Periodontal treatment and HbA1c levels in subjects with diabetes mellitus.
It has earlier been reported that individuals with poorly controlled diabetes have severe periodontal disease (PD) compared to well-controlled diabetes. This longitudinal interventional study compared periodontal treatment outcomes with HbA1c level changes in four groups of diabetic and non-diabetic patients with or without PD, respectively. HbA1c, bleeding on probing (BOP), plaque index and periodontal pocket depth (PPD) 4 < 6 mm and ≥6 mm were recorded at baseline to 3 months after non-surgical treatment and 3-6 months for surgical treatment in subjects with or without T2D, and with or without PD. A total of 129 patients were followed from baseline to 6 months. Diabetics with PD and without PD showed reductions in HbA1c levels with a mean value of 0·3% after 3 months and mean values of 1% and 0·8%, respectively, after 6 months. Diabetics with PD showed higher levels of BOP versus non-diabetics without PD (P < 0·01) and versus diabetics without PD (P < 0·05) at baseline. After 6 months, diabetics with PD showed higher number of PPD 4 < 6 mm versus diabetics without PD (P < 0·01) and non-diabetics with PD (P < 0·01). Diabetics without PD showed higher levels of PPD 4 < 6 mm versus non-diabetics without PD (P < 0·01). Surgical and non-surgical periodontal treatment in all groups improved periodontal inflammatory conditions with a decrease in HbA1c levels in a period of three and 6 months. No change was seen in the number of pockets PPD 4 < 6 mm in diabetic subjects with PD after non-surgical and surgical treatment.
Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.|Division of Periodontology, Department of Dental Medicine, Altamash Institute of Dental Medicine, Karachi, Pakistan.
M
M
Altamash
Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.|Department of Periodontology, Faculty of Odontology, Malmo University, Malmo, Sweden.
B
B
Klinge
Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
P-E
PE
Engström
D055113:Chronic Periodontitis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D017622:Periodontal Attachment Loss / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000378:metabolism / Q000503:physiopathology*; D012648:Self Care; D016896:Treatment Outcome
D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
HbA1c; dental plaque indexes; gingival bleeding on probing; periodontal disease; type 2 diabetes mellitus