title: Systematic and Meta-Analytic Review: Medication Adherence Among Pediatric Patients With Sickle Cell Disease.
abstract: OBJECTIVE
  To provide a comprehensive summary (systematic review) of medication adherence rates by assessment method and medication type for pediatric patients with sickle cell disease (SCD), as well as identify important correlates for future research.
  
  
  METHODS
  Articles assessing medication adherence and published between 1982 and February 2015 (n = 49) were identified using electronic databases. A meta-analysis of 14 studies examining demographic, medical, and psychosocial factors and medication adherence was conducted.
  
  
  RESULTS
  Adherence rates ranged from 12% to 100% across all medications. Approximately 30% of studies reported associations between adherence and key demographic, medical, and psychosocial correlates. Mean effect sizes were small to moderate (r = .02-.53).
  
  
  CONCLUSIONS
  The wide range of adherence rates reported in the literature may be because of, in part, the use of variable assessment strategies. Future studies examining pediatric SCD adherence should incorporate key correlates with the goal of replication.
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center kristin.loiselle@cchmc.org.
authors.forename: Kristin
authors.initials: K
authors.lastname: Loiselle
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Lee
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
authors.forename: Lauren
authors.initials: L
authors.lastname: Szulczewski
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
authors.forename: Sarah
authors.initials: S
authors.lastname: Drake
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
authors.forename: Lori E
authors.initials: LE
authors.lastname: Crosby
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
authors.forename: Ahna L H
authors.initials: AL
authors.lastname: Pai
mesh_terms: D000755:Anemia, Sickle Cell / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D006801:Humans; D055118:Medication Adherence / Q000523:psychology; D016903:Drug Monitoring
keywords: adherence; children; meta-analysis; sickle cell disease; systematic review