title: Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men.
abstract: BACKGROUND
  Genome-wide association studies have been used extensively to identify genetic variants linked to metabolic syndrome (MetS), but most of them have been conducted in non-Asian populations. This study aimed to evaluate the association between MetS and previously studied single nucleotide polymorphisms (SNPs), and their interaction with health-related behavior in Korean men.
  
  
  METHODS
  Seventeen SNPs were genotyped and their association with MetS and its components was tested in 1193 men who enrolled in the study at Seoul National University Hospital.
  
  
  RESULTS
  We found that rs662799 near APOA5 and rs769450 in APOE had significant association with MetS and its components. The SNP rs662799 was associated with increased risk of MetS, elevated triglyceride (TG) and low levels of high-density lipoprotein, while rs769450 was associated with a decreased risk of TG. The SNPs showed interactions between alcohol drinking and physical activity, and TG levels in Korean men.
  
  
  CONCLUSIONS
  We have identified the genetic association and environmental interaction for MetS in Korean men. These results suggest that a strategy of prevention and treatment should be tailored to personal genotype and the population.
authors.affiliation: Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. mdsky75@gmail.com.|Health Promotion Center, Seoul National University Hospital, Seoul, Republic of Korea. mdsky75@gmail.com.
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Son
authors.affiliation: Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea. son7292@snu.ac.kr.
authors.forename: Ho-Young
authors.initials: HY
authors.lastname: Son
authors.affiliation: Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea. moverm0210@gmail.com.
authors.forename: Jeesoo
authors.initials: J
authors.lastname: Chae
authors.affiliation: Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea. jinhada@naver.com.
authors.forename: Jinha
authors.initials: J
authors.lastname: Hwang
authors.affiliation: Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea. ja_sesong_ng@hotmail.com.
authors.forename: SeSong
authors.initials: S
authors.lastname: Jang
authors.affiliation: Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. jaemoon2@gmail.com.|Health Promotion Center, Seoul National University Hospital, Seoul, Republic of Korea. jaemoon2@gmail.com.
authors.forename: Jae Moon
authors.initials: JM
authors.lastname: Yun
authors.affiliation: Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. belong@snu.ac.kr.|Health Promotion Center, Seoul National University Hospital, Seoul, Republic of Korea. belong@snu.ac.kr.
authors.forename: BeLong
authors.initials: B
authors.lastname: Cho
authors.affiliation: Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. pjhn@snuh.org.|Health Promotion Center, Seoul National University Hospital, Seoul, Republic of Korea. pjhn@snuh.org.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea. jongil@snu.ac.kr.|Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea. jongil@snu.ac.kr.|Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Republic of Korea. jongil@snu.ac.kr.|Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. jongil@snu.ac.kr.
authors.forename: Jong-Il
authors.initials: JI
authors.lastname: Kim
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics / Q000503:physiopathology; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics*; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005215:Fasting; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D015438:Health Behavior; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009043:Motor Activity; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D012306:Risk; D012907:Smoking / Q000235:genetics / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D001057:Apolipoproteins E; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides