Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents.
Abnormal connectivity patterns have frequently been reported as involved in pathological mental states. However, most studies focus on "static," stationary patterns of connectivity, which may miss crucial biological information. Recent methodological advances have allowed the investigation of dynamic functional connectivity patterns that describe non-stationary properties of brain networks. Here, we introduce a novel graphical measure of dynamic connectivity, called time-varying eigenvector centrality (tv-EVC). In a sample 655 children and adolescents (7-15 years old) from the Brazilian "High Risk Cohort Study for Psychiatric Disorders" who were imaged using resting-state fMRI, we used this measure to investigate age effects in the temporal in control and default-mode networks (CN/DMN). Using support vector regression, we propose a network maturation index based on the temporal stability of tv-EVC. Moreover, we investigated whether the network maturation is associated with the overall presence of behavioral and emotional problems with the Child Behavior Checklist. As hypothesized, we found that the tv-EVC at each node of CN/DMN become more stable with increasing age (P < 0.001 for all nodes). In addition, the maturity index for this particular network is indeed associated with general psychopathology in children assessed by the total score of Child Behavior Checklist (P = 0.027). Moreover, immaturity of the network was mainly correlated with externalizing behavior dimensions. Taken together, these results suggest that changes in functional network dynamics during neurodevelopment may provide unique insights regarding pathophysiology.
Center of Mathematics, Computation and Cognition, Universidade Federal Do ABC, Santo Andre, Brazil.|Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|Department of Radiology, School of Medicine, University of Sao Paulo, São Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
João Ricardo
JR
Sato
Center of Mathematics, Computation and Cognition, Universidade Federal Do ABC, Santo Andre, Brazil.|Department of Radiology, School of Medicine, University of Sao Paulo, São Paulo, Brazil.
Claudinei Eduardo
CE
Biazoli
National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.|Department of Psychiatry, Federal University of Rio Grande Do Sul, Porto Alegre, Brazil.
Giovanni Abrahão
GA
Salum
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
Ary
A
Gadelha
Institute of Psychiatry, King's College London, London, United Kingdom.
Nicolas
N
Crossley
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Theodore D
TD
Satterthwaite
Department of Radiology, School of Medicine, University of Sao Paulo, São Paulo, Brazil.|Bioinformatics Program, Institute of Mathematics and Statistics, University of Sao Paulo, São Paulo, Brazil.
Gilson
G
Vieira
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
André
A
Zugman
National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.|Department of Psychiatry, Federal University of Rio Grande Do Sul, Porto Alegre, Brazil.
Felipe Almeida
FA
Picon
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
Pedro Mario
PM
Pan
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.|Department of Psychiatry, School of Medicine, University of Sao Paulo, São Paulo, Brazil.
Marcelo Queiroz
MQ
Hoexter
National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.|Department of Psychiatry, Federal University of Rio Grande Do Sul, Porto Alegre, Brazil.
Mauricio
M
Anés
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
Luciana Monteiro
LM
Moura
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
Marco Antonio Gomes
MA
Del'aquilla
Department of Radiology, School of Medicine, University of Sao Paulo, São Paulo, Brazil.
Edson
E
Amaro
Institute of Psychiatry, King's College London, London, United Kingdom.
Philip
P
McGuire
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
Acioly L T
AL
Lacerda
National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.|Department of Psychiatry, Federal University of Rio Grande Do Sul, Porto Alegre, Brazil.
Luis Augusto
LA
Rohde
National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.|Department of Psychiatry, School of Medicine, University of Sao Paulo, São Paulo, Brazil.
Euripedes Constantino
EC
Miguel
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
Andrea Parolin
AP
Jackowski
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal De Sao Paulo (UNIFESP), Sao Paulo, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
Rodrigo Affonseca
RA
Bressan
D000293:Adolescent; D000367:Age Factors; D000987:Antisocial Personality Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D016571:Neural Networks, Computer; D009434:Neural Pathways / Q000502:physiology
connectivity; default-mode network; development; neurodevelopment; psychopathology