title: Diabetes-related dysfunction of the small intestine and the colon: focus on motility.
abstract: In contrast to gastric dysfunction, diabetes-related functional impairments of the small and large intestine have been studied less intensively. The gastrointestinal tract accomplishes several functions, such as mixing and propulsion of luminal content, absorption and secretion of ions, water, and nutrients, defense against pathogens, and elimination of waste products. Diverse functions of the gut are regulated by complex interactions among its functional elements, including gut microbiota. The network-forming tissues, the enteric nervous system) and the interstitial cells of Cajal, are definitely impaired in diabetic patients, and their loss of function is closely related to the symptoms in diabetes, but changes of other elements could also play a role in the development of diabetes mellitus-related motility disorders. The development of our understanding over the recent years of the diabetes-induced dysfunctions in the small and large intestine are reviewed in this article.
authors.affiliation: 1st Department of Medicine, Semmelweis University, Korányi Sándor utca 2/a, 1083, Budapest, Hungary. horvathjviktor@gmail.com.
authors.forename: Viktor József
authors.initials: VJ
authors.lastname: Horváth
authors.affiliation: 1st Department of Medicine, Semmelweis University, Korányi Sándor utca 2/a, 1083, Budapest, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Putz
authors.affiliation: Fejér Megyei Szent György Egyetemi Oktató Kórház, Székesfehérvár, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Izbéki
authors.affiliation: 1st Department of Medicine, Semmelweis University, Korányi Sándor utca 2/a, 1083, Budapest, Hungary.
authors.forename: Anna Erzsébet
authors.initials: AE
authors.lastname: Körei
authors.affiliation: 1st Department of Medicine, Semmelweis University, Korányi Sándor utca 2/a, 1083, Budapest, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Gerő
authors.affiliation: 1st Department of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Lengyel
authors.affiliation: 1st Department of Medicine, Semmelweis University, Korányi Sándor utca 2/a, 1083, Budapest, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Kempler
authors.affiliation: 1st Department of Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Várkonyi
mesh_terms: D000818:Animals; D003106:Colon / Q000503:physiopathology*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology*; D017615:Enteric Nervous System; D005769:Gastrointestinal Motility; D006801:Humans; D007421:Intestine, Small / Q000503:physiopathology*
keywords: Diabetes mellitus; Dysfunction; Enteric nerves; Gut microbiota; Interstitial cells of Cajal; Small and large bowel