title: Multifaceted role of β-arrestins in inflammation and disease.
abstract: Arrestins are intracellular scaffolding proteins known to regulate a range of biochemical processes including G protein-coupled receptor (GPCR) desensitization, signal attenuation, receptor turnover and downstream signaling cascades. Their roles in regulation of signaling network have lately been extended to receptors outside of the GPCR family, demonstrating their roles as important scaffolding proteins in various physiological processes including proliferation, differentiation and apoptosis. Recent studies have demonstrated a critical role for arrestins in immunological processes including key functions in inflammatory signaling pathways. In this review, we provide a comprehensive analysis of the different functions of the arrestin family of proteins especially related to immunity and inflammatory diseases.
authors.affiliation: Department of Physiology and Division of Pathology, Michigan State University, East Lansing, MI, USA.
authors.forename: D
authors.initials: D
authors.lastname: Sharma
authors.affiliation: Department of Physiology and Division of Pathology, Michigan State University, East Lansing, MI, USA.
authors.forename: N
authors.initials: N
authors.lastname: Parameswaran
mesh_terms: D000818:Animals; D019390:Arrestins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology*; D015398:Signal Transduction; D000071557:beta-Arrestins
chemical_list: D019390:Arrestins; D000071557:beta-Arrestins