title: Hemodiafiltration efficacy in treatment of methanol and ethylene glycol poisoning in a 2-year-old girl.
abstract: BACKGROUND
  Every year about 2.4 million people in USA are exposed to toxic substances. Many of them are children below 6 years of age. Majority of poisonings in children are incidental and related to household products including for example drugs, cleaning products or antifreeze products. Antifreeze solutions contain ethylene glycol and methanol. Treatment of these toxic substances involves ethanol administration, fomepizole, hemodialysis and correction of metabolic acidosis.
  
  
  OBJECTIVE
  The aim of the study was to check the efficacy of continuous venovenous hemodiagiltration in intoxication with ethylene glycol and methanol.
  
  
  METHODS
  One year and 7 months old girl after intoxication with ethylene glycol and methanol was treated with continuous venovenous hemodiafiltration instead of hemodialysis because of technical problems (circulatory instability).
  
  
  RESULTS
  Intravenous ethanol infusion with hemodialtration resulted in rapid elimination of methanol from the body and significantly reduced blood ethylene glycol level.
  
  
  CONCLUSIONS
  Continuous venovenous hemodiafiltration can be helpful in treatment of ethylene glycol and methanol intoxication.
authors.affiliation: Department of Pediatric Nephrology, The Medical University of Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szmigielska
authors.affiliation: Department of Pediatric Nephrology, The Medical University of Warsaw, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Szymanik-Grzelak
authors.affiliation: Department of Pediatric Nephrology, The Medical University of Warsaw, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Kuźma-Mroczkowska
authors.affiliation: Department of Pediatric Nephrology, The Medical University of Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Roszkowska-Blaim
mesh_terms: D002675:Child, Preschool; D019855:Ethylene Glycol / Q000097:blood / Q000506:poisoning*; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D000432:Methanol / Q000506:poisoning*; D011041:Poisoning / Q000097:blood / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D019855:Ethylene Glycol; D000432:Methanol