title: Regeneration of Full-Thickness Rotator Cuff Tendon Tear After Ultrasound-Guided Injection With Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Rabbit Model.
abstract: Rotator cuff tendon tear is one of the most common causes of chronic shoulder pain and disability. In this study, we investigated the therapeutic effects of ultrasound-guided human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection to regenerate a full-thickness subscapularis tendon tear in a rabbit model by evaluating the gross morphology and histology of the injected tendon and motion analysis of the rabbit's activity. At 4 weeks after ultrasound-guided UCB-derived MSC injection, 7 of the 10 full-thickness subscapularis tendon tears were only partial-thickness tears, and 3 remained full-thickness tendon tears. The tendon tear size and walking capacity at 4 weeks after UCB-derived MSC injection under ultrasound guidance were significantly improved compared with the same parameters immediately after tendon tear. UCB-derived MSC injection under ultrasound guidance without surgical repair or bioscaffold resulted in the partial healing of full-thickness rotator cuff tendon tears in a rabbit model. Histology revealed that UCB-derived MSCs induced regeneration of rotator cuff tendon tear and that the regenerated tissue was predominantly composed of type I collagens. In this study, ultrasound-guided injection of human UCB-derived MSCs contributed to regeneration of the full-thickness rotator cuff tendon tear without surgical repair. The results demonstrate the effectiveness of local injection of MSCs into the rotator cuff tendon.
  
  
  CONCLUSIONS
  The results of this study suggest that ultrasound-guided umbilical cord blood-derived mesenchymal stem cell injection may be a useful conservative treatment for full-thickness rotator cuff tendon tear repair.
authors.affiliation: Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
authors.forename: Gi-Young
authors.initials: GY
authors.lastname: Park
authors.affiliation: Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea coolkwon@cu.ac.kr dongrakkwon@hotmail.com.
authors.forename: Dong Rak
authors.initials: DR
authors.lastname: Kwon
authors.affiliation: Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Lee
mesh_terms: D000818:Animals; D036101:Cord Blood Stem Cell Transplantation; D004195:Disease Models, Animal; D064593:Heterografts; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D011817:Rabbits; D017006:Rotator Cuff; D013708:Tendon Injuries / Q000000981:diagnostic imaging / Q000628:therapy*; D014463:Ultrasonography
keywords: Injection; Mesenchymal stem cells; Rotator cuff; Tendon; Ultrasound