title: Human neutrophils dump Candida glabrata after intracellular killing.
abstract: Interaction between fungal pathogens and human phagocytes can lead to remarkably variable outcomes, ranging from intracellular killing to prolonged survival and replication of the pathogen in the host cell. Using live cell imaging we observed primary human neutrophils that release phagocytosed Candida glabrata yeast cells after intracellular killing. This process, for which we propose the name "dumping", adds a new outcome to phagocyte-fungus interaction which may be of potential immunological importance as it allows professional antigen presenting cells to take up and process neutrophil-inactivated pathogens that in their viable state are able to evade intracellular degradation in these cells.
authors.affiliation: Septomics Research Center, Friedrich Schiller University Jena, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, Jena, Germany; Center for Sepsis Control and Care, University Hospital Jena, Jena, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Essig
authors.affiliation: Septomics Research Center, Friedrich Schiller University Jena, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, Jena, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Hünniger
authors.affiliation: Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, Jena, Germany; Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Jena, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Dietrich
authors.affiliation: Center for Sepsis Control and Care, University Hospital Jena, Jena, Germany; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, Jena, Germany; Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Jena, Germany.
authors.forename: Marc Thilo
authors.initials: MT
authors.lastname: Figge
authors.affiliation: Septomics Research Center, Friedrich Schiller University Jena, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, Jena, Germany; Center for Sepsis Control and Care, University Hospital Jena, Jena, Germany; German National Reference Center for Invasive Fungal Infections, Hans-Knoell-Institute, Jena, Germany. Electronic address: oliver.kurzai@hki-jena.de.
authors.forename: Oliver
authors.initials: O
authors.lastname: Kurzai
mesh_terms: D056704:Adaptive Immunity; D041221:Candida glabrata / Q000166:cytology / Q000276:immunology*; D002478:Cells, Cultured; D003593:Cytoplasm / Q000276:immunology / Q000382:microbiology; D006801:Humans; D009504:Neutrophils / Q000166:cytology / Q000276:immunology* / Q000382:microbiology*; D010587:Phagocytosis / Q000276:immunology*
keywords: Candida glabrata; Neutrophils; Phagocytosis