title: Prolonged Complete Response in a Pediatric Patient With Primary Peripheral T-Cell Lymphoma of the Central Nervous System.
abstract: We describe a child with a 2-week history of progressive headaches, blurry vision, and intermittent vomiting. Magnetic resonance imaging (MRI) of the brain showed a deep left hemispheric lesion with extension into the corpus callosum. Histology and immunophenotyping of the lesion was consistent with peripheral T-cell lymphoma, not otherwise specified. Chemotherapy was initiated and a complete remission was achieved. This case illustrates that a chemotherapeutic regimen used in adults with central nervous system (CNS) lymphoma can achieve durable remissions in pediatric patients with peripheral T-cell lymphoma, not otherwise specified of the CNS.
authors.affiliation: a Division of Pediatric Hematology and Oncology, Center for Cancer and Blood Disorders , Children's National Medical Center , Washington, DC , USA.
authors.forename: Haneen
authors.initials: H
authors.lastname: Shalabi
authors.affiliation: a Division of Pediatric Hematology and Oncology, Center for Cancer and Blood Disorders , Children's National Medical Center , Washington, DC , USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Angiolillo
authors.affiliation: b Department of Radiology, Children's National Medical Center , Washington, DC , USA.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Vezina
authors.affiliation: c Division of Hematology and Oncology , University of California, San Francisco , California , USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Rubenstein
authors.affiliation: d Laboratory of Pathology , National Institutes of Health , Bethesda , Maryland , USA.
authors.forename: Stefania
authors.initials: S
authors.lastname: Pittaluga
authors.affiliation: d Laboratory of Pathology , National Institutes of Health , Bethesda , Maryland , USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Raffeld
authors.affiliation: e Food and Drug Administration , Silver Spring , Maryland , USA.
authors.forename: Leigh
authors.initials: L
authors.lastname: Marcus
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D002648:Child; D003337:Corpus Callosum / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D011859:Radiography; D012074:Remission Induction
keywords: CNS tumors; NHL; therapy