The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients.
A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) and IL17F T7488C (rs763780) polymorphisms and periodontitis. Genotypes were determined by PCR-RFLP method. Statistical analyses were conducted using the OpenEpi and SNPStas software to calculate Chi-square with Yates correction or Fisher's exact tests, odds ratios (OR), and 95% confidence intervals (CIs). SNPStas software was used to calculate Hardy-Weinberg equilibrium. IL17A AA genotype was more frequent in patients with chronic periodontitis (CP) in the codominant and recessive models (P = 0.09; OR = 2.53 and P = 0.03; OR = 2.46, resp.), the females with CP (P = 0.01, OR = 4.34), Caucasoid patients with CP (P = 0.01, OR = 3.45), and nonsmoking Caucasian patients with CP (P = 0.04, OR = 3.51). The IL17A A allele was also more frequent in Caucasians with CP (P = 0.04, OR = 1.59). IL17F T7488C polymorphism was not associated with chronic periodontitis. In these patients from Southern Brazil, the IL17A rs2275913 polymorphisms, IL17A AA genotype, and the A allele were associated with a susceptibility to chronic periodontitis.
Post Graduation Program of Biosciences and Physiopathology, Biomedicine and Clinical Analysis Department, Maringá State University, 87020-900 Maringá, PR, Brazil.
Joana Maira Valentini
JM
Zacarias
Post Graduation Program of Biosciences and Physiopathology, Biomedicine and Clinical Analysis Department, Maringá State University, 87020-900 Maringá, PR, Brazil.
Emília Ângela
EÂ
Sippert
Biomedicine and Clinical Analysis Department, Maringá State University, 87020-900 Maringá, PR, Brazil.
Patrícia Yumeko
PY
Tsuneto
Basic Health Sciences Department, Maringá State University, 87020-900 Maringá, PR, Brazil.
Jeane Eliete Laguila
JE
Visentainer
Dentistry Department, Maringá State University, 87020-900 Maringá, PR, Brazil.
Cléverson
C
de Oliveira e Silva
Basic Health Sciences Department, Maringá State University, 87020-900 Maringá, PR, Brazil.
Ana Maria
AM
Sell
D000328:Adult; D001938:Brazil / Q000453:epidemiology; D055113:Chronic Periodontitis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17