title: The metabolic effects of a commercially available chicken peri-peri (African bird's eye chilli) meal in overweight individuals.
abstract: A growing body of evidence suggests that capsaicin ingestion may lead to desirable metabolic outcomes; however, the results in humans are equivocal. Whether or not benefits may be gained from ingestion of capsaicin via a commercially available meal has not been determined. The objectives of this randomised, cross-over intervention study were to compare the 2 h postprandial effects of a standard commercially prepared meal containing chilli (HOT, 5·82 mg total capsaicinoids) with a similar meal with no chilli (CON, 25 kg/m2 and a waist circumference >94 cm (men) or 80 cm (women), were studied. Participants had normal glucose tolerance and were accustomed, but were not regular chilli eaters. A paired t test indicated that insulin AUC was smaller following the HOT meal (P=0·002). Similarly, there was a tendency for glucose AUC to be reduced following the HOT meal (P=0·056). No discernable effects of the HOT meal were observed on metabolic rate, core temperature, hs-CRP concentrations and endothelial-dependent microvascular reactivity. The results from this study indicate that a standard restaurant meal containing a relatively small dose of capsaicin delivered via African bird's eye chilli, which is currently available to the public, results in lower postprandial insulin concentrations in overweight individuals, compared with the same meal without chilli.
authors.affiliation: UCT/MRC Research Unit for Exercise Science and Sports Medicine,Department of Human Biology, Faculty of Health Sciences,University of Cape Town,7700 Cape Town,South Africa.
authors.forename: Jacolene
authors.initials: J
authors.lastname: Kroff
authors.affiliation: UCT/MRC Research Unit for Exercise Science and Sports Medicine,Department of Human Biology, Faculty of Health Sciences,University of Cape Town,7700 Cape Town,South Africa.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hume
authors.affiliation: UCT/MRC Research Unit for Exercise Science and Sports Medicine,Department of Human Biology, Faculty of Health Sciences,University of Cape Town,7700 Cape Town,South Africa.
authors.forename: Paula
authors.initials: P
authors.lastname: Pienaar
authors.affiliation: UCT/MRC Research Unit for Exercise Science and Sports Medicine,Department of Human Biology, Faculty of Health Sciences,University of Cape Town,7700 Cape Town,South Africa.
authors.forename: Ross
authors.initials: R
authors.lastname: Tucker
authors.affiliation: UCT/MRC Research Unit for Exercise Science and Sports Medicine,Department of Human Biology, Faculty of Health Sciences,University of Cape Town,7700 Cape Town,South Africa.
authors.forename: Estelle V
authors.initials: EV
authors.lastname: Lambert
authors.affiliation: UCT/MRC Research Unit for Exercise Science and Sports Medicine,Department of Human Biology, Faculty of Health Sciences,University of Cape Town,7700 Cape Town,South Africa.
authors.forename: Dale E
authors.initials: DE
authors.lastname: Rae
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D001831:Body Temperature / Q000187:drug effects; D002097:C-Reactive Protein / Q000032:analysis; D002211:Capsaicin / Q000008:administration & dosage*; D002212:Capsicum / Q000737:chemistry; D002645:Chickens; D018592:Cross-Over Studies; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D062407:Meals; D008460:Meat; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D050177:Overweight / Q000097:blood / Q000378:metabolism*; D019518:Postprandial Period
chemical_list: D001786:Blood Glucose; D007328:Insulin; D002097:C-Reactive Protein; D002211:Capsaicin
keywords:  ACh acetylcholine;  CON control meal;  HOT intervention meal;  VR endothelial-dependent micro-vascular reactivity;  hs-CRP high sensitivity C-reactive protein; Capsaicin; Insulin responses; Postprandial glucose