Protein-Protein Interaction Network could reveal the relationship between the breast and colon cancer.
OBJECTIVE
This study is aimed to elicit the possible correlation between breast and colon cancer from molecular prospective by analyzing and comparing pathway-based biomarkers.


BACKGROUND
Breast and colon cancer are known to be frequent causes of morbidity and mortality in men and women around the world. There is some evidence that while the incident of breast cancer in young women is high, it is reported lower in the aged women. In fact, aged women are more prone to colorectal cancer than older men. . In addition, many studies showed that several biomarkers are common among these malignancies.


METHODS
The genes were retrieved and compared from KEGG database and WikiPathway, and subsequently, protein-protein interaction (PPI) network was constructed and analyzed using Cytoscape v:3.2.1 software and related algorithms.


RESULTS
More than forty common genes were identified among these malignancies; however, by pathways comparison, twenty genes are related to both breast and colon cancer. Centrality and cluster screening identified hub genes, including SMAD2, SMAD3, (SMAD4, MYC), JUN, BAD, TP53. These seven genes are enriched in regulation of transforming growth factor beta receptor signaling pathway, positive regulation of Rac protein signal transduction, positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, and positive regulation of mitotic metaphase/anaphase transition respectively.


CONCLUSIONS
As there are numerous genes frequent between colorectal cancer and breast cancer, there may be a common molecular origin for these malignancies occurrences. It seems that breast cancer in females interferes with the rate of colorectal cancer incidence.
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mona
M
Zamanian-Azodi
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mostafa
M
Rezaei-Tavirani
Department of Cell and Molecular Biology, Faculty of Science, University of Tehran, Tehran, Iran.
Sara
S
Rahmati-Rad
Cancer Research Center, Department of Medical Physics, Semnan University of Medical Science, Semnan, Iran.
Hadi
H
Hasanzadeh
Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Majid
M
Rezaei Tavirani
Department of Medical Genetics, Tehran University of Medical Sciences, International Campus (TUMS- IC), Tehran, Iran.
Samaneh Sadat
SS
Seyyedi