title: [Treatment of Epidermal Growth Factor Receptor Inhibitors Associated Adverse Skin Reactions by Zhiyang Pingfu Liquid: a Clinical Study].
abstract: OBJECTIVE
  To study the curative effect of Zhiyang Pingfu Liquid (ZPL) in treating epidermal growth factor receptor inhibitors (EGFRIs) associated adverse reactions of the skin.
  
  
  METHODS
  All 54 patients with pathologically confirmed malignant tumor had EGFRIs induced adverse reactions of the skin to various degrees. ZPL was externally applied for them all, once or twice per day, 14 days consisting of one therapeutic course. Changes of adverse skin reactions, time for symptoms relief, adverse skin reaction types suitable for ZPL were observed before and after treatment.
  
  
  RESULTS
  EGFRIs associated skin adverse reactions were improved to various degrees after they used ZPL. The shortest symptoms relief time was 1 day while the longest was 12 days, with an average of 6.93 days and the median time 7 days. Compared with before treatment, itching, rash/scaling, acne/acneform eruptions were obviously improved (P < 0.05).
  
  
  CONCLUSIONS
  ZPL could alleviate EGFRls associated adverse skin reactions, especially showed better effect on itching, rash/scaling, acne/acneform eruptions.
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Zou
authors.forename: Hui-juan
authors.initials: HJ
authors.lastname: Cui
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Bai
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Huang-ying
authors.initials: HY
authors.lastname: Tan
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Hai
authors.initials: H
authors.lastname: Ju
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D035843:Biomedical Research; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D005076:Exanthema / Q000139:chemically induced; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D011537:Pruritus; D012867:Skin / Q000187:drug effects; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D066246:ErbB Receptors