In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites.
An assembly-induced retention effect for enhanced tumor photoacoustic (PA) imaging and therapeutics is described. A responsive small-molecule precursor is prepared that simultaneously self-assembles into nanofibers in tumor sites that exhibit an assembly-induced retention effect, which results in an improved PA imaging signal and enhanced therapeutic efficacy. This successful proof-of-concept study paves the way to develop novel supramolecular biomaterials for cancer diagnostics and therapeutics.
Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Zhongguancun, 100190, Beijing, China.
Di
D
Zhang
Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Zhongguancun, 100190, Beijing, China.
Guo-Bin
GB
Qi
Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Zhongguancun, 100190, Beijing, China.
Ying-Xi
YX
Zhao
Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Zhongguancun, 100190, Beijing, China.
Sheng-Lin
SL
Qiao
Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Zhongguancun, 100190, Beijing, China.
Chao
C
Yang
Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Zhongguancun, 100190, Beijing, China.
Hao
H
Wang
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D005047:Etoposide; D018093:Gelatinases / Q000737:chemistry; D051379:Mice; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers / Q000737:chemistry; D009368:Neoplasm Transplantation; D061088:Photoacoustic Techniques / Q000379:methods; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013696:Temperature; D013997:Time Factors; D041622:Tomography, Optical
D000970:Antineoplastic Agents; D011166:Porphyrins; C059051:purpurin 18; D005047:Etoposide; D018093:Gelatinases
chlorophyll; nanomaterials; photoacoustic imaging; supramolecular structures; tumor therapies