title: Subacute static magnetic field exposure in rat induces a pseudoanemia status with increase in MCT4 and Glut4 proteins in glycolytic muscle.
abstract: The purpose of this study was to investigate the effect of subacute exposure to static magnetic fields (SMF) on hematological and muscle biochemical parameters in rats. Male Wistar rats, daily exposed to SMF, were exposed to SMF (128 mT, 1 h/day) during 15 consecutive days. SMF-exposed rats showed a significant decrease in red blood cell (RBC) count, hemoglobin (Hb), and hematocrit (Ht) values compared to sham-exposed rats (p < 0.05). Concomitant decreases of plasma iron level against increase in transferrin amount were also observed after SMF exposure (p < 0.0.05). In postprandial condition, SMF-exposed rats presented higher plasma lactate (p < 0.01). Additionally, SMF exposure increased monocarboxylate transporters (MCT4) and glucose transporter 4 (Glut4)'s contents only in glycolytic muscle (p < 0.05). SMF exposure induced alteration of hematological parameters; importantly, we noticed a pseudoanemia status, which seems to affect tissue oxygen delivery. Additionally, SMF exposure seems to favor the extrusion of lactate from the cell to the blood compartment. Given that, these arguments advocate for an adaptive response to a hypoxia status following SMF exposure.
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, 7021, Tunisia. Miryam.Elferchichi@fsb.rnu.tn.|PHYMEDEXP, INSERM U1046, CNRS UMR 9214, Université de Montpellier, Montpellier, France. Miryam.Elferchichi@fsb.rnu.tn.
authors.forename: Miryam
authors.initials: M
authors.lastname: Elferchichi
authors.affiliation: PHYMEDEXP, INSERM U1046, CNRS UMR 9214, Université de Montpellier, Montpellier, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Mercier
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, 7021, Tunisia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ammari
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, 7021, Tunisia.
authors.forename: Hatem
authors.initials: H
authors.lastname: Belguith
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, 7021, Tunisia.
authors.forename: Hafedh
authors.initials: H
authors.lastname: Abdelmelek
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, 7021, Tunisia.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Sakly
authors.affiliation: PHYMEDEXP, INSERM U1046, CNRS UMR 9214, Université de Montpellier, Montpellier, France.
authors.forename: Karen
authors.initials: K
authors.lastname: Lambert
mesh_terms: D000740:Anemia / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D051275:Glucose Transporter Type 4 / Q000235:genetics / Q000378:metabolism*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D060526:Magnetic Fields / Q000009:adverse effects*; D008297:Male; D027501:Monocarboxylic Acid Transporters / Q000235:genetics / Q000378:metabolism*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D051275:Glucose Transporter Type 4; D006454:Hemoglobins; D027501:Monocarboxylic Acid Transporters; D009124:Muscle Proteins; C516342:Slc16a3 protein, rat; C495694:Slc2a4 protein, rat
keywords: Glut4; Hematological parameters; MCT transporters; Rat; Static magnetic field