title: Primo Vascular System: An Endothelial-to-Mesenchymal Potential Transitional Tissue Involved in Gastric Cancer Metastasis.
abstract: Gastric cancer is the fourth commonest cancer in the world and the second leading cause of cancer-related death. Investigation of gastric cancer metastasis is one of the hottest and major focuses in cancer research. Growing evidence manifested that primo vascular system (PVS) is a new kind of circulatory system beyond vascular and lymphatic system. Previous researches revealed that PVS is a specific tissue between endothelium and mesenchyme and is involved in cancer, especially in tumor metastasis and regeneration. In current study, we investigated the role of primo vessels in gastric cancer metastasis and its possible relationship to vascular vessels formation. Our results indicated that primo vessels were involved in gastric cancer metastasis. We observed blood vessel-mediated metastasis, primo vessel-mediated metastasis, and an intermediate state between them. We deduced that primo vessels may be precursors of blood vessels. These results possibly provided a thoroughly new theoretic development in cancer metastasis.
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430070, China.
authors.forename: An
authors.initials: A
authors.lastname: Ping
authors.affiliation: Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Su
authors.initials: S
authors.lastname: Zhendong
authors.affiliation: Department of Anatomy, Southern Medical University, Guangzhou 510515, China.
authors.forename: Qu
authors.initials: Q
authors.lastname: Rongmei
authors.affiliation: Department of Anatomy, Southern Medical University, Guangzhou 510515, China.
authors.forename: Dai
authors.initials: D
authors.lastname: Jingxing
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430070, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wei
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430070, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhongyin
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430070, China.
authors.forename: Luo
authors.initials: L
authors.lastname: Hesheng
authors.affiliation: Nano Primo Research Center, Advanced Institute of Convergence Technology, Seoul National University, Suwon-si 443-270, Republic of Korea.
authors.forename: Kwang-Sup
authors.initials: KS
authors.lastname: Soh