title: Kidney donation after circulatory death: current evidence and opportunities for pediatric recipients.
abstract: Organ donation after circulatory death (DCD) has experienced a revival worldwide over the past 20 years, and is now widely practiced for kidney transplantation. Some previous concerns about these organs such as the high incidence of delayed graft function have been alleviated through evidence from adult studies. There are now a number of large adult cohorts reporting favorable 5-year outcomes for DCD kidney transplants, comparable to kidneys donated after brain death (DBD). This has resulted in a marked increase in the use of DCD kidneys for adult recipients in some countries and an increase in the overall number of kidney transplants. In contrast, the uptake of DCD kidneys for pediatric recipients is still low and concerns still exist over the longer-term outcomes of DCD organs. In view of the data from adult practice and the poor outcomes for children who stay on dialysis, DCD kidney transplantation should be offered as an option for children on the kidney transplant waiting list.
authors.affiliation: Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.
authors.forename: Matko
authors.initials: M
authors.lastname: Marlais
authors.affiliation: Department of Nephrology and Transplantation, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Callaghan
authors.affiliation: Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK. stephen.marks@gosh.nhs.uk.|Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK. stephen.marks@gosh.nhs.uk.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Marks
mesh_terms: D002648:Child; D046148:Donor Selection / Q000379:methods*; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D010372:Pediatrics / Q000379:methods*; D009927:Tissue and Organ Procurement / Q000379:methods*
keywords: Donation after circulatory death; Pediatrics; Renal transplantation