title: The Oncologic Safety of Breast Fat Grafting and Contradictions Between Basic Science and Clinical Studies: A Systematic Review of the Recent Literature.
abstract: Fat grafting is increasingly popular and is becoming a common practice in plastic surgery for postmastectomy breast reconstruction and aesthetic breast augmentation; however, concerns over the oncologic safety remains a controversial and hot topic among scientists and surgeons. Basic science and laboratory research repeatedly show a potentially dangerous effect of adipose-derived stem cells on breast cancer cells; however, clinical research, although limited, continually fails to show an increase in breast cancer recurrence after breast fat grafting, with the exception of 1 small study on a subset patient population with intraepithelial neoplasm of the breast. The aim of this review is to summarize the recent conflicting basic science and clinical data to better understand the safety of breast fat grafting from an oncological perspective.
authors.affiliation: From the *Department of Surgery, and †Division of Plastic Surgery, Department of Surgery, University of California Davis Medical Center, Sacramento, CA.
authors.forename: Heath J
authors.initials: HJ
authors.lastname: Charvet
authors.forename: Hakan
authors.initials: H
authors.lastname: Orbay
authors.forename: Michael S
authors.initials: MS
authors.lastname: Wong
authors.forename: David E
authors.initials: DE
authors.lastname: Sahar
mesh_terms: D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000009:adverse effects* / Q000379:methods; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects*; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D050151:Subcutaneous Fat / Q000637:transplantation*; D014182:Transplantation, Autologous / Q000009:adverse effects