title: Modeling a healthy and a person with heart failure conditions using the object-oriented modeling environment Dymola.
abstract: Several mathematical models of different physiological systems are spread through literature. They serve as tools which improve the understanding of (patho-) physiological processes, may help to meet clinical decisions and can even enhance medical therapies. These models are typically implemented in a signal-flow-oriented simulation environment and focus on the behavior of one specific subsystem. Neglecting other physiological subsystems and using a technical description of the physiology hinders the exchange with and acceptance of clinicians. By contrast, this paper presents a new model implemented in a physical, object-oriented modeling environment which includes the cardiovascular, respiratory and thermoregulatory system. Simulation results for a healthy subject at rest and at the onset of exercise are given, showing the validity of the model. Finally, simulation results showing the interaction of the cardiovascular system with a ventricular assist device in case of heart failure are presented showing the flexibility and mightiness of the model and the simulation environment. Thus, we present a new model including three important physiological systems and one medical device implemented in an innovative simulation environment.
authors.affiliation: Philips Chair for Medical Information Technology, RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germany. heinke@hia.rwth-aachen.de.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Heinke
authors.affiliation: Philips Chair for Medical Information Technology, RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germany.
authors.forename: Carina
authors.initials: C
authors.lastname: Pereira
authors.affiliation: Philips Chair for Medical Information Technology, RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Leonhardt
authors.affiliation: Philips Chair for Medical Information Technology, RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germany.
authors.forename: Marian
authors.initials: M
authors.lastname: Walter
mesh_terms: D003198:Computer Simulation; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006801:Humans; D008955:Models, Cardiovascular; D014584:User-Computer Interface
keywords: Cardiovascular system; Object-oriented modeling; Respiratory system; Thermoregulation; Ventricular assist device