title: The Efficacy of Medical Expulsive Therapy (MET) in Improving Stone-free Rate and Stone Expulsion Time, After Extracorporeal Shock Wave Lithotripsy (SWL) for Upper Urinary Stones: A Systematic Review and Meta-analysis.
abstract: In this meta-analysis, we included randomized studies on medical expulsive therapy implemented following shock wave lithotripsy for renal and ureteral stones. Pooled results demonstrated the efficacy of α-blockers, nifedipine, Rowatinex, and Uriston in increasing stone clearance. In addition, the time to stone elimination, the intensity of pain, the formation of steinstrasse, and the need for auxiliary procedures were reduced mainly with α-blockers. Expulsion rate was not correlated with the type of α-blocker, the diameter, and the location of stone. Our results show that medical expulsive therapy for residual fragments after shock wave lithotripsy should be implemented in clinical practice.
authors.affiliation: Second Department of Urology, Athens Medical School, Sismanogleio General Hospital, Athens, Greece.
authors.forename: Andreas
authors.initials: A
authors.lastname: Skolarikos
authors.affiliation: Department of Urology, G. Hatzikosta General Hospital, Ioannina, Greece. Electronic address: nikolaosgrivas@hotmail.com.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Grivas
authors.affiliation: Department of Urology, University of Patras, Patras, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kallidonis
authors.affiliation: Second Department of Urology, Athens Medical School, Sismanogleio General Hospital, Athens, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Mourmouris
authors.affiliation: Department of Urology, Ippokrateio General Hospital, Thessaloniki, Greece.
authors.forename: Thomas
authors.initials: T
authors.lastname: Rountos
authors.affiliation: Second Department of Urology, Athens Medical School, Sismanogleio General Hospital, Athens, Greece.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Fiamegos
authors.affiliation: Department of Urology, University of Ioannina, Ioannina, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Stavrou
authors.affiliation: First Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Chris
authors.initials: C
authors.lastname: Venetis
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D006801:Humans; D007669:Kidney Calculi / Q000628:therapy*; D008096:Lithotripsy; D009543:Nifedipine / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use; D013729:Terpenes / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D014514:Ureteral Calculi / Q000628:therapy*
chemical_list: D000317:Adrenergic alpha-Antagonists; D002121:Calcium Channel Blockers; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D013729:Terpenes; C041804:choreito; C000607376:uriston; C036965:Rowatinex; D009543:Nifedipine