title: Association of atrial fibrillation with gene polymorphisms of connexin 40 and angiotensin II receptor type 1 in Chongming adults of Shanghai.
abstract: OBJECTIVE
  To characterized the gene polymorphisms of connexin 40 (cx40) and angiotensin II receptor type 1 (AT1R) in Chongming adults with atrial fibrillation (AF) and to explore their relationships with AF.
  
  
  METHODS
  82 patients with AF, and 82 subjects without AF were enrolled. Polymorphisms of cx40 G-44A and AT1 A1166C were detected. Moreover, several samples were randomly selected to validate the gene polymorphisms of cx40 and AT1.
  
  
  RESULTS
  Genotypes AA, AG and GG of cx40 G-44A were found in both AF patients and controls. The frequencies of genotypes AA, AG and GG were 39%, 29% and 32%, respectively, in AF patients and 31%, 35% and 34%, respectively in controls. The frequencies of alleles A and G were 54% and 46%, respectively in AF patients and 48% and 52%, respectively, in controls (P < 0.05). The risk for AF in patients with allele A increased 1.31 times (OR = 1.31, P < 0.05). The frequencies of genotypes AA, AC and CC were 88%, 8% and 4%, respectively in AF patients and 93%, 6% and 1%, respectively in controls. The frequencies of alleles A and C were 92% and 8%, respectively in AF patients and 96% and 4%, respectively in controls (P < 0.05). More AF patients had allele C as compared to controls. The risk for AF increased by 1.43 times in patients with allele C (OR = 1.43, P < 0.05).
  
  
  CONCLUSIONS
  There were relationships between gene polymorphisms of cx40 and AT1 and AF in Chongming adults. Allele A of cx40 G-44A and allele C of AT1 A1166C significantly increase the risk for AF.
authors.affiliation: Department of Cardiology, Xinhua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 202150, China.
authors.forename: Shuxin
authors.initials: S
authors.lastname: Hou
authors.affiliation: Department of Cardiology, Xinhua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 202150, China.
authors.forename: Yingmin
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Xinhua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 202150, China.
authors.forename: Damin
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Xinhua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 202150, China.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Cardiology, Xinhua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 202150, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yue
authors.affiliation: Department of Cardiology, Xinhua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 202150, China.
authors.forename: Jinchun
authors.initials: J
authors.lastname: Zhang
keywords: Atrial fibrillation; angiotensin ii receptor type 1; connexin; gene polymorphism