title: Characterisation of Yersinia Secretion Apparatus--Pathogenicity Island (Ysa-PI) of Yersinia enterocolitica 1B/O8 in Poland: an Idle Ysa is a Specific Hallmark of the Epidemic Sensu Stricto Strain.
abstract: Yersinia secretion apparatus (Ysa), the chromosomal type three secretion system (T3SS) is considered to contribute to virulence of high-pathogenicity Yersina enterocolitica biovar 1B. DNA-sequence of Ysa pathogenicity island was determined for clinical isolate DM0110 of Y enterocolitica 1B/08 with origin in Poland. We found a premature stop-codon in the regulatory gene ysrR (mutation at position 269). Altered ysrR was detected in all tested 78 isolates of Y enterocolitica 1B/O8 collected from clinical samples in Poland from 2004 to 2013. Since aberrations in YsrR are considered to inactivate Ysa, our findings may suggest Ysa is not indispensable for Y enterocolitica 1B/O8 to infect humans.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wołkowicz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Zacharczuk
authors.forename: Natalia
authors.initials: N
authors.lastname: Rokosz-Chudziak
authors.forename: Waldemar
authors.initials: W
authors.lastname: Rastawicki
authors.forename: Rafał
authors.initials: R
authors.lastname: Gierczyński
mesh_terms: D044404:Genomic Islands / Q000235:genetics*; D006801:Humans; D011044:Poland / Q000453:epidemiology; D015009:Yersinia Infections / Q000453:epidemiology / Q000382:microbiology*; D015008:Yersinia enterocolitica / Q000145:classification / Q000502:physiology*