title: Autoradiographic and histopathological studies of boric acid-mediated BNCT in hepatic VX2 tumor-bearing rabbits: Specific boron retention and damage in tumor and tumor vessels.
abstract: Hepatoma is a malignant tumor that responds poorly to conventional therapies. Boron neutron capture therapy (BNCT) may provide a better way for hepatoma therapy. In this research, (10)B-enriched boric acid (BA, 99% (10)B) was used as the boron drug. A multifocal hepatic VX2 tumor-bearing rabbit model was used to study the mechanisms of BA-mediated BNCT. Autoradiography demonstrated that BA was selectively targeted to tumors and tumor vessels. Histopathological examination revealed the radiation damage to tumor-bearing liver was concentrated in the tumor regions during BNCT treatment. The selective killing of tumor cells and the destruction of the blood vessels in tumor masses may be responsible for the success of BA-mediated BNCT for liver tumors.
authors.affiliation: Department of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Taiwan, ROC; Department of Imaging Diagnosis, Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan, ROC.
authors.forename: C H
authors.initials: CH
authors.lastname: Yang
authors.affiliation: Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC.
authors.forename: Y T
authors.initials: YT
authors.lastname: Lin
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Taiwan, ROC.
authors.forename: Y H
authors.initials: YH
authors.lastname: Hung
authors.affiliation: Graduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taiwan, ROC.
authors.forename: J W
authors.initials: JW
authors.lastname: Liao
authors.affiliation: Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC.
authors.forename: J J
authors.initials: JJ
authors.lastname: Peir
authors.affiliation: Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC.
authors.forename: H M
authors.initials: HM
authors.lastname: Liu
authors.affiliation: Department of Radiology, Mackay Memorial Hospital, Hsinchu, Taiwan, ROC.
authors.forename: Y L
authors.initials: YL
authors.lastname: Lin
authors.affiliation: Department of Oncology, Taipei Veterans General Hospital, Taiwan, ROC.
authors.forename: Y M
authors.initials: YM
authors.lastname: Liu
authors.affiliation: Department of Oncology, Taipei Veterans General Hospital, Taiwan, ROC.
authors.forename: Y W
authors.initials: YW
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Taiwan, ROC.
authors.forename: K S
authors.initials: KS
authors.lastname: Chuang
authors.affiliation: Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC; Institute of Nuclear Engineering and Science, National Tsing Hua University, Taiwan, ROC.
authors.forename: F I
authors.initials: FI
authors.lastname: Chou
mesh_terms: D000818:Animals; D001345:Autoradiography; D001888:Boric Acids / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology / Q000532:radiotherapy*; D011817:Rabbits
chemical_list: D001888:Boric Acids; C032688:boric acid
keywords: Autoradiography; Boric acid-mediated BNCT; Hepatoma; Histopathological observation