title: Nutrient Competition: A New Axis of Tumor Immunosuppression.
abstract: It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.
authors.affiliation: Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health Bethesda, MD 20892, USA.
authors.forename: Madhusudhanan
authors.initials: M
authors.lastname: Sukumar
authors.affiliation: Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health Bethesda, MD 20892, USA.
authors.forename: Rahul
authors.initials: R
authors.lastname: Roychoudhuri
authors.affiliation: Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health Bethesda, MD 20892, USA. Electronic address: restifo@nih.gov.
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Restifo
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D006019:Glycolysis; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology* / Q000378:metabolism*; D008545:Melanoma / Q000276:immunology* / Q000628:therapy*; D015166:Monitoring, Immunologic; D009369:Neoplasms / Q000378:metabolism*; D010728:Phosphoenolpyruvate / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D010728:Phosphoenolpyruvate