Assessment of physical traits of rat offspring derived from mothers exposed to dioxin.
Negative effects of dioxin action are associated with limited abilities of their bio-degradation along with continuously increasing production and long-term bio-accumulation of those toxins in living organisms. Dioxins penetrate through placenta to fetus indicating indirect toxic effects on offspring of mothers exposed to the action of these toxins. During lactation a significant part of dioxins is excreted from organism with milk, which contributes to further accumulation of those compounds and multiple exceeding of maximal permissible dose of dioxins in newborns feeding with mother's milk. The aim of the study was to determine how a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to females 3 weeks before getting pregnant affects the parturition duration, labour delay, number and weight of offspring. The studies were performed on rat offspring deriving from primigravida females from the Buffalo strain, which 3 weeks before getting pregnant were administered with a single dose of TCDD. The obtained results revealed that labours in females exposed to dioxin effects were characterized by significant temporal range and their end occurred 3 weeks later compared to females from the control group, which gave birth within a very narrow temporal range ending within 2 days. Offspring obtained from females exposed to the TCDD action was smaller in number and was characterized by smaller rearing and smaller birth weight even after the first month of life; however weight gain in both groups was similar and it was twelve-fold increase.
Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Bartla 5 Street, 51-618 Wrocław, Poland. Electronic address: joanna.rosinczuk@umed.wroc.pl.
Joanna
J
Rosińczuk
Independent Laboratory of Clinical Neurotoxicology and Environmental Diagnostics, The Faculty of Health Science, Wroclaw Medical University, Bartla 5 Street, 51-618 Wrocław, Poland. Electronic address: ireneusz.calkosinski@umed.wroc.pl.
Ireneusz
I
Całkosiński
D000818:Animals; D001724:Birth Weight / Q000187:drug effects*; D005260:Female; D008098:Litter Size / Q000187:drug effects*; D018811:Maternal Exposure; D009929:Organ Size / Q000187:drug effects; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D015430:Weight Gain / Q000187:drug effects*
D000072317:Polychlorinated Dibenzodioxins
Dioxins; Offspring; Procreation; Reproduction; TCDD