title: Aberrant de novo cholesterogenesis: Clinical significance and implications.
abstract: Human cells can acquire cholesterol from the circulation but also have the ability to synthesize it via de novo cholesterogenesis (DC). Cholesterol absorption and de novo cholesterogenesis are the key processes that modulate cholesterol homeostasis in the human body. The endogenous biosynthesis of cholesterol substantially contributes to the whole-body cholesterol pool. Additionally, dysregulation of this pathway is associated with diverse medical conditions. The present review focuses on our current understanding of the cholesterogenic pathway and the various different factors regulating this pathway. It also highlights dysregulation of this pathway in various physiological and pathological conditions including cardiovascular diseases, type II diabetes, obesity and viral infections.
authors.affiliation: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
authors.forename: Rida
authors.initials: R
authors.lastname: Rashid
authors.affiliation: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
authors.forename: Fatima
authors.initials: F
authors.lastname: Ameer
authors.affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany.
authors.forename: Hubert
authors.initials: H
authors.lastname: Kalbacher
authors.affiliation: Department of Radiation Oncology, 1300 Morris Park Avenue, 10461 Bronx, NY, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Scandiuzzi
authors.affiliation: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan. Electronic address: nzzaidi@yahoo.com.
authors.forename: Nousheen
authors.initials: N
authors.lastname: Zaidi
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis* / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D058990:Molecular Targeted Therapy
chemical_list: D002784:Cholesterol
keywords: Cholesterol absorption; De novo cholesterol synthesis; Mevalonate pathway