title: [Characteristics of the regulation of neurotrophic mechanisms in ischemic stroke].
abstract: OBJECTIVE
  To explore the endogenous and pharmacological activation of neurotrophic mechanisms in a model of brain ischemic lesion in rats.
  
  
  METHODS
  The study was performed on 170 male albino rats (195-205 g). The model of ischemic stroke was accomplished by the electrocoagulation of the proximal segment of the left middle cerebral artery and simultaneous permanent ligation of the left common carotid artery.
  
  
  CONCLUSIONS
  The evaluation of NSE, NO, VEGF, NGF levels in the brain cytoplasmic lysate and plasma showed the delayed activation of neurotrophic mechanisms in astrocytes accompanied by a decrease in delayed alteration of neurons. The use of cytoflavin in the treatment of stroke was accompanied by the earlier and more intense activation of neurotrophic mechanisms in astrocytes, delayed activation of neurotrophic mechanisms in endothelial cells, which promoted neuroprotection in acute ischemic stroke.
authors.affiliation: Kirov Military Medical Academy, St. Petersburg.
authors.forename: N V
authors.initials: NV
authors.lastname: Tsygan
authors.affiliation: St. Petersburg State Pediatric Medical University, St. Petersburg.
authors.forename: A P
authors.initials: AP
authors.lastname: Trashkov
authors.affiliation: St. Petersburg State Pediatric Medical University, St. Petersburg.
authors.forename: V A
authors.initials: VA
authors.lastname: Yakovleva
authors.affiliation: St. Petersburg State Pediatric Medical University, St. Petersburg.
authors.forename: V M
authors.initials: VM
authors.lastname: Malkova
authors.affiliation: St. Petersburg State Pediatric Medical University, St. Petersburg.
authors.forename: E V
authors.initials: EV
authors.lastname: Gracheva
authors.affiliation: Institute of Toxicology of the Federal Medical-Biological Agency, St. Petersburg.
authors.forename: A L
authors.initials: AL
authors.lastname: Kovalenko
authors.affiliation: St. Petersburg State Pediatric Medical University, St. Petersburg.
authors.forename: A G
authors.initials: AG
authors.lastname: Vasiliev
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000494:pharmacology / Q000627:therapeutic use*; D007290:Inosine Diphosphate / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009414:Nerve Growth Factors / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D009536:Niacinamide / Q000494:pharmacology / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D051381:Rats; D020521:Stroke / Q000188:drug therapy* / Q000378:metabolism*; D013386:Succinates / Q000494:pharmacology / Q000627:therapeutic use*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000097:blood / Q000378:metabolism*
chemical_list: D004338:Drug Combinations; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D013386:Succinates; D042461:Vascular Endothelial Growth Factor A; C507879:cytoflavin; D009536:Niacinamide; D009569:Nitric Oxide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D010751:Phosphopyruvate Hydratase