title: Pharmacological cognitive enhancement: treatment of neuropsychiatric disorders and lifestyle use by healthy people.
abstract: Neuropsychiatric disorders typically manifest as problems with attentional biases, aberrant learning, dysfunctional reward systems, and an absence of top-down cognitive control by the prefrontal cortex. In view of the cost of common mental health disorders, in terms of distress to the individual and family in addition to the financial cost to society and governments, new developments for treatments that address cognitive dysfunction should be a priority so that all members of society can flourish. Cognitive enhancing drugs, such as cholinesterase inhibitors and methylphenidate, are used as treatments for the cognitive symptoms of Alzheimer's disease and attention deficit hyperactivity disorder. However, these drugs and others, including modafinil, are being increasingly used by healthy people for enhancement purposes. Importantly for ethical and safety reasons, the drivers for this increasing lifestyle use of so-called smart drugs by healthy people should be considered and discussions must occur about how to ensure present and future pharmacological cognitive enhancers are used for the benefit of society.
authors.affiliation: Department of Psychiatry, Cambridge, UK. Electronic address: bjs1001@medschl.cam.ac.uk.
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Sahakian
authors.affiliation: Medical Research Council-Wellcome Trust Behavioural and Clinical Neuroscience Institute, Addenbrooke's Hospital, Cambridge, UK; Department of Psychology, University of Cambridge, Cambridge, UK.
authors.forename: Sharon
authors.initials: S
authors.lastname: Morein-Zamir
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D001289:Attention Deficit Disorder with Hyperactivity; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy*; D006801:Humans; D008019:Life Style; D008774:Methylphenidate / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000077408:Modafinil; D018697:Nootropic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001559:Benzhydryl Compounds; D002800:Cholinesterase Inhibitors; D018697:Nootropic Agents; D008774:Methylphenidate; D000077408:Modafinil