title: Assessment of Liver and Spleen Stiffness in Patients With Myelofibrosis Using FibroScan and Shear Wave Elastography.
abstract: Liver stiffness and spleen stiffness in patients with myelofibrosis have traditionally been assessed through manual palpation and thus influenced by interobserver variability. In this article, for the first time, liver stiffness and spleen stiffness of patients with myelofibrosis were evaluated through FibroScan and shear wave elastography (SWE). Nine patients with myelofibrosis comprised the study group. They were compared with 11 patients with liver cirrhosis and 8 healthy volunteers. Before the FibroScan study, all patients underwent ultrasound study to delineate the left intercostal space for validated measurements. In patients with myelofibrosis, the mean stiffness of the spleen was 41.3 and 32.9 kilopascals (kPa) through FibroScan and SWE, respectively. The mean stiffness of the liver was 7.8 kPa through FibroScan and 10.4 kPa through SWE. The stiffness of the spleen in patients with cirrhosis was even higher, reaching a mean of 58.5 kPa through FibroScan and 40.5 kPa through SWE. The means were considerably lower among the healthy controls (13.5 and 18.1 kPa, respectively). The correlation between spleen stiffness among the patients with cirrhosis is negative and opposite in direction (r = -0.35) in comparison with the patients with myelofibrosis (r = 0.78). Among the patients with liver cirrhosis and myelofibrosis, spleen size was weakly related to spleen stiffness as assessed through SWE (r = 0.49) but had almost no relation to the FibroScan measure (r = 0.13). The FibroScan and SWE of the spleen have little ability to distinguish between the patients with myelofibrosis and cirrhosis, but they do differentiate both patient groups from the healthy controls. The stiffness of spleen and liver as measured through FibroScan and SWE was not correlated to the longevity of myelofibrosis.
authors.affiliation: *Department of Gastroenterology, Tel Aviv Medical Center; †Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; ‡Hematology Laboratory, Sheba Medical Center, Tel Hashomer; §Department of Statistics and Operations Research, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv; and ∥Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Muriel
authors.initials: M
authors.lastname: Webb
authors.forename: Oren
authors.initials: O
authors.lastname: Shibolet
authors.forename: Zamir
authors.initials: Z
authors.lastname: Halpern
authors.forename: Meital
authors.initials: M
authors.lastname: Nagar
authors.forename: Ninette
authors.initials: N
authors.lastname: Amariglio
authors.forename: Stella
authors.initials: S
authors.lastname: Levit
authors.forename: David M
authors.initials: DM
authors.lastname: Steinberg
authors.forename: Erwin
authors.initials: E
authors.lastname: Santo
authors.forename: Ophira
authors.initials: O
authors.lastname: Salomon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008099:Liver / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D055728:Primary Myelofibrosis / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D013154:Spleen / Q000000981:diagnostic imaging* / Q000503:physiopathology*