title: Aspertetranones A-D, Putative Meroterpenoids from the Marine Algal-Associated Fungus Aspergillus sp. ZL0-1b14.
abstract: Aspertetranones A-D (1-4), four new highly oxygenated putative rearranged triketide-sesquiterpenoid meroterpenes, were isolated from the marine algal-associated fungus Aspergillus sp. ZL0-1b14. On the basis of a comprehensive spectroscopic analysis, the planar structures of aspertetranones were determined to possess an unusual skeleton in the terpenoid part. The relative and absolute configurations of the aspertetranones were assigned on the basis of NOESY analysis, X-ray crystallography, and circular dichroism spectroscopy. Compounds 1-4 were evaluated for anti-inflammatory activity in LPS-stimulated RAW264.7 macrophages. Aspertetranone D exhibited an inhibitory effect against IL-6 production with 69% inhibition at 40 μM.
authors.forename: Yuezhou
authors.initials: Y
authors.lastname: Wang
authors.forename: Shuang
authors.initials: S
authors.lastname: Qi
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fujian Medical University , Fuzhou, Fujian 350108, China.
authors.forename: Nanwen
authors.initials: N
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for Physical Chemistry of Solid Surface, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, Fujian 361005, China.|Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry , Xiamen, Fujian China.
authors.forename: An-An
authors.initials: AA
authors.lastname: Wu
authors.forename: Fu
authors.initials: F
authors.lastname: Gui
authors.forename: Kai
authors.initials: K
authors.lastname: Guo
authors.forename: Yanru
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo , 924 Stainback Hwy, Hilo, Hawaii 96720, United States ;|Natural Products and Experimental Therapeutics, Cancer Center, University of Hawai'i at Manoa , 701 Ilalo Street, Honolulu, Hawaii 96813, United States.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Hu
authors.forename: Zhonghui
authors.initials: Z
authors.lastname: Zheng
authors.forename: Siyang
authors.initials: S
authors.lastname: Song
authors.forename: Qingyan
authors.initials: Q
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan, Shandong 250012, China.
authors.forename: Yuemao
authors.initials: Y
authors.lastname: Shen
authors.forename: Xianming
authors.initials: X
authors.lastname: Deng
mesh_terms: D000465:Algorithms; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002681:China; D018360:Crystallography, X-Ray; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008386:Marine Biology; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide / Q000032:analysis; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000093242:Interleukin-6 Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D012717:Sesquiterpenes; D000093242:Interleukin-6 Inhibitors; C000604830:aspertetranone D