Didecarboxylative Iron-Catalyzed Bidirectional Aldolization towards Diversity-Oriented Ketodiol Synthesis.
1,3-Acetonedicarboxylic acid was selectively activated by Fe(acac)3 , providing a synthetic platform for rapid synthesis of keto-3,3'-diols. The bidirectional aldol reaction was efficient for challenging aliphatic aldehydes, providing a rapid route to potentially bioactive complex structures.
Aix Marseille Université, Centrale Marseille, CNRS, iSm2 UMR 7313, 13397, Marseille (France). adrien.quintard-inv@univ-amu.fr.
Adrien
A
Quintard
Aix Marseille Université, Centrale Marseille, CNRS, iSm2 UMR 7313, 13397, Marseille (France). jean.rodriguez@univ-amu.fr.
Jean
J
Rodriguez
aldolization; decarboxylation; homogeneous catalysis; iron; polyols