title: [The 444G/A and -1021 C/T polymorphisms of the dopamine-beta-hydroxylase gene modulate the trajectory of alcohol dependence development].
abstract: OBJECTIVE
  To study the influence of 444 G/A (rs 1108580) and -1021 C/T (rs 1611115) polymorphisms of the dopamine beta-hydroxylase (DBH) gene on clinical parameters of the trajectory of alcohol dependence.
  
  
  METHODS
  Authors studied 548 male inpatients, of Slavic ethnicity, with ICD-10 diagnosis of «alcohol dependence» (F-10.2).
  
  
  RESULTS
  The effects of DBH * 444 G/A on the rate of formation of alcohol withdrawal syndrome (AWS), and DBH *-1021C/T on the age of onset of alcohol abuse with significant role of the age of first alcohol use were identified. In 444 G/A GG carriers, the development of AWS was accelerated since the beginning of alcohol abuse compared with AA carriers (p=0.026), AG carriers occupied an intermediate position. In 22.5% of GG carriers, AWS developed within 2 years (AA: 8.11%, p=0.005; AG: 17.67%, p=0.04). According to the results of linear regression analysis, in AG carriers the alcohol abuse (p=0.037) and the AWS (p=0.049) developed earlier than in AA carriers if the first alcohol use occured at the age of about 15 years. Among -1021C/T genotype carriers who began to abuse alcohol at an early age (before 20 years), there were 23.45% patients with CC genotype and only 11.97% with a T allele (genotypes CT+TT) (p=0.03), but T carriers began to abuse alcohol earlier than others (p=0.05) if the first alcohol use occurred at the age of about 16 years.
  
  
  CONCLUSIONS
  The results can be used to search for genetic markers for prognosis of alcohol dependence development.
authors.affiliation: National Research Centre on Addictions, Ministry of Health of the Russian Federation, Moscow.
authors.forename: A O
authors.initials: AO
authors.lastname: Kibitov
authors.affiliation: National Research Centre on Addictions, Ministry of Health of the Russian Federation, Moscow.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Voskoboeva
authors.affiliation: National Research Centre on Addictions, Ministry of Health of the Russian Federation, Moscow.
authors.forename: N A
authors.initials: NA
authors.lastname: Chuprova
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology*; D000483:Alleles; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D000431:Ethanol / Q000009:adverse effects; D005819:Genetic Markers; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013375:Substance Withdrawal Syndrome / Q000235:genetics
chemical_list: D005819:Genetic Markers; D000431:Ethanol; D004299:Dopamine beta-Hydroxylase