title: The histopathological mimics of inflammatory bowel disease: a critical appraisal.
abstract: The pathological diagnosis of inflammatory bowel disease (IBD) is often difficult because biopsy material may not contain pathognomonic features, making distinction between Crohn's disease, ulcerative colitis and other forms of colitides a truly challenging exercise. The problem is further complicated as several diseases frequently mimic the histological changes seen in IBD. Successful diagnosis is reliant on careful clinicopathological correlation and recognising potential pitfalls. This is best achieved in a multidisciplinary team setting when the full clinical history, endoscopic findings, radiology and relevant serology and microbiology are available. In this review, we present an up-to-date evaluation of the histopathological mimics of IBD.
authors.affiliation: Department of Cellular Pathology, Kings College Hospital, Denmark Hill, London, SE5 9RS, UK. Isabel.Woodman@nhs.net.
authors.forename: I
authors.initials: I
authors.lastname: Woodman
authors.affiliation: Department of Cellular Pathology, Maidstone and Tunbridge Wells NHS Trust, Maidstone, UK.
authors.forename: J B
authors.initials: JB
authors.lastname: Schofield
authors.affiliation: Department of Pathology, University Hospital of South Manchester, Manchester, UK.
authors.forename: N
authors.initials: N
authors.lastname: Haboubi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002429:Cecal Diseases / Q000382:microbiology / Q000473:pathology*; D003092:Colitis / Q000209:etiology / Q000473:pathology*; D003106:Colon / Q000098:blood supply / Q000473:pathology / Q000528:radiation effects*; D003937:Diagnosis, Differential; D004240:Diverticulum / Q000150:complications; D004749:Entamoebiasis / Q000150:complications / Q000473:pathology; D006086:Graft vs Host Disease / Q000150:complications / Q000473:pathology; D006801:Humans; D007077:Ileal Diseases / Q000382:microbiology / Q000473:pathology*; D015212:Inflammatory Bowel Diseases / Q000473:pathology*; D007511:Ischemia / Q000150:complications; D008219:Lymphogranuloma Venereum / Q000150:complications / Q000473:pathology; D008223:Lymphoma / Q000150:complications / Q000473:pathology; D019449:Pouchitis / Q000473:pathology; D011832:Radiation Injuries / Q000473:pathology*; D014385:Tuberculosis, Gastrointestinal / Q000473:pathology*; D015012:Yersinia pseudotuberculosis Infections / Q000150:complications / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: IBD; Iatrogenic colitis; Indeterminate colitis; Mimics of IBD; Non-classical; SCAD