Bioresorbable vascular scaffold overlap evaluation with optical coherence tomography after implantation with or without enhanced stent visualization system (WOLFIE study): a two-centre prospective comparison.
To assess if enhanced stent visualization (ESV)-guided implantation of overlapping bioresorbable vascular scaffold (BVS) is superior to angiography alone-guided implantation in the reduction of overlap length. WOLFIE is a two-centre prospective open study enrolling 30 patients treated with implantation of at least two overlapping BVS. In the first centre (London), BVS implantation was guided by conventional angiography, while in the second centre (Ferrara), an ESV system was systematically employed. The primary endpoint of the study was overlap length. Secondary endpoints were: stacked struts number, area, thickness, and amount of clusters. In the ESV-guided group, overlap length was significantly lower compared to angiography-guided group [0.9 (0.6-1.8) vs. 2.2 (1.3-3.2) mm, p = 0.02]. Similarly, all secondary endpoints were significantly reduced. ESV-guided implantation of overlapping BVS is safe and effective in minimizing both overlap length and number of stacked struts.
Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Via Aldo Moro 8, Cona, Ferrara, FE, Italy. bscsmn@unife.it.
Simone
S
Biscaglia
Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Via Aldo Moro 8, Cona, Ferrara, FE, Italy.|LTTA Centre, Ferrara, Italy.
Gianluca
G
Campo
Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Via Aldo Moro 8, Cona, Ferrara, FE, Italy.
Matteo
M
Tebaldi
Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Via Aldo Moro 8, Cona, Ferrara, FE, Italy.
Carlo
C
Tumscitz
Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Via Aldo Moro 8, Cona, Ferrara, FE, Italy.
Rita
R
Pavasini
Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Via Aldo Moro 8, Cona, Ferrara, FE, Italy.
Luca
L
Fileti
Interventional Cardiology, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.|NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
Gioel G
GG
Secco
NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
Carlo
C
Di Mario
Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Via Aldo Moro 8, Cona, Ferrara, FE, Italy.|LTTA Centre, Ferrara, Italy.|Maria Cecilia Hospital, GVM Care & Research, E.S.: Health Science Foundation, Cotignola, Italy.
Roberto
R
Ferrari
D020341:Absorbable Implants; D000368:Aged; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D006801:Humans; D007558:Italy; D008131:London; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015607:Stents; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome
Bioresorbable vascular scaffold; Enhanced stent visualization system; Optical coherence tomography; Overlap; Stacked struts