Simvastatin protects the heart against ischemia reperfusion injury via inhibiting HMGB1 expression through PI3K/Akt signal pathways.
Department of Cardiology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, PR China.
Qian-Feng
QF
Han
Department of Cardiology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, PR China.
Lei
L
Wu
Department of Cardiology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, PR China.
Yan-Hong
YH
Zhou
Department of Cardiology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, PR China.
Lan-Hua
LH
Wang
Department of Cardiology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, PR China.
De-Yong
DY
Zhang
Department of Cardiology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, PR China.
Tao
T
Liu
Department of Cardiology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, PR China. Electronic address: yaohc66@126.com.
Heng-Chen
HC
Yao
D004247:DNA / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005786:Gene Expression Regulation / Q000187:drug effects*; D024243:HMGB1 Protein / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000235:genetics / Q000517:prevention & control; D019869:Phosphatidylinositol 3-Kinases / Q000096:biosynthesis / Q000235:genetics*; D051057:Proto-Oncogene Proteins c-akt / Q000096:biosynthesis / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects; D019821:Simvastatin / Q000008:administration & dosage*
D024243:HMGB1 Protein; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D004247:DNA; D019821:Simvastatin; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt