Angiostrongylus vasorum Causing Severe Granulomatous Hepatitis with Concurrent Multiple Acquired PSS.
A 14 mo old female Jack Russell terrier presented with a 12 hr history of vomiting and inappetence. She was subsequently diagnosed with multiple acquired portosystemic shunts during an exploratory celiotomy. Gross and histopathological hepatic abnormalities were consistent with chronic disease, including features suggestive of portal hypertension that was potentially caused by migrating and resident Angiostrongylus vasorum larvae. Fecal analysis and polymerase chain reaction of hepatic tissue confirmed the presence of Angiostrongylus vasorum . The dog recovered clinically following empirical treatment and supportive care. A lack of parasite burden was confirmed 9 wk postdiagnosis; however, serum biochemical analysis at that time was suggestive of ongoing hepatic dysfunction.
From the Department of Clinical Sciences and Services (S.C., R.M.) and Department of Pathology and Pathogen Biology (S.P., D.B.), The Royal Veterinary College, University of London, Hatfield, United Kingdom (S.C.).
Simon
S
Cook
From the Department of Clinical Sciences and Services (S.C., R.M.) and Department of Pathology and Pathogen Biology (S.P., D.B.), The Royal Veterinary College, University of London, Hatfield, United Kingdom (S.C.).
Simon L
SL
Priestnall
From the Department of Clinical Sciences and Services (S.C., R.M.) and Department of Pathology and Pathogen Biology (S.P., D.B.), The Royal Veterinary College, University of London, Hatfield, United Kingdom (S.C.).
Damer
D
Blake
From the Department of Clinical Sciences and Services (S.C., R.M.) and Department of Pathology and Pathogen Biology (S.P., D.B.), The Royal Veterinary College, University of London, Hatfield, United Kingdom (S.C.).
Richard L
RL
Meeson
D000801:Angiostrongylus / Q000302:isolation & purification*; D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000469:parasitology* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D005260:Female; D005273:Fenbendazole / Q000627:therapeutic use; D006099:Granuloma / Q000469:parasitology / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D006520:Hepatitis, Animal / Q000469:parasitology* / Q000473:pathology / Q000628:therapy; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D018942:Macrolides / Q000627:therapeutic use; D017206:Strongylida Infections / Q000150:complications / Q000473:pathology / Q000628:therapy / Q000662:veterinary*
D000969:Antinematodal Agents; D018942:Macrolides; D005273:Fenbendazole; C027837:moxidectin