title: Non-Proteinuric Diabetic Nephropathy.
abstract: Diabetic nephropathy patients traditionally show significant macroalbuminuria prior to the development of renal impairment. However, this clinical paradigm has recently been questioned. Epidemiological surveys confirm that chronic kidney disease (CKD) diagnosed by a low glomerular filtration rate (GFR) is more common in diabetic patients than in the non-diabetic population but a low number of patients had levels of proteinuria above that which traditionally defines overt diabetic nephropathy (>500 mg/g). The large number of patients with low levels of proteinuria suggests that the traditional clinical paradigm of overt diabetic nephropathy is changing since it does not seem to be the underlying renal lesion in most of diabetic subjects with CKD.
authors.affiliation: Cátedra de Riesgo Vascular, Facultad de Medicina, Universidad de Salamanca, Salamanca 37007, Spain. nrrobles@yahoo.es.
authors.forename: Nicolas Roberto
authors.initials: NR
authors.lastname: Robles
authors.affiliation: Servicio de Nefrologia, Hospital Infanta Cristina, Badajoz 06070, Spain. jvilla_19@hotmail.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Villa
authors.affiliation: Servicio de Nefrologia, Hospital Infanta Cristina, Badajoz 06070, Spain. romanhg78@hotmail.com.
authors.forename: Roman Hernandez
authors.initials: RH
authors.lastname: Gallego
keywords: chronic kidney disease; diabetes mellitus; microalbuminuria; proteinuria