title: Measuring the Potential Impact of Combination HIV Prevention in Sub-Saharan Africa.
abstract: A public health approach to combination HIV prevention is advocated to contain the epidemic in sub-Saharan Africa. We explore the implications of universal access to treatment along with HIV education scale-up in the region. We develop an HIV transmission model to investigate the impacts of universal access to treatment, as well as an analytical framework to estimate the effects of HIV education scale-up on the epidemic. We calibrate the model with data from South Africa and simulate the impacts of universal access to treatment along with HIV education scale-up on prevalence, incidence, and HIV-related deaths over a course of 15 years. Our results show that the impact of combined interventions is significantly larger than the summation of individual intervention impacts (super-additive property). The combined strategy of universal access to treatment and HIV education scale-up decreases the incidence rate by 74% over the course of 15 years, whereas universal access to treatment and HIV education scale up will separately decrease that by 43% and 8%, respectively. Combination HIV prevention could be notably effective in transforming HIV epidemic to a low-level endemicity. Our results suggest that in designing effective combination prevention in sub-Saharan Africa, priorities should be given to achieving universal access to treatment as quickly as possible and improving compliance to condom use.
authors.affiliation: From the Department of Industrial Engineering, Clemson University, Clemson (AK, SA); and Anmed Health Medical Center, Anderson, South Carolina, USA (DP).
authors.forename: Amin
authors.initials: A
authors.lastname: Khademi
authors.forename: Sunanth
authors.initials: S
authors.lastname: Anand
authors.forename: David
authors.initials: D
authors.lastname: Potts
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D006266:Health Education; D006801:Humans; D008962:Models, Theoretical