Analysis of difference of association between polymorphisms in the XRCC5, RPA3 and RTEL1 genes and glioma, astrocytoma and glioblastoma.
BACKGROUND
Gliomas are the most common aggressive brain tumors and have many complex pathological types. Previous reports have discovered that genetic mutations are associated with the risk of glioma. However, it is unclear whether uniform genetic mutations exist difference between glioma and its two pathological types in the Han Chinese population.


METHODS
We evaluated 20 SNPs of 703 glioma cases (338 astrocytoma cases, 122 glioblastoma cases) and 635 controls in a Han Chinese population using χ(2) test and genetic model analysis.


RESULTS
In three case-control studies, we found rs9288516 in XRCC5 gene showed a decreased risk of glioma (OR, 0.85; 95% CI, 0.73-0.99; P = 0.042) and glioblastoma (OR, 0.70; 95% CI, 0.52-0.92; P = 0.001) in the allele model. We identified rs414805 in RPA3 gene showed an increased risk of glioblastoma in allele model (OR, 1.38; 95% CI, 1.00-1.89; P = 0.047) and dominant model (OR, 1.57; 95% CI, 1.05-2.35; P = 0.027), analysis respectively. Meanwhile, rs2297440 in RTEL1 gene showed an increased risk of glioma (OR, 1.30; 95% CI, 1.10-1.54; P = 0.002) and astrocytoma (OR, 1.26; 95% CI, 1.02-1.54; P = 0.029) in the allele model. In addition, we also observed a haplotype of "GCT" in the RTEL1 gene with an increased risk of astrocytoma (P = 0.005).


CONCLUSIONS
Polymorphisms in the XRCC5, RPA3 and RTEL1 genes, combinating with previous reaserches, are associated with glioma developing. However, those genes mutations may play different roles in the glioma, astrocytoma and glioblastoma, respectively.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University Xi'an 710069, China.
Tianbo
T
Jin
Department of Trauma, The Second Affiliated Hospital, Inner Mongolia Medical University Hohhot 010030, China.
Yuan
Y
Wang
Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University Xi'an 710038, China.
Gang
G
Li
National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University Xi'an 710069, China.
Shuli
S
Du
National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University Xi'an 710069, China.
Hua
H
Yang
National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University Xi'an 710069, China.
Tingting
T
Geng
Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine Xi'an 710061, China.
Peng
P
Hou
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University Xi'an 710069, China.
Yongkuan
Y
Gong
RPA3; RTEL1; XRCC5; astrocytoma; case-control study; glioblastoma; glioma