title: Effects of sugammadex on the prevention of postoperative peritoneal adhesions.
abstract: Many materials and techniques have been used to prevent and repair intra-abdominal adhesions, but an effective solution has not been found. The aim of this study is to research the effect of sugammadex on intra-abdominal adhesions in an experimentally induced intra-abdominal adhesion model. Twenty-four female Wistar albino rats were included in the study. The experimental animals were randomly divided into three groups: the sugammadex group (Group SX, n = 8), the control group (Group C, n = 8), and the sham group (Group S, n = 8). After starvation for 1 night, the rats were injected with a 50 mg/kg intramuscular dose of ketamine and a 5 mg/kg intramuscular dose of xylazine for anesthesia. The rats in the SX group were given 3 mL sugammadex into the peritoneal cavity, while rats in the control group were given 3 mL 0.9% sodium chloride. In the sham group, the peritoneal cavity was opened, but no chemicals were administered. All rats were sacrificed on the 10(th) postoperative day. The adhesions were staged as 0, 1, 2, and 3 according to Evans et al.'s model. Our evaluation of macroscopic adhesion intensity found statistically significant differences between the groups. The sugammadex group was observed to have fewer adhesions in a statistically significant manner compared with the control group (p < 0.05). In our experimental intra-abdominal adhesion model in rats, we observed that sugammadex prevented postoperative intra-abdominal adhesions.
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. Electronic address: drsahin17@gmail.com.
authors.forename: Hasan
authors.initials: H
authors.lastname: Şahin
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Toman
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Kiraz
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Tuncer
authors.initials: T
authors.lastname: Şimşek
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Erbaş
authors.affiliation: Department of General Surgery, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Özkul
authors.affiliation: Department of General Surgery, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Muhammet Kasım
authors.initials: MK
authors.lastname: Arık
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Hancı
mesh_terms: D000818:Animals; D005260:Female; D010532:Peritoneal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D017208:Rats, Wistar; D000077122:Sugammadex; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D047408:gamma-Cyclodextrins / Q000627:therapeutic use*
chemical_list: D047408:gamma-Cyclodextrins; D000077122:Sugammadex
keywords: Experimental study; Peritoneal adhesion; Rats; Sugammadex; Surgery