title: Case Report: Hemolytic Anemia Following Deceased Donor Renal Transplantation Associated With Tranexamic Acid Administration for Disseminated Intravascular Coagulation.
abstract: BACKGROUND
  Long-term outcomes of kidney transplantation with organs from donors with disseminated intravascular coagulation (DIC) are comparable with those from other deceased donors. The use of tranexamic acid to impair fibrinolysis in the treatment of DIC is becoming increasingly frequent, particularly in the trauma setting. However, the effects of tranexamic acid on a transplanted kidney allograft are unknown.
  
  
  RESULTS
  We report 2 cases of kidney transplantation following administration of tranexamic acid to the donor prior to organ donation. Microthrombi were present in the renal allografts. Both recipients experienced clinically significant hemolytic anemia, which typically occurs at a very low frequency.
  
  
  CONCLUSIONS
  These cases illustrate a potential concern for the use of tranexamic acid in deceased kidney donors with DIC.
authors.affiliation: Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA; Department of Pharmacy Services, B-069, Jackson Memorial Hospital, Miami, Florida, USA.
authors.forename: J Y
authors.initials: JY
authors.lastname: Revollo
authors.affiliation: Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Cuffy
authors.affiliation: Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Witte
authors.affiliation: Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
authors.forename: F
authors.initials: F
authors.lastname: Paterno
authors.affiliation: Division of Nephrology, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Alloway
authors.affiliation: Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA. Electronic address: woodlees@uc.edu.
authors.forename: E S
authors.initials: ES
authors.lastname: Woodle
mesh_terms: D000368:Aged; D000743:Anemia, Hemolytic / Q000150:complications / Q000175:diagnosis*; D000933:Antifibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005342:Fibrinolysis; D005921:Glomerulonephritis / Q000150:complications / Q000601:surgery*; D006801:Humans; D006973:Hypertension / Q000150:complications; D007668:Kidney / Q000187:drug effects; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000150:complications / Q000175:diagnosis*; D014019:Tissue Donors; D014148:Tranexamic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid