Nanoparticle approaches to combating drug resistance.
Multidrug resistance (MDR) among cancer cells is a serious impediment to the success of conventional chemotherapy. The emergence of nanomedicine demonstrates great promise in overcoming MDR through multiple mechanisms. Nanoparticles have been shown to overcome the MDR at the tissue level through increased intratumoral accumulation resulting from enhanced permeation and retention, neovascular cell targeting, and externally triggered local drug release. Nanoparticles have also demonstrated the ability to overcome the MDR at the cellular/subcellular level by enhancing intracellular drug accumulation, improving drug-target accessibility, or even interfering with existing MDR mechanisms.
Department of Chemical & Biomolecular Engineering, & Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Jae Hyon
JH
Moon
Department of Chemical & Biomolecular Engineering, & Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
James W
JW
Moxley
Department of Chemical & Biomolecular Engineering, & Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Pengcheng
P
Zhang
Department of Chemical & Biomolecular Engineering, & Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.|Department of Oncology & Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
Honggang
H
Cui
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D000970:Antineoplastic Agents; D004337:Drug Carriers