Double-wire sternal closure technique in bovine animal models for total artificial heart implant.
In vivo preclinical testing of mechanical circulatory devices requires large animal models that provide reliable physiological and hemodynamic conditions by which to test the device and investigate design and development strategies. Large bovine species are commonly used for mechanical circulatory support device research. The animals used for chronic in vivo support require high-quality care and excellent surgical techniques as well as advanced methods of postoperative care. These techniques are constantly being updated and new methods are emerging.We report results of our double steel-wire closure technique in large bovine models used for Cleveland Clinic's continuous-flow total artificial heart development program. This is the first report of double-wire sternal fixation used in large bovine models.
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio - USA.
Jamshid H
JH
Karimov
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio - USA.
Gengo
G
Sunagawa
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio - USA.
Leonard A R
LA
Golding
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio - USA.|Department of Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, Miller Family Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio - USA.
Nader
N
Moazami
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio - USA.
Kiyotaka
K
Fukamachi
D000818:Animals; D002417:Cattle; D006354:Heart, Artificial; D023421:Models, Animal; D056346:Sternotomy; D013249:Sternum / Q000601:surgery*; D013536:Suture Techniques