title: A novel eye drop application monitor to assess patient compliance with a prescribed regimen: a pilot study.
abstract: OBJECTIVE
  To assess the ability of a novel imaging device to allow physicians to personalize therapeutic regimens based on objective patient drop administration data.
  
  
  METHODS
  A novel imaging system was used to record video of the drop technique of subjects in clinic (n=25) or at home (n=17) for 1 week. Video assessment by a reading center was compared with patient reporting and their prescribed regimen with respect to how many drops were applied and how many landed in the eye.
  
  
  RESULTS
  Reading center assessment of both drops dispensed and drops landing in the eye was significantly different from the prescribed regimen in the clinic (Pd=0.005, Pi<0.001, respectively) and at-home arms (Pd=0.003, Pi<0.001, respectively).
  
  
  CONCLUSIONS
  This imaging system is a powerful tool to help physicians tailor patient therapy more accurately, to help researchers evaluate new drop therapies with objective rather than subjective data, and to potentially facilitate better patient training for improved drug delivery.
authors.affiliation: Retina Health Center, Fort Myers, FL, USA.|EDIT Systems Inc., Fort Myers, FL, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Eaton
authors.affiliation: Retina Health Center, Fort Myers, FL, USA.|EDIT Systems Inc., Fort Myers, FL, USA.|California Retina Consultants, Santa Barbara, CA, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Gordon
authors.affiliation: Konowal Vision Center, Fort Myers, FL, USA.
authors.forename: A
authors.initials: A
authors.lastname: Konowal
authors.affiliation: Konowal Vision Center, Fort Myers, FL, USA.
authors.forename: A
authors.initials: A
authors.lastname: Allen
authors.affiliation: Konowal Vision Center, Fort Myers, FL, USA.
authors.forename: M
authors.initials: M
authors.lastname: Allen
authors.affiliation: Retina Health Center, Fort Myers, FL, USA.
authors.forename: A
authors.initials: A
authors.lastname: Sgarlata
authors.affiliation: Retina Health Center, Fort Myers, FL, USA.|EDIT Systems Inc., Fort Myers, FL, USA.
authors.forename: G
authors.initials: G
authors.lastname: Gao
authors.affiliation: Retina Health Center, Fort Myers, FL, USA.|EDIT Systems Inc., Fort Myers, FL, USA.
authors.forename: H
authors.initials: H
authors.lastname: Wafapoor
authors.affiliation: EDIT Systems Inc., Fort Myers, FL, USA.|California Retina Consultants, Santa Barbara, CA, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Avery
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009883:Ophthalmic Solutions; D010865:Pilot Projects; D011446:Prospective Studies; D012646:Self Administration; D011795:Surveys and Questionnaires; D014741:Video Recording / Q000295:instrumentation*; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions