Ru (II)-Catalyzed C-H Activation: Ketone-Directed Novel 1,4-Addition of Ortho C-H Bond to Maleimides.
A 1,4-addition with the nucleophilic center generated at the ortho carbon atom of an aromatic ketone in the presence of the highly reactive α-C-H bond, using a directing group strategy, is presented. The reaction yields pharmaceutically useful 3-arylated succinimide derivatives. In order to gain understanding of this redox neutral reaction, despite the presence of copper acetate, and to substantiate the lack of Heck-type products, DFT calculations have been carried out.
Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka, India.
Kiran R
KR
Bettadapur
Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka, India.
Veeranjaneyulu
V
Lanke
Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka, India.
Kandikere Ramaiah
KR
Prabhu