title: The Potential Impact of Displacing Sedentary Time in Adults with Type 2 Diabetes.
abstract: OBJECTIVE
  Sedentary time, in particular, prolonged unbroken sedentary time, is detrimental to health and displaces time spent in either light or moderate intensity physical activity. This cross-sectional study aimed to identify the potential impact of reallocating time from sedentary behaviors to more active behaviors on measures of body composition and metabolic health in people with type 2 diabetes.
  
  
  METHODS
  Participants were 519 adults with newly diagnosed type 2 diabetes who had been recruited to the Early Activity in Diabetes (Early ACTID) randomized controlled trial. Waist-worn accelerometers were used to obtain objective measurement of sedentary time, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) at baseline alongside clinical measurements and fasting blood samples to determine cholesterol, triglycerides, HOMA-IR, and glucose. Isotemporal substitution modeling was performed to determine the potential impact of reallocating 30 min of sedentary time accumulated in a single bout (long bout) with 30 min of interrupted sedentary time, LPA, or MVPA.
  
  
  RESULTS
  Sedentary time accounted for 65% of the waking day, of which 45% was accumulated in prolonged (≥30 min) bouts. Reallocation of 30 min of long-bout sedentary time with 30 min of short-bout sedentary time was associated with lower body mass index (BMI) (adjusted β, -0.60; 95% confidence interval [CI], -1.00, -0.21) and waist circumference (WC) (adjusted β, -1.16; 95% CI, -2.08, -0.25). Stronger effects were seen for LPA and MVPA. Reallocation of 30 min of long-bout sedentary time with LPA was associated with higher HDL-cholesterol (adjusted β, 0.02; 95% CI, 0.00-0.03 mmol·L).
  
  
  CONCLUSIONS
  Encouraging adults with newly diagnosed type 2 diabetes to break up prolonged periods of sedentary time may be an effective strategy for improving body composition and metabolic health.
authors.affiliation: 1National Institute for Health Research, Biomedical Research Unit in Nutrition, Diet and Lifestyle, University of Bristol, Bristol, UNITED KINGDOM; 2Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, UNITED KINGDOM, and 3School of Clinical Sciences, University of Bristol, Bristol, UNITED KINGDOM.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Falconer
authors.forename: Angie S
authors.initials: AS
authors.lastname: Page
authors.forename: Rob C
authors.initials: RC
authors.lastname: Andrews
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Cooper
mesh_terms: D061725:Accelerometry; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides