title: Methylene Blue-Mediated Photodynamic Inactivation Followed by Low-Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis.
abstract: OBJECTIVE
  Photodynamic therapy (PDT) appears to be an effective method for the in vitro and in vivo inactivation of Candida spp., but no clinical trials in this context have yet been conducted. The aim of this study was to compare the effect of oral miconazole gel to PDT combined with low-power laser (LPL) therapy in the treatment of denture stomatitis.
  
  
  METHODS
  Forty participants with clinical and microbiological diagnoses of type II denture stomatitis were randomly allocated to two treatment groups (PDT and miconazole gel), each with 20 individuals. The PDT group was submitted to one session of methylene blue-mediated PDT plus two sessions of low-laser therapy twice a week for 15 days. The miconazole group was submitted to the drug four times a day for 15 days.
  
  
  RESULTS
  Forty percent of the patients achieved clinical and microbiological resolution of denture stomatitis after methylene blue-mediated photodynamic inactivation followed by low-laser therapy. The cure rate associated with miconazole was 80% (p < 0.05). Fifteen days after the end of treatment, the recurrence rate was 25% in patients treated with PDT combined with LPL therapy and 12.5% in patients treated with miconazole.
  
  
  CONCLUSIONS
  Miconazole gel provides better results than a protocol combining methylene blue-mediated PDT and LPL therapy in the treatment of type II denture stomatitis.
authors.affiliation: Department of Dentistry, Federal University of Sergipe, São Cristóvão, Brazil.
authors.forename: Carolina Menezes
authors.initials: CM
authors.lastname: Maciel
authors.affiliation: Department of Dentistry, Federal University of Sergipe, São Cristóvão, Brazil.
authors.forename: Marta Rabello
authors.initials: MR
authors.lastname: Piva
authors.affiliation: Department of Dentistry, Federal University of Sergipe, São Cristóvão, Brazil.
authors.forename: Maria Amália Gonzaga
authors.initials: MA
authors.lastname: Ribeiro
authors.affiliation: Ribeirão Preto Dental School, University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: Thiago
authors.initials: T
authors.lastname: de Santana Santos
authors.affiliation: Department of Dentistry, Federal University of Sergipe, São Cristóvão, Brazil.
authors.forename: Cyntia Ferreira
authors.initials: CF
authors.lastname: Ribeiro
authors.affiliation: Department of Health Education, Federal University of Sergipe, Lagarto, Brazil.
authors.forename: Paulo Ricardo Saquete
authors.initials: PR
authors.lastname: Martins-Filho
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida; D006801:Humans; D053685:Laser Therapy; D008751:Methylene Blue / Q000627:therapeutic use; D008825:Miconazole / Q000627:therapeutic use*; D013282:Stomatitis, Denture / Q000628:therapy*
chemical_list: D000935:Antifungal Agents; D008825:Miconazole; D008751:Methylene Blue
keywords: Candida; denture stomatitis; low-laser therapy; miconazole; photodynamic therapy