Hepatitis A complicated with acute renal failure and high hepatocyte growth factor: A case report.
A 58-year-old man was admitted to our hospital. Laboratory data showed severe liver injury and that the patient was positive for immunoglobulin M anti-hepatitis A virus (HAV) antibodies. He was also complicated with severe renal dysfunction and had an extremely high level of serum hepatocyte growth factor (HGF). Therefore, he was diagnosed with severe acute liver failure with acute renal failure (ARF) caused by HAV infection. Prognosis was expected to be poor because of complications by ARF and high serum HGF. However, liver and renal functions both improved rapidly without intensive treatment, and he was subsequently discharged from our hospital on the 21(st) hospital day. Although complication with ARF and high levels of serum HGF are both important factors predicting poor prognosis in acute liver failure patients, the present case achieved a favorable outcome. Endogenous HGF might play an important role as a regenerative effector in injured livers and kidneys.
Shinji Oe, Michihiko Shibata, Koichiro Miyagawa, Yuichi Honma, Masaaki Hiura, Shintaro Abe, Masaru Harada, Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Shinji
S
Oe
Shinji Oe, Michihiko Shibata, Koichiro Miyagawa, Yuichi Honma, Masaaki Hiura, Shintaro Abe, Masaru Harada, Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Michihiko
M
Shibata
Shinji Oe, Michihiko Shibata, Koichiro Miyagawa, Yuichi Honma, Masaaki Hiura, Shintaro Abe, Masaru Harada, Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Koichiro
K
Miyagawa
Shinji Oe, Michihiko Shibata, Koichiro Miyagawa, Yuichi Honma, Masaaki Hiura, Shintaro Abe, Masaru Harada, Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Yuichi
Y
Honma
Shinji Oe, Michihiko Shibata, Koichiro Miyagawa, Yuichi Honma, Masaaki Hiura, Shintaro Abe, Masaru Harada, Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Masaaki
M
Hiura
Shinji Oe, Michihiko Shibata, Koichiro Miyagawa, Yuichi Honma, Masaaki Hiura, Shintaro Abe, Masaru Harada, Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Shintaro
S
Abe
Shinji Oe, Michihiko Shibata, Koichiro Miyagawa, Yuichi Honma, Masaaki Hiura, Shintaro Abe, Masaru Harada, Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Masaru
M
Harada
D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D015415:Biomarkers / Q000097:blood; D006506:Hepatitis A / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D035922:Hepatitis A Antibodies / Q000097:blood; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D017114:Liver Failure, Acute / Q000097:blood / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
D015415:Biomarkers; C066855:HGF protein, human; D035922:Hepatitis A Antibodies; D007075:Immunoglobulin M; D017228:Hepatocyte Growth Factor
Acute hepatitis; Acute renal failure; Hepatitis A virus; Hepatocyte growth factor