title: Developing new extension of GafChromic RTQA2 film to patient quality assurance field using a plan-based calibration method.
abstract: GafChromic RTQA2 film is a type of radiochromic film designed for light field and radiation field alignment. The aim of this study is to extend the application of RTQA2 film to the measurement of patient specific quality assurance (QA) fields as a 2D relative dosimeter.Pre-irradiated and post-irradiated RTQA2 films were scanned in reflection mode using a flatbed scanner. A plan-based calibration (PBC) method utilized the mapping information of the calculated dose image and film grayscale image to create a dose versus pixel value calibration model. This model was used to calibrate the film grayscale image to the film relative dose image. The dose agreement between calculated and film dose images were analyzed by gamma analysis. To evaluate the feasibility of this method, eight clinically approved RapidArc cases (one abdomen cancer and seven head-and-neck cancer patients) were tested using this method. Moreover, three MLC gap errors and two MLC transmission errors were introduced to eight Rapidarc cases respectively to test the robustness of this method.The PBC method could overcome the film lot and post-exposure time variations of RTQA2 film to get a good 2D relative dose calibration result. The mean gamma passing rate of eight patients was 97.90%  ±  1.7%, which showed good dose consistency between calculated and film dose images. In the error test, the PBC method could over-calibrate the film, which means some dose error in the film would be falsely corrected to keep the dose in film consistent with the dose in the calculated dose image. This would then lead to a false negative result in the gamma analysis. In these cases, the derivative curve of the dose calibration curve would be non-monotonic which would expose the dose abnormality.By using the PBC method, we extended the application of more economical RTQA2 film to patient specific QA. The robustness of the PBC method has been improved by analyzing the monotonicity of the derivative of the calibration curve.
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Jiayuan
authors.initials: J
authors.lastname: Peng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jiazhou
authors.initials: J
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Xie
authors.forename: Junchao
authors.initials: J
authors.lastname: Chen
authors.forename: Weigang
authors.initials: W
authors.lastname: Hu
mesh_terms: D000008:Abdominal Neoplasms / Q000532:radiotherapy*; D002138:Calibration; D005373:Film Dosimetry / Q000295:instrumentation* / Q000592:standards*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008962:Models, Theoretical; D011785:Quality Assurance, Health Care; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal