Myeloid-derived suppressor cells in B cell malignancies.
Tumor cells use several mechanisms such as soluble immune modulators or suppressive immune cells to evade from anti-tumor responses. Immunomodulatory cytokines, such as transforming growth factor-β, interleukin (IL)-10, and IL-35, soluble factors, such as adenosine, immunosuppressive cells, such as regulatory T cells, NKT cells and myeloid-derived suppressor cells (MDSCs), are the main orchestra leaders involved in immune suppression in cancer by which tumor cells can freely expand without immune cell-mediated interference. Among them, MDSCs have attracted much attention as they represent a heterogenous population derived from myeloid progenitors that are expanded in tumor condition and can also shift toward other myeloid cells, such as macrophages and dendritic cells, after tumor clearing. MDSCs exert their immunosuppressive effects through various immune and non-immune mechanisms which make them as potent tumor-promoting cells. Although, there are several studies regarding the immunobiology of MDSCs in different solid tumors, little is known about the precise characteristics of these cells in hematological malignancies, particularly B cell malignancies. In this review, we tried to clarify the precise role of MDSCs in B cell-derived malignancies.
Infectious Diseases Research Center and Laboratory Science Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Yaghoub
Y
Yazdani
Department of Immunology and Microbiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Mousa
M
Mohammadnia-Afrouzi
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.|Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mehdi
M
Yousefi
Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Enayat
E
Anvari
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Ghasem
G
Ghalamfarsa
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Hadi
H
Hasannia
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Sanam
S
Sadreddini
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. f-jadidin@razi.tums.ac.ir.
Farhad
F
Jadidi-Niaragh
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology*
B cell malignancies; Immune suppression; Leukemia; Lymphoma; Multiple myeloma; Myeloid-derived suppressor cells