title: Efficacy of Steroid Pulse Therapy for Autoimmune Pancreatitis Type 1: A Retrospective Study.
abstract: Autoimmune pancreatitis (AIP) is treatable with steroids, but relapse is frequent. The efficacy of steroid pulse therapy has been shown for various autoimmune diseases, but has not become established therapy. In this study, we reviewed the efficacy of steroid pulse therapy in 24 subjects who were diagnosed with AIP type 1 at our hospital. Patient characteristics, time-course of serum IgG4, and the cumulative relapse-free survival rate were compared between patients who received oral steroid therapy (oral group) and those who were treated with steroid pulse therapy (pulse group). Serum IgG4 was reduced significantly after therapy in both groups and the 5-year cumulative relapse-free survival rates in the two groups did not differ significantly (oral group 46.9%, pulse group 77.8%). However, in a subset of cases with diffuse pancreatic swelling, this rate was significantly lower in the oral group (33.3% vs. 100.0%, p = 0.046). These results suggest that steroid pulse therapy is effective for prevention of relapse in AIP patients with diffuse pancreatic swelling.
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sugimoto
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Takagi
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Rei
authors.initials: R
authors.lastname: Suzuki
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Konno
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Ko
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kikuchi
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Waragai
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Asama
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Takasumi
authors.affiliation: Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
authors.forename: Takuto
authors.initials: T
authors.lastname: Hikichi
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.affiliation: Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Obara
authors.affiliation: Department of Gastroenterology and Rheumatology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D018572:Disease-Free Survival; D004334:Drug Administration Schedule; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G; D011239:Prednisolone; D008775:Methylprednisolone