title: T2MR and T2Candida: novel technology for the rapid diagnosis of candidemia and invasive candidiasis.
abstract: Candidemia and other forms of invasive candidiasis pose a significant diagnostic challenge. In order to provide the best treatment, it is important to accurately detect the fungal infection and identify the species. Historically, diagnosis of Candida infections depended upon three classical laboratory approaches: microbiologic, immunologic, histopathologic; and now includes new methods such as radiographic techniques, molecular, proteomic and biochemical methods. The T2Candida Panel has introduced a new class of infectious disease diagnostics that can rapidly detect and identify the causative pathogen of sepsis directly from a patient blood sample in a culture-independent manner. This test enables detection of Candida directly from the patient sample, a significant advance for the rapid and accurate diagnosis of invasive candidiasis.
authors.affiliation: T2 Biosystems, 101 Hartwell Ave, Lexington, MA 02421, USA.|University of Iowa College of Medicine & College of Public Health, Iowa City, IA, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pfaller
authors.affiliation: Geisinger Health Systems, Danville, PA, USA.
authors.forename: Donna M
authors.initials: DM
authors.lastname: Wolk
authors.affiliation: T2 Biosystems, 101 Hartwell Ave, Lexington, MA 02421, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Lowery
mesh_terms: D001769:Blood / Q000382:microbiology*; D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D058365:Candidiasis, Invasive / Q000175:diagnosis* / Q000382:microbiology*; D003955:Diagnostic Tests, Routine / Q000379:methods*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008828:Microbiological Techniques / Q000379:methods*; D013672:Technology; D013997:Time Factors
keywords: Candida; T2Candida; T2MR; blood stream infection; diagnosis; magnetic resonance; nanotechnology; sepsis