title: [Methods of acute pancreatitis prevention after endoscopic transpapillary interventions].
abstract: OBJECTIVE
  To optimize preventive methods of acute postoperative pancreatitis in endoscopic transpapillary interventions.
  
  
  METHODS
  It is performed parallel unblinded randomized investigation. The first group included 98 patients who underwent endoscopic transpapillary interventions and thoracic epidural analgesia (TEA). The second group consisted of 97 patients in whom opiate analgesic intramuscularly and indomethacin per rectum were applied.
  
  
  RESULTS
  Study revealed that acute pancreatitis has been diagnosed significantly more seldom in patients after TEA than in the second group (OR 0.22, CI 95%, 0.06-0.83). Thus in TEA-group pancreatitis was verified in 3.1% (3 of 98 patients), in the second group - in 12.4% (12 of 97 patients). Incidence of pancreatitis decreased from 23.3% (10 of 43) to 4.3% (2 of 46) among high risk patients (OR 0.15, 95% CI 0.03-0.75).
  
  
  CONCLUSIONS
  TEA is effective and justified preventive method in patients with high risk of postoperative pancreatitis. In low risk patients use of indomethacin per rectum is preferred compared with TEA due to its invasiveness.
authors.affiliation: Chair of Surgery with the course of endoscopic surgery of the Volgograd State Medical University Ministry of Health of the Russian Federation.
authors.forename: A G
authors.initials: AG
authors.lastname: Beburishvili
authors.affiliation: Chair of Surgery with the course of endoscopic surgery of the Volgograd State Medical University Ministry of Health of the Russian Federation; Hospital #1 of the Volgograd State Medical University Ministry of Health of the Russian Federation.
authors.forename: E N
authors.initials: EN
authors.lastname: Ziubina
authors.affiliation: Hospital #1 of the Volgograd State Medical University Ministry of Health of the Russian Federation.
authors.forename: M I
authors.initials: MI
authors.lastname: Turovets
authors.affiliation: Chair of Surgery with the course of endoscopic surgery of the Volgograd State Medical University Ministry of Health of the Russian Federation; The Chair Anaesthesiology and reanimatology of the Volgograd State Medical University Ministry of Health of the Russian Federation.
authors.forename: V V
authors.initials: VV
authors.lastname: Mandrikov
mesh_terms: D000285:Administration, Rectal; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015360:Analgesia, Epidural / Q000379:methods*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D007213:Indomethacin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin