Orthognathic Surgery in a Patient with Multiple Sclerosis.
The aim of this paper was to report a case of orthognathic surgery successfully done in a patient with multiple sclerosis.



Multiple sclerosis (MS) is a chronic, progressive inflammatory disorder of the central nervous system affecting young adults, characterized by lymphocytic infiltration of the brain and spinal cord leading to demyelination and focal axonal damage. Clinically, MS patients present with reversible neurological dysfunction in the early stages, which progresses to irreversible neurological disability and deficit. Oral manifestations of MS include facial numbness or pain, neuralgias, facial paralysis, dysarthria and dysphagia. While dental treatment is not contraindicated in MS patients, it is, however, limited to preventive and supportive dental care.



A 23-year-old Saudi male patient with a diagnosis of MS since 2008 reported to the oral and maxillo-facial surgery (OMFS) department for correction of dentofacial deformity. The patient was under follow-up with the neurology department and was being treated with interferon beta-1a. Following consent from the neurologist and the patient, a Lefort 1 segmental osteotomy was done under general anesthesia. The patient was stable throughout the surgical procedure and during the postoperative period. The patient was discharged upon complete surgical recovery and no acute exacerbations of MS were reported during the perioperative period.



Based on our observations, orthognathic and maxillofacial surgical procedures can be safely carried out in patients with MS, provided a strict perioperative prophylactic regimen for stress reduction and prevention of acute attacks of MS is adhered to.



Due to the stressful nature of dental treatment and oral and maxillofacial surgical procedures, acute exacerbations of MS are very much likely. Hence, it is imperative that dental and oral surgical practitioners are aware of the manifestations of MS and are able to manage such patients with suitable treatment modifications.
Assistant Professor, Department of Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh, 11545, Saudi Arabia, Phone: +96653 2092386, e-mail: saalbazieomfs@gmail.com.
Saleh A
SA
Al-Bazie
D063169:Dentofacial Deformities / Q000601:surgery; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000503:physiopathology*; D056948:Orthognathic Surgical Procedures / Q000379:methods*; D019340:Osteotomy, Le Fort / Q000379:methods; D013515:Surgery, Oral / Q000379:methods; D055815:Young Adult
Multiple sclerosis; Orthognathic surgery; Dentofacial deformity; Interferon beta-1a; Lefort 1 osteotomy.