Survival of the Fittest: Competitive Co-crystal Reactions in the Ball Mill.
The driving forces triggering the formation of co-crystals under milling conditions were investigated by using a set of multicomponent competitive milling reactions. In these reactions, different active pharmaceutical ingredients were ground together with a further compound acting as coformer. The study was based on new co-crystals including the coformer anthranilic acid. The results of the competitive milling reactions indicate that the formation of co-crystals driven by intermolecular recognition are influenced and inhibited by kinetic aspects including the formation of intermediates and the stability of the reactants.
BAM Federal Institute for Materials Research and Testing, R.-Willstätter-Strasse 11, 12489 Berlin (Germany).|Department of Chemistry, Humboldt-Universität zu Berlin, B.-Taylor-Strasse 2, 12489 Berlin (Germany).
Franziska
F
Fischer
BAM Federal Institute for Materials Research and Testing, R.-Willstätter-Strasse 11, 12489 Berlin (Germany).|Department of Chemistry, Humboldt-Universität zu Berlin, B.-Taylor-Strasse 2, 12489 Berlin (Germany).
Maike
M
Joester
Department of Chemistry, Humboldt-Universität zu Berlin, B.-Taylor-Strasse 2, 12489 Berlin (Germany).
Klaus
K
Rademann
BAM Federal Institute for Materials Research and Testing, R.-Willstätter-Strasse 11, 12489 Berlin (Germany). franziska.emmerling@bam.de.
Franziska
F
Emmerling
X-ray diffraction; crystal engineering; kinetics; mechanochemistry; structure determination