Comparison of Serum Autoantibodies to Desmogleins I, III in Patients with Oral Lichen Planus and Healthy Controls.
OBJECTIVE
Lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesion but its etiology is not completely understood. Desmogleins I and III are the main desmosomal transmembrane proteins. These proteins have been identified as the autoantigen of the autoimmune disease. The aim of this study was evaluation of serum autoantibodies against desmogleins Ι, ΙΙΙ in oral lichen planus .


METHODS
We attempted to determine the etiology of this disease with evaluation of these serum factors. Thirty-five patients with oral lichen planus and 35 healthy controls were recruited and tested for serum autoantibodies against desmogleins Ι, ΙΙΙ and indirect immunofluorescence also performed. Data were analyzed by statistical-analytical methods (Independent sample t -test) with using the SPSS.15 software.


RESULTS
Serum autoantibody against desmoglein Ι had no significant difference in the two groups ( P =0.31 ) but significant increase in serum autoantibody to desmoglein ΙΙΙ was found in patients with oral lichen planus ( P =0.00) .


CONCLUSIONS
It seems that autoantibody against desmoglein III has a significant role in the pathogenesis of oral lichen planus.
Dept. of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Narges
N
Gholizadeh
Dept. of Pediatric Hematology and Oncology, Hamadan University of Medical Science, Hamadan, Iran.
Hossein
H
Khoini Poorfar
Dept. of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz.
Ali
A
TaghaviZenouz
Dept. of Pediatric Dentistry, Tabriz University of Medical Science, Tabriz, Iran.
Masoumeh
M
Vatandoost
Dept. of Oral and Maxillofacial Medicine, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Masoumeh
M
Mehdipour
III -Serum Level; Lichen Planus- Desmogleins I