title: No Dynamic Changes in Inflammation-related Microcirculatory Parameters in Developing Rats During Local Cortex Exposure to Microwaves.
abstract: The biological effects of exposing the developing brain to radiofrequency electromagnetic fields (RF) are still unclear. Our experiments investigated whether three inflammation-related, microcirculatory parameters in juvenile and young adult rats were modified during local cortex exposure to RF under non-thermal conditions. The cortex tissue was locally exposed to 1457 MHz RF at an averaged specific absorption rate of 2.0 W/kg in the target area for 50 min and variations of pial venule parameter were measured directly in vivo. There was no significant difference in hemodynamics, plasma velocity or vessel diameter, between exposed and sham-exposed groups for either rat development stage. No increase related to RF exposure was found in leukocyte adhesion to endothelial cells in any microvessels observed. These findings suggest that RF is unlikely to initiate inflammatory responses, at least under these exposure conditions.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan Department of Environmental Health, National Institute of Public Health, Saitama, Japan bdxmsd@yahoo.co.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Masuda
authors.affiliation: Department of Environmental Health, National Institute of Public Health, Saitama, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Hirota
authors.affiliation: Department of Environmental Health, National Institute of Public Health, Saitama, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ushiyama
authors.affiliation: Department of Computer Science and Engineering, Nagoya Institute of Technology, Aichi, Japan.
authors.forename: Akimasa
authors.initials: A
authors.lastname: Hirata
authors.affiliation: Department of Electrical and Electronics Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Arima
authors.affiliation: Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Tokyo, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawai
authors.affiliation: Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Tokyo, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Wake
authors.affiliation: Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Tokyo, Japan.
authors.forename: Soichi
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: Department of Electrical and Electronic Engineering, Tokyo Metropolitan University, Tokyo, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Taki
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nagai
authors.affiliation: Japan EMF Information Center, Tokyo, Japan.
authors.forename: Chiyoji
authors.initials: C
authors.lastname: Ohkubo
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002448:Cell Adhesion; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology / Q000528:radiation effects*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D006439:Hemodynamics; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology*; D036904:Leukocyte Rolling; D007962:Leukocytes / Q000502:physiology; D008297:Male; D008833:Microcirculation; D008872:Microwaves; D051381:Rats; D013696:Temperature
keywords: Radiofrequency electromagnetic field; adhesion; developing stage; hemodynamics; leukocyte; local exposure; plasma velocity; vessel diameter; young adult rats