title: Reliability and Validity of Selected PROMIS Measures in People with Rheumatoid Arthritis.
abstract: OBJECTIVE
  To evaluate the reliability and validity of 11 PROMIS measures to assess symptoms and impacts identified as important by people with rheumatoid arthritis (RA).
  
  
  METHODS
  Consecutive patients (N = 177) in an observational study completed PROMIS computer adapted tests (CATs) and a short form (SF) assessing pain, fatigue, physical function, mood, sleep, and participation. We assessed test-test reliability and internal consistency using correlation and Cronbach's alpha. We assessed convergent validity by examining Pearson correlations between PROMIS measures and existing measures of similar domains and known groups validity by comparing scores across disease activity levels using ANOVA.
  
  
  RESULTS
  Participants were mostly female (82%) and white (83%) with mean (SD) age of 56 (13) years; 24% had ≤ high school, 29% had RA ≤ 5 years with 13% ≤ 2 years, and 22% were disabled. PROMIS Physical Function, Pain Interference and Fatigue instruments correlated moderately to strongly (rho's ≥ 0.68) with corresponding PROs. Test-retest reliability ranged from .725-.883, and Cronbach's alpha from .906-.991. A dose-response relationship with disease activity was evident in Physical Function with similar trends in other scales except Anger.
  
  
  CONCLUSIONS
  These data provide preliminary evidence of reliability and construct validity of PROMIS CATs to assess RA symptoms and impacts, and feasibility of use in clinical care. PROMIS instruments captured the experiences of RA patients across the broad continuum of RA symptoms and function, especially at low disease activity levels. Future research is needed to evaluate performance in relevant subgroups, assess responsiveness and identify clinically meaningful changes.
authors.affiliation: Department of Medicine, Divisions of Clinical Epidemiology, Rheumatology, and Respiratory Epidemiology, McGill University / McGill University Health Centers, Montreal, QC, Canada; Department of Medicine, Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Bartlett
authors.affiliation: Department of Medicine, Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Orbai
authors.affiliation: Department of Medicine, Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
authors.forename: Trisha
authors.initials: T
authors.lastname: Duncan
authors.affiliation: Department of Medicine, Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
authors.forename: Elaine
authors.initials: E
authors.lastname: DeLeon
authors.affiliation: Department of Medicine, Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
authors.forename: Victoria
authors.initials: V
authors.lastname: Ruffing
authors.affiliation: Bloomberg School of Public Health, Center for Qualitative Studies in Health and Medicine, Johns Hopkins University, Baltimore, MD, United States of America.
authors.forename: Katherine
authors.initials: K
authors.lastname: Clegg-Smith
authors.affiliation: Department of Medicine, Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
authors.forename: Clifton O
authors.initials: CO
authors.lastname: Bingham
mesh_terms: D000786:Anger / Q000502:physiology; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000503:physiopathology*; D004185:Disability Evaluation; D005221:Fatigue / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D011446:Prospective Studies; D011594:Psychometrics / Q000379:methods; D011788:Quality of Life; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology; D011795:Surveys and Questionnaires