title: Effects of fibroblast transplantation into the internal pallidum on levodopa-induced dyskinesias in parkinsonian non-human primates.
abstract: Recent studies have shown that fibroblast transplantation can modify the activity of basal ganglia networks in models of Parkinson's disease. To determine its effects on parkinsonian motor symptoms, we performed autologous dermal fibroblast transplantation into the internal pallidum (GPi) in two parkinsonian rhesus monkeys with stable levodopa-induced dyskinesias (LIDs). Levodopa responses were assessed every week after transplantation for three months. A reduction of between 58% and 64% in total LIDs on the contralateral side was observed in both animals. No clear LID changes were observed on the ipsilateral side. These effects lasted the entire 3-month period in one monkey, but declined after 6-8 weeks in the other. The antiparkinsonian effects of levodopa did not diminish. The results of this pilot study indicate that fibroblast transplantation into the GPi may have beneficial effects on LIDs and warrant further investigation for potential therapeutic use.
authors.affiliation: Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Atlanta, GA, USA.
authors.forename: Arun
authors.initials: A
authors.lastname: Singh
authors.affiliation: Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Claire A
authors.initials: CA
authors.lastname: Gutekunst
authors.affiliation: Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Atlanta, GA, USA.
authors.forename: Subramaniam
authors.initials: S
authors.lastname: Uthayathas
authors.affiliation: Molecular Pharmacology Department, Rappaport Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: John P M
authors.initials: JP
authors.lastname: Finberg
authors.affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Klaus
authors.initials: K
authors.lastname: Mewes
authors.affiliation: Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Gross
authors.affiliation: Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Atlanta, GA, USA.|Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Stella M
authors.initials: SM
authors.lastname: Papa
authors.affiliation: GeneGrafts Ltd, Haifa, Israel. yairfeld@gmail.com.
authors.forename: Yair
authors.initials: Y
authors.lastname: Feld
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000009:adverse effects; D004409:Dyskinesia, Drug-Induced / Q000601:surgery*; D005347:Fibroblasts / Q000637:transplantation*; D005917:Globus Pallidus / Q000601:surgery; D007980:Levodopa / Q000009:adverse effects; D008253:Macaca mulatta; D020734:Parkinsonian Disorders / Q000601:surgery*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa
keywords: antiparkinsonian; autologous; globus pallidum; levodopa; monkeys