NIK1, a host factor specialized in antiviral defense or a novel general regulator of plant immunity?
NIK1 is a receptor-like kinase involved in plant antiviral immunity. Although NIK1 is structurally similar to the plant immune factor BAK1, which is a key regulator in plant immunity to bacterial pathogens, the NIK1-mediated defenses do not resemble BAK1 signaling cascades. The underlying mechanism for NIK1 antiviral immunity has recently been uncovered. NIK1 activation mediates the translocation of RPL10 to the nucleus, where it interacts with LIMYB to fully down-regulate translational machinery genes, resulting in translation inhibition of host and viral mRNAs and enhanced tolerance to begomovirus. Therefore, the NIK1 antiviral immunity response culminates in global translation suppression, which represents a new paradigm for plant antiviral defenses. Interestingly, transcriptomic analyses in nik1 mutant suggest that NIK1 may suppress antibacterial immune responses, indicating a possible opposite effect of NIK1 in bacterial and viral infections.
Departamento de Bioquímica e Biologia Molecular, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, Brazil.
Joao P B
JP
Machado
Departamento de Bioquímica e Biologia Molecular, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, Brazil.
Otavio J B
OJ
Brustolini
Departamento de Bioquímica e Biologia Molecular, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, Brazil.
Giselle C
GC
Mendes
Departamento de Bioquímica e Biologia Molecular, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, Brazil.
Anésia A
AA
Santos
Departamento de Bioquímica e Biologia Molecular, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, Brazil.
Elizabeth P B
EP
Fontes
D017360:Arabidopsis / Q000276:immunology* / Q000821:virology*; D029681:Arabidopsis Proteins / Q000276:immunology*; D053839:Begomovirus / Q000276:immunology*; D018551:Solanum lycopersicum / Q000276:immunology / Q000821:virology; D010766:Phosphorylation; D057865:Plant Immunity / Q000276:immunology*; D014176:Protein Biosynthesis / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000276:immunology*; D021381:Protein Transport / Q000276:immunology; D000080882:Ribosomal Protein L10; D012269:Ribosomal Proteins / Q000378:metabolism; D015398:Signal Transduction; D013025:Glycine max / Q000276:immunology / Q000821:virology
D029681:Arabidopsis Proteins; D012269:Ribosomal Proteins; C000630691:ribosomal protein L10, Arabidopsis; C000597753:NIK1 protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases
NIK1; NSP-interacting kinase; begomoviruses; immune receptor; immune responses; plant antiviral immunity; translation suppression