title: Changes in plasma thrombospondin-1 concentrations following acute intracerebral hemorrhage.
abstract: BACKGROUND
  Angiogenesis is a fundamental process for brain development and repair. Thrombospondin-1 is the first identified endogenous angiogenesis inhibitor. Its expression in rat brain is upregulated after intracerebral hemorrhage (ICH). We determined whether plasma thrombospondin-1 concentrations are associated with injury severity and prognosis in ICH patients.
  
  
  METHODS
  This observational, prospective study recruited 110 patients and 110 age- and gender-matched healthy controls. Blood samples were collected from the patients at admission and from the healthy controls at study entry to measure plasma thrombospondin-1 concentrations. The endpoints included 1-week mortality, 6-month mortality, 6-month overall survival and 6-month unfavorable outcome (modified Rankin Scale score >2).
  
  
  RESULTS
  Plasma thrombospondin-1 concentrations were markedly higher in patients than in healthy controls. Thrombospondin-1 was an independent predictive factor for all endpoints and plasma thrombospondin-1 concentrations were highly associated with injury severity reflected by hematoma volume and National Institutes of Health Stroke Scale score. Under receiver operating characteristic curves, plasma thrombospondin-1 concentrations had similar predictive values compared with hematoma volume and National Institutes of Health Stroke Scale score.
  
  
  CONCLUSIONS
  Increased plasma thrombospondin-1 concentrations following ICH are independently associated with injury severity and short-term and long-term clinical outcomes.
authors.affiliation: Department of Neurosurgery, Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, PR China.
authors.forename: Xiao-Qiao
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, PR China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Hangzhou First People's Hospital, Nanjing Medical University Affiliated Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, PR China. Electronic address: hzqiangzhu@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, Jinhua People's Hospital, 228 Xinhua Street, Jinhua 321000, PR China.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Cheng
authors.affiliation: Department of Neurosurgery, Jinhua People's Hospital, 228 Xinhua Street, Jinhua 321000, PR China.
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Central Hospital of Jinhua City, 351 Mingyue Street, Jinhua 321000, PR China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Lin
authors.affiliation: Department of clinical laboratory, Jinhua People's Hospital, 228 Xinhua Street, Jinhua 321000, PR China.
authors.forename: Xian-Lin
authors.initials: XL
authors.lastname: Ten
authors.affiliation: Department of Emergency Medicine, Jinhua People's Hospital, 228 Xinhua Street, Jinhua 321000, PR China.
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Tang
authors.affiliation: Department of Neurology, Jinhua People's Hospital, 228 Xinhua Street, Jinhua 321000, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis; D019700:Thrombospondin 1 / Q000097:blood*
chemical_list: D019700:Thrombospondin 1
keywords: Biomarker; Intracerebral hemorrhage; Prognosis; Severity; Thrombospondin-1