title: Polymorphism of IL37 gene as a protective factor for autoimmune thyroid disease.
abstract: Autoimmune thyroid disease (AITD) comprises Graves' disease (GD) and Hashimoto's thyroiditis (HT). IL37 has been recently proved to be a natural suppressor for innate immunity and acquired immunity. Therefore, this study was conducted to identify the association of IL37 genetic polymorphisms with AITD in Chinese Han population. Polymorphisms of rs3811046/rs3811047/rs2723176/rs272186 in the IL37 gene were assessed in a case-control study comprising 701 GD patients, 301 HT patients and 939 controls. Genetic variants were genotyped by multiplex polymerase chain reaction and ligase detection reaction. The frequencies of the minor allele A of rs2723176 and A of rs2723186 were significantly lower in the GD patients than in the controls (P=0.014, OR=0.774; P=0.014, OR=0.777). After gender stratification, the rs3811046 G allele and the rs3811047/rs2723186 A allele were both significantly associated with a decreased risk of GD in female patients (P=0.030, OR=0.777; P=0.023, OR=0.774; P=0.029, OR=0.761). However, none of the four single nucleotide polymorphisms of IL37 gene showed any significant association with HT. Moreover, haplotype analysis revealed the GCG haplotype conferred increased risk for GD as a whole and in female GD patients (OR=1.213; OR=1.320). The ACG haplotype was associated with an increased risk of HT as a whole (OR=1.567) and in male GD patients (OR=1.820). In contrast, the AAA haplotype showed a protective role for GD as a whole (OR=0.760) and in female GD patients (OR=0.765). Our study strongly supports that the IL37 gene variants are associated with the susceptibility to AITD.
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Yan
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Meng
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Song
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Qin
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Qiuming
authors.initials: Q
authors.lastname: Yao
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Liangfeng
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of EndocrinologyJinshan Hospital of Fudan University, Number 1508 Longhang Road, Jinshan District, Shanghai 201508, China zhangjinan@hotmail.com.
authors.forename: Jinan
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000483:Alleles; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D004843:Epistasis, Genetic; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006111:Graves Disease / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D050031:Hashimoto Disease / Q000235:genetics / Q000276:immunology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D013959:Thyroid Diseases / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
chemical_list: D001323:Autoantibodies; C508587:IL37 protein, human; D007375:Interleukin-1
keywords: Graves' disease (GD); Hashimoto's thyroiditis (HT); IL1F7; IL37; autoimmune thyroid diseases (AITDs); single nucleotide polymorphisms (SNPs)