title: Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.
abstract: OBJECTIVE
  A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients.
  
  
  METHODS
  A retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry.
  
  
  RESULTS
  A total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55-68.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23-100.48).
  
  
  CONCLUSIONS
  UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.
authors.affiliation: Division of Urology, European Institute of Oncology, Milan, Italy.|Department of Urology, 'Iuliu Hatieganu' University of Medicine & Pharmacy, Cluj-Napoca, Romania.
authors.forename: Ottavio
authors.initials: O
authors.lastname: De Cobelli
authors.affiliation: Oncologia Urologica, Dipartimento di Medicina Clinica e Chirurgia, Azienda Ospedaliera Universitaria 'Federico II', Napoli, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Buonerba
authors.affiliation: Department of Translational Medical Sciences, University 'Federico II', Naples, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Terracciano
authors.affiliation: Division of Urology, European Institute of Oncology, Milan, Italy.
authors.forename: Danilo
authors.initials: D
authors.lastname: Bottero
authors.affiliation: Department of Emergency & Organ Transplantation - Urology, Andrology & Kidney Transplantation Unit, University of Bari, Bari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lucarelli
authors.affiliation: Department of Urology, Tor Vergata University of Rome, V.le Oxford 81, Rome, 00133, Italy.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Bove
authors.affiliation: Department of Urology of San Giovanni di Dio & Ruggi d'Aragona Hospital, University of Salerno, Salerno, SA, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Altieri
authors.affiliation: Department of Urology, 'Iuliu Hatieganu' University of Medicine & Pharmacy, Cluj-Napoca, Romania.
authors.forename: Ioman
authors.initials: I
authors.lastname: Coman
authors.affiliation: Department of Urology, National Cancer Institute of Naples, Naples, Italy.
authors.forename: Sisto
authors.initials: S
authors.lastname: Perdonà
authors.affiliation: Gineco-urological Department, National Cancer Institute of Naples 'Fondazione G Pascale', Naples, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Facchini
authors.affiliation: Department of Medical Oncology, National Cancer Institute, Aviano, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Berretta
authors.affiliation: Oncologia Urologica, Dipartimento di Medicina Clinica e Chirurgia, Azienda Ospedaliera Universitaria 'Federico II', Napoli, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Lorenzo
authors.affiliation: Department of Pharmacy, University of Naples, Federico II, Naples 80131, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Grieco
authors.affiliation: Department of Pharmacy, University of Naples, Federico II, Naples 80131, Italy.
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
authors.affiliation: Pathology Unit, National Cancer Institute 'Fondazione G. Pascale', Naples, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Franco
authors.affiliation: Department of Biochemistry, Biophysics & General Pathology, Second University of Naples, Naples, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Caraglia
authors.affiliation: Division of Pathology, Giovanni Bosco Hospital, Turin, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Manini
authors.affiliation: Urology Division, University Federico II of Naples, Napoli, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Mirone
authors.affiliation: Oncologia Urologica, Dipartimento di Medicina Clinica e Chirurgia, Azienda Ospedaliera Universitaria 'Federico II', Napoli, Italy.
authors.forename: Sabino
authors.initials: S
authors.lastname: De Placido
authors.affiliation: UAB (University of Alabama at Birmingham) Cancer Center, Birmingham, AL 35233, USA.
authors.forename: Guru
authors.initials: G
authors.lastname: Sonpavde
authors.affiliation: Division of Urology, European Institute of Oncology, Milan, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Ferro
mesh_terms: D000368:Aged; D001706:Biopsy; D018450:Disease Progression; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D057234:Preoperative Period; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D043562:Receptors, G-Protein-Coupled; C121697:UTS2R protein, human
keywords: Gleason score; prostate cancer; urotensin II receptor