title: Multidrug therapy of Mycobacterium avium subsp. avium infection in experimentally inoculated budgerigars (Melopsittacus undulatus).
abstract: The aim of the study was to determine whether the four-month experimental therapy of mycobacteriosis in budgerigars may cause a complete recovery. A group of nine budgerigars was infected with a Mycobacterium avium subsp. avium isolate with proven pathogenicity for budgerigars. Five weeks post-inoculation, multidrug therapy was started. Another group comprising six birds received the same treatment but no infection, and the third group also comprising six birds was kept without infection or treatment as a control. The adopted antibiotic regimen included clarithromycin 61 mg/kg b.w., moxifloxacin 25 mg/kg b.w. and ethambutol 60 mg/kg b.w. administered by crop gavage every 12 h for 18 weeks. Despite a significant improvement in the condition of the infected, treated birds, the four-month therapy was not sufficient for the complete recovery of all.
authors.affiliation: a Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine , Warsaw University of Life Sciences , 159c Nowoursynowska St., 02-776 Warsaw , Poland.
authors.forename: A
authors.initials: A
authors.lastname: Ledwoń
authors.affiliation: a Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine , Warsaw University of Life Sciences , 159c Nowoursynowska St., 02-776 Warsaw , Poland.
authors.forename: I
authors.initials: I
authors.lastname: Dolka
authors.affiliation: a Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine , Warsaw University of Life Sciences , 159c Nowoursynowska St., 02-776 Warsaw , Poland.
authors.forename: B
authors.initials: B
authors.lastname: Dolka
authors.affiliation: a Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine , Warsaw University of Life Sciences , 159c Nowoursynowska St., 02-776 Warsaw , Poland.
authors.forename: M
authors.initials: M
authors.lastname: Cegiełkowska
authors.affiliation: b Laboratory of Veterinary Epidemiology and Economics Faculty of Veterinary Medicine , Warsaw University of Life Sciences , 159c Nowoursynowska St., 02-776 Warsaw , Poland.
authors.forename: M
authors.initials: M
authors.lastname: Czopowicz
authors.affiliation: a Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine , Warsaw University of Life Sciences , 159c Nowoursynowska St., 02-776 Warsaw , Poland.
authors.forename: P
authors.initials: P
authors.lastname: Szeleszczuk
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use; D046094:Galliformes / Q000382:microbiology*; D008297:Male; D046408:Melopsittacus / Q000382:microbiology*; D000077266:Moxifloxacin; D009162:Mycobacterium avium / Q000187:drug effects*; D014379:Tuberculosis, Avian / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D004977:Ethambutol; D017291:Clarithromycin; D000077266:Moxifloxacin