title: Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis.
abstract: Traditional nuclear magnetic resonance (NMR) spectroscopy relies on the versatile chemical information conveyed by spectra. To complement conventional NMR, Laplace NMR explores diffusion and relaxation phenomena to reveal details on molecular motions. Under a broad concept of ultrafast multidimensional Laplace NMR, here we introduce an ultrafast diffusion-relaxation correlation experiment enhancing the resolution and information content of corresponding 1D experiments as well as reducing the experiment time by one to two orders of magnitude or more as compared with its conventional 2D counterpart. We demonstrate that the method allows one to distinguish identical molecules in different physical environments and provides chemical resolution missing in NMR spectra. Although the sensitivity of the new method is reduced due to spatial encoding, the single-scan approach enables one to use hyperpolarized substances to boost the sensitivity by several orders of magnitude, significantly enhancing the overall sensitivity of multidimensional Laplace NMR.
authors.affiliation: Faculty of Science, NMR Research Group, University of Oulu, PO Box 3000, 90014 Oulu, Finland.
authors.forename: Susanna
authors.initials: S
authors.lastname: Ahola
authors.affiliation: Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Instututskaya Street 3A, 630090 Novosibirsk, Russia.|Department of Natural Sciences, Novosibirsk State University, Pirogova Street 2, 630090 Novosibirsk, Russia.
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Zhivonitko
authors.affiliation: Faculty of Science, NMR Research Group, University of Oulu, PO Box 3000, 90014 Oulu, Finland.
authors.forename: Otto
authors.initials: O
authors.lastname: Mankinen
authors.affiliation: Department of Chemistry, Texas A&M University, 3255 TAMU, College Station, Texas 77843-3255, USA.
authors.forename: Guannan
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Faculty of Science, NMR Research Group, University of Oulu, PO Box 3000, 90014 Oulu, Finland.
authors.forename: Anu M
authors.initials: AM
authors.lastname: Kantola
authors.affiliation: Department of Chemistry, Texas A&M University, 3255 TAMU, College Station, Texas 77843-3255, USA.
authors.forename: Hsueh-Ying
authors.initials: HY
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Texas A&M University, 3255 TAMU, College Station, Texas 77843-3255, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Hilty
authors.affiliation: Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Instututskaya Street 3A, 630090 Novosibirsk, Russia.|Department of Natural Sciences, Novosibirsk State University, Pirogova Street 2, 630090 Novosibirsk, Russia.
authors.forename: Igor V
authors.initials: IV
authors.lastname: Koptyug
authors.affiliation: Faculty of Science, NMR Research Group, University of Oulu, PO Box 3000, 90014 Oulu, Finland.
authors.forename: Ville-Veikko
authors.initials: VV
authors.lastname: Telkki