S. aureus Toxins Join the DARC Side.
Staphylococcus aureus, like other bacterial pathogens, scavenges host iron for growth through incompletely understood mechanisms. In this issue of Cell Host & Microbe, Spaan et al. (2015) demonstrate that two Staphylococcus aureus leukotoxins, HlgAB and LukED, target the Duffy antigen receptor for chemokines on erythrocytes, resulting in lysis and iron release.
Department of Pediatrics, Columbia University, 650 West 168(th) Street, New York, NY 10032, USA. Electronic address: ar127@columbia.edu.
Adam J
AJ
Ratner
D004375:Duffy Blood-Group System / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis; D054884:Host-Pathogen Interactions; D006801:Humans; D007956:Leukocidins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000378:metabolism*
D004375:Duffy Blood-Group System; D007956:Leukocidins; D011956:Receptors, Cell Surface