title: Diurnal versus office-hour intraocular pressure fluctuation in primary adult onset glaucoma.
abstract: OBJECTIVE
  To evaluates the role of measuring intraocular pressure (IOP) outside office-hour in primary adult onset glaucoma.
  
  
  METHODS
  This retrospective study included 100 cases of primary adult onset glaucoma. IOP readings obtained with Goldmann applanation tonometry between 7 am and 10 pm were compared to office-hour readings.
  
  
  RESULTS
  One hundred patients were enrolled (mean age: 58.64 ± 10.98 years) in the study. Overall, mean diurnal IOP was significantly higher than mean office IOP (p < 0.05). Two-thirds of the patients had peak IOP measurements outside office-hour. Mean diurnal IOP fluctuation (7.03 ± 2.69 mm Hg) was significantly higher than mean office IOP fluctuation (4.31 ± 2.6 mm Hg) (p < 0.003). There was a significant correlation between baseline IOP and fluctuation in IOP (r = 0.61, p<0.001).
  
  
  CONCLUSIONS
  The mean diurnal IOP and IOP fluctuations were higher than office-hour readings in patients with primary adult onset glaucoma. Diurnal monitoring may be particularly useful in patients with high baseline IOP.
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Arora
authors.affiliation: Ivey Eye Institute, Schulich School of Medicine and Dentistry, London, ON, Canada.
authors.forename: Shveta Jindal
authors.initials: SJ
authors.lastname: Bali
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Vishal
authors.initials: V
authors.lastname: Arora
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Wadhwani
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Panda
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: tanujdada@gmail.com.
authors.forename: Tanuj
authors.initials: T
authors.lastname: Dada
mesh_terms: D000328:Adult; D000368:Aged; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005901:Glaucoma / Q000503:physiopathology*; D005902:Glaucoma, Open-Angle; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D014065:Tonometry, Ocular
keywords: Diurnal fluctuation; Fluctuación diurna; Glaucoma primario de ángulo cerrado; Intraocular pressure; Presión intraocular; Primary angle closure glaucoma