title: Relationship of the Acoustic Startle Response and Its Modulation to Emotional and Behavioral Problems in Typical Development Children and Those with Autism Spectrum Disorders.
abstract: Auditory hyper-reactivity is a common sensory-perceptual abnormality in autism spectrum disorders (ASD), which interrupts behavioral adaptation. We investigated acoustic startle response (ASR) modulations in 17 children with ASD and 27 with typical development (TD). Compared to TD, children with ASD had larger ASR magnitude to weak stimuli and more prolonged peak startle-latency. We could not find significant difference of prepulse inhibition (PPI) or habituation in ASD children compared to TD. However, habituation and PPI at 70-dB prepulses were negatively related to several subscales of Social Responsiveness Scale and the Strengths and Difficulties Questionnaire, when considering all children. Comprehensive investigation of ASR and its modulation might increase understanding of the neurophysiological impairments underlying ASD and other mental health problems in children.
authors.affiliation: Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo, 187-8553, Japan. htakahashi@ncnp.go.jp.|Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo, 187-8551, Japan. htakahashi@ncnp.go.jp.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo, 187-8553, Japan.
authors.forename: Sahoko
authors.initials: S
authors.lastname: Komatsu
authors.affiliation: Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo, 187-8553, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakahachi
authors.affiliation: Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo, 187-8553, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ogino
authors.affiliation: Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo, 187-8553, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kamio
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000067877:Autism Spectrum Disorder / Q000503:physiopathology* / Q000523:psychology*; D016022:Case-Control Studies; D002648:Child; D004644:Emotions / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D000066553:Problem Behavior / Q000523:psychology; D013216:Reflex, Startle
keywords: Acoustic startle response; Autism spectrum disorders; Habituation; Prepulse inhibition; Sensory-motor gating; Startle latency