title: Role of bacteria in leukocyte adhesion deficiency-associated periodontitis.
abstract: Leukocyte adhesion deficiency Type I (LAD-I)-associated periodontitis is an aggressive form of inflammatory bone loss that has been historically attributed to lack of neutrophil surveillance of the periodontal infection. However, this form of periodontitis has proven unresponsive to antibiotics and/or mechanical removal of the tooth-associated biofilm. Recent studies in LAD-I patients and relevant animal models have shown that the fundamental cause of LAD-I periodontitis involves dysregulation of a granulopoietic cytokine cascade. This cascade includes interleukin IL-23 (IL-23) and IL-17 that drive inflammatory bone loss in LAD-I patients and animal models and, moreover, foster a nutritionally favorable environment for bacterial growth and development of a compositionally unique microbiome. Although the lack of neutrophil surveillance in the periodontal pockets might be expected to lead to uncontrolled bacterial invasion of the underlying connective tissue, microbiological analyses of gingival biopsies from LAD-I patients did not reveal tissue-invasive infection. However, bacterial lipopolysaccharide was shown to translocate into the lesions of LAD-I periodontitis. It is concluded that the bacteria serve as initial triggers for local immunopathology through translocation of bacterial products into the underlying tissues where they unleash the dysregulated IL-23-IL-17 axis. Subsequently, the IL-23/IL-17 inflammatory response sustains and shapes a unique local microbiome which, in turn, can further exacerbate inflammation and bone loss in the susceptible host.
authors.affiliation: Department of Microbiology, University of Pennsylvania Penn Dental Medicine, Philadelphia, PA 19104, USA. Electronic address: geoh@upenn.edu.
authors.forename: George
authors.initials: G
authors.lastname: Hajishengallis
authors.affiliation: Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA. Electronic address: nmoutsopoulos@dir.nidr.nih.gov.
authors.forename: Niki M
authors.initials: NM
authors.lastname: Moutsopoulos
mesh_terms: D016301:Alveolar Bone Loss / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D000818:Animals; D018407:Bacterial Physiological Phenomena; D005881:Gingiva / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D053759:Interleukin-23 / Q000276:immunology; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008070:Lipopolysaccharides; D009504:Neutrophils / Q000276:immunology; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D011862:Radiography, Panoramic
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17; D053759:Interleukin-23; D008070:Lipopolysaccharides
keywords: IL-17; IL-23; Inflammation; Leukocyte adhesion deficiency; Microbiota; Periodontitis