title: The use of growth factors, CD34(+) cells and fibrin for the management of chronic venous ulcers.
abstract: Chronic venous ulceration represents a very common event. Current standard treatment includes local wound care with the application of compression. We report the effects of platelet-rich plasma in patients with chronic venous ulcers, which is able to stimulate fibroblasts, macrophages and mesenchymal cells and growth factors in order to achieve re-epithelialisation and neovascularisation within the microenviroment of the wound. We also documented the efficacy of this method as the sole treatment without surgical procedures.
authors.affiliation: Department of General Medicine, ASP Catanzaro, Catanzaro, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Romano
authors.affiliation: Department of Health Science, University of Catanzaro, Catanzaro, Italy.|Clinical Pharmacology and Pharmacovigilance Operative Unit, Mater Domini University Hospital, Catanzaro, Italy.
authors.forename: Francesco M
authors.initials: FM
authors.lastname: Paolino
authors.affiliation: Department of Health Science, University of Catanzaro, Catanzaro, Italy.|Clinical Pharmacology and Pharmacovigilance Operative Unit, Mater Domini University Hospital, Catanzaro, Italy.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Rizzo
authors.affiliation: Unical, University of Calabria, Rende (CS), Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Russo
authors.affiliation: North Mississippi Sports Medicine & Orthopaedic Clinic, PLLC, Tupelo, MS, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Southworth
authors.affiliation: Interuniversity Center of Phlebolymphology (CIFL), University Magna Graecia of Catanzaro, Catanzaro, Italy.|Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Serra
authors.affiliation: Department of Health Science, University of Catanzaro, Catanzaro, Italy. gallelli@unicz.it.|Clinical Pharmacology and Pharmacovigilance Operative Unit, Mater Domini University Hospital, Catanzaro, Italy. gallelli@unicz.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Gallelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000627:therapeutic use*; D002908:Chronic Disease / Q000188:drug therapy*; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D018952:Antigens, CD34; D036341:Intercellular Signaling Peptides and Proteins; D005337:Fibrin
keywords: Chronic venous ulceration; Growth factors; Platelet-rich plasma