title: Novel agents for advanced pancreatic cancer.
abstract: Pancreatic cancer is relatively insensitive to conventional chemotherapy. Therefore, novel agents targeting dysregulated pathways (MAPK/ERK, EGFR, TGF-β, HEDGEHOG, NOTCH, IGF, PARP, PI3K/AKT, RAS, and Src) are being explored in clinical trials as monotherapy or in combination with cytotoxic chemotherapy. This review summarizes the most recent advances with the targeted therapies in the treatment of patients with advanced pancreatic cancer.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, New York Medical College, Valhalla, New York, United States.
authors.forename: Akintunde
authors.initials: A
authors.lastname: Akinleye
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, New York Medical College, Valhalla, New York, United States.
authors.forename: Chaitanya
authors.initials: C
authors.lastname: Iragavarapu
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, University of Iowa, Iowa City, Iowa, United States.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Furqan
authors.affiliation: Department of Oncology, Henan Province People's Hospital, Zhengzhou University, Zhengzhou, China.
authors.forename: Shundong
authors.initials: S
authors.lastname: Cang
authors.affiliation: Department of Oncology, Henan Cancer Hospital and the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Delong
authors.initials: D
authors.lastname: Liu
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D054852:Small Molecule Libraries / Q000627:therapeutic use*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D018796:Immunoconjugates; D054852:Small Molecule Libraries
keywords: IGF-1R; pancreatic cancer