title: Simvastatin Use in Patients with Type 2 Diabetes Mellitus: The Effects on Oxidative Stress.
abstract: OBJECTIVE
  Studies have shown that people with type 2 diabetes mellitus (T2DM) may develop atherosclerosis due to the disturbance in oxidative control and progressive dyslipidemia. Our study aimed to highlight the benefits of simvastatin treatment in improving serum lipids and reducing oxidative damage in patients with T2DM.
  
  
  METHODS
  Our randomized control trial included 56 patients with T2DM and dyslipidemia. The participants were on glibenclamide (5mg/day) during the period of the study. The patients were divided into two study groups (groups 1 and 2). Group 1 was the control group and consisted of 31 patients. Group 2 consisted of 25 participants, who were given simvastatin 20mg tablet once daily for 12 weeks. The control group did not receive simvastatin. Both groups were followed-up for measurement of blood pressure, pulse rate, serum lipids, and parameters of oxidative stress.
  
  
  RESULTS
  The simvastatin treated group showed a significant improvement with reduced erythrocyte glutathione compared to the control group (p<0.001). This was also associated with a significant reduction in erythrocyte malondialdehyde in the simvastatin treated group compared to the control group (p<0.001). Serum lipids reflected a similar improvement in the levels of erythrocyte malondialdehyde.
  
  
  CONCLUSIONS
  Our study highlights the beneficial role of simvastatin in improving the degree of oxidative stress in patients with T2DM through its effects on serum lipids and lipid peroxidation.
authors.affiliation: Department of Pharmacology, Kufa University, Najaf, Iraq.
authors.forename: Najah R
authors.initials: NR
authors.lastname: Hadi
authors.affiliation: Department of Medicine, Kufa University, Najaf, Iraq.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Abdelhussein
authors.affiliation: Department of Pharmacology, Kufa University, Najaf, Iraq.
authors.forename: Ammar R M
authors.initials: AR
authors.lastname: Rudha
authors.affiliation: School of Medicine, University of Tasmania, Tasmania, Australia.
authors.forename: Dina A
authors.initials: DA
authors.lastname: Jamil
authors.affiliation: School of Medicine, University of Tasmania, Tasmania, Australia.
authors.forename: Hayder A
authors.initials: HA
authors.lastname: Al-Aubaidy
keywords: Antioxidants; Diabetes Mellitus, Type 2; Dyslipidemias; Simvastatin