title: Validation and cross-cultural adaptation of the questionnaire ThyPRO in thyroid patients in Serbia.
abstract: BACKGRAUND/AIM: The Thyroid Specific Patient Reported Outcome Measure (ThyPRO) questionnaire is self-administered and intended to measure quality of life of thyroid patients. The aim of this study was to investigate the validity and reliability of the translated new, ThyPRO questionnaire in Serbian patients with thyroid disease.
  
  
  METHODS
  The translation process followed an internationally accepted methodology. The questionnaire was validated in 100 consecutive thyroid patients hospitalized in a tertiary level hospital, between April and August 2012. Internal reliabilities of ThyPRO scales were assesessed using Cronbach's α coefficient. Association between age, gender, education, marital and employment status, place of living, diagnosis, current treatment, hormonal status and patient quality of life were determined using Pearson's (r) and Spearman's (q) correlation coefficients.
  
  
  RESULTS
  Internal consistency and reliability for ThyPRO scales were satisfactory. Cronbach's α coefficients of 13 multi-item scales of the ThyPRO were > 0.83 (range 0.83-0.95). The scores, obtained by this questionnaire, correlated significantly with patients gender, employment status, diagnosis, current treatment and place of living. A highly significant inverse relationship was found between scores and hormonal status as well as between scores and disease duration. Patients' age, marital status and thyroid-stimulating hormone level did not influence any scale score.
  
  
  CONCLUSIONS
  The ThyPRO may be useful in measuring health-related quality of life in patients with thyroid disease in Serbia.
authors.forename: Branka
authors.initials: B
authors.lastname: Bukvić
authors.forename: Vladan
authors.initials: V
authors.lastname: Živaljević
authors.forename: Sandra
authors.initials: S
authors.lastname: Šipetić
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Diklić
authors.forename: Katarina
authors.initials: K
authors.lastname: Taušanović
authors.forename: Ivan
authors.initials: I
authors.lastname: Paunović
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D032882:Comprehension; D003466:Cultural Characteristics; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000175:diagnosis* / Q000523:psychology*; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011788:Quality of Life; D015203:Reproducibility of Results; D055771:Serbia; D011795:Surveys and Questionnaires; D062606:Tertiary Care Centers; D013963:Thyroid Hormones / Q000097:blood; D014175:Translating
chemical_list: D015415:Biomarkers; D013963:Thyroid Hormones