title: Ridge Preservation After Tooth Extraction With Buccal Bone Plate Deficiency Using Tunnel Structured β-Tricalcium Phosphate Blocks: A 2-Month Histologic Pilot Study in Beagle Dogs.
abstract: BACKGROUND
  Reduction in alveolar ridge volume is a direct consequence of tooth extraction. Tunnel β-tricalcium phosphate (β-TCP) blocks were manufactured from randomly organized tunnel-shaped β-TCP ceramic. Efficacy of these blocks compared to extraction alone for alveolar ridge preservation after tooth extraction with buccal bone deficiency was evaluated.
  
  
  METHODS
  Maxillary first premolars of six beagle dogs were extracted after removing the buccal bone, and bone defects of 4 × 4 × 5 mm (mesio-distal width × bucco-palatal width × depth) were created. Fresh extraction sockets with buccal bone defects were filled with tunnel β-TCP blocks at test sites. Two months after the operation, histologic and histometric evaluations were performed.
  
  
  RESULTS
  Regarding histologic sections, coronal and middle horizontal widths of the alveolar ridge were significantly greater at test sites (3.2 ± 0.5 and 3.6 ± 0.4 mm, respectively) than at control sites (1.2 ± 0.3 and 2.0 ± 0.6 mm, respectively). The amount of woven bone was significantly greater at test sites (62.4% ± 7.9%) than at control sites (26.8% ± 5.3%), although that of connective tissue and bone marrow was significantly greater at control sites (38.1% ± 6.2% and 16.0% ± 6.9%, respectively) than at test sites (10.7% ± 5.7% and 4.1% ± 2.2%, respectively). Regarding basic multicellular units, no statistically significant difference was found between the test and control sites (0.5% ± 0.1% and 0.6% ± 0.1%, respectively).
  
  
  CONCLUSIONS
  Tunnel β-TCP blocks represent an effective bone-graft material for alveolar ridge preservation in fresh extraction sockets with buccal bone defects.
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ikawa
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.|Division of Periodontology, Department of Oral Science, Graduate School of Dental Science, Kanagawa Dental University, Kanagawa, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Akizuki
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Matsuura
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Shu
authors.initials: S
authors.lastname: Hoshi
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Shujaa Addin
authors.initials: SA
authors.lastname: Ammar
authors.affiliation: Department of Educational Media Development, Institute for Library and Media Information Technology, Tokyo Medical and Dental University.
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Kinoshita
authors.affiliation: Oral Diagnosis and General Dentistry, University Hospital of Dentistry, Tokyo Medical and Dental University.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Oda
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Izumi
mesh_terms: D000539:Alveolar Process; D000818:Animals; D001860:Bone Plates; D004285:Dogs; D010865:Pilot Projects; D014081:Tooth Extraction; D020390:Tooth Socket
keywords: Alveolar ridge augmentation; beta-tricalcium phosphate; biocompatible materials; dogs; osteogenesis; tooth extraction