title: An economic analysis of adult hepatitis B vaccination in China.
abstract: OBJECTIVE
  With the universal infant hepatitis B vaccination (HepB) program, China has made remarkable achievements to prevent and control hepatitis B. In order to further reduce hepatitis B virus (HBV) infection, the Chinese government is considering implementing a widespread adult HBV vaccination campaign. We performed an economic analysis of two different adult HepB vaccination strategies for 21-59-years-olds: vaccination without screening and screening-based vaccination.
  
  
  METHODS
  Cost-benefit analyses were conducted. All 21-59-year-olds were divided into two groups: young adults (ages 21-39) and middle-aged adults (ages 40-59). Costs and benefits were estimated using the direct cost and societal (direct and indirect costs) perspectives. All costs and benefits were adjusted to 2014 US dollars, where future values were discounted at a 3% annual rate. We calculated benefit-cost ratios (BCRs) of the two vaccination strategies for the two different age groups. Sensitivity analyses varied key parameters within plausible ranges.
  
  
  RESULTS
  Among young adults, the direct and societal BCRs for a vaccination campaign with no screening would be 1.06 and 1.42; with a screening-based vaccination campaign, the model estimated the direct and societal BCRs would be 1.19 and 1.73. Among middle-aged adults, the direct and societal BCRs for a vaccination campaign without screening would be 0.59 and 0.59; with a screening-based vaccination campaign, the model estimated the direct and societal BCRs would be 0.68 and 0.73.
  
  
  CONCLUSIONS
  The results of our study support a HepB vaccination campaign for young adults. Additionally, a vaccination campaign with screening appeared to provide greater value than a vaccination without screening.
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address: niphepatitis@hotmail.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Fu-zhen
authors.initials: FZ
authors.lastname: Wang
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Guo-min
authors.initials: GM
authors.lastname: Zhang
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Fu-qiang
authors.initials: FQ
authors.lastname: Cui
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Wu
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Miao
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Xiao-jin
authors.initials: XJ
authors.lastname: Sun
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Liang
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address: llsdjn@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D002681:China; D003365:Costs and Cost Analysis; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000191:economics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014611:Vaccination / Q000191:economics*; D055815:Young Adult
chemical_list: D017325:Hepatitis B Vaccines
keywords: Adult; Hepatitis B; Vaccination