Photoinduced Copper-Catalyzed Regioselective Synthesis of Indoles: Three-Component Coupling of Arylamines, Terminal Alkynes, and Quinones.
The first successful example of a visible-light-induced copper-catalyzed process for C-H annulation of arylamines with terminal alkynes and benzoquinone is described. This three-component reaction allows use of a variety of commercial terminal alkynes as coupling partners for the one-step regioselective synthesis of functionalized indoles. Moreover, the current process represents a sustainable and atom-economical approach for the preparation of complex indoles from easily accessible starting materials under visible-light irradiation, without the need for expensive metals and harsh reaction conditions.
Department of Chemistry, National Tsing Hua University, Hsinchu (Taiwan, R. O. C.).
Arunachalam
A
Sagadevan
Department of Chemistry, National Tsing Hua University, Hsinchu (Taiwan, R. O. C.).
Ayyakkannu
A
Ragupathi
Department of Chemistry, National Tsing Hua University, Hsinchu (Taiwan, R. O. C.). kchwang@mx.nthu.edu.tw.
Kuo Chu
KC
Hwang
annulations; copper; heterocycles; photochemistry; radicals