title: Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control.
abstract: BACKGROUND
  Impaired speech prosody is common in Parkinson's disease (PD). We assessed the impact of PD and levodopa on MRI resting-state functional connectivity (rs-FC) underlying speech prosody control.
  
  
  METHODS
  We studied 19 PD patients in the OFF and ON dopaminergic conditions and 15 age-matched healthy controls using functional MRI and seed partial least squares correlation (PLSC) analysis. In the PD group, we also correlated levodopa-induced rs-FC changes with the results of acoustic analysis.
  
  
  RESULTS
  The PLCS analysis revealed a significant impact of PD but not of medication on the rs-FC strength of spatial correlation maps seeded by the anterior cingulate (p = 0.006), the right orofacial primary sensorimotor cortex (OF_SM1; p = 0.025) and the right caudate head (CN; p = 0.047). In the PD group, levodopa-induced changes in the CN and OF_SM1 connectivity strengths were related to changes in speech prosody.
  
  
  CONCLUSIONS
  We demonstrated an impact of PD but not of levodopa on rs-FC within the brain networks related to speech prosody control. When only the PD patients were taken into account, the association between treatment-induced changes in speech prosody and changes in rs-FC within the associative striato-prefrontal and motor speech networks was found.
authors.affiliation: Brain and Mind Research Program, Central European Institute of Technology, CEITEC MU, Masaryk University, Brno, Czech Republic; First Department of Neurology, School of Medicine, Masaryk University and St. Anne's Hospital, Brno, Czech Republic.
authors.forename: Nela
authors.initials: N
authors.lastname: Elfmarková
authors.affiliation: Brain and Mind Research Program, Central European Institute of Technology, CEITEC MU, Masaryk University, Brno, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Gajdoš
authors.affiliation: Brain and Mind Research Program, Central European Institute of Technology, CEITEC MU, Masaryk University, Brno, Czech Republic; First Department of Neurology, School of Medicine, Masaryk University and St. Anne's Hospital, Brno, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Mračková
authors.affiliation: Department of Telecommunications, Faculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Mekyska
authors.affiliation: Brain and Mind Research Program, Central European Institute of Technology, CEITEC MU, Masaryk University, Brno, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Mikl
authors.affiliation: Brain and Mind Research Program, Central European Institute of Technology, CEITEC MU, Masaryk University, Brno, Czech Republic; First Department of Neurology, School of Medicine, Masaryk University and St. Anne's Hospital, Brno, Czech Republic. Electronic address: irena.rektorova@fnusa.cz.
authors.forename: Irena
authors.initials: I
authors.lastname: Rektorová
mesh_terms: D000368:Aged; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000187:drug effects / Q000378:metabolism*; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D012146:Rest / Q000502:physiology*; D013060:Speech / Q000187:drug effects / Q000502:physiology*; D013064:Speech Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism
chemical_list: D007980:Levodopa
keywords: Acoustic; Caudate nucleus; Dopaminergic; Functional connectivity; Levodopa; Motor speech network; Parkinson's disease; Resting state; Speech prosody; fMRI