title: The TriGuard embolic deflection device for prevention of stroke and cerebral embolization during transcatheter aortic valve replacement.
abstract: The incidence of embolic ischemic cerebral events during transcatheter aortic valve implantation remains high. The effects range from clinically silent embolic lesions in the brain to severe disabling stroke. Memory loss and other functional neurocognitive impairment are a direct result of embolic strokes. The TriGuard embolic deflection device is a nitinol frame filter that is placed across all three aortic cerebral vessel ostia to prevent particles from entering the brain circulation during the procedure. The results of clinical studies suggest that this procedure can lead to a reduction of embolic events, and an improvement of neurocognitive function when compared with unprotected transcatheter aortic valve implantation.
authors.affiliation: a 1 Bristol Heart Institute, University Hospitals Bristol, Bristol , Royal Infirmary, Upper Maudlin St, Bristol, Avon BS2 8HW, UK.
authors.forename: Andreas
authors.initials: A
authors.lastname: Baumbach
authors.affiliation: b 2 Yale Cardiovascular Research Group , New Haven, CT, USA.
authors.forename: Cody
authors.initials: C
authors.lastname: Pietras
authors.affiliation: b 2 Yale Cardiovascular Research Group , New Haven, CT, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Lansky
mesh_terms: D002986:Clinical Trials as Topic; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006801:Humans; D020766:Intracranial Embolism / Q000517:prevention & control*; D020521:Stroke / Q000517:prevention & control*; D065467:Transcatheter Aortic Valve Replacement
keywords: embolic protection; stroke; transcatheter aortic valve implantation