title: Jitter reduction technique for acoustic radiation force impulse microscopy via photoacoustic detection.
abstract: We demonstrate a jitter noise reduction technique for acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), which promises to be capable of measuring cell mechanics. To reduce the jitter noise induced by Q-switched pulsed laser operated at high repetition frequency, photoacoustic signals from the surface of an ultrasound transducer are aligned by cross-correlation and peak-to-peak detection, respectively. Each method is then employed to measure the displacements of a target sample in an agar phantom and a breast cancer cell due to ARFI application, followed by the quantitative comparison between their performances. The suggested methods for PA-ARFI significantly reduce jitter noises, thus allowing us to measure displacements of a target cell due to ARFI application by less than 3 μm.
authors.forename: Bong Jin
authors.initials: BJ
authors.lastname: Kang
authors.forename: Changhan
authors.initials: C
authors.lastname: Yoon
authors.forename: Jin Man
authors.initials: JM
authors.lastname: Park
authors.forename: Jae Youn
authors.initials: JY
authors.lastname: Hwang
authors.forename: K Kirk
authors.initials: KK
authors.lastname: Shung