title: Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy.
abstract: Our aim was to determine whether placental A Disintegrin-like Metalloproteinase with ThromboSpondin motif 12 (ADAMTS-12), arylesterase (ARES) levels, total oxidant status (TOS), and total antioxidant status (TAS) differ in preeclampsia, intrahepatic cholestasis of pregnancy (ICP), and uncomplicated pregnancies or not. A prospective case-control study was carried out including 84 pregnant women (26 with ICP, 28 preeclamptic patients, and 30 healthy controls). Levels of ADAMTS-12, TAS, TOS, and ARES were studied in the supernatants of placental tissue homogenates. Placental ADAMTS-12 levels were distributed as 240.9 pg/mg in ICP, 289.7 pg/mg in preeclampsia, and 310.8 pg/mg in control groups. Levels of ADAMTS-12 (odds ratio = 6.509, 95% confidence interval:1.070-39.592, P = .042) in the placenta of the ICP were significantly lower than those in preeclampsia and control groups (P = .004), but no statistical significant difference was determined between preeclampsia and control groups. Decreased levels of placental ADAMTS-12 were found to be associated with ICP, suggesting a possible role of inflammation in the pathogenesis.
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey efseroztas@gmail.com.
authors.forename: Efser
authors.initials: E
authors.lastname: Oztas
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Ozler
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Ali O
authors.initials: AO
authors.lastname: Ersoy
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Kudret
authors.initials: K
authors.lastname: Erkenekli
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Sucak
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Ergin
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D000071096:ADAMTS Proteins / Q000378:metabolism*; D000328:Adult; D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000378:metabolism*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000071096:ADAMTS Proteins; C496252:ADAMTS12 protein, human
keywords: ADAMTS-12; intrahepatic cholestasis of pregnancy; preeclampsia