title: Evaluation of geriatric assessment in patients with chronic lymphocytic leukemia: Results of the CLL9 trial of the German CLL study group.
abstract: Multidimensional geriatric assessment (GA) has been demonstrated to predict outcomes in older patients with cancer. This study evaluated GA in a cohort of older patients with chronic lymphocytic leukemia (CLL). Seventy-five of 97 subjects with CLL who were enrolled in a clinical trial of the German CLL Study Group underwent GA prior to the start of study treatment (low-dose chemotherapy with fludarabine). GA included cumulative illness rating scale (CIRS), timed-up-and-go (TUG) test, dementia detection (DEMTECT) test and instrumental activities of daily living (IADL) index. There was little correlation between CIRS, TUG, DEMTECT or IADL results and treatment toxicity, feasibility or efficacy in this study. CIRS and IADL had no statistically significant impact on overall prognosis. However, under-performance in TUG or DEMTECT test was strongly associated with poor survival. The latter findings provide a rationale to further investigate geriatric assessment in CLL and in the context with other CLL treatments.
authors.affiliation: a German CLL Study Group, Department I of Internal Medicine , Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne , Cologne , Germany .|b Department of Geriatric Medicine , St Marien Hospital , Cologne , Germany .
authors.forename: Valentin
authors.initials: V
authors.lastname: Goede
authors.affiliation: a German CLL Study Group, Department I of Internal Medicine , Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne , Cologne , Germany .
authors.forename: Jasmin
authors.initials: J
authors.lastname: Bahlo
authors.affiliation: a German CLL Study Group, Department I of Internal Medicine , Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne , Cologne , Germany .
authors.forename: Viktoria
authors.initials: V
authors.lastname: Chataline
authors.affiliation: a German CLL Study Group, Department I of Internal Medicine , Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne , Cologne , Germany .
authors.forename: Barbara
authors.initials: B
authors.lastname: Eichhorst
authors.affiliation: c Department of Hematology , University Hospital Essen , Essen , Germany .
authors.forename: Jan
authors.initials: J
authors.lastname: Dürig
authors.affiliation: d Department III of Internal Medicine , University Hospital Ulm , Ulm , Germany .
authors.forename: Stephan
authors.initials: S
authors.lastname: Stilgenbauer
authors.affiliation: e Department of Geriatric Medicine , Bonifatius Hospital , Lingen , Germany .
authors.forename: Gerald
authors.initials: G
authors.lastname: Kolb
authors.affiliation: f Department of Oncology , Hematology, Bone Marrow Transplantation with section Pneumology, University Hospital Hamburg-Eppendorf , Hamburg , Germany .|g Tumor and Breast Center ZeTuP , St. Gallen , Switzerland .
authors.forename: Friedemann
authors.initials: F
authors.lastname: Honecker
authors.affiliation: h Department II of Internal Medicine , University Hospital Jena , Jena , Germany , and.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wedding
authors.affiliation: a German CLL Study Group, Department I of Internal Medicine , Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne , Cologne , Germany .|i Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne , Cologne , Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Hallek
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D015897:Comorbidity; D005260:Female; D015577:Geriatric Assessment; D005858:Germany; D006801:Humans; D053208:Kaplan-Meier Estimate; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
keywords: Chronic lymphocytic leukemia; chemotherapy; geriatric assessment