Translation in the mammalian oocyte in space and time.
A hallmark of oocyte development in mammals is the dependence on the translation and utilization of stored RNA and proteins rather than the de novo transcription of genes in order to sustain meiotic progression and early embryo development. In the absence of transcription, the completion of meiosis and early embryo development in mammals relies significantly on maternally synthesized RNAs. Post-transcriptional control of gene expression at the translational level has emerged as an important cellular function in normal development. Therefore, the regulation of gene expression in oocytes is controlled almost exclusively at the level of mRNA and protein stabilization and protein synthesis. This current review is focused on the recently emerged findings on RNA distribution related to the temporal and spatial translational control of the meiotic progression of the mammalian oocyte.
Institute of Animal Physiology and Genetics, ASCR, Rumburska 89, 277 21, Libechov, Czech Republic. susor@iapg.cas.cz.
Andrej
A
Susor
Institute of Animal Physiology and Genetics, ASCR, Rumburska 89, 277 21, Libechov, Czech Republic.
Denisa
D
Jansova
Institute of Animal Physiology and Genetics, ASCR, Rumburska 89, 277 21, Libechov, Czech Republic.|CEITEC-Veterinary Research Institute, Hudcova 296/70, 621 00, Brno, Czech Republic.
Martin
M
Anger
Institute of Animal Physiology and Genetics, ASCR, Rumburska 89, 277 21, Libechov, Czech Republic.
Michal
M
Kubelka
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008540:Meiosis; D009865:Oocytes / Q000166:cytology* / Q000378:metabolism*; D009866:Oogenesis; D014176:Protein Biosynthesis; D012313:RNA / Q000032:analysis / Q000235:genetics; D059467:Transcriptome
D012313:RNA
Meiosis; Oocyte; RNA; RNP; Translation