title: Possible Triggering Effect of Influenza Vaccination on Psoriasis.
abstract: Psoriasis is a chronic, recurrent, immune-mediated inflammatory disease and it can be provoked or exacerbated by a variety of different environmental factors, particularly infections and drugs. In addition, a possible association between vaccination and the new onset and/or exacerbation of psoriasis has been reported by a number of different authors. The aim of this study is to investigate the effects of influenza vaccination on patients with psoriasis. Here, we report the findings from 43 patients suffering from psoriasis (clinical phenotypes as mixed guttate/plaque lesions, palmoplantar or scalp psoriasis) whose diseases had been triggered after influenza vaccination applied in the 2009-2010 season. The short time intervals between vaccination and psoriasis flares in our patients and the lack of other possible triggers suggest that influenza vaccinations may have provocative effects on psoriasis. However, further large and controlled studies need to be carried out to confirm this relationship.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Inciraltı, 35340 Izmir, Turkey.
authors.forename: Ali Tahsin
authors.initials: AT
authors.lastname: Gunes
authors.affiliation: Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Inciraltı, 35340 Izmir, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Fetil
authors.affiliation: Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Inciraltı, 35340 Izmir, Turkey.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Akarsu
authors.affiliation: Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Inciraltı, 35340 Izmir, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozbagcivan
authors.affiliation: Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Inciraltı, 35340 Izmir, Turkey.
authors.forename: Lale
authors.initials: L
authors.lastname: Babayeva
mesh_terms: D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology; D029521:Alphainfluenzavirus / Q000145:classification / Q000276:immunology; D008297:Male; D011565:Psoriasis / Q000175:diagnosis / Q000209:etiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D007252:Influenza Vaccines