Opsoclonus-myoclonus syndrome associated with multiple system atrophy.
Opsoclonus-myoclonus syndrome (OMS) is well known as a paraneoplastic syndrome or as a parainfectious neurologic complication. However, OMS associated with a neurodegenerative disorder has not been described previously. A 48-year-old woman had been diagnosed as multiple system atrophy-parkinsonian type (MSA-P) based on the findings of dopamine non-responsive parkinsonism with autonomic failure and typical findings on magnetic resonance imaging 5 years ago. She exhibited recurrent asynchronous and arrhythmic myoclonic movements of the upper limbs and abdomen with a very short duration, and involuntary eye movements, which were repetitive, rapid, random, multidirectional, conjugate saccades of irregular amplitude and frequency at rest. Based on hematological and radiological findings, the diagnosis was advanced MSA-P associated with OMS. As far as we are aware, there have not been any previous reports of such a case.
Department of Neurology, University of Yamanashi Hospital, 1110 Tamaho, Yamanashi, 409-3898 Japan.
Kazumasa
K
Shindo
Department of Neurology, University of Yamanashi Hospital, 1110 Tamaho, Yamanashi, 409-3898 Japan.
Akiko
A
Onohara
Department of Neurology, University of Yamanashi Hospital, 1110 Tamaho, Yamanashi, 409-3898 Japan.
Takanori
T
Hata
Department of Neurology, University of Yamanashi Hospital, 1110 Tamaho, Yamanashi, 409-3898 Japan.
Fumikazu
F
Kobayashi
Department of Neurology, University of Yamanashi Hospital, 1110 Tamaho, Yamanashi, 409-3898 Japan.
Kaori
K
Nagasaka
Department of Neurology, University of Yamanashi Hospital, 1110 Tamaho, Yamanashi, 409-3898 Japan.
Takamura
T
Nagasaka
Department of Neurology, University of Yamanashi Hospital, 1110 Tamaho, Yamanashi, 409-3898 Japan.
Yoshihisa
Y
Takiyama
Cerebellar vermis; Multiple system atrophy; Ocular symptom; Opsoclonus-myoclonus syndrome; Pontine reticular formation