High Risk of Herpes Zoster among Patients with Advance Acute Kidney Injury--A Population-Based Study.
The risk for herpes zoster (HZ) in acute kidney injury (AKI) survivors was never explored. We identified 2,387 adults in the Taiwan National Health Insurance Research Database who recovered from dialysis-requiring AKI and matched them with non-recovery and non-AKI patients by propensity score. During a mean follow-up of 2.7 years, the incidences of HZ were 6.9, 8.2 and 4.8 episodes per 1,000 person-years in AKI-non-recovery, AKI-recovery and non-AKI group, respectively. The recovery group was more likely to develop herpes zoster than those without acute kidney injury [incidence-rate ratios 1.71, 95% confidence interval 1.16-2.52; p = 0.007]. Patients without acute kidney injury were less likely to develop herpes zoster than those AKI, recovered from dialysis or not (hazard ratio HR 0.66, 95% CI 0.46-0.95). Dialysis-requiring acute kidney injury poses a long-term risk of herpes zoster after hospital discharge. Even patients who have recovered from dialysis still carry a significantly higher risk of developing herpes zoster.
Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu city, Taiwan.|College of Medicine, National Taiwan University, Taipei, Taiwan.
Wei-Shun
WS
Yang
International-Harvard Statistical Consulting Company, Taipei, Taiwan.
Fu-Chang
FC
Hu
Department of Family Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.
Meng-Kan
MK
Chen
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Wen-Je
WJ
Ko
Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Likwang
L
Chen
College of Medicine, National Taiwan University, Taipei, Taiwan.|Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Kwan-Dun
KD
Wu
College of Medicine, National Taiwan University, Taipei, Taiwan.|Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Vin-Cent
VC
Wu
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000453:epidemiology*; D017677:Age Distribution; D015984:Causality; D015897:Comorbidity; D018572:Disease-Free Survival; D005260:Female; D006562:Herpes Zoster / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011157:Population Dynamics; D015995:Prevalence; D006435:Renal Dialysis / Q000706:statistics & numerical data*; D018570:Risk Assessment; D017678:Sex Distribution; D017741:Survivors / Q000706:statistics & numerical data; D013624:Taiwan / Q000453:epidemiology