How Sorbitan Monostearate Can Increase Drug-Loading Capacity of Lipid-Core Polymeric Nanocapsules.
Lipid-core polymeric nanocapsules are innovative devices that present distinguished characteristics due to the presence of sorbitan monostearate into the oily-core. This component acted as low-molecular-mass organic gelator for the oil (medium chain triglycerides). The organogel-structured core influenced the polymeric wall characteristics disfavoring the formation of more stable polymer crystallites. This probably occurred due to interpenetration of these pseudo-phases. Sorbitan monostearate dispersed in the oily-core was also able to interact by non-covalent bonding with the drugs increasing the drug loading capacity more than 40 times compared to conventional nanocapsules. We demonstrated that the drug-models quercetin and quercetin pentaacetate stabilized the organogel network probably due to interactions of the drug molecules with the sorbitan monostearate headgroups by hydrogen bonding.
Fernanda S
FS
Poletto
Catiúscia P
CP
De Oliveira
Heberton
H
Wender
Dorothée
D
Regent
Bruna
B
Donida
Sérgio R
SR
Teixeira
Sílvia S
SS
Guterres
Bartira
B
Rossi-Bergmann
Adriana R
AR
Pohlmann
D006601:Hexoses / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry*; D010316:Particle Size; D011794:Quercetin / Q000737:chemistry; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
D006601:Hexoses; D008055:Lipids; D053769:Nanocapsules; D011794:Quercetin; C009298:sorbitan monostearate