title: Orthostatic hypotension is associated with decreased cerebrospinal fluid levels of chromogranin A in early stage of Parkinson disease.
abstract: An association between the CSF chromogranin A (CgA) and orthostatic blood pressure changes was investigated in 20 patients in the early stage of Parkinson disease (PD). There was a positive correlation between the CSF CgA and diastolic blood pressure change, when CSF CgA levels were lower in patients with orthostatic hypotension (OH). Decreased CSF CgA may be useful in predicting OH in the early stage of PD.
authors.affiliation: Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, I.P. Pavlova 6, 77520, Olomouc, Czech Republic. michaela.kaiserova@email.cz.
authors.forename: Michaela
authors.initials: M
authors.lastname: Kaiserova
authors.affiliation: Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, I.P. Pavlova 6, 77520, Olomouc, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Prikrylova Vranova
authors.affiliation: Department of Internal Medicine I-Cardiology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Galuszka
authors.affiliation: Department of Laboratory Medicine, Central Moravian Hospital County Inc., Prostejov, Czech Republic.|Department of Medicine, Central Moravian Hospital County Inc., Prostejov, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Stejskal
authors.affiliation: Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, I.P. Pavlova 6, 77520, Olomouc, Czech Republic.
authors.forename: Katerina
authors.initials: K
authors.lastname: Mensikova
authors.affiliation: Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Zapletalova
authors.affiliation: Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, I.P. Pavlova 6, 77520, Olomouc, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Mares
authors.affiliation: Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, I.P. Pavlova 6, 77520, Olomouc, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Kanovsky
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D053379:Chromogranin A / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000453:epidemiology; D018667:Tilt-Table Test / Q000379:methods
chemical_list: D015415:Biomarkers; D053379:Chromogranin A
keywords: Cerebrospinal fluid; Chromogranin A; Orthostatic hypotension; Parkinson’s disease