title: Targeting Th17 Effector Cytokines for the Treatment of Autoimmune Diseases.
abstract: Interleukin (IL)-17-producing T cells, especially T helper (Th)17 cells, play a critical role in the pathogenesis of a variety of autoimmune inflammatory diseases. The pathogenic function of Th17 cells results from their production of Th17 effector cytokines, namely IL-17 (or IL-17A), IL-17F, IL-22 and IL-26. The importance of IL-17 has been demonstrated by antibody neutralization studies in both animal models of autoimmune diseases as well as in human clinical trials. This review highlights the current knowledge of the clinical aspects of the Th17 cytokines as well as therapeutic antibodies against IL-17, IL-17F, IL-17 receptor, IL-22, IL-26 and granulocyte macrophage colony-stimulating factor for the future treatment of autoimmune inflammatory diseases.
authors.affiliation: Tempero, GlaxoSmithKline, Cambridge, MA, 02139, USA.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamagata
authors.affiliation: Tempero, GlaxoSmithKline, Cambridge, MA, 02139, USA.
authors.forename: Jill
authors.initials: J
authors.lastname: Skepner
authors.affiliation: Tempero, GlaxoSmithKline, Cambridge, MA, 02139, USA. JianfeiYang2012@gmail.com.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D019138:Antibodies, Blocking / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D004195:Disease Models, Animal; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology*; D000097043:Interleukin-22
chemical_list: D019138:Antibodies, Blocking; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D020381:Interleukin-17; D007378:Interleukins; D000097043:Interleukin-22; C406767:IL26 protein, human
keywords: Autoimmune disease; IL-17; IL-22; IL-26; Th17