title: Bradycardia caused by intravenous nicardipine in an elderly patient with acute ischemic infarct.
abstract: Nicardipine is a dihydropyridine calcium-channel blocker that is frequently used in the acute treatment of hypertension in the emergency department (ED). Reflex sympathetic tachycardia is a well-described side effect of this medication. Two experimental studies and 1 anesthesia case report, however, have previously described nicardipine-induced bradycardia as a very rare side effect. We report the case of an elderly patient with an acute ischemic stroke who developed nicardipine-induced bradycardia in the ED.
authors.affiliation: Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Abboud
authors.affiliation: Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA 02115. Electronic address: sarahfrasure@yahoo.com.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Frasure
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001919:Bradycardia / Q000139:chemically induced*; D002545:Brain Ischemia / Q000150:complications*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007262:Infusions, Intravenous; D008297:Male; D009529:Nicardipine / Q000008:administration & dosage / Q000009:adverse effects*; D020521:Stroke / Q000150:complications*
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D009529:Nicardipine