Coenzyme Q10 Suppresses TNF-α-Induced Inflammatory Reaction In Vitro and Attenuates Severity of Dermatitis in Mice.
Anti-oxidant coenzyme Q10 (Co-Q10) is commonly used in clinic. Recently, Co-Q10 was reported to antagonize TNF-α-induced inflammation and play a protective role in various inflammatory conditions. However, its role in dermatitis is unknown. Herein, RAW264.7 macrophage cell line was cultured with stimulation of TNF-α, and administration of Co-Q10 alleviated TNF-α-mediated inflammatory reaction in vitro. Furthermore, oxazolone-induced dermatitis mice model was established, and treatment of Co-Q10 markedly attenuated dermatitis phenotype in this mice model. Moreover, the protective role of Co-Q10 in vitro and in dermatitis was probably due to its repression on NF-κB signaling. Collectively, Co-Q10 may represent a potential molecular target for prevention and treatment of inflammatory skin diseases.
Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Weiwei
W
Li
Department of Pathology and Physiopathology, Shandong University Medical School, 44 Wenhuaxi Road, Jinan, Shandong, 250012, People's Republic of China.
Xiaojuan
X
Wu
Department of Gynaecology and Obstetrics, Jinan Central Hospital, Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Xiangling
X
Xu
Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Wenhan
W
Wang
Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Sijia
S
Song
Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Ke
K
Liang
Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, People's Republic of China.
Min
M
Yang
Department of Pathology and Physiopathology, Shandong University Medical School, 44 Wenhuaxi Road, Jinan, Shandong, 250012, People's Republic of China.
Linlin
L
Guo
Department of Orthopaedics, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, People's Republic of China. miraculously2008@163.com.
Yunpeng
Y
Zhao
Department of Pathology and Physiopathology, Shandong University Medical School, 44 Wenhuaxi Road, Jinan, Shandong, 250012, People's Republic of China. jane_stone2015@163.com.
Ruifeng
R
Li
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002460:Cell Line; D003877:Dermatitis, Contact / Q000188:drug therapy*; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism; D010081:Oxazolone; D012867:Skin / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000627:therapeutic use; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; C587672:IL1B protein, mouse; D053583:Interleukin-1beta; D015850:Interleukin-6; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D014451:Ubiquinone; D010081:Oxazolone; C024989:coenzyme Q10
NF-κB signaling; TNF-α; coenzyme Q10; dermatitis; inflammation