title: [Is it possible to cure HIV infection?].
abstract: Antiretroviral therapy has significantly improved the life expectancy in HIV-infected people, but it cannot cure the disease by itself. Several barriers have been identified for the cure of HIV infection, including a reservoir of latently infected cells, persistent viral replication in tissues, and anatomical sanctuaries. The main strategy proposed for the cure of HIV consists on the administration of drugs that, through the reactivation of latent HIV, would eliminate the cell reservoir. Ongoing clinical trials have shown the proof of concept, but the efficacy of these drugs in decreasing the reservoir size has not been proved so far.
authors.forename: Carolina
authors.initials: C
authors.lastname: Gutiérrez
authors.forename: Nadia P
authors.initials: NP
authors.lastname: Madrid
authors.affiliation: Santiago Moreno, Servicio de Enfermedades Infecciosas. Hospital Universitario Ramón y Cajal Carretera de Colmenar, Km. 9,100 - 28034, Madrid, Spain. smguillen@salud.madrid.org.
authors.forename: Santiago
authors.initials: S
authors.lastname: Moreno
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods* / Q000639:trends; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents