title: Comparison of the postoperative analgesic effects of paracetamol-codeine phosphate and naproxen sodium-codeine phosphate for lumbar disk surgery.
abstract: The aim of this study was to compared the efficacy of paracetamol-codeine phosphate and naproxen sodium-codeine phosphate on postoperative pain and tramadol consumption during the first 24 hours after a lumbar disk surgery. After Ethics Committee approval and informed consent had been obtained, 64 patients were allocated into three groups. Patients received oral paracetamol-codeine (300 mg + 30 mg; Group P), naproxen sodium-codeine (550 mg + 30 mg; Group N), or placebo tablets (Group C) 30 minutes prior to induction of anesthesia. Patient-controlled analgesia was supplied postoperatively using tramadol. Pain intensity, tramadol consumption, and side effects were recorded every 1 hour, 2 hours, 6 hours, 12 hours, and 24 hours after surgery. Whole study period pain intensity (visual analogue scale scores) was lower in Group P (p = 0.007) and Group N (p = 0.001), compared with Group C, however, there was no statistically significant difference between Group P and Group N regarding pain intensity (p > 0.05). Tramadol consumption was lower in Group P and Group N, compared with Group C (p < 0.001), and in turn the lowest incidence of tramadol consumption was detected in Group P compared with Group N (p < 0.001) and Group C (p < 0.001). Side effects were similar between the groups. Preemptive administration of paracetamol-codeine and naproxen sodium-codeine combination significantly reduced tramadol consumption and provided more effective analgesia compared with placebo. The paracetamol-codeine combination was superior to naproxen sodium-codeine with regard to tramadol consumption.
authors.affiliation: Department of Anesthesiology, Diskapi Yildirim Beyazit Research and Training Hospital, Ministry of Health, Diskapi, Ankara, Turkey. Electronic address: reyhanp9@gmail.com.
authors.forename: Reyhan
authors.initials: R
authors.lastname: Polat
authors.affiliation: Department of Anesthesiology, Diskapi Yildirim Beyazit Research and Training Hospital, Ministry of Health, Diskapi, Ankara, Turkey.
authors.forename: Kevser
authors.initials: K
authors.lastname: Peker
authors.affiliation: Department of Statistics, Science Faculty, Bartin University, Bartin, Turkey.
authors.forename: Çiğdem Topçu
authors.initials: ÇT
authors.lastname: Gülöksüz
authors.affiliation: Department of Anesthesiology, Diskapi Yildirim Beyazit Research and Training Hospital, Ministry of Health, Diskapi, Ankara, Turkey.
authors.forename: Julide
authors.initials: J
authors.lastname: Ergil
authors.affiliation: Department of Anesthesiology, Diskapi Yildirim Beyazit Research and Training Hospital, Ministry of Health, Diskapi, Ankara, Turkey.
authors.forename: Taylan
authors.initials: T
authors.lastname: Akkaya
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D003061:Codeine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D011184:Postoperative Period; D014147:Tramadol / Q000627:therapeutic use
chemical_list: D000701:Analgesics, Opioid; D000082:Acetaminophen; D014147:Tramadol; D009288:Naproxen; D003061:Codeine
keywords: Analgesics; Lumbar disk surgery; Naproxen sodium; Nonnarcotic analgesics; Paracetamol