title: Lymphangioma Circumscriptum: Clinicopathological Spectrum of 29 Cases.
abstract: OBJECTIVE
  To describe the clinicopathological spectrum of Lymphangioma Circumscriptum (LC).
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  Department of Pathology and Microbiology, AKUH, Karachi, from 2002 to 2012.
  
  
  METHODS
  All reported cases of LC were retrieved from medical record. Clinical and pathological features were noted. Frequency percentages were determined.
  
  
  RESULTS
  There were 29 cases of LC predominantly males (62%). The mean age was 27.17 ±15.5 years. The commonest sites was anal/perianal region (24%) followed by extremities (17%) and tongue, (14%). Vulval LC was seen in 3 patients. Two cases were described on scrotum. The lesions were most commonly suspected as viral warts, mole or polyp (in anal region). Vesicles with erosions and bleeding and localized growth were the usual clinical presentations. Four of the patients presented with swelling since birth. All were treated with surgical excision. Microscopic examination revealed acanthotic squamous epithelium with papillomatosis. The subepithelial region had collections of lymphatic channels composed of ectatic dilated vessels with serum and inflammatory cells in their lumina. The lymphatic channels were seen in deeper layers along with lymphocytic aggregates.
  
  
  CONCLUSIONS
  Lymphangioma circumscriptum is a malformation of abnormal lymphatic channels with feeding cisterns in subcutaneous tissue. It is a benign lesion usually occurring in anal/perianal region and confused with warts. Surgical excision is preferred mode of treatment.
authors.affiliation: Department of Pathology and Microbiology, The Aga Khan UniversityHospital, Karachi.
authors.forename: Saira
authors.initials: S
authors.lastname: Fatima
authors.affiliation: Department of Pathology and Microbiology, The Aga Khan UniversityHospital, Karachi.
authors.forename: Nasir
authors.initials: N
authors.lastname: Uddin
authors.affiliation: Department of Pathology and Microbiology, The Aga Khan UniversityHospital, Karachi.
authors.forename: Romana
authors.initials: R
authors.lastname: Idrees
authors.affiliation: Department of Pathology and Microbiology, The Aga Khan UniversityHospital, Karachi.
authors.forename: Khurram
authors.initials: K
authors.lastname: Minhas
authors.affiliation: Department of Pathology and Microbiology, The Aga Khan UniversityHospital, Karachi.
authors.forename: Zubair
authors.initials: Z
authors.lastname: Ahmad
authors.affiliation: Department of Pathology and Microbiology, The Aga Khan UniversityHospital, Karachi.
authors.forename: Rashida
authors.initials: R
authors.lastname: Ahmad
authors.affiliation: Department of Pathology and Microbiology, The Aga Khan UniversityHospital, Karachi.
authors.forename: Naila
authors.initials: N
authors.lastname: Kayani
authors.affiliation: Department of Pathology and Microbiology, The Aga Khan UniversityHospital, Karachi.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Arif
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000453:epidemiology / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D005834:Genital Neoplasms, Male / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008202:Lymphangioma / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000453:epidemiology / Q000473:pathology; D010502:Perineum / Q000473:pathology; D012611:Scrotum / Q000473:pathology; D014062:Tongue Neoplasms / Q000453:epidemiology / Q000473:pathology*; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery