title: A review of spontaneous intracranial extradural hematoma in sickle-cell disease.
abstract: Sickle-cell disease is common among patients of Afro-Caribbean origin. Though it can precipitate neurological conditions, it only rarely causes neurosurgical problems, with very few reported cases. We describe the case of a 7-year-old girl with a background of sickle-cell disease (SCD) brought into an acute neurosurgical unit in extremis, signs of a raised ICP, and with no history of recent trauma. Following further investigations, an acute drop in the hemoglobin and hematocrit levels were noted, with the cause of her presentation being attributed to a sickling crisis causing skull convexity infarction and resulting in spontaneous bilateral extradural hematomas requiring emergency evacuation. We review the current literature and propose the pathophysiological mechanism behind this phenomenon.
authors.affiliation: Department of Neurosurgery, King's College Hospital, London, UK.
authors.forename: Samantha
authors.initials: S
authors.lastname: Hettige
authors.affiliation: Department of Neurosurgery, King's College Hospital, London, UK. asofela@doctors.org.uk.|c/o CL Chandler, Department of Neurosurgery, King's College Hospital, Denmark Hill, London, SE5 9RS, UK. asofela@doctors.org.uk.
authors.forename: Agbolahan
authors.initials: A
authors.lastname: Sofela
authors.affiliation: Department of Neurosurgery, King's College Hospital, London, UK.
authors.forename: Sanj
authors.initials: S
authors.lastname: Bassi
authors.affiliation: Department of Neurosurgery, King's College Hospital, London, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Chandler
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D002648:Child; D005260:Female; D006407:Hematoma, Epidural, Cranial / Q000209:etiology*; D006801:Humans
keywords: Extradural hematoma; Non-traumatic; Sickle-cell disease; Skull convexity infarct; Spontaneous