title: Heart and Brain Interactions--the Akershus Cardiac Examination (ACE) 1950 Study Design.
abstract: OBJECTIVE
  The aim of the Akershus Cardiac Examination (ACE) 1950 Study is to investigate the development and progression of cardiovascular and cerebrovascular disease (CVD/CeVD) in an extensively characterized age cohort of middle-aged subjects with longitudinal long-term follow-up.
  
  
  METHODS
  The ACE 1950 Study is a prospective, population-based, age-cohort study of all men and women born in 1950 in Akershus County, Norway. The study involves a comprehensive baseline examination, especially for CVD/CeVD, including advanced ultrasound imaging and biobanking ("deep phenotyping"). We expect to obtain an inclusion rate of > 60% from the total study population of 5,827 eligible subjects. Enrollment will be completed during 2015.
  
  
  CONCLUSIONS
  The ACE 1950 Study will have potential to generate new and relevant insight into identification of subclinical disease progression. Extensive phenotyping will enable identification of novel disease markers and mechanisms for subclinical disease, which can prove important for future disease prevention.
authors.affiliation: a Department of Medical Research , Baerum Hospital, Vestre Viken Hospital Trust , Norway.|c Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Trygve
authors.initials: T
authors.lastname: Berge
authors.affiliation: b Division of Medicine, Akershus University Hospital , Lørenskog , Norway.|c Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Thea
authors.initials: T
authors.lastname: Vigen
authors.affiliation: b Division of Medicine, Akershus University Hospital , Lørenskog , Norway.|c Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Mohammad Osman
authors.initials: MO
authors.lastname: Pervez
authors.affiliation: a Department of Medical Research , Baerum Hospital, Vestre Viken Hospital Trust , Norway.|c Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Haakon
authors.initials: H
authors.lastname: Ihle-Hansen
authors.affiliation: b Division of Medicine, Akershus University Hospital , Lørenskog , Norway.|c Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Magnus Nakrem
authors.initials: MN
authors.lastname: Lyngbakken
authors.affiliation: b Division of Medicine, Akershus University Hospital , Lørenskog , Norway.|c Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Omland
authors.affiliation: b Division of Medicine, Akershus University Hospital , Lørenskog , Norway.|c Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Pål
authors.initials: P
authors.lastname: Smith
authors.affiliation: b Division of Medicine, Akershus University Hospital , Lørenskog , Norway.|c Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Kjetil
authors.initials: K
authors.lastname: Steine
authors.affiliation: b Division of Medicine, Akershus University Hospital , Lørenskog , Norway.|c Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Helge
authors.initials: H
authors.lastname: Røsjø
authors.affiliation: a Department of Medical Research , Baerum Hospital, Vestre Viken Hospital Trust , Norway.
authors.forename: Arnljot
authors.initials: A
authors.lastname: Tveit
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009664:Norway / Q000453:epidemiology; D018579:Patient Selection; D010641:Phenotype; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors; D018401:Sample Size; D013997:Time Factors
chemical_list: D015415:Biomarkers
keywords: atrial fibrillation; cardiovascular epidemiology; cerebrovascular epidemiology; cognitive function; cohort study; heart failure; stroke