title: Irreversible Electroporation in the Treatment of Hepatocellular Carcinoma.
abstract: Irreversible electroporation (IRE) is a new nonthermal ablation modality that can be used to treat primary and metastatic lesions in the liver. This article describes the way IRE works, reviews safety and efficacy data, and presents strategies and recommendations for its use in everyday practice. In a series of liver lesions of various histologies, initial success was 100%; local recurrence rates were greater in larger lesions. In another series of hepatocellular carcinoma only, there was a 79% complete response rate overall and 93% in lesions less than 3 cm. Safety is comparable with those of other ablation modalities. IRE has advantages over other ablation modalities with comparable success rates.
authors.affiliation: Division of Vascular Interventional Radiology, University of Miami Miller School of Medicine, Miami, FL; Division of Diagnostic Imaging and Intervention, Pisa University School of Medicine, Pisa, Italy. Electronic address: riccardo.lencioni@med.unipi.it.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Lencioni
authors.affiliation: Division of Diagnostic Imaging and Intervention, Pisa University School of Medicine, Pisa, Italy; Division of Diagnostic Imaging and Intervention, Pisa University School of Medicine, Pisa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Crocetti
authors.affiliation: Division of Vascular Interventional Radiology, University of Miami Miller School of Medicine, Miami, FL.
authors.forename: Govindarajan
authors.initials: G
authors.lastname: Narayanan
mesh_terms: D055011:Ablation Techniques / Q000009:adverse effects; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D016923:Cell Death; D018274:Electroporation / Q000379:methods*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications / Q000209:etiology; D012307:Risk Factors; D025321:Surgery, Computer-Assisted / Q000009:adverse effects / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: hepatocellular carcinoma; image-guided ablation; irreversible electroporation