title: Emerging strategies for cancer immunoprevention.
abstract: The crucial role of the immune system in the formation and progression of tumors has been widely accepted. On one hand, the surveillance role of the immune system plays an important role in endogenous tumor prevention, but on the other hand, in some special circumstances such as in chronic inflammation, the immune system can actually contribute to the formation and progression of tumors. In recent years, there has been an explosion of novel targeted immunotherapies for advanced cancers. In the present manuscript, we explore known and potential various types of cancer prevention strategies and focus on nonvaccine-based cancer preventive strategies targeting the immune system at the early stages of tumorigenesis.
authors.affiliation: Department of Oncology. Johns Hopkins University. Maryland, MD, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Roeser
authors.affiliation: The David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Leach
authors.affiliation: Department of Clinical Cancer Prevention. The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: F
authors.initials: F
authors.lastname: McAllister
mesh_terms: D018890:Chemoprevention; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D053590:Interleukin 1 Receptor Antagonist Protein / Q000502:physiology; D016209:Interleukin-8 / Q000037:antagonists & inhibitors; D015166:Monitoring, Immunologic; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control*; D061026:Programmed Cell Death 1 Receptor / Q000502:physiology; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology; D000093242:Interleukin-6 Inhibitors
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D016209:Interleukin-8; D061026:Programmed Cell Death 1 Receptor; D050796:STAT3 Transcription Factor; D000093242:Interleukin-6 Inhibitors; C105992:PDCD1 protein, human