Utility of serum des-gamma-carboxyprothrombin in the diagnosis of hepatocellular carcinoma among Nigerians, a case-control study.
BACKGROUND
Hepatocellular Carcinoma (HCC) is a common malignancy occurring globally but with a dismal prognosis. Des-gamma-carboxyprothrombin (DCP) has been reported to be more sensitive and specific than Alpha-fetoprotein (AFP) in the diagnosis of HCC among the White population. Its efficacy among the Black population is yet to be established. The aim of this study therefore, was to determine the relative sensitivity and specificity of des-gamma-carboxyprothrombin and alpha-fetoprotein in the diagnosis of hepatocellular carcinoma in a cohort of Nigerian patients presenting at a single referral centre.


METHODS
Cross-sectional case-control study was carried out using 62 HCC patients and 57 controls with benign liver diseases including chronic hepatitis and compensated liver cirrhosis. Both DCP and AFP were tested using enzyme immunoassay methods.


RESULTS
Sixty-nine percent of the HCC patients presented with tumour sizes >5 cm while 31% presented with tumour sizes 3-5 cm. No patient presented with tumour sizes <3 cm. The sensitivity and specificity of DCP were 96.8% and 98.3% respectively, based on a Receiver operating characteristic (ROC) curve - derived optimum cut-off level of >140mAU/ml. Similarly, the sensitivity and specificity of AFP were 62.9% and 93.3% at an ROC - derived optimum cut-off level of 18mAU/ml. The area under the receiver operating characteristic curve (AUROC) for DCP was 0.99 and was significantly larger than that of AFP which was 0.85 (p < 0.001).


CONCLUSIONS
In conclusion, the utility of DCP for the diagnosis of HCC among Nigerian patients was higher than that of AFP for large tumours with diameter ≥3 cm.
Department of Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria. draette@yahoo.com.
Akpakip I
AI
Ette
Department of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria. dennisndububa@yahoo.co.uk.
Dennis A
DA
Ndububa
Department of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria. olusegunadekanle@yahoo.co.uk.
Olusegun
O
Adekanle
Department of Medicine, University of Uyo, Uyo, Nigeria. udekrikpo@yahoo.com.
Udeme
U
Ekrikpo
D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D044383:Black People; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D011498:Protein Precursors / Q000097:blood*; D011516:Prothrombin; D012372:ROC Curve; D047368:Tumor Burden; D000509:alpha-Fetoproteins / Q000378:metabolism*
D015415:Biomarkers; D011498:Protein Precursors; D000509:alpha-Fetoproteins; C008208:acarboxyprothrombin; D011516:Prothrombin