The short-term and long-term adverse ocular effects of fesoterodine fumarate.
OBJECTIVE
To evaluate the short-term and long-term effects of fesoterodine fumarate treatment which is used for overactive bladder (OAB) on pupil diameter (PD), intraocular pressure (IOP) and accommodation amplitude (AA).


METHODS
Ophthalmic examination was performed before and after receiving medication (on the 30th and 90th day) on 120 eyes of 120 women whom were planned to begin anticholinergic treatment (fesoterodine fumarate, 4 mg/day, peroral) for OAB, prospectively. The changes in PD, IOP and AA were analyzed statistically.


RESULTS
The mean age of 120 women was 52.06 ± 9.39 years (30-70 years). The mean PD, IOP and AA values were 4.12 ± 0.61 mm (3.00-5.70 mm), 15.58 ± 1.74 mmHg (11-20 mmHg) 2.28 ± 1.26 Diopter (D) (0.50-5.50 D) at baseline; 4.68 ± 0.65 mm (3.20-5.80 mm), 16.11 ± 1.72 mmHg (11-20 mmHg), 1.68 ± 1.04 D (0.25-4.50 D) at 30th day; and 4.28 ± 0.58 mm (3.10-5.70 mm), 16.09 ± 1.96 mmHg (11-19 mmHg), 2.18 ± 1.19 D (0.50-5.00 D) at 90th day, respectively. Although increases in PD values and decreases in AA values were statistically significant (p < 0.001 for each), the changes in IOP values were not as such (p = 0.642). Visual complaint was not observed in any patient.


CONCLUSIONS
The newest anticholinergic medication in women with OAB increased the PD and decreased the AA statistically significantly. Clinically, it seems to be well-tolerated by the patient.
a Department of Ophthalmology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
Damla
D
Erginturk Acar
b Department of Ophthalmology , Hacettepe University, Faculty of Medicine , Ankara , Turkey , and.
Ugur
U
Acar
a Department of Ophthalmology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
Ozdemir
O
Ozdemir
a Department of Ophthalmology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
Zuhal
Z
Ozen Tunay
c Department of Urogynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
Sabri
S
Cavkaytar
D000065:Accommodation, Ocular / Q000187:drug effects; D000328:Adult; D000368:Aged; D001559:Benzhydryl Compounds / Q000009:adverse effects*; D005123:Eye / Q000033:anatomy & histology / Q000187:drug effects*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000009:adverse effects*; D016037:Single-Blind Method; D014065:Tonometry, Ocular; D053201:Urinary Bladder, Overactive / Q000188:drug therapy; D064804:Urological Agents / Q000009:adverse effects*
D001559:Benzhydryl Compounds; D018727:Muscarinic Antagonists; D064804:Urological Agents; C526675:fesoterodine
Accommodation amplitude; fesoterodine fumarate; intraocular pressure; overactive bladder; pupil diameter