q-space MR imaging of gastric carcinoma ex vivo: Correlation with histopathologic findings.
The purpose of this study was to establish the feasibility of q-space imaging (QSI) as a method of assessing the depth of mural invasion, histologic grade, and the presence of lymph node metastasis in gastric carcinomas.



A 7.0 Tesla MR imaging system was used to investigate 20 gastric specimens containing a carcinoma. QSI was performed by using the following parameters: 50-60 mm × 25-30 mm field of view, 2-mm section thickness, 256 × 128 matrix, 10 b values in the 0-7163 s/mm(2) range, which corresponded to q values of 0-1026/cm, and motion-probing gradients perpendicular to the gastric wall. The MR images and the histopathologic findings were then compared.



The depth of tumor invasion of the gastric wall in all 20 carcinomas (100%) was established by using mean displacement, zero-displacement probability, and kurtosis maps. The QSI parameters were significantly correlated with the histologic grades of the gastric carcinomas (all P < 0.001). The QSI parameters made it possible to differentiate between metastatic and nonmetastatic lymph nodes (all P = 0.001).



Ex vivo QSI facilitates excellent diagnostics for evaluating gastric carcinomas in terms of mural invasion, histologic grade, and the presence of lymph node metastasis. Magn Reson Med 76:602-612, 2016. © 2015 Wiley Periodicals, Inc.
Department of Diagnostic Radiology and Nuclear Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Ichiro
I
Yamada
Department of Physiology, Keio University School of Medicine, Tokyo, Japan.|Central Institute for Experimental Animals, Kanagawa, Japan.
Keigo
K
Hikishima
Department of Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Naoyuki
N
Miyasaka
Department of Gastric Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Keiji
K
Kato
Department of Pathology, Tokyo Medical and Dental University, Tokyo, Japan.
Eisaku
E
Ito
Department of Gastric Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Kazuyuki
K
Kojima
Department of Esophageal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Tatsuyuki
T
Kawano
Department of Pathology, Tokyo Medical and Dental University, Tokyo, Japan.
Daisuke
D
Kobayashi
Department of Pathology, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshinobu
Y
Eishi
Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
Hideyuki
H
Okano
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D003627:Data Interpretation, Statistical; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*
MR imaging; diffusion-weighted imaging; gastric carcinoma; q-space imaging; stomach