title: GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 and AKT Signaling Pathways.
abstract: The general control of nucleotide synthesis 5 (GCN5), which is one kind of lysine acetyltransferases, regulates a number of cellular processes, such as cell proliferation, differentiation, cell cycle and DNA damage repair. However, its biological role in human glioma development remains elusive. In the present study, we firstly reported that GCN5 was frequently overexpressed in human glioma tissues and GCN5 was positively correlated with proliferation of cell nuclear antigen PCNA and matrix metallopeptidase MMP9. Meanwhile, down-regulation of GCN5 by siRNA interfering inhibited glioma cell proliferation and invasion. In addition, GCN5 knockdown reduced expression of p-STAT3, p-AKT, PCNA and MMP9 and increased the expression of p21 in glioma cells. In conclusion, GCN5 exhibited critical roles in glioma development by regulating cell proliferation and invasion, which suggested that GCN5 might be a potential molecular target for glioma treatment.
authors.affiliation: Department of Pathology, Affiliated Chenggong Hospital, Xiamen University, Xiamen 361000, China. liukun0309@163.com.|Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. liukun0309@163.com.
authors.forename: Kun
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Pathology, Affiliated Chenggong Hospital, Xiamen University, Xiamen 361000, China. bioods@163.com.|Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. bioods@163.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China. lanht@sina.com.
authors.forename: Haitao
authors.initials: H
authors.lastname: Lan
authors.affiliation: Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. lotionmian@163.com.
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology, Affiliated Chenggong Hospital, Xiamen University, Xiamen 361000, China. mpf1314@126.com.|Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. mpf1314@126.com.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Mou
authors.affiliation: Department of Pathology, Affiliated Chenggong Hospital, Xiamen University, Xiamen 361000, China. vivishao@foxmail.com.|Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. vivishao@foxmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Shao
authors.affiliation: Department of Pathology, Affiliated Chenggong Hospital, Xiamen University, Xiamen 361000, China. luckydan100@126.com.|Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. luckydan100@126.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Pathology, Affiliated Chenggong Hospital, Xiamen University, Xiamen 361000, China. yws_huoyun@126.com.|Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. yws_huoyun@126.com.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Pathology, Affiliated Chenggong Hospital, Xiamen University, Xiamen 361000, China. xmlinzhen@139.com.|Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. xmlinzhen@139.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Pathology, Affiliated Chenggong Hospital, Xiamen University, Xiamen 361000, China. linqingyuan2007@163.com.|Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. linqingyuan2007@163.com.
authors.forename: Qingyuan
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Pathology, Affiliated Chenggong Hospital, Xiamen University, Xiamen 361000, China. skysea_ji@sina.com.|Chinese People's Liberation Army No. 174 Clinical College, Anhui Medical University, Xiamen 361000, China. skysea_ji@sina.com.
authors.forename: Tianhai
authors.initials: T
authors.lastname: Ji
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002453:Cell Cycle / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D020868:Gene Silencing; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction; D050880:p300-CBP Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000099224:p300-CBP-Associated Factor
chemical_list: D020780:Matrix Metalloproteinase 9; D018809:Proliferating Cell Nuclear Antigen; D051057:Proto-Oncogene Proteins c-akt; D050796:STAT3 Transcription Factor; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor
keywords: GCN5; STAT3; cell invasion; cell proliferation