title: Comparison of Perioperative Morbidity of Radical Cystectomy With Neobladder Versus Ileal Conduit: A Matched Pair Analysis of 170 Patients.
abstract: BACKGROUND
  The objective of this study was to evaluate if use of an ileal conduit (IC) versus a neobladder (NB) during radical cystectomy (RC) can play a role in the morbidity of the surgical procedure.
  
  
  METHODS
  Since 2001 our institution has prospectively maintained a database of more than 500 patients who have undergone RC. The records of 258 patients who received an RC and IC and 121 who received an RC and NB were reviewed for the present study. Using a binary logistic regression model a propensity score was generated for the following factors: sex, age, smoking habit, Charlson score, American Society of Anesthesiology score, preoperative hydronephrosis, and pathologic T stage. Two groups of patients with similar propensity scores were created with a ratio of 1:1, one group who received an IC and another who received an NB. The following features were compared between the 2 groups: blood loss, intraoperative complication rate, time to oral intake resumption, postoperative complication rate (overall, Clavien classification 1-2, Clavien classification 3-5, related to RC, related to urinary reconstruction).
  
  
  RESULTS
  In total, 170 patients were selected; 85 with NB, 85 with IC, and the 2 groups were well matched according to the desired features. No differences were noted for all of the compared features.
  
  
  CONCLUSIONS
  The morbidity of RC does not seem to be affected by the choice of IC versus NB.
authors.affiliation: Division of Urology, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Antonelli
authors.affiliation: Division of Urology, Spedali Civili Hospital, University of Brescia, Brescia, Italy. Electronic address: belot.sandra@gmail.com.
authors.forename: Sandra
authors.initials: S
authors.lastname: Belotti
authors.affiliation: Division of Urology, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Cristinelli
authors.affiliation: Division of Urology, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Luca
authors.affiliation: Division of Urology, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Simeone
mesh_terms: D000368:Aged; D015653:Cystectomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D011183:Postoperative Complications; D057216:Propensity Score; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000601:surgery*; D014547:Urinary Diversion / Q000009:adverse effects*
keywords: Clavien classification; Complication; Paduan ileal NB; Propensity score; Urinary diversion