title: Insights into the nature of uranium target proteins within zebrafish gills after chronic and acute waterborne exposures.
abstract: New data on the nature of the protein targets of uranium (U) within zebrafish gills were collected after waterborne exposure, with the aim of a better understanding of U toxicity mechanisms. Some common characteristics of the U protein target binding properties were found, such as their role in the regulation of other essential metals and their phosphorus content. In total, 21 potential protein targets, including hemoglobin, are identified and discussed in terms of the literature.
authors.affiliation: Institute of Radioprotection and Nuclear Safety/PRP-ENV/SERIS - Laboratoire de Biogéochimie, Biodisponibilité et Transferts des radionucléides, Saint Paul lès Durance, France.|Laboratory of Analytical, Bio-Inorganic, and Environmental Chemistry, Pau, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bucher
authors.affiliation: Laboratory of Analytical, Bio-Inorganic, and Environmental Chemistry, Pau, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Mounicou
authors.affiliation: Institute of Radioprotection and Nuclear Safety/PRP-ENV/SERIS - Laboratoire de Biogéochimie, Biodisponibilité et Transferts des radionucléides, Saint Paul lès Durance, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Simon
authors.affiliation: Institute of Radioprotection and Nuclear Safety/PRP-ENV/SERIS - Laboratoire de Biogéochimie, Biodisponibilité et Transferts des radionucléides, Saint Paul lès Durance, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Floriani
authors.affiliation: Laboratory of Analytical, Bio-Inorganic, and Environmental Chemistry, Pau, France.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Lobinski
authors.affiliation: Institute of Radioprotection and Nuclear Safety/PRP-ENV/SERIS - Laboratoire de Biogéochimie, Biodisponibilité et Transferts des radionucléides, Saint Paul lès Durance, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Frelon
mesh_terms: D000818:Animals; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D005880:Gills / Q000187:drug effects / Q000378:metabolism*; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008970:Molecular Weight; D010758:Phosphorus / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D011506:Proteins / Q000187:drug effects*; D014501:Uranium / Q000493:pharmacokinetics / Q000633:toxicity*; D014875:Water Pollutants, Radioactive / Q000633:toxicity*; D015027:Zebrafish / Q000378:metabolism*
chemical_list: D006454:Hemoglobins; D011506:Proteins; D014875:Water Pollutants, Radioactive; D010758:Phosphorus; D014501:Uranium; D007501:Iron
keywords: Cytosol; Gills; Protein; Uranium; Zebrafish