title: [Cardiac fibroma: A rare cause of sudden child death].
abstract: We report the case of a 3-year-old child who died from the consequences of a cardio-respiratory arrest despite reanimation procedures. Echocardiography and magnetic resonance imaging (MRI) revealed a mass of the free wall of the left ventricle. Autopsy confirmed the existence of a solitary myocardial tumor, well-circumscribed, firm, with a whitish and trabeculated cut surface. Histologically, the tumor consisted of bundles of spindle-shaped and regular cells mingling with collagen and elastic fibers, insinuating themselves between myocytes in periphery. Calcifications were present. After immunohistochemistry, the cells were highlighted by anti-actin smooth muscle antibody; but they were not highlighted by anti-desmin, anti-β catenin and anti-Ki67 antibodies. The diagnosis of cardiac fibroma was made. The primary cardiac tumors of child are rare and usually benign. They are essentially represented by rhabdomyoma and fibroma. Cardiac fibroma mostly occurs during the first year of life. It can be revealed by cardiac insufficiency, arrhythmia, chest pain or sudden death.
authors.affiliation: Centre de biologie pathologie génétique, institut de pathologie, CHRU de Lille, avenue Oscar-Lambret, CS 70001, 59037 Lille cedex, France; Faculté de médecine Henri-Warembourg, université de Lille 2, 59000 Lille, France. Electronic address: sarah.humez@chru-lille.fr.
authors.forename: Sarah
authors.initials: S
authors.lastname: Humez
authors.affiliation: Centre de biologie pathologie génétique, institut de pathologie, CHRU de Lille, avenue Oscar-Lambret, CS 70001, 59037 Lille cedex, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Gibier
authors.affiliation: Service de cardiologie pédiatrique, hôpital cardiologique, CHRU de Lille, avenue Oscar-Lambret, 59037 Lille, France; Faculté de médecine Henri-Warembourg, université de Lille 2, 59000 Lille, France.
authors.forename: Morgan
authors.initials: M
authors.lastname: Recher
authors.affiliation: Service de réanimation pédiatrique, hôpital Jeanne-de-Flandre, CHRU de Lille, avenue Eugène-Avinée, 59037 Lille, France; Faculté de médecine Henri-Warembourg, université de Lille 2, 59000 Lille, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Leteurtre
authors.affiliation: Centre de biologie pathologie génétique, institut de pathologie, CHRU de Lille, avenue Oscar-Lambret, CS 70001, 59037 Lille cedex, France; Faculté de médecine Henri-Warembourg, université de Lille 2, 59000 Lille, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.affiliation: Centre de biologie pathologie génétique, institut de pathologie, CHRU de Lille, avenue Oscar-Lambret, CS 70001, 59037 Lille cedex, France.
authors.forename: Louise
authors.initials: L
authors.lastname: Devisme
mesh_terms: D002114:Calcinosis / Q000473:pathology; D006332:Cardiomegaly / Q000209:etiology; D002675:Child, Preschool; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D003937:Diagnosis, Differential; D005350:Fibroma / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D006338:Heart Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D012207:Rhabdomyoma / Q000175:diagnosis
keywords: Cardiac tumor; Fibroma; Fibrome; Mort subite de l’enfant; Sudden child death; Tumeur cardiaque