title: Keeping It in the Family: ATRX Loss Promotes Persistent Sister Telomere Cohesion in ALT Cancer Cells.
abstract: In this issue of Cancer Cell, Ramamoorthy and Smith report that cancer cells that maintain their chromosome ends through alternative lengthening of telomeres (ALT) display persistent sister telomere cohesion. This delayed resolution of sister telomere cohesion depends upon the loss of ATRX and its histone-sequestering function and is associated with increased recombination between sister telomeres.
authors.affiliation: Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Caitlin M
authors.initials: CM
authors.lastname: Roake
authors.affiliation: Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: sartandi@stanford.edu.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Artandi
mesh_terms: D004265:DNA Helicases / Q000235:genetics*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D011995:Recombination, Genetic / Q000235:genetics*; D016615:Telomere / Q000235:genetics*
chemical_list: D009687:Nuclear Proteins; D004265:DNA Helicases