title: Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy.
abstract: We report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO3) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO3-HA) to a tumor site. Near-infrared (NIR) irradiated WO3-HA showed a rapid and substantial rise in photothermal heat to complete in vitro thermolysis of malignant MDAMB and A549 cancer cellsbut was found to be relatively less sensitive to normal MDCK cells. A long-term in vivo investigation of ~10 nm HA thickness on WO3 (WO3-HA) nanoparticles demonstrated efficient photo-thermal conversion with time-dependent tumor target accumulation. This long-termin vivo survival study ofWO3-HA showed promising biocompatibility, with a complete recovery from malignant tumor. Due to the importance of keeping simplicity in the design of therapeutic nanoparticles, we therefore expect that this facile scheme (HA-D) would contribute to the biocompatible development of versatile metallic nanoparticles for photothermal applications.
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.
authors.forename: Shazid Md
authors.initials: SM
authors.lastname: Sharker
authors.affiliation: Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea.
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Kim
authors.affiliation: School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Republic of Korea.
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: IT Convergence Material R&D Group, Korea Institute of Industrial Technology, Cheonan-si, Chungcheongnam-do 35-3, Republic of Korea.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Choi
authors.affiliation: IT Convergence Material R&D Group, Korea Institute of Industrial Technology, Cheonan-si, Chungcheongnam-do 35-3, Republic of Korea.
authors.forename: Gyojic
authors.initials: G
authors.lastname: Shin
authors.affiliation: IT Convergence Material R&D Group, Korea Institute of Industrial Technology, Cheonan-si, Chungcheongnam-do 35-3, Republic of Korea.
authors.forename: Sangkug
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Kosin University, Busan, Republic of Korea.
authors.forename: Kang Dae
authors.initials: KD
authors.lastname: Lee
authors.affiliation: School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Republic of Korea.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea. Electronic address: haeshin@kaist.ac.kr.
authors.forename: Haeshin
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea; Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea. Electronic address: parkchem@ut.ac.kr.
authors.forename: Sung Young
authors.initials: SY
authors.lastname: Park
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D004285:Dogs; D004298:Dopamine / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D008027:Light; D061985:Madin Darby Canine Kidney Cells; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000628:therapy*; D010087:Oxides / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D010789:Phototherapy; D014414:Tungsten / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D010087:Oxides; D006820:Hyaluronic Acid; C511604:tungsten oxide; D014414:Tungsten; D004298:Dopamine
keywords: Biocompatibility; Hyaluronic acid; Photothermal therapy; Target delivery; WO(3)