title: mTORC1 maintains metabolic balance.
abstract: Anticancer therapeutics aimed at the inhibition of mTORC1 activity shift metabolism to favor the degradation of extracellular proteins. Recently Thompson and colleagues demonstrated a novel regulatory mechanism whereby mTORC1 plays a distinct role as a key regulator of metabolism depending on the environmental nutrient status.
authors.affiliation: Comparative Biomedicine Research Branch, Division of Cancer Biology, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi-do 410-769, Republic of Korea.
authors.forename: Heesun
authors.initials: H
authors.lastname: Cheong
authors.affiliation: University of Michigan, Life Sciences Institute, Ann Arbor, MI 481098-2216, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Klionsky
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000166:cytology*; D046912:Multiprotein Complexes / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D011506:Proteins; D058570:TOR Serine-Threonine Kinases