title: Differentiation and function of group 3 innate lymphoid cells, from embryo to adult.
abstract: Group 3 innate lymphoid cells (ILC3) represent a heterogeneous population of cells that share the nuclear hormone receptor RORγt (retinoic acid receptor-related orphan receptor γt) as a master regulator for differentiation and function. ILC3 can be divided into two major subsets based on the cell surface expression of the natural cytotoxicity receptor (NCR), NKp46. A subset of NCR(-) ILC3 includes the previously known lymphoid-tissue inducer cells that are essential for the embryonic formation of peripheral lymph nodes and Peyer's patches. After birth, the NCR(-) and NCR(+) ILC3 contribute to the maintenance of health but also to inflammation in mucosal tissues. This review will describe the differentiation pathways of ILC3, their involvement in the development of the adaptive immune system and their role in the establishment and maintenance of gut immunity.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm U1104, CNRS UMR7280, 13288 Marseille, France vandepavert@ciml.univ-mrs.fr.
authors.forename: Serge A
authors.initials: SA
authors.lastname: van de Pavert
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm U1104, CNRS UMR7280, 13288 Marseille, France Immunologie, Hôpital de la Conception, Assistance Publique - Hôpitaux de Marseille, 13385 Marseille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
mesh_terms: D000328:Adult; D000818:Animals; D002454:Cell Differentiation; D004622:Embryo, Mammalian; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology*; D008198:Lymph Nodes / Q000196:embryology / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D055627:Natural Cytotoxicity Triggering Receptor 1 / Q000378:metabolism; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000378:metabolism*; D010581:Peyer's Patches / Q000196:embryology / Q000276:immunology*
chemical_list: C112260:NCR1 protein, human; D055627:Natural Cytotoxicity Triggering Receptor 1; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3
keywords: NKp46; Ncr; RORγt; gut immunity; lymph node development