title: [Analysis of risk factors of Budd-Chiari syndrome complicated with hepatocellular carcinoma].
abstract: OBJECTIVE
  To investigate the risk factors of Budd-Chiari syndrome (B-CS) complicated with hepatocellular carcinoma (HCC).
  
  
  METHODS
  The clinical data of 30 patients with B-CS complicated with HCC treated in the First Affiliated Hospital of Zhengzhou University from December 2012 to November 2014 were analyzed retrospectively, 106 another patients were selected randomly as control group in the same term. Gender, age, medical history, type of B-CS, hemoglobin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, Child-Pugh classification, portal vein diameter, HBV infection and drinking history were recorded and analyzed between the two groups. Univariate analysis and unconditional Logistic regression model were performed to screen corresponding risk factors. Area under curve (AUC) was calculated according to receiver operator characteristic (ROC) curve to evaluate the diagnostic value of each indicator.
  
  
  RESULTS
  Univariate analysis showed that there were no statistical differences in gender (χ² =0.001), age (t=0.317), medical history (t=-0.906), type of B-CS (χ² =2.894), ALT (t=-1.581), Child-Pugh classification (Z=-0.777), HBV infection (χ² =0.016) and drinking history (χ² =0.285) between the two groups (all P > 0.05), but the hemoglobin (t=3.370) and albumin (t=2.152) in HCC group were lower and AST (t=-2.425) and portal vein diameter (t=-2.554) were higher than that in the other group, and the differences were statistically significant (all P <0.05). The results of unconditional Logistic regression model analysis indicated that hemoglobin, AST and portal vein diameter were independent risk factors of B-CS complicated with HCC (OR=0.972, 1.015, 1.206; P=0.004, 0.022, 0.012). ROC curve analysis indicated that the AUC of AST, hemoglobin and portal vein diameter was 0.704, 0.324 and 0.624, the predicate value was, in order, AST, portal vein diameter, hemoglobin.
  
  
  CONCLUSIONS
  Hemoglobin, AST and portal vein diameter are independent risk factors of B-CS complicated with HCC.
authors.affiliation: Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Email: dangxw1001@163.com.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Dang
authors.affiliation: Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Luhao
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Suxin
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Shaokai
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Kunkun
authors.initials: K
authors.lastname: Fu
authors.affiliation: Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Peiqin
authors.initials: P
authors.lastname: Xu
mesh_terms: D019540:Area Under Curve; D001219:Aspartate Aminotransferases / Q000378:metabolism; D006502:Budd-Chiari Syndrome / Q000150:complications*; D006528:Carcinoma, Hepatocellular / Q000150:complications*; D016022:Case-Control Studies; D002648:Child; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications*; D016015:Logistic Models; D011169:Portal Vein / Q000473:pathology; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D006454:Hemoglobins; D001219:Aspartate Aminotransferases