title: Second trimester amniotic fluid myo-inositol concentrations in women later developing gestational diabetes mellitus or pregnancy-induced hypertension.
abstract: OBJECTIVE
  To evaluate myo-inositol concentrations in amniotic fluid in women later developing gestational diabetes and hypertension.
  
  
  METHODS
  A retrospective study was carried out with three groups of amniotic fluid samples (15-18 gestational weeks): 30 gestational hypertension pregnancies, 30 gestational diabetes pregnancies, and 30 normal pregnancy.
  
  
  RESULTS
  A significant difference was observed in myo-inositol concentrations between the median gestational diabetes values (124.0 µmol/L, IQR 90.0-162.5) and the control group values (79.0 µmol/L, IQR 62.0-107.5), but also with gestational hypertension median values (79.0 µmol/L, IQR 67.75-92.0) (p < 0.001).
  
  
  CONCLUSIONS
  This study has shown that myo-inositol concentrations in amniotic fluid increased significantly in women later developing gestational diabetes compared to the control group.
authors.affiliation: a Department of Pediatrics, Gynecology, Microbiology and Biomedical Sciences , University of Messina , Messina , Italy and.
authors.forename: Angelo
authors.initials: A
authors.lastname: Santamaria
authors.affiliation: a Department of Pediatrics, Gynecology, Microbiology and Biomedical Sciences , University of Messina , Messina , Italy and.
authors.forename: Francesco
authors.initials: F
authors.lastname: Corrado
authors.affiliation: a Department of Pediatrics, Gynecology, Microbiology and Biomedical Sciences , University of Messina , Messina , Italy and.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Baviera
authors.affiliation: b A. G. Un. Co. Obstetrics and Gynecology Center , Rome , Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Carlomagno
authors.affiliation: b A. G. Un. Co. Obstetrics and Gynecology Center , Rome , Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Unfer
authors.affiliation: a Department of Pediatrics, Gynecology, Microbiology and Biomedical Sciences , University of Messina , Messina , Italy and.
authors.forename: Rosario
authors.initials: R
authors.lastname: D'anna
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000378:metabolism*; D007294:Inositol / Q000378:metabolism*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies
chemical_list: D007294:Inositol
keywords: Amniotic fluid; fetal metabolism; gestational diabetes; gestational hypertension; myo-inositol