title: Bioaccumulation of decamethylpentacyclosiloxane (D5): A review.
abstract: Decamethylpentacyclosiloxane (D5) is a widely used, high-production volume personal care product with an octanol-water partition coefficient (log K(OW)) of 8.09. Because of D5's high K(OW) and widespread use, it is subject to bioaccumulation assessments in many countries. The present study provides a compilation and an in-depth, independent review of bioaccumulation studies involving D5. The findings indicate that D5 exhibits depuration rates in fish and mammals that exceed those of extremely hydrophobic, nonbiotransformable substances; that D5 is subject to biotransformation in mammals and fish; that observed bioconcentration factors in fish range between 1040 L/kg and 4920 L/kg wet weight in laboratory studies using non-radiolabeled D5 and between 5900 L/kg and 13 700 L/kg wet weight in an experiment using C(14) radiolabeled D5; and that D5 was not observed to biomagnify in most laboratory experiments and field studies. Review of the available studies shows a high degree of internal consistency among findings from different studies and supports a broad comprehensive approach in bioaccumulation assessments that includes information from studies with a variety of designs and incorporates multiple bioaccumulation measures in addition to the K(OW) and bioconcentration factor.
authors.affiliation: School of Resource and Environmental Management, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Frank A P C
authors.initials: FA
authors.lastname: Gobas
authors.affiliation: Dow Corning, Health & Environmental Sciences, Midland, Michigan, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Powell
authors.affiliation: Dow Corning, Health & Environmental Sciences, Midland, Michigan, USA.
authors.forename: Kent B
authors.initials: KB
authors.lastname: Woodburn
authors.affiliation: Wildlife International, Easton, Maryland, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: Springer
authors.affiliation: Department of Biology, Institute of Applied Sciences, University of North Texas, Denton, Texas, USA.
authors.forename: Duane B
authors.initials: DB
authors.lastname: Huggett
mesh_terms: D000465:Algorithms; D000818:Animals; D058448:Biota; D001711:Biotransformation; D002170:Canada; D004785:Environmental Pollutants / Q000032:analysis* / Q000737:chemistry; D004787:Environmental Pollution / Q000331:legislation & jurisprudence*; D005399:Fishes; D019015:Geologic Sediments / Q000032:analysis; D008055:Lipids / Q000737:chemistry; D008322:Mammals; D008954:Models, Biological; D012833:Siloxanes / Q000032:analysis* / Q000737:chemistry
chemical_list: D004785:Environmental Pollutants; D008055:Lipids; D012833:Siloxanes; C114768:decamethylcyclopentasiloxane
keywords: Bioaccumulation; Biomagnification; Trophic magnification