title: Nanorings from Concatemeric DNA: Chemical Modification Drives Nanostructure Formation.
abstract: Self-assembly of DNA concatemers from native duplexes and those containing non-nucleotidic bridges of varying polarity composed of repeating oligo(ethylene glycol) phosphates -O(CH2CH2O)(n)PO2- or α,Ω-alkanediol phosphates -O(CH2)10OPO2(-)- units was compared. The structures obtained were characterised by polyacrylamide gel electrophoresis, enzymatic digestion and AFM. Our results have revealed that chemically-modified duplexes favour self-termination of concatemer growth and yield up to 35% of nanosized DNA rings.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Vinogradova
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Lomzov
authors.forename: Georgiy Yu
authors.initials: GY
authors.lastname: Shevelev
authors.forename: Dmitrii V
authors.initials: DV
authors.lastname: Sheglov
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Latyshev
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Stetsenko
authors.forename: Dmitrii V
authors.initials: DV
authors.lastname: Pyshnyi
mesh_terms: D001483:Base Sequence; D044708:DNA, Concatenated / Q000737:chemistry* / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism; D019855:Ethylene Glycol / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry*; D009841:Oligonucleotides
chemical_list: D044708:DNA, Concatenated; D009841:Oligonucleotides; D003851:Deoxyribonucleases; D019855:Ethylene Glycol