title: The fracture mechanics of human bone: influence of disease and treatment.
abstract: Aging and bone diseases are associated with increased fracture risk. It is therefore pertinent to seek an understanding of the origins of such disease-related deterioration in bone's mechanical properties. The mechanical integrity of bone derives from its hierarchical structure, which in healthy tissue is able to resist complex physiological loading patterns and tolerate damage. Indeed, the mechanisms through which bone derives its mechanical properties make fracture mechanics an ideal framework to study bone's mechanical resistance, where crack-growth resistance curves give a measure of the intrinsic resistance to the initiation of cracks and the extrinsic resistance to the growth of cracks. Recent research on healthy cortical bone has demonstrated how this hierarchical structure can develop intrinsic toughness at the collagen fibril scale mainly through sliding and sacrificial bonding mechanisms that promote plasticity. Furthermore, the bone-matrix structure develops extrinsic toughness at much larger micrometer length-scales, where the structural features are large enough to resist crack growth through crack-tip shielding mechanisms. Although healthy bone tissue can generally resist physiological loading environments, certain conditions such as aging and disease can significantly increase fracture risk. In simple terms, the reduced mechanical integrity originates from alterations to the hierarchical structure. Here, we review how human cortical bone resists fracture in healthy bone and how changes to the bone structure due to aging, osteoporosis, vitamin D deficiency and Paget's disease can affect the mechanical integrity of bone tissue.
authors.affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf , Hamburg, Germany.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Zimmermann
authors.affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf , Hamburg, Germany.
authors.forename: Björn
authors.initials: B
authors.lastname: Busse
authors.affiliation: Materials Sciences Division, Lawrence Berkeley National Laboratory , Berkeley, CA, USA ; Department of Materials Science & Engineering, University of California , Berkeley, CA, USA.
authors.forename: Robert O
authors.initials: RO
authors.lastname: Ritchie