title: A prospective analysis of blood donation history and risk of non-Hodgkin lymphoma.
abstract: Blood donation may influence subsequent NHL development via temporary immune system alterations. To test the hypothesis that frequent blood donation is associated with an increased risk of NHL and its most common histologic subtypes, this study followed 36 576 men in the Health Professionals Follow-up Study (HPFS), who provided information on frequency of blood donation in the past 30 years in 1992. This study confirmed 544 incident cases of NHL through 2010. Cox proportional hazards regression was used to calculate hazards ratios (HR) and 95% CI for the risk of all NHL and major NHL histologic subtypes associated with number of blood donations. In this prospective study, there was no significant evidence of an association between blood donation frequency and incidence of NHL (age-adjusted HR = 1.26, 95% CI = 0.94-1.68, comparing > 20 donations vs 0 donations over 30 years, p for trend = 0.18) or of any major NHL subtypes.
authors.affiliation: a Hematology Branch , National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda , MD , USA .
authors.forename: Kazusa
authors.initials: K
authors.lastname: Ishii
authors.affiliation: b Channing Division of Network Medicine, Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , MA , USA .
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Birmann
authors.affiliation: b Channing Division of Network Medicine, Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , MA , USA .
authors.forename: Xuehong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: b Channing Division of Network Medicine, Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , MA , USA .|c Department of Epidemiology , and.|d Department of Nutrition , Harvard T.H. Chan School of Public Health , Boston , MA , USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Giovannucci
authors.affiliation: b Channing Division of Network Medicine, Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , MA , USA .|c Department of Epidemiology , and.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Bertrand
mesh_terms: D000328:Adult; D000368:Aged; D001782:Blood Donors; D015331:Cohort Studies; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D015994:Incidence; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000209:etiology* / Q000266:history; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011159:Population Surveillance; D012306:Risk
keywords: Blood donation; epidemiology; non-Hodgkin lymphoma; risk