Can the Onset of Type 2 Diabetes Be Delayed by a Group-Based Lifestyle Intervention in Women with Prediabetes following Gestational Diabetes Mellitus (GDM)? Findings from a Randomized Control Mixed Methods Trial.
OBJECTIVE
To evaluate a 12-week group-based lifestyle intervention programme for women with prediabetes following gestational diabetes (GDM).


METHODS
A two-group, mixed methods randomized controlled trial in which 50 women with a history of GDM and abnormal glucose tolerance postpartum were randomly assigned to intervention (n = 24) or wait control (n = 26) and postintervention qualitative interviews with participants.


METHODS
Modifiable biochemical, anthropometric, behavioural, and psychosocial risk factors associated with the development of type 2 diabetes. The primary outcome variable was the change in fasting plasma glucose (FPG) from study entry to one-year follow-up.


RESULTS
At one-year follow-up, the intervention group showed significant improvements over the wait control group on stress, diet self-efficacy, and quality of life. There was no evidence of an effect of the intervention on measures of biochemistry or anthropometry; the effect on one health behaviour, diet adherence, was close to significance.


CONCLUSIONS
Prevention programmes must tackle the barriers to participation faced by this population; home-based interventions should be investigated. Strategies for promoting long-term health self-management need to be developed and tested.
School of Medicine, Clinical Sciences Institute, National University of Ireland Galway, Galway, Ireland.
Angela
A
O'Dea
School of Medicine, Clinical Sciences Institute, National University of Ireland Galway, Galway, Ireland.
Marie
M
Tierney
School of Psychology, National University of Ireland Galway, Galway, Ireland.
Brian E
BE
McGuire
HRB Clinical Research Facility, National University of Ireland Galway, Galway, Ireland.
John
J
Newell
Discipline of General Practice, School of Medicine, National University of Ireland Galway, Galway, Ireland.
Liam G
LG
Glynn
Croí-The West of Ireland Cardiac Foundation, Croí Heart and Stroke Centre, Moyola Lane, Newcastle, Galway, Ireland.
Irene
I
Gibson
School of Medicine, Clinical Sciences Institute, National University of Ireland Galway, Galway, Ireland.
Eoin
E
Noctor
J.E. Cairnes School of Business & Economics, National University of Ireland Galway, Cairnes Building, Galway, Ireland.
Andrii
A
Danyliv
Cardiovascular Medicine, International Centre for Circulatory Health, Imperial College London, London W2 1LA, UK.
Susan B
SB
Connolly
School of Medicine, Clinical Sciences Institute, National University of Ireland Galway, Galway, Ireland.
Fidelma P
FP
Dunne
D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D016640:Diabetes, Gestational / Q000503:physiopathology*; D004032:Diet; D005260:Female; D018149:Glucose Intolerance / Q000150:complications; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D008019:Life Style; D010349:Patient Compliance; D049590:Postpartum Period; D011236:Prediabetic State / Q000097:blood*; D011247:Pregnancy; D011788:Quality of Life; D012307:Risk Factors; D016896:Treatment Outcome
D001786:Blood Glucose