Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae.
Three new phenolic biphenyl derivatives (1-3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1-4 on rat lens aldose reductase in vitro were examined, and compounds 1-3 markedly inhibited the enzyme with IC50 values of 3.8 to 13.8 μM. In addition, the effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in zebrafish larvae were investigated. Compound 1 was the most effective in reducing HG-induced dilation of hyaloid-retinal vessels.
KM Convergence Research Division, Korea Institute of Oriental Medicine , Daejeon 305-811, Republic of Korea.
Ik-Soo
IS
Lee
KM Convergence Research Division, Korea Institute of Oriental Medicine , Daejeon 305-811, Republic of Korea.
Seung-Hyun
SH
Jung
KM Convergence Research Division, Korea Institute of Oriental Medicine , Daejeon 305-811, Republic of Korea.
Yun Mi
YM
Lee
KM Convergence Research Division, Korea Institute of Oriental Medicine , Daejeon 305-811, Republic of Korea.
So-Jin
SJ
Choi
Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, Yunnan 650204, People's Republic of China.
Hang
H
Sun
KM Convergence Research Division, Korea Institute of Oriental Medicine , Daejeon 305-811, Republic of Korea.
Jin Sook
JS
Kim
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000818:Animals; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005947:Glucose / Q000032:analysis / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D007908:Lens, Crystalline / Q000201:enzymology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D012171:Retinal Vessels / Q000187:drug effects; D027824:Rosaceae / Q000737:chemistry*; D015027:Zebrafish / Q000254:growth & development
C000603539:5'-methoxy-(1,1'-biphenyl)-3,4,3'-triol; C000603540:7S,7'S,8R,8'R-Icariol A2 9'-O-alpha-L-rhamnopyranoside; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D000449:Aldehyde Reductase; D005947:Glucose