title: Computational analysis of amoeboid swimming at low Reynolds number.
abstract: Recent experimental work has shown that eukaryotic cells can swim in a fluid as well as crawl on a substrate. We investigate the swimming behavior of Dictyostelium discoideum  amoebae who swim by initiating traveling protrusions at the front that propagate rearward. In our model we prescribe the velocity at the surface of the swimming cell, and use techniques of complex analysis to develop 2D models that enable us to study the fluid-cell interaction. Shapes that approximate the protrusions used by Dictyostelium discoideum  can be generated via the Schwarz-Christoffel transformation, and the boundary-value problem that results for swimmers in the Stokes flow regime is then reduced to an integral equation on the boundary of the unit disk. We analyze the swimming characteristics of several varieties of swimming Dictyostelium discoideum  amoebae, and discuss how the slenderness of the cell body and the shapes of the protrusion effect the swimming of these cells. The results may provide guidance in designing low Reynolds number swimming models.
authors.affiliation: University of California, 540R Rowland Hall, Irvine, USA. qixuanw@uci.edu.
authors.forename: Qixuan
authors.initials: Q
authors.lastname: Wang
authors.affiliation: School of Mathematics, University of Minnesota, 270A Vincent Hall, Minneapolis, USA.
authors.forename: Hans G
authors.initials: HG
authors.lastname: Othmer
mesh_terms: D004023:Dictyostelium / Q000502:physiology*; D008954:Models, Biological; D013550:Swimming
keywords: Amoeboid swimmimg; Low Reynolds number swimming; Metastasis; Robotic swimmers; Self-propulsion