Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population.
Alopecia areata (AA) is a common disease, which causes hair loss in humans. AA has a genetically complex inheritance. This study investigated the possible correlations between single nucleotide polymorphisms (SNPs) in the promoter regions of the chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) genes and the development of AA in the Korean population. Two hundred and thirty-five AA patients and 240 control subjects were recruited. The specific SNPs occurring in the promoter regions of the CXCL1 and CXCL2 genes (rs3117604, -429C/T and rs3806792, -264T/C, respectively) were genotyped. All data obtained was evaluated using the SNPStats, SPSS 18.0, and the Haploview v.4.2 software platforms. The Odd's ratios (OR), 95% confidence intervals (CI), and P values were calculated using multiple logistic regression models. Analyses of the genetic sequences obtained revealed a significant correlation between the two SNPs and the development of AA (rs3117604, P = 0.0009 in co-dominant model 1, P = 0.01 in co-dominant model 2, P = 0.004 in the dominant model, P = 0.005 in the log-additive model, P = 0.012 in allele distribution; rs3806792, P = 0.036 in co-dominant model 2, P = 0.0046 in the log-additive model). The TT and CC haplotypes were also observed to show a significant association with increased risk of AA (TT haplotype, P = 0.0018; CC haplotype, P = 0.0349). Our data suggests that the CXCL1 and CXCL2 genes may be associated with AA susceptibility.
Kohwang Medical Research Institute, College of Medicine, Seoul, Republic of Korea.
S K
SK
Kim
Kohwang Medical Research Institute, College of Medicine, Seoul, Republic of Korea.
J-H
JH
Chung
Kohwang Medical Research Institute, College of Medicine, Seoul, Republic of Korea.
H J
HJ
Park
Kohwang Medical Research Institute, College of Medicine, Seoul, Republic of Korea.
S W
SW
Kang
Department of Biochemistry and Molecular Biology, College of Medicine, Seoul, Republic of Korea.
D-J
DJ
Lim
Department of Biochemistry and Molecular Biology, College of Medicine, Seoul, Republic of Korea.
S H
SH
Byun
Department of Biochemistry and Molecular Biology, College of Medicine, Seoul, Republic of Korea.
D G
DG
Baek
Department of Biochemistry and Molecular Biology, College of Medicine, Seoul, Republic of Korea.
H Y
HY
Ko
Department of Dermatology, Kyung Hee University, College of Medicine, Seoul, Republic of Korea.
B-L
BL
Lew
Department of Dermatology, Kyung Hee University, College of Medicine, Seoul, Republic of Korea.
H H
HH
Baik
W-Y
WY
Sim
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000506:Alopecia Areata / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D054360:Chemokine CXCL1 / Q000235:genetics*; D054426:Chemokine CXCL2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D056910:Republic of Korea / Q000453:epidemiology; D012306:Risk; D055815:Young Adult
D054360:Chemokine CXCL1; D054426:Chemokine CXCL2