Primary peripheral T-cell lymphoma, not otherwise specified, of the central nervous system in a child.
Primary peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is a rare disease that infrequently involves the central nervous system (CNS), and it is even rarer in pediatric patients. Here, we report of a 13-year-old male with primary CNS PTCL-NOS who exhibited a malignant clinical course with recurrence after radiochemotherapy followed by bone marrow transplantation; he died 43 months after diagnosis. Pathology revealed the proliferation of cytotoxic T-cells and clonal T-cell receptor gene rearrangements. Although the optimal therapy for PTCL remains controversial, intensive radiochemotherapy may be required for some patients.
Department of Neurosurgery, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan. momota-nsu@umin.ac.jp.|Division of Innovative Cancer Therapy, Department of Surgical Neuro-Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. momota-nsu@umin.ac.jp.
Hiroyuki
H
Momota
Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan.
Seiichi
S
Kato
Department of Neurosurgery, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan.
Masazumi
M
Fujii
Department of Neurosurgery, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan.
Takashi
T
Tsujiuchi
Department of Pediatrics, Nagoya University Hospital, Nagoya, Japan.
Yoshiyuki
Y
Takahashi
Department of Pediatrics, Nagoya University Hospital, Nagoya, Japan.
Seiji
S
Kojima
Department of Neurosurgery, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan.
Toshihiko
T
Wakabayashi
D000293:Adolescent; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D017809:Fatal Outcome; D015321:Gene Rearrangement; D019672:Genes, T-Cell Receptor / Q000235:genetics; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local; D011854:Radiochemistry
Central nervous system; Pediatric; Peripheral T-cell lymphoma; Radiochemotherapy