title: [Increased expression of IL-16 in mouse skin allograft].
abstract: OBJECTIVE
  To detect the expression of interleukin 16 (IL-16) in skin allografts of recipient mice and the serum level of IL-16.
  
  
  METHODS
  Two different mouse models of skin allografts were used: the isotransplant group (C57BL/6--C57BL/6, n=45) and the allotransplantation group (BALB/c--C57BL/6, n=45). The level of IL-16 in sera and skin graft homogenates was tested by ELISA at 1, 3, 5 and 7 days after transplantation and the expression of IL-16 mRNA in skin allografts was measured by reverse transcription PCR at the same time points.
  
  
  RESULTS
  At 3, 5 and 7 days after skin transplantation, the levels of IL-16 protein and mRNA in the skin allografts and serum level of IL-16 in the allotransplantation group were significantly higher than those in the isotransplant group.
  
  
  CONCLUSIONS
  The expression of IL-16 is increased in the mouse skin allografts.
authors.affiliation: Department of Immunology, Jining Medical University, Jining 272067, China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Immunology, Jining Medical University, Jining 272067, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: First People's Hospital of Jining City, Jining 272000, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Qu
authors.affiliation: Department of Immunology, Jining Medical University, Jining 272067, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Dai
authors.affiliation: Department of Immunology, Jining Medical University, Jining 272067, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Immunology, Jining Medical University, Jining 272067, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Immunology, Jining Medical University, Jining 272067, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Immunology, Jining Medical University, Jining 272067, China.
authors.forename: Chuanping
authors.initials: C
authors.lastname: Si
mesh_terms: D064591:Allografts; D000818:Animals; D019410:Interleukin-16 / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012867:Skin / Q000276:immunology*; D016038:Skin Transplantation
chemical_list: D019410:Interleukin-16