title: New cancer therapies and jaw necrosis.
abstract: Osteonecrosis of the jaw (ONJ) has a number of causes, the most familiar being radiation or bisphosphonate induced. Various other novel anti-neoplastic and bone-targeting therapies that can also cause jaw necrosis have recently become available. This has led to the suggested acronym MRONJ for medication-related osteonecrosis of the jaw. This article summarises the available information on these drugs and their implications for the dental surgeon.
authors.affiliation: Oral Surgery Dept, Floor 23, Guys Dental Hospital, London Bridge, London, SE1 9RT.
authors.forename: V
authors.initials: V
authors.lastname: Patel
authors.affiliation: Restorative Dept. King's College Hospital, London, SE5 9RW.
authors.forename: M
authors.initials: M
authors.lastname: Kelleher
authors.affiliation: Oral Surgery Dept, Floor 23, Guys Dental Hospital, London Bridge, London, SE1 9RT.
authors.forename: C
authors.initials: C
authors.lastname: Sproat
authors.affiliation: Oral Surgery Dept, Floor 23, Guys Dental Hospital, London Bridge, London, SE1 9RT.
authors.forename: J
authors.initials: J
authors.lastname: Kwok
authors.affiliation: Department of Oral and Maxillofacial Surgery, Atrium 3, 3rd Floor, Bermondsey Wing, Guy's Hospital, London, SE1 9RT.
authors.forename: M
authors.initials: M
authors.lastname: McGurk
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000517:prevention & control; D006801:Humans; D007571:Jaw Diseases / Q000209:etiology* / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D010020:Osteonecrosis / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents