Lewis Acid Catalyzed Annulation of Nitrones with Oxiranes, Aziridines, and Thiiranes.
A highly selective Lewis acid catalyzed annulation of three-membered heterocycles with nitrones has been developed. Oxiranes, aziridines, and thiiranes were used as substrates for the synthesis of various six-membered heterocycles using Al or In catalysts. This catalytic protocol demonstrates a broad substrate scope and provides access to new structural motifs in high yields and in excellent selectivity under mild reaction conditions.
Department of Organic Chemistry and ‡Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University , SE-106 91 Stockholm, Sweden.
Stalin R
SR
Pathipati
Department of Organic Chemistry and ‡Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University , SE-106 91 Stockholm, Sweden.
Vipender
V
Singh
Department of Organic Chemistry and ‡Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University , SE-106 91 Stockholm, Sweden.
Lars
L
Eriksson
Department of Organic Chemistry and ‡Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University , SE-106 91 Stockholm, Sweden.
Nicklas
N
Selander