title: Preventive Role of Tetraspanin CD9 in Systemic Inflammation of Chronic Obstructive Pulmonary Disease.
abstract: Chronic obstructive pulmonary disease (COPD) is frequently associated with extrapulmonary complications, including cardiovascular disease, diabetes, and osteoporosis. Persistent, low-grade, systemic inflammation underlies these comorbid disorders. Tetraspanins, which have a characteristic structure spanning the membrane four times, facilitate lateral organization of molecular complexes and thereby form tetraspanin-enriched microdomains that are distinct from lipid rafts. Recent basic research has suggested a preventive role of tetraspanin CD9 in COPD. CD9-enriched microdomains negatively regulate LPS-induced receptor formation by preventing CD14 from accumulating into the rafts, and decreased CD9 in macrophages enhances inflammation in mice. Mice doubly deficient in CD9 and a related tetraspanin, CD81, show pulmonary emphysema, weight loss, and osteopenia, a phenotype akin to human COPD. A therapeutic approach to up-regulating CD9 in macrophages might improve the clinical course of patients with COPD with comorbidities.
authors.affiliation: 1 Department of Respiratory Medicine, Allergy, and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, and.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: 2 Department of Medicine, Nissay Hospital, Nippon Life Saiseikai Public Interest Incorporated Foundation, Nishi-ku, Osaka, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: 1 Department of Respiratory Medicine, Allergy, and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, and.
authors.forename: Yingji
authors.initials: Y
authors.lastname: Jin
authors.affiliation: 2 Department of Medicine, Nissay Hospital, Nippon Life Saiseikai Public Interest Incorporated Foundation, Nishi-ku, Osaka, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Tachibana
mesh_terms: D000818:Animals; D006801:Humans; D008262:Macrophage Activation; D021962:Membrane Microdomains / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology*; D060245:Tetraspanin 29 / Q000502:physiology*; D015854:Up-Regulation
chemical_list: C554869:CD9 protein, human; D060245:Tetraspanin 29
keywords: CD9; chronic obstructive pulmonary disease; inflammation; macrophage; tetraspanin