title: Quality-of-life outcomes following pelvic exenteration for primary rectal cancer.
abstract: BACKGROUND
  For patients with locally advanced tumours and contiguous organ involvement, pelvic exenteration (PE) can offer cure with relatively low mortality. The literature surrounding quality of life (QoL) in patients undergoing PE is limited. Furthermore, there are no matched comparisons of QoL between abdominoperineal resection (APR) and PE. The aim of this study was to compare differences in long-term QoL for patients with primary rectal cancer undergoing APR versus PE.
  
  
  METHODS
  All patients who underwent either APR or PE between January 2011 and December 2012 were identified. Patients were asked to complete the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire before surgery and 2 weeks afterwards. Subsequent questionnaires were requested at 3, 6, 12 and 24 months after operation.
  
  
  RESULTS
  A total of 110 patients were included in the study (54 APR, 56 PE). Median length of stay following operation was 11 (range 3-70) days for APR and 15 (7-84) days for PE. Patients undergoing PE experienced lower physical (mean score 42 versus 56; P = 0.010), role (20 versus 33; P = 0.047), emotional (57 versus 73; P = 0.010) and social (34 versus 52; P = 0.005) functional levels 2 weeks after surgery. Long-term dyspnoea and financial worries were experienced only after PE. Patients undergoing PE had a lower overall global health status at 2 weeks after operation (40 versus 53; P = 0.012). Levels were comparable between groups from 3 months after surgery.
  
  
  CONCLUSIONS
  QoL recovery following PE was equivalent to that after APR alone. Patients should not be denied exenterative surgery based on perceived poor QoL.
authors.affiliation: Swansea Pelvic Oncology Group, Abertawe Bro Morgannwg University Local Health Board, Swansea, UK.
authors.forename: R W
authors.initials: RW
authors.lastname: Radwan
authors.affiliation: Swansea Pelvic Oncology Group, Abertawe Bro Morgannwg University Local Health Board, Swansea, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Codd
authors.affiliation: Swansea Pelvic Oncology Group, Abertawe Bro Morgannwg University Local Health Board, Swansea, UK.
authors.forename: M
authors.initials: M
authors.lastname: Wright
authors.affiliation: Swansea Centre for Health Economics, Swansea University, Swansea, UK.
authors.forename: D
authors.initials: D
authors.lastname: Fitzsimmons
authors.affiliation: Swansea Pelvic Oncology Group, Abertawe Bro Morgannwg University Local Health Board, Swansea, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Evans
authors.affiliation: Swansea Pelvic Oncology Group, Abertawe Bro Morgannwg University Local Health Board, Swansea, UK.
authors.forename: M
authors.initials: M
authors.lastname: Davies
authors.affiliation: Swansea Pelvic Oncology Group, Abertawe Bro Morgannwg University Local Health Board, Swansea, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Harris
authors.affiliation: Swansea Pelvic Oncology Group, Abertawe Bro Morgannwg University Local Health Board, Swansea, UK.
authors.forename: J
authors.initials: J
authors.lastname: Beynon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017060:Patient Satisfaction; D010385:Pelvic Exenteration / Q000523:psychology*; D011184:Postoperative Period; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000523:psychology / Q000601:surgery*; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors