title: Melatonin Lulling Th17 Cells to Sleep.
abstract: In this issue, Farez et al. report that the circadian hormone melatonin, whose levels vary with seasonal changes in night length, shifts the immune response toward an anti-inflammatory state that may explain the seasonal variability of multiple sclerosis disease activity.
authors.affiliation: IMR Pathway Biology, Merck Research Laboratory, 901 California Avenue, Palo Alto, CA 94304, USA. Electronic address: jacob.lee@merck.com.
authors.forename: Jacob S
authors.initials: JS
authors.lastname: Lee
authors.affiliation: IMR Pathway Biology, Merck Research Laboratory, 901 California Avenue, Palo Alto, CA 94304, USA. Electronic address: daniel.cua@merck.com.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Cua
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology*
chemical_list: D008550:Melatonin