title: Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure.
abstract: BACKGROUND
  Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF.
  
  
  METHODS
  Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n=3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission.
  
  
  RESULTS
  Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p<0.001) and chronic kidney disease (14.1% vs. 5.7%, p<0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p=0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend=0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p=0.013).
  
  
  CONCLUSIONS
  Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.
authors.affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
authors.forename: Jun-Won
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Youn
authors.affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
authors.forename: Min Soo
authors.initials: MS
authors.lastname: Ahn
authors.affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
authors.forename: Sung Gyun
authors.initials: SG
authors.lastname: Ahn
authors.affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
authors.forename: Jang Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
authors.forename: Junghan
authors.initials: J
authors.lastname: Yoon
authors.affiliation: Division of Cardiology, Yonsei University Severance Hospital, Seoul, Republic of Korea.
authors.forename: Jaewon
authors.initials: J
authors.lastname: Oh
authors.affiliation: Division of Cardiology, Yonsei University Severance Hospital, Seoul, Republic of Korea.
authors.forename: Seok-Min
authors.initials: SM
authors.lastname: Kang
authors.affiliation: Division of Cardiology, Sungkyunkwan University Samsung Medical Center, Seoul, Republic of Korea.
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Jeon
authors.affiliation: Division of Cardiology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors.forename: Dong-Ju
authors.initials: DJ
authors.lastname: Choi
authors.affiliation: Division of Cardiology, Hallym University Medical Center, Hwaseong, Republic of Korea.
authors.forename: Kyu-Hyung
authors.initials: KH
authors.lastname: Ryu
authors.affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea. Electronic address: yubs@yonsei.ac.kr.
authors.forename: Byung-Su
authors.initials: BS
authors.lastname: Yoo
mesh_terms: D000368:Aged; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D054143:Heart Failure, Systolic / Q000401:mortality*; D006760:Hospitalization; D006801:Humans; D006973:Hypertension / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012042:Registries; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D056910:Republic of Korea / Q000453:epidemiology; D013599:Systole
keywords: Heart failure; Hypertension; Systolic blood pressure