title: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository: Structural and functional MRI, MEG, and cognitive data from a cross-sectional adult lifespan sample.
abstract: This paper describes the data repository for the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) initial study cohort. The Cam-CAN Stage 2 repository contains multi-modal (MRI, MEG, and cognitive-behavioural) data from a large (approximately N=700), cross-sectional adult lifespan (18-87years old) population-based sample. The study is designed to characterise age-related changes in cognition and brain structure and function, and to uncover the neurocognitive mechanisms that support healthy cognitive ageing. The database contains raw and preprocessed structural MRI, functional MRI (active tasks and resting state), and MEG data (active tasks and resting state), as well as derived scores from cognitive behavioural experiments spanning five broad domains (attention, emotion, action, language, and memory), and demographic and neuropsychological data. The dataset thus provides a depth of neurocognitive phenotyping that is currently unparalleled, enabling integrative analyses of age-related changes in brain structure, brain function, and cognition, and providing a testbed for novel analyses of multi-modal neuroimaging data.
authors.affiliation: School of Psychological Sciences, The University of Manchester, Zochonis Building, Brunswick Street, Manchester M13 9PL, UK. Electronic address: jason.taylor@manchester.ac.uk.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Taylor
authors.affiliation: MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK. Electronic address: nitin.williams@mrc-cbu.cam.ac.uk.
authors.forename: Nitin
authors.initials: N
authors.lastname: Williams
authors.affiliation: Brain and Mind Institute, University of Western Ontario, London, ON, Canada. Electronic address: rhodri@cusacklab.org.
authors.forename: Rhodri
authors.initials: R
authors.lastname: Cusack
authors.affiliation: MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK. Electronic address: tibor.auer@mrc-cbu.cam.ac.uk.
authors.forename: Tibor
authors.initials: T
authors.lastname: Auer
authors.affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK. Electronic address: mshafto@csl.psychol.cam.ac.uk.
authors.forename: Meredith A
authors.initials: MA
authors.lastname: Shafto
authors.affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK. Electronic address: admin@cam-can.com.
authors.forename: Marie
authors.initials: M
authors.lastname: Dixon
authors.affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK. Electronic address: lktyler@csl.psychol.cam.ac.uk.
authors.forename: Lorraine K
authors.initials: LK
authors.lastname: Tyler
authors.affiliation: Cambridge Centre for Ageing and Neuroscience (Cam-CAN), University of Cambridge and MRC Cognition and Brain Sciences Unit, Cambridge, UK. Electronic address: http://www.cam-can.com.
authors.lastname: Cam-Can
authors.affiliation: MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK. Electronic address: rik.henson@mrc-cbu.cam.ac.uk.
authors.forename: Richard N
authors.initials: RN
authors.lastname: Henson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D005260:Female; D059907:Functional Neuroimaging / Q000706:statistics & numerical data*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D015225:Magnetoencephalography / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009488:Neurosciences / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Ageing; Brain imaging; Cognition; Data repository; Magnetic resonance imaging; Magnetoencephalography