Association of cord blood levels of IL-17A, but not TGF-β with pre-term neonate.
BACKGROUND
It has been documented that cytokines play important roles in the induction of normal functions of the placenta. It has been hypothesized that abnormal expression of the cytokines may be associated with unsuccessful pregnancy.


OBJECTIVE
The aim of this study was to compare the serum levels of interleukin-17A (IL-17A) and tumor growth factor (TGF-β) in pre-term, term neonates, and their corresponding mothers.


METHODS
This study was performed on 100 term and 60 pre-term neonates, and also on their corresponded mothers. Serum levels of IL-17A and TGF-β were examined by enzyme linked immunosorbent assay (ELISA).


RESULTS
Our results revealed that the serum levels of IL-17A were significantly decreased in pre-term neonates in comparison to full-term neonates. However, the serum levels of IL-17A in the mothers either with pre-term or full-term neonates were not different. Also the serum levels of TGF-β were not changed in pre-term neonates and their mothers when compared with full-term neonates and their mothers, respectively.


CONCLUSIONS
Based on these findings, it can be concluded that IL-17A may play crucial roles in induction of normal pregnancies and also probably participates in normal growth of fetus.
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Masoud
M
Mobini
Department of Obstetrics and Gynecology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Sakineh
S
Mirzaie
Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Hossein
H
Khorramdelazad
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Nahid
N
Zainodini
Department of Obstetrics and Gynecology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Zahra
Z
Sabzali
Department of Obstetrics and Gynecology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Mina
M
Ghyasi
Department of Obstetrics and Gynecology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Mitra
M
Mokhtari
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Reza
R
Bahramabadi
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Hamid
H
Hakimi
Department of Immunology, AJA University of Medical Sciences, Tehran, Iran.
Khodayar
K
Ghorban
Department of Infectious Diseases, AJA University of Medical Sciences, Tehran, Iran.
Maryam
M
Dadmanesh
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Vahid
V
Ehsani
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Mohammad
M
Kazemi Arababadi
IL-17A; Pre-term delivery; Pregnancy; TGF-β