title: Respiratory Syncytial Virus Preterm (32-36 Completed Weeks of Gestation) Risk Estimation Measure for RSV Hospitalization in Ireland: A Prospective Study.
abstract: BACKGROUND
  In several countries, respiratory syncytial virus prophylaxis is offered to late preterm infants who are at escalated risk of respiratory syncytial virus hospitalization (RSVH). However, targeted prophylaxis should be informed by country-specific data. This study, which uniquely includes 36 weeks of gestational age (GA) infants, aims to establish the risk factors for RSVH in 32-36 weeks of GA infants in Ireland.
  
  
  METHODS
  A prospective observational study at 13 hospitals of laboratory-confirmed RSVH in nonprophylaxed 32-36 weeks of GA infants was conducted from July 2011 to February 2014. Baseline and first-year clinical data were analyzed by using SPSS software Version 22 (IBM Corp, Armonk, NY). Significant (P < 0.05) variables were entered into multiple logistic regression to determine the independent risk factors for RSVH.
  
  
  RESULTS
  Sixty-three percent of eligible infants (1825 of 2877) were recruited. The RSVH rate was 3.6% (65 of 1807 analyzed infant records). There was no RSV-attributable mortality. Twelve infants required intensive care. Of the 15 variables correlating to RSVH, 5 independent risk factors were identified: older siblings [odds ratio (OR): 3.8; 95% confidence interval (CI): 1.97-7.41], being Caucasian (OR: 2.3; 95% CI: 1.04-5.29), neonatal respiratory morbidity (OR: 2.2; 95% CI: 1.28-3.94); birth July 15 to December 15 (OR: 2.1; 95% CI: 1.09-3.92) and family history of asthma (OR: 1.9; 95% CI: 1.01-3.39). Birth from 36 weeks to 36 + 6 days mitigated RSVH risk (relative risk: 0.58; 95% CI: 0.34-0.99); however, risk factors were similar to the 32-35 weeks of GA cohort.
  
  
  CONCLUSIONS
  Neonatal respiratory morbidity or being Caucasian were the population-specific independent risk factors for RSVH in 32-36 weeks of GA in Ireland, whereas the other identified independent risk factors mirrored those established in previous studies.
authors.affiliation: From the *Department of Paediatrics and Newborn Medicine, Coombe Women and Infants University Hospital, Dublin; †Department of Paediatrics, Trinity College Dublin, Dublin; ‡National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Crumlin, Dublin; §Department of Pediatrics, Cavan General Hospital, Cavan, Dublin; ¶Children's University Hospital, Dublin; ‖Department of Paediatrics, Cork University Maternity Hospital, Wilton, Cork; **Department of Paediatrics, AMNCH Tallaght Hospital, Dublin; ††Department of Paediatrics, Rotunda Hospital, Dublin; ‡‡Department of Pediatrics, Midlands Regional Hospital, Mullingar; §§Department of Pediatrics, Midlands Regional Hospital, Portlaoise; ¶¶Department of Pediatrics, Mt. Carmel Hospital, Dublin; ‖‖Department of Pediatrics, National Maternity Hospital, Dublin; ***Department of Pediatrics, Our Lady of Lourdes Hospital, Drogheda, Co Louth; †††Department of Pediatrics, South Tipperary General Hospital, Clonmel; ‡‡‡Department of Pediatrics, St. Luke's Hospital, Kilkenny; §§§Department of Pediatrics, Waterford Regional Hospital, Waterford; ¶¶¶Department of Pediatrics, Wexford General Hospital, Wexford, Ireland; ‖‖‖Division of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, The Netherlands; and ****Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Margaret
authors.initials: M
authors.lastname: Sheridan-Pereira
authors.forename: Joan
authors.initials: J
authors.lastname: Murphy
authors.forename: Julie
authors.initials: J
authors.lastname: Sloan
authors.forename: Gloria
authors.initials: G
authors.lastname: Crispino
authors.forename: Anne
authors.initials: A
authors.lastname: Leahy
authors.forename: J David
authors.initials: JD
authors.lastname: Corcoran
authors.forename: Eugene
authors.initials: E
authors.lastname: Dempsey
authors.forename: Basil
authors.initials: B
authors.lastname: Elnazir
authors.forename: Patrick
authors.initials: P
authors.lastname: Gavin
authors.forename: Farhana
authors.initials: F
authors.lastname: Sharif
authors.forename: Rizwan
authors.initials: R
authors.lastname: Gul
authors.forename: Salius
authors.initials: S
authors.lastname: Satas
authors.forename: John
authors.initials: J
authors.lastname: Murphy
authors.forename: Siobhan
authors.initials: S
authors.lastname: Gormally
authors.forename: Issam
authors.initials: I
authors.lastname: Shanaa
authors.forename: David
authors.initials: D
authors.lastname: Waldron
authors.forename: Paul
authors.initials: P
authors.lastname: Mc Mahon
authors.forename: John
authors.initials: J
authors.lastname: Carson
authors.forename: Maarten
authors.initials: M
authors.lastname: Blanken
authors.forename: Louis
authors.initials: L
authors.lastname: Bont
authors.forename: Bosco
authors.initials: B
authors.lastname: Paes
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007494:Ireland / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human; D018570:Risk Assessment; D012307:Risk Factors