title: Overexpression of MAC30 is Resistant to Platinum-Based Chemotherapy in Patients With Non-Small Cell Lung Cancer.
abstract: Adjuvant platinum-based chemotherapy has developed its stability as the first-line treatment in advanced non-small cell lung cancer (NSCLC). The objective of this study was to investigate the prognostic value of meningioma-associated protein (MAC30) on adjuvant platinum-based chemotherapeutic response and survival in patients with NSCLC. A total of 174 retrospective stage III B to IV Chinese patients with NSCLC were enrolled in the study. Among all cases, 85 patients were given platinum-based chemotherapy and another 89 patients received molecularly targeted therapy. The expression of MAC30 in tumor samples was confirmed via immunohistochemical staining to correlate with the therapeutic response and survival of patients. Patients having NSCLC with MAC30 overexpression showed a poorer response to platinum-based chemotherapy, while there was no prognostic value of MAC30 expression on molecularly targeted therapy. Further, patients receiving platinum-based chemotherapy with enhanced MAC30 expression exhibited shorter survival. A multivariate analysis exhibited that increased MAC30 expression was an independent prognostic factor for overall survival in patients having NSCLC with platinum-based chemotherapy. In conclusion, patients having NSCLC with higher MAC30 expression resisted to platinum-based chemotherapy and exhibited worse survival.
authors.affiliation: Department of Respiratory Medicine, Yixing People Hospital, Affiliated Jiangsu University, China.
authors.forename: Ruhua
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, Yixing People Hospital, Affiliated Jiangsu University, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Fen
authors.affiliation: Department of Integrative Biology and Pharmacology, Medical School, The University of Texas Health Science Center at Houston, TX, USA.
authors.forename: Xubo
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Respiratory Medicine, Yixing People Hospital, Affiliated Jiangsu University, China.
authors.forename: Tieliang
authors.initials: T
authors.lastname: Ma
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, China.
authors.forename: Hourong
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of Respiratory Medicine, Yixing People Hospital, Affiliated Jiangsu University, China dh1350519@163.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D009944:Organoplatinum Compounds
keywords: MAC30; NSCLC; chemotherapy; survival