[Ultrasmall nanoparticles for radiotherapy: AGuIX].
Since twenty years, many nanoparticles based on high atomic number elements have been developed as radiosensitizers. The design of these nanoparticles is limited by the classical rules associated with the development of nanoparticles for oncology and by the specific ones associated to radiosensitizers, which aim to increase the effect of the dose in the tumor area and to spare the health tissues. For this application, systemic administration of nanodrugs is possible. This paper will discuss the development of AGuIX nanoparticles and will emphasize on this example the critical points for the development of a nanodrug for this application. AGuIX nanoparticles display hydrodynamic diameters of a few nanometers and are composed of polysiloxane and gadolinium chelates. This particle has been used in many preclinical studies and is evaluated for a further phase I clinical trial. Finally, in addition to its high radiosensitizing potential, AGuIX display MRI functionality and can be used as theranostic nanodrug for personalized medicine.
UMR 5306, institut lumière matière, université Lyon-1, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France; UMR 5306, CNRS, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France.
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UMR 5306, institut lumière matière, université Lyon-1, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France; UMR 5306, CNRS, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France; Nano-H SAS, 2, place de l'Europe, 38070 Saint-Quentin Fallavier, France.
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Nano-H SAS, 2, place de l'Europe, 38070 Saint-Quentin Fallavier, France.
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Dufort
UMR 5306, institut lumière matière, université Lyon-1, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France; UMR 5306, CNRS, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France.
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Sancey
Nano-H SAS, 2, place de l'Europe, 38070 Saint-Quentin Fallavier, France.
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Louis
UMR 5306, institut lumière matière, université Lyon-1, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France; UMR 5306, CNRS, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France; Nano-H SAS, 2, place de l'Europe, 38070 Saint-Quentin Fallavier, France.
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UMR 5306, institut lumière matière, université Lyon-1, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France; UMR 5306, CNRS, 2, rue Victor-Grignard, 69622 Villeurbanne cedex, France. Electronic address: olivier.tillement@univ-lyon1.fr.
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Tillement
D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use
D011838:Radiation-Sensitizing Agents
IRM; MRI; Nanoparticles; Nanoparticules; Radiotherapy; Radiothérapie; Theranostic; Théranostique