title: Synthesis of Novel Nucleoside Analogues Built on a Bicyclo[4.1.0]heptane Scaffold.
abstract: A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione.
authors.affiliation: Departament de Quı́mica, Universitat Autònoma de Barcelona , 08193 Bellaterra, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Domínguez-Pérez
authors.affiliation: Departament de Quı́mica, Universitat Autònoma de Barcelona , 08193 Bellaterra, Spain.
authors.forename: Éric
authors.initials: É
authors.lastname: Ferrer
authors.affiliation: Departament de Quı́mica, Universitat Autònoma de Barcelona , 08193 Bellaterra, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Figueredo
authors.affiliation: Departament de Quı́mica, Universitat Autònoma de Barcelona , 08193 Bellaterra, Spain.
authors.forename: Jean-Didier
authors.initials: JD
authors.lastname: Maréchal
authors.affiliation: Rega Institute for Medical Research, Department of Microbiology and Immunology, Katholieke Universiteit Leuven , B-3000 Leuven, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.affiliation: Departament de Quı́mica, Universitat Autònoma de Barcelona , 08193 Bellaterra, Spain.
authors.forename: Ramon
authors.initials: R
authors.lastname: Alibés
authors.affiliation: Departament de Quı́mica, Universitat Autònoma de Barcelona , 08193 Bellaterra, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Busqué
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D003512:Cyclohexanones / Q000737:chemistry*; D006536:Heptanes / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C000605824:1,4-cyclohexanedione; D001643:Bridged Bicyclo Compounds; D003512:Cyclohexanones; D006536:Heptanes; D009705:Nucleosides