Increased serum soluble corin in dyslipidemia: A cross-sectional study.
BACKGROUND
Natriuretic peptides have been associated with dyslipidemia. As a physiological activator of natriuretic peptides, corin might also be associated with dyslipidemia. However, this association has not yet been studied in Chinese populations.


METHODS
Serum soluble corin and blood lipid profiles were determined for 2496 participants aged above 30y. A logistic regression model was applied to evaluate the association between serum soluble corin and dyslipidemia.


RESULTS
Serum soluble corin was significantly increased in participants with dyslipidemia in both men (P<0.001) and women (P<0.001). After controlling for the confounding factors, OR of dyslipidemia positively increased with increasing levels of serum soluble corin in men (P for trend=0.011) and women (P for trend=0.043). Participants with a high corin level were more likely to have dyslipidemia than those with a low corin level in men (OR, 95% CI: 1.45, 1.07-1.97) and women (OR, 95% CI: 1.33, 1.04-1.70).


CONCLUSIONS
Serum soluble corin was significantly and positively associated with dyslipidemia. Our findings suggested that serum soluble corin may be a marker or risk factor for dyslipidemia.
School of Nursing, Medical College of Soochow University, Suzhou, China.
Xiaolei
X
Wang
School of Nursing, Medical College of Soochow University, Suzhou, China.
Shi
S
Chen
Center for Disease Prevention and Control of Gusu District, Suzhou, China.
Qiu
Q
Zhang
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Yan
Y
Liu
School of Nursing, Medical College of Soochow University, Suzhou, China.
Lu
L
Liu
School of Nursing, Medical College of Soochow University, Suzhou, China; Department of Nursing, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: lhl8543@126.com.
Huiling
H
Li
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Hao
H
Peng
D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood* / Q000201:enzymology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012697:Serine Endopeptidases / Q000097:blood* / Q000737:chemistry*; D012995:Solubility
D008055:Lipids; C119812:CORIN protein, human; D012697:Serine Endopeptidases
Blood lipids; Chinese; Corin; Cross-sectional study; Dyslipidemia; Risk factor