title: Botulinum toxin and the treatment of headache: A clinical review.
abstract: Since its discovery, Onabotulinum toxins have been tried for the treatment of various head, neck and face pain syndromes. The end result of controlled clinical trials was that there was not clear evidence for use in many of the common primary and secondary headaches. In chronic migraine, affecting 1-2% of the population, a fixed site and fixed dose treatment approach was shown to be superior to placebo and was approved for use. In this review, evidence for that use and the history leading to it is described.
authors.affiliation: The Carolina Headache Institute, University of North Carolina, Chapel Hill, USA. Electronic address: finkela@chi09.com.
authors.forename: Alan G
authors.initials: AG
authors.lastname: Finkel
mesh_terms: D001905:Botulinum Toxins / Q000627:therapeutic use*; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D006261:Headache / Q000188:drug therapy*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy; D018781:Tension-Type Headache / Q000188:drug therapy
chemical_list: D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A
keywords: Chronic migraine; Headache; Migraine; Onabotulinum toxin A; Tension type headache; Treatment