New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients.
Leprosy control is achieved through a fine-tuning of TH1 and TH2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.
Hospital Israelita Albert Einstein, Instituto Israelita de Ensino e Pesquisa, São Paulo, Brazil.
Pedro Henrique
PH
Papotto
Universidade Federal de São Paulo, Dermatology Department, São Paulo, Brazil.
Solange
S
Maeda
Universidade Federal de São Paulo, Dermatology Department, São Paulo, Brazil.
Jane
J
Tomimori
Universidade Federal do Pará, Dermatology Department, Pará, Brazil.
Marília Brasil
MB
Xavier
Hospital Israelita Albert Einstein, Instituto Israelita de Ensino e Pesquisa, São Paulo, Brazil.
Luiz Vicente
LV
Rizzo
Universidade de São Paulo, Faculdade de Medicina, Disciplina de Imunologia Clínica e Alergia (LIM60), São Paulo, Brazil.
Esper Georges
EG
Kallas
Hospital Israelita Albert Einstein, Instituto Israelita de Ensino e Pesquisa, São Paulo, Brazil.
Karina Inácio
KI
Carvalho
D000328:Adult; D060085:Coinfection / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007918:Leprosy / Q000150:complications* / Q000276:immunology* / Q000382:microbiology; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000276:immunology; D055815:Young Adult