title: Neuroprotective effects of chrysin: From chemistry to medicine.
abstract: The World Health Organization estimated that the proportion of older people (over 60 years) will increase from 11% to 22% during next 40 years throughout the world. With respect to this, the morbidity and mortality rates of age-related diseases will increase. Mental diseases are the most common and important health problems among elderly people. Therefore, much attention has been paid to the discovery of neuroprotective drugs with high efficacy and negligible adverse effects. A growing body of scientific evidence has shown that phytochemicals possess neuroprotective effects and also mitigate neurodegeneration under both in vivo and in vitro conditions. Polyphenolic compounds, especially flavonoids, are known as most common chemical class of phytochemicals which possess a multiple range of health promoting effects. Chrysin, belonging to the flavone class, is one of the most important bioactive constituents of different fruits, vegetables and even mushrooms. Chrysin possesses potent neuroprotective effects and suppress neuroinflammation. In addition, chrysin improves cognitive decline and possesses a potent anti-amyloidogenic and neurotrophic effects. Furthermore, beneficial effects of chrysin on both depression and epilepsy have been reported. The present paper aimed to critically review the available literature data regarding the neuroprotective effects of chrysin as well as its chemistry, sources and bioavailability.
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Australia.
authors.forename: Nady
authors.initials: N
authors.lastname: Braidy
authors.affiliation: Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Kent, UK.
authors.forename: Solomon
authors.initials: S
authors.lastname: Habtemariam
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
authors.forename: Ilkay Erdogan
authors.initials: IE
authors.lastname: Orhan
authors.affiliation: Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Daglia
authors.affiliation: Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Manayi
authors.affiliation: Department of Food Technology, Technological Educational Institution of Thessaly Terma N. Temponera Str. Greece.
authors.forename: Olga
authors.initials: O
authors.lastname: Gortzi
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D018696:Neuroprotective Agents; D014409:Tumor Necrosis Factor-alpha; C043561:chrysin
keywords: Antioxidant; Chrysin; Depression; Epilepsy; Neurodegeneration; Neuroprotective