Novel multifunctional colloidal carbohydrate nanofiber electrolytes with excellent conductivity and responses to bone cancer cells.
This work presents a new approach to fabricating novel polymer nanofiber composites (NFCs) from water solution blends of PVA (hydrolyzed 89%)/ODA-MMT and Na-CMC/ODA-MMT nanocomposites as well as their folic acid (FA) incorporated modifications (NC-3-FA and NC-4-FA) through green electrospinning nanotechnology. The chemical and physical structures and surface morphology of the nanofiber composites were confirmed. Significant improvements in nanofiber morphology and size distribution of the NFC-3-FA and NFC-4-FA nanofibers with lower average means 110 and 113nm compared with those of NFC-1/NFC-2 nanofibers (270 and 323nm) were observed. The structural elements of polymer NFCs, particularly loaded partner NC-2, plays an important role in chemical and physical interfacial interactions, phase separation processing and enables the formation of nanofibers with unique morphology and excellent conductivity (NFC-3-FA 3.25×10(-9)S/cm and NFC-4-FA 8.33×10(-4)S/cm). This is attributed to the higher surface contact areas and multifunctional self-assembled supramacromolecular nanostructures of amorphous colloidal electrolytes. The anticancer activity of FA-containing nanofibers against osteocarcinoma cells were evaluated by cytotoxicity, apoptotic and necrotic analysis methods.
Department of Chemistry, Faculty of Science, Hacettepe University, Beytepe Campus, 06800 Ankara, Turkey.
Fatma Özge
FÖ
Gökmen
The Institute of Science & Engineering, Division of Nanotechnology and Nanomedicine, Hacettepe University, Beytepe Campus, 06800 Ankara, Turkey. Electronic address: zmo@hacettepe.edu.tr.
Zakir M O
ZM
Rzayev
Department of Chemical Engineering, Faculty of Engineering, Hacettepe University, Beytepe Campus, 06800 Ankara, Turkey.
Kouroush
K
Salimi
Department of Biomedical Engineering, Faculty of Engineering, Baskent University, Baglica Campus, 06810 Ankara, Turkey.
Ulviya
U
Bunyatova
Department of Physics, Faculty of Science, Gazi University, Besevler, 06500 Ankara, Turkey.
Selim
S
Acar
Department of Physics, Faculty of Science, Gazi University, Besevler, 06500 Ankara, Turkey.
Bahtiyar
B
Salamov
Department of Biology, Division of Bioengineering, Kirikkale University, 71450 Kirikkale, Turkey.
Mustafa
M
Türk
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001859:Bone Neoplasms / Q000473:pathology*; D002241:Carbohydrates / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003102:Colloids; D004553:Electric Conductivity; D004573:Electrolytes / Q000737:chemistry*; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry; D013499:Surface Properties
D000970:Antineoplastic Agents; D002241:Carbohydrates; D003102:Colloids; D004573:Electrolytes; D011142:Polyvinyl Alcohol
Bone cancer cells; Conductivity; Electrospinning; Morphology; Na-CMC; Nanocomposites; Nanofibers; Organoclay; PVA; Structure–property relationships