Palladium-catalyzed one-pot synthesis of diazoles via tert-butyl isocyanide insertion.
An efficient one-pot palladium-catalyzed reaction for the synthesis of diazoles from readily available hydrazides and aryl halide via isocyanide insertion/cyclization sequence has been developed. This methodology efficiently constructs diazoles in good to excellent yields with the advantages of wide functional group tolerance and operational simplicity.
College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. zhuyongming@suda.edu.cn.
Xiang-Yuan
XY
Fan
Xiao
X
Jiang
Ying
Y
Zhang
Zhen-Bang
ZB
Chen
Yong-Ming
YM
Zhu
D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D001393:Azoles; D009570:Nitriles; D009942:Organometallic Compounds; D010165:Palladium; C099535:tert-butyl isocyanide