title: Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry.
abstract: The impact of the development of sulfur therapeutics is instrumental to the evolution of the pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of pharmaceuticals and natural products. For centuries, sulfur continues to maintain its status as the dominating heteroatom integrated into a set of 362 sulfur-containing FDA approved drugs (besides oxygen or nitrogen) through the present. Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades. In this review, these four moieties in pharmaceuticals and recent advances in the synthesis of the corresponding core scaffolds are presented.
authors.forename: Minghao
authors.initials: M
authors.lastname: Feng
authors.forename: Bingqing
authors.initials: B
authors.lastname: Tang
authors.forename: Steven H
authors.initials: SH
authors.lastname: Liang
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P. R. China. xfjiang@chem.ecnu.edu.cn.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Jiang
mesh_terms: D002626:Chemistry, Pharmaceutical; D055808:Drug Discovery; D006801:Humans; D010406:Penicillins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013457:Sulfur Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D010406:Penicillins; D013440:Sulfides; D013449:Sulfonamides; D013450:Sulfones; D013457:Sulfur Compounds