title: 2-Allylaminothiazole and 2-allylaminodihydrothiazole derivatives: synthesis, characterization, and evaluation of bioactivity.
abstract: Some reactions of selected chlorooxoesters and haloesters with a 1-allylthiourea under various conditions have been performed. The reactions have been performed in methanol in alkaline and neutral environment. Condensation of 1-allylthiourea with chlorooxoesters has been further led via acetal as intermediate compound. As a result, the compounds containing thiazole and a 4,5-dihydrothiazole ring with a good yield have been obtained. The structures of the compounds were verified by1H NMR,13C NMR as well as X-ray diffraction analysis. Due to the potential biological activity of the synthesized compounds, the parameters of their bioavailability have been determined, and the probability of pharmacological action has been defined. All of the obtained compounds fulfilled the rule of five, which indicate their good absorption after oral intake. The probability of pharmacological action and potential targets calculated for the obtained compounds show that they can be potential drugs.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Studzińska
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Karczmarska-Wódzka
authors.affiliation: Department of Crystallochemistry and Biocrystallography, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Toruń, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Kozakiewicz
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Kołodziejska
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Paprocka
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Wróblewski
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Augustyńska
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
authors.forename: Bożena
authors.initials: B
authors.lastname: Modzelewska-Banachiewicz
keywords: Heterocycles; Organic synthesis; Structure–activity relationships; Thiazole derivatives; X-ray structure determination