title: Micro- and nanodevices integrated with biomolecular probes.
abstract: Understanding how biomolecules, proteins and cells interact with their surroundings and other biological entities has become the fundamental design criterion for most biomedical micro- and nanodevices. Advances in biology, medicine, and nanofabrication technologies complement each other and allow us to engineer new tools based on biomolecules utilized as probes. Engineered micro/nanosystems and biomolecules in nature have remarkably robust compatibility in terms of function, size, and physical properties. This article presents the state of the art in micro- and nanoscale devices designed and fabricated with biomolecular probes as their vital constituents. General design and fabrication concepts are presented and three major platform technologies are highlighted: microcantilevers, micro/nanopillars, and microfluidics. Overview of each technology, typical fabrication details, and application areas are presented by emphasizing significant achievements, current challenges, and future opportunities.
authors.affiliation: Case Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Yunus
authors.initials: Y
authors.lastname: Alapan
authors.affiliation: Bio Micro/Nano Devices and Sensors Laboratory, Electrical and Electronics Engineering Department, Abdullah Gul University, Kayseri 38080, Turkey. Electronic address: kutay.icoz@agu.edu.tr.
authors.forename: Kutay
authors.initials: K
authors.lastname: Icoz
authors.affiliation: Case Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, OH 44106, USA; Biomedical Engineering Department, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Orthopaedics, Case Western Reserve University, Cleveland, OH 44106, USA; Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA. Electronic address: umut@case.edu.
authors.forename: Umut A
authors.initials: UA
authors.lastname: Gurkan
mesh_terms: D015374:Biosensing Techniques; D006801:Humans; D044085:Microfluidics; D015335:Molecular Probes / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics; D036103:Nanotechnology; D011506:Proteins / Q000737:chemistry* / Q000235:genetics
chemical_list: D015335:Molecular Probes; D011506:Proteins
keywords: Biomolecules; Biosensing; Cell adhesion; Cell isolation; Micro/nanofabrication; Micro/nanopillars; Microcantilevers; Microfluidic channels; Point-of-care diagnosis; Surface functionalization