title: Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women.
abstract: OBJECTIVE
  To assess the relationship between SHBG and 18 other hormonal and metabolic parameters in well characterized, normally cycling premenopausal women.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  University general clinical research center.
  
  
  METHODS
  A total of 319 young healthy women with ovulatory menstrual cycles.
  
  
  METHODS
  None.
  
  
  METHODS
  Midfollicular serum SHBG concentrations.
  
  
  RESULTS
  In our final linear regression model, SHBG was negatively associated with bioavailable T and positively associated with adiponectin, associations that were independent from other parameters. SHBG was also positively associated with estrone sulfate, but only when taking into account confounding variables. Unexpectedly, there was no straightforward relationship between SHBG and insulin resistance according to homeostasis-model assessment.
  
  
  CONCLUSIONS
  Our results highlight the link between androgen action, as reflected by bioavailable T, and circulating SHBG concentrations in all premenopausal women and speak to the importance of the relationship between SHBG and adiponectin, which is at least in part independent from androgen action.
  
  
  BACKGROUND
  NCT00393172.
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota.
authors.forename: Talia N
authors.initials: TN
authors.lastname: Crawford
authors.affiliation: Department of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota.
authors.forename: Andrea Y
authors.initials: AY
authors.lastname: Arikawa
authors.affiliation: Department of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota.
authors.forename: Mindy S
authors.initials: MS
authors.lastname: Kurzer
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Kathryn H
authors.initials: KH
authors.lastname: Schmitz
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota. Electronic address: wphippsmd@rrc.com.
authors.forename: William R
authors.initials: WR
authors.lastname: Phipps
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004970:Estrone / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005498:Follicular Phase / Q000097:blood*; D006801:Humans; D016014:Linear Models; D015999:Multivariate Analysis; D017697:Premenopause / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D012738:Sex Hormone-Binding Globulin; D004970:Estrone; D013739:Testosterone; C017296:estrone sulfate
keywords: Sex hormone–binding globulin; adiponectin; insulin resistance; premenopause; testosterone