title: Materno-foetal leptin and insulin-like growth factor in low birth weight   neonates.
abstract: Low birth weight (LBW) is a health concern in developing countries. Leptin and insulin-like growth factor-I (IGF-I) are factors that influence LBW. A case-control study was conducted at Medani hospital, Sudan. Cases were women who had LBW deliveries ( 2,500 g) and controls were women with normal-weight babies ( 2.500 – 4,000 g). Sociodemographic and obstetrical characteristics were gathered from both groups and leptin and IGF-I levels were measured by ELISA. Cases and controls (45 in each arm) were matched in their basic data. The median (interquartile) of maternal leptin levels [9.9 (1.9 – 21.8) vs. 16.0 (9.6 – 20.8), ng/ml; P0.001] and IGF-I [1.6 (0.7 – 20.0) vs. 6.1 (4.3 – 7.1) ng/ml ; P 0.001] were significantly lower in cases than in controls. Likewise, cord serum leptin [5.8 (2.1 – 12.6) vs. 20.0 (5.1 – 37.8) ng/ml; P0.001] and cord serum IGF-I [1.7 (1.3 – 2.0) vs. 6.9 (5.9 – 7.4) ng/ml; P0.001] levels were significantly lower in cases than in controls. Significant positive correlation was found between birth weight and cord leptin ( r0.398), maternal ( r0.795) and cord ( r0.863) IGF-I levels. Maternal and cord leptin and IGF-I levels were significantly lower in LBW babies.
authors.affiliation: Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Al-Zaeim Al-azhary University, Khartoum, Sudan.
authors.forename: A O M
authors.initials: AO
authors.lastname: Elzein
authors.forename: A A
authors.initials: AA
authors.lastname: Ali
authors.forename: H Z
authors.initials: HZ
authors.lastname: Hamdan
authors.forename: E M
authors.initials: EM
authors.lastname: Elhassan
authors.forename: N E M A
authors.initials: NE
authors.lastname: Shrif
authors.forename: I
authors.initials: I
authors.lastname: Adam
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000097:blood*; D055815:Young Adult
chemical_list: D020738:Leptin; D007334:Insulin-Like Growth Factor I