title: Effect of early caffeine on neurodevelopmental outcome of very low-birth weight newborns.
abstract: OBJECTIVE
  The objective of this study is to evaluate the effect of early caffeine therapy started within the first 48 h of life on neurodevelopmental outcome in very low birth weight (VLBW) newborns.
  
  
  METHODS
  VLBW newborns received either caffeine therapy within first 48 h of life (Early group), after 3rd day of life (Late group) or no caffeine during first month of life as per clinical team. A cohort of these newborns (n = 160) who survived were evaluated using Bayley Scale of Infant Development III (BSID III) developmental testing between 18 and 22 months of corrected age.
  
  
  RESULTS
  VLBW newborns in the "Early group" had significantly better composite, cognitive, language and motor BSID III scores as compared to those in "Late group" and no caffeine group. Composite BSID III scores were unchanged in the presence or absence of chorioamnionitis for "Early group", while the BSID III scores were significantly lower in the presence of acute chorioamnionitis in "Late group" and no caffeine group.
  
  
  CONCLUSIONS
  Early caffeine therapy was associated with better BSID III scores in a cohort of VLBW newborns. Newborns with acute chorioamnionitis benefited from early caffeine therapy.
authors.affiliation: a Carman and Ann Adams Departments of Pediatrics, Wayne State University , Detroit , MI , USA and.
authors.forename: Avanti Sanjay
authors.initials: AS
authors.lastname: Gupte
authors.affiliation: a Carman and Ann Adams Departments of Pediatrics, Wayne State University , Detroit , MI , USA and.
authors.forename: Devyani
authors.initials: D
authors.lastname: Gupta
authors.affiliation: a Carman and Ann Adams Departments of Pediatrics, Wayne State University , Detroit , MI , USA and.
authors.forename: Saranya
authors.initials: S
authors.lastname: Ravichandran
authors.affiliation: a Carman and Ann Adams Departments of Pediatrics, Wayne State University , Detroit , MI , USA and.
authors.forename: Mia Michelle
authors.initials: MM
authors.lastname: Ma
authors.affiliation: a Carman and Ann Adams Departments of Pediatrics, Wayne State University , Detroit , MI , USA and.|b Division of Neonatal-Perinatal medicine, Carman and Ann Adams Departments of Pediatrics , Wayne State University , Detroit , MI , USA.
authors.forename: Nitin Shashikant
authors.initials: NS
authors.lastname: Chouthai
mesh_terms: D002110:Caffeine / Q000627:therapeutic use*; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002657:Child Development; D002821:Chorioamnionitis / Q000628:therapy; D002658:Developmental Disabilities / Q000517:prevention & control*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008297:Male; D009483:Neuropsychological Tests; D063868:Patient Outcome Assessment; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine
keywords: Caffeine; VLBW; chorioamnionitis; neurodevelopmental outcome