title: Endocrine mucin-producing sweat gland carcinoma of the eyelid.
abstract: An elderly woman was incidentally noted to have a nodular mass on the upper eyelid, whilst under investigation for cataracts. Punch biopsy of this presumed basal cell carcinoma revealed it to be endocrine mucin-producing sweat gland carcinoma (EMPSGC). The tumour extended to the deep dermal layer and comprised solid nests with foci of cystic and papillary change, and additional cytoplasmic and focal extracellular mucin deposits. Immunohistochemistry confirmed epithelial lineage and neuroendocrine differentiation, and adjacent tissue invasion. The tumour was excised completely with Mohs micrographic surgery with no recurrence after 8 months. EMPSGC is a low-grade sweat gland carcinoma with variable neuroendocrine differentiation, a solid, papillary, or cystic growth pattern, and a predilection for the eyelid of elderly women [Am J Surg Pathol 29:1330-1339, 2005]. There have been 54 previously documented cases of EMPSCG. We report an additional case and review the literature.
authors.affiliation: Discipline of Ophthalmology and Visual Sciences, The University of Adelaide and the South Australian Institute of Ophthalmology, Adelaide, Australia. anne.collinson@student.adelaide.edu.au.
authors.forename: Anne C
authors.identifier: http://orcid.org/0000-0002-0897-4673
authors.initials: AC
authors.lastname: Collinson
authors.affiliation: Discipline of Ophthalmology and Visual Sciences, The University of Adelaide and the South Australian Institute of Ophthalmology, Adelaide, Australia.
authors.forename: Michelle T
authors.initials: MT
authors.lastname: Sun
authors.affiliation: Adelaide Pathology Partners, Mile End, Adelaide, SA, Australia.
authors.forename: Craig
authors.initials: C
authors.lastname: James
authors.affiliation: Department of Dermatology, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, 5000, Australia.
authors.forename: Shyamala C
authors.initials: SC
authors.lastname: Huilgol
authors.affiliation: Discipline of Ophthalmology and Visual Sciences, The University of Adelaide and the South Australian Institute of Ophthalmology, Adelaide, Australia.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Selva
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D005142:Eyelid Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D009077:Mucins / Q000378:metabolism; D013544:Sweat Gland Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D009077:Mucins
keywords: EMPSGC; Endocrine mucin-producing sweat gland carcinoma; Eyelid neoplasms; Oculoplastics; Sweat gland neoplasms