title: Hippocampal Infusion of Zeta Inhibitory Peptide Impairs Recent, but Not Remote, Recognition Memory in Rats.
abstract: Spatial memory in rodents can be erased following the infusion of zeta inhibitory peptide (ZIP) into the dorsal hippocampus via indwelling guide cannulas. It is believed that ZIP impairs spatial memory by reversing established late-phase long-term potentiation (LTP). However, it is unclear whether other forms of hippocampus-dependent memory, such as recognition memory, are also supported by hippocampal LTP. In the current study, we tested recognition memory in rats following hippocampal ZIP infusion. In order to combat the limited targeting of infusions via cannula, we implemented a stereotaxic approach for infusing ZIP throughout the dorsal, intermediate, and ventral hippocampus. Rats infused with ZIP 3-7 days after training on the novel object recognition task exhibited impaired object recognition memory compared to control rats (those infused with aCSF). In contrast, rats infused with ZIP 1 month after training performed similar to control rats. The ability to form new memories after ZIP infusions remained intact. We suggest that enhanced recognition memory for recent events is supported by hippocampal LTP, which can be reversed by hippocampal ZIP infusion.
authors.affiliation: Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Jena B
authors.initials: JB
authors.lastname: Hales
authors.affiliation: Department of Psychology, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Amber C
authors.initials: AC
authors.lastname: Ocampo
authors.affiliation: Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Broadbent
authors.affiliation: Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA ; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Clark
mesh_terms: D000818:Animals; D057846:Cell-Penetrating Peptides; D006624:Hippocampus / Q000187:drug effects*; D007858:Learning / Q000187:drug effects; D055666:Lipopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D057567:Memory, Long-Term / Q000187:drug effects*; D008570:Memory, Short-Term / Q000187:drug effects*; D008845:Microinjections; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D020318:Rats, Long-Evans; D021641:Recognition, Psychology / Q000187:drug effects*; D013028:Space Perception / Q000187:drug effects; D013238:Stereotaxic Techniques
chemical_list: D057846:Cell-Penetrating Peptides; D055666:Lipopeptides; C568285:zeta-inhibitory peptide