title: Modelling the Impact of Atherosclerosis on Drug Release and Distribution from Coronary Stents.
abstract: Although drug-eluting stents (DES) are now widely used for the treatment of coronary heart disease, there remains considerable scope for the development of enhanced designs which address some of the limitations of existing devices. The drug release profile is a key element governing the overall performance of DES. The use of in vitro, in vivo, ex vivo, in silico and mathematical models has enhanced understanding of the factors which govern drug uptake and distribution from DES. Such work has identified the physical phenomena determining the transport of drug from the stent and through tissue, and has highlighted the importance of stent coatings and drug physical properties to this process. However, there is limited information regarding the precise role that the atherosclerotic lesion has in determining the uptake and distribution of drug. In this review, we start by discussing the various models that have been used in this research area, highlighting the different types of information they can provide. We then go on to describe more recent methods that incorporate the impact of atherosclerotic lesions.
authors.affiliation: Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK.
authors.forename: C M
authors.initials: CM
authors.lastname: McKittrick
authors.affiliation: Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
authors.forename: S
authors.initials: S
authors.lastname: Kennedy
authors.affiliation: West of Scotland Region Heart and Lung Centre, Golden Jubilee National Hospital, Dunbartonshire, UK.
authors.forename: K G
authors.initials: KG
authors.lastname: Oldroyd
authors.affiliation: Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK.
authors.forename: S
authors.initials: S
authors.lastname: McGinty
authors.affiliation: Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK. christopher.mccormick@strath.ac.uk.
authors.forename: C
authors.initials: C
authors.lastname: McCormick
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D003331:Coronary Vessels / Q000378:metabolism / Q000503:physiopathology; D054855:Drug-Eluting Stents; D006801:Humans; D008955:Models, Cardiovascular; D010599:Pharmacokinetics
keywords: Arteries; Atherosclerosis; Computational models; Drug distribution; Drug transport; Drug uptake; Drug-eluting stents; In vitro models; In vivo models; Mathematical models