title: The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity?
abstract: Current evidence indicates that the consumption of strawberries, a natural source of a wide range of nutritive and bioactive compounds, is associated with the prevention and improvement of chronic-degenerative diseases. Studies involving cells and animals provide evidence on the anti-inflammatory, anticarcinogenic and antiproliferative activity of the strawberry. Epidemiological and clinical studies demonstrate that its acute consumption increases plasma antioxidant capacity, improves circulating inflammatory markers and ameliorates postprandial glycemic response. At the same time, a protracted intake reduces chronic inflammation and improves plasma lipid profile, supporting cardiovascular health, especially in individuals with increased risk for metabolic syndrome. To explain these beneficial effects, much attention has been paid in the past to the antioxidant properties of strawberry polyphenols. However, recent research has shown that their biological and functional activities are related not only to the antioxidant capacity but also to the modulation of many cellular pathways involved in metabolism, survival, proliferation, and antioxidant defenses. The aim of this review is to update and discuss the molecular and cellular mechanisms proposed in recent studies to elucidate the healthy effects of strawberry polyphenols against the most common chronic diseases, such as cancer, cardiovascular diseases, metabolic syndrome, and inflammation.
authors.affiliation: a Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica , Facoltà di Medicina, Università Politecnica delle Marche , Ancona , Italy.|b Area de Nutrición y Salud, Universidad Internacional Iberoamericana (UNINI) , Campeche Mexico.
authors.forename: Tamara Y
authors.initials: TY
authors.lastname: Forbes-Hernandez
authors.affiliation: a Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica , Facoltà di Medicina, Università Politecnica delle Marche , Ancona , Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Gasparrini
authors.affiliation: a Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica , Facoltà di Medicina, Università Politecnica delle Marche , Ancona , Italy.
authors.forename: Sadia
authors.initials: S
authors.lastname: Afrin
authors.affiliation: c Dipartimento Scienze Biomediche e Sanità Pubblica , Facoltà di Medicina, Università Politecnica delle Marche , Ancona , Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bompadre
authors.affiliation: d Dipartimento di Scienze Agrarie , Alimentari e Ambientali, Università Politecnica delle Marche , Ancona , Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Mezzetti
authors.affiliation: e Department of Physiology , Institute of Nutrition and Food Technology ''José Mataix", Biomedical Research Centre, University of Granada , Granada , Spain.
authors.forename: Josè L
authors.initials: JL
authors.lastname: Quiles
authors.affiliation: a Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica , Facoltà di Medicina, Università Politecnica delle Marche , Ancona , Italy.|f Centre for Nutrition & Health, Universidad Europea del Atlantico (UEA) , Santander , Spain.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giampieri
authors.affiliation: a Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica , Facoltà di Medicina, Università Politecnica delle Marche , Ancona , Italy.|f Centre for Nutrition & Health, Universidad Europea del Atlantico (UEA) , Santander , Spain.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002317:Cardiovascular Agents / Q000494:pharmacology; D031985:Fragaria / Q000737:chemistry*; D006801:Humans; D023421:Models, Animal; D059808:Polyphenols / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D015415:Biomarkers; D002317:Cardiovascular Agents; D059808:Polyphenols
keywords: Strawberry; cancer; cardiovascular diseases; inflammation; metabolism; polyphenols