title: A systematic review on the applications of resting-state fMRI in Parkinson's disease: Does dopamine replacement therapy play a role?
abstract: Functional neuroimaging techniques provide important insight into the pathophysiology of neurodegenerative disorders such as Parkinson's disease (PD) in-vivo. Recently, resting-state functional magnetic resonance imaging (rs-fMRI) has been applied as a non-invasive tool in many studies to assess functional abnormalities observed in PD without the effects of particular motor or cognitive tasks. In this review, we summarized 50 original PD rs-fMRI studies and subdivided them based on the medication status of the patients to highlight the impact of dopamine replacement therapy (DRT) when rs-fMRI was used to assess patients with PD. Although there are many different published approaches to analyzing rs-fMRI in PD, it seems that DRT plays a critical role in the functional reorganization of the brain throughout all of these approaches. In particular, studies that compared PD patients with and without medication demonstrated that DRT normalizes aberrant functional patterns in PD and leads to an improvement of PD symptoms. Thus, researchers should consider DRT as a confounding factor, which could result in misinterpretations. We suggest that performing rs-fMRI in de novo patients could be a method of choice to study the fundamental functional abnormalities in PD independent of the effects of DRT. However, it is necessary to carefully control for excessive involuntary head motions in the patients not receiving DRT. On the other hand, recruiting patients under daily DRT might be favorable to assess particular interventions in clinical routine.
authors.affiliation: Department of Neurology, University Hospital of Cologne, Cologne, Germany; Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany; Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran. Electronic address: masoud.tahmasian@uk-koeln.de.
authors.forename: Masoud
authors.initials: M
authors.lastname: Tahmasian
authors.affiliation: Department of Neurology, University Hospital of Cologne, Cologne, Germany.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Bettray
authors.affiliation: Department of Neurology, University Hospital of Cologne, Cologne, Germany; Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany.
authors.forename: Thilo
authors.initials: T
authors.lastname: van Eimeren
authors.affiliation: Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Drzezga
authors.affiliation: Department of Neurology, University Hospital of Cologne, Cologne, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Timmermann
authors.affiliation: Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Aachen, Germany.
authors.forename: Claudia R
authors.initials: CR
authors.lastname: Eickhoff
authors.affiliation: Institute of Clinical Neuroscience & Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
authors.affiliation: Department of Neurology, University Hospital of Cologne, Cologne, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Eggers
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism / Q000627:therapeutic use*; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D004298:Dopamine
keywords: Dopamine replacement therapy; Functional connectivity; Parkinson's disease; Resting-state fMRI