title: Total syntheses of natural products containing spirocarbocycles.
abstract: The structures of natural products from a variety of sources contain spirocycles, two rings that share a common atom. The spiro motif is finding increasing inclusion in drug candidates, and as a structural component in several promising classes of chiral ligands used in asymmetric synthesis. Total syntheses of products containing all-carbon spirocycles feature several common methods of ring closure which we examine in this review.
authors.affiliation: Department of Chemistry, Durham University, Stockton Road, Durham, DH1 3LE, UK. l.k.smith@dur.ac.uk.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Smith
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003500:Cyclization; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D013141:Spiro Compounds