title: Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders.
abstract: This review summarises genetic studies in which calcium channel genes have been connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and schizophrenia to autism spectrum disorders and intellectual impairment. Among many other genes, striking numbers of the calcium channel gene superfamily have been implicated in the aetiology of these diseases by various DNA analysis techniques. We will discuss how these relate to the known monogenic disorders associated with point mutations in calcium channels. We will then examine the functional evidence for a causative link between these mutations or single nucleotide polymorphisms and the disease processes. A major challenge for the future will be to translate the expanding psychiatric genetic findings into altered physiological function, involvement in the wider pathology of the diseases, and what potential that provides for personalised and stratified treatment options for patients.
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
authors.forename: Samuel
authors.initials: S
authors.lastname: Heyes
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
authors.forename: Wendy S
authors.initials: WS
authors.lastname: Pratt
authors.affiliation: Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, UK.
authors.forename: Elliott
authors.initials: E
authors.lastname: Rees
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
authors.forename: Shehrazade
authors.initials: S
authors.lastname: Dahimene
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
authors.forename: Laurent
authors.initials: L
authors.lastname: Ferron
authors.affiliation: Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff CF24 4HQ, UK.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK. Electronic address: a.dolphin@ucl.ac.uk.
authors.forename: Annette C
authors.initials: AC
authors.lastname: Dolphin
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation; D009422:Nervous System Diseases / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide
chemical_list: D015220:Calcium Channels
keywords: Calcium channel; Mutation; Neuropsychiatric disorder; Polygenic disorder; Single nucleotide polymorphism