Adult hippocampal neurogenesis and pattern separation in DG: a role for feedback inhibition in modulating sparseness to govern population-based coding.
The dentate gyrus (DG) of mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life. Behavioral studies using the contextual fear discrimination paradigm have found that selectively augmenting or blocking adult hippocampal neurogenesis enhances or impairs discrimination under conditions of high, but not low, interference suggestive of a role in pattern separation. Although contextual discrimination engages population-based coding mechanisms underlying pattern separation such as global remapping in the DG and CA3, how adult hippocampal neurogenesis modulates pattern separation in the DG is poorly understood. Here, we propose a role for adult-born DGCs in re-activation coupled modulation of sparseness through feed-back inhibition to govern global remapping in the DG.
Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA.
Kathleen
K
McAvoy
Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA.
Antoine
A
Besnard
Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA ; Harvard Stem Cell Institute, Harvard University Cambridge, MA, USA ; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA.
Amar
A
Sahay
adult hippocampal neurogenesis; dentate gyrus; discrimination; feed-back inhibition; generalization; interference; pattern separation; sparseness