Cough in Sarcoidosis.
Sarcoidosis is a granulomatous disorder that frequently affects the lungs. Cough is commonly reported by patients and can significantly reduce health-related quality of life. The mechanism of cough is unknown but airway inflammation, mechanical distortion from pulmonary fibrosis and disruption of the vagus nerve are possible. Recent evidence suggests cough reflex hypersensitivity may also be an important mechanism and predictor of the frequency of cough. The investigation of cough should evaluate common causes such as asthma, gastro-oesophageal reflux and rhinitis. In patients with suspected cough due to sarcoidosis, a trial of corticosteroids should be considered. The severity of cough should be evaluated with validated outcome measures such as visual analogue scales, cough severity diary, health-related quality of life questionnaires such as the Leicester Cough Questionnaire and objective cough monitors. Future studies are needed to identify targets for therapeutic development.
Division of Asthma, Allergy and Lung Biology, King's College London, Denmark Hill, London, SE9 5RS, UK.
Timothy
T
Tully
Division of Asthma, Allergy and Lung Biology, King's College London, Denmark Hill, London, SE9 5RS, UK. surinder.birring@nhs.net.
Surinder S
SS
Birring
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003371:Cough / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D011788:Quality of Life; D012018:Reflex / Q000502:physiology; D017565:Sarcoidosis, Pulmonary / Q000150:complications*
D000305:Adrenal Cortex Hormones
Cough; Cough reflex hypersensitivity; Health related quality of life; Sarcoidosis