title: Cutaneous metastasis as an initial presentation of a non-functioning pancreatic neuroendocrine tumor.
abstract: Non-functioning pancreatic neuroendocrine tumors (NF-PNETs) are rare tumors that account for 2% of all pancreatic malignancy. About 60% of NF-PNETs present distant metastases and usually hepatic metastases. However, cutaneous metastases are very rare. Herein, we report our experience with a 60-year-old male who visited our outpatient clinic with a mass on his left hip. An abdominal computerized tomography scan demonstrated not only a left hip mass and an enlarged left inguinal lymph node, but also a huge heterogeneous enhancing mass on the pancreas. Initially, we removed the metastatic lesions, which was a small cell neuroendocrine carcinoma with 50% of the Ki-67 index in the histopathological report. After 3 wk, we performed a total pancreatectomy and a total gastrectomy. Four weeks after the 1(st) operation, we detected a recurrence at the operative bed on his left hip, and subsequently removed the recurring mass. The patient was receiving chemotherapy based on etoposide and cisplatin treatment.
authors.affiliation: Woo Young Shin, Keon Young Lee, Seung Ik Ahn, Shin-Young Park, Keun-Myoung Park, Department of Surgery, Inha University Hospital, Inha University College of Medicine, Incheon 400-711, South Korea.
authors.forename: Woo Young
authors.initials: WY
authors.lastname: Shin
authors.affiliation: Woo Young Shin, Keon Young Lee, Seung Ik Ahn, Shin-Young Park, Keun-Myoung Park, Department of Surgery, Inha University Hospital, Inha University College of Medicine, Incheon 400-711, South Korea.
authors.forename: Keon Young
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Woo Young Shin, Keon Young Lee, Seung Ik Ahn, Shin-Young Park, Keun-Myoung Park, Department of Surgery, Inha University Hospital, Inha University College of Medicine, Incheon 400-711, South Korea.
authors.forename: Seung Ik
authors.initials: SI
authors.lastname: Ahn
authors.affiliation: Woo Young Shin, Keon Young Lee, Seung Ik Ahn, Shin-Young Park, Keun-Myoung Park, Department of Surgery, Inha University Hospital, Inha University College of Medicine, Incheon 400-711, South Korea.
authors.forename: Shin-Young
authors.initials: SY
authors.lastname: Park
authors.affiliation: Woo Young Shin, Keon Young Lee, Seung Ik Ahn, Shin-Young Park, Keun-Myoung Park, Department of Surgery, Inha University Hospital, Inha University College of Medicine, Incheon 400-711, South Korea.
authors.forename: Keun-Myoung
authors.initials: KM
authors.lastname: Park
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D059146:Metastasectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018358:Neuroendocrine Tumors / Q000556:secondary* / Q000601:surgery; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012086:Reoperation; D012878:Skin Neoplasms / Q000556:secondary* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005047:Etoposide; D002945:Cisplatin
keywords: Neoplasm metastasis; Neuroendocrine tumor; Pancreas; Pancreatectomy; Skin neoplasm