title: A new phenylethanoid glycoside from Orobanche cernua Loefling.
abstract: A novel phenylethanoid glycoside, 3'-O-methyl isocrenatoside (1), along with two known compounds, methyl caffeate (2) and protocatechuic aldehyde (3), were isolated from the fresh whole plant of Orobanche cernua Loefling. All the isolated compounds (1-3) were elucidated on the basis of spectroscopic analysis including IR, MS and NMR data. The cytotoxic activities of these compounds were evaluated. Results showed that 3'-O-methyl isocrenatoside (1) and methyl caffeate (2) exhibited significant cytotoxicity, with IC50 values of 71.89, 36.97 μg/mL and 32.32, 34.58 μg/mL against the B16F10 murine melanoma and Lewis lung carcinoma cell lines, respectively.
authors.affiliation: a Chinese Academy of Agricultural Sciences , Institute of Special Wild Economic Animals and Plants , Changchun , PR China.
authors.forename: Zheng-yi
authors.initials: ZY
authors.lastname: Qu
authors.affiliation: a Chinese Academy of Agricultural Sciences , Institute of Special Wild Economic Animals and Plants , Changchun , PR China.
authors.forename: Yu-wei
authors.initials: YW
authors.lastname: Zhang
authors.affiliation: a Chinese Academy of Agricultural Sciences , Institute of Special Wild Economic Animals and Plants , Changchun , PR China.
authors.forename: Si-Wen
authors.initials: SW
authors.lastname: Zheng
authors.affiliation: a Chinese Academy of Agricultural Sciences , Institute of Special Wild Economic Animals and Plants , Changchun , PR China.
authors.forename: Chun-lin
authors.initials: CL
authors.lastname: Yao
authors.affiliation: a Chinese Academy of Agricultural Sciences , Institute of Special Wild Economic Animals and Plants , Changchun , PR China.
authors.forename: Yin-ping
authors.initials: YP
authors.lastname: Jin
authors.affiliation: a Chinese Academy of Agricultural Sciences , Institute of Special Wild Economic Animals and Plants , Changchun , PR China.
authors.forename: Pei-he
authors.initials: PH
authors.lastname: Zheng
authors.affiliation: a Chinese Academy of Agricultural Sciences , Institute of Special Wild Economic Animals and Plants , Changchun , PR China.
authors.forename: Cheng-he
authors.initials: CH
authors.lastname: Sun
authors.affiliation: a Chinese Academy of Agricultural Sciences , Institute of Special Wild Economic Animals and Plants , Changchun , PR China.
authors.forename: Ying-ping
authors.initials: YP
authors.lastname: Wang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D001547:Benzaldehydes / Q000737:chemistry / Q000302:isolation & purification; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification; D002396:Catechols / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D031672:Orobanche / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry
chemical_list: C000612021:3'-O-methyl isocrenatoside; D000972:Antineoplastic Agents, Phytogenic; D001547:Benzaldehydes; D002109:Caffeic Acids; D002396:Catechols; D006027:Glycosides; D010936:Plant Extracts; C042405:methyl caffeate; C005581:protocatechualdehyde
keywords: Orobanchaceae; Orobanche cernua Loefling; cytotoxicity; phenylethanoid glycoside