title: Rotational thromboelastometry in the diagnosis of coagulopathy in major pediatric surgical operations.
abstract: OBJECTIVE
  To examine the correlation between rotational thromboelastometry (ROTEM) and coagulopathy after major pediatric surgical operations.
  
  
  METHODS
  From November 2013 until April 2015, pediatric cases who underwent major noncardiac surgeries and met the coagulopathy-risk criteria were reviewed for postoperative clinically significant coagulopathy (CSC). Two ROTEM studies, EXTEM and INTEM, were performed at the immediately postoperatively without the results being taken into any clinical decision making.
  
  
  RESULTS
  Seventy-seven operations on 73 patients were included in this analysis. CSC occurred following 24 operations (32%) with a significantly higher incidence when a patient had a higher coagulopathy risk. On univariate analysis, evidence of diffuse bleeding in the operative field and massive bleeding were the 2 parameters with the strongest association with CSC. INTEM and EXTEM had specificities in diagnosing CSC of 75.5% and 94.3%, respectively. When each individual EXTEM and INTEM item was analyzed against CSC using ROC analysis, clot forming time (CFT) gave the largest under the curve area. The cut-off CFTs that gave the highest sensitivity and specificity in this study were 120seconds for EXTEM and 100seconds for INTEM.
  
  
  CONCLUSIONS
  Postoperative coagulopathy is a risk that should always be considered in pediatric surgical operations. Thromboelastometry can be a hemostatic test providing high predictive value for this condition.
authors.affiliation: Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand. Electronic address: surasak.sa@psu.ac.th.
authors.forename: Surasak
authors.initials: S
authors.lastname: Sangkhathat
authors.affiliation: Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
authors.forename: Daryth
authors.initials: D
authors.lastname: Suwannarat
authors.affiliation: Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
authors.forename: Teeranut
authors.initials: T
authors.lastname: Boonpipattanapong
authors.affiliation: Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
authors.forename: Burapat
authors.initials: B
authors.lastname: Sangthong
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D001780:Blood Coagulation Tests; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008297:Male; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013514:Surgical Procedures, Operative / Q000379:methods*; D013916:Thrombelastography / Q000379:methods*; D013997:Time Factors
keywords: Coagulopathy; Operative blood loss; Thromboelastometry