title: Cutaneous adverse reactions specific to epidermal growth factor receptor inhibitors.
abstract: Classical antineoplastic therapy is encumbered by extensively studied adverse reactions, most often of systemic nature. The emergence of new generations of anticancer treatments, including epidermal growth factor receptor inhibitors, besides improving the response to treatment and the survival rate, is accompanied by the occurrence of new specific side effects, incompletely studied. These side effects are most often cutaneous (hand foot syndrome, acneiform reactions), and in some cases are extremely severe, requiring dose reduction or drug discontinuation. The prevention of the cutaneous adverse effects and their treatment require a close collaboration between the oncologist and the dermatologist. The occurrence of some of these skin adverse effects may be a favorable prognostic factor for the response to the cancer treatment and the overall survival.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: I
authors.initials: I
authors.lastname: Lupu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Department of Dermatology, "Elias" University Hospital, Bucharest, Romania.
authors.forename: V M
authors.initials: VM
authors.lastname: Voiculescu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: N
authors.initials: N
authors.lastname: Bacalbasa
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: B E
authors.initials: BE
authors.lastname: Prie
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: I
authors.initials: I
authors.lastname: Cojocaru
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Department of Dermatology, "Elias" University Hospital, Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Giurcaneanu
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000473:pathology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D006801:Humans; D012867:Skin / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D066246:ErbB Receptors
keywords: cutaneous adverse reactions; inhibitors of the EGF receptors; oncology