title: Deregulated Fcγ receptor expression in patients with CIDP.
abstract: OBJECTIVE
  To evaluate the expression of activating and inhibitory Fc-gamma receptors (FcγRs) before and during clinically effective therapy with IV immunoglobulin (IVIg) in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).
  
  
  METHODS
  Peripheral blood leukocyte subsets, including classical CD14(high)CD16(-) and nonclassical inflammatory CD14(low)CD16(+) monocytes as well as naive CD19(+)CD27(-) and memory CD19(+)CD27(+) B cells, were obtained at baseline and monitored at 2 and 4-8 weeks after initiation of IVIg therapy.
  
  
  RESULTS
  Compared with healthy donors matched by age and sex, patients with CIDP showed increased expression levels of the activating high-affinity FcγR1 on CD14(high)CD16(-) (p < 0.001) and CD14(low)CD16(+) monocytes (p < 0.001). Expression of the activating low-affinity FcγRIIA was increased on CD14(low)CD16(+) monocytes (p = 0.023). Conversely, expression of the inhibitory FcγRIIB was reduced on naive (p = 0.009) and memory (p = 0.002) B cells as well as on CD14(high)CD16(-) monocytes (p = 0.046). Clinically effective IVIg therapy partially restored deregulated FcγR expression on B cell subsets and monocytes.
  
  
  CONCLUSIONS
  The FcγR regulatory system is disturbed in patients with CIDP. Balancing activating vs inhibitory FcγR expression might provide a clinical benefit for patients with CIDP.
authors.affiliation: Institute of Experimental Immunology (I.Q., F.C., J.D.L.), Department of Neuroinflammation, University of Zürich, Switzerland; Department of Biology (F.N.), Institute of Genetics, University of Erlangen-Nürnberg, Erlangen, Germany; Department of Neurology (B.T.), University Hospital Marburg, Marburg, Germany; and Department of Neurology (J.D.L.), University Hospital Basel, Basel, Switzerland.
authors.forename: Isaak
authors.initials: I
authors.lastname: Quast
authors.affiliation: Institute of Experimental Immunology (I.Q., F.C., J.D.L.), Department of Neuroinflammation, University of Zürich, Switzerland; Department of Biology (F.N.), Institute of Genetics, University of Erlangen-Nürnberg, Erlangen, Germany; Department of Neurology (B.T.), University Hospital Marburg, Marburg, Germany; and Department of Neurology (J.D.L.), University Hospital Basel, Basel, Switzerland.
authors.forename: Flavio
authors.initials: F
authors.lastname: Cueni
authors.affiliation: Institute of Experimental Immunology (I.Q., F.C., J.D.L.), Department of Neuroinflammation, University of Zürich, Switzerland; Department of Biology (F.N.), Institute of Genetics, University of Erlangen-Nürnberg, Erlangen, Germany; Department of Neurology (B.T.), University Hospital Marburg, Marburg, Germany; and Department of Neurology (J.D.L.), University Hospital Basel, Basel, Switzerland.
authors.forename: Falk
authors.initials: F
authors.lastname: Nimmerjahn
authors.affiliation: Institute of Experimental Immunology (I.Q., F.C., J.D.L.), Department of Neuroinflammation, University of Zürich, Switzerland; Department of Biology (F.N.), Institute of Genetics, University of Erlangen-Nürnberg, Erlangen, Germany; Department of Neurology (B.T.), University Hospital Marburg, Marburg, Germany; and Department of Neurology (J.D.L.), University Hospital Basel, Basel, Switzerland.
authors.forename: Björn
authors.initials: B
authors.lastname: Tackenberg
authors.affiliation: Institute of Experimental Immunology (I.Q., F.C., J.D.L.), Department of Neuroinflammation, University of Zürich, Switzerland; Department of Biology (F.N.), Institute of Genetics, University of Erlangen-Nürnberg, Erlangen, Germany; Department of Neurology (B.T.), University Hospital Marburg, Marburg, Germany; and Department of Neurology (J.D.L.), University Hospital Basel, Basel, Switzerland.
authors.forename: Jan D
authors.initials: JD
authors.lastname: Lünemann