title: Treatment of Lyme neuroborreliosis with plasmapheresis.
abstract: Lyme disease is a rare tick-borne multisystemic infection caused by Borrelia burgdorferi. Different neurological conditions were reported in the disease. In this article, we present a 15-year-old patient hospitalized with ataxia who was diagnosed with Lyme neuroborreliosis. Intravenous immunoglobulin and ceftriaxone treatment was applied to the patient for 4 weeks. However, ataxia did not recover, upper and lower muscle weakness developed, and deep tendon reflexes diminished during follow-up. The patient was diagnosed with Guillain-Barre syndrome arising from B. burgdorferi. Second dose of intravenous immunoglobulin treatment was started for 5 days but the patient didn't recover. Therefore administration of plasmapheresis was decided. All symptoms relieved following the plasmapheresis. The effect of plasmapheresis in pediatric neuroborreliosis has not been documented before. This study highlights that plasmapheresis could be a useful alternative for pediatric neuroborreliosis cases. J. Clin. Apheresis 31:476-478, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Department of Pediatric Neurology, Adana Numune Research and Training Hospital, Adana, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Çelik
authors.affiliation: Department of Pediatric Infection, Adana Numune Research and Training Hospital, Adana, Turkey. ucelik32@gmail.com.
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Çelik
authors.affiliation: Department of Pediatric Neurology, Adana Numune Research and Training Hospital, Adana, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kömür
authors.affiliation: Department of Pediatrics, Adana Numune Research and Training Hospital, Adana, Turkey.
authors.forename: Orkun
authors.initials: O
authors.lastname: Tolunay
authors.affiliation: Department of Pediatrics, Adana Numune Research and Training Hospital, Adana, Turkey.
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Dönmezer
authors.affiliation: Department of Pediatric Intensive Care Unit, Cukurova University Faculty of Medicine, Adana, Turkey.
authors.forename: Dinçer
authors.initials: D
authors.lastname: Yıldızdas
mesh_terms: D000293:Adolescent; D001259:Ataxia; D025065:Borrelia burgdorferi / Q000472:pathogenicity*; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage; D020852:Lyme Neuroborreliosis / Q000628:therapy*; D008297:Male; D010956:Plasmapheresis; D016879:Salvage Therapy / Q000379:methods; D016896:Treatment Outcome
chemical_list: D007136:Immunoglobulins
keywords: Guillain-Barre; Lyme; child; plasmapheresis