title: Prognostic and Clinicopathological Value of Survivin in Diffuse Large B-cell Lymphoma: A Meta-Analysis.
abstract: Up to date, survivin, a well-known inhibitor of apoptosis, has attracted considerable attention as a potential biomarker and therapeutic target in diffuse large B-cell lymphoma (DLBCL). Nevertheless, there still remains no consensus on heterogeneous results. Herein, a meta-analysis was performed to clarify a convincing significance of survivin status on prognosis and clinicopathology of DLBCL patients.Eligible studies were identified by searching Medline, Embase, Scopus, CNKI, and Wanfang databases (last updated on November 30, 2014). Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Heterogeneity and sensitivity were also analyzed. Moreover, Begg, Egger test, and funnel plots were applied to evaluate the publication bias.We finally included 17 eligible studies with the total number of 1352 patients in the meta-analysis. The pooled results showed that positive survivin expression in DLBCL was associated with inferior overall survival (OS) (HR: 1.880, 95% CI: 1.550-2.270) in patients. Moreover, a significant association was revealed between survivin expression and advanced clinical stage (III + IV) (OR: 0.611, 95% CI: 0.452-0.827), higher International Prognosis Index (IPI) score (Score 3-5) (OR: 0.559; 95% CI: 0.410-0.761), elevated serum lactic dehydrogenase (LDH) (OR: 0.607, 95% CI: 0.444-0.831), presence of bone marrow involvement (OR: 2.127, 95% CI: 1.154-3.921) together with reduced complete remission (CR) rate (OR: 0.478, 95% CI: 0.345-0.662).The results suggest that survivin could be a useful prognostic biomarker, and a promising target for DLBCL therapeutic intervention. Considering limited HR data adjusted for standard prognostic variables could be retrieved, future high-quality studies will be needed in evaluating the independent prognostic value of survivin expression in DLBCL.
authors.affiliation: From the Department of Hematology, Shandong Provincial Hospital affiliated to Shandong University (YZ, JW, XS, YL, KL, XF, YJ, XW); and Institute of Diagnostics, Shandong University School of Medicine, Jinan, Shandong, P.R. China (XW).
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianhong
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Sui
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Kang
authors.initials: K
authors.lastname: Lu
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: Fang
authors.forename: Yujie
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000032:analysis / Q000235:genetics; D015415:Biomarkers / Q000032:analysis; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm; D015870:Gene Expression; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000032:analysis / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D000077022:Survivin
chemical_list: D051017:Apoptosis Regulatory Proteins; C107489:BIRC5 protein, human; D015415:Biomarkers; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins; D000077022:Survivin