title: Diminished Utilization of in Vitro Fertilization Following Ovarian Transposition in Cervical Cancer Patients.
abstract: OBJECTIVE
  To assess subsequent utilization of fertility treatment in reproductive-age women with cervical cancer (CC) who underwent ovarian transposition (OT) to preserve fertility prior to pelvic radiation.
  
  
  METHODS
  This is a case series of 216 CC patients seen in a comprehensive cancer center. Sixteen patients underwent OT for fertility preservation prior to pelvic radiation. Patients were assessed for utilization of fertility treatment, follicle-stimulating hormone (FSH) levels as a measure of ovarian reserve, and functional assessment of chronic illness therapy-cervix cancer (FACT-CX) to assess quality of life after OT.
  
  
  RESULTS
  Of the patients, 94% of patients [corrected] maintained regular menstrual cycles 3 years after ovarian transposition (OT) [corrected] surgery (15/16). When measured (n = 5), serum FSH was normal at baseline and showed a transient elevation at 3 months following chemoradiation, with a return to normal levels at 6 months (means, 6.33 ± 2.94, 48.44 ± 18.63, and 12.52 ± 8.25 mIU/mL, respectively). Only 1 patient in this series attempted fertility treatment (in vitro fertilization) following OT, and she did not become pregnant. FACT-CX indicated that quality of life did not change significantly over the 6 months' duration following OT and chemoradiation therapy.
  
  
  CONCLUSIONS
  OT preserves menstrual cycle regularity without negatively impacting patients' quality of life. The utility of OT as an effective fertility preservation option is hampered by the low utilization rate of in vitro fertilization and lack of ovarian reserve assessment following OT.
authors.forename: Sana M
authors.initials: SM
authors.lastname: Salih
authors.forename: Samet
authors.initials: S
authors.lastname: Albayrak
authors.forename: Songwon
authors.initials: S
authors.lastname: Seo
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Stewart
authors.forename: Kristen
authors.initials: K
authors.lastname: Bradley
authors.forename: David M
authors.initials: DM
authors.lastname: Kushner
mesh_terms: D000328:Adult; D005260:Female; D059247:Fertility Preservation / Q000379:methods / Q000706:statistics & numerical data*; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy* / Q000601:surgery*; D055815:Young Adult