title: Evidence for Infection and Inflammation in Infant Deaths in a Country with Historically Low Incidences of Sudden Infant Death Syndrome.
abstract: Total infant mortality in Hungary has been higher than other European countries; however, the reported incidence of sudden infant death syndrome (SIDS) has been lower. The low incidence of SIDS in Hungary has been supported by evidence obtained from the high rate of scene of death investigation and medico-legal autopsy mandatory since the 1950s. In this study, we compared the incidence of explained and unexplained infant deaths in Hungary for three periods: 1979-1989 when the incidence of SIDS was high in western Europe; 1990-1999 when the incidence of infant deaths was falling following introduction of the public health campaigns to reduce the risk factors associated with SIDS; and 2000-2012 to determine if introduction of Haemophilus influenzae type b or pneumococcal vaccines or introduction of an earlier immunization schedule during this period had an effect on SIDS. Explained infant deaths fell consistently during this period; however, SIDS rose during the second period when the incidence of SIDS was falling in other European countries. Evidence for infection and/or inflammation was observed for the majority of SIDS during each period. The results are discussed in relation to campaigns to reduce infant mortality in Hungary and the introduction of new vaccines and an earlier immunization schedule in 2006.
authors.affiliation: Department of Forensic and Insurance Medicine, Semmelweis University , Budapest , Hungary.
authors.forename: Klára
authors.initials: K
authors.lastname: Törő
authors.affiliation: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University , Budapest , Hungary.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Vörös
authors.affiliation: St. László Hospital for Infectious Diseases, National Institute of Child Health , Budapest , Hungary.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Mészner
authors.affiliation: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University , Budapest , Hungary.
authors.forename: Aletta
authors.initials: A
authors.lastname: Váradi-T
authors.affiliation: Department of Pathology, Military Hospital - National Health Center , Budapest , Hungary.
authors.forename: Adrienn
authors.initials: A
authors.lastname: Tóth
authors.affiliation: Hungarian Demographic Research Institute , Budapest , Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Kovács
keywords: immunization; infant mortality; infection; inflammation; sudden infant death syndrome