Helicobacter pylori infection influences the severity of thrombocytopenia and its treatment response in chronic hepatitis B patients with compensatory cirrhosis: A multicenter, observational study.
The role of Helicobacter pylori (H. pylori) infection on thrombocytopenia in chronic hepatitis B (CHB) related compensatory cirrhotic patients is unknown. We conducted an observational study to determine whether H. pylori plays a role in these patients. A total of 255 patients from three centers in China were enrolled in the study. All patients received nucleoside analogs (NA) therapy and were screened for H. pylori infection. Patients were divided into three groups based on their H. pylori infection status and the therapy administered: patients without H. pylori infection who received NA therapy alone (N = 146); patients with H. pylori infection who received NA therapy alone (n = 48); and patients with H. pylori infection who received H. pylori eradication combined with NA therapy (N = 61). We observed that in CHB compensatory cirrhotic patients with H. pylori infection, the platelets count was significantly lower relative to uninfected patients (31 versus 60 × 10(9)/L, p < 0.01). During a 2-year follow-up, the elevation in platelet count was significantly higher in HBV/H. pylori co-infected patients who received the NA and H. pylori eradication treatment compared to the other two groups (p < 0.01). It suggested that H. pylori infection and eradication treatment combined with NA were independent risk factors associated with platelets response during treatment of thrombocytopenia in CHB compensatory cirrhosis (p < 0.01). In conclusion, H. pylori infection may associate with thrombocytopenia in CHB compensatory cirrhosis. H. pylori eradication combined with NA treatment may prove to be beneficial to CHB compensatory cirrhotic patients with thrombocytopenia who are infected with H. pylori.
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Xiao-Hui
XH
Zhang
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Yun
Y
He
b Department of Hematology , Beijing Hospital, Ministry of Health , Beijing , China .
Ru
R
Feng
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Lan-Ping
LP
Xu
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Qian
Q
Jiang
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Hao
H
Jiang
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Jin
J
Lu
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Hai-Xia
HX
Fu
b Department of Hematology , Beijing Hospital, Ministry of Health , Beijing , China .
Hui
H
Liu
c Department of Hematology , Beijing Tongren Hospital , Beijing , China , and.
Jing-Wen
JW
Wang
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Qian-Ming
QM
Wang
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Fei-Er
FE
Feng
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Xiao-Lu
XL
Zhu
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Lin-Lin
LL
Xu
d Peking University People's Hospital, Institute of Hepatic Diseases , Beijing , China.
Yang-Di
YD
Xie
d Peking University People's Hospital, Institute of Hepatic Diseases , Beijing , China.
Hui
H
Ma
d Peking University People's Hospital, Institute of Hepatic Diseases , Beijing , China.
Hao
H
Wang
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Kai-Yan
KY
Liu
a Peking University People's Hospital, Institute of Hematology , Beijing , China .
Xiao-Jun
XJ
Huang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D016480:Helicobacter pylori; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012307:Risk Factors; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers
Cirrhosis; Helicobacter pylori; hepatitis B; thrombocytopenia