title: The Impact of Chemotherapy on Hepatitis B Antibody Titer in Patients with Hematological Malignancies.
abstract: OBJECTIVE
  To investigate the influence of chemotherapy (CT) on HBsAb titer in patients receiving CT due to hematological malignancy.
  
  
  METHODS
  The data of 75 patients who received CT with the diagnosis of various hematological malignancies and who had serum HBsAb levels measured prior to and after the cessation of CT were evaluated retrospectively.
  
  
  RESULTS
  The median age of the patients was 52 years (range: 16-78) with 49 (65%) males and 26 (35%) females. Median HBsAb titer decreased significantly after CT compared to the pre-CT median HBsAb titer [68 (range: 0-1000) vs. 100 (range: 6.2-1000)] (p=0.001). In subgroup analysis, median HBsAb titer decreased significantly after CT in acute leukemia patients [110 (range: 6.2-1000) vs. 67.8 (range: 0-1000)] (p=0.003) and in patients receiving intensive CT [97.2 (range: 6.2-1000) vs. 71 (range: 0-1000)] (p=0.036). The decrease in median HBsAb titer was significant in male patients (p<0.001). HBsAb became negative after CT in 9 patients who were HBcAb-negative and had lower pre-CT HBsAb levels.
  
  
  CONCLUSIONS
  HBsAb decreased after CT, especially in acute leukemia and male patients, and in patients receiving intensive CT.
authors.affiliation: Gazi University Faculty of Medicine, Department of Hematology, Ankara, Turkey Phone: +90 312 202 63 17 E-mail: ayagci@gazi.edu.tr.
authors.forename: Münci
authors.initials: M
authors.lastname: Yağcı
authors.forename: Elif
authors.initials: E
authors.lastname: Suyanı
authors.forename: Merih
authors.initials: M
authors.lastname: Kızıl Çakar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D005260:Female; D019337:Hematologic Neoplasms / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014775:Virus Activation / Q000276:immunology; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens