title: [New international reference values for spirometry: implications for clinical issues using a comparative analysis of a paediatric population].
abstract: BACKGROUND
  The new lung function reference values of the global lung initiative (GLI) are recommended by most health societies. The aim of this study was to analyze FEV1- and FEV1/FVC-values from a German and Austrian patient group applying old and new reference values.
  
  
  RESULTS
  A total of 215 Caucasian children (aged 5-17 years) were included. FEV1-values were significantly lower applying GLI reference values compared to Zapletal values (median 96.9 % pred. (87.3-105.2) versus 100.6 % pred. (quartile 91.5-111.4), p = 0.000), the median difference was 4.9 % (range -12.9 to 27.5) % pred. Differences correlated significantly with age and FEV1 in % predicted (Zapletal), p = 0.000 17/70 (24 %) patients with cystic fibrosis had FEV1-values <80% pred. applying Zapletal, in 25 (36 %) patients FEV1 was abnormal (z-score <1645) using GLI values; 3/145 asthmatics (2 %) had FEV1-Werte <80 % d.S. (Zapletal), 7/145 (5 %) z-scores <1645 (GLI).
  
  
  CONCLUSIONS
  Differences between GLI-and Zapletal-reference values were considerable in pediatric asthma and CF-patients.
authors.affiliation: Klinik für Pädiatrische Kardiologie und Intensivmedizin, Schwerpunkt Kinderpneumologie/-allergologie, Universitätsmedizin, Robert-Koch-Strasse 40, Göttingen, Deutschland. christiane.lex@med.uni-goettingen.de.|Universitätsklinik und Poliklinik für Kinderheilkunde und Jugendmedizin, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland. christiane.lex@med.uni-goettingen.de.
authors.forename: Christiane
authors.initials: C
authors.lastname: Lex
authors.affiliation: Universitätsklinik und Poliklinik für Kinderheilkunde und Jugendmedizin, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland.
authors.forename: Insa
authors.initials: I
authors.lastname: Korten
authors.affiliation: Universitätsklinik und Poliklinik für Kinderheilkunde und Jugendmedizin, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hofmann
authors.affiliation: Universitätsklinik für Kinder und Jugendheilkunde, Medizinische Universität Wien, Wien, Österreich.
authors.forename: Sabine
authors.initials: S
authors.lastname: Renner
authors.affiliation: Universitätsklinik für Kinder und Jugendheilkunde, Medizinische Universität Wien, Wien, Österreich.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Szepfalusi
authors.affiliation: Wilhelminenspital Wien, Wien, Österreich.
authors.forename: Thomas
authors.initials: T
authors.lastname: Frischer
authors.affiliation: Wilhelminenspital Wien, Wien, Österreich.
authors.forename: Angela
authors.initials: A
authors.lastname: Zacharasiewicz
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis; D001317:Austria; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000175:diagnosis; D005260:Female; D005541:Forced Expiratory Volume; D005858:Germany; D006801:Humans; D038622:Internationality; D008297:Male; D012016:Reference Values; D013147:Spirometry / Q000592:standards*; D013223:Statistics as Topic; D014797:Vital Capacity
keywords: GLI; asthma; cystic fibrosis; lung function; reference values