title: Anticancer Opportunity Created by Loss of Tumor Suppressor Genes.
abstract: Deletion of oncosuppressors occurs frequently in the cancer genome. A great deal of effort has been made to therapeutically restore the lost function of oncosuppressors, with little clinically translatable success, however. Reassuringly, besides the disappointing restoration endeavors, oncosuppressor loss can be therapeutically exploited in several other ways, such as the "synthetic lethality" strategies and the "therapeutic vulnerability" created by codeletion of neighboring genes. The study by Liu et al showed that codeletion of p53 and a neighboring essential gene POLR2A rendered colon cancer cells highly sensitive to further inhibition of POLR2A both in vitro and in vivo In recent years, several studies have reported similar phenomenon in a wide range of cancer types. In this focus article, we will introduce several kinds of anticancer opportunities created by the loss of oncosuppressors and discuss their mechanisms. Given the frequency of oncosuppressor loss in cancer, its therapeutic exploitation rather merits further investigation and may open a new window for oncotherapy.
authors.affiliation: The Reproductive Center, Jiangsu Huai'an Maternity and Children Hospital, Huai'an, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Hui-Ying
authors.affiliation: Department of Clinical Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Da-Hong
authors.affiliation: Department of Rehabilitation, The Affiliated Huai'an Hospital of Xuzhou Medical College and The Second People's Hospital of Huai'an, Huai'an, China luzg88@163.com.
authors.forename: Ji
authors.initials: J
authors.lastname: Li-Juan
authors.affiliation: Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China 189@whu.edu.cn.
authors.forename: Lu
authors.initials: L
authors.lastname: Xiao-Jie
mesh_terms: D017353:Gene Deletion; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D016678:Genome / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D025521:Tumor Suppressor Proteins
keywords: colon cancer; genomic deletion; oncosuppression; synthetic lethality; therapeutic vulnerability