title: Posterior Reversible Encephalopathy Syndrome in Early-Stage Breast Cancer.
abstract: Wider use of chemotherapy and targeted agents can be associated with posterior reversible encephalopathy syndrome (PRES). This syndrome is most commonly found in metastatic adenocarcinoma treated with platinum-based analogs and is managed with cessation of the precipitating medication. We present the first case of PRES in early-stage breast cancer and discuss the further management of this condition. Recognition of this condition and correction of identifiable precipitating factor including cessation of relevant medications remains important in its management.
authors.affiliation: Cancer Care Services, Redcliffe Hospital, Redcliffe, Queensland, Australia.|University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Rahul
authors.initials: R
authors.lastname: Ladwa
authors.affiliation: Cancer Care Services, Redcliffe Hospital, Redcliffe, Queensland, Australia.|University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Peters
authors.affiliation: Cancer Care Services, Redcliffe Hospital, Redcliffe, Queensland, Australia.|University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Kieron
authors.initials: K
authors.lastname: Bigby
authors.affiliation: Cancer Care Services, Redcliffe Hospital, Redcliffe, Queensland, Australia.|University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Boris
authors.initials: B
authors.lastname: Chern
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D016190:Carboplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D043823:Taxoids / Q000008:administration & dosage; D000068878:Trastuzumab / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; D000068878:Trastuzumab
keywords: early-stage breast cancer; platinum chemotherapy; posterior reversible encephalopathy syndrome