title: Influence of Structural Parameters on the Self-Association Properties of Anti-HIV Catanionic Dendrimers.
abstract: The self-association properties of anti-HIV catanionic dendrimers as multivalent galactosylceramide (GalCer)-derived inhibitors are presented. The study was designed to elucidate the origin of the relatively high cytotoxicity values of these anti-HIV catanionic dendrimers, which have previously been found to exhibit in vitro anti-HIV activity in the submicromolar range. The physicochemical properties of these catanionic dendrimers were studied to tentatively correlate the structural parameters with self-association and biological properties. We can conclude from this study that the absence of correlation between the hydrophobicity and the cytotoxicity of the catanionic systems could be explained by the partial segregation of the different partners of the catanionic entities.
authors.affiliation: IMRCP, UMR 5623 CNRS, Université Paul Sabatier, 118, route de Narbonne, 31062, Toulouse cedex 9, France.|CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, BP 44099, 31077, Toulouse cedex 4, France.|Université de Toulouse, UPS, INPT, 31077, Toulouse cedex 4, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Perez-Anes
authors.affiliation: IMRCP, UMR 5623 CNRS, Université Paul Sabatier, 118, route de Narbonne, 31062, Toulouse cedex 9, France.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Rodrigues
authors.affiliation: CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, BP 44099, 31077, Toulouse cedex 4, France.|Université de Toulouse, UPS, INPT, 31077, Toulouse cedex 4, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Caminade
authors.affiliation: Max Planck Institute of Colloids and Interfaces, 14476, Potsdam, Germany.
authors.forename: Cristina
authors.initials: C
authors.lastname: Stefaniu
authors.affiliation: Institute of Chemistry, University of Potsdam, 14476, Potsdam, Germany.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Tiersch
authors.affiliation: CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, BP 44099, 31077, Toulouse cedex 4, France.|Université de Toulouse, UPS, INPT, 31077, Toulouse cedex 4, France.
authors.forename: Cédric-Olivier
authors.initials: CO
authors.lastname: Turrin
authors.affiliation: IMRCP, UMR 5623 CNRS, Université Paul Sabatier, 118, route de Narbonne, 31062, Toulouse cedex 9, France. blanzat@chimie.ups-tlse.fr.
authors.forename: Muriel
authors.initials: M
authors.lastname: Blanzat
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000378:metabolism; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D000067493:Dynamic Light Scattering; D005699:Galactosylceramides / Q000737:chemistry; D015699:HIV Envelope Protein gp120 / Q000037:antagonists & inhibitors / Q000378:metabolism; D015497:HIV-1 / Q000378:metabolism; D006801:Humans; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D050091:Dendrimers; D005699:Galactosylceramides; D015699:HIV Envelope Protein gp120; D013501:Surface-Active Agents; C514793:gp120 protein, Human immunodeficiency virus 1
keywords: anti-HIV; catanionic surfactants; dendrimers; galactosylceramide; glycolipids