Combination therapy with nifedipine GITS 60 mg: subanalysis of a prospective, 12-week observational study (AdADOSE).
BACKGROUND
AdADOSE was a 12-week, international, observational study conducted in the Middle East and Russia where patients received nifedipine gastrointestinal therapeutic system (GITS) at a daily dose of 30, 60, or 90 mg as part of an antihypertensive combination therapy. This subgroup analysis of the AdADOSE study assesses the efficacy and tolerability of nifedipine GITS combination therapy when used specifically at the 60-mg strength.


METHODS
Patients with hypertension who received a daily nifedipine GITS dose of 60 mg, either at constant dose (n = 686) or up-titrated from 30 mg (n = 392), were analyzed. Target blood pressure (BP) was <140/90 mmHg (or <130/80 mmHg for those at high/very high cardiovascular risk).


RESULTS
Following nifedipine GITS combination therapy, target BP was achieved by 33.7% patients in the 60 mg group (previously untreated, 42.5%; previously treated, 32.0%) and 32.4% patients in the 30-60 mg group (previously untreated, 45.2%; previously treated, 30.7%). Mean systolic BP/diastolic BP changes were -40.3/-20.7 mmHg and -35.6/-18.5 mmHg, respectively, and were similar regardless of previous antihypertensive treatment or the number of concomitant diseases. Incidences of drug-related adverse events (AEs) were low (3.2%, 60 mg; 2.0%, 30-60 mg group), few patients discontinued because of AEs (0.6% and 1.0%, respectively), and there were no serious AEs.


CONCLUSIONS
Combination therapy with nifedipine GITS 60 mg in a real-life observational setting was effective and well tolerated in hypertensive patients, with low rates of treatment-related AEs.
a Cardiovascular Medicine Department, Faculty of Medicine, Azhar University , Giza , Egypt .
Ahmed K
AK
Motaweih
b Outpatient Department , Clinical Hospital 122 , Saint Petersburg , Russia .
Elena
E
Usova
c Department of Cardiology , Baqai Institute of Cardiovascular Diseases , Karachi , Pakistan .
Wajid
W
Hussain
d Department of Cardiology , Dallah Hospital , Riyadh , Saudi Arabia , and.
Ziad
Z
Dello
e Global Medical Affairs Primary Care, Bayer Pharma AG , Berlin , Germany.
Thomas
T
Petri
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D004359:Drug Therapy, Combination / Q000379:methods; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D008877:Middle East; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies; D012426:Russia; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D009543:Nifedipine
AdADOSE; cardiovascular; hypertension; nifedipine GITS; observational study