title: Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects.
abstract: Mucinous tubular and spindle cell renal cell carcinoma is a rare, recently described variant of renal cell carcinoma characterized by an admixture of cuboidal cells in tubules and sheets of spindle cells, and variable amounts of mucinous stroma. It has been recognized as a distinct entity in the 2004 World Health Organization tumor classification. Since then, several dozen of these tumor have been reported with additional complementary morphologic characteristics, immunohistochemical profile, and molecular genetic features that have further clarified its clinicopathologic aspects. Although originally considered as a low grade renal cell carcinoma on the basis of its bland appearing nuclear features and indolent clinical course, mucinous tubular and spindle cell renal cell carcinoma has currently been proven to be a tumor that has a histological spectrum ranging from low to high grade that includes sarcomatoid differentiation. In this review, we present a detailed summary of the current knowledge regarding the clinicopathologic, immunohistochemical, molecular genetic, and prognostic characteristics, as well as differential diagnoses of mucinous tubular and spindle cell renal cell carcinoma.
authors.affiliation: Depatment of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China. zhaomingpathol@163.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Depatment of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China. xiangleihe2014@163.com.
authors.forename: Xiang-Lei
authors.initials: XL
authors.lastname: He
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, 310003, China. 552527563@qq.com.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Teng
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology*; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology*; D025202:Molecular Diagnostic Techniques; D060787:Neoplasm Grading; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology*; D010641:Phenotype; D011237:Predictive Value of Tests; D017154:Stromal Cells / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor