title: Palliation of Extensive Metastatic Bone Disease With 223Ra-Dichloride α-Particle Therapy in a Patient With Malignant Hereditary Paraganglioma-Pheochromocytoma Syndrome With SDHB Mutation.
abstract: A 26-year-old woman with a 5-year history of metastatic paraganglioma due to hereditary paraganglioma-pheochromocytoma syndrome with SDHB mutation, who had failed multiple treatment regimens and had transfusion dependent pancytopenia, presented with progressive liver and bone metastases. She was unable to sleep due to painful skull metastases and had severe weakness in her extremities that limited her mobility and daily activities. She was treated with 2 doses of Ra-dichloride (Xofigo, Ra) and had a dramatic improvement in pain control, mobility, and overall quality of life for 8 weeks, before passing away from pulmonary hemorrhage.
authors.affiliation: From the Departments of *Diagnostic Imaging and †Medical Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.
authors.forename: William
authors.initials: W
authors.lastname: Makis
authors.forename: Karey
authors.initials: K
authors.lastname: McCann
authors.forename: Alexander J B
authors.initials: AJ
authors.lastname: McEwan
authors.forename: Michael B
authors.initials: MB
authors.lastname: Sawyer
mesh_terms: D000328:Adult; D000512:Alpha Particles / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D005260:Female; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy*; D010166:Palliative Care; D010235:Paraganglioma / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy*; D011868:Radioisotopes / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011883:Radium / Q000627:therapeutic use*; D013385:Succinate Dehydrogenase / Q000235:genetics*
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; C108095:SDHB protein, human; D013385:Succinate Dehydrogenase; C581106:radium Ra 223 dichloride; D011883:Radium