title: Association of Meloxicam Use with the Risk of Acute Pancreatitis: A Case-Control Study.
abstract: OBJECTIVE
  No sufficient research has focused on the relationship between meloxicam use and acute pancreatitis. This study aimed to explore this issue in Taiwan.
  
  
  METHODS
  This case-control study was conducted using the database of the Taiwan National Health Insurance Program. In all, there were 6780 cases aged 20-84 years who were newly diagnosed with acute pancreatitis during the period 1998-2011, and 21,393 control subjects without acute pancreatitis. Cases and controls were matched for sex, age and comorbidities. Odds ratios (ORs) and 95% confidence intervals (CIs) were measured to explore the associations between acute pancreatitis, meloxicam use and comorbidities, using a multivariable unconditional logistic regression model.
  
  
  RESULTS
  After controlling for potential confounding factors, the adjusted OR for acute pancreatitis was 1.76 (95% CI 1.30-2.40) for subjects with current use of meloxicam, in comparison with subjects who had never used meloxicam. The adjusted OR decreased to 1.29 (95% CI 0.82-2.03) for subjects with late use of meloxicam, but without statistical significance.
  
  
  CONCLUSIONS
  Current use of meloxicam is associated with increased odds of acute pancreatitis. Clinicians should consider the potential risk of acute pancreatitis when prescribing meloxicam.
authors.affiliation: College of Medicine, China Medical University, Taichung City, Taiwan. wei@mail.cmuh.org.tw.|Department of Family Medicine, China Medical University Hospital, Taichung City, Taiwan. wei@mail.cmuh.org.tw.
authors.forename: Shih-Wei
authors.initials: SW
authors.lastname: Lai
authors.affiliation: College of Medicine, China Medical University, Taichung City, Taiwan. orangechengli@gmail.com.|Management Office for Health Data, China Medical University Hospital, Taichung City, Taiwan. orangechengli@gmail.com.
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.affiliation: College of Medicine, Tzu Chi University, Hualien City, Taiwan. kuanfuliaog@gmail.com.|Department of Internal Medicine, Taichung Tzu Chi General Hospital, No. 66, Sec. 1, Fongsing Road, Tanzi District, Taichung City, 427, Taiwan. kuanfuliaog@gmail.com.|Graduate Institute of Integrated Medicine, China Medical University, Taichung City, Taiwan. kuanfuliaog@gmail.com.
authors.forename: Kuan-Fu
authors.initials: KF
authors.lastname: Liao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019973:Alcohol-Related Disorders / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D016208:Databases, Factual; D005260:Female; D042882:Gallstones / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D008297:Male; D000077239:Meloxicam; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced / Q000453:epidemiology*; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D013843:Thiazines / Q000009:adverse effects*; D013844:Thiazoles / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam