Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole.
Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI.
Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR.
Akbar
A
Anaeigoudari
Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR.
Mohammad Naser
MN
Shafei
Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR.
Mohammad
M
Soukhtanloo
Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR.
Hamid Reza
HR
Sadeghnia
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IQ.
Parham
P
Reisi
Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR.
Farimah
F
Beheshti
Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR.
Reza
R
Mohebbati
Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR.
Seyed Mojtaba
SM
Mousavi
Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR.
Mahmoud
M
Hosseini
D000818:Animals; D001923:Brain Chemistry; D007191:Indazoles / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D007191:Indazoles; D008070:Lipopolysaccharides; D018696:Neuroprotective Agents; C080122:7-nitroindazole