title: Multifaceted approach for the fabrication of metallomicelles and metallic nanoparticles using solvophobic bisdodecylaminepalladium (II) chloride as precursor.
abstract: A one-pot synthesis of solvophobic bisdodecylaminepalladium(II) chloride (complex 1) was performed. Complex 1 was characterized using X-ray crystallography and other techniques, namely, mass spectrometry, Fourier transform infrared, NMR, elemental analysis, etc. A multifaceted approach was taken to explore the potential applications of complex 1. The micellization ability of complex 1 was estimated using conductivity method in n-alcohols. The metallomicelles are formed in alcohols, and the process is thermodynamically spontaneous in nature. Using complex 1 as precursor, palladium (Pd) nanoparticles were fabricated using two-phase redox method, where reduction is being performed in core of metallomicelles formed by complex 1 in dichloromethane (DCM). The micellization in DCM is confirmed by small-angle X-ray scattering (SAXS). The SAXS measurements reveal that the micellar of core 4-5 nm is being formed, which further controls the size of nanoparticle. This approach was advantageous in terms of size control, methodology, and yield. Pd nanoparticles were characterized using transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and UV-visible spectroscopy and were also screened for bovine serum albumin interactions. Complex 1 and Pd nanoparticles were found to possess antimicrobial property with broad spectrum and are active against bacteria and fungi. The cytotoxicity analyses were performed over healthy cells (Vero cell lines extracted from kidney of green monkey), and the results reveal IC50 value of 10 μg/mL for complex 1.
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University , Chandigarh 160 014, India.
authors.forename: Ganga Ram
authors.initials: GR
authors.lastname: Chaudhary
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University , Chandigarh 160 014, India.
authors.forename: Prabjot
authors.initials: P
authors.lastname: Singh
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University , Chandigarh 160 014, India.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University , Chandigarh 160 014, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Mehta
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science & Technology , Hisar 125 001, Haryana India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Bio and Nano Technology, Guru Jambheshwar University of Science & Technology , Hisar 125 001, Haryana India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Dilbaghi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D002522:Chlorocebus aethiops; D007711:Klebsiella pneumoniae / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008823:Micelles; D003904:Mitosporic Fungi / Q000187:drug effects; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D014709:Vero Cells / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D008823:Micelles; D009944:Organoplatinum Compounds; C000607933:bisdodecylaminepalladium(II) chloride; D010165:Palladium