title: Nickel-Catalyzed Regioselective Cross-Dehydrogenative Coupling of Inactive C(sp(3))-H Bonds with Indole Derivatives.
abstract: A nickel-catalyzed regiosepecific C2- versus C3-oxidative cross-coupling reaction of indoles with 1,4-dioxane and other inactive C(sp(3))-H bonds is described. The divergent synthesis of C(sp(3))-C(sp(2)) bonds was achieved in satisfactory yields with di-tert-butyl peroxide (DTBP) as the oxidant, which provides an efficient strategy for the selective construction of cyclic ethers containing heteroaromatic core structures.
authors.affiliation: Chemical Engineering College, Nanjing University of Science and Technology , Nanjing 210094, People's Republic of China.
authors.forename: Li-Kun
authors.initials: LK
authors.lastname: Jin
authors.affiliation: Biotechnology and Pharmaceutical Engineering College, Nanjing Tech University , Nanjing 211816, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Wan
authors.affiliation: Chemical Engineering College, Nanjing University of Science and Technology , Nanjing 210094, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
authors.affiliation: Chemical Engineering College, Nanjing University of Science and Technology , Nanjing 210094, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Cai