title: Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents.
abstract: In the present study, some 9-aminoacridine derivatives have been synthesized by condensation of 9-aminoacridine with substituted phenacyl, benzoyl, and benzyl halides (RM1-RM6). Compounds were investigated for acetylcholinesterase and butyrylcholinesterase inhibition potential, considering these enzymes playing a key role in Alzheimer's disease. All derivatives showed better inhibition of enzymes than the standard galantamine, whereas except RM4, all exhibit better results than tacrine, a well-known acridine derivative used for the treatment of Alzheimer's disease.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan pharmacistrabya@gmail.com.
authors.forename: Rabya
authors.initials: R
authors.lastname: Munawar
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Nousheen
authors.initials: N
authors.lastname: Mushtaq
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Sadia
authors.initials: S
authors.lastname: Arif
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Ahsaan
authors.initials: A
authors.lastname: Ahmed
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Shamim
authors.initials: S
authors.lastname: Akhtar
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Sumaira
authors.initials: S
authors.lastname: Ansari
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Sadia
authors.initials: S
authors.lastname: Meer
authors.affiliation: HEJ Research Institute of Chemical Sciences (ICCBS), University of Karachi, Karachi, Pakistan.
authors.forename: Zafar S
authors.initials: ZS
authors.lastname: Saify
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Arif
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology*; D000585:Aminacrine / Q000138:chemical synthesis*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis*; D006801:Humans; D066298:In Vitro Techniques
chemical_list: D002800:Cholinesterase Inhibitors; D000585:Aminacrine
keywords: 9-aminoacridine (9AA); Alzheimer; acetylcholinesterase (AChE); butyrylcholinesterase (BuChE); cholinesterases (ChE); tacrine