title: Development of a Novel Biodegradable Metallic Stent Based on Microgalvanic Effect.
abstract: The implementation of biodegradable stents has the potential to revolutionize obstructive coronary artery disease treatment. Limitations still currently exist, however, that prevent biodegradable stents from replacing permanent metallic stents in the global market. The ideal combination of stent properties, including sufficient mechanical strength, controlled degradation, and biocompatibility, has yet to be realized. A novel manufacturing process is proposed that utilizes cold gas-dynamic spraying to fabricate a metal structure with significantly reduced grain size. Iron and stainless steel 316L are combined to form a novel amalgamate with enhanced mechanical strength and a controllable degradation rate, due to the resulting microgalvanic reaction. Flat specimens composed of iron and 316L are fabricated in various compositions, and mechanical and degradation tests were conducted. Femto laser techniques are utilized to produce stents composed of 80% Fe and 20% stainless steel 316L. The in vitro degradation behaviour of the stent is investigated using static and dynamic corrosion tests. It is shown that the corrosion rate can be adjusted to desired values, by varying the weight percentage of iron and stainless steel 316L within the amalgamate.
authors.affiliation: Department of Mechanical Engineering, McGill University, Montreal, QC, Canada.|Montreal Heart Institute, Montreal, QC, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Frattolin
authors.affiliation: Department of Mechanical Engineering, McGill University, Montreal, QC, Canada.
authors.forename: Rajib
authors.initials: R
authors.lastname: Barua
authors.affiliation: Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aydin
authors.affiliation: Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada.
authors.forename: Sriraman
authors.initials: S
authors.lastname: Rajagopalan
authors.affiliation: Department of Mechanical Engineering, McGill University, Montreal, QC, Canada.|Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Milan, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Gottellini
authors.affiliation: Department of Chemical Engineering, McGill University, Montreal, QC, Canada.
authors.forename: Richard
authors.initials: R
authors.lastname: Leask
authors.affiliation: Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Yue
authors.affiliation: Department of Mechanical Engineering, McGill University, Montreal, QC, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Frost
authors.affiliation: Department of Mechanical Engineering, McGill University, Montreal, QC, Canada.|Interventional Cardiology Laboratories, Quebec Heart and Lung Institute, Laval University, Quebec City, QC, Canada.
authors.forename: Olivier F
authors.initials: OF
authors.lastname: Bertrand
authors.affiliation: Department of Mechanical Engineering, McGill University, Montreal, QC, Canada. rosaire.mongrain@mcgill.ca.|Montreal Heart Institute, Montreal, QC, Canada. rosaire.mongrain@mcgill.ca.|McGill University, Macdonald Engineering Building, Room 369, 817 rue Sherbrooke Ouest, Montreal, QC, H3A 0C3, Canada. rosaire.mongrain@mcgill.ca.
authors.forename: Rosaire
authors.initials: R
authors.lastname: Mongrain
mesh_terms: D020341:Absorbable Implants; D007501:Iron / Q000737:chemistry*; D008956:Models, Chemical; D013193:Stainless Steel / Q000737:chemistry*; D015607:Stents
chemical_list: D013193:Stainless Steel; D007501:Iron
keywords: Biodegradable stent; Cold spray; Coronary artery disease; Degradation; Microgalvanic corrosion