title: Dexmedetomidine Infusion to Control Agitation due to Anticholinergic Toxidromes in Adolescents, a Case Series.
abstract: Dexmedetomidine is an α2-adrenergic agonist approved by the US Food and Drug Administration for the sedation of adults who are intubated on mechanical ventilation and in non-intubated adults who are undergoing surgical procedures. However, it has also recently become a commonly used sedative agent in varied clinical settings for the pediatric patient as well. We present the use of dexmedetomidine for sedation in a unique clinical scenario, the severely agitated and combative patient following the intentional misuse of anticholinergic drugs. Its applications in this situation are discussed, and previous reports in the literature are reviewed.
authors.affiliation: Section of Pediatric Critical Care and Department of Pediatrics.
authors.forename: Samantha W
authors.initials: SW
authors.lastname: Gee
authors.affiliation: Section of Pediatric Critical Care and Department of Pediatrics ; Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital and Ohio State University, Columbus.
authors.forename: Ada
authors.initials: A
authors.lastname: Lin
authors.affiliation: Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital and Ohio State University, Columbus.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tobias
keywords: adolescent; anticholinergic toxidrome; dexmedetomidine; toxicity