title: [Application Progress of CRISPR/Cas9 System for Gene Editing in Tumor Research].
abstract: TCRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR-associated nuclease 9) gene editing system is a new type of gene editing technology developed based on the immune mechanism of archaea resisting the invasion of exogenous nucleic acid. Compared with traditional gene editing system, CRISPR/Cas9 system is more efficient, easier operating, and less cytotoxic. Currently, CRISPR/Cas9 gene editing technology has been applied to many aspects of cancer research, including research on cancer genes, constructing animal tumor models, screening tumor resistance-associated and phenotypic-related genes and cancer gene therapy. In this review, the application of the CRISPR/Cas9 system in tumor research were introduced.
authors.affiliation: Harbin Medical University Cancer Hospital, Harbin 150081, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Harbin Medical University Cancer Hospital, Harbin 150081, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Li
authors.affiliation: Harbin Medical University Cancer Hospital, Harbin 150081, China.
authors.forename: Yanqiao
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D064113:CRISPR-Cas Systems; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy