title: Circulating CD34-positive cells, glomerular filtration rate and triglycerides in relation to hypertension.
abstract: OBJECTIVE
  Serum triglycerides have been reported to be independently associated with the development of chronic kidney disease (CKD), which is known to play a role in vascular disturbance. On the other hand, circulating CD34-positve cells, including endothelial progenitor cells, are reported to contribute to vascular repair. However, no studies have reported on the correlation between triglycerides and the number of CD34-positive cells. Since hypertension is well known factor for vascular impairment, the degree of correlation between serum triglycerides and circulating CD34-positve cells should account for hypertension status.
  
  
  METHODS
  We conducted a cross-sectional study of 274 elderly Japanese men aged ≥ 60 years (range 60-79 years) undergoing general health checkups.
  
  
  RESULTS
  Multiple linear regression analysis of non-hypertensive subjects adjusting for classical cardiovascular risk factors showed that although triglyceride levels (1SD increments; 64 mg/dL) did not significantly correlate with glomerular filtration rate (GFR) (β = -2.06, p = 0.163), a significant positive correlation was seen between triglycerides and the number of circulating CD34-positive cells (β = 0.50, p = 0.004). In hypertensive subjects, a significant inverse correlation between triglycerides and GFR was observed (β = -2.66, p = 0.035), whereas no significant correlation between triglycerides and the number of circulating CD34-positive cells was noted (β = -0.004, p = 0.974).
  
  
  CONCLUSIONS
  Since endothelial progenitor cells (CD34-positive cells) have been reported to contribute to vascular repair, our results indicate that in non-hypertensive subjects, triglycerides may stimulate an increase in circulating CD34-positive cells (vascular repair) by inducing vascular disturbance.
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan. Electronic address: shimizuyuji@nagasaki-u.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimizu
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Shimpei
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Koyamatsu
authors.affiliation: Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Yamanashi
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Mako
authors.initials: M
authors.lastname: Nagayoshi
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kadota
authors.affiliation: Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan; Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D018952:Antigens, CD34 / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007564:Japan; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D051436:Renal Insufficiency, Chronic / Q000097:blood; D012307:Risk Factors; D013234:Stem Cells / Q000166:cytology; D014280:Triglycerides / Q000097:blood*
chemical_list: D018952:Antigens, CD34; D014280:Triglycerides
keywords: CD34-positive cell; Glomerular filtration rate; Hypertension; Triglycerides