title: Neuromagnetic high-frequency oscillations correlate with seizure severity in absence epilepsy.
abstract: OBJECTIVE
  This study quantified the clinical correlation of interictal and ictal neuromagnetic activities from low- to very-high-frequency ranges in childhood absence epilepsy (CAE).
  
  
  METHODS
  Twelve patients with clinically diagnosed drug-naïve CAE were studied using a 275-channel whole-head magnetoencephalography (MEG) system. MEG data were digitized at 6000 Hz and analyzed at both sensor and source levels with multi-frequency analyses.
  
  
  RESULTS
  Neuromagnetic changes from interictal to ictal periods predominantly occurred in medial prefrontal cortex and parieto-occipito-temporal junction in absence seizures. The changes were statistically significant in low-frequency bands only (<30 Hz, p<0.0001). There was a significant correlation between the source strength of ictal high-frequency oscillations (HFOs) in 200-1000 Hz and the number of daily seizures (r=0.734, p<0.01).
  
  
  CONCLUSIONS
  CAE has focal neuromagnetic sources. The transition from interictal to ictal periods is associated with the elevation of low-frequency brain activities. The strength of HFOs reflects the severity of absence seizures.
  
  
  CONCLUSIONS
  Low- and high-frequency MEG signals reveal distinct brain activities in CAE. HFOs is a new biomarker for the study of absence seizures.
authors.affiliation: Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Tang
authors.affiliation: MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45220, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiang
authors.affiliation: Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Shuyang
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Ailiang
authors.initials: A
authors.lastname: Miao
authors.affiliation: Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Huaiting
authors.initials: H
authors.lastname: Ge
authors.affiliation: Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Qingshan
authors.initials: Q
authors.lastname: Guan
authors.affiliation: MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wu
authors.affiliation: MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Qiqi
authors.initials: Q
authors.lastname: Chen
authors.affiliation: MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Neurology, Nanjing Children's Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Neurology, Nanjing Children's Hospital, Nanjing, Jiangsu 210029, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China. Electronic address: lidou2005@126.com.
authors.forename: Xiaoshan
authors.initials: X
authors.lastname: Wang
mesh_terms: D058256:Brain Waves / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D004832:Epilepsy, Absence / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D012640:Seizures / Q000175:diagnosis / Q000503:physiopathology*; D012720:Severity of Illness Index
keywords: Childhood absence epilepsy; High frequency oscillations; Magnetoencephalography