title: Major depressive disorder, personality disorders, and coping strategies are independent risk factors for lower quality of life in non-metastatic breast cancer patients.
abstract: OBJECTIVE
  Our aim was to identify risk factors for lower quality of life (QOL) in non-metastatic breast cancer patients.
  
  
  METHODS
  Our study included 120 patients from the University Hospital Centers of Tours and Poitiers. This cross-sectional study was conducted 7 months after patients' breast cancer diagnosis and assessed QOL (Quality of Life Questionnaire Core 30 = QLQ-C30), socio-demographic characteristics, coping strategies (Brief-COPE), physiological and biological variables (e.g., initial tumor severity and types of treatment received), the existence of major depressive disorder (Mini International Neuropsychiatric Interview), and pain severity (Questionnaire de Douleur Saint Antoine). We assessed personality disorders 3 months after diagnosis (Vragenlijst voor Kenmerken van de Persoonlijkheid questionnaire). We used multiple linear regression models to determine which factors were associated with physical, emotional, and global QOL.
  
  
  RESULTS
  Lower physical QOL was associated with major depressive disorder, younger age, a more severe initial tumor stage, and the use of the behavioral disengagement coping. Lower emotional QOL was associated with major depressive disorder, the existence of a personality disorder, a more severe pain level, higher use of self-blame, and lower use of acceptance coping strategies. Lower global QOL was associated with major depressive disorder, the existence of a personality disorder, a more severe pain level, higher use of self-blame, lower use of positive reframing coping strategies, and an absence of hormone therapy.
  
  
  CONCLUSIONS
  Lower QOL scores were more strongly associated with variables related to the individual's premorbid psychological characteristics and the manner in which this individual copes with the cancer (e.g., depression, personality, and coping) than to cancer-related variables (e.g., treatment types and cancer severity). Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Clinique Psychiatrique Universitaire, CHRU de Tours, Tours, France.|Équipe de Liaison et de Soins en Addictologie, CHRU de Tours, Tours, France.|Département de Psychologie, EA 2114 Psychologie des Âges de la Vie, Université François Rabelais de Tours, Tours, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Brunault
authors.affiliation: Clinique Psychiatrique Universitaire, CHRU de Tours, Tours, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Champagne
authors.affiliation: Clinique Psychiatrique Universitaire, CHRU de Tours, Tours, France.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Huguet
authors.affiliation: Clinique Psychiatrique Universitaire, CHRU de Tours, Tours, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Suzanne
authors.affiliation: Centre Hospitalier Henri-Laborit, Service de Psychiatrie, Poitiers, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Senon
authors.affiliation: Service de Gynécologie Obstétrique, CHRU de Tours, Tours, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Body
authors.affiliation: Service d'Information Médicale, Épidémiologie et Économie de la Santé, CHRU de Tours, Tours, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Rusch
authors.affiliation: Service de Gynécologie Obstétrique, CHU de Poitiers, Poitiers, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Magnin
authors.affiliation: Centre Hospitalier Henri-Laborit, Service de Psychiatrie, Poitiers, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Voyer
authors.affiliation: Département de Psychologie, EA 2114 Psychologie des Âges de la Vie, Université François Rabelais de Tours, Tours, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Réveillère
authors.affiliation: Clinique Psychiatrique Universitaire, CHRU de Tours, Tours, France.|UMR INSERM U930 'Imagerie et Cerveau', Tours, France.|Université François Rabelais de Tours, Tours, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Camus
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000523:psychology*; D003430:Cross-Sectional Studies; D003863:Depression / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis*; D004644:Emotions; D005260:Female; D006801:Humans; D008875:Middle Aged; D010146:Pain; D010551:Personality; D010554:Personality Disorders / Q000175:diagnosis*; D011788:Quality of Life / Q000523:psychology*; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires