title: Miller-Fisher syndrome associated with unilateral cerebral white matter lesions.
abstract: Miller-Fisher syndrome (MFS) is characterized by classical triad of ophthalmoplegia, ataxia and areflexia. The involvement of cerebral white matter in MFS is very rare. We report a typical MFS patient whose brain MRI showed unilateral and extensive involvement in cerebral white matter. We also found mild pleocytosis and raised protein concentration in cerebrospinal fluid. Deficits resolved completely after treatment with intravenous immunoglobulins. Subsequent brain MRI shows cavity formation in involved white matter.
authors.affiliation: Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, PR China. Electronic address: flowingblue@126.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D004172:Diplopia / Q000209:etiology; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006801:Humans; D007964:Leukocytosis; D008279:Magnetic Resonance Imaging; D008297:Male; D019846:Miller Fisher Syndrome / Q000134:cerebrospinal fluid / Q000150:complications / Q000473:pathology*; D059906:Neuroimaging; D012021:Reflex, Abnormal; D066127:White Matter / Q000473:pathology*
chemical_list: D002556:Cerebrospinal Fluid Proteins
keywords: Central nervous system; Miller-Fisher syndrome; Pleocytosis