title: Applications of Fluorodeoxyglucose PET/Computed Tomography in the Assessment and Prediction of Radiation Therapy-related Complications.
abstract: One of the most important aspects of cancer treatment is radiation therapy, which is used for a wide range of malignancies. However, this treatment modality has side effects that impose the patient to increased risks of mortality and morbidity. Total dose, fraction size, and duration of radiation therapy are among the factors contributing to toxicities. In recent decades, fluorodeoxyglucose (FDG)-PET/computed tomography (CT) has been extensively used for diagnosis, prognostication, response to treatment assessment, and management of cancers and is currently a standard modality for many cancers. This article discusses the role of PET/CT, and especially FDG-PET/CT, in radiotherapy complications.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Sina
authors.initials: S
authors.lastname: Houshmand
authors.affiliation: Department of Gastroenterology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Ben
authors.initials: B
authors.lastname: Boursi
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Department of Radiology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Salavati
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Simone
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: abass.alavi@uphs.upenn.edu.
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi
mesh_terms: D019788:Fluorodeoxyglucose F18; D064847:Multimodal Imaging / Q000379:methods; D058958:Organs at Risk / Q000528:radiation effects; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D019275:Radiopharmaceuticals; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Cancer; Complications; Fluorodeoxyglucose PET/Computed tomography; Radiation therapy