title: Can we prevent type 1 diabetes?
abstract: Type 1 diabetes (T1D) affects 1.93 in 1000 youth in the USA. Over the last 40 years, a combination of genetic and immunological markers has been developed allowing for the accurate prediction of progression to T1D. Despite our abilities to predict disease and the marked improvement in our understanding of the natural history of T1D, therapies capable of preventing or reversing T1D remain elusive. This article will review recent and ongoing efforts to understand the causes of T1D and related efforts to study potential therapies aimed at preventing T1D.
authors.affiliation: University of Florida, PO Box 100296, Gainesville, FL, 32610, USA. gbeauchamp@ufl.edu.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Beauchamp
authors.affiliation: University of Florida, PO Box 100296, Gainesville, FL, 32610, USA. hallemj@peds.ufl.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Haller
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D004032:Diet; D018450:Disease Progression; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D000941:Antigens; D007328:Insulin
keywords: Antigen-specific therapy; Natural history; Non-antigen-specific therapy; Prevention; Type 1 diabetes