title: Quantitative analysis of the capillary network of aged APPswe/PS1dE9 transgenic mice.
abstract: A combination of immunohistochemical and stereological techniques were used to investigate the capillary network in the cerebral cortex of 18-month-old APPswe/PS1dE9 transgenic (Tg) mice and control littermates. Data regarding total capillary length, segment number, diffusion radius, and pericyte number are presented. The total length was 60 meters and there was a one-to-one relationship between the number of capillary segments and pericytes in both groups. Significant differences were not observed in the Tg and wild-type controls indicating that the Alzheimer's-like amyloidosis produced in this Tg mouse has a minimal affect on the structural integrity of the cerebral capillary network.
authors.affiliation: Department of Biomedicine, Aarhus University, Aarhus C, Denmark. Electronic address: gnn@biomed.au.dk.
authors.forename: Gitte Nykjær
authors.initials: GN
authors.lastname: Nikolajsen
authors.affiliation: Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
authors.forename: Kamila Anna
authors.initials: KA
authors.lastname: Kotynski
authors.affiliation: Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
authors.forename: Morten Skovgaard
authors.initials: MS
authors.lastname: Jensen
authors.affiliation: Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: West
mesh_terms: D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000209:etiology / Q000473:pathology; D000686:Amyloidosis / Q000209:etiology / Q000473:pathology; D000818:Animals; D002196:Capillaries / Q000473:pathology*; D002540:Cerebral Cortex / Q000098:blood supply*; D005260:Female; D008822:Mice, Transgenic; D020286:Pericytes / Q000473:pathology
keywords: Alzheimer; Amyloidosis; Capillaries; Pericytes; Stereology