title: Changes in nuclear receptor corepressor RIP140 do not influence mitochondrial content in the cortex.
abstract: Changes in nuclear receptor interacting protein 140 (RIP140) influences mitochondrial content in skeletal muscle; however, the translation of these findings to the brain has not been investigated. The present study examined the impact of overexpressing and ablating RIP140 on mitochondrial content in muscle and the cortex through examining mRNA, mtDNA, and mitochondrial protein content. Our results show that changes in RIP140 expression significantly alters markers of mitochondrial content in skeletal muscle but not the brain.
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.|Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: Eric A F
authors.initials: EA
authors.lastname: Herbst
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.|Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: Arend
authors.initials: A
authors.lastname: Bonen
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.|Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: Graham P
authors.initials: GP
authors.lastname: Holloway
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D000078723:Nuclear Receptor Interacting Protein 1
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C000627127:NRIP1 protein, human; D009687:Nuclear Proteins; D000078723:Nuclear Receptor Interacting Protein 1
keywords: PGC-1α; biogenèse mitochondriale; brain; cerveau; contenu mitochondrial; contrôle transcriptionnel; mitochondrial biogenesis; mitochondrial content; transcriptional control