title: Contactin 1: A potential therapeutic target and biomarker in gastric cancer.
abstract: Despite advances in diagnosis and treatment, gastric cancer remains one of the most common malignant tumors worldwide, and early diagnosis remains a challenge. The lack of effective methods to detect these tumors early is a major factor contributing to the high mortality in patients with gastric cancer, who are typically diagnosed at an advanced stage. Additionally, the early detection of metastases and the curative treatment of gastric cancer are difficult to achieve, and the detailed mechanisms remain to be fully elucidated. Thus, the identification of valuable predictive biomarkers and therapeutic targets to improve the prognosis of patients with gastric cancer is becoming increasingly important. Contactin 1 (CNTN1), a cell adhesion molecule, is a glycosylphosphatidylinositol-anchored neuronal membrane protein that plays an important role in cancer progression. The expression of CNTN1 is upregulated in primary lesions, and its expression level correlates with tumor metastasis in cancer patients. The current evidence reveals that the functions of CNTN1 in the development and progression of cancer likely promote the invasion and metastasis of cancer cells via the VEGFC/FLT4 axis, the RHOA-dependent pathway, the Notch signaling pathway and the epithelial-mesenchymal transition progression. Therefore, CNTN1 may be a novel biomarker and a possible therapeutic target in cancer treatment in the near future.
authors.affiliation: De-Hu Chen, Ji-Wei Yu, Bo-Jian Jiang, Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China.
authors.forename: De-Hu
authors.initials: DH
authors.lastname: Chen
authors.affiliation: De-Hu Chen, Ji-Wei Yu, Bo-Jian Jiang, Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China.
authors.forename: Ji-Wei
authors.initials: JW
authors.lastname: Yu
authors.affiliation: De-Hu Chen, Ji-Wei Yu, Bo-Jian Jiang, Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China.
authors.forename: Bo-Jian
authors.initials: BJ
authors.lastname: Jiang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors / Q000378:metabolism*; D058967:Contactin 1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D011237:Predictive Value of Tests; D011379:Prognosis; D015398:Signal Transduction / Q000187:drug effects; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C548669:CNTN1 protein, human; D058967:Contactin 1
keywords: Cancer/neoplasms; Contactin 1; Metastasis; Molecular target; Stomach