title: [Skin aging: Molecular understanding of extrinsic and intrinsic processes].
abstract: In an ever-aging society, a better understanding of the underlying mechanisms accompanying skin aging has become essential. Most age-related morphological skin changes are triggered by a combination of intrinsic factors (e.g., genetics, hormones) and extrinsic ones (e.g., ultarviolet/infrared light exposure, smoking, pollution). In this article, new insights on the latest findings regarding the pathogenesis of skin aging are summarised, addressing the extent to which the aforementioned factorsmay influence the progress of skin aging and identifying the consequences on the morphology and physiology of skin.
authors.affiliation: Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Life Science Building N27, James-Franck Ring/Meyerhofstraße 11c, 89081, Ulm, Deutschland. evgenia.makrantonaki@uni-ulm.de.|Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland. evgenia.makrantonaki@uni-ulm.de.|Forschungsgruppe Geriatrie, Charité Universitätsmedizin Berlin, Reinickendorferstr. 61, 13347, Berlin, Deutschland. evgenia.makrantonaki@uni-ulm.de.
authors.forename: E
authors.initials: E
authors.lastname: Makrantonaki
authors.affiliation: Institut für Molekulare Medizin, Universität Ulm, Life Science Building N27, James-Franck Ring/Meyerhofstraße 11c, 89081, Ulm, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Vogel
authors.affiliation: Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Life Science Building N27, James-Franck Ring/Meyerhofstraße 11c, 89081, Ulm, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Scharffetter-Kochanek
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland.
authors.forename: C C
authors.initials: CC
authors.lastname: Zouboulis
mesh_terms: D065638:Absorption, Radiation / Q000502:physiology*; D000818:Animals; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D015595:Skin Aging / Q000473:pathology* / Q000502:physiology* / Q000528:radiation effects; D012907:Smoking / Q000503:physiopathology*
chemical_list: D006728:Hormones
keywords: Environment; Genetics; Hormones; Prevention; Smoking