title: The role of systemic inflammation linking maternal BMI to neurodevelopment in children.
abstract: Children of obese mothers are at increased risk of developmental adversities. Maternal obesity is linked to an inflammatory in utero environment, which, in turn, is associated with neurodevelopmental impairments in the offspring. This is an integrated mechanism review of animal and human literature related to the hypothesis that maternal obesity causes maternal and fetal inflammation, and that this inflammation adversely affects the neurodevelopment of children. We propose integrative models in which several aspects of inflammation are considered along the causative pathway linking maternal obesity with neurodevelopmental limitations.
authors.affiliation: Department of Health and Life Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands.|Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: Jelske W
authors.initials: JW
authors.lastname: van der Burg
authors.affiliation: Department of Pediatrics and Mother Infant Research Institute, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts.|Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
authors.forename: Sarbattama
authors.initials: S
authors.lastname: Sen
authors.affiliation: Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: Virginia R
authors.initials: VR
authors.lastname: Chomitz
authors.affiliation: Department of Health and Life Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands.
authors.forename: Jaap C
authors.initials: JC
authors.lastname: Seidell
authors.affiliation: Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Alan
authors.initials: A
authors.lastname: Leviton
authors.affiliation: Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.|Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.|Perinatal Epidemiology Unit, Hannover Medical School, Hannover, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Dammann
mesh_terms: D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology; D001321:Autistic Disorder / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001921:Brain / Q000196:embryology; D015984:Causality; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000209:etiology; D015986:Confounding Factors, Epidemiologic; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007249:Inflammation / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008954:Models, Biological; D065886:Neurodevelopmental Disorders / Q000209:etiology* / Q000503:physiopathology; D009765:Obesity / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011297:Prenatal Exposure Delayed Effects; D011618:Psychotic Disorders / Q000209:etiology; D012306:Risk
chemical_list: D015415:Biomarkers