title: Neuroimaging for patient selection for medial temporal lobe epilepsy surgery: Part 1 Structural neuroimaging.
abstract: The objective of part one of this review is to present the structural neuroimaging techniques that are currently used to evaluate patients with temporal lobe epilepsy (TLE), and to discuss their potential to define patient eligibility for medial temporal lobe surgery. A PubMed query, using Medline and Embase, and subsequent review, was performed for all English language studies published after 1990, reporting neuroimaging methods for the evaluation of patients with TLE. The extracted data included demographic variables, population and study design, imaging methods, gold standard methods, imaging findings, surgical outcomes and conclusions. Overall, 56 papers were reviewed, including a total of 1517 patients. This review highlights the following structural neuroimaging techniques: MRI, diffusion-weighted imaging, tractography, electroencephalography and magnetoencephalography. The developments in neuroimaging during the last decades have led to remarkable improvements in surgical precision, postsurgical outcome, prognosis, and the rate of seizure control in patients with TLE. The use of multiple imaging methods provides improved outcomes, and further improvements will be possible with future studies of larger patient cohorts.
authors.affiliation: Department of Neurosurgery, The Chaim Sheba Medical Center, Nissim Aloni 16, Tel Aviv-Yafo 62919, Israel. Electronic address: spetros@live.com.
authors.forename: Petros
authors.initials: P
authors.lastname: Stylianou
authors.affiliation: Department of Radiology, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Chen
authors.initials: C
authors.lastname: Hoffmann
authors.affiliation: Department of Neurology, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Ilan
authors.initials: I
authors.lastname: Blat
authors.affiliation: Department of Neurosurgery, The Chaim Sheba Medical Center, Nissim Aloni 16, Tel Aviv-Yafo 62919, Israel.
authors.forename: Sagi
authors.initials: S
authors.lastname: Harnof
mesh_terms: D000293:Adolescent; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D018579:Patient Selection; D011379:Prognosis; D013702:Temporal Lobe / Q000601:surgery
keywords: Neuroimaging; Patient selection; Structural neuroimaging; Surgical candidates; Temporal lobe epilepsy; Temporal lobe surgery