title: Is there an association between invasive lobular carcinoma of the breast and a family history of gastric cancer?
abstract: CDH1 gene mutations have been found to be associated with diffuse type gastric cancer and invasive lobular carcinoma (ILC) of the breast. To the best of our knowledge, this is the only study relating a family history of gastric cancer to ILC of the breast. We conducted a retrospective study comparing the family history of malignancies in patients with invasive ductal carcinoma (IDC) of the breast and ILC treated in our Medical Center. The comparison was evaluated in both types of breast cancer groups, dividing the patients into two age groups, <50 and ≥50 years. One thousand one hundred and sixty-seven patients with IDC and ILC entered the study. A family history of malignancies was reported in 21.6 % of patients with IDC as opposed to 37.8 % of patients with ILC (P < 0.001). A history of gastric cancer was reported in 7.2 % in the ILC group as compared to 2.3 % in the IDC group, P < 0.008. A family history of breast cancer was more common in the ILC group as opposed to the IDC group, 18 versus 8.1 % respectively, P = 0.002 and persisted in both age groups. We conclude that a family history of malignancies in first degree relatives is more common in patients with ILC than IDC and that there is a significant association between a family history of gastric cancer and ILC.
authors.affiliation: Division of Surgery, Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel.
authors.forename: Bar
authors.initials: B
authors.lastname: Chikman
authors.affiliation: Department of Diagnostic Imaging, The Chaim Sheba Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.
authors.forename: Tima
authors.initials: T
authors.lastname: Davidson
authors.affiliation: Division of Surgery, Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kais
authors.affiliation: Division of Surgery, Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel.
authors.forename: Igor
authors.initials: I
authors.lastname: Jeroukhimov
authors.affiliation: The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ari
authors.initials: A
authors.lastname: Leshno
authors.affiliation: Institute of Pathology, Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel.
authors.forename: Judith
authors.initials: J
authors.lastname: Sandbank
authors.affiliation: Division of Surgery, Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel. fredricag@asaf.health.gov.il.
authors.forename: Ariel
authors.initials: A
authors.lastname: Halevy
authors.affiliation: Division of Surgery, Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel.
authors.forename: Ron
authors.initials: R
authors.lastname: Lavy
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000235:genetics; D018275:Carcinoma, Lobular / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D010375:Pedigree; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics
keywords: Family history; Gastric cancer; Invasive carcinoma of no special type; Invasive lobular carcinoma