title: Stereochemical analysis of glycerophospholipids by vibrational circular dichroism.
abstract: The stereochemistry of glycerophospholipids (GPLs) has been of interest for its roles in the evolution of life and in their biological activity. However, because of their structural complexity, no convenient method to determine their configuration has been reported. In this work, through the first systematic application of vibrational circular dichroism (VCD) spectroscopy to various diacylated GPLs, we have revealed that their chirality can be assigned by the sign of a VCD exciton couplet generated by the interaction of two carbonyl groups. This paper also presents spectroscopic evidence for the stereochemistry of GPLs isolated from bacteria, eukaryotes, and mitochondria.
authors.affiliation: Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University , Kita 21 Nishi 11, Sapporo 001-0021, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Taniguchi
authors.affiliation: Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University , Kita 21 Nishi 11, Sapporo 001-0021, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Manai
authors.affiliation: Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University , Kita 21 Nishi 11, Sapporo 001-0021, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Shibata
authors.affiliation: Graduate School of Fisheries Sciences, Hokkaido University , Hakodate 041-8611, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Itabashi
authors.affiliation: Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University , Kita 21 Nishi 11, Sapporo 001-0021, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Monde
mesh_terms: D002942:Circular Dichroism; D020404:Glycerophospholipids / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D014732:Vibration
chemical_list: D020404:Glycerophospholipids