New Anti-inflammatory Norcembranoids from the Soft Coral Sinularia numerosa.
Two new norcembranoids, sinumerolide A (1) and its epimer, 7E-sinumerolide A (2), were isolated from the ethyl acetate extract of the soft coral Sinularia numerosa. The structures of compounds 1 and 2 were established using spectroscopic methods. In the in vitro anti-inflammatory effect test, norcembranoids 1 and 2 were found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein of lipopolysaccharide-stimulated RAW264.7 macrophage cells significantly.
Graduate Institute of Marine Biology, National Dong Hwa University.
Chen-Ting
CT
Yin
Zhi-Hong
ZH
Wen
Yu-Hsuan
YH
Lan
Yu-Chia
YC
Chang
Yang-Chang
YC
Wu
Ping-Jyun
PJ
Sung
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D008070:Lipopolysaccharides; C000608212:sinumerolide A; D052247:Nitric Oxide Synthase Type II