title: PBA regulates neurogenesis and cognition dysfunction after repeated electroconvulsive shock in a rat model.
abstract: Electroconvulsive therapy (ECT) was widely used to treat the refractory depression. But ECT led to the cognitive deficits plaguing the depression patients. The underlying mechanisms of the cognitive deficits remain elusive. Repeated electroconvulsive shock (rECS) was used to simulate ECT and explore the mechanisms of ECT during the animal studies. Previous studies showed rECS could lead to neurogenesis and cognitive impairment. But it was well known that neurogenesis could improve the cognition. So these suggested that the mechanism of the cognitive deficit after rECS was very complex. In present study, we explored the probable mechanisms of the cognitive deficit after rECS from neurogenesis aspect. We found the cognitive deficit was reversible and neurogenesis could bring a long-term beneficial effect on cognition. Astrogliosis and NR1 down-regulation probably participated in the reversible cognitive deficits after rECS. Phenylbutyric acid (PBA), generally as an agent to investigate the roles of histone acetylation, could prevent the reversible cognitive dysfunction, but PBA could diminish the long-term effect of enhanced cognition by rECS. These suggested that ECT could possibly bring the long-term beneficial cognitive effect by regulating neurogenesis.
authors.affiliation: Department of Geriatrics, Renmin Hospital of Wuhan University, #238 Jiefang Road, Wuhan 430060, China; Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: yaozhaohui2004@126.com.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Yao
authors.affiliation: Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Kang
authors.affiliation: Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Geriatrics, Renmin Hospital of Wuhan University, #238 Jiefang Road, Wuhan 430060, China.
authors.forename: Li
authors.initials: L
authors.lastname: Nie
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000818:Animals; D001253:Astrocytes / Q000187:drug effects; D015153:Blotting, Western; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism; D003866:Depressive Disorder / Q000628:therapy; D004565:Electroconvulsive Therapy; D004597:Electroshock / Q000009:adverse effects*; D038362:Glycogen Synthase Kinase 3 / Q000187:drug effects / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D042421:Histone Code / Q000187:drug effects; D007150:Immunohistochemistry; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D057567:Memory, Long-Term / Q000187:drug effects; D055495:Neurogenesis / Q000187:drug effects* / Q000502:physiology; D010654:Phenylbutyrates / Q000494:pharmacology*; D051057:Proto-Oncogene Proteins c-akt / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D060449:Wnt Signaling Pathway / Q000187:drug effects
chemical_list: D010654:Phenylbutyrates; D000071679:Glycogen Synthase Kinase 3 beta; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3
keywords: Cognitive deficit; Neurogenesis; Phenylbutyric acid (PBA); Repeated electroconvulsive shock