title: Search for aflatoxin and trichothecene production inhibitors and analysis of their modes of action.
abstract: Mycotoxin contamination of crops is a serious problem throughout the world because of its impact on human and animal health as well as economy. Inhibitors of mycotoxin production are useful not only for developing effective methods to prevent mycotoxin contamination, but also for investigating the molecular mechanisms of secondary metabolite production by fungi. We have been searching for mycotoxin production inhibitors among natural products and investigating their modes of action. In this article, we review aflatoxin and trichothecene production inhibitors, including our works on blasticidin S, methyl syringate, cyclo(L-Ala-L-Pro), respiration inhibitors, and precocene II.
authors.affiliation: a Department of Applied Biological Chemistry , The University of Tokyo , Tokyo , Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Sakuda
authors.affiliation: b Division of Microbiology , National Institute of Health Sciences , Tokyo , Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Yoshinari
authors.affiliation: a Department of Applied Biological Chemistry , The University of Tokyo , Tokyo , Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Furukawa
authors.affiliation: c Faculty of Veterinary Medicine, Department of Pharmacology , Kasetsart University , Bangkok , Thailand.
authors.forename: Usuma
authors.initials: U
authors.lastname: Jermnak
authors.affiliation: a Department of Applied Biological Chemistry , The University of Tokyo , Tokyo , Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Takagi
authors.affiliation: a Department of Applied Biological Chemistry , The University of Tokyo , Tokyo , Japan.
authors.forename: Kurin
authors.initials: K
authors.lastname: Iimura
authors.affiliation: a Department of Applied Biological Chemistry , The University of Tokyo , Tokyo , Japan.
authors.forename: Toshiyoshi
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: a Department of Applied Biological Chemistry , The University of Tokyo , Tokyo , Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: a Department of Applied Biological Chemistry , The University of Tokyo , Tokyo , Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Nagasawa
mesh_terms: D000348:Aflatoxins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D001230:Aspergillus / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D001578:Benzopyrans / Q000494:pharmacology; D018556:Crops, Agricultural / Q000187:drug effects / Q000382:microbiology; D005506:Food Contamination / Q000517:prevention & control*; D005659:Fungicides, Industrial / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D009705:Nucleosides / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000494:pharmacology; D010935:Plant Diseases / Q000382:microbiology; D013329:Structure-Activity Relationship; D014255:Trichothecenes / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D000348:Aflatoxins; D001578:Benzopyrans; D005659:Fungicides, Industrial; D009705:Nucleosides; D009822:Oils, Volatile; D010456:Peptides, Cyclic; D014255:Trichothecenes; C506133:methyl syringate; C014163:precocene II; D005707:Gallic Acid; C004500:blasticidin S
keywords: aflatoxin; biocontrol; mycotoxin; precocene; trichothecene