title: The Memory Function of the B Cell Antigen Receptor.
abstract: Activated B lymphocytes preserve their antigen experience by differentiating into long-lived pools of antibody-secreting plasma cells or various types of memory B cells (MBCs). The former population constantly produces serum immunoglobulins with sufficient specificity and affinity to thwart infections with recurrent pathogens. By contrast, memory B cell populations retain their antigen receptors on the cell surface and hence need pathogen-induced differentiation steps before they can actively contribute to host defense. The terminal differentiation of MBCs into antibody-secreting plasma cells is hallmarked by the absence of the lag phase characteristic for primary antibody responses. Moreover, secondary antibody responses are predominantly driven by MBCs that bear an antigen receptor of the IgG class on their surface although IgM-positive memory populations exist as well. These fundamental principles of B cell memory were enigmatic for decades. Only recently, we have begun to understand the underlying mechanisms. This review summarizes our current understanding of how different subpopulations of MBCs are generated during primary immune responses and how their functional heterogeneity on antigen recall is controlled by different signaling capabilities of B cell antigen receptor (BCR) isotypes and by the nature of the antigen.
authors.affiliation: Medical Faculty, Institute of Cellular and Molecular Immunology, Georg-August-University of Göttingen, Humboldtallee 34, 37073, Göttingen, Germany. jwienan@gwdg.de.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Wienands
authors.affiliation: Medical Faculty, Institute of Cellular and Molecular Immunology, Georg-August-University of Göttingen, Humboldtallee 34, 37073, Göttingen, Germany. nengels@gwdg.de.
authors.forename: Niklas
authors.initials: N
authors.lastname: Engels
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000276:immunology*
chemical_list: D011947:Receptors, Antigen, B-Cell