title: Bioprostethic mitral valve thrombosis due to oral contraceptive drug use and management with ultra-slow thrombolytic therapy.
abstract: Prosthetic valve thrombosis is a severe complication, which usually occurs in inadequately anticoagulated patients. Mechanical valve thrombosis is more common than bioprosthetic valve thrombosis (BVT). Oral contraceptive drugs are associated with increased risk of thromboembolism in women. The possible association between oral contraceptive drug use and BVT has never been reported before. We present a case of obstructive BVT occurring after the use of an oral contraceptive drug and successful management with ultra-slow thrombolytic therapy.
authors.affiliation: aDepartment of Cardiology, Kars Karakani State Hospital, Kars bDepartment of Cardiology, İskilip Atif Hoca State Hospital, Çorum cDepartment of Cardiology, Kosuyolu Kartal Heart Training and Research Hospital, Istanbul dDepartment of Cardiology, Evliya Çelebi Training and Research Hospital, Kütahya eDepartment of Cardiology, Gaziemir State Hospital, İzmir fDepartment of Cardiology, Kars Kafkas University, Faculty of Medicine, Kars gDivision of Health Sciences, Ardahan University, Ardahan, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Yesin
authors.forename: Macit
authors.initials: M
authors.lastname: Kalçik
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Gündüz
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Astarcioğlu
authors.forename: Mustafa Ozan
authors.initials: MO
authors.lastname: Gürsoy
authors.forename: Süleyman
authors.initials: S
authors.lastname: Karakoyun
authors.forename: Mehmet
authors.initials: M
authors.lastname: Özkan
mesh_terms: D000328:Adult; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve / Q000473:pathology / Q000601:surgery; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D003276:Contraceptives, Oral; D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator