title: Development and Evaluation of Nanoemulsions Containing Phthalocyanines for Use in Photodynamic Cancer Therapy.
abstract: This work reports the development of oil in water (o/w) nanoemulsions containing poly(ethylene oxide)-poly(propylene oxide) block copolymer surfactant for the formulation of a delivery system for endovenous zinc and chloroaluminum phthalocyanines. A solubility study suggested clove oil and its combination with ethanol as the best candidates for the oil phase composition. The nanoemulsions were obtained using a high-pressure homogenizer and analyzed for droplet size to determine their short- and long-term stability. Formulations containing 7 and 10% oil phase and 12% surfactant presented higher stability and allowed the incorporation of a bigger amount of phthalocyanines in the formulation. Rheological analyses showed the prevailing Newtonian behavior of the nanoemulsions. Studies of toxicity and phototoxicity determined that the nanoemulsions produced were capable of inhibiting the growth of adenocarcinoma tumor cells. The nanoemulsions proved to be a good alternative for use in photodynamic therapy.
authors.forename: Juliana P
authors.initials: JP
authors.lastname: Senna
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ricci-Júnior
authors.forename: Claudia R E
authors.initials: CR
authors.lastname: Mansur
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D045783:Clove Oil; D004655:Emulsions / Q000737:chemistry* / Q000633:toxicity; D000431:Ethanol; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000633:toxicity; D054833:Isoindoles; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D012995:Solubility; D013501:Surface-Active Agents
chemical_list: D000970:Antineoplastic Agents; D045783:Clove Oil; D004655:Emulsions; D007211:Indoles; D054833:Isoindoles; D013501:Surface-Active Agents; D000431:Ethanol; C013647:phthalocyanine