title: Role of Fluorodeoxyglucose PET/Computed Tomography in Targeted Radionuclide Therapy for Endocrine Malignancies.
abstract: This review provides practical guidance for clinicians involved in the management of endocrine malignancies, including endocrinologists, medical oncologists, surgeons and nuclear medicine specialists regarding the indications and use of 2-fluoro-2-deoxy-d-glucose F-18 (FDG) PET/computed tomography (CT), particularly with respect to targeted radionuclide therapy. Key principles of FDG PET/CT for radionuclide therapy are explored in detail using gastroenteropancreatic neuroendocrine tumors as a prototype endocrine malignancy. The relevant literature is reviewed, and practical application in this new and emerging field is highlighted with the use of case examples.
authors.affiliation: Centre for Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Endocrinology Service, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
authors.forename: David A
authors.initials: DA
authors.lastname: Pattison
authors.affiliation: Centre for Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. Electronic address: Michael.Hofman@petermac.org.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Hofman
mesh_terms: D004701:Endocrine Gland Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D019317:Evidence-Based Medicine; D019788:Fluorodeoxyglucose F18; D006801:Humans; D064847:Multimodal Imaging / Q000379:methods; D018579:Patient Selection; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D061089:Radiotherapy, Image-Guided / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: FDG PET/CT; Neuroendocrine tumor; Peptide receptor radionuclide therapy; Radionuclide therapy; Thyroid cancer