title: Further New Xenicanes from a Chinese Collection of the Brown Alga Dictyota plectens.
abstract: Four new xenicanes, namely 4α-hydroxyisodictyohemiacetal (1), 4α-hydroxyisodictyoacetal (2), 13,18-diacetoxy-4-hydroxyisodictyo-19-al (3), and 4α-hydroxypachylactone (8), were isolated from a Chinese collection of the brown alga Dictyota plectens, along with four known analogues (4-7). The structures of the new diterpenes were determined by extensive spectroscopic data analysis. All compounds were evaluated for their antiviral activities against human immunodeficiency virus type 1 (HIV-1) and the highly pathogenic avian influenza A (H5N1) virus, and inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages (PEMΦ).
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Shimiao
authors.initials: S
authors.lastname: Cheng
authors.forename: Weiping
authors.initials: W
authors.lastname: Yuan
authors.forename: Jianyong
authors.initials: J
authors.lastname: Dong
authors.forename: Kexin
authors.initials: K
authors.lastname: Huang
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Sun
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Yan
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D057809:HEK293 Cells; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D000459:Phaeophyceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; D008070:Lipopolysaccharides; D009569:Nitric Oxide