title: Manganese-Catalyzed Direct Nucleophilic C(sp(2))-H Addition to Aldehydes and Nitriles.
abstract: Herein, a manganese-catalyzed nucleophilic addition of inert C(sp(2))-H bonds to aldehydes and nitriles is disclosed by virtue of a dual activation strategy. The reactions feature mild reaction conditions, excellent regio- and stereoselectivity, and a wide substrate scope, which includes both aromatic and olefinic C-H bonds, as well as a large variety of aldehydes and nitriles. Moreover, mechanistic studies shed light on possible catalytic cycles.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China).
authors.forename: Bingwei
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China).
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China). wangcy@iccas.ac.cn.
authors.forename: Congyang
authors.initials: C
authors.lastname: Wang
keywords: CH activation; Lewis acids; alcohols; carbonyl compounds; manganese