title: Secondary metabolites from Aspergillus fumigatus, an endophytic fungus from the liverwort Heteroscyphus tener (Steph.) Schiffn.
abstract: Three new metabolites, asperfumigatin (1), isochaetominine (10), and 8'-O-methylasterric acid (21), together with nineteen known compounds, were obtained from the culture of Aspergillus fumigatus, an endophytic fungus from the Chinese liverwort Heteroscyphus tener (Steph.) Schiffn. Their structures were established by extensive analysis of the spectroscopic data. The absolute configurations of 1 and 10 were determined by analysis of their respective CD spectra. Cytotoxicity of these isolates against four human cancer cell lines was also determined.
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China (phone: +86-531-88382012; fax: +86-531-88382548).
authors.forename: Fei
authors.initials: F
authors.lastname: Xie
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China (phone: +86-531-88382012; fax: +86-531-88382548).
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Li
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China (phone: +86-531-88382012; fax: +86-531-88382548).
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Zhou
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Xu
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China (phone: +86-531-88382012; fax: +86-531-88382548).
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Yuan
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China (phone: +86-531-88382012; fax: +86-531-88382548). louhongxiang@sdu.edu.cn.
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000737:chemistry* / Q000502:physiology*; D045744:Cell Line, Tumor; D035926:Hepatophyta / Q000382:microbiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents
keywords: Asperfumigatin; Aspergillus fumigatus; Asterric acid, 8′-O-methyl-; Cytotoxic activity; Isochaetominine; Metabolites