title: Asthma and asthma medication use among 4-year-old offspring of subfertile couples--association with IVF?
abstract: This study evaluated the prevalence of asthma and asthma medication use in 213 4-year-old singletons followed from birth onwards, including three groups of children born following: (i) controlled ovarian hyperstimulation IVF/intracytoplasmic sperm injection (ICSI); (ii) modified natural cycle IVF/ICSI; and (iii) natural conception in subfertile couples. The rate of asthma medication was higher in the ovarian hyperstimulation-IVF/ICSI than in the subfertile group (adjusted odds ratios [aOR]: 1.96 [1.00-3.84]). Time to pregnancy, a proxy for the severity of subfertility, was not associated with asthma and asthma medication. In conclusion, controlled ovarian hyperstimulation-IVF/ICSI is associated with the use of asthma medication in 4-year-old offspring of subfertile couples.
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Paediatrics, Division of Developmental Neurology, Groningen, The Netherlands.
authors.forename: Derk B
authors.initials: DB
authors.lastname: Kuiper
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Paediatrics, Division of Developmental Neurology, Groningen, The Netherlands.
authors.forename: Jorien
authors.initials: J
authors.lastname: Seggers
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Paediatrics, Division of Developmental Neurology, Groningen, The Netherlands.
authors.forename: Pamela
authors.initials: P
authors.lastname: Schendelaar
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Genetics, Division of Clinical Genetics, Groningen, The Netherlands.
authors.forename: Maaike L
authors.initials: ML
authors.lastname: Haadsma
authors.affiliation: University of Amsterdam, Academic Medical Center, Department of Obstetrics and Gynaecology, Amsterdam, The Netherlands; University of Amsterdam, Academic Medical Center, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam, The Netherlands.
authors.forename: Tessa J
authors.initials: TJ
authors.lastname: Roseboom
authors.affiliation: University of Amsterdam, Academic Medical Center, Department of Obstetrics and Gynaecology, Amsterdam, The Netherlands.
authors.forename: Maas J
authors.initials: MJ
authors.lastname: Heineman
authors.affiliation: University of Groningen, University Medical Center Groningen, Department of Paediatrics, Division of Developmental Neurology, Groningen, The Netherlands. Electronic address: m.hadders-algra@umcg.nl.
authors.forename: Mijna
authors.initials: M
authors.lastname: Hadders-Algra
mesh_terms: D000328:Adult; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D016241:Child of Impaired Parents; D002675:Child, Preschool; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D007246:Infertility / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D015995:Prevalence
chemical_list: D018927:Anti-Asthmatic Agents
keywords: assisted reproductive techniques; asthma; asthma medication; in-vitro fertilization; time to pregnancy