Pre-chemotherapy values for left and right ventricular volumes and ejection fraction by gated tomographic radionuclide angiography using a cadmium-zinc-telluride detector gamma camera.
BACKGROUND
Estimation of left ventricular ejection fraction (LVEF) using equilibrium radionuclide angiography is an established method for assessment of left ventricular function. The purpose of this study was to establish normative data on left and right ventricular volumes and ejection fraction, using cadmium-zinc-telluride SPECT camera.


RESULTS
From routine assessments of left ventricular function in 1172 patients, we included 463 subjects (194 men and 269 women) without diabetes, previous potentially cardiotoxic chemotherapy, known cardiovascular or pulmonary disease. The lower limits defined as mean value minus two standard deviations for ventricular ejection fraction and end diastolic volume were LVEF (men: 50%, women: 50%), LEDV (men: 45 mL, women: 40 mL), RVEF (men: 29%, women: 28%), and REDV (men: 73 mL, women: 57 mL).There was a significant negative correlation between age and both left and right ventricular volumes in women (r = -0.4, P < .001) but only for right end systolic ventricular volume in men (r = -0.3, P = .001).


CONCLUSIONS
A set of reference values for cardiac evaluation prior to chemotherapy in cancer patients without other known cardiopulmonary disease is presented. There are age-related changes in cardiac dimensions with age depending on gender, although with only limited influence on LVEF or RVEF.
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Herlev, Denmark. Haarmark@dadlnet.dk.|Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, Building 60, Floor A, 2400, Copenhagen, Denmark. Haarmark@dadlnet.dk.
Christian
C
Haarmark
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Herlev, Denmark.
Christine
C
Haase
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Herlev, Denmark.
Maria Maj
MM
Jensen
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Herlev, Denmark.
Bo
B
Zerahn
D000970:Antineoplastic Agents / Q000008:administration & dosage; D016903:Drug Monitoring / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D015902:Gamma Cameras; D015637:Gated Blood-Pool Imaging / Q000295:instrumentation*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008875:Middle Aged; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009929:Organ Size; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology*; D016276:Ventricular Function / Q000502:physiology*
D000970:Antineoplastic Agents
CZT-SPECT camera; LVEF; chemotherapy; multigated acquisition scan; radionuclide angiography