title: [The relationship between neuroendocrine dysfunction and free-radical oxidation in old age alcoholism].
abstract: OBJECTIVE
  to study the relationship between dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and free-radical oxidation in old age alcoholism.
  
  
  METHODS
  Authors examined 46 men and women, aged 60-80 years, with alcoholism. Contents of cortisol, lipid peroxidation products and the level of an oxidatively modified protein were measured.
  
  
  CONCLUSIONS
  A decrease in blood cortisol content and correlations between its level and activity of free-radical oxidation were identified. The severity of neuroendocrine dysfunction in old patients was sex-related. It has been suggested that the impairment of HPA system activity may be a cause of oxidative stress and development of alcoholism.
authors.affiliation: Chelyabinsk Regional Clinical Narcological Hospital Drug, Chelyabinsk.
authors.forename: D B
authors.initials: DB
authors.lastname: Vinogradov
authors.affiliation: South Ural State Medical University, Chelyabinsk.
authors.forename: A Kh
authors.initials: AK
authors.lastname: Mingazov
authors.affiliation: South Ural State University, Chelyabinsk.
authors.forename: I V
authors.initials: IV
authors.lastname: Izarovskaya
authors.affiliation: Chelyabinsk Regional Clinical Narcological Hospital Drug, Chelyabinsk.
authors.forename: K A
authors.initials: KA
authors.lastname: Babin
authors.affiliation: South Ural State Medical University, Chelyabinsk.
authors.forename: A I
authors.initials: AI
authors.lastname: Sinitsky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000097:blood / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010913:Pituitary-Adrenal System / Q000503:physiopathology*
chemical_list: D005609:Free Radicals; D006854:Hydrocortisone