Copper-Catalyzed Direct Sulfoximination of Heteroaromatic N-Oxides by Dual C-H/N-H Dehydrogenative Cross-Coupling.
A dual C-H/N-H dehydrogenative coupling of quinoline-type N-oxides with sulfoximines that leads to N-(hetero)arylsulfoximines in high yields has been realized by using a catalytic amount of CuBr in air. The method does not require any additional ligand, base, reactivity modifier or oxidant and provides a practical route towards a series of sulfoximidoyl-functionalized quinolines and derivatives.
Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Hao
H
Yu
Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Carl Albrecht
CA
Dannenberg
Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Zhen
Z
Li
Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany. Carsten.Bolm@oc.RWTH-Aachen.de.
Carsten
http://orcid.org/0000-0001-9415-9917
C
Bolm
copper catalysis; dehydrogenative coupling; dual C−H/N−H activation; quinoline N-oxides; sulfoximines