[Gastroparesis and other gastrointestinal symptoms in Parkinson's disease].
Different gastrointestinal symptoms, such as excessive salivation, deterioration and other disorders affecting the teeth, dysphagia, gastroparesis, gastroesophageal reflux, constipation, difficult defecation or loss of weight are frequent events in all the stages of the development of Parkinson's disease and affect at least a third of the patients. These symptoms reflect the dysfunction of the enteric nervous system, and the stomach is one of the organs where alpha-synuclein is first deposited. Other factors, such as the dysfunction of structures in the central nervous system like the dorsal motor nucleus of the vagal nerve, hormonal factors or secondary effects deriving from the consumption of antiparkinsonian drugs, are involved in its origin. The present article offers a detailed review of the epidemiological, pathophysiological, clinical and therapeutic management aspects of the different gastrointestinal symptoms in Parkinson's disease.
Complejo Hospitalario Arquitecto Marcide - Profesor Novoa Santos, 15405 El Ferrol, Espana.
D
D
Santos-Garcia
T
T
de Deus
C
C
Tejera-Perez
I
I
Exposito-Ruiz
E
E
Suarez-Castro
P
P
Carpintero
M
M
Macias-Arribi
D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D002012:Bruxism / Q000209:etiology / Q000503:physiopathology; D015897:Comorbidity; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology; D004066:Digestive System Diseases / Q000209:etiology* / Q000503:physiopathology; D017615:Enteric Nervous System / Q000503:physiopathology*; D005768:Gastrointestinal Hormones / Q000378:metabolism; D018589:Gastroparesis / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D044342:Malnutrition / Q000209:etiology; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D012798:Sialorrhea / Q000209:etiology / Q000503:physiopathology; D063189:Symptom Assessment; D014630:Vagus Nerve / Q000503:physiopathology; D015431:Weight Loss
D000978:Antiparkinson Agents; D005768:Gastrointestinal Hormones