title: Recent advances on viral manipulation of NF-κB signaling pathway.
abstract: NF-κB transcription factors regulate the expression of hundreds of genes primarily involved in immune responses. Signaling events leading to NF-κB activation constitute a major antiviral immune pathway. To replicate and persist within their hosts, viruses have evolved diverse strategies to evade and exploit cellular NF-κB immune signaling cascades for their benefit. We summarize recent studies concerning viral manipulation of the NF-κB signaling pathway downstream of pattern recognition receptors. Signal transduction mediated by pattern recognition receptors is a research frontier for both infectious disease and innate immunology.
authors.affiliation: Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States.
authors.forename: Shanping
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States.
authors.forename: Arlet
authors.initials: A
authors.lastname: Minassian
authors.affiliation: Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States.
authors.forename: Junhua
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States. Electronic address: pinghui.feng@med.usc.edu.
authors.forename: Pinghui
authors.initials: P
authors.lastname: Feng
mesh_terms: D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D016328:NF-kappa B / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction; D014759:Viral Envelope Proteins / Q000276:immunology / Q000378:metabolism; D014764:Viral Proteins / Q000276:immunology / Q000378:metabolism; D014780:Viruses / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D016328:NF-kappa B; D051192:Receptors, Pattern Recognition; D014759:Viral Envelope Proteins; D014764:Viral Proteins