title: OPN gene polymorphisms, rs17524488 GG/G, rs11730582 T/C, and rs9138 C/A, and cancer risk in a Chinese population.
abstract: Previous studies have investigated the association between osteopontin (OPN) gene polymorphisms, rs17524488 (-156 GG/G), rs11730582 (-443 T/C), and rs9138 (C/A) and cancer risk in the Chinese population. However, the results are controversial and indefinite. We therefore carried out a meta-analysis to derive a more precise estimation of these associations. The PubMed database was systematically searched to identify potentially eligible reports. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations between 3 OPN gene polymorphisms and cancer risk in a Chinese population. A total of 10 articles involving 2,391 cases and 3,007 controls were evaluated. The pooled OR indicated that OPN rs17524488 (-156 GG/G) polymorphism was significantly associated with cancer risk in Chinese population. In a stratified analysis by source of control, significant associations were also observed among rs17524488 (-156 GG/G) and rs11730582 (-443 T/C) polymorphisms and cancer. In addition, a stronger association was observed between rs9138 (C/A) polymorphism and cancer risk. In conclusion, this meta-analysis suggests that OPN rs17524488 (-156 GG/G), rs11730582 (-443 T/C), and rs9138 (C/A) polymorphisms may be associated with cancer susceptibility in the Chinese population. Nevertheless, further investigation on a larger population covering different ethnicities are warranted.
authors.affiliation: Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, 214000, P. R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Mi
authors.affiliation: Department of Orthopedics, The Affiliated Jiangyin Hospital of Southeast University Medical School, Wuxi, 214000, P. R. China.
authors.forename: Kewei
authors.initials: K
authors.lastname: Ren
authors.affiliation: Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, 214000, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Dai
authors.affiliation: Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, 214000, P. R. China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Translational Medicine Center, The Affiliated Wuxi Second People's Hospital of of Nanjing Medical University, Wuxi 214000, P. R. China.
authors.forename: Ninghan
authors.initials: N
authors.lastname: Feng
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D053495:Osteopontin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D017594:Publication Bias; D012306:Risk
chemical_list: D053495:Osteopontin