title: Association of Non-High-Density Lipoprotein Cholesterol with Psychosocial Dysfunction in Children and Adolescents with Obesity.
abstract: BACKGROUND
  Children with obesity have worse psychosocial functioning compared to their non-overweight peers. Adult studies suggest that several metabolic factors may participate in the etiology of depression in obesity.
  
  
  METHODS
  We evaluated the association of several metabolic parameters with psychosocial dysfunction in children with obesity, through a retrospective review of electronic medical records in patients ages 6-17. All parents were asked to complete the Pediatric Symptom Checklist (PSC) questionnaire, a validated measurement of psychosocial dysfunction in children.
  
  
  RESULTS
  PSC scores were available in 618 patients. Overall, 11.2% of patients had a PSC score ≥28, suggestive of psychosocial dysfunction. Non-high-density lipoprotein (HDL) cholesterol was associated with a higher PSC score (p = 0.02), after adjusting for age, sex, race, socioeconomic status, and BMI z-score.
  
  
  CONCLUSIONS
  Consistent with adult studies, in children and adolescents with obesity, non-HDL cholesterol may play a role in the etiology of psychosocial dysfunction. Further studies are warranted.
authors.affiliation: 1 Children's Hospital Los Angeles , Los Angeles, CA.
authors.forename: Monica
authors.initials: M
authors.lastname: Serrano-Gonzalez
authors.affiliation: 2 Health Care Sciences and Family and Community Medicine, University of Texas Southwestern Medical Center , Dallas, TX.
authors.forename: Charles
authors.initials: C
authors.lastname: McConnel
authors.affiliation: 3 Cairo University School of Medicine , Cairo, Egypt .
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Bokhary
authors.affiliation: 4 Department of Pediatrics, University of Texas Southwestern Medical Center and Children's Medical Center , Dallas, TX.
authors.forename: Jon
authors.initials: J
authors.lastname: Oden
authors.affiliation: 4 Department of Pediatrics, University of Texas Southwestern Medical Center and Children's Medical Center , Dallas, TX.
authors.forename: Ximena
authors.initials: X
authors.lastname: Lopez
mesh_terms: D000293:Adolescent; D002648:Child; D002653:Child Behavior Disorders / Q000097:blood* / Q000209:etiology; D002784:Cholesterol / Q000097:blood*; D003863:Depression / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D063766:Pediatric Obesity / Q000097:blood* / Q000523:psychology*; D015995:Prevalence; D011581:Psychological Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012920:Social Behavior Disorders / Q000097:blood* / Q000209:etiology; D011795:Surveys and Questionnaires
chemical_list: D008074:Lipoproteins; C030104:lipoprotein cholesterol; D002784:Cholesterol