title: Alterations in lipid peroxidation and T-cell function in women with hyperemesis gravidarum.
abstract: The objective of this study was to investigate serum adenosine deaminase (ADA) activity as a marker of T lymphocyte activation and parameters of oxidative stress and antioxidant defence in hyperemesis gravidarum (HG). Serum ADA activity, malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GPx) levels were investigated in 40 pregnant women with the HG and 40 with healthy pregnancies, in a descriptive study. Although serum ADA and CAT were measured to be higher in HG group, the difference was not significant. Serum MDA and GPx levels were significantly elevated in women with HG when compared with those without HG. The significance of changes in lipid peroxidation and T-cell activation in the pathogenesis of HG and whether this is a cause or a compensatory reaction to HG requires further investigations with larger multicentre trials.
authors.affiliation: a Dr. Zekai Tahir Burak Women Health Care, Education and Research Hospital, Department of Perinatology , Ankara , Turkey.
authors.forename: E H
authors.initials: EH
authors.lastname: Biberoglu
authors.affiliation: a Dr. Zekai Tahir Burak Women Health Care, Education and Research Hospital, Department of Perinatology , Ankara , Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kirbas
authors.affiliation: a Dr. Zekai Tahir Burak Women Health Care, Education and Research Hospital, Department of Perinatology , Ankara , Turkey.
authors.forename: A Ö
authors.initials: AÖ
authors.lastname: Dirican
authors.affiliation: b Ankara University Faculty of Medicine, Department of Biochemistry , Ankara , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Genc
authors.affiliation: b Ankara University Faculty of Medicine, Department of Biochemistry , Ankara , Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Avci
authors.affiliation: c Ankara University Faculty of Medicine, Department of Biostatistics , Ankara , Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Doganay
authors.affiliation: a Dr. Zekai Tahir Burak Women Health Care, Education and Research Hospital, Department of Perinatology , Ankara , Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Uygur
authors.affiliation: d Gazi University Faculty of Medicine, Department of Obstetrics and Gynecology , Ankara , Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Biberoglu
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood; D000328:Adult; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000503:physiopathology*; D015227:Lipid Peroxidation; D008213:Lymphocyte Activation; D008315:Malondialdehyde / Q000097:blood; D011247:Pregnancy; D013601:T-Lymphocytes / Q000502:physiology*; D055815:Young Adult
chemical_list: D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D000243:Adenosine Deaminase
keywords: Adenosine deaminase; catalase; glutathione peroxidase; hyperemesis gravidarum; malondialdehyde