title: Is Gleason Grade 5 Prostate Cancer Resistant to Conventional Androgen Deprivation Therapy?
abstract: Synthesis of data from randomized trials suggests that long-term versus short-term androgen deprivation therapy may be most effective in men with Gleason grade 4 prostate cancer (PCa) and less or ineffective in men with Gleason grade 5 PCa.
authors.affiliation: Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA, USA. Electronic address: adamico@partners.org.
authors.forename: Anthony V
authors.initials: AV
authors.lastname: D'Amico
mesh_terms: D059002:Androgen Receptor Antagonists / Q000627:therapeutic use*; D006801:Humans; D007986:Luteinizing Hormone / Q000819:agonists*; D008297:Male; D060787:Neoplasm Grading; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D011878:Radiotherapy; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate
chemical_list: D059002:Androgen Receptor Antagonists; D007986:Luteinizing Hormone