Association between sleep quality and inflammatory complement components in collegiate males.
BACKGROUND
An accumulating amount of evidence has linked humoral mediators of inflammation with sleep measures. Nevertheless, important details of this association, in particular the role of the complement components in the context of chronic sleep attributes, have remained largely uncharacterized.


METHODS
Fifty university students (age, 23.3 ± 3.8 years; BMI, 23.7 ± 2.9 kg/m(2)) completed the study. Four dichotomized sleep measures assessed by the Pittsburgh Sleep Quality Index (PSQI) were used in association analysis using binary logistic regression with complement component 3, 4, and complement factor I (CFI). The sleep measures were defined as sleep quality (good sleep/poor sleep; PSQI ≤5/PSQI >5), bedtime (early/late; before 00:00 h/after 0:00 h), sleep duration (short/normal ≤6 h/>6 h), and sleep onset latency (normal/disturbed; 0-1 score/2-3 score on the PSQI component of sleep latency).


RESULTS
The complement component 4 was associated with sleep quality (unadjusted, OR = 1.025, p < 0.05; adjusted for age, OR = 1.025, p < 0.05; adjusted for BMI, OR = 1.027, p < 0.05) and sleep duration (unadjusted, OR = 1.041, p < 0.01; adjusted for age, OR = 1.041, p < 0.01; adjusted for BMI, OR = 1.046, p < 0.01). CFI was associated with bedtime (unadjusted, OR = 0.737, p < 0.01; adjusted for age, OR = 0.717, p < 0.01; adjusted for BMI, OR = 0.677, p < 0.01) and with sleep duration (unadjusted, OR = 0.796, p < 0.05; adjusted for age, OR = 0.796, p < 0.05).


CONCLUSIONS
The findings indicate the importance of the role of complement components in the dynamics of sleep. Therefore, sleep should be assessed in conditions where complement components are affected.
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, Maulana Mohammad Ali Jauhar Marg, New Delhi, 110025, India.
Md Dilshad
MD
Manzar
Department of Biochemistry, Institute of Home Economics, University of Delhi, New Delhi, India.
Mohammad Muntafa
MM
Rajput
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, Maulana Mohammad Ali Jauhar Marg, New Delhi, 110025, India.
Wassilatul
W
Zannat
Department of Physiotherapy, Fatima College of Health Sciences, Al Mafraq, Abu Dhabi City, United Arab Emirates.
Unaise Abdul
UA
Hameed
Department of Physiotherapy, Fatima College of Health Sciences, Al Mafraq, Abu Dhabi City, United Arab Emirates.|Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, 22110, Irbid, Jordan.
Muhammed Deeb
MD
Al-Jarrah
, 652 Dufferin St., Toronto, ON, Canada.
David Warren
DW
Spence
Somnogen Canada Inc, Toronto, ON, Canada.
Seithikurippu R
SR
Pandi-Perumal
Department of Medicine, College of Medicine, The University Sleep Disorders Centre, Riyadh, Saudi Arabia.|The Strategic Technologies Program of the National Plan for Sciences and Technology and Innovation in the Kingdom of Saudi Arabia, Riyadh, Saudi Arabia.
Ahmed S
AS
BaHammam
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, Maulana Mohammad Ali Jauhar Marg, New Delhi, 110025, India. hussainmejaz@gmail.com.
M Ejaz
ME
Hussain
D015992:Body Mass Index; D003181:Complement C4 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008297:Male; D012016:Reference Values; D012890:Sleep / Q000276:immunology*; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000276:immunology; D055815:Young Adult
D003181:Complement C4
Complement component; Inflammation; Pittsburgh Sleep Quality Index; Sleep; Sleep duration; Sleep quality