title: Spatiotemporal patterning of polyamines in Drosophila development.
abstract: While several studies have implicated polyamines (PAs) in development, little research has been done in genetically tractable model systems like Drosophila. Here, we integrate transcriptional and metabolic data across Drosophila development, and are the first to show temporal, stage-specific regulation of PA accumulation in embryonic trachea and eye discs using immunohistochemistry. Understanding the regulation driving this accumulation can provide insight into PA metabolism and transport. Our findings suggest that Drosophila has great potential for investigating PAs in developmental biology.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Notre Dame, 180 Fitzpatrick Hall of Engineering, Notre Dame, IN, 46556, USA.
authors.forename: Miranda
authors.initials: M
authors.lastname: Burnette
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Notre Dame, 180 Fitzpatrick Hall of Engineering, Notre Dame, IN, 46556, USA. jzartman@nd.edu.
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Zartman
mesh_terms: D000818:Animals; D019521:Body Patterning; D019295:Computational Biology; D004331:Drosophila melanogaster / Q000196:embryology*; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D049452:Green Fluorescent Proteins / Q000378:metabolism; D007150:Immunohistochemistry; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology; D011073:Polyamines / Q000737:chemistry*; D013095:Spermidine / Q000737:chemistry; D013096:Spermine / Q000737:chemistry; D013997:Time Factors; D014132:Trachea / Q000196:embryology; D014158:Transcription, Genetic
chemical_list: D011073:Polyamines; D049452:Green Fluorescent Proteins; D013096:Spermine; D013095:Spermidine
keywords: Drosophila; Embryogenesis; Eye imaginal disc; Polyamine metabolism; Spermidine; Spermine; Trachea