title: Cervical poorly differentiated adenocarcinoma with dominant choriocarcinomatous pattern--A case report.
abstract: BACKGROUND
  Gestational trophoblastic neoplasm (GTN), choriocarcinoma in coexistence with primary cervical adenocarcinoma, is a rare event not easy to diagnose. Choriocarcinoma is a malignant form of GTN but curable if metastases do not appear early and spread fast.
  
  
  METHODS
  We presented choriocarcinoma in coexistence with primary cervical adenocarcinoma in a 48-year-old patient who had radical hysterectomy because of confirmed cervical carcinoma (Dg: Carcinomaporo vaginalis uteri FIGO st I B1). Histological findings confirmed cervical choriocarcinoma with extensive vascular invasion and apoptosis but GTN choriocarcinoma was finally confirmed after immunohystochemical examinations. Preoperative serum human gonadotropine (beta hCG) level stayed unknown. This patient did not have any pregnancy-like symptoms before the operation. The first beta hCG monitoring was done two months after the operation and found negative. According to the final diagnosis the decision of Consilium for Malignant Diseases was that this patient needed serum hCG monitoring as well as treatment with chemotherapy for high-risk GTN and consequent irradiation for adenocarcinoma.
  
  
  CONCLUSIONS
  The early and proper diagnosis of nonmetastatic choriocarcinoma of nongestational origine in coexistence with cervical carcinoma is curable and can have good prognosis.
authors.forename: Branka
authors.initials: B
authors.lastname: Nikolić
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Ćurković
authors.forename: Svetlana Dragojević
authors.initials: SD
authors.lastname: Dikić
authors.forename: Ana
authors.initials: A
authors.lastname: Mitrović
authors.forename: Igor
authors.initials: I
authors.lastname: Kuzmanović
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Arandjelović
authors.forename: Goran
authors.initials: G
authors.lastname: Stanković
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002454:Cell Differentiation; D017024:Chemotherapy, Adjuvant; D002822:Choriocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor