title: Solid hemoglobin-polymer phantoms for evaluation of biophotonic systems.
abstract: Stable tissue phantoms that incorporate the spectral absorption properties of hemoglobin would benefit a wide range of biophotonic technologies. Toward this end, we have developed and validated a novel polymer material incorporating hemoglobin. Our solid hemoglobin-polymer (SHP) material is fabricated by mixing liquid silicone base with a hemoglobin solution, followed by sonication and low temperature curing. The optical properties of samples were determined over 450-1000 nm using the inverse adding-doubling method and the Beer-Lambert law. Measurements indicated SHP optical stability over four months. Near-infrared spectroscopy and hyperspectral imaging measurements of SHP samples were performed to demonstrate the utility of this approach. SHP materials have the potential to improve tissue-simulating phantoms used for development, evaluation, and standardization of optical devices for oximetry and other applications.
authors.forename: Hyounguk
authors.initials: H
authors.lastname: Jang
authors.forename: T Joshua
authors.initials: TJ
authors.lastname: Pfefer
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
mesh_terms: D006454:Hemoglobins / Q000737:chemistry*; D061848:Optical Imaging / Q000295:instrumentation*; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D012828:Silicones / Q000737:chemistry; D013055:Spectrophotometry, Infrared / Q000295:instrumentation*
chemical_list: D006454:Hemoglobins; D012828:Silicones; C079129:hemoglobin polymer