title: Healthy Aging 5 Years After a Period of Daily Supplementation With Antioxidant Nutrients: A Post Hoc Analysis of the French Randomized Trial SU.VI.MAX.
abstract: This study's objective was to investigate healthy aging in older French adults 5 years after a period of daily nutritional-dose supplementation with antioxidant nutrients. The study was based on the double-blind, randomized trial, Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) Study (1994-2002) and the SU.VI.MAX 2 Follow-up Study (2007-2009). During 1994-2002, participants received a daily combination of vitamin C (120 mg), β-carotene (6 mg), vitamin E (30 mg), selenium (100 µg), and zinc (20 mg) or placebo. Healthy aging was assessed in 2007-2009 by using multiple criteria, including the absence of major chronic disease and good physical and cognitive functioning. Data from a subsample of the SU.VI.MAX 2 cohort, initially free of major chronic disease, with a mean age of 65.3 years in 2007-2009 (n = 3,966), were used to calculate relative risks. Supplementation was associated with a greater healthy aging probability among men (relative risk = 1.16, 95% confidence interval: 1.04, 1.29) but not among women (relative risk = 0.98, 95% confidence interval: 0.86, 1.11) or all participants (relative risk = 1.07, 95% confidence interval: 0.99, 1.16). Moreover, exploratory subgroup analyses indicated effect modification by initial serum concentrations of zinc and vitamin C. In conclusion, an adequate supply of antioxidant nutrients (equivalent to quantities provided by a balanced diet rich in fruits and vegetables) may have a beneficial role for healthy aging.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Assmann
authors.forename: Valentina A
authors.initials: VA
authors.lastname: Andreeva
authors.forename: Claude
authors.initials: C
authors.lastname: Jeandel
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
authors.forename: Pilar
authors.initials: P
authors.lastname: Galan
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Kesse-Guyot
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage; D002908:Chronic Disease / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D019587:Dietary Supplements / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D005638:Fruit; D006293:Health Promotion / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors; D012494:Sampling Studies; D014131:Trace Elements / Q000008:administration & dosage*; D014675:Vegetables; D014810:Vitamin E / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage*; D017967:Zinc Compounds / Q000008:administration & dosage; D019207:beta Carotene / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D014131:Trace Elements; D014815:Vitamins; D017967:Zinc Compounds; D019207:beta Carotene; D014810:Vitamin E; D001205:Ascorbic Acid
keywords: aging; antioxidants; dietary supplements; minerals; randomized controlled trial; vitamins