title: An efficient S-NO-polysilsesquioxane nano-platform for the co-delivery of nitric oxide and an anticancer drug.
abstract: Codelivery of nitric oxide (NO) and drugs based on a single nanocarrier is a promising therapeutic strategy. Here, we report a one-step nanoprecipitation method to generate nanoparticles that possess simultaneous NO-donating and doxorubicin releasing properties. S-Nitroso polysilsesquioxane acts like an avid "drug sponge" that attracts drug molecules into nanospheres.
authors.affiliation: School of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan, Republic of China. tmhu@ndmctsgh.edu.tw.
authors.forename: Meng-Ren
authors.initials: MR
authors.lastname: Wang
authors.forename: Shih-Jiuan
authors.initials: SJ
authors.lastname: Chiu
authors.forename: Hung-Chang
authors.initials: HC
authors.lastname: Chou
authors.forename: Teh-Min
authors.initials: TM
authors.lastname: Hu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D065546:Drug Liberation; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry; D009569:Nitric Oxide / Q000008:administration & dosage / Q000737:chemistry; D017646:Organosilicon Compounds / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D017646:Organosilicon Compounds; C569780:polysilsesquioxane; D009569:Nitric Oxide; D004317:Doxorubicin