Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature.
The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.
Department of Applied Physics, Chalmers University of Technology, 41296 Göteborg, Sweden. adahlin@chalmers.se.
Juliane
J
Junesch
Gustav
G
Emilsson
Kunli
K
Xiong
Shailabh
S
Kumar
Takumi
T
Sannomiya
Hudson
H
Pace
Janos
J
Vörös
Sang-Hyun
SH
Oh
Marta
M
Bally
Andreas B
AB
Dahlin
D015374:Biosensing Techniques / Q000379:methods*; D008051:Lipid Bilayers / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D012822:Silicon Dioxide / Q000737:chemistry
D008051:Lipid Bilayers; D012822:Silicon Dioxide