title: Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases.
abstract: Previous studies have identified the immunological functions of transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) in various adaptive immune cell types such as T and B lymphocytes. More recently, it has been shown that Blimp-1 extends its functional roles to dendritic cells (DCs) and macrophages, two cell types belonging to the innate immune system. The protein acts as a direct and indirect regulator of target genes by recruiting chromatin modification factors and by regulating microRNA expression, respectively. In DCs, Blimp-1 has been identified as one of the components involved in antigen presentation. Genome-wide association studies identified polymorphisms associated with multiple autoimmune diseases such as system lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease in PRDM1, the gene encoding Blimp-1 protein. In this review, we will discuss the immune regulatory functions of Blimp-1 in DCs with a main focus on the tolerogenic mechanisms of Blimp-1 required to protect against the development of autoimmune diseases.
authors.affiliation: Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, 11030, USA. sjkim@nshs.edu.|Department of Molecular Medicine, Hofstra-North Shore LIJ School of Medicine, Hempstead, NY, USA. sjkim@nshs.edu.
authors.forename: Sun Jung
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D001327:Autoimmune Diseases / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D012097:Repressor Proteins; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1
keywords: Antigen presentation; Blimp-1; Dendritic cells; SLE