The Glasgow Prognostic Score. An useful tool to predict survival in patients with advanced esophageal squamous cell carcinoma.
OBJECTIVE
To evaluate the usefulness of the Glasgow Prognostic Score (GPS) in patients with esophageal carcinoma (EC).


METHODS
A total of 50 patients with EC were analyzed for GPS, nutritional and clinicopathologic parameters. Patients with CRP ≤ 1.0mg/L and albumin ≥ 3.5mg/L were considered as GPS = 0. Patients with only CRP increased or albumin decreased were classified as GPS = 1 and patients with CRP > 1.0mg/L and albumin < 3.5mg/L were considered as GPS = 2.


RESULTS
GPS of 0, 1 and 2 were observed in seven, 23 and 20 patients, respectively. A significant inverse relationship was observed between GPS scores and the survival rate. The survival rate was greatest in patients with GPS = 0 and significantly higher than those from patients with GPS = 1 and GPS = 2. Minimum 12-month survival was observed in 71% patients with GPS = 0 and in 30% patients with GPS = 1. None of the patients with GPS = 2 survived for 12 months. A significant relationship between CRP or albumin individually and the survival rate was observed. No significant relationship among nutritional, clinic pathological parameters and survival was found.


CONCLUSIONS
Glasgow Prognostic Score is an useful tool to predict survival in patients with esophageal carcinoma.
Botucatu Medical School, Universidade Estadual Paulista, BR.
Maria Aparecida Coelho de Arruda
MA
Henry
Medical School, UNESP, Botucatu, SP, BR.
Mauro Masson
MM
Lerco
Medical School, UNESP, Botucatu, SP, BR.
Walmar Kerche
WK
de Oliveira
Botucatu Medical School, UNESP, Botucatu, SP, BR.
Anderson Roberto
AR
Guerra
Department of Pathology, Botucatu Medical School, UNESP, Botucatu, SP, BR.
Maria Aparecida Marchesan
MA
Rodrigues
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000401:mortality* / Q000473:pathology; D004812:Epidemiologic Methods; D004938:Esophageal Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012016:Reference Values; D015203:Reproducibility of Results; D012709:Serum Albumin / Q000032:analysis*; D016019:Survival Analysis
D014408:Biomarkers, Tumor; D012709:Serum Albumin; D002097:C-Reactive Protein