title: Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis.
abstract: Tumor progression is classically viewed as the Darwinian evolution of subclones that sequentially acquire genetic mutations and autonomously overproliferate. However, growing evidence suggests that tumor microenvironment and subclone heterogeneity contribute to non-autonomous tumor progression. Recent Drosophila studies revealed a common mechanism by which clones of genetically altered cells trigger non-autonomous overgrowth. Such "oncogenic niche cells" (ONCs) do not overgrow but instead stimulate neighbor overgrowth and metastasis. Establishment of ONCs depends on competition and cooperation between heterogeneous cell populations. This review characterizes diverse ONCs identified in Drosophila and describes the genetic basis of non-autonomous tumor progression. Similar mechanisms may contribute to mammalian cancer progression and recurrence.
authors.affiliation: Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Enomoto
authors.affiliation: Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
authors.forename: John
authors.initials: J
authors.lastname: Vaughen
authors.affiliation: Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.|PRESTO, Japan Science and Technology Agency, Saitama, Japan.
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Igaki
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000473:pathology*; D004330:Drosophila; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000473:pathology*; D059016:Tumor Microenvironment / Q000502:physiology*
keywords: Cell competition; cell death; cellular cooperation; cellular senescence; tumor progression