title: Association and interaction analysis of excess weight and chronic kidney disease for cardiovascular autonomic neuropathy in the general Chinese population.
abstract: BACKGROUND
  The purpose of this study was to evaluate the associations of excess weight (EW) and/or chronic kidney disease (CKD) with cardiovascular autonomic neuropathy (CAN), and to detect the extent to which interaction of EW and CKD has on the outcome in a Chinese sample.
  
  
  METHODS
  We conducted a large-scale, population-based study to analyze the association and interaction of the two factors on CAN in a sample of 2092 Chinese people. Multiple linear regression analysis to include the two main factors and its interaction were employed to detect these relationships. Relative excess risk due to interaction (RERI), the proportion attributable to interaction (AP) and the synergy index (S) were used to estimate the effect of interaction on an additive scale can.
  
  
  RESULTS
  Multivariable logistic regression (MLR) indicated that body mass index (BMI) was independently associated with CAN (p = 0.006). In addition, a significant positive interaction between BMI and CKD on CAN was estimated (p = 0.042, RETI = 0.473, 95% CI: 0.0615-0.884, AP = 0.203, 95% CI: -0.055 to 0.461 and S = 1.550, 95% CI: 0.667-2.589).
  
  
  CONCLUSIONS
  Our findings suggest that BMI is independently associated with CAN and offer evidence to support the hypothesis that excess weight and CKD have significant positive interactions on CAN.
authors.affiliation: a Department of Nephrology , The Fifth Affiliated Hospital of Zhengzhou University , Zhengzhou , China and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Department of Nephrology , The Fifth Affiliated Hospital of Zhengzhou University , Zhengzhou , China and.
authors.forename: Nai-Jia
authors.initials: NJ
authors.lastname: Liu
authors.affiliation: a Department of Nephrology , The Fifth Affiliated Hospital of Zhengzhou University , Zhengzhou , China and.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Department of Nephrology , The Fifth Affiliated Hospital of Zhengzhou University , Zhengzhou , China and.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: b Department of Endocrinology and Metabolism , Shanghai Tongji Hospital, Tongji University School of Medicine , Shanghai , China.
authors.forename: Zi-Hui
authors.initials: ZH
authors.lastname: Tang
mesh_terms: D000368:Aged; D044466:Asian People; D001342:Autonomic Nervous System Diseases / Q000150:complications*; D015992:Body Mass Index; D002681:China / Q000208:ethnology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000208:ethnology*; D051436:Renal Insufficiency, Chronic / Q000208:ethnology*; D012307:Risk Factors
keywords: Association and interaction; Chinese; cardiovascular autonomic neuropathy; chronic kidney disease; excess weight