The Aging Heart.
Aging results in progressive deteriorations in the structure and function of the heart and is a dominant risk factor for cardiovascular diseases, the leading cause of death in Western populations. Although the phenotypes of cardiac aging have been well characterized, the molecular mechanisms of cardiac aging are just beginning to be revealed. With the continuously growing elderly population, there is a great need for interventions in cardiac aging. This article will provide an overview of the phenotypic changes of cardiac aging, the molecular mechanisms underlying these changes, and will present some of the recent advances in the development of interventions to delay or reverse cardiac aging.
Department of Pathology, University of Washington, Seattle, Washington 98195.
Ying Ann
YA
Chiao
Department of Pathology, University of Washington, Seattle, Washington 98195.
Peter S
PS
Rabinovitch
D000375:Aging / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D031204:Caloric Restriction / Q000379:methods; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control; D005109:Extracellular Matrix / Q000502:physiology; D005260:Female; D005544:Forecasting; D006321:Heart / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008136:Longevity / Q000187:drug effects; D008297:Male; D051379:Mice; D035683:MicroRNAs / Q000187:drug effects; D028361:Mitochondrial Diseases / Q000503:physiopathology / Q000628:therapy; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D012084:Renin-Angiotensin System / Q000187:drug effects; D015398:Signal Transduction / Q000502:physiology; D020123:Sirolimus / Q000494:pharmacology; D033581:Stem Cell Transplantation / Q000379:methods
D035683:MicroRNAs; D018377:Neurotransmitter Agents; D002118:Calcium; D020123:Sirolimus