title: Efficacy and effectiveness of live attenuated influenza vaccine in school-age children.
abstract: Evidence of high efficacy of live attenuated influenza vaccine (LAIV) from randomized controlled trials is strong for children 2-6 years of age, but fewer data exist for older school-age children. We reviewed the published data on efficacy and effectiveness of LAIV in children ≥5 years. QUOSA (Elsevier database) was searched for articles published from January 1990 to June 2014 that included 'FluMist', 'LAIV', 'CAIV', 'cold adapted influenza vaccine', 'live attenuated influenza vaccine', 'live attenuated cold adapted' or 'flu mist'. Studies evaluated included randomized controlled trials, effectiveness and indirect protection studies. This review demonstrates that LAIV has considerable efficacy and effectiveness in school-age children.
authors.affiliation: a 1 MedImmune, Gaithersburg, MD, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Coelingh
authors.affiliation: b 2 AstraZeneca, Gaithersburg, MD, USA.
authors.forename: Ifedapo Rosemary
authors.initials: IR
authors.lastname: Olajide
authors.affiliation: a 1 MedImmune, Gaithersburg, MD, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: MacDonald
authors.affiliation: c 3 Ann & Robert Lurie Children's Hospital of Chicago, Chicago, IL, USA.
authors.forename: Ram
authors.initials: R
authors.lastname: Yogev
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D012574:Schools; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
keywords: effectiveness; efficacy; influenza vaccine; live attenuated influenza vaccine; school-age children