title: Analysis of the Influence of Hormone Replacement Therapy on Osteocalcin Gene Expression in Postmenopausal Women.
abstract: BACKGROUND
  Osteocalcin (OC) contributes to the process of bone mineralization. Present study was designed to investigate the changes in OC gene expression of postmenopausal women treated with hormone replacement therapy (HRT). Study was also designed to evaluate OC gene expression in cells which are not part of connective tissue.
  
  
  METHODS
  Research was carried out on 30 postmenopausal women not treated and 30 treated with HRT. Examination of OC gene expression was conducted on peripheral blood lymphocytes (PBL) and buccal epithelial lining (BEL). Densitometry was conducted on femur and mandible.
  
  
  RESULTS
  Tests revealed OC gene expression in BEL and PBL. BMD was higher in groups treated with HRT. Assessment of correlation between the OC gene expression in BEL and BMD of mandible revealed significant positive relation.
  
  
  CONCLUSIONS
  OC gene expression can be stated BEL and PBL. Analysis of correlation between OC gene expression in oral cavity and mandible BMD showed significant correlation between local OC expression and local bone metabolism. The relation between OC gene expression and bone metabolism is complex and further research is needed to clear all of the uncertainties.
authors.affiliation: The Chair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7 Street, 20-081 Lublin, Poland.
authors.forename: Mansur
authors.initials: M
authors.lastname: Rahnama
authors.affiliation: The Chair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7 Street, 20-081 Lublin, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Jastrzębska-Jamrogiewicz
authors.affiliation: The Chair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7 Street, 20-081 Lublin, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Jamrogiewicz
authors.affiliation: The Department of Oral Surgery, Pomeranian Medical University, Al. Powstańców Wlkp. 72, 70-111 Szczecin, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Trybek
mesh_terms: D015519:Bone Density / Q000235:genetics; D016022:Case-Control Studies; D003720:Densitometry / Q000379:methods; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D005269:Femur / Q000378:metabolism; D015870:Gene Expression / Q000235:genetics*; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008334:Mandible / Q000378:metabolism; D008875:Middle Aged; D015675:Osteocalcin / Q000235:genetics*; D015663:Osteoporosis, Postmenopausal / Q000235:genetics; D017698:Postmenopause / Q000235:genetics*
chemical_list: D015675:Osteocalcin