title: Multi-laboratory inter-institute reproducibility study of IVOCT and IVUS assessments using published consensus document definitions.
abstract: OBJECTIVE
  The aim of this study was to investigate the reproducibility of intravascular optical coherence tomography (IVOCT) assessments, including a comparison to intravascular ultrasound (IVUS). Intra-observer and inter-observer variabilities of IVOCT have been previously described, whereas inter-institute reliability in multiple laboratories has never been systematically studied.
  
  
  RESULTS
  In 2 independent laboratories with intravascular imaging expertise, 100 randomized matched data sets of IVOCT and IVUS images were analysed by 4 independent observers according to published consensus document definitions. Intra-observer, inter-observer, and inter-institute variabilities of IVOCT qualitative and quantitative measurements vs. IVUS measurements were assessed. Minor inter- and intra-observer variability of both imaging techniques was observed for detailed qualitative and geometric analysis, except for inter-observer mixed plaque identification on IVUS (κ = 0.70) and for inter-observer fibrous cap thickness measurement reproducibility on IVOCT (ICC = 0.48). The magnitude of inter-institute measurement differences for IVOCT was statistically significantly less than that for IVUS concerning lumen cross-sectional area (CSA), maximum and minimum lumen diameters, stent CSA, and maximum and minimum stent diameters (P < 0.001, P < 0.001, P < 0.001, P = 0.02, P < 0.001, and P = 0.01, respectively). Minor inter-institute measurement variabilities using both techniques were also found for plaque identification.
  
  
  CONCLUSIONS
  In the measurement of lumen CSA, maximum and minimum lumen diameters, stent CSA, and maximum and minimum stent diameters by analysts from two different laboratories, reproducibility of IVOCT was more consistent than that of IVUS.
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, BHX604A, Boston, MA 02114, USA.
authors.forename: Edouard
authors.initials: E
authors.lastname: Gerbaud
authors.affiliation: Columbia University Medical Center, New York, NY, USA Cardiovascular Research Foundation, New York, NY, USA.
authors.forename: Giora
authors.initials: G
authors.lastname: Weisz
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, BHX604A, Boston, MA 02114, USA.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, BHX604A, Boston, MA 02114, USA.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kashiwagi
authors.affiliation: Columbia University Medical Center, New York, NY, USA Cardiovascular Research Foundation, New York, NY, USA.
authors.forename: Takehisa
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Columbia University Medical Center, New York, NY, USA Cardiovascular Research Foundation, New York, NY, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Columbia University Medical Center, New York, NY, USA Cardiovascular Research Foundation, New York, NY, USA.
authors.forename: Christiano
authors.initials: C
authors.lastname: Souza
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, BHX604A, Boston, MA 02114, USA.
authors.forename: Brett E
authors.initials: BE
authors.lastname: Bouma
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, BHX604A, Boston, MA 02114, USA.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Suter
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, BHX604A, Boston, MA 02114, USA.
authors.forename: Milen
authors.initials: M
authors.lastname: Shishkov
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, BHX604A, Boston, MA 02114, USA.
authors.forename: Giovanni J
authors.initials: GJ
authors.lastname: Ughi
authors.affiliation: Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Elkan F
authors.initials: EF
authors.lastname: Halpern
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, BHX604A, Boston, MA 02114, USA.
authors.forename: Mireille
authors.initials: M
authors.lastname: Rosenberg
authors.affiliation: Department of Cardiology, Lahey Clinic Medical Center, Burlington, MA, USA.
authors.forename: Sergio
authors.initials: S
authors.lastname: Waxman
authors.affiliation: Columbia University Medical Center, New York, NY, USA Cardiovascular Research Foundation, New York, NY, USA.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Moses
authors.affiliation: Columbia University Medical Center, New York, NY, USA Cardiovascular Research Foundation, New York, NY, USA.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.affiliation: Columbia University Medical Center, New York, NY, USA Cardiovascular Research Foundation, New York, NY, USA.
authors.forename: Akiko
authors.initials: A
authors.lastname: Maehara
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, BHX604A, Boston, MA 02114, USA Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA gtearney@partners.org.
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Tearney
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D015906:Angioplasty, Balloon, Coronary / Q000379:methods / Q000401:mortality; D006328:Cardiac Catheterization / Q000379:methods; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy; D017558:Elective Surgical Procedures / Q000379:methods; D015588:Observer Variation; D015203:Reproducibility of Results; D015607:Stents; D015996:Survival Rate; D041623:Tomography, Optical Coherence / Q000379:methods; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods; D014654:Vascular Patency / Q000502:physiology; D003245:Consensus Statements as Topic
keywords: Intravascular ultrasound imaging; Optical coherence tomography; Optical frequency domain imaging; Reproducibility