Charting oxidized methylcytosines at base resolution.
DNA cytosine methylation is a key epigenetic mark that is required for normal mammalian development. Iterative oxidation of 5-methylcytosine (5mC) by the TET family of DNA dioxygenases generates three oxidized nucleotides: 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Recent advances in genomic mapping techniques have suggested that these oxidized cytosines not only function in the process of active reversal of 5mC but also may possess unique regulatory functions in the mammalian genome.
Howard Hughes Medical Institute, Boston, Massachusetts, USA.|Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.|Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, USA.
Hao
H
Wu
Howard Hughes Medical Institute, Boston, Massachusetts, USA.|Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.|Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, USA.
Yi
Y
Zhang
D044503:5-Methylcytosine / Q000378:metabolism* / Q000031:analogs & derivatives; D000818:Animals; D003596:Cytosine / Q000031:analogs & derivatives* / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D049308:Dioxygenases / Q000378:metabolism*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D008322:Mammals; D010084:Oxidation-Reduction
C560974:5-carboxylcytosine; C560973:5-formylcytosine; C011865:5-hydroxymethylcytosine; D044503:5-Methylcytosine; D003596:Cytosine; D004247:DNA; D049308:Dioxygenases