title: Prenylated phenylpropanoid compounds from the stem bark of Illicium burmanicum.
abstract: Ten new prenylated phenylpropanoid compounds, burmanicumols A-G (1-6) and illifrognones D-G (7-10), and seven known prenylated phenylpropanoid compounds, were isolated from the stem bark of Illicium burmanicum. The structures of the new compounds were determined on the basis of 1D and 2D NMR, HRESIMS, and CD experiments. Compounds 3, 8, 10, and 14 were moderately potent inhibitors of the NF-κB pathway, with IC50 values ranging from 10.31 to 35.16μg/mL tripterygium glycosides and pavlin were used as the positive controls.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
authors.forename: Doudou
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Cell Biology, Second Military Medical University, Shanghai 200433, People's Republic of China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Changzheng Hospital, Second Military Medical University, Shanghai 200003, People's Republic of China.
authors.forename: Wansheng
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xue
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China. Electronic address: sssnmr@163.com.
authors.forename: Lianna
authors.initials: L
authors.lastname: Sun
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification; D052117:Benzodioxoles / Q000737:chemistry / Q000302:isolation & purification; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification; D057809:HEK293 Cells; D006801:Humans; D029523:Illicium / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D064209:Phytochemicals / Q000737:chemistry* / Q000302:isolation & purification; D024301:Plant Bark / Q000737:chemistry*; D054876:Prenylation
chemical_list: D000893:Anti-Inflammatory Agents; D052117:Benzodioxoles; D001572:Benzofurans; D001578:Benzopyrans; D016328:NF-kappa B; D064209:Phytochemicals
keywords: Illicium burmanicum; NF-κB; Prenylated phenylpropanoid compounds; Stem bark