title: From necessity to sufficiency in memory research: when sleep helps to understand wake experiences.
abstract: Memory is the ability to adapt our behavior by using the stored information, previously encoded. The first investigations of the neuronal bases of the memory trace concerned its properties (location, cellular and molecular mechanisms, among others). However, to understand how this is achieved at the scale of neurons, we must provide evidence about the necessity of a neuronal subpopulation to support the memory trace, but also its sufficiency. Here, we will present past and recent studies that provide information about the neuronal nature of memories. We will show that research on sleep, when cells assembly supposedly carrying information from the past are replayed, could also provide valuable information about the memory processes at stake during wake.
authors.affiliation: Team Memory, Oscillations and Brain states (MOBs), Brain Plasticity Unit, CNRS UMR 8249, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris - ParisTech, Paris, France.
authors.forename: Marie Masako
authors.initials: MM
authors.lastname: Lacroix
authors.affiliation: Team Memory, Oscillations and Brain states (MOBs), Brain Plasticity Unit, CNRS UMR 8249, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris - ParisTech, Paris, France.
authors.forename: Gaetan
authors.initials: G
authors.lastname: De Lavilléon
authors.affiliation: Team Memory, Oscillations and Brain states (MOBs), Brain Plasticity Unit, CNRS UMR 8249, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris - ParisTech, Paris, France. Electronic address: karim.benchenane@espci.fr.
authors.forename: Karim
authors.initials: K
authors.lastname: Benchenane
mesh_terms: D000818:Animals; D006801:Humans; D008568:Memory / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D062308:Optogenetics / Q000379:methods*; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*