Scalable Synthesis of Piperazines Enabled by Visible-Light Irradiation and Aluminum Organometallics.
The development of more active C-H oxidation catalysts has inspired a rapid, scalable, and stereoselective assembly of multifunctional piperazines through a [3+3] coupling of azomethine ylides. A combination of visible-light irradiation and aluminum organometallics is essential to promote this transformation, which introduces visible-light photochemistry of main-group organometallics and sets the basis for new and promising catalysts.
Department of Organic Chemistry and Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 10691 Stockholm (Sweden) http://www.organ.su.se/am/
Samuel
S
Suárez-Pantiga
Department of Organic Chemistry and Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 10691 Stockholm (Sweden) http://www.organ.su.se/am/
Kilian
K
Colas
Innovative Medicines, Cardiovascular and Metabolic Diseases, Medicinal Chemistry, AstraZeneca R&D, Pepparedsleden 1, 43183 Mölndal (Sweden).
Magnus J
MJ
Johansson
Department of Organic Chemistry and Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 10691 Stockholm (Sweden) http://www.organ.su.se/am/. abraham.mendoza@su.se.
Abraham
A
Mendoza
aluminum; cycloaddition; heterocycles; oxidation; photochemistry