title: Releasing the Brake on Oncolytic Viral Therapy.
abstract: Oncolytic virus that selectively targets and eradicates tumor cells and immune checkpoint blockade that unleashes host antitumor immune responses show synergistic effects against cancer. This combination holds great promise for future treatment of a broad range of cancers in patients. Clin Cancer Res; 21(24); 5417-9. ©2015 AACR.See related article by Rojas et al., p. 5543.
authors.affiliation: Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia. phil.darcy@petermac.org clare.slaney@petermac.org.
authors.forename: Clare Y
authors.initials: CY
authors.lastname: Slaney
authors.affiliation: Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia. Department of Pathology, University of Melbourne, Parkville, Australia. Department of Immunology, Monash University, Clayton, Victoria, Australia. phil.darcy@petermac.org clare.slaney@petermac.org.
authors.forename: Phillip K
authors.initials: PK
authors.lastname: Darcy
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000628:therapy; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses; D014779:Virus Replication