title: Cortical thickness in adults with agenesis of the corpus callosum.
abstract: Agenesis of the corpus callosum (AgCC) is a congenital malformation that can occur in isolation or in association with other neurological conditions. Although the behavioral manifestations associated with AgCC have been widely studied, the effects of complete absence of the corpus callosum (CC) on cerebral cortex anatomy are still not completely understood. In this study, cortical thickness in adults with complete AgCC was compared to a group of healthy controls. Results showed highly variable patterns of cortical thickness in AgCC individuals, with few areas showing significant and consistent alterations including primary visual cortex, primary somatosensory cortex and primary motor cortex. These results suggest relatively limited effects of AgCC on cortical morphology, which are mostly restricted to primary sensory and motor areas.
authors.affiliation: Département de Psychologie, Université de Montréal, Canada; Research center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Canada.
authors.forename: Vincent
authors.initials: V
authors.lastname: Beaulé
authors.affiliation: Département de Psychologie, Université de Montréal, Canada; Research center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Canada.
authors.forename: Sara
authors.initials: S
authors.lastname: Tremblay
authors.affiliation: Département de Psychologie, Université de Montréal, Canada; Research center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Canada.
authors.forename: Louis-Philippe
authors.initials: LP
authors.lastname: Lafleur
authors.affiliation: Montreal Neurological Institute, McGill University, Montréal, QC, Canada.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Tremblay
authors.affiliation: Département de Psychologie, Université de Montréal, Canada; Research center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Canada.
authors.forename: Maryse
authors.initials: M
authors.lastname: Lassonde
authors.affiliation: Psychology, Université du Québec à Trois-Rivières, Trois-Rivières, Canada.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Lepage
authors.affiliation: Département de Psychologie, Université de Montréal, Canada; Research center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Canada. Electronic address: hugo.theoret@umontreal.ca.
authors.forename: Hugo
authors.initials: H
authors.lastname: Théoret
mesh_terms: D000328:Adult; D061085:Agenesis of Corpus Callosum / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D055815:Young Adult
keywords: Agenesis; Corpus callosum; Cortical thickness; Magnetic resonance imaging; Split-brain