title: [Treatment of Sepsis-associated Encephalopathy by Xingnaojing Injection: a Clinical Observation].
abstract: OBJECTIVE
  To observe the efficacy of Xingnaojing Injection (XI) in treatment of sepsis-associated encephalopathy (SAE).
  
  
  METHODS
  Totally 65 SAE patients were retrospectively analyzed at EICU from September 2010 to September 2013. They were assigned to the control group (32 cases) and the treatment group (33 cases) according to whether they received XI. Patients in the control group received anti-infection and symptomatic support, while those in the treatment group were intravenously injected with XI at 20 mL per day for additional 7-10 days. The fever clearance time, Glasgow coma scale (GCS), C-reactive protein (CRP), neuron-specific enolase (NSE), and improvement of electroen-cephalogram (EEG) were observed in the two groups.
  
  
  RESULTS
  Compared with the control group, the fever clearance time was shortened, CRP levels decreased, GCS score and efficacy of EEG was alleviated in the treatment group after treatment with statistical difference (P < 0.05). No adverse reaction occurred during medication.
  
  
  CONCLUSIONS
  X1 was safe and effective in treatment of SAE.
authors.forename: Su
authors.initials: S
authors.lastname: Lv
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Bao-ping
authors.initials: BP
authors.lastname: Cao
authors.forename: Ji-hong
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D065166:Sepsis-Associated Encephalopathy / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; C000594497:xingnaojing; D002097:C-Reactive Protein; D010751:Phosphopyruvate Hydratase