title: Multidetector Computed Tomography Features in Differentiating Exophytic Renal Angiomyolipoma from Retroperitoneal Liposarcoma: A Strobe-Compliant Observational Study.
abstract: This study aims to evaluate the multidetector computed tomography (CT) imaging features in differentiating exophytic renal angiomyolipoma (AML) from retroperitoneal liposarcoma. We retrospectively enrolled 42 patients with confirmed exophytic renal AML (31 patients) or retroperitoneal liposarcoma (11 patients) during 8 years period to assess: renal parenchymal defect at site of tumor contact, supply from branches of renal artery, tumoral vessel extending through the renal parenchyma, dilated intratumoral vessels, hemorrhage, non-fat-containing intratumoral nodules with postcontrast enhancement, calcification, renal sinus enlargement, anterior displacement of kidneys, and other associated AML. Renal parenchymal defect, renal arterial blood supply, tumoral vessel through the renal parenchyma, dilated intratumoral vessels, intratumoral/perirenal hemorrhage, renal sinus enlargement, and associated AML were seen only or mainly in exophytic renal AML (all P value < 0.05); however, non-fat-attenuating enhancing intratumoral nodules, intratumoral calcification, and anterior displacement of the kidney were more common in liposarcoma (all P value < 0.05). AMLs reveal renal parenchymal defect at the site of tumor contact, supply from renal artery, tumoral vessel extending through the renal parenchyma, dilated intratumoral vessels, intratumoral and/or perirenal hemorrhage, renal sinus enlargement, and associated AML. Non-fat-attenuating enhancing intratumoral nodules, intratumoral calcifications, and anterior displacement of kidney were more commonly seen in liposarcoma.
authors.affiliation: From the Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, GuangZhou, GuangDong, China (QW, J-JX, HL, HH, ZL, JZ, CL); Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan (Y-HJ); Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan (Y-HJ); Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, GuangZhou, GuangDong, China (YL); Schepens Eye Research Institute, Harvard Medical School, Boston, MA (USS); and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX (SSS).
authors.forename: Qiushi
authors.initials: Q
authors.lastname: Wang
authors.forename: Yu-Hsiang
authors.initials: YH
authors.lastname: Juan
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Xie
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Hongfei
authors.initials: H
authors.lastname: Huang
authors.forename: Zaiyi
authors.initials: Z
authors.lastname: Liu
authors.forename: Junhui
authors.initials: J
authors.lastname: Zheng
authors.forename: Ujwala S
authors.initials: US
authors.lastname: Saboo
authors.forename: Sachin S
authors.initials: SS
authors.lastname: Saboo
authors.forename: Changhong
authors.initials: C
authors.lastname: Liang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018207:Angiomyolipoma / Q000098:blood supply / Q000150:complications / Q000175:diagnosis*; D002114:Calcinosis; D003937:Diagnosis, Differential; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000098:blood supply / Q000150:complications / Q000175:diagnosis*; D008080:Liposarcoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D012077:Renal Artery / Q000473:pathology; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis*; D012189:Retrospective Studies; D055815:Young Adult