title: Efficacy and Safety of Mechanical Thrombectomy in Treating Acute Ischemic Stroke: A Meta Analysis.
abstract: OBJECTIVE
  Mechanical thrombectomy (MT) is a promising treatment for acute ischemic stroke (AIS). But the results of completed trials were contradictory. Hence, we performed a meta-analysis to evaluate the efficacy and safety of MT in treating AIS.
  
  
  METHODS
  Literatures were searched in the databases including Pubmed, Cochrane Library, Web of Science and Ovid-SP. The bias and quality of publications with randomized controlled trials (RCTs) were assessed with the Cochrane collaboration's tool for assessing risk of bias.
  
  
  RESULTS
  Totally 16 publications matched the inclusion criteria, including seven independent RCTs and 2043 AIS patients. The results showed that the recanalization rate and the modified Rankin score of 0-2 at 90 days after treatment were better in MT combining standard care group, but the mortality had no significant difference, even the incidence of intracerebral hemorrhage during follow-up period was worse, as compared with standard care group.
  
  
  CONCLUSIONS
  MT combining standard care would be an effective and promising treatment for AIS patients according to the present study.
authors.affiliation: b Xindu Hospital of Traditional Chinese Medicine , Chengdu , Sichuan Province , China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Neurology, West China Hospital , Sichuan University , Chengdu , Sichuan Province , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a Department of Neurology, West China Hospital , Sichuan University , Chengdu , Sichuan Province , China.
authors.forename: Peiwei
authors.initials: P
authors.lastname: Hong
mesh_terms: D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D061185:Mechanical Thrombolysis / Q000009:adverse effects / Q000401:mortality; D017594:Publication Bias; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000188:drug therapy / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: IV rtPA; acute ischemic stroke; endovascular treatment; mechanical thrombectomy; meta analysis; thrombolysis