title: Single nucleotide polymorphism in the SEPS1 gene may contribute to the risk of various human diseases: a meta-analysis.
abstract: BACKGROUND
  Recently the G-105A promoter polymorphism in SEPS1 has been shown to increase pro-inflammatory cytokine expression and, thus, to be correlated with various types of human cancers and diseases.
  
  
  OBJECTIVE
  This study examined whether this functional polymorphism was related to the risks of several human diseases by performing a meta-analysis.
  
  
  METHODS
  This study identified all published studies in MEDLINE, Science Citation Index, the Cochrane Library, PubMed, Embase, Current Contents Index and three Chinese databases.
  
  
  CONCLUSIONS
  Eleven case-control studies were incorporated into this meta-analysis. The results showed that carriers of the rs28665122 G > A polymorphism in the SEPS1 gene are at increased risk of developing diseases under five genetic models. According to the ethnicity-stratified sub-group analysis, SEPS1 rs28665122 polymorphism is significantly linked to increased risk of developing related diseases in Europeans under five genetic models; but not among Asians. This data indicates a statistical association between SEPS1 rs28665122 G > A variants and the development of various human diseases. Such findings suggest that SEPS1 may be a potential gene marker for disease diagnosis and prognosis.
authors.affiliation: a Centers for Disease Control and Prevention of Laiwu City , Laiwu , PR China .
authors.forename: Hong-Yun
authors.initials: HY
authors.lastname: Sun
authors.affiliation: b Department of Food Nutrition and Student Health Division , Centers for Disease Control and Prevention of Laiwu City , Laiwu , PR China .
authors.forename: Tai-Bin
authors.initials: TB
authors.lastname: Liu
authors.affiliation: c Office of Centers for Disease Control and Prevention of Laiwu City , Laiwu , PR China , and.
authors.forename: Qing-Chang
authors.initials: QC
authors.lastname: Wang
authors.affiliation: c Office of Centers for Disease Control and Prevention of Laiwu City , Laiwu , PR China , and.
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Wu
authors.affiliation: d Immunization Management Division, Centers for Disease Control and Prevention of Laiwu City , Laiwu , PR China.
authors.forename: Yu-Jing
authors.initials: YJ
authors.lastname: He
mesh_terms: D000483:Alleles; D019992:Databases as Topic; D004194:Disease / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008957:Models, Genetic; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012044:Regression Analysis; D012307:Risk Factors; D051140:Selenoproteins / Q000235:genetics*
chemical_list: D008565:Membrane Proteins; C487710:SELENOS protein, human; D051140:Selenoproteins
keywords: Genetic polymorphism; SEPS1; human diseases; meta-analysis