title: [Novel biomarkers in renal cell carcinoma. Identification and functional characterization].
abstract: Due to advanced imaging techniques, renal cell carcinoma (RCC) is now identified earlier, often in localized stages. As a result, nephron-sparing surgical resection is possible in most cases. The development of new targeted therapies has changed the way metastatic RCC is treated. Despite this positive trend with improved survival rates and expanding treatment options, reliable biomarkers for better predicting disease course are lacking. These are urgently needed to enable personalized therapy based on the treatment-associated risks, the presence of comorbidities, and molecular tumor characteristics. We were able to show that proteins with a regulatory influence on apoptotic signal cascades represent not only promising prognostic markers, but also interesting targets for new therapeutic approaches. Furthermore, our data demonstrate that molecular tests are necessary to correctly classify a RCC with Xp11.2 translocation, since in addition to translocation, amplification can also result in TFE3 activation. Translational research with RCC biomarker identification and establishment, as well as molecular characterization and subtyping of RCCs is required to guide therapeutic decisions and enable personalized medicine in RCC patients.
authors.affiliation: Pathologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland. stephan.goeppinger@med.uni-heidelberg.de.
authors.forename: S
authors.initials: S
authors.lastname: Macher-Göppinger
mesh_terms: D017209:Apoptosis / Q000235:genetics; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D041321:Chromosomes, Human, X / Q000235:genetics; D004252:DNA Mutational Analysis; D005784:Gene Amplification / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D058990:Molecular Targeted Therapy; D057285:Precision Medicine; D011379:Prognosis; D015533:Transcriptional Activation / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D005819:Genetic Markers; C069203:TFE3 protein, human
keywords: Apoptosis; Biomarker, prognostic; Renal cancer mortality; Renal cell carcinoma; Signal cascades, apoptotic