title: [Pregabalin Dependence: A Case Report].
abstract: Pregabalin is a new generation antiepileptic that exerts its effect by decreasing the release of such neurotransmitters as glutamate, noradrenaline, and substance P. Pregabalin can be prescribed in Turkey at 150-600 mg to treat neuropathic pain, generalized anxiety disorder, and fibromyalgia, and as concomitant therapy in adult patients with partial epilepsy. Experimental studies have shown that pregabalin could be beneficial in the treatment of benzodiazepine dependence and withdrawal, as well as for relapse prevention in patients with alcohol dependence. Nonetheless, the number of case reports on the abuse potential of pregabalin has increased. Herein we present a patient with pregabalin dependence. The patients underlying alcohol and polysubstance dependence, and symptoms of generalized anxiety were thought to contribute to the development of pregabalin dependence. The patient reported that he had experienced severe withdrawal symptoms when he tried to stop using pregabalin. Bupropion and low-dose quetiapine were added to his paroxetine treatment, and pregabalin was discontinued gradually. Following this treatment the patient had not exhibited any signs of pregabalin dependence for one month. Although pregabalin is a promising drug for various psychiatric disorders, it should be used carefully in patients with a history of substance dependence.
authors.forename: Ebru
authors.initials: E
authors.lastname: Aldemir
authors.forename: Ayşe Ender
authors.initials: AE
authors.lastname: Altıntoprak
authors.forename: Hakan
authors.initials: H
authors.lastname: Coşkunol
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D000069583:Pregabalin / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000209:etiology
chemical_list: D000927:Anticonvulsants; D000069583:Pregabalin