Nanostructured materials detect epidermal growth factor receptor, neuron specific enolase and carcinoembryonic antigen.
New nanostructured materials based on thin films of Cu and Ni deposited on textile material (veil), as well as gold nanostructured microspheres were used for the design of new stochastic sensors. The stochastic sensors were able to detect simultaneously a panel of biomarkers comprising epidermal growth factor receptor, neuron specific enolase, and carcinoembryonic antigen from whole blood samples with high reliabilities - recovery tests higher than 97.00%, with a RSD (%) lower than 0.1%. The stochastic sensors had shown high sensitivities and low determination levels for the detection of the proposed panel of biomarkers making early detection of lung cancer possible by fast screening of whole blood.
Laboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei St., Bucharest, 060021, Romania. ralucavanstaden@gmail.com.
Raluca-Ioana
RI
Stefan-van Staden
Ionela Raluca
IR
Comnea-Stancu
Carmen Cristina
CC
Surdu-Bob
Marius
M
Badulescu
D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000097:blood* / Q000378:metabolism; D066246:ErbB Receptors / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D010751:Phosphopyruvate Hydratase / Q000097:blood* / Q000378:metabolism; D015203:Reproducibility of Results
D015415:Biomarkers; D002272:Carcinoembryonic Antigen; C512478:EGFR protein, human; D066246:ErbB Receptors; D010751:Phosphopyruvate Hydratase