title: Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management.
abstract: Recent advances in the development of electronic technologies and biomedical devices offer opportunities for non-invasive, quantitative assessment of cutaneous wound healing on the skin. Existing methods, however, still rely on visual inspections through various microscopic tools and devices that normally include high-cost, sophisticated systems and require well trained personnel for operation and data analysis. Here, we describe methods and protocols to fabricate a conformal, skin-like electronics system that enables conformal lamination to the skin surface near the wound tissues, which provides recording of high fidelity electrical signals such as skin temperature and thermal conductivity. The methods of device fabrication provide details of step-by-step preparation of the microelectronic system that is completely enclosed with elastomeric silicone materials to offer electrical isolation. The experimental study presents multifunctional, biocompatible, waterproof, reusable, and flexible/stretchable characteristics of the device for clinical applications. Protocols of clinical testing provide an overview and sequential process of cleaning, testing setup, system operation, and data acquisition with the skin-like electronics, gently mounted on hypersensitive, cutaneous wound and contralateral tissues on patients.
authors.affiliation: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University.
authors.forename: Woosik
authors.initials: W
authors.lastname: Lee
authors.affiliation: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University.
authors.forename: Ohjin
authors.initials: O
authors.lastname: Kwon
authors.affiliation: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University.
authors.forename: Dong Sup
authors.initials: DS
authors.lastname: Lee
authors.affiliation: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University; Center for Rehabilitation Science and Engineering, Virginia Commonwealth University; Massey Cancer Center, Virginia Commonwealth University; whyeo@vcu.edu.
authors.forename: Woon-Hong
authors.initials: WH
authors.lastname: Yeo
mesh_terms: D004581:Electronics / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D055616:Microtechnology / Q000379:methods; D012867:Skin / Q000293:injuries*; D012881:Skin Temperature; D013814:Thermal Conductivity; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000503:physiopathology / Q000628:therapy*