; D057240:Patient Preference; D012189:Retrospective Studies; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000473:pathology; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000191:economics; D016896:Treatment Outcome; D055815:Young Adult
D006063:Chorionic Gonadotropin; D013739:Testosterone; D005640:Follicle Stimulating Hormone; C010792:testosterone undecanoate
FSH; HCG; IHH; testosterone