title: Interdisciplinary therapy changes superoxide dismutase activity and adiponectin in obese adolescents: a randomised controlled trial.
abstract: The objective of this study is to evaluate the effect of interdisciplinary therapy in the parameters of the oxidative stress and the anti-inflammatory responses of obese adolescents. We selected 57 participants, who were randomly divided into 2 groups: interdisciplinary therapy group and a control group. After 6 months of intervention, 17 participants of the interdisciplinary therapy group and 8 of the control group returned for re-evaluation. The interdisciplinary therapy group participated in a treatment with 4 weekly sessions of exercise, a weekly group therapy session and a weekly nutritional education session. Blood parameters of oxidative stress and anti-inflammatory response were evaluated. The results demonstrated that there were significant increases in the interdisciplinary therapy group for superoxide dismutase activity (6.56 ± 3.22 to 11.40 ± 7.49) and ferric-reducing antioxidant potential concentration (532.91 ± 106.48 to 573.25 ± 112.57), although adiponectin levels did not reduce (40.9 ± 29.34 to 49.05 ± 41.22). A significant decrease in nitrite levels was also found (14.23 ± 8.48 to 11.45 ± 6.05). In the control group, significant reduction was found in adiponectin (31.56 ± 18.88 to 18.01 ± 11.66). This study suggests that interdisciplinary therapy for 6 months was effective in improving the anti-inflammatory responses and the antioxidant defences in obese adolescents.
authors.affiliation: a Federal University of Uberlândia , Uberlândia , Brazil.
authors.forename: João Elias Dias
authors.initials: JE
authors.lastname: Nunes
authors.affiliation: a Federal University of Uberlândia , Uberlândia , Brazil.
authors.forename: Heitor Santos
authors.initials: HS
authors.lastname: Cunha
authors.affiliation: a Federal University of Uberlândia , Uberlândia , Brazil.
authors.forename: Zulmária Rezende
authors.initials: ZR
authors.lastname: Freitas
authors.affiliation: a Federal University of Uberlândia , Uberlândia , Brazil.
authors.forename: Ana Maria Caixeta
authors.initials: AM
authors.lastname: Nogueira
authors.affiliation: b Federal University of São Paulo , São Paulo , Brazil.
authors.forename: Ana Raimunda
authors.initials: AR
authors.lastname: Dâmaso
authors.affiliation: a Federal University of Uberlândia , Uberlândia , Brazil.
authors.forename: Foued Salmen
authors.initials: FS
authors.lastname: Espindola
authors.affiliation: a Federal University of Uberlândia , Uberlândia , Brazil.
authors.forename: Nadia Carla
authors.initials: NC
authors.lastname: Cheik
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism; D003376:Counseling; D004032:Diet; D015444:Exercise; D005260:Female; D006266:Health Education; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D063766:Pediatric Obesity / Q000150:complications / Q000378:metabolism / Q000523:psychology / Q000628:therapy*; D011615:Psychotherapy, Group; D012017:Referral and Consultation; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D000975:Antioxidants; D009573:Nitrites; D013482:Superoxide Dismutase
keywords: Treatment outcome; adiponectin; adolescent; inflammation; obesity; oxidative stress; superoxide dismutase