title: [Anti-inflammatory drugs and community-acquired pneumonia].
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in ambulatory medicine for their analgesic and antipyretic properties and are often used as self-medication. Their use in community-acquired pneumonia is associated with an increased risk of loco-regional complications, especially pleural empyema. Appropriate therapeutic care and hospital admissions are often delayed because of initial improvement of symptoms with NSAIDs. Despite worrying observational data, a causal link remains to be established. Currently, there is no recommendation cautioning against the use of NSAIDs in the management of community-acquired pneumonia.
authors.affiliation: Service de pneumologie, l'institut du thorax, hôpital G.-et-R.-Laënnec, CHU de Nantes, boulevard J.-Monod, 44093 Nantes cedex 1, France. Electronic address: stephanie.dirou@chu-nantes.fr.
authors.forename: S
authors.initials: S
authors.lastname: Dirou
authors.affiliation: Service de réanimation médicale et infectieuse, hôpital Bichat-Claude-Bernard, Assistance publique-hôpitaux de Paris, 75018 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Voiriot
mesh_terms: D000328:Adult; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D058633:Antipyretics / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D017714:Community-Acquired Infections / Q000150:complications*; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D016724:Empyema, Pleural / Q000139:chemically induced* / Q000209:etiology; D005334:Fever / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects; D018410:Pneumonia, Bacterial / Q000150:complications*; D017410:Practice Guidelines as Topic; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012306:Risk; D012651:Self Medication
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D058633:Antipyretics; D052246:Cyclooxygenase 2 Inhibitors
keywords: Anti-inflammatoires; Anti-inflammatory; Pleural empyema; Pleurésie purulente; Pneumonia; Pneumonie