Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations.
Using iterative lithiation-borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17% overall yield. The rapid build-up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis.
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS (UK).
Christopher A
CA
Brown
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS (UK). V.Aggarwal@bristol.ac.uk.
Varinder K
VK
Aggarwal
asymmetric synthesis; boron; iterative homologation; mycolactone; natural products