title: EMT-Inducing Molecular Factors in Gynecological Cancers.
abstract: Gynecologic cancers are the unregulated growth of neoplastic cells that arise in the cervix, ovaries, fallopian tubes, uterus, vagina, and vulva. Although gynecologic cancers are characterized by different signs and symptoms, studies have shown that they share common risk factors, such as smoking, obesity, age, exposure to certain chemicals, infection with human immunodeficiency virus (HIV), and infection with human papilloma virus (HPV). Despite recent advancements in the preventative, diagnostic, and therapeutic interventions for gynecologic cancers, many patients still die as a result of metastasis and recurrence. Since mounting evidence indicates that the epithelial-mesenchymal transition (EMT) process plays an essential role in metastatic relapse of cancer, understanding the molecular aberrations responsible for the EMT and its underlying signaling should be given high priority in order to reduce cancer morbidity and mortality.
authors.affiliation: Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA ; Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
authors.forename: Loredana
authors.initials: L
authors.lastname: Campo
authors.affiliation: Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA ; Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Breuer
mesh_terms: D000818:Animals; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology* / Q000821:virology; D006176:Gynecology / Q000379:methods; D006678:HIV / Q000472:pathogenicity; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000472:pathogenicity