title: Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction.
abstract: Cardiac cell therapy is a strategy to treat patients with chronic myocardial infarction (MI). No consensus exists regarding the optimal cell type. First, a comparison between autologous bone marrow-derived mononuclear cells (BMMNC) and mesenchymal stem cells (MSC) on therapeutic efficacy after MI was performed. Next, the effect of repetitive, NOGA-guided transendocardial injection was determined via a crossover design. Nineteen pigs were allocated in three groups: (1) placebo (at 4 and 8 weeks), (2) MSC (followed by placebo at 8 weeks), or (3) BMMNC (followed by MSC at 8 weeks) delivery including a priming strategy to enhance MSC effect. At 4 weeks, ejection fraction (EF) was significantly improved after MSC injection and not by BMMNC injection. After 8 weeks, no difference was observed in EF between cell-treated groups demonstrating the positive systolic effect of MSC. This study showed that MSC rather than BMMNC injection improves systolic function in chronic MI.
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors.forename: T I G
authors.initials: TI
authors.lastname: van der Spoel
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors.forename: W A
authors.initials: WA
authors.lastname: Gathier
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Koudstaal
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: van Slochteren
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors.forename: S Jansen
authors.initials: SJ
authors.lastname: Of Lorkeers
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.|Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands.
authors.forename: J P G
authors.initials: JP
authors.lastname: Sluijter
authors.affiliation: Department of Experimental Cardiology, Utrecht, The Netherlands.
authors.forename: I E
authors.initials: IE
authors.lastname: Hoefer
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Steendijk
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors.forename: M J M
authors.initials: MJ
authors.lastname: Cramer
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.|Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands.
authors.forename: P A
authors.initials: PA
authors.lastname: Doevendans
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: van Belle
authors.affiliation: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. s.a.j.chamuleau@umcutrecht.nl.
authors.forename: S A J
authors.initials: SA
authors.lastname: Chamuleau
mesh_terms: D000771:Anesthesia, Intravenous; D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods; D002478:Cells, Cultured; D002908:Chronic Disease; D004195:Disease Models, Animal; D004452:Echocardiography; D005260:Female; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D009203:Myocardial Infarction / Q000503:physiopathology / Q000601:surgery*; D011292:Premedication; D013318:Stroke Volume; D013552:Swine; D013599:Systole / Q000502:physiology; D014182:Transplantation, Autologous
keywords: Ischemic cardiomyopathy; Mesenchymal stem cell; Stem cells; Systolic function