title: Efficacy of early intravenous bolus oxycodone or fentanyl in emergence from general anaesthesia and postoperative analgesia following laparoscopic cholecystectomy: A randomized trial.
abstract: OBJECTIVE
  To compare prospectively the efficacy of early intravenous bolus of oxycodone or fentanyl in providing analgesia at emergence from general anaesthesia following laparoscopic cholecystectomy.
  
  
  METHODS
  Patients were randomly assigned to receive either 0.08 mg/kg oxycodone (Group O) or 1 µg/kg fentanyl (Group F), 20 min before the end of surgery. Postoperative pain was evaluated using a visual analogue scale (VAS). The time to first postoperative analgesic dose, requirement for analgesia and side-effects were assessed in the postanaesthesia care unit (PACU).
  
  
  RESULTS
  The VAS scores at 0 min and 30 min and requirement for analgesia were significantly lower in Group O (n = 28) than in Group F (n = 26). The time to first analgesia dose was significantly longer in Group O than Group F. There were no significant between-group differences in the incidence of side-effects.
  
  
  CONCLUSIONS
  Oxycodone relieves immediate postoperative pain significantly better than fentanyl, and is not associated with an increase in side-effects in patients undergoing laparoscopic cholecystectomy.
authors.affiliation: Department of Dental Anaesthesiology, Seoul National University Dental Hospital, Seoul, Republic of Korea.
authors.forename: Yoon-Ji
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: Department of Anaesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Republic of Korea.
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Park
authors.affiliation: Department of Anaesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Republic of Korea.
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Kwon
authors.affiliation: Department of Anaesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Republic of Korea.
authors.forename: Jae-Moon
authors.initials: JM
authors.lastname: Choi
authors.affiliation: Department of Anaesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Republic of Korea ylee@amc.seoul.kr.
authors.forename: Yu-Mi
authors.initials: YM
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000698:Analgesia; D000768:Anesthesia, General; D001794:Blood Pressure; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects; D003710:Demography; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006339:Heart Rate; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010098:Oxycodone / Q000008:administration & dosage*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011182:Postoperative Care; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010098:Oxycodone; D005283:Fentanyl
keywords: Oxycodone; laparoscopic cholecystectomy; postoperative pain