title: Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis.
abstract: About 20% of the world's population uses some form of betel nut, which suggests that the incidence of oral submucous fibrosis (OSF) is higher than current estimates. OSF has the potential to undergo malignant transformation; thus, there is a need to identify relevant markers to assess its aggressiveness. We evaluated changes in COX-2, p53, and MDM2 expressions in progressive OSF. Expressions of COX-2, p53, and MDM2 increased with OSF progression. There was a strong association between COX-2 overexpression and recurrence of oral squamous cell carcinoma (P < 0.001) and a positive relation between increased MDM2 expression and failure of radiotherapy (P = 0.007). These findings suggest that COX-2 is an important marker of disease progression and that MDM2 expression is useful for treatment planning.
authors.affiliation: Department of Oral and Maxillofacial Pathology and Microbiology, Manipal College of Dental Sciences, Manipal University.
authors.forename: Pratik N
authors.initials: PN
authors.lastname: Patel
authors.forename: Aatish
authors.initials: A
authors.lastname: Thennavan
authors.forename: Subhalakshmi
authors.initials: S
authors.lastname: Sen
authors.forename: Chetana
authors.initials: C
authors.lastname: Chandrashekar
authors.forename: Raghu
authors.initials: R
authors.lastname: Radhakrishnan
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009914:Oral Submucous Fibrosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: D016159:Tumor Suppressor Protein p53; D051546:Cyclooxygenase 2; D051736:Proto-Oncogene Proteins c-mdm2