title: Epidemiologic Features of Kawasaki Disease in Shanghai From 2008 Through 2012.
abstract: BACKGROUND
  This study was to investigate the epidemiologic trends of Kawasaki disease (KD) and coronary arterial lesions (CALs) in Shanghai from 2008 through 2012.
  
  
  METHODS
  Data were collected by using the network of the KD research group established during the first survey in Shanghai to conduct the third survey, covering the period from 2008 through 2012. Clinical records of 2304 patients with acute KD were retrospectively reviewed. Epidemiologic features of KD were investigated. Univariate and multivariate analyses were performed to identify the risk factors for CAL in patients with KD. The data were compared with the previous 2 surveys covering the periods from 1998 to 2002 and 2003 to 2007, respectively.
  
  
  RESULTS
  The average incidence of KD was 30.3 to 71.9 per 100,000 children aged 0-4 years from 2008 through 2012. Age at onset ranged from 32 days to 11.7 years (median: 2.3 years). The occurrence of KD was more common in summer and spring. A total of 365 (15.9%) cases developed CAL defined as ectasia or aneurysm. Male, age ≤ 1 year, intravenous immunoglobulin (IVIG) unresponsiveness, a smaller administrative dosage and the delayed administration of IVIG (>10 days) were independent risk factors for CAL. The occurrence of CAL seemed less frequent in patients who received IVIG within 5 days after onset of illness.
  
  
  CONCLUSIONS
  The incidence of KD in children has increased over time, and the development of CAL decreased in the past 5 years in Shanghai. Earlier treatment with IVIG (<5 days) was associated with reduced CAL among patients with KD.
authors.affiliation: From the *Pediatric Heart Center, Children's Hospital of Fudan University; †Pediatric Heart Center, Shanghai Children's Medical Center; and ‡The Speciality of Cardiovascular Disease, Children's Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Chen
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Ma
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Yan
authors.forename: Mei-Rong
authors.initials: MR
authors.lastname: Huang
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Huang
mesh_terms: D017677:Age Distribution; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003331:Coronary Vessels / Q000473:pathology; D004452:Echocardiography; D005260:Female; D049674:History, 21st Century; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000266:history; D062486:Public Health Surveillance; D012008:Recurrence; D012307:Risk Factors; D012621:Seasons; D012737:Sex Factors
chemical_list: D016756:Immunoglobulins, Intravenous