The relationship between epicardial adipose tissue thickness and oxidative stress parameters in patients with isolated polycystic ovary syndrome.
OBJECTIVE
The aim of this study is to evaluate the correlation between epicardial adipose tissue thickness and oxidative stress parameters in patients with polycystic ovarian syndrome.


METHODS
The study included 35 patients with PCOS and 35 healthy women. Transthoracic echocardiography was used to measure the epicardial adipose tissue thickness (EATT) of all patients. For all patients, serum TOS, TAS, hs-CRP, and insulin levels were measured according to the literature, and the HOMA-IR values were calculated. Independent samples t-test, Pearson's correlation analysis, multivariate logistic regression analysis, and receiver operator characteristic curve (ROC) analysis were used in the statistical analysis.


RESULTS
Between the patient group and the control group, EATT was significantly higher in the PCOS group compared to the control group (5.4 ± 1.4 mm and 3.9 ± 1.6 mm, respectively; p < 0.001). Similarly, TOS, TAS, and hs-CRP levels were significantly higher in the PCOS group compared to the control group (p < 0.01 for all). The correlation analysis showed a significant positive correlation between EATT and TAS and hs-CRP (r = 0.349, p < 0.01 and r = 0.352, p < 0.01, respectively). Multivariate regression analysis showed a significant correlation between PCOS and EATT, TAS, and diastolic blood pressure (p < 0.05 for all).


CONCLUSIONS
Epicardial adipose tissue may play a major role in PCOS pathogenesis by leading to an increase in oxidative stress.
a Department of Cardiology .
Bülent
B
Demir
Hüseyin
H
Cengiz
Ismail
I
Ungan
Asuman
A
Gedikbasi
Gökhan
G
Karakoç
Esra
E
Demir
Nazan
N
Demir
D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D010496:Pericardium / Q000000981:diagnostic imaging*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D055815:Young Adult
Amenorrhea; insulin; ovary; polycystic ovary syndrome