title: Morphological Variants of Renal Carcinoma in Radical Nephrectomy Specimens.
abstract: OBJECTIVE
  To determine the morphological variants of Renal Cell Carcinoma (RCC) to detect the commonest histopathological type with special focus to the newly introduced entity Clear Cell Papillary Renal Cell Carcinoma (CCPRCC).
  
  
  METHODS
  Case series.
  
  
  METHODS
  Department of Pathology, Basic Medical Sciences Institute, JPMC, Karachi, from January 2007 to December 2012.
  
  
  METHODS
  Paraffin embedded blocks of 32 cases of radical nephrectomy specimens for renal mass were selected from records of Pathology Department, BMSI. Cases were excluded due to inadequate biopsies. Remaining 30 cases of renal cell carcinoma were included in study. H & E staining was done for all cases and PAS stain was employed for a few cases. All cases were reviewed under light microscope.
  
  
  RESULTS
  The 30 cases of renal cell carcinoma included 21 (70%) clear cell renal cell carcinoma, 03 (10%) clear cell papillary renal cell carcinoma, 02 (6.6%) papillary renal cell carcinoma and 04 (13.33%) hybrid tumors. Majority of cases (53.3%) found in age range between 40 - 60 years while 23.33% cases were found in 7th and 6.6% in 8th decade of life. While 16.66% cases were in younger age group that is between 31 - 40 years of age. Sixty percent cases of right radical nephrectomies and 40% cases of left radical nephrectomies.
  
  
  CONCLUSIONS
  CCRCC was most common histopathologic type followed by CCPRCC, hybrid tumors and PRCC.
authors.affiliation: Department of Pathology, Basic Medical Sciences Institute, JPMC, Karachi.
authors.lastname: Humera
authors.affiliation: Department of Urology, Basic Medical Sciences Institute, JPMC, Karachi.
authors.forename: Shahzad
authors.initials: S
authors.lastname: Ali
authors.affiliation: Department of Pathology, Basic Medical Sciences Institute, JPMC, Karachi.
authors.forename: Shahnaz Imdad
authors.initials: SI
authors.lastname: Kehar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002292:Carcinoma, Renal Cell / Q000145:classification / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009392:Nephrectomy; D010154:Pakistan; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor