title: Small-molecule bioanalytical sample preparation method development starting from the BASICS.
abstract: OBJECTIVE
  To develop a robust small-molecule bioanalytical sample preparation method, systematic investigations of the bioanalytical handling conditions of analytes and IS of interest are preferred. So far, such investigations are done manually and are labor-intensive and error-prone.
  
  
  RESULTS
  An automation-assisted system has been developed to facilitate such systematic investigations. The system takes experimental design and automates the majority of the wet laboratory work. In addition, the system also automates the data extraction, recovery/loss computation, graphing and reporting.
  
  
  CONCLUSIONS
  The automation-assisted system greatly reduces errors and labor involved in the systematic investigation of analytes and IS both for wet chemistry experiments and for data extraction and processing, enhances data processing efficiency and overall sample preparation method development productivity.
authors.affiliation: Biogen, 250 Binney Street, Cambridge, MA 02142, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Biogen, 250 Binney Street, Cambridge, MA 02142, USA.
authors.forename: Judy
authors.initials: J
authors.lastname: Chou
authors.affiliation: Biogen, 250 Binney Street, Cambridge, MA 02142, USA.
authors.forename: Kristopher W
authors.initials: KW
authors.lastname: King
authors.affiliation: Biogen, 250 Binney Street, Cambridge, MA 02142, USA.
authors.forename: Liyu
authors.initials: L
authors.lastname: Yang