title: Combined Training Reduces Subclinical Inflammation in Obese Middle-Age Men.
abstract: OBJECTIVE
  We investigated the effects of 24 wk of combined training on proinflammatory and anti-inflammatory markers associated with obesity in obese middle-age men.
  
  
  METHODS
  Thirty obese men (48.73 ± 1.04 yr; body mass index, 31.00 ± 0.29 kg·m) underwent 24 wk of combined training [CT (N = 17), aerobic (50%-85% of V˙O2peak) and resistance (6-10 maximum repetition [RM]) training)] three times per week, 60 min per session, or a control group (N = 13). Anthropometric measures, maximal strength for leg press and bench press, peak oxygen uptake (V˙O2peak) and serum concentrations of C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), IL-10, IL-15, resistin, leptin, and adiponectin were determined before (M1) and after 8 (M2), 16 (M3), and 24 (M4) wk of the experimental design.
  
  
  RESULTS
  Significant increases were observed in the maximal strength for bench press and leg press, V˙O2peak, and serum concentrations of adiponectin and IL-15 for CT. Concomitantly, significant decreases were observed in percentage body fat and serum concentrations of CRP, resistin, and leptin for CT after the experimental period.
  
  
  CONCLUSIONS
  Twenty-four weeks of moderate- to high-intensity CT reduced markers of subclinical inflammation associated with obesity and improved insulin resistance and functional capabilities of obese middle-age men, regardless of dietary intervention and weight loss.
authors.affiliation: 1Exercise Physiology Laboratory - FISEX, Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, BRAZIL; 2Departament of Physical Education, State University of Maringa (UEM), Maringa, BRAZIL; 3Integrated Metropolitan College of Campinas (METROCAMP), Campinas, BRAZIL; and 4Department of Physical Education (DEFMH), Center of Biological and Health Sciences (CCBS), Federal University of São Carlos (UFSCar), São Carlos, BRAZIL.
authors.forename: Diego T
authors.initials: DT
authors.lastname: Brunelli
authors.forename: Mara Patrícia T
authors.initials: MP
authors.lastname: Chacon-Mikahil
authors.forename: Arthur F
authors.initials: AF
authors.lastname: Gáspari
authors.forename: Wendell Arthur
authors.initials: WA
authors.lastname: Lopes
authors.forename: Valéria
authors.initials: V
authors.lastname: Bonganha
authors.forename: Ivan Luiz P
authors.initials: IL
authors.lastname: Bonfante
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Bellotto
authors.forename: Cleiton Augusto
authors.initials: CA
authors.lastname: Libardi
authors.forename: Cláudia Regina
authors.initials: CR
authors.lastname: Cavaglieri
mesh_terms: D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D050218:Body Fat Distribution; D002097:C-Reactive Protein / Q000378:metabolism; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D007333:Insulin Resistance; D019409:Interleukin-15 / Q000097:blood; D007866:Leg / Q000502:physiology; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D009765:Obesity / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D010101:Oxygen Consumption; D010809:Physical Fitness; D055070:Resistance Training; D052243:Resistin / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D019409:Interleukin-15; D020738:Leptin; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein