title: Optic Nerve Metastasis from Squamous Cell Carcinoma of the Uterine Cervix.
abstract: Metastatic involvement of the optic nerve or its sheath is very rare (1.3 - 3%). The most common malignancies reported to metastasize to the optic nerve or its sheath are breast, lung, kidney, bladder, gastric and colorectal cancers. Carcinoma of uterine cervix metastatic to optic nerve and optic nerve sheath is extremely rare and is associated with grave prognosis due to underlying high tumor burden. Here in, we report a 61-year Saudi woman who was treated with concurrent chemoradiation for squamous cell carcinoma of cervix FIGO IVA 6 months back. She presented with pain and progressive visual loss in the right eye. Magnetic resonance imaging showed enhanced solid mass of the intraorbital optic nerve consistent with optic nerve sheath meningioma. Immunostaining (CK5/6, CAM 5.2, p63 and p16) confirmed the diagnosis of metastatic squamous cell carcinoma of uterine cervix.
authors.affiliation: Department of Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh-59046, Saudi Arabia.
authors.forename: Mutahir A
authors.initials: MA
authors.lastname: Tunio
authors.affiliation: Department of Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh-59046, Saudi Arabia.
authors.forename: Mushabbab
authors.initials: M
authors.lastname: AlAsiri
authors.affiliation: Department of Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh-59046, Saudi Arabia.
authors.forename: Khalid
authors.initials: K
authors.lastname: Riaz
authors.affiliation: Department of Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh-59046, Saudi Arabia.
authors.forename: Reham
authors.initials: R
authors.lastname: Abdulmoniem
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000473:pathology; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology; D019574:Optic Nerve Neoplasms / Q000556:secondary*; D014594:Uterine Neoplasms / Q000473:pathology*