title: Urinary myo-inositol levels in Japanese schoolchildren with normal glucose tolerance.
abstract: BACKGROUND
  Urinary myo-inositol (UMI) level is elevated in adult diabetic patients, and also increases after glucose loading. However, the relationship between UMI and plasma glucose levels in children is unknown. We aimed to assess whether UMI is a practical marker for glucose intolerance in children or not.
  
  
  METHODS
  In Study 1 (328 schoolchildren), fasting and postprandial UMI were measured, with ΔUMI defined as the difference between fasting and postprandial UMI levels. In Study 2, oral glucose tolerance tests and UMI measurements were conducted in 18 children with suspected having diabetes.
  
  
  RESULTS
  For Study 1, ΔUMI was observed [-0.65 (-3.9, 1.35) mg/g creatinine]. For Study 2, children with diabetes or impaired glucose tolerance had a significantly higher ΔUMI than children with normal glucose tolerance.
  
  
  CONCLUSIONS
  These studies demonstrated the normal range of UMI in children and possibility of a novel biomarker for early detection of glucose intolerance in children.
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Satake
authors.forename: Rie
authors.initials: R
authors.lastname: Matsushita
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Kitsuda
authors.forename: Kohnosuke
authors.initials: K
authors.lastname: Ohtaka
authors.forename: Eiko
authors.initials: E
authors.lastname: Nagata
authors.forename: Rie
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Sano
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Fujisawa
authors.forename: Toshiki
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Takehiko
authors.initials: T
authors.lastname: Ohzeki
mesh_terms: D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007294:Inositol / Q000652:urine*; D007564:Japan; D008297:Male
chemical_list: D007294:Inositol