Elastic Membrane Deformations Govern Interleaflet Coupling of Lipid-Ordered Domains.
The mechanism responsible for domain registration in two membrane leaflets has thus far remained enigmatic. Using continuum elasticity theory, we show that minimum line tension is achieved along the rim between thicker (ordered) and thinner (disordered) domains by shifting the rims in opposing leaflets by a few nanometers relative to each other. Increasing surface tension yields an increase in line tension, resulting in larger domains. Because domain registration is driven by lipid deformation energy, it does not require special lipid components or interactions at the membrane midplane.
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31/5 Leninskiy prospekt, Moscow 119071, Russia.|National University of Science and Technology "MISiS", 4 Leninskiy prospekt, Moscow 119049, Russia.
Timur R
TR
Galimzyanov
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31/5 Leninskiy prospekt, Moscow 119071, Russia.
Rodion J
RJ
Molotkovsky
M.V. Lomonosov Moscow State University, 1 Leninskie Gory, Moscow 119991, Russia.|Federal Research Clinical Center of the Specialized Types of Health Care and Medical Technologies FMBA of Russia, 28 Orekhovyi bulvar, Moscow 115692, Russia.
Marine E
ME
Bozdaganyan
Rush University Medical Center, 1750 W. Harrison Street, Chicago, Illinois 60612, USA.
Fredric S
FS
Cohen
Institute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40-42, Linz 4020, Austria.
Peter
P
Pohl
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31/5 Leninskiy prospekt, Moscow 119071, Russia.|National University of Science and Technology "MISiS", 4 Leninskiy prospekt, Moscow 119049, Russia.
Sergey A
SA
Akimov
D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D002784:Cholesterol / Q000737:chemistry / Q000378:metabolism; D004548:Elasticity; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D008956:Models, Chemical; D010713:Phosphatidylcholines / Q000737:chemistry / Q000378:metabolism; D013500:Surface Tension; D013816:Thermodynamics
D008563:Membrane Lipids; D010713:Phosphatidylcholines; D002784:Cholesterol