title: How Center Volumes Affect Early Outcomes in Acute Myeloid Leukemia.
abstract: Early mortality (EM) is all too frequent during induction chemotherapy for acute myeloid leukemia. Older patients shoulder an undue amount of this burden as a result of the inherent biology of their disease and increased comorbidities. EM rates in academic centers have seen a sharp decline over the past 20 years; however, data from population-based registries show that EM rates for the general population have significantly lagged behind. In this review, we analyze the data available on EM in academic centers and the general population, explore recent improvements in supportive care and the use of predictive models, and finally investigate the relationship between case volume and complications during chemotherapy.
authors.affiliation: Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN. Electronic address: ahahn100@gmail.com.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Hahn
authors.affiliation: Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN.
authors.forename: Omer
authors.initials: O
authors.lastname: Jamy
authors.affiliation: Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN.
authors.forename: Sara
authors.initials: S
authors.lastname: Nunnery
authors.affiliation: Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN; Department of Hematology/Oncology, The West Cancer Center, Memphis, TN.
authors.forename: George
authors.initials: G
authors.lastname: Yaghmour
authors.affiliation: Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN.
authors.forename: Smith
authors.initials: S
authors.lastname: Giri
authors.affiliation: Department of Internal Medicine, Reading Health System, West Reading, PA.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Pathak
authors.affiliation: Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN; Department of Hematology/Oncology, The West Cancer Center, Memphis, TN.
authors.forename: Mike G
authors.initials: MG
authors.lastname: Martin
mesh_terms: D000046:Academic Medical Centers / Q000706:statistics & numerical data; D000367:Age Factors; D015897:Comorbidity; D019468:Disease Management; D006801:Humans; D015994:Incidence; D007239:Infections / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D008962:Models, Theoretical; D009026:Mortality; D017063:Outcome Assessment, Health Care; D011159:Population Surveillance; D011787:Quality of Health Care
keywords: Academic center and population data; Early mortality; Geriatric assessments; Predictive models; Supportive care