title: Hypocholesterolemia predicts relapses in patients with Takayasu arteritis.
abstract: OBJECTIVE
  The aim of this study is to identify variables at diagnosis to predict the subsequent relapse in patients with Takayasu arteritis (TA).
  
  
  METHODS
  We retrospectively analyzed 33 patients with TA in our hospitals from April 2000 to July 2015. We collected baseline variables at diagnosis including clinical symptoms and laboratory data using medical records and investigated associations of these indices with subsequent relapses.
  
  
  RESULTS
  The patients included two males and 31 females (94%). The median age at diagnosis was 39 years old, and the median follow-up duration was 90 months. Relapse was noted in 18 patients (55%). Only lower total cholesterol (Tcho) [median, 117 mg/dL (relapse) vs. 182 mg/dL (nonrelapse)] was preferentially distributed in the relapse group as compared with the non-relapse group. Multivariable logistic analysis showed that hypocholesterolemia (<150 mg/dL) at diagnosis was the only predictor of subsequent relapse (odds ratio: 5.43, 95% confidence interval: 1.13-30.19; p = 0.035). The nonrelapse survival rate was significantly lower in the group with a Tcho level <150 mg/dL by Kaplan-Meier estimate (p < 0.001).
  
  
  CONCLUSIONS
  We found that hypocholesterolemia at diagnosis is a predictor of subsequent relapse in patients with TA.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Fukui
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Ichinose
authors.forename: Sosuke
authors.initials: S
authors.lastname: Tsuji
authors.forename: Masataka
authors.initials: M
authors.lastname: Umeda
authors.forename: Ayako
authors.initials: A
authors.lastname: Nishino
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Horai
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Koga
authors.forename: Shin-ya
authors.initials: SY
authors.lastname: Kawashiri
authors.forename: Naoki
authors.initials: N
authors.lastname: Iwamoto
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Hirai
authors.forename: Mami
authors.initials: M
authors.lastname: Tamai
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Sato
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Aramaki
authors.forename: Nozomi
authors.initials: N
authors.lastname: Iwanaga
authors.forename: Yasumori
authors.initials: Y
authors.lastname: Izumi
authors.forename: Tomoki
authors.initials: T
authors.lastname: Origuchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Ueki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D000328:Adult; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013625:Takayasu Arteritis / Q000150:complications* / Q000175:diagnosis