title: MOF nanoparticles coated by lipid bilayers and their uptake by cancer cells.
abstract: We report the synthesis of MOF@lipid nanoparticles as a versatile and powerful novel class of nanocarriers based on metal-organic frameworks (MOFs). We show that the MOF@lipid system can effectively store dye molecules inside the porous scaffold of the MOF while the lipid bilayer prevents their premature release. Efficient uptake of the MOF@lipid nanoparticles by cancer cells makes these nanocarriers promising for drug delivery and diagnostic purposes.
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 11 (E), 81377 München, Germany. stefan.wuttke@cup.uni-muenchen.de bein@cup.lmu.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Wuttke
authors.affiliation: Department of Pharmacy University of Munich (LMU), Butenandtstraße 5, 81377 München, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Braig
authors.affiliation: Faculty of Physics and Center for NanoScience (CeNS), University of Munich (LMU), Geschwister Scholl Platz 1, 80539 München, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Preiß
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 11 (E), 81377 München, Germany. stefan.wuttke@cup.uni-muenchen.de bein@cup.lmu.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimpel
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 11 (E), 81377 München, Germany. stefan.wuttke@cup.uni-muenchen.de bein@cup.lmu.de.
authors.forename: Johannes
authors.initials: J
authors.lastname: Sicklinger
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 11 (E), 81377 München, Germany. stefan.wuttke@cup.uni-muenchen.de bein@cup.lmu.de.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bellomo
authors.affiliation: Faculty of Physics and Center for NanoScience (CeNS), University of Munich (LMU), Geschwister Scholl Platz 1, 80539 München, Germany.
authors.forename: Joachim O
authors.initials: JO
authors.lastname: Rädler
authors.affiliation: Department of Pharmacy University of Munich (LMU), Butenandtstraße 5, 81377 München, Germany.
authors.forename: Angelika M
authors.initials: AM
authors.lastname: Vollmar
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstraße 11 (E), 81377 München, Germany. stefan.wuttke@cup.uni-muenchen.de bein@cup.lmu.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bein
mesh_terms: D045744:Cell Line, Tumor; D002857:Chromium / Q000737:chemistry; D004337:Drug Carriers; D005290:Ferric Compounds / Q000737:chemistry; D019793:Fluorescein / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D005997:Glycerylphosphorylcholine / Q000031:analogs & derivatives / Q000737:chemistry; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010713:Phosphatidylcholines; D016062:Porosity
chemical_list: D004337:Drug Carriers; D005290:Ferric Compounds; D005456:Fluorescent Dyes; D008051:Lipid Bilayers; D009942:Organometallic Compounds; D010713:Phosphatidylcholines; D002857:Chromium; D005997:Glycerylphosphorylcholine; C017251:1,2-oleoylphosphatidylcholine; D019793:Fluorescein