Investigating the effect of TiO2on the structure and biocompatibility of bioactive glass.
Titanium (Ti4+) containing materials have been widely used in medical applications due to its associated bioactivity in vivo. This study investigates the replacement of Si4+with Ti4+within the system SiO2-Na2O-CaO-P2O5to determine its influence on glass structure. This strategy was conducted in order to control the glass solubility to further improve the cellular response. Ti4+incorporation was found to have little influence on the glass transition temperature (Tg= 520 ± 8°C) and magic angle spinning-nuclear magnetic resonance (MAS-NMR) shifts (-80 ppm) up to additions of 18 wt %. However, at 30 wt % the Tgincreased to 600°C and MAS-NMR spectra shifted to -88 ppm. There was also an associated reduction in glass solubility as a function of Ti4+incorporation as determined by inductively coupled plasma optical emission spectroscopy where Si4+(1649-44 mg/L) and Na+(892-36 mg/L) levels greatly reduced while Ca2+(3-5 mg/L) and PO43- (2-7 mg/L) levels remained relatively unchanged. MC3T3 osteoblasts were used for cell culture testing and it was determined that the Ti4+glasses increased cell viability and also facilitated greater osteoblast adhesion and proliferation to the glass surface compared to the control glass. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1703-1712, 2016.
Inamori School of Engineering, Alfred University, Alfred, New York.
Lana M
LM
Placek
Inamori School of Engineering, Alfred University, Alfred, New York.
Timothy J
TJ
Keenan
Inamori School of Engineering, Alfred University, Alfred, New York.
Yiming
Y
Li
Inamori School of Engineering, Alfred University, Alfred, New York.
Chokchai
C
Yatongchai
Inamori School of Engineering, Alfred University, Alfred, New York.
Dimple
D
Pradhan
Department of Applied Oral Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
Daniel
D
Boyd
Inamori School of Engineering, Alfred University, Alfred, New York.
Nathan P
NP
Mellott
Inamori School of Engineering, Alfred University, Alfred, New York. wren@alfred.edu.
Anthony W
AW
Wren
D000818:Animals; D002460:Cell Line; D002516:Ceramics / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D014025:Titanium / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
C022107:Bioglass; C009495:titanium dioxide; D014025:Titanium
bioactive glass; cell culture; ion release; solubility; titanium