title: Analysis of corneal topography in patients with pure microphthalmia in Eastern China.
abstract: OBJECTIVE
  To determine the typical corneal changes in pure microphthalmia using a corneal topography system and identify characteristics that may assist in early diagnosis.
  
  
  METHODS
  Patients with pure microphthalmia and healthy control subjects underwent corneal topography analysis (Orbscan IIZ® Corneal Topography System; Bausch and Lomb, Bridgewater, NJ, USA) to determine degree of corneal astigmatism (mean A), simulation of corneal astigmatism (sim A), mean keratometry (mean K), simulated keratometry (sim K), irregularities in the 3 - and 5-mm zone, and mean thickness of nine distinct corneal regions.
  
  
  RESULTS
  Patients with pure microphthalmia (n = 12) had significantly higher mean K, sim K, mean A, sim A, 3.0 mm irregularity and 5.0 mm irregularity, and exhibited significantly more false keratoconus than controls (n = 12). There was a significant between-group difference in the morphology of the anterior corneal surface and the central curvature of the cornea.
  
  
  CONCLUSIONS
  Changes in corneal morphology observed in this study could be useful in borderline situations to confirm the diagnosis of pure microphthalmia.
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Hu
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Gui-Ping
authors.initials: GP
authors.lastname: Gao
authors.affiliation: Department of Endocrinology and Metabolism, Third Hospital of Nanchang City, Nanchang, Jiangxi Province, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Chong-Gang
authors.initials: CG
authors.lastname: Pei
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China Freebee99@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shao
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002681:China; D063171:Corneal Pachymetry; D019781:Corneal Topography; D005260:Female; D006801:Humans; D008297:Male; D008850:Microphthalmos / Q000473:pathology*; D055815:Young Adult
keywords: Orbscan IIZ®; Pure microphthalmia; anthropometry; cornea thickness; corneal topography; keratoconus; morphology