title: The Content of the 14 Metals in Cancellous and Cortical Bone of the Hip Joint Affected by Osteoarthritis.
abstract: The aim of the study was to determine the content of particular elements Ca, Mg, P, Na, K, Zn, Cu, Fe, Mo, Cr, Ni, Ba, Sr, and Pb in the proximal femur bone tissue (cancellous and cortical bone) of 96 patients undergoing total hip replacement for osteoarthritis using ICP-AES and FAAS analytical techniques. The interdependencies among these elements and their correlations depended on factors including age, gender, place of residence, tobacco consumption, alcohol consumption, exposure to environmental pollution, physical activity, and type of degenerative change which were examined by statistical and chemometric methods. The factors that exerted the greatest influence on the elements in the femoral head and neck were tobacco smoking (higher Cr and Ni content in smokers), alcohol consumption (higher concentrations of Ni, Cu in people who consume alcohol), and gender (higher Cu, Zn, and Ni concentrations in men). The factors influencing Pb accumulation in bone tissue were tobacco, alcohol, gender, and age. In primary and secondary osteoarthritis of the hip, the content and interactions of elements are different (mainly those of Fe and Pb). There were no significant differences in the concentrations of elements in the femoral head and neck that could be attributed to residence or physical activity.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Adam Mickiewicz University in Poznań, 61-614 Poznań, Poland.
authors.forename: Anetta
authors.initials: A
authors.lastname: Zioła-Frankowska
authors.affiliation: Department of Orthopedic and Traumatology, W. Dega University Hospital, Poznan University of Medical Sciences, 61-545 Poznań, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Kubaszewski
authors.affiliation: Department of Orthopedic and Traumatology, W. Dega University Hospital, Poznan University of Medical Sciences, 61-545 Poznań, Poland.
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Dąbrowski
authors.affiliation: Department of Water and Soil Analysis, Faculty of Chemistry, Adam Mickiewicz University in Poznań, 61-614 Poznań, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Kowalski
authors.affiliation: Department of Spondyloorthopaedics and Biomechanics of the Spine, W. Dega University Hospital, Poznan University of Medical Sciences, 61-545 Poznań, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Rogala
authors.affiliation: Department of Orthopedic and Traumatology, W. Dega University Hospital, Poznan University of Medical Sciences, 61-545 Poznań, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Strzyżewski
authors.affiliation: Department of Orthopedic and Traumatology, W. Dega University Hospital, Poznan University of Medical Sciences, 61-545 Poznań, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Łabędź
authors.affiliation: Laboratory of Biomaterials and Peri-Implant Bioprocesses Engineering, Department of Process Engineering, Institute of Technology and Chemical Engineering, Poznan University of Technology, 60-965 Poznań, Poland ; Department of Medical Bioengineering Fundamentals, Institute of Technology, Casimir the Great University, 85-064 Bydgoszcz, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Uklejewski
authors.affiliation: Department of Chemistry, Faculty of Science, Masaryk University, 611 37 Brno, Czech Republic.
authors.forename: Karel
authors.initials: K
authors.lastname: Novotny
authors.affiliation: Department of Chemistry, Faculty of Science, Masaryk University, 611 37 Brno, Czech Republic.
authors.forename: Viktor
authors.initials: V
authors.lastname: Kanicky
authors.affiliation: Department of Water and Soil Analysis, Faculty of Chemistry, Adam Mickiewicz University in Poznań, 61-614 Poznań, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Frankowski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000379:methods; D005260:Female; D005270:Femur Head / Q000378:metabolism*; D005272:Femur Neck / Q000378:metabolism; D006621:Hip Joint / Q000378:metabolism*; D006801:Humans; D008297:Male; D008670:Metals / Q000032:analysis*; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism*
chemical_list: D008670:Metals