title: Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers.
abstract: A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 °C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions.
authors.forename: Fei
authors.initials: F
authors.lastname: Tian
authors.forename: Jouha
authors.initials: J
authors.lastname: Min
authors.forename: Jiri
authors.initials: J
authors.lastname: Kanka
authors.forename: Xiangzhi
authors.initials: X
authors.lastname: Li
authors.forename: Paula T
authors.initials: PT
authors.lastname: Hammond
authors.forename: Henry
authors.initials: H
authors.lastname: Du