title: A Voxel Based Morphometry Study of Brain Gray Matter Volumes in Juvenile Obsessive Compulsive Disorder.
abstract: BACKGROUND
  Adult patients with Obsessive Compulsive Disorder (OCD) have been shown to have gray matter (GM) volume differences from healthy controls in multiple regions - the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), medial frontal gyri (MFG), striatum, thalamus, and superior parietal lobule. However, there is paucity of data with regard to juvenile OCD. Hence, we examined GM volume differences between juvenile OCD patients and matched healthy controls using voxel based morphometry (VBM) with the above apriori regions of interest.
  
  
  METHODS
  Fifteen right handed juvenile patients with OCD and age- sex- handedness- matched healthy controls were recruited after administering the Mini International Neuropsychiatric Interview-KID and the Children's Yale-Brown Obsessive Compulsive Scale, and scanned using a 3 Tesla magnetic resonance imaging scanner. VBM methodology was followed.
  
  
  RESULTS
  In comparison with healthy controls, patients had significantly smaller GM volumes in left ACC. YBOCS total score (current) showed significant negative correlation with GM volumes in bilateral OFC, and left superior parietal lobule.
  
  
  CONCLUSIONS
  These findings while reiterating the important role of the orbito-fronto-striatal circuitry, also implicate in the parietal lobe - especially the superior parietal lobule as an important structure involved in the pathogenesis of OCD.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Rajan Nishanth
authors.initials: RN
authors.lastname: Jayarajan
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India ; Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Sri Mahavir
authors.initials: SM
authors.lastname: Agarwal
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Biju
authors.initials: B
authors.lastname: Viswanath
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India ; Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Kalmady
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India ; Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Ganesan
authors.initials: G
authors.lastname: Venkatasubramanian
authors.affiliation: Department of Child and Adolescent Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Shoba
authors.initials: S
authors.lastname: Srinath
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: C R
authors.initials: CR
authors.lastname: Chandrashekar
authors.affiliation: Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
authors.forename: Y C
authors.initials: YC
authors.lastname: Janardhan Reddy
keywords: childhood; gray matter; imaging; juvenile; neurobiology; obsessive compulsive disorder