title: Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging α-Amino Acids.
abstract: Structurally simple and inexpensive chiral tridentate ligands were employed for substantially advancing the purely chemical dynamic kinetic resolution (DKR) of unprotected racemic tailor-made α-amino acids (TM-α-AAs), enabling the first DKR of TM-α-AAs bearing tertiary alkyl chains as well as multiple unprotected functional groups. Owing to the operationally convenient conditions, virtually complete stereoselectivity, and full recyclability of the source of chirality, this method should find wide applications for the preparation of TM-α-AAs, especially on large scale.
authors.affiliation: School of Pharmacy, China Pharmaceutical University, Jiangsu, Nanjing 210009 (China).|Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (China).
authors.forename: Yong
authors.initials: Y
authors.lastname: Nian
authors.affiliation: Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (China).
authors.forename: Jiang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (China).
authors.forename: Shengbin
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (China).
authors.forename: Shuni
authors.initials: S
authors.lastname: Wang
authors.affiliation: Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024 (Japan).
authors.forename: Hiroki
authors.initials: H
authors.lastname: Moriwaki
authors.affiliation: Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024 (Japan).
authors.forename: Aki
authors.initials: A
authors.lastname: Kawashima
authors.affiliation: Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián (Spain). vadym.soloshonok@ehu.es.|IKERBASQUE, Basque Foundation for Science, Alameda Urquijo 36-5, Plaza Bizkaia, 48013 Bilbao (Spain). vadym.soloshonok@ehu.es.
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Soloshonok
authors.affiliation: School of Pharmacy, China Pharmaceutical University, Jiangsu, Nanjing 210009 (China). hliu@simm.ac.cn.|Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (China). hliu@simm.ac.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D000596:Amino Acids; D008024:Ligands; D009942:Organometallic Compounds; D009532:Nickel
keywords: N ligands; amino acids; enantioselectivity; kinetic resolution; nickel