title: [Development of malignant tumors in patients with inflammatory bowel disease].
abstract: BACKGROUND
  The chronic inflammation of the intestinal mucosa, the extra-intestinal manifestations of the disease and the immunosuppressive treatment of inflammatory bowel disease may increase cancer risk.
  
  
  OBJECTIVE
  To report the demographic and clinical features of patients with IBD who developed a malignant tumor.
  
  
  METHODS
  Retrospective analysis of an IBD patient registry of a private clinic, diagnosed between 1976 and 2014.
  
  
  RESULTS
  437 subjects were included, aged 15-88 years (58% women). Seventy two percent of patients had ulcerative colitis. The median time of follow up was 6 years. Ten patients (2.3%) developed a malignant tumor. In four, the tumor could be related to IBD (two colorectal cancers, one cholangiocarcinoma and one chronic myeloid leukemia (CML)). Two of 45 patients treated with biological therapy developed a tumor (CML and hypernephroma). Three of 170 patients on immunosuppressive treatment developed tumors. Only one had a tumor possibly related with the use of azathioprine (non-melanoma skin cancer). In only two patients, the treatment was changed at the time of their cancer diagnosis, from immunosuppressive medications to mesalamine.
  
  
  CONCLUSIONS
  Only a small proportion of these patients with IBD developed a malignant tumor. The treatment of IBD has to be determined by the severity of the disease and not by the fear of developing a neoplasia. Following recommendations is fundamental to decrease the possibility of developing this complication.
authors.forename: Lital
authors.initials: L
authors.lastname: Meyer
authors.forename: Daniela
authors.initials: D
authors.lastname: Simian
authors.forename: Udo
authors.initials: U
authors.lastname: Kronberg
authors.forename: Camila
authors.initials: C
authors.lastname: Estay
authors.forename: Jaime
authors.initials: J
authors.lastname: Lubascher
authors.forename: Carolina
authors.initials: C
authors.lastname: Figueroa
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Quera
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001691:Biological Therapy / Q000009:adverse effects; D002677:Chile / Q000453:epidemiology; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000150:complications; D015179:Colorectal Neoplasms / Q000145:classification / Q000453:epidemiology / Q000209:etiology*; D003424:Crohn Disease / Q000150:complications; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents