title: Protein Phosphatases of Pathogenic Bacteria: Role in Physiology and Virulence.
abstract: The role of protein phosphatases in pathogenic bacteria has been studied extensively over the last two decades. Ser/Thr and Tyr phosphatases are associated with growth and virulence of many bacteria. These phosphatases control kinase-mediated functions and return the proteins to their unmodified state. Biochemical, structural, and functional studies, in addition to extensive genetic characterization, have highlighted the importance of phosphatases in bacteria. However, questions remain regarding the mechanisms driving localization of secretory phosphatases to cellular compartments, identification of receptor phosphatase sensory signals, and a possible role of cofactors and ligands in their functions. This review focuses on the role of Ser/Thr- and Tyr-specific phosphatases present in pathogenic bacteria, with an emphasis on the regulation of basic cellular processes and virulence. Furthermore, we highlight their clinical importance and analyze the development of drugs targeting protein phosphatases.
authors.affiliation: Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi 110007, India; email: ysingh@igib.res.in.
authors.forename: Andaleeb
authors.initials: A
authors.lastname: Sajid
authors.affiliation: Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi 110007, India; email: ysingh@igib.res.in.
authors.forename: Gunjan
authors.initials: G
authors.lastname: Arora
authors.affiliation: Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi 110007, India; email: ysingh@igib.res.in.
authors.forename: Anshika
authors.initials: A
authors.lastname: Singhal
authors.affiliation: Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi 110007, India; email: ysingh@igib.res.in.
authors.forename: Vipin C
authors.initials: VC
authors.lastname: Kalia
authors.affiliation: Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi 110007, India; email: ysingh@igib.res.in.
authors.forename: Yogendra
authors.initials: Y
authors.lastname: Singh
mesh_terms: D001419:Bacteria / Q000145:classification / Q000201:enzymology / Q000472:pathogenicity*; D018407:Bacterial Physiological Phenomena; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014774:Virulence
chemical_list: D010749:Phosphoprotein Phosphatases
keywords: Ser/Thr phosphatases; Tyr phosphatases; dephosphorylation; inhibitors; pathogens; regulation