title: α-Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice.
abstract: Previous studies have shown that α-mangostin (α-MG) suppresses intracellular fat accumulation and stimulation of lipolysis in in vitro systems. Together with the relatively high distribution of α-MG in liver and fat, these observations made it possible to propose a plausible hypothesis that an α-MG supplement may regulate hepatic steatosis and obesity. An α-MG supplement (50 mg/kg) reduced the body weight gain (13.8%) and epidymal and retroperitoneal fat mass accumulation (15.0 and 11.3%, respectively), as well as the biochemical serum profiles such as cholesterol [TC (26.9%), LDL-C (39.1%), and HDL-C (15.3%)], glucose (30.2%), triglyceride (29.7%), and fatty acid (30.3%) levels in high-fat fed mice compared with the high-fat diet-treated group, indicating that α-MG may regulate lipid metabolism. In addition, an α-MG supplement up-regulated hepatic AMPK, SirT1, and PPARγ levels compared with the high-fat diet states, suggesting that α-MG regulates hepatic steatosis and obesity through the SirT1-AMPK and PPARγ pathways in high-fat diet-induced obese mice.
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, South Korea.
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Choi
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, South Korea.
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Bae
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, South Korea.
authors.forename: Hee-Sung
authors.initials: HS
authors.lastname: Chae
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, South Korea.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Kim
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, South Korea.
authors.forename: Yim
authors.initials: Y
authors.lastname: Sreymom
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, South Korea.
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.affiliation: Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation , 80 Dongnae-ro, Dong-gu, Daegu 701-310, South Korea.
authors.forename: Ha Young
authors.initials: HY
authors.lastname: Jang
authors.affiliation: College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, South Korea.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects; D005234:Fatty Liver / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism*; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism*; D044004:Xanthones / Q000008:administration & dosage*
chemical_list: D047495:PPAR gamma; D044004:Xanthones; D055372:AMP-Activated Protein Kinases; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; C021053:mangostin
keywords: AMPK; SirT1; hepatic steatosis; obesity; α-mangostin