title: Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity.
abstract: Candida albicans, Candida tropicalis, Candida grabrata, and Cryptococcus neoformans are causative pathogens of opportunistic diseases in immunocompromised human patients. Silkworms are killed by injection of these pathogenic fungi into their hemolymph. In this paper, we describe recent results by our laboratory and other researchers using gene-deficient strains of these pathogenic fungi. The silkworm is considered to be a useful model animal for understanding the pathogenicity of these fungi. Silkworms are also beneficial for evaluating therapeutically active anti-fungal reagents.
authors.affiliation: Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo.
authors.forename: Masaki
authors.initials: M
authors.lastname: Ishii
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sekimizu
mesh_terms: D000818:Animals; D012831:Bombyx / Q000382:microbiology*; D002175:Candida / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity*; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity*; D004195:Disease Models, Animal; D006801:Humans; D014774:Virulence / Q000235:genetics