title: Bridging the Translation Gap: From Dementia Risk Assessment to Advice on Risk Reduction.
abstract: Dementia risk reduction is a global health and fiscal priority given the current lack of effective treatments and the projected increased number of dementia cases due to population ageing. There are often gaps among academic research, clinical practice, and public policy. We present information on the evidence for dementia risk reduction and evaluate the progress required to formulate this evidence into clinical practice guidelines. This narrative review provides capsule summaries of current evidence for 25 risk and protective factors associated with AD and dementia according to domains including biomarkers, demographic, lifestyle, medical, and environment. We identify the factors for which evidence is strong and thereby especially useful for risk assessment with the goal of personalising recommendations for risk reduction. We also note gaps in knowledge, and discuss how the field may progress towards clinical practice guidelines for dementia risk reduction.
authors.affiliation: Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, Australian National University.
authors.forename: Kaarin J
authors.initials: KJ
authors.lastname: Anstey
authors.affiliation: Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, Australian National University.
authors.forename: Ranmalee
authors.initials: R
authors.lastname: Eramudugolla
authors.affiliation: Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, Australian National University.
authors.forename: Diane E
authors.initials: DE
authors.lastname: Hosking
authors.affiliation: Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, University of Melbourne ; School of Psychiatry and Clinical Neurosciences & WA Centre for Health and Ageing, University of Western Australia.
authors.forename: Nicola T
authors.initials: NT
authors.lastname: Lautenschlager
authors.affiliation: Department of Psychology, University of Alberta, Canada.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Dixon
keywords: Alzheimer disease; Risk factor; cognitive decline; prevention; risk assessment