title: G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health.
abstract: Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism.
authors.affiliation: Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea. ; Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University, Asan, Korea.
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Tae-Hee
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Hae-Hyeog
authors.initials: HH
authors.lastname: Lee
keywords: Estradiol; Estrogens; GTP-binding proteins; Genomics