title: Eosinophilic pustular folliculitis associated with hematological disorders: A report of two cases and review of Japanese literature.
abstract: Eosinophilic pustular folliculitis (EPF) occurs in patients with hematological disorders. However, clinical information about hematological disorder-associated EPF is scarce. We report two cases of EPF associated with mantle cell lymphoma and reviewed the available published work on Japanese cases. We identified a total of 23 Japanese cases, including the two cases reported here, who had hematological disorder-associated EPF. Fourteen cases were associated with treatment for hematological malignancies (transplantation-related EPF) and nine cases were associated with hematological malignancies themselves (hematological malignancy-related EPF). Although the skin eruption was clinically indistinguishable between the two subtypes, transplantation-related EPF occurred on the face and trunk of young and middle-aged men and women, whereas hematological malignancy-related EPF occurred mostly on the face of older men. Peripheral blood eosinophilia was more frequently observed in transplantation-related EPF. These observations suggest variations among patients with EPF associated with hematological disorders.
authors.affiliation: Department of Dermatology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Takamura
authors.affiliation: Department of Dermatology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Teraki
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D015897:Comorbidity; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004802:Eosinophilia / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D005145:Face; D005260:Female; D005499:Folliculitis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D006402:Hematologic Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012737:Sex Factors; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D060726:Torso; D014750:Vincristine / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone; D007213:Indomethacin
keywords: bone marrow transplantation; eosinophilic pustular folliculitis; hematological disorder; hematological malignancy; immunosuppression; mantle cell lymphoma