title: Hypocholesterolemic Efficacy of Quercetin Rich Onion Juice in Healthy Mild Hypercholesterolemic Adults: A Pilot Study.
abstract: Onion (Allium cepa L.) is widely employed as a food ingredient as well as traditional remedy to treat fever, burns, and scurvy. The present study focused on the modulator efficacy of the quercetin rich onion juice on lipid profile and antioxidant status in mildly hypercholesterolemic subjects. Twenty-four healthy subjects with mild hypercholesterolemia (≧ 200 mg/dL) were recruited and divided into two groups, and they consumed 100 mL of onion juice or placebo every day for 8 weeks. Fasting blood samples were collected at initial, 2nd, 6th, 8th, 10th week for estimating various biochemical assays, as well as anthropometric indices. After 8 weeks of intervention, onion juice greatly decreased (p < 0.05) waist circumference, total cholesterol and LDL-c. In addition, it elevates (p < 0.05) total antioxidation capacity and prolong lag-time of LDL oxidation were also noted. To conclude, drinking onion juice could markedly suppress cholesterol level and elevate total antioxidation capacity. Hence, onion juice was probably recommended for combating various cardiovascular diseases.
authors.affiliation: Department of Neurology, Chung Shan Medical University Hospital, Taichung City, Taiwan, Republic of China.
authors.forename: Tsong-Ming
authors.initials: TM
authors.lastname: Lu
authors.affiliation: Department of Chinese Medicine, Taichung Hospital Ministry of Health and Well-being, Taichung City, Taiwan, Republic of China.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Chiu
authors.affiliation: School of Health Diet and Industry Management, Chung Shan Medical University, 110, Sec. 1, Jianguo North Road, Taichung City, Taiwan, Republic of China.
authors.forename: You-Cheng
authors.initials: YC
authors.lastname: Shen
authors.affiliation: School of Nutrition, Chung Shan Medical University, No. 110, Sec.1, Jianguo N. Rd, Taichung City, 40201, Taiwan, Republic of China.
authors.forename: Chia-Chun
authors.initials: CC
authors.lastname: Chung
authors.affiliation: School of Nutrition, Chung Shan Medical University, No. 110, Sec.1, Jianguo N. Rd, Taichung City, 40201, Taiwan, Republic of China.
authors.forename: Kamesh
authors.initials: K
authors.lastname: Venkatakrishnan
authors.affiliation: School of Nutrition, Chung Shan Medical University, No. 110, Sec.1, Jianguo N. Rd, Taichung City, 40201, Taiwan, Republic of China. wckjff@gmail.com.
authors.forename: Chin-Kun
authors.initials: CK
authors.lastname: Wang
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents; D000975:Antioxidants / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019697:Onions / Q000737:chemistry*; D010084:Oxidation-Reduction; D008517:Phytotherapy; D010865:Pilot Projects; D010919:Placebos; D010936:Plant Extracts / Q000737:chemistry; D011794:Quercetin / Q000008:administration & dosage*; D013624:Taiwan; D055105:Waist Circumference / Q000187:drug effects
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D008078:Cholesterol, LDL; D008055:Lipids; D010919:Placebos; D010936:Plant Extracts; D002784:Cholesterol; D011794:Quercetin
keywords: Antioxidation; Cardiovascular disease; Hypercholesterolemia; Lipoproteins; Total cholesterol