title: Highly robust hydrogels via a fast, simple and cytocompatible dual crosslinking-based process.
abstract: A highly robust hydrogel device made from a single biopolymer formulation is reported. Owing to the presence of covalent and non-covalent crosslinks, these engineered systems were able to (i) sustain a compressive strength of ca. 20 MPa, (ii) quickly recover upon unloading, and (iii) encapsulate cells with high viability rates.
authors.affiliation: 3B's Research group - Biomaterials, Biodegradables and Biomimetics - Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 BarcoGMR, Portugal. jmano@dep.uminho.pt.
authors.forename: Ana M S
authors.initials: AM
authors.lastname: Costa
authors.forename: João F
authors.initials: JF
authors.lastname: Mano
mesh_terms: D000178:Acrylamides / Q000737:chemistry / Q000528:radiation effects; D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D048271:Chitosan / Q000737:chemistry* / Q000528:radiation effects; D019245:Compressive Strength; D005994:Glycerophosphates / Q000737:chemistry / Q000528:radiation effects; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D017319:Photosensitizing Agents / Q000737:chemistry / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D000178:Acrylamides; D005994:Glycerophosphates; D020100:Hydrogels; D017319:Photosensitizing Agents; D048271:Chitosan; C045985:methacrylamide; C031463:beta-glycerophosphoric acid