title: Therapeutic interventions in parkinsonism: Corticobasal degeneration.
abstract: Corticobasal degeneration (CBD) is a progressive neurodegenerative disorder resulting from pathological accumulation of tau protein and is included in the spectrum of Atypical Parkinsonism. The typical clinical phenotype of CBD is characterized by the Corticobasal syndrome (CBS). In recent years it has become clear that the clinical picture of CBS may be caused by different pathological conditions, resulting in frequent misdiagnosis. CBD has high morbidity and poor prognosis with no effective therapies. In this review, we will discuss the symptomatic treatment, the palliative care and the disease modifying strategies currently in use. Symptomatic treatment in patients with CBD may sometimes be useful for improving motor (parkinsonism, dystonia and myoclonus) and non-motor (cognitive-behavioral) symptoms, but the effects are often unsatisfactory. In addition, non-pharmacological strategies and palliative care are useful integrating components of the multidisciplinary therapeutic approach for patients with CBD. Despite many efforts, a disease-modifying treatment is still unavailable for CBD.
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Marsili
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy; Neuromed Institute, "Sapienza" University of Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Suppa
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy; Neuromed Institute, "Sapienza" University of Rome, Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Berardelli
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy. Electronic address: carlo.colosimo@uniroma1.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Colosimo
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000473:pathology*; D001480:Basal Ganglia Diseases / Q000175:diagnosis / Q000628:therapy; D001521:Behavior Therapy / Q000379:methods / Q000639:trends; D002540:Cerebral Cortex / Q000473:pathology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000628:therapy*; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000628:therapy*
keywords: Corticobasal degeneration; Corticobasal syndrome; Dementia; Dopaminergic therapy; Parkinsonism