title: Autosomal Translocation Patient Who Experienced Premature Menopause: A Case Report.
abstract: Premature ovarian failure (POF) is a condition in which the ovarian functions of hormone production and oocyte development become impaired before the typical age for menopause. POF and early menopause are present in a broad spectrum of gonad dysgenesis, from a complete cessation of ovarian function to an intermittent follicle maturation failure. Actually POF has been identified as a genetic entity (especially chromosome X), but data on genetic factors of premature menopause are limited. Until now, several cases revealed that inactivation of X chromosomes has an effect on ages of premature menopause and females with balanced or unbalanced X-autosome translocations can have several reproductive problems. On the other hand, there have been a few data that was caused by autosome-autosome translocation can lead. Therefore we report a relevant case of POF with translocation between chromosomes 1 and 4. She had her first menstrual period at the age of 12, and after 7 years she stopped menstruation. Chromosomal analysis showed 46, XX, t (1;4) (p22.3;q31.3). While evaluating this rare case, we could review various causes (especially genetic factors) of POF. To remind clinicians about this disease, we report a case of POF caused by autosome-autosome translocation with a literature review.
authors.affiliation: Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Tae-Hee
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Biomedical Laboratory Science, Soonchunhyang University College of Medical Sciences, Asan, Korea.
authors.forename: Yesol
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Biomedical Laboratory Science, Soonchunhyang University College of Medical Sciences, Asan, Korea.
authors.forename: Do-Won
authors.initials: DW
authors.lastname: Jeong
authors.affiliation: Department of Biomedical Laboratory Science, Soonchunhyang University College of Medical Sciences, Asan, Korea.
authors.forename: Eun-Gyeong
authors.initials: EG
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Dong-Su
authors.initials: DS
authors.lastname: Jeon
authors.affiliation: Department of Urology, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Jun-Mo
authors.initials: JM
authors.lastname: Kim
keywords: Autosomal translocation; Premature Ovarian Failure; Premature menopause