title: SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer.
abstract: In this issue, An et al. (2015) and Gan et al. (2015) reveal that the CRL3(SPOP) ubiquitin ligase mediates the degradation of the transcription factor ERG and that translocations of ERG or mutations in SPOP prevent CRL3(SPOP)-dependent degradation of ERG in prostate cancer cells.
authors.affiliation: Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Perlmutter NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, 522 First Avenue, SRB 1107, New York, NY 10016, USA. Electronic address: shanshan.duan@nyumc.org.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Duan
authors.affiliation: Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Perlmutter NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, 522 First Avenue, SRB 1107, New York, NY 10016, USA. Electronic address: michele.pagano@nyumc.org.
authors.forename: Michele
authors.initials: M
authors.lastname: Pagano
mesh_terms: D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000502:physiology*; D015514:Oncogene Proteins, Fusion / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D012097:Repressor Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*
chemical_list: D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D012097:Repressor Proteins; D015534:Trans-Activators; D046988:Proteasome Endopeptidase Complex