title: Diastereoselective synthesis of spiro[benzo[d]pyrrolo[2,1-b]thiazole-3,3'-indolines] via cycloaddition reaction of N-phenacylbenzothiazolium bromides and 3-methyleneoxindoles.
abstract: The domino cycloaddition reactions of N-phenacylbenzothiazolium bromides with 3-phenacylideneoxindoles or ethyl 2-(2-oxoindolin-3-ylidene)acetates in ethanol at room temperature in the presence of triethylamine as a base afforded functionalized spiro[benzo[d]pyrrolo[2,1-b]thiazole-3,3'-indolines] in good yields and with high diastereoselectivity. The similar reactions of N-phenacylthiazolium bromides with 3-phenacylideneoxindoles resulted in the corresponding functionalized spiro[indoline-3,7'-pyrrolo[2,1-b]thiazoles] in satisfactory yields and also with high diastereoselectivity.
authors.affiliation: College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China. cgyan@yzu.edu.cn.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Shen
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Chao-Guo
authors.initials: CG
authors.lastname: Yan