title: Association between serum adropin levels and gestational diabetes mellitus; a case-control study.
abstract: Gestational diabetes mellitus (GDM) is increasing worldwide. The aim of this study was to investigate the association between serum adropin concentration and GDM. In a case-control study, conducted in 2013, 40 pregnant women with GDM and 40 healthy pregnant women (controls) were evaluated. Fasting serum adropin and lipid concentration were measured during 24th-28th weeks of gestation for both groups. These factors were compared between the two groups using independent sample t-test. There was a significant difference in adropin levels between the two groups and mean adropin levels were lower in GDM group (p: 0.016). There was no significant correlation between serum adropin levels and body mass index as well as fasting blood glucose (FBS) or serum lipid profile including high-density lipoprotein, low-density lipoprotein, cholesterol and triglyceride concentration (p > 0.05). There was a significant association between adropin concentration and GDM even after using regression model for removing confounding factors (odds ratio = 0.681). Low serum adropin concentration is associated with GDM in Iranian pregnant women.
authors.affiliation: a Arash Hospital, Tehran University of Medical Sciences , Tehran , Iran .
authors.forename: Aboutaleb
authors.initials: A
authors.lastname: Beigi
authors.affiliation: b Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences , Tehran , Iran .
authors.forename: Nooshin
authors.initials: N
authors.lastname: Shirzad
authors.affiliation: c Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences , Tehran , Iran , and.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Nikpour
authors.affiliation: c Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences , Tehran , Iran , and.
authors.forename: Ensieh
authors.initials: E
authors.lastname: Nasli Esfahani
authors.affiliation: d Department of Clinical Biochemistry , School of Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Solaleh
authors.initials: S
authors.lastname: Emamgholipour
authors.affiliation: b Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences , Tehran , Iran .|c Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences , Tehran , Iran , and.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Bandarian
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005215:Fasting; D005260:Female; D005865:Gestational Age; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007492:Iran; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D010455:Peptides / Q000097:blood*; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010455:Peptides; D014280:Triglycerides
keywords: Adropin; gestational diabetes mellitus; metabolic disorders; pregnancy