title: Metabolomics in bladder cancer: a systematic review.
abstract: Bladder cancer (BC) is the most common urological malignancy. Early diagnosis of BC is crucial to improve patient outcomes. Currently, metabolomics is a potential technique that can be used to detect BC. We reviewed current publications and synthesised the findings on BC and metabolomics, i.e. metabolite upregulation and downregulation. Fourteen metabolites (lactic acid, leucine, valine, phenylalanine, glutamate, histidine, aspartic acid, tyrosine, serine, uracil, hypoxanthine, carnitine, pyruvic acid and citric acid) were identified as potential biomarkers for BC. In conclusion, this systematic review presents new opportunities for the diagnosis of BC.
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Yidong
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Xiaheng
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Pengchao
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tao
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Qin
authors.affiliation: Research Division of Clinical Pharmacology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Jifu
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lu
keywords: Bladder cancer; mass spectrometry; metabolomics; systematic review