title: Stanniocalcin 2 promotes cell proliferation and cisplatin resistance in cervical cancer.
abstract: Cervical cancer is one of the most common carcinomas in the female reproductive system. Treatment of cervical cancer involves surgical removal and chemotherapy. Resistance to platinum-based chemotherapy drugs including cisplatin has increasingly become an important problem in the treatment of cervical cancer patients. We found in this study that stanniocalcin 2 (STC2) expression was upregulated in both cervical cancer tissues and cell lines. The levels of STC2 expression in cervical cancer cell lines were positively correlated with the rate of cell proliferation. Furthermore, in cisplatin resistant cervical cancer cells, the levels of STC2 expression were significantly elevated. Modulation of STC2 expression by siRNA or overexpression in cisplatin resistant cells resulted in altered cell survival, apoptosis, and cisplatin resistance. Finally, we found that there was significant difference in the activity of the MAPK signaling pathway between cisplatin sensitive and resistant cervical cancer cells, and that STC2 could regulate the activity of the MAPK signaling pathway.
authors.affiliation: Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, China.
authors.forename: Guichun
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China. Electronic address: tanwenhua1962@163.com.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Tan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D017209:Apoptosis; D045744:Cell Line, Tumor / Q000187:drug effects; D049109:Cell Proliferation; D002470:Cell Survival; D002945:Cisplatin / Q000737:chemistry*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006023:Glycoproteins / Q000502:physiology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D020935:MAP Kinase Signaling System; D034741:RNA, Small Interfering / Q000378:metabolism; D015398:Signal Transduction; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D034741:RNA, Small Interfering; C114997:STC2 protein, human; D002945:Cisplatin
keywords: Apoptosis; Cervical cancer; Cisplatin; MAPK; Proliferation; Stanniocalcin 2