title: Liver Steatosis Assessed by Controlled Attenuation Parameter (CAP) Measured with the XL Probe of the FibroScan: A Pilot Study Assessing Diagnostic Accuracy.
abstract: To assess liver steatosis, the controlled attenuation parameter (CAP; giving an estimate of ultrasound attenuation ∼3.5 MHz) is available with the M probe of the FibroScan. We report on the adaptation of the CAP for the FibroScan XL probe (center frequency 2.5 MHz) without modifying the range of values (100-400 dB/m). CAP validation was successfully performed on Field II simulations and on tissue-mimicking phantoms. In vivo performance was assessed in a cohort of 59 patients spanning the range of steatosis. In vivo reproducibility was good and similar with both probes. The area under receiver operative characteristic curve was equal to 0.83/0.84 and 0.92/0.91 for the M/XL probes to detect >2% and >16% liver fat, respectively, as assessed by magnetic resonance imaging. Patients can now be assessed simultaneously for steatosis and fibrosis using the FibroScan, regardless of their morphology.
authors.affiliation: R&D Department, Echosens, Paris, France. Electronic address: magali.sasso@echosens.com.
authors.forename: Magali
authors.initials: M
authors.lastname: Sasso
authors.affiliation: R&D Department, Echosens, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Audière
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Centre de Référence Maladies Rares des Maladies Inflammatoires des Voies Biliaires, et Service d'hépatologie, Centre de Recherche Saint-Antoin, Sorbonne Université, Paris, France.
authors.forename: Astrid
authors.initials: A
authors.lastname: Kemgang
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Centre de Référence Maladies Rares des Maladies Inflammatoires des Voies Biliaires, et Service d'hépatologie, Centre de Recherche Saint-Antoin, Sorbonne Université, Paris, France.
authors.forename: Farid
authors.initials: F
authors.lastname: Gaouar
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Centre de Référence Maladies Rares des Maladies Inflammatoires des Voies Biliaires, et Service d'hépatologie, Centre de Recherche Saint-Antoin, Sorbonne Université, Paris, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Corpechot
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Centre de Référence Maladies Rares des Maladies Inflammatoires des Voies Biliaires, et Service d'hépatologie, Centre de Recherche Saint-Antoin, Sorbonne Université, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Chazouillères
authors.affiliation: Medical Affairs Department, Echosens, Paris, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Fournier
authors.affiliation: Department of Radiology, Hôpital Saint-Antoine, APHP, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Golsztejn
authors.affiliation: Department of Radiology, Hôpital Saint-Antoine, APHP, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Prince
authors.affiliation: Department of Radiology, Hôpital Saint-Antoine, APHP, Paris, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Menu
authors.affiliation: R&D Department, Echosens, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Sandrin
authors.affiliation: R&D Department, Echosens, Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Miette
mesh_terms: D019540:Area Under Curve; D015331:Cohort Studies; D005234:Fatty Liver / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D010865:Pilot Projects; D012372:ROC Curve; D015203:Reproducibility of Results; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods*
keywords: Controlled attenuation parameter (CAP); Elastography; FibroScan; Liver; Non-alcoholic fatty liver disease (NAFLD); Steato-hepatitis; Steatosis; Ultrasound attenuation; Vibration-controlled transient elastography (VCTE)