The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.
Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.
Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary.
Nikolett
N
Marton
Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary.
Eszter
E
Baricza
Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary ; MTA-SE "Lendület" Experimental and Translational Immunomics Research Group, 4 Nagyvárad Square, Budapest 1089, Hungary.
Barbara
B
Érsek
Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary.
Edit I
EI
Buzás
Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary ; Department of Rheumatology, Faculty of Medicine, Semmelweis University, 4 Frankel Leó Street, Budapest 1023, Hungary.
György
G
Nagy
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; C441328:SLA2 protein, human; D016392:Proto-Oncogene Proteins pp60(c-src)