[Novel endoscopic techniques to image the upper gastrointestinal tract].
Novel endoscopic techniques for the analysis of the digestive wall have recently been developed to allow investigating digestive diseases beyond standard "white-light" macroscopic imaging of the mucosal surface. Among innovative techniques under clinical evaluation, confocal endomicroscopy and optical frequency domain imaging (OFDI) are the most promising. Indeed, these techniques allow performing in vivo microscopy with different levels in terms of depths and magnification, as well as functional assessment of structures. Some of these techniques, such as capsule-based OFDI, are also less invasive than traditional endoscopy and might help screening large groups of patients for specific disorders, for instance oesophageal precancerous diseases. In this review, we will focus on the results obtained with these techniques in precancerous, inflammatory and neuromuscular disorders.
Institut des maladies de l'appareil digestif, CHU de Nantes, hôpital Hôtel-Dieu, 1, place Alexis Ricordeau, F-44093 Nantes, France - Inserm U913, F-44093 Nantes, France.
Lucille
L
Quénéhervé
Inserm U913, F-44093 Nantes, France.
Michel
M
Neunlist
Institut des maladies de l'appareil digestif, CHU de Nantes, hôpital Hôtel-Dieu, 1, place Alexis Ricordeau, F-44093 Nantes, France - Inserm U913, F-44093 Nantes, France.
Stanislas
S
Bruley des Varannes
Harvard medical school et Wellman center for photo-medicine, Massachusetts general hospital, 55 Fruit street, Boston, MA 02114, États-Unis.
Guillermo
G
Tearney
Institut des maladies de l'appareil digestif, CHU de Nantes, hôpital Hôtel-Dieu, 1, place Alexis Ricordeau, F-44093 Nantes, France - Inserm U913, F-44093 Nantes, France.
Emmanuel
E
Coron
D016099:Endoscopy, Gastrointestinal / Q000379:methods; D005767:Gastrointestinal Diseases / Q000473:pathology*; D006801:Humans; D041742:Upper Gastrointestinal Tract