title: Silica nanoparticle-based dual imaging colloidal hybrids: cancer cell imaging and biodistribution.
abstract: In this study, fluorescent dye-conjugated magnetic resonance (MR) imaging agents were investigated in T mode. Gadolinium-conjugated silica nanoparticles were successfully synthesized for both MR imaging and fluorescence diagnostics. Polyamine and polycarboxyl functional groups were modified chemically on the surface of the silica nanoparticles for efficient conjugation of gadolinium ions. The derived gadolinium-conjugated silica nanoparticles were investigated by zeta potential analysis, transmission electron microscopy, inductively coupled plasma mass spectrometry, and energy dispersive x-ray spectroscopy. MR equipment was used to investigate their use as contrast-enhancing agents in T1 mode under a 9.4 T magnetic field. In addition, we tracked the distribution of the gadolinium-conjugated nanoparticles in both lung cancer cells and organs in mice.
authors.affiliation: Molecular Diagnostics, In Vitro Diagnostics Unit, New Business Division, SK Telecom, Republic of Korea.
authors.forename: Haisung
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Life Sciences, Graduate School of Korea University, Seoul, Republic of Korea.
authors.forename: Dongkyung
authors.initials: D
authors.lastname: Sung
authors.affiliation: Interdisciplinary Graduate Program of Biomedical Engineering, School of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea.
authors.forename: Jinhoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Interdisciplinary Graduate Program of Biomedical Engineering, School of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea.
authors.forename: Byung-Tae
authors.initials: BT
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Myongji University, Seoul, Republic of Korea.
authors.forename: Tuntun
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, Republic of Korea.
authors.forename: Seong Soo A
authors.initials: SS
authors.lastname: An
authors.affiliation: Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea.
authors.forename: Soo-Won
authors.initials: SW
authors.lastname: Seo
authors.affiliation: Department of Chemistry, Myongji University, Seoul, Republic of Korea.
authors.forename: Dong Kee
authors.initials: DK
authors.lastname: Yi
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003102:Colloids / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D003102:Colloids; D003287:Contrast Media; D012822:Silicon Dioxide
keywords: MR imaging; T1 contrast imaging; dual bioimaging; nanohybrid; silica colloid