Protective role of murine norovirus against Pseudomonas aeruginosa acute pneumonia.
The murine norovirus (MNV) is a recently discovered mouse pathogen, representing the most common contaminant in laboratory mouse colonies. Nevertheless, the effects of MNV infection on biomedical research are still unclear. We tested the hypothesis that MNV infection could alter immune response in mice with acute lung infection. Here we report that co-infection with MNV increases survival of mice with Pseudomonas aeruginosa acute lung injury and decreases in vivo production of pro-inflammatory cytokines. Our results suggest that MNV infection can deeply modify the parameters studied in conventional models of infection and lead to false conclusions in experimental models.
EA 7366: Pseudomonas aeruginosa Host-Pathogen Translational Research Group, UDSL, Université Lille Nord de France, 59045, Lille, France. Marion.thepaut@gmail.com.
Marion
M
Thépaut
EA 7366: Pseudomonas aeruginosa Host-Pathogen Translational Research Group, UDSL, Université Lille Nord de France, 59045, Lille, France. teddygrandjean6891@gmail.com.
Teddy
T
Grandjean
Laboratoire de virologie EA3610, Faculté de Médecine, CHRU, Université Lille 2, 59037, Lille, France. didier.hober@chru-lille.fr.
Didier
D
Hober
Laboratoire de virologie EA3610, Faculté de Médecine, CHRU, Université Lille 2, 59037, Lille, France. pierre-emmanuel.lobert@chru-lille.fr.
Pierre-Emmanuel
PE
Lobert
EA 7366: Pseudomonas aeruginosa Host-Pathogen Translational Research Group, UDSL, Université Lille Nord de France, 59045, Lille, France. perrine.bortolotti@gmail.com.
Perrine
P
Bortolotti
EA 7366: Pseudomonas aeruginosa Host-Pathogen Translational Research Group, UDSL, Université Lille Nord de France, 59045, Lille, France. karinefauremail@gmail.com.
Karine
K
Faure
EA 7366: Pseudomonas aeruginosa Host-Pathogen Translational Research Group, UDSL, Université Lille Nord de France, 59045, Lille, France. dessein.rodrigue@orange.fr.
Rodrigue
R
Dessein
EA 7366: Pseudomonas aeruginosa Host-Pathogen Translational Research Group, UDSL, Université Lille Nord de France, 59045, Lille, France. ekipnis@gmail.com.
Eric
E
Kipnis
EA 7366: Pseudomonas aeruginosa Host-Pathogen Translational Research Group, UDSL, Université Lille Nord de France, 59045, Lille, France. bguery@gmail.com.
Benoit
B
Guery
D000208:Acute Disease; D000818:Animals; D017250:Caliciviridae Infections / Q000276:immunology* / Q000821:virology; D060085:Coinfection / Q000276:immunology / Q000382:microbiology / Q000821:virology; D016207:Cytokines / Q000378:metabolism*; D056747:Immunomodulation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D029322:Norovirus / Q000502:physiology*; D011014:Pneumonia / Q000276:immunology* / Q000382:microbiology; D011552:Pseudomonas Infections / Q000276:immunology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000502:physiology; D012376:Rodent Diseases / Q000276:immunology* / Q000382:microbiology / Q000821:virology
D016207:Cytokines