title: Synthesis of diverse pyrazole-4-sulfonyl chlorides starting from 2-(benzylthio)malonaldehyde.
abstract: A series of pyrazole-4-sulfonyl chlorides was obtained by a convenient 2-step method starting from synthetically available 2-(benzylthio)malonaldehyde. The method can be applied for the effective multi-gram synthesis of diverse pyrazole-containing sulfonyl chlorides which are mostly not available by other methods.
authors.affiliation: Kyiv National Taras Shevchenko University, 64 Volodymirska st., Kyiv, 33, 01033, Ukraine.|Enamine Ltd., 23 A. Matrosova st., Kyiv, 01103, Ukraine.
authors.forename: Pavlo A
authors.initials: PA
authors.lastname: Sokolyuk
authors.affiliation: Enamine Ltd., 23 A. Matrosova st., Kyiv, 01103, Ukraine. kondratov@mail.enamine.net.|Institute of Bioorganic Chemistry and Petrochemistry, National Ukrainian Academy of Science, Murmanska 1, Kyiv, 94, 02660, Ukraine. kondratov@mail.enamine.net.
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Kondratov
authors.affiliation: Kyiv National Taras Shevchenko University, 64 Volodymirska st., Kyiv, 33, 01033, Ukraine.|Enamine Ltd., 23 A. Matrosova st., Kyiv, 01103, Ukraine.
authors.forename: Olexiy V
authors.initials: OV
authors.lastname: Gavrylenko
authors.affiliation: Kyiv National Taras Shevchenko University, 64 Volodymirska st., Kyiv, 33, 01033, Ukraine.|Enamine Ltd., 23 A. Matrosova st., Kyiv, 01103, Ukraine.
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Tolmachov
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry; D002712:Chlorides / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D008315:Malondialdehyde / Q000737:chemistry*; D015394:Molecular Structure; D013441:Sulfinic Acids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001593:Benzyl Compounds; D002712:Chlorides; D013441:Sulfinic Acids; D008315:Malondialdehyde
keywords: Chlorination; Cyclization; Heterocycles; Hydrazines; Oxidation; Pyrazole; Sulfonamides; Sulfonyl chlorides