title: Evaluation of Antileishmanial Activity of Albaha Medicinal Plants against Leishmania amazonensis.
abstract: Sixteen methanolic extracts obtained from thirteen plant species, selected either from ethnobotanical or chemotaxonomical data, were screened for their antileishmanial activity against Leishmania amazonensis. The cytotoxic activity against normal peritoneal macrophages from normal BALB/c mice was also determined. Eight extracts had IC50 values ranging from <12.5 to 37.8 µg/mL against promastigotes. Achillea biebersteinii flower, Euphorbia helioscopia, and Solanum incanum leaf extracts showed antileishmanial activities with IC50 between <12.5-26.9 µg/mL and acceptable selectivity indices of 8-5. The other leishmanicidal plant extracts, with IC50 ranging from 18.0 to 29.5 µg/mL, exhibited low selectivity indices.
authors.affiliation: Department of Biology, Faculty of Sciences, Al Baha University, Saudi Arabia.
authors.forename: Saeed S
authors.initials: SS
authors.lastname: Al-Sokari
authors.affiliation: Pharmacognosy Department, Faculty of Clinical Pharmacy, Al Baha University, Saudi Arabia.
authors.forename: Nasser A Awadh
authors.initials: NA
authors.lastname: Ali
authors.affiliation: Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba.
authors.forename: Lianet
authors.initials: L
authors.lastname: Monzote
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Aden University, P.O. Box 5411, Ma'alla, Aden, Yemen.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Al-Fatimi
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D007894:Leishmania mexicana / Q000187:drug effects*; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts