A thesaurus for a neural population code.
Information is carried in the brain by the joint spiking patterns of large groups of noisy, unreliable neurons. This noise limits the capacity of the neural code and determines how information can be transmitted and read-out. To accurately decode, the brain must overcome this noise and identify which patterns are semantically similar. We use models of network encoding noise to learn a thesaurus for populations of neurons in the vertebrate retina responding to artificial and natural videos, measuring the similarity between population responses to visual stimuli based on the information they carry. This thesaurus reveals that the code is organized in clusters of synonymous activity patterns that are similar in meaning but may differ considerably in their structure. This organization is highly reminiscent of the design of engineered codes. We suggest that the brain may use this structure and show how it allows accurate decoding of novel stimuli from novel spiking patterns.
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Elad
http://orcid.org/0000-0003-4834-5713
E
Ganmor
Department of Life Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Ronen
R
Segev
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Elad
E
Schneidman
D000200:Action Potentials; D000818:Animals; D008959:Models, Neurological; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology*; D014562:Caudata
entropy; information; metric; natural stimuli; neural code; neuroscience; noise; retina; salamander