Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide-Au nanomaterials.
A sensitive electrochemical sensor has been fabricated to detect Isoniazid (INZ) using reduced graphene oxide (RGO) and Au nanocomposites (RGO-Au). RGO-Au nanocomposites were synthesized by a solution-based approach of chemical co-reduction of Au(III) and graphene oxide (GO), and were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, and Fourier transform infrared (FT-IR). The Au nanoparticles separate the RGO sheets in the precipitate and prevent RGO sheets from aggregation upon π-π stacking interactions. RGO-Au nanocomposites were used to modify the glassy carbon electrode (GCE). The electrochemical properties of RGO-Au/GCE were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), and the RGO-Au/GCE exhibited remarkably strong electrocatalytic activities towards INZ. Under the optimized conditions, there was linear relationships between the peak currents and the concentrations in the range of 1.0×10(-7)M to 1.0×10(-3)M for INZ, with the limit of detection (LOD) (based on S/N=3) of 1.0×10(-8)M for INZ.
Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China. Electronic address: guozhuochina@syuct.edu.cn.
Zhuo
Z
Guo
Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.
Ze-Yu
ZY
Wang
Shagang School of Iron and Steel, Soochow University, Suzhou 215021, China. Electronic address: hhwang@suda.edu.cn.
Hui-Hua
HH
Wang
Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.
Guo-Qing
GQ
Huang
Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.
Meng-Meng
MM
Li
D015374:Biosensing Techniques / Q000295:instrumentation*; D002244:Carbon / Q000737:chemistry; D003217:Conductometry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005898:Glass / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D007538:Isoniazid / Q000032:analysis*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D008839:Microelectrodes; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010087:Oxides; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D010087:Oxides; D002244:Carbon; D006046:Gold; D006108:Graphite; D007538:Isoniazid
Au nanoparticles; Electrochemical sensor; Isoniazid; Reduced graphene oxide