title: Management of varicella-zoster virus primary infection during pregnancy: A national survey of practice.
abstract: BACKGROUND
  Varicella (VZV) infection in pregnancy can result in serious outcomes: maternal pneumoniae irrespective of the term of pregnancy, and lead to congenital varicella syndrome before 18 weeks of gestation and neonatal varicella. There are between 350 and 500 cases a year in France. Until now, there have been no scientific obstetrical guidelines for clinical practice in France for VZV infection during pregnancy.
  
  
  OBJECTIVE
  To evaluate health care providers' knowledge and practices concerning varicella infection during pregnancy in France.
  
  
  METHODS
  An anonymous survey on VZV infection was sent by e-mail to gynecologists-obstetricians and midwives. We evaluated their knowledge and practices concerning VZV transmission, maternal varicella, congenital varicella syndrome, neonatal varicella and prevention.
  
  
  RESULTS
  The survey was completed by 271 professionals: gynecologists (161/271; 60%) and midwives (110/271; 40%). Among 20 items, 5 were multiple choice questions. 29 correct answers were expected. Scores ranged from 6/29 to 28/29 (mean score: 17.44/29).
  
  
  CONCLUSIONS
  The consequences of VZV primary infection in pregnancy are poorly known. We reveal a diversity of management among practitioners in our study population, not always in accordance with the international scientific literature or with the guidelines of other countries. Health care providers should update their knowledge of varicella infection during pregnancy. The publication of national guidelines could help to achieve this objective.
authors.affiliation: Service de Gynécologie-obstétrique, Centre hospitalier intercommunal de Poissy/ Saint- Germain-en-Laye, Poissy 78300, France; Université Paris Ouest, Saint-Quentin en Yvelines, 78190, France.
authors.forename: G
authors.initials: G
authors.lastname: Benoit
authors.affiliation: Service de Gynécologie-obstétrique, Centre hospitalier intercommunal de Poissy/ Saint- Germain-en-Laye, Poissy 78300, France; Université Paris Ouest, Saint-Quentin en Yvelines, 78190, France.
authors.forename: C
authors.initials: C
authors.lastname: Etchemendigaray
authors.affiliation: Service de gynécologie obstétrique et médecine de la reproduction, Hôpital Foch, 40 Rue Worth, 92120 Suresnes, France.
authors.forename: H T
authors.initials: HT
authors.lastname: Nguyen-Xuan
authors.affiliation: Paris-Sud University, AP-HP, Hôpital Paul Brousse, Virology Department, Univ Paris-Sud, UMR-S 785, INSERM U785, Villejuif 94804, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Vauloup-Fellous
authors.affiliation: Service de gynécologie obstétrique et médecine de la reproduction, Hôpital Foch, 40 Rue Worth, 92120 Suresnes, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Ayoubi
authors.affiliation: Service de gynécologie obstétrique et médecine de la reproduction, Hôpital Foch, 40 Rue Worth, 92120 Suresnes, France. Electronic address: o.picone@hopital-foch.org.
authors.forename: O
authors.initials: O
authors.lastname: Picone
mesh_terms: D000293:Adolescent; D000328:Adult; D001291:Attitude of Health Personnel; D002644:Chickenpox / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D005602:France; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000628:therapy* / Q000821:virology; D011361:Professional Competence; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Chickenpox; Congenital varicella syndrome; Immunoglobulin; Neonatal varicella; Pregnancy