title: Regioselective Green Electrochemical Approach to the Synthesis of Nitroacetaminophen Derivatives.
abstract: A regioselective green synthesis of nitroacetaminophen derivatives was carried out by electrochemical oxidation of acetaminophen, N-(2-hydroxyphenyl)acetamide, and 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of nitrite ion as a nucleophile. The present work has led to the development of a reagentless green and facile electrochemical method for the synthesis of some nitroacetaminophen derivatives.
authors.affiliation: Faculty of Chemistry, Bu-Ali-Sina University , Hamedan 65174, Iran.
authors.forename: Eslam
authors.initials: E
authors.lastname: Salahifar
authors.affiliation: Faculty of Chemistry, Bu-Ali-Sina University , Hamedan 65174, Iran.
authors.forename: Davood
authors.initials: D
authors.lastname: Nematollahi
authors.affiliation: Faculty of Chemistry, Bu-Ali-Sina University , Hamedan 65174, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Bayat
authors.affiliation: Faculty of Chemistry, Bu-Ali-Sina University , Hamedan 65174, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Mahyari
authors.affiliation: Department of Chemistry, University of Isfahan , Isfahan 81746-73441, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Amiri Rudbari
mesh_terms: D000082:Acetaminophen / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000083:Acetanilides / Q000737:chemistry; D015394:Molecular Structure; D009566:Nitrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010879:Piperazines / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C581531:1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone; D000083:Acetanilides; D009566:Nitrates; D010879:Piperazines; D000082:Acetaminophen; C047799:2-hydroxyacetanilide; C478738:4-(nitroxy)butanoic acid 4-acetylaminophenyl ester