title: MiRNA-101 inhibits breast cancer growth and metastasis by targeting CX chemokine receptor 7.
abstract: Whereas miR-101 is involved in the development and progression of breast cancer, the underlying molecular mechanisms remain to be elucidated. Here, we report that miR-101 expression is inversely correlated with the clinical stage, lymph node metastasis and prognosis in breast cancers. Introduction of miR-101 inhibited breast cancer cell proliferation and invasion in vitro and suppressed tumor growth and lung metastasis of in vivo. CX chemokine receptor 7 (CXCR7) is a direct target of miR-101, positively correlating with the histological grade and the incidence of lymph node metastasis in breast cancer patients. The effects of miR-101 were mimicked and counteracted by CXCR7 depletion and overexpression, respectively. STAT3 signaling downstream of CXCR7 is involved in miR-101 regulation of breast cancer cell behaviors. These findings have implications for the potential application of miR-101 in breast cancer treatment.
authors.affiliation: Centre of Inflammation and Cancer Research, 150th Central Hospital of PLA, Luoyang, Henan 471031, China.|State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.|State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
authors.forename: Jun-Tang
authors.initials: JT
authors.lastname: Li
authors.affiliation: State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
authors.forename: Lin-Tao
authors.initials: LT
authors.lastname: Jia
authors.affiliation: Centre of Inflammation and Cancer Research, 150th Central Hospital of PLA, Luoyang, Henan 471031, China.
authors.forename: Ning-Ning
authors.initials: NN
authors.lastname: Liu
authors.affiliation: Centre of Inflammation and Cancer Research, 150th Central Hospital of PLA, Luoyang, Henan 471031, China.
authors.forename: Xiao-Shan
authors.initials: XS
authors.lastname: Zhu
authors.affiliation: Centre of Inflammation and Cancer Research, 150th Central Hospital of PLA, Luoyang, Henan 471031, China.
authors.forename: Qin-Qin
authors.initials: QQ
authors.lastname: Liu
authors.affiliation: Centre of Inflammation and Cancer Research, 150th Central Hospital of PLA, Luoyang, Henan 471031, China.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Centre of Inflammation and Cancer Research, 150th Central Hospital of PLA, Luoyang, Henan 471031, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.affiliation: Centre of Inflammation and Cancer Research, 150th Central Hospital of PLA, Luoyang, Henan 471031, China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
authors.forename: An-Gang
authors.initials: AG
authors.lastname: Yang
authors.affiliation: Centre of Inflammation and Cancer Research, 150th Central Hospital of PLA, Luoyang, Henan 471031, China.
authors.forename: Chun-Fang
authors.initials: CF
authors.lastname: Gao
mesh_terms: D000818:Animals; D017209:Apoptosis; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D057809:HEK293 Cells; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000517:prevention & control / Q000556:secondary; D008207:Lymphatic Metastasis; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D034622:RNA Interference; D054387:Receptors, CXCR / Q000235:genetics / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors; D014162:Transfection; D047368:Tumor Burden
chemical_list: C501896:ACKR3 protein, human; C534072:MIRN101 microRNA, human; D035683:MicroRNAs; D054387:Receptors, CXCR; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human
keywords: CXCR7; breast cancer; metastasis; miR-101; proliferation