title: Transplacental Administration of Rosiglitazone Attenuates Hyperoxic Lung Injury in a Preterm Rabbit Model.
abstract: BACKGROUND
  Continuous improvements in perinatal care have allowed the survival of increasingly more prematurely born infants. The establishment of respiration in an extremely immature yet still developing lung results in chronic lung injury with significant mortality and morbidity. We experimentally evaluated a novel medical strategy to prevent hyperoxia-induced lung injury by prenatal rosiglitazone.
  
  
  METHODS
  Pregnant rabbits were injected with saline or rosiglitazone (3 mg/kg) 48 and 24 h prior to preterm delivery at 28 days of gestation (term = 31 days). The pups were held in normoxia (21% O2) or hyperoxia (>95% O2), and assessment was done at three different time points (1 h, 24 h and 7 days).
  
  
  RESULTS
  The administration of rosiglitazone resulted in a significant decrease in tissue damping (resistance) on day 7. Furthermore, significantly increased expression of vascular endothelial growth factor, fetal liver kinase 1 and surfactant protein B immediately after delivery was noted by immunohistochemistery. On day 7, there was a more mature lung parenchymal architecture in rosiglitazone-exposed pups.
  
  
  CONCLUSIONS
  In a preterm rabbit model, prenatal maternal administration of rosiglitazone attenuates neonatal hyperoxic lung injury and results in a more mature pulmonary parenchyma.
authors.affiliation: Department of Development and Regeneration, Organ System Cluster, Faculty of Medicine, KU Leuven, Leuven, Belgium.
authors.forename: Jute
authors.initials: J
authors.lastname: Richter
authors.forename: Jaan
authors.initials: J
authors.lastname: Toelen
authors.forename: Taro
authors.initials: T
authors.lastname: Nagatomo
authors.forename: Julio
authors.initials: J
authors.lastname: Jimenez
authors.forename: Jeroen
authors.initials: J
authors.lastname: Vanoirbeek
authors.forename: Jan
authors.initials: J
authors.lastname: Deprest
mesh_terms: D000818:Animals; D005260:Female; D018496:Hyperoxia / Q000188:drug therapy*; D055370:Lung Injury / Q000517:prevention & control*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D047928:Premature Birth; D011817:Rabbits; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D045162:Thiazolidinediones; D000077154:Rosiglitazone