Synthesis of 3-Substituted 2-Aminochromones via Sn(IV)-Promoted Annulation of Ynamides with 2-Methoxyaroyl Chlorides.
A Sn(IV)-promoted annulation reaction of ynamides is described for the efficient synthesis of 3-substituted 2-aminochromones under mild conditions. This novel method allows for a concomitant construction of C-C and C-O bonds between ynamides and 2-methoxyaroyl chlorides by a tandem Friedel-Crafts acylation/oxo-Michael addition/elimination strategy.
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
Hongxu
H
Liu
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
Yanyan
Y
Yang
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
Shen
S
Wang
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
Jie
J
Wu
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
Xiao-Na
XN
Wang
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
Junbiao
J
Chang