title: Structural self-organization of C60 and cisplatin in physiological solution.
abstract: The specific features of structural self-organization of C60 fullerene and antitumor drug cisplatin (Cis) in physiological solution (0.9% NaCl) have been investigated by means of small-angle neutron scattering, scanning electron and atomic force microscopies, as well as isothermal titration calorimetry, dynamic light scattering and UV-Vis spectroscopy. The formation of C60 + Cis complexes, has been reported, unveiling the mechanism of medico-biological synergy observed during administration of the mixture of these drugs.
authors.affiliation: Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64, 01601 Kyiv, Ukraine. prylut@ukr.net.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Prylutskyy
authors.forename: V V
authors.initials: VV
authors.lastname: Cherepanov
authors.forename: M P
authors.initials: MP
authors.lastname: Evstigneev
authors.forename: O A
authors.initials: OA
authors.lastname: Kyzyma
authors.forename: V I
authors.initials: VI
authors.lastname: Petrenko
authors.forename: V I
authors.initials: VI
authors.lastname: Styopkin
authors.forename: L A
authors.initials: LA
authors.lastname: Bulavin
authors.forename: N A
authors.initials: NA
authors.lastname: Davidenko
authors.forename: D
authors.initials: D
authors.lastname: Wyrzykowski
authors.forename: A
authors.initials: A
authors.lastname: Woziwodzka
authors.forename: J
authors.initials: J
authors.lastname: Piosik
authors.forename: R
authors.initials: R
authors.lastname: Kaźmierkiewicz
authors.forename: U
authors.initials: U
authors.lastname: Ritter
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D002151:Calorimetry; D002945:Cisplatin / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry*; D008027:Light; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D033363:Neutron Diffraction; D012542:Scattering, Radiation; D053838:Scattering, Small Angle; D012965:Sodium Chloride / Q000737:chemistry; D012996:Solutions
chemical_list: D000970:Antineoplastic Agents; D037741:Fullerenes; D012996:Solutions; D012965:Sodium Chloride; C069837:fullerene C60; D002945:Cisplatin