Possible intermediary role of ghrelin in seborrhea.
Seborrhea, or oily skin, is a very common condition, especially among young people, caused by the increased secretion of sebum by sebaceous glands in the skin. Based on today's knowledge, a regulatory role of various hormones especially androgens is considered for sebaceous gland secretion; but despite significant evidences emphasis on the effects of the gastrointestinal disorders on coetaneous manifestations, the role of gastrointestinal problems in sebum secretion has not been emphasized yet. This study aimed to explain hormonal changes occurring in gastroesophageal reflux disease which may cause changes in sebaceous gland secretion so that, by explaining these communication mechanisms, common investigations between gastroenterology and dermatology can be performed to evaluate the accuracy of this hypothesis.
School of Iranian Traditional Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Yazd, Iran.
Zareie
Z
Elham
Colorectal Research Center, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Agah
A
Shahram
Herbal Medicine Department, Research Institute for Islamic & Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: sadeghpouromid@yahoo.com.
Sadeghpour
S
Omid
D000728:Androgens / Q000378:metabolism; D012628:Dermatitis, Seborrheic / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000378:metabolism; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008055:Lipids / Q000737:chemistry; D012627:Sebaceous Glands / Q000378:metabolism; D012629:Sebum / Q000378:metabolism; D012867:Skin / Q000378:metabolism
D000728:Androgens; D054439:Ghrelin; D008055:Lipids