title: Autonomic Modulation in Heart Failure: Ready for Prime Time?
abstract: It has been known for many decades that multiple abnormalities of the autonomic nervous system (ANS) are present in heart failure (HF). Moreover, many of the effective therapies currently used to treat HF have either direct or indirect effects on the ANS. While therapies that block over-activity of the sympathetic nervous system are now standard of care, much less well studied are therapies aimed at augmenting the parasympathetic nervous system. This review will cover recent and ongoing investigations targeting modulation of the ANS, especially highlighting new and ongoing studies directed toward augmenting parasympathetic mechanisms.
authors.affiliation: MetroHealth Campus of Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. mdunlap@metrohealth.org.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Dunlap
authors.affiliation: MetroHealth Campus of Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
authors.forename: Anju
authors.initials: A
authors.lastname: Bhardwaj
authors.affiliation: Saint Louis University School of Medicine, St. Louis, MO, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Hauptman
mesh_terms: D017763:Autonomic Denervation / Q000379:methods; D001341:Autonomic Nervous System / Q000503:physiopathology*; D017704:Baroreflex / Q000502:physiology; D002344:Carotid Body / Q000601:surgery; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D010275:Parasympathetic Nervous System / Q000503:physiopathology; D062187:Spinal Cord Stimulation / Q000379:methods; D055536:Vagus Nerve Stimulation / Q000379:methods
keywords: Autonomic nervous system; Carotid body denervation; Heart failure; Renal denervation; Vagal stimulation