title: Cerebral proliferative angiopathy with papilledema.
abstract: A young female presented with intermittent blurring of vision and mild to moderate headache for three months. Fundus examination revealed bilateral papilledema with secondary optic atrophy (right more than left). Computed tomography scan of brain showed a diffuse intraparenchymal vascular malformation in right parietooccipital region. Cerebral digital subtraction angiography (DSA) revealed diffuse nidus in right parietooccipital area, supplied by multiple branches of distal middle cerebral artery and anterior cerebral artery. Scattered-puddling appearance of contrast was noted in diffuse nidus and there were no definite arterial feeders. DSA was consistent with the diagnosis of cerebral proliferative angiopathy (CPA). The patient was started on acetazolamide 250 mg twice a day. At six months follow up, she was asymptomatic with resolving papilledema. CPA is a rare vascular malformation, any case report that gives further insight to it will be very useful to the scientific community. Herein, we describe an unusual association of CPA with papilledema.
authors.affiliation: Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India. Electronic address: doc.kumarsunil@hotmail.com.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India. Electronic address: trilochan_9@yahoo.co.in.
authors.forename: Trilochan
authors.initials: T
authors.lastname: Srivastava
authors.affiliation: Department of Radiology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India. Electronic address: s.tejwani2013@gmail.com.
authors.forename: Shankar
authors.initials: S
authors.lastname: Tejwani
authors.affiliation: Department of Ophthalmology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India. Electronic address: khilnanikamlesh@gmail.com.
authors.forename: Kamlesh
authors.initials: K
authors.lastname: Khilnani
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use; D015901:Angiography, Digital Subtraction; D020771:Anterior Cerebral Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging; D002533:Cerebral Angiography; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005654:Fundus Oculi; D006261:Headache / Q000209:etiology; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D010211:Papilledema / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D020769:Posterior Cerebral Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging; D054063:Superior Sagittal Sinus / Q000002:abnormalities* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D004232:Diuretics; D000086:Acetazolamide
keywords: Arteriovenous malformations; Cerebral proliferative angiopathy; Papilledema