title: Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake.
abstract: A high salt intake exacerbates hypertension and accelerates renal tubular damage in hypertensive patients. However, data concerning early biomarkers for renal tubular change induced by a high salt intake are limited. The objective of this study was to clarify the time course of new biomarkers for renal tubular damage during high salt intake in spontaneously hypertensive rats (SHR). Male SHR received a regular or high-salt diet from 9 to 17 weeks of age. At 10 weeks of age, a high salt intake caused renal tubular damage, which was further exacerbated at 17 weeks of age. Although albuminuria was detected in salt-loaded SHR at 14 weeks of age, urinary excretion of vanin-1 and neutrophil gelatinase-associated lipocalin (NGAL) was elevated in these animals from 10-17 weeks of age. However, kidney injury molecule-1 (Kim-1) was elevated at 15 weeks of age in salt-loaded SHR. These results suggest that urinary vanin-1 and NGAL are potentially early biomarkers for renal tubular damage in SHR under a high salt intake.
authors.affiliation: Departments of Clinical Pharmacolo.gy, School of Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Hosohata
authors.affiliation: Departments of Clinical Pharmacolo.gy, School of Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshioka
authors.affiliation: Departments of Pathology, School of Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Departments of Clinical Pharmacolo.gy, School of Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ando
authors.affiliation: Departments of Clinical Pharmacolo.gy, School of Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000209:Acute-Phase Proteins / Q000652:urine; D000419:Albuminuria / Q000378:metabolism; D000581:Amidohydrolases / Q000652:urine; D000818:Animals; D015415:Biomarkers / Q000652:urine*; D001794:Blood Pressure / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000652:urine; D003404:Creatinine / Q000652:urine; D058851:GPI-Linked Proteins / Q000652:urine; D006973:Hypertension / Q000473:pathology* / Q000652:urine*; D007684:Kidney Tubules / Q000473:pathology*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine; D008297:Male; D011518:Proto-Oncogene Proteins / Q000652:urine; D051381:Rats; D011918:Rats, Inbred SHR; D017673:Sodium Chloride, Dietary / Q000633:toxicity*
chemical_list: D000209:Acute-Phase Proteins; D000581:Amidohydrolases; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D003404:Creatinine; D058851:GPI-Linked Proteins; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D017673:Sodium Chloride, Dietary; C110936:Havcr1 protein, rat; C097278:Lcn2 protein, rat; C022314:pantetheinase