Computational Approaches to Nucleic Acid Origami.
Recent advances in experimental DNA origami have dramatically expanded the horizon of DNA nanotechnology. Complex 3D suprastructures have been designed and developed using DNA origami with applications in biomaterial science, nanomedicine, nanorobotics, and molecular computation. Ribonucleic acid (RNA) origami has recently been realized as a new approach. Similar to DNA, RNA molecules can be designed to form complex 3D structures through complementary base pairings. RNA origami structures are, however, more compact and more thermodynamically stable due to RNA's non-canonical base pairing and tertiary interactions. With all these advantages, the development of RNA origami lags behind DNA origami by a large gap. Furthermore, although computational methods have proven to be effective in designing DNA and RNA origami structures and in their evaluation, advances in computational nucleic acid origami is even more limited. In this paper, we review major milestones in experimental and computational DNA and RNA origami and present current challenges in these fields. We believe collaboration between experimental nanotechnologists and computer scientists are critical for advancing these new research paradigms.
Ingenuity Lab , 11421 Saskatchewan Drive, Edmonton, Alberta T6G 2M9, Canada.|Department of Chemical and Materials Engineering, University of Alberta , Edmonton T6G 2V4, Canada.
Hosna
H
Jabbari
Ingenuity Lab , 11421 Saskatchewan Drive, Edmonton, Alberta T6G 2M9, Canada.|Department of Chemical and Materials Engineering, University of Alberta , Edmonton T6G 2V4, Canada.
Maral
M
Aminpour
Ingenuity Lab , 11421 Saskatchewan Drive, Edmonton, Alberta T6G 2M9, Canada.|Department of Chemical and Materials Engineering, University of Alberta , Edmonton T6G 2V4, Canada.
Carlo
C
Montemagno
D020029:Base Pairing; D019295:Computational Biology; D004247:DNA / Q000737:chemistry; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods*; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D012313:RNA / Q000737:chemistry
D009696:Nucleic Acids; D012313:RNA; D004247:DNA
DNA origami; RNA origami; computational approach; nanotechnology