title: Current strategies for sustaining drug release from electrospun nanofibers.
abstract: Electrospun drug-eluting fibers are emerging as a novel dosage form for multipurpose prevention against sexually transmitted infections, including HIV, and unintended pregnancy. Previous work from our lab and others show the versatility of this platform to deliver large doses of physico-chemically diverse agents. However, there is still an unmet need to develop practical fiber formulations for water-soluble small molecule drugs needed at high dosing due to intrinsic low potency or desire for sustained prevention. To date, most sustained release fibers have been restricted to the delivery of biologics or hydrophobic small molecules at low drug loading of typically <1 wt.%, which is often impractical for most clinical applications. For hydrophilic small molecule drugs, their high aqueous solubility and poor partitioning and incompatibility with insoluble polymers make long-term release even more challenging. Here we investigate several existing strategies to sustain release of hydrophilic small molecule drugs that are highly-loaded in electrospun fibers. In particular, we investigate what is known about the design constraints required to realize multi-day release from fibers fabricated from uniaxial and coaxial electrospinning.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle WA 98195-5061, USA.
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Chou
authors.affiliation: Department of Bioengineering, University of Washington, Seattle WA 98195-5061, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Carson
authors.affiliation: Department of Bioengineering, University of Washington, Seattle WA 98195-5061, USA. Electronic address: woodrow@uw.edu.
authors.forename: Kim A
authors.initials: KA
authors.lastname: Woodrow
mesh_terms: D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D057139:Nanofibers; D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: Coaxial; Drug delivery; Electrospun fibers; Sustained release; Uniaxial