title: Review: in vitro microvessel models.
abstract: A wide range of perfusable microvessel models have been developed, exploiting advances in microfabrication, microfluidics, biomaterials, stem cell technology, and tissue engineering. These models vary in complexity and physiological relevance, but provide a diverse tool kit for the study of vascular phenomena and methods to vascularize artificial organs. Here we review the state-of-the-art in perfusable microvessel models, summarizing the different fabrication methods and highlighting advantages and limitations.
authors.affiliation: Institute for Nanobiotechnology (INBT), 100 Croft Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, Maryland 21218, USA. searson@jhu.edu.
authors.forename: Max I
authors.initials: MI
authors.lastname: Bogorad
authors.affiliation: Institute for Nanobiotechnology (INBT), 100 Croft Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, Maryland 21218, USA. searson@jhu.edu.
authors.forename: Jackson
authors.initials: J
authors.lastname: DeStefano
authors.affiliation: Institute for Nanobiotechnology (INBT), 100 Croft Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, Maryland 21218, USA. searson@jhu.edu.
authors.forename: Johan
authors.initials: J
authors.lastname: Karlsson
authors.affiliation: Institute for Nanobiotechnology (INBT), 100 Croft Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, Maryland 21218, USA. searson@jhu.edu.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Wong
authors.affiliation: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors.forename: Sharon
authors.initials: S
authors.lastname: Gerecht
authors.affiliation: Institute for Nanobiotechnology (INBT), 100 Croft Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, Maryland 21218, USA. searson@jhu.edu and Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Searson
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000166:cytology*; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D008954:Models, Biological