title: Inhaled treprostinil via the Tyvaso Inhalation System through a tracheostomy.
abstract: A 20-year-old man with pulmonary arterial hypertension secondary to systemic sclerosis was admitted to our hospital. Prior to admission, his PAH had been successfully managed with the use of tadalafil, ambrisentan and inhaled Tyvaso. Owing to respiratory failure from vocal cord paralysis, he underwent an emergent tracheotomy. The delivery of inhaled Tyvaso through a tracheostomy tube was explored. Post-tracheostomy, the patient continued his ability to self-administer the medication. His WHO functional classification, brain natriuretic peptide levels, and echocardiograms were not significantly different when Tyvaso was administered via tracheostomy compared with oral administration. This case report summarises the method used to deliver Tyvaso via a tracheostomy tube, which proved to be successful in this patient.
authors.affiliation: Pulmonary Hypertension Program, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
authors.forename: Jeryl
authors.initials: J
authors.lastname: Huckaby
authors.affiliation: Pulmonary Hypertension Program, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Lawrence
authors.affiliation: Pulmonary Hypertension Program, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Center
authors.affiliation: Pulmonary Hypertension Program, Children's Healthcare of Atlanta, Atlanta, Georgia, USA Children's Healthcare of Atlanta-Children's Physician Group, Department of Pulmonology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Dawn
authors.initials: D
authors.lastname: Simon
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D011464:Epoprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy*; D008297:Male; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000601:surgery; D014139:Tracheostomy; D014140:Tracheotomy; D014826:Vocal Cord Paralysis / Q000150:complications*; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D011464:Epoprostenol; C427248:treprostinil