title: [Idiopathic Nephrotic Syndrome: recommendations of the Nephrology Branch of the Chilean Society of Pediatrics. Part One].
abstract: Idiopathic nephrotic syndrome is the most common glomerular disease in childhood, affecting 1 to 3 per 100,000 children under the age of 16. It most commonly occurs in ages between 2 and 10. Its cause is unknown and its histology corresponds to minimal change disease in 90% of cases, or focal segmental glomerulosclerosis. 80 to 90% of cases respond to steroids (steroid-sensitive nephrotic syndrome) with good prognosis and long-term preservation of renal function over time. 70% of patients with SSNS have one or more relapses in their evolution, and of these, 50% behave as frequent relapsing or steroid-dependent, a group that concentrate the risk of steroid toxicity. Patients with steroid-resistant nephrotic syndrome have a poor prognosis and 50% of them evolve to end-stage renal disease. The goal of therapy is to induce and maintain remission of the disease, reducing the risk secondary to proteinuria while minimizing the adverse effects of treatments, especially with prolonged use of corticosteroids. This paper is the result of the collaborative effort of the Nephrology Branch of the Chilean Society of Pediatrics with aims at helping pediatricians and pediatric nephrologists to treat pediatric SNI. In this first part, recommendations of steroid-sensitive nephrotic syndrome are discussed.
authors.affiliation: Unidad de Nefrología, Hospital San Juan de Dios, Santiago, Chile. Electronic address: pilarheviaj@gmail.com.
authors.forename: Pilar
authors.initials: P
authors.lastname: Hevia
authors.affiliation: Unidad de Nefrología, Hospital Metropolitano La Florida, Santiago, Chile.
authors.forename: Vilma
authors.initials: V
authors.lastname: Nazal
authors.affiliation: Unidad de Nefrología, Hospital San Juan de Dios, Santiago, Chile.
authors.forename: María Pía
authors.initials: MP
authors.lastname: Rosati
authors.affiliation: Unidad de Nefrología, Hospital de Carabineros, Santiago, Chile.
authors.forename: Lily
authors.initials: L
authors.lastname: Quiroz
authors.affiliation: Unidad de Nefrología, Hospital Felix Bulnes, Santiago, Chile.
authors.forename: Claudia
authors.initials: C
authors.lastname: Alarcón
authors.affiliation: Unidad de Nefrología, Complejo Asistencial Dr. Sótero del Río, Santiago, Chile.
authors.forename: Sonia
authors.initials: S
authors.lastname: Márquez
authors.affiliation: Unidad de Nefrología, Hospital San Juan de Dios, Santiago, Chile.
authors.forename: Karen
authors.initials: K
authors.lastname: Cuevas
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002677:Chile; D018450:Disease Progression; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000517:prevention & control; D009402:Nephrosis, Lipoid / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology
chemical_list: D005938:Glucocorticoids
keywords: Children; Corticosensible; Glomerulopathy; Glomerulopatía; Nephrotic syndrome; Niños; Steroid-sensitive; Síndrome nefrótico; Tratamiento; Treatment