2,2,2-Trifluoroethyl Chlorooxoacetate--Universal Reagent for One-Pot Parallel Synthesis of N(1)-Aryl-N(2)-alkyl-Substituted Oxamides.
A one-pot parallel synthesis of N(1)-aryl-N(2)-alkyl-substituted oxamides with 2,2,2-trifluoroethyl chlorooxoacetate was developed. The synthesis of a library of 45 oxamides revealed higher efficiency of this reagent over the known ethyl chlorooxoacetate. The reagent was successfully used to prepare the known oxamide-containing HIV entry inhibitors.
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.
Andrey V
AV
Bogolubsky
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.|ChemBioCenter, Kyiv National Taras Shevchenko University , 61 Chervonotkatska Street, Kyiv, 02094, Ukraine.
Yurii S
YS
Moroz
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.|Department of Chemistry, Kyiv National Taras Shevchenko University , 64 Volodymyrska Street, Kyiv, 01601, Ukraine.
Pavel K
PK
Mykhailiuk
ChemBioCenter, Kyiv National Taras Shevchenko University , 61 Chervonotkatska Street, Kyiv, 02094, Ukraine.
Sergey E
SE
Pipko
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.
Anton V
AV
Zhemera
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.|The Institute of High Technologies, Kyiv National Taras Shevchenko University , 4 Glushkov Street, Building 5, Kyiv, 03187, Ukraine.
Anzhelika I
AI
Konovets
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.|National Technical University of Ukraine "Kyiv Politechnic Institute" , 37 Peremohy Avenue, Kyiv, 03056, Ukraine.
Olena O
OO
Stepaniuk
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.|National Technical University of Ukraine "Kyiv Politechnic Institute" , 37 Peremohy Avenue, Kyiv, 03056, Ukraine.
Inna S
IS
Myronchuk
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.
Yurii V
YV
Dmytriv
Department of Chemistry, Kyiv National Taras Shevchenko University , 64 Volodymyrska Street, Kyiv, 01601, Ukraine.
Roman A
RA
Doroschuk
Department of Chemistry, Kyiv National Taras Shevchenko University , 64 Volodymyrska Street, Kyiv, 01601, Ukraine.
Olga A
OA
Zaporozhets
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.|ChemBioCenter, Kyiv National Taras Shevchenko University , 61 Chervonotkatska Street, Kyiv, 02094, Ukraine.
Andrey
A
Tolmachev
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D006038:Glyoxylates / Q000737:chemistry*; D023581:HIV Fusion Inhibitors / Q000138:chemical synthesis; D007202:Indicators and Reagents; D010070:Oxalates / Q000737:chemistry*; D054852:Small Molecule Libraries
C000609213:2,2,2-trifluoroethyl chlorooxoacetate; D000577:Amides; D000588:Amines; D006038:Glyoxylates; D023581:HIV Fusion Inhibitors; D007202:Indicators and Reagents; D010070:Oxalates; D054852:Small Molecule Libraries
2,2,2-trifluoroethyl chlorooxoacetate; N1-aryl-N2-alkyl-substituted oxamides; ethyl chlorooxoacetate; one-pot approach; parallel synthesis