title: A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells.
abstract: Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4(+)CD8(+) T cells did not have strong antiviral activity.
authors.affiliation: Departments of Medicine ; Oncology , Johns Hopkins School of Medicine , Baltimore, Maryland.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Durand
authors.affiliation: Departments of Medicine.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buckheit
authors.affiliation: Departments of Medicine.
authors.forename: Maria
authors.initials: M
authors.lastname: Salgado
authors.affiliation: Departments of Medicine.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Pohlmeyer
authors.affiliation: Departments of Medicine.
authors.forename: Victoria E
authors.initials: VE
authors.lastname: Walker-Sperling
authors.affiliation: Departments of Medicine.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Hegarty
authors.affiliation: Departments of Medicine ; Oncology , Johns Hopkins School of Medicine , Baltimore, Maryland.
authors.forename: Richard F
authors.initials: RF
authors.lastname: Ambinder
authors.affiliation: Departments of Medicine.
authors.forename: Joel N
authors.initials: JN
authors.lastname: Blankson
keywords: AIDS; HIV; HIV controllers; double-positive cells; elite controllers; immune activation; long-term nonprogressors; viremic controllers