title: MicroRNAs in cancer therapeutics: "from the bench to the bedside".
abstract: MicroRNAs (miRNAs) are non-coding RNA transcripts that regulate physiological processes by targeting proteins directly. Their involvement in research has been robust, and evidence of their regulative functions has granted them the title: master regulators of the human genome. In cancer, they are considered important therapeutic agents, due to the fact that their aberrant expression contributes to disease development, progression, metastasis, therapeutic response and patient overall survival. This has endeavored fields of biomedical sciences to invest in developing and exploiting miRNA-based therapeutics thoroughly. Herein we highlight relevant ongoing/open clinical trials involving miRNAs and cancer.
authors.affiliation: a 1 The University of Texas MD Anderson Cancer Center, Department of Experimental Therapeutics , Houston, TX, USA gcalin@mdanderson.com.|b 2 University of Puerto Rico School of Medicine, Department of Medicine , San Juan, PR, USA.
authors.forename: Paloma del C
authors.initials: Pdel C
authors.lastname: Monroig-Bosque
authors.affiliation: a 1 The University of Texas MD Anderson Cancer Center, Department of Experimental Therapeutics , Houston, TX, USA gcalin@mdanderson.com.|b 2 University of Puerto Rico School of Medicine, Department of Medicine , San Juan, PR, USA.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Rivera
authors.affiliation: a 1 The University of Texas MD Anderson Cancer Center, Department of Experimental Therapeutics , Houston, TX, USA gcalin@mdanderson.com.|c 3 The University of Texas MD Anderson Cancer Center, Center for RNA Interference and Non-Coding RNAs , Houston, TX, USA.
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002986:Clinical Trials as Topic; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: drug development; microRNA; microRNA-based therapeutics