title: Infections on the rise: Raoultella spp., clinical and microbiological findings from a retrospective study, 2010-2014.
abstract: We performed a retrospective analysis of clinical and laboratory data over 5 years in a tertiary centre to assess clinical and microbiological characteristics of patients with Raoultella spp. infection. Raoultella spp. were deemed responsible for clinical infections in 57 patients (R. planticola, n = 32 and R. ornithinolytica, n = 25). The most prevalent diagnoses for R. planticola were cystitis (50%; n = 16) followed by bacteraemia and pneumonia (9.4%; n = 3); for R. ornithinolytica, cystitis (36%; n = 9) followed by pneumonia (24%; n = 6). Immunodeficiency was present in 18 patients (56.3%) with R. planticola and in 16 patients (64%) with R. ornithinolytica infection. Of these, 55.6% and 37.5% had diabetes and 27.8% and 18.% were solid organ transplant recipients, respectively. All isolates were sensitive to third-generation cephalosporins, fluoroquinolones and aminoglycosides. Mortality of infections with R. planticola (n = 5; 15.6%) was higher than for R. ornithinolytica (n = 2; 8.0%), but the difference was not statistically significant.
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.|b NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo dos Mártires da Pátria , 130,1169-056, Lisboa , Portugal.
authors.forename: Matteo
authors.initials: M
authors.lastname: Boattini
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.|b NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo dos Mártires da Pátria , 130,1169-056, Lisboa , Portugal.
authors.forename: André
authors.initials: A
authors.lastname: Almeida
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Cardoso
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.
authors.forename: Cristiano Silva
authors.initials: CS
authors.lastname: Cruz
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Machado
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Vesza
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.
authors.forename: Valentina
authors.initials: V
authors.lastname: Tosatto
authors.affiliation: c Pneumology Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Centra , Lisboa , Portugal.
authors.forename: Dionísio
authors.initials: D
authors.lastname: Maia
authors.affiliation: d Infectious Diseases Department, Hospital Curry Cabral , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.
authors.forename: Sara
authors.initials: S
authors.lastname: Cardoso
authors.affiliation: e Microbiology Department, Hospital Dona Estefania , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.
authors.forename: Margarida
authors.initials: M
authors.lastname: Pinto
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.|b NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo dos Mártires da Pátria , 130,1169-056, Lisboa , Portugal.
authors.forename: Rita Barata
authors.initials: RB
authors.lastname: Moura
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.|b NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo dos Mártires da Pátria , 130,1169-056, Lisboa , Portugal.
authors.forename: Teresa
authors.initials: T
authors.lastname: Garcia
authors.affiliation: a Internal Medicine Department, Hospital Santa Marta , Centro Hospitalar de Lisboa Central , Lisboa , Portugal.|b NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo dos Mártires da Pátria , 130,1169-056, Lisboa , Portugal.
authors.forename: António Sousa
authors.initials: AS
authors.lastname: Guerreiro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000209:etiology; D003556:Cystitis / Q000382:microbiology; D048909:Diabetes Complications / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004755:Enterobacteriaceae / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000382:microbiology; D011174:Portugal / Q000453:epidemiology; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D013997:Time Factors; D066027:Transplant Recipients
chemical_list: D000900:Anti-Bacterial Agents
keywords: Enterobacteriaceae; Raoultella; gram-negative; infection; multiple drug resistance