title: Antimicrobials therapy of anaerobic infections.
abstract: Anaerobes predominant in the normal human skin and mucous membranes bacterial flora are often a cause of endogenous infections. Anaerobic bacteria are difficult to isolate from infectious sites, and are often overlooked. Anaerobic infections caused by anaerobes can occur in all body sites, including the central nervous system (CNS), oral cavity, head and neck, chest, abdomen, pelvis, skin and soft tissues. The treatment of these infections is complicated by the slow growth of these organisms, their polymicrobial nature and the growing resistance of anaerobes to antimicrobials agents. Antimicrobials are frequently the only form of therapy needed, but in others, they are an important adjunct to surgical drainage and correction of pathology. Because anaerobes are often recovered with aerobic and facultative bacteria, the chosen antimicrobials should cover all pathogens. The antimicrobials effective against anaerobic organisms are metronidazole, carbapenems, combinations of a beta-lactam and a beta-lactamase inhibitor, chloramphenicol, tigecycline and clindamycin.
authors.affiliation: a Department of Pediatrics , Georgetown University School of Medicine , Washington , DC , USA.
authors.forename: Itzhak
authors.initials: I
authors.lastname: Brook
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents
keywords: Anaerobes; Antibiotics; Antimicrobial resistance; Bacteroides fragilis