[Neuroprotection by noble gases: New developments and insights].
Noble gases are chemically inert elements, some of which exert biological activity. Experimental neuroprotection in particular has been widely shown for xenon, argon and helium. The underlying mechanisms of action are not yet fully understood. Besides an interference with neuronal ion-gated channels and cellular signaling pathways as well as anti-apoptotic effects, the modulation of neuroinflammation seems to play a crucial role. This review presents the current knowledge on neuroprotection by noble gases with a focus on interactions with the neuronal-glial network and neuroinflammation and the perspectives on clinical applications.
Klinik für Anästhesiologie, Universitätsklinikum Aachen, RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland. afahlenkamp@ukaachen.de.
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Fahlenkamp
Klinik für Anästhesiologie, Universitätsklinikum Aachen, RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
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Rossaint
Klinik für Anästhesiologie, Universitätsklinikum Aachen, RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
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Coburn
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D009434:Neural Pathways / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D000066829:Neuroprotection; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005741:Noble Gases / Q000494:pharmacology / Q000627:therapeutic use*
D018696:Neuroprotective Agents; D005741:Noble Gases
Apoptosis; Inflammation; Neuroglia; Neuron; Neuroprotective agents