Formula for Unsilencing Plasticity: Spike with GABA.
A complication for developmental plasticity mechanisms like spike-timing-dependent plasticity (STDP) is that immature postsynaptic neurons may lack sufficient input to fire action potentials. In this issue, van Rheede et al. (2015) report an activity-dependent mechanism that converts non-spiking cells into spiking neurons, priming them for further plasticity.
Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Philip
P
Kesner
Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Delphine
D
Gobert
Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address: edward.ruthazer@mcgill.ca.
Edward S
ES
Ruthazer
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013477:Superior Colliculi / Q000166:cytology*; D014785:Vision, Ocular / Q000502:physiology*