title: MGH-USC Human Connectome Project datasets with ultra-high b-value diffusion MRI.
abstract: The MGH-USC CONNECTOM MRI scanner housed at the Massachusetts General Hospital (MGH) is a major hardware innovation of the Human Connectome Project (HCP). The 3T CONNECTOM scanner is capable of producing a magnetic field gradient of up to 300 mT/m strength for in vivo human brain imaging, which greatly shortens the time spent on diffusion encoding, and decreases the signal loss due to T2 decay. To demonstrate the capability of the novel gradient system, data of healthy adult participants were acquired for this MGH-USC Adult Diffusion Dataset (N=35), minimally preprocessed, and shared through the Laboratory of Neuro Imaging Image Data Archive (LONI IDA) and the WU-Minn Connectome Database (ConnectomeDB). Another purpose of sharing the data is to facilitate methodological studies of diffusion MRI (dMRI) analyses utilizing high diffusion contrast, which perhaps is not easily feasible with standard MR gradient system. In addition, acquisition of the MGH-Harvard-USC Lifespan Dataset is currently underway to include 120 healthy participants ranging from 8 to 90 years old, which will also be shared through LONI IDA and ConnectomeDB. Here we describe the efforts of the MGH-USC HCP consortium in acquiring and sharing the ultra-high b-value diffusion MRI data and provide a report on data preprocessing and access. We conclude with a demonstration of the example data, along with results of standard diffusion analyses, including q-ball Orientation Distribution Function (ODF) reconstruction and tractography.
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Qiuyun
authors.initials: Q
authors.lastname: Fan
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Witzel
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Aapo
authors.initials: A
authors.lastname: Nummenmaa
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA; Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA, USA.
authors.forename: Koene R A
authors.initials: KRA
authors.lastname: Van Dijk
authors.affiliation: Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Van Horn
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA; Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA, USA.
authors.forename: Michelle K
authors.initials: MK
authors.lastname: Drews
authors.affiliation: Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA, USA.
authors.forename: Leah H
authors.initials: LH
authors.lastname: Somerville
authors.affiliation: Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Sheridan
authors.affiliation: Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Rosario M
authors.initials: RM
authors.lastname: Santillana
authors.affiliation: Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Jenna
authors.initials: J
authors.lastname: Snyder
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Trey
authors.initials: T
authors.lastname: Hedden
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Emily E
authors.initials: EE
authors.lastname: Shaw
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA; Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA, USA.
authors.forename: Marisa O
authors.initials: MO
authors.lastname: Hollinshead
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA; Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.
authors.forename: Ville
authors.initials: V
authors.lastname: Renvall
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Roberta
authors.initials: R
authors.lastname: Zanzonico
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Boris
authors.initials: B
authors.lastname: Keil
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Cauley
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Polimeni
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Dylan
authors.initials: D
authors.lastname: Tisdall
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA; Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA, USA.
authors.forename: Randy L
authors.initials: RL
authors.lastname: Buckner
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA.
authors.forename: Van J
authors.initials: VJ
authors.lastname: Wedeen
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: Lawrence L
authors.initials: LL
authors.lastname: Wald
authors.affiliation: Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown 02129, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: bruce@nmr.mgh.harvard.edu.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Rosen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D002648:Child; D063132:Connectome; D016208:Databases, Factual; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D033181:Information Dissemination; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: Adolescents; Children; Lifespan; Multi-shell HARDI; Older adults; Preprocessing