title: Maternal Psychiatric Disorder and the Risk of Autism Spectrum Disorder or Intellectual Disability in Subsequent Offspring.
abstract: Psychiatric disorders are more common in the mothers of children with autism spectrum disorder (ASD) or intellectual disability (ID) after the birth of their child. We aimed to assess the relationship between women's psychiatric contacts and subsequent offspring with ASD/ID. We linked three Western Australian registers to investigate pre-existing maternal outpatient psychiatric contacts and the odds of ASD/ID in a subsequent child. Women with a previous outpatient psychiatric contact were more than twice as likely to have a child with ASD [OR 2.07 (95 % CI 1.7, 2.6)] or ID [OR 2.31 (2.1, 2.6)]. Further research exploring the effect on pregnancy outcomes of medications prescribed to women with psychiatric disorders is implicated.
authors.affiliation: Telethon Kids Institute, University of Western Australia, Perth, Australia. Jenny.Fairthorne@telethonkids.org.au.
authors.forename: Jenny
authors.identifier: http://orcid.org/0000-0002-6667-8426
authors.initials: J
authors.lastname: Fairthorne
authors.affiliation: Health Department of Western Australia, Perth, Australia.
authors.forename: Geoff
authors.initials: G
authors.lastname: Hammond
authors.affiliation: Telethon Kids Institute, University of Western Australia, Perth, Australia.
authors.forename: Jenny
authors.initials: J
authors.lastname: Bourke
authors.affiliation: Telethon Kids Institute, University of Western Australia, Perth, Australia.
authors.forename: Nick
authors.initials: N
authors.lastname: de Klerk
authors.affiliation: Telethon Kids Institute, University of Western Australia, Perth, Australia.
authors.forename: Helen
authors.initials: H
authors.lastname: Leonard
mesh_terms: D000328:Adult; D001315:Australia; D000067877:Autism Spectrum Disorder / Q000235:genetics*; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D008607:Intellectual Disability / Q000235:genetics*; D001523:Mental Disorders / Q000235:genetics*; D009035:Mothers / Q000523:psychology*; D055815:Young Adult
keywords: Autism; Intellectual; Mothers; Pre-existing; Prenatal medication; Psychiatric