title: Association of human microRNAs miR-22 and miR-491 polymorphisms with panic disorder with or without agoraphobia in a Korean population.
abstract: BACKGROUND
  The possible involvement of microRNAs (miRNA) in psychiatric disorders has been recently recognized. Several miRNA polymorphisms have been found to be associated with panic disorder (PD) in European populations. However, the association of miRNA polymorphisms on PD has not been reported in Asian populations. We evaluated the effect of miR-22 and miR-491 polymorphisms on susceptibility to PD in a Korean population.
  
  
  METHODS
  Genotyping for four polymorphic variants of the primary miRNA (pri-miRNA) regions of miR-22 (rs8076112 and rs6502892) and miR-491 (rs4977831 and rs2039391) was performed using blood samples of 341 Korean patients with PD and 229 healthy control subjects. To evaluate PD phenotypes, the Panic Disorder Severity Scale (PDSS) and Anxiety Sensitivity Inventory-Revised (ASI-R) were administered.
  
  
  RESULTS
  Three single-nucleotide polymorphisms (SNPs) were found to be associated with PD: rs8076112 miR-22 and rs4977831 and miR-491 rs2039391. The rs8076112C/rs6502892C haplotypes of miR-22 and rs4977831G/rs2039391G and rs4977831A/rs2039391A haplotypes of miR-491 were significantly overrepresented in patients with PD than in healthy control subjects. In combination analysis, miR-22 rs8076112AC/rs6502892CC and rs8076112CC/rs6502892CC and miR-491 rs4977831AG/rs2039391AA were more frequent in patients with PD. Among the phenotype assessments, ASI-R scores were significantly associated with miR-22 rs6502892 in the subgroup with the agoraphobic phenotype.
  
  
  CONCLUSIONS
  The results should be considered preliminary due to the relatively small sample size and the selection of only four SNPs.
  
  
  CONCLUSIONS
  This is the first report to show possible associations of miR-22 and miR-491 with genetic susceptibility to PD in a Korean population.
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 463-712, Republic of Korea.
authors.forename: Borah
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 463-712, Republic of Korea.
authors.forename: Min Kyoung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 463-712, Republic of Korea.
authors.forename: Se-Woong
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 463-712, Republic of Korea.
authors.forename: Kyoung-Min
authors.initials: KM
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 463-400, Republic of Korea.
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 463-400, Republic of Korea.
authors.forename: Hui Jeong
authors.initials: HJ
authors.lastname: An
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 463-400, Republic of Korea.
authors.forename: Jung O
authors.initials: JO
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 463-712, Republic of Korea.
authors.forename: Tai Kiu
authors.initials: TK
authors.lastname: Choi
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 463-400, Republic of Korea. Electronic address: nkkim@cha.ac.kr.
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 463-712, Republic of Korea. Electronic address: leesanghyuk@yahoo.com.
authors.forename: Sang-Hyuk
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000235:genetics* / Q000523:psychology; D001008:Anxiety Disorders / Q000235:genetics; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D016584:Panic Disorder / Q000235:genetics* / Q000523:psychology; D010555:Personality Inventory; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: C548375:MIRN22 microRNA, human; D035683:MicroRNAs
keywords: Agoraphobia; Gene combination analysis; Haplotype analysis; Panic disorder; microRNAs