title: EZH2 is a sensitive marker of malignancy in salivary gland tumors.
abstract: BACKGROUND
  The immunohistochemical detection of Enhancer of zeste homologue 2 (EZH2) proved to be a useful tool to recognize the malignant nature of tumors in a wide variety of neoplasms. The histological diagnostics of salivary gland tumors is a challenging task, and a reliable marker of malignancy would be extremely helpful.
  
  
  METHODS
  EZH2 expression was investigated in 54 malignant and 40 benign salivary gland tumors of various histological types by standard immunohistochemistry.
  
  
  RESULTS
  The majority (n = 52) of the malignant tumors stained positively, while all the investigated benign tumors were negative for EZH2.
  
  
  CONCLUSIONS
  EZH2 expression in salivary gland tumors, similarly to the tumors of other organs is not characteristic for any tumor type, but is a solid marker of the malignant nature of the tumors.
authors.affiliation: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, H-1085, Hungary.|Heim Pál Children's Hospital, Budapest, Hungary.
authors.forename: Szofia
authors.initials: S
authors.lastname: Hajósi-Kalcakosz
authors.affiliation: Pathology Department, National Institute of Oncology, Budapest, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Vincze
authors.affiliation: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, H-1085, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Dezső
authors.affiliation: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, H-1085, Hungary.|Tumor Progression Research Group, Joint Research Organization of the Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.
authors.forename: Sándor
authors.initials: S
authors.lastname: Paku
authors.affiliation: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, H-1085, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Rókusz
authors.affiliation: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, H-1085, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Sápi
authors.affiliation: Pathology Department, National Institute of Oncology, Budapest, Hungary.
authors.forename: Erika
authors.initials: E
authors.lastname: Tóth
authors.affiliation: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, H-1085, Hungary. pdrnagy@gmail.com.
authors.forename: Péter
authors.initials: P
authors.lastname: Nagy
mesh_terms: D000236:Adenoma / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology*; D000071221:Enhancer of Zeste Homolog 2 Protein; D006801:Humans; D007150:Immunohistochemistry; D063151:Polycomb Repressive Complex 2 / Q000032:analysis / Q000096:biosynthesis*; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2