Dexmedetomidine and propofol infusion on sedation characteristics in patients undergoing sciatic nerve block in combination with femoral nerve block via anterior approach.
OBJECTIVE
Dexmedetomidine is an α-2 adrenergic agonist having wide range of effects including sedation in mammalian brain, and has analgesic as well as sympatholytic properties. This study aimed to compare the effects of dexmedetomidine and propofol infusion on sedation characteristics in patients undergoing combined sciatic nerve and femoral nerve block via anterior approach for lower limb orthopedic procedure.


METHODS
Forty patients, who were between 18 and 65 years old, this study was made at anesthesiology clinic of Bağcılar training and research hospital in 08 September 2011 to 07 June 2012, and underwent surgical procedure due to fractures lateral and medial malleol, were included. Sciatic nerve and femoral nerve block were conducted with an anterior approach on all patients included in the study, with an ultrasonography. The patients were randomly divided into dexmedetomidine [Group D (n=20); 0.5μgkg(-1)h(-1)] and propofol [Group P (n=20); 3mgkg(-1)h(-1)] infusion groups.


RESULTS
The vital findings and intra-operative Ramsay sedation scale values were similar in both groups. Time taken for sedation to start and time required for sedation to become over of Group D were significantly higher than those of Group P (p<0.001 for each).


CONCLUSIONS
Substitution of dexmedetomidine instead of propofol prolongs the times to start of sedation, the times to end of sedation and duration of sedation.
Anesthesiology and Reanimation Clinic, Bağcılar Training and Research Hospital, Istanbul, Turkey. Electronic address: akyektas722000@yahoo.co.uk.
Abdulkadir
A
Yektaş
Anesthesiology and Reanimation Clinic, Bağcılar Training and Research Hospital, Istanbul, Turkey.
Funda
F
Gümüş
Anesthesiology and Reanimation Clinic, Bağcılar Training and Research Hospital, Istanbul, Turkey.
Ayşin
A
Alagol
D000328:Adult; D016292:Procedural Sedation; D020927:Dexmedetomidine / Q000494:pharmacology*; D005260:Female; D005267:Femoral Nerve; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D015742:Propofol / Q000494:pharmacology*; D012584:Sciatic Nerve
D020927:Dexmedetomidine; D015742:Propofol
Bloqueio de nervo; Dexmedetomidina; Dexmedetomidine; Nerve block; Propofol; Sedation; Sedação