title: Angiogenesis Markers in Gynecological Tumors and Patents for Anti-Angiogenic Approach: Review.
abstract: The formation of a tumor-associated vascular network is an important step in understanding the stages of tumor progression. This review aims to highlight the main markers of induction, proliferation and inhibition of angiogenesis, as well as the quantification of microvessel density, correlated with preclinical and clinical research in gynecologic cancers and also discussed related patents. Studies show that in the most advanced cases of gynecological cancers, biomarkers such as VEGF (Vascular Endothelial Growth Factor), MMP (Matrix Metalloproteinase), CD105 (Endoglin), TIMP (tissue inhibitors of metalloproteinases) and VASH (Vasohibin) are more expressed compared to healthy individuals. Continuous evaluation of these biomarkers in cancer cases could serve in the future as a basis for development of new therapeutic approaches, leading to a good response to cancer treatment, and thus increase survival of cancer patients.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Abdalla
authors.forename: Cindy
authors.initials: C
authors.lastname: Simoens
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Bogers
authors.forename: Eddie F C
authors.initials: EF
authors.lastname: Murta
authors.affiliation: Oncology Research Institute (IPON)/Discipline of Immunology, Federal University of the Triangulo Mineiro (UFTM), Avenida Guilherme Ferreira n° 1940 Uberaba (MG), Brazil, CEP 38100-000, Bairro Sao Benedito. michelinimuno@icbn.uftm.edu.br.
authors.forename: Marcia A
authors.initials: MA
authors.lastname: Michelin
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000098:blood supply / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000503:physiopathology; D010051:Ovarian Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000503:physiopathology; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D020533:Angiogenesis Inhibitors; D014408:Biomarkers, Tumor