title: Quantitative determination of sodium monofluoroacetate "1080" in infant formulas and dairy products by isotope dilution LC-MS/MS.
abstract: A fast and easy-to-use confirmatory liquid-chromatography tandem mass-spectrometry (LC-MS/MS) based-method was developed for the analysis of the pesticide sodium monofluoroacetate (MFA, also called "1080") in infant formulas and related dairy products. Extraction of the compound encompassed sample reconstitution and liquid-liquid extraction under acidic conditions. Time-consuming solid-phase extraction steps for clean-up and enrichment and tedious derivatisation were thus avoided. Resulting sample extracts were analysed by electrospray ionisation (ESI) in negative mode. Quantification was performed by the isotopic dilution approach using (13)C-labelled MFA as internal standard. The procedure was validated according to the European document SANCO/12571/2013 and performance parameters such as linearity (r(2) > 0.99), precision (RSD(r) ≤ 9%, RSD(iR) ≤ 11%) and recovery (96-117%) fulfilled its requirements. Limit of quantifications (LOQ) was 1 µg kg(-1) for infant formulas and related dairy products except for whey proteins powders with a LOQ of 5 µg kg(-1). Method ruggedness was further assessed in another laboratory devoted to routine testing for quality control.
authors.affiliation: a Analytical Sciences Department, Nestlé Research Centre , Lausanne , Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bessaire
authors.affiliation: a Analytical Sciences Department, Nestlé Research Centre , Lausanne , Switzerland.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Tarres
authors.affiliation: a Analytical Sciences Department, Nestlé Research Centre , Lausanne , Switzerland.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Goyon
authors.affiliation: a Analytical Sciences Department, Nestlé Research Centre , Lausanne , Switzerland.
authors.forename: Pascal
authors.initials: P
authors.lastname: Mottier
authors.affiliation: b Nestle Quality Assurance Centre , Singapore.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Dubois
authors.affiliation: b Nestle Quality Assurance Centre , Singapore.
authors.forename: Wan Ping
authors.initials: WP
authors.lastname: Tan
authors.affiliation: a Analytical Sciences Department, Nestlé Research Centre , Lausanne , Switzerland.
authors.forename: Thierry
authors.initials: T
authors.lastname: Delatour
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003611:Dairy Products / Q000032:analysis*; D005463:Fluoroacetates / Q000032:analysis*; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D007231:Infant, Newborn; D012964:Sodium / Q000032:analysis*; D053719:Tandem Mass Spectrometry
chemical_list: D005463:Fluoroacetates; D012964:Sodium
keywords: 1080; LC-MS/MS; MFA; dairy products; infant formula; milk powder; sodium monofluoroacetate