title: Short Communication: The Distribution of Potential N-Linked Glycosylation Sites in Gp120 Differs Among Major HIV-1 Subtypes Circulating in China.
abstract: CRF01_AE shows an obvious sexual transmission advantage over other major HIV-1 subtypes circulating in China. Previous studies showed that the presence or absence of potential N-linked glycosylation sites (PNGSs) in variable loops might affect HIV-1 transmission; it is therefore of interest to compare the distribution of potential PNGSs on envelopes of different subtypes circulating in China. Compared to CRF07_BC, CRF08_BC, B, and B' subtypes isolated in China, CRF01_AE subtypes isolated from both China and outside China had significantly fewer PNGSs in total and in V2/V4, while they had significantly more PNGSs in V5. HIV-1 subtype CRF01_AE has a unique PNGS distribution pattern in Gp120, which may contribute to its advantage in sexual transmission in China.
authors.affiliation: 1 Shanghai Public Health Clinical Center, Fudan University , Shanghai, China .|2 Wenzhou Medical University , Wenzhou, China .
authors.forename: Yin
authors.initials: Y
authors.lastname: Shi
authors.affiliation: 3 Hubei Provincial Center for Disease Control and Prevention , Wuhan, China .
authors.forename: Yanmeng
authors.initials: Y
authors.lastname: Feng
authors.affiliation: 1 Shanghai Public Health Clinical Center, Fudan University , Shanghai, China .
authors.forename: Xiangqing
authors.initials: X
authors.lastname: Ding
authors.affiliation: 1 Shanghai Public Health Clinical Center, Fudan University , Shanghai, China .|2 Wenzhou Medical University , Wenzhou, China .
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: 1 Shanghai Public Health Clinical Center, Fudan University , Shanghai, China .|2 Wenzhou Medical University , Wenzhou, China .
authors.forename: Jianqing
authors.initials: J
authors.lastname: Xu
authors.affiliation: 1 Shanghai Public Health Clinical Center, Fudan University , Shanghai, China .
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Wan
mesh_terms: D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006031:Glycosylation; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D010802:Phylogeny; D011134:Polysaccharides / Q000378:metabolism*; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational
chemical_list: D015699:HIV Envelope Protein gp120; D011134:Polysaccharides