title: Association of the recurrence of vocal leukoplakia with MDM2-309 variants over a 2-year period: a prospective study.
abstract: CONCLUSIONS
  MDM2-309 polymorphism variant genotypes decrease the risk of recurrence in vocal leukoplakia.
  
  
  OBJECTIVE
  The results of a previous study 2 years ago showed the effect of mouse double minute 2 homolog (MDM2) SNP309 polymorphisms in people with laryngeal carcinoma and vocal leukoplakia (a pre-cancerous laryngeal carcinoma lesion). This prospective, clinical trial was performed to assess the relationship between MDM2-309 polymorphism variants and recurrence/cancerization rates in people with vocal leukoplakia over a 2-year period.
  
  
  METHODS
  A total of 61 post-operative patients with vocal leukoplakia participated in this prospective, observational, 2-year, follow-up study, and were genotyped for the MDM2-309 gene using pyrosequencing. Recurrence and cancerization rates were used to assess the relationship between the clinical outcome and the genotype variants.
  
  
  RESULTS
  The recurrence rate in the GT genotypes group was lower than that in the normal TT genotype group (17.2% vs 50%, p = 0.05) and there was a significantly lower recurrence rate in the GG genotype group than in the normal TT genotype group (10% vs 50%, p = 0.03). However, there was no statistically significant difference in the cancerization rate between the MDM2-309 variant (GT + GG) genotypes group and the normal TT genotype group (12.2% vs 8.3%, p > 0.05) over the 2-year follow-up period.
authors.affiliation: a Department of Otolaryngology , Eye Ear Nose & Throat Hospital, Fudan University , Shanghai , PR China .
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.affiliation: a Department of Otolaryngology , Eye Ear Nose & Throat Hospital, Fudan University , Shanghai , PR China .
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.affiliation: a Department of Otolaryngology , Eye Ear Nose & Throat Hospital, Fudan University , Shanghai , PR China .
authors.forename: Duo
authors.initials: D
authors.lastname: Zhang
authors.affiliation: a Department of Otolaryngology , Eye Ear Nose & Throat Hospital, Fudan University , Shanghai , PR China .
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.affiliation: b Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine , Shanghai , PR China and.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.affiliation: a Department of Otolaryngology , Eye Ear Nose & Throat Hospital, Fudan University , Shanghai , PR China .|c Department of Otolaryngology, Pudong Hospital , Fudan University , Shanghai , PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tao
authors.affiliation: b Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine , Shanghai , PR China and.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Lu
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D007971:Leukoplakia / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D013997:Time Factors
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
keywords: Cancerization; MDM2; genotype variants; laryngeal carcinoma; recurrence; vocal leukoplakia