Hypervalent Iodine(III) in Direct Oxidative Amination of Arenes with Heteroaromatic Amines.
A novel, mild, and practical method of amination of simple nonfunctionalized arenes under metal free conditions has been developed. The approach allows coupling of electron-rich arenes with amino derivatives of electron-deficient heterocycles providing rapid access to scaffolds of bioactive compounds and is based on the application of the hypervalent iodine(III) reagent as an oxidant. Regioselective functionalization of C-H bonds of arenes by the formation of C-N bonds under organocatalytic conditions was demonstrated.
Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie , Otto-Hahn-Straße 11, 44227 Dortmund, Germany.|Fakultät Chemie und Chemische Biologie, Technische Universität Dortmund , Otto-Hahn-Straße 6, 44227 Dortmund, Germany.
Srimanta
S
Manna
Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie , Otto-Hahn-Straße 11, 44227 Dortmund, Germany.|Ural Federal University , 19 Mira Straße, 620002 Ekaterinburg, Russian Federation.
Polina O
PO
Serebrennikova
Ural Federal University , 19 Mira Straße, 620002 Ekaterinburg, Russian Federation.
Irina A
IA
Utepova
Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie , Otto-Hahn-Straße 11, 44227 Dortmund, Germany.|Fakultät Chemie und Chemische Biologie, Technische Universität Dortmund , Otto-Hahn-Straße 6, 44227 Dortmund, Germany.
Andrey P
AP
Antonchick
Ural Federal University , 19 Mira Straße, 620002 Ekaterinburg, Russian Federation.
Oleg N
ON
Chupakhin