title: The science of reperfusion injury post cardiac arrest--Implications for emergency nurses.
abstract: Survival following cardiac arrest in the developed world remains below 10%. In those who survive the initial cardiac arrest, prognosis remains poor due to the onset of multi-organ failure with both significant cardiac and neurological dysfunction. Nurses have demonstrated good understanding of cardiac arrest/post arrest guidelines and have good technical skills but deficits remain in their understanding of pathophysiological processes involved in post cardiac arrest syndromes. This article aims to provide an overview of these pathophysiological processes involved in the post cardiac arrest phase, potential treatment options and the nursing interventions that may be required within the emergency department setting. This article will focus emergency nurses to become more involved in patient management at this critical phase of treatment and highlight potential early signs of deterioration. Although return of spontaneous circulation (ROSC) is crucial in the process of recovery from cardiac arrest, it is only the first of many complex stages. Given the complexity of post cardiac arrest syndrome and its impact on the patient, healthcare professionals need to understand the cellular changes associated with reperfusion injuries in order to improve outcomes. It is only through effective nursing care and medical management that improved outcomes will become more common in the future.
authors.affiliation: Emergency Department, King's College Hospital NHS Trust, Denmark Hill, London SE5 9RS, United Kingdom. Electronic address: edwardbaker@nhs.net.
authors.forename: Edward
authors.initials: E
authors.lastname: Baker
authors.affiliation: King's College London, James Clerk Maxwell Building, 57, Waterloo Road, Waterloo, London SW1 8WA, United Kingdom.
authors.forename: Geraldine
authors.initials: G
authors.lastname: Lee
mesh_terms: D016529:Emergency Nursing / Q000193:education / Q000379:methods; D006323:Heart Arrest / Q000150:complications / Q000401:mortality* / Q000503:physiopathology*; D006801:Humans; D008660:Metabolism / Q000502:physiology; D009726:Nurses; D015427:Reperfusion Injury / Q000401:mortality / Q000503:physiopathology*; D000078329:Workforce
keywords: Emergency nurse; Extracorporeal membrane oxygenation; Hypothermia; Reperfusion injury; Resuscitation