Association between Th17-related cytokines and risk of non-small cell lung cancer among patients with or without chronic obstructive pulmonary disease.
BACKGROUND
CD4 (+) T helper 17 (Th17) cells play critical roles in inflammation and tumor development. The involvement of Th17 cells in chronic obstructive pulmonary disease (COPD)-type inflammation-associated lung cancer has also been confirmed in animal models. However, to the authors' knowledge, it is unknown whether the role of Th17 cells is different in patients with lung cancer complicated with COPD compared with those without COPD. In the current study, the authors attempted to determine the association between the circulating levels of Th17-related cytokines and the clinical characteristics of non-small cell lung cancer (NSCLC) in patients with or without COPD.


METHODS
The authors designed a matched case-control study that included 70 patients with NSCLC with COPD, 148 patients with NSCLC without COPD, and 148 healthy controls. The data regarding the clinicopathological features of these participants were collected. Circulating levels of Th17-related cytokines, including interleukin (IL) 23 (IL-23), IL-17A, IL-17F, IL-22, and tumor necrosis factor-α, were measured.


RESULTS
The circulating levels of IL-23, IL-17A, IL-17F, IL-22, and tumor necrosis factor-α were found to be significantly higher in the patients with NSCLC compared with the healthy controls (P<.05). The elevated levels were found to be significantly associated with lung cancer risk (P<.05). However, no significant differences were found between patients with NSCLC with COPD and patients without COPD. It is interesting to note that, among patients with NSCLC without COPD, the levels of these cytokines were consistently higher among patients with stage I to stage IIIA disease compared with those with stage IIIB to stage IV disease (P<.05). In addition, the 5 Th17-related cytokines demonstrated pairwise correlations, with Spearman rank correlation coefficients of 0.646 to 0.888 (P<.05).


CONCLUSIONS
The results of the current study indicate a clear association between the Th17-related cytokine profile and the risk of NSCLC complicated by the presence or absence of COPD.
Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Chen
C
Liao
Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Zu-Bin
ZB
Yu
Department of Pathology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Gang
G
Meng
Department of Immunology, Third Military Medical University and Institute of Immunology, Chongqing, China.
Li
L
Wang
Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
Qing-Yun
QY
Liu
Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Liu-Tong
LT
Chen
Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Shuang-Shuang
SS
Feng
Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Hong-Bo
HB
Tu
Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
Ya-Fei
YF
Li
Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Li
L
Bai
D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000473:pathology; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D016207:Cytokines
CD4 + T helper 17 (Th17)-related cytokines; Luminex xMAP assays; case-control study; chronic obstructive pulmonary disease (COPD); non-small cell lung cancer