Circadian clocks, obesity and cardiometabolic function.
Life on earth is governed by the continuous 24-h cycle of light and dark. Organisms have adapted to this environment with clear diurnal rhythms in their physiology and metabolism, enabling them to anticipate predictable environmental fluctuations over the day and to optimize the timing of relevant biological processes to this cycle. These rhythms are regulated by molecular circadian clocks, and current evidence suggests that interactions between the central and peripheral molecular clocks are important in metabolic and vascular functions. Disrupting this process through mutations in the core clock genes or by interfering with the environmental zeitgebers that entrain the clock appear to modulate the function of cells and tissues, leading to an increased risk for cardiometabolic disease.
Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine Clarendon Way, University of Leeds, Leeds, UK.
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Scott
D002318:Cardiovascular Diseases / Q000209:etiology*; D021081:Chronobiology Disorders / Q000150:complications*; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D008029:Lighting / Q000009:adverse effects; D008659:Metabolic Diseases / Q000209:etiology*; D009765:Obesity / Q000209:etiology*
cardiovascular; circadian; clock; diabetes; diurnal; environmental; genetic; obesity