Combined effects of FTO rs9939609 and MC4R rs17782313 on elevated nocturnal blood pressure in the Chinese Han population.
OBJECTIVE
In this study we investigated the association of FTO rs9939609 and MC4R rs17782313 with elevated blood pressure in the Chinese Han population, and analysed the relationship between the rs9939609 and rs17782313 variants.


METHODS
We tested the rs9939609 and rs17782313 variants with the sequence-retrieval method.


RESULTS
The increase in odds ratios of the A allele of rs9939609 and the C allele of rs17782313 for nocturnal blood pressure were 1.37 and 1.69. The nocturnal blood pressure of participants simultaneously carrying the A and C alleles was significantly higher than the blood pressure of those carrying neither FTO nor MC4R risk alleles (p < 0.05), and that of the controls carrying only the A or C alleles (p < 0.05). No association between the FTO or MC4R genes with daytime hypertension was found in this Chinese population (p > 0.05).


CONCLUSIONS
Our data suggest that the rs9939609 and rs17782313 variants may be significantly associated with nocturnal but not daytime blood pressure levels and their combined effects were significant in this Chinese Han population.
Department of Endocrinology, the Third Hospital of Wuhan, Wuhan, China, 430060. syleilei2008@qq.com.
Yanlei
Y
Sun
Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, China, 430071.
Jiazhong
J
Sun
Department of Endocrinology, the Third Hospital of Wuhan, Wuhan, China, 430060.
Jun
J
Wu
Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, China, 430071.
Mei
M
Yang
D000328:Adult; D000368:Aged; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D044466:Asian People; D001794:Blood Pressure / Q000235:genetics* / Q000502:physiology*; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D012307:Risk Factors
C470072:MC4R protein, human; D044105:Receptor, Melanocortin, Type 4; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human