title: Repurposing some older drugs that cross the blood-brain barrier and have potential anticancer activity to provide new treatment options for glioblastoma.
abstract: Glioblastoma is a brain neoplasm with limited 5-year survival rates. Developments of new treatment regimens that improve patient survival in patients with glioblastoma are needed. It is likely that a number of existing drugs used in other conditions have potential anticancer effects that offer significant survival benefit to glioblastoma patients. Identification of such drugs could provide a novel treatment paradigm.
authors.affiliation: School of Medicine, Flinders University, Bedford Park, SA, Australia.
authors.forename: Dayle
authors.initials: D
authors.lastname: Rundle-Thiele
authors.affiliation: Future Industries Institute, Research and Innovation Portfolio, University of South Australia, Adelaide, SA, Australia.
authors.forename: Richard
authors.initials: R
authors.lastname: Head
authors.affiliation: CSIRO, Human and Nutrition Flagship, Adelaide, SA, Australia.
authors.forename: Leah
authors.initials: L
authors.lastname: Cosgrove
authors.affiliation: School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Martin
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000378:metabolism; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D058492:Drug Repositioning; D005909:Glioblastoma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans
chemical_list: D000970:Antineoplastic Agents
keywords: antidepressants; antiepileptic drugs; antihypertensive; beta-blockers; glioblastoma; statins