title: Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging.
abstract: A major task of contemporary cognitive neuroscience of aging is to explain why episodic memory declines. Change in resting-state functional connectivity (rsFC) could be a mechanism accounting for reduced function. We addressed this through 3 studies. In study 1, 119 healthy participants (20-83 years) were followed for 3.5 years with verbal recall testing and magnetic resonance imaging. Independent of atrophy, recall change was related to change in rsFC in anatomically widespread areas. Striking age-effects were observed in that a positive relationship between rsFC and memory characterized older participants while a negative relationship was seen among the younger and middle-aged. This suggests that cognitive consequences of rsFC change are not stable across age. In study 2 and 3, the age-dependent differences in rsFC-memory relationship were replicated by use of a simulation model (study 2) and by a cross-sectional experimental recognition memory task (study 3). In conclusion, memory changes were related to altered rsFC in an age-dependent manner, and future research needs to detail the mechanisms behind age-varying relationships.
authors.affiliation: Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Physical medicine and rehabilitation, Unit of Neuropsychology, Oslo University Hospital, Oslo, Norway. Electronic address: andersmf@psykologi.uio.no.
authors.forename: Anders M
authors.initials: AM
authors.lastname: Fjell
authors.affiliation: Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
authors.forename: Markus H
authors.initials: MH
authors.lastname: Sneve
authors.affiliation: Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
authors.forename: Håkon
authors.initials: H
authors.lastname: Grydeland
authors.affiliation: Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
authors.forename: Andreas B
authors.initials: AB
authors.lastname: Storsve
authors.affiliation: Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
authors.forename: Ann-Marie Glasø
authors.initials: AG
authors.lastname: de Lange
authors.affiliation: Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
authors.forename: Inge K
authors.initials: IK
authors.lastname: Amlien
authors.affiliation: Ragnar Frisch Centre for Economic Research, Oslo, Norway.
authors.forename: Ole J
authors.initials: OJ
authors.lastname: Røgeberg
authors.affiliation: Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Physical medicine and rehabilitation, Unit of Neuropsychology, Oslo University Hospital, Oslo, Norway.
authors.forename: Kristine B
authors.initials: KB
authors.lastname: Walhovd
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology* / Q000502:physiology / Q000523:psychology*; D001284:Atrophy; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology*; D003071:Cognition; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D011939:Mental Recall; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology* / Q000503:physiopathology*; D009483:Neuropsychological Tests; D055815:Young Adult
keywords: Aging; Atrophy; Default mode network; Episodic memory; Functional connectivity; Resting-state