title: The B-cell antigen receptor integrates adaptive and innate immune signals.
abstract: B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.
authors.affiliation: Immune Disease Institute, Harvard Medical School, Boston, MA 02115; Klaus.Rajewsky@mdc-berlin.de kevin.otipoby@biogen.com.
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Otipoby
authors.affiliation: Institute for Genetics, University of Cologne, 50674 Cologne, Germany;
authors.forename: Ari
authors.initials: A
authors.lastname: Waisman
authors.affiliation: Immune Disease Institute, Harvard Medical School, Boston, MA 02115; Laboratory for Immune Regulation and Cancer, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Derudder
authors.affiliation: Immune Disease Institute, Harvard Medical School, Boston, MA 02115;
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Srinivasan
authors.affiliation: Laboratory for Immune Regulation and Cancer, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany.
authors.forename: Andrew
authors.initials: A
authors.lastname: Franklin
authors.affiliation: Immune Disease Institute, Harvard Medical School, Boston, MA 02115; Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Laboratory for Immune Regulation and Cancer, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany Klaus.Rajewsky@mdc-berlin.de kevin.otipoby@biogen.com.
authors.forename: Klaus
authors.initials: K
authors.lastname: Rajewsky
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D049109:Cell Proliferation / Q000502:physiology*; D002470:Cell Survival / Q000276:immunology; D002478:Cells, Cultured; D017931:DNA Primers / Q000235:genetics; D024202:Electrophoretic Mobility Shift Assay; D005434:Flow Cytometry; D007113:Immunity, Innate / Q000276:immunology*; D015151:Immunoblotting; D051379:Mice; D018448:Models, Immunological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D017931:DNA Primers; D011947:Receptors, Antigen, B-Cell; D019869:Phosphatidylinositol 3-Kinases
keywords: B-cell proliferation; BCR; Foxo1; GSK3β; PI-3K