title: Olfactory Bulbectomy Leads to the Development of Epilepsy in Mice.
abstract: There is a clear link between epilepsy and depression. Clinical data demonstrate a 30-35% lifetime prevalence of depression in patients with epilepsy, and patients diagnosed with depression have a three to sevenfold higher risk of developing epilepsy. Traditional epilepsy models partially replicate the clinical observations, with the demonstration of depressive traits in epileptic animals. Studies assessing pro-epileptogenic changes in models of depression, however, are more limited. Here, we examined whether a traditional rodent depression model--bilateral olfactory bulbectomy--predisposes the animals towards the development of epilepsy. Past studies have demonstrated increased neuronal excitability after bulbectomy, but continuous seizure monitoring had not been conducted. For the present study, we monitored control and bulbectomized animals by video-EEG 24/7 for approximately two weeks following the surgery to determine whether they develop spontaneous seizures. All seven bulbectomized mice exhibited seizures during the monitoring period. Seizures began about one week after surgery, and occurred in clusters with severity increasing over the monitoring period. These results suggest that olfactory bulbectomy could be a useful model of TBI-induced epilepsy, with advantages of relatively rapid seizure onset and a high number of individuals developing the disease. The model may also be useful for investigating the mechanisms underlying the bidirectional relationship between epilepsy and depression.
authors.affiliation: Department of Anesthesia, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America.
authors.forename: Raymund Y K
authors.initials: RY
authors.lastname: Pun
authors.affiliation: Division of Neurocritical Care, University of Cincinnati Medical Center, Cincinnati, OH, United States of America.
authors.forename: Katrina
authors.initials: K
authors.lastname: Peariso
authors.affiliation: Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America.
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Holland
authors.affiliation: Department of Anesthesia, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Lian
authors.affiliation: Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America; Departments of Anesthesia and Pediatrics, University of Cincinnati, Cincinnati, OH, United States of America.
authors.forename: Steve C
authors.initials: SC
authors.lastname: Danzer
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009830:Olfactory Bulb / Q000601:surgery*