title: Au-Ag@Au Hollow Nanostructure with Enhanced Chemical Stability and Improved Photothermal Transduction Efficiency for Cancer Treatment.
abstract: Despite the fact that Au-Ag hollow nanoparticles (HNPs) have gained much attention as ablation agents for photothermal therapy, the instability of the Ag element limits their applications. Herein, excess Au atoms were deposited on the surface of a Au-Ag HNP by improving the reduction power of l-ascorbic acid (AA) and thereby preventing the reaction between HAuCl4 and the Ag element in the Au-Ag alloy nanostructure. Significantly, the obtained Au-Ag@Au HNPs show excellent chemical stability in an oxidative environment, together with remarkable increase in extinction peak intensity and obvious narrowing in peak width. Moreover, finite-difference time-domain (FDTD) was used to simulate the optical properties and electric field distribution of HNPs. The calculated results show that the proportion of absorption cross section in total extinction cross section increases with the improvement of Au content in HNP. As predicted by the theoretical calculation results, Au-Ag@Au nanocages (NCs) exhibit a photothermal transduction efficiency (η) as high as 36.5% at 808 nm, which is higher than that of Au-Ag NCs (31.2%). Irradiated by 808 nm laser at power densities of 1 W/cm(2), MCF-7 breast cancer cells incubated with PEGylated Au-Ag@Au NCs were seriously destroyed. Combined together, Au-Ag@Au HNPs with enhanced chemical stability and improved photothermal transduction efficiency show superior competitiveness as photothermal agents.
authors.affiliation: Key Laboratory of Strongly-Coupled Quantum Matter Physics, Chinese Academy of Sciences, School of Physical Sciences, University of Science and Technology of China , No. 96 Jinzhai Road, Hefei, Anhui Province 230026, China.
authors.forename: Tongtong
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Strongly-Coupled Quantum Matter Physics, Chinese Academy of Sciences, School of Physical Sciences, University of Science and Technology of China , No. 96 Jinzhai Road, Hefei, Anhui Province 230026, China.
authors.forename: Jiangluqi
authors.initials: J
authors.lastname: Song
authors.affiliation: Key Laboratory of Strongly-Coupled Quantum Matter Physics, Chinese Academy of Sciences, School of Physical Sciences, University of Science and Technology of China , No. 96 Jinzhai Road, Hefei, Anhui Province 230026, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Strongly-Coupled Quantum Matter Physics, Chinese Academy of Sciences, School of Physical Sciences, University of Science and Technology of China , No. 96 Jinzhai Road, Hefei, Anhui Province 230026, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Key Laboratory of Strongly-Coupled Quantum Matter Physics, Chinese Academy of Sciences, School of Physical Sciences, University of Science and Technology of China , No. 96 Jinzhai Road, Hefei, Anhui Province 230026, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: Center Laboratory, First Affiliated Hospital of Anhui Medical University , Hefei, Anhui Province 230026, China.
authors.forename: Ruixiang
authors.initials: R
authors.lastname: Xia
authors.affiliation: Center Laboratory, First Affiliated Hospital of Anhui Medical University , Hefei, Anhui Province 230026, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Strongly-Coupled Quantum Matter Physics, Chinese Academy of Sciences, School of Physical Sciences, University of Science and Technology of China , No. 96 Jinzhai Road, Hefei, Anhui Province 230026, China.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Xu
mesh_terms: D000497:Alloys; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001205:Ascorbic Acid; D002470:Cell Survival / Q000187:drug effects; D004355:Drug Stability; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D010789:Phototherapy; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000497:Alloys; D000970:Antineoplastic Agents; D012834:Silver; D006046:Gold; D001205:Ascorbic Acid
keywords: absorption; alloy; hollow nanostructure; photothermal therapy; stability