title: Metabolism and epigenetics.
abstract: Epigenetic mechanisms by which cells inherit information are, to a large extent, enabled by DNA methylation and posttranslational modifications of histone proteins. These modifications operate both to influence the structure of chromatin per se and to serve as recognition elements for proteins with motifs dedicated to binding particular modifications. Each of these modifications results from an enzyme that consumes one of several important metabolites during catalysis. Likewise, the removal of these marks often results in the consumption of a different metabolite. Therefore, these so-called epigenetic marks have the capacity to integrate the expression state of chromatin with the metabolic state of the cell. This review focuses on the central roles played by acetyl-CoA, S-adenosyl methionine, NAD(+), and a growing list of other acyl-CoA derivatives in epigenetic processes. We also review how metabolites that accumulate as a result of oncogenic mutations are thought to subvert the epigenetic program.
authors.affiliation: Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, California 94720.
authors.forename: Ryan
authors.initials: R
authors.lastname: Janke
authors.affiliation: Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, California 94720.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Dodson
authors.affiliation: Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, California 94720.
authors.forename: Jasper
authors.initials: J
authors.lastname: Rine
mesh_terms: D000105:Acetyl Coenzyme A / Q000235:genetics; D000818:Animals; D002843:Chromatin / Q000502:physiology; D019175:DNA Methylation / Q000235:genetics / Q000502:physiology; D044127:Epigenesis, Genetic / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D009243:NAD / Q000235:genetics; D011499:Protein Processing, Post-Translational / Q000235:genetics / Q000502:physiology; D012436:S-Adenosylmethionine / Q000235:genetics
chemical_list: D002843:Chromatin; D009243:NAD; D000105:Acetyl Coenzyme A; D012436:S-Adenosylmethionine
keywords: S-adenosyl methionine; acetylation; chromatin modification; folate; methylation; oncometabolite