title: Huge epithelioid malignant peripheral nerve sheath tumor in the left axilla: a case report.
abstract: This report describes a patient with a rare huge epithelioid malignant peripheral nerve sheath tumor (MPNST) in the left axilla. A male in his 70s was admitted to our hospital for evaluation of a growing tumor in his left axilla. The tumor was solid and immovable. Examination of a biopsy specimen resulted in a diagnosis of epithelioid MPNST. Two weeks after the biopsy was performed, the tumor grew to 20 cm and became painful, and the patient was unable to feel pressure on his upper arm. Immediately before surgery to remove the tumor, computed tomography suggested the presence of lung metastases. The patient and his family were informed of his disease state, and they elected surgical treatment to ease the symptoms associated with tumor enlargement. Systemic metastases appeared soon after the surgery, and the patient died within 11 weeks. Comparative genomic hybridization (CGH) analysis showed that this tumor was chromosomally unstable, with impairments in gene expression.
authors.affiliation: Department of Gastroenterological Surgery, Clinical Research Center Cancer Research Division, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan ; Department of Gastroenterological Surgery, National Kyushu Medical Center 1-8-1, Jigyohama, Chuo-ward, Fukuoka, 810-8563 Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusumoto
authors.affiliation: Department of Gastroenterological Surgery, Clinical Research Center Cancer Research Division, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Yamaguchi
authors.affiliation: Department of Gastroenterological Surgery, Clinical Research Center Cancer Research Division, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sugiyama
authors.affiliation: Department of Gastroenterological Surgery, Clinical Research Center Cancer Research Division, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Ota
authors.affiliation: Department of Gastroenterological Surgery, Clinical Research Center Cancer Research Division, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Tsutsumi
authors.affiliation: Department of Gastroenterological Surgery, Clinical Research Center Cancer Research Division, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Yasue
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Department of Gastroenterological Surgery, Clinical Research Center Cancer Research Division, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Sakaguchi
authors.affiliation: Department of Gastroenterological Surgery, Clinical Research Center Cancer Research Division, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kusumoto
authors.affiliation: Department of Gastroenterological Surgery, Clinical Research Center Cancer Research Division, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ikejiri
authors.affiliation: Department of Pathology, Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Yoshifuku
authors.initials: Y
authors.lastname: Nakayama
authors.affiliation: Department of Pathology, Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ward, Fukuoka-city, Fukuoka 810-8563 Japan.
authors.forename: Seiya
authors.initials: S
authors.lastname: Momosaki
keywords: Chromosomally unstable; Epithelioid malignant peripheral nerve sheath tumor; Extended resection