Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation.
BACKGROUND
Traditionally, lipids used in parenteral nutrition (PN) are based on ω-6 fatty acid-rich vegetable oils, such as soybean oil, with potential adverse effects involving oxidative stress.


METHODS
We evaluated the antioxidant defense system in children, after hematopoietic stem cell transplantation (HSCT), who were randomized to use a lipid emulsion with fish oil or soybean oil. Blood samples at baseline, at 10 days, and at the end of the PN were taken to analyze plasma retinol, α-tocopherol, β-carotene, coenzyme Q9 and coenzyme Q10 levels, and catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPOX), and superoxide dismutase (SOD) levels in lysed erythrocytes.


RESULTS
An increase in plasma α-tocopherol levels in the group of patients receiving the fish oil-containing emulsion (FO) compared with the group receiving the soybean emulsion was observed at day 10 of PN. Concurrently, plasma α-tocopherol increased in the FO group and β-carotene decreased in both groups at day 10 compared with baseline levels, being more significant in the group receiving the FO emulsion.


CONCLUSIONS
FO-containing emulsions in PN could improve the antioxidant profile by increasing levels of α-tocopherol in children after HSCT who are at higher risk of suffering oxidative stress and metabolic disorders.
Department of Paediatrics, Reina Sofia University Hospital, Institute Maimónides of Biomedicine Investigation of Córdoba (IMIBIC), University of Córdoba, Avda Menéndez Pidal s/n, 14004 Córdoba, Spain. mabaenagomez@gmail.com.
María Auxiliadora
MA
Baena-Gómez
Department of Paediatrics, Reina Sofia University Hospital, Institute Maimónides of Biomedicine Investigation of Córdoba (IMIBIC), University of Córdoba, Avda Menéndez Pidal s/n, 14004 Córdoba, Spain. delatorremj@orange.es.
María José De La Torre
MJ
Aguilar
Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre of Biomedical Research, University of Granada, Avda del Conocimiento, 18071 Granada, Spain. mdmesa@ugr.es.
María Dolores
MD
Mesa
Department of Paediatrics, Reina Sofia University Hospital, Institute Maimónides of Biomedicine Investigation of Córdoba (IMIBIC), University of Córdoba, Avda Menéndez Pidal s/n, 14004 Córdoba, Spain. juanpereznavero@hotmail.com.
Juan Luis Pérez
JL
Navero
Department of Paediatrics, Reina Sofia University Hospital, Institute Maimónides of Biomedicine Investigation of Córdoba (IMIBIC), University of Córdoba, Avda Menéndez Pidal s/n, 14004 Córdoba, Spain. mercedes_gil_campos@yahoo.es.
Mercedes
M
Gil-Campos
D000293:Adolescent; D000367:Age Factors; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008297:Male; D018384:Oxidative Stress; D010288:Parenteral Nutrition / Q000379:methods*; D013024:Soybean Oil / Q000008:administration & dosage*; D013030:Spain; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation; D024502:alpha-Tocopherol / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D005217:Fat Emulsions, Intravenous; D005395:Fish Oils; D013024:Soybean Oil; D024502:alpha-Tocopherol
alpha-tocoferol; antioxidant status; children; fatty acids; fish oil; hematopoietic stem cell transplantation; lipid emulsions; oxidative stress; parenteral nutrition; soybean oil