title: The effect of 25(OH)D on endothelial and immunological markers in Behçet's disease.
abstract: BACKGROUND
  Endothelial selectine molecules (ESMs) and Toll-like receptors (TLRs) were suggested to be associated with the pathogenesis of Behçet's disease (BD). 25(OH)D deficiency may be associated with endothelial and immune dysfunction. The aim of this study is to investigate the relationship between the 25(OH)D level, and ESMs and TLRs in BD patients.
  
  
  METHODS
  BD patients were classified as 25(OH)D deficient (Group 1) and sufficient (Group 2) groups. Vitamin D replacement therapy was given to Group 1, after the last replacement dose blood was again collected. ESMs and TLRs levels were evaluated and compared both between Group 1 and Group 2, and pre- and post-treatment measurements of Group 1.
  
  
  RESULTS
  The baseline plasma levels of ESMs were significantly higher in Group 1 than in Group 2 (p < 0.05). There were not any significant differences in baseline TLRs levels between Group 1 and Group 2. The mean plasma levels of ESMs were significantly lower in post-replacement assessments (p < 0.05). The mean plasma levels of TLRs were lower in post-replacement assessments, but not significantly (p > 0.05). The active stage disease rate was higher in pre-treatment group (36.3%) than post-treatment group (34.6%), but the difference was not significant (p > 0.05).
  
  
  CONCLUSIONS
  Although vitamin D replacement in 25(OH)D deficient BD patients may have some beneficial effects on vascular dysfunction, it cannot be considered the primary treatment modality.
authors.affiliation: a Dermatology Department, Okmeydanı Training and Research Hospital , Istanbul , Turkey .
authors.forename: Şule
authors.initials: Ş
authors.lastname: Güngör
authors.affiliation: b Dermatology Department, Bahçeşehir University School of Medicine , Istanbul , Turkey .
authors.forename: Gonca
authors.initials: G
authors.lastname: Gökdemir
authors.affiliation: c Clinical Biochemistry, Okmeydanı Training and Research Hospital , Istanbul , Turkey , and.
authors.forename: Yüksel Gülen
authors.initials: YG
authors.lastname: Çiçek
authors.affiliation: a Dermatology Department, Okmeydanı Training and Research Hospital , Istanbul , Turkey .
authors.forename: İlteriş Oğuz
authors.initials: İO
authors.lastname: Topal
authors.affiliation: d Dermatology Department, Esenyurt Hospital , Istanbul , Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Canat
mesh_terms: D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000097:blood / Q000188:drug therapy*; D015415:Biomarkers / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D019040:E-Selectin / Q000097:blood*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051193:Toll-Like Receptors / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy*
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D051193:Toll-Like Receptors; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Behçet’s disease; E-selectine; ICAM; P-selectine; TLR-2; TLR-4; VCAM; selectine molecules; vitamin D