title: MCP-1 and soluble TWEAK levels are independently associated with coronary artery disease severity in patients with chronic kidney disease.
abstract: OBJECTIVE
  Patients diagnosed with chronic kidney disease (CKD) have a greater rate of cardiovascular mortality when compared with the general population. The soluble form of TNF-like weak inducer of apoptosis (TWEAK) and monocyte chemoattractan protein 1 (MCP-1) play important roles in cellular proliferation, migration and apoptosis. The current study aimed to analyze whether soluble TWEAK (sTWEAK) and MCP-1 levels are associated with the severity of coronary arterial disease (CAD) in CKD patients.
  
  
  METHODS
  Ninety-seven patients diagnosed with CKD stages 2-3 according to their estimated glomerular filtration rate and the presence of kidney injury were included in the study. Plasma sTWEAK and MCP-1 concentrations were determined using commercially available ELISA kits. Coronary angiographies were performed through femoral artery access using the Judkins technique.
  
  
  RESULTS
  Correlation analysis of sTWEAK and Gensini scores showed significant association (p < 0.01, r(2) = 0.287). Also significant correlation has been found in MCP-1 levels and Gensini scores (p < 0.01, r(2) = 0.414). When patients were divided into two groups with a limit of 17 according to their Gensini score, sTWEAK levels indicated a statistically significant difference (p < 0.01).
  
  
  CONCLUSIONS
  Our findings support a relationship between sTWEAK and MCP-1 levels and CAD in CKD stages 2-3 patients.
authors.affiliation: a Department of Internal Medicine , Haydarpaşa Numune Education and Research Hospital , Istanbul , Turkey .
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Akdoğan
authors.affiliation: b Department of Nephrology , Ankara Education and Research Hospital , Ankara , Turkey .
authors.forename: Alper
authors.initials: A
authors.lastname: Azak
authors.affiliation: c Department of Nephrology , Haydarpaşa Numune Education and Research Hospital , Istanbul , Turkey .
authors.forename: Nazım
authors.initials: N
authors.lastname: Denizli
authors.affiliation: b Department of Nephrology , Ankara Education and Research Hospital , Ankara , Turkey .
authors.forename: Bülent
authors.initials: B
authors.lastname: Huddam
authors.affiliation: b Department of Nephrology , Ankara Education and Research Hospital , Ankara , Turkey .
authors.forename: Gülay
authors.initials: G
authors.lastname: Koçak
authors.affiliation: c Department of Nephrology , Haydarpaşa Numune Education and Research Hospital , Istanbul , Turkey .
authors.forename: Murat
authors.initials: M
authors.lastname: Gücün
authors.affiliation: d Department of Cardiology , Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center , Istanbul , Turkey , and.
authors.forename: Mustafa Adem
authors.initials: MA
authors.lastname: Tatlısu
authors.affiliation: c Department of Nephrology , Haydarpaşa Numune Education and Research Hospital , Istanbul , Turkey .
authors.forename: Recep
authors.initials: R
authors.lastname: Demirci
authors.affiliation: c Department of Nephrology , Haydarpaşa Numune Education and Research Hospital , Istanbul , Turkey .
authors.forename: Bilal
authors.initials: B
authors.lastname: Yılmaz
authors.affiliation: c Department of Nephrology , Haydarpaşa Numune Education and Research Hospital , Istanbul , Turkey .
authors.forename: Mehmet
authors.initials: M
authors.lastname: Dikeç
authors.affiliation: e Department of Biochemistry , Haydarpaşa Numune Education and Research Hospital , Istanbul , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Bakırtaş
authors.affiliation: b Department of Nephrology , Ankara Education and Research Hospital , Ankara , Turkey .
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Akdağ
authors.affiliation: b Department of Nephrology , Ankara Education and Research Hospital , Ankara , Turkey .
authors.forename: Murat
authors.initials: M
authors.lastname: Duranay
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis*; D000074049:Cytokine TWEAK; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012720:Severity of Illness Index; D048069:Tumor Necrosis Factors / Q000097:blood*
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D000074049:Cytokine TWEAK; C109743:TNFSF12 protein, human; D048069:Tumor Necrosis Factors
keywords: Chronic kidney disease; Gensini score; MCP-1; TWEAK; coronary arterial disease