title: The time course and characteristics of procedural learning in schizophrenia patients and healthy individuals.
abstract: Patients with schizophrenia have deficits in some types of procedural learning. Several mechanisms contribute to this learning in healthy individuals, including statistical and sequence-learning. To find preserved and impaired learning mechanisms in schizophrenia, we studied the time course and characteristics of implicitly introduced sequence-learning (SRT task) in 15 schizophrenia patients (seven mild and eight severe) and nine healthy controls, in short sessions over multiple days (5-22). The data show speed gains of similar magnitude for all groups, but the groups differed in overall speed and in the characteristics of the learning. By analyzing the data according to its spatial-position and temporal-order components, we provide evidence for two types of learning that could differentiate the groups: while the learning of the slower, severe group was dominated by statistical learning, the control group moved from a fast learning phase of statistical-related performance to subsequence learning (chunking). Our findings oppose the naïve assumption that a similar gain of speed reflects a similar learning process; they indicate that the slower performance reflects the activation of a different motor plan than does the faster performance; and demonstrate that statistical learning and subsequence learning are two successive stages in implicit sequence learning, with chunks inferred from prior statistical computations. Our results indicate that statistical learning is intact in patients with schizophrenia, but is slower to develop in the severe patients. We suggest that this slow learning rate and the associated slow performance contribute to their deficit in developing sequence-specific learning by setting a temporal constraint on developing higher order associations.
authors.affiliation: The Institute for Vision Research Kiron, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Adini
authors.affiliation: Department of Human Biology, University of Haifa Haifa, Israel ; Department of Optometry, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan, Israel.
authors.forename: Yoram S
authors.initials: YS
authors.lastname: Bonneh
authors.affiliation: Day Care Unit and the Laboratory of Imaging and Brain Stimulation, Kfar Shaul hospital, Jerusalem Center for Mental Health Jerusalem, Israel.
authors.forename: Seva
authors.initials: S
authors.lastname: Komm
authors.affiliation: Biostats Statistical Consulting Ltd Modiin, Israel.
authors.forename: Lisa
authors.initials: L
authors.lastname: Deutsch
authors.affiliation: Jerusalem Center for Mental Health, Hebrew University Jerusalem, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Israeli
keywords: chunking; motor learning; procedural learning; schizophrenia; sequence learning; serial reaction-time task; skill learning; statistical learning