title: Monitoring the progression from intraductal carcinoma to invasive ductal carcinoma based on multiphoton microscopy.
abstract: Intraductal carcinoma is a precancerous lesion of the breast and the immediate precursor of invasive ductal carcinoma. Multiphoton microscopy (MPM) was used to monitor the progression from intraductal carcinoma to invasive ductal carcinoma, which can improve early detection of precursor lesions and halt progression to invasive neoplastic disease. It was found that MPM has the capability to reveal the qualitative changes in features of cells, structure of basement membranes, and architecture of collagens during the development from intraductal carcinoma to invasive ductal carcinoma, as well as the quantitative alterations in nuclear area, circle length of basement membrane, and collagen density. Combined with intra-fiberoptic ductoscopy or transdermal biopsy needle, MPM has the potential to provide immediate histological diagnosis of tumor progression in the field of breast carcinoma.
authors.affiliation: Fujian Normal University, Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, No. 8, Shangsan Road, Ca.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Affiliated Union Hospital of Fujian Medical University, Department of Breast Surgery, No. 29, Xinquan Road, Gulou, Fuzhou 350001, China.
authors.forename: Fangmeng
authors.initials: F
authors.lastname: Fu
authors.affiliation: Affiliated Union Hospital of Fujian Medical University, Department of Pathology, No. 29, Xinquan Road, Gulou, Fuzhou 350001, China.
authors.forename: Yuane
authors.initials: Y
authors.lastname: Lian
authors.affiliation: Fujian Normal University, Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, No. 8, Shangsan Road, Ca.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Nie
authors.affiliation: Fujian Normal University, Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, No. 8, Shangsan Road, Ca.
authors.forename: Shuangmu
authors.initials: S
authors.lastname: Zhuo
authors.affiliation: Affiliated Union Hospital of Fujian Medical University, Department of Breast Surgery, No. 29, Xinquan Road, Gulou, Fuzhou 350001, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Fujian Normal University, Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, No. 8, Shangsan Road, Ca.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods*; D008875:Middle Aged