title: Advagraf(®) , a once-daily prolonged release tacrolimus formulation, in kidney transplantation: literature review and guidelines from a panel of experts.
abstract: The efficacy and safety of tacrolimus twice-a-day (BID) and once-a-day (QD) formulations are similar. However, the available information regarding the initiation and management of tacrolimus QD is sparse and practical information is lacking. A panel of French experts extensively reviewed the available literature on tacrolimus pharmacokinetics, clinical efficacy, and safety in kidney transplantation and, based on their own day-to-day experience, provided the practitioners with practical guidelines for the daily use and management of tacrolimus QD in de novo initiation or early conversion.
authors.affiliation: Nephrology and Transplant Department, Strasbourg University Hospital, Strasbourg, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Caillard
authors.affiliation: Nephrology and Transplant Department, Strasbourg University Hospital, Strasbourg, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Moulin
authors.affiliation: Transplant, Nephrology and Immunology Department, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Buron
authors.affiliation: Nephrology, Dialysis and Renal Transplants Department, North Hospital, Saint Etienne University Hospital, Saint Priest en Jarez, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Mariat
authors.affiliation: Nephrology and Transplant Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Assistance Publique Hôpitaux de Paris, Henri-Mondor Hospital, Créteil, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Audard
authors.affiliation: Nephrology and Transplant Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Assistance Publique Hôpitaux de Paris, Henri-Mondor Hospital, Créteil, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Grimbert
authors.affiliation: CHU Limoges, UMR 850 INSERM, University of Limoges, Limoges, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Marquet
mesh_terms: D001499:Bayes Theorem; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D016903:Drug Monitoring; D019317:Evidence-Based Medicine; D005602:France; D006084:Graft Rejection; D064368:Healthy Volunteers; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016030:Kidney Transplantation; D016559:Tacrolimus / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D003692:Delayed-Action Preparations; D007166:Immunosuppressive Agents; D016559:Tacrolimus
keywords: clinical practice; extended release tacrolimus; immunosuppression; kidney transplant; therapeutic drug monitoring