title: Efficacy of one- vs. two-stent implantation for coronary bifurcation lesions in diabetic patients utilizing AIR2 as an endpoint.
abstract: OBJECTIVE
  This study aimed to assess the long term outcomes (all-cause death, myocardial infarction, target vessel revascularization, and silent restenosis at 12 months) of one-stent vs. two-stent implantation due to coronary bifurcation lesionsin diabetic patients using AIR2 as a new endpoint.
  
  
  RESULTS
  A total of 178 diabetic patients with true coronary bifurcation lesions underwent percutaneous coronary intervention in the DK-Crush trials. All patients were stratified based on the stent placement strategy: one-stent group (n=76) and two-stent group (n=102). Results showed the primary endpoint, AIR2, in one-stent group was twice that in two-stent group (32.9% vs. 16.7%, P=0.013). The incidence of silent restenosis at 12 months was also significantly higher in one-stent group (19.7% versus 4.9%, P=0.003). Moreover, Kaplan-Meier analysis revealed the cumulative AIR2-free survival rate after a 12-month follow-up was markedly lower in one-stent group than in two-stent group. Interestingly, MACEs, including death, myocardial infarction and repeat revascularization, were not comparable between 2 groups (13.2% vs. 12.7%, P=0.935). Likewise, the incidence of definite or probable ST in one-stent group was also similar to that in two-stent group (2.6% vs. 4.9%, P=0.761).
  
  
  CONCLUSIONS
  Our study indicates that, in terms of the AIR2 as a combined clinical and angiographic endpoint, two-stent implantation is superior to one-stent implantation for the treatment of coronary bifurcation intervention in diabetic patients.
authors.affiliation: Laboratory of Coronary Heart Diseases, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China ; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Laboratory of Coronary Heart Diseases, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
authors.forename: Guozhen
authors.initials: G
authors.lastname: Jin
authors.affiliation: Department of Electrocardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Department of Cardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
authors.forename: Shoujie
authors.initials: S
authors.lastname: Shan
authors.affiliation: Department of Cardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.affiliation: Department of Cardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
authors.forename: Nailiang
authors.initials: N
authors.lastname: Tian
authors.affiliation: Department of Cardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
authors.forename: Jiupei
authors.initials: J
authors.lastname: Chen
authors.affiliation: Laboratory of Coronary Heart Diseases, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China ; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu Province, China.
authors.forename: Shaoliang
authors.initials: S
authors.lastname: Chen
keywords: Coronary heart disease; bifurcation lesion; diabetes; percutaneous coronary intervention