title: Febuxostat-associated drug reaction with eosinophilia and systemic symptoms (DRESS).
abstract: OBJECTIVE
  Febuxostat is recommended as an alternative drug for gouty patients with a history of allopurinol hypersensitivity or carrying the HLA-B*5801 allele.
  
  
  METHODS
  An 81-year-old man with the medical history of gout presented to our clinic with generalized rashes for 2 days. After taking febuxostat for 2 days, he developed generalized skin rash with high fever. Laboratory tests showed elevated liver enzymes and acute kidney injury.
  
  
  OBJECTIVE
  This is the first identified case of febuxostat-associated DRESS. Febuxostat should be withdrawn immediately when DRESS is observed to avoid further serious complications.
authors.affiliation: Clinical Pharmacy Division, Department of Pharmacy, Chang Gung Memorial Hospital, Linkou, Taiwan.
authors.forename: H-Y
authors.initials: HY
authors.lastname: Chou
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan.|Chang Gung University College of Medicine, Taoyuan, Taiwan.
authors.forename: C-B
authors.initials: CB
authors.lastname: Chen
authors.affiliation: Clinical Pharmacy Division, Department of Pharmacy, Chang Gung Memorial Hospital, Linkou, Taiwan.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
authors.forename: Y-A
authors.initials: YA
authors.lastname: Chen
authors.affiliation: Chang Gung University College of Medicine, Taoyuan, Taiwan.|Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: C Y
authors.initials: CY
authors.lastname: Ng
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan.|Chang Gung University College of Medicine, Taoyuan, Taiwan.
authors.forename: K-L
authors.initials: KL
authors.lastname: Kuo
authors.affiliation: Clinical Pharmacy Division, Department of Pharmacy, Chang Gung Memorial Hospital, Linkou, Taiwan.
authors.forename: W-L
authors.initials: WL
authors.lastname: Chen
authors.affiliation: Clinical Pharmacy Division, Department of Pharmacy, Chang Gung Memorial Hospital, Linkou, Taiwan.
authors.forename: C-H
authors.initials: CH
authors.lastname: Chen
mesh_terms: D000369:Aged, 80 and over; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D000069465:Febuxostat / Q000009:adverse effects* / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy; D006801:Humans; D008297:Male
chemical_list: D000069465:Febuxostat
keywords: Febuxostat; adverse drug reaction; drug reaction with eosinophilia and systemic symptoms