title: Prognostic interaction patterns in diabetes mellitus II: A random-matrix-theory relation.
abstract: We analyze protein-protein interactions in diabetes mellitus II and its normal counterpart under the combined framework of random matrix theory and network biology. This disease is the fifth-leading cause of death in high-income countries and an epidemic in developing countries, affecting around 8% of the total adult population in the world. Treatment at the advanced stage is difficult and challenging, making early detection a high priority in the cure of the disease. Our investigation reveals specific structural patterns important for the occurrence of the disease. In addition to the structural parameters, the spectral properties reveal the top contributing nodes from localized eigenvectors, which turn out to be significant for the occurrence of the disease. Our analysis is time-efficient and cost-effective, bringing a new horizon in the field of medicine by highlighting major pathways involved in the disease. The analysis provides a direction for the development of novel drugs and therapies in curing the disease by targeting specific interaction patterns instead of a single protein.
authors.affiliation: Centre for Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore 452017, India.
authors.forename: Aparna
authors.initials: A
authors.lastname: Rai
authors.affiliation: Centre for Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore 452017, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Pawar
authors.affiliation: Centre for Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore 452017, India.|Complex Systems Lab, Discipline of Physics, Indian Institute of Technology Indore, Indore 452017, India.
authors.forename: Sarika
authors.initials: S
authors.lastname: Jalan
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011379:Prognosis; D040901:Proteomics / Q000379:methods