title: Associations between a patient-reported outcome (PRO) measure of sarcopenia and falls, functional status, and physical performance in older patients with cancer.
abstract: OBJECTIVE
  In older patients with cancer, we aimed to investigate associations between a patient-reported outcome measure for sarcopenia (SarcoPRO) and the Short Physical Performance Battery (SPPB), self-reported falls, and limitations in instrumental activities of daily living (IADLs).
  
  
  METHODS
  Assessments were conducted as part of the initial evaluation of older, often frail, patients with cancer seen in the Specialized Oncology Care and Research in the Elderly (SOCARE) clinic. Univariate associations were evaluated using Spearman's correlation and Wilcoxon sign ranked tests. Logistic regressions were used to identify associations of clinical factors and SarcoPRO scores or SPPB scores with falls and IADL limitations.
  
  
  RESULTS
  In total, 174 older patients with cancer were evaluated. A moderate correlation was found between the SarcoPRO and the SPPB (ρ=0.62). After adjusting for multiple clinical factors, neither the SarcoPRO nor the SPPB were associated with falls. In contrast, both higher SarcoPRO (i.e., worse) and lower SPPB (i.e., worse) scores were associated with limitations in IADLs (odds ratio for one unit change in predictor: SarcoPRO: 1.06, p<0.0001; SPPB: 0.71, p=0.003, respectively). Models using the SarcoPRO and SPPB explained similar amounts of variability in association with IADL limitations (AUC: 0.88 vs. 0.87, respectively).
  
  
  CONCLUSIONS
  The SarcoPRO was moderately associated with the SPPB, an objective measure of physical performance, and was associated with limitations in IADLs. Thus, older patients with cancer who present with IADL limitations should be screened for sarcopenia. The SarcoPRO shows promise as a measure for screening as well as outcome assessment for research on sarcopenia.
authors.affiliation: Department of Anesthesiology, University of Rochester, Box 601 Elmwood Ave, Rochester, NY 14642, USA. Electronic address: jennifer_gewandter@urmc.rochester.edu.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Gewandter
authors.affiliation: Section of Geriatrics and Palliative Medicine, University of Chicago, Chicago, IL 60637, USA.
authors.forename: William
authors.initials: W
authors.lastname: Dale
authors.affiliation: James Wilmot Cancer Institute, University of Rochester, Rochester, NY 14642, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Magnuson
authors.affiliation: Department of Public Health Sciences, University of Rochester, Rochester, NY 14642, USA.
authors.forename: Chintan
authors.initials: C
authors.lastname: Pandya
authors.affiliation: Department of Surgery, University of Rochester, Rochester, NY 14642, USA.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Heckler
authors.affiliation: James Wilmot Cancer Institute, University of Rochester, Rochester, NY 14642, USA.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Lemelman
authors.affiliation: Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
authors.forename: Breton
authors.initials: B
authors.lastname: Roussel
authors.affiliation: Northwestern University, Evanston, IL 60208, USA.
authors.forename: Rafa
authors.initials: R
authors.lastname: Ifthikhar
authors.affiliation: Department of Public Health Sciences, University of Rochester, Rochester, NY 14642, USA.
authors.forename: James
authors.initials: J
authors.lastname: Dolan
authors.affiliation: Departments Surgery and of Public Health Sciences, University of Rochester, Rochester, NY 14642, USA.
authors.forename: Katia
authors.initials: K
authors.lastname: Noyes
authors.affiliation: James Wilmot Cancer Institute, University of Rochester, Rochester, NY 14642, USA.
authors.forename: Supriya G
authors.initials: SG
authors.lastname: Mohile
mesh_terms: D000058:Accidental Falls; D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications*; D063868:Patient Outcome Assessment; D055948:Sarcopenia / Q000453:epidemiology* / Q000209:etiology*; D057566:Self Report
keywords: Falls; IADLs; Patient reported outcome measure; Sarcopenia