title: Comparison between follicular stimulation and luteal stimulation protocols with clomiphene and HMG in women with poor ovarian response.
abstract: This retrospective study is to compare the follicular mild stimulation and luteal simulation protocols for poor responders undergoing in vitro fertilization (IVF). A total of 131 women were diagnosed as poor responders. Thirty-three women started ovarian stimulation in early-luteal phase and 98 women started in early follicular phase with 100 mg/d clomiphene citrate and 75-150 IU/d HMG. There were more oocytes retrieved (2.8 ± 2.0 versus 2.0 ± 1.2, p < 0.05), more available embryos (1.8 ± 1.4 versus 1.3 ± 1.1, p < 0.05) and top-quality embryos (0.9 ± 0.9 versus 0.4 ± 0.6, p < 0.05), and reduced cycle cancellation rate (12.1% versus 30.6%, p < 0.05) in luteal group than in follicular group. The clinical pregnancy (17.7%, 20.0% and 41.2%) and live-birth rates (10.78%, 20.0% and 29.4%) after transferring embryos obtained from luteal, follicular and mixed stages were comparable (p > 0.05). For poor responders, luteal phase stimulation could be an option because of increasing the chance to obtain competent embryos and reducing the cycle cancellation rate.
authors.affiliation: a The Department of Obstetrics and Gynecology , Reproductive Medicine Centre, Sun Yat-sen Memorial Hospital of Sun Yat-Sen University , Guangzhou , China .
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: b The Department of Obstetrics and Gynecology , Reproductive Medicine Center, The Third Affiliated Hospital of Beijing University , Beijing , China.
authors.forename: Wan
authors.initials: W
authors.lastname: Yang
authors.affiliation: a The Department of Obstetrics and Gynecology , Reproductive Medicine Centre, Sun Yat-sen Memorial Hospital of Sun Yat-Sen University , Guangzhou , China .
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Chen
authors.affiliation: a The Department of Obstetrics and Gynecology , Reproductive Medicine Centre, Sun Yat-sen Memorial Hospital of Sun Yat-Sen University , Guangzhou , China .
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: a The Department of Obstetrics and Gynecology , Reproductive Medicine Centre, Sun Yat-sen Memorial Hospital of Sun Yat-Sen University , Guangzhou , China .
authors.forename: Qingxue
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: a The Department of Obstetrics and Gynecology , Reproductive Medicine Centre, Sun Yat-sen Memorial Hospital of Sun Yat-Sen University , Guangzhou , China .
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000328:Adult; D002985:Clinical Protocols; D002996:Clomiphene / Q000627:therapeutic use*; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro / Q000379:methods; D005498:Follicular Phase; D006801:Humans; D008183:Luteal Phase; D008596:Menotropins / Q000627:therapeutic use*; D009865:Oocytes; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene; D008596:Menotropins
keywords: Assisted reproductive technology; in vitro fertilization; luteal phase; ovarian stimulation; poor ovarian response