Micronucleus testing as a cancer detector: endometrial hyperplasia to carcinoma.
OBJECTIVE
Endometrium carcinoma (EC) is the fourth common cancer among women worldwide and the incidence is increasing. It is important to define the EC earlier for survival of the patients.


METHODS
Women who had endometrial hyperplasia (EH) and EC in postmenopausal and premenopausal period were included to participate in this study. MN assay has been performed to participants for detection of the genetic damages and DNA instability.


RESULTS
MN ratio was significantly higher in EC group compared to other two groups (EH and control groups) (p < 0.001). On the other hand, there was no significant difference among these groups with regard to number of gravidity and presence of a family history of cancer (p > 0.05). MN frequency and NDI were significantly correlated with the age in endometrial hyperplasia without atypia, endometrial cancer and control groups (r 0.546, p < 0.001; r 0.320, p 0.024; r 0.396, p 0.003, respectively). Similarly, MN frequency and NDI were significantly correlated with BMI in three groups (r 0.287, p 0.044; r 0.467, p 0.001; r 0.473, p 0.001, respectively).


CONCLUSIONS
MN scoring in pre-neoplastic conditions of the endometrium can be used as adjunct in endometrium cancer screening. By using MN assay, discrimination may be possible among endometrial cancer, endometrial precancerous lesions and pathologically normal patients. This is an easy, simple, reliable, reproducible objective test and can be used in routine patient examination.
Department of Medical Genetics, Education and Research Hospital, 38210, Kayseri, Turkey. aslihankiraz@gmail.com.
Aslihan
A
Kiraz
Department of Gynecology, Education and Research Hospital, Kayseri, Turkey.
Gokhan
G
Açmaz
Department of Gynecology, Education and Research Hospital, Kayseri, Turkey.
Gulsum
G
Uysal
Department of Radiation Oncology, Education and Research Hospital, Kayseri, Turkey.
Dilek
D
Unal
Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Hamiyet
H
Dönmez-Altuntas
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D004714:Endometrial Hyperplasia / Q000235:genetics* / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology*; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D015162:Micronucleus Tests / Q000379:methods*; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D014421:Turkey
DNA instability; Endometrial carcinoma; Endometrial hyperplasia; Micronucleus; Precancerous lesions