Typhoid Fever Complicated by Hemophagocytic Lymphohistiocytosis and Rhabdomyolysis.
Hemophagocytic lymphohistiocytosis (HLH) and rhabdomyolysis are rare complications of typhoid fever from Salmonella enterica serovar Typhi. Herein, we describe the clinical features in a 21-year-old female from India who presented to the intensive care unit with fever, severe pancytopenia, and rhabdomyolysis.
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Division of Pulmonary and Critical Care, Washington University School of Medicine, St. Louis, Missouri lnon@dom.wustl.edu.
Lemuel R
LR
Non
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Division of Pulmonary and Critical Care, Washington University School of Medicine, St. Louis, Missouri.
Rupa
R
Patel
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Division of Pulmonary and Critical Care, Washington University School of Medicine, St. Louis, Missouri.
Amir
A
Esmaeeli
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Division of Pulmonary and Critical Care, Washington University School of Medicine, St. Louis, Missouri.
Vladimir
V
Despotovic
D052978:Disk Diffusion Antimicrobial Tests; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever; D006801:Humans; D007194:India; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000188:drug therapy; D012206:Rhabdomyolysis / Q000150:complications* / Q000188:drug therapy; D012485:Salmonella typhi / Q000187:drug effects / Q000302:isolation & purification*; D018805:Sepsis; D013419:Sulfamethizole / Q000627:therapeutic use; D016896:Treatment Outcome; D014295:Trimethoprim / Q000627:therapeutic use; D014435:Typhoid Fever / Q000150:complications* / Q000188:drug therapy; D055815:Young Adult; D000096926:Benzenesulfonamides
D004338:Drug Combinations; D013419:Sulfamethizole; D014295:Trimethoprim; C029078:trimethoprim sulfamethizole; D000096926:Benzenesulfonamides