title: A Randomized Controlled Trial of Personalized Text Message Reminders to Promote Medication Adherence Among HIV-Positive Adolescents and Young Adults.
abstract: HIV-positive adolescents and young adults often experience suboptimal medication adherence, yet few interventions to improve adherence in this group have shown evidence of efficacy. We conducted a randomized trial of a two-way, personalized daily text messaging intervention to improve adherence to antiretroviral therapy (ART) among N = 105 poorly adherent HIV-positive adolescents and young adults, ages 16-29. Adherence to ART was assessed via self-reported visual analogue scale (VAS; 0-100 %) at 3 and 6-months for mean adherence level and proportion ≥90 % adherent. The average effect estimate over the 6-month intervention period was significant for ≥90 % adherence (OR = 2.12, 95 % CI 1.01-4.45, p < .05) and maintained at 12-months (6 months post-intervention). Satisfaction scores for the intervention were very high. These results suggest both feasibility and initial efficacy of this approach. Given study limitations, additional testing of this intervention as part of a larger clinical trial with objective and/or clinical outcome measures of adherence is warranted.
authors.affiliation: Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Box 161, Chicago, IL, 60611, USA. rgarofalo@luriechildrens.org.|Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. rgarofalo@luriechildrens.org.
authors.forename: Robert
authors.initials: R
authors.lastname: Garofalo
authors.affiliation: Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Box 161, Chicago, IL, 60611, USA.|Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Kuhns
authors.affiliation: Division of Infectious Diseases, John H. Stroger Hospital of Cook County, Chicago, IL, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Hotton
authors.affiliation: Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Box 161, Chicago, IL, 60611, USA.|AIDS Foundation of Chicago, Chicago, IL, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Johnson
authors.affiliation: Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Box 161, Chicago, IL, 60611, USA.
authors.forename: Abigail
authors.initials: A
authors.lastname: Muldoon
authors.affiliation: Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Box 161, Chicago, IL, 60611, USA.
authors.forename: Dion
authors.initials: D
authors.lastname: Rice
mesh_terms: D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000523:psychology* / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008297:Male; D055118:Medication Adherence; D009042:Motivation; D017063:Outcome Assessment, Health Care; D010147:Pain Measurement; D010342:Patient Acceptance of Health Care; D017010:Reminder Systems; D020377:Self Efficacy; D060145:Text Messaging; D016896:Treatment Outcome; D055815:Young Adult
keywords: HIV infection; Medication adherence; Text messaging; Youth