title: Glutathione-S-transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis in Chinese populations.
abstract: In view of the controversies surrounding the glutathione-S-transferases (GST) M1/T1-endometriosis association, a meta-analysis of the GSTM1/GSTT1 genetic association studies of endometriosis was performed in Chinese populations. PubMed, Springer Link, OvidSP, and Chinese databases were searched for related studies. A total of nine studies on GSTM1-endometriosis involved 874 cases and 997 controls, and five studies on GSTT1 involved 404 cases and 513 controls were included in this meta-analysis. Overall, the null genotype of GSTM1/GSTT1 was significantly related to endometriosis risk in Chinese populations (GSTM1, OR = 2.21, 95% CI: 1.22-4.01; GSTT1, OR = 2.31, 95% CI: 1.34-3.99). In subgroup analyses stratified by ethnicity and source of controls, the same results were observed in Chinese Han and population-based studies. The sensitivity analysis confirmed the reliability and stability of the meta-analysis. No publication bias was found among studies by Egger's test. In conclusion, our meta-analysis supports that the GSTM1/GSTT1 null genotype might contribute to individual susceptibility to endometriosis in Chinese populations, especially in Chinese Han.
authors.affiliation: a Department of Central Laboratory , Hainan Province People's Hospital , Haikou, Hainan Province , China .|b College of Agriculture, Hainan University , Haikou, Hainan Province , China .
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Chen
authors.affiliation: c Department of Hepatobiliary Surgery , Hainan Province People's Hospital , Haikou, Hainan Province , China , and.
authors.forename: Da-Feng
authors.initials: DF
authors.lastname: Xu
authors.affiliation: a Department of Central Laboratory , Hainan Province People's Hospital , Haikou, Hainan Province , China .
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Xu
authors.affiliation: d Department of Breast Surgery , Hainan Province People's Hospital , Haikou, Hainan Province , China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yao
authors.affiliation: a Department of Central Laboratory , Hainan Province People's Hospital , Haikou, Hainan Province , China .
authors.forename: Sheng-Miao
authors.initials: SM
authors.lastname: Fu
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1
keywords: Endometriosis; GSTM1; GSTT1; glutathione-S-transferase; meta-analysis; polymorphism