Host evolution in Mastomys natalensis (Rodentia: Muridae): An integrative approach using geometric morphometrics and genetics.
The commensal rodent Mastomys natalensis is the natural reservoir of Lassa arenavirus (LASV), which causes hemorrhagic fever in West Africa. To study a possible effect of the virus on phenotypic and genotypic variation of its persistently infected host, we compared LASV-positive and non-infected wild-caught M. natalensis. The LASV effects on the phenotypic variation were explored using standard external morphometric measurements, geometric morphometric analyses of the cranial size and shape, and brain case volume. The genetic variability of M. natalensis specimens was assessed using 9 polymorphic microsatellite markers. Independent of sex and age, LASV-infected animals had smaller external body measurements, reproductive organs, skull size and brain case volume. Cranial shape differences between the 2 groups are represented by a lateral constriction of the entire skull. The genetic variability revealed consanguinity only among the LASV-positive rodents. We hypothesize that growth impairment may result in a selective disadvantage for LASV-infected M. natalensis, leading to a preferably commensal lifestyle in areas where the LAVS is endemic and, thereby, increasing the risk of LASV transmission to humans.
UMR 7205 Institute of Systematic, Evolution and Biodiversity (ISYEB), National Museum of Natural History CNRS, Sorbonne Universities, Paris, France.
Aude
A
Lalis
Institute of Evolutionary Sciences-Montpellier (ISEM), University of Montpellier, CNRS, IRD, EPHE, Montpellier, France.|Department of Archaeology, University of Aberdeen, Aberdeen, UK.
Allowen
A
Evin
Plateforme ANIMAGE-CREATIS, Faculty of Medicine Lyon-Est, Claude Bernard University Lyon 1, Lyon, France.
Marc
M
Janier
National Institute of Public Health Guinea, CHU Donka, Conakry, Guinea.
Lamine
L
Koivogui
UMR 7205 Institute of Systematic, Evolution and Biodiversity (ISYEB), National Museum of Natural History CNRS, Sorbonne Universities, Paris, France.
Christiane
C
Denys
D000818:Animals; D005075:Biological Evolution; D049628:Body Size; D001921:Brain / Q000033:anatomy & histology; D004197:Disease Reservoirs / Q000662:veterinary / Q000821:virology; D005260:Female; D051456:Gene Flow; D005835:Genitalia / Q000033:anatomy & histology; D016701:Guinea; D007835:Lassa Fever / Q000662:veterinary*; D007836:Lassa virus / Q000472:pathogenicity*; D008297:Male; D018895:Microsatellite Repeats; D051189:Murinae / Q000033:anatomy & histology / Q000235:genetics* / Q000821:virology*; D010641:Phenotype; D012376:Rodent Diseases / Q000821:virology; D012886:Skull / Q000033:anatomy & histology
genetic diversity; host evolution; inbreeding; skull shape variation