title: Removal Characteristics of Immunoglobulin G Subclasses by Conventional Plasma Exchange and Selective Plasma Exchange.
abstract: Selective plasma exchange (SePE) using a selective membrane separator is a modified method of simple plasma exchange (PE). Immunoglobulin G (IgG) subclass distribution is one of the important immunological characteristics of IgG. However, there is little information regarding the removal characteristics of IgG subclasses by SePE and conventional PE. Here, we investigated the removal ratio of IgG subclasses by PE and SePE in seven patients with immunological disorders. When the mean processed volume was 0.88 plasma volume (PV) (corresponding to 2.12 L), the mean percent reductions by PE were as follows: IgG, 63.2%; IgG1, 64.5%; IgG2, 64.0%; IgG3, 61.4%; and IgG4, 69.5%. When the mean processed volume was 1.18 PV (corresponding to 2.98 L), the mean percent reductions by SePE were as follows: IgG, 51.6%; IgG1, 55.3%; IgG2, 52.0%; IgG3, 53.7%; and IgG4, 64.6%. In both PE and SePE, using albumin solution as the supplementary fluid, IgG was effectively eliminated regardless of IgG subclasses.
authors.affiliation: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohkubo
authors.affiliation: Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Okado
authors.affiliation: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kurashima
authors.affiliation: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Arai
authors.affiliation: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Miyamoto
authors.affiliation: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Itagaki
authors.affiliation: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Seshima
authors.affiliation: Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Iimori
authors.affiliation: Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Naito
authors.affiliation: Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Eisei
authors.initials: E
authors.lastname: Sohara
authors.affiliation: Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Uchida
authors.affiliation: Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Tatemitsu
authors.initials: T
authors.lastname: Rai
mesh_terms: D000328:Adult; D000368:Aged; D057186:Comparative Effectiveness Research; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000097:blood / Q000628:therapy; D007074:Immunoglobulin G / Q000097:blood*; D007564:Japan; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010951:Plasma Exchange / Q000295:instrumentation / Q000379:methods; D010956:Plasmapheresis / Q000295:instrumentation / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G; D008567:Membranes, Artificial
keywords: Immunoglobulin G subclasses; Membrane plasma separator; Processed plasma volume; Removal ratio; Selective plasma exchange