title: Inulin as a novel biocompatible coating: evaluation of surface affinities toward CaHPO4, α-Fe2O3, ZnO, CaHPO4@ZnO and α-Fe2O3@ZnO nanoparticles.
abstract: The introduction of biocompatible coatings onto nanoparticle surfaces can be synthetically challenging. In this work, calcium phosphate (brushite, CaHPO4⋅2H2O), iron oxide (hematite, α-Fe2O3), zinc oxide (ZnO), and CaHPO4@ZnO and α-Fe2O3@ZnO nanoparticles were synthesized and treated with the biocompatible, biodegradable, polysaccharide inulin {(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxymethyl]-5-(hydroxymethyl)oxolane-2,3,4-triol} under mild conditions. The products were fully characterized by Fourier transforms infrared (FTIR) spectroscopy, energy dispersive spectroscopy (EDS), dynamic light scattering (DLS), differential thermogravimetric/differential thermal analysis (TGA/DTA), transmission electron microscopy (TEM) and powder X-ray diffraction (XRD). Surface interactions among hematite and brushite with inulin are weak, but coating the nanoparticle surface with ZnO increased the affinity toward the polysaccharide. Inulin adsorption on the nanoparticle surface was confirmed by thermal and spectroscopic analyses. The nanoparticles had diameters ranging from 50 to 80nm, with nearly spherical morphology. The nanoparticles sizes, stability and solubility in water could make them useful as components for enriched foods.
authors.affiliation: Departamento de Ingeniería Química, Alimentos y Ambiental, Universidad de las Américas Puebla, San Andres Cholula, Puebla 72820, Mexico. Electronic address: esmeralda.santillanua@udlap.mx.
authors.forename: E
authors.initials: E
authors.lastname: Santillán-Urquiza
authors.affiliation: Departamento de Ciencias Químico-Biológicas, Universidad de las Américas Puebla, San Andres Cholula, Puebla 72820, Mexico.
authors.forename: F
authors.initials: F
authors.lastname: Arteaga-Cardona
authors.affiliation: Centro de Servicios de Alta Tecnología, Universidad Popular Autónoma del Estado de Puebla, 15 Pte 1910, Barrio de Santiago, Puebla, Puebla 72410, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Hernandez-Herman
authors.affiliation: Centro de Servicios de Alta Tecnología, Universidad Popular Autónoma del Estado de Puebla, 15 Pte 1910, Barrio de Santiago, Puebla, Puebla 72410, Mexico. Electronic address: cesat@upaep.mx.
authors.forename: P F
authors.initials: PF
authors.lastname: Pacheco-García
authors.affiliation: Department of Chemistry, Texas Christian University, Fort Worth, TX 76129, USA.
authors.forename: R
authors.initials: R
authors.lastname: González-Rodríguez
authors.affiliation: Department of Chemistry, Texas Christian University, Fort Worth, TX 76129, USA. Electronic address: j.coffer@tcu.edu.
authors.forename: J L
authors.initials: JL
authors.lastname: Coffer
authors.affiliation: Instituto de Física "Luis Rivera Terrazas", Benemérita Universidad Autónoma de Puebla, Av. San Claudio y 18 Sur, Ciudad Universitaria, Puebla, Puebla 72570, Mexico. Electronic address: emendoza@ifuap.buap.mx.
authors.forename: M E
authors.initials: ME
authors.lastname: Mendoza-Alvarez
authors.affiliation: Departamento de Ingeniería Química, Alimentos y Ambiental, Universidad de las Américas Puebla, San Andres Cholula, Puebla 72820, Mexico.
authors.forename: J F
authors.initials: JF
authors.lastname: Vélez-Ruiz
authors.affiliation: Departamento de Ciencias Químico-Biológicas, Universidad de las Américas Puebla, San Andres Cholula, Puebla 72820, Mexico. Electronic address: miguela.mendez@udlap.mx.
authors.forename: M A
authors.initials: MA
authors.lastname: Méndez-Rojas
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002130:Calcium Phosphates / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D005527:Food, Fortified; D006801:Humans; D007444:Inulin / Q000737:chemistry*; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D010316:Particle Size; D011134:Polysaccharides / Q000737:chemistry; D011485:Protein Binding; D012542:Scattering, Radiation; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; D011134:Polysaccharides; D014867:Water; C000499:ferric oxide; D007444:Inulin; C020243:calcium phosphate; C494366:calcium phosphate, dibasic, dihydrate; D015034:Zinc Oxide
keywords: Calcium phosphate; Inulin; Iron oxide; Nanoparticles; Zinc oxide