title: BMI Affects the Relationship between Long Chain N-3 Polyunsaturated Fatty Acid Intake and Stroke Risk: a Meta-Analysis.
abstract: We performed a meta-analysis to clarify the relationship between long chain n-3 polyunsaturated fatty acid (PUFA) intake and stroke risk. Relevant studies were identified by searching online databases through May 2015. Log relative risks (RRs) of the highest versus the lowest for cohort studies were weighed by the inverse variance method to obtain pooled RRs. Fourteen prospective cohort studies including 514,483 individuals and 9,065 strokes were included. The pooled RR of overall stroke risk for long chain n-3 PUFA intake was 0.87 [95% confidence interval (CI), 0.79-0.95]. Stratification analysis showed that higher long chain n-3 PUFAs intake was associated with reduced fatal stroke risk (RR = 0.84; 95% CI, 0.73-0.97), reduced stroke risk for BMI < 24 (RR = 0.86; 95% CI, 0.75-0.98) and reduced stroke risk for females (RR = 0.81; 95% CI, 0.71-0.92), but was not associated with stroke risk for either BMI ≥ 24 or men. This meta-analysis reveals that higher long chain n-3 PUFA intake is inversely associated with risk of stroke morbidity and mortality with BMI and sex as key factors influencing this risk. Individuals should be encouraged to manage their body weight while increasing their intake of long chain n-3 PUFAs.
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.|Chongqing Key Laboratory of Neurobiology, Chongqing, 400016, China.|Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China.|Department of Histology and Embryology, Jiamusi University, Jiamusi, Heilongjiang Province, 154002, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Cheng
authors.affiliation: Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Huang
authors.affiliation: Chongqing Key Laboratory of Neurobiology, Chongqing, 400016, China.|Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China.|Key Laboratory of Medical Diagnostics, Ministry of Education.|Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Shunjie
authors.initials: S
authors.lastname: Bai
authors.affiliation: Chongqing Key Laboratory of Neurobiology, Chongqing, 400016, China.|Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China.|Key Laboratory of Medical Diagnostics, Ministry of Education.|Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Chongqing Key Laboratory of Neurobiology, Chongqing, 400016, China.|Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China.|Key Laboratory of Medical Diagnostics, Ministry of Education.|Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yu
authors.affiliation: Institute of Neuroscience, Jiamusi University, Jiamusi, Heilongjiang Province, 154002, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Jiamusi University, Jiamusi, Heilongjiang Province, 154002, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Qi
authors.affiliation: Department of Respiratory Medicine, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Shao
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.|Chongqing Key Laboratory of Neurobiology, Chongqing, 400016, China.|Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xie
mesh_terms: D015992:Body Mass Index; D004032:Diet; D015525:Fatty Acids, Omega-3; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011446:Prospective Studies; D017594:Publication Bias; D012306:Risk; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology*
chemical_list: D015525:Fatty Acids, Omega-3