title: Effect of parenterally L-arginine supplementation on the respiratory distress syndrome in preterm newborns.
abstract: L-Arginine (L-Arg) is the precursor of nitric oxide which plays an important role on pulmonary circulation and pulmonary vascular tone. Earlier studies suggested that L-Arg levels in preterm newborns with respiratory distress syndrome (RDS) were low due to its consumption and L-Arg supplementation may reduce the severity of RDS. Our aim was detect the effect of the parenterally L-Arg supplementation on RDS severity. The subjects were chosen between preterm newborns (gestational age <34 weeks) (n = 30). Twenty of the subjects were diagnosed with permaturity and RDS, and 10 of the subjects were healthy preterm newborns. Ten of the subjects was taken L-Arg (1.5 mmol/kg/d) in addition to routine RDS treatment and assumed as "Group 1". In this group, daily L-Arg supplementation was started end of the first day, and continued at end of fifth day. The others of the subjects diagnosed with RDS was take routine RDS treatment and assumed as "Group 2". Healthy preterm newborns assumed as "Group 3". Blood collections for L-Arg levels via tandem mass spectrometry were made in first day and repeated on the seventh days. Oxygenation index was used to determine severity of RDS. L-Arg consentrations in Group 1 were 8.7 ± 4.1 μM/L and 11.9 ± 5.0 μM/L in first and seventh day, respectively. L-Arg consentrations were 12.6 ± 4.5 μM/Land 10.9 ± 5.4 μM/L in Group 2 and 8.6 ± 5.1 μM/L and 9.4 ± 4.1 μM/L in Group 3. There is no correlation between L-Arg concentrations and OI also duration of the mechanical ventilation of the subjects in patient groups (Group 1 and 2).
authors.affiliation: a Department of Pediatrics, Faculty of Medicine , Erciyes University , Kayseri , Turkey .
authors.forename: Murat
authors.initials: M
authors.lastname: Cansever
authors.affiliation: b Division of Neonatology, Department of Pediatrics, Faculty of Medicine , Erciyes University , Kayseri , Turkey , and.
authors.forename: Mustafa Ali
authors.initials: MA
authors.lastname: Akin
authors.affiliation: a Department of Pediatrics, Faculty of Medicine , Erciyes University , Kayseri , Turkey .|c Department of Pediatrics , Akdeniz University Medical School , Antalya , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akcakus
authors.affiliation: a Department of Pediatrics, Faculty of Medicine , Erciyes University , Kayseri , Turkey .
authors.forename: Alper
authors.initials: A
authors.lastname: Ozcan
authors.affiliation: b Division of Neonatology, Department of Pediatrics, Faculty of Medicine , Erciyes University , Kayseri , Turkey , and.
authors.forename: Tamer
authors.initials: T
authors.lastname: Gunes
authors.affiliation: b Division of Neonatology, Department of Pediatrics, Faculty of Medicine , Erciyes University , Kayseri , Turkey , and.
authors.forename: Adnan
authors.initials: A
authors.lastname: Ozturk
authors.affiliation: b Division of Neonatology, Department of Pediatrics, Faculty of Medicine , Erciyes University , Kayseri , Turkey , and.
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoglu
mesh_terms: D000328:Adult; D001120:Arginine / Q000097:blood / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010288:Parenteral Nutrition; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D053719:Tandem Mass Spectrometry
chemical_list: D001120:Arginine
keywords: l-Arginine; prematurity; respiratory distress syndrome