title: Effect of obesity and hyperglycemia on benign prostatic hyperplasia in elderly patients with newly diagnosed type 2 diabetes.
abstract: OBJECTIVE
  To investigate the relationship between blood glucose levels, age, body mass index (BMI), and benign prostatic hyperplasia (BPH) in patients with newly diagnosed type 2 diabetes.
  
  
  METHODS
  A total of 141 BPH patients with newly diagnosed type 2 diabetes participated in this study. Their glucose level, international prostate symptom score (IPSS), prostate volume (PV), and maximum urinary flow rate (Qmax) were determined and analyzed.
  
  
  RESULTS
  Compared to patients in 60-69 years of age, those in 70-79 years of age had higher IPSS and PV values (11.10±2.68 vs. 16.09±2.64, respectively; P<0.01; 38.67±4.65 vs. 44.76±2.84, respectively; P<0.01) as did patients ≥80 y (11.10±2.68 vs. 19.87±3.35, respectively; P<0.01; 38.67±4.65 vs. 51.38±3.74, respectively; P<0.01). The Qmax was lower in the ≥80 y group compared to the 60-69 y group (7.91±2.13 vs. 13.50±1.75, respectively; P<0.01). IPSS, PV, and insulin resistance index (HOMA-IR) were higher in patients with a BMI ≥28 kg/m(2) group as compared to those with a BMI <24 kg/m(2) group. IPSS and PV values were higher in patients with HbA1c levels ≥6.5% than in those with HbA1c<6.5% (16.30±3.31 vs. 9.87±1.07, respectively; P<0.01; 45.69±3.97 vs. 36.64±3.30, respectively; P<0.01), and the Qmax was lower (10.61±1.98 vs. 14.40±0.82, respectively; P<0.01).
  
  
  CONCLUSIONS
  Aging, obesity, high glucose level, and insulin resistance increase the risk of BPH progression in elderly patients with newly diagnosed type 2 diabetes. Managing body weight and lowering the level of glycosylated hemoglobin may slow the progression of BPH in people with type 2 diabetes.
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University Beijing, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Miao
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University Beijing, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University Beijing, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University Beijing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xu
keywords: Type 2 diabetes mellitus; benign prostatic hyperplasia; blood glucose level; obesity