title: Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese.
abstract: OBJECTIVE
  RAD50-IL13 region has been recently identified as one of critical asthma susceptibility loci in genome-wide association studies, yet the role of these genetic variants or single-nucleotide polymorphisms (SNPs) in the risk of developing asthma in Northeastern Han Chinese remains largely unknown.
  
  
  METHODS
  We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method.
  
  
  RESULTS
  We did not find the allele or genotype frequency distribution of four SNPs in RAD50-IL13 region which was significantly different between asthmatic children and controls (p > 0.05).
  
  
  CONCLUSIONS
  Our findings first suggested that the variants in RAD50-IL13 region were not associated with asthma risk in Northeastern Han Chinese children.
authors.affiliation: a Department of Biochemistry and Molecular Biology , Harbin Medical University , Harbin , China .
authors.forename: Tianxiao
authors.initials: T
authors.lastname: Li
authors.affiliation: b Department of Pediatrics and.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Ren
authors.affiliation: c Department of Emergency , The Second Affiliated Hospital, Harbin Medical University , Harbin , China , and.
authors.forename: Ying
authors.initials: Y
authors.lastname: Deng
authors.affiliation: d Biotechnology Experimental Teaching Center, Harbin Medical University , Harbin , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Department of Biochemistry and Molecular Biology , Harbin Medical University , Harbin , China .
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zhou
mesh_terms: D017766:Acid Anhydride Hydrolases; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D045643:DNA Repair Enzymes / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D004268:DNA-Binding Proteins; C578095:IL13 protein, human; D018793:Interleukin-13; D017766:Acid Anhydride Hydrolases; C112158:RAD50 protein, human; D045643:DNA Repair Enzymes
keywords: Asthma; Han Chinese children; IL13; RAD50; single-nucleotide polymorphism