title: Focal form of congenital hyperinsulinism clearly detectable by contrast-enhanced computed tomography imaging.
abstract: The focal form of congenital hyperinsulinism (CHI) is characterized by a cluster of abnormal insulin-oversecreting β cells within a restricted area of the pancreas. Although identification of the focal lesion is very important in the management of CHI, it has been reported that imaging studies, including computed tomography (CT), magnetic resonance imaging (MRI) scans, or angiography, are not helpful in identifying the focal lesion. Currently, fluorine-18-L-dihydroxyphenylalanine positron emission tomography ((18)F-DOPA PET) is believed to be the only imaging modality that can identify the focal lesions. In this report, however, we present a case of a 7-month-old girl with the focal form of CHI, caused by a loss-of-function mutation in the ABCC8 gene, whose lesion was clearly visible as a hyperenhancing nodule on contrast-enhanced CT and dynamic MRI imaging.
authors.affiliation: Department of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima, Osaka 534-0021 Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hashimoto
authors.affiliation: Department of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima, Osaka 534-0021 Japan.
authors.forename: Azumi
authors.initials: A
authors.lastname: Sakakibara
authors.affiliation: Department of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima, Osaka 534-0021 Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Kawakita
authors.affiliation: Department of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima, Osaka 534-0021 Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hosokawa
authors.affiliation: Department of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima, Osaka 534-0021 Japan.
authors.forename: Rika
authors.initials: R
authors.lastname: Fujimaru
authors.affiliation: Department of Pediatric Surgery, Osaka City General Hospital, Osaka, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Pathology, Osaka City General Hospital, Osaka, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Fukushima
authors.affiliation: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Igarashi
authors.affiliation: Department of Pediatrics, Kizawa Memorial Hospital, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan.
authors.forename: Michiya
authors.initials: M
authors.lastname: Masue
authors.affiliation: Department of Pediatrics, Kizawa Memorial Hospital, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Nishibori
authors.affiliation: Clinical Research Center, Osaka City General Hospital, Osaka, Japan.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Tamagawa
authors.affiliation: Clinical Research Center, Osaka City General Hospital, Osaka, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Murakami
authors.affiliation: Clinical Research Center, Osaka City General Hospital, Osaka, Japan.
authors.forename: Kazue
authors.initials: K
authors.lastname: Hatake
authors.affiliation: Department of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima, Osaka 534-0021 Japan ; Clinical Research Center, Osaka City General Hospital, Osaka, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Yorifuji