title: Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism.
abstract: Per-Arnt-Sim Kinase (PASK) is an evolutionarily-conserved nutrient-responsive protein kinase that regulates lipid and glucose metabolism, mitochondrial respiration, phosphorylation, and gene expression. Recent data suggests that mammalian PAS kinase is involved in glucose metabolism and acts on pancreatic islet α/β cells and glycogen synthase (GS), affecting insulin secretion and blood glucose levels. In addition, PASK knockout mice (PASK-/-) are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet, implying that PASK may be a new target for metabolic syndrome (MetS) treatment as well as the cellular nutrients and energy sensors-adenosine monophosphate (AMP)-activated protein kinase (AMPK) and the targets of rapamycin (m-TOR). In this review, we will briefly summarize the regulation of PASK on mammalian glucose and lipid metabolism and its possible mechanism, and further explore the potential targets for MetS therapy.
authors.affiliation: Department of Clinical Pharmacy, Shanghai General Hospital, School of medicine, Shanghai Jiaotong University, No.100 Haining Road, Shanghai 200025, China. RainbowDan0513@hotmail.com.
authors.forename: Dan-dan
authors.initials: DD
authors.lastname: Zhang
authors.affiliation: Department of Clinical Pharmacy, Shanghai General Hospital, School of medicine, Shanghai Jiaotong University, No.100 Haining Road, Shanghai 200025, China. grissomzhang@hotmail.com.
authors.forename: Ji-gang
authors.initials: JG
authors.lastname: Zhang
authors.affiliation: Department of Clinical Pharmacy, Shanghai General Hospital, School of medicine, Shanghai Jiaotong University, No.100 Haining Road, Shanghai 200025, China. yzwyy0506@126.com.
authors.forename: Yu-zhu
authors.initials: YZ
authors.lastname: Wang
authors.affiliation: Department of Clinical Pharmacy, Shanghai General Hospital, School of medicine, Shanghai Jiaotong University, No.100 Haining Road, Shanghai 200025, China. liuying2e@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Clinical Pharmacy, Shanghai General Hospital, School of medicine, Shanghai Jiaotong University, No.100 Haining Road, Shanghai 200025, China. gaolinliu@aliyun.com.
authors.forename: Gao-lin
authors.initials: GL
authors.lastname: Liu
authors.affiliation: Department of Clinical Pharmacy, Shanghai General Hospital, School of medicine, Shanghai Jiaotong University, No.100 Haining Road, Shanghai 200025, China. lixiaoyulxb@163.com.
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Li
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004734:Energy Metabolism; D004789:Enzyme Activation; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology; D010179:Pancreas / Q000201:enzymology; D011487:Protein Conformation; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D001786:Blood Glucose; C116037:PAS domain kinases; D017346:Protein Serine-Threonine Kinases
keywords: Per-Arnt-Sim kinase (PASK); glucose and lipid metabolism; metabolic syndrome (MetS); protein regulation