Reduced ovarian reserve in patients with adult polymyositis.
Polymyositis (PM) affects female gender during reproductive age; however, there is no study assessing ovarian reserve in these patients to evaluate ovarian reserve markers in PM. Eight female patients with PM (Bohan and Peter criteria, 1975) with aged 18-40 years, followed at our tertiary centre from March 2011 to May 2014, were invited to participate. They were age-matched with 16 healthy individuals (control group). All were evaluated at early follicular phase of menstrual cycle. Follicle stimulating hormone (FSH), estradiol, inhibin B, anti-Müllerian hormone (AMH) serum levels (ELISA) and sonographic antral follicle count (AFC) were determined. PM patients and controls had comparable mean age (31.4 ± 6.5 vs. 30.7 ± 6.2 years, P = 0.946), ethnicity and socioeconomic class (P > 0.05). PM mean age of onset was 27.3 ± 6.5 years and disease duration of 6.5 ± 4.1 years. Menstrual cycles were alike in both groups with a similar frequency of age at menarche, gynaecological age, duration and length of menstrual cycle (P > 0.05). The median serum level of AMH was significantly lower in PM compared to controls [0.7(0.3-3.4) vs. 3.1(1.4-4.0), P = 0.021]. AMH levels ≤1 ng/mL (50 vs. 6.3 %, P = 0.024) and very low AFC (37.5 vs. 6.3 %, P = 0.037) were significantly in PM patients versus controls. The other hormones (FSH, inhibin B and estradiol levels) were similar between both groups (P > 0.05). The present study was the first to identify subclinical ovarian dysfunction in PM patients during reproductive ages. Further study is necessary to assess the possible role of PM-related factors that may influence the ovarian function of these patients.
Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Fernando Henrique Carlos
FH
de Souza
Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.|Pediatric Rheumatology Unit-Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Clovis Artur
CA
da Silva
Division of Gynaecology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Lucas Yugo Shiguehara
LY
Yamakami
Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Vilma
V
dos Santos Trindade Viana
Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Eloisa
E
Bonfá
Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. samuel.shinjo@gmail.com.|Disciplina de Reumatologia, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455, 3 andar, sala 3150, 01246-903, São Paulo, Brazil. samuel.shinjo@gmail.com.
Samuel Katsuyuki
SK
Shinjo
D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005498:Follicular Phase; D006801:Humans; D007249:Inflammation; D007265:Inhibins / Q000097:blood; D009135:Muscular Diseases / Q000150:complications / Q000473:pathology; D010049:Ovarian Diseases / Q000150:complications / Q000473:pathology; D006080:Ovarian Follicle / Q000166:cytology; D065851:Ovarian Reserve; D017285:Polymyositis / Q000150:complications*; D012923:Social Class; D055815:Young Adult
C422364:inhibin B; D004958:Estradiol; D007265:Inhibins; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
Anti-Müllerian hormone; Antral follicle count; Idiopathic inflammatory myopathies; Ovarian reserve; Polymyositis