[Which dose constraints on which critical organs in paediatric radiation therapy?].
Cancers in childhood are rare, representing 1% of all the cancers in developing countries. On the whole, the overall survival approaches 75% at 5 years. The radiation dose decrease in lots of indications as well as better optimized planning treatments lead to decrease the long-term toxicities in some indications. However, the radiation toxicity remains frequent, often specific of pediatric situations. Long-term toxicities are mainly neurologic, sensitive, endocrine, or linked to growth impairment (bones or muscular). Radio-induced second-cancers are also frequent after a long follow-up after cancer in childhood but will not be discussed here. Doses to critical organs as well as the most frequent radio-induced late-effects will be discussed in this paper.
Département de radiothérapie, centre Léon-Bérard, 28, rue Laennec, 69008 Lyon, France. Electronic address: line.claude@lyon.unicancer.fr.
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Claude
Département de radiothérapie, institut Claudius-Regaud à l'institut universitaire du cancer Toulouse-Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse, France; Université Toulouse-III-Paul-Sabatier, place du Dr-Joseph-Baylac, 31024 Toulouse cedex 3, France; Inserm U825, place du Dr-Joseph-Baylac, 31024 Toulouse cedex 3, France.
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Laprie
D002648:Child; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D009929:Organ Size; D058958:Organs at Risk; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage / Q000592:standards*
Cancer; Critical organs; Organes critiques; Pediatric cancer; Pédiatrie; Toxicity; Toxicité