Eight International London Cough Symposium 2014: Cough hypersensitivity syndrome as the basis for chronic cough.
At the Eighth International London Cough Conference held in London in July 2014, the focus was on the relatively novel concept of cough hypersensitivity syndrome (CHS) as forming the basis of chronic cough. This concept has been formulated following understanding of the neuronal pathways for cough and a realisation that not all chronic cough is usually associated with a cause. The CHS is defined by troublesome coughing triggered by low level of thermal, mechanical or chemical exposure. It also encompasses other symptoms or sensations such as laryngeal hypersensitivity, nasal hypersensitivity and possibly also symptoms related to gastrooesopahgeal reflux. The pathophysiologic basis of the CHS is now being increasingly linked to an enhancement of the afferent pathways of the cough reflex both at the peripheral and central levels. Mechanisms involved include the interactions of inflammatory mechanisms with cough sensors in the upper airways and with neuronal pathways of cough, associated with a central component. Tools for assessing CHS in the clinic need to be developed. New drugs may be developed to control CHS. A roadmap is suggested from the inception of the CHS concept towards the development of newer antitussives at the Symposium.
Experimental Studies, National Heart and Lung Institute, Imperial College London, UK; Royal Brompton NIHR Biomedical Research Unit, London, UK. Electronic address: f.chung@imperial.ac.uk.
Kian Fan
KF
Chung
The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.
Brendan
B
Canning
Department of Respiratory Medicine, Centre for Infection and Immunity, Queen's University Belfast, UK.
Lorcan
L
McGarvey
D000542:Alveolitis, Extrinsic Allergic / Q000150:complications* / Q000503:physiopathology*; D000818:Animals; D000996:Antitussive Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003371:Cough / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology
D000996:Antitussive Agents
Amitryptiline; Antitussives; Chronic cough; Cough hypersensitivity syndrome; Gabapentin; Laryngeal hypersensitivity; Neural pathways; Neuroinflammation; P2X2/3 receptors; TRPA1; TRPV1