title: Dry Eye Treatment Based on Contact Lens Drug Delivery: A Review.
abstract: Dry eye disease affects a substantial segment of the word population with increasing frequency. It is a multifactorial disease of the ocular surface and tear film, which causes ocular discomfort, visual disturbances, and tear instability with potential damage to the cornea and conjunctiva. Because of its multifactorial etiology, the use of different pharmacological treatment for dry eye treatment has been proposed, which include anti-inflammatory molecules, lubricants or comfort agents, and secretagogues. However, in some cases these pharmacological approaches only relieve symptoms temporarily, and consequently, eye care professionals continue to have difficulties managing dry eye. To improve pharmacological therapy that allows a more efficient and long-term action, effective ocular drug delivery of the currently available drugs for dry eye treatment is required. Contact lenses are emerging as alternative ophthalmic drugs delivery systems that provide an increased residence time of the drug at the eye, thus leading to enhanced bioavailability and more convenient and efficacious therapy. In this article, we reviewed the different techniques used to prepare contact lens-based drug delivery systems and focused on articles that describe the delivery of compounds for dry eye treatment through contact lenses.
authors.affiliation: Department of Biochemistry and Molecular Biology IV (A.G.-A., B.F., A.M.-G., A.M.-A., J.P.), Faculty of Optic and Optometry, Universidad Complutense de Madrid, Madrid, Spain; and Department of Optics II (Optometry and Vision) (G.C.), Faculty of Optic and Optometry, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Guzman-Aranguez
authors.forename: Begoña
authors.initials: B
authors.lastname: Fonseca
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Carracedo
authors.forename: Alba
authors.initials: A
authors.lastname: Martin-Gil
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martinez-Aguila
authors.forename: Jesús
authors.initials: J
authors.lastname: Pintor
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001682:Biological Availability; D003228:Conjunctiva / Q000187:drug effects; D003261:Contact Lenses; D003315:Cornea / Q000187:drug effects; D015226:Dinucleoside Phosphates / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D015352:Dry Eye Syndromes / Q000188:drug therapy*; D006801:Humans; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D014906:Wetting Agents / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D015226:Dinucleoside Phosphates; D009883:Ophthalmic Solutions; D014906:Wetting Agents