title: Clinical and prognostic significance of pathological and inflammatory markers in the surgical treatment of locally advanced colorectal cancer.
abstract: BACKGROUND
  Locally advanced colorectal cancer (CRC) may vary in its clinical and pathological appearance. It is now accepted that progression of disease in patients with locally advanced CRC is determined not only by local tumor characteristics but also by the immune system and inflammatory response in the body.
  
  
  METHODS
  We investigated patients with confirmed CRC who were treated in the surgical clinic at the University Hospital Alexandrovska over a 10-year period and retrospectively evaluated the histological features of the preoperative biopsies and operative specimens removed during radical multivisceral resections. We also collected prospective data for serum C-reactive protein levels and Jass-Klintrup score, Petersen Index score, and Glasgow Prognostic Score in patients with locally advanced CRC.
  
  
  RESULTS
  Of 1,105 patients with CRC, 327 (29.6%) were diagnosed with locally advanced disease. In total, 108 combined multivisceral resections (79 for primary tumors and 29 for recurrent tumors) were performed. Overall survival was 34 months for pR0 cases and 12 months for pR1 cases (P<0.05). Our data confirmed that C-reactive protein is a prognostic marker of overall survival. Data for 48 patients with histologically confirmed locally advanced tumors showed significantly increased survival with a higher Jass-Klintrup score (P=0.037). In patients with node-negative disease, 5-year survival was 49%. However, where there were high-risk pathological characteristics according to the Petersen Index, survival was similar to that for node-positive disease (P=0.702). Our data also showed a significant difference in survival between groups divided according to whether they had a modified Glasgow Prognostic Score of 1 or 2 (P=0.031).
  
  
  CONCLUSIONS
  In order to maintain a reasonable balance between an aggressive approach and so-called meaningless "surgical exorbitance", we should focus on certain histopathological and inflammatory markers that can be identified as additional factors for planning the type and volume of surgical treatment.
authors.affiliation: Department of Surgery, Medical University of Sofia, Sofia, Bulgaria.
authors.forename: M
authors.initials: M
authors.lastname: Sokolov
authors.affiliation: Department of Surgery, Medical University of Sofia, Sofia, Bulgaria.
authors.forename: K
authors.initials: K
authors.lastname: Angelov
authors.affiliation: Department of Surgery, Medical University of Sofia, Sofia, Bulgaria.
authors.forename: M
authors.initials: M
authors.lastname: Vasileva
authors.affiliation: Department of Anesthesiology and Intensive Care, Medical University of Sofia, Sofia, Bulgaria.
authors.forename: M P
authors.initials: MP
authors.lastname: Atanasova
authors.affiliation: Department of Pathology, University Hospital Alexandrovska, Medical University of Sofia, Sofia, Bulgaria.
authors.forename: A
authors.initials: A
authors.lastname: Vlahova
authors.affiliation: Department of Surgery, Medical University of Sofia, Sofia, Bulgaria.
authors.forename: G
authors.initials: G
authors.lastname: Todorov
keywords: C-reactive protein; Glasgow Prognostic Score; Jass-Klintrup score; Petersen Index; locally advanced colorectal cancer