title: Epidemiology, prognostic factors, and management of malignant odontogenic tumors: an analysis of 295 cases.
abstract: OBJECTIVE
  To determine the demographic characteristics, prognostic factors, and management for patients diagnosed with a malignant odontogenic tumor (MOT).
  
  
  METHODS
  The Surveillance, Epidemiology, and End Results (SEER) registry was reviewed for patients diagnosed with MOT from 1973 to 2011. Kaplan-Meier and multivariate Cox regression analyses were performed on patient demographic characteristics and pathologic variables.
  
  
  RESULTS
  The SEER database identified 295 MOT patients. The mean age at diagnosis was 50.5 years (range 5-89 years). Of these patients, 61.7% were male and 38.3% were female. The racial composition was 66.4% White, 22% Black, 6.1% Asian, 3.1% Pacific Islander, 0.3% Native American, and 2.1% Other/Unknown. Kaplan-Meier analysis found an overall survival (OS) and disease-specific survival (DSS) at 5 years of 54% and 67%, respectively. Multivariate analysis of the entire cohort found that age and stage were predictors of OS and that age was a predictor for DSS. For stage I/II MOTs, age and surgical therapy were predictors of OS and DSS, respectively.
  
  
  CONCLUSIONS
  Here we report the largest study to date investigating demographic characteristics, prognostic factors, and management of MOT patients. Determinants of survival for OS and DSS include age, stage, and surgical therapy.
authors.affiliation: Dental Student, UCLA School of Dentistry, Los Angeles, California, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lee
authors.affiliation: Dental Student, UCLA School of Dentistry, Los Angeles, California, USA.
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Tong
authors.affiliation: Master's Student, Department of Statistics, UCLA, Los Angeles, California, USA.
authors.forename: Riki
authors.initials: R
authors.lastname: Patel
authors.affiliation: Research Assistant, UCLA School of Dentistry, Los Angeles, California, USA.
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Go
authors.affiliation: Associate Professor, Section of Oral & Maxillofacial Pathology, UCLA School of Dentistry, Los Angeles, California, USA. Electronic address: Rchristensen@dentistry.ucla.edu.
authors.forename: Russell E
authors.initials: RE
authors.lastname: Christensen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009808:Odontogenic Tumors / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D018426:SEER Program; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology