title: Involvement of Adult Hippocampal Neurogenesis in Learning and Forgetting.
abstract: Adult hippocampal neurogenesis is a process involving the continuous generation of newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested that hippocampal neurogenesis contributes to some forms of hippocampus-dependent learning and memory; however, the detailed mechanism concerning how this small number of newborn neurons could affect learning and memory remains unclear. In this review, we discuss the relationship between adult-born neurons and learning and memory, with a highlight on recently discovered potential roles of neurogenesis in pattern separation and forgetting.
authors.affiliation: State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong ; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada V8P 5C2.
authors.forename: Suk-yu
authors.initials: SY
authors.lastname: Yau
authors.affiliation: State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong ; Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China ; Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou 510632, China ; Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.affiliation: State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong ; Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China ; Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou 510632, China ; Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
authors.forename: Kwok-Fai
authors.initials: KF
authors.lastname: So
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000166:cytology* / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*