title: An Update on Treatment of Drug-Induced Liver Injury.
abstract: Drug-induced liver injury (DILI) has been linked to more than 1,000 medications and remains the most common cause of acute liver failure in the United States. Here, we review the most current literature regarding treatment and make recommendations for the management of this relatively common disease. Since treatment of DILI remains largely elusive, recent studies have attempted to define new management strategies for these difficult patients. Early diagnosis and withdrawal of the suspected medication is the mainstay of treatment of DILI. For acetaminophen and Amanita mushroom poisoning, there are specific therapies in use. Finally, there are other possible management modalities for DILI, including corticosteroids and ursodeoxycholic acid.
authors.affiliation: Department of Faculty and Academic Affairs, University of Central Florida, College of Medicine, Orlando, FL, USA.
authors.forename: Christin
authors.initials: C
authors.lastname: Giordano
authors.affiliation: Digestive Disease Institute, Cleveland Clinic Florida, Weston, FL, USA.
authors.forename: John
authors.initials: J
authors.lastname: Rivas
authors.affiliation: Digestive Disease Institute, Cleveland Clinic Florida, Weston, FL, USA.
authors.forename: Xaralambos
authors.initials: X
authors.lastname: Zervos
keywords: Acetaminophen toxicity; Drug-induced liver injury; Hepatotoxicity