title: Preparation and Characterization of Low Molecular Weight Heparin by Liquid Phase Plasma Method.
abstract: An liquid phase plasma process system was applied to the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing liquid phase plasma treatment time. The abscission of the chemical bonds between the constituents of heparin by liquid phase plasma reaction did not alter the characteristics of heparin. Formation of any by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the liquid phase plasma reaction.
authors.forename: Do-Jin
authors.initials: DJ
authors.lastname: Lee
authors.forename: Hangun
authors.initials: H
authors.lastname: Kim
authors.forename: Byung Hoon
authors.initials: BH
authors.lastname: Kim
authors.forename: Young-Kwon
authors.initials: YK
authors.lastname: Park
authors.forename: Heon
authors.initials: H
authors.lastname: Lee
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Park
authors.forename: Sang-Chul
authors.initials: SC
authors.lastname: Jung
mesh_terms: D004339:Drug Compounding / Q000379:methods*; D006495:Heparin, Low-Molecular-Weight / Q000138:chemical synthesis* / Q000302:isolation & purification*; D008422:Materials Testing; D008970:Molecular Weight; D044367:Phase Transition; D058626:Plasma Gases / Q000737:chemistry*; D012996:Solutions
chemical_list: D006495:Heparin, Low-Molecular-Weight; D058626:Plasma Gases; D012996:Solutions