title: Corneal melanosis successfully treated using topical mitomycin-C and alcohol corneal epitheliectomy: a 3-year follow-up case report.
abstract: We report a case of primary acquired corneal melanosis without atypia associated with corneal haze in a patient with a history of limbal malignant melanoma and the effect of mitomycin-C. A 75-year-old woman with a history of limbal malignant melanoma presented with loss of vision in right eye. Corneal examination showed a patchy melanotic pigmentation with a central haze. Topical mitomycin-C improved visual acuity and corneal haze. However, the pigmented lesions persisted, and they were removed with alcohol corneal epitheliectomy. Histopathological examination demonstrated primary acquired melanosis without atypia. The lesions were successfully removed, and there were no recurrences during the follow-up period of 36 months. The association of conjunctival and corneal melanosis without atypia is a rare condition. In addition, co-existence of central corneal haze and melanosis may decrease visual acuity. Topical mitomycin-C and alcohol corneal epitheliectomy can be useful treatments in this condition.
authors.affiliation: Department of Ophthalmology, Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, TR.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Balcı
authors.affiliation: Department of Ophthalmology, Medical School, Pamukkale University, Denizli, TR.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yağcı
authors.affiliation: Eye Clinic, Erciş State Hospital, Van, TR.
authors.forename: Emre
authors.initials: E
authors.lastname: Güler
authors.affiliation: Department of Pathology, Medical School, Fatih University, Istanbul, TR.
authors.forename: Hacer
authors.initials: H
authors.lastname: Haltaş
authors.affiliation: Department of Ophthalmology, Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, TR.
authors.forename: Rahmi
authors.initials: R
authors.lastname: Duman
authors.affiliation: Department of Ophthalmology, Medical School, Gazi University, Ankara, TR.
authors.forename: İbrahim F
authors.initials: İF
authors.lastname: Hepşen
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003230:Conjunctival Neoplasms / Q000150:complications; D003316:Corneal Diseases / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008545:Melanoma / Q000150:complications; D008548:Melanosis / Q000188:drug therapy* / Q000209:etiology; D016685:Mitomycin / Q000627:therapeutic use*; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin