title: miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis.
abstract: Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem affecting prognosis. Our recent study established that microRNA-506 (miR-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that miR-506 could augment the response to cisplatin and olaparib through targeting RAD51 and suppressing homologous recombination in a panel of ovarian cancer cell lines. Systemic delivery of miR-506 in an orthotopic ovarian cancer mouse model significantly augmented the cisplatin response, thus recapitulating the clinical observation. Therefore, miR-506 plays a functionally important role in homologous recombination and has important therapeutic value for sensitizing cancer cells to chemotherapy, especially in chemo-resistant patients with attenuated expression of miR-506.
authors.affiliation: Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, 300052, P.R. China. liuguoyan211@126.com.
authors.forename: Guoyan
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, 300052, P.R. China. fengxiaxue1962@163.com.
authors.forename: Fengxia
authors.initials: F
authors.lastname: Xue
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. wzhang@mdanderson.org.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D002945:Cisplatin; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm; D004359:Drug Therapy, Combination; D005260:Female; D059765:Homologous Recombination; D006801:Humans; D051379:Mice; D035683:MicroRNAs; D010051:Ovarian Neoplasms; D000077489:Piperazine; D010879:Piperazines; D011379:Prognosis; D051135:Rad51 Recombinase
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs; D010879:Piperazines; D000077489:Piperazine; D051135:Rad51 Recombinase; D002945:Cisplatin