title: Iloprost administration in acrodermatitis of Hallopeau complicated by acquired toes syndactyly: a case report and review of the literature.
abstract: OBJECTIVE
  Acrodermatitis Continua of Hallopeau (ACH) is a variant of pustular psoriasis often very difficult to treat. Secondary syndactyly, also called "pseudosyndactyly", is rare and can be a complication of burns, dystrophic epidermolysis bullosa or trauma. If left untreated, joint complications and definitive functional impairments may occur.
  
  
  METHODS
  We report a case of a 74-year-old man with acrodermatitis continua of Hallopeau involving the toes and complicated by syndactyly. ACH regression following Iloprost administration was also observed.
  
  
  CONCLUSIONS
  Published studies are mainly limited to case reports only, due to the rarity of the disease. Therefore, there are no clear-cut therapeutic management guidelines available for this chronic and sometimes debilitating disease. ACH is often recalcitrant to the available therapies. Topical and systemic treatments have been described in literature with no long-lasting results.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of foot syndactyly associated to ACH. In our patient, ACH symptoms regressed with Iloprost administration: this finding has never been previously described in literature. If confirmed by other clinical experiences, Iloprost could be a further therapeutic option in ACH.
authors.affiliation: Plastic and Reconstructive Surgery Unit, Università Campus Bio-Medico di Roma, Rome, Italy. g.marangi@unicampus.it.
authors.forename: F
authors.initials: F
authors.lastname: Segreto
authors.forename: D
authors.initials: D
authors.lastname: Tosi
authors.forename: G F
authors.initials: GF
authors.lastname: Marangi
authors.forename: A L
authors.initials: AL
authors.lastname: Pendolino
authors.forename: S
authors.initials: S
authors.lastname: Santoro
authors.forename: P
authors.initials: P
authors.lastname: Gigliofiorito
authors.forename: P
authors.initials: P
authors.lastname: Persichetti
mesh_terms: D000169:Acrodermatitis / Q000188:drug therapy*; D000368:Aged; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011565:Psoriasis / Q000150:complications*; D013576:Syndactyly / Q000188:drug therapy*; D014034:Toes / Q000002:abnormalities*
chemical_list: D016285:Iloprost