title: Officinalioside, a new lignan glucoside from Borago officinalis L.
abstract: A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC50: 52.6 ± 1.70 and 41.3 ± 0.25 μM, respectively) comparable with that of the standard trolox (16.6 ± 2.2 μM) without any significant cytotoxicity towards human cell line A549 (IC50 > 100 μM).
authors.affiliation: a Department of Pharmacognosy, Graduate School of Biomedical & Health Sciences , Hiroshima University , Hiroshima , Japan.|b Faculty of Pharmacy, Department of Pharmacognosy , Minia University , Minia , Egypt.
authors.forename: Mamdouh Nabil
authors.initials: MN
authors.lastname: Samy
authors.affiliation: b Faculty of Pharmacy, Department of Pharmacognosy , Minia University , Minia , Egypt.
authors.forename: Ashraf Nageeb El-Sayed
authors.initials: AN
authors.lastname: Hamed
authors.affiliation: a Department of Pharmacognosy, Graduate School of Biomedical & Health Sciences , Hiroshima University , Hiroshima , Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugimoto
authors.affiliation: c Faculty of Pharmacy, Department of Natural Product Chemistry , Yasuda Women's University , Hiroshima , Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
authors.affiliation: b Faculty of Pharmacy, Department of Pharmacognosy , Minia University , Minia , Egypt.
authors.forename: Mohamed Salah
authors.initials: MS
authors.lastname: Kamel
authors.affiliation: a Department of Pharmacognosy, Graduate School of Biomedical & Health Sciences , Hiroshima University , Hiroshima , Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsunami
mesh_terms: D029683:Borago / Q000737:chemistry*; D045744:Cell Line, Tumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D045792:Norisoprenoids / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D016166:Free Radical Scavengers; D005960:Glucosides; D044949:Kaempferols; D017705:Lignans; D045792:Norisoprenoids; D010936:Plant Extracts; C553885:crotalionoside C; C000612023:officinalioside; C438027:roseoside
keywords: Boraginaceae; Borago officinalis; DPPH; cytotoxicity; lignan; officinalioside