title: New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity.
abstract: New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (2-8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, the new compound (1) was found to exhibit selective inhibitory activity on PTP1B with IC50value 15.2 ± 1.4 µM.
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, 132013, Jilin Province, People's Republic of China.
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Li
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, 132013, Jilin Province, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, 132013, Jilin Province, People's Republic of China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Xing
authors.affiliation: The Second Affiliated Hospital of Shenyang Medical College, 20 Beijiu Road, Shenyang, 110000, Liaoning, People's Republic of China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, 132013, Jilin Province, People's Republic of China.
authors.forename: Ban-Ban
authors.initials: BB
authors.lastname: Li
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, 132013, Jilin Province, People's Republic of China.
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Chen
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk, 363-883, Republic of Korea.
authors.forename: Jong-Seog
authors.initials: JS
authors.lastname: Ahn
authors.affiliation: College of Pharmacy, Beihua University, Jilin City, 132013, Jilin Province, People's Republic of China. cuilong71@beihua.edu.cn.
authors.forename: Long
authors.initials: L
authors.lastname: Cui
mesh_terms: D028001:Eleutherococcus / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D013057:Spectrum Analysis
chemical_list: D004791:Enzyme Inhibitors; D017705:Lignans; D010936:Plant Extracts; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Acanthopanax senticosus; Araliaceae; Neo-lignan; PTP1B