title: Circadian rhythm in Alzheimer disease after trazodone use.
abstract: A circadian rhythm is a cycle of approximately 24 h, responsible for many physiological adjustments, and ageing of the circadian clock contributes to cognitive decline. Rhythmicity is severely impaired in Alzheimer disease (AD) and few therapeutic attempts succeeded in improving sleep disorders in such context. This study evaluated sleep parameters by actigraphy in 30 AD patients before and after trazodone use for 2 weeks, and we show a significant improvement in relative rhythm amplitude (RRA), compatible with a more stable daytime behavioral pattern. So, trazodone appears to produce a stabilization of the circadian rhythms in individuals with AD.
authors.affiliation: a Geriatric Medical Centre, Brasilia University Hospital, University of Brasilia , Brasília , Brazil .
authors.forename: Talyta C
authors.initials: TC
authors.lastname: Grippe
authors.affiliation: b Department of Physiology , Bioscience Center, Federal University of Rio Grande do Norte , Natal , Brazil .
authors.forename: Bruno S B
authors.initials: BS
authors.lastname: Gonçalves
authors.affiliation: a Geriatric Medical Centre, Brasilia University Hospital, University of Brasilia , Brasília , Brazil .
authors.forename: Luciana L
authors.initials: LL
authors.lastname: Louzada
authors.affiliation: a Geriatric Medical Centre, Brasilia University Hospital, University of Brasilia , Brasília , Brazil .
authors.forename: Juliana L
authors.initials: JL
authors.lastname: Quintas
authors.affiliation: a Geriatric Medical Centre, Brasilia University Hospital, University of Brasilia , Brasília , Brazil .|c Graduation Program in Health Sciences, Pharmacy School , and.
authors.forename: Janeth O S
authors.initials: JO
authors.lastname: Naves
authors.affiliation: a Geriatric Medical Centre, Brasilia University Hospital, University of Brasilia , Brasília , Brazil .|d Graduation Program in Medical Sciences, University of Brasilia , Brasília , Brazil.
authors.forename: Einstein F
authors.initials: EF
authors.lastname: Camargos
authors.affiliation: a Geriatric Medical Centre, Brasilia University Hospital, University of Brasilia , Brasília , Brazil .|d Graduation Program in Medical Sciences, University of Brasilia , Brasília , Brazil.
authors.forename: Otávio T
authors.initials: OT
authors.lastname: Nóbrega
mesh_terms: D056044:Actigraphy; D000204:Activity Cycles / Q000187:drug effects*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D012890:Sleep / Q000187:drug effects*; D020178:Sleep Disorders, Circadian Rhythm / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D014196:Trazodone / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014196:Trazodone
keywords: Alzheimer’s disease; Sleep disorders; chronobiology; circadian rhythm; dementia; outpatient care