title: [Possibilities of pharmacotherapy for chronic venous insufficiency with diosmin preparations from the position of the endothelial functional state].
abstract: Despite a high level of the development of modern angiology and vascular surgery, the problem of chronic venous insufficiency (CVI) complicating the course of various venous diseases seems to have no tendency towards being solved, thus calling forth permanent search for optimization of methods of treatment and rehabilitation of patients presenting with the above-mentioned syndrome. The article presents a review of contemporary studies dedicated to the problem of correcting CVI. Special attention is paid to the endothelial state in CVI and possibilities of correcting endothelial dysfunction with the use of bioflavonoids, in particular, diosmin. Also presented herein are the results of an original experimental study dedicated to peculiarities of the endothelial functional state, endothelial dysfunction, and correction thereof on the background of the existing CVI.
authors.affiliation: Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia.
authors.forename: R E
authors.initials: RE
authors.lastname: Kalinin
authors.affiliation: Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Suchkov
authors.affiliation: Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Pshennikov
authors.affiliation: Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia.
authors.forename: N D
authors.initials: ND
authors.lastname: Mzhavanadze
mesh_terms: D002317:Cardiovascular Agents / Q000378:metabolism / Q000494:pharmacology; D002908:Chronic Disease; D004145:Diosmin / Q000378:metabolism / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000150:complications*; D014689:Venous Insufficiency / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology
chemical_list: D002317:Cardiovascular Agents; D004145:Diosmin