title: Association of Lifestyle-Related Comorbidities With Periodontitis: A Nationwide Cohort Study in Korea.
abstract: The aim of this study was to determine the association of periodontitis with lifestyle-related comorbidities (LCs) using data in the Korean National Health Insurance Cohort Database from 2002 to 2013. This was a retrospective study involving a large national cohort with patient samples (representing 2% of the total Korean population) stratified on the basis of sociodemographic information. Using this precisely extracted database, the correlations between LCs (cerebral infarction, angina pectoris, myocardial infarction, hypertension, diabetes mellitus, rheumatoid arthritis, erectile dysfunction, osteoporosis, and obesity) and periodontitis were investigated while adjusting for confounding bias. Univariate and multiple logistic regression analyses were used to evaluate differences in variable factors. Among a total of 1,025,340 samples, 321,103 (31.3%) cases were diagnosed with periodontitis. Statistically significant associations were found between all LCs except myocardial infarction and periodontitis (P < 0.005). Periodontitis is significantly and positively correlated with LCs (except for myocardial infarction) after adjusting for confounding bias. In particular, lifestyle-related diseases, erectile dysfunction, and osteoporosis seem to be intimately related to periodontitis.
authors.affiliation: From the Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul (J-HL, J-SL, J-YP, S-HC); Department of Health Insurance Research (J-KC); Department of Policy Research Affairs (D-WK); and Department of Periodontology, Ilsan Hospital, National Health Insurance Service, Goyang, Korea (Y-TK).
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Lee
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Park
authors.forename: Jung-Kyu
authors.initials: JK
authors.lastname: Choi
authors.forename: Dong-Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Young-Taek
authors.initials: YT
authors.lastname: Kim
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000453:epidemiology*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D055815:Young Adult