title: Analysis of diterpenoid compounds from the latex of two Euphorbiaceae by liquid chromatography‒electrospray ionisation mass spectrometry.
abstract: The latex of Euphorbia papillosa A.St.-Hil. and Sapium glandulosum (L.) Morong was phytochemically investigated by liquid chromatography/mass spectrometry. The results reveal the presence of tigliane-type diterpenoid compounds, particularly 12-deoxyphorbol esters, in both species. In addition, ingenane-type diterpene esters were found in the latex of E. papillosa. The latex of S. glandulosum showed only tigliane-type diterpenes, confirming the literature data on this genus. According to mass data, we are proposing the presence of 10 compounds derived from 12-deoxyphorbol monoesters and diesters, from one 12-deoxyphorbaldehyde, from two ingenol derivatives and from one nitrogen-containing phorbol ester in the latex of the analysed species. Considering that 12-deoxy tigliane diterpenes are described as antitumour and antiviral agents, these results indicate a pharmacological potential for these two Euphorbiaceae species.
authors.affiliation: a Institute of Biological Sciences, Universidade de Passo Fundo , Passo Fundo , Brazil.
authors.forename: A M
authors.initials: AM
authors.lastname: Sobottka
authors.affiliation: b Institute of Pharmacy, Free University of Berlin , Berlin , Germany.
authors.forename: C
authors.initials: C
authors.lastname: Görick
authors.affiliation: b Institute of Pharmacy, Free University of Berlin , Berlin , Germany.
authors.forename: M F
authors.initials: MF
authors.lastname: Melzig
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D004224:Diterpenes / Q000032:analysis*; D019665:Euphorbiaceae / Q000737:chemistry*; D007840:Latex / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D004224:Diterpenes; D007840:Latex
keywords: Euphorbia papillosa; Sapium glandulosum; ingenane; phorbol esters; tigliane