title: Epidemiological and clinical characteristics of hepatitis B virus in HIV-infected patients in Guangdong, China.
abstract: This study investigated the epidemiological and clinical characteristics of hepatitis B virus (HBV) in HIV-infected adults at the time of antiretroviral therapy (ART) initiation in Guangdong province, China. A total of 2793 HIV-infected adults were enrolled between January 2004 and September 2011. Demographic data and laboratory parameters were collected, HBV-DNA levels were measured, and HBV genotypes were identified before ART initiation. The prevalence of hepatitis B surface antigen (HBsAg) in HIV-infected patients was 13.2%. A total of 266 HIV/HBV co-infected patients and 1469 HIV mono-infected patients were recruited. The median alanine aminotransferase and aspartate aminotransferase levels of HIV/HBV co-infected patients were higher than HIV mono-infected patients (32 U/L vs. 22 U/L, p < 0.001 and 35 U/L vs. 24 U/L, p < 0.001, respectively), whereas the median CD4 cell count of HIV/HBV co-infected patients was lower than HIV mono-infected patients (59 cells/mm(3) vs. 141 cells/mm(3), p < 0.001). The level of CD4 cell count was lower in hepatitis B e-antigen (HBeAg)-positive co-infected patients than HBeAg-negative patients (36 cells/mm(3) vs. 69 cells/mm(3), p = 0.014). A similar result was found in high level of HBV-DNA and low level of HBV-DNA groups (33 cells/mm(3) vs. 89 cells/mm(3), p < 0.001). HBV genotypes were classified as genotypes B and C. Patients infected with genotypes B and C differed significantly in terms of proportion of those who were HBeAg-positive (40.5% vs. 62.2%, p = 0.014). This study indicates a high prevalence of HBsAg in HIV-infected adults in Guangdong. The level of CD4 cell count in HIV/HBV co-infected patients was much lower than HIV mono-infected patients, especially in patients who were HBeAg-positive and had a high level of HBV-DNA. The predominant HBV genotype in HIV/HBV co-infected patients is genotype B.
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Jinan University, Guangzhou, China.
authors.forename: S M
authors.initials: SM
authors.lastname: Huang
authors.affiliation: Number Eight People's Hospital of Guangzhou, Guangzhou Medical University, Guangzhou, China.
authors.forename: W P
authors.initials: WP
authors.lastname: Cai
authors.affiliation: Number Eight People's Hospital of Guangzhou, Guangzhou Medical University, Guangzhou, China.
authors.forename: F Y
authors.initials: FY
authors.lastname: Hu
authors.affiliation: Number Eight People's Hospital of Guangzhou, Guangzhou Medical University, Guangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Lan
authors.affiliation: Number Eight People's Hospital of Guangzhou, Guangzhou Medical University, Guangzhou, China.
authors.forename: B L
authors.initials: BL
authors.lastname: Liao
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Jinan University, Guangzhou, China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Jinan University, Guangzhou, China Number Eight People's Hospital of Guangzhou, Guangzhou Medical University, Guangzhou, China xiaopingtanggz@yahoo.com.
authors.forename: X P
authors.initials: XP
authors.lastname: Tang
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology / Q000821:virology*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012189:Retrospective Studies
chemical_list: D006514:Hepatitis B Surface Antigens
keywords: China; HIV; co-infection; genotype; hepatitis B virus; prevalence