title: What Constitutes an "Adequate" Trial in Migraine Prevention?
abstract: Comprehensively assessing the quality of prior preventive treatment attempts often reveals modifiable variables that may account for treatment failure. Similarly, a comprehensive and systematic approach when planning a preventive medication trial is critical for optimizing the chances of treatment success. In this review, we summarize the key elements to be included when assessing the adequacy of a preventive treatment trial. We have developed and included checklists that can be used by providers to improve their assessments of prior preventive treatment trials and to assist with planning a high-quality treatment trial with a new migraine preventive medication.
authors.affiliation: Department of Neurology, University of Kentucky, 740 S. Limestone, L445, Lexington, KY, 40536, USA. jonathan.smith@uky.edu.
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Smith
authors.affiliation: Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Schwedt
mesh_terms: D002986:Clinical Trials as Topic; D003951:Diagnostic Errors / Q000517:prevention & control*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000517:prevention & control*; D010819:Physician's Role; D011788:Quality of Life; D016896:Treatment Outcome
keywords: Clinical trial; Migraine; Outcome; Prevention; Quality