title: Cutaneous manifestations and gastrointestinal disorders: Report of two emblematic cases.
abstract: Gastrointestinal (GI) diseases, such as inflammatory bowel diseases (IBD), can manifest themselves with intestinal and extra-intestinal symptoms. Among the latter, cutaneous manifestations, such as pyoderma gangraenosum (PG) and metastatic Crohn's disease (MCD), represent a possible onset of IBD, with or without simultaneous bowel alterations. In such cases, intestinal and skin lesions are supported by the same immune-mediated mechanism. We hereby report two cases of patients with skin manifestations together with signs and symptoms suggestive of IBD. IBD and some skin lesions arise from the same immune-mediated mechanism. A multidisciplinary approach to these immune-mediated diseases is needed for an early and correct diagnosis, which in turn may lead to the use of the right drug avoiding useless treatment.
authors.affiliation: NESMOS, U.O.C. Dermatology, School of Medicine and Psychology, University Sapienza, Sant'Andrea Hospital, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Carlesimo
authors.affiliation: NESMOS, U.O.C. Dermatology, School of Medicine and Psychology, University Sapienza, Sant'Andrea Hospital, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Abruzzese
authors.affiliation: NESMOS, U.O.C. Dermatology, School of Medicine and Psychology, University Sapienza, Sant'Andrea Hospital, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Narcisi
authors.affiliation: NESMOS, Department of Digestive Endoscopy, School of Medicine and Psychology, University Sapienza, Sant'Andrea Hospital, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Margagnoni
authors.affiliation: NESMOS, Department of Digestive Endoscopy, School of Medicine and Psychology, University Sapienza, Sant'Andrea Hospital, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Zerboni
authors.affiliation: NESMOS, Department of Digestive Endoscopy, School of Medicine and Psychology, University Sapienza, Sant'Andrea Hospital, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Purchiaroni
authors.affiliation: NESMOS, Department of Digestive Endoscopy, School of Medicine and Psychology, University Sapienza, Sant'Andrea Hospital, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pagnini
authors.affiliation: NESMOS, Department of Digestive Endoscopy, School of Medicine and Psychology, University Sapienza, Sant'Andrea Hospital, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Di Giulio
authors.affiliation: NESMOS, Department of Digestive Endoscopy, School of Medicine and Psychology, University Sapienza, Sant'Andrea Hospital, Rome, Italy.
authors.forename: V D
authors.initials: VD
authors.lastname: Corleto
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000209:etiology; D012871:Skin Diseases / Q000209:etiology*
keywords: Cutaneous manifestations; Immune-mediated mechanism; Inflammatory bowel disease