title: A severe case of co-infection with Enterovirus 71 and vaccine-derived Poliovirus type II.
abstract: Enterovirus 71 (EV71) is often identified as the primary pathogen that directly leads to severe cases of HFMD, whereas the association between other enteroviruses and EV71 infection remains largely unclear. Here we report a rare case of a 5-year-old boy co-infected with EV71 and vaccine-derived Poliovirus (VDPV) type II, which were identified based on PCR and sequence analysis results and clinical symptoms and were characterized on CT. We determined that the EV71 strain belongs to the C4 subtype, and the VDPV II strain was closely genetically related to the reference Sabin type II strain. This report may improved our understanding of the clinical significance of the associations between clinical signs and the infectious properties of the involved pathogens.
authors.affiliation: Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Kunming 650118, China.
authors.forename: Shaohui
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Infectious Diseases of Kunming Children's Hospital, Kunming 650,034, China.
authors.forename: Zengqing
authors.initials: Z
authors.lastname: Du
authors.affiliation: Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Kunming 650118, China.
authors.forename: Min
authors.initials: M
authors.lastname: Feng
authors.affiliation: Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Kunming 650118, China.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Che
authors.affiliation: Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Kunming 650118, China. Electronic address: imbcams.lq@gmail.com.
authors.forename: Qihan
authors.initials: Q
authors.lastname: Li
mesh_terms: D002675:Child, Preschool; D060085:Coinfection / Q000175:diagnosis* / Q000473:pathology*; D029821:Enterovirus A, Human / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008297:Male; D017955:Poliovirus / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
keywords: Co-infection; Enterovirus 71; Hand foot and mouth diseases; Poliovirus type II