title: Ginsenoside Rd Improves Learning and Memory Ability in APP Transgenic Mice.
abstract: Alzheimer's disease (AD) is a complicated neurodegenerative disease which causes memory loss and dementia. Many researchers have revealed the vital roles of β-amyloid proteins (Aβ) in the proceeds of AD. Aβ deposition in AD patients' brains might function as immune stimulus, and inflammation is believed to play an important role in AD pathologically. We experimentally used amyloid β-protein precursor (APP) transgenic (Tg) mice in this study to further clarify the neuroprotective effects of ginsenoside Rd on AD and its possible mechanisms. It was found that Rd could improve learning and memory ability in APP Tg mice, probably through inhibiting the transcription activity of NFκB. With the activation of the NFκB pathway being suppressed, the reduction of pro-inflammatory cytokines and the generation of protective factors had been increased ultimately. In conclusion, Rd had a neuroprotective effect on APP Tg mice, and it can be used as an alternative drug therapy in AD patients for their memory dysfunction.
authors.affiliation: Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.|Department of Clinical Aerospace Medicine, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Juanfang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Geriatrics, Shaanxi Provincial TCM Hospital, Xi'an, 710003, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Second Medical School of Southern Medical University, Guangzhou, 510515, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Linfu
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Shaanxi Provincial TCM Hospital, Xi'an, 710003, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. zhaogang@fmmu.edu.cn.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D036145:Ginsenosides / Q000627:therapeutic use*; D008568:Memory; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D018696:Neuroprotective Agents / Q000627:therapeutic use*
chemical_list: D016564:Amyloid beta-Protein Precursor; D016207:Cytokines; D036145:Ginsenosides; D016328:NF-kappa B; D018696:Neuroprotective Agents; C049863:ginsenoside Rd
keywords: APP transgenic mice; Alzheimer’s disease; Ginsenoside Rd; Inflammatory reaction