title: Impact of single-dose nandrolone decanoate on gonadotropins, blood lipids and HMG CoA reductase in healthy men.
abstract: The aim was to study the effect and time profile of a single dose of nandrolone decanoate (ND) on gonadotropins, blood lipids and HMG CoA reductase [3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR)] in healthy men. Eleven healthy male participants aged 29-46 years were given a single dose of 150 mg ND as an intramuscular dose of Deca Durabol®, Organon. Blood samples for sex hormones, lipids and HMGCR mRNA analysis were collected prior to ND administration day 0, 4 and 14. A significant suppression of luteinising hormone (LH) and follicle-stimulating hormone (FSH) was seen after 4 days. Total testosterone and bioavailable testosterone level decreased significantly throughout the observed study period. A small but significant decrease in sexual hormone-binding globulin (SHBG) was seen after 4 days but not after 14 days. Total serum (S)-cholesterol and plasma (P)-apolipoprotein B (ApoB) increased significantly after 14 days. In 80% of the individuals, the HMGCR mRNA level was increased 4 days after the ND administration. Our results show that a single dose of 150 mg ND increases (1) HMGCR mRNA expression, (2) total S-cholesterol and (3) P-ApoB level. The long-term consequences on cardiovascular risk that may appear in users remain to be elucidated.
authors.affiliation: Division of Clinical Pharmacology, Department of Laboratory Medicine/Huddinge, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden.
authors.forename: N
authors.initials: N
authors.lastname: Gårevik
authors.affiliation: Division of Clinical Pharmacology, Department of Laboratory Medicine/Huddinge, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Börjesson
authors.affiliation: Division of Clinical Pharmacology, Department of Laboratory Medicine/Huddinge, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Choong
authors.affiliation: Division of Clinical Pharmacology, Department of Laboratory Medicine/Huddinge, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Ekström
authors.affiliation: Department of Medicine/Huddinge, Karolinska Institute and Centre for Andrology and Sexual Medicine, Karolinska University Hospital, Huddinge, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Lehtihet
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001055:Apolipoproteins B / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009277:Nandrolone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077603:Nandrolone Decanoate; D012333:RNA, Messenger / Q000097:blood / Q000235:genetics; D012307:Risk Factors
chemical_list: D045930:Anabolic Agents; D001055:Apolipoproteins B; D006062:Gonadotropins; D008055:Lipids; D012333:RNA, Messenger; D009277:Nandrolone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002784:Cholesterol; C553220:HMGCR protein, human; D006903:Hydroxymethylglutaryl CoA Reductases; D000077603:Nandrolone Decanoate
keywords: Blood lipids; HMG CoA reductase; gonadotropins; nandrolone decanoate