title: Role of ((E)-(E)-4-(4-hydroxy-3-methoxyphenyl)-2-oxobut-3-en-1-yl 3-(4-hydroxy-3-methoxyphenyl) acrylate in preservation of spatial cognitive functions of rats with chronic epilepsy.
abstract: The present study demonstrates the effect of ((E)-(E)-4-(4-hydroxy-3-methoxyphenyl)-2-oxobut-3-en-1-yl 3-(4-hydroxy-3-methoxyphenyl) acrylate (CA) on spatial cognitive functions of rats with lobal cerebrovascular hypoperfusion. The bilateral common carotid arteries occlusion (2VO) surgery was performed to prepare the cerebrovascular hypoperfusion rat model. The effect of CA on spatial cognitive function was analysed using Morris water maze (MWM) test prior to and after 2VO operation. Sixty rats were randomly assigned into two groups of 30 each; long-term memory (LTM) and short-term memory (STM) groups. Both the groups were further divided into 3 subgroups: control, untreated and CA treated groups. The animals received 50 μg/kg of CA for 10 weeks of 2VO operation following which all the subgroups were tested with MWM. Both the escape latency time and total distance travelled were significantly lower for control and CA treated groups compared to untreated group revealed by working memory test. The maze test performance for control and CA treated groups was found to be improved markedly. Similarly, the results from probe memory test performance revealed significant improvement for CA treated groups compared to untreated group. Therefore, CA exhibits significant effect on the spatial cognitive preservation in rats with chronic epilepsy.
authors.affiliation: Department of Neurology, Shanghai Eighth People's Hospital Shanghai 200235, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Geng
authors.affiliation: Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine Shanghai 200235, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Lin
authors.affiliation: Department of Neurology, Shanghai Eighth People's Hospital Shanghai 200235, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Neurology, Shanghai Eighth People's Hospital Shanghai 200235, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Neurology, Shanghai Eighth People's Hospital Shanghai 200235, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Dong
authors.affiliation: Department of Neurology, Shanghai Eighth People's Hospital Shanghai 200235, China.
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Cao
authors.affiliation: Department of Neurology, Shanghai Eighth People's Hospital Shanghai 200235, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Neurology, Shanghai Eighth People's Hospital Shanghai 200235, China.
authors.forename: Xiao-Kun
authors.initials: XK
authors.lastname: Liu
keywords: Chronic epilepsy; Morris water maze; cognitive; escape latency; working memory test