title: ICT: isotope correction toolbox.
abstract: CONCLUSIONS
  Isotope tracer experiments are an invaluable technique to analyze and study the metabolism of biological systems. However, isotope labeling experiments are often affected by naturally abundant isotopes especially in cases where mass spectrometric methods make use of derivatization. The correction of these additive interferences--in particular for complex isotopic systems--is numerically challenging and still an emerging field of research. When positional information is generated via collision-induced dissociation, even more complex calculations for isotopic interference correction are necessary. So far, no freely available tools can handle tandem mass spectrometry data. We present isotope correction toolbox, a program that corrects tandem mass isotopomer data from tandem mass spectrometry experiments. Isotope correction toolbox is written in the multi-platform programming language Perl and, therefore, can be used on all commonly available computer platforms.
  
  
  METHODS
  Source code and documentation can be freely obtained under the Artistic License or the GNU General Public License from: https://github.com/jungreuc/isotope_correction_toolbox/
  
  
  BACKGROUND
  {christian.jungreuthmayer@boku.ac.at,juergen.zanghellini@boku.ac.at}
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Austrian Centre of Industrial Biotechnology (ACIB), Vienna, Austria, Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria and.
authors.forename: Christian
authors.initials: C
authors.lastname: Jungreuthmayer
authors.affiliation: Austrian Centre of Industrial Biotechnology (ACIB), Vienna, Austria, Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Neubauer
authors.affiliation: Austrian Centre of Industrial Biotechnology (ACIB), Vienna, Austria, Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
authors.forename: Teresa
authors.initials: T
authors.lastname: Mairinger
authors.affiliation: Austrian Centre of Industrial Biotechnology (ACIB), Vienna, Austria, Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria and.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Zanghellini
authors.affiliation: Austrian Centre of Industrial Biotechnology (ACIB), Vienna, Austria, Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
authors.forename: Stephan
authors.initials: S
authors.lastname: Hann
mesh_terms: D000465:Algorithms; D006801:Humans; D007553:Isotope Labeling / Q000379:methods*; D011381:Programming Languages; D012984:Software