Biomedical Probes Based on Inorganic Nanoparticles for Electrochemical and Optical Spectroscopy Applications.
Inorganic nanoparticles usually provide novel and unique physical properties as their size approaches nanometer scale dimensions. The unique physical and optical properties of nanoparticles may lead to applications in a variety of areas, including biomedical detection. Therefore, current research is now increasingly focused on the use of the high surface-to-volume ratios of nanoparticles to fabricate superb chemical- or biosensors for various detection applications. This article highlights various kinds of inorganic nanoparticles, including metal nanoparticles, magnetic nanoparticles, nanocomposites, and semiconductor nanoparticles that can be perceived as useful materials for biomedical probes and points to the outstanding results arising from their use in such probes. The progress in the use of inorganic nanoparticle-based electrochemical, colorimetric and spectrophotometric detection in recent applications, especially bioanalysis, and the main functions of inorganic nanoparticles in detection are reviewed. The article begins with a conceptual discussion of nanoparticles according to types, followed by numerous applications to analytes including biomolecules, disease markers, and pharmaceutical substances. Most of the references cited herein, dating from 2010 to 2015, generally mention one or more of the following characteristics: a low detection limit, good signal amplification and simultaneous detection capabilities.
Electrochemistry and Optical Spectroscopy Research Unit (EOSRU), Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Patumwan, Bangkok 10330, Thailand. i_style@windowslive.com.
Abdulhadee
A
Yakoh
Electrochemistry and Optical Spectroscopy Research Unit (EOSRU), Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Patumwan, Bangkok 10330, Thailand. n8h7@hotmail.com.
Chanika
C
Pinyorospathum
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand. weenasi@hotmail.com.
Weena
W
Siangproh
Electrochemistry and Optical Spectroscopy Research Unit (EOSRU), Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Patumwan, Bangkok 10330, Thailand. corawon@chula.ac.th.
Orawon
O
Chailapakul
D015374:Biosensing Techniques / Q000379:methods*; D003124:Colorimetry; D004298:Dopamine / Q000097:blood; D055664:Electrochemical Techniques / Q000379:methods*; D006046:Gold; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*
D006046:Gold; D004298:Dopamine
bioanalysis; biomedical probes; biosensors; colorimetry; electrochemical detection; inorganic nanoparticles; spectrophotometric detection