title: Sublingual grass and ragweed immunotherapy: Clinical considerations-a PRACTALL consensus report.
abstract: Sublingual allergen immunotherapy provides a new option for patients with allergic rhinitis in the United States. The efficacy of these sublingual immunotherapy tablets in the treatment of allergic rhinitis has been firmly established in large multicenter clinical trials. In addition, the clinical benefits of sublingual immunotherapy might persist after treatment is discontinued. Local reactions, such as gastrointestinal or oropharyngeal symptoms, are common. However, severe anaphylaxis is rare, and therefore the immunotherapy tablets can be administered at home. Sublingual immunotherapy for allergic rhinitis has been used successfully for years in Europe, and these products might be appropriate for patients who do not do well with standard drug therapy or for those who prefer a disease-modifying approach.
authors.affiliation: Division of Allergic Diseases, Mayo Clinic, Rochester, Minn. Electronic address: li.james@mayo.edu.
authors.forename: James T
authors.initials: JT
authors.lastname: Li
authors.affiliation: University of Cincinnati, Cincinnati, Ohio.
authors.forename: David I
authors.initials: DI
authors.lastname: Bernstein
authors.affiliation: Imperial College London, London, United Kingdom.
authors.forename: Moises A
authors.initials: MA
authors.lastname: Calderon
authors.affiliation: University of South Florida, Tampa, Fla.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Casale
authors.affiliation: Nova Southeastern University, Fort Lauderdale, Fla.
authors.forename: Linda
authors.initials: L
authors.lastname: Cox
authors.affiliation: Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Passalacqua
authors.affiliation: Center for Rhinology and Allergology, Wiesbaden, Germany; Department of Otorhinolaryngology, Head and Neck Surgery, Universitatsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Pfaar
authors.affiliation: Allergy Research Center, Athens, Greece.
authors.forename: Nikolaos G
authors.initials: NG
authors.lastname: Papadopoulos
mesh_terms: D000367:Age Factors; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology*; D031164:Ambrosia / Q000009:adverse effects*; D018926:Anti-Allergic Agents / Q000627:therapeutic use; D052179:Antigens, Plant / Q000276:immunology*; D019468:Disease Management; D006801:Humans; D055118:Medication Adherence; D006109:Poaceae / Q000009:adverse effects*; D065631:Rhinitis, Allergic / Q000276:immunology / Q000628:therapy; D063729:Sublingual Immunotherapy / Q000009:adverse effects / Q000379:methods / Q000592:standards; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D018926:Anti-Allergic Agents; D052179:Antigens, Plant
keywords: Sublingual; immunotherapy; ragweed; sublingual immunotherapy