title: Physiological Mechanisms of Weight Gain-Induced Steatosis in People With Obesity.
abstract: Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.
authors.affiliation: Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri.
authors.forename: Elisa
authors.initials: E
authors.lastname: Fabbrini
authors.affiliation: Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri.
authors.forename: Courtney
authors.initials: C
authors.lastname: Tiemann Luecking
authors.affiliation: Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri.
authors.forename: Latisha
authors.initials: L
authors.lastname: Love-Gregory
authors.affiliation: Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri.
authors.forename: Adewole L
authors.initials: AL
authors.lastname: Okunade
authors.affiliation: Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Yoshino
authors.affiliation: Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri.
authors.forename: Gemma
authors.initials: G
authors.lastname: Fraterrigo
authors.affiliation: Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri.
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Patterson
authors.affiliation: Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri. Electronic address: sklein@dom.wustl.edu.
authors.forename: Samuel
authors.initials: S
authors.lastname: Klein
mesh_terms: D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D011877:Radionuclide Imaging; D012016:Reference Values; D018570:Risk Assessment; D015430:Weight Gain / Q000502:physiology*
chemical_list: D005227:Fatty Acids; D008079:Lipoproteins, VLDL
keywords: Fatty Acid Oxidation; Overweight; VLDL; apoB100