title: Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk.
abstract: BACKGROUND
  Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants for other common cancers are associated with risk of esophageal adenocarcinoma (EA) or its precursor, Barrett's esophagus.
  
  
  METHODS
  We examined the associations between risks of EA and Barrett's esophagus and 387 SNPs that have been associated with risks of other cancers, by using genotype imputation data on 2,163 control participants and 3,885 (1,501 EA and 2,384 Barrett's esophagus) case patients from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study, and investigated effect modification by smoking history, body mass index (BMI), and reflux/heartburn.
  
  
  RESULTS
  After correcting for multiple testing, none of the tested 387 SNPs were statistically significantly associated with risk of EA or Barrett's esophagus. No evidence of effect modification by smoking, BMI, or reflux/heartburn was observed.
  
  
  CONCLUSIONS
  Genetic risk variants for common cancers identified from GWAS appear not to be associated with risks of EA or Barrett's esophagus.
  
  
  CONCLUSIONS
  To our knowledge, this is the first investigation of pleiotropic genetic associations with risks of EA and Barrett's esophagus.
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. leee@usc.edu.
authors.forename: Eunjung
authors.initials: E
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Stram
authors.affiliation: Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: Weronica E
authors.initials: WE
authors.lastname: Ek
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Lynn E
authors.initials: LE
authors.lastname: Onstad
authors.affiliation: Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: Stuart
authors.initials: S
authors.lastname: MacGregor
authors.affiliation: Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: Puya
authors.initials: P
authors.lastname: Gharahkhani
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Weimin
authors.initials: W
authors.lastname: Ye
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Division of Cancer Studies, King's College London, London, United Kingdom.
authors.forename: Jesper
authors.initials: J
authors.lastname: Lagergren
authors.affiliation: Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Shaheen
authors.affiliation: Centre for Public Health, Queen's University Belfast, United Kingdom.
authors.forename: Liam J
authors.initials: LJ
authors.lastname: Murray
authors.affiliation: Division of Epidemiology, University of Leeds, Leeds, United Kingdom.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Hardie
authors.affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Marilie D
authors.initials: MD
authors.lastname: Gammon
authors.affiliation: Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas.
authors.forename: Wong-Ho
authors.initials: WH
authors.lastname: Chow
authors.affiliation: Yale School of Public Health, Department of Chronic Disease Epidemiology, New Haven, Connecticut.
authors.forename: Harvey A
authors.initials: HA
authors.lastname: Risch
authors.affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, California. San Francisco Medical Center, Kaiser Permanente Northern California, San Francisco, California.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Corley
authors.affiliation: Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington.
authors.forename: David M
authors.initials: DM
authors.lastname: Levine
authors.affiliation: Cancer Control, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: David C
authors.initials: DC
authors.lastname: Whiteman
authors.affiliation: Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California.
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.affiliation: Department of Oncology, University of Sheffield Medical School, Sheffield, United Kingdom.
authors.forename: Nigel C
authors.initials: NC
authors.lastname: Bird
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Vaughan
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Anna H
authors.initials: AH
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D001471:Barrett Esophagus / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics*; D058685:Genetic Pleiotropy / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors