title: Predictors of No-Reflow Phenomenon in Young Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
abstract: No-reflow is of prognostic value in ST-segment elevation myocardial infarction (STEMI) but has not been extensively investigated in young patients. Young patients with STEMI admitted within 12 hours from symptom onset and treated by primary percutaneous coronary intervention (pPCI) were recruited. Patients were classified into 2 groups based on postintervention thrombolysis in myocardial infarction (TIMI) flow grade; no-reflow: TIMI flow grade 0, 1 or 2 (group 1; n = 27; 21 men, mean age: 42 ± 4 years); and angiographic success: TIMI flow grade 3 (group 2; n = 118; 110 men, mean age: 43 ± 4 years). Adjusted odds ratios were 13.79 for female gender (P < .001; confidence interval [CI] = 1.88-101.26), 2.09 for pain to balloon time (P < .017; CI = 1.14-3.812), 12.29 for high TIMI thrombus grade (P = .012; CI = 1.74-86.94), 0.04 for tirofiban use (P < .001; CI = 0.01-0.22), 5.19 for mean platelet volume (MPV; P < .001; CI = 2.44-11.01), and 1.008 for platelet-lymphocyte ratio (PLR; P = .034; CI = 1.001-1.016). In conclusion, female gender, pain to balloon time, high TIMI thrombus grade, tirofiban, MPV, and PLR were independent predictors of no-reflow in young patients with STEMI after pPCI.
authors.affiliation: Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.affiliation: Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey drsevketb@gmail.com.
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.affiliation: Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.affiliation: Department of Cardiology, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
authors.affiliation: Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aparci
authors.affiliation: Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Osman A
authors.initials: OA
authors.lastname: Yildirim
authors.affiliation: Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Demir
authors.affiliation: Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Unlu
authors.affiliation: Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Demirkol
authors.affiliation: Department of Epidemiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Kilic
authors.affiliation: Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Atila
authors.initials: A
authors.lastname: Iyisoy
mesh_terms: D000328:Adult; D000367:Age Factors; D016009:Chi-Square Distribution; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D016015:Logistic Models; D018655:Lymphocyte Count; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D054318:No-Reflow Phenomenon / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D010976:Platelet Count; D012189:Retrospective Studies; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D012737:Sex Factors; D013997:Time Factors; D061665:Time-to-Treatment; D000077466:Tirofiban; D016896:Treatment Outcome; D014443:Tyrosine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D014443:Tyrosine; D000077466:Tirofiban
keywords: ST-segment elevation myocardial infarction; female gender; pain to balloon time; primary percutaneous coronary intervention; thrombus grade; young patients