title: A meta-analysis of glutathione S-transferase M1 and T1 genetic polymorphism in relation to susceptibility to nasopharyngeal carcinoma.
abstract: OBJECTIVE
  To investigate the relationship between glutathione S-transferase M1 (GSTM1), and T1 (GSTT1) genetic polymorphism and susceptibility to nasopharyngeal carcinoma (NPC) using meta-analysis method.
  
  
  METHODS
  Data of published case-control studies on the relationship between GSTT1, GSTM1 genetic polymorphism and susceptibility to NPC were collected from EMBASE, PubMed, Web of Science, China Academic Journals Full-text Database, Chinese Biomedical Literature Database, and Wanfang Database. Meta-analysis was conducted using Revman 5.2 software.
  
  
  RESULTS
  Nine studies were included for meta-analysis with a total of 1295 cases of NPC patients and 1967 control individuals. Meta-analysis showed that the risk of NPC was significantly higher in population with GSTM1 gene deletion (OR=1.43, 95% CI: 1.42-1.65; P<0.001). Similarly, the risk of NPC was significantly higher in Chinese population with GSTM1 gene deletion (OR=1.38, 95% CI: 1.18-1.62; P<0.001). We did not find association between GSTT1 gene deletion and NPC risk not only in total population (OR=1.32, 95% CI: 0.92-1.87; P=0.12), but in Chinese population (OR=1.41, 95% CI: 0.97-2.04; P=0.07).
  
  
  CONCLUSIONS
  GSTM1 genetic polymorphism, but GSTT1, is associated with susceptibility to NPC.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Liu
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
authors.forename: Ji-Chuan
authors.initials: JC
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
authors.forename: Ming-Dong
authors.initials: MD
authors.lastname: Li
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
authors.forename: Te
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
keywords: Glutathione S-transferase; genetic susceptibility; nasopharyngeal carcinoma; polymorphism