title: Postoperative fungal endophthalmitis caused by Trichosporon asahii treated with voriconazole.
abstract: Postoperative fungal endophthalmitis is a rare but devastating complication of cataract surgery. Vitrectomy and intravitreal amphotericin B injection as well as administration of systemic antifungal agents have been suggested as optimal treatments for fungal endophthalmitis. However, this therapy may fail to eliminate fungal species resistant to current antifungal agents. The saprophytic fungus Trichosporon asahii is frequently observed as a cause of endogenous endophthalmitis in immunosuppressed patients. We report a case of postoperative endophthalmitis caused by T. asahii, resistant to amphotericin B. To the best of our knowledge, this is the first report of T. asahii endophthalmitis successfully treated with intravitreal and systemic voriconazole, pars plana vitrectomy, and removal of the intraocular lens and entire lens capsule.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Selcuk University, Konya, TR.
authors.forename: Saban
authors.initials: S
authors.lastname: Gonul
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Selcuk University, Konya, TR.
authors.forename: Sansal
authors.initials: S
authors.lastname: Gedik
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Selcuk University, Konya, TR.
authors.forename: Banu Turgut
authors.initials: BT
authors.lastname: Ozturk
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Selcuk University, Konya, TR.
authors.forename: Berker
authors.initials: B
authors.lastname: Bakbak
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Selcuk University, Konya, TR.
authors.forename: Bengu Ekinci
authors.initials: BE
authors.lastname: Koktekir
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Selcuk University, Konya, TR.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Okudan
authors.affiliation: Department of Microbiology, Faculty of Medicine, Selcuk University, Konya, TR.
authors.forename: Hatice Turk
authors.initials: HT
authors.lastname: Dagı
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D002387:Cataract Extraction / Q000009:adverse effects*; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D014250:Trichosporon / Q000145:classification / Q000302:isolation & purification; D060586:Trichosporonosis / Q000188:drug therapy*; D065819:Voriconazole / Q000008:administration & dosage*
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole