Factors affecting survival of medulloblastoma in children: the changing concept of management.
Medulloblastoma (MB) is a type of malignant tumor arising only in the cerebellum that was first defined by Cushing and Bailey in 1920s. In this review paper, we trace the evolution of risk stratification and the correlated changing concept of management in the past years. Outcome analysis of the hospital series of the Taipei Veterans General Hospital, Cheng Hsin General Hospital, and Taipei Medical University Hospital was performed to correlate prognostic indicators with reported studies. The purpose is to provide clues for age-specific and risk-adjusted optimal, effective, but beneficial and protective treatment strategies of these tumors in children.
Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. ttwong99@tmu.edu.tw.|Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan. ttwong99@tmu.edu.tw.|Pediatric Neurosurgery, Department of Neurosurgery, Taipei Medical University Hospital, 252 Wuxing St, Taipei, 11031, Taiwan. ttwong99@tmu.edu.tw.
Tai-Tong
TT
Wong
Department of Pediatrics, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.|National Taiwan University and Academia Sinica, Taipei, Taiwan.
Yen-Lin
YL
Liu
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
Donald Ming-Tak
DM
Ho
Department of Pediatrics, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
Kai-Ping
KP
Chang
Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
Muh-Lii
ML
Liang
Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
Hsin-Hung
HH
Chen
Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
Yi-Yen
YY
Lee
Department of Radiology, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
Feng-Chi
FC
Chang
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
Shih-Chieh
SC
Lin
Department of Pediatrics, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
Ting-Rong
TR
Hsu
Department of Internal Medicine, Cheng Hsin General Hospital, Taipei, Taiwan.
Kuo-Wei
KW
Chen
Department of Pathology, Cheng Hsin General Hospital, Taipei, Taiwan.
Wei-Kang
WK
Kwang
Department of Radiology, Chen Hsin General Hospital, Taipei, Taiwan.
Wu-Yu
WY
Hou
Department of Radiation Oncology, Cheng Hsin General Hospital, Taipei, Taiwan.
Chung-Yih
CY
Wang
Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
Sang-Hue
SH
Yen
Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
Wan-You
WY
Guo
Department of Oncology, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, 201 Sec 2 Shi Pai Rd, Taipei, 11217, Taiwan. chenyw@vghtpe.gov.tw.
Yi-Wei
YW
Chen
D000293:Adolescent; D000367:Age Factors; D002528:Cerebellar Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D019468:Disease Management; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology; D016896:Treatment Outcome