title: Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.
abstract: Acetaminophen hepatotoxicity is characterized by extensive necrotic cell death and a sterile inflammatory response. A recent report suggested that a therapeutic intervention with chlorogenic acid, a dietary polyphenolic compound, protects against acetaminophen-induced liver injury by inhibiting the inflammatory injury. The purpose of this letter is to discuss a number of reasons why the protective mechanism of chlorogenic acid against acetaminophen hepatotoxicity does not involve an anti-inflammatory effect and provides an alternative explanation for the observed protection.
authors.affiliation: Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., MS 1018, Kansas City, KS 66160, USA. Electronic address: hjaeschke@kumc.edu.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Jaeschke
mesh_terms: D000082:Acetaminophen / Q000276:immunology / Q000633:toxicity*; D000410:Alanine Transaminase; D018712:Analgesics, Non-Narcotic / Q000276:immunology / Q000633:toxicity*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D017209:Apoptosis; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000188:drug therapy* / Q000276:immunology*; D002726:Chlorogenic Acid / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D008099:Liver / Q000187:drug effects* / Q000276:immunology; D020011:Protective Agents / Q000627:therapeutic use*
chemical_list: D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D020011:Protective Agents; D002726:Chlorogenic Acid; D000082:Acetaminophen; D000410:Alanine Transaminase
keywords: Acetaminophen hepatotoxicity; Natural products; Neutrophils; Sterile inflammation