title: A systematic review of implant outcomes in treated periodontitis patients.
abstract: OBJECTIVE
  To investigate the effect of treated periodontitis on implant outcomes in partially edentulous individuals compared with periodontally healthy patients.
  
  
  METHODS
  Longitudinal studies reporting on implant survival, success, incidence of peri-implantitis, bone loss and periodontal status, and on partially dentate patients with a history of treated periodontitis were included.
  
  
  RESULTS
  The search yielded 14,917 citations. Twenty-seven publications met the inclusion criteria for qualitative data synthesis. Implant success and survival were higher in periodontally healthy patients, whilst bone loss and incidence of peri-implantitis was increased in patients with history of treated periodontitis. There was a higher tendency for implant loss and biological complications in patients previously presenting with severe forms of periodontitis. The strength of the evidence was limited by the heterogeneity of the included studies in terms of study design, population, therapy, unit of analysis, inconsistent definition of baselines and outcomes, as well as by the inadequate reporting of statistical analysis and accounting for confounding factors; thus, meta-analysis could not be performed.
  
  
  CONCLUSIONS
  Implants placed in patients treated for periodontal disease are associated with higher incidence of biological complications and lower success and survival rates than those placed in periodontally healthy patients. Severe forms of periodontal disease are associated with higher rates of implant loss. However, it is critical to develop well-designed, long-term prospective studies to provide further substantive evidence on the association of these outcomes.
authors.affiliation: Department of Clinical Research, Periodontology Unit, UCL Eastman Dental Institute, London, UK.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Sousa
authors.affiliation: Centre for Adult Oral Health, Periodontology Unit, QMUL Bart's and The London School of Dentistry and Hospital, London, UK.
authors.forename: Nikos
authors.initials: N
authors.lastname: Mardas
authors.affiliation: Federal University of Pernambuco, Recife-Pernambuco, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: Farias
authors.affiliation: Biostatistics Unit, UCL Eastman Dental Institute, London, UK.
authors.forename: Aviva
authors.initials: A
authors.lastname: Petrie
authors.affiliation: Department of Clinical Research, Periodontology Unit, UCL Eastman Dental Institute, London, UK.|International Centre for Evidence-Based Oral Health, UCL Eastman Dental Institute, London, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Needleman
authors.affiliation: Department of Microbial Diseases, UCL Eastman Dental Institute, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Spratt
authors.affiliation: Department of Clinical Research, Periodontology Unit, UCL Eastman Dental Institute, London, UK.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Donos
mesh_terms: D015921:Dental Implants; D019232:Dental Restoration Failure; D006801:Humans; D057873:Peri-Implantitis / Q000209:etiology; D010518:Periodontitis / Q000150:complications*
chemical_list: D015921:Dental Implants
keywords: Periodontology; clinical assessment; clinical research; clinical trials; diagnosis; epidemiology; patient centered outcomes; statistics