title: Therapeutic uses of FGFs.
abstract: Fibroblast growth factors and their receptors regulate a wide range of biological functions from developmental processes during embryogenesis to diverse physiological roles in the adult state, including the regulation of angiogenesis, wound healing, and metabolism. Genetic defects, or dysregulated FGF signaling, result in a variety of human conditions, which in turn provides a myriad of potential opportunities for FGF-targeted therapies to treat diseases such as cancer, impaired wound healing, metabolic syndrome, chronic kidney disease, and cardiovascular diseases. This review summarizes some of these approaches, focusing on recombinant FGFs or FGFR fragments, small molecule inhibitors, agonistic and antagonistic antibodies, and nucleic acid based therapeutics.
authors.affiliation: Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, United States.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, United States. Electronic address: yangl@amgen.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D005346:Fibroblast Growth Factors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D012038:Regeneration / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects
chemical_list: D005346:Fibroblast Growth Factors
keywords: Antibody; FGF; FGFR; Kinase inhibitor; Klotho; Therapy