title: Redox control of protein degradation.
abstract: Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy and the unfolded protein response (UPR). In the presence of an oxidant environment, these systems are critical to ensure proteostasis and cell survival. An example of altered degradation of oxidized proteins in pathology is provided for neurodegenerative diseases. Future work will determine if protein oxidation is a valid target to combat proteinopathies.
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, Spain; Instituto de Investigación Sanitaria La Paz (IdiPAZ), 28029 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Pajares
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, Spain; Instituto de Investigación Sanitaria La Paz (IdiPAZ), 28029 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Jiménez-Moreno
authors.affiliation: Aston Research Centre for Healthy Ageing, Life and Health Sciences and, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
authors.forename: Irundika H K
authors.initials: IHK
authors.lastname: Dias
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey.
authors.forename: Bilge
authors.initials: B
authors.lastname: Debelec
authors.affiliation: Department of Physiology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, 11060 Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Vucetic
authors.affiliation: Department of Molecular Biology, University of Bergen, Bergen N-5020, Norway.
authors.forename: Kari E
authors.initials: KE
authors.lastname: Fladmark
authors.affiliation: Molecular Biology Genetics and Bioengineering Preogram, Sabanci University, 34956 Tuzla, Istanbul, Turkey.
authors.forename: Huveyda
authors.initials: H
authors.lastname: Basaga
authors.affiliation: University of Ljubljana, Faculty of Medicine, Inst. of Pathophysiology, Zaloska 4, SI-1000 Ljubljana, Slovenia.
authors.forename: Samo
authors.initials: S
authors.lastname: Ribaric
authors.affiliation: University of Ljubljana, Faculty of Medicine, Inst. of Pathophysiology, Zaloska 4, SI-1000 Ljubljana, Slovenia; Laboratory of Oxidative Stress Research, Faculty of Health Sciences, Zdravstvena pot 5, SI-1000 Ljubljana, Slovenia.
authors.forename: Irina
authors.initials: I
authors.lastname: Milisav
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, Spain; Instituto de Investigación Sanitaria La Paz (IdiPAZ), 28029 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Spain. Electronic address: antonio.cuadrado@uam.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cuadrado
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D001343:Autophagy / Q000235:genetics; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D017096:Prion Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D059748:Proteolysis; D017382:Reactive Oxygen Species / Q000378:metabolism*; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism; D054875:Ubiquitination; D056811:Unfolded Protein Response / Q000235:genetics
chemical_list: D009419:Nerve Tissue Proteins; D017382:Reactive Oxygen Species; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex
keywords: Autophagy; Proteasome; Protein oxidation; Proteolysis; Unfolded protein response