title: Irreversible Electroporation of Hepatic and Pancreatic Malignancies: Radiologic-Pathologic Correlation.
abstract: Irreversible electroporation (IRE) is a novel therapy that has shown to be a feasible and promising alternative to conventional ablative techniques when treating tumors near vital structures or blood vessels. The clinical efficacy of IRE has been evaluated using established imaging criteria. This study evaluates the histologic and imaging response of hepatic and pancreatic malignancies that were surgically resected after IRE. In total, 12 lesions ablated with IRE were included, including 3 pancreatic carcinomas, 5 primary tumors of the liver, and 4 metastatic tumors of the liver. The rate of complete response to IRE was 25% based on the histologic evaluation of the resected tumors. Although treatment-related vessel wall changes were noted in several cases in histologic findings, there was no evidence of vascular luminal narrowing or obliteration in any of the specimens. The imaging response to IRE before surgical resection usually resulted in underestimation of disease burden when compared with the histologic response seen on the resected specimens.
authors.affiliation: Interventional Radiology, Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL. Electronic address: a.gonzalez-beicos@med.miami.edu.
authors.forename: Aldo
authors.initials: A
authors.lastname: Gonzalez-Beicos
authors.affiliation: Interventional Radiology, Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL.
authors.forename: Shree
authors.initials: S
authors.lastname: Venkat
authors.affiliation: Interventional Radiology, Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL.
authors.forename: Tanakorn
authors.initials: T
authors.lastname: Songrug
authors.affiliation: Gastrointestinal Pathology, Department of Pathology, University of Miami, Miller School of Medicine, Miami, FL.
authors.forename: Julio
authors.initials: J
authors.lastname: Poveda
authors.affiliation: Gastrointestinal Pathology, Department of Pathology, University of Miami, Miller School of Medicine, Miami, FL.
authors.forename: Monica
authors.initials: M
authors.lastname: Garcia-Buitrago
authors.affiliation: Interventional Radiology, Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL.
authors.forename: Prasoon
authors.initials: P
authors.lastname: Poozhikunnath Mohan
authors.affiliation: Interventional Radiology, Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL.
authors.forename: Govindarajan
authors.initials: G
authors.lastname: Narayanan
mesh_terms: D055011:Ablation Techniques / Q000009:adverse effects / Q000295:instrumentation; D000368:Aged; D001706:Biopsy; D016923:Cell Death; D016208:Databases, Factual; D018274:Electroporation / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D049268:Positron-Emission Tomography; D011183:Postoperative Complications / Q000209:etiology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D025321:Surgery, Computer-Assisted / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: hepatic malignancy; irreversible electroporation; pancreatic malignancy