title: Adult weight gain and risk of prostate cancer: A dose-response meta-analysis of observational studies.
abstract: The association between adult weight gain and risk of prostate cancer has not been widely studied and the findings are inconsistent. Therefore, our study aimed to investigate the association between adult weight gain and risk of prostate cancer. PubMed, Embase and Web of Science databases were searched for relevant studies published before September 2014 using terms related to weight gain and prostate cancer. Summary estimates were obtained using the random-effects model. Dose-response meta-analysis, sensitivity analysis and publication bias tests were performed. Nine studies involving 497,634 participants and 22,338 cancer cases were included. For total prostate cancer, a positive relationship with adult weight gain was observed until weight gain increased to >30 kg. For low-intermediate-risk prostate cancer, a positive relationship with adult weight gain was observed until weight gain increased to >15 kg. For high-risk prostate cancer, we observed a positive linear relationship with adult weight gain with a relative risk (RR) of 1.02 [95% confidence interval (CI) 1.00-1.04] for every 5-kg increase. For fatal prostate cancer, we observed a positive linear relationship with adult weight gain with an RR of 1.12 (95% CI: 1.05-1.19) for every 5-kg increase. There is evidence that adult weight gain is associated with an increased risk of high-risk and fatal prostate cancer, but only low weight gain is positively associated with low-intermediate-risk prostate cancer.
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Changhai Hospital, Shanghai, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Shi
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Tianyi
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Urology, Changhai Hospital, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Division of Undergraduate, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wei
authors.affiliation: Division of Undergraduate, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Yuzhou
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Jia
authors.initials: J
authors.lastname: He
mesh_terms: D006801:Humans; D008297:Male; D064887:Observational Studies as Topic; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D015430:Weight Gain / Q000502:physiology*
keywords: adult weight gain; meta-analysis; prostate cancer