title: T2 signal intensity and volume abnormalities of hippocampal subregions in patients with amnestic mild cognitive impairment by magnetic resonance imaging.
abstract: BACKGROUND
  The volumetry of the hippocampal subregion may provide additional information in the early investigation of amnestic mild cognitive impairment (aMCI) and the T2 signal intensity (T2-SI) of the hippocampal subregion has not been well studied quantitatively by magnetic resonance imaging (MRI) in aMCI.
  
  
  METHODS
  Using combined MRI-based hippocampal volumetry and T2-SI at the levels of the whole hippocampus and hippocampal subregion, 18 patients with aMCI and 18 age-matched controls were investigated.
  
  
  RESULTS
  Significantly lower left whole hippocampal and hippocampal head volumes and higher T2-SI in the bilateral whole hippocampus and hippocampal head were shown, whereas atrophy of the right whole hippocampus and hippocampal subregion was not significant in aMCI. Additionally, correlations were found among the hippocampal volume, T2-SI and Mini-Mental State Examination (MMSE) scores for aMCI in the whole hippocampus and some hippocampal subregions and an almost perfect correlation was found between T2-SI of the left hippocampal head and MMSE scores regarding aMCI (r = -0.831, P = 0.000).
  
  
  CONCLUSIONS
  Abnormalities of the hippocampal volume and T2-SI were documented in aMCI, whereas T2-SI was implied to be more susceptible than the volume in the pathohistological progression in aMCI. Additionally, T2-SI in the left hippocampal head may be a potential biomarker to facilitate the early diagnosis of aMCI.
authors.affiliation: a Department of Radiology , The Affiliated BenQ Hospital of Nanjing Medical University , Nanjing , China.|b Department of Radiology , The Affiliated Yixing Hospital of Jiangsu University , Wuxi , China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Luo
authors.affiliation: b Department of Radiology , The Affiliated Yixing Hospital of Jiangsu University , Wuxi , China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Cao
authors.affiliation: c Department of Radiology , Yixing Second People's Hospital , Wuxi , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: b Department of Radiology , The Affiliated Yixing Hospital of Jiangsu University , Wuxi , China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Wu
authors.affiliation: b Department of Radiology , The Affiliated Yixing Hospital of Jiangsu University , Wuxi , China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Shan
authors.affiliation: b Department of Radiology , The Affiliated Yixing Hospital of Jiangsu University , Wuxi , China.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Liu
authors.affiliation: b Department of Radiology , The Affiliated Yixing Hospital of Jiangsu University , Wuxi , China.
authors.forename: Tieliang
authors.initials: T
authors.lastname: Ma
authors.affiliation: a Department of Radiology , The Affiliated BenQ Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Xuee
authors.initials: X
authors.lastname: Zhu
authors.affiliation: a Department of Radiology , The Affiliated BenQ Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhou
authors.affiliation: a Department of Radiology , The Affiliated BenQ Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Binghu
authors.initials: B
authors.lastname: Jiang
authors.affiliation: a Department of Radiology , The Affiliated BenQ Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Jichen
authors.initials: J
authors.lastname: Wang
mesh_terms: D000647:Amnesia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*
keywords: amnestic mild cognitive impairment; hippocampus; magnetic resonance imaging; signal intensity; volume