title: Micromanaging metabolism-a role for miRNAs in teleost energy metabolism.
abstract: MicroRNAs (miRNAs) are small, non-protein coding RNA sequences, which are found in most eukaryotes. Since their initial discovery, miRNAs have emerged as important regulators of many biological processes. One of the most important processes profoundly regulated by miRNAs is energy metabolism. Traditionally, metabolic functions of miRNAs have been studied in genome-sequenced mammalian organisms, especially the mouse model. However, partially driven by commercial interest in aquaculture, increasingly feasible large-scale molecular techniques have resulted in the characterization of miRNA repertoires, and importantly, several genome sequences of several (commercially important) teleost species, which also hold important roles as research models in the comparative physiology of energy metabolism. This review aims to introduce the recent advances in miRNA research in teleost fish and to describe the current knowledge of miRNA function in teleost energy metabolism. The most pressing research needs and questions to determine metabolic roles of miRNAs in teleost models are presented, as well as applicable technical approaches and current bottlenecks. Rainbow trout, which possess the advantages of newly available molecular tools and a long history as comparative research model in teleost energy metabolism, are discussed as a promising research model to address these questions.
authors.affiliation: College of Pharmacy, Department of Toxicology and Pharmacology, University of Austin at Texas, 107 W Dean Keeton, Austin, TX 78712, USA.
authors.forename: Jan A
authors.initials: JA
authors.lastname: Mennigen
mesh_terms: D000818:Animals; D054750:Ecotoxicology; D004734:Energy Metabolism / Q000187:drug effects / Q000235:genetics*; D005399:Fishes / Q000235:genetics* / Q000378:metabolism* / Q000502:physiology; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: Energy metabolism; Fish; MicroRNA; Non-coding RNA; Rainbow trout