title: Circulating Dickkopf-1 in hypoxic ischemic neonates.
abstract: OBJECTIVE
  The current study aimed to determine the serum level of Dickkopf-1 (Dkk-1) in peripheral blood of neonates with hypoxic ischemic encephalopathy (HIE).
  
  
  METHODS
  We measured serum levels of Dkk-1 by ELISA in neonates with HIE (n = 20) within 24 h from symptom onset and in healthy controls (n = 20).
  
  
  RESULTS
  Dkk-1 serum levels increased significantly in HIE neonates than in healthy control. DKK-1 serum levels increased significantly in HIE neonates with convulsion, using multiple anti-convulsant drugs and those complicated with cranial ultrasound changes. Serum DKK-1 levels increased significantly in severe HIE patients.
  
  
  CONCLUSIONS
  Our study provides for the first time the evidence of releasing Dkk-1 into the circulation of neonates with HIE with higher level in severe degree.
authors.affiliation: a Department of Pediatrics and.
authors.forename: Ehab A M
authors.initials: EA
authors.lastname: Albanna
authors.affiliation: b Department of Clinical Pathology , Zagazig University , Zagazig , Egypt.
authors.forename: Hanan S
authors.initials: HS
authors.lastname: Ahmed
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood* / Q000151:congenital / Q000175:diagnosis; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood* / Q000175:diagnosis; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins
keywords: Apgar; ELISA; NRP; blood gases; sequel