title: Controlled radical polymerization of an acrylamide containing L-alanine moiety via ATRP.
abstract: Homopolymerization of an optically active acrylamide having an amino acid moiety in the side chain, N-acryloyl-L-alanine (AAla) was carried out via atom transfer radical polymerization (ATRP) at room temperature using 2-hydroxyethyl-2'-methyl-2'-bromopropionate (HMB) or sodium-4-(bromomethyl)benzoate (SBB) as initiator in pure water, methanol/water mixture and pure methanol solvents. The polymerization reaction resulted in the optically active biocompatible amino acid-based homopolymer in good yield with narrow molecular weight distribution. The number average molecular weight increased with conversion and polydispersity was low. The structure and molecular weight of synthesized polymer were characterized by (1)H NMR, FT-IR spectroscopic techniques and size-exclusion chromatography.
authors.affiliation: Department of Chemistry, Yasouj University, Yasouj, 75918-74831, Islamic Republic of Iran. z.rafiee@mail.yu.ac.ir.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rafiee
mesh_terms: D020106:Acrylamide / Q000138:chemical synthesis* / Q000737:chemistry; D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: C000602257:N-acryloyl-L-alanine; D011108:Polymers; D020106:Acrylamide; D000409:Alanine
keywords: Atom transfer radical polymerization; Homopolymerization; Optically active