Microvascular complications and prevalence of urgency incontinence in Japanese patients with type 2 diabetes mellitus: The dogo study.
Diabetes was significantly positively associated with urgency incontinence in several epidemiological studies. We examine the association between diabetic neuropathy, which we defined based on neuropathic symptoms, the absence of the Achilles reflex, and/or abnormal vibration perception, and urgency incontinence among Japanese patients with type 2 diabetes mellitus.



Study subjects were 742 Japanese patients with type 2 diabetes mellitus, aged 19-70 years, who had undergone blood tests at our institutions. A self-administered questionnaire was used to collect information on the variables under study. Urgency incontinence was defined as present when a subject answered "once a week or more" to the question: "Within one week, how often do you leak urine because you cannot defer the sudden desire to urinate ?". Diabetic neuropathy was diagnosed if the patients showed two or more of the following three characteristics: neuropathic symptoms, the absence of the Achilles reflex, and/or abnormal vibration perception. Adjustment was made for sex, age, body mass index, duration of type 2 diabetes mellitus, current smoking, hypertension, dyslipidemia, glycated hemoglobin, stroke, coronary artery disease, insulin therapy, diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy.



The prevalence of urgency incontinence was 8.6%. Diabetic neuropathy was independently positively associated with urgency incontinence: the adjusted OR was 2.20 (95%CI: 1.16-4.36). Associations between diabetic retinopathy or nephropathy and the prevalence of urgency incontinence were not significant.



In Japanese patients with type 2 diabetes mellitus, only diabetic neuropathy was independently positively associated with urgency incontinence. Neurourol. Urodynam. 35:1024-1027, 2016. © 2015 Wiley Periodicals, Inc.
Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. shinya.furukawa@gmail.com.
Shinya
S
Furukawa
Department of Internal Medicine, Yawatahama General City Hospital, Yawatahama, Ehime, Japan.
Takenori
T
Sakai
Department of Internal Medicine, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan.
Tetsuji
T
Niiya
Department of Internal Medicine, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan.
Hiroaki
H
Miyaoka
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Teruki
T
Miyake
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Shin
S
Yamamoto
Department of Public Health, Juntendo University School of Medicine, Hongo, Tokyo, Japan.
Koutatsu
K
Maruyama
Department of Internal Medicine, Ehime Central Hospital, Matsuyama, EHime, Japan.
Teruhisa
T
Ueda
Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.|Department of Internal Medicine, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan.
Hidenori
H
Senba
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Yasuhiko
Y
Todo
Department of Internal Medicine, Saiseikai Saijo Hospital, Saijo, Ehime, Japan.
Masamoto
M
Torisu
Department of Internal Medicine, Ehime Niihama Hospital, Niihama, Ehime, Japan.
Hisaka
H
Minami
Department of Internal Medicine, Saiseikai Imabari Hospital, Imabari, Ehime, Japan.
Morikazu
M
Onji
Department of Public Health, Juntendo University School of Medicine, Hongo, Tokyo, Japan.
Takeshi
T
Tanigawa
Department of Lifestyle-Related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Bunzo
B
Matsuura
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Yoichi
Y
Hiasa
Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Yoshihiro
Y
Miyake
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology*; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D003928:Diabetic Nephropathies / Q000150:complications / Q000453:epidemiology; D003929:Diabetic Neuropathies / Q000150:complications / Q000453:epidemiology; D003930:Diabetic Retinopathy / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009460:Neurologic Examination; D015995:Prevalence; D011446:Prospective Studies; D053202:Urinary Incontinence, Urge / Q000453:epidemiology*; D055815:Young Adult
diabetes; incontinence; microvascular complications; neuropathy