Depigmenting Effect of Winter Medicinal Mushroom Flammulna velutipes (Higher Basidiomycetes) on Melanoma Cells.
In humans, skin pigmentation results from the biochemichal synthesis and accumulation of melanin. We previously revealed that edible winter mushroom Flammulina velutipes extract inhibited melanosis in commercially available edible crustacea. Therefore, the current study was conducted to find if edible mushrooms extracts are useful for the skin whitening and the underlying mechanisms in melanin biosynthesis. Tyrosinase is one of the key enzymes for melanin biosynthesis. This study demonstrated that melanin synthesis and tyrosinase activity were suppressed by the F. velutipes extracts in B16 murine melanoma cells through the slow expression of microphthalmia-associated transcription factor. These results suggested that the F. velutipes extract could contain an effective component in whitening cosmetics and an alternative therapeutic agent for treating hyperpigmentation.
Department of Food Science and Technology, Graduate School of Marine Science and Technology, Konan 5-4-7, Minato-ku, Tokyo 108-8477, Japan.
Reiko
R
Nagasaka
Department of Food Science and Technology, Graduate School of Marine Science and Technology, Konan 5-4-7, Minato-ku, Tokyo 108-8477, Japan.
Yuki
Y
Ishikawa
Department of Food Science and Technology, Graduate School of Marine Science and Technology, Konan 5-4-7, Minato-ku, Tokyo 108-8477, Japan.
Takumi
T
Inada
Department of Food Science and Technology, Graduate School of Marine Science and Technology, Konan 5-4-7, Minato-ku, Tokyo 108-8477, Japan.
Toshiaki
T
Ohshima
D000818:Animals; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000378:metabolism*; D055393:Flammulina / Q000737:chemistry*; D006801:Humans; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D014157:Transcription Factors / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D008543:Melanins; D014157:Transcription Factors; D014442:Monophenol Monooxygenase