title: miR-506 Inhibits Epithelial-to-Mesenchymal Transition and Angiogenesis in Gastric Cancer.
abstract: Gastric cancer is one of the most common malignancies in developing countries. We examined the possible role of miR-506 in gastric cancer, investigated its associations with the clinical outcomes of gastric cancer patients, and explored its potential role in angiogenesis and the metastasis of gastric cancer cells. We found that miR-506 expression was a useful marker for stratifying patients from early to advanced clinical stages and for overall survival prediction. miR-506 overexpression inhibited the epithelial-to-mesenchymal transition of gastric cancer cells; however, depletion of miR-506 promoted it. In addition, miR-506 suppressed gastric cancer angiogenesis and was associated with decreased matrix metalloproteinase-9 expression. We also found that ETS1 was a miR-506 target, and it was expressed in 71.10% of gastric cancer tissue samples. Moreover, ETS1 expression was associated with matrix metalloproteinase-9 expression (P < 0.001). In conclusion, miR-506 was identified as an ETS1 targeting suppressor of metastatic invasion and angiogenesis in gastric cancer.
authors.affiliation: Cancer Research Institute of Southern Medical University, Guangzhou, People's Republic of China; Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Cancer Research Institute of Southern Medical University, Guangzhou, People's Republic of China; Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Suwei
authors.initials: S
authors.lastname: Dong
authors.affiliation: Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tan
authors.affiliation: Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Ge
authors.affiliation: Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Ruilei
authors.initials: R
authors.lastname: Li
authors.affiliation: Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Yuanbo
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department Pathology, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: Department Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Xiang
authors.affiliation: Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Jinyan
authors.initials: J
authors.lastname: Yang
authors.affiliation: Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Ding
authors.affiliation: Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Geng
authors.affiliation: Cancer Research Institute of Southern Medical University, Guangzhou, People's Republic of China. Electronic address: ktyao@fimmu.com.
authors.forename: Kaitai
authors.initials: K
authors.lastname: Yao
authors.affiliation: Cancer Research Institute of Southern Medical University, Guangzhou, People's Republic of China; Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, People's Republic of China. Electronic address: songxin68@126.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D015536:Down-Regulation; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics*; D013274:Stomach Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology
chemical_list: C561508:MIRN506 microRNA, human; D035683:MicroRNAs