title: Hypothetical Atopic Dermatitis-Myeloproliferative Neoplasm Syndrome.
abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Myeloproliferative neoplasms (MPNs) are hematopoietic malignancies caused by uncontrolled proliferation of hematopoietic stem/progenitor cells. Recent studies have described several mutant mice exhibiting both AD-like skin inflammation and MPN. Common pathways for skin inflammation encompass overexpression of thymic stromal lymphopoietin and reduced signaling of epidermal growth factor receptor in the epidermis, while overproduction of granulocyte-colony-stimulating factor by keratinocytes and constitutive activation of Stat5 in hematopoietic stem cells are important for the development of MPN. The murine studies suggest the existence of a similar human disease tentatively termed as the atopic dermatitis-myeloproliferative neoplasm syndrome.
authors.affiliation: Division of Cell Biology, La Jolla Institute for Allergy and Immunology , La Jolla, CA , USA ; Laboratory for Allergic Disease, RIKEN Center for Integrative Medical Sciences (IMS-RCAI) , Yokohama , Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kawakami
authors.affiliation: Laboratory for Allergic Disease, RIKEN Center for Integrative Medical Sciences (IMS-RCAI) , Yokohama , Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ando
authors.affiliation: Division of Cell Biology, La Jolla Institute for Allergy and Immunology , La Jolla, CA , USA.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kawakami
keywords: atopic dermatitis; hematopoietic stem cell; mast cell; mouse models; myeloproliferative neoplasm