title: Fabrication and Characterization of Poly(lactic acid)/Poly(ε-caprolactone) Blend Electrospun Fibers Loaded with Amoxicillin for Tunable Delivering.
abstract: Blends of poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL), loaded with different amounts of Amoxicillin antibiotic (AMOX) were electrospun to investigate their release properties and obtain a controlled and tuneable release. The processing parameters for electrospinning were set up and reliable membranes were obtained. Morphology and thermal behaviour were found dependent on the component ratio as well as on the incorporated drug amount. A very different release kinetics of the two pristine polymers, very rapid for PCL and very slow for PLA, reflected in intermediate release time. However comparing the release amount with that predicted by the mixture rule a preferential incorporation of AMOX into PLA can be inferred.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Valarezo
authors.forename: Loredana
authors.initials: L
authors.lastname: Tammaro
authors.forename: Omar
authors.initials: O
authors.lastname: Malagón
authors.forename: Silvia
authors.initials: S
authors.lastname: González
authors.forename: Chabaco
authors.initials: C
authors.lastname: Armijos
authors.forename: Vittoria
authors.initials: V
authors.lastname: Vittoria
mesh_terms: D000658:Amoxicillin / Q000737:chemistry / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D019344:Lactic Acid; C033616:poly(lactide); D000658:Amoxicillin