title: Hypothyroidism Enhanced Portal Hypertension in a Patient with Alcoholic Liver Cirrhosis, Resulting in the Development of Ascites.
abstract: A man diagnosed with alcoholic liver cirrhosis complained of abdominal distention due to massive ascites. The ascites did not resolve with diuretic agents. The serum-ascites albumin gradient value of 1.9 g/dL and the total protein level in the ascites of 3.1 g/dL indicated the ascites to have been caused by portal hypertension. Hypothyroidism was detected, and the patient received supplementation with levothyroxine. The ascites dramatically decreased after supplementation with levothyroxine. We herein conclude that the ascites in the present case had thus been strongly influenced by portal hypertension, which was induced by liver dysfunction associated with liver cirrhosis and hypothyroidism.
authors.affiliation: Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kakisaka
authors.forename: Kei
authors.initials: K
authors.lastname: Endo
authors.forename: Akiko
authors.initials: A
authors.lastname: Suzuki
authors.forename: Sadanari
authors.initials: S
authors.lastname: Hayashi
authors.forename: Tamami
authors.initials: T
authors.lastname: Abe
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Oikawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Kei
authors.initials: K
authors.lastname: Sawara
authors.forename: Kinji
authors.initials: K
authors.lastname: Ishida
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Kuroda
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takikawa
mesh_terms: D000368:Aged; D001201:Ascites / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D004232:Diuretics / Q000008:administration & dosage*; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D007037:Hypothyroidism / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008111:Liver Function Tests; D008297:Male; D012709:Serum Albumin / Q000378:metabolism; D013974:Thyroxine / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D004232:Diuretics; D012709:Serum Albumin; D013974:Thyroxine