title: Sexual dysfunction in multiple sclerosis: A 6-year follow-up study.
abstract: Sexual dysfunction (SD) is a common but often overlooked and undertreated symptom in multiple sclerosis (MS). The purpose of our longitudinal study was to explore the changes in the level of sexual functioning in MS cohort after a period of 3 and 6 years of follow-up, as well as to investigate the predictors of changes in SD during the period of observation.
  
  
  
  The study population comprise a cohort of 93 patients with MS (McDonald's criteria, 2001) who were assessed at three time points during the study (baseline, and at the 3- and 6-year follow-up). The presence and severity of SD was quantified by Szasz sexual functioning scale. Independent predictors of the ordinal-scaled measure of sexual problems were identified using a generalized linear mixed regression models.
  
  
  
  The number of reported SD symptoms increased markedly for both genders during the whole period of observation. Duration of follow-up, age, level of physical disability, depression and fatigue were identified as independent prognostic factors for deterioration of sexual functioning in patients with MS during the 6-year follow-up.
  
  
  
  Our study provides insight into dynamics of change in sexual function among patients with MS and predictors of change, over the period of 6 years.
authors.affiliation: Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
authors.forename: Darija
authors.initials: D
authors.lastname: Kisic-Tepavcevic
authors.affiliation: Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Pekmezovic
authors.affiliation: Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
authors.forename: Goran
authors.initials: G
authors.lastname: Trajkovic
authors.affiliation: Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Stojsavljevic
authors.affiliation: Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
authors.forename: Irena
authors.initials: I
authors.lastname: Dujmovic
authors.affiliation: Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia.
authors.forename: Sarlota
authors.initials: S
authors.lastname: Mesaros
authors.affiliation: Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia. Electronic address: jelena60@eunet.rs.
authors.forename: Jelena
authors.initials: J
authors.lastname: Drulovic
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D012720:Severity of Illness Index; D012735:Sexual Dysfunction, Physiological / Q000209:etiology / Q000503:physiopathology*
keywords: Cohort study; Gender; Libido; Multiple sclerosis; Predictors; Sexual dysfunction