Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats.
Aluminum (Al) is the most abundant metal in the earth's crust. Al accumulates in erythrocyte and causes toxicity on erythrocyte membrane. The dysfunction of erythrocyte membrane is a potential risk to hypertension. The high Al content in plasma was associated with hypertension. To investigate the effect of AlCl3 on blood pressure and the function of erythrocyte membrane, the rats were intragastrically exposed to 0, 64(1/20 LD50), 128(1/10 LD50), and 256(1/5 LD50) mg/kg body weight AlCl3 in double distilled water for 120 days, respectively. Then, we determined the systolic and mean arterial blood pressures of rats, the osmotic fragility, the percentage of membrane proteins, the activities of Na(+)/K(+)-ATPase, Mg(2+)-ATPase, Ca(2+)-ATPase, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-pX), and malondialdehyde (MDA) content of the erythrocyte membrane in this experiment. The results showed that AlCl3 elevated the systolic and mean arterial blood pressure of rats, increased the osmotic fragility, decreased the percentage of membrane protein, inhibited the activities of Na(+)/K(+)-ATPase, Mg(2+)-ATPase, Ca(2+)-ATPase, CAT, SOD and GSH-pX, and increased the MDA content of erythrocyte membrane. These results indicate that AlCl3 may induce hypertension by disturbing the function of erythrocyte membrane.
College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Qiuyue
Q
Zhang
College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Zheng
Z
Cao
College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Xudong
X
Sun
College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Cuicui
C
Zuang
College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Wanyue
W
Huang
College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. liyanfei@neau.edu.cn.
Yanfei
Y
Li
D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D002712:Chlorides / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride
Activities of ATPase; AlCl3; Erythrocyte membrane function; Hypertension; Male rats; Membrane protein