title: Collapse and hybridization of RNA: view from replica technique approach.
abstract: The replica technique method is applied to investigate the kinetic behavior of the coarse-grained model for the RNA molecule. A non-equilibrium phase transition of second order between the glassy phase and the ensemble of freely fluctuating structures has been observed. The non-equilibrium steady state is investigated as well and the thermodynamic characteristics of the system have been evaluated. The non-equilibrium behavior of the specific heat is discussed. Based on our analysis, we point out the state in the kinetic pathway in which the RNA molecule is most prone to hybridization.
authors.affiliation: Yerevan State University, 1 A. Manoogian Str., 0025, Yerevan, Armenia.
authors.forename: Y Sh
authors.initials: YSh
authors.lastname: Mamasakhlisov
authors.affiliation: INFN-Laboratori Nazionali di Frascati, Via Enrico Fermi, 40, 00044, Frascati RM, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bellucci
authors.affiliation: Institute of Physics, Academia Sinica, 128 Sec. 2, Academia Rd., 11529, Nankang, Taipei, Taiwan.
authors.forename: Shura
authors.initials: S
authors.lastname: Hayryan
authors.affiliation: Yerevan State University, 1 A. Manoogian Str., 0025, Yerevan, Armenia.
authors.forename: H
authors.initials: H
authors.lastname: Caturyan
authors.affiliation: Goris State University, 4 Avangard Str., 3204, Goris, Armenia.
authors.forename: Z
authors.initials: Z
authors.lastname: Grigoryan
authors.affiliation: Institute of Physics, Academia Sinica, 128 Sec. 2, Academia Rd., 11529, Nankang, Taipei, Taiwan. huck@phys.sinica.edu.tw.|National Center for Theoretical Sciences, National Tsing Hua University, 30013, Hsinchu, Taiwan. huck@phys.sinica.edu.tw.|Business School, University of Shanghai for Science and Technology, 200093, Shanghai, China. huck@phys.sinica.edu.tw.
authors.forename: Chin-Kun
authors.initials: CK
authors.lastname: Hu
mesh_terms: D003198:Computer Simulation; D008956:Models, Chemical; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000737:chemistry* / Q000648:ultrastructure*
chemical_list: D012313:RNA
keywords: Living systems: Biological Matter