title: Role of sebaceous glands in inflammatory dermatoses.
abstract: Skin is an important interface between the host and its environment. Inflammatory dermatoses often have disrupted skin barrier function, rendering patients more susceptible to allergenic triggers leading to an exaggerated immune response. The skin surface lipid film, an important component of the skin barrier, comprises a mixture of keratinocyte and sebaceous gland-derived lipids. Recent evidence demonstrated that defective keratinocyte lipid synthesis predisposes for the development of atopic dermatitis. However, the important role of sebaceous gland-derived lipids in skin inflammatory diseases may be underrecognized. This overview focuses on the importance of the contribution of sebaceous glands to barrier function. Sebaceous gland alteration may play a role in the pathogenesis of common skin diseases including acne vulgaris, atopic dermatitis, psoriasis, rosacea, and seborrheic dermatitis.
authors.affiliation: Department of Dermatology, University of California, Davis, California.
authors.forename: Vivian Y
authors.initials: VY
authors.lastname: Shi
authors.affiliation: School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
authors.forename: Michael
authors.initials: M
authors.lastname: Leo
authors.affiliation: School of Medicine, University of California, Davis, California.
authors.forename: Lauren
authors.initials: L
authors.lastname: Hassoun
authors.affiliation: David Geffen School of Medicine, University of California, Los Angeles, California.
authors.forename: Dev S
authors.initials: DS
authors.lastname: Chahal
authors.affiliation: Department of Dermatology, University of California, San Francisco, California.
authors.forename: Howard I
authors.initials: HI
authors.lastname: Maibach
authors.affiliation: Department of Dermatology, University of California, Davis, California. Electronic address: rksivamani@ucdavis.edu.
authors.forename: Raja K
authors.initials: RK
authors.lastname: Sivamani
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000209:etiology*; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000473:pathology; D012628:Dermatitis, Seborrheic / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D008055:Lipids / Q000032:analysis*; D011565:Psoriasis / Q000209:etiology; D012393:Rosacea / Q000209:etiology; D012627:Sebaceous Glands / Q000378:metabolism* / Q000473:pathology; D012629:Sebum / Q000737:chemistry* / Q000378:metabolism; D012879:Skin Physiological Phenomena
chemical_list: D008055:Lipids
keywords: acne; atopic dermatitis; eczema; psoriasis; rosacea; sebocytes; seborrheic dermatitis; sebum