title: Influence of acute glycaemic level on measures of myocardial infarction in non-diabetic pigs.
abstract: OBJECTIVE
  Patients with diabetes are at increased risk of experiencing myocardial infarction. The influence of the prevailing plasma glucose level on infarction and mortality after acute ischaemia is however unknown. The aim was to study the effect of the acute plasma glucose level on the myocardial infarction size in a closed-chest pig model.
  
  
  METHODS
  38 non-diabetic pigs were randomised to hypoglycaemic (1.8-2.2 mmol/l; n = 15), normoglycaemic (5-7 mmol/l; n = 12) or hyperglycaemic glucose clamping (22-23 mmol/l; n = 11). After 30 min within glucose target myocardial infarction was induced for 30 min followed by reperfusion for 120 min. Hereafter the heart was double-stained to delineate infarction from viable tissue within the area at risk.
  
  
  RESULTS
  Mean infarction size was 201 ± 35 mm(2) (mean ± SEM) in the hypoglycaemic group, 154 ± 40 mm(2) in the normoglycaemic group and 134 ± 40 mm(2) in the hyperglycaemic group, with no differences in infarction size, infarct/area at risk ratio or troponin T levels between the groups. There was no difference in incidence of ventricular fibrillation or mortality between the groups.
  
  
  CONCLUSIONS
  No statistically significant associations were observed between the acute glycaemic level and measures of myocardial infarction, rates of ventricular fibrillation and subsequent premature death in the setting of acute ischaemia and reperfusion.
authors.affiliation: a Department of Cardiology , Nephrology and Endocrinology, Nordsjællands Hospital , Hillerød , Denmark.|b Faculty of Health and Medical Sciences, University of Copenhagen , Denmark.
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Diemar
authors.affiliation: a Department of Cardiology , Nephrology and Endocrinology, Nordsjællands Hospital , Hillerød , Denmark.|c Faculty of Health Sciences, University of Southern Denmark.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Sejling
authors.affiliation: d Department of Cardiology , Herlev Hospital , Herlev.
authors.forename: Kasper K
authors.initials: KK
authors.lastname: Iversen
authors.affiliation: e Department of Cardiology , Rigshospitalet , Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Engstrøm
authors.affiliation: f Department of Cardiothoracic and Vascular Surgery , Aarhus University Hospital , Skejby , Denmark.
authors.forename: Jesper L
authors.initials: JL
authors.lastname: Honge
authors.affiliation: a Department of Cardiology , Nephrology and Endocrinology, Nordsjællands Hospital , Hillerød , Denmark.
authors.forename: Niels
authors.initials: N
authors.lastname: Tønder
authors.affiliation: d Department of Cardiology , Herlev Hospital , Herlev.
authors.forename: Niels
authors.initials: N
authors.lastname: Vejlstrup
authors.affiliation: g Center for Cancer Immune Therapy, Department of Hematology , Herlev Hospital , Denmark.
authors.forename: Manja
authors.initials: M
authors.lastname: Idorn
authors.affiliation: a Department of Cardiology , Nephrology and Endocrinology, Nordsjællands Hospital , Hillerød , Denmark.|b Faculty of Health and Medical Sciences, University of Copenhagen , Denmark.
authors.forename: Kathrine
authors.initials: K
authors.lastname: Ekström
authors.affiliation: a Department of Cardiology , Nephrology and Endocrinology, Nordsjællands Hospital , Hillerød , Denmark.|b Faculty of Health and Medical Sciences, University of Copenhagen , Denmark.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Pedersen-Bjergaard
authors.affiliation: a Department of Cardiology , Nephrology and Endocrinology, Nordsjællands Hospital , Hillerød , Denmark.|b Faculty of Health and Medical Sciences, University of Copenhagen , Denmark.
authors.forename: Birger
authors.initials: B
authors.lastname: Thorsteinsson
authors.affiliation: d Department of Cardiology , Herlev Hospital , Herlev.
authors.forename: Morten
authors.initials: M
authors.lastname: Dalsgaard
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006943:Hyperglycemia / Q000097:blood* / Q000473:pathology; D007003:Hypoglycemia / Q000097:blood* / Q000473:pathology; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D012307:Risk Factors; D013552:Swine; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000097:blood / Q000473:pathology / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: Cardiovascular disease; Coronary Artery Disease; Diabetes Mellitus; Hypoglycaemia; Myocardial infarction