title: Triple Quad-ICP-MS Measurement of Toxic Metals in Mainstream Cigarette Smoke from Spectrum Research Cigarettes.
abstract: We previously reported toxic metal concentrations in the mainstream smoke from 50 varieties of commercial cigarettes available in the USA using quadrupole inductively coupled plasma-mass spectrometry (ICP-MS). However, efforts to continue producing high quality data on select mainstream cigarette smoke constituents demand continued improvements in instrumentation and methodology and application of the methodology to cigarettes that differ in design or construction. Here we report a new application of 'triple quad'-ICP-MS instrumentation to analyze seven toxic metals in mainstream cigarette smoke from the Spectrum variable nicotine research cigarettes. The Spectrum cigarettes are available for research purposes in different configurations of low or conventional levels of nicotine, mentholated or nonmentholated, and tar delivery ranges described as 'low tar' or 'high tar'. Detailed characterizations of specific harmful or potentially harmful constituents delivered by these research cigarettes will help inform researchers using these cigarettes in exposure studies, cessation studies and studies related to nicotine addiction or compensation.
authors.affiliation: Division of Laboratory Sciences, Tobacco and Volatiles Branch, Centers for Disease Control & Prevention, National Center for Environmental Health, 4770 Buford Hwy NE Mail Stop F44, Atlanta, GA 30341-3717, USA rpappas@cdc.gov.
authors.forename: R Steven
authors.initials: RS
authors.lastname: Pappas
authors.affiliation: Division of Laboratory Sciences, Tobacco and Volatiles Branch, Centers for Disease Control & Prevention, National Center for Environmental Health, 4770 Buford Hwy NE Mail Stop F44, Atlanta, GA 30341-3717, USA.
authors.forename: Naudia
authors.initials: N
authors.lastname: Gray
authors.affiliation: Division of Laboratory Sciences, Tobacco and Volatiles Branch, Centers for Disease Control & Prevention, National Center for Environmental Health, 4770 Buford Hwy NE Mail Stop F44, Atlanta, GA 30341-3717, USA Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Gonzalez-Jimenez
authors.affiliation: Division of Laboratory Sciences, Tobacco and Volatiles Branch, Centers for Disease Control & Prevention, National Center for Environmental Health, 4770 Buford Hwy NE Mail Stop F44, Atlanta, GA 30341-3717, USA Battelle Analytical Services, Atlanta, GA, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Fresquez
authors.affiliation: Division of Laboratory Sciences, Tobacco and Volatiles Branch, Centers for Disease Control & Prevention, National Center for Environmental Health, 4770 Buford Hwy NE Mail Stop F44, Atlanta, GA 30341-3717, USA.
authors.forename: Clifford H
authors.initials: CH
authors.lastname: Watson
mesh_terms: D000075322:Heavy Metal Poisoning; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D019216:Metals, Heavy / Q000032:analysis; D009538:Nicotine / Q000032:analysis; D011041:Poisoning; D012906:Smoke / Q000032:analysis*; D062789:Tobacco Products / Q000032:analysis
chemical_list: D019216:Metals, Heavy; D012906:Smoke; D009538:Nicotine