Addition of Histology to the Paris Classification of Pediatric Crohn Disease Alters Classification of Disease Location.
OBJECTIVE
The aim of the study was to investigate the value of microscopic findings in the classification of pediatric Crohn disease (CD) by determining whether classification of disease changes significantly with inclusion of histologic findings.


METHODS
Sixty patients were randomly selected from a cohort of patients studied at the Pediatric Inflammatory Bowel Disease Clinic at the University of California, San Francisco Benioff Children's Hospital. Two physicians independently reviewed the electronic health records of the included patients to determine the Paris classification for each patient by adhering to present guidelines and then by including microscopic findings.


RESULTS
Macroscopic and combined disease location classifications were discordant in 34 (56.6%), with no statistically significant differences between groups. Interobserver agreement was higher in the combined classification (κ = 0.73, 95% confidence interval 0.65-0.82) as opposed to when classification was limited to macroscopic findings (κ = 0.53, 95% confidence interval 0.40-0.58). When evaluating the proximal upper gastrointestinal tract (Paris L4a), the interobserver agreement was better in macroscopic compared with the combined classification.


CONCLUSIONS
Disease extent classifications differed significantly when comparing isolated macroscopic findings (Paris classification) with the combined scheme that included microscopy. Further studies are needed to determine which scheme provides more accurate representation of disease extent.
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco.
Melissa A
MA
Fernandes
Sofia G
SG
Verstraete
Elizabeth A
EA
Garnett
Melvin B
MB
Heyman
D002140:California; D002648:Child; D003424:Crohn Disease / Q000145:classification* / Q000473:pathology; D005260:Female; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008853:Microscopy / Q000379:methods; D010297:Paris; D010641:Phenotype; D041742:Upper Gastrointestinal Tract / Q000473:pathology*