The use of primary and secondary doxazosin XL (8 mg) in the treatment of benign prostate hyperplasia: Is there a new approach in the event of alpha-blocker failure?
OBJECTIVE
Lower urinary tract symptoms (LUTS), which are related to benign prostate hyperplasia (BPH), are the most commonly encountered diseases in urological practice. In our study, we compared responses to (doxazosin mesylate extended release tablets) treatment.


METHODS
In our study, we included one hundred patients with LUTS who did not receive any medical treatment, and one hundred patients with LUTS who did not respond to alpha-blocker drugs other than doxazosin XL (8 mg). The inclusion criteria for the study were as follows: international prostate symptom score (IPSS)>7, prostate volume >20 cc, Q-max <15 mL/sn, lack of any previous pelvic or prostatic surgery, and /or urethral catheterization.


RESULTS
The mean age of the patients was 62.2±7.9 years. No statistically significant differences were detected between the groups with respect to age, prostate volume, and total prostate-specific antigen (PSA) levels. The duration of the follow-up period was calculated as 3-26 (mean 11) months. Significant differences were detected in post-voiding residual urine, IPSS, quality of life and Qmax between pre- and post-treatment values. Similar decreases in the IPSS scores, and increases in Qmax values were detected in both groups.


CONCLUSIONS
Doxazosin XL (8 mg) treatment was found to be efficient and reliable in primary patients and in patients with severe LUTS who did not respond to medical treatment. Trial of doxazosin XL (8 mg) therapy, before surgery in patients who respond inadequately to other alpha-blocker drugs is a rational approach.
Department of Urology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
Muhammet İhsan
Mİ
Karaman
Department of Urology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
Zülfü
Z
Sertkaya
Department of Urology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
Orhan
O
Koca
Department of Urology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
Mehmet
M
Akyüz
Department of Urology, Faculty of Medicine, Süleyman Demirel University, Turkey.
Mustafa
M
Güneş
Department of Urology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
Metin İshak
Mİ
Öztürk
Alpha-blocker; benign prostate hyperplasia; doxazosin