title: Influence of embryo culture medium on incidence of ectopic pregnancy in in vitro fertilization.
abstract: OBJECTIVE
  To explore the effect of type of media used to culture embryos for IVF on the incidence of ectopic pregnancy (EP).
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  University-affiliated IVF center.
  
  
  METHODS
  The retrospective analysis involved 23,481 women who underwent IVF-ET cycles between 2011 and 2013.
  
  
  METHODS
  None.
  
  
  METHODS
  There was an association between EP and the culture medium.
  
  
  RESULTS
  During 23,481 fresh transfer cycles, 364 patients were diagnosed with EP. The EP to clinical pregnancy rate was 3.01% in the G5 group, 3.89% in the G5 Plus group, and 4.04% in the Global group. The EP to clinical pregnancy rates were significantly higher in the G5 Plus and Global groups than in the G5 group. After adjusting for confounding factors, the incidence of EP was significantly associated with the G5 Plus and Global media.
  
  
  CONCLUSIONS
  Our results showed that there is an association between incidence of EP and the culture medium. The rates of EP to clinical pregnancy were significantly higher in the G5 Plus and Global media than in the G5 medium.
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Lin
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Chi
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Xiulian
authors.initials: X
authors.lastname: Ren
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Yang
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China. Electronic address: jie.qiao@263.net.
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003470:Culture Media / Q000009:adverse effects*; D046149:Embryo Culture Techniques; D004624:Embryo Transfer; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D006801:Humans; D015994:Incidence; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D003470:Culture Media
keywords: IVF-ET; ectopic pregnancy; embryo culture medium