title: Plasma Polymerization of 1,2-Diaminocyclohexane for Covalent Bonding of Bone Morphogenic Protein-2 on Titanium Surface.
abstract: Among the bone morphogenic protein (BMP) family members, BMP-2 is a potent osteoinductive factor that plays key roles during bone formation. In this study, plasma polymerization of 1,2-diaminocyclohexane (DACH) was performed to immobilize the BMP-2 on Ti surface. The plasma polymerization of DACH was carried out at a discharge power of 60 W and 100 W under a pressure of 10 mTorr for 90 sec. The BMP-2 was successfully immobilized on the DACH plasma treated Ti surface. The BMP-2 immobilized Ti surface showed the excellent cell differentiation. The results indicate that the DACH plasma polymerized Ti surface has a potential for immobilization of biomolecules in bone tissue engineering.
authors.forename: Geon Soo
authors.initials: GS
authors.lastname: Shin
authors.forename: Byung Hoon
authors.initials: BH
authors.lastname: Kim
authors.forename: Young Hyoun
authors.initials: YH
authors.lastname: Hwang
authors.forename: Yeong Mu
authors.initials: YM
authors.lastname: Ko
mesh_terms: D000327:Adsorption; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000737:chemistry* / Q000494:pharmacology*; D018786:Bone Substitutes / Q000138:chemical synthesis*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D010012:Osteogenesis / Q000187:drug effects; D010316:Particle Size; D058626:Plasma Gases / Q000737:chemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: C525719:Bmp2 protein, mouse; D055396:Bone Morphogenetic Protein 2; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D058626:Plasma Gases; D014025:Titanium