title: Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations.
abstract: Bellini and colleagues demonstrate the importance of next-generation sequencing to uncover subclonal anaplastic lymphoma kinase (ALK) mutations in neuroblastoma. Although the significance of these subclonal aberrations is not yet understood, deep sequencing could identify patients whose tumors may respond to ALK inhibitors.
authors.affiliation: Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. rani_george@dfci.harvard.edu.
authors.forename: Rani E
authors.initials: RE
authors.lastname: George
mesh_terms: D060965:Clonal Evolution / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D009447:Neuroblastoma / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D020794:Receptor Protein-Tyrosine Kinases