title: Targeting Breast Cancer Metastasis.
abstract: Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30-40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting.
authors.affiliation: Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ; Institute for Medical Engineering & Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.affiliation: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Mu
keywords: breast cancer; metastasis; metastatic traits; precision medicine; targeted therapy