title: Biomagnification of endocrine disrupting chemicals (EDCs) by Pleuronectes yokohamae: Does P. yokohamae accumulate dietary EDCs?
abstract: We evaluated the potential for biomagnification of endocrine disrupting chemicals (EDCs) such as nonylphenol (NP), octylphenol (OP), bisphenol A (BP), and natural estrogens such as estrone (E1) and 17β-estradiol (E2) in a benthic fish, Pleuronectes yokohamae. The assimilation efficiencies (AE) of most EDCs ranged from 88 to 96% suggesting that they were efficiently incorporated and assimilated into P. yokohamae, except for NP (50%). However, the biomagnification factor (BMF) values were <1.0 suggesting that the compounds were not biomagnifying. Additionally, three of the target EDCs were not detected (BP, E1 and E2). Glucuronidation activity towards BP (11.44 ± 2.5 nmol/mg protein/min) and E2 (12.41 ± 3.2 nmol/mg protein/min) was high in the intestine suggesting that EDCs were glucuronidated prior to excretion into bile. Thus, we conclude that biomagnification of dietary EDCs is reduced in P. yokohamae because of effective glucuronidation.
authors.affiliation: United Graduate School of Agricultural Sciences, Kagoshima University, 4-50-20 Shimoarata, Kagoshima 890-0056, Japan; School of Marine and Environmental Sciences, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia.
authors.forename: Mohd Yusoff
authors.initials: MY
authors.lastname: Nurulnadia
authors.affiliation: Faculty of Fisheries, Kagoshima University, 4-50-20 Shimoarata, Kagoshima 890-0056, Japan. Electronic address: koyama@fish.kagoshima-u.ac.jp.
authors.forename: Jiro
authors.initials: J
authors.lastname: Koyama
authors.affiliation: Faculty of Fisheries, Kagoshima University, 4-50-20 Shimoarata, Kagoshima 890-0056, Japan.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Uno
authors.affiliation: School of Marine Biosciences, Kitasato University, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 252-0373, Japan.
authors.forename: Haruna
authors.initials: H
authors.lastname: Amano
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D052244:Endocrine Disruptors / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods*; D045166:Estradiol Congeners / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D004970:Estrone / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005432:Flounder / Q000378:metabolism*; D020719:Glucuronides / Q000378:metabolism; D010636:Phenols / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D045166:Estradiol Congeners; D004970:Estrone; D020719:Glucuronides; D010636:Phenols; D014874:Water Pollutants, Chemical; C474055:octylphenol; C025256:nonylphenol; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Assimilation efficiency; BMF; EDC; Glucuronidation