title: Associations of immunity-related single nucleotide polymorphisms with overall survival among prostate cancer patients.
abstract: The progression of prostate cancer is influenced by systemic inflammation, and may be attributed, in part, to genetic predisposition. Single nucleotide polymorphisms associated with the immune response may help mediate prostate cancer progression. We analyzed data from a hospital-based case-control study of 164 prostate cancer patients and 157 healthy male controls from the Memorial Sloan Kettering Cancer Center. We evaluated associations between six immunity-related polymorphisms (CRP rs1205 and rs1800947, FGFR2 rs1219648 and rs2981582, IFNGR1 rs11914, and IL10 rs1800871) and overall survival among prostate cancer patients, calculating adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards regression. FGFR2 rs1219648 (GG vs. AA) and rs2981582 (TT vs. CC) polymorphisms were associated with more favorable overall survival (HR: 0.13, 95% CI: 0.03-0.62 and HR: 0.13, 95% CI: 0.03-0.53, respectively) in patients with primary prostate cancer. These observations highlight the need to validate and identify these and other immunity-related polymorphisms in larger studies examining survival of prostate cancer patients.
authors.affiliation: Department of Epidemiology, Fielding School of Public Health, University of California-Los Angeles Los Angeles, CA, USA.
authors.forename: Fayth L
authors.initials: FL
authors.lastname: Miles
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA Los Angeles, CA, USA.
authors.forename: Jian-Yu
authors.initials: JY
authors.lastname: Rao
authors.affiliation: Department of Environmental Health Sciences, Fielding School of Public Health, University of California-Los Angeles Los Angeles, CA, USA.
authors.forename: Curtis
authors.initials: C
authors.lastname: Eckhert
authors.affiliation: Department of Epidemiology, Fielding School of Public Health, University of California-Los Angeles Los Angeles, CA, USA.
authors.forename: Shen-Chih
authors.initials: SC
authors.lastname: Chang
authors.affiliation: Department of Urology, David Geffen School of Medicine at UCLA Los Angeles, CA, USA.
authors.forename: Allan
authors.initials: A
authors.lastname: Pantuck
authors.affiliation: Department of Epidemiology, Fielding School of Public Health, University of California-Los Angeles Los Angeles, CA, USA ; Jonsson Comprehensive Cancer Center, University of California-Los Angeles Los Angeles, CA, USA.
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Zhang
keywords: Genetic predisposition; case-control; immune response; polymorphisms; proportional hazards model; prostate cancer