title: Conservation of Planar Polarity Pathway Function Across the Animal Kingdom.
abstract: Planar polarity is a well-studied phenomenon resulting in the directional coordination of cells in the plane of a tissue. In invertebrates and vertebrates, planar polarity is established and maintained by the largely independent core and Fat/Dachsous/Four-jointed (Ft-Ds-Fj) pathways. Loss of function of these pathways can result in a wide range of developmental or cellular defects, including failure of gastrulation and problems with placement and function of cilia. This review discusses the conservation of these pathways across the animal kingdom. The lack of vital core pathway components in basal metazoans suggests that the core planar polarity pathway evolved shortly after, but not necessarily alongside, the emergence of multicellularity.
authors.affiliation: Bateson Centre.|Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom; email: d.strutt@sheffield.ac.uk.
authors.forename: Rosalind
authors.initials: R
authors.lastname: Hale
authors.affiliation: Bateson Centre.|Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom; email: d.strutt@sheffield.ac.uk.
authors.forename: David
authors.initials: D
authors.lastname: Strutt
mesh_terms: D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning / Q000502:physiology; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D016764:Cell Polarity / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014714:Vertebrates / Q000378:metabolism
chemical_list: D015820:Cadherins; D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; C094449:ds protein, Drosophila; C472307:ft protein, Drosophila
keywords: PCP; animals; invertebrates; planar polarity; vertebrates