title: Intralymphatic Spread Is a Common Finding in Cutaneous CD30+ Lymphoproliferative Disorders.
abstract: An intralymphatic variant of the cutaneous CD30 lymphoproliferative disorders (cutaneous anaplastic large cell lymphoma [ALCL] and lymphomatoid papulosis [LyP]) has been described recently. We retrieved 60 cases of ALCL of the skin (primary cutaneous: 37; cases with concomitant involvement of 1 regional lymph node: 4; skin involvement from systemic disease: 4; cases with staging results unknown: 15) and 16 cases of LyP, to evaluate the presence of lymphatic vessel involvement by neoplastic cells. A D2-40 immunohistochemical staining was used to highlight lymphatic vessels. Lymphatic vessel involvement was found in 36 cases (60%) of ALCL (primary cutaneous: 24; concomitant: 3; secondary cutaneous: 4; staging unknown: 5), and in 6 cases (37.5%) of LyP. Follow-up data, available in 28 patients with ALCL and 11 with LyP, suggested that lymphatic vessel involvement had no negative prognostic implication. Our study demonstrates that cutaneous CD30 lymphoproliferative disorders are frequently characterized by involvement of the lymphatic vessels. The intralymphatic variant of ALCL and LyP may be explained, at least in part, by a particular lymphotropism of the neoplastic cells of cutaneous CD30 lymphoproliferative disorders.
authors.affiliation: *Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria †Anatomic Pathology Unit, Gaetano Rummo Hospital, Benevento ‡Dermatology Unit, University of Sassari, Sassari §Department of Dermatopathology, San Gallicano Dermatology Institute, Rome, Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Ferrara
authors.forename: Luca
authors.initials: L
authors.lastname: Ena
authors.forename: Carlo
authors.initials: C
authors.lastname: Cota
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cerroni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058846:Antibodies, Monoclonal, Murine-Derived; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis*; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000276:immunology* / Q000473:pathology*; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000276:immunology* / Q000473:pathology*; D017731:Lymphomatoid Papulosis / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology*
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen; C500987:monoclonal antibody D2-40