title: Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia.
abstract: OBJECTIVE
  Pre-eclampsia is the result of impaired trophoblast invasion and spiral artery remodeling managed by inflammatory response in its etiology and physiopathology. The aim of this study was to compare serum molecules including IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels between pre-eclampsia and control groups and to investigate the role of these molecules in pre-eclampsia.
  
  
  METHODS
  Forty-one women diagnosed as pre-eclampsia between 30 and 40 weeks of gestation and 41 non-complicated pregnant women were enrolled in this cross-sectional, case-control prospective study. ELISA method was used to determine IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels within serums in two groups.
  
  
  RESULTS
  Serum ADAMTS12 and IL-33 levels were significantly lower in pre-eclampsia group (p < 0.001 and p: 0.028, respectively), however, in sub-group analysis, no significant difference was observed (p > 0.05). The cut-off value of ADAMTS12 levels to discriminate pre-eclampsia with %73.17 sensitivity and %92.68 specificity was 8.27 ng/ml while the cut-off value for IL-33 was 0.23 pg/ml with 82.93% sensitivity and 53.66% specificity.
  
  
  CONCLUSIONS
  Pre-eclampsia is associated with lower serum IL-33 and ADAMTS12 levels.
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: İrem
authors.initials: İ
authors.lastname: Eda Gökdemir
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Özdeğirmenci
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Burak
authors.initials: B
authors.lastname: Elmas
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .|b Department of Obstetrics and Gynecology , Yıldırım Beyazıt University School of Medicine , Ankara , Turkey .
authors.forename: Esma
authors.initials: E
authors.lastname: Sarikaya
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.affiliation: c Department of Biochemistry , and.
authors.forename: Fatmanur H
authors.initials: FH
authors.lastname: Kazanci
authors.affiliation: c Department of Biochemistry , and.
authors.forename: Sümeyye
authors.initials: S
authors.lastname: Gök
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
authors.affiliation: d Department of Medical Biology , Turgut Özal University School of Medicine , Ankara , Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Demircan
mesh_terms: D000071096:ADAMTS Proteins / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D000067596:Interleukin-33 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33; D000071096:ADAMTS Proteins; C496252:ADAMTS12 protein, human; C510098:ADAMTS16 protein, human; C510099:ADAMTS18 protein, human
keywords: ADAMTS12; ADAMTS16; ADAMTS18; IL-33; pre-eclampsia