title: The effects of chronic administration of nandrolone decanoate on redox status in exercised rats.
abstract: For the past 40 years, anabolic-androgenic steroids have been used by a wide variety of athletes with the hope of improving their training, endurance, and performance. The aim of this study was to examine the chronic effects of nandrolone decanoate (20 mg/kg, s.c, Deca-Durabolin DECA(®)) on oxidative stress biomarkers in the hearts of sedentary and exercised rats. The male Wistar albino rats (n = 180, four groups with three subgroups, 15 per subgroup, age 10 weeks, body mass 200-220 g) were sacrificed, and in the collected samples of blood, the following markers of oxidative stress were measured spectrophotometrically: (1) index of lipid peroxidation (measured as TBARS-thiobarbituric acid reactive substances); (2) nitrites (NO2 (-)); (3) hydrogen peroxide (H2O2); (4) superoxide anion radical (O2 (-)), and superoxide dismutase, catalase, and glutathione reductase. The results clearly show that the impact of ND alone, or in combination with physical training in general, is mildly pro-oxidative. The chronic physical training probably induces the protective antioxidant enzyme system , which may be of clinical interest when faced with overdosage of this drug.
authors.affiliation: Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Nikolic
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Zivkovic
authors.affiliation: College of Health Studies in Cuprija, Cuprija, Serbia.
authors.forename: Maja
authors.initials: M
authors.lastname: Jevdjevic
authors.affiliation: School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Marko
authors.initials: M
authors.lastname: Djuric
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Srejovic
authors.affiliation: Institute of Medical Physiology "Richard Burian", School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Dragan
authors.initials: D
authors.lastname: Djuric
authors.affiliation: Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Nevena
authors.initials: N
authors.lastname: Jeremic
authors.affiliation: Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Dusan
authors.initials: D
authors.lastname: Djuric
authors.affiliation: Department of Human Pathology, 1st Moscow State Medical University I.M. Sechenov, Moscow, Russia.
authors.forename: Sergey
authors.initials: S
authors.lastname: Bolevich
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia. drvladakgbg@yahoo.com.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Jakovljevic
mesh_terms: D045930:Anabolic Agents / Q000008:administration & dosage*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077603:Nandrolone Decanoate; D010084:Oxidation-Reduction; D010805:Physical Conditioning, Animal; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D045930:Anabolic Agents; D009277:Nandrolone; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D000077603:Nandrolone Decanoate
keywords: Exercise; Nandrolone decanoate; Rats; Redox status