title: Congenital malformations caused by Stryphnodendron fissuratum (Leg. Mimosoideae) in guinea pigs (Cavia porcellus).
abstract: The aim of this study was to evaluate the toxicity of Stryphnodendron fissuratum pods in guinea pigs (Cavia porcellus) and test the hypothesis that this plant has teratogenic effects. Thus, sixteen guinea pigs were randomly divided into four groups of four animals each. Groups 10, 20 and 40 consisted of guinea pigs that received commercial food that contained crushed pods of S. fissuratum at concentrations of 10, 20 and 40 g/kg, respectively, during the period of organogenesis. Control group consisted of guinea pigs under the same management conditions that did not receive crushed pods of S. fissuratum in their food. In all experimental groups, the main clinical signs of poisoning consisted of anorexia, prostration, absence of vocalizations, alopecia, diarrhea, and abortions within the adult guinea pigs. Those that did not abort gave birth to weak, malnourished pups, some of which had fetal malformations. The main teratogenic changes consisted of eventration, arthrogryposis, amelia of the forelimbs, anophthalmia, microphthalmia, anotia and agnathia. The reductions in the number of offspring and the malformations observed in the experimental groups suggest that S. fissuratum affects fetal development and is teratogenic.
authors.affiliation: Laboratório de Diagnóstico Animal, DMFA/UFRPE, 52171-900, Recife, PE, Brazil.
authors.forename: Josenaldo S
authors.initials: JS
authors.lastname: Macedo
authors.affiliation: Laboratório de Diagnóstico Animal, DMFA/UFRPE, 52171-900, Recife, PE, Brazil.
authors.forename: Brena P
authors.initials: BP
authors.lastname: Rocha
authors.affiliation: Laboratório de Patologia Veterinária, UFMT, Cuiabá, MT, 78068-900, Brazil.
authors.forename: Edson M
authors.initials: EM
authors.lastname: Colodel
authors.affiliation: Hospital Veterinário, UNIC, Cuiabá, MT, 78065-900, Brazil.
authors.forename: Sílvio H
authors.initials: SH
authors.lastname: Freitas
authors.affiliation: Hospital Veterinário, USP, Pirassununga, SP, 13635-900, Brazil.
authors.forename: Renata G S
authors.initials: RG
authors.lastname: Dória
authors.affiliation: Estación Experimental La Estanzuela, INIA, Ruta 50, Km 11, Colonia, Uruguay.
authors.forename: Franklin
authors.initials: F
authors.lastname: Riet-Correa
authors.affiliation: Laboratório de Diagnóstico Animal, DMFA/UFRPE, 52171-900, Recife, PE, Brazil.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Evêncio-Neto
authors.affiliation: Laboratório de Diagnóstico Animal, DMFA/UFRPE, 52171-900, Recife, PE, Brazil. Electronic address: fabio.mendonca@pq.cnpq.br.
authors.forename: Fábio S
authors.initials: FS
authors.lastname: Mendonça
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D007887:Fabaceae / Q000633:toxicity*; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D006168:Guinea Pigs / Q000196:embryology*; D018811:Maternal Exposure; D038081:Organogenesis / Q000187:drug effects; D011247:Pregnancy; D011897:Random Allocation; D013723:Teratogens / Q000633:toxicity*
chemical_list: D013723:Teratogens
keywords: Abortions; Poisonous plants; Stryphnodendron fissuratum; Teratogenesis