Contraceptive practices and cervical screening in women with cystic fibrosis.
OBJECTIVE
Is gynaecological management of women with cystic fibrosis (CF) adequate?


CONCLUSIONS
Gynaecological care (frequency of follow-up, cervical screening and contraceptive use among sexually active women) in women with CF fails to reach the recommended level.


BACKGROUND
Little is known about gynaecological follow-up and cervical screening in CF. Only few studies have described contraceptive practices in cohorts of CF women.


METHODS
We did a cross-sectional study in a cohort of 155 CF women attending the Lyon adult centre. Women attending the CF adult centre in 2014 completed a written questionnaire about their contraceptive choices, frequency of gynaecological follow-up and cervical screening. Other clinical data were collected from the CF adult centre registry.


METHODS
One hundred and twenty women (100%) answered the questionnaire, among whom two were post-menopausal (46 and 59 years of age), and five were pregnant.


RESULTS
Seventy-four per cent of the women declared they had undergone gynaecological follow-up (89% of the women with transplantation), and only 55% reported having at least one previous Pap smear test. Among the transplanted patients, only 58% had had a Pap smear test, despite immunosuppressive treatment. The overall rate of contraception was only 64% and in diabetic women, it was 61%. Among contraception users; 65% used oral contraception, predominantly combined estrogen-progestagen (47%); among diabetic patients, 26% used progestin-only contraception. Intrauterine device accounted for 10% of patients using contraception, and tubal ligation only 4%.


CONCLUSIONS
This study is limited by its cross-sectional design. Despite an internal validation of the questionnaire showing an almost perfect agreement, the risk of recall bias has to be taken into account.


CONCLUSIONS
This study of practices highlights the importance of improved information regarding sexuality, fertility and reproductive health in young women with CF. A regular gynaecological follow-up and cervical screening is mandatory in this population. Better gynaecological care and contraceptive advice would help to avoid unplanned pregnancies, and optimize contraceptive selection in relationship to specific clinical conditions.
Cystic Fibrosis Adult Referral Centre, Department of Internal Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Benite Cedex, France Department of Obstetrics and Gynecology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Benite Cedex, France Department of Surgical Oncology, Centre Léon Bérard, 28 rue Laënnec, 69008 Lyon, France christine.rousset-jablonski@chu-lyon.fr.
C
C
Rousset Jablonski
Cystic Fibrosis Adult Referral Centre, Department of Internal Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Benite Cedex, France Lyon 1 Claude Bernard University, Lyon, France.
Q
Q
Reynaud
Cystic Fibrosis Adult Referral Centre, Department of Internal Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Benite Cedex, France.
M
M
Perceval
Cystic Fibrosis Adult Referral Centre, Department of Internal Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Benite Cedex, France.
R
R
Nove-Josserand
Cystic Fibrosis Adult Referral Centre, Department of Internal Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Benite Cedex, France.
S
S
Durupt
Cystic Fibrosis Adult Referral Centre, Department of Internal Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Benite Cedex, France Lyon 1 Claude Bernard University, Lyon, France.
J C
JC
Lega
Cystic Fibrosis Adult Referral Centre, Department of Internal Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Benite Cedex, France Lyon 1 Claude Bernard University, Lyon, France.
I
I
Durieu
D000293:Adolescent; D000328:Adult; D003267:Contraception / Q000706:statistics & numerical data*; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test / Q000706:statistics & numerical data*; D002577:Uterine Cervical Diseases / Q000175:diagnosis*; D055815:Young Adult
Pap smear; contraception; counselling; cystic fibrosis; gynaecological follow-up; screening