Nanofibrous scaffolds in biomedical applications.
Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation. In comparison to other forms of scaffolds, the nanofibrous scaffolds promote cell adhesion, proliferation and differentiation more efficiently due to having high surface to volume ratio. Although scaffolds for tissue engineering have been fabricated by various techniques but electrospun nanofibrous scaffolds have shown great potential in the fields of tissue engineering and regeneration. This review highlights the applications and importance of electrospun nanofibrous scaffolds in various fields of biomedical applications ranging from drug delivery to wound healing. Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning. The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications.
Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea ; Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247 667 India.
Kailash Chandra
KC
Gupta
Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea.
Adnan
A
Haider
Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea.
Yu-Ri
YR
Choi
Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea.
Inn-Kyu
IK
Kang
Bioactive agent; Drug delivery; Electrospinning; Tissue engineering; Wound healing