Mining the Chemical Space: Application of 2/4-Nitrobenzenesulfonamides in Solid-Phase Synthesis.
Polymer-supported benzenesulfonamides prepared from various immobilized primary amines and 2/4-nitrobenzenesulfonyl chloride have been used as key intermediates in different chemical transformations, including unusual rearrangements to yield a number of diverse privileged scaffolds. This review summarizes individual strategies in their application to date.
Department of Organic Chemistry, Institute of Molecular and Translational Medicine, Faculty of Science, Palacky University , 17 listopadu 12, 771 46 Olomouc, Czech Republic.
Veronika
V
Fülöpová
Department of Organic Chemistry, Institute of Molecular and Translational Medicine, Faculty of Science, Palacky University , 17 listopadu 12, 771 46 Olomouc, Czech Republic.
Miroslav
M
Soural
D000588:Amines / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D009578:Nitrobenzenes / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
C518227:4-nitrobenzenesulfonyl chloride; D000588:Amines; D009578:Nitrobenzenes; D011108:Polymers; D013449:Sulfonamides
2-nitrobenzenesulfonyl chloride; 4-nitrobenzenesulfonyl chloride; C-arylation; Fukuyama alkylation; Fukuyama−Mitsunobu alkylation; N-arylation; protective group; rearrangement; solid-phase synthesis