Factors associated with diabetes mellitus prediction among pregnant Arab subjects with gestational diabetes.
There is scarcity of available information on the possible significant risk factors related to diabetes mellitus (DM) prediction among expectant Saudi mothers with gestational diabetes mellitus (GDM). The present study is the first to identify such risk factors in the Arab cohort. A total of 300 pregnant subjects (mean age 33.45 ± 6.5 years) were randomly selected from all the deliveries registered at the Obstetrics Department of King Fahad Medical City, Riyadh Saudi Arabia from April 2011 to March 2013. Demographic and baseline glycemic information were collected. A total of 7 highly significant and independent risk factors were identified: age, obesity, and family history of DM, GDM < 20 weeks, macrosomia, insulin therapy and recurrent GDM. Among these factors, subjects who had insulin therapy use are 5 times more likely to develop DMT2 (p-value 3.94 × 10(-14)) followed by recurrent GDM [odds-ratio 4.69 (Confidence Interval 2.34-4.84); P = 1.24 × 10(-13)). The identification of the risk factors mentioned with their respective predictive powers in the detection of DMT2 needs to be taken seriously in the post-partum assessment of Saudi pregnant patients at highest risk.
Faculty of Medicine, King Saud bin Abdul-Aziz University for Health Sciences Riyadh 22490, Saudi Arabia ; Specialized Diabetes and Endocrine Center, King Fahd Medical Riyadh 59046, Saudi Arabia ; Prince Mutable Chair for Biomarkers of Osteoporosis, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
Naji
N
Aljohani
Department of Maternal-Fetal Medicine, King Fahd Medical Riyadh 59046, Saudi Arabia.
Amal
A
Al Serehi
Women's Specialized Hospital, Riyadh, King Fahd Medical Riyadh 59046, Saudi Arabia.
Amjad M
AM
Ahmed
Specialized Diabetes and Endocrine Center, King Fahd Medical Riyadh 59046, Saudi Arabia.
Badr Aldin M
BA
Buhary
Faculty of Medicine, King Saud bin Abdul-Aziz University for Health Sciences Riyadh 22490, Saudi Arabia ; Specialized Diabetes and Endocrine Center, King Fahd Medical Riyadh 59046, Saudi Arabia.
Saad
S
Alzahrani
College of Sciences and Health Professions, King Saud Bin Abdul-Aziz University for Health Sciences Riyadh 22490, Saudi Arabia.
Eeman
E
At-Taras
Faculty of Medicine, King Saud bin Abdul-Aziz University for Health Sciences Riyadh 22490, Saudi Arabia.
Najla
N
Almujally
Faculty of Medicine, King Saud bin Abdul-Aziz University for Health Sciences Riyadh 22490, Saudi Arabia.
Maha
M
Alsharqi
Department of Medicine, King Abdul Aziz Medical Riyadh 11426, Saudi Arabia.
Mohammed
M
Alqahtani
Faculty of Medicine, King Saud bin Abdul-Aziz University for Health Sciences Riyadh 22490, Saudi Arabia ; Specialized Diabetes and Endocrine Center, King Fahd Medical Riyadh 59046, Saudi Arabia.
Mussa
M
Almalki
D000328:Adult; D018912:Arabs; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000208:ethnology*; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D016015:Logistic Models; D015999:Multivariate Analysis; D016017:Odds Ratio; D011247:Pregnancy; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D012529:Saudi Arabia / Q000453:epidemiology; D016896:Treatment Outcome
D007004:Hypoglycemic Agents; D007328:Insulin
GDM; Saudi; diabetes mellitus; pregnancy