title: Involvement of Kallikrein-Kinin System on Cardiopulmonary Alterations and Inflammatory Response Induced by Purified Aah I Toxin from Scorpion Venom.
abstract: Bradykinins are released from kininogen by kallikrein. They increase capillary lung permeability after their binding to β1 and especially β2 receptors before being metabolized by kininase enzyme. This study was performed to evaluate cardiopulmonary damages and inflammatory response on injected rats with Aah I toxin of scorpion venom and the involvement of Kallikrein-Kinin system in this pathogenesis. Obtained results revealed that Aah I toxin induces inflammatory cell infiltration accompanied by cellular peroxidase activities, a release of cytokine levels, pulmonary and myocardial damage, with altered metabolic activities and imbalanced redox status. Administration of aprotinin (bradykinin inhibitor) and especially icatibant (bradykinin β2 receptor antagonist) seemed to be able to protect animals against the toxicity of Aah I; nevertheless, the use of captopril (kininase II inhibitor) reduced partially some cardiac disorders. These findings indicate that the kallikrein-kinin system may contribute to the physiopathological effect and lung edema formation induced by toxin, which suggests a potential use of drugs with significant anti-kinin properties.
authors.affiliation: USTHB, Faculty of Biological Sciences, Laboratory Cellular and Molecular Biology, Department Cellular and Molecular Biology, BP32, EL Alia, Bab Ezzouar, 16111, Algiers, Algeria.
authors.forename: Wafa
authors.initials: W
authors.lastname: Medjadba
authors.affiliation: Aix-Marseille University, CNRS UMR 7286 CRN2M, IFR Jean-Roche, Faculté de Médecine Nord, Bd Pierre Dramard, 13916, Marseille, Cedex 20, France.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Martin-Eauclaire
authors.affiliation: USTHB, Faculty of Biological Sciences, Laboratory Cellular and Molecular Biology, Department Cellular and Molecular Biology, BP32, EL Alia, Bab Ezzouar, 16111, Algiers, Algeria. flaraba@hotmail.com.
authors.forename: Fatima
authors.initials: F
authors.lastname: Laraba-Djebari
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001920:Bradykinin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D065094:Bradykinin B2 Receptor Antagonists / Q000494:pharmacology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002199:Capillary Permeability / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D047209:Eosinophil Peroxidase / Q000378:metabolism; D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007958:Leukocyte Count; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D011654:Pulmonary Edema / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D012604:Scorpion Venoms / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D065094:Bradykinin B2 Receptor Antagonists; D016207:Cytokines; D012604:Scorpion Venoms; C065314:scorpion toxin I, Androctonus; C065679:icatibant; D007611:Aprotinin; D002216:Captopril; D047209:Eosinophil Peroxidase; D009195:Peroxidase; D007610:Kallikreins; D001920:Bradykinin
keywords: Aah I neurotoxin; cardiopulmonary damage; inflammation; kallikrein-kinin system; lung permeability