Vapor Phase Alkyne Coating of Pharmaceutical Excipients: Discrimination Enhancement of Raman Chemical Imaging for Tablets.
Raman chemical imaging has become a powerful analytical tool to investigate the crystallographic characteristics of pharmaceutical ingredients in tablet. However, it is often difficult to discriminate some pharmaceutical excipients from each other by Raman spectrum because of broad and overlapping signals, limiting their detailed assessments. To overcome this difficulty, we developed a vapor phase coating method of excipients by an alkyne, which exhibits a distinctive Raman signal in the range of 2100-2300 cm(-1) . We found that the combination of two volatile reagents, propargyl bromide and triethylamine, formed a thin and nonvolatile coating on the excipient and observed the Raman signal of the alkyne at the surface. We prepared alkyne-coated cellulose by this method and formed a tablet. The Raman chemical imaging of the tablet cross-section using the alkyne peak area intensity of 2120 cm(-1) as the index showed a much clearer particle image of cellulose than using the peak area intensity of 1370 cm(-1) , which originated from the cellulose itself. Our method provides an innovative technique to analyze the solid-state characteristics of pharmaceutical excipients in tablets.
Shujitsu University, School of Pharmacy, Naka-ku, Okayama 703-8516, Japan.
Mayumi
M
Yamashita
Shujitsu University, School of Pharmacy, Naka-ku, Okayama 703-8516, Japan.
Hiroaki
H
Sasaki
Shujitsu University, School of Pharmacy, Naka-ku, Okayama 703-8516, Japan. Electronic address: moriyama@shujitsu.ac.jp.
Kei
K
Moriyama
D000480:Alkynes / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005079:Excipients / Q000737:chemistry*; D010316:Particle Size; D013059:Spectrum Analysis, Raman / Q000379:methods; D013607:Tablets / Q000737:chemistry*
D000480:Alkynes; D005079:Excipients; D013607:Tablets; D002482:Cellulose
Raman spectroscopy; analytical chemistry; excipients; formulation; imaging methods; particle size; preformulation; solid dosage form; solid state; tableting