title: The Journey to Establish CGRP as a Migraine Target: A Retrospective View.
abstract: In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our understanding of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigeminovascular system and its role in migraine. The discovery of the presence and function of CGRP and other neuropeptides in the cerebral vasculature and its sensory innervation is described. He relates the seminal finding that CGRP is uniquely released during migraine and the journey to develop blockers of CGRP effects. Now, over 30 years since its discovery, CGRP has become the target for a number of promising novel treatments for migraine patients.
authors.affiliation: Department of Medicine, Institute of Clinical Sciences, Lund University and Lund University Hospital, Lund, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Edvinsson
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000266:history* / Q000502:physiology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008881:Migraine Disorders / Q000266:history* / Q000503:physiopathology*; D009462:Neurology / Q000266:history*; D012189:Retrospective Studies
chemical_list: D015740:Calcitonin Gene-Related Peptide
keywords: CGRP; migraine; review