title: An atypical case of chronic diarrhoea: olmesartan-induced sprue-like enteropathy.
abstract: Olmesartan use has been associated with chronic diarrhoea and weight loss due to severe sprue-like enteropathy, yet this is still not well known among clinicians. We present the unique case of an 84-year-old Filipino woman diagnosed with olmesartan-induced sprue-like enteropathy after an extensive work up for chronic diarrhoea, and without improvement despite multiple empiric treatments for nearly 15 months. Withdrawal of olmesartan resulted in clinical and histological improvement. This case provides further evidence for olmesartan-induced sprue-like enteropathy, and emphasises the importance of its awareness and recognition among gastroenterologists and primary care physicians alike.
authors.affiliation: Department of Internal Medicine, University of Florida, Gainesville, Florida, USA.
authors.forename: Dhaval K
authors.initials: DK
authors.lastname: Naik
authors.affiliation: Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Martelli
authors.affiliation: Department of Pathology, University of Florida, Gainesville, Florida, USA.
authors.forename: David Hernandez
authors.initials: DH
authors.lastname: Gonzalo
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, Gainesville, Florida, USA.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, Gainesville, Florida, USA.
authors.forename: Davinderbir
authors.initials: D
authors.lastname: Pannu
mesh_terms: D000369:Aged, 80 and over; D001284:Atrophy; D002446:Celiac Disease / Q000473:pathology; D003967:Diarrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000473:pathology; D007422:Intestines / Q000473:pathology*; D000068557:Olmesartan Medoxomil / Q000009:adverse effects*; D013777:Tetrazoles / Q000009:adverse effects*
chemical_list: D007093:Imidazoles; D013777:Tetrazoles; D000068557:Olmesartan Medoxomil; C437965:olmesartan