title: The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolism.
abstract: Neonatal thromboembolic events are rare, and only a few cases of intrauterine spontaneous arterial thromboembolisms have been reported in the literature. Thrombolytic therapy with recombinant tissue plasminogen activator is usually the preferred treatment because it has a short half-life, fewer systemic side effects, and a strong, specific affinity for fibrin. Protocols vary from center to center, but there is still no consensus regarding the proper dosage or treatment duration. Herein, we present the case of an intrauterine spontaneous arterial thromboembolism in a preterm infant that completely resolved after being treated with low-dose recombinant tissue plasminogen activator (0.02 mg/kg/h).
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Demirelli
authors.affiliation: Atatürk University Faculty of Medicine, Division of Neonatology, Erzurum, Turkey Phone: +90 442 344 69 90 E-mail: k.tekgunduz@yahoo.com.tr.
authors.forename: Kadir Şerafettin
authors.initials: KŞ
authors.lastname: Tekgündüz
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Caner
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kara
mesh_terms: D001157:Arterial Occlusive Diseases / Q000151:congenital / Q000188:drug therapy*; D001916:Brachial Artery; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D017984:Enoxaparin / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D013923:Thromboembolism / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D017984:Enoxaparin; D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator