title: Effect of Cellulose Acetate Beads on the Release of Transforming Growth Factor-β.
abstract: Transforming growth factor-β (TGF-β) is released by activated platelets and induces the differentiation of T-helper 17 from naïve T cells. Contact between blood and cellulose acetate (CA) beads induces cytokine release, although their inflammatory effects on TGF-β release are unclear. We aimed to clarify the effect of CA beads on the release of TGF-β in vitro. We incubated peripheral blood with and without CA beads and measured platelets and TGF-β. Compared with blood samples incubated without beads, the platelet count and amount of TGF-β significantly decreased in blood samples incubated with CA beads. In conclusion, CA beads inhibited the release of TGF-β from adsorbed platelets. The biological effects of this reduction of TGF-β release during platelet adsorption to CA beads need further clarification.
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Nishise
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Abe
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Eiki
authors.initials: E
authors.lastname: Nomura
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sato
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sasaki
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Iwano
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Yagi
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sakuta
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Rika
authors.initials: R
authors.lastname: Shibuya
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Mizumoto
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Nana
authors.initials: N
authors.lastname: Kanno
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
mesh_terms: D000327:Adsorption / Q000276:immunology; D001672:Biocompatible Materials / Q000494:pharmacology; D001781:Blood Component Removal / Q000295:instrumentation / Q000379:methods; D001792:Blood Platelets / Q000378:metabolism; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D015539:Platelet Activation / Q000276:immunology*; D010976:Platelet Count / Q000379:methods; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D016212:Transforming Growth Factor beta; C005062:acetylcellulose; D002482:Cellulose
keywords: Adsorption; Blood platelets; Cellulose acetate; Inflammatory bowel diseases; Transforming growth factor-β