title: Association of the bradykinin receptors genes variants with hypertension: a case-control study and meta-analysis.
abstract: BACKGROUND
  The present study was to investigate the role of bradykinin receptors genes polymorphisms on hypertension risk in Northern Han Chinese population. We also carried out a meta-analysis on Chinese to derive a more full assessment of this association.
  
  
  RESULTS
  A total of 976 subjects from Northern Han Chinese and 7 studies with 1599 cases and 1425 controls were included in this case-control study and in the current meta-analysis, respectively. For the case-control study, we identified the genotypes of -58T/C and 1098A/G polymorphism in BDKRB2 and BDKRB1 genes, respectively, by TaqMan PCR method. Overall, we found significant association between the -58T/C polymorphism and the increased risk of hypertension in the allele comparison (p = 0.01, OR = 1.386, 95% CI [1.138-1.688]). Subgroup analysis by gender suggested that this obvious association could still be found in males, but not in females. For the 1098A/G polymorphism, no significant association was revealed in overall and subgroup analysis. For the meta-analysis involving the -58T/C polymorphism, a significant association between this polymorphism and hypertension was observed in the whole group. In Chinese Han subgroup, we found significant association with hypertension in allele comparison(C vs. T: p = 0.03, OR = 1.28, 95% CI 1.03-1.59, pheterogeneity = 0.05).
  
  
  CONCLUSIONS
  Our case-control study indicated that -58T/C might be significantly associated with the increased risk of hypertension in Northern Han Chinese population, which was partially confirmed by our meta-analysis.
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University , Beijing , People's Republic of China , and.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: b Department of Cardiology , Beijing Anzhen Hospital, Capital Medical University , Beijing , People's Republic of China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University , Beijing , People's Republic of China , and.
authors.forename: Zuoguang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University , Beijing , People's Republic of China , and.
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University , Beijing , People's Republic of China , and.
authors.forename: Jilin
authors.initials: J
authors.lastname: Liu
authors.affiliation: a Department of Hypertension Research , Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University , Beijing , People's Republic of China , and.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Wen
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D043783:Receptor, Bradykinin B1 / Q000235:genetics*; D043782:Receptor, Bradykinin B2 / Q000235:genetics*
chemical_list: D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2
keywords: Bradykinin receptors; Han Chinese; hypertension; meta-analysis, polymorphism