title: Why and how have drug discovery strategies in pharma changed? What are the new mindsets?
abstract: In the pharmaceutical industry the long-term challenge of drug innovation is the key phrase throughout R&D that refers to increasing the output of original drug candidate molecules. To increase R&D productivity, implementation of new and strategic R&D orientations to develop new approaches or systems to identify hits and leads efficiently has taken place and enabled all scientists working in the drug discovery domain to develop innovative medicines for the 21st century.
authors.affiliation: Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, rue des Saints Peres, 75006, Paris, France. Electronic address: serge.mignani@parisdescartes.fr.
authors.forename: Serge
authors.initials: S
authors.lastname: Mignani
authors.affiliation: SCYNEXIS Inc., P.O. Box 12878, Research Triangle Park, NC 27709, USA.
authors.forename: Scot
authors.initials: S
authors.lastname: Huber
authors.affiliation: CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus Universitário da Penteada, 9000-390 Funchal, Portugal.
authors.forename: Helena
authors.initials: H
authors.lastname: Tomás
authors.affiliation: CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus Universitário da Penteada, 9000-390 Funchal, Portugal. Electronic address: joaor@uma.pt.
authors.forename: João
authors.initials: J
authors.lastname: Rodrigues
authors.affiliation: Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France; Université de Toulouse, UPS, INPT, 31077 Toulouse Cedex 4, France. Electronic address: majoral@lcc-toulouse.fr.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Majoral
mesh_terms: D035843:Biomedical Research / Q000639:trends; D055808:Drug Discovery / Q000639:trends*; D004345:Drug Industry / Q000639:trends*; D006801:Humans; D010604:Pharmacy; D014495:Universities