An Expanded Spectrum of High-Grade B-Cell Non-Hodgkin Lymphomas Involving the Cervicovaginal Region.
The uterine cervix and vaginal regions are infrequently infiltrated by lymphoma. Involvement of these topographic regions may constitute primary disease or more commonly represent a manifestation of systemic lymphomatous disease. Herein, we report an expanded spectrum of high-grade B-cell non-Hodgkin lymphomas comprising plasmablastic lymphoma (with and without plasmacytic differentiation), ALK-positive large B-cell lymphoma, and diffuse large B-cell lymphoma which involved the uterine cervix and/or vagina of 6 patients at initial diagnosis. These tumors clinically mimicked carcinoma and developed predominantly, but not exclusively, in the setting of human immunodeficiency virus infection.
National Health Laboratory Service (S.P., M.S.), Division of Anatomical Pathology Department of Medicine (V.P., A.B.L., M.P.), Division of Clinical Haematology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Gauteng Province Department of Molecular Medicine and Haematology (T.M.W.), Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.
Sugeshnee
S
Pather
Vinitha
V
Philip
Atul B
AB
Lakha
Tracey M
TM
Wiggill
Marie
M
Suleman
Moosa
M
Patel
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008875:Middle Aged; D060787:Neoplasm Grading; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor