The role of ion channels in malignant brain tumors.
Malignant gliomas are the most common primary brain tumors and have poor clinical prognosis, despite multimodal therapeutic strategies. In recent years, ion channels have emerged as major players in tumor pathophysiology regarding all hallmarks of cancer. Since ion channels are easily accessible structures, they may prove to be effective targets for canner therapy, although their broad expression pattern and role in physiological processes should be taken into consideration. This review summarizes the current knowledge on the role of ion channels in the pathophysiology of malignant gliomas, especially glioblastoma, and evaluates their potential role in targeted antiglioma therapy.
Department of Neurology, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. ole.simon@ukmuenster.de.
Ole J
OJ
Simon
Department of Neurology, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Thomas
T
Müntefering
Department of Neurology, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Oliver M
OM
Grauer
Department of Neurology, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Sven G
SG
Meuth
D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007473:Ion Channels / Q000235:genetics* / Q000378:metabolism*
D007473:Ion Channels
Brain tumor; Ion channels; Malignant glioma; Tumor cells