title: Pleiotropic protective roles of melatonin against aluminium-induced toxicity in rats.
abstract: This study aimed to investigate the potential effects of melatonin on aluminium-induced toxicity in a rat model using a set of biochemical, inflammatory, oxidant, lipid profile criteria and hepatic integrity (verified by hematoxylin-eosin staining). The results indicated that AlCl3 administration during 60 days (100 mg/kg b.w.) significantly increased the activities of transaminases AST and ALT by 46% (p < 0.001) and 21% (p < 0.01), lactate dehydrogenase (LDH) by 30% (p < 0.001), the levels of bilirubin by 85% (p < 0.001), total cholesterol by 115% (p < 0.001), triglycerides by 130% (p < 0.001), LDL-cholesterol by 413% (p < 0.001), oxidized LDL (oxLDL) by 51% (p < 0.01) and apolipoprotein B100 (apoB100) by 63% (p < 0.001), as compared to controls. The inflammatory markers (TNF-α, IL-2, and IL-6) were significantly increased (p < 0.001), associated to higher lipid peroxidation (TBARS) level. Also, both plasma HDL-cholesterol level and hepatic LDL receptors (p < 0.01) expression and antioxidant protein (SOD, CAT, and GPx) activities are decreased. Those physiological disturbances were, however, noted to alleviate following the co-administration of melatonin (10 mg/kg b.w.). Overall, the present study is the first to provide evidence on the anti-inflammatory, anti-oxidant, anti-lipidic and, hence, therapeutic effects of melatonin with regard to the control and prevention of aluminium-intoxication.
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Allagui
authors.forename: Rafik
authors.initials: R
authors.lastname: Hachani
authors.forename: Saber
authors.initials: S
authors.lastname: Saidi
authors.forename: Anouer
authors.initials: A
authors.lastname: Feriani
authors.forename: Jean C
authors.initials: JC
authors.lastname: Murat
authors.forename: Kamel
authors.initials: K
authors.lastname: Kacem
authors.forename: Abdelfatteh
authors.initials: A
authors.lastname: El feki
mesh_terms: D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008055:Lipids / Q000097:blood*; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D008055:Lipids; D017382:Reactive Oxygen Species; D000535:Aluminum; D008550:Melatonin