title: Study of Ki67 and CD10 expression as predictive factors of recurrence of ameloblastoma.
abstract: BACKGROUND
  Ameloblastoma is a rare, benign, purely epithelial odontogenic tumour, characterized by a high potential for local invasion and recurrence.
  
  
  OBJECTIVE
  To study the epidemiological and histological characteristics of ameloblastoma. To study Ki67 and CD10 immunostaining in ameloblastoma and to investigate a possible correlation between these two markers and recurrence of this tumour.
  
  
  METHODS
  An immunohistochemical study using Ki67 and CD10 monoclonal antibodies was performed on 37 paraffin blocks obtained from the Charles-Nicolle hospital pathology department in Tunis over a 9-year period (2004-2012). Statistical analysis was performed with Statistical Package for Social Sciences (SPSS) software version 15.1.
  
  
  RESULTS
  This series of 37 cases comprised 21 males and 16 females (sex ratio: 1.3) with a mean age of 39 years (range: 7 to 70 years), corresponding to 36 cases of intraosseous ameloblastoma and one case of gingival ameloblastoma. Thirty-two cases were polycystic and 5 cases were unicystic. Eighteen cases of local recurrence were observed. No correlation was demonstrated between recurrence and the various clinical and histological parameters and treatment modalities. However, a significant correlation was demonstrated between recurrence and Ki67 and CD10 expression (P=0.000 and 0.002, respectively).
  
  
  CONCLUSIONS
  The Ki67 proliferation index and stromal CD10 expression can be considered to be predictive factors of ameloblastoma recurrence.
authors.affiliation: Service de cytologie et d'anatomie pathologique, hôpital Charles-Nicolle, Tunis, Tunisia.
authors.forename: B
authors.initials: B
authors.lastname: Ahlem
authors.affiliation: Service de cytologie et d'anatomie pathologique, hôpital Charles-Nicolle, Tunis, Tunisia. Electronic address: wided.ajjouligh@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Wided
authors.affiliation: Service de chirurgie maxillo-faciale, hôpital Charles-Nicolle, Tunis, Tunisia.
authors.forename: L
authors.initials: L
authors.lastname: Amani
authors.affiliation: Service de cytologie et d'anatomie pathologique, hôpital Charles-Nicolle, Tunis, Tunisia.
authors.forename: Z
authors.initials: Z
authors.lastname: Nadia
authors.affiliation: Service de cytologie et d'anatomie pathologique, hôpital Charles-Nicolle, Tunis, Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Amira
authors.affiliation: Service de cytologie et d'anatomie pathologique, hôpital Charles-Nicolle, Tunis, Tunisia.
authors.forename: F
authors.initials: F
authors.lastname: Faten
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000564:Ameloblastoma / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D015260:Neprilysin / Q000378:metabolism*; D012189:Retrospective Studies; D017154:Stromal Cells / Q000378:metabolism; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D015260:Neprilysin
keywords: Ameloblastoma; CD10; Immunohistochemistry; Ki67; Recurrence