title: Prevalence of cardiovascular disease risk factors, and metabolic syndrome and its components in patients with psoriasis aged 30 to 49 years.
abstract: BACKGROUND
  Some studies show that metabolic syndrome (MS) is more common in psoriatic patients.
  
  
  OBJECTIVE
  To evaluate the prevalence of MS and its components as cardiovascular disease (CVD) risk factors in psoriatic patients compared to the general Polish population.
  
  
  METHODS
  In 62 patients, aged 30 to 49 years with a mild to severe course of psoriasis, the features of MS have been assessed by IDF definition and compared to the results obtained in the NATPOL 2011 study.
  
  
  RESULTS
  Analysis of CVD risk factors in patients with a severe course of psoriasis showed a correlation with waist circumference (0.38, p < 0.05), hypertension (0.40, p < 0.05) and a negative correlation with HDL (0.29, p < 0.05). The prevalence of MS in psoriatic patients was 25.81%, and for the control group - 21.02% (p > 0.05), the mean HOMA-IR was 1.93 and 1.94 (p > 0.05), respectively. There were differences in the prevalence of abdominal obesity (53.6% vs. 40.3%, p < 0.05). In lipid parameters, except for HDL, the compared groups did not differ significantly (triglycerides, ApoA-I and B). Criteria for MS concerning blood pressure (> 130/85 mm Hg) and hypertension were more frequent in men with psoriasis than in the control group (38.2% vs. 11.1%, p < 0.05).
  
  
  CONCLUSIONS
  Severe psoriasis is associated with a significantly higher prevalence of risk factors for CVD. The prevalence of MS, insulin resistance and lipid abnormalities in patients with psoriasis aged 30 to 49 years is similar to the general Polish population. Abdominal obesity is more common in psoriatic patients and hypertension in men with psoriasis.
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland. Head of the Department: Prof. Waldemar Placek MD, PhD.
authors.forename: Agnieszka B
authors.initials: AB
authors.lastname: Owczarczyk-Saczonek
authors.affiliation: Department of Dermatology, Venereology and Allergology, Gdansk Medical University, Gdansk, Poland. Head of the Department: Prof. Roman Nowicki MD, PhD.
authors.forename: Roman J
authors.initials: RJ
authors.lastname: Nowicki
keywords: cardiovascular risk factors; metabolic syndrome; psoriasis