title: [Comparison of different doses of escitalopram in the prevention of dementia in patients with depression and moderate cognitive dysfunction associated with chronic brain ischemia].
abstract: OBJECTIVE
  to compare different doses of escitalopram (cipralex) in the prevention of dementia in patients with depression and moderate cognitive dysfunction associated with chronic brain ischemia.
  
  
  METHODS
  Two groups of patients, aged 65-78 years, with chronic brain ischemia and mild or moderate depression with moderate cognitive dysfunction were treated with different doses of escitalopram: 30 patients received 5 mg daily during all treatment period; 42 patients - 5 mg daily during the first week and 10 mg from the second week of treatment. The treatment lasted for 6 months; the period of observation was 8 months.
  
  
  CONCLUSIONS
  The efficacy of escitalopram is demonstrated not only for the treatment of depression associated with cognitive dysfunction in patients with chronic brain ischemia but for decrease of the risk of dementia in long-term period.
authors.affiliation: Interregional Clinical Diagnostic Center, Kazan.
authors.forename: J V
authors.initials: JV
authors.lastname: Zhitkova
mesh_terms: D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D002908:Chronic Disease; D015283:Citalopram / Q000008:administration & dosage*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D003704:Dementia / Q000209:etiology / Q000517:prevention & control*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors