Rh(III)-catalyzed chelation-assisted intermolecular carbenoid functionalization of α-imino Csp(3)-H bonds.
A Rh(iii)-catalyzed cross-coupling/cyclization cascade of α-imino Csp(3)-H bonds with donor/acceptor α-acyl diazocarbonyl compounds has been developed. This novel transformation involves ligand-directed Csp(3)-H bond functionalization with carbenoids under the pyridine-chelation assistance, and offered an efficient access to synthetically versatile polysubstituted N-(2-pyridyl)pyrroles with a broad range of functional group tolerance.
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, China. zengwei@scut.edu.cn.
Xun
X
Chen
Ying
Y
Xie
Xinsheng
X
Xiao
Guoqiang
G
Li
Yuanfu
Y
Deng
Huanfeng
H
Jiang
Wei
W
Zeng