title: Preparation and Characterization of Folate Targeting Magnetic Nanomedicine Loaded with Gambogenic Acid.
abstract: To engineer multifunctional nanomedicines for simultaneous imaging and therapy of cancer cells, we have prepared Gambogenic acid (GNA) loaded folic acid (FA) armed MNPs (FA-GNA-MNPs) to target the folate receptor (FR) positive cancer cells. The FA-GNA-MNPs have been prepared by a facile method, which have been further characterized by SEM, TEM, IR and UV-vis spectra. And the cytotoxicity of FA-GNA-MNPs to HeLa and A549 cells was assessed using the MTT assay. The FA-GNA-MNPs (with loading efficiency of 4.35%) showed sustained liberation of GNA molecules (with 73.46% release in 96 h). The mean particle diameter (MD) of FA-GNA-MNPs and the polydispersity index (PDI) are 254.3 nm and 0.139, respectively. The cytotoxicity of free GNA and FA-GNA-MNPs toward HeLa cells showed that FA-GNA-MNPs was more cytotoxic than GNA. Based on these findings, it suggests that FA-GNA-MNPs would be as a novel multifunctional nanomedicine/theranostic for concurrent targeting, imaging and therapy of the FR-positive cancer cells.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Li Li
authors.initials: LL
authors.lastname: Yang
authors.forename: Chen Yin
authors.initials: CY
authors.lastname: Wang
authors.forename: Jin Pei
authors.initials: JP
authors.lastname: Chen
authors.forename: Shan Shan
authors.initials: SS
authors.lastname: Wang
authors.forename: Shu Jun
authors.initials: SJ
authors.lastname: Wang
authors.forename: Ya Jun
authors.initials: YJ
authors.lastname: Chen
authors.forename: Dian Lei
authors.initials: DL
authors.lastname: Wang
authors.forename: He Ping
authors.initials: HP
authors.lastname: Huang
mesh_terms: D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D058973:Folate Receptors, GPI-Anchored / Q000819:agonists*; D005492:Folic Acid / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003603:Cytotoxins; D058973:Folate Receptors, GPI-Anchored; D014966:Xanthenes; D005492:Folic Acid; C045863:neo-gambogic acid