title: Implementation and evaluation of an isoniazid preventive therapy pilot program among HIV-infected patients in Vietnam, 2008-2010.
abstract: BACKGROUND
  WHO recommends screening for TB and evaluation for isoniazid preventive therapy (IPT) based on evidence that they reduce TB-related morbidity and mortality among HIV-infected persons. In Vietnam, an IPT pilot was implemented in two provinces; TB screening, treatment and outcomes were evaluated to inform the adoption and scale-up of IPT.
  
  
  METHODS
  During April 2008 to March 2010, eligible HIV-infected persons aged >15 years, with no previous or current TB treatment, alcohol abuse or liver disease were screened for TB. If TB disease was ruled out based on symptoms, chest x-rays and sputum smears, isoniazid was administered for 9 months.
  
  
  RESULTS
  Among 1281 HIV-infected persons who received initial eligibility screening, 520 were referred to and evaluated at district TB clinics for TB disease or IPT eligibility. Active TB was diagnosed in 17 patients and all were started on treatment. Of 520 patients evaluated, 416 (80.0%) initiated IPT: 382 (91.8%) completed IPT, 17 (4.1%) stopped treatment, 8 (1.9%) died, 3 (0.7%) developed TB during IPT and 6 (1.4%) had unknown outcomes. No severe adverse events were reported.
  
  
  CONCLUSIONS
  IPT treatment completion was high; no serious complications occurred. Improving and expanding intensified case-finding and IPT should be considered in Vietnam.
authors.affiliation: U.S. Centers for Disease Control and Prevention, US Embassy, 7 Lang Ha street, Hanoi, Vietnam Trinhttt@state.gov.
authors.forename: Thuy T
authors.initials: TT
authors.lastname: Trinh
authors.affiliation: Vietnam National TB Program, 463 Hoang Hoa Tham, Hanoi, Vietnam.
authors.forename: Dien T
authors.initials: DT
authors.lastname: Han
authors.affiliation: U.S. Centers for Disease Control and Prevention, 1600 Clifton Rd MS E-10 Atlanta, GA 30333, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Bloss
authors.affiliation: U.S. Centers for Disease Control and Prevention, US Embassy, 7 Lang Ha street, Hanoi, Vietnam.
authors.forename: Thai H
authors.initials: TH
authors.lastname: Le
authors.affiliation: Vietnam Administration of HIV/AIDS Control (VAAC) and Leadership and Investment in Fighting an Epidemic - Global AIDS Program (LIFE-GAP), 7th floor, HEID building, K3b, 6A lane, Thanh Cong Street, Hanoi, Vietnam.
authors.forename: Tung T
authors.initials: TT
authors.lastname: Vu
authors.affiliation: An Giang Provincial TB and HIV/AIDS Control Center, 12B Le Loi, Long Xuyen, An Giang, Vietnam.
authors.forename: Anh H
authors.initials: AH
authors.lastname: Mai
authors.affiliation: Vietnam National TB Program, 463 Hoang Hoa Tham, Hanoi, Vietnam.
authors.forename: Nhung V
authors.initials: NV
authors.lastname: Nguyen
authors.affiliation: Vietnam Administration of HIV/AIDS Control (VAAC) and Leadership and Investment in Fighting an Epidemic - Global AIDS Program (LIFE-GAP), 7th floor, HEID building, K3b, 6A lane, Thanh Cong Street, Hanoi, Vietnam.
authors.forename: Long T
authors.initials: LT
authors.lastname: Nguyen
authors.affiliation: Vietnam National TB Program, 463 Hoang Hoa Tham, Hanoi, Vietnam.
authors.forename: Sy N
authors.initials: SN
authors.lastname: Dinh
authors.affiliation: CDC Southeast Asia Regional Office, DDC 7, Thailand Ministry of Public Health, Soi 4, Nonthaburi, 11000, Thailand.
authors.forename: Sara
authors.initials: S
authors.lastname: Whitehead
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000517:prevention & control*; D000328:Adult; D000465:Algorithms; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D010865:Pilot Projects; D016730:Program Development; D015397:Program Evaluation; D016896:Treatment Outcome; D014376:Tuberculosis / Q000453:epidemiology / Q000517:prevention & control*; D014744:Vietnam / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid
keywords: HIV/AIDS; Isoniazid; Preventive therapy; TB; Vietnam