title: Magnetic Nanoparticles in Cancer Theranostics.
abstract: In a report from 2008, The International Agency for Research on Cancer predicted a tripled cancer incidence from 1975, projecting a possible 13-17 million cancer deaths worldwide by 2030. While new treatments are evolving and reaching approval for different cancer types, the main prevention of cancer mortality is through early diagnosis, detection and treatment of malignant cell growth. The last decades have seen a development of new imaging techniques now in widespread clinical use. The development of nano-imaging through fluorescent imaging and magnetic resonance imaging (MRI) has the potential to detect and diagnose cancer at an earlier stage than with current imaging methods. The characteristic properties of nanoparticles result in their theranostic potential allowing for simultaneous detection of and treatment of the disease. This review provides state of the art of the nanotechnological applications for cancer therapy. Furthermore, it advances a novel concept of personalized nanomedical theranostic therapy using iron oxide magnetic nanoparticles in conjunction with MRI imaging. Regulatory and industrial perspectives are also included to outline future perspectives in nanotechnological cancer research.
authors.affiliation: 1. School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland ; 2. Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland ; 4. Trinity Biomedical Sciences Institute, Dublin, Ireland.
authors.forename: Oliviero L
authors.initials: OL
authors.lastname: Gobbo
authors.affiliation: 3. Department of Clinical Medicine Trinity Centre for Health Science, St. James's Hospital, Dublin, Ireland.
authors.forename: Kristine
authors.initials: K
authors.lastname: Sjaastad
authors.affiliation: 1. School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland ; 4. Trinity Biomedical Sciences Institute, Dublin, Ireland ; 5. Silesian Medical University and Kardio-Med Silesia, Zabrze, Poland.
authors.forename: Marek W
authors.initials: MW
authors.lastname: Radomski
authors.affiliation: 3. Department of Clinical Medicine Trinity Centre for Health Science, St. James's Hospital, Dublin, Ireland ; 6. Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Ireland.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Volkov
authors.affiliation: 3. Department of Clinical Medicine Trinity Centre for Health Science, St. James's Hospital, Dublin, Ireland ; 6. Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Ireland.
authors.forename: Adriele
authors.initials: A
authors.lastname: Prina-Mello
mesh_terms: D004337:Drug Carriers / Q000008:administration & dosage*; D005290:Ferric Compounds / Q000008:administration & dosage; D008280:Magnetics; D053758:Nanoparticles / Q000008:administration & dosage*; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D061848:Optical Imaging / Q000379:methods / Q000639:trends; D057285:Precision Medicine / Q000379:methods / Q000639:trends; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide
keywords: Cancer; Drug delivery; Magnetic nanoparticles; Theranostic Nanomedicine; Thermal therapy