title: Weight regaining: From statistics and behaviors to physiology and metabolism.
abstract: Achieving maintenance of weight loss is crucial to combat obesity. However, most individuals tend to regain weight. Data from successful maintainers show that they remain vigilant and constantly apply techniques to oppose the course of regaining. On the other hand, current advances in obesity research show that the reduced obese state is a state of altered physiology in terms of energy balance. This review describes the physiological adaptations occurring after weight loss that predispose to regaining. Specifically, changes regarding body composition, hormonal background, energy expenditure and control of food intake are discussed. Moreover, metabolites that can act as regain predictors and dietary techniques to oppose regaining are presented.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. Electronic address: acostas@hua.gr.
authors.forename: Costas A
authors.initials: CA
authors.lastname: Anastasiou
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Karfopoulou
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Mary
authors.initials: M
authors.lastname: Yannakoulia
mesh_terms: D001823:Body Composition; D004734:Energy Metabolism; D006801:Humans; D020738:Leptin / Q000502:physiology; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D020738:Leptin
keywords: Weight loss adaptations; Weight loss maintenance; Weight regain; Weight regain predictors