title: An atypical presentation of colonic malignancy: Clostridium septicum aortitis.
abstract: Clostridium septicum (CS) is a rare organism that accounts for only 1.3% of all clostridial infections. However, its detection is of great clinical significance, as over 80% of cases are associated with malignancy, often occult; the most common primary sites are the ascending colon and caecum, and the most common cause is haematological malignancy. We report a case of a 79-year-old woman, admitted with shortness of breath and left-sided chest pain, who, following subsequent investigations, was found to have CS aortitis. She was further evaluated with CT of the abdomen followed by colonoscopy and biopsy, which revealed adenocarcinoma of the caecum with liver metastasis. The CS aortitis has a reported mortality of 100% if left untreated. Therefore prompt intervention and surgical debridement is recommended. Despite these recommendations, our patient had some delays in her treatment and did not undergo surgical debridement due to frailty. We believe that it is highly unusual for a patient such as ours to have survived both the aortitis and the colonic malignancy, after undergoing endovascular radiological intervention and antibiotic therapy, without surgical debridement.
authors.affiliation: Prince Charles Hospital, Merthyr Tydfil, UK.
authors.forename: Arshiya
authors.initials: A
authors.lastname: Tabasum
authors.affiliation: Department of Radiology, Cardiff and Vale University UHB, Cardiff, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Bleehen
authors.affiliation: Department of Microbiology, Cardiff and Vale University UHB, Cardiff, UK.
authors.forename: Brendan
authors.initials: B
authors.lastname: Healy
authors.affiliation: Department of Diabetes and Endocrinology, Cardiff and Vale University UHB, Cardiff, UK.
authors.forename: Lindsay
authors.initials: L
authors.lastname: George
mesh_terms: D000230:Adenocarcinoma / Q000382:microbiology / Q000473:pathology; D000368:Aged; D001025:Aortitis / Q000382:microbiology* / Q000473:pathology; D003015:Clostridium Infections / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D052557:Clostridium septicum / Q000302:isolation & purification*; D003110:Colonic Neoplasms / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000382:microbiology / Q000473:pathology / Q000556:secondary