The association between methylenetetrahydrofolate reductase 677C>T polymorphisms and breast cancer susceptibility: A meta-analysis based on Chinese Han population.
OBJECTIVE
The relationship between methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms and lung cancer susceptibility is controversial according to the case-control or cohort study. We perform this meta-analysis to evaluate the association between MTHFR 677C>T polymorphisms and lung cancer risk based on Chinese Han population.


METHODS
We searched the databases of Medline, PubMed, EMBASE, Wanfang, and CNIK to find the case-control or cohort study about the relationship between MTHFR 677C>T polymorphisms and lung cancer susceptibility. The genotype of CC, CT, and TT for the lung cancer patients and healthy controls were extracted and aggregated by meta-analysis method. The relationship between MTHFR 677C>T polymorphisms and lung cancer susceptibility was assessed by odds ratio (OR) and its 95% confidence interval (CI).


RESULTS
According to the inclusion and exclusion criteria, we finally included 14 case-control studies, with 2845 lung cancer patients and 3691 healthy controls in this meta-analysis. The pooled results showed the OR were 1.02 (95% CI: 0.93-1.13), 0.66 (95% CI: 0.60-0.73), and 1.25 (95% CI: 1.07-1.47) in recessive genetic model, dominant genetic model, and homozygous model, respectively.


CONCLUSIONS
Chinese Han people with TT/CT genotype of MTHFR gene may have increased the risk of developing breast cancer.
Department of Breast Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang 323000, China.
Jing
J
Hao
Pengfei
P
Zhao
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
D042965:Methylenetetrahydrofolate Reductase (NADPH2)