title: Metals as radio-enhancers in oncology: The industry perspective.
abstract: Radio-enhancers, metal-based nanosized agents, could play a key role in oncology. They may unlock the potential of radiotherapy by enhancing the radiation dose deposit within tumors when the ionizing radiation source is 'on', while exhibiting chemically inert behavior in cellular and subcellular systems when the radiation beam is 'off'. Important decision points support the development of these new type of therapeutic agents originated from nanotechnology. Here, we discuss from an industry perspective, the interest of developing radio-enhancer agents to improve tumor control, the relevance of nanotechnology to achieve adequate therapeutic attributes, and present some considerations for their development in oncology.
authors.affiliation: Nanobiotix, 60 rue de Wattignies, 75012 Paris, France. Electronic address: agnes.pottier@nanobiotix.com.
authors.forename: Agnés
authors.initials: A
authors.lastname: Pottier
authors.affiliation: Nanobiotix, 60 rue de Wattignies, 75012 Paris, France.
authors.forename: Elsa
authors.initials: E
authors.lastname: Borghi
authors.affiliation: Nanobiotix, 60 rue de Wattignies, 75012 Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Levy
mesh_terms: D000818:Animals; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D011878:Radiotherapy / Q000379:methods*
chemical_list: D053769:Nanocapsules; D011838:Radiation-Sensitizing Agents
keywords: Cancer; Nanotechnology; Radio-enhancer; Radiotherapy