title: SeDuS: segmental duplication simulator.
abstract: CONCLUSIONS
  SeDuS is the first flexible and user-friendly forward-in-time simulator of patterns of molecular evolution within segmental duplications undergoing interlocus gene conversion and crossover. SeDuS introduces known features of interlocus gene conversion such as biased directionality and dependence on local sequence identity. Additionally, it includes aspects such as different selective pressures acting upon copy number and flexible crossover distributions. A graphical user interface allows fast fine-tuning of relevant parameters and straightforward real-time analysis of the evolution of duplicates.
  
  
  METHODS
  SeDuS is implemented in C++ and can be run via command line or through a graphical user interface developed using Qt C++. Source code and binary executables for Linux, OS X and Windows are freely available at www.biologiaevolutiva.org/sedus/. A tutorial with a detailed description of implementation, parameters and output files is available online.
  
  
  BACKGROUND
  arcadi.navarro@upf.edu.
authors.affiliation: Institute of Evolutionary Biology (Universitat Pompeu Fabra - CSIC), PRBB, 08003.
authors.forename: Diego A
authors.initials: DA
authors.lastname: Hartasánchez
authors.affiliation: Institute of Evolutionary Biology (Universitat Pompeu Fabra - CSIC), PRBB, 08003.
authors.forename: Marina
authors.initials: M
authors.lastname: Brasó-Vives
authors.affiliation: Institute of Evolutionary Biology (Universitat Pompeu Fabra - CSIC), PRBB, 08003.
authors.forename: Juanma
authors.initials: J
authors.lastname: Fuentes-Díaz
authors.affiliation: Institute of Evolutionary Biology (Universitat Pompeu Fabra - CSIC), PRBB, 08003.
authors.forename: Oriol
authors.initials: O
authors.lastname: Vallès-Codina
authors.affiliation: Institute of Evolutionary Biology (Universitat Pompeu Fabra - CSIC), PRBB, 08003, National Institute for Bioinformatics, 08003, Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 and Centre for Genomic Regulation (CRG), 08003, Barcelona, Spain.
authors.forename: Arcadi
authors.initials: A
authors.lastname: Navarro
mesh_terms: D019143:Evolution, Molecular; D005785:Gene Conversion; D006801:Humans; D011381:Programming Languages; D056916:Segmental Duplications, Genomic; D012984:Software