IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease.
We conducted this case-control study to investigate the genetic role of IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T in the development of coronary artery disease (CAD) in a Chinese population. Polymorphisms IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T were determined by polymerase chain reaction restriction fragment length polymorphism assay. The CAD patients were more likely to be cigarette smokers, have a history of hypertension, have a higher value of total cholesterol, triglycerides, and low-density lipoprotein cholesterol, and have a lower value of high-density lipoprotein cholesterol. Conditional logistic regression analyses showed that the CC genotype of IL-6-174G/C was significantly associated with increased risk of CAD [odds ratio (OR) = 2.99, 95% confidence interval (95%CI) = 1.56-6.00]. Moreover, the GG genotype of IL-6-572C/G was correlated with increased risk of CAD (OR = 1.99, 95%CI = 1.25-3.19). We found that IL-6-174G/C and IL-6-572C/G gene polymorphisms are associated with an increased risk of CAD.
Department of Cardiovascular Internal Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou.
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Li
Department of Cardiovascular Internal Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou.
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Li
Department of Cardiovascular Internal Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou.
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LH
Zhang
Department of Cardiovascular Internal Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou.
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LG
Jian
Department of Ultrasonic Medicine, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou, Henan, China.
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HP
Liu
Department of Gerontology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
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T
Wang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000378:metabolism; D003324:Coronary Artery Disease / Q000235:genetics* / Q000378:metabolism; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics*; D007378:Interleukins / Q000235:genetics; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D008076:Cholesterol, HDL; C508609:IL10 protein, human; C508585:IL1B protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D007378:Interleukins; D008077:Lipoproteins, LDL; D016753:Interleukin-10