title: Effect of enrofloxacin and chlorpyrifos on the levels of vitamins A and E in Wistar rats.
abstract: This study investigates the effects of enrofloxacin and chlorpyrifos, and their combination on vitamin A and E concentrations in the liver of rats. Results of this study indicated a reduction in the contents of vitamins A and E in the liver, which persisted for the entire period of the experiment. Vitamins A and E concentrations were slightly decreased (2-7%) in enrofloxacin-treated rats. In the group of rats intoxicated with chlorpyrifos, a significant decrease in the level of vitamin A was observed up to the 24th hour, and for vitamin E up to the 3rd day from the discontinuation of intoxication with the compounds under study. In the enrofloxacin-chlorpyrifos co-exposure group reduced vitamins A and E level was also noted. The greatest fall in vitamin A level was observed after 3h, while the contents of vitamin E decreased progressively up to the 3rd day. Changes in this group were less pronounced in comparison to the animals intoxicated with chlorpyrifos only.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, M. Oczapowskiego 14 Street, 10-719 Olsztyn, Poland. Electronic address: anspod@uwm.edu.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Spodniewska
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, M. Oczapowskiego 14 Street, 10-719 Olsztyn, Poland. Electronic address: darbar@uwm.edu.pl.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Barski
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, M. Oczapowskiego 14 Street, 10-719 Olsztyn, Poland. Electronic address: aleksandra.gizejewska@uwm.edu.pl.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Giżejewska
mesh_terms: D000818:Animals; D004390:Chlorpyrifos / Q000633:toxicity*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000032:analysis*; D014810:Vitamin E / Q000032:analysis*
chemical_list: D024841:Fluoroquinolones; D014801:Vitamin A; D014810:Vitamin E; D000077422:Enrofloxacin; D004390:Chlorpyrifos
keywords: Chlorpyrifos; Enrofloxacin; Oxidative stress; Vitamin A; Vitamin E