title: Plasma Metanephrines Are Associated With Glucose Metabolism in Patients With Essential Hypertension.
abstract: There is a high incidence of glucose intolerance in essential hypertension. Overactivation of the sympathetic system is one of important causes of essential hypertension. Whether sympathetic system affects glucose metabolism in patients with essential hypertension has never been reported previously. The aim of this study was to explore the association between the sympathetic system activity and glucose metabolism in patients with essential hypertension. A total of 202 essential hypertension inpatients without diabetes were recruited from Shanghai Ruijin Hospital between February 2006 and August 2013. Activity of sympathetic system was quantified by plasma metanephrines (MNs) levels. All subjects received an oral glucose tolerance test. Fasting plasma glucose and 2-hour plasma glucose increased significantly across the quartiles of plasma MNs. The multiple linear regression analysis revealed that plasma MNs were significantly associated with fasting plasma glucose and 2-hour plasma glucose. The area under curve of plasma glucose increased significantly from the lowest plasma MNs quartile across to the highest quartile. The multiple logistic regression analysis revealed that odds ratios (95% confidence interval) for prediabetes in the highest quartile compared with the lowest quartile of plasma MNs was 4.00 (95% confidence interval, 1.16-13.86). Plasma MNs levels are positively associated with plasma glucose in patients with essential hypertension. Patients with high plasma MNs levels had an increased risk of prediabetes.
authors.affiliation: From the Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases (WW, LM, TS, LY, YJ, LJ, WZ); Chinese Research Center for Metabolic Diseases, School of Medicine, Ruijin Hospital, Shanghai JiaoTong University, Shanghai, PR China (WW, LM, TS, LY, YJ, LJ, WZ).
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.forename: Liangshan
authors.initials: L
authors.lastname: Mu
authors.forename: Tingwei
authors.initials: T
authors.lastname: Su
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.forename: Yiran
authors.initials: Y
authors.lastname: Jiang
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhou
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008676:Metanephrine / Q000097:blood*; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood
chemical_list: D001786:Blood Glucose; D008676:Metanephrine