Angiotensin Receptor Blocker Losartan Inhibits Spontaneous Motility of Isolated Human Ureter.
OBJECTIVE
Ureteral motility is essential for elimination of intraluminal stones, and it may be adversely affected by cardiovascular drugs that a patient is taking chronically. The aim of our study was to test whether ACE inhibitors and an angiotensin receptor blocker may influence spontaneous contractions of isolated human ureter.


METHODS
Both phasic and tonic contractions of the isolated ureteral segments taken from 10 patients were measured as changes of the longitudinal tension or pressure recordings. Captopril, enalapril and losartan were separately added to the organ baths cumulatively.


RESULTS
While enalapril (2.7 × 10-7-3.9 × 10-4M) and captopril (6.1 × 10-7-2.7 × 10-3M) did not affect either spontaneous activity or tone of isolated ureteral segments, losartan (2.9 × 10-7-4.2 × 10-4M) caused concentration-dependent inhibition of spontaneous contractions of the segments (50 % effective concentration (EC50) = 13.46 ± 1.80 × 10-6M; F = 10.72, r = 0.79, p < 0.001).


CONCLUSIONS
Due to differences in molecular mechanism of action, angiotensin receptor blocker losartan does and ACE inhibitors captopril and enalapril do not inhibit spontaneous contractions of isolated human ureter.
Faculty of Medical Sciences, University of Kragujevac, and Clinical Center, ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia. slobnera@gmail.com.
Slobodan M
http://orcid.org/0000-0002-1519-8828
SM
Jankovic
Faculty of Medical Sciences, University of Kragujevac, and Clinical Center, ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia.
Dobrivoje
D
Stojadinovic
Faculty of Medical Sciences, University of Kragujevac, and Clinical Center, ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia.
Miroslav
M
Stojadinovic
Faculty of Medical Sciences, University of Kragujevac, and Clinical Center, ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia.
Snezana V
SV
Jankovic
Faculty of Medical Sciences, University of Kragujevac, and Clinical Center, ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia.
Janko M
JM
Djuric
Faculty of Medical Sciences, University of Kragujevac, and Clinical Center, ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia.
Isidora
I
Stojic
Faculty of Medical Sciences, University of Kragujevac, and Clinical Center, ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia.
Marina
M
Kostic
D000368:Aged; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology; D002292:Carcinoma, Renal Cell / Q000503:physiopathology / Q000601:surgery; D004656:Enalapril / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009994:Osmolar Concentration; D014513:Ureter / Q000187:drug effects* / Q000503:physiopathology
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004656:Enalapril; D002216:Captopril; D019808:Losartan