title: Biomarkers for Primary Sjögren's Syndrome.
abstract: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of pSS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. Screening noninvasive biomarkers from the saliva and tears has significant potential. The need for specific and sensitive biomarker candidates in pSS is significant. This review aims to summarize recent advances in the identification of biomarkers of Sjögren syndrome, trying to identify reliable, sensitive, and specific biomarkers that can be used to guide treatment decisions.
authors.affiliation: Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; Division of Rheumatology, Penn State University Hershey College of Medicine, Hershey, PA 17033, USA.
authors.forename: Weiqian
authors.initials: W
authors.lastname: Chen
authors.affiliation: Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Cao
authors.affiliation: Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: linjzj@hotmail.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Lin
authors.affiliation: Division of Rheumatology, Penn State University Hershey College of Medicine, Hershey, PA 17033, USA.
authors.forename: Nancy
authors.initials: N
authors.lastname: Olsen
authors.affiliation: Division of Rheumatology, Penn State University Hershey College of Medicine, Hershey, PA 17033, USA. Electronic address: szheng1@hmc.psu.edu.
authors.forename: Song Guo
authors.initials: SG
authors.lastname: Zheng
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D013666:Tears / Q000737:chemistry / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D007370:Interferon Type I; D008565:Membrane Proteins; C084881:flt3 ligand protein
keywords: Biomarker; Fms-like tyrosine kinase 3 ligand; Myxovirus-resistance protein A; Non-coding RNAs; Saliva; Sjögren syndrome