title: Hysteroscopic treatment of uterine tumor resembling ovarian sex cord-like tumor (UTROSCT).
abstract: The decision to preserve the uterus in a young nulliparous woman with an extremely rare tumor is challenging. Uterine tumor resembling ovarian sex cord-like tumor (UTROSCT) belongs to the rarest uterine pathologies. A 22-year-old nulligravida with uterine bleeding underwent a hysteroscopic resection of an intrauterine mass presumed as grade-1 submucous myoma. According to the presence of sex cord-like differentiation and positivity for calretinin, CD99, estrogen receptor, vimentin, WT1 and Melan-A, the tumor was diagnosed as UTROSCT. After 28 months, without any adjuvant therapy, the patient is still free of recurrence. This is the youngest patient with UTROSCT reported so far, with the longest follow-up among all five cases treated via hysteroscopy. Although UTROSCT has been traditionally treated with hysterectomy (with or without bilateral salpingo-oophorectomy), no established treatment protocol for UTROSCT exists. UTROSCT shows a low-malignant potential, but metastasizing and recurrent cases occur. In light of the probably less aggressive tumor biology and with respect to the patient's autonomy, a conservative, uterus preserving treatment appears to be justified in selected cases in which close follow-up can be guaranteed. Further case reports are needed to prove the safety of organ-preserving strategy in UTROSCT.
authors.affiliation: a Department of Gynecology and Obstetrics, St. Josefskrankenhaus , Teaching Hospital of the University of Freiburg , Freiburg , Germany .
authors.forename: Rafal
authors.initials: R
authors.lastname: Watrowski
authors.affiliation: a Department of Gynecology and Obstetrics, St. Josefskrankenhaus , Teaching Hospital of the University of Freiburg , Freiburg , Germany .
authors.forename: Christoph
authors.initials: C
authors.lastname: Jäger
authors.affiliation: b Laboratory for Cytodiagnostics , Freiburg , Germany .
authors.forename: Jochen
authors.initials: J
authors.lastname: Möckel
authors.affiliation: c Department of Pathology , University Hospital Freiburg , Freiburg , Germany , and.
authors.forename: Philipp
authors.initials: P
authors.lastname: Kurz
authors.affiliation: d Institute of Pathology, Center for Gynecopathology , Mannheim , Germany.
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schmidt
authors.affiliation: b Laboratory for Cytodiagnostics , Freiburg , Germany .|c Department of Pathology , University Hospital Freiburg , Freiburg , Germany , and.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Freudenberg
mesh_terms: D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D015907:Hysteroscopy; D059351:Organ Sparing Treatments / Q000379:methods*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000601:surgery*; D014594:Uterine Neoplasms / Q000601:surgery*; D014599:Uterus / Q000601:surgery*; D055815:Young Adult
keywords: Hysteroscopy; UTROSCT; low malignant potential; uterine tumors; uterus preserving