title: Morphological Effect of Non-targeted Biomolecule-Modified MNPs on Reticuloendothelial System.
abstract: Magnetic nanoparticles (MNPs) with special morphology were commonly used as biomaterials, while morphological effects of non-targeted biomolecule-modified MNPs on biological behaviors were still unclear. In this research, spherical and rod-like Fe3O4 in a comparable size were synthesized and then surface-modified by bovine serum albumin (BSA) as a model of non-targeted biomolecule-modified MNPs. Morphological effects were featured by TEM and quantification of in vitro phagocytic uptake, as well as the in vivo quantification of particles in reticuloendothelial system (RES)-related organs of normal Kunming mice. For these non-targeted BSA-modified MNPs, intracellular distributions were the same, but the rod-like MNPs were more likely to be uptake by macrophages; furthermore, the BSA-modified MNPs gathered in RES-related organs soon after intravenous injection, but the rod-like ones were expelled from the lung more quickly and expelled from the spleen more slowly. These preliminary results may be referable if MNPs or other similar biomolecule-modified nanoparticles were used.
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. leelobster@126.com.|Shanghai Institute of Medical Imaging, Shanghai, China. leelobster@126.com.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. 275170956@qq.com.|Shanghai Institute of Medical Imaging, Shanghai, China. 275170956@qq.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. 934621031@qq.com.|Shanghai Institute of Medical Imaging, Shanghai, China. 934621031@qq.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. cdflyx@163.com.|Shanghai Institute of Medical Imaging, Shanghai, China. cdflyx@163.com.
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Cheng
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. zsxiuyan@sina.com.|Shanghai Institute of Medical Imaging, Shanghai, China. zsxiuyan@sina.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiu
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. shi.hongcheng@zs-hospital.sh.cn.|Shanghai Institute of Medical Imaging, Shanghai, China. shi.hongcheng@zs-hospital.sh.cn.
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Shi
keywords: Biodistribution; Cellular uptake; Magnetic nanoparticles; Morphological effects; Reticuloendothelial system