Autophagy in light-induced retinal damage.
Vision is reliant upon converting photon signals to electrical information which is interpreted by the brain and therefore allowing us to receive information about our surroundings. However, when exposed to excessive light, photoreceptors and other types of cells in the retina can undergo light-induced cell death, termed light-induced retinal damage. In this review, we summarize our current knowledge regarding molecular events in the retina after excessive light exposure and mechanisms of light-induced retinal damage. We also introduce works which investigate potential roles of autophagy, an essential cellular mechanism required for maintaining homeostasis under stress conditions, in the illuminated retina and animal models of light-induced retinal damage.
Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China; Clinical Research Institute of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Yu
Y
Chen
Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Lindsay
L
Perusek
Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA; Departments of Pharmacology, Case Western Reserve University, Cleveland, OH, 44106, USA. Electronic address: aam19@case.edu.
Akiko
A
Maeda
D000818:Animals; D001343:Autophagy / Q000528:radiation effects*; D008027:Light / Q000009:adverse effects*; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000473:pathology*; D012160:Retina / Q000528:radiation effects*; D012164:Retinal Diseases / Q000209:etiology / Q000473:pathology*
ATG7; All-trans-retinal; Beclin1; Light-induced retinal damage; Park2; Visual cycle