title: A Review of Hematopoietic Cell Transplantation in Australia and New Zealand, 2005 to 2013.
abstract: This report describes hematopoietic cell transplantation (HCT) activity and outcome in Australia and New Zealand during the years 2005 to 2013. In 2013, 1018 autologous, 221 allogeneic with related donors, and 264 allogeneic with unrelated donors HCT were performed in 40 centers in Australia, with corresponding figures of 147, 39, and 47 in 6 centers in New Zealand. Annual numbers of HCT in 2013 increased, compared to 2005, by 25% in Australia and by 52% in New Zealand. The majority of both allogeneic and autologous HCT used peripheral blood as the stem cell source for all years studied. Major indications for transplantation were acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), plasma cell disorders, and non-Hodgkin lymphoma (NHL). Overall survival probabilities at 5 years after transplantation for adult (16+) allogeneic first HCT recipients were 54.2% for ALL, 46.0% for AML, 48.4% for myelodysplastic syndromes, and 58.6% for NHL. Consistent patterns over time include a steady increase in HCT, particularly for older recipients, relatively constant numbers of allografts using cord blood, and a recent increase in the number of allografts with 2 or more HLA-mismatched related donors.
authors.affiliation: Australasian Bone Marrow Transplant Recipient Registry, Darlinghurst, NSW, Australia. Electronic address: Ian.Nivison-Smith@svha.org.au.
authors.forename: Ian
authors.initials: I
authors.lastname: Nivison-Smith
authors.affiliation: Central Adelaide Local Health Network, South Australia Health, South Australia, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Bardy
authors.affiliation: Department of Haematology and SCT, St. Vincent's Hospital, Darlinghurst, NSW, Australia.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Dodds
authors.affiliation: Department of Haematology and SCT, St. Vincent's Hospital, Darlinghurst, NSW, Australia.
authors.forename: David D F
authors.initials: DDF
authors.lastname: Ma
authors.affiliation: Australasian Bone Marrow Transplant Recipient Registry, Darlinghurst, NSW, Australia.
authors.forename: Donna
authors.initials: D
authors.lastname: Aarons
authors.affiliation: Australasian Bone Marrow Transplant Recipient Registry, Darlinghurst, NSW, Australia.
authors.forename: Steven
authors.initials: S
authors.lastname: Tran
authors.affiliation: Australasian Bone Marrow Transplant Recipient Registry, Darlinghurst, NSW, Australia.
authors.forename: Leonie
authors.initials: L
authors.lastname: Wilcox
authors.affiliation: Department of Haematology and BMT, Royal Melbourne Hospital, Parkville, Victoria, Australia.
authors.forename: Jeff
authors.initials: J
authors.lastname: Szer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001315:Australia; D002648:Child; D002675:Child, Preschool; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D049674:History, 21st Century; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009520:New Zealand; D019172:Transplantation Conditioning / Q000379:methods* / Q000401:mortality; D055815:Young Adult
keywords: Australia; Hematopoietic cell transplantation; New Zealand