title: Expression of S100 Protein in CD4-positive T-cell Lymphomas Is Often Associated With T-cell Prolymphocytic Leukemia.
abstract: S100 T-cell lymphomas are infrequent, and except 1 all have been CD4 negative. On the basis of an index case of CD4 S100 T-cell prolymphocytic leukemia (T-PLL), we studied S100 protein expression in 19 additional T-PLLs and 56 other T-cell lymphomas that are usually CD4, including 15 angioimmunoblastic T-cell lymphomas, 24 anaplastic large cell lymphomas (16 ALK and 8 ALK), 7 mycosis fungoides/Sézary syndrome, and 10 peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS). Two additional S100 CD4 PTCL, NOS cases were also reviewed. Thirty percent (6/20) of T-PLLs were S100 compared with 0/56 other T-cell lymphomas with previously unstudied S100 reactivity (40 CD4, 2 CD8, 11 CD4/CD8, 3 unknown) (P=0.0007). There were no significant differences between the S100 and S100 T-PLLs with regard to the male:female ratio (2:1 vs. 1:1), age (71.6±7.7 vs. 65.4±9.3), peripheral blood lymphocyte count (67.2±116.6 vs. 101.1±159.7×10/L), or median survival (463 vs. 578 d, where known). The 2 S100 PTCL, NOS cases occurred in a 7-year-old boy and a 45-year-old woman. Both had involvement of the bone marrow and peripheral blood but were morphologically unlike T-PLL and lacked TCL1 gene rearrangement. These results demonstrate that S100 T-cell lymphomas include a subset that are CD4 and most often, but not exclusively, are T-PLL. Although having diagnostic implications, there were no documented clinical differences between the S100 and S100 T-PLLs.
authors.affiliation: *Department of Pathology, Division of Hematopathology, University of Pittsburgh School of Medicine, Pittsburgh, PA ¶Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA §Department of Pathology, Penn State College of Medicine, Milton S. Hershey Medical Center, Hershey, PA ‡Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA ∥Department of Pathology, City of Hope Medical Center, Duarte, CA Departments of †Pathology #Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Aggarwal
authors.forename: Tawatchai
authors.initials: T
authors.lastname: Pongpruttipan
authors.forename: Snehal
authors.initials: S
authors.lastname: Patel
authors.forename: Michael G
authors.initials: MG
authors.lastname: Bayerl
authors.forename: Serhan
authors.initials: S
authors.lastname: Alkan
authors.forename: Bharat
authors.initials: B
authors.lastname: Nathwani
authors.forename: Urvashi
authors.initials: U
authors.lastname: Surti
authors.forename: Sumire
authors.initials: S
authors.lastname: Kitahara
authors.forename: Yingyong
authors.initials: Y
authors.lastname: Chinthammitr
authors.forename: Steven H
authors.initials: SH
authors.lastname: Swerdlow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001706:Biopsy; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry* / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D053208:Kaplan-Meier Estimate; D015461:Leukemia, Prolymphocytic, T-Cell / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000737:chemistry* / Q000235:genetics / Q000276:immunology / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D009418:S100 Proteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins