title: [Association between the presence of antiphospholipid antibodies and the occurrence of autism spectrum disorder in childhood].
abstract: OBJECTIVE
  To evaluate the association between the presence of antiphospholipid (APL) antibodies and the occurrence of autism spectrum disorder (ASD) in childhood.
  
  
  METHODS
  A prospective, monocentric case-control study from February 2012 to August 2014 comparing the APL antibodies of children with ASD (group 1) and children without ASD (group 2).
  
  
  RESULTS
  Group 1 consisted of 44 children with ASD defined by clinical, genetic, metabolic, and morphological criteria. Group 2 consisted of 26 control children without ASD. One of children with ASD (2.3 %) had persistent anticardiolipin (ACL) antibodies, five of them (11.4 %) had persistent APL antibodies, one of them (2.3 %) had antiannexin V (AAV) antibodies, and two of them (4.5 %) had antiphosphatidylethanolamine (APE) antibodies. Two of the control children (7.7 %) had persistent APL antibodies. None of them had persistent ACL, AAV, or APE antibodies. Comparing group 1 and 2 children, no significant difference was found between the presence and the titers of conventional and non conventional antibodies (P<0.05). Furthermore, one mother of an autistic child (3 %) had persistent APL antibodies.
  
  
  CONCLUSIONS
  ASD had no significant relation with the presence of APL antibodies.
authors.affiliation: Service de pédiatrie, hôpital Jean-Verdier, AP-HP, université Paris 13, avenue du 14-Juillet, 93143 Bondy, France.
authors.forename: F
authors.initials: F
authors.lastname: Lageix
authors.affiliation: Laboratoire d'immunologie, UF d'auto-immunité et hypersensibilité, hôpital Bichat, AP-HP, 75018 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Nicaise-Roland
authors.affiliation: Service de pédiatrie, hôpital Jean-Verdier, AP-HP, université Paris 13, avenue du 14-Juillet, 93143 Bondy, France.
authors.forename: M
authors.initials: M
authors.lastname: Houlier
authors.affiliation: Unité de dépistage et d'évaluation pluriprofessionnelle de l'autisme et des troubles apparentés (UNIDEP), EPS de Ville-Evrard (pôle I05), 93332 Neuilly-sur-Marne, France.
authors.forename: P
authors.initials: P
authors.lastname: Zylberberg
authors.affiliation: Service de pédiatrie, hôpital Jean-Verdier, AP-HP, université Paris 13, avenue du 14-Juillet, 93143 Bondy, France.
authors.forename: M
authors.initials: M
authors.lastname: Dubrel
authors.affiliation: Unité de dépistage et d'évaluation pluriprofessionnelle de l'autisme et des troubles apparentés (UNIDEP), EPS de Ville-Evrard (pôle I05), 93332 Neuilly-sur-Marne, France.
authors.forename: M
authors.initials: M
authors.lastname: Heulin
authors.affiliation: Service de médecine interne, hôpital Saint-Antoine, AP-HP, DHU i2B, université Paris 6, 75012 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Fain
authors.affiliation: Service de pédiatrie, hôpital Jean-Verdier, AP-HP, université Paris 13, avenue du 14-Juillet, 93143 Bondy, France.
authors.forename: E
authors.initials: E
authors.lastname: Lachassinne
authors.affiliation: Service de pédiatrie, hôpital Jean-Verdier, AP-HP, université Paris 13, avenue du 14-Juillet, 93143 Bondy, France.
authors.forename: B
authors.initials: B
authors.lastname: Héron
authors.affiliation: Laboratoire d'immunologie, UF d'auto-immunité et hypersensibilité, hôpital Bichat, AP-HP, 75018 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Chollet-Martin
authors.affiliation: Service de médecine interne, hôpital Saint-Antoine, AP-HP, DHU i2B, université Paris 6, 75012 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Mekinian
authors.affiliation: Service de pédiatrie, hôpital Jean-Verdier, AP-HP, université Paris 13, avenue du 14-Juillet, 93143 Bondy, France. Electronic address: loic.de-pontual@jvr.aphp.fr.
authors.forename: L
authors.initials: L
authors.lastname: de Pontual
mesh_terms: D017304:Annexin A5 / Q000276:immunology; D000906:Antibodies / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D000067877:Autism Spectrum Disorder / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010714:Phosphatidylethanolamines / Q000276:immunology; D011446:Prospective Studies
chemical_list: D017304:Annexin A5; D000906:Antibodies; D017152:Antibodies, Antiphospholipid; D010714:Phosphatidylethanolamines; C483858:phosphatidylethanolamine