Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis.
Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (HHVs) such as HHV-6, HHV-7, cytomegalovirus (CMV) and Epstein-Barr virus. Various complications, including autoimmune diseases, sometimes appear during the course of DIHS. We report a case of salazosulfapyridine-induced DIHS associated with HHV-6 reactivation. Two and a half months after the onset of DIHS, subacute thyroiditis occurred, possibly associated with CMV reactivation. Prednisolone (20 mg/day) was effective for subacute thyroiditis. Long-term follow-up is needed in patients with DIHS because of the possible onset of autoimmune diseases.
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Mika
M
Sato
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Yuki
Y
Mizuno
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Kanako
K
Matsuyama
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
En
E
Shu
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Hiroyuki
H
Kanoh
Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.
Tetsuya
T
Suwa
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Mariko
M
Seishima
Cytomegalovirus; Drug rash with eosinophilia and systemic symptoms; Drug-induced hypersensitivity syndrome; Human herpesvirus 6; Subacute thyroiditis