title: Direct Antiglobulin Test Positivity in Children With Acute Lymphoblastic Leukemia at Diagnosis.
abstract: Direct antiglobulin test positivity had been reported in the course of some lymphoproliferative neoplasms. However, there are a few case reports describing direct antiglobulin test (DAT) positivity in children with acute lymphoblastic leukemia (ALL). We herein report 8 patients who had positive DAT among 95 newly diagnosed children with ALL. None of these patients had evidence of hemolysis during the follow-up. An antibody was detected in 2 of 8 patients with positive DAT. These 2 children also had positive indirect antiglobulin test (IAT); an autoantibody that was reactive at 4°C, and an alloantibody (anti E) that was reactive at 37°C was detected. We believe DAT positivity in ALL without significant hemolysis is not a rare disorder, and a need for further prospective studies is apparent.
authors.affiliation: a Department of Pediatric Hematology , Ankara Children's Hematology and Oncology Hospital , Ankara , Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Gurlek Gokcebay
authors.affiliation: a Department of Pediatric Hematology , Ankara Children's Hematology and Oncology Hospital , Ankara , Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Kara
authors.affiliation: a Department of Pediatric Hematology , Ankara Children's Hematology and Oncology Hospital , Ankara , Turkey.
authors.forename: Ikbal
authors.initials: I
authors.lastname: Ok Bozkaya
authors.affiliation: a Department of Pediatric Hematology , Ankara Children's Hematology and Oncology Hospital , Ankara , Turkey.
authors.forename: Vildan
authors.initials: V
authors.lastname: Culha
authors.affiliation: a Department of Pediatric Hematology , Ankara Children's Hematology and Oncology Hospital , Ankara , Turkey.
authors.forename: Nese
authors.initials: N
authors.lastname: Yarali
authors.affiliation: a Department of Pediatric Hematology , Ankara Children's Hematology and Oncology Hospital , Ankara , Turkey.
authors.forename: Bahattin
authors.initials: B
authors.lastname: Tunc
authors.affiliation: a Department of Pediatric Hematology , Ankara Children's Hematology and Oncology Hospital , Ankara , Turkey.
authors.forename: Namik
authors.initials: N
authors.lastname: Ozbek
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003298:Coombs Test; D005260:Female; D005500:Follow-Up Studies; D006461:Hemolysis; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000175:diagnosis*; D012189:Retrospective Studies
chemical_list: D007518:Isoantibodies
keywords: ALL; Coombs test; children; direct antiglobulin test