title: Safety Assessment of Ethanolamine and Ethanolamine Salts as Used in Cosmetics.
abstract: The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of ethanolamine and 12 salts of ethanolamine as used in cosmetics. Ethanolamine functions as a pH adjuster. The majority of the salts are reported to function as surfactants, and the others are reported to function as pH adjusters, hair fixatives, or preservatives. The Panel reviewed available animal and clinical data, as well as information from previous relevant CIR reports. Because data were not available for each individual ingredient and because the salts dissociate freely in water, the Panel extrapolated from those previous reports to support safety. The Panel concluded that these ingredients are safe in the present practices of use and concentrations (rinse-off products only) when formulated to be nonirritating, and these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed.
authors.affiliation: Senior Scientific Analyst/Writer, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Monice M
authors.initials: MM
authors.lastname: Fiume
authors.affiliation: Chemist, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Bart A
authors.initials: BA
authors.lastname: Heldreth
authors.affiliation: Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.affiliation: Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.affiliation: Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.affiliation: Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.affiliation: Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Liebler
authors.affiliation: Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.affiliation: Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.affiliation: Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.affiliation: Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.affiliation: Former Director, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: F Alan
authors.initials: FA
authors.lastname: Andersen
mesh_terms: D003257:Consumer Product Safety; D003358:Cosmetics / Q000009:adverse effects* / Q000737:chemistry*; D019856:Ethanolamine / Q000009:adverse effects* / Q000737:chemistry*; D004983:Ethanolamines / Q000009:adverse effects* / Q000737:chemistry*; D006801:Humans; D018570:Risk Assessment; D012492:Salts / Q000009:adverse effects / Q000737:chemistry
chemical_list: D003358:Cosmetics; D004983:Ethanolamines; D012492:Salts; D019856:Ethanolamine
keywords: cosmetics; ethanolamine; safety