Biological Rhythm and Bipolar Disorder: Twelve-Month Follow-Up of a Randomized Clinical Trial.
The objective was to evaluate the effect of psychoeducation on biological rhythm and in the reduction of depressive, anxious, and manic symptoms at 12 months' follow-up. This was a randomized clinical trial with young adults aged 18 to 29 years, diagnosed with bipolar disorder. Biological rhythm was assessed with the Biological Rhythm Interview Assessment in Neuropsychiatry (BRIAN). Participants were randomized for combined intervention (psychoeducation plus medication) or treatment-as-usual (medication alone). The sample consisted of 61 patients (29 TAU; 32 combined intervention). Although it failed to separate by a marginal difference, the combined intervention seems to be more effective than TAU in relation to improvement of depressive symptoms at post-intervention (p = 0.074) and regulation of sleep/social domain at 6 months' follow-up (p = 0.057). Improvement of depressive symptoms as well as regulation of sleep and social activities are known to prevent episode onset and thus improve long-term outcomes.
*Universidade Católica de Pelotas-Programa de Pós-Graduação em Saúde e Comportamento, Pelotas, Rio Grande do Sul, Brazil; and †Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, TX.
Taiane de Azevedo
Tde A
Cardoso
Thaíse
T
Campos Mondin
Amanda Neumann
AN
Reyes
Cristian Patrick
CP
Zeni
Luciano Dias de Mattos
LD
Souza
Ricardo Azevedo
RA
da Silva
Karen
K
Jansen
D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010353:Patient Education as Topic / Q000379:methods; D011569:Psychiatric Status Rating Scales; D012074:Remission Induction; D055815:Young Adult