title: Design, synthesis, and biological evaluation of 2-substituted ethenesulfonic acid ester derivatives as selective PTP1B inhibitors.
abstract: Fifteen 2-substituted ethenesulfonic acid ester derivatives were designed, synthesized, and evaluated for the inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and T-Cell protein tyrosine phosphatase (TCPTP). The structural activity relationship (SAR) of these compounds are discussed to clarify the impact of the linker and the optimized tail on the inhibitory activity of PTP1B and selectivity over TCPTP. Most of the compounds exhibit excellent inhibitory activities against PTP1B with IC50 values of 1.5-8.9 μM. SAR analysis reveal that the substituents at the hydrophobic tail significantly alter the inhibitory activity against PTP1 B and selectivity over TCPTP, e.g. compound 5d showed excellent inhibitory activity to PTP1B with IC50 = 7.8 μM, and -6-fold selectivity over TCPTP. Combined with our previous findings, we confirm that the linker length and the substituted hydrophobic tail have decisive influence on the PTP1B inhibitory activity and selectivity.
authors.forename: Jingbao
authors.initials: J
authors.lastname: Liu
authors.forename: Xinxian
authors.initials: X
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Buzhe
authors.initials: B
authors.lastname: Xu
authors.forename: Wenlu
authors.initials: W
authors.lastname: Liu
authors.forename: Faqin
authors.initials: F
authors.lastname: Jiang
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D008958:Models, Molecular; D011485:Protein Binding; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013451:Sulfonic Acids; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1