title: Lacosamide Induced Psychosis: Case Report, Review of Differential Diagnosis and Relevant Pharmacokinetics.
abstract: Lacosamide (LCM) is an antiepileptic medication used as an adjunctive treatment for partial seizures. Psychosis associated with LCM use is a rarely documented phenomenon, which may be difficult to detect in the context of the often complicated clinical presentation of epilepsy. We report the development of psychosis in a young woman after the use of LCM, which subsequently resolved with its discontinuation. The possible differential diagnosis and pharmacokinetic nuances are discussed. This is the first case report of LCM-induced psychosis in the United States.
authors.affiliation: *Department of Behavioral Health, Winthrop University Hospital, Mineola; †Stony Brook School of Medicine, Stony Brook; ‡Department of Pharmacy Services, Kingsbrook Jewish Medical Center and §Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, NY.
authors.forename: Aaron
authors.initials: A
authors.lastname: Pinkhasov
authors.forename: Timothy
authors.initials: T
authors.lastname: Lam
authors.forename: Dillon
authors.initials: D
authors.lastname: Hayes
authors.forename: Michelle
authors.initials: M
authors.lastname: Friedman
authors.forename: Deepan
authors.initials: D
authors.lastname: Singh
authors.forename: Henry
authors.initials: H
authors.lastname: Cohen
mesh_terms: D000081:Acetamides / Q000009:adverse effects* / Q000493:pharmacokinetics*; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics; D003937:Diagnosis, Differential; D004347:Drug Interactions / Q000235:genetics; D005260:Female; D006801:Humans; D000078334:Lacosamide; D011605:Psychoses, Substance-Induced / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide