title: Elevated Cardiac Troponin I in Preservation Solution Is Associated With Primary Graft Dysfunction.
abstract: BACKGROUND
  Although primary graft dysfunction (PGD) is a leading cause of mortality and morbidity early post-heart transplant, relatively little is known regarding mechanisms involved in PGD development.
  
  
  RESULTS
  We examined the relationship between cardiac troponin I (cTnI) concentrations in the preservation solution from 43 heart transplant procedures and the development of PGD. Donor hearts were flushed with cold preservation solution (University of Wisconsin [UW] or Custodiol) and stored in the same solution. cTnI concentrations were measured utilizing the i-STAT System and normalized to left ventricular mass. Recipient medical records were reviewed to determine PGD according to the 2014 ISHLT consensus conference. Nineteen patients developed PGD following cardiac transplantation. For both UW and Custodiol, normalized cTnI levels were significantly increased (P = .031 and .034, respectively) for those cases that developed PGD versus no PGD. cTnI levels correlated with duration of ischemic time in the UW group, but not for the Custodiol group. Donor age and donor cTnI (obtained prior to organ procurement) did not correlate with preservation cTnI levels in either UW or Custodiol.
  
  
  CONCLUSIONS
  Increased preservation solution cTnI is associated with the development of PGD suggesting preservation injury may be a dominant mechanism for the development of PGD.
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Schechter
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Watson
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Feger
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Southerland
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Rajashree
authors.initials: R
authors.lastname: Mishra
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina.
authors.forename: Louis R
authors.initials: LR
authors.lastname: Dibernardo
authors.affiliation: Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina; Center of Aging and Human Development, Duke University Medical Center, Durham, North Carolina.
authors.forename: Maragatha
authors.initials: M
authors.lastname: Kuchibhatla
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Jacob N
authors.initials: JN
authors.lastname: Schroder
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Mani A
authors.initials: MA
authors.lastname: Daneshmand
authors.affiliation: Division of Cardiology, Duke University Medical Center, Durham, North Carolina.
authors.forename: Chetan B
authors.initials: CB
authors.lastname: Patel
authors.affiliation: Division of Cardiology, Duke University Medical Center, Durham, North Carolina.
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Rogers
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Carmelo A
authors.initials: CA
authors.lastname: Milano
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina. Electronic address: dawn.bowles@duke.edu.
authors.forename: Dawn E
authors.initials: DE
authors.lastname: Bowles
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006321:Heart; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D019188:Organ Preservation Solutions / Q000009:adverse effects* / Q000737:chemistry; D055031:Primary Graft Dysfunction / Q000453:epidemiology*; D014019:Tissue Donors; D019210:Troponin I / Q000009:adverse effects* / Q000032:analysis
chemical_list: D015415:Biomarkers; D019188:Organ Preservation Solutions; D019210:Troponin I
keywords: Cardiac transplant; biomarkers