The importance of prostate volume in prostate needle biopsy.
OBJECTIVE
Although ultrasound-guided prostate needle biopsy is the gold standard method in the diagnosis of prostate cancer, biopsy schemes and the number of repeated biopsies are still controversial today. It is known that the rate of prostate cancer decreases with increasing prostate volume. In this study, we evaluated the effects of prostate volume on cancer detection in our patient series.


METHODS
In our clinic, data for 992 patients who had gray zone PSA levels (2.5-10 ng/mL) and whose 10 core biopsies were taken between 2004 and 2010 were evaluated. Among them, 500 patients from whom 6 to 8 biopsies were taken, whose information was lacking and who had suspicious cancer findings after digital rectal examination were excluded from the study. Patient ages, free/total PSA levels (f/TPSA), PSA densities (PSAD), Gleason scores, and prostate volumes were compared between patients with (Group 1) or without biopsy-proven prostate cancer (Group 2). Student's t-test was used for statistical analysis.


RESULTS
According to biopsy findings, prostate cancer was detected in 74 patients while no cancer was detected in 418 patients. The mean age of Groups 1, and 2 were 65±8.6, and 64±8.1 years, respectively The mean prostate volume in Groups 1, and 2 were 45±23 cc, and 58±26 cc, respectively.


CONCLUSIONS
In line with the literature, the average prostate volume of the prostate cancer group was significantly lower. This supports the notion that cancer detection is more probable in small prostates than in high-volume prostates.
Clinic of Urology, Konya Numune Hospital, Konya, Turkey.
Ömer Gökhan
ÖG
Doluoğlu
Clinic of Urology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Çetin Volkan
ÇV
Öztekin
Clinic of Urology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Mehmet
M
Karabakan
Clinic of Urology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Alp Özgür
AÖ
Akdemir
Clinic of Urology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Mesut
M
Çetinkaya
Biopsy; prostate cancer; prostate volume