title: REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers.
abstract: BACKGROUND
  Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established.
  
  
  METHODS
  One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire.
  
  
  RESULTS
  Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P < 0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P < 0.05).
  
  
  CONCLUSIONS
  A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.
authors.affiliation: Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA.|Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Saunders-Pullman
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Roy N
authors.initials: RN
authors.lastname: Alcalay
authors.affiliation: Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sieratzki Chair of Neurology, Department of Neurology and Neurosurgery, Sackler School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Anat
authors.initials: A
authors.lastname: Mirelman
authors.affiliation: Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: Cuiling
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, California, USA.
authors.forename: Marta San
authors.initials: MS
authors.lastname: Luciano
authors.affiliation: Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA.
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Ortega
authors.affiliation: Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Glickman
authors.affiliation: Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Raymond
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Helen
authors.initials: H
authors.lastname: Mejia-Santana
authors.affiliation: Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA.
authors.forename: Nancy
authors.initials: N
authors.lastname: Doan
authors.affiliation: Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA.
authors.forename: Brooke
authors.initials: B
authors.lastname: Johannes
authors.affiliation: Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sieratzki Chair of Neurology, Department of Neurology and Neurosurgery, Sackler School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Kira
authors.initials: K
authors.lastname: Yasinovsky
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Department of Genetics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Laurie
authors.initials: L
authors.lastname: Ozelius
authors.affiliation: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Clark
authors.affiliation: Genetic Institute, Tel-Aviv Medical Center, Sackler School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Avi
authors.initials: A
authors.lastname: Orr-Utreger
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.|Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA.|Department of Psychiatry, Columbia University Medical Center, New York, New York, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Marder
authors.affiliation: Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sieratzki Chair of Neurology, Department of Neurology and Neurosurgery, Sackler School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Nir
authors.initials: N
authors.lastname: Giladi
authors.affiliation: Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA.|Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Susan B
authors.initials: SB
authors.lastname: Bressman
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005973:Glutamine / Q000235:genetics*; D006801:Humans; D007599:Judaism; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010300:Parkinson Disease / Q000175:diagnosis* / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012694:Serine / Q000235:genetics*; D012892:Sleep Deprivation / Q000175:diagnosis / Q000235:genetics*; D011795:Surveys and Questionnaires
chemical_list: D005973:Glutamine; D012694:Serine; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases
keywords: LRRK2; Parkinson's disease; RBDSQ; REM Behavior Disorder; preclinical