title: Presence of anti-HBc is associated to high rates of HBV resolved infection and low threshold for Occult HBV Infection in HIV patients with negative HBsAg in Chile.
abstract: HBV-HIV coinfection is prevalent. Frequently, anti-HBc is the only serological marker of HBV, which can be indicative of HBV resolved infection, when found together with anti-HBs reactivity; or present as "isolated anti-HBc," related to HBV occult infection with presence of detectable DNA HBV, more prevalent in HIV-positive individuals. Regional data about this condition are scarce. Anti-HBc rapid test has been used as screening, but its performance has not been described in HIV-positive patients. The aim of this study was determine prevalence of anti-HBc in HIV-positive patients, serological pattern of HBV resolved infection and isolated anti-HBc, evaluating presence of HBV occult infection. Assess anti-HBc rapid test compared to ECLIA. Methods included measurement of anti-HBc and anti-HBs in HIV-positive patients with negative HBsAg. Serum HBV DNA quantification and HBV booster vaccination to "isolated anti-HBc" individuals. Detection of anti-HBc by rapid test and ECLIA. In 192 patients, prevalence of anti-HBc was 42.7% (82/192); associated to male gender, drug use, men-sex-men, positive-VDRL, and longer time HIV diagnosis. 34.4% (66/192) had presence of anti-HBs, mean titers of 637 ui/ml. Isolated anti-HBc in 8.3% (16/192), associated to detectable HIV viral load and no-use of HAART; in them, HBV DNA was undetectable, and 60% responded to HBV vaccination booster. Anti-HBc rapid test showed low sensibility (32.9%) compared to ECLIA. These results show that prevalence of anti-HBc in HIV-positive individuals is high, in most cases accompanied with anti-HBs as HBV resolved infection. Low prevalence of "isolated anti-HBc," with undetectable HBV DNA, and most had anamnestic response to HBV vaccination; suggest low possibility of occult HBV infection. Anti-HBc rapid test cannot be recommended as screening method for anti-HBc.
authors.affiliation: Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.|Servicio de Medicina Interna, Hospital Naval Almirante Nef, Viña del Mar, Chile.
authors.forename: Jose Ignacio
authors.initials: JI
authors.lastname: Vargas
authors.affiliation: Servicio de Medicina Interna, Hospital Naval Almirante Nef, Viña del Mar, Chile.|Escuela de Medicina, Universidad de Valparaíso, Valparaíso, Chile.
authors.forename: Daniela
authors.initials: D
authors.lastname: Jensen
authors.affiliation: Unidad de Hepatología, Hospital Gustavo Fricke, Viña del Mar, Chile.|Departamento de Infectología, Hospital Gustavo Fricke, Viña del Mar, Chile.
authors.forename: Valeska
authors.initials: V
authors.lastname: Sarmiento
authors.affiliation: Escuela de Medicina, Universidad de Valparaíso, Valparaíso, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Peirano
authors.affiliation: Escuela de Medicina, Universidad Andrés Bello, Viña del Mar, Chile.
authors.forename: Pedro
authors.initials: P
authors.lastname: Acuña
authors.affiliation: Escuela de Medicina, Universidad Del Desarrollo, Santiago, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Fuster
authors.affiliation: Laboratorio Clínico ACLIN, Viña del Mar, Chile.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Soto
authors.affiliation: Departamento de Infectología, Hospital Gustavo Fricke, Viña del Mar, Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Ahumada
authors.affiliation: Departamento de Infectología, Hospital Gustavo Fricke, Viña del Mar, Chile.
authors.forename: Marco
authors.initials: M
authors.lastname: Huilcaman
authors.affiliation: Departamento de Infectología, Hospital Gustavo Fricke, Viña del Mar, Chile.
authors.forename: Mario
authors.initials: M
authors.lastname: Bruna
authors.affiliation: Escuela de Medicina, Universidad de Valparaíso, Valparaíso, Chile.|Departamento de Infectología, Hospital Gustavo Fricke, Viña del Mar, Chile.
authors.forename: Werner
authors.initials: W
authors.lastname: Jensen
authors.affiliation: Unidad de Hepatología, Hospital Gustavo Fricke, Viña del Mar, Chile.
authors.forename: Francisco
authors.initials: F
authors.lastname: Fuster
mesh_terms: D000328:Adult; D002353:Carrier State / Q000821:virology; D002677:Chile / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology* / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens
keywords: HBV occult infection (OBI); anti-HBc rapid test; hepatitis B virus; human immunodeficiency virus; isolated anti-HBc