title: Chemically Locked Bicelles with High Thermal and Kinetic Stability.
abstract: In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to >90 °C) with excellent (2)H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models.
authors.affiliation: Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan).
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Matsui
authors.affiliation: RIKEN Center for Emergent Material Science, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan).
authors.forename: Masataka
authors.initials: M
authors.lastname: Ohtani
authors.affiliation: RIKEN Center for Emergent Material Science, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan).
authors.forename: Kuniyo
authors.initials: K
authors.lastname: Yamada
authors.affiliation: RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan).
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hikima
authors.affiliation: RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan).
authors.forename: Masaki
authors.initials: M
authors.lastname: Takata
authors.affiliation: RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan).
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan).
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koshino
authors.affiliation: RIKEN Center for Emergent Material Science, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan). y-ishida@riken.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ishida
authors.affiliation: RIKEN Center for Emergent Material Science, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan).|Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan).
authors.forename: Takuzo
authors.initials: T
authors.lastname: Aida
mesh_terms: D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D010743:Phospholipids / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D013696:Temperature
chemical_list: D010743:Phospholipids; D013501:Surface-Active Agents
keywords: biomembranes; phospholipids; polymerization; surfactants; templated synthesis