CD36 deficiency blunts effects of diet on regulatory T cells in murine gonadal adipose tissue and mesenteric lymph nodes.
The effect of cluster of differentiation (CD)36 on regulatory T cells (Treg) was investigated in gonadal (GN) adipose tissues and mesenteric lymph nodes (MLN) of wild-type (WT) and CD36 deficient (CD36(-/-)) mice kept on standard fat (SFD, lean) or on high fat diet (HFD, obese). GN adipose tissue mass was smaller, but MLN size larger for obese CD36(-/-) versus obese WT mice. Overall, the reduction of Treg cells in GN adipose tissue and MLN after a HFD is much more prominent in WT than CD36(-/-) mice. Moreover, CD36(-/-) mice may be protected against obesity-related chronic inflammation.
KU Leuven, University of Leuven, Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, B-3000 Leuven, Belgium.
Lotte
L
Geys
KU Leuven, University of Leuven, Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, B-3000 Leuven, Belgium.
Christine
C
Vranckx
KU Leuven, University of Leuven, Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, B-3000 Leuven, Belgium. Electronic address: roger.lijnen@med.kuleuven.be.
Henri Roger
HR
Lijnen
KU Leuven, University of Leuven, Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, B-3000 Leuven, Belgium.
Ilse
I
Scroyen
D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D018955:CD36 Antigens / Q000172:deficiency / Q000235:genetics*; D059305:Diet, High-Fat; D006066:Gonads / Q000166:cytology; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D008297:Male; D008643:Mesentery / Q000166:cytology / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009765:Obesity / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D018955:CD36 Antigens
Cluster of differentiation 36; FoxP3; Gonadal fat; Mesenteric lymph nodes; Obesity; Regulatory T cells