title: [Protection and Mechanism of Qingyuan Shenghua Decoction on Multiple Organs of Sepsis Patients after Bone Trauma].
abstract: OBJECTIVE
  To observe the protection of Qingyuan Shenghua Decoction (QSD) on multiple organs of sepsis patients after bone trauma, and to preliminarily explore its mechanism.
  
  
  METHODS
  Totally 60 sepsis patients after bone trauma were randomly assigned to the treatment group and the control group according to random digit table, 30 in each group. All patients received routine Western medical treatment. Patients in the treatment group additionally took QSD or were nasally fed with QSD, one dose per day for 1 week. Changes of WBC, oxygenation index (PaO2/FiO2), serum creatinine (SCr), total bilirubin (TBIL), aspartate aminotransferase (AST), fibrinogen (FIB), D-dimer (DD), activated partial thromboplastin time (APTT), pro-calcitonin (PCT), C-reactive protein (CRP), heart rate (HR), mean arterial pressure (MAP), intra-abdominal pressure, scores for Acute Physiology and Chronic Health Evaluation II (APACHE II), sequential organ failure assessment (SOFA) scores were observed before treatment and on day 1, 3 and 7 after treatment.
  
  
  RESULTS
  Compared with the control group at the same time point, MAP increased at post-treatment day 1 and 3; CRP, APTT, HR, SCr, TBIL, AST, intra-abdominal pressure at post-treatment day 3 obviously decreased in the treatment group (P < 0.05, P < 0.01). WBC, SOFA scores, PCT, CRP, APACHE II, APTT, D-D, HR, SCr, TBIL, AST and intra-abdominal pressure significantly decreased; FIB, MAP and PaO2/FiO2 obviously increased at post-treatment day 7 (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  QSD had good protective effect on multiple organ function in sepsis patients after bone trauma, and its mechanism might be related with effectively clearing endotoxin, alleviating inflammatory reactions, and fighting against coagulation dysfunction.
authors.forename: Feng-ying
authors.initials: FY
authors.lastname: Wang
authors.forename: Tie-zhu
authors.initials: TZ
authors.lastname: Yang
authors.forename: Song-lin
authors.initials: SL
authors.lastname: Ming
authors.forename: Li-li
authors.initials: LL
authors.lastname: You
authors.forename: Li-hui
authors.initials: LH
authors.lastname: Xu
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.forename: Qing-feng
authors.initials: QF
authors.lastname: Song
authors.forename: Liang-ye
authors.initials: LY
authors.lastname: Li
mesh_terms: D018806:APACHE; D001777:Blood Coagulation; D001847:Bone Diseases / Q000150:complications*; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D010314:Partial Thromboplastin Time; D011498:Protein Precursors / Q000378:metabolism; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D004365:Drugs, Chinese Herbal; D005338:Fibrin Fibrinogen Degradation Products; D011498:Protein Precursors; C000590839:Shenghua Decoction; C036309:fibrin fragment D; D002116:Calcitonin; D002097:C-Reactive Protein