HIF-1α and growth plate development: what we really know.
Adaptation to low oxygen tension or hypoxia is a critical event in development and tissue homeostasis. Studies by us and others have shown that the fetal growth plate is an avascular tissue with a gradient of oxygenation, and the transcription factor hypoxia-inducible factor-1α (HIF-1α) is essential for its development. In this brief review, we will summarize our current understanding of the role of HIF-1α in fetal growth plate development, and we will discuss yet unanswered questions in the field of hypoxia and endochondral bone formation.
Department of Orthopaedic Surgery, Department of Medicine, Division of Endocrinology and Department of Cell and Developmental Biology, University of Michigan, Medical School, A. Alfred Taubman Biomedical Science Research Bldg , Ann Arbor, MI, USA.
Ernestina
E
Schipani
Department of Orthopaedic Surgery, Department of Medicine, Division of Endocrinology and Department of Cell and Developmental Biology, University of Michigan, Medical School, A. Alfred Taubman Biomedical Science Research Bldg , Ann Arbor, MI, USA.
Laura
L
Mangiavini
Department of Orthopaedic Surgery, Department of Medicine, Division of Endocrinology and Department of Cell and Developmental Biology, University of Michigan, Medical School, A. Alfred Taubman Biomedical Science Research Bldg , Ann Arbor, MI, USA ; Inserm, UMRS 791-LIOAD, Centre for Osteoarticular and Dental Tissue Engineering, Group STEP 'Skeletal Tissue Engineering and Physiopathology' , Nantes, France ; LUNAM, Nantes University, Faculty of Dental Surgery , Nantes, France.
Christophe
C
Merceron