title: Symptoms, signs, and tests: The general practitioner's comprehensive approach towards a cancer diagnosis.
abstract: OBJECTIVE
  To study the relative importance of different tools a GP can use during the diagnostic process towards cancer detection.
  
  
  METHODS
  Retrospective cohort study with prospective registration of cancer in general practice.
  
  
  METHODS
  One hundred and fifty-seven Norwegian general practitioners (GPs) reported 261 cancer patients.
  
  
  METHODS
  During 10 consecutive days, GPs registered all patient consultations and recorded any presence of seven focal symptoms and three general symptoms, commonly considered as warning signs of cancer (WSC). Follow-up was done six to 11 months later. For each patient with new or recurrent cancer, the GP completed a questionnaire with medical-record-based information concerning the diagnostic procedure.
  
  
  RESULTS
  In 78% of cancer cases, symptoms, signs, or tests helped diagnose cancer. In 90 cases, there were 131 consultation-recorded WSC that seemed related to the cancer. Further symptoms were reported for another 74 cases. Different clinical signs were noted in 41 patients, 16 of whom had no previous recording of symptoms. Supplementary tests added information in 59 cases; in 25 of these there were no recordings of symptoms or signs. Sensitivity of any cancer-relevant symptom or clinical finding ranged from 100% for patients with uterine body cancer to 57% for patients with renal cancer.
  
  
  CONCLUSIONS
  WSC had a major role as initiator of a cancer diagnostic procedure. Low-risk-but-not-no-risk symptoms also played an important role, and in 7% of patients they were the only symptoms. Clinical findings and/or supplementary procedures were sometimes decisive for rapid referral.
authors.affiliation: a Department of Community Medicine , UiT The Arctic University of Norway , Tromsø , Norway.
authors.forename: Benedicte Iversen
authors.initials: BI
authors.lastname: Scheel
authors.affiliation: a Department of Community Medicine , UiT The Arctic University of Norway , Tromsø , Norway.
authors.forename: Knut
authors.initials: K
authors.lastname: Holtedahl
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005194:Family Practice; D058006:General Practice; D058005:General Practitioners; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000175:diagnosis*; D009664:Norway; D010818:Practice Patterns, Physicians'; D012017:Referral and Consultation; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
keywords: Early detection of cancer; Norway; early diagnosis; family practice; general practice; neoplasms; pathological conditions; signs and symptoms