title: Final diagnosis of children and adolescents with musculoskeletal complaints.
abstract: BACKGROUND
  Musculoskeletal complaints (MSCs) are one of the leading causes of outpatient admissions. However, analytical and epidemiological data are limited. The aim of this study is to identify the etiology of MSCs (excluding acute traumatic conditions) in children and adolescents, and to identify clues for the differential diagnosis.
  
  
  METHODS
  Children and adolescents presenting with musculoskeletal pain, swelling or limitation of movement were enrolled in a prospective design. Demographic, clinical and laboratory features were recorded.
  
  
  RESULTS
  Four hundred and twenty-two children (48.2% female) with a mean age of 7.90±3.95 years were enrolled. Etiology was identified in 97.2% of the cases: non-inflammatory and mechanical conditions (NIMC; 42.2%), rheumatic diseases (RD; 31%), infection-related disorders (IRD; 21.6%) and malignancy (M; 2.4%). NIMC was characterized by longer duration of complaints, a higher rate of non-articular complaints, a lower rate of joint involvement and limping and lower levels of leukocytes, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). The prevalence of RD was higher in the age group of >12 years; younger age was associated with higher prevalence of IRD. Small-joint involvement was highest in the RD group. Median ESR in RD and M groups was higher; compared to the other groups; the frequency of patients with ESR ≥ 60 mm/hr was higher in the M group; compared to the RD group. In the RD group familial Mediterranean fever (9.7%), juvenile idiopathic arthritis (8.3%) and Henoch-Schönlein purpura (5.7%) were the leading causes of MSCs.
  
  
  CONCLUSIONS
  RD accounted for one-third of the etiologies for MSCs. Age, duration of complaints, pattern of joint involvement and acute phase reactants are practical tools that may guide the pediatrician for diagnosis.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Cavkaytar
authors.affiliation: Division of Pediatric Nephrology and Rheumatology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey - aduzova@hacettepe.edu.tr.
authors.forename: Ali
authors.initials: A
authors.lastname: Düzova
authors.affiliation: Division of Pediatric Emergency Medicine, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Tekşam
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Karabulut
authors.affiliation: Division of Adolescent Medicine, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Derman
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Gulsev
authors.initials: G
authors.lastname: Kale
authors.affiliation: Division of Pediatric Nephrology and Rheumatology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Seza
authors.initials: S
authors.lastname: Ozen
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009140:Musculoskeletal Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D015995:Prevalence; D011446:Prospective Studies; D012216:Rheumatic Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology