title: Neuroprotective agents for neonatal hypoxic-ischemic brain injury.
abstract: Hypoxic-ischemic (H-I) brain injury in newborns is a major cause of morbidity and mortality that claims thousands of lives each year. In this review, we summarize the promising neuroprotective agents tested on animal models and pilot clinical studies of neonatal H-I brain injury according to the different phases of the disease. These agents target various phases of injury including the early phase of excitotoxicity, oxidative stress and apoptosis as well as late-phase inflammatory reaction and neural repair. We analyze the cell survival and cell death pathways modified by these agents in neonatal H-I brain injury. We aim to 'build a bridge' between animal trials of neuroprotective agents and potential candidate treatments for future clinical applications against H-I encephalopathy.
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Acupuncture and Moxibustion College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610091, China.
authors.forename: Qiaofeng
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Clinical Laboratory, Dongfeng Hospital of Hubei University of Medicine, Shiyan, Hubei 442012, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Boston University School of Medicine, Boston, MA 02118, USA.
authors.forename: Bharati
authors.initials: B
authors.lastname: Sinha
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Yanyang
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Manning
authors.affiliation: Department of Neonatology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Thomas
authors.affiliation: Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Shuanhu
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Third Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530031, China.
authors.forename: He
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Daphne A
authors.initials: DA
authors.lastname: Kroessler
authors.affiliation: Third Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530031, China.
authors.forename: Jiemin
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.
authors.forename: Zhipu
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Terry E
authors.initials: TE
authors.lastname: Inder
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: xwang@rics.bwh.harvard.edu.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D015195:Drug Design; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology / Q000517:prevention & control*; D007231:Infant, Newborn; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D018696:Neuroprotective Agents