title: Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1.
abstract: Adult T-cell leukemia/lymphoma (ATLL), a T-cell neoplasm caused by human T-cell lymphotropic virus type 1 (HTLV-1), develops in the majority of cases in individuals who were infected with HTLV-1 as young children, by their mother during prolonged breastfeeding. We report the case of a Caucasian French man, whose parents were HTLV-1-seronegative and who developed ATLL after HTLV-1 sexual transmission by a Cameroonian woman. This hypothesis was corroborated by genotyping of the patient's virus, which revealed an HTLV-1B strain, found only in Central Africa, especially in Cameroon. Thus, ATLL may develop after HTLV-1 infection during adulthood, outside breastfeeding.
authors.affiliation: Hématologie Adulte , Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris ; Institut National de la Santé et de la Recherche Médicale (INSERM) U1163 and Centre National de la Recherche Scientifique (CNRS) ERL 8254 Bases Cellulaires et Moléculaires des Désordres Hématologiques ; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité
authors.forename: David
authors.initials: D
authors.lastname: Sibon
authors.affiliation: Département de Virologie , Institut Pasteur, Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes ; CNRS UMR 3569, Institut Pasteur.
authors.forename: Olivier
authors.initials: O
authors.lastname: Cassar
authors.affiliation: Département de Pathologie , Hôpital Purpan , Toulouse.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Duga
authors.affiliation: Laboratoire d'Hématologie , Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris.
authors.forename: Chantal
authors.initials: C
authors.lastname: Brouzes
authors.affiliation: Hématologie , Institut Gustave-Roussy , Villejuif.
authors.forename: David
authors.initials: D
authors.lastname: Ghez
authors.affiliation: Laboratoire de Virologie , Hôpital Purpan , Toulouse.
authors.forename: Christophe
authors.initials: C
authors.lastname: Pasquier
authors.affiliation: Département de Dermatologie , Hôpital Ambroise-Paré , Boulogne-Billancourt.
authors.forename: Claire
authors.initials: C
authors.lastname: Sibon
authors.affiliation: Département de Virologie , Institut Pasteur, Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes ; CNRS UMR 3569, Institut Pasteur.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Desrames
authors.affiliation: Laboratoire d'Oncovirologie et Biothérapies , CNRS UMR 5239, Centre Hospitalier Lyon Sud , France.
authors.forename: Franck
authors.initials: F
authors.lastname: Mortreux
authors.affiliation: Laboratoire d'Oncovirologie et Biothérapies , CNRS UMR 5239, Centre Hospitalier Lyon Sud , France.
authors.forename: Eric
authors.initials: E
authors.lastname: Wattel
authors.affiliation: Department of Internal Medicine , American University of Beirut , Lebanon.
authors.forename: Ali
authors.initials: A
authors.lastname: Bazarbachi
authors.affiliation: Département de Virologie , Institut Pasteur, Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes ; CNRS UMR 3569, Institut Pasteur.
authors.forename: Antoine
authors.initials: A
authors.lastname: Gessain
authors.affiliation: Hématologie Adulte , Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris ; Institut National de la Santé et de la Recherche Médicale (INSERM) U1163 and Centre National de la Recherche Scientifique (CNRS) ERL 8254 Bases Cellulaires et Moléculaires des Désordres Hématologiques ; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
keywords: ATLL; HTLV-1; HTLV-1 transmission; lymphoma; viral genotyping