Investigation of the role of VEGF gene polymorphisms in the risk of osteosarcoma.
We conducted a case-control study in a Chinese population, and assessed whether the VEGF -634G/C, +936C/T, and +1612G/A polymorphisms could affect the risk of osteosarcoma and its association with environmental factors. A total of 180 consecutive osteosarcoma patients and 360 controls were included in our study. The genotypes of VEGF -634G/C, +936C/T, and +1612G/A were determined by the polymerase chain reaction-restriction fragment length polymorphism assay. Conditional logistic regression analyses showed that subjects carrying the GG genotype and the G allele of VEGF -634G/C were significantly associated with increased risk of osteosarcoma compared to those with the CC genotype; the ORs (95%CIs) were 2.28 (1.31-3.96) and 1.51 (1.16-1.97) for the GG genotype and G allele, respectively. We found that the GG genotype of VEGF -634G/C was associated with a significantly increased risk of osteosarcoma in patients of either gender with younger age and a family history of cancer. In summary, this study found that the VEGF -634G/C gene polymorphism was associated with an increased risk of osteosarcoma.
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
G
G
Zhang
Department of Pediatric Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
R
R
Bai
Department of Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
T
T
Zhang
Department of Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
H
H
Zhang
Department of Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
S Z
SZ
Wen
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China jiangdm12@126.com.
D M
DM
Jiang
D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A