Urinary Excretion of Myo-Inositol and D-Chiro-Inositol in Early Pregnancy Is Enhanced in Gravidas With Gestational Diabetes Mellitus.
The effects of gestational diabetes mellitus (GDM) were determined on urinary excretion of putative components of insulin signaling. Random urine samples were collected from 375 gravidas at 6 to 14 weeks' gestation, 22 to 32 weeks' gestation, and ∼6 weeks' postpartum. Gestational diabetes mellitus developed in 35 women who were matched with 59 normal gravidas. Urinary concentrations of myo-inositol (MI) and D-chiro-inositol (DCI) were measured by gas chromatography/mass spectrometry and normalized to creatinine levels. Compared to postpartum values, urinary excretion of MI and DCI was increased 2.9-fold and 2-fold, respectively, in early pregnancy, and 5.5-fold and 4.5-fold, respectively, in later gestation. Gravidas with GDM had significantly greater MI and DCI excretion than controls in the first trimester but not subsequently. The results suggest that gravidas destined to develop GDM have altered synthesis, metabolism, and/or renal excretion of MI and DCI in early pregnancy.
Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California, Los Angeles, California amurphy@mednet.ucla.edu.
Aisling
A
Murphy
Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California, Los Angeles, California.
Amir
A
Shamshirsaz
Department of Biomathematics, David Geffen School of Medicine at the University of California, Los Angeles, California.
Daniela
D
Markovic
Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University in St Louis, St Louis, Missouri.
Richard
R
Ostlund
Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California, Los Angeles, California.
Brian
B
Koos
D000328:Adult; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000652:urine*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D020073:Gravidity / Q000502:physiology*; D006801:Humans; D007294:Inositol / Q000652:urine*; D007295:Inositol Phosphates / Q000652:urine*; D011134:Polysaccharides / Q000652:urine*; D049590:Postpartum Period / Q000652:urine; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000652:urine*; D011897:Random Allocation
D015415:Biomarkers; D007295:Inositol Phosphates; D011134:Polysaccharides; C028039:inositol phosphate glycan; D007294:Inositol
gestational diabetes; inositols; pregnancy; urine