title: Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage.
abstract: The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag.
authors.affiliation: Instituto de Biología Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina.
authors.forename: Micol
authors.initials: M
authors.lastname: Tomaiuolo
authors.affiliation: Instituto de Biología Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Katche
authors.affiliation: Instituto de Biología Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina ; Departamento de Fisiología, Biología Molecular y Celular Dr. Hector Maldonado, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina.
authors.forename: Haydee
authors.initials: H
authors.lastname: Viola
authors.affiliation: Instituto de Biología Celular y Neurociencias "Dr. Eduardo De Robertis", Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina ; Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina.
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Medina
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D003598:Cytoskeletal Proteins / Q000096:biosynthesis; D004777:Environment; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D057567:Memory, Long-Term / Q000502:physiology*; D009043:Motor Activity; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000502:physiology; D050641:Receptors, Dopamine D5 / Q000502:physiology; D021641:Recognition, Psychology
chemical_list: D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D017447:Receptors, Dopamine D1; C092069:activity regulated cytoskeletal-associated protein; D050641:Receptors, Dopamine D5