title: Determinants of advanced stage presentation of breast cancer in 87,969 Brazilian women.
abstract: BACKGROUND
  Breast cancer is commonly diagnosed at an advanced stage in Brazil.
  
  
  OBJECTIVE
  Analyze the determinants of advanced staging in Brazilian women with breast cancer.
  
  
  METHODS
  Crosssectional study, including women diagnosed with breast cancer in Brazil, between 2000 and 2009.
  
  
  RESULTS
  A total of 59,317 women were included, 53.5% being classified as advanced stage (≥IIB). Younger age (18 to 49 years old) (OR=1.61 95% CI 1.51 to 1.72) or between 40 and 49 years old (OR=1.08 95% CI 1.03 to 1.14), having low educational level (OR=1.53 95% CI 1.48 to 1.58), living in less developed geographical regions (OR=1.27 95% CI 1.21 to 1.33), having invasive ductal carcinoma (OR=2.70 95% CI 2.56 to 2.84) and invasive lobular carcinoma (OR=2.63 95% CI 2.42 to 2.86) were associated with advanced breast cancer.
  
  
  CONCLUSIONS
  We conclude that future interventions should focus on these high risk groups.
authors.affiliation: Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil. Electronic address: karen.abrahao@gmail.com.
authors.forename: Karen de Souza
authors.initials: Kde S
authors.lastname: Abrahão
authors.affiliation: Brazilian National Cancer Institute (INCA) and University Center Augusto Motta (UNISUAM), Rio de Janeiro, Brazil. Electronic address: abergmann@inca.gov.br.
authors.forename: Anke
authors.initials: A
authors.lastname: Bergmann
authors.affiliation: Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil. Electronic address: saguiar@inca.gov.br.
authors.forename: Suzana Sales de
authors.initials: SS
authors.lastname: Aguiar
authors.affiliation: Brazilian National Cancer Institute (INCA) and Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil. Electronic address: lthuler@inca.gov.br.
authors.forename: Luiz Claudio Santos
authors.initials: LC
authors.lastname: Thuler
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000473:pathology*; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data*; D012111:Residence Characteristics; D055815:Young Adult
keywords: Advanced stage; Brazil; Breast cancer; Epidemiology; Hospital cancer registries