title: Biokinetic analysis of tissue boron (¹⁰B) concentrations of glioma patients treated with BNCT in Finland.
abstract: A total of 98 patients with glioma were treated with BPA-F-mediated boron neutron capture therapy (BNCT) in Finland from 1999 to 2011. Thirty-nine (40%) had undergone surgery for newly diagnosed glioblastoma and 59 (60%) had malignant glioma recurrence after surgery. In this study we applied a closed 3-compartment model based on dynamic (18)F-BPA-PET studies to estimate the BPA-F concentrations in the tumor and the normal brain with time. Altogether 22 patients with recurrent glioma, treated within the context of a clinical trial, were evaluated using their individual measured whole blood (10)B concentrations as an input to the model. The delivered radiation doses to tumor and the normal brain were recalculated based on the modeled (10)B concentrations in the tissues during neutron irradiation. The model predicts from -7% to +29% (average, +11%) change in the average tumor doses as compared with the previously estimated doses, and from 17% to 61% (average, 36%) higher average normal brain doses than previously estimated due to the non-constant tumor-to-blood concentration ratios and considerably higher estimated (10)B concentrations in the brain at the time of neutron irradiation.
authors.affiliation: HUS Helsinki Medical Imaging Center, Helsinki University Hospital, Finland; Department of Physics, University of Helsinki, POB 64, FI-00014, Finland. Electronic address: hanna.koivunoro@helsinki.fi.
authors.forename: H
authors.initials: H
authors.lastname: Koivunoro
authors.affiliation: HUS Helsinki Medical Imaging Center, Helsinki University Hospital, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Hippeläinen
authors.affiliation: VTT Technical Research Centre of Finland, Espoo, Finland.
authors.forename: I
authors.initials: I
authors.lastname: Auterinen
authors.affiliation: Department of Oncology, Comprehensive Cancer Center, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Kankaanranta
authors.affiliation: Department of Neurology, Helsinki University Hospital, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Kulvik
authors.affiliation: Finnish Safety and Chemicals Agency (Tukes), Finland.
authors.forename: J
authors.initials: J
authors.lastname: Laakso
authors.affiliation: Department of Oncology, Comprehensive Cancer Center, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Seppälä
authors.affiliation: HUS Helsinki Medical Imaging Center, Helsinki University Hospital, Finland; Department of Physics, University of Helsinki, POB 64, FI-00014, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Savolainen
authors.affiliation: Department of Oncology, Comprehensive Cancer Center, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Joensuu
mesh_terms: D001895:Boron / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000532:radiotherapy*; D005387:Finland; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D011879:Radiotherapy Dosage
chemical_list: D001895:Boron
keywords: (10)B biodistribution; BNCT; BPA; Dose calculation; Glioma; PET