title: Targeting B-cell maturation antigen in multiple myeloma.
abstract: Novel effective immunotherapies are needed for patients with multiple myeloma (MM), since disease recurrence remains a major obstacle. B-cell maturation antigen (BCMA), a cell surface protein universally expressed on malignant plasma cells , has emerged as a very selective antigen to be targeted in novel treatments for MM. We here first review BCMA-related biology, and then highlight the recent clinical development of a novel afucosylated anti-BCMA monoclonal antibody conjugated with monomethyl auristatin F via noncleavable linker (GSK2857916). Chimeric antigen receptor-expressing T cells targeting BCMA may also induce specific and durable anti-MM responses by patients' own effector cells. Clinical trials testing these two approaches (NCT02064387, NCT02215967) are currently ongoing in relapsed and refractory MM patients.
authors.affiliation: Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA.
authors.forename: Yu-Tzu
authors.initials: YT
authors.lastname: Tai
authors.affiliation: Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA.
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Anderson
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism*; D053301:B-Cell Maturation Antigen / Q000276:immunology / Q000378:metabolism*; D002986:Clinical Trials as Topic; D006801:Humans; D007167:Immunotherapy; D058990:Molecular Targeted Therapy; D009101:Multiple Myeloma / Q000276:immunology / Q000628:therapy*; D009842:Oligopeptides / Q000737:chemistry; D015202:Protein Engineering; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D053301:B-Cell Maturation Antigen; D009842:Oligopeptides; D011948:Receptors, Antigen, T-Cell; D011993:Recombinant Fusion Proteins; C086966:TNFRSF17 protein, human; C513576:monomethylauristatin F
keywords: ADC; B-cell maturation antigen; BCMA; BM; CAR-T; CAR-expressing T cells; Fc-engineered therapeutic antibody; MM; antibody drug conjugate; bone marrow; chimeric antigen receptor; microenvironment; multiple myeloma; targeted immunotherapy