title: A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer.
abstract: Lung cancer remains the leading common cause of cancer-related death, with non-small-cell lung cancer (NSCLC) accounting for 80% of all cases. To date, platinum-based doublet chemotherapy is the cornerstone of first-line therapy. However, these agents have limited use in patients who have relapsed and have metastatic disease. Therefore, novel strategies are required to improve the clinical outcome. Folate receptor alpha (FRA) is overexpressed in the majority of NSCLC, particularly in lung adenocarcinomas. FRA is largely absent from normal tissue, making it an attractive therapeutic target. In this review, we discuss FRA expression in NSCLC, conjugated FRA agents, monoclonal antibody, and FRA-specific T-cell-based therapeutic strategies aiming to improve the cure rate of FRA-expressing NSCLC.
authors.affiliation: Department of Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, People's Republic of China.
authors.forename: Changzheng
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, People's Republic of China.
authors.forename: Zhehai
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D058975:Folate Receptor 1 / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D008175:Lung Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; C548696:FOLR1 protein, human; D058975:Folate Receptor 1
keywords: folate receptor alpha; immunotherapy; lung cancer