title: A cluster of rapid disease progressors upon primary HIV-1 infection shared a novel variant with mutations in the p6gag/pol and pol/vif genes.
abstract: Few studies have described the etiologic factors associated with rapid AIDS onset during primary HIV-1 infection. Our molecular epidemiological study identified a cluster of individuals infected with HIV-1 variants characterized by novel mutations in the p6 and pol/vif genes during 2011 and 2013 in Osaka, Japan. Individuals positive for the novel HIV-1 variant showed rapid disease progression, suggesting a role of viral mutations in the fostering of the clinical course of HIV-1 infection.
authors.affiliation: aDepartment of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka bDepartment of Nephrology, Metabology and Immunology, Sakai City Hospital, Sakai cCenter for Infectious Diseases, Nara Medical University, Nara dDepartment of Clinical Laboratory, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan.
authors.forename: Haruyo
authors.initials: H
authors.lastname: Mori
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kojima
authors.forename: Takuya
authors.initials: T
authors.lastname: Kawahata
authors.forename: Motoo
authors.initials: M
authors.lastname: Matsuura
authors.forename: Kenji
authors.initials: K
authors.lastname: Uno
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Konishi
authors.forename: Jun
authors.initials: J
authors.lastname: Komano
mesh_terms: D000595:Amino Acid Sequence; D016000:Cluster Analysis; D015658:HIV Infections / Q000453:epidemiology / Q000473:pathology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007564:Japan / Q000453:epidemiology; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics*; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics*; D054320:vif Gene Products, Human Immunodeficiency Virus / Q000235:genetics*
chemical_list: D054301:gag Gene Products, Human Immunodeficiency Virus; C083002:p6 gag protein, Human immunodeficiency virus 1; D054302:pol Gene Products, Human Immunodeficiency Virus; D054320:vif Gene Products, Human Immunodeficiency Virus