title: TGF-β1-509C/T polymorphism and the risk of ESCC in a Chinese Han population.
abstract: BACKGROUND
  The studies investigating whether transforming growth factor (TGF)-β1-509C/T polymorphism is associated with the risk of ESCC is inconsistent.
  
  
  METHODS
  The TGF-β1-509C/T genotypes were determined by using a polymerase chain reaction (PCR)-restriction fragment length polymorphism assay and DNA sequencing analysis. The differences in demographic variables and genotype distributions of TGF-β1-509C/T polymorphism between ESCC patients and controls were calculated by Pearson's Chi square test. Associations between TGF-β1-509C/T polymorphism genotypes and ESCC risk were estimated by OR and their 95% CIs computed using unconditional logistic regression model.
  
  
  RESULTS
  There was a significant difference of TGF-β1-509C/T polymorphism genotype distribution between ESCC group and control group (P<0.001). With the CC genotype as reference, the adjusted OR for CT genotype reached to 0.78 (95% CI: 0.65-0.89; P=0.041), and the adjusted OR for TT homozygous carriers was 0.52 (95% CI: 0.33-0.78; P=0.017). The T allele carriage also presented a lower risk for ESCC (adjusted OR=0.43; 95% CI, 0.29-0.71; P=0.009).
  
  
  CONCLUSIONS
  TGF-β1-509C/T polymorphism may contributes to ESCC susceptibility in Chinese population.
authors.affiliation: Department of Thoracic Surgery, Binzhou Medical College Hospital Binzhou 256603, Shandong, China.
authors.forename: Hong-Jian
authors.initials: HJ
authors.lastname: Liu
authors.affiliation: Department of Thoracic Surgery, Binzhou Medical College Hospital Binzhou 256603, Shandong, China.
authors.forename: Qing-Guang
authors.initials: QG
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Binzhou Medical College Hospital Binzhou 256603, Shandong, China.
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Binzhou Medical College Hospital Binzhou 256603, Shandong, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Xu
authors.affiliation: Department of Thoracic Surgery, Binzhou Medical College Hospital Binzhou 256603, Shandong, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhang
keywords: ESCC; TGF-β1; polymorphism; risk