title: Research into cancer metabolomics: Towards a clinical metamorphosis.
abstract: The acknowledgement that metabolic reprogramming is a central feature of cancer has generated high expectations for major advances in both diagnosis and treatment of malignancies through addressing metabolism. These have so far only been partially fulfilled, with only a few clinical applications. However, numerous diagnostic and therapeutic compounds are currently being evaluated in either clinical trials or pre-clinical models and new discoveries of alterations in metabolic genes indicate future prognostic or other applicable relevance. Altogether, these metabolic approaches now stand alongside other available measures providing hopes for the prospects of metabolomics in the clinic. Here we present a comprehensive overview of both ongoing and emerging clinical, pre-clinical and technical strategies for exploiting unique tumour metabolic traits, highlighting the current promises and anticipations of research in the field.
authors.affiliation: Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.
authors.forename: Orianne
authors.initials: O
authors.lastname: Olivares
authors.affiliation: Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, UK.
authors.forename: J Henry M
authors.initials: JHM
authors.lastname: Däbritz
authors.affiliation: Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.
authors.forename: Ayala
authors.initials: A
authors.lastname: King
authors.affiliation: Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, UK. Electronic address: e.gottlieb@beatson.gla.ac.uk.
authors.forename: Eyal
authors.initials: E
authors.lastname: Gottlieb
authors.affiliation: Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK. Electronic address: chris.halsey@glasgow.ac.uk.
authors.forename: Christina
authors.initials: C
authors.lastname: Halsey
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D055432:Metabolomics; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology
chemical_list: D000964:Antimetabolites, Antineoplastic
keywords: Biomarkers; Cancer metabolism; Cancer therapeutics; Clinical trials; Imaging