title: The microbiome modulates arbovirus transmission in mosquitoes.
abstract: Mosquito-transmitted arthropod-borne viruses (arboviruses) such as dengue virus, chikungunya virus, and West Nile virus constitute a major public health burden and are increasing in severity and frequency worldwide. The microbiota associated with mosquitoes (comprised of viruses, bacteria, fungi and protozoa) can profoundly influence many host phenotypes including vector competence, which can either be enhanced or suppressed. Thus, the tripartite interactions between the mosquito vector, its microbiota and the pathogens they transmit offer novel possibilities to control arthropod-borne diseases.
authors.affiliation: Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Shivanand
authors.initials: S
authors.lastname: Hegde
authors.affiliation: Department of Entomology, Pennsylvania State University, University Park, PA 16802, USA; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA; Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Jason L
authors.initials: JL
authors.lastname: Rasgon
authors.affiliation: Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: glhughes@utmb.edu.
authors.forename: Grant L
authors.initials: GL
authors.lastname: Hughes
mesh_terms: D000818:Animals; D001102:Arbovirus Infections / Q000517:prevention & control / Q000821:virology; D001103:Arboviruses / Q000502:physiology*; D009033:Culicidae / Q000276:immunology / Q000382:microbiology* / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007303:Insect Vectors / Q000276:immunology / Q000382:microbiology* / Q000821:virology*; D056265:Microbial Interactions; D064307:Microbiota