Primary thymic extranodal marginal zone B cell lymphoma as an incidental finding in a Caucasian woman.
Primary thymic extranodal marginal zone B cell lymphoma (TML) is an extremely rare lymphoma strongly associated with autoimmune disease. We report an exceedingly rare case of TML found in a non-Asian population. TML was found incidentally in a 60-year-old Caucasian woman with a short history of muscle and joint pain. An anterior mediastinal mass was detected by a positron emission tomography-CT (PET-CT) scan and thymectomy was performed. The mass was contained within the thymus with a homogeneous pale cut surface with solid areas. Histologically, the typical morphological and immunophenotypic features of TML were found, with a prominent lymphoid infiltrate comprising of small-to-medium-sized neoplastic lymphocytes, plasmacytic differentiation and a distorted thymic epithelial network. Postoperative follow-up has indicated an associated undifferentiated connective tissue disease (UCTD) with features of systemic lupus erythaematosus.
Department of Pathology, Odense University Hospital, Odense, Fyn, Denmark.
Jeanette Krogh
JK
Petersen
Department of Hematology, Odense University Hospital, Odense, Fyn, Denmark.
Thomas Stauffer
TS
Larsen
Department of Pathology, Odense University Hospital, Odense, Fyn, Denmark.
Michael Boe
MB
Møller
Department of Pathology, Odense University Hospital, Odense, Fyn, Denmark.
Claudia
C
Stahlberg
D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008180:Lupus Erythematosus, Systemic / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D013953:Thymus Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed