title: Structure and Antibacterial Activity of Ambobactin, a New Telomycin-Like Cyclic Depsipeptide Antibiotic Produced by Streptomyces ambofaciens F3.
abstract: A new telomycin-like cyclic depsipeptide, ambobactin (1), was isolated from the metabolites of Streptomyces ambofaciens F3, an endophyte of Platycladus orientalis. Its structure was elucidated on the basis of extensive spectroscopic analysis and advanced Marfey's method. Ambobactin is structurally related with telomycin, except that the configuration of the 3-methyltryptophanes in their structures is different. It exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria. Furthermore, this investigation revealed that S. ambofaciens F3 is a new producer of telomycin-like antibiotics.
authors.affiliation: College of Plant Protection, Northwest A & F University, Yangling 712100, Shanxi, China. weishaopeng@nwsuaf.edu.cn.
authors.forename: Shaopeng
authors.initials: S
authors.lastname: Wei
authors.affiliation: College of Plant Protection, Northwest A & F University, Yangling 712100, Shanxi, China. zhangwenhao@nwsuaf.edu.cn.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Zhang
authors.affiliation: College of Plant Protection, Northwest A & F University, Yangling 712100, Shanxi, China. jizhiqin@nwsuaf.edu.cn.
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Ji
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D010456:Peptides, Cyclic; C009392:telomycin
keywords: Streptomyces ambofaciens F3; antibacterial activity; cyclic depsipeptide; telomycin-like