Marinopyrroles: Unique Drug Discoveries Based on Marine Natural Products.
Natural products provide a successful supply of new chemical entities (NCEs) for drug discovery to treat human diseases. Approximately half of the NCEs are based on natural products and their derivatives. Notably, marine natural products, a largely untapped resource, have contributed to drug discovery and development with eight drugs or cosmeceuticals approved by the U.S. Food and Drug Administration and European Medicines Agency, and ten candidates undergoing clinical trials. Collaborative efforts from drug developers, biologists, organic, medicinal, and natural product chemists have elevated drug discoveries to new levels. These efforts are expected to continue to improve the efficiency of natural product-based drugs. Marinopyrroles are examined here as a case study for potential anticancer and antibiotic agents.
Department of Pharmaceutical Sciences, Center for Drug Discovery, College of Pharmacy, Cancer Genes and Molecular Regulation Program, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-6805.
Rongshi
R
Li
D000900:Anti-Bacterial Agents / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry; D059001:Aquatic Organisms; D001419:Bacteria / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D003358:Cosmetics; D015195:Drug Design; D055808:Drug Discovery; D005060:Europe; D006801:Humans; D008386:Marine Biology; D055624:Methicillin-Resistant Staphylococcus aureus; D009369:Neoplasms / Q000188:drug therapy; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D012623:Seawater; D014481:United States; D014486:United States Food and Drug Administration
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D003358:Cosmetics; D004364:Pharmaceutical Preparations; D011758:Pyrroles
Staphylococcus aureus; antibiotics; anticancer; drug discovery; marine natural products; marinopyrroles