title: [Comorbidity of depressive disorders and coronary heart disease: general aspects of pathogenesis].
abstract: OBJECTIVE
  The high level of comorbidity of coronary heart disease (CHD) and depressive disorders and general aspects of their pathogenesis is an actual problem of modern research. Authors studied the content of cholesterol, platelet serotonin, platelet aggregation, activity of pro-inflammatory markers in CHD patients with comorbid depressive disorders.
  
  
  METHODS
  The study included 76 patients with CAD. The diagnosis of depressive disorder was set according to ICD-10, The Hamilton depression scales was used.
  
  
  CONCLUSIONS
  Depressive disorders in CHD patients were associated with an increase in the activity of pro-inflammatory markers (IL-6 and TNF-α), and with high levels of low density lipoproteins. In patients with CAD and depressive disorders with high contents of platelet serotonin, the level of cholesterol was higher compared to those with low contents of serotonin. No significant differences in the functional platelet activity were identified in patients with CAD and comorbid depression compared to patients without mood disorders.
authors.affiliation: Bekhterev St. Petersburg Research Psychoneurological Institute, St. Petersburg; Pavlov First State Medical University, St. Petersburg.
authors.forename: N G
authors.initials: NG
authors.lastname: Neznanov
authors.affiliation: Almazov Federal Medical Science Centre, St. Petersburg.
authors.forename: S N
authors.initials: SN
authors.lastname: Kozlova
authors.affiliation: Bekhterev St. Petersburg Research Psychoneurological Institute, St. Petersburg; St. Petersburg State University, St. Petersburg.
authors.forename: G E
authors.initials: GE
authors.lastname: Mazo
authors.affiliation: Pavlov First State Medical University, St. Petersburg; Almazov Federal Medical Science Centre, St. Petersburg.
authors.forename: N G
authors.initials: NG
authors.lastname: Shlyakhto
authors.affiliation: Uliaynov (Lenin) State Electrotechnical University, St. Petersburg.
authors.forename: B I
authors.initials: BI
authors.lastname: Smirnov
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry / Q000502:physiology; D015897:Comorbidity; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology*; D003866:Depressive Disorder / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D012701:Serotonin / Q000097:blood
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL; D012701:Serotonin