Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines.
A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva-King reaction, and a copper-catalyzed cyanation.
Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China. pinglu@zju.edu.cn orgwyg@zju.edu.cn.
Qiaodong
Q
Wen
Ping
P
Lu
Yanguang
Y
Wang
D000097:Acetonitriles / Q000737:chemistry*; D000098:Acetophenones / Q000737:chemistry*; D000631:Aminopyridines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
C000606910:3-cyanoimidazo(1,2-a)pyridine; D000097:Acetonitriles; D000098:Acetophenones; D000631:Aminopyridines; D007093:Imidazoles; D011725:Pyridines; C006725:benzyl cyanide; D003300:Copper; C032439:alpha-aminopyridine