title: Association between polymorphism of MMP-1 promoter and the susceptibility to anterior disc displacement and temporomandibular joint osteoarthritis.
abstract: OBJECTIVE
  To investigate the correlation of the polymorphism of MMP-1 promoter (-1607 1G/2G) with the susceptibility to anterior disc displacement (ADD) and temporomandibular joint osteoarthritis (TMJ OA).
  
  
  METHODS
  A total of 185 healthy individuals (group A), 141 unilateral ADDWR patients (group B), and 321 unilateral ADDWOR patients (group C) were included in the investigation. Group C included 115 patients without TMJ OA (named group C-1) and 206 with TMJ OA (named group C-2). The genotyping of this single nucleotide polymorphism was evaluated by high resolution melting assay. Pairwise comparison between the distributions of genotypes and alleles in these groups was conducted with a multivariate logistic regression model adjusted on the basis of possible covariates.
  
  
  RESULTS
  A significant difference in the 2G2G genotype frequency was found among the different groups on the basis of three sets of comparisons (P(C-A)<0.0005; P(C1-B)=0.049; P(C2-B)=0.018). The susceptibility of 2G2G genotype carriers to ADDWOR with or without TMJ OA was considerably higher than that of other genotypes carriers (OR(C-A)=2.455; OR(C1-B)=1.849; OR(C2-B)=1.912). A significant difference in 1G2G genotype frequency was also observed on the basis of two sets of comparisons (P(C-A)<0.0005; P(C2-B)=0.041). The susceptibility of 1G2G genotype carriers to ADDWOR with or without TMJ OA was also considerably higher than that of other genotype carriers (OR(C-A)=2.641; OR(C2-B)=1.896).
  
  
  CONCLUSIONS
  The -1607 1G/2G polymorphism of MMP-1 promoter may be related to the susceptibility to ADDWOR with or without TMJ OA.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, PR China.
authors.forename: Shufang
authors.initials: S
authors.lastname: Luo
authors.affiliation: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, PR China.
authors.forename: Mohong
authors.initials: M
authors.lastname: Deng
authors.affiliation: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, PR China. Electronic address: longxing_china@hotmail.com.
authors.forename: Xing
authors.initials: X
authors.lastname: Long
authors.affiliation: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, PR China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000235:genetics* / Q000473:pathology; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D008875:Middle Aged; D010003:Osteoarthritis / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D019224:Temporomandibular Joint Disc / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000235:genetics* / Q000473:pathology; D055815:Young Adult
chemical_list: C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1
keywords: Anterior disc displacement; MMP-1; Osteoarthritis; Single nucleotide polymorphism; Temporomandibular disorder