title: Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1.
abstract: During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trials as anticancer agent. Here, we show that AS1411 exhibits extremely potent antiviral activity and is therefore an attractive new lead as anti-HIV agent.
authors.affiliation: Laboratoire MFP, CNRS UMR-5234, Université de Bordeaux, FR Transbiomed, 146 Rue Léo Saignat, 33076 Bordeaux, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Métifiot
authors.affiliation: INSERM U869, IECB, ARNA Laboratory, Université de Bordeaux, 2 Rue Robert Escarpit, 33600 Pessac, France.
authors.forename: Samir
authors.initials: S
authors.lastname: Amrane
authors.affiliation: INSERM U869, IECB, ARNA Laboratory, Université de Bordeaux, 2 Rue Robert Escarpit, 33600 Pessac, France. Electronic address: jean-louis.mergny@inserm.fr.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
authors.affiliation: Laboratoire MFP, CNRS UMR-5234, Université de Bordeaux, FR Transbiomed, 146 Rue Léo Saignat, 33076 Bordeaux, France. Electronic address: marie-aline.andreola@u-bordeaux.fr.
authors.forename: Marie-Line
authors.initials: ML
authors.lastname: Andreola
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D052157:Aptamers, Nucleotide; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*
chemical_list: C513936:AGRO 100; D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D052157:Aptamers, Nucleotide; D009838:Oligodeoxyribonucleotides
keywords: Anticancer; Antiviral; G-quadruplexes; Nucleolin; Zintevir