title: Estimation of the symptoms for GERD by GerdQ in the patients with rheumatic diseases.
abstract: OBJECTIVE
  Gastroesophageal reflux disease (GERD) is one of the most common comorbidity in many diseases, but the frequency in rheumatic disease has not been well understood.
  
  
  METHODS
  We investigated the prevalence of GERD by GerdQ in 530 rheumatic patients [systematic lupus erythematosus (SLE; n = 120), rheumatoid arthritis (RA; n = 117), polymyalgia rheumatica (PMR; n = 40), dermatomyositis and polymyositis (PM/DM; n = 38), systemic scleroderma (SSc; n = 37), mixed connective tissue disease (MCTD; n = 18), Behçet disease (BD; n = 17), adult onset still disease (AOSD; n = 14), and other rheumatic diseases (n = 129)].
  
  
  RESULTS
  The mean GerdQ scores of patients was 6.2 ± 1.8, respectively, and no significant differences were observed between all patients. However, the GERD prevalence in SSc and BD was increased compared to that in SLE, RA, PMR, PM/DM, MCTD, and AOSD. In no medication of proton pump inhibitors (PPIs), a significant increase in the risk of GERD symptoms was 2.5 times compared with that in the medication of PPIs in all patients by multivariable regression analysis. On the other hand, there were no increased risks of GERD symptoms with corticosteroids.
  
  
  CONCLUSIONS
  In rheumatic diseases, GerdQ would be the useful tool of diagnosis GERD, regardless whether the patients complain or not about gastrointestinal (GI) symptoms.
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nozaki
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Kinoshita
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Jinhai
authors.initials: J
authors.lastname: Ri
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sakai
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shiga
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Hino
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Hirooka
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Masahumi
authors.initials: M
authors.lastname: Sugiyama
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Funauchi
authors.affiliation: a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka-Sayama, Osaka , Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Matsumura
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012216:Rheumatic Diseases / Q000453:epidemiology*; D063189:Symptom Assessment
keywords: Gastroesophageal reflux disease; Rheumatic disease