title: Thalamic atrophy predicts cognitive impairment in relapsing remitting multiple sclerosis. Effect on instrumental activities of daily living and employment status.
abstract: BACKGROUND
  Cognitive impairment is an important predictor of quality of life at all stages of MS. Magnetic Resonance Imaging (MRI) markers have been used to associate tissue damage with cognitive dysfunction.
  
  
  OBJECTIVE
  The aim of the study was to designate the MRI marker that predicts cognitive decline and explore its effect on every day activities and employment status.
  
  
  METHODS
  50 RRMS patients and 31 healthy participants underwent neuropsychological assessment using the Trail Making Test (TMT) parts A and B, semantic and phonological verbal fluency task and a computerized cognitive screening battery (Central Nervous System Vital Signs). Everyday activities were evaluated with the instrumental activities of daily living (IADL) scale and employment status. Brain MRI was performed in all participants. We measured total lesion volume, third ventricle width, corpus callosum and thalamic atrophy.
  
  
  RESULTS
  The frequency of cognitive dysfunction for our RRMS patients was 38%. RRMS patients differed significantly from controls on the TMTA, TMTB, phonological verbal fluency task, memory, psychomotor speed, reaction time and cognitive flexibility. Neuropsychological measures had a strong correlation with all MRI atrophy measures and a weak or moderate correlation with lesion volume. Psychomotor speed was the most sensitive marker for IADL, while memory and TMTB for employment status. Thalamic area was the most sensitive MRI marker for memory, psychomotor speed and TMTB..
  
  
  CONCLUSIONS
  Thalamic atrophy predicts the clinically meaningful cognitive decline in our RRMS patients.
authors.affiliation: Department of Neurology,University of Nottingham,Queen's Medical Centre,Derby Road,NottinghamNG7 2UH,UK; Neuropsychology Section,Department of Neurology,University of Patras Medical School,Patras265 04,Greece. Electronic address: tpapathanasiou@gmail.com.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Papathanasiou
authors.affiliation: Neuropsychology Section,Department of Neurology,University of Patras Medical School,Patras265 04,Greece.
authors.forename: Lambros
authors.initials: L
authors.lastname: Messinis
authors.affiliation: Department of Radiology,University of Patras Medical School,Patras265 04,Greece.
authors.forename: Petros
authors.initials: P
authors.lastname: Zampakis
authors.affiliation: Department of Medical Physics,University of Patras Medical School,Patras265 04,Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Panagiotakis
authors.affiliation: Department of Psychiatry,University of Patras Medical School,Patras265 04,Greece.
authors.forename: Philippos
authors.initials: P
authors.lastname: Gourzis
authors.affiliation: Hellenic Open University,Patras265 04,Greece.
authors.forename: Vasileios
authors.initials: V
authors.lastname: Georgiou
authors.affiliation: Neuropsychology Section,Department of Neurology,University of Patras Medical School,Patras265 04,Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Papathanasopoulos
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000328:Adult; D001284:Atrophy / Q000150:complications / Q000473:pathology / Q000523:psychology; D001288:Attention / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000150:complications / Q000473:pathology* / Q000523:psychology; D004651:Employment; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D011788:Quality of Life / Q000523:psychology; D011930:Reaction Time / Q000502:physiology; D013788:Thalamus / Q000473:pathology*
keywords: Cognitive impairment; Employment status; Instrumental activities of daily living; MRI; Multiple sclerosis; Thalamus