title: MST kinases in development and disease.
abstract: The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called STK25 or SOK1). MST kinases are emerging as key signaling molecules that influence cell proliferation, organ size, cell migration, and cell polarity. Here we review the regulation and function of these kinases in normal physiology and pathologies, including cancer, endothelial malformations, and autoimmune disease.
authors.affiliation: The Francis Crick Institute, London WC2A 3LY, England, UK barry.thompson@crick.ac.uk erik.sahai@crick.ac.uk.
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Thompson
authors.affiliation: The Francis Crick Institute, London WC2A 3LY, England, UK barry.thompson@crick.ac.uk erik.sahai@crick.ac.uk.
authors.forename: Erik
authors.initials: E
authors.lastname: Sahai
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D002465:Cell Movement; D016764:Cell Polarity; D049109:Cell Proliferation; D047108:Embryonic Development; D004730:Endothelium, Vascular / Q000002:abnormalities / Q000201:enzymology*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D009929:Organ Size; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity
chemical_list: D005656:Fungal Proteins; D017346:Protein Serine-Threonine Kinases