title: Ocular motor signatures of cognitive dysfunction in multiple sclerosis.
abstract: The anatomical and functional overlap between ocular motor command circuitry and the higher-order networks that form the scaffolding for cognition makes for a compelling hypothesis that measures of ocular motility could provide a means to sensitively interrogate cognitive dysfunction in people with multiple sclerosis (MS). Such an approach may ultimately provide objective and reproducible measures of cognitive dysfunction that offer an innovative capability to refine diagnosis, improve prognostication, and more accurately codify disease burden. A further dividend may be the validation and application of biomarkers that can be used in studies aimed at identifying and monitoring preventative, protective and even restorative properties of novel neurotherapeutics in MS. This Review discusses the utility of ocular motor measures in patients with MS to characterize disruption to wide-ranging networks that support cognitive function.
authors.affiliation: School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Wellington Road, Clayton, VIC 3800, Australia.|Department of Medicine, Royal Melbourne Hospital, Melbourne Brain Centre, University of Melbourne, Parkville, VIC 3050, Australia.
authors.forename: Joanne
authors.initials: J
authors.lastname: Fielding
authors.affiliation: School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Wellington Road, Clayton, VIC 3800, Australia.
authors.forename: Meaghan
authors.initials: M
authors.lastname: Clough
authors.affiliation: Departments of Neurology and Neurotherapeutics, University of Texas Southwestern School of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Shin
authors.initials: S
authors.lastname: Beh
authors.affiliation: Department of Medicine, Royal Melbourne Hospital, Melbourne Brain Centre, University of Melbourne, Parkville, VIC 3050, Australia.
authors.forename: Lynette
authors.initials: L
authors.lastname: Millist
authors.affiliation: Departments of Neurology and Neurotherapeutics, University of Texas Southwestern School of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Sears
authors.affiliation: Departments of Neurology and Neurotherapeutics, University of Texas Southwestern School of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Ashley N
authors.initials: AN
authors.lastname: Frohman
authors.affiliation: Monash School of Medicine, Monash University, Wellington Road, Clayton, VIC 3800, Australia.
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Lizak
authors.affiliation: Department of Medicine, Royal Melbourne Hospital, Melbourne Brain Centre, University of Melbourne, Parkville, VIC 3050, Australia.
authors.forename: Jayne
authors.initials: J
authors.lastname: Lim
authors.affiliation: Department of Anatomy and Neuroscience, Medical Building, University of Melbourne, Parkville, VIC 3010, Australia.
authors.forename: Scott
authors.initials: S
authors.lastname: Kolbe
authors.affiliation: Department of Bioengineering and Computer Science, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Rennaker
authors.affiliation: Departments of Neurology and Neurotherapeutics, University of Texas Southwestern School of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Teresa C
authors.initials: TC
authors.lastname: Frohman
authors.affiliation: Department of Medicine, Royal Melbourne Hospital, Melbourne Brain Centre, University of Melbourne, Parkville, VIC 3050, Australia.
authors.forename: Owen B
authors.initials: OB
authors.lastname: White
authors.affiliation: Departments of Neurology and Neurotherapeutics, University of Texas Southwestern School of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.|Department of Bioengineering and Computer Science, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA.
authors.forename: Elliot M
authors.initials: EM
authors.lastname: Frohman
mesh_terms: D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology*; D005133:Eye Movements / Q000502:physiology*; D006801:Humans; D009103:Multiple Sclerosis / Q000503:physiopathology* / Q000523:psychology*