Leptin and neuropeptide Y levels in newborns.
OBJECTIVE
Several studies have investigated leptin and neuropeptide Y (NPY) levels in children, but the information for newborns in the literature is limited. The purpose of this study was to determine leptin and NPY levels in 14- to 28-day-old newborns.


METHODS
This prospective study was performed in Atatürk University Medical Faculty Research Hospital Neonatal Clinic, Erzurum, Turkey between July and December, 2014. Sixty-two 14- to 28-day-old neonates, 26 female and 36 male, were included. Age, height, and body weight of the patients were recorded. Feeding status was also recorded. The newborns were divided into two groups--those receiving breastfeeding only and those receiving breastfeeding and formula. Plasma leptin levels were measured using enzyme amplified sensitivity immunoassay (EASIA).


RESULTS
The mean leptin level in 14- to 28-day-old female neonates was 4.25 ± 3.08 ng/mL, and the mean NPY level was 24.79 ± 9.87 ng/mL. The mean leptin level in 14- to 28-day male neonates was 3.49 ± 2.52 ng/mL, and the mean NPY level was 25.80 ± 9.58 ng/mL. No significant difference was determined between leptin (p=0.228) or NPY (p=0.144) in terms of feeding status. No significant difference was also observed between the sex in terms of leptin or NPY levels (leptin p=0.775 and NPY p=0.687).


CONCLUSIONS
There were no differences in terms of feeding status and sex in leptin and NPY levels in the neonatal period.
Avni
A
Kaya
Zerrin
Z
Orbak
İsmail
İ
Polat
Harun
H
Polat
Musa
M
Gümüşdere
D005260:Female; D006801:Humans; D007231:Infant, Newborn; D020738:Leptin / Q000097:blood*; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D011446:Prospective Studies
D020738:Leptin; D009478:Neuropeptide Y