Application of monodirectional Janus patch to oromucosal delivery system.
Drug delivery through mucosae has received huge research attention owing to its advantageous characteristics such as accurate dose control and the avoidance of premature metabolism of vulnerable drugs by oral administration. However, body fluid in mucosae may dissolve the drug, releasing it to unwanted directions. Here, a Janus drug delivery patch with monodirectional diffusion property is devised to deliver drugs efficiently and to overcome the issue of unwanted drug release. A polyester fabric is coated with a hydrophobic polymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluorodecyl methacrylate), via initiated chemical vapor deposition. Subsequently, hydrophilicity is rendered selectively on one surface by base-catalyzed hydrolysis to obtain a Janus substrate with both hydrophobic and hydrophilic surfaces. The hydrophilic surface of the Janus substrate is further coated with resveratrol-loaded hydrogel to produce a Janus drug delivery patch. The fabricated patch efficiently blocks fluid penetration from one side to the other in mucous environment. Delivery of resveratrol through hairless mouse skin and reconstructed human mucosae using Janus patch shows higher permeation flux compared to bare control patch. The Janus drug delivery patch shown in this study can be a useful tool for efficient transmucosal delivery of various kinds of drugs.
Department of Chemical and Biomolecular Engineering and Graphene Research Center (GRC), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea.
Jae Bem
JB
You
College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, Republic of Korea.
Ah Young
AY
Choi
Department of Chemical and Biomolecular Engineering and Graphene Research Center (GRC), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea.
Jieung
J
Baek
Department of Chemical and Biomolecular Engineering and Graphene Research Center (GRC), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea.
Myung Seok
MS
Oh
Department of Chemical and Biomolecular Engineering and Graphene Research Center (GRC), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea.
Sung Gap
SG
Im
College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, Republic of Korea.|College of Pharmacy, Chungbuk National University, Cheongju, 362-763, Republic of Korea.
Kyung Eun
KE
Lee
College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, Republic of Korea.|College of Pharmacy, Chungbuk National University, Cheongju, 362-763, Republic of Korea.
Hye Sun
HS
Gwak
D000284:Administration, Oral; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D051379:Mice; D009061:Mouth Mucosa / Q000187:drug effects / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000493:pharmacokinetics; D057968:Transdermal Patch
D020100:Hydrogels; D011108:Polymers; D013267:Stilbenes; D000077185:Resveratrol
Janus patch; drug delivery; initiated chemical vapor deposition (iCVD); monodirectional; oromucosa