title: Association of ADRB1 gene polymorphisms with pain sensitivity in a Chinese population.
abstract: OBJECTIVE
  The present study aims to observe the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain sensitivity.
  
  
  METHODS
  We analyzed the associations between pain sensitivity and ADRB1 gene SNPs (A145 G and G1165 C) in 324 Chinese patients who underwent surgery. The genotyping was performed using PCR-RFLP technique.
  
  
  RESULTS
  The patients who carried the A-allele of the A145 G SNP were more sensitive to cold pressor-induced pain than those who did not carry this allele (P < 0.05). We did not found G1165 C polymorphism associated with pain sensitive in the present study. The haplotype analysis revealed A-C haplotype carriers have reduced fentanyl use in 24-h postoperative (P < 0.05).
  
  
  CONCLUSIONS
  ADRB1 gene polymorphisms are associated with pain and analgesic sensitivity.
authors.affiliation: Department of Radiotherapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Radiotherapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Radiotherapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Radiotherapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Radiotherapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: School of Radiation Medicine and Protection, Soochow University Suzhou, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Radiotherapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Meng
keywords: gene polymorphism; individual difference; opioid; pain; β1-adrenergic receptor