Hyperthermia: an effective strategy to induce apoptosis in cancer cells.
Heat has been used as a medicinal and healing modality throughout human history. The combination of hyperthermia (HT) with radiation and anticancer agents has been used clinically and has shown positive results to a certain extent. However, the clinical results of HT treatment alone have been only partially satisfactory. Cell death following HT treatment is a function of both temperature and treatment duration. HT induces cancer cell death through apoptosis; the degree of apoptosis and the apoptotic pathway vary in different cancer cell types. HT-induced reactive oxygen species production are responsible for apoptosis in various cell types. However, the underlying mechanism of signal transduction and the genes related to this process still need to be elucidated. In this review, we summarize the molecular mechanism of apoptosis induced by HT, enhancement of heat-induced apoptosis, and the genetic network involved in HT-induced apoptosis.
Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan.
Kanwal
K
Ahmed
Division of Molecular Genetic Research, Life Science Research Center, University of Toyama, Toyama, 930-0194, Japan.
Yoshiaki
Y
Tabuchi
Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan. kondot@med.u-toyama.ac.jp.
Takashi
T
Kondo
D000818:Animals; D017209:Apoptosis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D006979:Hyperthermia, Induced; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species
Apoptosis; Genetic network; Hyperthermia; ROS