title: Effect of male body mass index on live-birth sex ratio of singletons after assisted reproduction technology.
abstract: OBJECTIVE
  To determine the effect of male body mass index (BMI) on the probability of achieving a live birth and the sex ratio of singletons at birth after IVF and intracytoplasmic sperm injection (ICSI) treatment.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  University-affiliated infertility center.
  
  
  METHODS
  Patients seeking infertility treatment who received IVF or ICSI treatment with autologous oocytes from January 2009 to December 2013.
  
  
  METHODS
  None.
  
  
  METHODS
  Live-birth sex ratio of singletons at birth stratified by male BMI and adjusted by parental age, parental BMI, type of infertility, parity, embryo culture media, and cause of infertility.
  
  
  RESULTS
  A total of 8,490 couples undergoing IVF or ICSI treatment resulted in 39.12% live births and gave birth to 2,377 live birth singletons and 943 twins. There was no significant difference in the live birth rate between groups stratified by BMI. The probability of live births for overweight and obese groups were not decreased compared with the normal-weight group; similar null findings existed in the IVF and ICSI subgroups. Of note, the sex ratio of offspring in the overweight and obese male groups was significantly higher than in the normal-weight group (1.27 vs. 1.07). Male BMI was significantly associated with sex ratio of singletons after adjusting for confounders. In twins, incidences of twins with male-male infants in the overweight/obese group were not different from the normal-weight group.
  
  
  CONCLUSIONS
  Increased male BMI has no effect on live birth success, but has an increased probability of giving birth to male singletons.
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Key Laboratory of Assisted Reproduction, Ministry of Education, and Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, People's Republic of China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Urology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Urology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Jiaming
authors.initials: J
authors.lastname: Mao
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Key Laboratory of Assisted Reproduction, Ministry of Education, and Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, People's Republic of China.
authors.forename: Junsheng
authors.initials: J
authors.lastname: Li
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Key Laboratory of Assisted Reproduction, Ministry of Education, and Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, People's Republic of China.
authors.forename: Xinjie
authors.initials: X
authors.lastname: Zhuang
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Key Laboratory of Assisted Reproduction, Ministry of Education, and Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, People's Republic of China. Electronic address: bysylp@sina.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Key Laboratory of Assisted Reproduction, Ministry of Education, and Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D005220:Fathers; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D008297:Male; D009765:Obesity / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011247:Pregnancy; D018873:Pregnancy Rate; D059285:Pregnancy, Twin; D012189:Retrospective Studies; D012307:Risk Factors; D019849:Sex Determination Processes; D012744:Sex Ratio; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
keywords: Body mass index; intracytoplasmic sperm injection; in vitro fertilization; live birth; sex ratio