title: Identifying therapeutic targets in gastric cancer: the current status and future direction.
abstract: Gastric cancer is the third leading cause of cancer-related death worldwide. Our basic understanding of gastric cancer biology falls behind that of many other cancer types. Current standard treatment options for gastric cancer have not changed for the last 20 years. Thus, there is an urgent need to establish novel strategies to treat this deadly cancer. Successful clinical trials with Gleevec in CML and gastrointestinal stromal tumors have set up an example for targeted therapy of cancer. In this review, we will summarize major progress in classification, therapeutic options of gastric cancer. We will also discuss molecular mechanisms for drug resistance in gastric cancer. In addition, we will attempt to propose potential future directions in gastric cancer biology and drug targets.
authors.affiliation: Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Departments of Pediatrics, Biochemistry and Molecular Biology, Pharmacology and Toxicology, The Wells Center for Pediatrics Research, Indianapolis, IN 46202, USA.
authors.forename: Beiqin
authors.initials: B
authors.lastname: Yu
authors.affiliation: Departments of Pediatrics, Biochemistry and Molecular Biology, Pharmacology and Toxicology, The Wells Center for Pediatrics Research, Indianapolis, IN 46202, USA jinxie@iu.edu.
authors.forename: Jingwu
authors.initials: J
authors.lastname: Xie
mesh_terms: D000818:Animals; D017209:Apoptosis; D002986:Clinical Trials as Topic; D004249:DNA Damage; D019008:Drug Resistance, Neoplasm; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D008495:Medical Oncology / Q000639:trends; D051379:Mice; D014411:Neoplastic Stem Cells / Q000378:metabolism; D010641:Phenotype; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D059016:Tumor Microenvironment
chemical_list: D019869:Phosphatidylinositol 3-Kinases
keywords: Wnt; cancer stem cell; gastric cancer; hedgehog; targeted therapy