title: Noninvasive Imaging of Flow and Vascular Function in Disease of the Aorta.
abstract: With advancements in technology and a better understanding of human cardiovascular physiology, research as well as clinical care can go beyond dimensional anatomy offered by traditional imaging and investigate aortic functional properties and the impact disease has on this function. Linking the knowledge of the histopathological changes with the alterations in aortic function observed on noninvasive imaging results in a better understanding of disease pathophysiology. Translating this to clinical medicine, these noninvasive imaging assessments of aortic function are proving to be able to diagnose disease, better predict risk, and assess response to therapies. This review is designed to summarize the various hemodynamic measures that can characterize the aorta, the various noninvasive techniques, and applications for various disease states.
authors.affiliation: Department of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Whitlock
authors.affiliation: Department of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Radiological Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina. Electronic address: ghundley@wakehealth.edu.
authors.forename: W Gregory
authors.initials: WG
authors.lastname: Hundley
mesh_terms: D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001018:Aortic Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D001027:Aortography; D001696:Biomechanical Phenomena; D003952:Diagnostic Imaging / Q000379:methods*; D004452:Echocardiography; D006439:Hemodynamics; D006801:Humans; D018810:Magnetic Resonance Angiography; D008955:Models, Cardiovascular; D011237:Predictive Value of Tests; D011379:Prognosis; D012039:Regional Blood Flow; D014057:Tomography, X-Ray Computed
keywords: aorta; aorta hemodynamics; aortic disease; distensibility; pulse wave velocity