title: [Mechanism of Platinum Derivatives Induced Kidney Injury].
abstract: Platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors, lung cancer, and colorectal cancer. Two major problems exist, however, in the clinic use of platinum derivatives. One is the development of tumor resistance to the drug during therapy, leading to treatment failure. The other is the drug's toxicity such as the cisplatin's nephrotoxicity, which limits the dose that can be administered. This paper describes the mechanism of platinum derivatives induced kidney injury.
authors.affiliation: Department of Thoracic Medical Oncology, Beijing Cancer Hospital and Institute, Peking University, Beijing 100142, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Yan
authors.affiliation: Department of Thoracic Medical Oncology, Beijing Cancer Hospital and Institute, Peking University, Beijing 100142, China.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Duan
authors.affiliation: Department of Thoracic Medical Oncology, Beijing Cancer Hospital and Institute, Peking University, Beijing 100142, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000737:chemistry*; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism; D010984:Platinum / Q000009:adverse effects* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010984:Platinum