title: Acrylate Systemic Contact Dermatitis.
abstract: Acrylates, the 2012 American Contact Dermatitis Society allergen of the year, are found in a range of products including the absorbent materials within feminine hygiene pads. When fully polymerized, acrylates are nonimmunogenic; however, if not completely cured, the monomers can be potent allergens.A 28-year-old woman is presented, who had her teeth varnished with Isodan (Septodont, Saint-Maur-des-Fossés, France) containing HEMA (2-hydroxyethyl methacrylate) with no initial reaction. Approximately 1 month later, the patient developed a genital dermatitis secondary to her feminine hygiene pads. The initial reaction resolved, but 5 months later, the patient developed a systemic contact dermatitis after receiving a second varnishing.The patient was dramatically patch test positive to many acrylates. This case demonstrates a reaction to likely unpolymerized acrylates within a feminine hygiene pad, as well as broad cross-reactivity or cosensitivity to acrylates, and possibly a systemic contact dermatitis with systemic re-exposure to unpolymerized acrylates.
authors.affiliation: From the Division of Dermatology, Department of Medicine, University of Ottawa/The Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: Maxwell B
authors.initials: MB
authors.lastname: Sauder
authors.forename: Melanie D
authors.initials: MD
authors.lastname: Pratt
mesh_terms: D000179:Acrylates / Q000009:adverse effects*; D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D052576:Menstrual Hygiene Products / Q000009:adverse effects*; D008689:Methacrylates / Q000009:adverse effects*; D009566:Nitrates / Q000009:adverse effects*; D012969:Sodium Fluoride / Q000009:adverse effects*
chemical_list: D000179:Acrylates; C473099:Isodan; D008689:Methacrylates; D009566:Nitrates; D012969:Sodium Fluoride