title: Optimization of dose of collagen hydrolysate to prevent UVB-irradiated skin damage.
abstract: Collagen hydrolysate (CH) was orally administered to UVB-irradiated hairless mice at doses of 20, 200-2000 mg/kg BW/day. The low dose of CH increased the skin hydration and reduced the transepidermal water loss on damaged skin. These results suggested the optimal dose of collagen to improve the UV-damaged skin condition.
authors.affiliation: a Laboratory of Applied Protein Chemistry, Faculty of Agriculture , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Jimbo
authors.affiliation: a Laboratory of Applied Protein Chemistry, Faculty of Agriculture , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors.forename: Chinatsu
authors.initials: C
authors.lastname: Kawada
authors.affiliation: a Laboratory of Applied Protein Chemistry, Faculty of Agriculture , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nomura
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003094:Collagen / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D006868:Hydrolysis; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D010446:Peptide Fragments / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects; D014867:Water / Q000378:metabolism; D014870:Water Loss, Insensible / Q000187:drug effects* / Q000528:radiation effects
chemical_list: D010446:Peptide Fragments; D014867:Water; D003094:Collagen
keywords: TEWL (Transepidermal water loss); collagen hydrolysate; hyaluronic acid; skin hydration