title: Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB.
abstract: High concentrations of arsenic, which can be occasionally found in drinking water, have been recognized as a global health problem. Exposure to arsenic can disrupt spatial memory; however, the underlying mechanism remains unclear. In the present study, we tested whether exercise could interfere with the effect of arsenic exposure on the long-term memory (LTM) of object recognition in mice. Arsenic (0, 1, 3, and 10 mg/ kg, i.g.) was administered daily for 12 weeks. We found that arsenic at dosages of 1, 3, and 10 mg/kg decreased body weight and increased the arsenic content in the brain. The object recognition LTM (tested 24 h after training) was disrupted by 3 mg/ kg and 10 mg/ kg, but not 1 mg/ kg arsenic exposure. Swimming exercise also prevented LTM impairment induced by 3 mg/ kg, but not with 10 mg/ kg, of arsenic exposure. The expression of brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP-response element binding protein (pCREB) in the CA1 and dentate gyrus areas (DG) of the dorsal hippocampus were decreased by 3 mg/ kg and 10 mg/ kg, but not by 1 mg/ kg, of arsenic exposure. The decrease in BDNF and pCREB in the CA1 and DG induced by 3 mg/ kg, but not 10 mg/ kg, of arsenic exposure were prevented by swimming exercise. Arsenic exposure did not affect the total CREB expression in the CA1 or DG. Taken together, these results indicated that swimming exercise prevented the impairment of object recognition LTM induced by arsenic exposure, which may be mediated by BDNF and CREB in the dorsal hippocampus.
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Bao-Fei
authors.initials: BF
authors.lastname: Sun
authors.affiliation: Department of Hospital Infection Management, Affiliated Hospital of Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Wang
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Yu
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Chao-Lun
authors.initials: CL
authors.lastname: Xiao
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Chao-Sheng
authors.initials: CS
authors.lastname: Kang
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Ge
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Linghu
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Jun-De
authors.initials: JD
authors.lastname: Zhu
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Li
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Qiang-Ming
authors.initials: QM
authors.lastname: Li
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Shi-Peng
authors.initials: SP
authors.lastname: Luo
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Dang
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Zhang
authors.affiliation: Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Tian
mesh_terms: D000818:Animals; D001151:Arsenic / Q000009:adverse effects* / Q000494:pharmacology; D001522:Behavior, Animal; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D050882:CREB-Binding Protein / Q000378:metabolism*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D057567:Memory, Long-Term / Q000187:drug effects; D051379:Mice; D010805:Physical Conditioning, Animal / Q000379:methods*; D013550:Swimming / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D050882:CREB-Binding Protein; C494364:Crebbp protein, mouse; D001151:Arsenic