title: Second allogeneic transplantation for relapse of malignant disease: retrospective analysis of outcome and predictive factors by the EBMT.
abstract: In patients treated with allogeneic stem cell transplantation (SCT) for malignant disease who suffer from a relapse after the transplantation, the role of second allogeneic SCT is often uncertain. In a retrospective analysis, 2632 second allogeneic transplantations carried out for a relapse after the first transplantation were analyzed to define indications and identify predictive factors. Fifteen percent of the patients remained relapse-free until 5 years after the second SCT. Patients with CML had a better survival than patients with other diseases. In a multivariate analysis, factors associated with better survival were low disease burden, longer remission duration after the first transplantation, longer interval between the transplantations, younger age, absence of grade II-IV acute GvHD or chronic GvHD after the first transplantation, and later year of transplantation. The European Society for Blood and Marrow Transplantation risk score predicted the outcome. Using the same donor as in the first transplantation vs another donor had no predictive value for survival. Sibling donor was a favorable predictive factor. In conclusion, second allogeneic SCT offers a reasonable option especially for young patients with a long remission after the first transplantation and a low disease burden. The present findings do not support the usefulness of changing the donor for the second transplantation.
authors.affiliation: Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Ruutu
authors.affiliation: Department of Medical Statistics and Bioinformatics, Leiden University Medical Center/EBMT Statistical Unit, Leiden, The Netherlands.
authors.forename: L C
authors.initials: LC
authors.lastname: de Wreede
authors.affiliation: EBMT Data Office Leiden, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van Biezen
authors.affiliation: Department of Medical Statistics and Bioinformatics, Leiden University Medical Center/EBMT Statistical Unit, Leiden, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Brand
authors.affiliation: Hôpital Saint Antoine, Service d'Hématologie Clinique et de Thérapie Cellulaire; Université Pierre et Marie Curie; INSERM, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Department of Medicine V, University of Heidelberg, Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Dreger
authors.affiliation: Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Duarte
authors.affiliation: Department of Pediatrics, Stem Cell Transplantation Unit, St Anna Children's Hospital, Vienna, Austria.
authors.forename: C
authors.identifier: http://orcid.org/0000-0003-0369-8515
authors.initials: C
authors.lastname: Peters
authors.affiliation: Hôpital Saint Antoine, Service d'Hématologie Clinique et de Thérapie Cellulaire; Université Pierre et Marie Curie; INSERM, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Garderet
authors.affiliation: Medizinische Klinik und Poliklinik V, University of Heidelberg, Heidelberg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schönland
authors.affiliation: Hematology, Medical Faculty, University of Basel, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Gratwohl
authors.affiliation: Department of Hematology/Oncology and Hemostasiology, University of Leipzig, Leipzig, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Niederwieser
authors.affiliation: Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: de Witte
authors.affiliation: Department of Stem Cell Transplantation, University Cancer Centre Hamburg, Hamburg, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Kröger
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D064591:Allografts; D002908:Chronic Disease; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000209:etiology / Q000401:mortality; D019337:Hematologic Neoplasms / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D033581:Stem Cell Transplantation; D015996:Survival Rate