title: Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children.
abstract: The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.
authors.affiliation: Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
authors.forename: Regis W
authors.initials: RW
authors.lastname: Tiendrebeogo
authors.affiliation: Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
authors.forename: Bright
authors.initials: B
authors.lastname: Adu
authors.affiliation: Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
authors.forename: Susheel K
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Blood Bank KI 2034, Copenhagen University Hospital , Denmark.
authors.forename: Morten H
authors.initials: MH
authors.lastname: Dziegiel
authors.affiliation: Centre National de Recherche et de Formation sur le Paludisme , Ouagadougou , Burkina Faso.
authors.forename: Issa
authors.initials: I
authors.lastname: Nébié
authors.affiliation: Centre National de Recherche et de Formation sur le Paludisme , Ouagadougou , Burkina Faso.
authors.forename: Sodiomon B
authors.initials: SB
authors.lastname: Sirima
authors.affiliation: Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen.
authors.forename: Michael
authors.initials: M
authors.lastname: Christiansen
authors.affiliation: Noguchi Memorial Institute for Medical Research , University of Ghana , Legon.
authors.forename: Daniel
authors.initials: D
authors.lastname: Dodoo
authors.affiliation: Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
authors.forename: Michael
authors.initials: M
authors.lastname: Theisen
keywords: Plasmodium falciparum; antibody-dependent cellular inhibition; children; longitudinal cohort study; malaria; monocytes