[Genetic and biochemical mechanisms of involvement of antioxidant defense enzymes in the development of bronchial asthma].
In the present review we have analyzed and summarized recent literature data on genetic and biochemical mechanisms responsible for involvement of antioxidant defense enzymes in the etiology and pathogenesis of bronchial asthma. It has been shown that the mechanisms of asthma development are linked with genetically determined abnormalities in the functioning of antioxidant defense enzymes. These alterations are accompanied by a systemic imbalance between oxidative and anti-oxidative reactions with the shift of the redox state toward increased free radical production and oxidative stress, a key element in the pathogenesis of bronchial asthma.
Kursk State Medical University, Kursk, Russia.
A V
AV
Polonikov
Kursk State Medical University, Kursk, Russia.
V P
VP
Ivanov
Kursk State Medical University, Kursk, Russia.
A D
AD
Bogomazov
Kursk State Medical University, Kursk, Russia.
M A
MA
Solodilova
D001249:Asthma / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D001980:Bronchi / Q000201:enzymology* / Q000473:pathology; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005721:Glutamate-Cysteine Ligase / Q000235:genetics / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone); D019255:NADPH Oxidases / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D009195:Peroxidase / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D000094765:Glutathione Peroxidase GPX1
D002374:Catalase; D005721:Glutamate-Cysteine Ligase; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D016660:NAD(P)H Dehydrogenase (Quinone); D019255:NADPH Oxidases; D009195:Peroxidase; D000094765:Glutathione Peroxidase GPX1; C086986:CYBA protein, human; C447479:NQO1 protein, human; C413545:glutathione S-transferase T1; C546365:GCLM protein, human; C000722067:GPX1 protein, human
antioxidant defense enzymes; biochemical abnormalities; bronchial asthma; etiology and pathogenesis; free radical processes; genetic polymorphism; oxidative stress