title: Study of association of CTLA4 gene variants to non-anterior uveitis.
abstract: This study was undertaken to investigate the possible genetic association of functional CTLA4 polymorphisms with susceptibility to non-anterior uveitis. Four hundred and seventeen patients with endogenous non-anterior uveitis and 1517 healthy controls of Spanish Caucasian origin were genotyped for the CTLA4 polymorphisms rs733618, rs5742909 and rs231775, using predesigned TaqMan(©) allele discrimination assays. PLINK software was used for the statistical analyses. No significant associations between the CTLA4 polymorphisms and susceptibility to global non-anterior uveitis were found. It was also the case when the potential association of these genetic variants with the anatomical localization of the disease, such as intermediate, posterior or panuveitis, was assessed. Our results do not support a relevant role of these CTLA4 polymorphisms in the non-anterior uveitis genetic predisposition.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, P.T.S, Granada, Spain.
authors.forename: D A
authors.initials: DA
authors.lastname: Leon Rodriguez
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, P.T.S, Granada, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Serrano Lopera
authors.affiliation: Ophthalmology Department, Hospital de León, IBIOMED, Universidad de León, León, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Cordero-Coma
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, P.T.S, Granada, Spain.|Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Márquez
authors.affiliation: Ophthalmology Department, BioCruces Health Research Institute, Hospital Universitario Cruces, Barakaldo, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fonollosa
authors.affiliation: Autoimmune Diseases Research Unit, Internal Medicine Department, BioCruces Health Research Institute, Hospital Universitario Cruces, Barakaldo, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Ruiz-Arruza
authors.affiliation: Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Callejas
authors.affiliation: Ophthalmology Department, Hospital Clínico San Cecilio, Granada, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: García Serrano
authors.affiliation: Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Díaz Valle
authors.affiliation: Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Pato
authors.affiliation: Ophthalmology Department, Hospital Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Cañal
authors.affiliation: Ophthalmology Department, Hospital Carlos Haya, Málaga, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: del Rio
authors.affiliation: Institut Universitari Barraquer, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Capella
authors.affiliation: Ophthalmology Department, Hospital Donostia, San Sebastián, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Blanco
authors.affiliation: Ophthalmology Department, Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Olea
authors.affiliation: Ophthalmology Department, Hospital Universitario Rio Hortega, Valladolid, Spain.
authors.forename: Y
authors.initials: Y
authors.lastname: Cordero
authors.affiliation: Immunology Department, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Martín-Villa
authors.affiliation: Ophthalmology Department, Hospital Universitario Principe de Asturias, Alcalá de Henares, Spain.
authors.forename: M B
authors.initials: MB
authors.lastname: Gorroño-Echebarría
authors.affiliation: Ophthalmology Department, Hospital Clinic, Barcelona, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Molins
authors.affiliation: Ophthalmology Department, Hospital Clinic, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Adán
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, P.T.S, Granada, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Martin
mesh_terms: D000328:Adult; D060908:CTLA-4 Antigen; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D013030:Spain; D014605:Uveitis / Q000235:genetics*; D044465:White People
chemical_list: D060908:CTLA-4 Antigen
keywords: CTLA4; rs5742909 and rs231775; rs733618; single nucleotide polymorphisms; uveitis