title: Effects of antidiabetes drugs on functional independence measure on a subacute rehabilitation ward for stroke patients.
abstract: It has been reported that the improvement of activities of daily living (ADL) by rehabilitation affects glycemic control. However, there are no reports about antidiabetes drugs as factors affecting the outcomes of rehabilitation. Therefore, we investigated the effects of antidiabetes drugs on functional independence measure (FIM) [total (T), motor (M), and cognition (C) items] in stroke patients with diabetes who were discharged from the subacute rehabilitation ward. We chose the frequently used antidiabetes drugs [sulfonylurea (SU), dipeptidyl peptidase-IV inhibitors (DPP-IVIs), and α-glycosidase inhibitors (α-GIs)] as the basis for categorizing the patients. We compared the patients' background features and laboratory data among the three groups. As a result, when SU was used in stroke patients with diabetes, it is difficult to obtain significant FIM-M gain, FIM-C gain, FIM-M efficiency, and FIM-C efficiency compared with of-GIs. As a reason for this, we hypothesize the possibility of the involvement of insulin resistance. Therefore, we consider that insulin resistance should be determined early and that it is important to reduce insulin resistance comprehensively by involving experts.
authors.forename: E
authors.initials: E
authors.lastname: Kose
authors.forename: M
authors.initials: M
authors.lastname: Toyoshima
authors.forename: T
authors.initials: T
authors.lastname: Tachi
authors.forename: H
authors.initials: H
authors.lastname: Teramachi
authors.forename: T
authors.initials: T
authors.lastname: Kawakubo
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003071:Cognition; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D057187:Independent Living; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D010351:Patient Discharge; D020521:Stroke / Q000150:complications / Q000523:psychology; D000071939:Stroke Rehabilitation
chemical_list: D007004:Hypoglycemic Agents