Prostate-Type Adenocarcinoma in Mature Cystic Ovarian Teratoma.
We report our experience with prostatic-type tissue in ovarian teratomas, and in particular we highlight a case of prostatic-type adenocarcinoma arising within a mature cystic ovarian teratoma in a 32-yr-old woman. On gross examination, the cyst consisted of typical features of a dermoid cyst. Closer examination revealed a single 1.5-cm solid nodule within the cyst. Microscopically, it was composed of a small cyst-like structure lined by urothelium and to one side glandular and stromal tissue consistent with prostate parenchyma. Within the prostatic-type tissue, there were malignant glands morphologically and immunohistochemically supportive of prostatic-type adenocarcinoma Gleason score 3+3=6. There were also areas consistent with high-grade prostatic intraepithelial neoplasia. Although there are several reports in the literature of benign prostatic-type tissue arising within ovarian as well as testicular teratomas, to our knowledge, prostatic-type adenocarcinoma arising in a mature ovarian teratoma is an extremely rare phenomenon, with only 1 previous report in the literature.
Department of Obstetrics and Gynecology (J.S.) Section of Gynecologic Oncology (H.M., P.G.R.), Department of Obstetrics and Gynecology Departments of Anatomic Pathology (G.R., H.H., A.A.R.) Hematology and Oncology (D.S.), Cleveland Clinic, Cleveland, Ohio.
Jamie
J
Stanhiser
Haider
H
Mahdi
Gabriela
G
Rosa
Holly
H
Harper
Dale
D
Shepard
Peter G
PG
Rose
Andres A
AA
Roma
D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010051:Ovarian Neoplasms / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D013724:Teratoma / Q000473:pathology*
D014408:Biomarkers, Tumor