title: Successful Pregnancy Following Assisted Reproduction in Woman With Systemic Lupus Erythematosus and Hypertension: A Case Report.
abstract: Patients with systemic lupus erythematosus have a poor prognosis of pregnancy, since it is associated with significant maternal and fetal morbidity, including spontaneous miscarriage, pre-eclampsia, intrauterine growth restriction, fetal death and pre-term delivery. We report a case with successful pregnancy in a patient with systemic lupus erythematosus and hypertension. A 39-year-old nulliparous woman presented with systemic lupus erythematosus with antinuclear and antiphospholipid antibodies, hypertension and recurrent pregnancy loss presented for assisted reproduction. The patient responded well to enoxaparin and prednisone during both assisted reproduction and prenatal treatment. This case report indicates that prescription of immunosuppressant and blood thinners can be safely recommended throughout the whole prenatal period in patients with systemic lupus erythematosus. Enoxaparin and prednisone may be prescribed concurrently during pregnancy.
authors.affiliation: From Reproferty Reproductive Medicine Clinic, Sao Jose dos Campos, São Paulo, Brazil (JFdM, GCdM, LAC); Center of Innovation, Technology and Education (CITE), Camilo Castelo Branco University, Sao Jose dos Campos, Sao Paulo, Brazil (JFdM, LAC, OCB); and Faculty of Medicine, Estácio de Sá University, Rio de Janeiro, Brazil (GCDM).
authors.forename: José Fernando
authors.initials: JF
authors.lastname: de Macedo
authors.forename: Gustavo Capinzaiki
authors.initials: GC
authors.lastname: de Macedo
authors.forename: Luciana Aparecida
authors.initials: LA
authors.lastname: Campos
authors.forename: Ovidiu Constantin
authors.initials: OC
authors.lastname: Baltatu
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension; D008180:Lupus Erythematosus, Systemic; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D027724:Reproductive Techniques, Assisted