Effects of Intravenous Patient-Controlled Sufentanil Analgesia and Music Therapy on Pain and Hemodynamics After Surgery for Lung Cancer: A Randomized Parallel Study.
OBJECTIVE
Postoperative pain is caused by surgical injury and trauma; is stressful to patients; and includes a series of physiologic, psychological, and behavioral reactions. Effective postoperative analgesia helps improve postoperative pain, perioperative safety, and hospital discharge rates. This study aimed to observe the influence of postoperative intravenous sufentanil patient-controlled analgesia combined with music therapy versus sufentanil alone on hemodynamics and analgesia in patients with lung cancer.


METHODS
This was a randomized parallel study performed in 60 patients in American Society of Anesthesiologists class I or II undergoing lung cancer resection at the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University. Patients were randomly assigned to a music therapy (MT) group and a control (C) group. The MT group underwent preoperative and postoperative music intervention while the C group did not. Both groups received intravenous patient-controlled sufentanil analgesia. The primary outcome was the visual analogue scale (VAS) score at 24 hours after surgery. The secondary outcomes included hemodynamic changes (systolic blood pressure, diastolic blood pressure, heart rate), changes on the Self-Rating Anxiety Scale (SAS), total consumption of sufentanil, number of uses, sedation, and adverse effects. The postoperative sufentanil dose and analgesia frequency were recorded.


RESULTS
Compared with the C group, the MT group had significantly lower VAS score, systolic and diastolic blood pressure, heart rate, and SAS score within 24 hours after surgery (p < 0.01). In addition, postoperative analgesia frequency and sufentanil dose were reduced in the MT group (p < 0.01).


CONCLUSIONS
Combined music therapy and sufentanil improves intravenous patient-controlled analgesia effects compared with sufentanil alone after lung cancer surgery. Lower doses of sufentanil could be administered to more effectively improve patients' cardiovascular parameters.
1 Department of Anesthesiology, Xiangya Hospital, Central South University , Changsha, Hunan Province, China .|2 Department of Critical Care Medicine, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, Hunan Province, China .
Yichun
Y
Wang
3 Department of Hospice and Palliative Care, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, Hunan Province, China .
Haoke
H
Tang
1 Department of Anesthesiology, Xiangya Hospital, Central South University , Changsha, Hunan Province, China .
Qulian
Q
Guo
4 Department of Anesthesiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, Hunan Province, China .
Jingshi
J
Liu
3 Department of Hospice and Palliative Care, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, Hunan Province, China .
Xiaohong
X
Liu
5 Department of Pathology, Qinghai People's Hospital, Xining, Qinghai Province, China .
Junming
J
Luo
4 Department of Anesthesiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, Hunan Province, China .
Wenqian
W
Yang
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009147:Music Therapy / Q000706:statistics & numerical data*; D010149:Postoperative Pain / Q000628:therapy*; D017409:Sufentanil / Q000008:administration & dosage* / Q000627:therapeutic use*
D017409:Sufentanil