[Malnutrition in early life and cardiovascular disease in adulthood].
Epidemiological and experimental studies have demonstrated that the risk of cardiovascular disease (CVD) in adulthood is influenced by the environment in early life. Intrauterine and early postnatal malnutrition and the following catch-up growth have a long-term effect on blood pressure and endothelial function in adulthood. Well-established prenatal or/and postnatal animal models are used to study the impact of different nutritional intervention on CVD in adulthood. This article reviews the early original cause of chronic CVD in adulthood with the hypothesis of DOHaD (the developmental origins of health and disease), and proposes possible preventions in early life on the basis of this theory.
Department of Neonatology, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;2. Department of Neonatology, Fuzhou Children's Hospital, Fuzhou 350000, China.
Lin-jiang
LJ
Lao
Department of Neonatology, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;2. Department of Neonatology, Fuzhou Children's Hospital, Fuzhou 350000, China.
Li-yan
LY
Zhang
Department of Neonatology, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;2. Department of Neonatology, Fuzhou Children's Hospital, Fuzhou 350000, China.
Li-zhong
LZ
DU
D000818:Animals; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D004195:Disease Models, Animal; D006801:Humans; D044342:Malnutrition