title: Assessment of SiCaP-30 in a Rabbit Posterolateral Fusion Model with Concurrent Chemotherapy.
abstract: Chemotherapy derivatives of the rabbit posterolateral fusion model are considered a challenging environment in which to test bone graft materials. The purpose of this study was to determine the performance characteristics of SiCaP-30 as a bone graft substitute relative to autograft (iliac crest bone graft [ICBG]), Actifuse ABX and β-Tricalcium Phosphate-Bioactive Glass-Type I Collagen (βTCP-BG) in a rabbit posterolateral spine fusion model with concurrent chemotherapy treatment This was a randomized, controlled study in a laboratory setting with blinded assessment of fusion by manual palpation and flexibility testing. Sixty rabbits were entered into the study with 45 used for analysis. Chemotherapeutic agents, doxorubicin and cis-platin (2.5 mg/kg), were administered one week prior to surgery, and one, two and three weeks post surgery. Bilateral posterolateral lumbar intertransverse process fusions were performed at L5-L6. The lateral two thirds of the transverse processes were decorticated and covered with 3cc/side of one of the following graft materials: autologous ICBG, Actifuse ABX (ApaTech Ltd, UK), Vitoss BA (Orthovita, USA) or SiCaP-30 (ApaTech Ltd., UK). Animals were euthanized 12 weeks post surgery. The ICBG group had a 45% (5/11) manual palpation fusion rate and correlated with motion analysis fusion results of 36% (4/11). The Actifuse ABX group had a 33% (4/12) manual palpation fusion rate and a motion analysis fusion rate of 25% (3/12). No motion segments in the Vitoss BA group (0/11) showed any signs of fusion. The SiCaP-30 group demonstrated a statistically higher manual palpation and motion analysis fusion rate of 82% (9/11; p<0.05) and produced superior bone formation compared with Actifuse ABX and βTCP-BG.
authors.affiliation: The University of Iowa, Department of Orthopaedics and Rehabilitation , Iowa City, Iowa ; The Bone Healing Research Laboratory; The Iowa Spine Research Center.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Smucker
authors.affiliation: The University of Iowa, Department of Orthopaedics and Rehabilitation , Iowa City, Iowa ; The Bone Healing Research Laboratory; The Iowa Spine Research Center.
authors.forename: Emily B
authors.initials: EB
authors.lastname: Petersen
authors.affiliation: The University of Iowa, Department of Orthopaedics and Rehabilitation , Iowa City, Iowa ; The Bone Healing Research Laboratory; The Iowa Spine Research Center.
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Hili
authors.affiliation: The University of Iowa, Department of Orthopaedics and Rehabilitation , Iowa City, Iowa ; The Bone Healing Research Laboratory; The Iowa Spine Research Center.
authors.forename: James V
authors.initials: JV
authors.lastname: Nepola
authors.affiliation: The University of Iowa, Department of Orthopaedics and Rehabilitation , Iowa City, Iowa ; The Bone Healing Research Laboratory; The Iowa Spine Research Center.
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Fredericks
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015519:Bone Density / Q000502:physiology; D018786:Bone Substitutes; D002130:Calcium Phosphates; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D007262:Infusions, Intravenous; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D023421:Models, Animal; D016684:Prone Position; D011817:Rabbits; D011897:Random Allocation; D016059:Range of Motion, Articular / Q000502:physiology*; D017640:Silicates; D013123:Spinal Fusion / Q000009:adverse effects / Q000379:methods*; D013314:Stress, Mechanical; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D018786:Bone Substitutes; D002130:Calcium Phosphates; D017640:Silicates; C503149:Vitoss; D004317:Doxorubicin; D002945:Cisplatin
keywords: SiCaP-30; bone substitute; lumbar spine; posterolateral fusion; silicate-substitute