title: C-H functionalization at sterically congested positions by the platinum-catalyzed borylation of arenes.
abstract: Despite significant progress in the area of C-H bond functionalization of arenes, no general method has been reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, we report the development of the first platinum-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to a series of 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, and ‡Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Furukawa
authors.affiliation: ESICB, Kyoto University , Katsura, Kyoto 615-8510, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tobisu
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, and ‡Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Chatani