title: The Centers for Disease Control and Prevention's public health response to monitoring Tdap safety in pregnant women in the United States.
abstract: In 2010, in response to a widespread pertussis outbreak and neonatal deaths, California became the first state to recommend routine administration of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine during pregnancy. In 2011, the Advisory Committee on Immunization Practices (ACIP) followed with a similar recommendation for Tdap vaccination during pregnancy for previously unvaccinated women. In 2012, this recommendation was expanded to include Tdap vaccination of every pregnant woman during each pregnancy. These recommendations were based on urgent public health needs and available evidence on the safety of other inactivated vaccines during pregnancy. However, there were limited data on the safety of Tdap during pregnancy. In response to the new ACIP recommendations, the Centers for Disease Control and Prevention (CDC) implemented ongoing collaborative studies to evaluate whether vaccination with Tdap during pregnancy adversely affects the health of mothers and their offspring and provide the committee with regular updates. The current commentary describes the public health actions taken by CDC to respond to the ACIP recommendation to study and monitor the safety of Tdap vaccines in pregnant women and describes the current state of knowledge on the safety of Tdap vaccines in pregnant women. Data from the various monitoring activities support the safety of Tdap use during pregnancy.
authors.affiliation: a Immunization Safety Office; Division of Healthcare Quality Promotion; Centers for Disease Control and Prevention ; Atlanta , GA USA.
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Moro
authors.affiliation: a Immunization Safety Office; Division of Healthcare Quality Promotion; Centers for Disease Control and Prevention ; Atlanta , GA USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: McNeil
authors.affiliation: a Immunization Safety Office; Division of Healthcare Quality Promotion; Centers for Disease Control and Prevention ; Atlanta , GA USA.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Sukumaran
authors.affiliation: a Immunization Safety Office; Division of Healthcare Quality Promotion; Centers for Disease Control and Prevention ; Atlanta , GA USA.
authors.forename: Karen R
authors.initials: KR
authors.lastname: Broder
mesh_terms: D002487:Centers for Disease Control and Prevention, U.S.; D004165:Diphtheria / Q000517:prevention & control*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D011247:Pregnancy; D037841:Pregnant People; D011634:Public Health; D012189:Retrospective Studies; D013742:Tetanus / Q000517:prevention & control*; D014481:United States; D014611:Vaccination; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines
keywords: Tdap; epidemiology; pregnancy; surveillance; vaccine safety