title: Monitoring Diabetic Nephropathy by Circulating Gangliosides.
abstract: Gangliosides are multifunctional molecules, abundantly expressed in renal cell membrane but also in sera of patients with renal disease. The aim of this study was to quantify the serum levels of sialic acid-ganglioside in patients diagnosed with diabetes for an eventual biomarker stratification of patients with renal complications. We included 35 diabetic patients without metabolic complications, 35 patients with diabetic nephropathy, 35 non-diabetic individuals. We found that sialic acid ganglioside serum level was significantly increased in patients with diabetic nephropathy compared to the level obtained in patients with uncomplicated diabetes and to non-diabetic controls. A statistically significant positive correlation was obtained between serum levels of sialic acid gangliosides, HbA1c, and serum creatinine in patients with diabetes without complications. Moreover positive correlation was found between sialic acid ganglioside and blood glucose, HbA1c, urea, creatinine, microalbuminuria in patients with diabetic nephropathy. We can conclude that serum sialic acid-gangliosides are statistically increased in diabetic nephropathy positively correlated with microalbuminuria.
authors.affiliation: a Dr. Carol Davila Clinical Nephrology Hospital , Bucharest , Romania.
authors.forename: Corina Daniela
authors.initials: CD
authors.lastname: Ene
authors.affiliation: a Dr. Carol Davila Clinical Nephrology Hospital , Bucharest , Romania.
authors.forename: Mircea
authors.initials: M
authors.lastname: Penescu
authors.affiliation: b Skinmed Clinic , Bucharest , Romania.
authors.forename: Amalia
authors.initials: A
authors.lastname: Anghel
authors.affiliation: c Victor Babes National Institute of Pathology , Immunobiology Laboratory , Bucharest , Romania.
authors.forename: Monica
authors.initials: M
authors.lastname: Neagu
authors.affiliation: d Prof. Dr. D. Hociotă Institute of Phonoaudiology and Functional Surgery ENT , Bucharest , Romania.
authors.forename: Vlad
authors.initials: V
authors.lastname: Budu
authors.affiliation: e Dr. Victor Babes Clinical Hospital of Infections and Tropical Diseases , Research Department in Dermatology , Bucharest , Romania.
authors.forename: Ilinca
authors.initials: I
authors.lastname: Nicolae
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005732:Gangliosides / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D011446:Prospective Studies; D014508:Urea / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D003404:Creatinine; D005732:Gangliosides; D006442:Glycated Hemoglobin; D019158:N-Acetylneuraminic Acid; D014508:Urea; C517652:hemoglobin A1c protein, human
keywords: diabetes; diabetic nephropathy; glomerulonephritis; sialic acid ganglioside