title: Enantiospecific C-H Activation Using Ruthenium Nanocatalysts.
abstract: The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.
authors.affiliation: CEA Saclay, SCBM, iBiTec-S, Building 547, PC # 108, 91191 Gif sur Yvette (France).
authors.forename: Céline
authors.initials: C
authors.lastname: Taglang
authors.affiliation: LPCNO; Laboratoire de Physique et Chimie de Nano-Objets, UMR 5215 INSA-CNRS-UPS, Institut National des Sciences Appliquées, 135, Avenue de Rangueil, 31077 Toulouse (France).|CNRS; LCC (Laboratoire de Chimie de Coordination), 205, Route de Narbonne, 31077 Toulouse (France).
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Martínez-Prieto
authors.affiliation: LPCNO; Laboratoire de Physique et Chimie de Nano-Objets, UMR 5215 INSA-CNRS-UPS, Institut National des Sciences Appliquées, 135, Avenue de Rangueil, 31077 Toulouse (France).
authors.forename: Iker
authors.initials: I
authors.lastname: del Rosal
authors.affiliation: LPCNO; Laboratoire de Physique et Chimie de Nano-Objets, UMR 5215 INSA-CNRS-UPS, Institut National des Sciences Appliquées, 135, Avenue de Rangueil, 31077 Toulouse (France).
authors.forename: Laurent
authors.initials: L
authors.lastname: Maron
authors.affiliation: LPCNO; Laboratoire de Physique et Chimie de Nano-Objets, UMR 5215 INSA-CNRS-UPS, Institut National des Sciences Appliquées, 135, Avenue de Rangueil, 31077 Toulouse (France).
authors.forename: Romuald
authors.initials: R
authors.lastname: Poteau
authors.affiliation: CNRS; LCC (Laboratoire de Chimie de Coordination), 205, Route de Narbonne, 31077 Toulouse (France).
authors.forename: Karine
authors.initials: K
authors.lastname: Philippot
authors.affiliation: LPCNO; Laboratoire de Physique et Chimie de Nano-Objets, UMR 5215 INSA-CNRS-UPS, Institut National des Sciences Appliquées, 135, Avenue de Rangueil, 31077 Toulouse (France).
authors.forename: Bruno
authors.initials: B
authors.lastname: Chaudret
authors.affiliation: CEA Saclay, SCBM, iBiTec-S, Building 547, PC # 108, 91191 Gif sur Yvette (France).
authors.forename: Serge
authors.initials: S
authors.lastname: Perato
authors.affiliation: CEA Saclay, SCBM, iBiTec-S, Building 547, PC # 108, 91191 Gif sur Yvette (France).
authors.forename: Anaïs
authors.initials: A
authors.lastname: Sam Lone
authors.affiliation: CEA Saclay, SCBM, iBiTec-S, Building 547, PC # 108, 91191 Gif sur Yvette (France).
authors.forename: Céline
authors.initials: C
authors.lastname: Puente
authors.affiliation: CEA Saclay, SCBM, iBiTec-S, Building 547, PC # 108, 91191 Gif sur Yvette (France).
authors.forename: Christophe
authors.initials: C
authors.lastname: Dugave
authors.affiliation: CEA Saclay, SCBM, iBiTec-S, Building 547, PC # 108, 91191 Gif sur Yvette (France).
authors.forename: Bernard
authors.initials: B
authors.lastname: Rousseau
authors.affiliation: CEA Saclay, SCBM, iBiTec-S, Building 547, PC # 108, 91191 Gif sur Yvette (France). gregory.pieters@cea.fr.
authors.forename: Grégory
authors.initials: G
authors.lastname: Pieters
keywords: CH activation; ab initio calculations; deuterium; isotopic labeling; nanoparticles