title: P(═O)H to P-OH Tautomerism: A Theoretical and Experimental Study.
abstract: Phosphinylidene compounds R(1)R(2)P(O)H are important functionalities in organophosphorus chemistry and display prototropic tautomerism. Quantifying the tautomerization rate is paramount to understanding these compounds' tautomerization behavior, which may impact their reactivities in various reactions. We report a combined theoretical and experimental study of the initial tautomerization rate of a range of phosphinylidene compounds. Initial tautomerization rates are found to decrease in the order H3PO2 > Ph2P(O)H > (PhO)2P(O)H > PhP(O) (OAlk)H > AlkP(O)(OAlk)H ≈ (AlkO)2P(O)H, where "Alk" denotes an alkyl substituent. The combination of computational investigations with experimental validation establishes a quantitative measure for the reactivity of various phosphorus compounds, as well as an accurate predictive tool.
authors.affiliation: Department of Chemistry, Texas Christian University , Box 298860, Fort Worth, Texas 76129, United States.
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Janesko
authors.affiliation: Department of Chemistry, Texas Christian University , Box 298860, Fort Worth, Texas 76129, United States.
authors.forename: Henry C
authors.initials: HC
authors.lastname: Fisher
authors.affiliation: Department of Chemistry, Texas Christian University , Box 298860, Fort Worth, Texas 76129, United States.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Bridle
authors.affiliation: Department of Chemistry, Texas Christian University , Box 298860, Fort Worth, Texas 76129, United States.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Montchamp