Association between serum 25-hydroxyvitamin D and arterial stiffness in non-dialysis-dependent CKD.
Twenty-five-hydroxyvitamin D (25(OH)D) deficiency is common in chronic kidney disease (CKD) population. This study aimed to investigate the association between 25(OH)D and arterial stiffness in patients with non-dialysis-dependent CKD (CKD ND). Two hundred eighty-three patients aged ⩾18 years with CKD ND were divided into two groups: vitamin D deficient (25(OH)D<20 ng/ml) and vitamin D non-deficient (25(OH)D⩾20 ng/ml). Brachial-ankle pulse wave velocity (baPWV), a good marker for arterial stiffness, was calculated. The prevalence of vitamin D deficiency was 58.3% (165/283) and the mean concentration of 25(OH)D was 18±8 ng/ml. 25(OH)D inversely correlated with baPWV. Multiple linear regression analysis showed that vitamin D level was independently associated with baPWV in patients with CKD ND (β=-0.18, P<0.001). The model accounted for 45% (R(2)=0.45) of total variance of baPWV. Vitamin D deficiency is common in CKD ND, and a low 25(OH)D level is significantly associated with increased arterial stiffness.
Department of Nephrology, Ningbo No. 2 Hospital, Ningbo University School of Medicine, Ningbo, Zhejiang, China.
Q
Q
Luo
Department of Nephrology, Ningbo No. 2 Hospital, Ningbo University School of Medicine, Ningbo, Zhejiang, China.
L L
LL
Wang
Department of Nephrology, Ningbo No. 2 Hospital, Ningbo University School of Medicine, Ningbo, Zhejiang, China.
Y H
YH
Gao
D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D063177:Pulse Wave Analysis; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D059289:Vascular Stiffness; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*
D014807:Vitamin D; C104450:25-hydroxyvitamin D