IκB kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway (Review).
Recent studies have shown that IκB kinase α (IKKα) plays an important role in human skin cancer and acts as a major regulator for keratinocyte terminal differentiation and proliferation. IKKα deficiency or mutation is associated with human tumor development; thus, overexpression of IKKα could prevent tumor progression. However, findings suggest that IKKα is equally essential for many other epithelial-derived tumors. In the present study, we discussed the role of IKKα as a tumor suppressor in IKKα-mediated epithelial‑derived tumors and its activation pathway, which is different from the traditional NF-κB pathway. The present study provides theoretical basis for understanding the molecular mechanisms involved in IKKα-related tumors.
Department of Radiation Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Yuxin
Y
Xie
Department of Anesthesiology, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China.
Keqi
K
Xie
State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Qiheng
Q
Gou
Department of Radiation Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Nianyong
N
Chen
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006258:Head and Neck Neoplasms / Q000201:enzymology; D006801:Humans; D051550:I-kappa B Kinase / Q000502:physiology*; D015603:Keratinocytes / Q000201:enzymology; D008175:Lung Neoplasms / Q000201:enzymology; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000201:enzymology*; D025521:Tumor Suppressor Proteins / Q000502:physiology*
D025521:Tumor Suppressor Proteins; C496559:CHUK protein, human; D051550:I-kappa B Kinase