title: Evaluation of lamina cribrosa thickness and depth in ocular hypertension.
abstract: OBJECTIVE
  To investigate the differences in thickness and depth of the lamina cribrosa (LC) between ocular hypertension (OH) patients and normal control subjects, using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  EDI-OCT data were obtained from the subjects in a cross-sectional analysis of data from a retrospective study. After IOP correction according to central corneal thickness (CCT), we divided the OH patients into two groups based on the corrected IOP (cIOP)--OH with lower IOP (OH-L; cIOP < 23 mmHg) and OH with higher IOP (OH-H; cIOP ≥ 23 mmHg). Comparisons of LC thickness and depth among three groups were performed.
  
  
  RESULTS
  Seventy-four OH patients and 45 normal control subjects were included in the analysis. Among the 74 OH patients, 41 were included in the OH-L group and 33 were included in the OH-H group. LC thickness was thicker in the OH-H group compared to normal controls both in superior (P = 0.02) and inferior (P = 0.01) portions. However, no difference was found in LC depth among the three groups in any portion (P = 0.36; P = 0.44; P = 0.31, respectively).
  
  
  CONCLUSIONS
  OH patients may have a thicker LC than normal control subjects, especially in OH with definite high IOP.
authors.affiliation: Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, Korea.
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Han
authors.affiliation: Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, Korea.
authors.forename: Da-Ye
authors.initials: DY
authors.lastname: Choi
authors.affiliation: Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, Korea.
authors.forename: Young Kyo
authors.initials: YK
authors.lastname: Kwun
authors.affiliation: Department of Ophthalmology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Wool
authors.initials: W
authors.lastname: Suh
authors.affiliation: Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, Korea. ckee@skku.edu.
authors.forename: Changwon
authors.initials: C
authors.lastname: Kee
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D015588:Observer Variation; D009798:Ocular Hypertension / Q000150:complications* / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology*; D009929:Organ Size; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence
keywords: Lamina cribrosa; Lamina cribrosa thickness; Ocular hypertension; Optical coherence tomography