title: Synthesis and biological activity of polyprenols.
abstract: The polyprenols and their derivatives are highlighted in this study. These lipid linear polymers of isoprenoid residues are widespread in nature from bacteria to human cells. This review primarily presents the synthesis and biological activities of polyprenyl derivatives. Attention is focused on the synthesis and biological activity of dolichols, polyprenyl ester derivatives and polyprenyl amines. Other polyprenyl derivatives, such as oxides of polyprenols, aromatic polyprenols, polyprenyl bromide and polyprenyl sulphates, are mentioned. It is noted that polyprenyl phosphates and polyprenyl-linked glycosylation have better antibacterial, gene therapy and immunomodulating performance, whereas polyprenyl amines have better for antibacterial and antithrombotic activity. Dolichols, polyprenyl acetic esters, polyprenyl phosphates and polyprenyl-linked glycosylation have pharmacological anti-tumour effects. Finally, the postulated prospect of polyprenols and their derivatives are discussed. Further in vivo studies on the above derivatives are needed. The compatibility of polyprenols and their derivatives with other drugs should be studied, and new preparations of polyprenyl derivatives, such as hydrogel glue and release-controlled drugs, are suggested for future research and development.
authors.affiliation: Institute of Chemical Industry of Forest Products, CAF, Nanjing, Jiangsu Province 210042, China; National Engineering Lab. for Biomass Chemical Utilization, Key and Open lab. of Forest Chemical Engineering, SFA, Nanjing, Jiangsu Province 210042, China; Key Lab. of Biomass Energy and Material, Nanjing, Jiangsu Province 210042, China; Beijing Forestry University, Beijing 100083, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Institute of Chemical Industry of Forest Products, CAF, Nanjing, Jiangsu Province 210042, China; National Engineering Lab. for Biomass Chemical Utilization, Key and Open lab. of Forest Chemical Engineering, SFA, Nanjing, Jiangsu Province 210042, China; Key Lab. of Biomass Energy and Material, Nanjing, Jiangsu Province 210042, China. Electronic address: l_x_huang@163.com.
authors.forename: Lixin
authors.initials: L
authors.lastname: Huang
authors.affiliation: Institute of Chemical Industry of Forest Products, CAF, Nanjing, Jiangsu Province 210042, China; National Engineering Lab. for Biomass Chemical Utilization, Key and Open lab. of Forest Chemical Engineering, SFA, Nanjing, Jiangsu Province 210042, China; Key Lab. of Biomass Energy and Material, Nanjing, Jiangsu Province 210042, China.
authors.forename: Caihong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Institute of Chemical Industry of Forest Products, CAF, Nanjing, Jiangsu Province 210042, China; National Engineering Lab. for Biomass Chemical Utilization, Key and Open lab. of Forest Chemical Engineering, SFA, Nanjing, Jiangsu Province 210042, China; Key Lab. of Biomass Energy and Material, Nanjing, Jiangsu Province 210042, China.
authors.forename: Pujun
authors.initials: P
authors.lastname: Xie
authors.affiliation: Institute of Chemical Industry of Forest Products, CAF, Nanjing, Jiangsu Province 210042, China; National Engineering Lab. for Biomass Chemical Utilization, Key and Open lab. of Forest Chemical Engineering, SFA, Nanjing, Jiangsu Province 210042, China; Key Lab. of Biomass Energy and Material, Nanjing, Jiangsu Province 210042, China.
authors.forename: Yaolei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Chemical Industry of Forest Products, CAF, Nanjing, Jiangsu Province 210042, China; National Engineering Lab. for Biomass Chemical Utilization, Key and Open lab. of Forest Chemical Engineering, SFA, Nanjing, Jiangsu Province 210042, China; Key Lab. of Biomass Energy and Material, Nanjing, Jiangsu Province 210042, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Ding
authors.affiliation: Beijing Forestry University, Beijing 100083, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
mesh_terms: D004286:Dolichols / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000737:chemistry* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D010944:Plants / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004286:Dolichols; D008055:Lipids; D010936:Plant Extracts; D013729:Terpenes
keywords: Biological activity; Derivatives; Dolichols; Polyprenyl