title: One-cm Versus 2-cm Excision Margins for Patients With Intermediate Thickness Melanoma: A Matched-Pair Analysis.
abstract: BACKGROUND
  Optimum excision margins used in the removal of intermediate thickness melanomas remain unclear.
  
  
  OBJECTIVE
  This study's aim was to compare the clinical outcomes of 1-cm margins with 2-cm margins in patients with a tumor thickness of 1.1- to 4.0-mm.
  
  
  METHODS
  This was a retrospective study, which was based on a matched-pairs design. Equal patient cohorts were constructed in terms of gender, age, Breslow thickness, and the anatomic location of the primary lesion. There were 80 patients whom underwent an excision with a 1-cm margin and 80 patients with a 2-cm margin. Follow-up data were analyzed by the Kaplan-Meier method and a Cox regression model.
  
  
  RESULTS
  After a median follow-up time of 41 months, there were no differences in relapse-free survival or melanoma-specific survival between study groups. The wound was closed directly in 62 patients (78%) in the 1-cm group and in 36 patients (45%) in the 2-cm group (p < .001).
  
  
  CONCLUSIONS
  A 1-cm excision margin may be sufficient in melanomas of 1.1 to 2.0 mm in Breslow thickness based on these findings of low recurrence. With thicker tumors (2.1-4.0 mm), this recommendation cannot be given due to inherent study limitations.
authors.affiliation: Departments of *General and Plastic Surgery, and †Oncology, Turku University Hospital, Turku, Finland.
authors.forename: Ilkka
authors.initials: I
authors.lastname: Koskivuo
authors.forename: Salvatore
authors.initials: S
authors.lastname: Giordano
authors.forename: Esko
authors.initials: E
authors.lastname: Veräjänkorva
authors.forename: Pia
authors.initials: P
authors.lastname: Vihinen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008545:Melanoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult