Proteomics in Rheumatoid Arthritis Research.
Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in the clinical field to assess disease activity and severity. Recently, there has been increasing interest in the discovery of new diagnostic RA biomarkers that can assist in evaluating disease activity, severity, and treatment response. Proteomics, the large-scale study of the proteome, has emerged as a powerful technique for protein identification and characterization. For the past 10 years, proteomic techniques have been applied to different biological samples (synovial tissue/fluid, blood, and urine) from RA patients and experimental animal models. In this review, we summarize the current state of the application of proteomics in RA and its importance in identifying biomarkers and treatment targets.
Division of Rheumatology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea. ; POSTECH-CATHOLIC Biomedical Engineering Institute, The Catholic University of Korea, Seoul 06591, Korea.
Yune-Jung
YJ
Park
Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Min Kyung
MK
Chung
Department of New Biology and Center for Plant Aging Research, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu 43014, Korea.
Daehee
D
Hwang
POSTECH-CATHOLIC Biomedical Engineering Institute, The Catholic University of Korea, Seoul 06591, Korea. ; Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Wan-Uk
WU
Kim
Biomarker; Proteomics; Rheumatoid arthritis