title: STAT5 gene polymorphisms are associated with the response of acute myeloid leukemia patients to Ara-C-based chemotherapy.
abstract: The constitutive activation of signal transducer and activator of transcription 5 (STAT5) occurs during the transformation of fusion genes in leukemia. We aimed to investigate whether or not the genetic polymorphisms in the STAT5 gene are associated with the treatment outcomes of Ara-C-based chemotherapy regimens in patients with acute myeloid leukemia (AML). A total of 152 patients with AML were included in our study. Peripheral blood samples were analyzed through matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Results showed that the frequency of rs2293157 T/T was higher in the complete remission and partial remission groups after Ara-C-based chemotherapy even though the genotype had a high frequency in the intermediate risk groups (p < 0.05). We concluded that rs2293157 is an important marker for the therapeutic efficiency of Ara-C-based chemotherapy in patients with AML, especially in the Chinese population.
authors.affiliation: a Department of Hematology , The Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing , People's Republic of China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Xu
authors.affiliation: a Department of Hematology , The Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing , People's Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhou
authors.affiliation: a Department of Hematology , The Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing , People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ouyang
authors.affiliation: a Department of Hematology , The Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing , People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D005838:Genotype; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D050799:STAT5 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D016896:Treatment Outcome
chemical_list: D050799:STAT5 Transcription Factor; D003561:Cytarabine
keywords: Acute myeloid leukemia; STAT5; chemotherapy; polymorphism