title: Hepatotoxicity Secondary to Chemotherapy.
abstract: The difficult problem faced by multiple generation of practicing physicians is determining the cause of abnormal liver function tests in cancer patients on chemotherapy. Hepatotoxicity from chemotherapy occurs frequently from an unpredictable or idiosyncratic reaction. Despite remarkable advances in our understanding of the mechanisms of action, pharmacodynamics, and interrelationships between the liver and chemotherapy, the underlying etiology of hepatic toxicity for various agents remains unexplained. Here, we present a concise review of the broad differential diagnosis for abnormal liver function tests (LFTs) in oncology patients.
authors.affiliation: Divisions of Liver and GI Transplantation, University of Miami School of Medicine, Miami, FL, USA.
authors.forename: Alla
authors.initials: A
authors.lastname: Grigorian
authors.affiliation: Divisions of Liver and GI Transplantation, University of Miami School of Medicine, Miami, FL, USA.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: O'Brien
keywords: Cancer; Chemotherapy; Drugs; Hepatotoxicity; Liver