title: Auditory Impairment in Young Type 1 Diabetics.
abstract: OBJECTIVE
  More attention has recently been focused on auditory impairment of young type 1 diabetics. This study aimed to evaluate auditory function of young type 1 diabetics and the correlation between clinical indexes and hearing impairment.
  
  
  METHODS
  We evaluated the auditory function of 50 type 1 diabetics and 50 healthy subjects. Clinical indexes were measured along with analyzing their relation of auditory function.
  
  
  RESULTS
  Type 1 diabetic patients demonstrated a deficit with elevated thresholds at right ear and left ear when compared to healthy controls (p <0.01). The elevated auditory threshold was significantly related with HDL-cholesterol, diabetes duration, and systemic blood pressure (p <0.05). Moreover, latencies of right ear (wave III, V and interwave I-V) and left ear (wave III, V and interwave I-III, I-V) in diabetic group significantly increased compared to those in control subjects (p <0.01). Auditory brainstem response was significantly related with GHbA1C and microalbuminuria (p <0.01). Furthermore, distortion product evoked otoacoustic emissions (DPOAE) of diabetes group were statistically significant in right ears at 4.0, 6.0 kHz and in left ears at 4.0, 6.0, 8.0 kHz (p <0.01) compared with those of controls. Diabetic patients demonstrated lower amplitude responses of the right ear than the left ear at 8.0 kHz. Only triglyceride was positively correlated to the hearing impairment defined by DPOAE (p <0.01). There was no significance of transient evoked otoacoustic emissions (TEOAE) between groups. TEOAE was associated with age and GHbA1C (p <0.01).
  
  
  CONCLUSIONS
  Type 1 diabetics exerted higher auditory threshold, slower auditory conduction time and cochlear impairment. HDL-cholesterol, diabetes duration, systemic blood pressure, microalbuminuria, GHbA1C, triglyceride, and age may affect the auditory function of type 1 diabetics.
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China; Affiliated Hospital of Taishan Medical University, Taian, Shandong Province, China.
authors.forename: Yanlian
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China. Electronic address: xiaoyanxiao2007@163.com.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Endocrinology, Jinan Central Hospital, Jinan, China.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Faming
authors.initials: F
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000652:urine; D001309:Auditory Threshold / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood; D003051:Cochlea / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006309:Hearing / Q000502:physiology; D034381:Hearing Loss / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D014280:Triglycerides; C517652:hemoglobin A1c protein, human
keywords: Auditory brainstem response; Hearing impairment; Otoacoustic emissions; Type 1 diabetes