title: Reproducibility of a Parkinsonism-related metabolic brain network in non-human primates: A descriptive pilot study with FDG PET.
abstract: BACKGROUND
  We have previously defined a parkinsonism-related metabolic brain network in rhesus macaques using a high-resolution research positron emission tomography camera. This brief article reports a descriptive pilot study to assess the reproducibility of network activity and regional glucose metabolism in independent parkinsonian macaques using a clinical positron emission tomography/CT camera.
  
  
  METHODS
  [(18)F]fluorodeoxyglucose PET scans were acquired longitudinally over 3 months in three drug-naïve parkinsonian and three healthy control cynomolgus macaques. Group difference and test-retest stability in network activity and regional glucose metabolism were evaluated graphically, using all brain images from these macaques.
  
  
  RESULTS
  Comparing the parkinsonian macaques with the controls, network activity was elevated and remained stable over 3 months. Normalized glucose metabolism increased in putamen/globus pallidus and sensorimotor regions but decreased in posterior parietal cortices.
  
  
  CONCLUSIONS
  Parkinsonism-related network activity can be reliably quantified in different macaques with a clinical positron emission tomography/CT scanner and is reproducible over a period typically employed in preclinical intervention studies. This measure can be a useful biomarker of disease process or drug effects in primate models of Parkinson's disease.
authors.affiliation: Center for Neurosciences, the Feinstein Institute fo Medical Research, Manhasset, NY, USA.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
authors.forename: Tom H
authors.initials: TH
authors.lastname: Johnston
authors.affiliation: Center for Neurosciences, the Feinstein Institute fo Medical Research, Manhasset, NY, USA.
authors.forename: Shichun
authors.initials: S
authors.lastname: Peng
authors.affiliation: PET Center of Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Chuantao
authors.initials: C
authors.lastname: Zuo
authors.affiliation: Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
authors.forename: James B
authors.initials: JB
authors.lastname: Koprich
authors.affiliation: Movement Disorder Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
authors.forename: Susan H
authors.initials: SH
authors.lastname: Fox
authors.affiliation: PET Center of Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Center for Neurosciences, the Feinstein Institute fo Medical Research, Manhasset, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Eidelberg
authors.affiliation: Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Brotchie
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001931:Brain Mapping; D004195:Disease Models, Animal; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005947:Glucose / Q000378:metabolism*; D020267:MPTP Poisoning / Q000000981:diagnostic imaging* / Q000473:pathology*; D008252:Macaca fascicularis; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D011328:Prions / Q000378:metabolism*; D011859:Radiography; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D011328:Prions; D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: Parkinson's disease; animal models; brain imaging biomarker; glucose metabolism; position emission tomography