title: Site selective syntheses of [(3)H]omeprazole using hydrogen isotope exchange chemistry.
abstract: Omeprazole (Prilosec®) is a selective and irreversible proton pump inhibitor used to treat various medical conditions related to the production of excess stomach acids. It functions by suppressing secretion of those acids. Radiolabeled compounds are commonly employed in the drug discovery and development process to support efforts including library screening, target identification, receptor binding, assay development and validation and safety assessment. Herein, we describe synthetic approaches to the controlled and selective labeling of omeprazole with tritium via hydrogen isotope exchange chemistry. The chemistry may also be used to prepare tritium labeled esomeprazole (Nexium®), the active pure (S)-enantiomer of omeprazole.
authors.affiliation: Department of Process Chemistry, Merck & Co., Inc., Rahway, NJ, 07065, United States.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Pollack
authors.affiliation: Department of Process Chemistry, Merck & Co., Inc., Rahway, NJ, 07065, United States.
authors.forename: David J
authors.initials: DJ
authors.lastname: Schenk
mesh_terms: D009853:Omeprazole / Q000138:chemical synthesis*; D054328:Proton Pump Inhibitors / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D014316:Tritium / Q000737:chemistry*
chemical_list: D054328:Proton Pump Inhibitors; D019275:Radiopharmaceuticals; D014316:Tritium; D009853:Omeprazole
keywords: Nexium; Prilosec; esomeprazole; hydrogen isotope exchange; omeprazole; tritium