title: Functional Impact of Autophagy-Related Genes on the Homeostasis and Dynamics of Pancreatic Cancer Cell Lines.
abstract: Pancreatic cancer is a highly aggressive and chemotherapy-resistant malignant neoplasm. In basal condition, it is characterized by elevated autophagy activity, which is required for tumor growth and that correlates with treatment failure. We analyzed the expression of autophagy related genes in different pancreatic cancer cell lines. A correlation-based network analysis evidenced the sociality and topological roles of the autophagy-related genes after serum starvation. Structural and functional tests identified a core set of autophagy related genes, suggesting different scenarios of autophagic responses to starvation, which may be responsible for the clinical variations associated with pancreatic cancer pathogenesis.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Mazza
authors.forename: Caterina
authors.initials: C
authors.lastname: Fusilli
authors.forename: Chiara
authors.initials: C
authors.lastname: Saracino
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Mazzoccoli
authors.forename: Francesca
authors.initials: F
authors.lastname: Tavano
authors.forename: Manlio
authors.initials: M
authors.lastname: Vinciguerra
authors.forename: Valerio
authors.initials: V
authors.lastname: Pazienza
mesh_terms: D001343:Autophagy / Q000235:genetics*; D045744:Cell Line, Tumor; D016000:Cluster Analysis; D019295:Computational Biology; D020869:Gene Expression Profiling; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics*