title: Preparation, characterization, cellular response and in vivo osseointegration of polyetheretherketone/nano-hydroxyapatite/carbon fiber ternary biocomposite.
abstract: As FDA-approved implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as bioactive implant material in dental and orthopedic applications.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Peking University, Beijing 100081, China; 2nd Dental Center, School and Hospital of Stomatology, Peking University, Beijing 100081, China; Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Peking University, Beijing 100081, China; 2nd Dental Center, School and Hospital of Stomatology, Peking University, Beijing 100081, China; Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Liu
authors.affiliation: Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Peking University, Beijing 100081, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Xiong
authors.affiliation: 2nd Dental Center, School and Hospital of Stomatology, Peking University, Beijing 100081, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China. Electronic address: jiewei7860@sina.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Peking University, Beijing 100081, China; 2nd Dental Center, School and Hospital of Stomatology, Peking University, Beijing 100081, China; Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Electronic address: sc-wei@pku.edu.cn.
authors.forename: Shicheng
authors.initials: S
authors.lastname: Wei
mesh_terms: D000818:Animals; D001577:Benzophenones; D001672:Biocompatible Materials; D002244:Carbon / Q000737:chemistry*; D002454:Cell Differentiation; D002460:Cell Line; D004285:Dogs; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D007659:Ketones / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D016348:Osseointegration; D010006:Osteoblasts / Q000166:cytology; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers; D013499:Surface Properties; D055114:X-Ray Microtomography
chemical_list: D001577:Benzophenones; D001672:Biocompatible Materials; D007659:Ketones; D011108:Polymers; C063834:polyetheretherketone; D011092:Polyethylene Glycols; D002244:Carbon; D017886:Durapatite
keywords: Hydroxyapatite; Orthopedic; Osseointegration; Polyetheretherketone; Ternary composite