title: A Nodular Foreign Body Reaction in a Dialysis Patient Receiving Long-term Treatment With Lanthanum Carbonate.
abstract: A 63-year-old man with HIV (human immunodeficiency virus) infection and end-stage renal disease, treated with lanthanum carbonate phosphate binder for 4 years, presented with anemia and an upper gastrointestinal bleed. Upper endoscopy revealed a nodular hyperplastic epithelium, with an endoscopic ultrasound confirming hyperechoic material within the nodules. Light microscopy showed collections of histiocytes and multinucleated giant cells containing brown granular cytoplasmic material and extracellular crystalline material, a finding confirmed by electron microscopy. Similar pathologic findings associated with lanthanum exposure have been described recently. In our patient, lanthanum carbonate treatment was withdrawn and gastrointestinal bleeding has since ceased. The patient was exposed to a high amount of lanthanum over a long period, which may explain his adverse reaction. However, other contributing factors, such as competing medications or comorbid conditions, also may have increased his sensitivity to the drug.
authors.affiliation: Section of Nephrology, Yale University School of Medicine, New Haven, CT.
authors.forename: Aziz K
authors.initials: AK
authors.lastname: Valika
authors.affiliation: Section of Nephrology, Yale University School of Medicine, New Haven, CT.
authors.forename: Dhanpat
authors.initials: D
authors.lastname: Jain
authors.affiliation: Gastroenterology Center of CT, Hamden, CT.
authors.forename: Phillip E
authors.initials: PE
authors.lastname: Jaffe
authors.affiliation: Section of Nephrology, Yale University School of Medicine, New Haven, CT.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Moeckel
authors.affiliation: Section of Nephrology, Internal Medicine, Yale University School of Medicine, New Haven, CT. Electronic address: ursula.brewster@yale.edu.
authors.forename: Ursula C
authors.initials: UC
authors.lastname: Brewster
mesh_terms: D005549:Foreign-Body Reaction / Q000139:chemically induced*; D006801:Humans; D007811:Lanthanum / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: C119467:lanthanum carbonate; D007811:Lanthanum
keywords: Lanthanum carbonate; dialysis; end-stage renal disease (ESRD); foreign-body reaction; histiocytosis; hyperphosphatemia; phosphate binder; upper gastrointestinal bleed