title: The Prognostic Value of Soluble Intercellular Adhesion Molecule 1 Plasma Level in Children With Acute Lung Injury.
abstract: OBJECTIVE
  The objective of this study was to evaluate the prognostic significance of soluble intercellular adhesion molecule 1 (sICAM-1) measurement in plasma for the prediction of outcome of acute lung injury (ALI) in children that may allow early recognition of critical cases.
  
  
  METHODS
  The study was performed as a prospective, controlled cohort study involving 40 children with ALI and 30 healthy children. The plasma level of sICAM-1 was measured at days 1 and 3 of development of ALI for the patient group and measured only once for the control group. C-Reactive protein was measured in both groups on day 1 only.
  
  
  RESULTS
  There was significant increase in sICAM-1 in the patient group than in the control group ( P = .001*). The mortality rate reached 55% in children with ALI. The ceased group had significantly higher plasma sICAM-1 levels both at days 1 and 3 than the survived group ( P < .001*), and there was positive correlation between plasma sICAM-1 level and both duration of mechanical ventilation and the death rate, but more significant correlation was observed with plasma sICAM-1 levels at day 3 than day 1.
  
  
  CONCLUSIONS
  Plasma sICAM-1 level served as a good predictor biomarker for both mechanical ventilation duration and the mortality risk in children with ALI.
authors.affiliation: 1 Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Al-Biltagi
authors.affiliation: 1 Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt.
authors.forename: Ahmed Ahmed Abd ElBasset
authors.initials: AAAE
authors.lastname: Abo-Elezz
authors.affiliation: 1 Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt.
authors.forename: Khaled Talaat
authors.initials: KT
authors.lastname: Abu-Ela
authors.affiliation: 2 Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
authors.forename: Ghada Abudelmomen
authors.initials: GA
authors.lastname: Suliman
authors.affiliation: 1 Pediatric Department, Faculty of Medicine, Medical Complex, Tanta University, Tanta, Egypt.
authors.forename: Tamer Gomaa Hassan
authors.initials: TGH
authors.lastname: Sultan
mesh_terms: D055371:Acute Lung Injury / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1
keywords: C-reactive protein; acute lung injury; acute respiratory distress syndrome; children; prognosis; sICAM-1; soluble intercellular adhesion molecule 1