title: Nanoencapsulation of Rose-Hip Oil Prevents Oil Oxidation and Allows Obtainment of Gel and Film Topical Formulations.
abstract: The rose-hip oil holds skin regenerating properties with applications in the dermatological and cosmetic area. Its nanoencapsulation might favor the oil stability and its incorporation into hydrophilic formulations, besides increasing the contact with the skin and prolonging its effect. The aim of the present investigation was to develop suitable rose-hip-oil-loaded nanocapsules, to verify the nanocapsule effect on the UV-induced oxidation of the oil and to obtain topical formulations by the incorporation of the nanocapsules into chitosan gel and film. The rose-hip oil (500 or 600 μL), polymer (Eudragit RS100®, 100 or 200 mg), and acetone (50 or 100 mL) contents were separately varied aiming to obtain an adequate size distribution. The results led to a combination of the factors acetone and oil. The developed formulation showed average diameter of 158 ± 6 nm with low polydispersity, pH of 5.8 ± 0.9, zeta potential of +9.8 ± 1.5 mV, rose-hip oil content of 54 ± 1 μL/mL and tendency to reversible creaming. No differences were observed in the nanocapsules properties after storage. The nanoencapsulation of rose-hip oil decreased the UVA and UVC oxidation of the oil. The chitosan gel and film containing rose-hip-oil-loaded nanocapsules showed suitable properties for cutaneous use. In conclusion, it was possible to successfully obtain rose-hip-oil-loaded nanocapsules and to confirm the nanocapsules effect in protecting the oil from the UV rays. The chitosan gel and film were considered interesting alternatives for incorporating the nanoencapsulated rose-hip oil, combining the advantages of the nanoparticles to the advantages of chitosan.
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752/405, CEP 90610-000, Porto Alegre, RS, Brazil. renata.contri@gmail.com.
authors.forename: Renata V
authors.initials: RV
authors.lastname: Contri
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752/405, CEP 90610-000, Porto Alegre, RS, Brazil.|Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Irene C
authors.initials: IC
authors.lastname: Kulkamp-Guerreiro
authors.affiliation: Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Sheila Janine
authors.initials: SJ
authors.lastname: da Silva
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752/405, CEP 90610-000, Porto Alegre, RS, Brazil.
authors.forename: Luiza A
authors.initials: LA
authors.lastname: Frank
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752/405, CEP 90610-000, Porto Alegre, RS, Brazil.|Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Adriana R
authors.initials: AR
authors.lastname: Pohlmann
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752/405, CEP 90610-000, Porto Alegre, RS, Brazil.|Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Silvia S
authors.initials: SS
authors.lastname: Guterres
mesh_terms: D000096:Acetone / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry; D000287:Administration, Topical; D002626:Chemistry, Pharmaceutical / Q000379:methods; D048271:Chitosan / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D027826:Rosa / Q000737:chemistry*; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D000180:Acrylic Resins; D020100:Hydrogels; D053769:Nanocapsules; D010938:Plant Oils; D011108:Polymers; D000096:Acetone; C050528:Eudragit RS; D048271:Chitosan
keywords: UV-induced oxidation; chitosan film; chitosan gel; polymeric nanocapsules; rose-hip oil