The role of acoustofluidics in targeted drug delivery.
With the fast development of acoustic systems in clinical and therapeutic applications, acoustically driven microbubbles have gained a prominent role as powerful tools to carry, transfer, direct, and target drug molecules in cells, tissues, and tumors in the expanding fields of targeted drug delivery and gene therapy. The aim of the present study is to establish a biocompatible acoustic microfluidic system and to demonstrate the generation of an acoustic field and its effects on microbubbles and biological cells in the microfluidic system. The acoustic field creates non-linear oscillations of the microbubble-clusters, which results in generation of shear stress on cells in such microsystems. This effectively helps in delivering extracellular probes in living cells by sonoporation. The sonoporation is investigated under the combined effects of acoustic stress and hydrodynamic stress during targeted drug and gene delivery.
Department of Biotechnology, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
Nilanjana
N
Bose
Bioengineering Group, Engineering Sciences, University of Southampton , Southampton SO17 1BJ, United Kingdom.
Xunli
X
Zhang
Department of Biotechnology, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
Tapas K
TK
Maiti
Department of Mechanical Engineering, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
Suman
S
Chakraborty