title: Urinary excretion of brush-border enzymes of the proximal renal tubules in pregnant women with hypertensive disorders.
abstract: OBJECTIVE
  The aim of our study was to evaluate urinary excretion of three brush border enzymes: gamma-glutamyl transferase, alanine aminopeptidase, and leucyl aminopeptidase in pregnant women with various types of hypertensive disorders.
  
  
  METHODS
  The study included 120 pregnant women, further subdivided into four groups: 41 women at ≥ 20 weeks gestation with gestational hypertension, 28 women > 20 weeks of pregnancy with preeclampsia, 21 women with chronic hypertension identified > 20 weeks of pregnancy and 30 healthy pregnant controls.
  
  
  RESULTS
  No significant differences in urinary levels of all three of the brush border enzymes were found between the groups. Also, there was no correlation between enzyme concentration in the urine and blood pressure values in any of the analyzed groups of pregnant women.
  
  
  CONCLUSIONS
  The obtained results suggest no damage to the brush border of the proximal kidney tubules in the early stages of disorders associated with increased blood pressure during pregnancy.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Torb
authors.forename: Ewelina
authors.initials: E
authors.lastname: Chłapowska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Szymańska-Pasternak
authors.forename: Joanna
authors.initials: J
authors.lastname: Bober
authors.forename: Ewa
authors.initials: E
authors.lastname: Kwiatkowska
authors.forename: Wioletta
authors.initials: W
authors.lastname: Konstanty-Kurkiewicz
mesh_terms: D018826:CD13 Antigens / Q000652:urine*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000201:enzymology* / Q000652:urine; D007687:Kidney Tubules, Proximal; D007931:Leucyl Aminopeptidase / Q000652:urine*; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods; D012016:Reference Values; D005723:gamma-Glutamyltransferase / Q000652:urine*
chemical_list: D005723:gamma-Glutamyltransferase; D007931:Leucyl Aminopeptidase; D018826:CD13 Antigens