Polyoxygenated cyclohexene derivatives isolated from Dasymaschalon sootepense and their biological activities.
Six new naturally occurring polyoxygenated cyclohexene derivatives together with eight related known derivatives, two known alkaloids, and two known flavonoid derivatives were isolated from bioassay-guided fractionation of the ethyl acetate extract of the leaves and twigs of Dasymaschalon sootepense. The structure elucidation and determination of absolute configurations were established by various spectroscopic methods, X-ray diffraction techniques as well as comparison with the literature data. Several isolated compounds were evaluated for their cytotoxic, anti-HIV-1 RT and anti-inflammatory activities.
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand.
Sakchai
S
Hongthong
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand. Electronic address: chutima.kon@mahidol.ac.th.
Chutima
C
Kuhakarn
Mahidol University, Center of Excellence for Innovation in Chemistry (PERCH-CIC), Kanchanaburi Campus, Saiyok, Kanchanaburi, Thailand.
Thaworn
T
Jaipetch
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand.
Samran
S
Prabpai
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand.
Palangpon
P
Kongsaeree
Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand.
Pawinee
P
Piyachaturawat
Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand.
Surawat
S
Jariyawat
Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand.
Kanoknetr
K
Suksen
Department of Microbiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand.
Jitra
J
Limthongkul
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Ampai
A
Panthong
The Forest Herbarium National Park, Wildlife and Plant Conservation Department, Ministry of Natural Resources and Environment, Thailand.
Narong
N
Nuntasaen
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand.
Vichai
V
Reutrakul
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D053138:Cyclohexenes / Q000737:chemistry* / Q000302:isolation & purification; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000302:isolation & purification
D000470:Alkaloids; D019380:Anti-HIV Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D053138:Cyclohexenes; D018894:Reverse Transcriptase Inhibitors; C052568:cyclohexene
Anti-HIV-1 RT; Anti-inflammatory; Chlorohydrins; Cyclohexene oxides; Cytotoxicity; Dasymaschalon sootepense