title: Utility of Contrast-enhanced Ultrasonography with Perflubutane for Determining Histologic Grade in Hepatocellular Carcinoma.
abstract: The purpose of this study was to clarify the diagnostic value of contrast-enhanced ultrasonography (CEUS) with perflubutane in determining the histologic grade in hepatocellular carcinoma (HCC). A total of 147 surgically resected HCCs were dichotomized as well differentiated HCC (wd-HCC) and moderately- or poorly-differentiated HCC (mp-HCC). CEUS findings were evaluated during the arterial phase (vascularity, level and shape of enhancement), portal phase (presence or absence of washout) and post-vascular phase (echo intensity and shape). Receiver operating characteristic (ROC) curve analysis for the diagnosis of mp-HCC yielded area under the ROC curve (Az) values for arterial phase vascularity and portal phase washout of 0.910 and 0.807, respectively. The Az value for the combination of vascularity and washout for the diagnosis of mp-HCC was 0.956 (95% confidence interval, 0.910-0.979), corresponding to high diagnostic value. In conclusion, CEUS can provide high-quality imaging assessment for determining the histologic grade of HCCs.
authors.affiliation: Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan. Electronic address: tadat0627@gmail.com.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Tada
authors.affiliation: Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kumada
authors.affiliation: Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Toyoda
authors.affiliation: Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Radiology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sone
authors.affiliation: Department of Surgery, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kaneoka
authors.affiliation: Department of Surgery, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Maeda
authors.affiliation: Department of Pathologic Diagnosis, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Okuda
authors.affiliation: Department of Imaging Diagnosis, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Otobe
authors.affiliation: Department of Imaging Diagnosis, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D005466:Fluorocarbons; D006801:Humans; D007089:Image Enhancement; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D060787:Neoplasm Grading; D012372:ROC Curve; D015203:Reproducibility of Results; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; C108042:perfluorobutane
keywords: Contrast-enhanced ultrasonography; Hepatocellular carcinoma; Histologic grade