Psychopharmacology and Bariatric Surgery.
Currently, it has been demonstrated that psychotropic drugs, particularly antidepressants, are frequently prescribed for patients who seek bariatric surgery. Many bariatric surgery patients have a history of a mood disorder. Unlike medications for diabetes, hypertension or hyperlipidemia, which are generally reduced and at times discontinued, postsurgery antidepressants use is only slightly reduced. The Roux-en-Y procedure is most frequently associated with alteration in drug exposure. Medication disintegration, dissolution, absorption, metabolism and excretion have been found to be altered in postbariatric patients, although data are sparse at this time. This paper will review the current evidence regarding the effect of bariatric surgery on drug treatment including mechanism of interference as well as the extent of changes identified to date. Data will be presented as controlled trials followed by case series and reports.
Department of Psychiatry and Behavioral Science, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.|Neuropsychiatric Research Institute, Fargo, ND, USA.
James L
JL
Roerig
Neuropsychiatric Research Institute, Fargo, ND, USA.|Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Grand Forks, ND, USA.
Kristine
K
Steffen
D000928:Antidepressive Agents / Q000627:therapeutic use; D050110:Bariatric Surgery / Q000523:psychology*; D018849:Controlled Clinical Trials as Topic; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy; D009765:Obesity / Q000523:psychology / Q000601:surgery*; D011600:Psychopharmacology; D011619:Psychotropic Drugs / Q000627:therapeutic use*
D000928:Antidepressive Agents; D011619:Psychotropic Drugs
experimental; obesity; pharmacotherapy; physiology; treatment