title: Polarized protein transport and lumen formation during epithelial tissue morphogenesis.
abstract: One of the major challenges in biology is to explain how complex tissues and organs arise from the collective action of individual polarized cells. The best-studied model of this process is the cross talk between individual epithelial cells during their polarization to form the multicellular epithelial lumen during tissue morphogenesis. Multiple mechanisms of apical lumen formation have been proposed. Some epithelial lumens form from preexisting polarized epithelial structures. However, de novo lumen formation from nonpolarized cells has recently emerged as an important driver of epithelial tissue morphogenesis, especially during the formation of small epithelial tubule networks. In this review, we discuss the latest findings regarding the mechanisms and regulation of de novo lumen formation in vitro and in vivo.
authors.affiliation: Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045; email: rytis.prekeris@ucdenver.edu.
authors.forename: Alex J
authors.initials: AJ
authors.lastname: Blasky
authors.affiliation: Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045; email: rytis.prekeris@ucdenver.edu.
authors.forename: Anthony
authors.initials: A
authors.lastname: Mangan
authors.affiliation: Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045; email: rytis.prekeris@ucdenver.edu.
authors.forename: Rytis
authors.initials: R
authors.lastname: Prekeris
mesh_terms: D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D009024:Morphogenesis / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology*
keywords: coalescence; epithelial; lumenogenesis