title: New insights into ragweed pollen allergens.
abstract: Pollen allergens from short ragweed (Ambrosia artemisiifolia) cause severe respiratory allergies in North America and Europe. To date, ten short ragweed pollen allergens belonging to eight protein families, including the recently discovered novel major allergen Amb a 11, have been recorded in the International Union of Immunological Societies (IUIS) allergen database. With evidence that other components may further contribute to short ragweed pollen allergenicity, a better understanding of the allergen repertoire is a requisite for the design of proper diagnostic tools and efficient immunotherapies. This review provides an update on both known as well as novel candidate allergens from short ragweed pollen, identified through a comprehensive characterization of the ragweed pollen transcriptome and proteome.
authors.affiliation: Stallergenes, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France. vbordas@stallergenes.com.
authors.forename: Véronique
authors.initials: V
authors.lastname: Bordas-Le Floch
authors.affiliation: Stallergenes, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France. rgroeme@stallergenes.com.
authors.forename: Rachel
authors.initials: R
authors.lastname: Groeme
authors.affiliation: Stallergenes, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France. hchabre@stallergenes.com.
authors.forename: Henri
authors.initials: H
authors.lastname: Chabre
authors.affiliation: Stallergenes, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France. vbodo@stallergenes.com.
authors.forename: Véronique
authors.initials: V
authors.lastname: Baron-Bodo
authors.affiliation: Stallergenes, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France. enony@stallergenes.com.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Nony
authors.affiliation: Stallergenes, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France. lmascarell@stallergenes.com.
authors.forename: Laurent
authors.initials: L
authors.lastname: Mascarell
authors.affiliation: Stallergenes, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France. pmoingeon@stallergenes.com.
authors.forename: Philippe
authors.initials: P
authors.lastname: Moingeon
mesh_terms: D000485:Allergens / Q000276:immunology*; D031164:Ambrosia / Q000276:immunology*; D052179:Antigens, Plant / Q000276:immunology*; D006801:Humans; D010936:Plant Extracts / Q000276:immunology*; D040901:Proteomics; D018749:RNA, Plant / Q000737:chemistry; D059467:Transcriptome
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D010936:Plant Extracts; D018749:RNA, Plant; C433085:ragweed pollen
keywords: Allergens; Ambrosia artemisiifolia; Mass spectrometry; RNA sequencing; Short ragweed