title: tBuLi-Mediated One-Pot Direct Highly Selective Cross-Coupling of Two Distinct Aryl Bromides.
abstract: A Pd-catalyzed direct cross-coupling of two distinct aryl bromides mediated by tBuLi is described. The use of [Pd-PEPPSI-IPr] or [Pd-PEPPSI-IPent] as catalyst allows for the efficient one-pot synthesis of unsymmetrical biaryls at room temperature. The key for this selective cross-coupling is the use of an ortho-substituted bromide that undergoes lithium-halogen exchange preferentially.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The Netherlands), Fax: (+31) 50-363-4278.|Present address: Departament de Química Orgànica, Facultat de Química, Universitat de València, Dr. Moliner 50, 46100 Burjassot, València (Spain).
authors.forename: Carlos
authors.initials: C
authors.lastname: Vila
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The Netherlands), Fax: (+31) 50-363-4278.
authors.forename: Sara
authors.initials: S
authors.lastname: Cembellín
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The Netherlands), Fax: (+31) 50-363-4278.
authors.forename: Valentín
authors.initials: V
authors.lastname: Hornillos
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The Netherlands), Fax: (+31) 50-363-4278.
authors.forename: Massimo
authors.initials: M
authors.lastname: Giannerini
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The Netherlands), Fax: (+31) 50-363-4278.|Present address: Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782 Santiago de Compostela (Spain).
authors.forename: Martín
authors.initials: M
authors.lastname: Fañanás-Mastral
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The Netherlands), Fax: (+31) 50-363-4278. b.l.feringa@rug.nl.
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
keywords: N-heterocyclic carbenes; biaryls; cross-coupling; lithium; palladium