title: FDG PET/CT in Early and Late Stages of SAPHO Syndrome: Two Case Reports With MRI and Bone Scintigraphy Correlation.
abstract: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare disease, which may be underdiagnosed or misdiagnosed because of nonspecific clinical and imaging findings. We present 2 cases of SAPHO syndrome with MRI, bone scintigraphy, and FDG PET/CT findings. In case 1 with early-stage disease, the active osteitis showed osteolytic bone destruction with increased FDG uptake. In case 2 with late-stage disease, the inactive bone lesions presented as osteosclerosis with normal FDG uptake. Familiarity with the FDG PET/CT findings of SAPHO syndrome in different stages may be helpful for correct diagnosis.
authors.affiliation: From the Departments of *Nuclear Medicine and †Orthopaedic Surgery, Changhai Hospital, Second Military Medical University, Shanghai; ‡Department of Cardiothoracic Surgery, Lvcheng Hospital, Hangzhou, Zhejiang Province, China.
authors.forename: Aisheng
authors.initials: A
authors.lastname: Dong
authors.forename: Yushu
authors.initials: Y
authors.lastname: Bai
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Changjing
authors.initials: C
authors.lastname: Zuo
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18