title: Intra-Operative Contrast Cholangiography in Living Donor Liver Transplantation: The ISMETT Experience.
abstract: BACKGROUND
  We evaluated the clinical impact of donor biliary anatomy discrepancies (DBAD) achieved by comparing pre-operative evaluation obtained with magnetic resonance (MR)/magnetic resonance cholangiopancreatography (MRCP) imaging, with intra-operative cholangiography (IOC) on the living related liver donor (LDLT) and recipient.
  
  
  METHODS
  This single-center, retrospective study included 97 consecutive adult-to-adult (A2A) LDLT performed in our hospital in the last 12 years. Donor sex and age, living donors with biliary and/or vascular anomalies, recipient age, sex, primary etiology, re-transplantation, Model of End-Stage Liver Disease score, co-morbidities, arterial and biliary recipient complications assessed on the basis of clinical follow-up were collected and analyzed for significance through the use of a multivariate linear regression model.
  
  
  RESULTS
  Biliary complications in the donor (DBC) were detected in 8 (8.2%) cases. Biliary complications in the recipients (RBC) were detected in 38 (39%) cases. DBADs were found in 32 (33%) cases and resulted strictly related to RBC (P = .05).
  
  
  CONCLUSIONS
  After adjusting for co-variables, results of the linear regression analysis confirmed that DBAD is an independent predictor of RBC, but it is not significantly associated with vascular complications or patient survival. We showed that RBCs after LDLT were influenced by DBAD.
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Pagano
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Cintorino
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Li Petri
authors.affiliation: Division of General Surgery, Foundation I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Paci
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tropea
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Ricotta
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Bonsignore
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Saffioti
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Spada
authors.affiliation: Division of Radiology, ISMETT, UPMC in Italy, Palermo, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Miraglia
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy.
authors.forename: B G
authors.initials: BG
authors.lastname: Gridelli
authors.affiliation: Division of Abdominal and Transplantation Surgery, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center (UPMC) in Italy, Palermo, Italy. Electronic address: sgruttadauria@ismett.edu.
authors.forename: S
authors.initials: S
authors.lastname: Gruttadauria
mesh_terms: D000328:Adult; D001652:Bile Ducts / Q000002:abnormalities*; D002758:Cholangiography / Q000379:methods*; D049448:Cholangiopancreatography, Magnetic Resonance; D003287:Contrast Media; D058625:End Stage Liver Disease / Q000601:surgery*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D019520:Living Donors; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D066027:Transplant Recipients
chemical_list: D003287:Contrast Media