Study on Dendrobium officinale O-Acetyl-glucomannan (Dendronan). 7. Improving Effects on Colonic Health of Mice.
This research was aimed to study the effect of Dendrobium officinale polysaccharide (Dendronan) on colonic health. Mice were fed Dendronan at doses of 40, 80, and 160 mg/kg body weight for 0, 10, 20, and 30 days, respectively. Results showed that Dendronan, which has a special structure formed by mannose and glucose, rich in O-acetyl groups, exhibited improving effects on colonic and fecal parameters of Balb/c mice. After Dendronan feeding, the content of short-chain fatty acids (SCFAs), colon length and index, and fecal moisture were increased, whereas colonic pH was decreased and defecation time was shortened. All of these changes were significantly different between polysaccharide-treated groups and the control group (p < 0.05). These findings suggested that an adequate intake of Dendronan is beneficial to the process of fermentation and regulation of colonic microenvironment, thus playing a role in the maintenance of colonic health.
State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang 330047, People's Republic of China.
Guan-ya
GY
Zhang
State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang 330047, People's Republic of China.
Shao-ping
SP
Nie
State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang 330047, People's Republic of China.
Xiao-jun
XJ
Huang
State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang 330047, People's Republic of China.
Jie-lun
JL
Hu
State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang 330047, People's Republic of China.|Guelph Food Research Centre, Agriculture and Agri-Food Canada , 93 Stone Road West, Guelph, Ontario N1G 5C9, Canada.
Steve W
SW
Cui
State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang 330047, People's Republic of China.
Ming-yong
MY
Xie
Glyn O. Phillips Hydrocolloid Research Centre, Glyndŵr University , Wrexham LL11 2AW, United Kingdom.
Glyn O
GO
Phillips
D000818:Animals; D003106:Colon / Q000378:metabolism*; D003672:Defecation / Q000502:physiology; D031667:Dendrobium / Q000737:chemistry*; D004040:Dietary Carbohydrates / Q000032:analysis; D005227:Fatty Acids / Q000032:analysis; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005285:Fermentation; D008297:Male; D008351:Mannans / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D011134:Polysaccharides / Q000032:analysis
D004040:Dietary Carbohydrates; D005227:Fatty Acids; D005232:Fatty Acids, Volatile; D008351:Mannans; D011134:Polysaccharides; C000602098:dendronan; C022901:(1-6)-alpha-glucomannan
Dendrobium officinale O-acetyl-glucomannan; colonic health; defecation time; fecal moisture; short-chain fatty acids