title: Mast cells in meningiomas and brain inflammation.
abstract: BACKGROUND
  Research focus in neuro-oncology has shifted in the last decades towards the exploration of tumor infiltration by a variety of immune cells and their products. T cells, macrophages, B cells, and mast cells (MCs) have been identified.
  
  
  METHODS
  A systematic review of the literature was conducted by searching PubMed, EMBASE, Google Scholar, and Turning Research into Practice (TRIP) for the presence of MCs in meningiomas using the terms meningioma, inflammation and mast cells.
  
  
  RESULTS
  MCs have been detected in various tumors of the central nervous system (CNS), such as gliomas, including glioblastoma multiforme, hemangioblastomas, and meningiomas as well as metastatic brain tumors. MCs were present in as many as 90 % of all high-grade meningiomas mainly found in the perivascular areas of the tumor. A correlation between peritumoral edema and MCs was found.
  
  
  CONCLUSIONS
  Accumulation of MCs in meningiomas could contribute to the aggressiveness of tumors and to brain inflammation that may be involved in the pathogenesis of additional disorders.
authors.affiliation: Department of Neurosurgery, Kings College London, London, UK. stavrospolyzoidis@gmail.com.
authors.forename: Stavros
authors.initials: S
authors.lastname: Polyzoidis
authors.affiliation: Department of Pathology, AHEPA General Hospital, Thessaloniki, Greece. koletsa@med.auth.gr.
authors.forename: Triantafyllia
authors.initials: T
authors.lastname: Koletsa
authors.affiliation: Molecular Immunopharmacology and Drug Discovery, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Suite J304, Boston, MA, 02111, USA. smaro.panagiotidou@gmail.com.|Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA. smaro.panagiotidou@gmail.com.
authors.forename: Smaro
authors.initials: S
authors.lastname: Panagiotidou
authors.affiliation: Department of Neurosurgery, Kings College London, London, UK. k.ashkan@nhs.net.
authors.forename: Keyoumars
authors.initials: K
authors.lastname: Ashkan
authors.affiliation: Molecular Immunopharmacology and Drug Discovery, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Suite J304, Boston, MA, 02111, USA. theoharis.theoharides@tufts.edu.|Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA. theoharis.theoharides@tufts.edu.|Department of Internal Medicine, Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA. theoharis.theoharides@tufts.edu.|Department of Psychiatry, Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA. theoharis.theoharides@tufts.edu.|Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Suite J304, Boston, MA, 02111, USA. theoharis.theoharides@tufts.edu.
authors.forename: Theoharis C
authors.initials: TC
authors.lastname: Theoharides
mesh_terms: D000818:Animals; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D004660:Encephalitis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008407:Mast Cells / Q000473:pathology*; D008577:Meningeal Neoplasms / Q000276:immunology / Q000473:pathology*; D008579:Meningioma / Q000276:immunology / Q000473:pathology*