title: 450 IU versus 600 IU gonadotropin for controlled ovarian stimulation in poor responders: a randomized controlled trial.
abstract: OBJECTIVE
  To compare the outcomes of controlled ovarian stimulation/in vitro fertilization cycles using 450 IU and 600 IU gonadotropin per day in women at risk of poor ovarian response.
  
  
  METHODS
  Prospective randomized controlled nonblinded study.
  
  
  METHODS
  University-affiliated private IVF center.
  
  
  METHODS
  Women considered to be at risk of poor ovarian response: aged <41 years with basal FSH >10 IU/L, antimüllerian hormone <1 ng/mL, antral follicle count ≤ 8, or a previous IVF cycle with ≥ 300 IU/d gonadotropin that resulted in a cancellation, <8 follicles, or <5 oocytes.
  
  
  METHODS
  A total of 356 patients underwent a microdose GnRH agonist flare-up IVF/intracytoplasmic sperm injection protocol with a fixed daily dose of either 450 IU FSH (n = 176) or 600 IU FSH (n = 180) equally divided between Menopur and Bravelle.
  
  
  METHODS
  Number of mature oocytes retrieved.
  
  
  RESULTS
  The two groups were similar in terms of age, ovarian reserve, cause of infertility, duration of stimulation, and cycle cancellation rate. There were no significant differences in the number of metaphase II oocytes retrieved (4 [range 0-6] vs. 4 [range 2-7]), fertilization rate (62.4% vs. 57.0%), biochemical pregnancy rate (20.5% vs. 22.9%), clinical pregnancy rate (16.4% vs. 18.3%), and implantation rate (29.8% vs. 30.4%) between the 450 IU and 600 IU groups, respectively.
  
  
  CONCLUSIONS
  Gonadotropin of 600 IU/d does not improve outcome of IVF cycles compared with 450 IU/d in women at risk of poor ovarian response.
  
  
  BACKGROUND
  NCT00971152.
authors.affiliation: OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada. Electronic address: jessicalefebvre843@hotmail.com.
authors.forename: Jessica
authors.initials: J
authors.lastname: Lefebvre
authors.affiliation: OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Roland
authors.initials: R
authors.lastname: Antaki
authors.affiliation: OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Isaac-Jacques
authors.initials: IJ
authors.lastname: Kadoch
authors.affiliation: Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Nicola L
authors.initials: NL
authors.lastname: Dean
authors.affiliation: OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Camille
authors.initials: C
authors.lastname: Sylvestre
authors.affiliation: OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: François
authors.initials: F
authors.lastname: Bissonnette
authors.affiliation: OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Joanne
authors.initials: J
authors.lastname: Benoit
authors.affiliation: OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Ménard
authors.affiliation: OVO Clinic, Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada; Clinique de Procréation Assistée du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Louise
authors.initials: L
authors.lastname: Lapensée
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000009:adverse effects; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D008596:Menotropins / Q000008:administration & dosage* / Q000009:adverse effects; D054315:Oocyte Retrieval; D010053:Ovary / Q000187:drug effects* / Q000503:physiopathology; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D011792:Quebec; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome; D050477:Urofollitropin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D005300:Fertility Agents, Female; D050477:Urofollitropin; D008596:Menotropins; D005640:Follicle Stimulating Hormone
keywords: In vitro fertilization; controlled ovarian hyperstimulation; flare-up protocol; gonadotropin dose; poor ovarian responder