title: Acute Fatty Liver of Pregnancy and its Differentiation from Other Liver Diseases in Pregnancy.
abstract: Background:There are a number of threatening liver diseases that occur during pregnancy. Acute fatty liver of pregnancy is a rare disease associated with high maternal and foetal mortality.Case Report:We report on a young gravida 1 woman who presented to our level 1 perinatal centre in the 36 + 5 week of pregnancy with an isolated elevation of transaminases together with diffuse upper abdominal complaints. After comprehensive diagnostic work-up we performed an emergency delivery by Caesarean section. This was followed by interdisciplinary management.Discussion:The differentiation from other liver diseases seems not to be obvious in all cases. Here we consider the following differential diagnoses: hyperemesis gravidarum, intrahepatic gestational cholestasis, preeclampsia, HELLP syndrome.Conclusion:Rapid diagnosis and delivery as well as interdisciplinary aftercare are necessary in order to reduce maternal and foetal mortality.
authors.affiliation: Abteilung für Gynäkologie und Geburtshilfe, Vivantes Klinikum im Friedrichshain, Berlin.
authors.forename: J T
authors.initials: JT
authors.lastname: Maier
authors.affiliation: Abteilung für Gynäkologie und Geburtshilfe, Vivantes Klinikum im Friedrichshain, Berlin.
authors.forename: E
authors.initials: E
authors.lastname: Schalinski
authors.affiliation: Abteilung für Gynäkologie und Geburtshilfe, Vivantes Klinikum im Friedrichshain, Berlin.
authors.forename: C
authors.initials: C
authors.lastname: Häberlein
authors.affiliation: Abteilung für Gastroenterologie, Vivantes Klinikum im Friedrichshain, Berlin.
authors.forename: U
authors.initials: U
authors.lastname: Gottschalk
authors.affiliation: Abteilung für Gynäkologie und Geburtshilfe, Vivantes Klinikum im Friedrichshain, Berlin.
authors.forename: L
authors.initials: L
authors.lastname: Hellmeyer
keywords: HELLP syndrome; acute fatty liver of pregnancy; disseminated intravascular coagulation; high-risk pregnancy; maternal mortality; premature birth