title: The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
abstract: Piezo1 and Piezo2 are critically required for nonselective cationic mechanosensitive channels in mammalian cells. Within the last 5 years, tremendous progress has been made in understanding the function of Piezo1/2 in embryonic development, physiology, and associated disease states. A recent breakthrough was the discovery of a chemical opener for Piezo1, indicating that mechanosensitive ion channels can be opened independently of mechanical stress. We will review these new exciting findings, which might pave the road for the identification of novel therapeutic strategies.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, Valbonne, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Honoré
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, Valbonne, France.
authors.forename: Joana Raquel
authors.initials: JR
authors.lastname: Martins
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, Valbonne, France.
authors.forename: David
authors.initials: D
authors.lastname: Penton
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, Valbonne, France.
authors.forename: Amanda
authors.initials: A
authors.lastname: Patel
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, Valbonne, France. demolombe@ipmc.cnrs.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Demolombe
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology*; D008969:Molecular Sequence Data; D059225:Nociception; D013314:Stress, Mechanical; D050396:TRPP Cation Channels / Q000502:physiology; D014110:Touch
chemical_list: D007473:Ion Channels; C515204:PIEZO1 protein, human; C000589132:PIEZO2 protein, human; D050396:TRPP Cation Channels
keywords: Electrophysiology; Mechanosensation; Mechanotransduction; Piezo1; Piezo2; Xerocytosis