title: Control-related frontal-striatal function is associated with past suicidal ideation and behavior in patients with recent-onset psychotic major mood disorders.
abstract: OBJECTIVE
  Suicide is highly-prevalent in major mood disorders, yet it remains unclear how suicidal ideation and suicidal behavior relate to brain functions, especially those that support control processes. We evaluated how prefrontal cortex (PFC) activity during goal-representation (an important component of cognitive control) relates to past suicidal ideation and behavior in patients with psychotic major mood disorders.
  
  
  METHODS
  30 patients with recent-onset of either DSM-IV-TR-defined bipolar disorder type I (n=21) or major depressive disorder (n=9) with psychotic features, but neither in a major mood episode nor acutely psychotic at study, were evaluated for past suicidal ideation and behavior (Columbia Suicide Severity Rating Scale) and functional MRI during cognitive control task performance. Group-level regression models of brain activation accounted for current depression, psychosis and trait impulsivity.
  
  
  RESULTS
  Intensity of past suicidal ideation was associated with higher control-related activation in right-hemisphere regions including the ventrolateral PFC (VLPFC) and orbitofrontal cortex, rostral insula, and dorsal striatum. Among those with past suicidal ideation (n=16), past suicidal behavior (n=8) was associated with higher control-related activation in right-hemisphere regions including VLPFC, rostrolateral PFC, and frontal operculum/rostral insula; and relatively lower activity in midline parietal regions, including cuneus and precuneus.
  
  
  CONCLUSIONS
  The sample size of subjects with past suicidal behavior was modest, and all subjects were taking psychotropic medication.
  
  
  CONCLUSIONS
  This study provides unique evidence that in early-course psychotic major mood disorders, suicidal ideation and behavior histories directly relate to PFC-based circuit function in support of cognitive control.
authors.affiliation: Department of Psychiatry, University of California, San Francisco School of Medicine, and Veterans Affairs Medical Center, San Francisco, CA, USA. Electronic address: Michael.minzenberg@ucsf.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Minzenberg
authors.affiliation: Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA.
authors.forename: Tyler A
authors.initials: TA
authors.lastname: Lesh
authors.affiliation: Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA.
authors.forename: Tara A
authors.initials: TA
authors.lastname: Niendam
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, and the VA Palo Alto Health Care System, Palo Alto, CA, USA.
authors.forename: Jong H
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Psychiatry, University of California, San Francisco School of Medicine, and Veterans Affairs Medical Center, San Francisco, CA, USA.
authors.forename: Yaoan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, and the VA Palo Alto Health Care System, Palo Alto, CA, USA.
authors.forename: Remy N
authors.initials: RN
authors.lastname: Rhoades
authors.affiliation: Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA; Center for Neuroscience, University of California, Davis, CA, USA.
authors.forename: Cameron S
authors.initials: CS
authors.lastname: Carter
mesh_terms: D000341:Affective Disorders, Psychotic / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017072:Neostriatum / Q000503:physiopathology*; D012307:Risk Factors; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000523:psychology*; D055815:Young Adult
keywords: Bipolar I disorder; Cognitive control; Frontal cortex; Major depressive disorder; Psychosis; Suicide risk