title: Enhanced Diffusion of Enzymes that Catalyze Exothermic Reactions.
abstract: Enzymes have been recently found to exhibit enhanced diffusion due to their catalytic activities. A recent experiment [C. Riedel et al., Nature (London) 517, 227 (2015)] has found evidence that suggests this phenomenon might be controlled by the degree of exothermicity of the catalytic reaction involved. Four mechanisms that can lead to this effect, namely, self-thermophoresis, boost in kinetic energy, stochastic swimming, and collective heating are critically discussed, and it is shown that only the last two can be strong enough to account for the observations. The resulting quantitative description is used to examine the biological significance of the effect.
authors.affiliation: Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford OX1 3NP, United Kingdom.
authors.forename: Ramin
authors.initials: R
authors.lastname: Golestanian
mesh_terms: D001693:Biological Transport, Active; D002384:Catalysis; D004058:Diffusion; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D008956:Models, Chemical; D013269:Stochastic Processes; D013816:Thermodynamics
chemical_list: D004798:Enzymes