title: Lessons from NK Cell Deficiencies in the Mouse.
abstract: Since their discovery in the late 1970s, in vivo studies on mouse natural killer (NK) cell almost entirely relied on the use of depleting antibodies and were associated with significant limitations. More recently, large-scale gene-expression analyses allowed the identification of NKp46 as one of the best markers of NK cells across mammalian species. Since then, NKp46 has been shown to be expressed on other subsets of innate lymphoid cells (ILCs) such as the closely related ILC1 and the mucosa-associated NCR(+) ILC3. Based on this marker, several mouse models specifically targeting NKp46-expressing cell have recently been produced. Here, we review recent advances in the generation of models of deficiency in NKp46-expressing cells and their use to address the role of NK cells in immunity, notably on the regulation of adaptive immune responses.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm, U1104, CNRS UMR7280, 13288, Marseille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Deauvieau
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm, U1104, CNRS UMR7280, 13288, Marseille, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Fenis
authors.affiliation: SANOFI-Pasteur, Campus Merieux, 69280, Marcy l'Etoile, France.
authors.forename: François
authors.initials: F
authors.lastname: Dalençon
authors.affiliation: SANOFI-Pasteur, Campus Merieux, 69280, Marcy l'Etoile, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Burdin
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm, U1104, CNRS UMR7280, 13288, Marseille, France.|Service d'Immunologie, Hôpital de la Conception, Assistance Publique - Hôpitaux de Marseille, 13385, Marseille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm, U1104, CNRS UMR7280, 13288, Marseille, France. kerdiles@ciml.univ-mrs.fr.
authors.forename: Yann
authors.initials: Y
authors.lastname: Kerdiles
mesh_terms: D000818:Animals; D000950:Antigens, Ly / Q000235:genetics*; D006801:Humans; D007109:Immunity; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D055627:Natural Cytotoxicity Triggering Receptor 1 / Q000172:deficiency / Q000235:genetics*
chemical_list: D000950:Antigens, Ly; D055627:Natural Cytotoxicity Triggering Receptor 1; C118384:Ncr1 protein, mouse