title: Identification of an inflammatory bowel disease patient with a deep vein thrombosis and an altered clot lysis profile.
abstract: Patients with inflammatory bowel diseases (IBD), a chronic inflammatory disease characterized by flares and remission, are prone to develop thrombosis. The mechanism behind this prothrombotic state is not completely understood but is definitely multifactorial and linked with excessive inflammation observed in these patients. So far, no biomarker exists to select among IBD patients those with and increased risk for thrombosis. Corticosteroid therapy, given as rescue IBD treatment, is known to increase the thrombotic risk, whereas for antitumor necrosis factor (TNF)-alpha therapy such as infliximab, given to induce and maintain remission in IBD, the results are inconclusive. Here, we describe a 31-year-old IBD patient who developed a deep vein thrombosis. We determined the clot lysis profiles before and after developing thrombosis. We showed that a global functional clot lysis assay can be used as a tool to identify IBD patients who may benefit from thromboprophylactic therapy.
authors.affiliation: aLaboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven bTranslational Research in GastroIntestinal Disorders, Department of Gastroenterology, UZ Leuven, Belgium.
authors.forename: Lize
authors.initials: L
authors.lastname: Bollen
authors.forename: Joke
authors.initials: J
authors.lastname: Wuyts
authors.forename: Séverine
authors.initials: S
authors.lastname: Vermeire
authors.forename: Ann
authors.initials: A
authors.lastname: Gils
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000187:drug effects; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001379:Azathioprine / Q000009:adverse effects; D005260:Female; D063285:Fibrin Clot Lysis Time; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D000069285:Infliximab / Q000009:adverse effects*; D008775:Methylprednisolone / Q000009:adverse effects; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D000069285:Infliximab; C559198:etrolizumab; D001379:Azathioprine; D008775:Methylprednisolone