title: Effects of CPAP on energy expenditure in obese obstructive sleep apnoea patients: A pilot study.
abstract: We conducted a placebo-controlled crossover pilot study investigating the effects of 2 mo of active and sham continuous positive airway pressure (CPAP) on energy expenditure (EE) via whole-room indirect calorimetry in three obese obstructive sleep apnoea (OSA) patients. Total 24-h (active: 2970 ± 254 kcal/d, sham: 2705 ± 217 kcal/d; p = 0.015) and mean sleeping (active: 1.60 ± 0.20 kcal/min; sham: 1.47 ± 0.17 kcal/min; p = 0.038) EE were significantly increased after active vs. sham CPAP. Findings suggest that CPAP may correct a hypoxia-related adaptive decrease in thermogenesis.
authors.affiliation: New York Obesity Research Center, Department of Medicine, Columbia University, New York, NY, United States. Electronic address: as4874@columbia.edu.
authors.forename: Ari
authors.initials: A
authors.lastname: Shechter
authors.affiliation: Institute of Human Nutrition, Columbia University, New York, NY, United States.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Pham
authors.affiliation: New York Obesity Research Center, Department of Medicine, Columbia University, New York, NY, United States.
authors.forename: Russell
authors.initials: R
authors.lastname: Rising
authors.affiliation: New York Obesity Research Center, Department of Medicine, Columbia University, New York, NY, United States; Institute of Human Nutrition, Columbia University, New York, NY, United States.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: St-Onge
mesh_terms: D015992:Body Mass Index; D002151:Calorimetry; D045422:Continuous Positive Airway Pressure; D018592:Cross-Over Studies; D004734:Energy Metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*; D010865:Pilot Projects; D020181:Sleep Apnea, Obstructive / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D022722:Thermogenesis
keywords: CPAP; Energy expenditure; Indirect calorimetry; Obesity; Sleep apnoea