title: Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory.
abstract: Massed training is less effective for long-term memory formation than the spaced training. The role of acetylation in synaptic plasticity and memory is now well established. However, the role of this important protein modification in synaptic plasticity induced by massed pattern of stimulation or memory induced by massed training is not well understood. Here we show that increasing the level of acetylation enhances long-term potentiation induced by massed pattern of high frequency stimulation. Furthermore, enhancing acetylation level facilitates long-term memory by massed training. Thus, increasing acetylation level facilitates synaptic plasticity and memory by massed patterns.
authors.affiliation: National Brain Research Centre, Manesar, Haryana 122051, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Pandey
authors.affiliation: National Brain Research Centre, Manesar, Haryana 122051, India.
authors.forename: Kaushik P
authors.initials: KP
authors.lastname: Sharma
authors.affiliation: National Brain Research Centre, Manesar, Haryana 122051, India sharmas@nbrc.ac.in.
authors.forename: Shiv K
authors.initials: SK
authors.lastname: Sharma
mesh_terms: D000818:Animals; D020148:Butyric Acid / Q000494:pharmacology; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000502:physiology*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006655:Histone Deacetylases / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D057567:Memory, Long-Term / Q000187:drug effects / Q000502:physiology*
chemical_list: D056572:Histone Deacetylase Inhibitors; D020148:Butyric Acid; D006655:Histone Deacetylases