Continuous intravenous antiarrhythmic agents in the intensive care unit: strategies for safe and effective use of amiodarone, lidocaine, and procainamide.
The development of cardiac arrhythmias in the intensive care unit is common and associated with poor prognoses and outcomes. Because of the complexity of patients admitted to the intensive care unit, the management of arrhythmias is often difficult and may require multiple therapeutic interventions. In order for clinicians to appropriately manage arrhythmias, a thorough understanding of all available therapies, including intravenous antiarrhythmic agents, is essential. Suitable antiarrhythmic agents for use in the critical care setting include amiodarone, lidocaine, and procainamide. While these agents can be effective in managing cardiac arrhythmias, they also possess significant disadvantages and require additional monitoring during use. Therapy with these agents is often complicated because of the presence of significant associated adverse effects, clinician unfamiliarity, variable dosing strategies, and the potential for drug-drug interactions. The purpose of this review is to discuss indications and strategies for safe and effective use of amiodarone, lidocaine, and procainamide.
Department of Pharmacy, Methodist University Hospital, Memphis, Tennessee (Drs Samarin and Oliphant); Department of Pharmacy, Temple University Hospital, Philadelphia, Pennsylvania (Dr Mohrien); Department of Clinical Pharmacy, University of Tennessee College of Pharmacy, Memphis, Tennessee (Dr Oliphant).
Michael J
MJ
Samarin
Kerry M
KM
Mohrien
Carrie S
CS
Oliphant
D000638:Amiodarone / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004347:Drug Interactions; D006801:Humans; D007262:Infusions, Intravenous; D007362:Intensive Care Units; D008012:Lidocaine / Q000627:therapeutic use*; D011342:Procainamide / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D008012:Lidocaine; D011342:Procainamide; D000638:Amiodarone