title: Prevalence of chronic kidney disease and its association with cardio-metabolic risk factors in the adult Romanian population: the PREDATORR study.
abstract: OBJECTIVE
  PREDATORR is the first national study analyzing the prevalence of chronic kidney disease and its prognosis and association with socio-demographic, cardio-metabolic and lifestyle risk factors in the adult Romanian population.
  
  
  METHODS
  Chronic kidney disease was defined according to the KDIGO 2012 criteria as an estimated glomerular filtration rate <60 mL/min/1.73 m(2) and/or urinary albumin-to-creatinine ratio ≥30 mg/g. The socio-demographic, lifestyle and anamnestic data were collected through interviewer-administered questionnaires. Physical examination and biochemical assays were also performed.
  
  
  RESULTS
  This cross-sectional study conducted between December 2012 and February 2014 in Romania included 2717 adults. The overall age- and sex-adjusted prevalence of chronic kidney disease was 6.74 % (95 %CI 5.60-7.88 %), of which 3.31 % (2.50-4.13 %) had only reduced kidney function (estimated glomerular filtration rate <60 mL/min/1.73 m(2)), 2.98 % (2.21-3.76 %) had only albuminuria, and 0.45 % (0.14-0.74 %) had both. The prevalence of chronic kidney disease increased with age and was similar in women and in men. Age, hyperuricemia, impaired glucose regulation (diabetes/prediabetes), hypertriglyceridemia and a family history of renal disease were independent risk factors for the presence of chronic kidney disease.
  
  
  CONCLUSIONS
  The PREDATORR study showed a high prevalence of chronic kidney disease in the adult Romanian population providing data on its prognosis and association with several cardio-metabolic risk factors.
authors.affiliation: Department of Nephrology, University of Medicine and Pharmacy Craiova, 2-4 Petru Rares Street, Craiova, Romania.
authors.forename: Eugen
authors.initials: E
authors.lastname: Moţa
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, 2-4 Petru Rares Street, Craiova, Romania.
authors.forename: Simona Georgiana
authors.initials: SG
authors.lastname: Popa
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, 2-4 Petru Rares Street, Craiova, Romania. mmota53@yahoo.com.|Emergency Clinical Hospital Craiova, Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, Romania, 1 Tabaci Street, Craiova, Romania. mmota53@yahoo.com.
authors.forename: Maria
authors.initials: M
authors.lastname: Moţa
authors.affiliation: Emergency Clinical Hospital Craiova, Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, Romania, 1 Tabaci Street, Craiova, Romania.
authors.forename: Adina
authors.initials: A
authors.lastname: Mitrea
authors.affiliation: Department of Nephrology, University of Medicine and Pharmacy "Carol Davila" Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania.
authors.forename: Mircea
authors.initials: M
authors.lastname: Penescu
authors.affiliation: Department of Nephrology, University "Ovidius" Constanta, 1 Aleea Universitatii, Constanta, Romania.
authors.forename: Liliana
authors.initials: L
authors.lastname: Tuţă
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Carol Davila" Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania.
authors.forename: Cristian
authors.initials: C
authors.lastname: Serafinceanu
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, 2-4 Clinicilor Street, Cluj-Napoca, Romania.
authors.forename: Nicolae
authors.initials: N
authors.lastname: Hâncu
authors.affiliation: Department of Nephrology, University of Medicine and Pharmacy "Carol Davila" Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania.
authors.forename: Liliana
authors.initials: L
authors.lastname: Gârneaţă
authors.affiliation: Department of Nephrology, University of Medicine and Pharmacy "Carol Davila" Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania.
authors.forename: Constantin
authors.initials: C
authors.lastname: Verzan
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Carol Davila" Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania.
authors.forename: Radu
authors.initials: R
authors.lastname: Lichiardopol
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Carol Davila" Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Zetu
authors.affiliation: Department of Nephrology, University of Medicine and Pharmacy "Carol Davila" Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Căpuşă
authors.affiliation: Department of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, 2 Victor Babes Street, Cluj-Napoca, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Vlăduţiu
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Carol Davila" Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania.
authors.forename: Cristian
authors.initials: C
authors.lastname: Guja
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University "Ovidius" Constanta, 1 Aleea Universitatii, Constanta, Romania.
authors.forename: Doina
authors.initials: D
authors.lastname: Catrinoiu
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, 2-4 Clinicilor Street, Cluj-Napoca, Romania.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Bala
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, 2-4 Clinicilor Street, Cluj-Napoca, Romania.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Roman
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Carol Davila" Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Radulian
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Victor Babes" Timisoara, 2 Piata Eftimie Murgu, Timisoara, Romania.
authors.forename: Romulus
authors.initials: R
authors.lastname: Timar
authors.affiliation: Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy "Grigore T. Popa" Iasi, 16 Universitatii Street, Iasi, Romania.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Mihai
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000419:Albuminuria / Q000209:etiology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D015228:Hypertriglyceridemia / Q000453:epidemiology; D033461:Hyperuricemia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D055815:Young Adult
keywords: Cardio-metabolic risk factors; Chronic kidney disease; Epidemiology; PREDATORR; Romania