title: Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma.
abstract: BACKGROUND
  Trichorhinophalangeal syndrome 1 (Trps1) gene is a member of GATA transcription factor family and has an important function in tumorigenesis and progression. However, there are rare studies on its roles in carcinogenesis and prognostic significance in human osteosarcoma.
  
  
  METHODS
  The expression of Trps1 was detected by immunohistochemistry, and MVD was evaluated to determine the amounts of microvessels by counting CD31-positive endothelial cells.
  
  
  RESULTS
  Of the 74 cases that underwent study, Trps1-positive cases were 24. And it was associated with MVD significantly (P = 0.008). The data also exhibited more cases of remote metastasis (P = 0.013) and higher Enneking stage (P = 0.017) in Trps1-positive group compared to Trps1-negative group. Univariate analysis revealed that distant metastasis, MVD and Trps1 expression were associated with a lower 3-year overall survival rate and disease-free survival rate (P = 0.003, and P = 0.012 respectively). Furthermore, Trps1 and distant metastasis retained their significant prognostic effects on patients survival rate by multivariate analysis (P < 0.05).
  
  
  CONCLUSIONS
  Trps1 plays a crucial role in osteosarcoma angiogenesis, metastasis and clinical surgical stage. Trps1 can be a novel promising prognostic marker and therapeutic target, and antiangiogenic therapy which targets Trps1 molecule in patients with osteosarcoma may lead to improved prognosis and longer-term survival.
authors.affiliation: Department of Pathology, Shandong University, School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong, 250012, People's Republic of China. zhishuang2013@163.com.
authors.forename: Zhishuang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Pathology, Shandong University, School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong, 250012, People's Republic of China. li.5871899@163.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Jia
authors.affiliation: Department of Pathology, Shandong University, School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong, 250012, People's Republic of China. 984102866@qq.com.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Wu
authors.affiliation: Shandong University, School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong Province, 250012, People's Republic of China. cjj0121@163.com.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Pathology, Shandong University, School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong, 250012, People's Republic of China. 1134940542@qq.com.
authors.forename: Aifeng
authors.initials: A
authors.lastname: Pan
authors.affiliation: Department of Pathology, Shandong University, School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong, 250012, People's Republic of China. lilipathology@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001859:Bone Neoplasms / Q000098:blood supply / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002196:Capillaries / Q000737:chemistry / Q000473:pathology; D016009:Chi-Square Distribution; D004268:DNA-Binding Proteins / Q000032:analysis*; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D012516:Osteosarcoma / Q000098:blood supply / Q000737:chemistry* / Q000401:mortality / Q000556:secondary / Q000628:therapy; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D012097:Repressor Proteins; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014157:Transcription Factors / Q000032:analysis*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D012097:Repressor Proteins; C108387:TRPS1 protein, human; D014157:Transcription Factors