title: [One-year results on the safety and efficacy of the InnFocus MicroShunt™ depending on placement and concentration of mitomycin C].
abstract: OBJECTIVE
  To compare intraocular pressure (IOP) at one year with the InnFocus MicroShunt(®) with or without cataract surgery with according to placement and concentration of mitomycin C (MMC) DESIGN: A retrospective two-center, two-surgeon study (France and Dominican Republic).
  
  
  METHODS
  Adults with POAG requiring filtering surgery. One MicroShunt(®) was placed in one eye of each patient. The effect of concentration and site of application of MMC was assessed by IOP and medication reduction at one year.
  
  
  RESULTS
  Eighty-seven eyes were studied with one-year follow-up. Twenty-three eyes treated with 0.4 mg/mL MMC close to the limbus demonstrated a 55% reduction in IOP from 23.8 ± 5.3 at baseline to 10.7 ± 2.8 mmHg at one year. Topical glaucoma medication/patient was reduced 85% from 2.4 ± 0.9 to 0.3 ± 0.8. Thirty-one eyes treated with 0.2mg/mL MMC close to the limbus demonstrated a 52% reduction in IOP from 27.9 ± 6.7 at baseline to 13.3 ± 3.3 mmHg at one year. Topical glaucoma medication/patient was reduced 88% from 2.5 ± 1.4 to 0.5 ± 1.0. Thirty-three eyes treated with 0.4 mg/mL MMC deep in the pocket demonstrated a 38% reduction in IOP from 25.4 ± 7.9 at baseline to 15.7 ± 4.6 mmHg at one year. Topical glaucoma medication/patient was reduced 72% from 2.9 ± 1.0 to 0.8 ± 1.3. There were no sight-threatening long-term adverse events.
  
  
  CONCLUSIONS
  The InnFocus MicroShunt(®) is a filtering surgery whose efficacy is related to the location of application and concentration of MMC used.
authors.affiliation: Pôle ophtalmologique, clinique Mutualiste, 46/54, avenue du Dr-Albert-Schweitzer, 33600 Pessac, France. Electronic address: isabelleriss@orange.fr.
authors.forename: I
authors.initials: I
authors.lastname: Riss
authors.affiliation: Centro Laser, Santo Domingo, Calle Padre Fantino Falco 3, Santo Domingo, République dominicaine.
authors.forename: J
authors.initials: J
authors.lastname: Batlle
authors.affiliation: InnFocus Inc., 12415 SW 136th Avenue #3, Miami, FL 33186, États-Unis.
authors.forename: L
authors.initials: L
authors.lastname: Pinchuk
authors.affiliation: InnFocus Inc., 12415 SW 136th Avenue #3, Miami, FL 33186, États-Unis.
authors.forename: Y P
authors.initials: YP
authors.lastname: Kato
authors.affiliation: InnFocus Inc., 12415 SW 136th Avenue #3, Miami, FL 33186, États-Unis.
authors.forename: B A
authors.initials: BA
authors.lastname: Weber
authors.affiliation: Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, États-Unis.
authors.forename: J-M
authors.initials: JM
authors.lastname: Parel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018463:Filtering Surgery / Q000295:instrumentation; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D012189:Retrospective Studies; D013997:Time Factors; D014065:Tonometry, Ocular; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D016685:Mitomycin
keywords: Chirurgie du glaucome; Chirurgie filtrante; Chirurgie mini-invasive du glaucome; Filtering surgery; Glaucoma surgery; MicroShunt(®); Minimally invasive surgery for glaucoma