title: Effect of free radical scavenger, edaravone, for patients with carbon monoxide poisoning.
abstract: OBJECTIVE
  Chronic neurological symptoms after carbon monoxide (CO) poisoning are caused by various biological processes in the damaged brain, with free radicals playing roles as mediators in establishing pathological processes leading to chronic neurological symptoms under CO poisoning. This study aimed to clarify the effects of a free radical scavenger, edaravone, in patients with CO poisoning.
  
  
  METHODS
  We retrospectively compared two groups comprising patients treated with hyperbaric oxygenation alone (Group A, n=25) or edaravone in addition to hyperbaric oxygenation (Group B, n=25). Edaravone was administrated intravenously at 30 mg every 12h for 7 days. Patient characteristics, general conditions on admission, and frequency of chronic neurological symptoms were compared between groups. Among patients showing chronic neurological symptoms, cognitive function and daily activity were also compared between groups.
  
  
  RESULTS
  No significant differences in characteristics or general conditions on admission were identified between groups. In Group B, no patients presented with marked complications caused by edaravone. Although chronic persisting symptoms were less frequent in Group B (n=1, 0.04%) than in Group A (n=5, 20%), this difference was not significant. In the 11 patients showing chronic symptoms, scores for cognitive function and daily activity in the chronic phase were better in Group B than in Group A, but no significant differences were apparent.
  
  
  CONCLUSIONS
  The present results suggest that edaravone represents a tolerable and feasible treatment for CO-poisoned patients. Further studies are needed to clarify whether edaravone can favorably influence chronic neurological symptoms caused by CO poisoning.
authors.affiliation: Iwate Prefectural Advanced Critical Care and Emergency Center, Morioka, Japan.
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Mori
authors.affiliation: Department of Neurosurgery, Iwate Medical University, Morioka, Japan; Division of Hyperbaric Medicine, Iwate Medical University, Morioka, Japan. Electronic address: tbeppu@iwate-med.ac.jp.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Beppu
authors.affiliation: Iwate Prefectural Advanced Critical Care and Emergency Center, Morioka, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Fujisawa
authors.affiliation: Iwate Prefectural Advanced Critical Care and Emergency Center, Morioka, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Onodera
authors.affiliation: Department of Neurosurgery, Iwate Medical University, Morioka, Japan.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ogasawara
authors.affiliation: Institute for Biomedical Sciences, Iwate Medical University, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.affiliation: Department of Radiology, Iwate Medical University, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ehara
authors.affiliation: Department of Psychiatry, Iwate Medical University, Morioka, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Sakai
authors.affiliation: Iwate Prefectural Advanced Critical Care and Emergency Center, Morioka, Japan.
authors.forename: Shigeatsu
authors.initials: S
authors.lastname: Endo
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002249:Carbon Monoxide Poisoning / Q000523:psychology / Q000628:therapy*; D016022:Case-Control Studies; D003071:Cognition; D003131:Combined Modality Therapy; D000077553:Edaravone; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine
keywords: Carbon monoxide poisoning; Demyelination; Edaravone; Free radical; Myelin basic protein