Poly(trimethylene carbonate)-based polymers engineered for biodegradable functional biomaterials.
Aliphatic polycarbonates have drawn attention as biodegradable polymers that can be applied to a broad range of resorbable medical devices. In particular, poly(trimethylene carbonate) (PTMC), its copolymers, and its derivatives are currently studied due to their unique degradation characteristics that are different from those of aliphatic polyesters. Furthermore, their flexible and hydrophobic nature has driven the application of PTMC-based polymers to soft tissue regeneration and drug delivery. This review presents the diverse applications and functionalization strategies of PTMC-based materials in relation to recent advances in medical technologies and their subsequent needs in clinical settings.
Department of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata 992-8510, Japan. fukushima@yz.yamagata-u.ac.jp.
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D001672:Biocompatible Materials / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D016503:Drug Delivery Systems; D006801:Humans; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D023822:Tissue Engineering
D001672:Biocompatible Materials; D004146:Dioxanes; D011108:Polymers; C059299:polytrimethylene carbonate