Clinical Impact of Epileptiform Discharge in Children With Attention-Deficit/Hyperactivity Disorder (ADHD).
The aim of this study was to investigate the prevalence and clinical significance of epileptiform discharges in patients with attention-deficit/hyperactivity disorder (ADHD). The authors retrospectively reviewed 180 children who were diagnosed with ADHD and had an electroencephalography (EEG) recording. Epileptiform discharges were found in 29 (16.1%) of 180 patients with ADHD. Of these, 15 (8.3%) had generalized epileptiform discharges and 14 (7.7%) had focal epileptiform discharges. The focal epileptiform discharges were most prevalent from the frontal (5/14) and rolandic area (5/14). Among the 29 patients with epileptiform discharges and ADHD, 5 patients had previous history of epilepsy and 4 patients developed epilepsy later, whereas none of the normal EEG group developed epilepsy. The authors suggest that interictal epileptiform discharges appear to be associated with seizure occurrence in children with ADHD and might reflect maturational pathophysiology overlapping with epilepsy.
Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea leeeh80@khmc.or.kr.
Eun Hye
EH
Lee
Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.
Yong Sung
YS
Choi
Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.
Hoi Soo
HS
Yoon
Department of Psychiatry, College of Medicine, Kyung Hee University, Seoul, Korea.
Geon Ho
GH
Bahn
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications* / Q000453:epidemiology; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies
attention-deficit/hyperactivity disorder; cognition; epilepsy; epileptiform discharges; seizure