title: Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses.
abstract: Differentiation of T cells is closely associated with dynamic changes in nutrient and energy metabolism. However, the extent to which specific metabolic pathways and molecular components are determinative of CD8+ T cell fate remains unclear. It has been previously established in various tissues that acetyl CoA carboxylase 2 (ACC2) regulates fatty acid oxidation (FAO) by inhibiting carnitine palmitoyltransferase 1 (CPT1), a rate-limiting enzyme of FAO in mitochondria. Here, we explore the cell-intrinsic role of ACC2 in T cell immunity in response to infections. We report here that ACC2 deficiency results in a marginal increase of cellular FAO in CD8+ T cells, but does not appear to influence antigen-specific effector and memory CD8+ T cell responses during infection with listeria or lymphocytic choriomeningitis virus. These results suggest that ACC2 is dispensable for CD8+ T cell responses.
authors.affiliation: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
authors.forename: Jang Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Walsh
authors.affiliation: Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia, 22908, United States of America.
authors.forename: Kyle L
authors.initials: KL
authors.lastname: Hoehn
authors.affiliation: Charles Perkins Centre Research and Education Hub, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: David E
authors.initials: DE
authors.lastname: James
authors.affiliation: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
authors.forename: E John
authors.initials: EJ
authors.lastname: Wherry
authors.affiliation: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
authors.forename: Yongwon
authors.initials: Y
authors.lastname: Choi
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000235:genetics / Q000276:immunology*; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D002334:Carnitine O-Palmitoyltransferase / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D005227:Fatty Acids / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007111:Immunity, Cellular; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000201:enzymology / Q000235:genetics / Q000276:immunology; D008216:Lymphocytic Choriomeningitis / Q000201:enzymology / Q000235:genetics / Q000276:immunology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics / Q000276:immunology*
chemical_list: D005227:Fatty Acids; D002334:Carnitine O-Palmitoyltransferase; C498191:Acacb protein, mouse; D000103:Acetyl-CoA Carboxylase