title: Presence of the HLADR13 allele among Mexican Mestizos suggests a protective factor against relapsing-remitting multiple sclerosis (RRMS).
abstract: OBJECTIVE
  Multiple sclerosis (MS) is a chronic demyelinating disease that affects the central nervous system. Researchers have looked for an association between relapsing-remitting MS (RRMS) and human leukocyte antigen (HLA) as risk or protective factor associated to ethnicity, which may add a partial explanation to disease heterogeneity and geographical variations. We described the frequency of the HLA-DR alleles in Mexican Mestizo (RRMS) patients.
  
  
  METHODS
  We included 143 RRMS patients and 377 healthy controls, both Mexican Mestizos. Previous signing informed consent, we record demographic and clinical characteristics of the participants. Genetic profile was made, and HLA frequencies in both groups were compared.
  
  
  RESULTS
  RRMS patients were 39.8% male and 60.2% female, mean age was 35 years. While, controls were 48%male and 52% women, mean age was 38 years. The most frequent allele found in subjects with RRMS was DR 15 (p=0.006, OR=2.2, 95% CI: 1.3-3.6). DR 13 allele was more frequent among healthy subjects than RRMS patients (p=0.050) with a protective OR 2.6, (95% CI: 1.3-5.2, p=0.050).
  
  
  CONCLUSIONS
  In our study we found HLA DR 13 was more frequent in healthy controls than in RRMS patients, suggesting a protective factor among Mexican Mestizo population.
authors.affiliation: Laboratory of Clinical Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur # 3877, CP 14269 Mexico City, Mexico.
authors.forename: José
authors.initials: J
authors.lastname: Flores
authors.affiliation: Genetics and Neuroimmunology Laboratory, National Institute of Medical Sciences and Nutrition, Periférico Sur # 4809, CP 14610 Mexico City, Mexico. Electronic address: julgrate@yahoo.com.
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.affiliation: Genetics Laboratory, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur # 3877, CP 14269 Mexico City, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Alonso
authors.affiliation: Laboratory of Clinical Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur # 3877, CP 14269 Mexico City, Mexico.
authors.forename: Yamel
authors.initials: Y
authors.lastname: Rito
authors.affiliation: Genetics and Neuroimmunology Laboratory, National Institute of Medical Sciences and Nutrition, Periférico Sur # 4809, CP 14610 Mexico City, Mexico.
authors.forename: Esteban
authors.initials: E
authors.lastname: Ortega-Hernández
authors.affiliation: Genetics and Neuroimmunology Laboratory, National Institute of Medical Sciences and Nutrition, Periférico Sur # 4809, CP 14610 Mexico City, Mexico.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mena-Hernández
authors.affiliation: Laboratory of Clinical Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur # 3877, CP 14269 Mexico City, Mexico. Electronic address: coronav@servidorunam.mx.
authors.forename: Teresa
authors.initials: T
authors.lastname: Corona
mesh_terms: D000328:Adult; D000483:Alleles; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059810:HLA-DR Serological Subtypes / Q000235:genetics; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000208:ethnology / Q000235:genetics*; D065840:Protective Factors
chemical_list: D059810:HLA-DR Serological Subtypes; C097337:HLA-DR13 antigen
keywords: Alleles; HLA-DR; Mexican Mestizos; Multiple sclerosis relapsing-remitting; Protective factors