title: Independence Day for IgA.
abstract: IgA is induced through T-cell-dependent and -independent pathways. In this issue, Bunker et al. (2015) now show that the T-cell-independent pathway is sufficient to coat most small intestinal microbes specifically, and Fransen et al. (2015) find that IgA coating promotes uptake of microbes into Peyer's patches and drives further induction in a positive-feedback loop.
authors.affiliation: Maurice Müller Laboratories, UVCM, University Hospital of Bern, 3010 Bern, Switzerland. Electronic address: andrew.macpherson@insel.ch.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Macpherson
authors.affiliation: Maurice Müller Laboratories, UVCM, University Hospital of Bern, 3010 Bern, Switzerland.
authors.forename: Kathy D
authors.initials: KD
authors.lastname: McCoy
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001419:Bacteria / Q000276:immunology*; D014644:Genetic Variation / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology*; D007070:Immunoglobulin A / Q000276:immunology*; D007421:Intestine, Small / Q000276:immunology*; D064307:Microbiota / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D007070:Immunoglobulin A