title: Thermo/pH Dual Responsive Mixed-Shell Polymeric Micelles Based on the Complementary Multiple Hydrogen Bonds for Drug Delivery.
abstract: Thermo/pH dual responsive mixed-shell polymeric micelles based on multiple hydrogen bonding were prepared by self-assembly of diaminotriazine-terminated poly(ɛ-caprolactone) (DAT-PCL), uracil-terminated methoxy poly(ethylene glycol) (MPEG-U), and uracil-terminated poly(N-vinylcaprolactam) (PNVCL-U) at room temperature. PCL acted as the core and MPEG/PNVCL as the mixed shell. Increasing the temperature, PNVCL collapsed and enclosed the PCL core, while MPEG penetrated through the PNVCL shell, thereby leading to the formation of MPEG channels on the micelles surface. The low cytotoxicity of the mixed micelles was confirmed by an MTT assay against BGC-823 cells. Studies on the in vitro drug release showed that a much faster release rate was observed at pH 5.0 compared to physiological pH, owing to the dissociation of hydrogen bonds. Therefore, the mixed-shell polymeric micelles would be very promising candidates in drug delivery systems.
authors.affiliation: Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China.
authors.forename: Qiuhua
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Tang
authors.affiliation: Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Liu
authors.affiliation: Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China.
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.affiliation: Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yang
authors.affiliation: Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yi
authors.affiliation: Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China.
authors.forename: Ximing
authors.initials: X
authors.lastname: Song
authors.affiliation: Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China. glzhang@lnu.edu.cn.
authors.forename: Guolin
authors.initials: G
authors.lastname: Zhang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems; D006801:Humans; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013696:Temperature
chemical_list: D008823:Micelles; D011108:Polymers; D004317:Doxorubicin
keywords: Core-shell-corona structures; drug delivery; hydrogen bonds; polymeric micelles; thermo/pH dual responsive