title: Treatment Outcome in Depressed Latinos Predicted by Concomitant Psychosislike Symptoms.
abstract: We compared treatment response (≥50 decrease in Nine-Item Patient Health Questionnaire total score) among 24 Latinos with major depressive disorder, presenting with and without specific psychosislike symptoms: A, hearing noises or house sounds, B, hearing voices calling one's name, C, seeing fleeting visions such as shadows, and D, symptoms more likely to be truly psychotic (e.g., poorly defined and short-lasting voices [other than B], fleeting paranoid ideation, or fleeting ideas of reference). 18 subjects (75%) endorsed symptoms of cluster A, 12 (50%) of cluster B, 10 (31%) of cluster C, and 12 (50%) of cluster D. Only subjects who reported symptoms from the D cluster exhibited significantly unfavorable depressive outcomes (compared to those with absence of D symptoms). The authors propose a phenomenological differentiation between benign psychosislike symptoms (clusters A-C) and the expression of the psychotic continuum (cluster D) in depressed Latinos.
authors.affiliation: *Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston; and †North Suffolk Mental Health Association, Chelsea, MA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Cassano
authors.forename: Nhi-Ha
authors.initials: NH
authors.lastname: Trinh
authors.forename: Trina
authors.initials: T
authors.lastname: Chang
authors.forename: Cristina
authors.initials: C
authors.lastname: Cusin
authors.forename: Lauren
authors.initials: L
authors.lastname: Fisher
authors.forename: Paola
authors.initials: P
authors.lastname: Pedrelli
authors.forename: Maren
authors.initials: M
authors.lastname: Nyer
authors.forename: Daniel Ju Hyung
authors.initials: DJ
authors.lastname: Kim
authors.forename: Jonathan
authors.initials: J
authors.lastname: Alpert
authors.forename: David
authors.initials: D
authors.lastname: Mischoulon
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000208:ethnology / Q000523:psychology*; D005260:Female; D006630:Hispanic or Latino / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000150:complications* / Q000188:drug therapy / Q000208:ethnology / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents