title: Uric Acid and the Risk of Alzheimer's Disease: Is There an Association?
abstract: Alzheimer's disease (AD) is a very common neurodegenerative disorder of the central nervous system, characterized by dementia, cognitive impairment, and memory loss, and the global prevalence is increasing. Many epidemiologic studies have considered the association between uric acid and AD, yet the relationship remains elusive. The objective of this study was to validate whether or not uric acid is indeed associated with AD. We compared different prospective studies and ultimately found that it is also a controversial issue. Further higher quality prospective evidence on the relationship between uric acid and AD in different age stage are needed to determine the causal association and its exact pathogenetic mechanisms.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yuan
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China xiaopingbuxiao@126.com xulijun20050901@sina.com.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Alzheimer’s disease; neurodegenerative disorder; oxidative stress; uric acid