title: The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin.
abstract: We report an ATP-dependent ubiquitin conjugation with IDE which, in turn, promotes Ub-Ub linkages in tube tests. We propose a novel function for IDE as a non-canonical ubiquitin activating enzyme.
authors.affiliation: Dipartimento di Scienze Chimiche, Università degli Studi di Catania, V.le A. Doria 6, 95125 Catania, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Grasso
authors.forename: V
authors.initials: V
authors.lastname: Lanza
authors.forename: G
authors.initials: G
authors.lastname: Malgieri
authors.forename: R
authors.initials: R
authors.lastname: Fattorusso
authors.forename: A
authors.initials: A
authors.lastname: Pietropaolo
authors.forename: E
authors.initials: E
authors.lastname: Rizzarelli
authors.forename: D
authors.initials: D
authors.lastname: Milardi
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D007339:Insulysin / Q000737:chemistry*; D025801:Ubiquitin / Q000737:chemistry*; D054875:Ubiquitination; D014452:Ubiquitins / Q000737:chemistry*
chemical_list: C109184:UBD protein, human; D025801:Ubiquitin; D014452:Ubiquitins; D000255:Adenosine Triphosphate; D007339:Insulysin