title: Genes influence the amplitude and timing of brain hemodynamic responses.
abstract: In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.
authors.affiliation: Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia.
authors.forename: Zuyao Y
authors.initials: ZY
authors.lastname: Shan
authors.affiliation: Queensland Brain Institute, The University of QLD, Brisbane, QLD 4072, Australia.
authors.forename: Anna A E
authors.initials: AAE
authors.lastname: Vinkhuyzen
authors.affiliation: Imaging Genetics Center, Institute of Neuroimaging Informatics, Keck School of Medicine of University of Southern California, Marina del Rey, CA 90292, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
authors.affiliation: Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia.
authors.forename: Katie L
authors.initials: KL
authors.lastname: McMahon
authors.affiliation: Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
authors.forename: Gabriëlla A M
authors.initials: GAM
authors.lastname: Blokland
authors.affiliation: School of Psychology, The University of QLD, Brisbane, QLD 4072, Australia.
authors.forename: Greig I
authors.initials: GI
authors.lastname: de Zubicaray
authors.affiliation: The Mind Research Network, Department of Electrical and Computer Engineering, The University of New Mexico, Albuquerque, NM 87313, USA.
authors.forename: Vince
authors.initials: V
authors.lastname: Calhoun
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.affiliation: Queensland Brain Institute, The University of QLD, Brisbane, QLD 4072, Australia.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Visscher
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Wright
authors.affiliation: Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia. Electronic address: d.reutens@uq.edu.au.
authors.forename: David C
authors.initials: DC
authors.lastname: Reutens
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000235:genetics*; D004777:Environment; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D005838:Genotype; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009474:Neurons / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic; D055815:Young Adult
keywords: Hemodynamic response function (HRF); Heritability; Neurovascular coupling; Twin study