title: Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents.
abstract: In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, ¹H-NMR, (13)C-NMR, MS and elemental analyses. All compounds were screened for their antibacterial, antifungal and antiproliferative activity. Some of the synthesized derivatives have displayed promising biological activity.
authors.affiliation: Department of Chemistry, Faculty of Sciences, Taibah University, P. O. Box 344, Al-Madinah Al-Munawarah 30002, Saudi Arabia. nadjetrezki@yhaoo.fr.|Laboratoire de Chimie & Electrochimie des Complexes Métalliques (LCECM) USTO-MB, Department of Chemistry, Faculty of Sciences, University of Sciences and Technology Mohamed Boudiaf, P. O. Box 1505, El M'nouar, Oran 31000, Algeria. nadjetrezki@yhaoo.fr.
authors.forename: Nadjet
authors.initials: N
authors.lastname: Rezki
authors.affiliation: Department of Chemistry, Faculty of Sciences, Taibah University, P. O. Box 344, Al-Madinah Al-Munawarah 30002, Saudi Arabia. mjooooda_88@hotmail.com.
authors.forename: Amjad M
authors.initials: AM
authors.lastname: Al-Yahyawi
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan. S.Bardaweel@ju.edu.jo.
authors.forename: Sanaa K
authors.initials: SK
authors.lastname: Bardaweel
authors.affiliation: Department of Chemistry, Faculty of Sciences, Taibah University, P. O. Box 344, Al-Madinah Al-Munawarah 30002, Saudi Arabia. ffs_chem334@hotmail.com.
authors.forename: Fawzia F
authors.initials: FF
authors.lastname: Al-Blewi
authors.affiliation: Department of Chemistry, Faculty of Sciences, Taibah University, P. O. Box 344, Al-Madinah Al-Munawarah 30002, Saudi Arabia. aouadmohamedreda@yahoo.fr.|Laboratoire de Chimie & Electrochimie des Complexes Métalliques (LCECM) USTO-MB, Department of Chemistry, Faculty of Sciences, University of Sciences and Technology Mohamed Boudiaf, P. O. Box 1505, El M'nouar, Oran 31000, Algeria. aouadmohamedreda@yahoo.fr.
authors.forename: Mohamed R
authors.initials: MR
authors.lastname: Aouad
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D010069:Oxadiazoles / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000737:chemistry*; D013830:Thiadiazoles / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D010069:Oxadiazoles; D012545:Schiff Bases; D013830:Thiadiazoles; D014230:Triazoles; C058949:1,3,4-thiadiazole; C583463:1,3,4-oxadiazole; C045575:1,2,4-triazole
keywords: 1,2,4-triazole; 1,3,4-oxadiazole; 1,3,4-thiadiazole; Schiff base; antimicrobial activity; antitumor activity