title: Double Detection of Mycotoxins Based on SERS Labels Embedded Ag@Au Core-Shell Nanoparticles.
abstract: A sensitive surface-enhanced Raman scattering (SERS) signal dependent double detection of mycotoxins is achieved for the first time, without the aid of nucleic acid amplification strategies. SERS labels embedded Ag@Au core-shell (CS) nanoparticles (NPs) as novel SERS tags are successfully prepared through a galvanic replacement-free deposition. SERS tags produce stable and quantitative SERS signal, emerging from the plasmonic coupling at the junction of Ag core and Au shell. SERS tags engineered Raman aptasensors are developed for the double detection of ochratoxin A (OTA) and aflatoxin B1 (AFB1) in maize meal. The limits of detection (LODs) are as low as 0.006 ng/mL for OTA and 0.03 ng/mL for AFB1. The developed protocol can be extended to a large set of different SERS tags for the sensitive detection of multiple targets that possess different lengths of aptamers.
authors.affiliation: The Key Lab of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: The Key Lab of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Yang
authors.affiliation: The Key Lab of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Luo
authors.affiliation: The Key Lab of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Yang
authors.affiliation: The Key Lab of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Manli
authors.initials: M
authors.lastname: Li
authors.affiliation: The Key Lab of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Qijun
authors.initials: Q
authors.lastname: Song
mesh_terms: D006046:Gold / Q000737:chemistry*; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D009183:Mycotoxins / Q000032:analysis*; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D009183:Mycotoxins; D012834:Silver; D006046:Gold
keywords: Ag core; SERS; double detection; embed; mycotoxins