title: Successful Treatment of Carbapenemase-Producing Pandrug-Resistant Klebsiella pneumoniae Bacteremia.
abstract: New antibiotic options are urgently needed for the treatment of carbapenem-resistant Enterobacteriaceae infections. We report a 64-year-old female with prolonged hospitalization following an intestinal transplant who developed refractory bacteremia due to a serine carbapenemase-producing pandrug-resistant isolate of Klebsiella pneumoniae. After failing multiple antimicrobial regimens, the patient was successfully treated.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA jfc31@med.miami.edu rafael.canton@salud.madrid.org.
authors.forename: Jose F
authors.initials: JF
authors.lastname: Camargo
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Jacques
authors.initials: J
authors.lastname: Simkins
authors.affiliation: Miami Transplant Institute and Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Thiago
authors.initials: T
authors.lastname: Beduschi
authors.affiliation: Miami Transplant Institute and Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Akin
authors.initials: A
authors.lastname: Tekin
authors.affiliation: Department of Pharmacy, Jackson Memorial Hospital, Miami, Florida, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Aragon
authors.affiliation: Department of Microbiology, Jackson Memorial Hospital, Miami, Florida, USA.
authors.forename: Armando
authors.initials: A
authors.lastname: Pérez-Cardona
authors.affiliation: Department of Microbiology, University of Miami, Miami, Florida, USA.
authors.forename: Clara E
authors.initials: CE
authors.lastname: Prado
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Michele I
authors.initials: MI
authors.lastname: Morris
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Lilian M
authors.initials: LM
authors.lastname: Abbo
authors.affiliation: Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain jfc31@med.miami.edu rafael.canton@salud.madrid.org.
authors.forename: Rafael
authors.initials: R
authors.lastname: Cantón
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use; D053961:Azabicyclo Compounds / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D001426:Bacterial Proteins / Q000096:biosynthesis*; D015780:Carbapenems / Q000627:therapeutic use; D002442:Ceftazidime / Q000627:therapeutic use; D003082:Colectomy; D003091:Colistin / Q000627:therapeutic use; D004338:Drug Combinations; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D015774:Ganciclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007421:Intestine, Small / Q000187:drug effects* / Q000382:microbiology / Q000637:transplantation; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives / Q000627:therapeutic use; D013845:Thienamycins / Q000627:therapeutic use; D000078304:Tigecycline; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D000077562:Valganciclovir; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D053961:Azabicyclo Compounds; D001426:Bacterial Proteins; D015780:Carbapenems; D004338:Drug Combinations; D007166:Immunosuppressive Agents; D013845:Thienamycins; C000595613:avibactam, ceftazidime drug combination; D000078304:Tigecycline; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002442:Ceftazidime; D001618:beta-Lactamases; C063912:carbapenemase; D000077731:Meropenem; D008911:Minocycline; D000077562:Valganciclovir; D015774:Ganciclovir; D003091:Colistin