title: [Chemotherapy of prostate cancer].
abstract: The prognosis of patients with advanced prostate cancer has improved over the last few years. In addition to the new antihormonal treatment, chemotherapy with agents such as docetaxel and cabazitaxel has contributed to the improved prognosis. After the introduction of abiraterone and enzalutamide, conventional chemotherapy seemed to become less important but the discussion about the use of chemotherapy for hormone-sensitive prostate cancer has gained attention again. Combining docetaxel with conventional androgen deprivation therapy (ADT) improves survival compared to ADT alone. In addition, docetaxel and cabazitaxel now represent the standard for first and second line therapy in patients with castration-resistant prostate cancer.
authors.affiliation: Klinik für Urologie und Kinderurologie, Universität des Saarlandes, Kirrbergerstr., 66421, Homburg/Saar, Deutschland. carsten.ohlmann@uks.eu.
authors.forename: C-H
authors.initials: CH
authors.lastname: Ohlmann
mesh_terms: D000726:Androgen Antagonists / Q000008:administration & dosage*; D000736:Androstenes / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001549:Benzamides; D000077143:Docetaxel; D004358:Drug Therapy / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D008297:Male; D009570:Nitriles; D010669:Phenylthiohydantoin / Q000008:administration & dosage / Q000031:analogs & derivatives; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists; D000736:Androstenes; D001549:Benzamides; D009570:Nitriles; D043823:Taxoids; D000077143:Docetaxel; D010669:Phenylthiohydantoin; C552428:cabazitaxel; C540278:enzalutamide; C089740:abiraterone
keywords: Cabazitaxel; Castration resistant prostate cancer; Docetaxel; Hormone sensitive prostate cancer; Survival