title: Assessing the Metabolic Diversity of Streptococcus from a Protein Domain Point of View.
abstract: Understanding the diversity and robustness of the metabolism of bacteria is fundamental for understanding how bacteria evolve and adapt to different environments. In this study, we characterised 121 Streptococcus strains and studied metabolic diversity from a protein domain perspective. Metabolic pathways were described in terms of the promiscuity of domains participating in metabolic pathways that were inferred to be functional. Promiscuity was defined by adapting existing measures based on domain abundance and versatility. The approach proved to be successful in capturing bacterial metabolic flexibility and species diversity, indicating that it can be described in terms of reuse and sharing functional domains in different proteins involved in metabolic activity. Additionally, we showed striking differences among metabolic organisation of the pathogenic serotype 2 Streptococcus suis and other strains.
authors.affiliation: Laboratory of Systems and Synthetic Biology, Wageningen University and Research Centre, Wageningen, The Netherlands.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Saccenti
authors.affiliation: Laboratory of Systems and Synthetic Biology, Wageningen University and Research Centre, Wageningen, The Netherlands.
authors.forename: David
authors.initials: D
authors.lastname: Nieuwenhuijse
authors.affiliation: Laboratory of Systems and Synthetic Biology, Wageningen University and Research Centre, Wageningen, The Netherlands.
authors.forename: Jasper J
authors.initials: JJ
authors.lastname: Koehorst
authors.affiliation: Laboratory of Systems and Synthetic Biology, Wageningen University and Research Centre, Wageningen, The Netherlands.
authors.forename: Vitor A P
authors.initials: VA
authors.lastname: Martins dos Santos
authors.affiliation: Laboratory of Systems and Synthetic Biology, Wageningen University and Research Centre, Wageningen, The Netherlands.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Schaap
mesh_terms: D000222:Adaptation, Physiological; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D013045:Species Specificity; D017011:Streptococcus suis / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins