[IN VIVO EVALUATION OF POLYCAPROLACTONE-HYDROXYAPATITE SCAFFOLD BIOCOMPATIBILITY].
Biocompatibility is one of the main and very important properties for scaffolds. The aim of the present study was to investigate cells population dynamics in vivo in the process of original polycaprolactone-hydroxyapatite scaffold colonization, as well as tissue reactions to the implantation to assess the biocompatibility of the matrix. It has been found that tissue reactive changes in white rats subside completely up to the 21st day after subcutaneous polycaprolactone-hydroxyapatite scaffold implantation. Matrix was actively colonized by connective tissue cells in the period from the 7th to the 21st day of the experiment. However, intensive scaffold vascularization started from the 14th day after implantation. These findings suggest a high degree of the polycaprolactone-hydroxyapatite scaffold biocompatiblilitye.
A N
AN
Ivanov
M N
MN
Kozadaev
N V
NV
Bogomolova
O V
OV
Matveeva
D M
DM
Puchinyan
I A
IA
Norkin
Yu E
YE
Sal'kovskii
G P
GP
Lyubun
D000818:Animals; D001672:Biocompatible Materials / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D003238:Connective Tissue / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D017886:Durapatite / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D005109:Extracellular Matrix / Q000187:drug effects / Q000473:pathology; D008297:Male; D008422:Materials Testing; D011091:Polyesters / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D016062:Porosity; D019919:Prosthesis Implantation; D051381:Rats; D013499:Surface Properties; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; D017886:Durapatite