[Clinical features and toxicity of tuberculosis treatment in patients with cancer].
OBJECTIVE
To assess the clinical and epidemiological characteristics of active tuberculosis in patients with malignancy and to assess the influence of TB treatment on cancer management at the National Institute of Neoplastic Diseases from 2008 to 2013.


METHODS
Observational study of TB cases diagnosed by positive sputum microscopy in patients with cancer. Clinical information, evolution, and pathologic information of neoplasia was reviewed.


RESULTS
76 cases of active tuberculosis after being diagnosed with cancer were found. The median age was 51.3 years. Median follow-up was 2.1 years. The most common cancers were acute lymphocytic leukemia (14.5%), for the hematologic cancers; and cancer of the cervix (14.5%), breast (10.5%), and gastric (7.9%) for non-hematological cancers. 27.6% of patients had recurrence of the tumor; TB diagnosis confounded the initial staging by 6.9% and was initially stated as cancer recurrence in 11.1% (breast and colon cancers). The diagnosis of tuberculosis delayed or influenced the dose reduction of the antineoplastic treatment in 11.1% of the cases (acute lymphocytic leukemia and non-Hodgkin lymphoma). 8.3% of patients had toxicity to the TB treatment.


CONCLUSIONS
Cancer patients may have active tuberculosis infection. The interference effect of diagnosis and treatment of tuberculosis on the assessment of cancer and cancer treatment in our series is minimal.
Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
Luis
L
Cuéllar
Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
Carlos A
CA
Castañeda
Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
Katerin
K
Rojas
Oncosalud/AUNA, Lima, Perú
Claudio
C
Flores
Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
Ketty
K
Dolores-Cerna
Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
Miluska
M
Castillo
Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
William
W
Vicente
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D012189:Retrospective Studies; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D055815:Young Adult
D000995:Antitubercular Agents