title: Analysis of 25I-NBOMe, 25B-NBOMe, 25C-NBOMe and Other Dimethoxyphenyl-N-[(2-Methoxyphenyl) Methyl]Ethanamine Derivatives on Blotter Paper.
abstract: In recent years, N-methoxybenzyl-methoxyphenylethylamine (NBOMe) derivatives, a class of designer hallucinogenic drugs, have become popular drugs of abuse. These drugs have been the cause of severe intoxications and even deaths. They act as 5-HT2A receptors agonists and have been reported to produce serotonin-like syndrome with bizarre behavior, severe agitation and seizures persisting for as long as 3 days. The most commonly reported derivatives are 25I-NBOMe, 25B-NBOMe and 25C-NBOMe, respectively 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl]ethanamine, N-(2-methoxybenzyl)-2,5-dimethoxy-4-bromophenethylamine and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine. Like many low dose hallucinogenic drugs these compounds are often sold on blotter paper. Three different types of commercially available blotter papers reported to contain NBOMe derivatives were obtained. These blotter papers were screened using Direct Analysis in Real Time AccuTOF(TM) mass spectrometry followed by confirmation and quantification by high-performance liquid chromatography triple quadrapole mass spectrometry. The major drug present on each of the three blotter products was different, 25I-NBOMe, 25C-NBOMe or 25B-NBOMe. The blotter papers were also found to have minute amounts of two or three NBOMe derivative impurities of 25H-NBOMe, 25I-NBOMe, 25C-NBOMe, 25B-NBOMe and/or 25D-NBOMe.
authors.affiliation: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Justin L
authors.initials: JL
authors.lastname: Poklis
authors.affiliation: Department of Forensic Science, Virginia Commonwealth University, PO Box 843079, 1015 Floyd Avenue, Room 2015, Richmond 23284, VA, USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Raso
authors.affiliation: Department of Forensic Science, Virginia Commonwealth University, PO Box 843079, 1015 Floyd Avenue, Room 2015, Richmond 23284, VA, USA.
authors.forename: Kylie N
authors.initials: KN
authors.lastname: Alford
authors.affiliation: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA Department of Forensic Science, Virginia Commonwealth University, PO Box 843079, 1015 Floyd Avenue, Room 2015, Richmond 23284, VA, USA Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Alphonse
authors.initials: A
authors.lastname: Poklis
authors.affiliation: Department of Forensic Science, Virginia Commonwealth University, PO Box 843079, 1015 Floyd Avenue, Room 2015, Richmond 23284, VA, USA mrpeace@vcu.edu.
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Peace
mesh_terms: D000840:Anisoles / Q000032:analysis*; D001596:Benzylamines / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004118:Dimethoxyphenylethylamine / Q000031:analogs & derivatives* / Q000032:analysis; D010627:Phenethylamines / Q000032:analysis*; D053719:Tandem Mass Spectrometry
chemical_list: D000840:Anisoles; D001596:Benzylamines; D004118:Dimethoxyphenylethylamine; D010627:Phenethylamines; C554181:2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine; C000601106:2-(4-chloro-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine; C000595926:2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine