title: Epidemiological features of influenza in Canadian adult intensive care unit patients.
abstract: To identify predictive factors and mortality of patients with influenza admitted to intensive care units (ICU) we carried out a prospective cohort study of patients hospitalized with laboratory-confirmed influenza in adult ICUs in a network of Canadian hospitals between 2006 and 2012. There were 626 influenza-positive patients admitted to ICUs over the six influenza seasons, representing 17·9% of hospitalized influenza patients, 3·1/10,000 hospital admissions. Variability occurred in admission rate and proportion of hospital influenza patients who were admitted to ICUs (proportion range by year: 11·7-29·4%; 21·3% in the 2009-2010 pandemic). In logistic regression models ICU patients were younger during the pandemic and post-pandemic period, and more likely to be obese than hospital non-ICU patients. Influenza B accounted for 14·2% of all ICU cases and had a similar ICU admission rate as influenza A. Influenza-related mortality was 17·8% in ICU patients compared to 2·0% in non-ICU patients.
authors.affiliation: University of Alberta Hospital,Edmonton,Alberta,Canada.
authors.forename: G
authors.initials: G
authors.lastname: Taylor
authors.affiliation: Public Health Agency of Canada,Centre for Communicable Diseases and Infection Control,Ottawa,Ontario,Canada.
authors.forename: K
authors.initials: K
authors.lastname: Abdesselam
authors.affiliation: Public Health Agency of Canada,Centre for Communicable Diseases and Infection Control,Ottawa,Ontario,Canada.
authors.forename: L
authors.initials: L
authors.lastname: Pelude
authors.affiliation: Public Health Agency of Canada,Centre for Communicable Diseases and Infection Control,Ottawa,Ontario,Canada.
authors.forename: R
authors.initials: R
authors.lastname: Fernandes
authors.affiliation: Public Health Agency of Canada,Centre for Communicable Diseases and Infection Control,Ottawa,Ontario,Canada.
authors.forename: R
authors.initials: R
authors.lastname: Mitchell
authors.affiliation: Mount Sinai Hospital,Toronto,Ontario,Canada.
authors.forename: A
authors.initials: A
authors.lastname: McGeer
authors.affiliation: McGill University Health Centre,Montreal,Quebec,Canada.
authors.forename: C
authors.initials: C
authors.lastname: Frenette
authors.affiliation: Ottawa Hospital,Ottawa,Ontario,Canada.
authors.forename: K N
authors.initials: KN
authors.lastname: Suh
authors.affiliation: Royal University Hospital,Saskatoon,Saskatchewan,Canada.
authors.forename: A
authors.initials: A
authors.lastname: Wong
authors.affiliation: North York General Hospital,Ontario,Canada.
authors.forename: K
authors.initials: K
authors.lastname: Katz
authors.affiliation: Public Health Agency of Canada,Centre for Communicable Diseases and Infection Control,Ottawa,Ontario,Canada.
authors.forename: K
authors.initials: K
authors.lastname: Wilkinson
authors.affiliation: Public Health Agency of Canada,Centre for Communicable Diseases and Infection Control,Ottawa,Ontario,Canada.
authors.forename: T
authors.initials: T
authors.lastname: Mersereau
authors.affiliation: Public Health Agency of Canada,Centre for Communicable Diseases and Infection Control,Ottawa,Ontario,Canada.
authors.forename: D
authors.initials: D
authors.lastname: Gravel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D058873:Pandemics; D011446:Prospective Studies; D055815:Young Adult
keywords: Critical care; epidemiology; hospital; influenza