Core-Shell MnSe@Bi2 Se3 Fabricated via a Cation Exchange Method as Novel Nanotheranostics for Multimodal Imaging and Synergistic Thermoradiotherapy.
MnSe@Bi2 Se3 core-shell nanostructures with highly integrated imaging and therapy functions are fabricated by a simple cation exchange method. Using those nanoparticles as a theranostic agent, a promise concept is further demonstrated to enhance conventional radiotherapy by: i) using X-ray absorbing agents to locally concentrate radiation energy and ii) employing near-infrared-light-triggered photothermal therapy to overcome hypoxia-associated radioresistance.
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
Guosheng
G
Song
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
Chao
C
Liang
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
Hua
H
Gong
School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
Meifang
M
Li
College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
Xianchuang
X
Zheng
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
Liang
L
Cheng
School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
Kai
K
Yang
College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
Xiqun
X
Jiang
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
Zhuang
Z
Liu
D000818:Animals; D001729:Bismuth / Q000737:chemistry; D001921:Brain / Q000473:pathology; D002412:Cations; D045744:Cell Line, Tumor; D008279:Magnetic Resonance Imaging / Q000379:methods; D008345:Manganese / Q000737:chemistry; D008807:Mice, Inbred BALB C; D064847:Multimodal Imaging; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D061848:Optical Imaging / Q000379:methods; D010789:Phototherapy / Q000379:methods; D011878:Radiotherapy / Q000379:methods; D012643:Selenium / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D051598:Whole Body Imaging / Q000379:methods
D002412:Cations; D008345:Manganese; D012643:Selenium; D001729:Bismuth
cation exchange; enhanced radiation therapy; hypoxia; photothermal therapy; synergistic effect