title: A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells.
abstract: Adaptive immunity critically depends on the functional compartmentalization of secondary lymphoid organs. Mesenchymal stromal cells create and maintain specialized niches that support survival, activation, and expansion of T and B cells, and integrated analysis of lymphocytes and their niche has been instrumental in understanding adaptive immunity. Lymphoid organs are also home to type 3 innate lymphoid cells (ILC3), innate effector cells essential for barrier immunity. However, a specialized stromal niche for ILC3 has not been identified. A novel lineage-tracing approach now identifies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult marginal reticular cells. Moreover, both cell types are conserved from mice to humans and colocalize with ILC3 in secondary lymphoid tissues throughout life. In sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells and form a dedicated stromal niche for innate ILC3 in adaptive lymphoid organs.
authors.affiliation: Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Kerim
authors.initials: K
authors.lastname: Hoorweg
authors.affiliation: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York, UK.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Narang
authors.affiliation: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York, UK.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.affiliation: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Thuery
authors.affiliation: Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Natalie
authors.initials: N
authors.lastname: Papazian
authors.affiliation: Medical Research Council Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, Birmingham, U.K.
authors.forename: David R
authors.initials: DR
authors.lastname: Withers
authors.affiliation: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York, UK.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Coles
authors.affiliation: Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Tom
authors.initials: T
authors.lastname: Cupedo
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000235:genetics / Q000276:immunology; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000166:cytology; D005434:Flow Cytometry; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D008822:Mice, Transgenic; D018613:Microscopy, Confocal; D053245:RANK Ligand / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055153:Stem Cell Niche / Q000235:genetics / Q000276:immunology*; D017154:Stromal Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D018925:Chemokines; D053245:RANK Ligand; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1