title: Auditory Function in Immature Animals after Two Consecutive Courses of Ototoxic Antibiotics.
abstract: In chronic experiments on immature rabbits receiving therapeutic courses of vancomycin, gentamicin, and consecutive administration of vancomicin and gentamicin by the scheme used in neonatology, hearing function was evaluated by the methods of auditory evoked potentials (auditory brainstem response, ABR) and distortion product otoacoustic emission (DPOAE). Comparison with the control group revealed ototoxic effects of all studied antibiotics that manifested in increased sound tolerance and more rapid shortening of latencies in 30-100 dB range. Higher thresholds were found only after gentamicin administration. Vancomycin administration significantly reduced the responses at 4 kHz. Subsequent gentamicin course did not potentiate this effect.
authors.affiliation: Department of Physiology, Medico-Biological Faculty, Moscow, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: D'yakonova
authors.affiliation: Department of Pharmacology, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Kamkina
authors.affiliation: Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia. ishanova@hotmail.com.
authors.forename: Yu S
authors.initials: YS
authors.lastname: Ishanova
authors.affiliation: Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Rakhmanova
authors.affiliation: Department of Pediatric Otorhinolaryngology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: D S
authors.initials: DS
authors.lastname: Burmistrova
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D004334:Drug Administration Schedule; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005839:Gentamicins / Q000633:toxicity*; D034381:Hearing Loss / Q000139:chemically induced; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects; D011817:Rabbits; D014640:Vancomycin / Q000633:toxicity*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014640:Vancomycin
keywords: auditory brainstem response (ABR); distortion product otoacoustic emission (DPOAE); gentamicin; immature rabbits; vancomycin