title: Maternal serum copeptin concentrations in early- and late-onset pre-eclampsia.
abstract: OBJECTIVE
  Early-onset pre-eclampsia is primarily associated with placental dysfunction, whereas late-onset pre-eclampsia is defined as a maternal constitutional disorder. As a protein cosynthesized with vasopressin, copeptin is a potential marker of metabolic syndrome and insulin resistance, which shares similar risk factors with pre-eclampsia. The aim of this study was to investigate the copeptin levels in patients with early-onset and late-onset pre-eclampsia.
  
  
  METHODS
  A total of 80 pregnant women receiving antenatal and obstetric care were recruited. The patients were subdivided into four groups: Early-onset pre-eclampsia (n = 20), late-onset pre-eclampsia (n = 20), and two control groups of similar gestational ages for both pre-eclamptic groups (n = 20 in each group). The maternal serum copeptin levels were measured using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The mean copeptin levels were 0.92 ± 0.57 ng/mL and 1.65 ± 0.95 ng/mL in the early-onset and late-onset pre-eclampsia groups, respectively. These values were higher compared with the control groups (0.54 ± 0.25 ng/mL and 1.15 ± 0.94 ng/mL, respectively). However, the difference was only statistically significant in the early-onset pre-eclampsia group (p = 0.011). Copeptin levels were associated only with gestational age and systolic-diastolic blood pressure.
  
  
  CONCLUSIONS
  Our results suggest that copeptin levels might be useful in the evaluation of the severity of pre-eclampsia. However, copeptin might be involved in early- rather than late-onset pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: drabdtuten@gmail.com.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Tuten
authors.affiliation: Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Oncul
authors.affiliation: Department of Medical Biochemistry, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Kucur
authors.affiliation: Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Metehan
authors.initials: M
authors.lastname: Imamoglu
authors.affiliation: Department of Medical Biochemistry, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ozlem Balcı
authors.initials: OB
authors.lastname: Ekmekci
authors.affiliation: Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Abdullah Serdar
authors.initials: AS
authors.lastname: Acıkgoz
authors.affiliation: Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Fatma Selcen
authors.initials: FS
authors.lastname: Cebe
authors.affiliation: Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Yesilbas
authors.affiliation: Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Rıza
authors.initials: R
authors.lastname: Madazlı
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D008423:Maternal Age; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011295:Prenatal Care / Q000379:methods; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D013997:Time Factors
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins
keywords: copeptin; early-onset pre-eclampsia; gestational age; late-onset pre-eclampsia; pre-eclampsia