title: [Ketamine-propofol sedation in circumcision].
abstract: OBJECTIVE
  to compare the therapeutic effects of ketamine alone or ketamine plus propofol on analgesia, sedation, recovery time, side effects in premedicated children with midazolam-ketamine-atropin who are prepared circumcision operation.
  
  
  METHODS
  60 American Society of Anaesthesiologists physical status I-II children, aged between 3 and 9 years, undergoing circumcision operations under sedation were recruited according to a randomize and double-blind institutional review board-approved protocol. Patients were randomized into two groups via sealed envelope assignment. Both groups were administered a mixture of midazolam 0.05mg/kg+ketamine 3mg/kg+atropine 0.02mg/kg intramuscularly in the presence of parents in the pre-operative holding area. Patients were induced with propofol-ketamine in Group I or ketamine alone in Group II.
  
  
  RESULTS
  in the between-group comparisons, age, weight, initial systolic blood pressure, a difference in terms of the initial pulse rate was observed (p>0.050). Initial diastolic blood pressure and subsequent serial measurements of 5, 10, 15, 20thmin, systolic blood pressure, diastolic blood pressure and pulse rate in ketamine group were significantly higher (p<0.050).
  
  
  CONCLUSIONS
  propofol-ketamine (Ketofol) provided better sedation quality and hemodynamy than ketamine alone in pediatric circumcision operations. We did not observe significant complications during sedation in these two groups. Therefore, ketofol appears to be an effective and safe sedation method for circumcision operation.
authors.affiliation: Kecioren Training Hospital, Ankara, Turquia. Electronic address: handandrhandan@yahoo.com.tr.
authors.forename: Handan
authors.initials: H
authors.lastname: Gulec
authors.affiliation: Kecioren Training Hospital, Ankara, Turquia.
authors.forename: Saziye
authors.initials: S
authors.lastname: Sahin
authors.affiliation: Kecioren Training Hospital, Ankara, Turquia.
authors.forename: Esra
authors.initials: E
authors.lastname: Ozayar
authors.affiliation: Kecioren Training Hospital, Ankara, Turquia.
authors.forename: Semih
authors.initials: S
authors.lastname: Degerli
authors.affiliation: Kecioren Training Hospital, Ankara, Turquia.
authors.forename: Fatma
authors.initials: F
authors.lastname: Bercin
authors.affiliation: Kecioren Training Hospital, Ankara, Turquia.
authors.forename: Osman
authors.initials: O
authors.lastname: Ozdemir
keywords: Cetamina‐propofol; Circumcision; Circuncisão; Ketamine–propofol; Sedation; Sedação