Methodologies and experimental platforms for generating and analysing microarray and mass spectrometry-based omics data to support P4 medicine.
Predictive, preventive, personalized and participatory (P4) medicine is an emerging medical model that is based on the customization of all medical aspects (i.e. practices, drugs, decisions) of the individual patient. P4 medicine presupposes the elucidation of the so-called omic world, under the assumption that this knowledge may explain differences of patients with respect to disease prevention, diagnosis and therapies. Here, we elucidate the role of some selected omics sciences for different aspects of disease management, such as early diagnosis of diseases, prevention of diseases, selection of personalized appropriate and optimal therapies based on molecular profiling of patients. After introducing basic concepts of P4 medicine and omics sciences, we review some computational tools and approaches for analysing selected omics data, with a special focus on microarray and mass spectrometry data, which may be used to support P4 medicine. Some applications of biomarker discovery and pharmacogenomics and some experiences on the study of drug reactions are also described.
Pietro H
PH
Guzzi
Giuseppe
G
Agapito
Marianna
M
Milano
Mario
M
Cannataro
D006801:Humans; D013058:Mass Spectrometry; D046228:Microarray Analysis; D057285:Precision Medicine
P4 medicine; biomarker discovery; genotype-based medicine; pharmacogenomics