Effects of Combined Spinal-Epidural Analgesia during Labor on Postpartum Electrophysiological Function of Maternal Pelvic Floor Muscle: A Randomized Controlled Trial.
OBJECTIVE
Combined spinal-epidural analgesia (CSEA) is sometimes used for difficult births, but whether it contributes to postpartum pelvic muscle disorder is unclear. This randomized controlled trial examined whether CSEA given during labor affects the electrophysiological index of postpartum pelvic floor muscle function.


METHODS
A consecutive sample of primiparous women who delivered vaginally at term were randomly assigned to a CSEA group (n = 143) and control group (n = 142) between June 2013 and June 2014. All were assessed 6-8 weeks later for electrophysiological function of pelvic floor muscle.


RESULTS
The two groups were similar in the degree of muscle strength, muscle fatigue, and pelvic dynamic pressure of pelvic floor muscle. The CSEA and control groups showed similar proportions of women with normal muscle strength (score ≥4) in type I pelvic fibers (23.1% vs. 14.1%, P = 0.051) and type II pelvic fibers (28.0% vs. 24.6%, P = 0.524). The groups also contained similar proportions of women who showed no fatigue in type I fibers (54.5% vs. 48.6%, P = 0.315) or type II fibers (88.8% vs. 87.3%, P = 0.699). Similarly low proportions of women in the CSEA group and control group showed normal pelvic dynamic pressure (11.2% vs. 7.7%, P = 0.321). However, women in the CSEA group spent significantly less time in labor than those in the control group (7.25 vs. 9.52 h, P <0.001).


CONCLUSIONS
CSEA did not affect the risk of postpartum pelvic muscle disorder in this cohort of primiparous women who gave birth vaginally. A significant shorter duration of labour was observed in the CSEA-group.


BACKGROUND
ClinicalTrials.gov NCT02334150.
Anesthesia Department, Maternal and Child Health Hospital of Nanning City, Nanning 530011, China.
Ji-Juan
JJ
Xing
Pain Management Department, First Affiliated Hospital of Peking University, Beijing 100034, China.
Xiu-Fen
XF
Liu
Obstetrics and Gynecology Department, Maternal and Child Health Hospital of Nandan County, Hechi 547200, China.
Xiao-Ming
XM
Xiong
Pain Management Department, First Affiliated Hospital of Peking University, Beijing 100034, China.
Li
L
Huang
Anesthesia Department, Maternal and Child Health Hospital of Nanning City, Nanning 530011, China.
Cheng-Yi
CY
Lao
Maternity Care Department, Maternal and Child Health Hospital of Nanning City, Nanning 530011, China.
Mei
M
Yang
Maternity Care Department, Maternal and Child Health Hospital of Nanning City, Nanning 530011, China.
Shan
S
Gao
Anesthesia Department, Maternal and Child Health Hospital of Nanning City, Nanning 530011, China.
Qiong-Yan
QY
Huang
Anesthesia Department, Maternal and Child Health Hospital of Nanning City, Nanning 530011, China.
Wei
W
Yang
Anesthesia Department, Maternal and Child Health Hospital of Nanning City, Nanning 530011, China.
Yun-Feng
YF
Zhu
Child Care Department, Maternal and Child Health Hospital of Nanning City, Nanning 530011, China.
Di-Hua
DH
Zhang
D000328:Adult; D015360:Analgesia, Epidural / Q000379:methods*; D016362:Analgesia, Obstetrical / Q000379:methods*; D000701:Analgesics, Opioid; D016022:Case-Control Studies; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D018763:Muscle Fatigue; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D010298:Parity; D017773:Pelvic Floor / Q000502:physiology*; D049590:Postpartum Period; D011247:Pregnancy; D017409:Sufentanil
D000701:Analgesics, Opioid; D017409:Sufentanil