title: Clinical Utilization of Repeated Open Application Test Among American Contact Dermatitis Society Members.
abstract: BACKGROUND
  The repeated open application test (ROAT) provides useful information regarding allergens in suspected cases of allergic contact dermatitis; however, standardized methodology has not been established.
  
  
  OBJECTIVE
  The aim of this study was to assess how ROAT is used in clinical and research settings.
  
  
  METHODS
  We distributed a survey regarding ROAT practice to the American Contact Dermatitis Society and conducted a literature review of ROAT utilization in research.
  
  
  RESULTS
  A total of 67 American Contact Dermatitis Society members participated in the survey. Respondents most frequently recommend application of leave-on products twice daily (46.0%) and rinse-off products once daily (43.5%). The most commonly used anatomical sites include the forearm (38.7%) and antecubital fossa (32.3%). Most respondents continue ROAT for 1 (49.2%) or 2 weeks (31.7%). Literature review of 32 studies (26 leave-on, 6 rinse-off) revealed that application frequency is most common at twice daily for both leave-on (96.2%) and rinse-off (50.0%) products. The most common anatomical site is the forearm (62.5%), with an overall study duration of 3 to 4 weeks (65.6%).
  
  
  CONCLUSIONS
  When comparing ROAT clinical and research practice, the majority trend was consistent for leave-on product application frequency and anatomical site, but not for rinse-off product application frequency, or overall duration. Further research is needed to determine best practice recommendations.
authors.affiliation: From the *College of Medicine, University of Arizona, Tucson; †Department of Dermatology, University of California, San Francisco; ‡Department of Medicine, University of Arizona, Tucson; and §Palo Alto Foundation Medical Group, Mountain View, CA.
authors.forename: Gabrielle E
authors.initials: GE
authors.lastname: Brown
authors.forename: Nina
authors.initials: N
authors.lastname: Botto
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Butler
authors.forename: Jenny E
authors.initials: JE
authors.lastname: Murase
mesh_terms: D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D003880:Dermatology; D006801:Humans; D010328:Patch Tests; D010818:Practice Patterns, Physicians'; D012882:Skin Tests / Q000379:methods / Q000706:statistics & numerical data; D012955:Societies, Medical; D011795:Surveys and Questionnaires