Metalloproteinases and leptin in vehicle drivers of public service with metabolic syndrome in Armenia, Quindío.
OBJECTIVE
To describe the relationship between metalloproteinase (MMP) 2, MMP-9, and leptin in drivers of public service vehicles with metabolic syndrome in the city of Armenia (Quindio, Colombia).


METHODS
Leptin was measured using Millipore ELISA kits. MMP-2 and MMP-9 were measured with ELISA kits from R&D Systems.


RESULTS
Fifty-seven male drivers with metabolic syndrome with a mean age of 45.35years, BMI of 29.81, and an abdominal circumference of 105.75cm were identified. Blood pressure values were 126.5/82.5mmHg. Leptin, MMP-2, and MMP-9 levels were 24.6ng/mL, 28,1ng/mL, and 7.5ng/mL respectively. The relationship between leptin and waist circumference was statistically significant (P<.001). The explained variation (R(2)) in waist circumference, is explained in a 80.12% for the study variables, has a statistically significant association with BMI (P<.001), MMP-2 (P=.01), age (P=.01), SBP (P<.001) and DBP (P<.001). The R(2) of leptin, is explained in a 69.56% for the study variables, has a statistically significant association with BMI (P<.001), MMP-2 (P=.05) and triglycerides (P=.02). The R(2) of MMP-2, explained in 41.82% of the study variables and has a statistically significant association with waist circumference (P=.01), glucose (P=.01) and age (P=.03).


CONCLUSIONS
Statistically significant associations were found between waist circumference and MMP-2; leptin and MMP-2, and MMP-2 and waist circumference and blood glucose.
Grupo de Investigación en Enfermedades Cardiovasculares y Metabólicas, Gecavyme. Facultad de Ciencias de la Salud, Universidad del Quindío, Armenia, Quindío, Colombia. Electronic address: olgalicianieto@gmail.com.
Olga Alicia
OA
Nieto Cárdenas
D000328:Adult; D000367:Age Factors; D001136:Armenia; D001334:Automobile Driving; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D008019:Life Style; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood* / Q000201:enzymology; D008875:Middle Aged; D018986:Motor Vehicles; D009790:Occupations; D018384:Oxidative Stress; D012307:Risk Factors; D055105:Waist Circumference
D001786:Blood Glucose; D020738:Leptin; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
Leptin; Leptina; Matrix metalloproteinase-2; Matrix metalloproteinase-9; Metabolic syndrome; Metaloproteinasa de la matriz-2; Metaloproteinasa de la matriz-9; Síndrome metabólico