A meta-analysis of Shenqi Fuzheng combined with radiation in the treatment of nonsmall cell lung cancer.
OBJECTIVE
The objective of this study is to evaluate the efficacy and toxicity reduction of Shenqi Fuzheng injection in the treatment of nonsmall cell lung cancer (NSCLC).


METHODS
Through searching the PubMed, WANFANG and CNKI, we recruited clinical trials related to Shenqi Fuzheng combined with radiation in the treatment of NSCLC. We extracted the treatment effective data and radiation related toxicities data. The clinical efficacy and radiation toxicity was pooled by meta-analysis. The statistical heterogeneity was evaluated by I 2 tests.


RESULTS
By searching the related databases, we finally included 7 studies in this meta-analysis. The pooled results indicated that Shenqi Fuzheng injection can improve the clinical efficacy (relative risk [RR] =1.27, 95% confidence interval [CI]: 1.13-1.43), and decrease the radiation pneumonia (RR = 0.41, 95% CI: 0.26-0.46), radiation esophagitis (RR = 0.46, 95% CI: 0.37-0.59) and bone marrow suppression (RR = 0.44, 95% CI: 0.36-0.53).


CONCLUSIONS
Shenqi Fuzheng injection can improve the clinical efficacy and decrease the radiation toxicities in the NSCLC patients treated with radiation.
Huijuan
H
Jiang
Department of Radiotherapy, Huaihe Hospital of Henan University, Henan, Kaifeng 475000, China.
Hongzhi
H
Zhang
Xigang
X
Hu
Jing
J
Ma
D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D016017:Odds Ratio; D017594:Publication Bias; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; C521737:shenqi fuzheng