Markedly High B-type Natriuretic Peptide Level in a Patient with Duchenne Muscular Dystrophy and Left Ventricular Non-Compaction.
A boy with Duchenne muscular dystrophy was admitted to our hospital due to a transient loss of consciousness. Transthoracic echocardiography revealed left ventricular (LV) dilatation and diffuse hypokinesis of the LV wall. The LV wall was thin, and both non-compaction of the LV wall and marked thinning of the posterior LV wall resulting from a lesion were observed. The plasma B-type natriuretic peptide (BNP) level ultimately increased to 7,795 pg/mL, and the patient died of cardiac arrest following ventricular tachycardia. Severe heart failure, a critical condition, and thinning of the LV wall may have contributed to the markedly high plasma BNP level in this case.
Department of Cardiology, Kumamoto Saisyunsou Hospital, Japan.
Ikuo
I
Misumi
Yasuto
Y
Nishida
Tsuyoshi
T
Honda
Hirofumi
H
Kurokawa
Hisayo
H
Yasuda
Koichi
K
Kaikita
Seiji
S
Hokimoto
Hisao
H
Ogawa
D000293:Adolescent; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D004232:Diuretics / Q000008:administration & dosage*; D017809:Fatal Outcome; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*
D015415:Biomarkers; D004232:Diuretics; C472955:NPPA protein, human; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor