title: Doxorubicin-loaded magnetic nanoparticle clusters for chemo-photothermal treatment of the prostate cancer cell line PC3.
abstract: In addition to the conventional cancer treatment such as radiotherapy, chemotherapy and surgical management, nanomedicine-based approaches have attracted widespread attention in recent years. In this paper, a promising nanocarrier, magnetic nanoparticle clusters (MNCs) as porous materials which provided enough room on the surface, was developed for loading chemotherapeutic agent of doxorubicin (DOX). Moreover, MNCs are a good near-infrared (NIR) photothermal mediator. Thus, MNCs have great potential both in photothermal therapy (PTT) and drug delivery for chemo-photothermal therapy of cancer. We firstly explored the destruction of prostate cancer in vitro by the combination of PTT and chemotherapy using DOX@MNCs. Upon NIR irradiation at 808 nm, more cancer cells were killed when PC3 cells incubated with DOX@MNCs, owing to both MNCs-mediated photothermal ablation and cytotoxicity of light-triggered DOX release. Compared with PTT or chemotherapy alone, the chemo-photothermal therapy by DOX@MNCs showed a synergistically higher therapeutic efficacy.
authors.affiliation: Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
authors.forename: Weibing
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Zheng
authors.affiliation: School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai, 201203, China.
authors.forename: Shun
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China. Electronic address: xinghuanwang9@gmail.com.
authors.forename: Xinghuan
authors.initials: X
authors.lastname: Wang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use*; D006801:Humans; D008280:Magnetics; D008297:Male; D053758:Nanoparticles; D010789:Phototherapy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000628:therapy*
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin
keywords: Chemo-photothermal therapy; Magnetic nanoparticle clusters; Prostate cancer