title: Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle.
abstract: Exercise training enhances physical performance and confers health benefits, largely through adaptations in skeletal muscle. Mitochondrial adaptation, encompassing coordinated improvements in quantity (content) and quality (structure and function), is increasingly recognized as a key factor in the beneficial outcomes of exercise training. Exercise training has long been known to promote mitochondrial biogenesis, but recent work has demonstrated that it has a profound impact on mitochondrial dynamics (fusion and fission) and clearance (mitophagy), as well. In this review, we discuss the various mechanisms through which exercise training promotes mitochondrial quantity and quality in skeletal muscle.
authors.affiliation: Center for Skeletal Muscle Research, Robert M. Berne Cardiovascular Research Center, Department of Medicine, Department of Pharmacology, and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Drake
authors.affiliation: Center for Skeletal Muscle Research, Robert M. Berne Cardiovascular Research Center, Department of Medicine, Department of Pharmacology, and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Wilson
authors.affiliation: Center for Skeletal Muscle Research, Robert M. Berne Cardiovascular Research Center, Department of Medicine, Department of Pharmacology, and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia, USA zhen.yan@virginia.edu.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yan
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000378:metabolism* / Q000628:therapy; D018482:Muscle, Skeletal / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors
keywords: PGC-1α; biogenesis; mitophagy; remodeling