title: Disease recognition is related to specific autobiographical memory deficits in alcohol-dependence.
abstract: The particularly high treatment gap in alcohol-dependence suggests the existence of important barriers to treatment decision and in particular difficulties in problem recognition. This study tested the relation between problem recognition and self-related memories. Forty-one recently detoxified alcohol-dependent individuals (AD) were compared to twenty alcoholic subjects that were abstinent for 6 months or more (recruited among alcoholics-anonymous (AA)), and to twenty controls on autobiographical memories elicited by pictures depicting or not alcohol using the autobiographical memory test. Autonoetic consciousness was measured with the Remember/Know paradigm. We tested whether memories performances were related with data obtained on the readiness to change questionnaire (RCQ) or with consciousness of the severity of drinking. AD subjects provided less specific memories than control and AA subjects, and fewer Remember responses than controls. The deficits in AD subjects were not specific for memories elicited by pictures depicting alcohol, suggesting a global deficit. Autobiographical memories specificity was negatively correlated to scores of consciousness of the severity of drinking but not to RCQ. Our results support potential recovery of autobiographical memory with abstinence. AD's deficits in autobiographical memory were related to capacities to recognize the severity and therefore may be a barrier to treatment decision.
authors.affiliation: Laboratory for Experimental Psychopathology, Psychological Sciences Research Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium; Psychological Sciences Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Marie
authors.initials: M
authors.lastname: Poncin
authors.affiliation: Department of Adult Psychiatry, Hôpital universitaire Saint-Luc, Brussels, Belgium.
authors.forename: Aurore
authors.initials: A
authors.lastname: Neumann
authors.affiliation: Psychological Sciences Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; The Belgian Fund for Scientific Research (FRS-FNRS), Brussels, Belgium.
authors.forename: Olivier
authors.initials: O
authors.lastname: Luminet
authors.affiliation: Psychological Sciences Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Department of Adult Psychiatry, Hôpital universitaire Saint-Luc, Brussels, Belgium.
authors.forename: Noémie
authors.initials: N
authors.lastname: Vande Weghe
authors.affiliation: Laboratory for Experimental Psychopathology, Psychological Sciences Research Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium; Psychological Sciences Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Philippot
authors.affiliation: Laboratory for Experimental Psychopathology, Psychological Sciences Research Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium; Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium; Department of Adult Psychiatry, Hôpital universitaire Saint-Luc, Brussels, Belgium. Electronic address: philippe.detimary@uclouvain.be.
authors.forename: Philippe
authors.initials: P
authors.lastname: de Timary
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000523:psychology; D000437:Alcoholism / Q000188:drug therapy* / Q000523:psychology*; D003243:Consciousness; D059026:Diagnostic Self Evaluation; D005260:Female; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D021641:Recognition, Psychology
keywords: Alcohol-dependence; Anosognosia; Cognition; Denial; Disease consciousness