The association between myeloperoxidase 463G>A polymorphisms and risk of lung cancer in East-Asia population.
OBJECTIVE
The association between the myeloperoxidase (MPO) 463 G>A polymorphism and lung cancer risk remains controversial. We perform this meta-analysis to further evaluate the MPO 463G>A polymorphism and lung cancer susceptibility.


METHODS
We performed the systemic literature search in PubMed, EMBASE, WANFANG, and CNKI databases for molecular epidemiologic studies on the association of MPO 463G>A polymorphism and lung cancer susceptibility. The pooled odds ratio (OR) of MPO 463G>A polymorphism and lung cancer risk were calculated by random or fixed effect model.


RESULTS
Seven case-control studies including 1538 lung cancer patients in the case group and 1673 healthy controls in the control group were included in this study. MPO 463G>A polymorphism was not associated with lung cancer susceptibility under the condition of recessive genetic model (AA vs. GG+GA) (OR = 0.69, P > 0.05) and homozygous genetic model (AA vs. GG) (OR = 0.65, P > 0.05). However, we found significantly decreased risk of lung cancer under dominant genetic model (GA+AA vs. GG) (OR = 0.84, P < 0.05). And no publication bias was found in this meta-analysis for the three genetic models (P > 0.05).


CONCLUSIONS
This meta-analysis indicated that people with AA genetic type may have decreased lung cancer risk under dominant genetic model.
Xin
X
Hou
Yuhua
Y
Gao
Department of Oncology, The First Affiliated Hospital of Henan University, Henan, Kaifeng 475000, PR China.
Yongjian
Y
Duan
Zhiwei
Z
Wang
Lei
L
Shi
Jincheng
J
Ma
Xuanhu
X
Xie
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005202:Asia, Eastern / Q000453:epidemiology; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
D009195:Peroxidase