Azelaic Acid: Evidence-based Update on Mechanism of Action and Clinical Application.
Azelaic acid is a complex molecule with many diverse activities. The latter include anti-infective and anti-inflammatory action. The agent also inhibits follicular keratinization and epidermal melanogenesis. Due to the wide variety of biological activities, azelaic acid has been utilized as a management tool in a broad spectrum of disease states and cutaneous disorders. This paper reviews the clinical utility of azelaic acid, noting the quality of the evidence supporting each potential use.
Brian C
BC
Schulte
Wesley
W
Wu
Ted
T
Rosen
D000152:Acne Vulgaris / Q000188:drug therapy; D000506:Alopecia Areata / Q000188:drug therapy; D019557:Dermatitis, Perioral / Q000188:drug therapy; D003879:Dermatologic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003998:Dicarboxylic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D005148:Facial Dermatoses / Q000188:drug therapy*; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000188:drug therapy*; D008548:Melanosis / Q000188:drug therapy; D011565:Psoriasis / Q000188:drug therapy; D012393:Rosacea / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*
D003879:Dermatologic Agents; D003998:Dicarboxylic Acids; C010038:azelaic acid