title: Diode laser treatment and clinical management of multiple oral lesions in patients with hereditary haemorrhagic telangiectasia.
abstract: Hereditary haemorrhagic telangiectasia (HHT) is rare, and characterised by vascular dysplasia that leads to various symptoms including visceral arteriovenous malformations and mucocutaneous telangiectatic lesions. Our aim was to describe the clinical features and options for the treatment of multiple oral lesions, and to illustrate the efficacy of the diode laser in the treatment of early (<2mm) and advanced lesions (2mm or more). We report 24 patients with 1200 oral telangiectatic lesions, which were often associated with regular bleeding (from monthly to daily), superinfection, pain, and swelling, and treated with multiple sessions of laser according to the number and size of the lesions. Early lesions were treated with a single laser impulse in ultrapulsed mode, and advanced lesions with repeated laser impulses in pulsed mode (t-on 200ms/t-off 500ms), at a power of 8W. Early lesions healed completely after laser photocoagulation with no operative or postoperative complications, while advanced lesions improved with a remarkable reduction in size but more discomfort. Protective occlusal plates were sometimes used to reduce the incidence of new lesions caused by dental trauma. The treatment of oral telangiectatic lesions is still being debated, and it is important to improve quality of life for patients. Diode laser surgery could be an effective treatment for oral lesions in those with hereditary haemorrhagic telangiectasia.
authors.affiliation: Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology, "Aldo Moro" University, P.zza G. Cesare, 11, 70124 Bari, Italy. Electronic address: gianfranco.favia@uniba.it.
authors.forename: G
authors.initials: G
authors.lastname: Favia
authors.affiliation: Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology, "Aldo Moro" University, P.zza G. Cesare, 11, 70124 Bari, Italy. Electronic address: angelatempesta1989@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Tempesta
authors.affiliation: Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology, "Aldo Moro" University, P.zza G. Cesare, 11, 70124 Bari, Italy. Electronic address: lull489@hotmail.it.
authors.forename: L
authors.initials: L
authors.lastname: Limongelli
authors.affiliation: Department of Interdisciplinary Medicine, Geriatric Unit and Rare Disease Center, "Aldo Moro" University, P.zza G. Cesare, 11, 70124 Bari, Italy. Electronic address: patrizia.suppressa@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Suppressa
authors.affiliation: Department of Interdisciplinary Medicine, Geriatric Unit and Rare Disease Center, "Aldo Moro" University, P.zza G. Cesare, 11, 70124 Bari, Italy. Electronic address: carlo.sabba@uniba.it.
authors.forename: C
authors.initials: C
authors.lastname: Sabbà
authors.affiliation: Department of Emergency and Organ Transplantation, Operating Unit of Pathological Anatomy, "Aldo Moro" University, P.zza G. Cesare, 11, 70124 Bari, Italy. Electronic address: eugenio.maiorano@uniba.it.
authors.forename: E
authors.initials: E
authors.lastname: Maiorano
mesh_terms: D001165:Arteriovenous Malformations; D006801:Humans; D053685:Laser Therapy; D054023:Lasers, Semiconductor; D011788:Quality of Life; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000628:therapy*
keywords: Diode laser photocoagulation; Laser treatment; Osler–Weber–Rendu disease; Rare disease; Telangiectasia