In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation.
The use of TFEDMA, a fluoroalkyl amino reagent, for the difluoromethylation and difluoroacylation of arenes, heteroarenes, and C-H acidic compounds is reported. This approach allows for an efficient access to difluoromethylated products of high added value in good to excellent yields and with scale-up possibilities.
CNRS-University of Strasbourg (ECPM) , UMR CNRS 7509, LCR Bayer-CNRS C2OF, 25 Rue Becquerel, 67087 Strasbourg, France.
Etienne
E
Schmitt
CNRS-University of Strasbourg (ECPM) , UMR CNRS 7509, LCR Bayer-CNRS C2OF, 25 Rue Becquerel, 67087 Strasbourg, France.
Baptiste
B
Rugeri
CNRS-University of Strasbourg (ECPM) , UMR CNRS 7509, LCR Bayer-CNRS C2OF, 25 Rue Becquerel, 67087 Strasbourg, France.
Armen
A
Panossian
Bayer S.A.S. , 14 Impasse Pierre Baizet, BP99163, Lyon 69263 Cedex 09, France.
Jean-Pierre
JP
Vors
Bayer CropScience AG , Alfred-Nobel-Strasse 50, 40789 Monheim, Germany.
Sergii
S
Pazenok
CNRS-University of Strasbourg (ECPM) , UMR CNRS 7509, LCR Bayer-CNRS C2OF, 25 Rue Becquerel, 67087 Strasbourg, France.
Frédéric R
FR
Leroux