title: Solid Variant of Adenoid Cystic Carcinoma of the Breast: A Case Series With Proposal of a New Grading System.
abstract: Adenoid cystic carcinoma (ACC) of the breast is a low-grade malignancy "triple negative" breast tumor. ACC of the breast can present a great variety of morphological features having a prognostic impact. Recently, cases of ACC having solid-basaloid features (SBACC) have been described. In the present study, 6 cases of SBACC have been reported. All the cases affected female patients aged 47 to 69 years (mean = 54 years). Two patients had metastases to the axillary lymph nodes, and 2 patients experienced local recurrences. No deaths due to the tumor were observed. A review of the literature on breast SBACC showed that local recurrences and lymph node metastases are more frequent than in the ACC conventional type; nevertheless, no deaths due to the tumor are registered at the moment. On the contrary, cases of ACC with features of malignant transformation are on record. Therefore, a new grading system on breast ACC is proposed.
authors.affiliation: Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences of the University of Bologna, Bellaria Hospital, Bologna, Italy Mariapia.foschini@unibo.it.
authors.forename: Maria P
authors.initials: MP
authors.lastname: Foschini
authors.affiliation: Operative Unit of Anatomic Pathology, S. Giacomo Hospital, Castelfranco Veneto, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rizzo
authors.affiliation: Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences of the University of Bologna, Bellaria Hospital, Bologna, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: De Leo
authors.affiliation: Operative Unit of Anatomic Pathology, Treviso General Hospital, Treviso, Italy.
authors.forename: Licia
authors.initials: L
authors.lastname: Laurino
authors.affiliation: Operative Unit of Anatomic Pathology, Department of General Pathology, ASL4 Chiavarese, Sestri Levante, Genoa.
authors.forename: Maria
authors.initials: M
authors.lastname: Sironi
authors.affiliation: Operative Unit of Anatomic Pathology, ASL5 Arzignano (VI) ULSS5-Ovest Vicentino.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Rucco
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology
keywords: adenoid cystic carcinoma; breast; grading; solid basaloid adenoid cystic carcinoma