title: Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria.
abstract: Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines. Bronner et al. (2015) show that during Brucella abortus infection, an endoplasmic reticulum stress sensor, IRE1α, initiates NLRP3- and caspase-2-mediated mitochondrial damage that potentiates NLRP3 inflammasome assembly.
authors.affiliation: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Sunny
authors.initials: S
authors.lastname: Shin
authors.affiliation: Department of Pathology and Laboratory Medicine, the Children's Hospital of Philadelphia and the Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: yargon@med.upenn.edu.
authors.forename: Yair
authors.initials: Y
authors.lastname: Argon
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D053143:Caspase 2 / Q000276:immunology*; D059865:Endoplasmic Reticulum Stress / Q000276:immunology*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D008928:Mitochondria / Q000276:immunology*
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D053143:Caspase 2