title: Targeting Batf2 for infectious diseases and cancer.
abstract: The family members Batf, Batf2 and Batf3 belong to a class of transcription factors containing basic leucine zipper domains that regulate various immunological functions and control the development and differentiation of immune cells. Functional studies by others demonstrated a predominant role for Batf in controlling Th2 cell functions and lineage development of T lymphocytes as well as a critical role of Batf, Batf2 and Batf3 in CD8α+dendritic cell development. Moreover, Batf family member expression was measured in a vast collection of mouse and human cell types by cap analysis gene expression (CAGE), a recent developed sequencing technology, showing reasonable expression spectrum in immune cells consistent with previously published expression profiles. Batf and Batf3 were highly expressed in lymphocytes and the earlier moderately expressed in myeloid lineages. Batf2 was predominantly expressed in monocytes/macrophages. Functional studies in mice demonstrated that Batf2 has a central role in macrophage activation by regulating inflammatory responses during lipopolysaccharides stimulation and mycobacterial infection. Hence, Batf2 could be used as a biomarker and a potential host directed drug target in tuberculosis. Moreover, Batf2 act as a tumor suppressor gene and augmenting Batf2 in malignant cells might be an encouraging therapeutic treatment against cancer.
authors.affiliation: International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa.|Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, Health Science Faculty, University of Cape Town, Cape Town, South Africa.
authors.forename: Reto
authors.initials: R
authors.lastname: Guler
authors.affiliation: RIKEN Center for Life Science Technologies, Division of Genomic Technologies, Tsurumi-ku, Yokohama, Japan.
authors.forename: Sugata
authors.initials: S
authors.lastname: Roy
authors.affiliation: RIKEN Center for Life Science Technologies, Division of Genomic Technologies, Tsurumi-ku, Yokohama, Japan.
authors.forename: Harukazu
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa.|Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, Health Science Faculty, University of Cape Town, Cape Town, South Africa.
authors.forename: Frank
authors.initials: F
authors.lastname: Brombacher
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D003141:Communicable Diseases / Q000378:metabolism*; D003713:Dendritic Cells / Q000166:cytology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007107:Immune System; D007249:Inflammation; D008070:Lipopolysaccharides / Q000378:metabolism; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D009164:Mycobacterium Infections / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D059467:Transcriptome; D014376:Tuberculosis / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C576672:BATF2 protein, mouse; D050976:Basic-Leucine Zipper Transcription Factors; C569485:Batf2 protein, human; D015415:Biomarkers; D008070:Lipopolysaccharides; D025521:Tumor Suppressor Proteins
keywords: cancer; host-directed drug therapy; transcription factors; transcriptomics; tuberculosis