CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women.
In this study, the relationship between CYP19 gene polymorphisms and breast cancer in Xinjiang Uigur women was investigated. A case-control study was designed to compare 112 Uigur breast cancer patients with 139 Uigur healthy controls. Individuals were genotyped for the CYP19 rs10046 polymorphism using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Accordingly, the relationship between the rs10046 polymorphism and the susceptibility of Xinjiang Uigur women to breast cancer was analyzed. Given that the allele at the rs10046 site varies between C and T within the CYP19 gene, the frequency distribution of the C and T allele in breast cancer subjects were 48.2 and 51.8% respectively, and 47.5 and 52.5% in control cases. Moreover, the frequency distribution of the TC, CC, and TT genotype were 26.8, 42.9, and 30.4% in breast cancer cases, but 18.0, 59.0, and 23.0% in control cases (P < 0.05). Risk factors within the Uigur population for breast cancer included an age ≥ 50 years old, a BMI ≥ 25 kg/m(2), and a parity ≥ 2. Conversely, an abortion and the CYP19 rs10046 TC genotype were protective factors. Menopause was another independent risk factor for breast cancer in Uigur women after the correction for age, BMI, age at first parity, pregnancy, and breastfeeding. In conclusion, breast cancer in Xinjiang Uigur women is closely connected with the age, BMI, parity, abortion, and CYP19 rs10046 polymorphisms. The TC genotype and an abortion can reduce the risk of the breast cancer disease in Uigur women.
The Xinjiang Uygur Autonomous Region, China.
L
L
Yang
The Xinjiang Uygur Autonomous Region, China.
X Y
XY
Wang
The Xinjiang Uygur Autonomous Region, China.
Y T
YT
Li
The Xinjiang Uygur Autonomous Region, China.
H L
HL
Wang
The Xinjiang Uygur Autonomous Region, China.
T
T
Wu
The Xinjiang Uygur Autonomous Region, China.
B
B
Wang
The Xinjiang Uygur Autonomous Region, China.
Q
Q
Zhao
The Xinjiang Uygur Autonomous Region, China.
D
D
Jinsihan
The Xinjiang Uygur Autonomous Region, China.
L P
LP
Zhu
D000328:Adult; D000368:Aged; D001141:Aromatase / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
D001141:Aromatase; C561410:CYP19A1 protein, human