title: Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio).
abstract: Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A-C (1-3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1-5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish.
authors.affiliation: Graduate School of Biotechnology, Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Republic of Korea.
authors.forename: Kyeong-Hwa
authors.initials: KH
authors.lastname: Seo
authors.affiliation: Graduate School of Biotechnology, Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Republic of Korea.
authors.forename: Youn-Hee
authors.initials: YH
authors.lastname: Nam
authors.affiliation: Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Republic of Korea.
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Lee
authors.affiliation: Department of Herbal Foodceutical Science, Daegu Haany University, Gyeongsan 712-715, Republic of Korea.
authors.forename: Eun-Mi
authors.initials: EM
authors.lastname: Ahn
authors.affiliation: Graduate School of Biotechnology, Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Republic of Korea.
authors.forename: Tong-Ho
authors.initials: TH
authors.lastname: Kang
authors.affiliation: Graduate School of Biotechnology, Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Republic of Korea. Electronic address: nibaek@khu.ac.kr.
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
mesh_terms: D000496:Alloxan / Q000009:adverse effects*; D000818:Animals; D019610:Cytoprotection / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects*; D031566:Magnolia / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry; D015027:Zebrafish
chemical_list: D006027:Glycosides; D020005:Propanols; C439395:1-phenylpropanol; D000496:Alloxan
keywords: Alloxan; Anti-diabetic; Magnolia obovata; Obovatoside; Pancreatic islet; Zebrafish