title: Dietary flavonoids, lignans and colorectal cancer prognosis.
abstract: Flavonoids and lignans are polyphenol classes with anticarcinogenic activities against colorectal cancer (CRC). However, very limited epidemiological evidence exists on their effects on CRC prognosis. This study aimed to evaluate the association between flavonoid and lignan intakes with the risk of CRC recurrence and overall survival in CRC patients. The study followed incident histologically confirmed CRC cases in Barcelona (Spain). Validated dietary questionnaires and lifestyle information were collected at recruitment. An ad hoc food composition database on flavonoids and lignans was compiled by using data from the US Department of Agriculture and Phenol-Explorer databases. Adjusted hazards ratios (HR) and 95% confidence intervals (CIs) were estimated using multivariable Cox models. After 8.6 years of mean follow-up, 133 of 409 (32.5%) participants died and 77 of 319 (24.1%) had a CRC recurrence. Total flavonoids were associated neither with CRC recurrence (HR comparing extreme tertiles 1.13, 95% CI 0.64-2.02; P-trend 0.67) nor with overall survival (HR(T3vsT1) 1.06, 95% CI 0.69-1.65; P-trend 0.78) in the multivariable models. No associations were also observed with either total lignans or any flavonoid subclass intake. In conclusion, the results of the current study do not support a role of flavonoid and lignan intake in the CRC prognosis.
authors.affiliation: Biomarkers Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), Lyon, France.
authors.forename: Raul
authors.initials: R
authors.lastname: Zamora-Ros
authors.affiliation: Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO).|Biomedical Research Institute of Bellvitge (IDIBELL).|CIBER en Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Guinó
authors.affiliation: Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO).|Biomedical Research Institute of Bellvitge (IDIBELL).|CIBER en Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain.
authors.forename: M Henar
authors.initials: MH
authors.lastname: Alonso
authors.affiliation: Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO).|Biomedical Research Institute of Bellvitge (IDIBELL).|CIBER en Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Vidal
authors.affiliation: Biomedical Research Institute of Bellvitge (IDIBELL).|Gastroenterology Service, Hospital de Viladecans, Barcelona, Spain.|Department of Clinical Sciences, Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain.
authors.forename: Mercè
authors.initials: M
authors.lastname: Barenys
authors.affiliation: Biomedical Research Institute of Bellvitge (IDIBELL).|CIBER en Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain.|Gastroenterology Service, University Hospital Bellvitge (HUB).
authors.forename: Antonio
authors.initials: A
authors.lastname: Soriano
authors.affiliation: Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO).|Biomedical Research Institute of Bellvitge (IDIBELL).|CIBER en Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain.|Department of Clinical Sciences, Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain.
authors.forename: Victor
authors.initials: V
authors.lastname: Moreno
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D004032:Diet; D005260:Female; D005419:Flavonoids; D005500:Follow-Up Studies; D006801:Humans; D017705:Lignans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D005419:Flavonoids; D017705:Lignans