Elastocapillary Instability in Mitochondrial Fission.
Mitochondria are dynamic cell organelles that constantly undergo fission and fusion events. These dynamical processes, which tightly regulate mitochondrial morphology, are essential for cell physiology. Here we propose an elastocapillary mechanical instability as a mechanism for mitochondrial fission. We experimentally induce mitochondrial fission by rupturing the cell's plasma membrane. We present a stability analysis that successfully explains the observed fission wavelength and the role of mitochondrial morphology in the occurrence of fission events. Our results show that the laws of fluid mechanics can describe mitochondrial morphology and dynamics.
Laboratoire d'Hydrodynamique, Ecole Polytechnique, CNRS UMR 7646, 91128 Palaiseau, France.
David
D
Gonzalez-Rodriguez
Laboratoire d'Hydrodynamique, Ecole Polytechnique, CNRS UMR 7646, 91128 Palaiseau, France.
Sébastien
S
Sart
Laboratoire d'Hydrodynamique, Ecole Polytechnique, CNRS UMR 7646, 91128 Palaiseau, France.
Avin
A
Babataheri
Institut Jacques Monod, Université Paris Diderot, INSERM U950, CNRS UMR 7592, 75205 Paris, France.
David
D
Tareste
Laboratoire d'Hydrodynamique, Ecole Polytechnique, CNRS UMR 7646, 91128 Palaiseau, France.
Abdul I
AI
Barakat
Laboratoire d'Hydrodynamique, Ecole Polytechnique, CNRS UMR 7646, 91128 Palaiseau, France.
Christophe
C
Clanet
Laboratoire d'Hydrodynamique, Ecole Polytechnique, CNRS UMR 7646, 91128 Palaiseau, France.
Julien
J
Husson
D000818:Animals; D002417:Cattle; D004548:Elasticity; D042783:Endothelial Cells / Q000166:cytology; D008928:Mitochondria / Q000737:chemistry / Q000502:physiology*; D063154:Mitochondrial Dynamics / Q000502:physiology*; D008954:Models, Biological