Gold Nanoparticles in Cancer Therapy: Efficacy, Biodistribution, and Toxicity.
Gold-based nanoparticles are utilized for cancer therapeutics as a system for drug delivery, or as a mediator for thermal therapy, whether ablation or hyperthermia. This review discusses how the design of the physicochemical properties of the different types of gold-based nanoparticles affects their treatment efficacy. The basic principles and mechanism at which it mediates heating and delivers drugs efficiently in vivo is also summarized. We will also review the in vivo preclinical data on the biodistribution, intratumoral distribution, cell internalization, and its associated toxicity. Lastly, an updated list of the clinical trials based on nanoparticles and future perspectives are provided.
Jun
J
Zhao
Patrick
P
Lee
Michael J
MJ
Wallace
Department of Interventional Radiology, Unit 1471, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. mmelancon@mdanderson.org.
Marites P
MP
Melancon
D055011:Ablation Techniques / Q000379:methods; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D006046:Gold; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy* / Q000601:surgery
D000970:Antineoplastic Agents; D004337:Drug Carriers; D006046:Gold