Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity.
BACKGROUND
Psoriasis is a chronic skin disease with deregulation of proteins in the immune system. These proteins include members of the heterogeneous S100 family, which have been discussed as potential biomarkers for disease severity.


OBJECTIVE
The aim of this study was to evaluate the impact of S100A7, S100A8, S100A9 and S100A12 as possible markers for disease activity in patients with psoriasis skin disease.


METHODS
S100A7, S100A8, S100A9 and S100A12 mRNA expression was determined in the skin of patients with psoriasis and controls (N = 341) by gene expression analyses. In addition, S100 serum levels were investigated by ELISA in an independent cohort of psoriasis patients (i) untreated, with different manifestations (skin/joints), (ii) under treatment (etanercept) and (iii) healthy controls, (N = 55).


RESULTS
All S100-subtypes included are significantly upregulated in psoriasis skin lesions when compared with atopic dermatitis, lichen ruber and healthy donors. In untreated psoriasis patients, S100A12-serum levels showed the closest association with disease activity (PASI) (r = 0.542; P < 0.01). Serum levels decreased under treatment with etanercept (P < 0.05).


CONCLUSIONS
Among the investigated S100-proteins, S100A12 showed the closest association with disease activity and therapeutic response and might therefore provide a valuable biomarker for psoriasis.
Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.
D
D
Wilsmann-Theis
Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.
J
J
Wagenpfeil
Institute of Immunology, University of Muenster, Muenster, Germany.|Department of Paediatric Rheumatology and Immunology, University Children's Hospital Muenster, Muenster, Germany.
D
D
Holzinger
Institute of Immunology, University of Muenster, Muenster, Germany.
J
J
Roth
Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.
S
S
Koch
Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.
S
S
Schnautz
Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.
T
T
Bieber
Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.
J
J
Wenzel
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism*; D000067616:S100A12 Protein / Q000378:metabolism*; D055815:Young Adult
D015415:Biomarkers; D000067616:S100A12 Protein; C090441:S100A12 protein, human