title: Effect of exposure routes on the relationships of lethal toxicity to rats from oral, intravenous, intraperitoneal and intramuscular routes.
abstract: The lethal toxicity values (log 1/LD(50)) of 527 aliphatic and aromatic compounds in oral, intravenous, intramuscular and intraperitoneal routes were used to investigate the relationships of log 1/LD(50) from different exposure routes. Regression analysis shows that the log 1/LD(50) values are well correlated between intravenous and intraperitoneal or intramuscular injections. However, the correlations between oral and intravenous or intraperitoneal routes are relatively poor. Comparison of the average residuals indicates that intravenous injection is the most sensitive exposure route and oral administration is the least sensitive exposure route. This is attributed to the difference in kinetic process of toxicity testing. The toxic effect of a chemical can be similar or significantly different between exposure routes, depending on the absorption rates of chemicals into blood. Inclusion of hydrophobic parameter and fractions of ionic forms can improve the correlations between intravenous and intraperitoneal or oral routes, but not between intraperitoneal and oral routes. This is due to the differences of absorption rate in different exposure environments from different routes. Several factors, such as experimental uncertainty, metabolism and toxic kinetics, can affect the correlations between intravenous and intraperitoneal or oral routes.
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Zhong H
authors.initials: ZH
authors.lastname: Ning
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Long
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Yuan Y
authors.initials: YY
authors.lastname: Zhou
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Zi Y
authors.initials: ZY
authors.lastname: Peng
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Yi N
authors.initials: YN
authors.lastname: Sun
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Si W
authors.initials: SW
authors.lastname: Chen
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China.
authors.forename: Li M
authors.initials: LM
authors.lastname: Su
authors.affiliation: State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR China. Electronic address: zhaoyh@nenu.edu.cn.
authors.forename: Yuan H
authors.initials: YH
authors.lastname: Zhao
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004333:Drug Administration Routes; D065569:Gastrointestinal Absorption / Q000187:drug effects* / Q000502:physiology; D057927:Hydrophobic and Hydrophilic Interactions; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D065586:Intramuscular Absorption / Q000187:drug effects* / Q000502:physiology; D007928:Lethal Dose 50; D008297:Male; D009930:Organic Chemicals / Q000008:administration & dosage* / Q000097:blood / Q000633:toxicity*; D065629:Peritoneal Absorption / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D023382:Toxicity Tests, Acute / Q000379:methods*
chemical_list: D009930:Organic Chemicals
keywords: Absorption rate; Acute toxicity; Correlation; Exposure route; Metabolism; Toxic kinetics