Site-Selective Addition of Maleimide to Indole at the C-2 Position: Ru(II)-Catalyzed C-H Activation.
Synthesis of 3-(indol-2-yl)succinimide derivatives is presented using a directing group strategy. Selective functionalization of C-2 in the presence of highly reactive C-3 in indole derivatives has been achieved. A conjugate addition product instead of Heck-type product has been brought about by careful selection of the alkene partner (maleimides and maleate esters) such that a β-hydride elimination is avoided.
Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka, India.
Veeranjaneyulu
V
Lanke
Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka, India.
Kiran R
KR
Bettadapur
Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka, India.
Kandikere Ramaiah
KR
Prabhu