title: Biomarkers of An Autoimmune Skin Disease--Psoriasis.
abstract: Psoriasis is one of the most prevalent autoimmune skin diseases. However, its etiology and pathogenesis are still unclear. Over the last decade, omics-based technologies have been extensively utilized for biomarker discovery. As a result, some promising markers for psoriasis have been identified at the genome, transcriptome, proteome, and metabolome level. These discoveries have provided new insights into the underlying molecular mechanisms and signaling pathways in psoriasis pathogenesis. More importantly, some of these markers may prove useful in the diagnosis of psoriasis and in the prediction of disease progression once they have been validated. In this review, we summarize the most recent findings in psoriasis biomarker discovery. In addition, we will discuss several emerging technologies and their potential for novel biomarker discovery and diagnostics for psoriasis.
authors.affiliation: Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
authors.forename: Taylor E
authors.initials: TE
authors.lastname: Hinchliffe
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA. Electronic address: twu13@Central.UH.EDU.
authors.forename: Tianfu
authors.initials: T
authors.lastname: Wu
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis*; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D006801:Humans; D055442:Metabolome; D020543:Proteome / Q000378:metabolism; D011565:Psoriasis / Q000175:diagnosis*; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: Biomarker; Genomics; Metabolomics; Proteomics; Psoriasis