title: Epileptogenesis.
abstract: Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis. However, thanks to active research, a large number of animal models have become available for search of molecular mechanisms of epileptogenesis. The first glimpses of treatment targets and biomarkers that could be developed to become useful in clinic are in sight. However, the heterogeneity of the epilepsy condition, and the dynamics of molecular changes over the course of epileptogenesis remain as challenges to overcome.
authors.affiliation: Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland Department of Neurology, Kuopio University Hospital, FI-70211 Kuopio, Finland.
authors.forename: Asla
authors.initials: A
authors.lastname: Pitkänen
authors.affiliation: The Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Lukasiuk
authors.affiliation: Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah 84108.
authors.forename: F Edward
authors.initials: FE
authors.lastname: Dudek
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Staley
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D001930:Brain Injuries / Q000150:complications; D004195:Disease Models, Animal; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology*; D030141:Feedback, Psychological / Q000502:physiology; D023281:Genomics / Q000379:methods; D006801:Humans; D055432:Metabolomics / Q000379:methods; D020521:Stroke / Q000150:complications
chemical_list: D000927:Anticonvulsants; D015415:Biomarkers