title: Role of renal TRP channels in physiology and pathology.
abstract: Kidneys critically contribute to the maintenance of whole-body homeostasis by governing water and electrolyte balance, controlling extracellular fluid volume, plasma osmolality, and blood pressure. Renal function is regulated by numerous systemic endocrine and local mechanical stimuli. Kidneys possess a complex network of membrane receptors, transporters, and ion channels which allows responding to this wide array of signaling inputs in an integrative manner. Transient receptor potential (TRP) channel family members with diverse modes of activation, varied permeation properties, and capability to integrate multiple downstream signals are pivotal molecular determinants of renal function all along the nephron. This review summarizes experimental data on the role of TRP channels in a healthy mammalian kidney and discusses their involvement in renal pathologies.
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX, 77030, USA.|Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russian Federation.
authors.forename: Viktor
authors.initials: V
authors.lastname: Tomilin
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX, 77030, USA.
authors.forename: Mykola
authors.initials: M
authors.lastname: Mamenko
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX, 77030, USA.
authors.forename: Oleg
authors.initials: O
authors.lastname: Zaika
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX, 77030, USA. Oleh.M.Pochynyuk@uth.tmc.edu.
authors.forename: Oleh
authors.initials: O
authors.lastname: Pochynyuk
mesh_terms: D000818:Animals; D001692:Biological Transport; D002413:Cations, Divalent / Q000378:metabolism; D004198:Disease Susceptibility; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D007678:Kidney Glomerulus / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D040542:Mechanotransduction, Cellular; D005810:Multigene Family; D020033:Protein Isoforms; D050051:Transient Receptor Potential Channels / Q000235:genetics* / Q000378:metabolism*
chemical_list: D002413:Cations, Divalent; D020033:Protein Isoforms; D050051:Transient Receptor Potential Channels
keywords: Epithelial transport; TRPC6; TRPM6; TRPP2; TRPV4; TRPV5; glomerular disease; mechanosensitivity