title: Extraction, identification and antimicrobial activity of a new furanone, grifolaone A, from Grifola frondosa.
abstract: A furanone (1), (S)-methyl 2-(2-hydroxy-3,4-dimethyl-5-oxo-2,5-dihydrofuran-2-yl)acetate, was isolated from the edible mushroom Grifola frondosa. Mass spectrometry and NMR analyses were used to elucidate the structure of this compound, and its absolute configuration was determined using circular dichroism spectroscopy. Compound 1 exhibited specific antifungal activity against the plant pathogens, Fusarium oxysporum, Gibberella zeae and Piricularia oryzae and the opportunistic human pathogen, Pseudallescheria boydii, resulting in minimum inhibitory concentration values of 2.5, 2.5, 1.25 and 0.15 μg/mL, respectively. In contrast, the furanone showed only weak activity towards Aspergillus spp., Candida albicans and several other fungal strains tested as well as no appreciable antibacterial activity.
authors.affiliation: a College of Life Science , Hubei University , Wuhan , China.|b Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests , Fuzhou , China.|c Key Laboratory of Biopesticide and Chemical Biology , Ministry of Education , Fuzhou , China.|d National Engineering Research Center of Juncao Technology , Fuzhou , China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: He
authors.affiliation: a College of Life Science , Hubei University , Wuhan , China.
authors.forename: Xuezhu
authors.initials: X
authors.lastname: Du
authors.affiliation: b Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests , Fuzhou , China.|c Key Laboratory of Biopesticide and Chemical Biology , Ministry of Education , Fuzhou , China.
authors.forename: Xiangyun
authors.initials: X
authors.lastname: Zang
authors.affiliation: b Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests , Fuzhou , China.|c Key Laboratory of Biopesticide and Chemical Biology , Ministry of Education , Fuzhou , China.
authors.forename: Lili
authors.initials: L
authors.lastname: Dong
authors.affiliation: b Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests , Fuzhou , China.|c Key Laboratory of Biopesticide and Chemical Biology , Ministry of Education , Fuzhou , China.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Gu
authors.affiliation: b Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests , Fuzhou , China.|c Key Laboratory of Biopesticide and Chemical Biology , Ministry of Education , Fuzhou , China.
authors.forename: Liping
authors.initials: L
authors.lastname: Cao
authors.affiliation: e College of Bee Science , Fujian Agriculture and Forestry University , Fuzhou , China.
authors.forename: Dafu
authors.initials: D
authors.lastname: Chen
authors.affiliation: f Department of Microbiology and Cell Science , Institute of Food and Agricultural Sciences, University of Florida , Gainesville , FL , USA.
authors.forename: Nemat O
authors.initials: NO
authors.lastname: Keyhani
authors.affiliation: b Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests , Fuzhou , China.|c Key Laboratory of Biopesticide and Chemical Biology , Ministry of Education , Fuzhou , China.
authors.forename: Lindan
authors.initials: L
authors.lastname: Yao
authors.affiliation: b Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests , Fuzhou , China.|c Key Laboratory of Biopesticide and Chemical Biology , Ministry of Education , Fuzhou , China.|d National Engineering Research Center of Juncao Technology , Fuzhou , China.
authors.forename: Junzhi
authors.initials: J
authors.lastname: Qiu
authors.affiliation: b Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests , Fuzhou , China.|c Key Laboratory of Biopesticide and Chemical Biology , Ministry of Education , Fuzhou , China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Guan
mesh_terms: D000363:Agaricales / Q000737:chemistry; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects; D048691:Grifola / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000935:Antifungal Agents; D005663:Furans; C000612020:grifolaone A
keywords: Grifola frondosa; antifungal activity; furanone