Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder.
The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7-14 years. Following treatment, patients' leptin levels increased and ghrelin levels decreased while no significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.
Fatih
F
Gurbuz
Berrak Bilginer
BB
Gurbuz
Gonca Gul
GG
Celik
Veli
V
Yildirim
Seyit Ahmet
SA
Ucakturk
Gulsah
G
Seydaoglu
Eda Mengen
http://orcid.org/0000-0003-1597-8418
EM
Ucakturk
Ali Kemal
AK
Topaloglu
Bilgin
B
Yuksel
D000293:Adolescent; D001066:Appetite / Q000187:drug effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D015415:Biomarkers / Q000097:blood; D001827:Body Height; D001835:Body Weight; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002648:Child; D002658:Developmental Disabilities / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D054439:Ghrelin / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D011446:Prospective Studies
D015415:Biomarkers; D000697:Central Nervous System Stimulants; D054439:Ghrelin; D020738:Leptin; D008774:Methylphenidate