title: Clinical characteristics of patients with malignancies combined with acute kidney injury.
abstract: OBJECTIVE
  To analyze clinical characteristics and prognostic factors of patients with malignancies combined with acute kidney injury (AKI), providing a basis for clinical AKI prevention and prognosis improvement.
  
  
  METHODS
  Hospitalized patients in the Central Hospital of Nephrology from January 2008 to December 2013 were screened by electronic medical record system; Statistical analysis formalignant tumor patients associated with AKI was conducted. The clinical features of these patients in 6 years were analyzed and compared, and Logistic regression analysis was used to analyze the risk factors of hospitalized mortality in patients with and malignant tumor and AKI.
  
  
  RESULTS
  There were 340 cases of malignancies associated with AKI patients, accounting for 30.0% (340/1133) of AKI patients in the same period. In malignancy patients, hematological malignancies accounted for 12.9% (44/340); non-metastatic solid tumor accounted for 54.7% (186/340); metastatic solid tumor accounted for 32.4% (110/340). In factors leading to AKI, post-renal obstruction [60% (204/340)], nephrotoxic drugs or contrast agents [27.9% (95/340)] and hypovolemia [41/340 (12.1%)] were common in patients with malignant tumors. There was no significant difference in the cause of AKI between early 3 years and later 3 years (P>0.05). Hospital mortality in patients with malignancies associated with AKI was [22.9% (78/340)], with an annually declining trend. Multivariate Logistic regression showed that: multiple etiologies, multiple organ failure, metastatic solid tumor, sepsis, and continuous renal replacement therapy were independent risk factors for hospital mortality.
  
  
  CONCLUSIONS
  AKI is a common complication in patients with malignant tumors, with post-renal obstruction as the most common factors. Hospital mortality in malignant tumor patients associated with AKI was higher, and the prevention of AKI is crucial in clinical.
authors.affiliation: Department of Nephrology, Xiangyang Central Hospital, Hubei University of Arts and Science Hubei, China.
authors.forename: Yongfang
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Department of Nephrology, Xiangyang Central Hospital, Hubei University of Arts and Science Hubei, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Xiangyang Central Hospital, Hubei University of Arts and Science Hubei, China.
authors.forename: Tingwei
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Nephrology, Xiangyang Central Hospital, Hubei University of Arts and Science Hubei, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Nephrology, Xiangyang Central Hospital, Hubei University of Arts and Science Hubei, China.
authors.forename: Fengqi
authors.initials: F
authors.lastname: Hu
keywords: Acute kidney injury; prognosis; risk factor; tumor