title: Modulation of therapeutic sensitivity by human papillomavirus.
abstract: Human papillomaviruses (HPVs) are small double-stranded DNA viruses that pose significant public health concerns as the causative agent of approximately 5% of worldwide cancers. The HPV oncogenes E6 and E7 play key roles in carcinogenesis. In the last 15years there has been a significant increase in the incidence of HPV-related head and neck cancers arising primarily in the oropharynx. Patients with HPV-positive head and neck cancers (HNCs) have a significantly improved prognosis compared to those with HPV-negative disease. In this review we will discuss data suggesting how HPV oncogenes modulate both the intrinsic radiation sensitivity of HNCs and also have important effects upon the tumor microenvironment. Together, these findings contribute to the improved outcomes seen in patients with HPV-positive HNC.
authors.affiliation: Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, USA.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Swick
authors.affiliation: Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, USA.
authors.forename: Anirban
authors.initials: A
authors.lastname: Chatterjee
authors.affiliation: Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, USA.
authors.forename: Anna-Maria A
authors.initials: AM
authors.lastname: De Costa
authors.affiliation: Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, USA; University of Wisconsin Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, USA. Electronic address: rkimple@humonc.wisc.edu.
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Kimple
mesh_terms: D000818:Animals; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000821:virology*; D006801:Humans; D008297:Male; D009856:Oncogene Proteins, Viral; D027383:Papillomaviridae / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000473:pathology* / Q000532:radiotherapy*; D016896:Treatment Outcome
chemical_list: D009856:Oncogene Proteins, Viral
keywords: Anal cancer; Cervical cancer; HPV; Head and neck cancer; Human papillomavirus