Bilirubin Levels and Thrombus Burden in Patients With ST-Segment Elevation Myocardial Infarction.
We investigated whether serum bilirubin level (a marker of heme oxygenase activity) is a predictor of thrombus burden in patients with acute myocardial infarction. Patients (n = 229; male 72.9%; mean age 63 ± 13.4 years) who were admitted with ST-segment elevation myocardial infarction (STEMI) were enrolled. Patients were divided into 2 groups. Group 1 was defined as low thrombus burden and group 2 was defined as high thrombus burden. Patients with high thrombus burden had higher total bilirubin levels (14.4 [4.3-22.9] vs 7.7 [2.4-20.3] µmol/L, P ≤ .001), (0.84 [0.25-1.34] vs 0.45 [0.14-1.19] mg/dL P ≤ .001) and direct bilirubin levels (3.1 [2.1-8.4] vs 1.7 [0.5-6.5] µmol/L, P ≤ .001), (0.18 [0.03-0.49] vs 0.10 [0.03-0.38] mg/dL, P ≤ .001). At multivariate analysis, total bilirubin (odds ratio: 1.05, 95% confidence interval: 1.03-1.08, P ≤ .001) was the independent predictor of high thrombus burden. In conclusion, total bilirubin level is independently associated with high thrombus burden in patients with STEMI.
Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey hikmethamur@hotmail.com.
Hikmet
H
Hamur
Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
Hakan
H
Duman
Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
Eftal Murat
EM
Bakirci
Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
Zafer
Z
Kucuksu
Department of Cardiology, Training and Research Hospital, Erzurum, Turkey.
Selami
S
Demirelli
Department of Cardiology, Training and Research Hospital, Erzurum, Turkey.
Kamuran
K
Kalkan
Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
Husnu
H
Degirmenci
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003328:Coronary Thrombosis / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D012720:Severity of Illness Index
D015415:Biomarkers; D001663:Bilirubin
bilirubin; myocardial infarction; thrombus burden