title: Selectins in Liver Ischemia and Reperfusion Injury.
abstract: Liver ischemia reperfusion injury is mediated by a complex system of signaling cascades and inflammatory response resulting in organ damage. Selectins are a group of cell adhesion glycoproteins that play a key role in the initial immunological response. L-selectins, found on leukocytes, initiate the original adhesion and rolling phase of leukocyte extravasation upon liver sinusoidal endothelial cells (LSECs). P-selectins, found on platelets and tissue-specific endothelial cells, further increases leukocyte-endothelial adhesion and rolling. P-selectin-ligand binding also initiates intracellular signals that produce adhesion molecules to start firm adhesion and increase local chemokine production. L-selectin-ligand binding on the leukocytes increases adhesion molecule expression and chemokines, but also initiate changes in intracellular structural actin. E-selectin expression occurs with the presence of TNF-α and/or IL-1β. E-selectin-ligand binding decreases leukocyte rolling velocity and increases adhesion molecules. Together, these glycoproteins transition the leukocyte response from original margination and rolling to firm adhesion and eventually migration.
authors.affiliation: a Michigan State University, College of Osteopathic Medicine , East Lansing , Michigan , USA.
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Jones
authors.affiliation: b Western Michigan University Homer Stryker MD School of Medicine, Departments of Research and Surgery , Kalamazoo , Michigan , USA.
authors.forename: Luis H
authors.initials: LH
authors.lastname: Toledo-Pereyra
authors.affiliation: c Western Michigan University Homer Stryker MD School of Medicine, Department of Biomedical Sciences , Kalamazoo , Michigan , USA.
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Quesnelle
mesh_terms: D000818:Animals; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism* / Q000517:prevention & control; D015427:Reperfusion Injury / Q000378:metabolism* / Q000517:prevention & control; D019087:Selectins / Q000378:metabolism*
chemical_list: D019087:Selectins
keywords: IR; e-selectin; ischemia reperfusion; l-selectin; liver; p-selectin; selectins