C282Y and H63D Polymorphisms in Hemochromatosis Gene and Risk of Parkinson's Disease: A Meta-Analysis.
OBJECTIVE
A meta-analysis was performed to better clarify the association between hemochromatosis (HFE) gene and the risk of Parkinson's disease (PD).


METHODS
Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated from fixed- and random-effect models. Heterogeneity among studies was evaluated using the I(2) and Q test. Egger's test was used to estimate the publication bias.


RESULTS
We identified 8 articles with 9 independent studies for this meta-analysis. The present meta-analysis showed no significant association of Y allele with the risk of PD in dominant (OR = 0.87, 95% CI = 0.70-1.09), recessive (OR = 1.58, 95% CI = 0.61-4.10), and codominant (OR = 0.88, 95% CI = 0.72-1.09) models for C282Y. There were also no significant associations of D allele with the risk of PD in dominant (OR = 1.04, 95% CI = 0.87-1.24), recessive (OR = 1.23, 95% CI = 0.70-2.18), and codominant (OR = 1.04, 95% CI = 0.89-1.22) genetic models for H63D. No publication bias was detected.


CONCLUSIONS
The meta-analysis indicated that C282Y and H63D polymorphisms in the HFE gene might not be associated with PD.
Ji'nan Children's Hospital, Ji'nan, Shandong, China.
Chunhong
C
Duan
Ji'nan Children's Hospital, Ji'nan, Shandong, China.
Meiyun
M
Wang
Ji'nan Center For Disease Control And Prevention, Ji'nan, Shandong, China.
Yan
Y
Zhang
Ji'nan Children's Hospital, Ji'nan, Shandong, China.
Xuxia
X
Wei
Ji'nan Children's Hospital, Ji'nan, Shandong, China.
Yan
Y
Huang
Ji'nan Children's Hospital, Ji'nan, Shandong, China.
Hongxia
H
Zhang
Ji'nan Children's Hospital, Ji'nan, Shandong, China.
Lu
L
Cheng
Ji'nan Children's Hospital, Ji'nan, Shandong, China gaizhongtaojn@163.com.
Zhongtao
Z
Gai
D000071020:Hemochromatosis Protein / Q000235:genetics*; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics*
C103673:HFE protein, human; D000071020:Hemochromatosis Protein
Parkinson’s disease; gene; hemochromatosis; meta-analysis