title: Genetic Testing in the Multidisciplinary Management of Melanoma.
abstract: Melanoma is increasing in incidence and represents an aggressive type of cancer. Efforts have focused on identifying genetic factors in melanoma carcinogenesis to guide prevention, screening, early detection, and targeted therapy. This article reviews the hereditary risk factors associated with melanoma and the known molecular pathways and genetic mutations associated with this disease. This article also explores the controversies associated with genetic testing and the latest advances in identifying genetic targets in melanoma, which offer promise for future application in the multidisciplinary management of melanoma.
authors.affiliation: Department of Cutaneous Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, SRB 4.24012, Tampa, FL 33612, USA; Bienes Comprehensive Cancer Center, Holy Cross Hospital, 4725 N Federal Highway, Fort Lauderdale, FL 33308, USA.
authors.forename: Omar M
authors.initials: OM
authors.lastname: Rashid
authors.affiliation: Department of Cutaneous Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, SRB 4.24012, Tampa, FL 33612, USA. Electronic address: jonathan.zager@moffitt.org.
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Zager
mesh_terms: D019468:Disease Management; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008545:Melanoma / Q000175:diagnosis* / Q000235:genetics*; D018570:Risk Assessment
keywords: Genetic targets; Genetic testing; Melanoma; Mutations; Screening; Somatic mutations; Targeted therapy