title: Pd(II) -Catalyzed Intermolecular Amination of Unactivated C(sp(3) )-H Bonds.
abstract: Pd(II) -catalyzed intermolecular amination of unactivated C(sp(3) )-H bonds has been successfully developed for the first time. This method provides a new way to achieve the challenging intermolecular amination of unactivated C(sp(3) )-H bonds, producing a variety of unnatural β(2) -amino carboxylic acid analogues. This C(sp(3) )-H amination protocol is demonstrated with a broad substrate scope, good functional-group tolerance, and chemoselectivity. It is operated without use of phosphine ligand or external oxidant.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, 650091 (P.R. China).
authors.forename: Quan
authors.initials: Q
authors.lastname: Gou
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, 650091 (P.R. China).
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, 650091 (P.R. China).
authors.forename: Zi-Ning
authors.initials: ZN
authors.lastname: Liu
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, 650091 (P.R. China). qinjun@ynu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Qin
keywords: C(sp3)H activation; amination; cross-coupling; palladium; β-amino acids