title: Lactic acidosis: Clinical implications and management strategies.
abstract: In hospitalized patients, elevated serum lactate levels are both a marker of risk and a target of therapy. The authors describe the mechanisms underlying lactate elevations, note the risks associated with lactic acidosis, and outline a strategy for its treatment.
authors.affiliation: Quality Officer, Medical Intensive Care Unit, Departments of Pulmonary Medicine and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. E-mail: reddya3@ccf.org.|Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Anita J
authors.initials: AJ
authors.lastname: Reddy
authors.affiliation: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.|Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Simon W
authors.initials: SW
authors.lastname: Lam
authors.affiliation: Medical ICU Clinical Specialist, Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Seth R
authors.initials: SR
authors.lastname: Bauer
authors.affiliation: Director, Medical Intensive Care Unit, Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Guzman
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D019468:Disease Management; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D012772:Shock, Septic / Q000150:complications*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
chemical_list: D002316:Cardiotonic Agents; D014662:Vasoconstrictor Agents