title: Multicenter Patch Testing With a Resol Resin Based on Phenol and Formaldehyde Within the International Contact Dermatitis Research Group.
abstract: BACKGROUND
  Contact allergy to phenol-formaldehyde resins (PFRs) based on phenol and formaldehyde is not detected by a p-tertiary-butylphenol-formaldehyde resin included in most baseline patch test series.
  
  
  OBJECTIVE
  The aims of this study were to investigate the contact allergy rate to PFR-2 in an international population and to investigate associated simultaneous allergic reactions.
  
  
  METHODS
  Thirteen centers representing the International Contact Dermatitis Research Group included PFR-2 into their patch test baseline series during a period of 6 months in 2012.
  
  
  RESULTS
  Of 2259 patients tested, 28 (1.2%) reacted to PFR-2. Of those 28 individuals, one had a positive reaction to formaldehyde and 2 to p-tertiary-butylphenol-formaldehyde resin. Simultaneous allergic reactions were noted to colophonium in 3, to Myroxylon pereirae in 5, and to fragrance mix I in 8.
  
  
  CONCLUSIONS
  The contact allergy frequency in the tested population (1.2%) merits its inclusion into the international baseline series and possibly also into other baseline series after appropriate investigations. Significantly, overrepresented simultaneous allergic reactions were noted for M. pereirae and fragrance mix I.
authors.affiliation: From the *Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden; †Allergy Center and Department of Dermatology, University Hospital, Republic University of Uruguay, Montevideo; ‡Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark; §Department of Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg; ∥Department of Dermatology, University Hospital Jena, Germany; ¶Contact Allergy Unit, Department of Dermatology, University Hospital KU Leuven, Belgium; #Department of Dermatology, National Skin Center, Singapore; **MGM Medical College, Kamothe, Mumbai, India; ††Department of Dermatology, UCSF School of Medicine, San Francisco, CA; ‡‡Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; §§Cutaneous Allergy Unit, St John's Institute of Dermatology, St Thomas Hospital, London, United Kingdom; ∥∥Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation, Melbourne, Victoria, Australia; and ¶¶Division of Dermatology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada.
authors.forename: Marléne
authors.initials: M
authors.lastname: Isaksson
authors.forename: Iris
authors.initials: I
authors.lastname: Ale
authors.forename: Klaus
authors.initials: K
authors.lastname: Andersen
authors.forename: Thomas
authors.initials: T
authors.lastname: Diepgen
authors.forename: Peter
authors.initials: P
authors.lastname: Elsner
authors.forename: An
authors.initials: A
authors.lastname: Goossens
authors.forename: Chee-Leok
authors.initials: CL
authors.lastname: Goh
authors.forename: Hemangi
authors.initials: H
authors.lastname: Jerajani
authors.forename: Howard
authors.initials: H
authors.lastname: Maibach
authors.forename: Kayoko
authors.initials: K
authors.lastname: Matsunaga
authors.forename: John
authors.initials: J
authors.lastname: McFadden
authors.forename: Rosemary
authors.initials: R
authors.lastname: Nixon
authors.forename: Denis
authors.initials: D
authors.lastname: Sasseville
authors.forename: Magnus
authors.initials: M
authors.lastname: Bruze
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005557:Formaldehyde / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D029904:Myroxylon / Q000009:adverse effects; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects; D019800:Phenol; D010636:Phenols / Q000009:adverse effects*; D011108:Polymers / Q000009:adverse effects*; D012116:Resins, Plant / Q000009:adverse effects; D012117:Resins, Synthetic / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D010476:Perfume; D010636:Phenols; D011108:Polymers; D012116:Resins, Plant; D012117:Resins, Synthetic; D005557:Formaldehyde; C014273:p-tert-butylphenolformaldehyde resin; D019800:Phenol; C013893:rosin; C011529:phenol-formaldehyde resin