title: In Vitro Evaluation of Hydroxyapatite-Coated Titanium Implant with Atmospheric Plasma Treatment.
abstract: Plasma treatments are becoming a popular method for modifying the characteristics of a range of substrate surfaces. Atmospheric pressure plasma (APP) is cost-efficient, safe and simple compared to high-pressure plasma. This study examined the effects of a low-temperature APP treatment of a hydroxyapatite (HA)-coated Ti (HA-Ti) surface. The APP treatment made the HA-Ti surfaces more hydrophilic without changing surface morphologies. The APP-treated HA-Ti (APP-HA-Ti) surface showed enhanced cell spreading, cell proliferation, and alkaline phosphatase (ALP) levels with more developed cellular networks, and the formed extracellular matrix (ECM) was fused perfectly with the HA substrate than that on the HA-Ti surface. In conclusion, an APP treatment is a potential surface-modifying method that can enhance the cell affinity at the early stages in vitro.
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Tae-Yub
authors.initials: TY
authors.lastname: Kwon
authors.forename: Kyo-Han
authors.initials: KH
authors.lastname: Kim
authors.forename: Seong Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Seok Hwa
authors.initials: SH
authors.lastname: Choi
authors.forename: Soon-Taek
authors.initials: ST
authors.lastname: Kwon
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Cho
authors.forename: Jun Sik
authors.initials: JS
authors.lastname: Son
mesh_terms: D000327:Adsorption; D000818:Animals; D001274:Atmospheric Pressure; D018786:Bone Substitutes / Q000138:chemical synthesis; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D049109:Cell Proliferation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis; D017886:Durapatite / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology; D010316:Particle Size; D058626:Plasma Gases / Q000737:chemistry*; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D058626:Plasma Gases; C009495:titanium dioxide; D017886:Durapatite; D014025:Titanium