title: The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia.
abstract: It is controversial that uric acid (UA) levels are related to the severity of hypertension in preeclampsia (PE). Our aim in this study was to determine whether UA, xanthine oxidase activity (XOA), allantoin and nitrite levels are related to arterial blood pressure (BP) in PE. We formed a control group (n = 20) and a PE group (n = 20) for the study. Their BPs and plasma UA, XOA, allantoin and nitrite levels were measured. The values from the control and PE pregnant women were assessed via a Wilcoxon matched-pairs test. A Pearson correlation test was also performed. In addition, the diagnostic value of these tests was evaluated via receiver operating characteristic (ROC) analysis. The BP, UA, XOA and allantoin levels in the PE patients were found to be higher when compared with those of the pregnant controls. The UA, XOA and allantoin levels showed high correlations with BP in cases of PE. However, there was no superiority among the correlations. No differences were observed between the groups in terms of nitrite levels and the relationship between nitrite and BP. UA, XOA and allantoin levels may be high due to placental cell death because of abnormal trophoblastic activity observed in PE. Moreover, the reactive oxygen products that are created during the genetic material degradation may explain how UA, XOA and allantoin levels are related to BP. According to ROC analysis, UA, XOA and allantoin assays are reliable predictors for the determination of PE.
authors.affiliation: a Biochemistry Laboratory, Korkuteli State Hospital , Antalya , Turkey.
authors.forename: Oguz
authors.initials: O
authors.lastname: Elmas
authors.affiliation: b Department of Physiology , Faculty of Medicine, Mugla Sitki Kocman University , Mugla , Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Elmas
authors.affiliation: c Department of Biochemistry , Faculty of Medicine, Akdeniz University , Antalya , Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Aliciguzel
authors.affiliation: d Department of Obstetrics , Faculty of Medicine, Akdeniz University , Antalya , Turkey.
authors.forename: Tayyup
authors.initials: T
authors.lastname: Simsek
mesh_terms: D000328:Adult; D000481:Allantoin / Q000097:blood*; D062186:Arterial Pressure; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D009573:Nitrites / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D012372:ROC Curve; D012720:Severity of Illness Index; D014527:Uric Acid / Q000097:blood*; D014969:Xanthine Oxidase / Q000097:blood*; D055815:Young Adult
chemical_list: D009573:Nitrites; D014527:Uric Acid; D000481:Allantoin; D014969:Xanthine Oxidase
keywords: Allantoin; nitrite; preeclampsia; uric acid; xanthine oxidase activity