title: Niche Applications of Irreversible Electroporation.
abstract: Irreversible electroporation (IRE) induces cell death by exposing it to high-voltage, low-energy DC current pulses. The mechanism of cell death and healing is a departure from the other existing technologies such as radiofrequency ablation, microwave ablation, and cryoablation. These thermal ablative technologies have several applications in oncology but have limitations that have also been established. IRE has shown promise to overcome some of these limitations and has enabled the use of an ablative technology in treating lesions close to the bile ducts and vasculature and in organs such as the pancreas. This review highlights some of the niche applications of IRE and the data so far.
authors.affiliation: Vascular Interventional Radiology, Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL, USA.
authors.forename: Shivank S
authors.initials: SS
authors.lastname: Bhatia
authors.affiliation: Vascular Interventional Radiology, Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL, USA.
authors.forename: Rahul
authors.initials: R
authors.lastname: Arya
authors.affiliation: Vascular Interventional Radiology, Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL, USA. Electronic address: gnarayanan@med.miami.edu.
authors.forename: Govindarajan
authors.initials: G
authors.lastname: Narayanan
mesh_terms: D055011:Ablation Techniques / Q000009:adverse effects / Q000295:instrumentation; D000368:Aged; D016923:Cell Death; D018274:Electroporation / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000473:pathology / Q000601:surgery*; D049268:Positron-Emission Tomography; D011183:Postoperative Complications / Q000209:etiology; D012307:Risk Factors; D025321:Surgery, Computer-Assisted / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: ablation; irreversible electroporation; niche application; pancreas; vascular