title: Using human genetics to make new medicines.
abstract: Jeffrey Barrett, Ian Dunham and Ewan Birney discuss the initiatives of the newly founded Centre for Therapeutic Target Validation, including a range of approaches to use human genetics to inform drug discovery and make better medicines.
authors.affiliation: Centre for Therapeutic Target Validation.|Wellcome Trust Sanger Institute.|European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Barrett
authors.affiliation: Centre for Therapeutic Target Validation.|Wellcome Trust Sanger Institute.|European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Dunham
authors.affiliation: European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Ewan
authors.initials: E
authors.lastname: Birney
mesh_terms: D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D003424:Crohn Disease / Q000235:genetics; D055808:Drug Discovery / Q000379:methods*; D014644:Genetic Variation; D005826:Genetics, Medical / Q000379:methods*; D055106:Genome-Wide Association Study; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics; D007391:International Cooperation; D051906:Smad7 Protein / Q000235:genetics
chemical_list: C497806:SMAD7 protein, human; D051906:Smad7 Protein; C553220:HMGCR protein, human; D006903:Hydroxymethylglutaryl CoA Reductases