Sericin/Poly(ethylcyanoacrylate) Nanospheres by Interfacial Polymerization for Enhanced Bioefficacy of Fenofibrate: In Vitro and In Vivo Studies.
Fenofibrate is a lipophilic drug used in hypercholesterolemia and hypertriglyceridemia as a lipid-regulating agent; however, it is characterized by poor water solubility and low dissolution rate, which result in a low oral bioavailability. In the present study, sericin/poly(ethylcyanoacrylate) nanospheres are synthesized by interfacial polymerization in aqueous media and investigated as a novel sericin-based delivery system for improved and enhanced oral bioefficacy of fenofibrate. The incorporation of sericin into the prepared cyanoacrylate nanoparticles and their spherical shape are confirmed by Lowry assay and scanning electron microscopy, respectively. Hydrophilic and mucoadhesive properties of the synthesized nanospheres are also evaluated. Finally, both in vitro release and in vivo studies are performed and the oral absorbable amount of fenofibrate is calculated to be higher than 70% when incorporated into the polymeric material, reducing the levels of total cholesterol (TC), triacylglycerols (TG), very low-density lipoproteins (VLDL), and low-density lipoproteins (LDL) compared to fenofibrate alone.
Department of Pharmacy, Health and Nutritional Sciences, and §Department of Informatics, Modeling, Electronics and Systems Engineering, University of Calabria , 87036 Rende (CS), Italy.
Ortensia I
OI
Parisi
Department of Pharmacy, Health and Nutritional Sciences, and §Department of Informatics, Modeling, Electronics and Systems Engineering, University of Calabria , 87036 Rende (CS), Italy.
Marco
M
Fiorillo
Department of Pharmacy, Health and Nutritional Sciences, and §Department of Informatics, Modeling, Electronics and Systems Engineering, University of Calabria , 87036 Rende (CS), Italy.
Luca
L
Scrivano
Department of Pharmacy, Health and Nutritional Sciences, and §Department of Informatics, Modeling, Electronics and Systems Engineering, University of Calabria , 87036 Rende (CS), Italy.
Maria S
MS
Sinicropi
Department of Pharmacy, Health and Nutritional Sciences, and §Department of Informatics, Modeling, Electronics and Systems Engineering, University of Calabria , 87036 Rende (CS), Italy.
Vincenza
V
Dolce
Department of Pharmacy, Health and Nutritional Sciences, and §Department of Informatics, Modeling, Electronics and Systems Engineering, University of Calabria , 87036 Rende (CS), Italy.
Domenico
D
Iacopetta
Department of Pharmacy, Health and Nutritional Sciences, and §Department of Informatics, Modeling, Electronics and Systems Engineering, University of Calabria , 87036 Rende (CS), Italy.
Francesco
F
Puoci
Department of Pharmacy, Health and Nutritional Sciences, and §Department of Informatics, Modeling, Electronics and Systems Engineering, University of Calabria , 87036 Rende (CS), Italy.
Anna R
AR
Cappello
D000818:Animals; D003487:Cyanoacrylates / Q000737:chemistry*; D011345:Fenofibrate / Q000008:administration & dosage / Q000737:chemistry*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000737:chemistry*; D066298:In Vitro Techniques; D008297:Male; D008855:Microscopy, Electron, Scanning; D054118:Nanospheres; D058105:Polymerization; D051381:Rats; D017208:Rats, Wistar; D047030:Sericins / Q000737:chemistry*
D003487:Cyanoacrylates; D000960:Hypolipidemic Agents; D047030:Sericins; C558475:poly(ethylcyanoacrylate); D011345:Fenofibrate