[Genetic variability and phylogenetic analysis of 39 short tandem repeat loci in Beijing Han population].
In this study, we studied the genetic polymorphisms of short tandem repeat (STR) loci from 13 CODIS and 26 non-CODIS system in Beijing Han population for the first time, and established a database of 39 STR loci whose forensic parameters were further evaluated. Our results demonstrated no significant deviation from the Hardy-Weinberg equilibrium of 39 STR loci and no pairwise linkage disequilibrium between them. The power of discriminations, expected heterozygosity, polymorphic information content, and power of exclusion of 39 STR loci ranged from 0.7740-0.9818, 0.6000-0.9350, 0.5317-0.9047 and 0.2909-0.8673. The cumulated discrimination power and cumulative probability of exclusion were 0.999999999999999999999999999999999999999964971 and 0.999999999973878, respectively. Moreover, the genetic distance was calculated based on allele frequency and phylogenetic tree was built using STR loci data from Beijing Han and other 11 Chinese ethnic groups.This study provides important basic data for Chinese forensic DNA database and population genetics database, and has important significance in carrying out forensic individual identification, paternity testing, and population genetic study.
Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Xiu-yan
X
Ruan
Shenzhen Criminal Science and Technology Institute, Shenzhen 518001, China.
Wei-ni
WN
Wang
Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Ya-ran
YR
Yang
1. Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; 2. University of Chinese Academy of Sciences, Beijing 100049, China;
Bing-bing
BB
Xie
Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Jing
J
Chen
Forensic Science Division, Department of Beijing Public Security, Beijing 100192, China.
Ya-cheng
YC
Liu
Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Jiang-wei
JW
Yan
D002681:China / Q000208:ethnology; D014644:Genetic Variation; D006801:Humans; D018895:Microsatellite Repeats; D010802:Phylogeny