title: Glucose diffusivity in cell-seeded tissue engineering scaffolds.
abstract: OBJECTIVE
  To determine the effective glucose diffusion coefficient in cell-seeded porous scaffolds to understand the importance of nutrient diffusion in tissue engineering bioreactors.
  
  
  RESULTS
  Cell growth changed the morphological structure of the scaffolds decreasing the effective pore space and, inevitably, decreasing the effective glucose diffusivity in the chosen scaffolds, namely, collagen, poly(L-lactide) and poly(caprolactone) scaffolds from 3.7 × 10(-9) to 3.2 × 10(-9) m(2)/s, 1.4 × 10(-10) to 9.1 × 10(-11) m(2)/s and 1.8 × 10(-10) to 1.3 × 10(-10) m(2)/s, respectively.
  
  
  CONCLUSIONS
  The presence of cells over time during cell culture reduces the mobility of glucose. The results can predict the glucose concentration profiles in thick engineered tissues.
authors.affiliation: Department of Chemical Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK.
authors.forename: Hazwani
authors.initials: H
authors.lastname: Suhaimi
authors.affiliation: Department of Chemical Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK. D.B.Das@lboro.ac.uk.
authors.forename: Diganta Bhusan
authors.initials: DB
authors.lastname: Das
mesh_terms: D001672:Biocompatible Materials; D002460:Cell Line; D049109:Cell Proliferation; D005947:Glucose / Q000032:analysis*; D006801:Humans; D010006:Osteoblasts / Q000166:cytology*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D005947:Glucose
keywords: Diffusion coefficient; Glucose; Osteoblast cell; Scaffold; Tissue engineering