title: The prognostic value of admission mean platelet volume to platelet count ratio in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
abstract: BACKGROUND
  Mean platelet volume to platelet count (MPV/Plt) ratio has been demonstrated to be a good indicator of long-term mortality in patients with non-ST-segment elevation myocardial infarction (NSTEMI). However, the prognostic value of MPV/Plt in ST-elevation myocardial infarction (STEMI) is not reported.
  
  
  OBJECTIVE
  To determine whether the MPV/Plt ratio on admission has any predictive value for major adverse cardiac events including short- and long-term mortality in STEMI.
  
  
  METHODS
  In this prospective study, 470 STEMI patients who underwent primary percutaneous coronary intervention (PCI) were enrolled. The patients were divided into three tertiles based on the MPV/Plt ratio on admission. The first tertile (n = 149) was defined as MPV/Plt ratio ≤ 0.029, second tertile (n = 154) 0.029-0.038, and third tertile (n = 159) ≥ 0.038. Primary clinical outcomes consisted of the sum of cardiovascular (CV) mortality, non-fatal re-infarction, and stroke. Secondary clinical outcomes were CV mortality, non-fatal re-infarction, target-vessel revascularisation, stroke, and advanced heart failure.
  
  
  RESULTS
  There was no difference between study groups regarding the primary (p > 0.05) and the secondary outcomes (p > 0.05) except for one-year non-fatal re-infarction rate, which was found to be significantly higher in the highest MPV/Plt ratio group (p = 0.045). Age, Killip class > 1, and left ventricular ejection fraction were found to be independent predictors of long-term CV mortality in multivariate analysis (p = 0.009, p = 0.035, and p < 0.001, respectively).
  
  
  CONCLUSIONS
  While the MPV/Plt ratio was demonstrated to be associated with one-year non-fatal re-infarction, it was not related to in-hospital, one-month, and one-year CV mortality in patients with STEMI, who underwent primary PCI.
authors.forename: Ismail
authors.initials: I
authors.lastname: Bolat
authors.forename: Ozgur
authors.initials: O
authors.lastname: Akgul
authors.affiliation: Rize Kackar Government Hospital, Department of Cardiology, Rize,. altugcakmak@hotmail.com.
authors.forename: Huseyin Altug
authors.initials: HA
authors.lastname: Cakmak
authors.forename: Hamdi
authors.initials: H
authors.lastname: Pusuroglu
authors.forename: Umut
authors.initials: U
authors.lastname: Somuncu
authors.forename: Sinem
authors.initials: S
authors.lastname: Ozbey
authors.forename: Vesile
authors.initials: V
authors.lastname: Ornek
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erturk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D010976:Platelet Count; D011379:Prognosis; D011446:Prospective Studies; D000072657:ST Elevation Myocardial Infarction / Q000175:diagnosis* / Q000601:surgery
keywords: ST-segment elevation myocardial infarction; mean platelet volume to platelet count ratio; primary percutaneous coronary angioplasty; prognosis