title: Assessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections.
abstract: Achieving selective and sensitive carbohydrate-protein interactions (CPIs) using nanotechnology is an intriguing area of research. Here we demonstrate that the different shapes of gold nanoparticles (AuNPs) functionalized with monosaccharides tune the bacterial aggregations. The mechanism of aggregation revealed that the large number of surface interactions of rod shaped mannose-AuNPs with E. coli ORN 178 compared with spherical and star-shaped AuNPs exhibited higher avidity and sensitivity. Moreover, such sensitive binding can be used for effective inhibition of bacterial infection of cells.
authors.affiliation: Indian Institute of Science Education and Research, Pashan, Pune 411008, India. rkikkeri@iiserpune.ac.in.
authors.forename: Preeti Madhukar
authors.initials: PM
authors.lastname: Chaudhary
authors.forename: Sivakoti
authors.initials: S
authors.lastname: Sangabathuni
authors.forename: Raghavendra Vasudeva
authors.initials: RV
authors.lastname: Murthy
authors.forename: Ajay
authors.initials: A
authors.lastname: Paul
authors.forename: Hirekodathakallu V
authors.initials: HV
authors.lastname: Thulasiram
authors.forename: Raghavendra
authors.initials: R
authors.lastname: Kikkeri
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects* / Q000502:physiology; D004927:Escherichia coli Infections / Q000517:prevention & control; D005690:Galactose / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008358:Mannose / Q000737:chemistry / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D064347:Microscopy, Electrochemical, Scanning
chemical_list: D006046:Gold; D008358:Mannose; D005690:Galactose