title: The prevalence of mild cognitive impairment with type 2 diabetes mellitus among elderly people in China: A cross-sectional study.
abstract: BACKGROUND
  In absence of curative treatments for dementia with type 2 diabetes mellitus (T2DM), mild cognitive impairment (MCI) in T2DM, the preclinical transitional states of dementia with T2DM has attracted dramatic attention. Our study was to estimate the prevalence and distribution of MCI in T2DM subjects from China, and identify influencing factors of subjects in MCI with T2DM.
  
  
  METHODS
  In the present study, we performed cluster random sampling of 8213 people aged 65 years and older in Tianjin, a metropolitan city, located in northern China. All participants were interviewed and screened for T2DM. 1109 subjects with T2DM were initially screened with American Diabetes Association criteria for diagnosis of diabetes mellitus and were diagnosed with MCI and dementia according to the criteria of DSM-IIIR. The prevalence of MCI and dementia in subjects with T2DM were compared with that in ordinary subjects. Logistic regression analyses were performed to evaluate risk of MCI with T2DM.
  
  
  RESULTS
  Among all 8213 subjects, overall MCI and dementia with T2DM prevalence were 13.5% and 2.34%, respectively. Compared with ordinary subjects, the prevalence of MCI in the present study was more frequent than the prevalence of MCI for the general population in almost each age group. In the univariate analyses, among all diabetic subjects, compared with cognitive intactly subjects, MCI subjects had significantly higher levels of age, current smoking, mean waist circumference, duration from onset of diabetes, insulin intake, systolic BP, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and immunoreactive insulin (IRI). In multivariate logistic regression analyses, variables including current smoking, duration from onset of diabetes, FPG, HbA1c and IRI were significantly associated with increased risk for MCI with T2DM, the ORs were 1.36,1.33,1.17,1.25 and 1.33, respectively (all P<0.05).
  
  
  CONCLUSIONS
  The present study confirms the high prevalence of MCI with T2DM among the elderly population of China. T2DM is related to a higher risk of MCI in a population with a high prevalence of this disorder and may aggravate the clinical picture as a concomitant factor.
authors.affiliation: Department of Cardiology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 30070, China.
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Rujuan
authors.initials: R
authors.lastname: Miao
authors.affiliation: Community Health Service Center, Sanhuailu Street, Binhai New District, Tianjin 300450, China.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Community Health Service Center, Sanhuailu Street, Binhai New District, Tianjin 300450, China.
authors.forename: Mingfei
authors.initials: M
authors.lastname: Cui
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 30070, China. Electronic address: huangguowei@tmu.edu.cn.
authors.forename: Guowei
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China. Electronic address: mf2002245mf@aliyun.com.
authors.forename: Ma
authors.initials: M
authors.lastname: Fei
mesh_terms: D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000208:ethnology; D003430:Cross-Sectional Studies; D003704:Dementia / Q000453:epidemiology* / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000208:ethnology; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D007328:Insulin; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012307:Risk Factors; D014505:Urban Population
chemical_list: D007328:Insulin
keywords: Cross-sectional study; Dementia; Mild cognitive impairment; Prevalence; Type 2 diabetes mellitus