First impressions about Adherus, a new dural sealant.
OBJECTIVE
The aim of the study is to report our first impressions about Adherus, a novel dural sealant, used in neurosurgical endoscopic transnasal procedures.


METHODS
We retrospectively reviewed the clinical and surgical records of the first 11 patients with intraoperative high-flow cerebrospinal fluid leak treated with the aid of Adherus at our center between February and October 2014. The healing at the level of the dural plasty was monitored and evaluated radiologically and with regular endoscopic inspections.


RESULTS
With a median follow-up of 210 days, no postoperative CSF leak or surgical site infections were found in any of the cases.


CONCLUSIONS
Based on our preliminary experience, this new dural sealant seems to provide an effective aid in dural plasty during endoscopic transphenoidal procedures.
Neurosurgery Department, IRCCS Fondazione Policlinico San Matteo, Pavia - Italy.
Cesare
C
Zoia
Neurosurgery Departement of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia - Italy.
Daniele
D
Bongetta
Neurosurgery Department, IRCCS Fondazione Policlinico San Matteo, Pavia - Italy.
Francesco
F
Lombardi
Neurosurgery Department, IRCCS Fondazione Policlinico San Matteo, Pavia - Italy.
Viola Marta
VM
Custodi
Neurosurgery Department, IRCCS Fondazione Policlinico San Matteo, Pavia - Italy.
Raffaelino
R
Pugliese
Neurosurgery Department, IRCCS Fondazione Policlinico San Matteo, Pavia - Italy.
Paolo
P
Gaetani
D020863:Central Nervous System Cysts / Q000175:diagnosis / Q000601:surgery; D065634:Cerebrospinal Fluid Leak / Q000628:therapy*; D004724:Endoscopy; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry; D012189:Retrospective Studies; D014014:Tissue Adhesives / Q000737:chemistry / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D014014:Tissue Adhesives; D011092:Polyethylene Glycols; D011094:Polyethyleneimine