title: The Quest for Nonthrombotic Surface Modifications to Achieve Hemocompatibility of Implantable Devices.
abstract: The use of blood-contacting implantable devices is limited by surface-induced thrombosis, which has led to the development of thromboresistant surfaces. Multidisciplinary efforts have promoted the development of surface modifications to minimize thrombosis by targeting surface-induced coagulation. To this date, no material has been identified that remains irrevocably hemocompatible with time but many options are now available with their own limitations. Essential to this review is the understanding of some of the challenges in this field and newer opportunities for hemocompatibility research. This report will also briefly review many of the achievements in the development of hemocompatible biomaterial coating, including surface modifications against protein adsorption and platelet adhesion, biomimetism, and endothelialization.
authors.affiliation: From the Section of Cardiac Surgery, Center for Advanced Heart Failure and Transplantation, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Lise Nadine
authors.initials: LN
authors.lastname: Tchouta
authors.forename: Pramod Narayan
authors.initials: PN
authors.lastname: Bonde
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use; D006801:Humans; D008422:Materials Testing; D019736:Prostheses and Implants / Q000009:adverse effects*; D013499:Surface Properties; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D020099:Coated Materials, Biocompatible