Analyzing large-scale samples highlights significant association between rs10411210 polymorphism and colorectal cancer.
Colorectal cancer (CRC) is the third most common form of cancer and the second leading cause of cancer-related death in the Western countries. In order to detect common CRC genetic variants, genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants. RHPN2 is located on 9q13.11, which encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. RHPN2 gene rs10411210 polymorphism was identified to be significantly associated with CRC in European ancestry. GWAS and candidate studies investigate whether rs10411210 polymorphism is associated with CRC risk in European, Asian and American populations. However, most studies reported no association. Evidence shows that RHPN2 rs10411210 variant may be a prognostic biomarker for patients with surgically resected CRC. Here we reevaluated this association using large-scale samples from 15 studies (131580 samples including 53564 CRC cases and 78016 controls) using meta-analysis method by searching the PubMed and Google Scholar databases. We did not identify significant heterogeneity among these 15 studies (P=0.4201 and I(2)=2.8%). Our results showed significant association between rs10411210 and CRC (P=9.17E-14, odds ratio (OR)=1.10, 95% confidence interval (CI) 1.07-1.13). In subgroup analysis, we found significant association between rs10411210 and CRC in European population with P=5.70E-09, OR=1.14, 95% CI 1.10-1.20 and Asian population with P=3.36E-07, OR=1.11, 95% CI 1.07-1.16, but not American population with P=0.0576, OR=1.05, 95% CI 1.00-1.09. Collectively, our analysis further highlights significant association between rs10411210 polymorphism and colorectal cancer.
Department of Intervention, The Affliated Tumor Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Dongfeng
D
He
Comprehensive Internal Medicine Therapy Area, The Affliated Tumor Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Lihong
L
Ma
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
Rennan
R
Feng
Department of Statistics, Rice University, Houston, TX, USA; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Liangcai
L
Zhang
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Yongshuai
Y
Jiang
Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China. Electronic address: yanqiaozhang@ems.hrbmu.edu.cn.
Yanqiao
Y
Zhang
Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China. Electronic address: liuguiyou1981@163.com.
Guiyou
G
Liu
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; C471419:RHPN2 protein, human
Colorectal cancer; Genome-wide association studies; Meta-analysis; rs10411210