Urinary Tract Infection (UTI) Caused by Fusarium proliferatum in an Agranulocytosis Patient and a Review of Published Reports.
Infections caused by Fusarium species are increasing in frequency among immunocompromised hosts, but urinary tract infection (UTI) due to Fusarium proliferatum has not been reported in the literature so far. We describe a case of UTI caused by F. proliferatum in a 47-year-old man who was diagnosed with rectal cancer and metastasis. He underwent radical resection of rectal carcinoma and local resection of hepatic metastases. After the first adjuvant chemotherapy, the patient presented the obvious high fever, severely diarrhea and progressive decline of the white blood cell count. The direct microscopic examination of fungi in urine was positive, and the fungal cultures showed white, cotton-like colony. After the DNA sequencing, it was identified as F. proliferatum. We gave the patient itraconazole and other antibiotics to fight the infection. A month later, the temperature dropped to normal and the results of the direct microscopic examination and culture of fungi in urine turn negative. The itraconazole is effective against F. proliferatum.
The Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, No 12, Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Huilin
H
Su
The Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, No 12, Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Qiangqiang
Q
Zhang
The Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, No 12, Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Li
L
Li
The Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, No 12, Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Ying
Y
Zhao
The Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, No 12, Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Junhao
J
Zhu
The Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, No 12, Middle Urumqi Road, Shanghai, 200040, People's Republic of China. Juneminmyco@126.com.
Min
M
Zhu
D000380:Agranulocytosis / Q000150:complications*; D000935:Antifungal Agents / Q000008:administration & dosage; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D060585:Fusariosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D005670:Fusarium / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D008853:Microscopy; D012004:Rectal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D014556:Urine / Q000382:microbiology
D000935:Antifungal Agents; D004271:DNA, Fungal; D017964:Itraconazole
Agranulocytosis; Fusarium proliferatum; Itraconazole; Urinary tract infection