title: [What Can Study of Oligomerization of Proteins in the Process of Oncogenesis Bring Us?].
abstract: Many cellular proteins form oligomers. The equilibrium between monomeric and oligomeric states of these proteins is important for the regulation of protein activity. Modulation of the oligomerization equilibrium could be an interesting approach in the development of new therapeutic agents. This review summarizes information about protein oligomerization and modulation of this process, demonstrating the role of oligomerization in oncogenesis by tumor suppressor protein p53, which forms tetrameric structure. Today, many studies focus on finding compounds that stabilize its tetramers. Among the methods for studying oligomerization, we present hydrogen/ deuterium exchange method coupled with mass spectrometry which is suitable for the detection of protein-protein interaction and analysis of oligomerization dynamics.
authors.forename: D
authors.initials: D
authors.lastname: Coufalová
authors.forename: B
authors.initials: B
authors.lastname: Vojtěšek
authors.forename: L
authors.initials: L
authors.lastname: Hernychová
mesh_terms: D063646:Carcinogenesis; D041961:Deuterium Exchange Measurement; D015195:Drug Design; D006801:Humans; D013058:Mass Spectrometry; D055503:Protein Multimerization; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
chemical_list: D016159:Tumor Suppressor Protein p53