title: Risk factors for cardiovascular disease in rheumatoid arthritis patients from Mato Grosso do Sul.
abstract: OBJECTIVE
  To identify risk factors for cardiovascular disease in patients with Rheumatoid Arthritis (RA).
  
  
  METHODS
  A descriptive cross-sectional study with 71 patients with established RA. The instruments used were: DAS-28, HAQ and SF-36, and the following parameters were determined: the erythrocyte sedimentation rate, capillary blood glucose; total cholesterol (TC) and its fractions, thyroid hormones, antinuclear antibodies (ANA), rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPAs). Patients were classified into groups HAQ ≤ 1 (mild dysfunction) and HAQ > 1 (moderate and severe dysfunction) and, according to the HAQ scores, in groups treated with corticosteroids (CS) and without CS.
  
  
  RESULTS
  9 patients were male and 62 female with mean age and duration of disease of 53.45 (± 10.7) and 9.9 (± 8.6), respectively. RF was positive in 52 (76%), ACPAs in 54 (76.1%) and ANA in 12 (16.9%). Thirty-six patients (50.7%) had systemic hypertension, 9 (12.68%) diabetes mellitus, 16 (22.5%) hypothyroidism, 33 (46.5%) dyslipidemia and 8 (11.27%) were smokers. The results of TC >240 were found in 53.8% for group HAQ >1 (26) and in 24.4% for group HAQ ≤ 1 (45) (p=0.020). These groups did not differ as to presence of comorbidities or drug treatment. Triglyceride levels >200 for the group with CS (42.4%) versus without CS (18.42%) were significant (p=0.025).
  
  
  CONCLUSIONS
  An association of increased TC and triglycerides with results of HAQ ≤ 1 and with CS use was noted, reinforcing the importance of screening risk factors associated with cardiovascular disease in RA.
authors.affiliation: Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brasil. Electronic address: ramaojunior@ufgd.edu.br.
authors.forename: Ramão Souza
authors.initials: RS
authors.lastname: de Deus Junior
authors.affiliation: Hospital Universitário de Dourados, Universidade Federal da Grande Dourados, Dourados, MS, Brasil.
authors.forename: Andressa Leite
authors.initials: AL
authors.lastname: Ferraz
authors.affiliation: Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brasil; Universidad de León, León, Espanha.
authors.forename: Silvia Aparecida
authors.initials: SA
authors.lastname: Oesterreich
authors.affiliation: Hospital Universitário de Dourados, Universidade Federal da Grande Dourados, Dourados, MS, Brasil; Universidade Estadual de Londrina, Londrina, PR, Brasil.
authors.forename: Wanderlei Onofre
authors.initials: WO
authors.lastname: Schmitz
authors.affiliation: Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brasil; Hospital Universitário de Dourados, Universidade Federal da Grande Dourados, Dourados, MS, Brasil; Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Marcia Midori
authors.initials: MM
authors.lastname: Shinzato
mesh_terms: D000075422:Anti-Citrullinated Protein Antibodies / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications*; D001786:Blood Glucose / Q000032:analysis; D001799:Blood Sedimentation; D001938:Brazil; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000097:blood; D012307:Risk Factors
chemical_list: D000075422:Anti-Citrullinated Protein Antibodies; D001786:Blood Glucose; D012217:Rheumatoid Factor; D002784:Cholesterol
keywords: Artrite reumatoide; Autoantibodies; Autoanticorpos; Comorbidades; Comorbidities; Rheumatoid arthritis