[The selective toxic effect of dialdehyde derivatives of the pyrimidine nucleosides on human tumor cells].
The impact of a number of synthetic nucleoside derivatives on the growth and survival of cultured human ovarian tumor cells (line SKOV-3) and normal human lung fibroblasts was investigated. It was shown that the dialdehyde derivatives of uridine, 1-β-D-eritrofuranozyl uracil and 3'-O-β-D-ribofuranosyl-2'-deoxythymidine, in contrast to their unoxidized counterparts, exert marked toxic effect on SKOV-3 cells. Cultured human fibroblasts were less susceptible to the damaging effect of the dialdehyde nucleosides. The dialdehyde derivative of 1-β-D-eritrofuranozyl uracil demonstrated greatest differences in the cytotoxic effect on these cultures: inhibition of tumor SKOV-3 cells growth on 50% or more was achieved at the concentrations of this compound ten times lower than in the case of normal fibroblasts.
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
A S
AS
Efremova
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
S I
SI
Shram
Engelhardt Institute of Molecular Biology, Moscow, Russia.
M S
MS
Drenichev
Moscow Research Institute of Medical Ecology, Moscow, Russia.
G A
GA
Posypanova
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
N F
NF
Myasoedov
Engelhardt Institute of Molecular Biology, Moscow, Russia.
S N
SN
Mihaylov
D000447:Aldehydes / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005663:Furans / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009928:Organ Specificity; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D014529:Uridine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*
D000447:Aldehydes; D000970:Antineoplastic Agents; D003603:Cytotoxins; D005663:Furans; D014529:Uridine
SKOV3 human ovarian carcinoma cell line; antitumor action; cytotoxicity; dialdehyde derivatives of nucleosides; human fibroblasts