-141C insertion/deletion polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in Chinese Han population: Evidence from an ethnic group-specific meta-analysis.
Accumulate evidence has implicated dopamine D2 receptor gene polymorphisms in the etiology of schizophrenia. A single nucleotide polymorphism, -141C insertion/deletion (Ins/Del) (rs1799732), in the promoter region of the dopamine D2 receptor gene has been linked to schizophrenia; however, the data are inconclusive. This study investigated whether the -141C polymorphism is associated with the risk of schizophrenia in different ethnic groups by performing a meta-analysis. A total of 24 case-control studies examining the association between -141C Ins/Del polymorphism and schizophrenia were identified according to established inclusion criteria. Significant association was revealed between -141C Ins/Del polymorphism and schizophrenia risk in dominant genetic model (Ins/Ins + Ins/Del versus Del/Del) (odds ratio = 0.33, 95% confidence interval = 0.14-0.81, z = 2.41, P = 0.02) in Chinese Han but not in Caucasian, Japanese or India populations. Our results indicate that -141C Ins/Del polymorphism might be a susceptibility factor for schizophrenia in Chinese Han population.
Clinical Pharmacology Base, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaofeng
X
Zhao
Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, China.
Yinglin
Y
Huang
Mental Health Center, Shantou University Medical College, Shantou, China.
Kaiyuan
K
Chen
Clinical Pharmacology Base, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Duolu
D
Li
Clinical Pharmacology Base, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chao
C
Han
Clinical Pharmacology Base, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Quancheng
Q
Kan
D044466:Asian People / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2
dopamine D2 receptor; meta-analysis; polymorphism; schizophrenia; −141C ins/del