title: CRIB scores as a tool for assessing risk for the development of pulmonary hypertension in extremely preterm infants with bronchopulmonary dysplasia.
abstract: OBJECTIVE
  Bronchopulmonary dysplasia (BPD) increases the risk for developing pulmonary hypertension (PH). However, the risk factors associated with BPD-associated PH remain unclear. Our primary aim was to determine perinatal risk factors associated with the development of PH in infants with BPD.
  
  
  METHODS
  We retrospectively reviewed medical records of 303 infants born at ≤ 28 weeks' gestation. Infants were categorized as having no, mild, moderate, or severe BPD. PH was diagnosed by echocardiogram. Data were analyzed using Fisher exact test, two-sample t-test, and multivariable logistic regression.
  
  
  RESULTS
  The incidence of PH in our cohort was 12%. Infants with PH had lower birth weights and gestational ages (p < 0.001). After controlling for confounding variables, severe BPD (p < 0.001), and higher Clinical Risk Index for Babies (CRIB) scores (p = 0.04) were associated with the development of PH.
  
  
  CONCLUSIONS
  Severe BPD increases the risk for developing PH. Higher CRIB scores correlate with PH development in infants with BPD. We speculate that CRIB scores may allow for early categorization of preterm infants with a higher likelihood of developing PH.
authors.affiliation: Division of Neonatology, Department of Pediatrics, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Christie J
authors.initials: CJ
authors.lastname: Bruno
authors.affiliation: Department of Pediatrics, The Children's Hospital at Montefiore, Bronx, New York.
authors.forename: Meera
authors.initials: M
authors.lastname: Meerkov
authors.affiliation: Division of Cardiology, Department of Pediatrics, The Children's Hospital at Montefiore, Bronx, New York.
authors.forename: Christine
authors.initials: C
authors.lastname: Capone
authors.affiliation: Division of Neonatology, Department of Pediatrics, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Melissa
authors.initials: M
authors.lastname: Vega
authors.affiliation: Division of Cardiology, Department of Pediatrics, The Children's Hospital at Montefiore, Bronx, New York.
authors.forename: Nicole
authors.initials: N
authors.lastname: Sutton
authors.affiliation: Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Mimi
authors.initials: M
authors.lastname: Kim
authors.affiliation: Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Division of Neonatology, Department of Pediatrics, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Mamta
authors.initials: M
authors.lastname: Fuloria
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000150:complications*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D005865:Gestational Age; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000453:epidemiology; D007223:Infant; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index