Synthesis of different sized and porous hydroxyapatite nanorods without organic modifiers and their 5-fluorouracil release performance.
Porous biocompatible hydroxyapatite (HAP) nanorods of various sizes were synthesized by the combination of chemical precipitation and hydrothermal method without the use of organic modifiers. The HAP nanorod samples were characterized by powder X-ray diffraction, transmission electron microscopy, and N2 adsorption/desorption techniques. HAP nanorods with average diameters and average lengths ranging from 8.5 to 26.6 nm and from 23.1 to 49.7 nm, respectively, could be controllably synthesized via these methods. Low autoclaving temperature and high pH value favored the formation of relatively small HAP nanorods. The TEM images showed that the nanorods possessed porous structures with average pore diameters ranging from 1.6 to 2.7 nm. These HAP nanoparticles effectively prolonged the release time of 5-fluorouracil up to 24h. The as-synthesized HAP nanorods displayed no cytotoxicity to bone marrow stem cells at low HAP concentration, indicating that these nanorod materials could serve as potential carriers for novel drug release systems.
Faculty of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Yuqin
Y
Ji
Faculty of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Aili
A
Wang
Department of Stomatology, Chinese PLA 359 Hospital, Zhenjiang 212006, China.
Gang
G
Wu
Faculty of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: yin@ujs.edu.cn.
Hengbo
H
Yin
School of Chemistry and Chemical Engineering, Mianyang Normal University, Mianyang 621000, China.
Shuxin
S
Liu
Department of Orthopaedics, Chinese PLA 359 Hospital, Zhenjiang 212006, China.
Bujun
B
Chen
Department of Orthopaedics, Chinese PLA 359 Hospital, Zhenjiang 212006, China.
Fanggang
F
Liu
Faculty of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Xiaoyun
X
Li
D065966:Absorption, Physicochemical; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D017886:Durapatite / Q000737:chemistry*; D005472:Fluorouracil / Q000008:administration & dosage / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D058608:Nanopores / Q000648:ultrastructure*; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D009930:Organic Chemicals / Q000737:chemistry; D010316:Particle Size; D016062:Porosity
D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D009930:Organic Chemicals; D017886:Durapatite; D005472:Fluorouracil
5-Fluorouracil; Chemical precipitation; Drug release; Hydrothermal; Hydroxyapatite nanorods