title: Tomosynthesis-guided vacuum-assisted breast biopsy: A feasibility study.
abstract: OBJECTIVE
  Evaluation of feasibility and clinical performance of a tomosynthesis-guided vacuum-assisted breast biopsy (TVAB) system compared to Stereotaxy (SVAB).
  
  
  METHODS
  All biopsies were performed on consecutive patients: 148 TVAB biopsies and 86 biopsies on different patients using SVAB. Evaluation criteria for each biopsy were technical feasibility, histopathology, procedure time, and complications.
  
  
  RESULTS
  All 148 TVAB biopsies were technically successful, and gained the targeted groups of microcalcifications (100 %). In 1 of 86 SVAB procedures, it was not possible to gain the targeted microcalcifications (1 %), in 3 of 86 the needle had to be adjusted (4 %). All TVAB biopsies were performed without clinically relevant complications. Distortions were biopsied exclusively by TVAB, mean size 0.9 cm, p < 0.0001. Of the 24 distortions, 13 were cancer, 11 Radial Scars/ CSL. The mean procedure time for TVAB was 15.4 minutes (range 7-28 min), for SVAB 23 minutes (range 11-46 min), p < 0.0001.
  
  
  CONCLUSIONS
  TVAB is able to biopsy small architectural distortions with high accuracy. TVAB is easily feasible and appears to have the same degree of clinical performance for diagnosing microcalcifications. The increased number of biopsied distortions by TVAB is presumably due to increased use of tomosynthesis and its diagnostic potential.
  
  
  CONCLUSIONS
  • TVAB is easily feasible. • TVAB is able to target architectural distortions with high accuracy. • TVAB diagnoses microcalcifications with the same clinical performance as SVAB.
authors.affiliation: Breast Centre Bern (Brustzentrum Bern), Division of Radiology & Nuclear Medicine, Klinik Engeried, Lindenhofgruppe, Riedweg 15, 3012 Bern, Bern, Switzerland. christian.waldherr@lindenhofgruppe.ch.
authors.forename: Christian
authors.initials: C
authors.lastname: Waldherr
authors.affiliation: Breast Centre Bern (Brustzentrum Bern), Division of Gynaecology & Surgical Oncology, Klinik Engeried, Lindenhofgruppe, Bern, Switzerland.
authors.forename: Gilles
authors.initials: G
authors.lastname: Berclaz
authors.affiliation: Institute of Pathology Länggasse, Division of Histopathology, Bern, Switzerland.
authors.forename: Hans Jörg
authors.initials: HJ
authors.lastname: Altermatt
authors.affiliation: Breast Centre Bern (Brustzentrum Bern), Division of Radiology & Nuclear Medicine, Klinik Engeried, Lindenhofgruppe, Riedweg 15, 3012 Bern, Bern, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Cerny
authors.affiliation: Breast Centre Bern (Brustzentrum Bern), Division of Radiology & Nuclear Medicine, Klinik Engeried, Lindenhofgruppe, Riedweg 15, 3012 Bern, Bern, Switzerland.
authors.forename: Patrik
authors.initials: P
authors.lastname: Keller
authors.affiliation: Breast Centre Bern (Brustzentrum Bern), Division of Gynaecology & Surgical Oncology, Klinik Engeried, Lindenhofgruppe, Bern, Switzerland.
authors.forename: Uwe
authors.initials: U
authors.lastname: Dietz
authors.affiliation: Breast Centre Bern (Brustzentrum Bern), Division of Oncology (Oncocare), Klinik Engeried, Lindenhofgruppe, Bern, Switzerland.
authors.forename: Katharina
authors.initials: K
authors.lastname: Buser
authors.affiliation: Breast Centre Bern (Brustzentrum Bern), Division of Oncology (Oncocare), Klinik Engeried, Lindenhofgruppe, Bern, Switzerland.
authors.forename: Michele
authors.initials: M
authors.lastname: Ciriolo
authors.affiliation: Breast Centre Bern (Brustzentrum Bern), Division of Radiology & Nuclear Medicine, Klinik Engeried, Lindenhofgruppe, Riedweg 15, 3012 Bern, Bern, Switzerland.
authors.forename: Martin Josef
authors.initials: MJ
authors.lastname: Sonnenschein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods; D001940:Breast / Q000000981:diagnostic imaging / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D018226:Fibroadenoma / Q000000981:diagnostic imaging / Q000473:pathology*; D005348:Fibrocystic Breast Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods; D021621:Imaging, Three-Dimensional; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D014618:Vacuum
keywords: Breast cancer; Diagnostic techniques and procedures; Image-guided biopsy; Mammography; Tomosynthesis