title: Pulmonary and ventricular functions in children with repaired tetralogy of Fallot.
abstract: OBJECTIVE
  This study aimed to evaluate biventricular function, brain natriuretic peptide levels, respiratory function test and 6 minute walking test (6MWT) in children with repaired tetralogy of Fallot (TOF), and analyse the correlation between these variables and clinical status.
  
  
  METHODS
  Twenty-five children (14 boys, 11 girls; aged 6 to 17 years) with repaired TOF (Group 1) and 25 age-sex matched healthy controls (Group 2) were enrolled in the study. Tissue Doppler echocardiography, respiratory function test, 6MWT distance and brain natriuretic peptide levels were measured.
  
  
  RESULTS
  Mean ages of the children at TOF corrective surgery and at study time were 5.1±3.5 years and 11.6±2.7 years respectively. The duration between palliative operation and corrective surgery was 4.3±2.0 years, and the follow-up period after corrective surgery was 6.3±3.0 years. The right ventricular and left ventricular myocardial performance indices (MPIs), and isovolumic relaxation and contraction times were significantly higher in Group 1 than in Group 2 (p<0.01). Spirometry displayed significantly reduced forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory flow 25-75% (FEF25-75) and inspirational capacity in Group 1 compared to Group 2 (p<0.01). In Group 1, 6MWT distances were significantly lower than in Group 2 (p=0.001). Right ventricular MPI is correlated with FEV1, FVC and 6MWT distance in the current study.
  
  
  CONCLUSIONS
  The children with repaired TOF had impaired ventricular and pulmonary functions. Hence, right ventricular MPI along with FEV1, FVC and 6MWT distance may be useful in the follow-up of children with repaired TOF.
authors.affiliation: Department of Pediatric Cardiology, Sifa University Faculty of Medicine, Izmir, Turkey. savasdemirpence@yahoo.com.
authors.forename: Savaş
authors.initials: S
authors.lastname: Demirpençe
authors.affiliation: Department of Pediatric Cardiology, Izmir University Faculty of Medicine, Medical Park Hospital, Izmir, Turkey.
authors.forename: Barış
authors.initials: B
authors.lastname: Güven
authors.affiliation: Department of Pediatric Cardiology, Behçet Uz Children Hospital, Izmir, Turkey.
authors.forename: Murat Muhtar
authors.initials: MM
authors.lastname: Yılmazer
authors.affiliation: Department of Pediatric Cardiology, Behçet Uz Children Hospital, Izmir, Turkey.
authors.forename: Taliha
authors.initials: T
authors.lastname: Öner
authors.affiliation: Department of Pediatric Cardiology, Behçet Uz Children Hospital, Izmir, Turkey.
authors.forename: Önder
authors.initials: Ö
authors.lastname: Doksöz
authors.affiliation: Department of Pediatric Cardiology, Behçet Uz Children Hospital, Izmir, Turkey.
authors.forename: Rahmi
authors.initials: R
authors.lastname: Özdemir
authors.affiliation: Department of Pediatric Allergy and Immunology, Behçet Uz Children Hospital, Izmir, Turkey.
authors.forename: Hikmet Tekin
authors.initials: HT
authors.lastname: Nacaroğlu
authors.affiliation: Department of Pediatric Cardiology, Behçet Uz Children Hospital, Izmir, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Meşe
authors.affiliation: Department of Pediatric Cardiology, Sifa University Faculty of Medicine, Izmir, Turkey.
authors.forename: Vedide
authors.initials: V
authors.lastname: Tavlı
authors.affiliation: Department of Pediatric Allergy and Immunology, Behçet Uz Children Hospital, Izmir, Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Can
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011665:Pulmonary Valve Insufficiency / Q000503:physiopathology*; D013147:Spirometry; D013771:Tetralogy of Fallot / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D020097:Natriuretic Peptide, Brain