[Frequency of spontaneous aneuploidy in the healthy Hungarian population].
Aneuploidy plays very important role in tumor development as the consequence of either congenital or acquired mutations. In order to evaluate the adverse effects of various aneugens, the knowledge of the spontaneous frequency of numerical chromosome abnormalities in healthy population is fundamental. In our study we analyzed the spontaneous rate of numerical and structural chromosome aberrations in peripheral blood lymphocytes of 2145 healthy individuals, with special attention to the influence of biological (gender, age) and life-style factors (smoking, different occupational exposure). Correlation between aneuploidy and risk of cancer development were investigated according to National Cancer Registry data followed for 1-23 years. In the whole population the average frequency of aneuploid cells was 1.77±0.06%. This value increased by age linearly (r2=0.81) regardless of occupational exposures. Gender (biological factor) or smoking (life style factor) did not influence the values, however, the occupation of individuals modified the frequency of numerical aberrations. Individuals who worked at workplaces with radiation hazard had the lowest (1.44±0.10%), and those working in the chemical industry had the highest (1.89±0.05%) values of aneuploidy, respectively. We could not find any correlation between numerical and structural chromosome aberrations. In our population studied 97 individuals developed cancer and only those who had ≤2% aneuploidy survived more than 12 years in good health conditions. To our knowledge, this study has the highest case number investigated up to now. Our results support that aneuploidy, similarly to structural chromosomal aberrations, might be an additional cytogenetic biomarker of the genetic instability.
Sugárterápiás Központ, Országos Onkológiai Intézet, Klinikai Sugárbiológiai és Diagnosztikus Onkocytogenetikai Osztály, Budapest, Hungary. farkas.gyongyi@oncol.hu.
Gyöngyi
G
Farkas
Sugárterápiás Központ, Országos Onkológiai Intézet, Klinikai Sugárbiológiai és Diagnosztikus Onkocytogenetikai Osztály, Budapest, Hungary. farkas.gyongyi@oncol.hu.
Gábor
G
Székely
Sugárterápiás Központ, Országos Onkológiai Intézet, Klinikai Sugárbiológiai és Diagnosztikus Onkocytogenetikai Osztály, Budapest, Hungary. farkas.gyongyi@oncol.hu.
Nagyezsda
N
Vass
Sugárterápiás Központ, Országos Onkológiai Intézet, Klinikai Sugárbiológiai és Diagnosztikus Onkocytogenetikai Osztály, Budapest, Hungary. farkas.gyongyi@oncol.hu.
Krisztina
K
Kiss
Sugárterápiás Központ, Országos Onkológiai Intézet, Klinikai Sugárbiológiai és Diagnosztikus Onkocytogenetikai Osztály, Budapest, Hungary. farkas.gyongyi@oncol.hu.
Sarolta
S
Gundy
D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D059785:Karyotype; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*