Deciphering the roles of acyl-CoA-binding proteins in plant cells.
Lipid trafficking is vital for metabolite exchange and signal communications between organelles and endomembranes. Acyl-CoA-binding proteins (ACBPs) are involved in the intracellular transport, protection, and pool formation of acyl-CoA esters, which are important intermediates and regulators in lipid metabolism and cellular signaling. In this review, we highlight recent advances in our understanding of plant ACBP families from a cellular and developmental perspective. Plant ACBPs have been extensively studied in Arabidopsis thaliana (a dicot) and to a lesser extent in Oryza sativa (a monocot). Thus far, they have been detected in the plasma membrane, vesicles, endoplasmic reticulum, Golgi apparatus, apoplast, cytosol, nuclear periphery, and peroxisomes. In combination with biochemical and molecular genetic tools, the widespread subcellular distribution of respective ACBP members has been explicitly linked to their functions in lipid metabolism during development and in response to stresses. At the cellular level, strong expression of specific ACBP homologs in specialized cells, such as embryos, stem epidermis, guard cells, male gametophytes, and phloem sap, is of relevance to their corresponding distinct roles in organ development and stress responses. Other interesting patterns in their subcellular localization and spatial expression that prompt new directions in future investigations are discussed.
School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China.
Shiu-Cheung
SC
Lung
School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China. mlchye@hkucc.hku.hk.
Mee-Len
ML
Chye
D000105:Acetyl Coenzyme A / Q000378:metabolism*; D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D003066:Coenzyme A Ligases / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D012275:Oryza / Q000378:metabolism; D059828:Plant Cells / Q000378:metabolism*
C532782:ACBP6 protein, Arabidopsis; D029681:Arabidopsis Proteins; D002352:Carrier Proteins; D005227:Fatty Acids; D000105:Acetyl Coenzyme A; D003066:Coenzyme A Ligases
Acyl-CoA esters; Fatty acids; Lipid transporters; Phospholipids; Plant development; Subcellular localization