title: Exploring Biological Motion Processing in Parkinson's Disease Using Temporal Dilation.
abstract: Biological motion (BM) perception is the compelling ability of the visual system to perceive complex animated movements effortlessly and promptly. A recent study has shown that BM can automatically lengthen perceived temporal duration independent of global configuration. The present study aimed mainly to investigate this temporal dilation effect of BM signals in Parkinson's disease (PD) patients. We used the temporal dilation effect as an implicit measure of visual processing of BM. In all, 32 PD patients (under off-therapy conditions) and 32 healthy controls (HCs) participated in our study. In each trial, an upright BM sequence and an inverted BM sequence were presented within an interval in the center of the screen. We tested both canonical and scrambled BM sequences; the scrambled ones were generated by disturbing the global configuration of the canonical ones but preserving exactly the same local motion components. Observers were required to make a verbal two-alternative forced choice response to indicate which interval (the first or the second) appeared longer. Statistical analyses were conducted on the points of subjective equality (PSEs). We found that the temporal dilation effect was significantly reduced for PD patients compared with HCs in both canonical and scrambled BM conditions. Moreover, no temporal dilation effects of scrambled BM were shown in both early- and late-stage PD patients, while the temporal dilation effect of canonical BM was relatively preserved in the early stages.
authors.affiliation: Department of Geriatric Medicine, Anhui Provincial Hospital, Hefei, Anhui Province, China.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Cao
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Ye
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Xingui
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Xianwen
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Yanghua
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Panpan
authors.initials: P
authors.lastname: Hu
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D004192:Discrimination, Psychological / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009038:Motion; D009039:Motion Perception / Q000502:physiology*; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D010775:Photic Stimulation
chemical_list: D000978:Antiparkinson Agents