title: The Influence of Urinary Concentrations of Organophosphate Metabolites on the Relationship between BMI and Cardiometabolic Health Risk.
abstract: The objective was to determine whether detectable levels of OP metabolites influence the relationship between BMI and cardiometabolic health. This cross-sectional study was conducted using 2227 adults from the 1999-2008 NHANES datasets. Urinary concentrations of six dialkyl phosphate metabolites were dichotomized to above and below the detection limit. Weighted multiple regression analysis was performed adjusting for confounding variables. Independent of BMI, individuals with detectable metabolites had higher diastolic blood pressure (for dimethylphosphate, diethylphosphate, and diethyldithiophosphate; P < 0.05), lower HDL (for diethyldithiophosphate; P = 0.02), and higher triglyceride (for dimethyldithiophosphate; P = 0.05) than those below detection. Contrarily, those with detectable dimethylthiophosphate had better LDL, HDL, and total cholesterol, independent of BMI. Individuals at a higher BMI range who had detectable diethylphosphate (interaction: P = 0.03) and diethylthiophosphate (interaction: P = 0.02) exhibited lower HDL, while little difference existed between OP metabolite detection statuses at lower BMIs. Similarly, individuals with high BMIs and detectable diethylphosphate had higher triglyceride than those without detectable levels, while minimal differences between diethylphosphate detection statuses were observed at lower BMIs (interaction: P = 0.02). Thus, cardiometabolic health outcome differs depending on the specific OP metabolite being examined, with higher BMIs amplifying health risk.
authors.affiliation: School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Ranjbar
authors.affiliation: School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Rotondi
authors.affiliation: School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3.
authors.forename: Chris I
authors.initials: CI
authors.lastname: Ardern
authors.affiliation: School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Kuk
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000652:urine*; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects* / Q000517:prevention & control; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000009:adverse effects / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000652:urine*; D009749:Nutrition Surveys; D009765:Obesity / Q000453:epidemiology / Q000517:prevention & control / Q000652:urine*; D010755:Organophosphates / Q000009:adverse effects / Q000652:urine*; D010575:Pesticides / Q000009:adverse effects / Q000652:urine*
chemical_list: D004785:Environmental Pollutants; D010755:Organophosphates; D010575:Pesticides