title: A study on the association of rs7950273 polymorphism in the PDGFD with ischaemic stroke in the Chinese Han population.
abstract: BACKGROUND
  The association between the platelet-derived growth factor D (PDGFD) gene and atherosclerosis has been widely proven, whereas the relationship between the PDGFD gene and ischaemic stroke remains unconfirmed.
  
  
  OBJECTIVE
  A case-control study was performed to further evaluate the association of the C → G mutation of rs7950273 in the PDGFD gene with ischaemic stroke (IS) in a Chinese Han population.
  
  
  METHODS
  This study recruited 3033 cases and 2807 controls from general hospitals in the southern, central and northern areas of China. The MGB probe and Taqman 7900HT Sequence Detection System were applied for genotyping.
  
  
  RESULTS
  Genotype was not significantly associated with ischaemic stroke in total. After adjustment for gender, age, BMI, hypertension, diabetes mellitus and smoking, the CG and GG genotypes were still not associated with ischaemic stroke (p = 0.892 and p = 0.582 for CG and GG, respectively).
  
  
  CONCLUSIONS
  This study suggests that the polymorphism of rs7950273 in the PDGFD gene is not associated with ischaemic stroke in the Chinese Han population. Further studies on the gene-gene and gene-environment interactions for the PDGFD gene and ischaemic stroke are needed.
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery , Guang Dong Medical College FuTian Hospital , Shenzhen , PR China and.
authors.forename: Jingjun
authors.initials: J
authors.lastname: Han
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery , Guang Dong Medical College FuTian Hospital , Shenzhen , PR China and.
authors.forename: Huanlian
authors.initials: H
authors.lastname: Li
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery , Guang Dong Medical College FuTian Hospital , Shenzhen , PR China and.
authors.forename: Deqiang
authors.initials: D
authors.lastname: Wu
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery , Guang Dong Medical College FuTian Hospital , Shenzhen , PR China and.
authors.forename: Nafen
authors.initials: N
authors.lastname: Zeng
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery , Guang Dong Medical College FuTian Hospital , Shenzhen , PR China and.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Wu
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery , Guang Dong Medical College FuTian Hospital , Shenzhen , PR China and.
authors.forename: Longgan
authors.initials: L
authors.lastname: Cai
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery , Guang Dong Medical College FuTian Hospital , Shenzhen , PR China and.
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Chen
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery , Guang Dong Medical College FuTian Hospital , Shenzhen , PR China and.
authors.forename: Wei
authors.initials: W
authors.lastname: Zuo
authors.affiliation: b Key Laboratory of Molecular Biology of Shenzhen, Center for Disease Control and Prevention , Shenzhen , PR China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002545:Brain Ischemia / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003920:Diabetes Mellitus / Q000208:ethnology / Q000235:genetics; D005260:Female; D059647:Gene-Environment Interaction; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008222:Lymphokines / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000208:ethnology* / Q000235:genetics*; D011795:Surveys and Questionnaires
chemical_list: D008222:Lymphokines; C427493:PDGFD protein, human; D010982:Platelet-Derived Growth Factor
keywords: Ischaemic stroke; PDGFD; polymorphism