title: γ- and β-Peptide Foldamers from Common Multifaceted Building Blocks: Synthesis and Structural Characterization.
abstract: Structural characterization of 3,4-disubstituted γ-peptide and 2,3-disubstituted β-peptide foldamers derived from common multifaceted β-nitromethyl γ-amino acids and the chemical transformation of the β-nitromethyl group in γ-peptides into various functional derivatives are reported. The γ(3,4)-oligomers and α,γ-hybrid peptides showed characteristic C14-and C12-helical conformations in single crystals. Further, the new 2,3-disubstituted acyclic β-peptide showed the C6-helical conformation despite the poor geometry of H-bonds.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: Mothukuri
authors.initials: M
authors.lastname: Ganesh Kumar
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: Hosahudya N
authors.initials: HN
authors.lastname: Gopi
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D017433:Protein Structure, Secondary
chemical_list: D000596:Amino Acids; D010455:Peptides