Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy.
BACKGROUND
To report functional and high-resolution retinal imaging abnormalities, including adaptive optics (AO) throughout the course of acute macular neuroretinopathy (AMNR).


METHODS
Two female patients (four eyes) with a diagnosis of AMNR were observed at the Clinical Investigation Center, CHNO des Quinze-Vingts, Paris, France. The patients underwent detailed ophthalmic examination including best-corrected visual acuity, slit-lamp examination, kinetic and static perimetry, full-field and multifocal electroretinogram, infrared reflectance, autofluorescence imaging and spectral-domain optical coherence tomography (SD-OCT) and AO fundus imaging at presentation and during follow-up.


RESULTS
Both cases showed concomitant loss of integrity of the outer retinal structures on SD-OCT, and marked abnormalities on AO imaging with disruption of the visibility of the cone mosaic. In the first case, photoreceptor damage was seen to progress during several weeks before healing. In both cases, there were persistent morphological abnormalities of photoreceptors 1 year after onset.


CONCLUSIONS
This study further highlights the value of AO fundus imaging to facilitate detection, mapping, and monitoring of damage to the cone outer segments during AMNR. In particular, residual damage to the cone mosaic can be precisely documented.
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France. isabelle.audo@inserm.fr.|INSERM, U968, Paris, 75012, France. isabelle.audo@inserm.fr.|Institut de la Vision, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Paris, 75012, France. isabelle.audo@inserm.fr.|CNRS, UMR_7210, Paris, 75012, France. isabelle.audo@inserm.fr.|Département de Génétique, Curie/CHNO des Quinze-Vingts, Centre de Recherche Institut de la Vision, UMR S 968 Inserm / Université Pierre et Marie, 17, rue Moreau, 75012, Paris, France. isabelle.audo@inserm.fr.
Isabelle
I
Audo
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France.|Ophthalmology, Nippon Medical University, Chiba Hokusoh Hospital, Inzai, Japan.
Kiyoko
K
Gocho
Institut Supérieur d'Electronique de Paris, Paris, France.
Florence
F
Rossant
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France.|INSERM, U968, Paris, 75012, France.|Institut de la Vision, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Paris, 75012, France.|CNRS, UMR_7210, Paris, 75012, France.
Saddek
S
Mohand-Saïd
Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Kevin
K
Loquin
Telecom Paris Tech, CNRS LTCI, Paris, France.
Isabelle
I
Bloch
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France.|INSERM, U968, Paris, 75012, France.|Institut de la Vision, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Paris, 75012, France.|CNRS, UMR_7210, Paris, 75012, France.|Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.|Académie des Sciences-Institut de France, Paris, 75006, France.
José-Alain
JA
Sahel
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France.|INSERM, U968, Paris, 75012, France.|Institut de la Vision, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Paris, 75012, France.|CNRS, UMR_7210, Paris, 75012, France.
Michel
M
Paques
D000208:Acute Disease; D000293:Adolescent; D003952:Diagnostic Imaging; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D012164:Retinal Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D012607:Scotoma / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
Acute macular neuroretinopathy; Adaptive optics; High-resolution retinal imaging; Multimodal retinal imaging; SD-OCT