EURObservational Research Programme: the Chronic Ischaemic Cardiovascular Disease Registry: Pilot phase (CICD-PILOT).
OBJECTIVE
Chronic ischaemic cardiovascular disease (CICD) is a major cause of mortality and morbidity worldwide. The primary objective of the CICD-Pilot registry was to describe the clinical characteristics and management modalities across Europe in a broad spectrum of patients with CICD.


RESULTS
The CICD-Pilot registry is an international prospective observational longitudinal registry, conducted in 100 centres from 10 countries selected to reflect the diversity of health systems and care attitudes across Europe. From April 2013 to December 2014, 2420 consecutive CICD patients with non-ST-elevation acute coronary syndrome (n = 755) and chronic stable coronary artery disease (n = 1464), of whom 933 (63.7%) were planned for elective coronary intervention, or with peripheral artery disease (PAD) (n = 201), were enrolled (30.5% female patients). Mean age was 66.6 ± 10.9 years. The following risk factors were reported: smoking 54.6%, diabetes mellitus 29.2%, hypertension 82.6%, and hypercholesterolaemia 74.1%. Assessment of cardiac function was made in 69.5% and an exercise stress test in 21.2% during/within 1 year preceding admission. New stress imaging modalities were applied in a minority of patients. A marked increase was observed at discharge in the rate of prescription of angiotensin-converting enzyme-inhibitors/angiotensin receptor blockers (82.8%), beta-blockers (80.2%), statins (92.7%), aspirin (90.3%), and clopidogrel (66.8%). Marked differences in clinical profile and treatment modalities were observed across the four cohorts.


CONCLUSIONS
The CICD-Pilot registry suggests that implementation of guideline-recommended therapies has improved since the previous surveys but that important heterogeneity exists in the clinical profile and treatment modalities in the different cohorts of patients enrolled with a broad spectrum of CICDs.
Department of Cardiology, Pitié-Salpêtrière Hospital, University Pierre and Marie Curie and IHU ICAN, Paris, France michel.komajda@psl.aphp.fr.
Michel
M
Komajda
2nd Medical Department with Cardiology and Intensive Care Medicine, Rudolfstiftung Hospital, Vienna, Austria.
Franz
F
Weidinger
Department of Cardiology, Pitié-Salpêtrière Hospital, University Pierre and Marie Curie and IHU ICAN, Paris, France.
Mathieu
M
Kerneis
Cardiology Unit, Department of Medicine, Solna, Karolinska University Hospital, Stockholm, Sweden.
Francesco
F
Cosentino
GVM Care and Research, Maria Cecilia Hospital, Cotignola, Italy.
Alberto
A
Cremonesi
Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, E.S. Health Science Foundation, Cotignola, Italy.
Roberto
R
Ferrari
Centre Cardiologique et Vasculaire, Thionville, France.
Serge
S
Kownator
DHU FIRE, Université Paris-Diderot, Hôpital Bichat, AP-HP, and INSERM, Paris U-1148, France.
Philippe Gabriel
PG
Steg
Maria Cecilia Hospital, GVM Care and Research, Ettore Sansavini Health Science Foundation, Cotignola, Italy.
Luigi
L
Tavazzi
Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
Marco
M
Valgimigli
2nd Department of Coronary Artery Disease, Institute of Cardiology, Warsaw, Poland.
Hanna
H
Szwed
2nd Department of Coronary Artery Disease, Institute of Cardiology, Warsaw, Poland.
Wojciech
W
Majda
Department of Cardiology, Ca' Foncello Hospital, Treviso, Italy.
Zoran
Z
Olivari
Department of Cardiology, University Hospital, Lille, France.
Eric
E
Van Belle
Cardiac Arrhythmias Department, Almazov Research Institute of Cardiology, Saint-Petersburg, Russia.
Evgeny Vladimirovich
EV
Shlyakhto
Latvian Center of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia.
Iveta
I
Mintale
Department of Cardiology, Hospital of the Lithuanian Health Science University, Kaunas, Lithuania.
Rimvydas
R
Slapikas
Medizinische Klinik I, Klinikum Fuerth, Fürth, Germany.
Harald
H
Rittger
Cardiology Department, Hospital De Santa Cruz, Centro Hospitalar De Lisboa Ocidental, Carnaxide, Portugal.
Miguel
M
Mendes
1st University Cardiology Clinic, Hippocratio Hospital, Athens, Greece.
Constantinos
C
Tsioufis
Department of Cardiology, Monza Hospital Centru Cardiovascular, Bucharest, Romania.
Serban
S
Balanescu
EURObservational Research Programme, European Society of Cardiology, Sophia-Antipolis, France.
Cécile
C
Laroche
EURObservational Research Programme, European Society of Cardiology, Sophia-Antipolis, France.
Aldo Pietro
AP
Maggioni
D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002908:Chronic Disease; D005060:Europe / Q000453:epidemiology; D005260:Female; D019983:Guideline Adherence; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000453:epidemiology* / Q000628:therapy; D010865:Pilot Projects; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D012042:Registries
D015415:Biomarkers; D002317:Cardiovascular Agents
Cardiac procedures; Drug therapy; Ischaemic cardiovascular disease; Management; Stable angina