title: Understanding Off-Label Use and Reference Blood Flows in Modern Membrane Oxygenators.
abstract: This editorial will address two issues that are still a source of global controversy and confusion in present day perfusion practice. Membrane oxygenators are designed and tested to a set of stringent flow standards prior to their release from every manufacturer. But how well do we know the iatrogenic consequences of pushing these devices beyond their maximum rated limits? In addition, how well do we know the meaning of the term 'AAMI Reference Flow' as it relates to the Manufacturers Maximum Rated Flow?
authors.forename: Gerard J
authors.initials: GJ
authors.lastname: Myers
mesh_terms: D006439:Hemodynamics; D006801:Humans; D056687:Off-Label Use; D010107:Oxygenators, Membrane; D015424:Reperfusion