title: Upregulation of des-gamma-carboxy-prothrombin after portal vein embolization in a cirrhotic patient with hepatocellular carcinoma.
abstract: A 73-year-old female with hepatocellular carcinoma (HCC) received percutaneous transhepatic portal vein embolization (PTPE) before extensive right lobe hepatectomy. Serum levels of des-gamma-carboxy-prothrombin (DCP) were increased and remained at a high level until hepatectomy. Immunohistochemical examination revealed that an increased expression of DCP was demonstrated not only in HCC tissues, but also in the non-cancerous liver of the right lobe, where portal blood flow was blocked off as a result of PTPE. The serum level of DCP is known to be greatly increased in patients with HCC accompanied by portal vein invasion. We speculate that this increased DCP level is caused by both increased DCP production in HCC tissue and the surrounding non-cancerous liver, where portal flow is blocked off as a result of portal invasion by HCC.
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. tetsuro@fukuoka-u.ac.jp.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sohda
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Iwata
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Anan
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Kunimoto
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yotsumoto
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Yokoyama
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Morihara
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Takeyama
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shakado
authors.affiliation: Department of Radiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Akinobu
authors.initials: A
authors.lastname: Osame
authors.affiliation: Department of Radiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kora
authors.affiliation: Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Ohishi
authors.affiliation: Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yamauchi
authors.affiliation: Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Noritomi
authors.affiliation: Department of Radiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Yoshimitsu
authors.affiliation: Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamashita
authors.affiliation: Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Sakisaka
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000628:therapy*; D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis; D008113:Liver Neoplasms / Q000378:metabolism / Q000628:therapy*; D009361:Neoplasm Invasiveness; D011169:Portal Vein; D011498:Protein Precursors / Q000097:blood / Q000378:metabolism*; D011516:Prothrombin / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; C008208:acarboxyprothrombin; D011516:Prothrombin
keywords: Des-gamma-carboxy-prothrombin; Hepatocellular carcinoma; Immunohistochemistry; Percutaneous transhepatic portal vein embolization