title: [Subconjunctival chemotherapy in patients with acquired immunodeficiency syndrome. Experimental study of 3 clinical cases].
abstract: BACKGROUND
  Squamous carcinoma of conjuctive (SCC) is a rare tumour with different geographic frequency. The etiology is multifactorial, and included high exposition to UV and also systematic infections (HPV and HIV). Those tumours have low potential of malignity, but occasionally this type of cancer is capable to provoke local recidive and distant metastasis and finally the death of patients. The aim of this work was to investigate the antitumoral response, the tolerable and safe doses of cysplatin preparation in three patients with HIV with recurrent SCC by subconjuctival and topical administration after conservative surgery.
  
  
  METHODS
  The patients were treated with cysplatin preparation. The treatment was about 3 months in 6 cycles. The patients were clinical follow since the last administration until update.
  
  
  RESULTS
  The evolution was favorable. The patients preserved the eyes and their vision without SCC recidive. One patient died about 2 years after he finalized the treatment with conservative vision and without tumoral activity and the cause was HIV infection.
  
  
  CONCLUSIONS
  Treatment with adjuvant chemotherapy to surgery subconjunctival is effective and tolerable in the population of patients treated.
authors.affiliation: Instituto Nacional de Oncología y Radiobiología. Servicio de Oftalmología, Departamento de Farmacología Clínica, Vicedirección de Asistencia Médica e Investigaciones, La Habana, Cuba. melgares@infomed.sld.cu.
authors.forename: María de los Ángeles
authors.initials: Mde L
authors.lastname: Melgares-Ramos
authors.forename: Deyanira
authors.initials: D
authors.lastname: Carnesoltas-Lázaro
authors.forename: Yiliam Suyen
authors.initials: YS
authors.lastname: Silveira-Melgares
authors.forename: Aníbal
authors.initials: A
authors.lastname: Domínguez-Odio
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D060433:Administration, Ophthalmic; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D003230:Conjunctival Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: Carcinoma; Cisplatin; Conjunctival neoplasms; HIV