Electroconvulsive Therapy in Multiple Sclerosis.
We performed a literature search regarding the safety and efficacy of electroconvulsive therapy in patients with multiple sclerosis and comorbid psychiatric symptoms. Literature review was conducted via PubMed databases. Of the cases we reviewed, most subjects with multiple sclerosis reported significant psychiatric symptom relief, with only a handful reporting neurologic deterioration. There was some evidence that active white matter lesions may be predictive of neurologic deterioration when electroconvulsive therapy is used in patients with multiple sclerosis. A brief description of the pathophysiology and effects of depression in patients with multiple sclerosis is also provided. Although no clinical recommendations or meaningful conclusions can be drawn without further investigation, the literature suggests that electroconvulsive therapy for treatment of psychiatric illnesses in patients with multiple sclerosis is safe and efficacious.
Dr. Steen is psychiatry resident at the University of Minnesota, Minneapolis; Dr. Narang is Staff Physician and Lead ECT Psychiatrist, Regions Hospital, Minneapolis-St. Paul, Minnesota; and Dr. Lippmann is Professor of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky.
Katie
K
Steen
Dr. Steen is psychiatry resident at the University of Minnesota, Minneapolis; Dr. Narang is Staff Physician and Lead ECT Psychiatrist, Regions Hospital, Minneapolis-St. Paul, Minnesota; and Dr. Lippmann is Professor of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky.
Puneet
P
Narang
Dr. Steen is psychiatry resident at the University of Minnesota, Minneapolis; Dr. Narang is Staff Physician and Lead ECT Psychiatrist, Regions Hospital, Minneapolis-St. Paul, Minnesota; and Dr. Lippmann is Professor of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky.
Steven
S
Lippmann
ECT; depression; electroconvulsive therapy; multiple sclerosis