title: The multifaceted functions of sirtuins in cancer.
abstract: The sirtuins (SIRTs; of which there are seven in mammals) are NAD(+)-dependent enzymes that regulate a large number of cellular pathways and forestall the progression of ageing and age-associated diseases. In recent years, the role of sirtuins in cancer biology has become increasingly apparent, and growing evidence demonstrates that sirtuins regulate many processes that go awry in cancer cells, such as cellular metabolism, the regulation of chromatin structure and the maintenance of genomic stability. In this article, we review recent advances in our understanding of how sirtuins affect cancer metabolism, DNA repair and the tumour microenvironment and how activating or inhibiting sirtuins may be important in preventing or treating cancer.
authors.affiliation: Department of Biology, The Paul F. Glenn Center for the Science of Aging, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 68-280 Cambridge, Massachusetts 02139, USA.
authors.forename: Angeliki
authors.initials: A
authors.lastname: Chalkiadaki
authors.affiliation: Department of Biology, The Paul F. Glenn Center for the Science of Aging, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 68-280 Cambridge, Massachusetts 02139, USA.|Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Kendall Square, Cambridge, Massachusetts 02139, USA.
authors.forename: Leonard
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000818:Animals; D004260:DNA Repair / Q000502:physiology; D004273:DNA, Neoplasm / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000201:enzymology*; D037761:Sirtuins / Q000502:physiology*; D059016:Tumor Microenvironment / Q000502:physiology
chemical_list: D004273:DNA, Neoplasm; D037761:Sirtuins