title: Wnt3a: functions and implications in cancer.
abstract: Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.
authors.affiliation: Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. 514239052@qq.com.|Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. 514239052@qq.com.
authors.forename: Sha
authors.initials: S
authors.lastname: He
authors.affiliation: Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. luyi5555@hotmail.com.|Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. luyi5555@hotmail.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. realliuxia@sina.com.|Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. realliuxia@sina.com.
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.affiliation: Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. xin.huang2005@gmail.com.|Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. xin.huang2005@gmail.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. etkeller@umich.edu.
authors.forename: Evan T
authors.initials: ET
authors.lastname: Keller
authors.affiliation: Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, 51006, P.R. China. qianchn@sysucc.org.cn.
authors.forename: Chao-Nan
authors.initials: CN
authors.lastname: Qian
authors.affiliation: Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. jianzhang008@hotmail.com.|Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. jianzhang008@hotmail.com.|Department of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. jianzhang008@hotmail.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D002455:Cell Division / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014407:Tumor Cells, Cultured; D060449:Wnt Signaling Pathway / Q000502:physiology; D060509:Wnt3A Protein / Q000378:metabolism / Q000502:physiology*
chemical_list: D009363:Neoplasm Proteins; C555510:WNT3A protein, human; D060509:Wnt3A Protein