title: Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review.
abstract: We herein report the case of a 66-year-old Japanese man with acute-onset type 1 diabetes mellitus (T1D) accompanied by pernicious anemia. After 2 weeks of polyuria, the patient developed insulin-deficient hyperglycemia with diabetic ketoacidosis in the absence of verifiable islet-related autoantibodies and began insulin therapy in 2001. Eight years later, he developed gastric autoantibody-positive pernicious anemia and began methylcobalamin treatment. Previous studies have reported cases of slowly progressive autoimmune T1D concomitant with pernicious anemia. The present case suggests that potential associations with organ-specific autoimmune disorders should be considered during the long-term follow-up of T1D patients, even though verifiable islet-related autoantibodies are undetectable.
authors.affiliation: Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan.
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Ohara
authors.forename: Masanori
authors.initials: M
authors.lastname: Kaneko
authors.forename: Toshio
authors.initials: T
authors.lastname: Yano
authors.forename: Naoko
authors.initials: N
authors.lastname: Sato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Usuda
authors.forename: Masashi
authors.initials: M
authors.lastname: Miyakoshi
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Furukawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Koike
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kaneko
authors.forename: Kyuzi
authors.initials: K
authors.lastname: Kamoi
mesh_terms: D000368:Aged; D000752:Anemia, Pernicious / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D044466:Asian People; D001323:Autoantibodies / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology; D016883:Diabetic Ketoacidosis / Q000209:etiology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D008297:Male; D013270:Stomach / Q000276:immunology; D014805:Vitamin B 12 / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; C019476:mecobalamin; D014805:Vitamin B 12