Redox Modulation by Reversal of the Mitochondrial Nicotinamide Nucleotide Transhydrogenase.
The mitochondrial nicotinamide nucleotide transhydrogenase (NNT) uses the protonmotive force to transfer electrons from NADH to NADP, thereby maintaining the NADP/NADPH pool reduced to protect mitochondria from oxidative damage. In this issue, Nickel et al. (2015) show that NNT also operates in reverse, oxidizing the NADP/NADPH pool, thereby disrupting antioxidant defense.
MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. Electronic address: mpm@mrc-mbu.cam.ac.uk.
Michael P
MP
Murphy
D000818:Animals; D006333:Heart Failure / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D009250:NADP Transhydrogenases / Q000378:metabolism*; D018384:Oxidative Stress
D009249:NADP; D009250:NADP Transhydrogenases