title: Canine Pancreas-Specific Lipase and C-reactive Protein in Dogs Treated With Anticonvulsants (Phenobarbital and Potassium Bromide).
abstract: Animals treated with anticonvulsant drugs may have increased canine pancreas-specific lipase (cPLI) values. Inflammatory conditions and specifically acute pancreatitis are of major concern in these animals. Elevation in C-reactive protein is being associated with inflammatory status in dogs and it has been correlated with the clinical severity of pancreatitis. In the present study, we investigated if there is a correlation between the cPLI increase, changes in C-reactive protein and hepatic enzymes, as well as the incidence of severe acute pancreatitis (AP) in dogs with anticonvulsant treatment (phenobarbital, or potassium bromide or both). Increased values of pancreas-specific lipase were found in 6.8% of the animals in treatment with anticonvulsants, and this increase is correlated with the increase in triglycerides, alkaline phosphatase, and alanine aminotransferase but not with C-reactive protein levels, which suggests a possible induction or release phenomenon rather than a clear severe AP. C-reactive protein levels did not affect cPLI values on the population studied. Only 2 animals had clinical and analytical data suggestive of AP, indicating a low prevalence (0.6%). In conclusion, cPLI may be increased in a low percentage of animals with anticonvulsants treatment and its increase may not be associated with severe AP. It may be induced by the anticonvulsants drugs; however, further studies are advised to rule out other possible causes that increased cPLI.
authors.affiliation: Hospital Clinic Veterinari Fundation, Autonomous University of Barcelona, Bellaterra, Spain.
authors.forename: Viviana
authors.initials: V
authors.lastname: Albarracín
authors.affiliation: Department of Cell Biology, Physiology, and Immunology, Faculty of Biosciences, Autonomous University of Barcelona, Bellaterra, Spain. Electronic address: mteles0@gmail.com.
authors.forename: Mariana
authors.initials: M
authors.lastname: Teles
authors.affiliation: Department of Animal Medicine and Surgery, Veterinary Faculty, Autonomous University of Barcelona, Bellaterra, Spain; Hospital Clinic Veterinari Fundation, Autonomous University of Barcelona, Bellaterra, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Meléndez-Lazo
authors.affiliation: Idexx Laboratories, Barcelona, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Rodón
authors.affiliation: Department of Animal Medicine and Surgery, Veterinary Faculty, Autonomous University of Barcelona, Bellaterra, Spain; Hospital Clinic Veterinari Fundation, Autonomous University of Barcelona, Bellaterra, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Pastor
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects*; D001965:Bromides / Q000009:adverse effects; D002097:C-Reactive Protein / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D004285:Dogs; D004827:Epilepsy / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D008049:Lipase / Q000097:blood*; D008297:Male; D010179:Pancreas / Q000201:enzymology; D010195:Pancreatitis / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D010634:Phenobarbital / Q000009:adverse effects; D017680:Potassium Compounds / Q000009:adverse effects
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D017680:Potassium Compounds; D002097:C-Reactive Protein; D008049:Lipase; C039004:potassium bromide; D010634:Phenobarbital
keywords: CRP; Spec cPL; acute pancreatitis; anticonvulsant treatment; dogs