title: Regulation of cytokinesis by membrane trafficking involving small GTPases and the ESCRT machinery.
abstract: During cell division, cells undergo membrane remodeling to achieve changes in their size and shape. In addition, cell division entails local delivery and retrieval of membranes and specific proteins as well as remodeling of cytoskeletons, in particular, upon cytokinetic abscission. Accumulating lines of evidence highlight that endocytic membrane removal from and subsequent membrane delivery to the plasma membrane are crucial for the changes in cell size and shape, and that trafficking of vesicles carrying specific proteins to the abscission site participate in local remodeling of membranes and cytoskeletons. Furthermore, the endosomal sorting complex required for transport (ESCRT) machinery has been shown to play crucial roles in cytokinetic abscission. Here, the author briefly overviews membrane-trafficking events early in cell division, and subsequently focus on regulation and functional significance of membrane trafficking involving Rab11 and Arf6 small GTPases in late cytokinesis phases and assembly of the ESCRT machinery in cytokinetic abscission.
authors.affiliation: a Graduate School of Pharmaceutical Sciences, Kyoto University , Kyoto , Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Nakayama
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D048749:Cytokinesis; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D020558:GTP Phosphohydrolases
keywords: Arf; ESCRT; Rab; cytokinesis; membrane traffic; small GTPase