title: Rare presentation of orbital plasmablastic lymphoma with oral cavity involvement in an HIV-negative patient.
abstract: Plasmablastic lymphoma is described as a subtype of non-Hodgkin's lymphoma under the category of diffuse large B-cell lymphoma. It is classified by WHO as HIV-associated lymphoma of the oral cavity. Several cases have been reported in non-HIV patients with extra-oral involvement. The characteristic immunohistochemical markers are generally positive for CD138, CD38 and MUM1/IRF4, and negative or weakly positive for pan B-cell markersCD20, CD79a, PAX-5 and BCL-6. We report a rare case of orbital plasmablastic lymphoma with oral and oropharyngeal involvement where the immunohistochemical markers were positive for CD138, CD43, CD45, CD79a and MUM1. A small subset of markers was weakly positive for CD20, CD30 and κ, and negative for CD10, BCL-6, CD4, CD56 and Epstein-Barr virus-encoded small RNA (EBER). Our case reinforces the fact that plasmablastic lymphoma is a different entity of non-Hodgkin's lymphoma that cannot simply be classified under diffuse large B-cell lymphoma. It demands modification of the WHO classification.
authors.affiliation: Department of Internal Medicine, Jamaica Hospital Medical Center, Jamaica, New York, USA.
authors.forename: Sidhertha
authors.initials: S
authors.lastname: Podder
authors.affiliation: Department of Public Health, Icahn School of Medicine at Mount Sinai, NewYork, New York, USA.
authors.forename: Prerna
authors.initials: P
authors.lastname: Khetan
authors.affiliation: Department of Hematology/Oncology Unit, Jamaica Hospital Medical Centre, Jamaica, New York, USA.
authors.forename: Shetra
authors.initials: S
authors.lastname: Sivamurthy
authors.affiliation: Jamaica Hospital Medical Centre, Jamaica, New York, USA.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Mandal
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003680:Deglutition Disorders / Q000209:etiology; D018023:HIV Seronegativity; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009062:Mouth Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D009549:Nigeria; D009918:Orbital Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D000069293:Plasmablastic Lymphoma / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor