title: The double trouble of metabolic diseases: the diabetes-cancer link.
abstract: The recent recognition of the clinical association between type 2 diabetes (T2D) and several types of human cancer has been further highlighted by reports of antidiabetic drugs treating or promoting cancer. At the cellular level, a plethora of molecules operating within distinct signaling pathways suggests cross-talk between the multiple pathways at the interface of the diabetes-cancer link. Additionally, a growing body of emerging evidence implicates homeostatic pathways that may become imbalanced during the pathogenesis of T2D or cancer or that become chronically deregulated by prolonged drug administration, leading to the development of cancer in diabetes and vice versa. This notion underscores the importance of combining clinical and basic mechanistic studies not only to unravel mechanisms of disease development but also to understand mechanisms of drug action. In turn, this may help the development of personalized strategies in which drug doses and administration durations are tailored to individual cases at different stages of the disease progression to achieve more efficacious treatments that undermine the diabetes-cancer association.
authors.affiliation: Wolfson Institute for Biomedical Research, University College London, London WC1E6BT, UK.
authors.forename: Slavica
authors.initials: S
authors.lastname: Tudzarova
authors.affiliation: Department of Molecular Physiology, Pharmacology and Biotechnology, Division of Biology and Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02912 Department of Chemistry and Forensic Sciences, College of Sciences and Technology, Savannah State University, Savannah, GA 41404 Mahasin_Osman@brown.edu mo28@cornell.edu osmanm@savannahstate.edu.
authors.forename: Mahasin A
authors.initials: MA
authors.lastname: Osman
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D060449:Wnt Signaling Pathway