Efficiency of selenium in attenuating epididymal histopathological changes in hypercholesterolaemic adult rat.
BACKGROUND
Studies on sperm maturation, epididymal histology, or epididymal tubule physiology are significant parts in reproductive researches. The present study was aimed to evaluate the effect of induced hypercholesterolaemia on the epididymis of adult albino rats and to clarify the possible protective role of selenium.


METHODS
Forty adult albino Wistar rats were divided into four groups; untreated control group (group I), sham control (group II), group with induced hypercholesterolaemia (group III), group with induced hypercholesterolaemia treated with selenium 0.25 mg/kg/day (group IV).


RESULTS
Histological and ultrastructural examination of the epididymal epithelial cells of hypercholesterolaemic rats (group III) showed loss of cilia with many vacuolations, fatty degenerative changes and increased collagen fibres. Morphometrically significant increase (p < 0.0001) in the per cent area of collagen fibres with no significant change in the optical density of periodic acid Schiff reaction (p > 0.05). Selenium treated group (group IV) produced marked improvement in histological, ultrastructural and morphometric results as compared with group III.


CONCLUSIONS
It could be concluded that hypercholesterolaemia produced deleterious effects to the epididymis and selenium could attenuate these effects.
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Abdel Gawad
Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, Egypt. ehab.elshaarawy@yahoo.com.
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El-Shaarawy
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Rizk
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Sayed
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Emam
epididymis; histopathology; hypercholesterolaemia; selenium