title: Acute Necrotizing Pancreatitis Following Olanzapine Treatment and 759C/T Polymorphism of HTR2C Gene: A Case Report.
abstract: Acute pancreatitis can be attributed to numerous potential causes, such as alcohol abuse, chololithiasis, infection, lesions, tumors, hypercalcemia, hyperlipidemia, and medications. Among psychotropic medications, the use of some atypical antipsychotics, such as clozapine, olanzapine, quetiapine and risperidone, has been implicated in the development of acute pancreatitis, although the underlying mechanism has not been clarified. We describe the case of a young man with no other major medical problems, alcohol abuse or predisposing factors, who developed acute necrotizing pancreatitis following olanzapine administration, possibly through severe elevation of serum triglycerides. A pharmacogenomic analysis revealed the presence of the 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C) -759C genotype which is related to increased risk for metabolic syndrome.
authors.affiliation: Second Department of Psychiatry, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece erizos@med.uoa.gr.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Rizos
authors.affiliation: Second Department of Psychiatry, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Tournikioti
authors.affiliation: Second Department of Psychiatry, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Alevyzakis
authors.affiliation: Second Department of Internal Medicine-Propaedeutic, Endocrine Unit, Research Institute and Diabetes Center, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
authors.forename: Melpomeni
authors.initials: M
authors.lastname: Peppa
authors.affiliation: Second Department of Psychiatry, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Papazaxos
authors.affiliation: Second Department of Psychiatry, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Zorbas
authors.affiliation: Second Department of Psychiatry, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Michopoulos
authors.affiliation: Second Department of Psychiatry, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Liappas
authors.affiliation: Second Department of Psychiatry, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece Second Department of Internal Medicine-Propaedeutic, Endocrine Unit, Research Institute and Diabetes Center, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Papageorgiou
authors.affiliation: Second Department of Psychiatry, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Douzenis
mesh_terms: D000483:Alleles; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D057915:Drug Substitution; D006239:Haplotypes; D006801:Humans; D008297:Male; D000077152:Olanzapine; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis / Q000209:etiology*; D020641:Polymorphism, Single Nucleotide; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D044405:Receptor, Serotonin, 5-HT2C; D001569:Benzodiazepines; D000077152:Olanzapine
keywords: -759C/T HTR2C genetic polymorphism; Acute pancreatitis; olanzapine