title: Helikaurolides A-D with a Diterpene-Sesquiterpene Skeleton from Supercritical Fluid Extracts of Helianthus annuus L. var. Arianna.
abstract: Four novel compounds (1-4) with an unprecedented skeleton that combines a sesquiterpene lactone and a kaurane diterpene acid were isolated from Helianthus annuus L. var. Arianna extract, which was obtained under supercritical conditions. The structures of 1-4 were elucidated by NMR and MS analyses. The biosynthetic routes involve sesquiterpene lactones and kauranic acid, both of which were previously isolated from this species.
authors.affiliation: Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO) and ‡Department of Chemical Engineering and Food Technology, Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz , C/República Saharaui 7, 11510 Puerto Real, Cádiz, Spain.
authors.forename: Ascensión
authors.initials: A
authors.lastname: Torres
authors.affiliation: Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO) and ‡Department of Chemical Engineering and Food Technology, Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz , C/República Saharaui 7, 11510 Puerto Real, Cádiz, Spain.
authors.forename: José M G
authors.initials: JM
authors.lastname: Molinillo
authors.affiliation: Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO) and ‡Department of Chemical Engineering and Food Technology, Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz , C/República Saharaui 7, 11510 Puerto Real, Cádiz, Spain.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Varela
authors.affiliation: Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO) and ‡Department of Chemical Engineering and Food Technology, Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz , C/República Saharaui 7, 11510 Puerto Real, Cádiz, Spain.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Casas
authors.affiliation: Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO) and ‡Department of Chemical Engineering and Food Technology, Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz , C/República Saharaui 7, 11510 Puerto Real, Cádiz, Spain.
authors.forename: Casimiro
authors.initials: C
authors.lastname: Mantell
authors.affiliation: Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO) and ‡Department of Chemical Engineering and Food Technology, Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz , C/República Saharaui 7, 11510 Puerto Real, Cádiz, Spain.
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Martínez de la Ossa
authors.affiliation: Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO) and ‡Department of Chemical Engineering and Food Technology, Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz , C/República Saharaui 7, 11510 Puerto Real, Cádiz, Spain.
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Macías
mesh_terms: D001826:Body Fluids; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D006368:Helianthus / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D004224:Diterpenes; D007783:Lactones; D012717:Sesquiterpenes