Hydrolytically degradable hyperbranched PEG-polyester adhesive with low swelling and robust mechanical properties.
Photocrosslinkable and water soluble hyperbranched PEG-polyester polymers (HPEGDA) have been developed as robust degradable adhesives. The HPEGDA polymers have been synthesized from controlled homopolymerization of poly(ethylene glycol) diacrylate (PEGDA700 ) via in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). By introducing a high initiator-to-monomer ratio, the obtained HPEGDA polymer is composed of extremely short carbon-carbon backbones interconnected together by the long PEG chains as well as pendent photocrosslinkable acrylate moieties. Due to the extremely short C-C backbone, the long PEG chains can therefore be seen as the main chain, thus, HPEGDA polymers behave more like polyester which is a category of polymers that contain the ester functional group in their main chain. Photo-cured HPEGDA can be readily adhered to tissue forming a patch with robust mechanical and adhesive strengths. The degradation profile by hydrolysis of polyester blocks as well as a significantly low swelling ratio of HPEGDA gels in an aqueous environment allow them to have great potential for sealing and repair of internal tissue. Furthermore, HPEGDA gels appear to have minor significant cytotoxicity in vitro. These unique properties indicate that the reported HPEGDA polymers are well poised for the development of adhesive tissue engineering matrixes, wound dressings, and sealants.
The Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin, 4, Dublin, Ireland.
Hong
H
Zhang
The Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin, 4, Dublin, Ireland.
Tianyu
T
Zhao
The Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin, 4, Dublin, Ireland.
Patrick
P
Duffy
The Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin, 4, Dublin, Ireland.
Yixiao
Y
Dong
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, 4, Dublin, Ireland.
Aisling Ní
AN
Annaidh
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, 4, Dublin, Ireland.|School of Mechanical & Materials Engineering, University College Dublin, 4, Dublin, Ireland.
Eoin
E
O'Cearbhaill
The Charles Institute of Dermatology, School of Medicine and Medical Science, University College Dublin, 4, Dublin, Ireland.|School of Materials Science and Engineering, Tianjin University, Tianjin, 30072, China.
Wenxin
W
Wang
D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D051379:Mice; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012212:Rheology; D014014:Tissue Adhesives / Q000737:chemistry*; D023822:Tissue Engineering
D001672:Biocompatible Materials; D020100:Hydrogels; D011091:Polyesters; D014014:Tissue Adhesives; C437167:poly(ethylene glycol)diacrylate; D011092:Polyethylene Glycols
PEG-based polymers; UV curing; degradable; interbranching; low swelling