title: Osteoporotic risk and physeal closure in prepubertal ovariohysterectomized cats.
abstract: We aimed to examine the early effects of prepubertal ovariohysterectomy (P-OHE) on bone loss and proximal physeal closure in cats. Fourteen kittens randomly underwent P-OHE or sham operations (S-OP) at three months (mo) of age and were allocated to group I and group II. Each mo between four and nine mo of age, dual-energy X-ray absorptiometry (DEXA) scans were performed to determine the total body bone mineral density (BMD) and bone mineral content (BMC). Proximal radial physeal closure and radial length were determined by radiography. Bone-specific alkaline phosphatase (BAP), carboxy-terminal collagen teleopeptide (CTX), 17-β estradiol, progesterone, calcium (Ca) and phosphorus (P) were measured in the serum samples. No significant differences were observed between the groups in terms of BMD, BMC, BAP, BAP/CTX, P, progesterone and body weight (BW) (between 4 and 9mo) and for Ca (between 5 and 9mo) and for CTX levels (between 4 and 8mo). The 17-β estradiol was significantly higher at 6, 8 and 9mo of age in the S-OP group due to puberty (P=0.02, P=0.03 and P=0.02 respectively). Although there was a significant difference (P=0.0002) between the P-OHE and S-OP groups in terms of the proximal radial physeal closure times (7.43±0.20mo and 6.14±0.14mo, respectively), no significant difference was observed for the mean radius length (10.59±0.10cm and 10.06±0.27cm, respectively) at the last evaluation time. In conclusion, prepubertal ovariohysterectomized cats do not have any osteoporotic risks until nine mo of age and exhibit a delayed physeal closure time without a change in radius length.
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcılar, Istanbul, Turkey. Electronic address: dr_veterinarian@yahoo.com.
authors.forename: Melih
authors.initials: M
authors.lastname: Uçmak
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcılar, Istanbul, Turkey. Electronic address: turnaozge@hotmail.com.
authors.forename: Özge Turna
authors.initials: ÖT
authors.lastname: Yılmaz
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcılar, Istanbul, Turkey. Electronic address: mcg@istanbul.edu.tr.
authors.forename: Mehmet Can
authors.initials: MC
authors.lastname: Gündüz
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcılar, Istanbul, Turkey. Electronic address: vethek_zeynep@hotmail.com.
authors.forename: Zeynep Günay
authors.initials: ZG
authors.lastname: Uçmak
authors.affiliation: Department of Surgery, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcılar, Istanbul, Turkey. Electronic address: Oktay@istanbul.edu.tr.
authors.forename: Oktay
authors.initials: O
authors.lastname: Duzgun
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Istanbul University, 34093 Fatih, Istanbul, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Eskiyurt
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Istanbul University, 34093 Fatih, Istanbul, Turkey.
authors.forename: Coşkun Umut
authors.initials: CU
authors.lastname: Oruç
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Istanbul University, 34093 Fatih, Istanbul, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Genç
authors.affiliation: Institute of Health Sciences, Istanbul University, 34303 Kocamustafapaşa, Istanbul, Turkey. Electronic address: erzenginm@hotmail.com.
authors.forename: Ömer Mehmet
authors.initials: ÖM
authors.lastname: Erzengin
authors.affiliation: Institute of Health Sciences, Istanbul University, 34303 Kocamustafapaşa, Istanbul, Turkey. Electronic address: faith716@hotmail.com.
authors.forename: Esra
authors.initials: E
authors.lastname: Karaçam
mesh_terms: D015502:Absorptiometry, Photon / Q000662:veterinary; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002118:Calcium / Q000097:blood; D002371:Cat Diseases / Q000209:etiology*; D002415:Cats / Q000502:physiology / Q000601:surgery; D024042:Collagen Type I / Q000097:blood; D004958:Estradiol / Q000097:blood; D007044:Hysterectomy / Q000009:adverse effects / Q000662:veterinary*; D010024:Osteoporosis / Q000209:etiology / Q000662:veterinary*; D010052:Ovariectomy / Q000009:adverse effects / Q000662:veterinary*; D010455:Peptides / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011374:Progesterone / Q000097:blood; D011884:Radius / Q000254:growth & development; D012741:Sexual Maturation / Q000502:physiology
chemical_list: D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D010758:Phosphorus; D011374:Progesterone; D004958:Estradiol; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: Bone loss; Cat; DEXA; Physeal closure; Prepubertal ovariohysterectomy