title: Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET.
abstract: Heat-induced radiolabeling (HIR) yielded (89) Zr-Feraheme (FH) nanoparticles (NPs) that were used to determine NP pharmacokinetics (PK) by positron emission tomography (PET). Standard uptake values indicated a fast hepatic uptake that corresponded to blood clearance, and a second, slow uptake process by lymph nodes and spleen. By cytometry, NPs were internalized by circulating monocytes and monocytes in vitro. Using an IV injection of HIR (89) Zr-FH (rather than in vitro cell labeling), PET/PK provided a view of monocyte trafficking, a key component of the immune response.
authors.affiliation: Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (USA).
authors.forename: Marc D
authors.initials: MD
authors.lastname: Normandin
authors.affiliation: Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (USA).
authors.forename: Hushan
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (USA).
authors.forename: Moses Q
authors.initials: MQ
authors.lastname: Wilks
authors.affiliation: Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129 (USA).
authors.forename: Howard H
authors.initials: HH
authors.lastname: Chen
authors.affiliation: McGill University, Department of Bioengineering, 817 Sherbrook Street, Montreal, Quebec H3A 0C3 (Canada).
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Kinsella
authors.affiliation: School of Materials Science and Engineering, Chonnam National University, Gwangju, 500-75 (South Korea).
authors.forename: Hoonsung
authors.initials: H
authors.lastname: Cho
authors.affiliation: Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (USA).
authors.forename: Nicolas J
authors.initials: NJ
authors.lastname: Guehl
authors.affiliation: Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (USA).
authors.forename: Nader
authors.initials: N
authors.lastname: Absi-Halabi
authors.affiliation: Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (USA).
authors.forename: Seyed Mohammadreza
authors.initials: SM
authors.lastname: Hosseini
authors.affiliation: Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (USA).
authors.forename: Georges
authors.initials: G
authors.lastname: El Fakhri
authors.affiliation: Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129 (USA).
authors.forename: David E
authors.initials: DE
authors.lastname: Sosnovik
authors.affiliation: Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (USA). ljosephson@mgh.harvard.edu.|Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129 (USA). ljosephson@mgh.harvard.edu.
authors.forename: Lee
authors.initials: L
authors.lastname: Josephson
mesh_terms: D000818:Animals; D006358:Hot Temperature; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D009000:Monocytes / Q000166:cytology*; D049268:Positron-Emission Tomography; D011868:Radioisotopes / Q000737:chemistry / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D015040:Zirconium / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; D015040:Zirconium
keywords: heat-induced radiolabeling; imaging; monocyte trafficking; nanoparticles; pharmacokinetics; positron emission tomography