title: Refractive status and optical components of premature babies with or without retinopathy of prematurity at 3-4 years old.
abstract: OBJECTIVE
  To investigate the refractive status and optical components of premature babies with or without retinopathy of prematurity (ROP) at 3-4 years old, and to explore the influence of prematurity and ROP on the refractive status and optical components.
  
  
  METHODS
  Premature babies receiving fundus examination were recruited into ROP group and non-ROP group, with age-matched full-term babies as controls.
  
  
  RESULTS
  The incidence of myopia was the highest in ROP (3/59, 5.08%). The incidence of astigmatism was significantly different between ROP (37.29%, 22/59) and controls (17.86%, 15/84). The corneal refractive power in ROP and non-ROP was more potent compared with controls (P<0.05); corneal curvature was steeper (P<0.05); lens thickness was thinner (P<0.05); ocular axial length was shorter P<0.05). The gestational age was negatively related to corneal astigmatism and astigmatism, positively associated with vitreous thickness and axial length. The birth-weight was negatively associated with corneal astigmatism, astigmatism and corneal refractive power, positively related to corneal radius of curvature, vitreous thickness and ocular axial length.
  
  
  CONCLUSIONS
  Premature babies with or without ROP are susceptible to myopia and astigmatism. ROP, prematurity and low birth-weight synergistically influence the development of refractive status and optical components, of which the prematurity and low birth-weight are more important.
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Ouyang
authors.affiliation: Department of Ophthalmology, Southwest Hospital, The 3rd Army Medical University Chongqing 400038, China.
authors.forename: Zheng-Qin
authors.initials: ZQ
authors.lastname: Yin
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ke
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Xin-Ke
authors.initials: XK
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Xiu-Rong
authors.initials: XR
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Ophthalmology, Children's Hospital, Chongqing Medical University Chongqing 400014, China.
authors.forename: Lian-Hong
authors.initials: LH
authors.lastname: Pi
keywords: Prematurity; low birth-weight; optical components; refractive status; retinopathy of prematurity