title: Circulating Tumor Cells and Recurrence After Primary Systemic Therapy in Stage III Inflammatory Breast Cancer.
abstract: Inflammatory breast cancer (IBC) is rare and aggressive, with poor survival. While circulating tumor cells (CTCs) predict outcome in non-IBC patients, little data exists regarding their prognostic significance in IBC. This prospective study analyzed blood samples for CTCs from 63 stage III IBC patients to determine if CTCs present after primary systemic chemotherapy predicted relapse. CTC identification was not associated with tumor characteristics, lymph node positivity, or complete pathologic response to systemic therapy. At mean follow-up of 38 months, multivariable analysis demonstrated that detection of one or more CTCs predicted shortened relapse-free (log-rank P = 0.005, hazard ratio [HR] = 4.22, 95% confidence interval [CI] = 1.67 to 10.67, Cox P = 0.002) but not overall survival (log-rank P = 0.54, HR = 1.53, 95% CI = 0.41 to 5.79, Cox P = 0.53). All statistical tests were two-sided. In this study, CTCs after primary chemotherapy identified IBC patients at high risk for relapse.
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Carolyn S
authors.initials: CS
authors.lastname: Hall
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Mandar
authors.initials: M
authors.lastname: Karhade
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Laubacher
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Henry M
authors.initials: HM
authors.lastname: Kuerer
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Savitri
authors.initials: S
authors.lastname: Krishnamurthy
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Sarah
authors.initials: S
authors.lastname: DeSnyder
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Amber E
authors.initials: AE
authors.lastname: Anderson
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Vicente
authors.initials: V
authors.lastname: Valero
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Naoto T
authors.initials: NT
authors.lastname: Ueno
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX.
authors.forename: Xiao
authors.initials: X
authors.lastname: Su
authors.affiliation: Departments of Surgical Oncology (CSH, MK, BAL, HMK, SD, AEA, AL), Surgical Pathology (SK), Breast Medical Oncology (VV, NTU), and Biostatistics (LY, SX), The University of Texas MD Anderson Cancer Center, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, TX. alucci@mdanderson.org.
authors.forename: Anthony
authors.initials: A
authors.lastname: Lucci
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D058922:Inflammatory Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating; D016017:Odds Ratio; D016016:Proportional Hazards Models; D011446:Prospective Studies