title: Crack-free polydimethylsiloxane-bioactive glass-poly(ethylene glycol) hybrid monoliths with controlled biomineralization activity and mechanical property for bone tissue regeneration.
abstract: Crack-free organic-inorganic hybrid monoliths with controlled biomineralization activity and mechanical property have an important role for highly efficient bone tissue regeneration. Here, biomimetic and crack-free polydimethylsiloxane (PDMS)-modified bioactive glass (BG)-poly(ethylene glycol) (PEG) (PDMS-BG-PEG) hybrids monoliths were prepared by a facile sol-gel technique. Results indicate that under the assist of co-solvents, BG sol and PDMS and PEG could be hybridized at a molecular level, and effects of the PEG molecular weight on the structure, biomineralization activity, and mechanical property of the as-prepared hybrid monoliths were also investigated in detail. It is found that an addition of low molecular weight PEG can significantly prevent the formation of cracks and speed up the gelation of the hybrid monoliths, and the surface microstructure of the hybrid monoliths can be changed from the porous to the smooth as the PEG molecular weight increases. Additionally, the hybrid monoliths with low molecular weight PEG show the high formation of the biological apatite layer, while the hybrids with high molecular weight PEG exhibit negligible biomineralization ability in simulated body fluid (SBF). Furthermore, the PDMS-BG-PEG 600 hybrid monolith has significantly high compressive strength (32 ± 3 MPa) and modulus (153 ± 11 MPa), as well as good cell biocompatibility by supporting osteoblast (MC3T3-E1) attachment and proliferation. These results indicate that the as-prepared PDMS-BG-PEG hybrid monoliths may have promising applications for bone tissue regeneration.
authors.affiliation: Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education, International Center for Dielectric Research, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education, International Center for Dielectric Research, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Yuzhang
authors.initials: Y
authors.lastname: Du
authors.affiliation: Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education, International Center for Dielectric Research, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: wxque@mail.xjtu.edu.cn.
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Que
authors.affiliation: Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education, International Center for Dielectric Research, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Yonglei
authors.initials: Y
authors.lastname: Xing
authors.affiliation: National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Chen
authors.affiliation: Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education, International Center for Dielectric Research, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China; State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710054, China; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China. Electronic address: rayboo@xjtu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Lei
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001861:Bone Regeneration; D002113:Calcification, Physiologic; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D005898:Glass; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D004129:Dimethylpolysiloxanes; D011092:Polyethylene Glycols; C013830:baysilon
keywords: Bioactive glass; Biomineralization activity; Hybrid structure; Poly(ethylene glycol); Polydimethylsiloxane; Sol–gel process