title: Can MRI biomarkers at 3 T identify low-risk ductal carcinoma in situ?
abstract: OBJECTIVE
  The objective was to explore whether 3-T magnetic resonance imaging (MRI) can identify low-risk ductal carcinoma in situ (DCIS).
  
  
  METHODS
  Dynamic contrast-enhanced and diffusion-weighted (DWI) MRI features of 36 DCIS lesions [8 low risk, Van Nuys Pathologic Classification (VNPC) 1; 28 high risk, VNPC 2/3] were reviewed. An MRI model that best identified low-risk DCIS was determined using multivariate logistic regression.
  
  
  RESULTS
  Low-risk DCIS exhibited different DWI properties [i.e., higher contrast-to-noise ratio (P=.02) and lower normalized apparent diffusion coefficients (P=.04)] than high-risk DCIS. A model combining these DWI features provided best performance (area under receiver operating characteristic curve =0.86).
  
  
  CONCLUSIONS
  DWI may help identify DCIS lesions requiring less therapy.
authors.affiliation: University of Washington, Seattle Cancer Care Alliance, Department of Radiology, Breast Imaging Section, 825 Eastlake Avenue East, P.O. Box 19023, Seattle, WA 98109-1023, USA. Electronic address: hrahbar@uw.edu.
authors.forename: Habib
authors.initials: H
authors.lastname: Rahbar
authors.affiliation: University of Washington, Seattle Cancer Care Alliance, Department of Radiology, Breast Imaging Section, 825 Eastlake Avenue East, P.O. Box 19023, Seattle, WA 98109-1023, USA.
authors.forename: Sana
authors.initials: S
authors.lastname: Parsian
authors.affiliation: University of Washington, Seattle Cancer Care Alliance, Department of Radiology, Breast Imaging Section, 825 Eastlake Avenue East, P.O. Box 19023, Seattle, WA 98109-1023, USA.
authors.forename: Diana L
authors.initials: DL
authors.lastname: Lam
authors.affiliation: University of Washington, Seattle Cancer Care Alliance, Department of Radiology, Breast Imaging Section, 825 Eastlake Avenue East, P.O. Box 19023, Seattle, WA 98109-1023, USA.
authors.forename: Brian N
authors.initials: BN
authors.lastname: Dontchos
authors.affiliation: University of Washington Department of Anatomic Pathology, 1959 NE Pacific St., Box 357470, Seattle, WA 98195, USA.
authors.forename: Nicole K
authors.initials: NK
authors.lastname: Andeen
authors.affiliation: University of Washington Department of Anatomic Pathology, 1959 NE Pacific St., Box 357470, Seattle, WA 98195, USA.
authors.forename: Mara H
authors.initials: MH
authors.lastname: Rendi
authors.affiliation: University of Washington, Seattle Cancer Care Alliance, Department of Radiology, Breast Imaging Section, 825 Eastlake Avenue East, P.O. Box 19023, Seattle, WA 98109-1023, USA.
authors.forename: Constance D
authors.initials: CD
authors.lastname: Lehman
authors.affiliation: University of Washington, Seattle Cancer Care Alliance, Department of Radiology, Breast Imaging Section, 825 Eastlake Avenue East, P.O. Box 19023, Seattle, WA 98109-1023, USA.
authors.forename: Savannah C
authors.initials: SC
authors.lastname: Partridge
mesh_terms: D015415:Biomarkers; D001943:Breast Neoplasms / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007089:Image Enhancement; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D003287:Contrast Media
keywords: Biomarker; Diffusion-weighted imaging; Ductal carcinoma in situ; MRI