Biocompatible and Antibacterial SnO2 Nanowire Films Synthesized by E-Beam Evaporation Method.
In this work, the biocompatibility and antibacterial activities of novel SnO2 nanowire coatings prepared by electron-beam (E-Beam) evaporation process at low temperatures were studied. The nanowire coatings were characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), and X-ray diffraction (XRD) methods. The results of in vitro cytotoxicity and cell proliferation assays suggested that the SnO2 nanowire coatings were nontoxic and promoted the proliferation of C2C12 and L929 cells (> 90% viability). Cellular activities, cell adhesion, and lactate dehydrogenase activities were consistent with the superior biocompatibility of the nanowire materials. Notably, the nanowire coating showed potent antibacterial activity against six different bacterial strains. The antibacterial activity of the SnO2 material was attributed to the photocatalytic nature of SnO2. The antibacterial activity and biocompatibility of the newly developed SnO2 nanowire coatings may enable their use as coating materials for biomedical implants.
R G S V
RG
Prasad
A R
AR
Phani
K N
KN
Rao
R Rakesh
RR
Kumar
S
S
Prasad
G
G
Prabhakara
M S
MS
Sheeja
C P
CP
Salins
J L
JL
Endrino
D B
DB
Raju
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D007834:Lasers; D008422:Materials Testing; D051379:Mice; D008826:Microbial Sensitivity Tests; D036103:Nanotechnology / Q000379:methods*; D053770:Nanowires / Q000737:chemistry*; D013499:Surface Properties; D017971:Tin Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014025:Titanium / Q000737:chemistry; D014835:Volatilization; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D017971:Tin Compounds; C009495:titanium dioxide; D014025:Titanium; C045358:stannic oxide