title: Focal Therapy of Prostate Cancer Using Irreversible Electroporation.
abstract: Focal therapy is a novel strategy that attempts to enhance the therapeutic ratio of standard radical treatment in prostate cancer. Irreversible electroporation (IRE) has some inherent characteristics that may be ideal for focal therapy. Precise confined ablation in the treatment area obtained via nonthermal damage with potential for minimal toxicity to surrounding structures may lead to optimal treatment with improved preservation of continence and erectile function. Initial data of focal IRE of the prostate are encouraging although further assessment is awaited to confirm these findings using robust methodology. In this article, we provide a comprehensive step-by-step description of our technique to deliver focal IRE in selected men with localized prostate cancer located in a discrete area of the prostate.
authors.affiliation: Division of Surgery and Interventional Science, University College London, London, UK; Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK; Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Electronic address: massimo.valerio.12@ucl.ac.uk.
authors.forename: Massimo
authors.initials: M
authors.lastname: Valerio
authors.affiliation: Division of Surgery and Interventional Science, University College London, London, UK; Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK.
authors.forename: Hashim U
authors.initials: HU
authors.lastname: Ahmed
authors.affiliation: Division of Surgery and Interventional Science, University College London, London, UK; Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Emberton
mesh_terms: D055011:Ablation Techniques / Q000009:adverse effects / Q000295:instrumentation; D016923:Cell Death; D038524:Diffusion Magnetic Resonance Imaging; D018274:Electroporation / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D012042:Registries; D025321:Surgery, Computer-Assisted / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D016896:Treatment Outcome
keywords: Focal therapy; Irreversible electroporation; Prostate cancer