Bacteria in the CF Lung: Isolation Drives Diversity.
In-host pathogen evolution influences disease progression and chronicity, but forces that shape this remain poorly understood. In this issue of Cell Host & Microbe, Jorth et al. (2015) describe regional subpopulations of Pseudomonas aeruginosa in lungs from cyctic fibrosis patients and provide support for compartmentalization-driven evolution of this bacterium.
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland. Electronic address: pablo.manfredi@unibas.ch.
Pablo
P
Manfredi
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland. Electronic address: urs.jenal@unibas.ch.
Urs
U
Jenal
D003550:Cystic Fibrosis / Q000150:complications*; D014644:Genetic Variation; D006801:Humans; D008168:Lung / Q000382:microbiology*; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000145:classification* / Q000235:genetics*