title: IFNL4 rs368234815 polymorphism is associated with innate resistance to HIV-1 infection.
abstract: The interferon (IFN)L4 polymorphism rs368234815 is associated with hepatitis C virus (HCV) spontaneous clearance and response to IFN-based treatments. The role of this polymorphism in HIV-1 infection is controversial. We investigated whether genetic variation at IFNL4 is associated to HIV-1 acquisition. The HCV protective allele TT was associated with decreased likelihood of HIV-1 infection in male intravenous drug users [odds ratio (OR): 0.3; P = 0.006], and this association was not modified by the genotype of CCR5. These results suggest that genetic susceptibility to HCV and HIV-1 infection shares common molecular pathways.
authors.affiliation: aInfectious Diseases and Microbiology Clinical Unit, Valme Hospital, Seville bImmunogenetics Unit, Department of Experimental Biology, University of Jaen, Jaen cMaimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/Reina Sofia University Hospital, Cordoba dDepartamento de Enfermedades Infecciosas, Hospital Carlos III, Madrid eServicio de Medicina Interna, Hospital de la Santa Creu i Sant Pau, Barcelona fHuman Genetics Unit, Department of Basic Medical Sciences, University of Lleida IRBLleida, Lleida, Catalonia, Spain.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Real
authors.forename: Rocío
authors.initials: R
authors.lastname: Herrero
authors.forename: Antonio
authors.initials: A
authors.lastname: Rivero-Juárez
authors.forename: Ángela
authors.initials: Á
authors.lastname: Camacho
authors.forename: Juan
authors.initials: J
authors.lastname: Macías
authors.forename: Sandra
authors.initials: S
authors.lastname: Vic
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
authors.forename: Sergio
authors.initials: S
authors.lastname: Viedma
authors.forename: Josep M
authors.initials: JM
authors.lastname: Guardiola
authors.forename: Joan
authors.initials: J
authors.lastname: Fibla
authors.forename: Antonio
authors.initials: A
authors.lastname: Rivero
authors.forename: Juan A
authors.initials: JA
authors.lastname: Pineda
authors.forename: Antonio
authors.initials: A
authors.lastname: Caruz
mesh_terms: D060467:Disease Resistance; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology*; D015497:HIV-1; D006526:Hepatitis C / Q000235:genetics / Q000276:immunology; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D000095022:Interferon Lambda
chemical_list: D007378:Interleukins; C579163:IFNL4 protein, human; D000095022:Interferon Lambda