title: Are Microalbuminuria and Elevated 24 H Urinary Microalbumin Excretion within Normal Range Associated with Metabolic Syndrome in Chinese Adults?
abstract: The association of microalbuminuria and elevated 24 h urinary microalbumin excretion (UAE) with metabolic syndrome (MetS) has not been well examined in Chinese Adults. In the present study, a population-based cross-sectional study was conducted among Chinese adults aged 18-69 years in Shandong province in 2011 to determine the relationship between them. Data on 24 h UAE and other variables were obtained and components of MetS were examined. The prevalence of MetS and mean 24 h UAE was 24.7% and 6.7 mg, respectively. Compared with participants with normoalbuminuria, the odds of MetS and its components including central obesity, elevated blood pressure and elevated fasting glucose, but not the odds of low HDL cholesterol and elevated triglycerides, significantly increased in those with microalbuminuria. Additionally, the odds of MetS and its three components significantly increased across increasing quartiles of 24 h UAE within normal range (1.00, 1.11, 1.02 and 1.58, respectively, for MetS; 1.00, 1.14, 1.21, and 1.68, respectively, for central obesity; 1.00, 1.35, 1.26 and 1.68, respectively, for elevated blood pressure; and 1.00, 1.32, 1.06 and 1.47, respectively, for elevated triglycerides; p for linear trend ≤0.05 for all). Furthermore, for each increment of 10 mg 24 h UAE within normal range, the odds of MetS and its components including central obesity, elevated blood pressure, and elevated triglycerides significantly increased by 53%, 65%, 55%, and 41%, respectively. These findings suggest that both microalbuminuria and elevated 24 h UAE within normal range might be important risk factors for MetS in Chinese adults.
authors.affiliation: National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Ge
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Guo
authors.affiliation: National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan, China.
authors.forename: Jiyu
authors.initials: J
authors.lastname: Zhang
authors.affiliation: National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Liuxia
authors.initials: L
authors.lastname: Yan
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Tang
authors.affiliation: National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Cai
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan, China.
authors.forename: Aiqiang
authors.initials: A
authors.lastname: Xu
authors.affiliation: National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Jixiang
authors.initials: J
authors.lastname: Ma
mesh_terms: D000328:Adult; D000418:Albumins / Q000378:metabolism*; D000419:Albuminuria / Q000097:blood* / Q000150:complications* / Q000378:metabolism; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology* / Q000378:metabolism; D056128:Obesity, Abdominal / Q000097:blood / Q000150:complications / Q000378:metabolism; D015995:Prevalence; D012016:Reference Values; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D000418:Albumins; D014280:Triglycerides