title: Identification of a shared protective genetic susceptibility locus for colorectal cancer and gastric cancer.
abstract: Risk of both colorectal cancer (CRC) and gastric cancer (GC) is considered to be heritable with mounting evidence for their genetic susceptibility. However, it remains unknown whether a shared genetic background is underlying these two cancers. A total of ten single nucleotide polymorphisms (SNPs) associated with digestive system cancers risk were selected from previous genome-wide association studies. All SNPs were genotyped in 449 CRC cases, 588 GC cases, and 703 controls using Sequenom Mass-ARRAY technology. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were estimated using unconditional logistic regression analysis with adjustment for age and gender, and evaluated their association with both cancers in a Han Chinese population using chi-squared (χ (2)) test and genetic model analysis. By χ (2) test, we found that rs2057314 (p = 0.028; OR = 1.21) was significantly associated with an increased risk of CRC, rs7758229 (p = 0.005; OR = 0.77) was significantly associated with a decreased risk of GC. Furthermore, a shared susceptibility locus rs9502893 was found to have significant protective effect against CRC (p = 0.010; OR = 0.80) and GC (p = 0.0003; OR = 0.74). Our findings could provide insight into the underlying shared a partly overlapping genetic aspect of CRC and GC in a Chinese population. Additional studies are required to verify and discover more common genetic variants associated with risk for digestive system cancers.
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, Shaanxi, 712082, China.|Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, China.
authors.forename: Na
authors.initials: N
authors.lastname: He
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, Shaanxi, 712082, China.|Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of General Surgery, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, 710068, China.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Duan
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, Shaanxi, 712082, China.|Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, Shaanxi, 712082, China.|Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, China.
authors.forename: Dongya
authors.initials: D
authors.lastname: Yuan
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, Shaanxi, 712082, China. tianbojin_2011@163.com.|Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, China. tianbojin_2011@163.com.|School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China. tianbojin_2011@163.com.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, Shaanxi, 712082, China. longlikang_2012@163.com.|Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Diseases of the Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, China. longlikang_2012@163.com.
authors.forename: Longli
authors.initials: L
authors.lastname: Kang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*
keywords: Colorectal cancer; Gastric cancer; Single nucleotide polymorphism; Susceptibility