title: Outcome of the Respiratory Syncytial Virus related acute lower respiratory tract infection among hospitalized newborns: a prospective multicenter study.
abstract: OBJECTIVE
  To determine the incidence and outcomes of respiratory syncytial virus (RSV)-related acute lower respiratory tract infection (ALRI) including morbidity, nosocomial infection and mortality among newborn infants who were admitted to the neonatal intensive care units (NICUs).
  
  
  METHODS
  A multicenter, prospective study was conducted in newborns who were hospitalized with community acquired or nosocomial RSV infection in 44 NICUs throughout Turkey. Newborns with ALRI were screened for RSV infection by Respi-Strip®-test. Main outcome measures were the incidence of RSV-associated admissions in the NICUs and morbidity, mortality and epidemics results related to these admissions.
  
  
  RESULTS
  The incidence of RSV infection was 1.24% (n: 250) and RSV infection constituted 19.6% of all ALRI hospitalizations, 226 newborns (90.4%) had community-acquired whereas 24 (9.6%) patients had nosocomial RSV infection in the NICUs. Of the 250 newborns, 171 (68.4%) were full-term infants, 183 (73.2%) had a BW >2500 g. RSV-related mortality rate was 1.2%. Four NICUs reported seven outbreaks on different months, which could be eliminated by palivizumab prophylaxis in one NICU.
  
  
  CONCLUSIONS
  RSV-associated ALRI both in preterm and term infants accounts an important percent of hospitalizations in the season, and may threat other high-risk patients in the NICU.
authors.affiliation: a Neonatal Intensive Care Unit, Hitit University Corum Training and Research Hospital , Corum , Turkey .
authors.forename: Serdar
authors.initials: S
authors.lastname: Alan
authors.affiliation: b Division of Neonatology, Department of Pediatrics , Ankara University School of Medicine , Ankara , Turkey .
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.affiliation: b Division of Neonatology, Department of Pediatrics , Ankara University School of Medicine , Ankara , Turkey .
authors.forename: Ufuk
authors.initials: U
authors.lastname: Cakir
authors.affiliation: b Division of Neonatology, Department of Pediatrics , Ankara University School of Medicine , Ankara , Turkey .
authors.forename: Hasan
authors.initials: H
authors.lastname: Akduman
authors.affiliation: c Neonatal Intensive Care Unit, Dr Sami Ulus Maternity and Children Training and Research Hospital , Ankara , Turkey .
authors.forename: Aysegul
authors.initials: A
authors.lastname: Zenciroglu
authors.affiliation: d Division of Neonatology, Department of Pediatrics , Akdeniz University Medical School , Antalya , Turkey .
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akcakus
authors.affiliation: e Division of Neonatology, Department of Pediatrics , Gulhane Military School of Medicine , Ankara , Turkey .
authors.forename: Turan
authors.initials: T
authors.lastname: Tunc
authors.affiliation: f Neonatal Intensive Care Unit, Konya Training and Research Hospital , Konya , Turkey , and.
authors.forename: Zeynel
authors.initials: Z
authors.lastname: Gokmen
authors.affiliation: g Department of Biostatistics , Ankara University School of Medicine , Ankara , Turkey.
authors.forename: Can
authors.initials: C
authors.lastname: Ates
authors.affiliation: b Division of Neonatology, Department of Pediatrics , Ankara University School of Medicine , Ankara , Turkey .
authors.forename: Begum
authors.initials: B
authors.lastname: Atasay
authors.affiliation: b Division of Neonatology, Department of Pediatrics , Ankara University School of Medicine , Ankara , Turkey .
authors.forename: Saadet
authors.initials: S
authors.lastname: Arsan
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D003428:Cross Infection / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D007363:Intensive Care Units, Neonatal; D008297:Male; D000069455:Palivizumab / Q000627:therapeutic use; D011379:Prognosis; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D012136:Respiratory Syncytial Viruses; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents; D000069455:Palivizumab
keywords: Neonatal intensive care unit; newborn; nosocomial; outbreak; respiratory syncytial virus