title: Association of NOS1AP variants and depression phenotypes in schizophrenia.
abstract: BACKGROUND
  The nitric oxide synthase 1 adaptor protein gene (NOS1AP) has previously been recognised as a schizophrenia susceptibility gene due to its role in glutamate neurotransmission. The gene is believed to inhibit nitric oxide (NO) production activated by the N-methyl-d-aspartate (NMDA) receptor and reduced NO levels have been observed in schizophrenia patients. However, association studies investigating NOS1AP and schizophrenia have produced inconsistent results, most likely because schizophrenia is a clinically heterogeneous disorder. This study aims to investigate the association between NOS1AP variants and defined depression phenotypes of schizophrenia.
  
  
  METHODS
  Nine NOS1AP SNPs, rs1415259, rs1415263, rs1858232, rs386231, rs4531275, rs4656355, rs4657178, rs6683968 and rs6704393 were genotyped in 235 schizophrenia subjects screened for various phenotypes of depression.
  
  
  RESULTS
  One NOS1AP SNP (rs1858232) was associated with the broad diagnosis of schizophrenia and eight SNPs were associated with depression related phenotypes within schizophrenia. The rs1415259 SNP showed strong association with sleep dysregulation phenotypes of depression.
  
  
  CONCLUSIONS
  Results suggest that NOS1AP variants are associated with various forms of depression in schizophrenia and are more prevalent in males.
  
  
  CONCLUSIONS
  Schizophrenia is a clinically heterogeneous disease that can vary greatly between different ethnic and geographic populations so our observations should be viewed with caution until they are independently replicated, particularly in larger patient cohorts.
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Queensland 4059, Australia.
authors.forename: Sern-Yih
authors.initials: SY
authors.lastname: Cheah
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Queensland 4059, Australia; Discipline of Psychiatry, Royal Brisbane and Women's Hospital, Herston, Queensland 4006, Australia.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Lawford
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Queensland 4059, Australia.
authors.forename: Ross McD
authors.initials: RM
authors.lastname: Young
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Queensland 4059, Australia.
authors.forename: C Phillip
authors.initials: CP
authors.lastname: Morris
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Queensland 4059, Australia. Electronic address: j.voisey@qut.edu.au.
authors.forename: Joanne
authors.initials: J
authors.lastname: Voisey
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D003863:Depression / Q000150:complications / Q000235:genetics* / Q000523:psychology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000150:complications* / Q000235:genetics*; D012565:Schizophrenic Psychology; D012727:Sex Characteristics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C488081:NOS1AP protein, human
keywords: Depression; NOS1AP; Polymorphism; Psychiatric phenotypes; SNP; Schizophrenia