title: Estimating Ring Strain Energies of Highly Substituted Cyclohexanes with the Semi-homodesmotic Approach: Why Substantial Ring Strain Exists for Nominally Tetrahedral Ring Carbon Atoms.
abstract: Estimation of ring strain energies (RSEs) of substituted cyclohexanes c-C6H(x)R(12-x) (R = F, Cl, Me; x = 0, 2, 4, 8, 10, 12) using homodesmotic reaction methods gives implausible results for highly substituted cases, particularly, c-C6R12. Prior work suggests that this stems from poorly canceled interactions between substituents on the acyclic reference molecules. We apply here our semi-homodesmotic approach that minimizes use of acyclic references and ensures cancellation of intramolecular substituent interactions. The approach provides RSEs that are more consistent with chemical intuition, although they are higher than expected for "strain-free" cyclohexanes. The RSE for c-C6Me12 is predicted to be 11.9 kcal mol(-1). RSEs for halogenated rings rise significantly from 8-9 kcal mol(-1) for c-1,1,2,2-C6H8R4 to 44-50 kcal mol(-1) for c-C6R12 (R = F, Cl). The increase, and accompanying observation of larger RSEs for "adjacent CR2" systems, can be tied to increased bond distances in the rings upon progressive substitution. The sizable RSE for perchlorocyclohexane suggests that it may be susceptible to ring-opening reactions, a facet of its chemistry that is currently unexplored.
authors.affiliation: Department of Chemistry and Biochemistry, Northern Illinois University , DeKalb, Illinois 60115 United States.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: De Lio
authors.affiliation: Department of Chemistry and Biochemistry, Northern Illinois University , DeKalb, Illinois 60115 United States.
authors.forename: Bridget L
authors.initials: BL
authors.lastname: Durfey
authors.affiliation: Department of Chemistry and Biochemistry, Northern Illinois University , DeKalb, Illinois 60115 United States.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Gilbert