title: Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats.
abstract: OBJECTIVE
  Absorption of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to be potentiated when consumed with a high fat meal. However, the effect of different dietary fats on n-3PUFA absorption and postprandial kinetics has not been previously studied.
  
  
  METHODS
  In a randomized cross-over design intervention, postprandial incorporation of LCn-3PUFA into plasma lipids following consumption of a meal rich in either saturated fat or omega-6 polyunsaturated fatty acids (n-6PUFA) was investigated. Healthy adult male and female subjects (n=26) were fed an isocaloric meal containing equivalent amount of either butter or sunflower seed oil supplemented with 1.8grams of LCn-3PUFA (300mg eicosapentaenoic acid, 20:5n-3 and 1500mg docosahexaenoic acid, 22:6n-3).
  
  
  RESULTS
  Postprandial plasma lipids were enriched with saturated fatty acids and linoleic acid (18:2n-6) following consumption of the butter and the sunflower oil containing meals respectively. The increase in plasma 20:5n-3 and 22:6n-3 levels over the 6hour study period was similar in both the saturated and the n-6 fat groups.
  
  
  CONCLUSIONS
  These results suggest that the expected competition between LCn-3PUFA and n-6PUFA at the absorption level is unlikely; therefore competition at the enzymatic level should be primarily responsible for differences in their metabolic and clinical effects. Trial registered with the Australia New Zealand Trial registry as ACTRN12612000654853.
authors.affiliation: Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: cintia.dias@uon.edu.au.
authors.forename: Cintia B
authors.initials: CB
authors.lastname: Dias
authors.affiliation: Hunter Medical Research Institute, University of Newcastle, Australia; Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia. Electronic address: lisa.wood@newcastle.edu.au.
authors.forename: Lisa G
authors.initials: LG
authors.lastname: Wood
authors.affiliation: Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: melinda.phang@health.sa.gov.au.
authors.forename: Melinda
authors.initials: M
authors.lastname: Phang
authors.affiliation: Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: manohar.garg@newcastle.edu.au.
authors.forename: Manohar Lal
authors.initials: ML
authors.lastname: Garg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000493:pharmacokinetics*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007700:Kinetics; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D008055:Lipids
keywords: Plasma fatty acids; Postprandial effects; Saturated fatty acids; n-3 polyunsaturated fatty acids; n-6 polyunsaturated fatty acids