Chief cell-predominant gastric polyps: a series of 12 cases with literature review.
OBJECTIVE
Rare gastric lesions composed of a combined proliferation of chief and oxyntic cells have been variably called adenocarcinoma of fundic gland type and oxyntic gland polyp/adenoma. Herein, we present a series of cases that show a morphological spectrum of chief and oxyntic cell proliferations.


RESULTS
Routine and consultation cases were collated from five institutions. Information regarding site, size, endoscopic appearance, clinical history and medication use, when available, was accrued, as was the histological features and immunoprofiles. A total of 12 cases were collated. Age ranged from 39 to 81 years. All the lesions were located in the fundus; seven of eight were polypoid lesions endoscopically. Lesions were primarily solitary, averaged 4.6 mm in diameter (largest 9 mm) and comprised >50% chief cells. The predominant architectural pattern was of anastomosing and solid and clustered glands or a mixture of these patterns. Lesions were limited mainly to the mucosa, although two showed submucosal involvement. None had known metastatic disease.


CONCLUSIONS
This series included lesions that were previously described as gastric adenocarcinoma of fundic gland type and oxyntic gland polyp/adenoma. They are located exclusively in the fundus and composed predominantly of chief cells with low-grade cytology and appear to show a morphological continuum.
Pathwest, QEII Medical Centre, Perth, Western Australia, Australia.|Western Diagnostic Pathology, Perth, Western Australia, Australia.
Karen
K
Chan
Envoi Pathology, Brisbane, Queensland, Australia.
Ian S
IS
Brown
St John of God Pathology, Perth, Western Australia, Australia.
Trevor
T
Kyle
Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Gregory Y
GY
Lauwers
Pathwest, QEII Medical Centre, Perth, Western Australia, Australia.|School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia.
Marian Priyanthi
MP
Kumarasinghe
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D019872:Chief Cells, Gastric / Q000473:pathology*; D005260:Female; D005748:Gastric Fundus / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor
chief cells; fundic gland; gastric polyp; oxyntic gland; stomach neoplasm