title: Clinical and Prognostic Value of Depressive Symptoms and N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Eisenmenger Syndrome.
abstract: OBJECTIVE
  Eisenmenger syndrome (ES) is commonly associated with depressive symptoms and elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP). We investigated the predictive value of depressive symptoms and NTproBNP levels for long-term outcomes in patients with ES.
  
  
  METHODS
  Blood was drawn to measure NT-proBNP, and depressive symptoms were measured using the Korean version of the Beck Depression Inventory (BDI) in an outpatient clinic sample of 64 patients with ES (67% female; median age = 41.5 years [range, 21.0-74.8 years]). Cardiac events (hospitalization, emergency department visits, and cardiac death) were monitored during 3 years of follow-up.
  
  
  RESULTS
  During the follow-up period, 15 (23.4%) patients experienced a cardiac event. The combination of depressive symptoms and NT-proBNP levels better predicted future cardiac events than either variable alone. Patients with NT-proBNP > 510 pg/ml and a total BDI score > 10 had a 9.6 times higher risk for cardiac events than did patients with NT-proBNP ≤ 510 pg/ml or total BDI score ≤ 10 (p < .001).
  
  
  CONCLUSIONS
  Depressive symptoms and NT-proBNP levels are both associated with adverse clinical outcomes in ES.
authors.affiliation: From the Grown-Up Congenital Heart Clinic (Moon), Heart Vascular & Stroke Institute, Samsung Medical Center, Seoul, Republic of Korea; Department of Medical Humanities & Social Medicine (D.R. Kang), Office of Biostatistics, Ajou University School of Medicine, Suwon, Republic of Korea; Departments of Pediatrics (Song, Huh, I.-S. Kang) and Medicine, Division of Cardiology, (Chang, Park), Heart Vascular & Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Boram Hospital Ulsan & Insuk Medical Center (Lee), Ulsan, Republic of Korea.
authors.forename: Ju Ryoung
authors.initials: JR
authors.lastname: Moon
authors.forename: Dae Ryong
authors.initials: DR
authors.lastname: Kang
authors.forename: Jinyoung
authors.initials: J
authors.lastname: Song
authors.forename: June
authors.initials: J
authors.lastname: Huh
authors.forename: I-Seok
authors.initials: IS
authors.lastname: Kang
authors.forename: Sung A
authors.initials: SA
authors.lastname: Chang
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Heung Jae
authors.initials: HJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000097:blood* / Q000503:physiopathology*; D004541:Eisenmenger Complex / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain