External beam radiotherapy in differentiated thyroid carcinoma: A systematic review.
External beam radiotherapy (EBRT) is not a first line treatment in differentiated thyroid carcinoma (DTC), but is recommended as an adjuvant treatment in certain cases. The evidence for EBRT in DTC is limited. A comprehensive literature search was performed. Data on patient demographics, disease stage, treatment characteristics, and outcomes were collected from included articles after quality appraisal. Sixteen articles met the inclusion criteria, with a pooled population of 5114. Only 1 study was prospective and there were no randomized controlled trials. Most of the evidence suggests that EBRT improves locoregional control in patients at high risk of locoregional recurrence. This was corroborated by analysis of pooled patient data. Available evidence suggests an improvement in locoregional control when EBRT is used in patients over the age of 45 at high risk for locoregional recurrence. However, there is a need for long-term prospective multicenter research on the subject. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2297-E2305, 2016.
Institute of Head and Neck Studies and Education, School of Cancer Sciences, University of Birmingham, United Kingdom.
Jonathan M
JM
Fussey
Institute of Head and Neck Studies and Education, School of Cancer Sciences, University of Birmingham, United Kingdom.
Rosa
R
Crunkhorn
Institute of Head and Neck Studies and Education, School of Cancer Sciences, University of Birmingham, United Kingdom.|Department of ENT Surgery, University Hospitals Coventry and Warwickshire, United Kingdom.|Medical School of Comenius University, Bratislava, Slovakia.
Miroslav
M
Tedla
Department of Endocrinology, University Hospitals Coventry and Warwickshire, United Kingdom.
Martin O
MO
Weickert
Institute of Head and Neck Studies and Education, School of Cancer Sciences, University of Birmingham, United Kingdom.
Hisham
H
Mehanna
D018263:Adenocarcinoma, Follicular / Q000532:radiotherapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D018714:Radiotherapy, Adjuvant; D013964:Thyroid Neoplasms / Q000532:radiotherapy*
follicular thyroid carcinoma; papillary thyroid carcinoma; radiotherapy; review; thyroid carcinoma