title: Potential adverse effects of prophylactic bilateral salpingo-oophorectomy on skin aging in premenopausal women undergoing hysterectomy for benign conditions.
abstract: OBJECTIVE
  This study aimed to assess the effects of hysterectomy and bilateral salpingo-oophorectomy (BSO)--compared with the effects of hysterectomy alone--on skin aging in premenopausal women undergoing hysterectomy for benign conditions.
  
  
  METHODS
  One hundred thirty-five premenopausal women who underwent hysterectomy with BSO were compared with a control group of women who underwent hysterectomy alone based on skin parameters (including wrinkling, laxity/sagging, and texture/dryness) and Skindex-29 questionnaire scores. The inclusion criteria were as follows: aged between 40 and 50 years, follicle-stimulating hormone level lower than 40 mIU/mL, undergoing hysterectomy with or without BSO for benign conditions, and not receiving estrogen or progesterone treatment. The exclusion criteria were as follows: adrenocortical hyperplasia or Cushing's syndrome; use of corticosteroids for autoimmune diseases; malignancy, connective tissue diseases (eg, Ehlers-Danlos syndrome), or dermatological diseases (eg, lichen sclerosus); or regular use of medications known to interfere with the condition of the skin.
  
  
  RESULTS
  All skin parameters in the hysterectomy group and the hysterectomy with BSO group worsened on weeks 24 and 48. Laxity/sagging and texture/dryness scores on weeks 24 and 48 were significantly worse in the BSO group; laxity/sagging and texture/dryness scores continued to worsen between 24 and 48 weeks. Scores for the Skindex-29 questionnaire emotion and symptom subscales were significantly higher in the BSO group compared with the non-BSO group.
  
  
  CONCLUSIONS
  Prophylactic BSO during hysterectomy is a significant independent risk factor for worsening skin laxity/sagging and texture/dryness in premenopausal women undergoing hysterectomy for benign conditions. Prophylactic BSO in the presence of dermatological conditions is also associated with reduced quality of life.
authors.affiliation: 1Department of Gynecology and Obstetrics, Izmir Tepecik Teaching and Research Hospital, Izmir, Turkey 2Department of Gynecology and Obstetrics, Istanbul Haliç University, Istanbul, Turkey 3Department of Gynecology and Obstetrics, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey 4Department of Dermatology, Izmir Kent Hospital, Izmir, Turkey 5Department of Dermatology, Izmir Tepecik Teaching and Research Hospital, Izmir, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Töz
authors.forename: Aykut
authors.initials: A
authors.lastname: Özcan
authors.forename: Deniz
authors.initials: D
authors.lastname: Balsak
authors.forename: Muhittin Eftal
authors.initials: ME
authors.lastname: Avc
authors.forename: Arzu Görgülü
authors.initials: AG
authors.lastname: Eraslan
authors.forename: Didem Didar
authors.initials: DD
authors.lastname: Balc
mesh_terms: D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects*; D017697:Premenopause / Q000502:physiology*; D065286:Prophylactic Surgical Procedures / Q000009:adverse effects*; D012307:Risk Factors; D012489:Salpingostomy / Q000009:adverse effects*; D015595:Skin Aging / Q000502:physiology*
chemical_list: D005640:Follicle Stimulating Hormone