title: Effect of airway dynamics on the development of larynx cancer.
abstract: This study aimed to investigate and measure airway dynamics in anatomical regions where laryngeal cancer was most common in comparison to other regions of the larynx, thereby determining the effect of airway dynamics on the development of laryngeal cancer.
  
  
  
  Pulmonary function test airflow data and larynx anatomy measurement data obtained by three-dimensional computed tomography. A healthy male adult was modeled by simulation using the ANSYS program. Analysis of air flow rates, pressure, and force were also made.
  
  
  
  The supraglottic region average pressure was higher when compared to the subglottic region and clearly lower when compared to the glottic region. The subglottic had the lowest pressure and force levels. The glottic region was the first ranked location for laryngeal cancer; the supraglottic region was the second; and the frequency of laryngeal cancer was much lower in the subglottic region. Our data suggests that the high pressure and force contribute to an increased amount of contact and interaction between toxic particles and mucosa and to increased diffusion of the particles, leading to an increased carcinogenic effect and frequency of cancer.
  
  
  
  Laryngeal cancer was found more frequently in regions with an increased pressure and force stress and reduced air velocity, with a subsequent increase in penetration of the inhaled toxic agents. These findings demonstrate the importance of basic physical fluid mechanics in cancer pathogenesis.
  
  
  
  NA. Laryngoscope, 126:1136-1142, 2016.
authors.affiliation: Department of Chest Disease, Dicle University, Diyarbakir, Turkey.
authors.forename: Mahsuk
authors.initials: M
authors.lastname: Taylan
authors.affiliation: the Department of Mechanical Engineering, Dicle University, Diyarbakir, Turkey.
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Can
authors.affiliation: the Department of Radiology, Dicle University, Diyarbakir, Turkey.
authors.forename: Mehmet Guli
authors.initials: MG
authors.lastname: Cetincakmak
authors.affiliation: Department of Otolaryngology, Dicle University, Diyarbakir, Turkey.
authors.forename: Musa
authors.initials: M
authors.lastname: Ozbay
mesh_terms: D000328:Adult; D006801:Humans; D007822:Laryngeal Neoplasms / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008954:Models, Biological; D012129:Respiratory Function Tests; D012143:Respiratory Physiological Phenomena; D012906:Smoke / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
chemical_list: D012906:Smoke
keywords: Larynx cancer; airway dynamics; numerical analysis