title: Exonuclease TREX1 also Has a Sweet Tooth.
abstract: TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this issue of Immunity, Hasan et al. (2015) show that TREX1 also safeguards the cell against free glycan build-up in the endoplasmic reticulum, thereby preventing glycan-induced inflammation.
authors.affiliation: Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany; German Centre for Infection Research (DZIF), University Hospital, University of Bonn, 53127 Bonn, Germany. Electronic address: winfried.barchet@ukb.uni-bonn.de.
authors.forename: Winfried
authors.initials: W
authors.lastname: Barchet
authors.affiliation: Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Zillinger
mesh_terms: D000818:Animals; D003600:Cytosol / Q000201:enzymology*; D005090:Exodeoxyribonucleases / Q000378:metabolism*; D006602:Hexosyltransferases / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D010750:Phosphoproteins; D006602:Hexosyltransferases; D005090:Exodeoxyribonucleases