title: Bifunctional chelating agents based on ionic carbosilane dendrons with DO3A at the focal point and their complexation behavior with copper(II).
abstract: A synthetic protocol has been designed to incorporate the DO3A ligand to the focal point of cationic or anionic carbosilane dendrons, affording a set of bifunctional chelating agents (BFCAs) useful for potential biomedical applications. The complexation behavior study of ionic BFCAs has been accomplished by UV-vis and electron paramagnetic resonance spectroscopy as well as potentiometric titrations. The presence of the dendron branches modifies the complexation capacity of the macrocyclic ring with respect to that of the 1,4,7,10-tetraazacyclodocecane-N,N',N″,N‴-tetraacetic acid (DOTA) ligand. Also, a different behavior has been observed in the carboxylate-terminated dendrons against analogous sulfonate- or amine-terminated dendrons in the contribution of the branches and peripheral groups to the coordination modes. The presence or not of Cu-S2O2 coordination sites and the generation can be important factors to take into account for considering a particular biomedical application.
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Universidad de Alcalá , Edificio de Farmacia 28871, Alcalá de Henares, Spain.|Spain/Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , C/ Poeta Mariano Esquillor s/n 50018, Zaragoza, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Moreno
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Universidad de Alcalá , Edificio de Farmacia 28871, Alcalá de Henares, Spain.|Spain/Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , C/ Poeta Mariano Esquillor s/n 50018, Zaragoza, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Ortega
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Universidad de Alcalá , Edificio de Farmacia 28871, Alcalá de Henares, Spain.|Spain/Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , C/ Poeta Mariano Esquillor s/n 50018, Zaragoza, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: de la Mata
authors.affiliation: Departments of Earth, Life and Environment Sciences, University of Urbino , Via Ca' le Suore 2/4, Urbino 61029, Italy.
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Ottaviani
authors.affiliation: Departments of Earth, Life and Environment Sciences, University of Urbino , Via Ca' le Suore 2/4, Urbino 61029, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Cangiotti
authors.affiliation: Departments of Earth, Life and Environment Sciences, University of Urbino , Via Ca' le Suore 2/4, Urbino 61029, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fattori
authors.affiliation: Laboratorio de Inmunobiologia Molecular, Hospital General Universitario Gregorio Marañon , Madrid, Spain.|Spain/Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , C/ Poeta Mariano Esquillor s/n 50018, Zaragoza, Spain.
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: Muñoz-Fernández
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Universidad de Alcalá , Edificio de Farmacia 28871, Alcalá de Henares, Spain.|Spain/Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , C/ Poeta Mariano Esquillor s/n 50018, Zaragoza, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Gómez
mesh_terms: D000085:Acetates / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: C000607932:1,4,7,10-tetraazacyclodocecane-N,N',N',N''-triacetic acid; D000085:Acetates; D001372:Aza Compounds; D002614:Chelating Agents; D050091:Dendrimers; D017646:Organosilicon Compounds; D003300:Copper