Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins.
Protein toxins present considerable health risks, but detection often requires laborious analysis. Here, we developed electrochemical aptamer biosensors for ricin and botulinum neurotoxins, which display robust and specific signal at nanomolar concentrations and function in dilute serum. These biosensors may aid future efforts for the rapid diagnosis of toxins.
Department of Chemistry, Metropolitan State University of Denver, Denver, CO 80204, USA. abonham@msudenver.edu.
Lisa
L
Fetter
Jonathan
J
Richards
Jessica
J
Daniel
Laura
L
Roon
Teisha J
TJ
Rowland
Andrew J
AJ
Bonham
D000818:Animals; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D015374:Biosensing Techniques; D019274:Botulinum Toxins, Type A / Q000032:analysis* / Q000097:blood; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D009690:Nucleic Acid Conformation; D012276:Ricin / Q000032:analysis* / Q000097:blood
D052157:Aptamers, Nucleotide; D004247:DNA; D012276:Ricin; D019274:Botulinum Toxins, Type A