title: Genetic analysis of the RELN gene: Gender specific association with Alzheimer's disease.
abstract: Association between genetic variants of the reelin (RELN) gene and the risk for developing Alzheimer's disease (AD) was examined in a sample of 432 patients and 308 controls. Single marker and haplotype analyses revealed that the strongly linked rs528528 and rs607755 polymorphisms are associated with AD risk in a gender specific manner. Among men, but not in women the rs528528 T/T and rs607755 A/A genotypes were significantly associated with the susceptibility to AD.
authors.affiliation: Department of Psychiatry, University of Szeged, Szeged, Hungary. Electronic address: feher.agnes@med.u-szeged.hu.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Fehér
authors.affiliation: Department of Psychiatry, University of Szeged, Szeged, Hungary.
authors.forename: Anna
authors.initials: A
authors.lastname: Juhász
authors.affiliation: Department of Psychiatry, University of Szeged, Szeged, Hungary.
authors.forename: Magdolna
authors.initials: M
authors.lastname: Pákáski
authors.affiliation: Department of Psychiatry, University of Szeged, Szeged, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Kálmán
authors.affiliation: Department of Psychiatry, University of Szeged, Szeged, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Janka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000235:genetics*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000235:genetics*; D012727:Sex Characteristics
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D005819:Genetic Markers; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human; D012697:Serine Endopeptidases
keywords: Alzheimer's disease; Association study; Reelin (RELN)