title: Collagen Turnover in Wound Repair--A Macrophage Connection.
abstract: In this issue, Rohani et al. (2015) report on the role of macrophage-derived stromelysin-2 (matrix metalloproteinase (MMP)-10) in promoting the turnover of extracellular matrix (ECM) during cutaneous wound repair. They provide evidence that MMP-10 specifically enhances collagenolytic activity of murine MMP-13 produced by M2-like macrophages. These results emphasize the important role of macrophage-derived MMP-10 in regulating tissue remodeling and scar formation during wound healing.
authors.affiliation: Department of Dermatology, University of Turku, Turku, Finland; Department of Dermatology, Turku University Hospital, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland.
authors.forename: Liisa M
authors.initials: LM
authors.lastname: Nissinen
authors.affiliation: Department of Dermatology, University of Turku, Turku, Finland; Department of Dermatology, Turku University Hospital, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland. Electronic address: veli-matti.kahari@utu.fi.
authors.forename: Veli-Matti
authors.initials: VM
authors.lastname: Kähäri
mesh_terms: D000818:Animals; D017364:Collagenases / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D053506:Matrix Metalloproteinase 10 / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D014947:Wounds and Injuries / Q000201:enzymology*
chemical_list: D017364:Collagenases; D053506:Matrix Metalloproteinase 10