title: Development and evaluation of a non-peptidic ligand for the molecular imaging of inflammatory processes using S100A9 (MRP14) as a novel target.
abstract: The establishment of novel molecular imaging tools to monitor the local activity of inflammation remains an interdisciplinary challenge. Our target, the alarmin S100A9, one subunit of the heterodimer S100A8/S100A9 (calprotectin), is locally secreted in high concentrations from immigrated and activated phagocytes at local sites of inflammation. Calprotectin is already a well established serum biomarker for many inflammatory disorders. Here we show the development and first evaluation of the novel S100A9 specific molecular imaging probe for optical imaging of local inflammatory activity in vivo.
authors.affiliation: European Institute for Molecular Imaging (EIMI), University of Münster, Waldeyerstr. 15, 48149 Münster, Germany. faustan@uni-muenster.de.
authors.forename: A
authors.initials: A
authors.lastname: Faust
authors.forename: T
authors.initials: T
authors.lastname: Völler
authors.forename: F
authors.initials: F
authors.lastname: Busch
authors.forename: M
authors.initials: M
authors.lastname: Schäfers
authors.forename: J
authors.initials: J
authors.lastname: Roth
authors.forename: S
authors.initials: S
authors.lastname: Hermann
authors.forename: T
authors.initials: T
authors.lastname: Vogl
mesh_terms: D040502:Calgranulin B / Q000378:metabolism*; D002232:Carbocyanines; D005456:Fluorescent Dyes; D007249:Inflammation / Q000378:metabolism; D008024:Ligands; D057054:Molecular Imaging
chemical_list: C098793:CY5.5 cyanine dye; D040502:Calgranulin B; D002232:Carbocyanines; D005456:Fluorescent Dyes; D008024:Ligands