title: Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study.
abstract: Mild cognitive impairment (MCI) is a high-risk condition for progression to Alzheimer's disease (AD). Vascular health is a key mechanism underlying age-related cognitive decline and neurodegeneration. AD-related genetic risk factors may be associated with preclinical cognitive status changes. We examine independent and cross-domain interactive effects of vascular and genetic markers for predicting MCI status and stability.
  
  
  
  We used cross-sectional and 2-wave longitudinal data from the Victoria Longitudinal Study, including indicators of vascular health (e.g., reported vascular diseases, measured lung capacity and pulse rate) and genetic risk factors-that is, apolipoprotein E (APOE; rs429358 and rs7412; the presence vs absence of ε4) and catechol-O-methyltransferase (COMT; rs4680; met/met vs val/val). We examined associations with objectively classified (a) cognitive status at baseline (not impaired congnitive (NIC) controls vs MCI) and (b) stability or transition of cognitive status across a 4-year interval (stable NIC-NIC vs chronic MCI-MCI or transitional NIC-MCI).
  
  
  
  Using logistic regression, indicators of vascular health, both independently and interactively with APOE ε4, were associated with risk of MCI at baseline and/or associated with MCI conversion or MCI stability over the retest interval.
  
  
  
  Several vascular health markers of aging predict MCI risk. Interactively, APOE ε4 may intensify the vascular health risk for MCI.
authors.affiliation: Department of Psychology, University of Victoria, British Columbia, Canada. decarloc@uvic.ca.
authors.forename: Correne A
authors.initials: CA
authors.lastname: DeCarlo
authors.affiliation: Department of Psychology, University of Victoria, British Columbia, Canada.
authors.forename: Stuart W S
authors.initials: SW
authors.lastname: MacDonald
authors.affiliation: Campus St. Jean.
authors.forename: David
authors.initials: D
authors.lastname: Vergote
authors.affiliation: Department of Medicine (Neurology).|Neuroscience and Mental Health Institute.
authors.forename: Jack
authors.initials: J
authors.lastname: Jhamandas
authors.affiliation: Neuroscience and Mental Health Institute.|Centre for Prions and Protein Folding Diseases.
authors.forename: David
authors.initials: D
authors.lastname: Westaway
authors.affiliation: Neuroscience and Mental Health Institute.|Department of Psychology, University of Alberta, Edmonton, Canada.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Dixon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000502:physiology*; D053327:Apolipoprotein E4 / Q000235:genetics*; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics; D002394:Catechol O-Methyltransferase; D060825:Cognitive Dysfunction / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D014109:Total Lung Capacity / Q000502:physiology; D014739:Victoria / Q000453:epidemiology
chemical_list: D053327:Apolipoprotein E4; D015415:Biomarkers; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: 
  APOE
  ; 
  COMT
  ; Mild cognitive impairment; Vascular health; Victoria Longitudinal Study