title: Nanosuspensions of poorly water-soluble drugs prepared by bottom-up technologies.
abstract: In recent years, nanosuspension has been considered effective in the delivery of water-soluble drugs. One of the main challenges to effective drug delivery is designing an appropriate nanosuspension preparation approach with low energy input and erosion contamination, such as the bottom-up method. This review focuses on bottom-up technologies for preparation of nanosuspensions. The features and advantages of drug nanosuspension, including bottom-up methods as well as the corresponding characterization techniques, solidification methods, and drug delivery dosage forms, are discussed in detail. Certain limitations of commercial nanosuspension products are also reviewed.
authors.affiliation: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, Shandong, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.affiliation: Hospital, Qilu University of Technology, Jinan 250353, Shandong, PR China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, PR China.
authors.forename: Huanxin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, Shandong, PR China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, Shandong, PR China. Electronic address: wangyancai1999@163.com.
authors.forename: Lulu
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, Shandong, PR China.
authors.forename: Shushu
authors.initials: S
authors.lastname: Tian
authors.affiliation: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, Shandong, PR China.
authors.forename: Yancai
authors.initials: Y
authors.lastname: Wang
mesh_terms: D016503:Drug Delivery Systems; D015195:Drug Design; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013535:Suspensions; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D013535:Suspensions; D014867:Water
keywords: Bottom-up; Nanoprecipitation; Nanosuspension; Solidification; Stability