[Metastasis and progression mechanisms of soft tissue tumors].
Invasion and metastatic dissemination of tumor cells defines prognosis not only in patients with epithelial, but also mesenchymal neoplasms. Early and clinically inapparent micrometastases occur in many patients, and the risk for metastasis correlates with the tumor subtype and histologic tumor grade. In recent years and analogous to the situation in epithelial tumors, mechanisms of tumor cell dissemination in soft tissue tumors have been increasingly understood, and it has been shown that reorganization of the actin cytoskeleton plays a key role in these processes. This review summarizes current knowledge on the mechanisms of progression and metastasis of soft tissue tumors and points out possible targets for novel anti-invasive and anti-metastatic therapies.
Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Domagkstr. 17, 48149, Münster, Deutschland.
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Steinestel
Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Domagkstr. 17, 48149, Münster, Deutschland. eva.wardelmann@ukmuenster.de.
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Wardelmann
D018450:Disease Progression; D006801:Humans; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000517:prevention & control; D009362:Neoplasm Metastasis / Q000473:pathology* / Q000628:therapy; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D012509:Sarcoma / Q000473:pathology / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000628:therapy
Actin; Invasion; Neoplasm grading; Neoplasm recurrence; Sarcoma