title: Ivermectin 1% cream for rosacea.
abstract: The etiology of papulopustular rosacea (PPR) is not well understood yet appears to involve both the innate and adaptive immune response in addition to possible infestation with Demodex mites. Current treatments for PPR consist mainly of antibiotics. Ivermectin cream 1%, a new topical treatment for PPR, possesses both anti-inflammatory and anti-parasitic properties. After 12 weeks of treatment, subjects treated with ivermectin cream 1% had significantly greater reductions in PPR symptoms and enhanced diseaserelated quality of life improvements compared to subjects who received vehicle. Furthermore, PPR symptoms continued to improve with prolonged treatment (40 weeks). Ivermectin cream 1% offers a multi-pronged approach to combat the complex pathophysiology of rosacea.
authors.affiliation: Wayne State University, Detroit, MI, USA; Mediprobe Research Inc., London, ON, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Gupta
authors.affiliation: Mediprobe Research Inc., London, ON, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Daigle
authors.affiliation: Mediprobe Research Inc., London, ON, Canada; Department of Medicine, University of Toronto School of Medicine, Toronto, ON, Canada.
authors.forename: A K
authors.initials: AK
authors.lastname: Gupta
authors.affiliation: Henry Ford Medical Center, Department of Dermatology, Detroit, MI, USA.
authors.forename: L S
authors.initials: LS
authors.lastname: Gold
mesh_terms: D000287:Administration, Topical; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000977:Antiparasitic Agents / Q000008:administration & dosage*; D017326:Clinical Trials, Phase III as Topic; D003879:Dermatologic Agents / Q000627:therapeutic use; D003998:Dicarboxylic Acids / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D012393:Rosacea / Q000188:drug therapy*; D063465:Skin Cream
chemical_list: D000890:Anti-Infective Agents; D000977:Antiparasitic Agents; D003879:Dermatologic Agents; D003998:Dicarboxylic Acids; D008795:Metronidazole; D007559:Ivermectin; C010038:azelaic acid