title: Switchable Reconfiguration of a Seven-Ring Interlocked DNA Catenane Nanostructure.
abstract: The synthesis, purification, and structure characterization of a seven-ring interlocked DNA catenane is described. The design of the seven-ring catenane allows the dynamic reconfiguration of any of the four rings (R1, R3, R4, and R6) on the catenane scaffold, or the simultaneous switching of any combination of two, three, or all four rings to yield 16 different isomeric states of the catenane. The dynamic reconfiguration across the states is achieved by implementing the strand-displacement process in the presence of appropriate fuel/antifuel strands and is probed by fluorescence spectroscopy. Each of the 16 isomers of the catenane can be transformed into any of the other isomers, thus allowing for 240 dynamic transitions within the system.
authors.affiliation: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lu
authors.affiliation: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cecconello
authors.affiliation: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.|The Key Laboratory of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry, Fuzhou University , Fuzhou 350002, China.
authors.forename: Xiu-Juan
authors.initials: XJ
authors.lastname: Qi
authors.affiliation: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
authors.forename: Na
authors.initials: N
authors.lastname: Wu
authors.affiliation: Kekulé Institut für Organische Chemie und Biochemie, University of Bonn , Gerhard-Domagk-Straße 1, 53121 Bonn, Germany.
authors.forename: Stefan-Sven
authors.initials: SS
authors.lastname: Jester
authors.affiliation: LIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn , Gerhard-Domagk-Straße 1, 53121 Bonn, Germany.|Center of Advanced European Studies and Research (CAESAR) , Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Famulok
authors.affiliation: Cluster of Excellence Centre for Advancing Electronics Dresden (cfaed), Technische Universität Dresden , 01062 Dresden, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Matthies
authors.affiliation: Cluster of Excellence Centre for Advancing Electronics Dresden (cfaed), Technische Universität Dresden , 01062 Dresden, Germany.
authors.forename: Thorsten-Lars
authors.initials: TL
authors.lastname: Schmidt
authors.affiliation: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
authors.forename: Itamar
authors.initials: I
authors.lastname: Willner
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D007536:Isomerism; D049329:Nanostructures
chemical_list: D000873:Anthracenes; C467767:catenane; D004247:DNA
keywords: Nanobiotechnology; fluorescence; machine; strand displacement; switch