title: Studies on lysophosphatidic acid action during in vitro preimplantation embryo development.
abstract: Assisted reproductive technologies, including in vitro embryo production (IVP), have been successfully used in animal reproduction to optimize breeding strategies for improved production and health in animal husbandry. Despite the progress in IVP techniques over the years, further improvements in in vitro embryo culture systems are required for the enhancement of oocyte and embryo developmental competence. One of the most important issues associated with IVP procedures is the optimization of the in vitro culture of oocytes and embryos. Studies in different species of animals and in humans have identified important roles for receptor-mediated lysophosphatidic acid (LPA) signaling in multiple aspects of human and animal reproductive tract function. The data on LPA signaling in the ovary and uterus suggest that LPA can directly contribute to embryo-maternal interactions via its influence on early embryo development beginning from the influence of the ovarian environment on the oocyte to the influence of the uterine environment on the preimplantation embryo. This review discusses the current status of LPA as a potential supplement in oocyte maturation, fertilization, and embryo culture media and current views on the potential involvement of the LPA signaling pathway in early embryo development.
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-748, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Boruszewska
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-748, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Sinderewicz
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-748, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Kowalczyk-Zieba
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-748, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Grycmacher
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-748, Poland. Electronic address: i.woclawek-potocka@pan.olsztyn.pl.
authors.forename: I
authors.initials: I
authors.lastname: Woclawek-Potocka
mesh_terms: D000818:Animals; D017209:Apoptosis; D001755:Blastocyst / Q000502:physiology; D003470:Culture Media; D054885:Cumulus Cells / Q000502:physiology; D046149:Embryo Culture Techniques; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques; D008246:Lysophospholipids / Q000494:pharmacology* / Q000502:physiology; D008540:Meiosis; D009865:Oocytes / Q000502:physiology; D010053:Ovary / Q000502:physiology; D049368:Receptors, Lysophosphatidic Acid / Q000502:physiology; D015398:Signal Transduction; D014599:Uterus / Q000502:physiology
chemical_list: D003470:Culture Media; D008246:Lysophospholipids; D049368:Receptors, Lysophosphatidic Acid; C032881:lysophosphatidic acid
keywords: Embryo; In vitro culture; In vitro maturation; Lysophosphatidic acid; Oocyte