PHARMACOKINETIC PROPERTIES OF A SINGLE ADMINISTRATION OF ORAL GABAPENTIN IN THE GREAT HORNED OWL (BUBO VIRGINIANUS).
Gabapentin (1-[aminomethyl] cyclohexane acetic acid) is a γ-aminobutyric acid analogue that has been shown to be efficacious for neuropathic pain control in humans. Plasma gabapentin concentrations >2 μg/ml are considered effective in treating epilepsy in humans and are suggested to provide analgesia for neuropathic pain. This study investigated the pharmacokinetics of a single oral dose of gabapentin suspension (11 mg/kg) in great horned owls ( Bubo virginianus ). Plasma gabapentin concentrations were determined in six healthy birds for 48 hr using high-performance liquid chromatography with mass spectrometric detection. Plasma gabapentin concentrations were estimated by noncompartmental pharmacokinetic analysis. The harmonic mean (±SD) maximum concentration (Cmax), time to maximum concentration (Tmax), and elimination half-life (tv2λZ) for gabapentin (11 mg/kg) were 6.17±0.83 μg/ml, 51.43±5.66 min, and 264.60±69.35 min, respectively. In this study, plasma gabapentin concentrations were maintained above 2 μg/ml for 528 min (8.8 hr), suggesting that gabapentin administered orally every 8 hr may be appropriate in great horned owls.
Taylor J
TJ
Yaw
Bianca A
BA
Zaffarano
Andrew
A
Gall
June E
JE
Olds
Larry
L
Wulf
Efthimia
E
Papastavros
Johann F
JF
Coetzee
D000588:Amines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000700:Analgesics / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D019540:Area Under Curve; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000077206:Gabapentin; D006207:Half-Life; D020305:Strigiformes / Q000097:blood*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin
Analgesia; Bubo virginianus; gabapentin; great horned owls; neuropathic pain; pharmacokinetics