title: A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy.
abstract: In this report we present a polyketal, termed pADK, which has adamantane groups embedded in its backbone, and degrades into neutral excretable compounds. pADK was synthesized via click chemistry and had a MW of 49 472 and a PDI of 1.74. We demonstrate here that pADK can increase the transfection efficiency of CD1800 (PEI of 1800 modified β-cyclodextrin) 60 fold, yet cause no increase in toxicity.
authors.affiliation: University of California, Berkeley, USA. nmurthy@berkeley.edu.
authors.forename: Santanu
authors.initials: S
authors.lastname: Maity
authors.forename: Priya
authors.initials: P
authors.lastname: Choudhary
authors.forename: Manu
authors.initials: M
authors.lastname: Manjunath
authors.forename: Aditya
authors.initials: A
authors.lastname: Kulkarni
authors.forename: Niren
authors.initials: N
authors.lastname: Murthy
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000633:toxicity; D001711:Biotransformation; D004987:Ethers / Q000138:chemical synthesis* / Q000378:metabolism / Q000633:toxicity; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D049452:Green Fluorescent Proteins; D006367:HeLa Cells; D006801:Humans; D011094:Polyethyleneimine / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism / Q000633:toxicity; D012235:Rhodamines; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D004987:Ethers; D011108:Polymers; D012235:Rhodamines; D047392:beta-Cyclodextrins; D049452:Green Fluorescent Proteins; D011094:Polyethyleneimine; C029773:rhodamine B; D000218:Adamantane