title: A self-assembled nanotube for the direct aldol reaction in water.
abstract: Nanotubes formed by the aqueous assembly of a proline-lysine dipeptide (1) were used to create the hydrophobic microenvironments required to catalyze the aldol reaction in water. The self-assembly process occurred most efficiently in the presence of the substrates, producing an array of homogeneous nanotubes under the reaction conditions. The nanotubes formed by dipeptide 1 served as an efficient catalyst for the aldol reaction that functioned at low loading levels and provided good to excellent conversions. The catalytic activity of 1 was minimal under conditions that dissociated the nanotube into soluble monomers.
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 151 W. Woodruff Ave., Columbus, OH 43210, USA. parquette.1@osu.edu.
authors.forename: Kwang Soo
authors.initials: KS
authors.lastname: Lee
authors.forename: Jon R
authors.initials: JR
authors.lastname: Parquette
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008239:Lysine / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D011392:Proline / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D001547:Benzaldehydes; D003512:Cyclohexanones; D004151:Dipeptides; D014867:Water; C029915:4-nitrobenzaldehyde; C036468:cyclohexanone; D011392:Proline; D008239:Lysine