title: 9-Valent HPV vaccine for cancers, pre-cancers and genital warts related to HPV.
abstract: Human papillomavirus (HPV) is the causative agent of nearly all cervical cancer cases as well as a substantial proportion of anal, vulvar, vaginal, penile and oropharyngeal cancers, making it responsible for approximately 5% of the global cancer burden. The first-generation HPV vaccines that is, quadrivalent HPV type 6/11/16/18 vaccine and bivalent HPV type 16/18 vaccine were licensed in 2006 and 2007, respectively. A second-generation 9-valent HPV type 6/11/16/18/31/33/45/52/58 vaccine with broader cancer coverage was initiated even before the first vaccines were approved. By preventing HPV infection and disease due to HPV31/33/45/52/58, the 9vHPV vaccine has the potential to increase prevention of cervical cancer from 70 to 90%. In addition, the 9vHPV vaccine has the potential to prevent 85-95% of HPV-related vulvar, vaginal and anal cancers. Overall, the 9vHPV vaccine addresses a significant unmet medical need, although further health economics and implementation research is needed.
authors.affiliation: a 1 Faculty of Tropical Medicine, Mahidol University, Nakhon Pathom, Thailand.
authors.forename: Punnee
authors.initials: P
authors.lastname: Pitisuttithum
authors.affiliation: b 2 Merck & Co., Kenilworth, NJ, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Velicer
authors.affiliation: b 2 Merck & Co., Kenilworth, NJ, USA.
authors.forename: Alain
authors.initials: A
authors.lastname: Luxembourg
mesh_terms: D002277:Carcinoma / Q000517:prevention & control* / Q000821:virology; D003218:Condylomata Acuminata / Q000517:prevention & control* / Q000821:virology; D005260:Female; D005833:Genital Neoplasms, Female / Q000517:prevention & control / Q000821:virology; D005834:Genital Neoplasms, Male / Q000517:prevention & control / Q000821:virology; D006801:Humans; D008297:Male; D009959:Oropharyngeal Neoplasms / Q000517:prevention & control / Q000821:virology; D027383:Papillomaviridae / Q000276:immunology; D030361:Papillomavirus Infections / Q000150:complications / Q000517:prevention & control* / Q000821:virology; D053918:Papillomavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D011230:Precancerous Conditions / Q000517:prevention & control* / Q000821:virology
chemical_list: D053918:Papillomavirus Vaccines
keywords: cancer prevention; genital warts; human papillomavirus; pre cancers; prophylactic vaccine