title: Status of vitamin D, antioxidant enzymes, and antioxidant substances in neonates with neonatal hypoxic-ischemic encephalopathy.
abstract: OBJECTIVE
  To investigate the concentration of vitamin D (VD), glutathione peroxidase (GP), superoxide dismutase (SOD), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) in neonates with hypoxic-ischemic encephalopathy (HIE).
  
  
  METHODS
  This study was performed prospectively in term neonates treated for HIE. Samples were collected from the neonates in study and control groups at 6-14 h and on day 5 of their lives for 25-OH vitamin D3, antioxidant enzymes including GP and SOD and oxidants substances including MDA and AOPP.
  
  
  RESULTS
  This study was performed with 31 term neonates with HIE and 30 healthy term neonates. Maternal VD level was statistically lower in the study group (9.8 ± 6.8 ng/mL) than the control (16.4 ± 8.7 ng/mL) (p = 0.002). SOD and MDA levels were significantly high, and VD level was significantly low in the study group on the first day of life (p = 0.001 and p = 0.028, respectively). SOD and GP levels were significantly high in the study group on day 5 (p < 0.05). VD was significantly low in the study group on day 5 and the proportion of subjects with VD below 5 ng/ml was significantly lower in the control group (p= <0.05).
  
  
  CONCLUSIONS
  VD has neuroprotective and antioxidant properties. We detected VD levels were low in infants with HIE and their mothers. This finding may be useful for decreasing of brain damage.
authors.affiliation: a Division of Neonatology, Department of Pediatrics , Karadeniz Technical University , Trabzon , Turkey .
authors.forename: Mehmet
authors.initials: M
authors.lastname: Mutlu
authors.affiliation: a Division of Neonatology, Department of Pediatrics , Karadeniz Technical University , Trabzon , Turkey .
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sarıaydın
authors.affiliation: a Division of Neonatology, Department of Pediatrics , Karadeniz Technical University , Trabzon , Turkey .
authors.forename: Yakup
authors.initials: Y
authors.lastname: Aslan
authors.affiliation: a Division of Neonatology, Department of Pediatrics , Karadeniz Technical University , Trabzon , Turkey .
authors.forename: Şebnem
authors.initials: Ş
authors.lastname: Kader
authors.affiliation: b Department of Pediatrics , Recep Tayyip Erdoğan University , Rize , Turkey .
authors.forename: Selim
authors.initials: S
authors.lastname: Dereci
authors.affiliation: c Department of Obstetrics and Gynaecology , Karadeniz Technical University , Trabzon , Turkey , and.
authors.forename: Cavit
authors.initials: C
authors.lastname: Kart
authors.affiliation: d Department of Biochemistry , Karadeniz Technical University , Trabzon , Turkey.
authors.forename: Serap Özer
authors.initials: SÖ
authors.lastname: Yaman
authors.affiliation: d Department of Biochemistry , Karadeniz Technical University , Trabzon , Turkey.
authors.forename: Bilgül
authors.initials: B
authors.lastname: Kural
mesh_terms: D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood*; D016022:Case-Control Studies; D002762:Cholecalciferol / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood*; D007231:Infant, Newborn; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D011446:Prospective Studies; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D062107:Advanced Oxidation Protein Products; D002762:Cholecalciferol; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Advanced oxidation protein products; glutathione peroxidase; hypoxic-ischemic encephalopathy; malondialdehyde; superoxide dismutase; vitamin D