title: Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets.
abstract: The aim of current study was to explore the influence of three commonly used polymers, that is, cellulosics and noncellulosics, for example, Methocel K4M, Kollidon VA/64, and Soluplus, on the phase disproportionation and drug release profile of carbamazepine-succinic acid (CBZ-SUC) cocrystal at varying drug to polymer ratios (1 : 1 to 1 : 0.25) in matrix tablets. The polymorphic phase disproportionation during in-depth dissolution studies of CBZ-SUC cocrystals and its crystalline properties were scrutinized by X-ray powder diffractrometry and Raman spectroscopy. The percent drug release from HPMC formulations (CSH) showed inverse relation with the concentration of polymer; that is, drug release increased with decrease in polymer concentration. On contrary, direct relation was observed between percent drug release and polymer concentrations of Kollidon VA 64/Soluplus (CSK, CSS). At similar polymer concentration, drug release from pure carbamazepine was slightly lower with HPMC formulations than that of cocrystal; however, opposite trend in release rate was observed with Kollidon VA/64 and Soluplus. The significant increase in dissolution rate of cocrystal occurred with Kollidon VA/64 and Soluplus at higher polymer concentration. Moreover, no phase change took place in Methocel and Kollidon formulations. No tablet residue was left for Soluplus formulation so the impact of polymer on cocrystal integrity cannot be predicted.
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Majeed
authors.initials: M
authors.lastname: Ullah
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Hanif
authors.initials: H
authors.lastname: Ullah
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
authors.affiliation: Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Qaisar
authors.initials: Q
authors.lastname: Mahmood
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Izhar
authors.initials: I
authors.lastname: Hussain
mesh_terms: D002220:Carbamazepine / Q000737:chemistry / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D065546:Drug Liberation; D006801:Humans; D065347:Hypromellose Derivatives / Q000737:chemistry* / Q000494:pharmacology; D009536:Niacinamide / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D011145:Polyvinyls / Q000737:chemistry* / Q000494:pharmacology; D011205:Povidone / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D019802:Succinic Acid / Q000737:chemistry / Q000494:pharmacology; D013607:Tablets
chemical_list: D011108:Polymers; D011145:Polyvinyls; D013607:Tablets; C572167:polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; D009536:Niacinamide; D002220:Carbamazepine; D065347:Hypromellose Derivatives; D011092:Polyethylene Glycols; C584699:hypromellose 2906 (4000 mpa.s); D019802:Succinic Acid; D011205:Povidone