title: Palladium-catalyzed enantioselective 1,1-fluoroarylation of aminoalkenes.
abstract: The development of an enantioselective palladium-catalyzed 1,1-fluoroarylation of unactivated aminoalkenes is described. The reaction uses arylboronic acids as the arene source and Selectfluor as the fluorine source to generate benzylic fluorides in good yields with excellent enantioselectivities. This transformation, likely proceeding through an oxidative Heck mechanism, affords 1,1-difunctionalized alkene products.
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720, United States.|Institute of Chemistry and BioMedical Science, Nanjing University , Nanjing 210046, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720, United States.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720, United States.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Thornbury
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720, United States.
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000588:Amines; D006845:Hydrocarbons, Fluorinated; D009942:Organometallic Compounds; D010165:Palladium