title: Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy.
abstract: We used generalized estimating equations to quantify the impact of recent vaccination or intercurrent infections on immune and inflammatory biomarkers among 144 human immunodeficiency virus (HIV)-infected adults with HIV RNA < 50 copies/mL on antiretroviral therapy. These events were associated with a 2.244 µg/mL increase in high sensitivity C-reactive protein and should be routinely assessed in future studies.
authors.affiliation: Departments of Medicine ; Division of Infectious Diseases , St. Michael's Hospital ; Division of Infectious Diseases ; Toronto General Research Institute , University Health Network , Ontario, Canada.
authors.forename: Darrell H S
authors.initials: DH
authors.lastname: Tan
authors.affiliation: Toronto General Research Institute , University Health Network , Ontario, Canada.
authors.forename: Leah
authors.initials: L
authors.lastname: Szadkowski
authors.affiliation: Dalla Lana School of Public Health , University of Toronto ; Toronto General Research Institute , University Health Network , Ontario, Canada.
authors.forename: Janet
authors.initials: J
authors.lastname: Raboud
authors.affiliation: Immunology.
authors.forename: Tae Joon
authors.initials: TJ
authors.lastname: Yi
authors.affiliation: Immunology.
authors.forename: Brett
authors.initials: B
authors.lastname: Shannon
authors.affiliation: Departments of Medicine ; Immunology ; Division of Infectious Diseases ; Toronto General Research Institute , University Health Network , Ontario, Canada.
authors.forename: Rupert
authors.initials: R
authors.lastname: Kaul
authors.affiliation: Department of Medicine , University of Washington , Seattle.
authors.forename: W Conrad
authors.initials: WC
authors.lastname: Liles
authors.affiliation: Departments of Medicine ; Division of Infectious Diseases ; Toronto General Research Institute , University Health Network , Ontario, Canada.
authors.forename: Sharon
authors.initials: S
authors.lastname: Walmsley
keywords: C-reactive protein; HIV; immune activation; infections; inflammatory biomarkers; vaccinations