title: Extracellular Vesicles: Role in Inflammatory Responses and Potential Uses in Vaccination in Cancer and Infectious Diseases.
abstract: Almost all cells and organisms release membrane structures containing proteins, lipids, and nucleic acids called extracellular vesicles (EVs), which have a wide range of functions concerning intercellular communication and signaling events. Recently, the characterization and understanding of their biological role have become a main research area due to their potential role in vaccination, as biomarkers antigens, early diagnostic tools, and therapeutic applications. Here, we will overview the recent advances and studies of Evs shed by tumor cells, bacteria, parasites, and fungi, focusing on their inflammatory role and their potential use in vaccination and diagnostic of cancer and infectious diseases.
authors.affiliation: Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Biológicas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, 09913-030 São Paulo, SP, Brazil.
authors.forename: João Henrique
authors.initials: JH
authors.lastname: Campos
authors.affiliation: Laboratório de Parasitologia Celular e Molecular, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, 30190-002 Belo Horizonte, MG, Brazil.
authors.forename: Rodrigo Pedro
authors.initials: RP
authors.lastname: Soares
authors.affiliation: Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Biológicas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, 09913-030 São Paulo, SP, Brazil.
authors.forename: Kleber
authors.initials: K
authors.lastname: Ribeiro
authors.affiliation: Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Biológicas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, 09913-030 São Paulo, SP, Brazil.
authors.forename: André Cronemberger
authors.initials: AC
authors.lastname: Andrade
authors.affiliation: Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Biológicas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, 09913-030 São Paulo, SP, Brazil.
authors.forename: Wagner Luiz
authors.initials: WL
authors.lastname: Batista
authors.affiliation: Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Biológicas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, 09913-030 São Paulo, SP, Brazil.
authors.forename: Ana Claudia
authors.initials: AC
authors.lastname: Torrecilhas
mesh_terms: D000818:Animals; D002450:Cell Communication; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000209:etiology* / Q000378:metabolism*; D000067128:Extracellular Vesicles / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000628:therapy; D015398:Signal Transduction; D014611:Vaccination