title: Patent cliff mitigation strategies: giving new life to blockbusters.
abstract: With several blockbuster drugs on the brink of another significant patent expiry cliff, innovator pharmaceutical firms are at risk of losing billions of dollars in sales to generic competition. With issues such as staggering R&D costs, reduced productivity and increasing governmental emphasis on pharmacoeconomics, timely planning and implementation of product lifecycle management strategies is becoming indispensable. A variety of strategies designed to mitigate the post-patent expiry revenue loss exist. These approaches range from fairly straightforward measures, such as strategic price cuts and launching own or authorized generics, to complex and lengthy ones, such as new formulations and indications that require companies to reinvent their pharmaceuticals. As patent expiries loom and product pipelines continue to remain thin, proactive planning for generic entry will be critical for pharma companies to drive growth and earnings in a sustainable manner.
authors.affiliation: a Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital , New Delhi 110029, India +91 986 805 1003 ; drashishkakkar@gmail.com.
authors.forename: Ashish Kumar
authors.initials: AK
authors.lastname: Kakkar
mesh_terms: D003132:Commerce / Q000191:economics; D016527:Drug Costs; D004345:Drug Industry / Q000191:economics*; D016568:Drugs, Generic / Q000191:economics*; D004465:Economic Competition / Q000191:economics*; D017850:Economics, Pharmaceutical; D017598:Efficiency, Organizational / Q000191:economics; D006801:Humans; D010330:Patents as Topic; D012106:Research / Q000191:economics
chemical_list: D016568:Drugs, Generic
keywords: Authorized generics; Rx to over-the-counter switching; chiral switching; drug repositioning; lifecycle management; patent cliff