Predictors for a positive outcome of adapted clinical dry bed training in adolescents and adults with enuresis.
Adapted Dry Bed Training (Adapted DBT) has been shown to be effective in therapy-resistant adolescents and adults with enuresis. Given the substantial impact of enuresis and the time-consuming nature of Adapted DBT, we investigated which patients benefited most from Adapted DBT. Therefore, we identified predictors for a successful treatment response to Adapted DBT in this population.



Retrospective cohort study in 907 consecutive patients, aged 11-42 years, subjected to in-hospital Adapted DBT in our Dry Bed Center between January 2003 and July 2013. Outcome was defined as treatment success after six months (primary outcome) and six weeks. Results of logistic regression analyses are presented in odds ratios and 95% confidence intervals.



Predictors for a successful treatment response to Adapted DBT in adolescents and adults with enuresis after six months are: gender (female), initial degree of enuresis (mild: 0-3 nights/week), current diaper use, never used anticholinergics in the past, and degree of enuresis six weeks after training. Predictors for successful treatment response after six weeks are: gender and initial degree of enuresis only.



The low explained variance of our model, showing that many other factors, not included in our study, could be of interest in the prediction of success.



Several factors that predicted a successful treatment response of Adapted DBT after six weeks and six months were identified. However, the low explained variance of our model suggests that other non-identified factors are also important in predicting outcome. Neurourol. Urodynam. 35:1006-1010, 2016. © 2015 Wiley Periodicals, Inc.
Department of Urology, Isala klinieken, Zwolle, Netherlands. ilsehofmeester@gmail.com.|Dry Bed Center, Noorderboog hospital, Meppel, Netherlands. ilsehofmeester@gmail.com.|Pediatric Urology Centre, Department of Urology, Radboudumc, Amalia Children's Hospital, Radboud University Medical Centre, Nijmegen, Netherlands. ilsehofmeester@gmail.com.|Netherlands Institute of Health Sciences (NIHES), Erasmus Medical Centre, Rotterdam, Netherlands. ilsehofmeester@gmail.com.
Ilse
I
Hofmeester
Department of General Practice, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands.
Boudewijn J
BJ
Kollen
Department of Urology, Isala klinieken, Zwolle, Netherlands.
Martijn G
MG
Steffens
Department of Urology, Isala klinieken, Zwolle, Netherlands.|Dry Bed Center, Noorderboog hospital, Meppel, Netherlands.
Jan Willem
JW
van Capelle
Dry Bed Center, Noorderboog hospital, Meppel, Netherlands.
Zwaan
Z
Mulder
Pediatric Urology Centre, Department of Urology, Radboudumc, Amalia Children's Hospital, Radboud University Medical Centre, Nijmegen, Netherlands.
Wouter F J
WF
Feitz
Department of General Practice, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands.
Marco H
MH
Blanker
D000293:Adolescent; D000328:Adult; D002648:Child; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D015331:Cohort Studies; D041382:Diapers, Adult; D004775:Enuresis / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D053206:Nocturnal Enuresis / Q000188:drug therapy; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D018680:Cholinergic Antagonists
adolescent; alarm therapy; bedwetting; dry bed training; enuresis; monosymptomatic; non-monosymptomatic; young adult