Spiny Papules in an Immunosuppressed Child.
Trichodysplasia spinulosa is a rare folliculocentric polyomavirus infection observed in the setting of immunosuppression. We report a 7-year-old boy with pre-B-cell lymphoblastic leukemia who presented with folliculocentric spiny papules on the face. Histologic evaluation revealed hypertrophic bulbs, an expanded inner root sheath, and numerous brightly eosinophilic trichohyalin granules. We present this case to raise awareness of this rare but recognizable entity and to highlight the availability of appropriate diagnostic and therapeutic modalities.
Department of Dermatology, School of Medicine, University of Colorado, Aurora, Colorado.
Nicholas V
NV
Nguyen
Department of Dermatology, School of Medicine, University of Colorado, Aurora, Colorado.|Department of Pediatrics, School of Medicine, University of Colorado, Aurora, Colorado.
Arelis
A
Burgos
Department of Dermatology, School of Medicine, University of Colorado, Aurora, Colorado.|Department of Pediatrics, School of Medicine, University of Colorado, Aurora, Colorado.
Lori
L
Prok
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D006201:Hair Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D018859:Hair Follicle / Q000473:pathology / Q000821:virology*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use; D027601:Polyomavirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology*
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir