title: A Wireless Optogenetic Headstage with Multichannel Electrophysiological Recording Capability.
abstract: We present a small and lightweight fully wireless optogenetic headstage capable of optical neural stimulation and electrophysiological recording. The headstage is suitable for conducting experiments with small transgenic rodents, and features two implantable fiber-coupled light-emitting diode (LED) and two electrophysiological recording channels. This system is powered by a small lithium-ion battery and is entirely built using low-cost commercial off-the-shelf components for better flexibility, reduced development time and lower cost. Light stimulation uses customizable stimulation patterns of varying frequency and duty cycle. The optical power that is sourced from the LED is delivered to target light-sensitive neurons using implantable optical fibers, which provide a measured optical power density of 70 mW/mm² at the tip. The headstage is using a novel foldable rigid-flex printed circuit board design, which results into a lightweight and compact device. Recording experiments performed in the cerebral cortex of transgenic ChR2 mice under anesthetized conditions show that the proposed headstage can trigger neuronal activity using optical stimulation, while recording microvolt amplitude electrophysiological signals.
authors.affiliation: Department of Electrical and Computer Engineering, Université Laval, Quebec, QC G1V 0A6, Canada. gabriel.gagnon-turcotte.1@ulaval.ca.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Gagnon-Turcotte
authors.affiliation: Department of Electrical and Computer Engineering, Université Laval, Quebec, QC G1V 0A6, Canada. avakh.alireza@gmail.com.
authors.forename: Alireza Avakh
authors.initials: AA
authors.lastname: Kisomi
authors.affiliation: Department of Electrical and Computer Engineering, Université Laval, Quebec, QC G1V 0A6, Canada. reza.ameli@ymail.com.
authors.forename: Reza
authors.initials: R
authors.lastname: Ameli
authors.affiliation: Department of Electrical and Computer Engineering, Université Laval, Quebec, QC G1V 0A6, Canada. charles-olivier.dufresne-camaro.1@ulaval.ca.
authors.forename: Charles-Olivier Dufresne
authors.initials: CO
authors.lastname: Camaro
authors.affiliation: Doric Lenses Inc., Quebec, QC G1P 4N7, Canada. yoan@doriclenses.com.
authors.forename: Yoan
authors.initials: Y
authors.lastname: LeChasseur
authors.affiliation: Doric Lenses Inc., Quebec, QC G1P 4N7, Canada. luc@doriclenses.com.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Néron
authors.affiliation: Doric Lenses Inc., Quebec, QC G1P 4N7, Canada. paul@doriclenses.com.
authors.forename: Paul Brule
authors.initials: PB
authors.lastname: Bareil
authors.affiliation: Department of Electrical and Computer Engineering, Université Laval, Quebec, QC G1V 0A6, Canada. paul.fortier@GEL.ULAVAL.CA.
authors.forename: Paul
authors.initials: P
authors.lastname: Fortier
authors.affiliation: Institut Universitaire en Santé Mentale de Québec, Quebec, QC G1J 2G3, Canada. cyril.bories@gmail.com.
authors.forename: Cyril
authors.initials: C
authors.lastname: Bories
authors.affiliation: Institut Universitaire en Santé Mentale de Québec, Quebec, QC G1J 2G3, Canada. yves.dekoninck@neuro.ulaval.ca.|Centre d'Optique, Photonique et Laser (COPL), Université Laval, Quebec, QC G1V 0A6, Canada. yves.dekoninck@neuro.ulaval.ca.|Department of Psychiatry & Neuroscience, Université Laval, Quebec, QC G1V 0A6, Canada. yves.dekoninck@neuro.ulaval.ca.
authors.forename: Yves
authors.initials: Y
authors.lastname: de Koninck
authors.affiliation: Department of Electrical and Computer Engineering, Université Laval, Quebec, QC G1V 0A6, Canada. benoit.gosselin@gel.ulaval.ca.
authors.forename: Benoit
authors.initials: B
authors.lastname: Gosselin
mesh_terms: D000818:Animals; D062207:Brain-Computer Interfaces; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation*; D004867:Equipment Design; D051379:Mice; D008839:Microelectrodes; D062308:Optogenetics / Q000295:instrumentation*; D013686:Telemetry / Q000295:instrumentation*; D059015:Wireless Technology / Q000295:instrumentation*
keywords: brain-computer interfaces; electrophysiology; low-power biotelemetry; neural headstage; neural recording; optical stimulation; optogenetics; wireless sensor