Enhancement of bioactivity on medical polymer surface using high power impulse magnetron sputtered titanium dioxide film.
This study utilizes a novel technique, high power impulse magnetron sputtering (HIPIMS), which provides a higher ionization rate and ion bombardment energy than direct current magnetron sputtering (DCMS), to deposit high osteoblast compatible titanium dioxide (TiO2) coatings with anatase (A-TiO2) and rutile (R-TiO2) phases onto the biomedical polyetheretherketone (PEEK) polymer substrates at low temperature. The adhesions of TiO2 coatings that were fabricated using HIPIMS and DCMS were compared. The in vitro biocompatibility of these coatings was confirmed. The results reveal that HIPIMS can be used to prepare crystallinic columnar A-TiO2 and R-TiO2 coatings on PEEK substrate if the ratio of oxygen to argon is properly controlled. According to a tape adhesion test, the HIPIMS-TiO2 coatings had an adhesion grade of 5B even after they were immersed in simulated body fluid (SBF) environments for 28days. Scratch tests proved that HIPIMS-TiO2 coatings undergo cohesive failure. These results demonstrate that the adhesive force between HIPIMS-TiO2 coating/PEEK is stronger than that between DCMS-TiO2 coating/PEEK. After a long period (28days) of immersion in SBF, a bone-like crystallinic hydroxyapatite layer with a corresponding Ca/P stoichiometry was formed on both HIPIMS-TiO2. The osteoblast compatibility of HIPIMS-TiO2 exceeded that of the bare PEEK substrate. It is also noticeable that the R-TiO2 performed better in vitro than the A-TiO2 due to the formation of many negatively charged hydroxyl groups (-OH(-)) groups on R-TiO2 (110) surface. In summary, the HIPIMS-TiO2 coatings satisfied the requirements for osseointegration, suggesting the possibility of using HIPIMS to modify the PEEK surface with TiO2 for spinal implants.
Department of Materials Science and Engineering, Feng Chia University, No. 100, Wenhwa Road, Seatwen District, Taichung City 40724, Taiwan.
Yi-Ju
YJ
Yang
Functional Neurosurgery Division, Neurological Institute, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Seatwen District, Taichung City 40705, Taiwan; Department of Rehabilitation, Jen-Teh Junior College of Medicine, Nursing and Management, No. 79-9, Sha-Luen Hu, Hou-Loung Town, Miaoli County 35664,Taiwan.
Hsi-Kai
HK
Tsou
Department of Materials Science and Engineering, Feng Chia University, No. 100, Wenhwa Road, Seatwen District, Taichung City 40724, Taiwan.
Ying-Hung
YH
Chen
Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, No. 666, Buzih Road, Beitun District, Taichung City 40601, Taiwan. Electronic address: cjchung@seed.net.tw.
Chi-Jen
CJ
Chung
Department of Materials Science and Engineering, Feng Chia University, No. 100, Wenhwa Road, Seatwen District, Taichung City 40724, Taiwan.
Ju-Liang
JL
He
D000818:Animals; D041702:BALB 3T3 Cells; D001577:Benzophenones; D018786:Bone Substitutes / Q000737:chemistry* / Q000528:radiation effects*; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D049109:Cell Proliferation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D007659:Ketones / Q000737:chemistry* / Q000528:radiation effects; D051379:Mice; D008872:Microwaves; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000528:radiation effects; D011108:Polymers; D013499:Surface Properties / Q000528:radiation effects; D014025:Titanium / Q000737:chemistry* / Q000528:radiation effects*
D001577:Benzophenones; D018786:Bone Substitutes; D007659:Ketones; D011108:Polymers; C009495:titanium dioxide; C063834:polyetheretherketone; D011092:Polyethylene Glycols; D014025:Titanium
Film adhesion; High power impulse magnetron sputtering (HIPIMS); Osteoblast compatibility; Polyetheretherketone (PEEK); Titanium dioxide (TiO(2))