title: A Comparison of Antibiotic Serum Concentrations Drawn Simultaneously from Peripherally Inserted Central Catheters and Peripheral Veins in Children with Respiratory Infection.
abstract: The purpose of the study was to evaluate serum concentration of antibiotics drawn from a peripherally inserted central catheter (PICC) compared with a peripheral venipuncture. This prospective comparative study included patients with ages 1month to 21years admitted with a respiratory infection requiring IV vancomycin or IV tobramycin via a newly placed PICC. The difference between the antibiotic levels from the venipuncture and PICC samples was statistically significant for both the peak and trough levels. However, the difference in values was not enough to impact antibiotic dosing and therefore was not clinically significant.
authors.affiliation: Boston Children's Hospital, Boston, MA. Electronic address: MaryEllen.Green@childrens.harvard.edu.
authors.forename: Mary Ellen
authors.initials: ME
authors.lastname: Green
authors.affiliation: Boston Children's Hospital, Boston, MA.
authors.forename: Keri J
authors.initials: KJ
authors.lastname: Sullivan
authors.affiliation: Boston Children's Hospital, Boston, MA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Wells
authors.affiliation: Northeastern University, Boston, MA.
authors.forename: Rhonda
authors.initials: R
authors.lastname: Board
authors.affiliation: Clinical Research Center, Boston Children's Hospital, Boston, MA.
authors.forename: Henry A
authors.initials: HA
authors.lastname: Feldman
authors.affiliation: Boston Children's Hospital, Boston, MA.
authors.forename: Margaret
authors.initials: M
authors.lastname: McCabe
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood*; D002405:Catheterization, Central Venous / Q000379:methods*; D002406:Catheterization, Peripheral / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D006776:Hospitals, Pediatric; D006801:Humans; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000188:drug therapy*; D012680:Sensitivity and Specificity; D014031:Tobramycin / Q000008:administration & dosage / Q000097:blood; D014640:Vancomycin / Q000008:administration & dosage / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D014031:Tobramycin
keywords: Antibiotic levels; CVC; Cystic fibrosis; PICC; Respiratory illness; Tobramycin; Vancomycin; Venipunctures