Prognostic Factors of Clinical Outcomes in Patients with Spontaneous Thalamic Hemorrhage.
BACKGROUND
Intracerebral hemorrhage (ICH) is a well-known condition, but ICH restricted to the thalamus is less widely studied. We investigated the prognostic factors of thalamic ICHs.


METHODS
Seventy patients from January 2009 to November 2014 were retrospectively reviewed. Patients who demonstrated spontaneous ICH primarily affecting the thalamus on initial brain computed tomography (CT) were enrolled. Patients were categorized into 2 groups based on their Glasgow Outcome Scale (GOS) scores. Various presumptive prognostic factors were analyzed to investigate relationships between various clinical characteristics and outcomes.


RESULTS
Of the enrolled patients, 39 showed a GOS of 4-5, and were categorized as the good outcome group, while another 31 patients showed a GOS of 1-3 and were categorized as the poor outcome group. Initial GCS score, calculated volume of hematoma, presence of intraventricular hemorrhage (IVH), coexisting complications, hydrocephalus, performance of external ventricular drainage, and modified Graeb's scores of patients with IVH were significantly different between the 2 groups. In multivariate analysis, among the factors above, initial GCS score (P=0.002, Odds ratio [OR]=1.761, Confidence interval [CI]=1.223-2.536) and the existence of systemic complications (P=0.015, OR=0.059, CI=0.006-0.573) were independently associated with clinical outcomes. Calculated hematoma volume showed a borderline relationship with outcomes (P=0.079, OR=0.920, CI=0.839-1.010).


CONCLUSIONS
Initial GCS score and the existence of systemic complications were strong predictive factors for prognosis of thalamic ICH. Calculated hematoma volume also had predictive value for clinical outcomes.
Department of Neurosurgery, Korea University Medical Center, Korea University College of Medicine, Seoul, South Korea.
Sang-Hoon
SH
Lee
Department of Neurosurgery, Korea University Medical Center, Korea University College of Medicine, Seoul, South Korea.
Kyung-Jae
KJ
Park
Department of Neurosurgery, Korea University Medical Center, Korea University College of Medicine, Seoul, South Korea.
Shin-Hyuk
SH
Kang
Department of Neurosurgery, Korea University Medical Center, Korea University College of Medicine, Seoul, South Korea.
Yong-Gu
YG
Jung
Department of Neurosurgery, Korea University Medical Center, Korea University College of Medicine, Seoul, South Korea.
Jung-Yul
JY
Park
Department of Neurosurgery, Korea University Medical Center, Korea University College of Medicine, Seoul, South Korea.
Dong-Hyuk
DH
Park
D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000628:therapy*; D004322:Drainage; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013788:Thalamus / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome