title: The timing of deep brain stimulation for Parkinson disease in the UK from 1997 to 2012.
abstract: OBJECTIVE
  Deep brain stimulation (DBS) for Parkinson disease (PD) has traditionally been reserved for the late stages of the disease. There is evidence that DBS is also effective if applied earlier in the disease course. Changes in the frequency of DBS procedures in the UK over a 15-year period were investigated.
  
  
  METHODS
  A retrospective review was performed of patient age and disease duration for DBS surgery for PD in UK neurosurgical units from 1997 to 2012 using departmental databases.
  
  
  RESULTS
  The number of DBS procedures in the UK increased from three in 1997 to over 80 per year during this period. The mean age at the time of surgery (60 years) and the mean duration of PD at the time of DBS (11 years) remained unchanged over 15 years.
  
  
  CONCLUSIONS
  The age and disease duration at which DBS is performed for PD in the UK has been static over a 15-year period and DBS appears to remain a therapy for PD applied late in its course. This may change in the light of clinical evidence suggesting a benefit for earlier DBS.
authors.affiliation: Department of Neurosurgery, Kings College Hospital, London, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: deSouza
authors.affiliation: Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.|Department of Clinical Neurosciences, UCL Institute of Neurology, London, UK.
authors.forename: H
authors.initials: H
authors.lastname: Akram
authors.affiliation: Department of Neurosurgery, Queens Hospital Romford, Essex, UK.
authors.forename: H L
authors.initials: HL
authors.lastname: Low
authors.affiliation: Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Green
authors.affiliation: Department of Neurosurgery, Kings College Hospital, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Ashkan
authors.affiliation: Department of Clinical Neurosciences, UCL Institute of Neurology, London, UK.
authors.forename: A H V
authors.initials: AH
authors.lastname: Schapira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D046690:Deep Brain Stimulation / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D012189:Retrospective Studies; D013997:Time Factors; D006113:United Kingdom
keywords: Parkinson's disease; deep brain stimulation; timing