title: A model evaluation study for treatment planning of laser-induced thermal therapy.
abstract: A cross-validation analysis evaluating computer model prediction accuracy for a priori planning magnetic resonance-guided laser-induced thermal therapy (MRgLITT) procedures in treating focal diseased brain tissue is presented. Two mathematical models are considered. (1) A spectral element discretisation of the transient Pennes bioheat transfer equation is implemented to predict the laser-induced heating in perfused tissue. (2) A closed-form algorithm for predicting the steady-state heat transfer from a linear superposition of analytic point source heating functions is also considered. Prediction accuracy is retrospectively evaluated via leave-one-out cross-validation (LOOCV). Modelling predictions are quantitatively evaluated in terms of a Dice similarity coefficient (DSC) between the simulated thermal dose and thermal dose information contained within N = 22 MR thermometry datasets. During LOOCV analysis, the transient model's DSC mean and median are 0.7323 and 0.8001 respectively, with 15 of 22 DSC values exceeding the success criterion of DSC ≥ 0.7. The steady-state model's DSC mean and median are 0.6431 and 0.6770 respectively, with 10 of 22 passing. A one-sample, one-sided Wilcoxon signed-rank test indicates that the transient finite element method model achieves the prediction success criteria, DSC ≥ 0.7, at a statistically significant level.
authors.affiliation: a Department of Imaging Physics , M.D. Anderson Cancer Center, University of Texas , Houston , Texas , USA .|b Graduate School of Biomedical Sciences, University of Texas , Houston , Texas , USA .
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Fahrenholtz
authors.affiliation: c Department of Computational and Applied Mathematics , Rice University , Houston , Texas , USA .
authors.forename: Tim Y
authors.initials: TY
authors.lastname: Moon
authors.affiliation: c Department of Computational and Applied Mathematics , Rice University , Houston , Texas , USA .
authors.forename: Michael
authors.initials: M
authors.lastname: Franco
authors.affiliation: c Department of Computational and Applied Mathematics , Rice University , Houston , Texas , USA .
authors.forename: David
authors.initials: D
authors.lastname: Medina
authors.affiliation: d Department of Neurosurgery , Robert Wood Johnson Hospital , New Brunswick, New Jersey , USA , and.
authors.forename: Shabbar
authors.initials: S
authors.lastname: Danish
authors.affiliation: e BioTex, Inc. , Houston , Texas , USA.
authors.forename: Ashok
authors.initials: A
authors.lastname: Gowda
authors.affiliation: e BioTex, Inc. , Houston , Texas , USA.
authors.forename: Anil
authors.initials: A
authors.lastname: Shetty
authors.affiliation: a Department of Imaging Physics , M.D. Anderson Cancer Center, University of Texas , Houston , Texas , USA .
authors.forename: Florian
authors.initials: F
authors.lastname: Maier
authors.affiliation: a Department of Imaging Physics , M.D. Anderson Cancer Center, University of Texas , Houston , Texas , USA .|b Graduate School of Biomedical Sciences, University of Texas , Houston , Texas , USA .
authors.forename: John D
authors.initials: JD
authors.lastname: Hazle
authors.affiliation: a Department of Imaging Physics , M.D. Anderson Cancer Center, University of Texas , Houston , Texas , USA .|b Graduate School of Biomedical Sciences, University of Texas , Houston , Texas , USA .
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Stafford
authors.affiliation: c Department of Computational and Applied Mathematics , Rice University , Houston , Texas , USA .
authors.forename: Tim
authors.initials: T
authors.lastname: Warburton
authors.affiliation: a Department of Imaging Physics , M.D. Anderson Cancer Center, University of Texas , Houston , Texas , USA .|b Graduate School of Biomedical Sciences, University of Texas , Houston , Texas , USA .
authors.forename: David
authors.initials: D
authors.lastname: Fuentes
mesh_terms: D000465:Algorithms; D002138:Calibration; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053685:Laser Therapy; D008279:Magnetic Resonance Imaging; D008954:Models, Biological; D010347:Patient Care Planning
keywords: Bioheat transfer; MR temperature imaging; graphics processing unit (GPU); laser induced thermal therapy