title: Ménétrier's disease: Long-term remission with lanreotide.
abstract: Ménétrier's disease is a rare hypertrophic gastropathy, causing protein leak. An overexpression of transforming growth factor alpha is involved. In inhibiting the epidermal growth factor receptor, cetuximab and somatostatin analogues are the two most promising treatments, allowing to avoid radical gastrectomy. We report the case of a patient with a sustained clinical remission after treatment with lanreotide, but without complete endoscopic healing. We discuss the available therapeutic options and present a literature review of somatostatin analogues for the treatment of Ménétrier's disease.
authors.affiliation: Service d'Hépato-Gastro-entérologie, Hôpital Robert-Debré, 51100 Reims, France. Electronic address: aheurgue@chu-reims.fr.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Heurgué-Berlot
authors.affiliation: CRIC U73, Hôpital Robert-Debré, 51100 Reims, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Féron
authors.affiliation: Laboratoire d'Anatomie et de Cytologie pathologiques, Centre Hospitalier de La Rochelle, 17000 La Rochelle, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Jazeron
authors.affiliation: Service de Radiologie, Hôpital Robert-Debré, 51100 Reims, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Hoeffel
authors.affiliation: Laboratoire d'Anatomie et de Cytologie pathologiques, Hôpital Robert-Debré, 51100 Reims, France.
authors.forename: Marie-Danièle
authors.initials: MD
authors.lastname: Diebold
authors.affiliation: Service d'Hépato-Gastro-entérologie, Hôpital Robert-Debré, 51100 Reims, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Cadiot
mesh_terms: D005758:Gastritis, Hypertrophic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D012074:Remission Induction; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin