Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease.
As the level of interest in aging research increases, there is a growing number of geroprotectors, or therapeutic interventions that aim to extend the healthy lifespan and repair or reduce aging-related damage in model organisms and, eventually, in humans. There is a clear need for a manually-curated database of geroprotectors to compile and index their effects on aging and age-related diseases and link these effects to relevant studies and multiple biochemical and drug databases. Here, we introduce the first such resource, Geroprotectors (http://geroprotectors.org). Geroprotectors is a public, rapidly explorable database that catalogs over 250 experiments involving over 200 known or candidate geroprotectors that extend lifespan in model organisms. Each compound has a comprehensive profile complete with biochemistry, mechanisms, and lifespan effects in various model organisms, along with information ranging from chemical structure, side effects, and toxicity to FDA drug status. These are presented in a visually intuitive, efficient framework fit for casual browsing or in-depth research alike. Data are linked to the source studies or databases, providing quick and convenient access to original data. The Geroprotectors database facilitates cross-study, cross-organism, and cross-discipline analysis and saves countless hours of inefficient literature and web searching. Geroprotectors is a one-stop, knowledge-sharing, time-saving resource for researchers seeking healthy aging solutions.
Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar 167982, Russia.|Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia.|Laboratory of Postgenomic Studies, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow 119991, Russia.|School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
Alexey
A
Moskalev
Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia.
Elizaveta
E
Chernyagina
Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.|The Biogerontology Research Foundation, London, UK.
João Pedro
JP
de Magalhães
Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Diogo
D
Barardo
Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Harikrishnan
H
Thoppil
Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar 167982, Russia.
Mikhail
M
Shaposhnikov
The Shraga Segal Department of Microbiology, Immunology, and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva, Israel.|The Judea Regional R&D Center, Carmel, Israel.
Arie
A
Budovsky
The Shraga Segal Department of Microbiology, Immunology, and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Vadim E
VE
Fraifeld
Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia.|Insilico Medicine, Inc., ETC, Johns Hopkins University, B301, Baltimore, MD 21218, USA.
Andrew
A
Garazha
Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia.|The Research Institute for Translational Medicine, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Vasily
V
Tsvetkov
Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka 142432, Russia.
Evgeny
E
Bronovitsky
Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia.
Vladislav
V
Bogomolov
Xpansa, Conzl OU, Tallinn 10616, Estonia.
Alexei
A
Scerbacov
Xpansa, Conzl OU, Tallinn 10616, Estonia.|Infinity Sciences, Inc, Lewes, DE 19958, USA.
Oleg
O
Kuryan
Xpansa, Conzl OU, Tallinn 10616, Estonia.|Infinity Sciences, Inc, Lewes, DE 19958, USA.
Roman
R
Gurinovich
Insilico Medicine, Inc., ETC, Johns Hopkins University, B301, Baltimore, MD 21218, USA.|Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Leslie C
LC
Jellen
Buck Institute for Research on Aging, Novato, CA 94945, USA.
Brian
B
Kennedy
Insilico Medicine, Inc., ETC, Johns Hopkins University, B301, Baltimore, MD 21218, USA.|The Biogerontology Research Foundation, London, UK.
Polina
P
Mamoshina
Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar 167982, Russia.
Evgeniya
E
Dobrovolskaya
Insilico Medicine, Inc., ETC, Johns Hopkins University, B301, Baltimore, MD 21218, USA.|D. Rogachev Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.|The Biogerontology Research Foundation, London, UK.
Alex
A
Aliper
The Biogerontology Research Foundation, London, UK.
Dmitry
D
Kaminsky
Insilico Medicine, Inc., ETC, Johns Hopkins University, B301, Baltimore, MD 21218, USA.|D. Rogachev Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.|The Biogerontology Research Foundation, London, UK.
Alex
A
Zhavoronkov
D000375:Aging / Q000187:drug effects* / Q000235:genetics*; D000818:Animals; D016208:Databases, Factual; D062313:Databases, Pharmaceutical; D005853:Geriatrics; D006801:Humans
aging; body composition; frailty; growth hormone receptor (GHR); lifespan; muscle-specific knockout; pathology