title: Specificity of vascular endothelial growth factor treatment for radiation necrosis.
abstract: Recently, radiation induced necrosis in the brain has been treated using bevacizumab, an anti-VEGF antibody. We validated the VEGF specificity by comparing the therapeutic efficacy of anti-VEGF with non-specific isotype control antibody. Additionally, we found that VEGF over-expression and RN developed simultaneously, which precludes preventative anti-VEGF treatment.
authors.affiliation: Department of Radiology, Washington University, Saint Louis, United States.
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Perez-Torres
authors.affiliation: Department of Neurosurgery, Washington University, Saint Louis, United States.
authors.forename: Liya
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Neuropathology, Washington University, Saint Louis, United States.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Schmidt
authors.affiliation: Department of Neurosurgery, Washington University, Saint Louis, United States; Department of Radiation Oncology, Washington University, Saint Louis, United States.
authors.forename: Keith M
authors.initials: KM
authors.lastname: Rich
authors.affiliation: Department of Neurosurgery, Washington University, Saint Louis, United States; Department of Radiation Oncology, Washington University, Saint Louis, United States.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Drzymala
authors.affiliation: Department of Radiation Oncology, Washington University, Saint Louis, United States; The Alvin J. Siteman Cancer Center, Washington University, Saint Louis, United States.
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Hallahan
authors.affiliation: Department of Radiology, Washington University, Saint Louis, United States; Department of Chemistry, Washington University, Saint Louis, United States; Department of Internal Medicine, Washington University, Saint Louis, United States; The Alvin J. Siteman Cancer Center, Washington University, Saint Louis, United States.
authors.forename: Joseph J H
authors.initials: JJ
authors.lastname: Ackerman
authors.affiliation: Department of Radiology, Washington University, Saint Louis, United States; The Alvin J. Siteman Cancer Center, Washington University, Saint Louis, United States. Electronic address: garbow@wustl.edu.
authors.forename: Joel R
authors.initials: JR
authors.lastname: Garbow
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology* / Q000528:radiation effects*; D004195:Disease Models, Animal; D005260:Female; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis / Q000188:drug therapy; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D012680:Sensitivity and Specificity; D042461:Vascular Endothelial Growth Factor A / Q000627:therapeutic use*
chemical_list: D042461:Vascular Endothelial Growth Factor A
keywords: Magnetic resonance imaging; Radiation necrosis; Vascular endothelial growth factor