Successful Treatment of Lupus Cerebrovascular Disease with Mycophenolate Mofetil.
We report a case of neuropsychiatric systemic lupus erythematosus successfully treated with mycophenolate mofetil (MMF). The patient was a 40-year-old female who maintained with 7 mg of prednisolone plus 100 mg of azathioprine (AZ) per day. According to transient ischemic attack that occurred repeatedly and an elevated level of interleukin-6 (IL-6) in spinal fluid, she was diagnosed as having neuropsychiatric systemic lupus erythematosus (NPSLE). Initial increase in doses of prednisolone and AZ to 20 mg and 150 mg per day, respectively, was ineffective. After switching from AZ to MMF, her symptoms of NPSLE completely resolved with marked improvement of the IL-6 level in her spinal fluid, suggesting that MMF was effective.
Division of Rheumatology, Matsuyama Red Cross Hospital, Japan.
Kazuhiko
K
Higashioka
Kenji
K
Yoshida
Kensuke
K
Oryoji
Kazuo
K
Kamada
Shinichi
S
Mizuki
Hiroshi
H
Tsukamoto
Eisuke
E
Yokota
Koichi
K
Akashi
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000378:metabolism*; D002546:Ischemic Attack, Transient / Q000209:etiology; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
C508600:IL6 protein, human; D007166:Immunosuppressive Agents; D015850:Interleukin-6; D009173:Mycophenolic Acid; D001379:Azathioprine