title: [Endogenous venous thrombolysis].
abstract: Widely incorporated into vascular surgery pharmacological thrombolysis in treatment for deep vain thrombosis is fraught with a series of unsolved problems requiring further consideration. In spite of aggressive nature of treatment in a series of cases pharmacological thrombolysis sometimes turns out ineffective. Along with it, the results of experimental studies suggest a possibility of accelerating resorption of thrombotic masses and inhibiting remodelling of the venous wall by means of influencing effector cells of endogenous thrombolysis. A detailed study of the mechanisms of thrombolysis would make it possible to formulate strict criteria for carrying out pharmacological thrombolysis and to increase its efficacy.
authors.affiliation: Centre for Diagnosis and Treatment of Venous Diseases, Clinic of Scientific Research Institute of Experimental Medicine, North-West Branch of the RAMS, St. Petersburg, Russia.
authors.forename: O Ya
authors.initials: OY
authors.lastname: Porembskaya
authors.affiliation: Municipal Clinical Hospital #40, Ekaterinburg, Russia.
authors.forename: S M
authors.initials: SM
authors.lastname: Khmelniker
authors.affiliation: Centre for Diagnosis and Treatment of Venous Diseases, Clinic of Scientific Research Institute of Experimental Medicine, North-West Branch of the RAMS, St. Petersburg, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Shaidakov
mesh_terms: D000991:Antithrombins / Q000378:metabolism / Q000494:pharmacology; D002406:Catheterization, Peripheral / Q000379:methods*; D003131:Combined Modality Therapy; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D017063:Outcome Assessment, Health Care; D015912:Thrombolytic Therapy / Q000379:methods*; D020246:Venous Thrombosis / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery
chemical_list: D000991:Antithrombins; D005337:Fibrin