Sleep Quality Effects Recovery After Total Knee Arthroplasty (TKA)--A Randomized, Double-Blind, Controlled Study.
This study examined the effects of sleep quality on early recovery after total knee arthroplasty. A total of 148 patients were randomized 1:1 to receive either zolpidem or placebo for 2 weeks. VAS pain scores (rest, ambulation and night), range of motion (ROM), total amount of opioid analgesics and antiemetics taken, postoperative nausea and vomiting (PONV), sleep efficacy and satisfaction were recorded. It was found that patients taking zolpidem achieved greater improvement in quality of life and reported better satisfaction. Patients in the intervention group had lower pain score and took less antiemetics. Moreover, a significant correlation between sleep quality and ROM was detected. These results demonstrated that improved sleep quality is beneficial to patients' post-TKA recovery.
Department of Orthopedics, Chinese PLA 252 Hospital, Baoding, Hebei, China.
Long
L
Gong
Department of Orthopedics, Chinese PLA 252 Hospital, Baoding, Hebei, China.
ZhenHu
Z
Wang
School of Basic Medical Science, Fudan University, Shanghai, China.
Dong
D
Fan
D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000932:Antiemetics / Q000008:administration & dosage; D019645:Arthroplasty, Replacement, Knee; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology / Q000627:therapeutic use*; D007211:Indoles / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use*; D011788:Quality of Life; D016059:Range of Motion, Articular / Q000187:drug effects; D020127:Recovery of Function / Q000187:drug effects*; D012890:Sleep; D000077526:Tropisetron; D000077334:Zolpidem
D000701:Analgesics, Opioid; D000932:Antiemetics; D006993:Hypnotics and Sedatives; D007211:Indoles; D011725:Pyridines; D000077526:Tropisetron; D000077334:Zolpidem
Pittsburgh Sleep Quality Index (PSQI); postoperative pain; recovery; sleep quality; total knee arthroplasty (TKA)