title: The effect of vitamin E on lung pathology in sulfur mustard-exposed guinea pigs.
abstract: Pulmonary complications of exposure to sulfur mustard (SM) gas range from no effect or mild symptoms to severe bronchial stenosis. In the present study, the protective effect of vitamin E on the lung inflammation of SM-exposed guinea pigs was examined. Guinea pigs (n = 5 for each group) were exposed to ethanol (control group), 40 mg/m3inhaled SM (SME group), SME treated with vitamin E (SME + E), SME treated with dexamethasone (SME + D), and SME treated with both treatments (SME + E + D). Pathological evaluation of the lung was done 14 days postexposure. The epithelial desquamation of trachea and other pathologic changes in the lung of the SME group were significantly higher than those in the control group. Furthermore, the pathological changes of trachea and lung in the SME + E and SME + E + D groups were significantly improved compared with those of SME group. In addition, the pathological changes of trachea and lung of SME + E and SME + E + D animals were significantly less than those of SME + D group.
authors.affiliation: Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Gholamnezhad
authors.affiliation: Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran boskabadymh@mums.ac.ir.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Boskabady
authors.affiliation: Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
authors.forename: Sediqa
authors.initials: S
authors.lastname: Amery
authors.affiliation: Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
authors.forename: Nassim
authors.initials: N
authors.lastname: Vahedi
authors.affiliation: Department of Pathology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
authors.forename: Abass
authors.initials: A
authors.lastname: Tabatabaei
authors.affiliation: Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Boskabady
authors.affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Shahriary
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D000431:Ethanol / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009151:Mustard Gas / Q000633:toxicity*; D014132:Trachea / Q000187:drug effects / Q000473:pathology; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D014810:Vitamin E; D000431:Ethanol; D003907:Dexamethasone; D009151:Mustard Gas
keywords: Lung pathology; dexamethasone; sulfur mustard; vitamin E