title: Follicular Dendritic Cell Sarcoma: Cytogenetics and pathological findings.
abstract: Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm with a non-specific and insidious presentation further complicated by the difficult diagnostic and therapeutic assessment. It has a low to intermediate risk of recurrence and metastasis. Unlike other soft tissue sarcomas or histiocytic and dendritic cell neoplasms, cytogenetic studies are very limited in FDCS cases. Although no specific chromosomal marker has yet been established, complex aberrations and different ploidy types have been documented. We report the case of a 39-year-old woman with FDCS who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in February 2013. Ultrastructural, immunophenotypical and histological findings are reported. In addition, karyotypic findings showed deletions of the chromosomes 1p, 3q, 6q, 7q, 8q and 11q. To the best of the authors' knowledge, these have not been reported previously in this tumour. Techniques such as spectral karyotyping may help to better characterise chromosomal abnormalities in this type of tumour.
authors.affiliation: Department of Genetics, College of Medicine & Health Sciences, Sultan Qaboos University;
authors.forename: Achandira M
authors.initials: AM
authors.lastname: Udayakumar
authors.affiliation: Departments of Pathology, Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Maiya
authors.initials: M
authors.lastname: Al-Bahri
authors.affiliation: Medicine, Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Ikram A
authors.initials: IA
authors.lastname: Burney
authors.affiliation: Departments of Pathology, Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Al-Haddabi
keywords: Case Report; Chromosomal Aberrations; Cytogenetics; Fine Needle Aspiration; Follicular Dendritic Cell Sarcoma; Karyotyping; Oman