title: In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components.
abstract: The antibacterial potential of organic acids and essential oil components against Brachyspira hyodysenteriae, the causative pathogen of swine dysentery, was evaluated. Minimum inhibitory concentrations (MIC) of 15 compounds were determined at pH 7.2 and pH 6.0, using a broth microdilution assay. In addition, possible synergism was determined. MIC values for the three tested strains were similar. For organic acids, MIC values at pH 6.0 were lower than at pH 7.2. B. hyodysenteriae was most sensitive to cinnamaldehyde and lauric acid, with MIC values <1.5 mM. Most antibacterial effects of binary combinations were additive, however, for thymol and carvacrol, synergism could be observed. In vitro results demonstrate the antibacterial action of certain essential oil components and organic acids against B. hyodysenteriae.
authors.affiliation: Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
authors.forename: Lien
authors.initials: L
authors.lastname: Vande Maele
authors.forename: Marc
authors.initials: M
authors.lastname: Heyndrickx
authors.forename: Dominiek
authors.initials: D
authors.lastname: Maes
authors.forename: Nele
authors.initials: N
authors.lastname: De Pauw
authors.forename: Maxime
authors.initials: M
authors.lastname: Mahu
authors.forename: Marc
authors.initials: M
authors.lastname: Verlinden
authors.forename: Freddy
authors.initials: F
authors.lastname: Haesebrouck
authors.forename: An
authors.initials: A
authors.lastname: Martel
authors.forename: Frank
authors.initials: F
authors.lastname: Pasmans
authors.forename: Filip
authors.initials: F
authors.lastname: Boyen
mesh_terms: D000143:Acids / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017401:Brachyspira hyodysenteriae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000494:pharmacology*
chemical_list: D000143:Acids; D000900:Anti-Bacterial Agents; D009822:Oils, Volatile