Association of single nucleotide polymorphism rs3792876 in SLC22A4 gene with autoimmune thyroid disease in a Chinese Han population.
BACKGROUND
The autoimmune thyroid diseases (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), are caused by interactions between susceptibility genes and environmental triggers. Single nucleotide polymorphisms (SNPs) of Solute carrier family 22, member 4 (SLC22A4) have been shown to be associated with several autoimmune diseases, including Crohn's disease (CD) and rheumatoid arthritis (RA). The aim of this study is to investigate whether SNP rs3792876 in the SLC22A4 gene is associated with GD, HT and AITD in a Chinese Han population.


METHODS
In this study, we collected specimens from 553 Chinese Han individuals of 92 AITD pedigrees in 10 cities in Liaoning province, China (80 GD pedigrees, 478 members; 12 HT pedigrees, 75 members). SNP rs3792876 was genotyped using the TaqMan allelic discrimination assay. Hardy-Weinberg Equilibrium tests were performed among founders of the pedigrees using Haploview software. Family-based association tests performed using FBAT software.


RESULTS
No deviation from Hardy-Weinberg equilibrium was observed (p > 0.05). There were not significant association between the SLC22A4 gene polymorphism (rs3792876) and GD, HT and AITD was found.


CONCLUSIONS
These results suggest a lack of association between the SLC22A4 gene polymorphism rs3792876 and susceptibility to GD, HT and AITD in a Chinese Han population.
Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. houxin83@163.com.|Department of Geriatric Endocrinology and Metabolism, The First Hospital of China medical University, Shenyang, China. houxin83@163.com.
Xin
X
Hou
Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. jinyuanmao@hotmail.com.
Jinyuan
J
Mao
Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Key Laboratory of Endocrine Diseases, Liaoning Province, 110001, Shenyang, China. liyushu@hotmail.com.|Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. liyushu@hotmail.com.
Yushu
Y
Li
Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. jiajia_li@hotmail.com.
Jia
J
Li
Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Key Laboratory of Endocrine Diseases, Liaoning Province, 110001, Shenyang, China. wei1127@hotmail.com.|Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. wei1127@hotmail.com.
Weiwei
W
Wang
Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. 842602504@qq.com.
Chenling
C
Fan
Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. whong8976@163.com.
Hong
H
Wang
Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. happyriver2005@sina.com.
Hongmei
H
Zhang
Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Key Laboratory of Endocrine Diseases, Liaoning Province, 110001, Shenyang, China. shanzhongyan@medmail.com.cn.|Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. shanzhongyan@medmail.com.cn.
Zhongyan
Z
Shan
Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Key Laboratory of Endocrine Diseases, Liaoning Province, 110001, Shenyang, China. twp@vip.163.com.|Key Laboratory of Endocrine Diseases, Liaoning Province, Shenyang, China. twp@vip.163.com.
Weiping
W
Teng
D044466:Asian People / Q000235:genetics*; D001327:Autoimmune Diseases / Q000208:ethnology / Q000235:genetics*; D060005:Genotyping Techniques; D006801:Humans; D027701:Organic Cation Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D027981:Symporters; D013959:Thyroid Diseases / Q000208:ethnology / Q000235:genetics*
D027701:Organic Cation Transport Proteins; C109807:SLC22A4 protein, human; D027981:Symporters