A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation.
Myeloperoxidase (MPO)-generated halogenating molecules, such as hypochlorous acid and hypobromous acid (HOBr), in inflammatory regions are postulated to contribute to disease progression. In this study, we showed that ergothioneine (EGT), derived from an edible mushroom, inhibited MPO activity as well as the formation of 8-bromo-2'-deoxyguanosine in vitro. The HOBr scavenging effect of EGT is higher than those of ascorbic acid and glutathione. We initially observed that the administration of Coprinus comatus, an edible mushroom containing a high amount of EGT, inhibited the UV-B-induced inflammatory responses and DNA halogenation, suggesting that EGT is a promising anti-inflammatory agent from mushrooms.
a Graduate School of Environmental and Life Science , Okayama University , Okayama , Japan.|b Graduate School of Bioagricultural Sciences , Nagoya University , Nagoya , Japan.
Takashi
T
Asahi
b Graduate School of Bioagricultural Sciences , Nagoya University , Nagoya , Japan.|c HealthCare Systems Co., Ltd. , Tokyo , Japan.
Xiaohong
X
Wu
d Oryza Oil & Fat Chemical Co., Ltd. , Ichinomiya , Japan.
Hiroshi
H
Shimoda
e Faculty of Pharmacy, Department of Pharmacy , Meijo University , Nagoya , Japan.
Shinsuke
S
Hisaka
f Iwade Research Institute of Mycology , Tsu , Japan.
Etsuko
E
Harada
g Hokkaido University of Education , Asahikawa , Japan.
Tomomi
T
Kanno
a Graduate School of Environmental and Life Science , Okayama University , Okayama , Japan.
Yoshimasa
Y
Nakamura
h School of Human Science and Environment , University of Hyogo , Himeji , Japan.
Yoji
Y
Kato
b Graduate School of Bioagricultural Sciences , Nagoya University , Nagoya , Japan.|i Faculty of Psychological and Physical Science , Aichi Gakuin University , Nissin , Japan.
Toshihiko
T
Osawa
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001959:Bromates / Q000037:antagonists & inhibitors / Q000378:metabolism; D004247:DNA / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D004880:Ergothioneine / Q000302:isolation & purification / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology; D054879:Halogenation / Q000187:drug effects; D006997:Hypochlorous Acid / Q000037:antagonists & inhibitors / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009195:Peroxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects
C439365:8-bromo-2'-deoxyguanosine; D000893:Anti-Inflammatory Agents; D001959:Bromates; D006997:Hypochlorous Acid; D004247:DNA; D004880:Ergothioneine; D009195:Peroxidase; D003849:Deoxyguanosine; D005978:Glutathione; C027664:hypobromous acid; D001205:Ascorbic Acid
anti-inflammatory agent; ergothioneine; hypobromous acid; mushroom; myeloperoxidase