title: Radiotherapy in the Era of Precision Medicine.
abstract: Current predictors of radiation response are largely limited to clinical and histopathologic parameters, and extensive systematic analyses of the correlation between radiation sensitivity and genomic parameters remain lacking. In the era of precision medicine, the lack of -omic determinants of radiation response has hindered the personalization of radiation delivery to the unique characteristics of each patient׳s cancer and impeded the discovery of new therapies that can be administered concurrently with radiation therapy. The cataloging of the -omic determinants of radiation sensitivity of cancer has great potential in enhancing efficacy and limiting toxicity in the context of a new approach to precision radiotherapy. Herein, we review concepts and data that contribute to the delineation of the radiogenomic landscape of cancer.
authors.affiliation: Department of Translational Hematology Oncology Research, Cleveland Clinic, Cleveland, OH.
authors.forename: Brian
authors.initials: B
authors.lastname: Yard
authors.affiliation: Department of Translational Hematology Oncology Research, Cleveland Clinic, Cleveland, OH.
authors.forename: Eui Kyu
authors.initials: EK
authors.lastname: Chie
authors.affiliation: Case Western Reserve University, Department of Genetics, Cleveland, OH.
authors.forename: Drew J
authors.initials: DJ
authors.lastname: Adams
authors.affiliation: Department of Translational Hematology Oncology Research, Cleveland Clinic, Cleveland, OH.
authors.forename: Craig
authors.initials: C
authors.lastname: Peacock
authors.affiliation: Department of Translational Hematology Oncology Research, Cleveland Clinic, Cleveland, OH; Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH. Electronic address: abazeem@ccf.org.
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Abazeed
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D057285:Precision Medicine