title: Prenatal nonylphenol exposure, oxidative and nitrative stress, and birth outcomes: A cohort study in Taiwan.
abstract: Data concerning the effects of prenatal exposures to nonylphenol (NP) and oxidative stress on neonatal birth outcomes from human studies are limited. A total of 146 pregnant women were studied (1) to investigate the association between prenatal NP exposure and maternal oxidative/nitrative stress biomarkers of DNA damage (8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-nitroguanine (8-NO2Gua)) and lipid peroxidation (8-iso-prostaglandin F2α (8-isoPF2α), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)) and (2) to explore the associations among oxidative stress biomarkers, NP exposure, and neonatal birth outcomes, including gestational age, birth weight, length, Ponderal index, and head and chest circumferences. NP significantly increased the 8-OHdG and 8-NO2Gua levels. All infants born to mothers with urinary 8-OHdG levels above the median exhibited a significantly shorter gestational duration (Badjusted = -4.72 days; 95% CI: -8.08 to -1.36 days). No clear association was found between NP levels and birth outcomes. Prenatal 8-OHdG levels might be a novel biomarker for monitoring fetal health related to NP exposure.
authors.affiliation: Department of Pediatrics, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan.
authors.forename: Pei-Wei
authors.initials: PW
authors.lastname: Wang
authors.affiliation: Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei, Taiwan.
authors.forename: Mei-Lien
authors.initials: ML
authors.lastname: Chen
authors.affiliation: Department of Obstetrics & Gynecology, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Huang
authors.affiliation: Division of Pediatrics, Taipei City Hospital, Yangming Branch, Taipei, Taiwan.
authors.forename: Winnie
authors.initials: W
authors.lastname: Yang
authors.affiliation: Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Kuen-Yuh
authors.initials: KY
authors.lastname: Wu
authors.affiliation: Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan. Electronic address: yufang0513@ntu.edu.tw.
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Huang
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000652:urine; D000328:Adult; D015415:Biomarkers / Q000652:urine; D001724:Birth Weight; D015331:Cohort Studies; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D004785:Environmental Pollutants; D005260:Female; D005865:Gestational Age; D006147:Guanine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D007231:Infant, Newborn; D015227:Lipid Peroxidation; D008297:Male; D018811:Maternal Exposure; D018384:Oxidative Stress; D010636:Phenols; D011247:Pregnancy; D011256:Pregnancy Outcome; D013624:Taiwan / Q000453:epidemiology
chemical_list: C095838:8-nitroguanine; D015415:Biomarkers; D004785:Environmental Pollutants; D010636:Phenols; C075750:8-epi-prostaglandin F2alpha; D006147:Guanine; C025256:nonylphenol; D000080242:8-Hydroxy-2'-Deoxyguanosine; D015237:Dinoprost; D003849:Deoxyguanosine; D000111:Acetylcysteine
keywords: Birth outcomes; Gestational age; Lipid peroxidation; Nonylphenol; Oxidative and nitrative DNA damage