title: Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives.
abstract: An efficient and practical one-pot domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives from readily available 2-(2-bromophenyl)acetonitriles was developed. The overall protocol involves a Buchwald-Hartwig type coupling and a base-promoted intramolecular nucleophilic reaction. The reaction scope, advantages and limitations are discussed.
authors.affiliation: Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, P. R. China. lf_deng@126.com.
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.forename: Haoyue
authors.initials: H
authors.lastname: Xiang
authors.forename: Fangxia
authors.initials: F
authors.lastname: Zhu
authors.forename: Xing
authors.initials: X
authors.lastname: Xu
authors.forename: Lianfu
authors.initials: L
authors.lastname: Deng
authors.forename: Chunhao
authors.initials: C
authors.lastname: Yang
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C000606450:1-phenyl-1H-indol-2-amine; C000606451:5-amino-indolo(1,2-a)quinazoline; D007211:Indoles; D009942:Organometallic Compounds; D011799:Quinazolines; D010165:Palladium