Oxytocin use during Caesarean sections in Denmark - are we getting the dose right?
BACKGROUND
In Denmark, an iv bolus of 10 IU oxytocin was traditionally given after delivery to prevent atony during caesarean sections. Randomized controlled trials have shown that lower iv bolus doses have same efficacy with fewer side effects and many countries now recommend a 5 IU maximum dose. The aims of this study were to investigate whether patients referred for allergy testing after oxytocin exposure had dose-related side effects to oxytocin rather than true allergic reactions and to investigate whether updated international recommendations on lower bolus doses had been implemented in practice.


METHODS
Medical notes of patients tested with oxytocin as part of investigations in the Danish Anaesthesia Allergy Centre from May 2004 to January 2014 were reviewed retrospectively. A telephone survey of on-duty obstetricians at all Danish obstetric departments was performed and most recent online recommendations from the Danish societies of obstetrics and anaesthesia about the use of oxytocin were identified.


RESULTS
In total 30 women were tested with oxytocin as part of investigations. None were allergic to oxytocin but 19 had symptoms consistent with dose-related side effects on iv provocation. The telephone survey revealed that iv doses of 10 IU oxytocin were still used and recommendations on the websites were not updated.


CONCLUSIONS
Too high oxytocin doses are still used in Denmark leading to dose-related side effects mimicking allergic reactions. Coordination between obstetricians and anaesthesiologists on producing common updated guidelines on the administration of oxytocin and dissemination of this information to obstetric and anaesthetic departments in Denmark is needed.
Department of Anaesthesia, Aalborg University Hospital, Aalborg, Denmark.
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Kjaer
Danish Anaesthesia Allergy Centre, Allergy Clinic, Gentofte Hospital, Hellerup, Denmark.
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Krøigaard
Danish Anaesthesia Allergy Centre, Allergy Clinic, Gentofte Hospital, Hellerup, Denmark.
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LH
Garvey
D000328:Adult; D002585:Cesarean Section / Q000379:methods*; D015331:Cohort Studies; D003718:Denmark; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D010120:Oxytocics / Q000008:administration & dosage* / Q000009:adverse effects; D010121:Oxytocin / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D012189:Retrospective Studies; D013689:Telephone; D053802:Tryptases / Q000032:analysis; D055815:Young Adult
D010120:Oxytocics; D010121:Oxytocin; D053802:Tryptases