title: CD4+CD28null T cells in acute coronary syndrome: lower with ST-elevation myocardial infarction.
abstract: OBJECTIVE
  We explored any possible difference in the percentage of CD4 + CD28null T cells between patients with ST-segment-elevation myocardial infarction (STEMI) and those with non-ST-segment-elevation acute coronary syndrome.
  
  
  METHODS
  We enrolled 55 consecutive patients admitted with acute coronary syndrome, and 16 healthy control subjects. CD4 + CD28null T cell percentage was assayed by flow cytometry from blood samples withdrawn at the time of enrollment.
  
  
  RESULTS
  Mean age was 55.2 ± 10.8 years (69.1% males). Mean CD4 + CD28null T cell percentage was 5.9 ± 3.8% in the study cohort versus 0.8 ± 0.7% in controls (p < 0.001). Mean CD4 + CD28null T cell percentage was higher in patients presenting with non-ST-segment-elevation acute coronary syndrome versus those presenting with STEMI: 7.3 ± 4.1% versus 4.6 ± 3.1%, respectively (p = 0.008). Multivariable regression analysis identified the category of acute coronary syndrome as the only variable independently associated with CD4 + CD28null T cell percentage (p = 0.007).
  
  
  CONCLUSIONS
  In patients presenting with acute coronary syndrome, the CD4 + CD28null T cell percentage was higher in patients with non-ST-segment-elevation acute coronary syndrome versus those with STEMI. The category of acute coronary syndrome was the only variable independently associated with the CD4 + CD28null T cell percentage in multivariable regression analysis.
authors.affiliation: a Department of Medical Microbiology and Immunology , Faculty of Medicine, Ain Shams University , Cairo , Egypt.
authors.forename: Nehad M
authors.initials: NM
authors.lastname: Sayed
authors.affiliation: a Department of Medical Microbiology and Immunology , Faculty of Medicine, Ain Shams University , Cairo , Egypt.
authors.forename: Safaa M
authors.initials: SM
authors.lastname: Abdel-Rahman
authors.affiliation: b Cardiology Department, Faculty of Medicine , Ain Shams University , Cairo , Egypt.
authors.forename: Iman
authors.initials: I
authors.lastname: Esmat
authors.affiliation: b Cardiology Department, Faculty of Medicine , Ain Shams University , Cairo , Egypt.
authors.forename: Wail
authors.initials: W
authors.lastname: Nammas
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000276:immunology*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D018106:CD28 Antigens / Q000032:analysis*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000175:diagnosis / Q000276:immunology*; D010641:Phenotype; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D018106:CD28 Antigens
keywords: CD4+CD28null T cells; acute coronary syndrome; acute myocardial infarction