Are capillary DBS applicable for therapeutic drug monitoring of common antipsychotics? A proof of concept.
OBJECTIVE
DBS sampling has been proposed as an alternative for venous blood collection in therapeutic drug monitoring (TDM) of antipsychotics. For implementation in routine practice, a comparison between capillary and venous blood concentrations is mandatory.


RESULTS
A DBS method for quantification of antipsychotics was clinically validated. First, whole blood therapeutic ranges were calculated using the blood:serum ratio. Calculation of DBS:blood ratios and Passing-Bablok regression analysis demonstrated that concentrations obtained by DBS analysis were highly comparable to those obtained by conventional whole blood analysis. Clinical interpretation of serum, whole blood and DBS concentrations were highly identical (sensitivity 91.6-97.6%).


CONCLUSIONS
This is the first clinical study demonstrating the value of DBS sampling in TDM of antipsychotics.
Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.|Laboratory for TDM & Toxicology, ZNA Stuivenberg, Lange Beeldekensstraat 267, B-2060 Antwerp, Belgium.
Lisbeth
L
Patteet
Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
Kristof E
KE
Maudens
Laboratory of Toxicology, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Christophe P
CP
Stove
Laboratory of Toxicology, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Willy E
WE
Lambert
Collaborative Antwerp Psychiatric Research Institute (CAPRI), Faculty of Medicine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.|Psychiatric Hospital Broeders Alexianen, Provinciesteenweg 408, B-2530 Boechout, Belgium.
Manuel
M
Morrens
Collaborative Antwerp Psychiatric Research Institute (CAPRI), Faculty of Medicine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.|Psychiatric Centre Sint-Norbertushuis, Stationstraat 22C, B-2570 Duffel, Belgium.
Bernard
B
Sabbe
Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.|Laboratory for TDM & Toxicology, ZNA Stuivenberg, Lange Beeldekensstraat 267, B-2060 Antwerp, Belgium.
Hugo
H
Neels
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000097:blood*; D059788:Dried Blood Spot Testing / Q000379:methods*; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D057230:Limit of Detection; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D044967:Serum; D055815:Young Adult
D014150:Antipsychotic Agents