title: HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery.
abstract: A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy.
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea.
authors.forename: Hoyeon
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Korea University, Seoul, 136-701, Korea.
authors.forename: Soojin
authors.initials: S
authors.lastname: Uhm
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea.
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Shin
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea.
authors.forename: Hyun Mi
authors.initials: HM
authors.lastname: Jeon
authors.affiliation: Department of Chemistry, Korea University, Seoul, 136-701, Korea.
authors.forename: Sun
authors.initials: S
authors.lastname: Dongbang
authors.affiliation: Department of Chemistry, Korea University, Seoul, 136-701, Korea.
authors.forename: Hyo Sung
authors.initials: HS
authors.lastname: Jung
authors.affiliation: Omics System Research Team, Korea Basic Science Institute, 150 Bugahyeon-ro, Seodaemun-gu, Seoul, 120-140, Republic of Korea.
authors.forename: Yun-Cheol
authors.initials: YC
authors.lastname: Na
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea. kangch@khu.ac.kr.
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.affiliation: Department of Chemistry, Korea University, Seoul, 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000633:toxicity; D002166:Camptothecin / Q000737:chemistry* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D005690:Galactose / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D018613:Microscopy, Confocal; D013050:Spectrometry, Fluorescence
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D005690:Galactose; D002166:Camptothecin
keywords: anticancer drugs; camptothecin; cancer; drug delivery; galactose