title: Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease and Pulmonary Fibrosis: Prevalence and Hemodynamic Differences in Lung Transplant Recipients at Transplant Center's Referral Time.
abstract: BACKGROUND
  Single or bilateral lung transplantation is a therapeutic procedure for end-stage lung diseases. In particular, in cases of chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis, patients can be referred to the transplant center late and with important comorbilities. Pulmonary hypertension (PH) associated with lung diseases not only is an index of poor outcome but also is an indication for bilateral procedure.
  
  
  METHODS
  We conducted a retrospective observational study. We analyzed right heart catheterization in a consecutive series of patients who underwent lung transplantation from 2006 to 2014 for end-stage COPD and pulmonary fibrosis.
  
  
  RESULTS
  We included in the study 73 patients (35 with fibrosis and 38 with COPD); prevalence of PH was higher in the COPD group (84.3% vs 31.4%), and with worse hemodynamic parameters (mean pulmonary artery pressure [30.3 mm Hg vs 24.1 mm Hg]). The majority of COPD patients presented mild or moderate PH, and fibrosis patients showed normal pulmonary arterial pressures.
  
  
  CONCLUSIONS
  COPD patients are referred to the Transplant Center with a higher prevalence of PH because of an echocardiographic screening or a late referral, but many patients survive on the waiting list and undergo the procedure. On the other hand, patients transplanted with interstitial diseases have a lower prevalence of PH; this can be explained by an earlier referral or a higher mortality on the waiting list and a more aggressive and rapidly progressing disease.
authors.affiliation: Division of Pneumology, Cardiothoracic Department, A.O.U. Città della Salute e della Scienza di Torino, Presidio Molinette, and University of Torino, Turin, Italy. Electronic address: psolidoro@cittadellasalute.to.it.
authors.forename: P
authors.initials: P
authors.lastname: Solidoro
authors.affiliation: Division of Pneumology, Cardiothoracic Department, A.O.U. Città della Salute e della Scienza di Torino, Presidio Molinette, and University of Torino, Turin, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Patrucco
authors.affiliation: Cardiac Surgery Department, Cardiothoracic Department, A.O.U. Città della Salute e della Scienza di Torino, Presidio Molinette, and University of Torino, Turin, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Bonato
authors.affiliation: Cardiac Surgery Department, Cardiothoracic Department, A.O.U. Città della Salute e della Scienza di Torino, Presidio Molinette, and University of Torino, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Boffini
authors.affiliation: Division of Pneumology, Cardiothoracic Department, A.O.U. Città della Salute e della Scienza di Torino, Presidio Molinette, and University of Torino, Turin, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Libertucci
authors.affiliation: Cardiac Surgery Department, Cardiothoracic Department, A.O.U. Città della Salute e della Scienza di Torino, Presidio Molinette, and University of Torino, Turin, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Ricci
authors.affiliation: School of Public Health, University of Torino, Turin, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Allara
authors.affiliation: Cardiac Surgery Department, Cardiothoracic Department, A.O.U. Città della Salute e della Scienza di Torino, Presidio Molinette, and University of Torino, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rinaldi
authors.affiliation: Division of Pneumology, Cardiothoracic Department, A.O.U. Città della Salute e della Scienza di Torino, Presidio Molinette, and University of Torino, Turin, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Bucca
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000706:statistics & numerical data; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D066027:Transplant Recipients; D014850:Waiting Lists / Q000401:mortality