title: Dermatoglyphic correlates of hippocampus volume: Evaluation of aberrant neurodevelopmental markers in antipsychotic-naïve schizophrenia.
abstract: Schizophrenia is a disorder of aberrant neurodevelopment is marked by abnormalities in brain structure and dermatoglyphic traits. However, the link between these two (i.e. dermatoglyphic parameters and brain structure) which share ectodermal origin and common developmental window has not been explored extensively. The current study examined dermatoglyphic correlates of hippocampal volume in antipsychotic-naïve schizophrenia patients in comparison with matched healthy controls. Ridge counts and asymmetry measures for palmar inter-digital areas (a-b, b-c, c-d) were obtained using high resolution digital scans of palms from 89 schizophrenia patients [M:F=48:41] and 48 healthy controls [M:F=30:18]. Brain scans were obtained for subset of subjects including 26 antipsychotic-naïve patients [M:F=13:13] and 29 healthy controls [M:F=19:10] using 3 T-MRI. Hippocampal volume and palmar ridge counts were measured by blinded raters with good inter-rater reliability using valid methods. Directional asymmetry (DA) of b-c and bilateral hippocampal volume were significantly lower in patients than controls. Significant positive correlation was found between DA and ridge count of b-c with bilateral anterior hippocampal volume. Study demonstrates the utility of dermatoglyphic markers in identifying structural changes in the brain which may form the basis for neurodevelopmental pathogenesis in schizophrenia.
authors.affiliation: InSTAR Program, Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, NIMHANS, Bangalore, India.
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Kalmady
authors.affiliation: InSTAR Program, Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, NIMHANS, Bangalore, India.
authors.forename: Venkataram
authors.initials: V
authors.lastname: Shivakumar
authors.affiliation: Translational Psychiatry Laboratory, Neurobiology Research Centre, NIMHANS, Bangalore, India.
authors.forename: S
authors.initials: S
authors.lastname: Gautham
authors.affiliation: InSTAR Program, Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, NIMHANS, Bangalore, India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Arasappa
authors.affiliation: Translational Psychiatry Laboratory, Neurobiology Research Centre, NIMHANS, Bangalore, India.
authors.forename: Dania A
authors.initials: DA
authors.lastname: Jose
authors.affiliation: InSTAR Program, Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, NIMHANS, Bangalore, India. Electronic address: venkat.nimhans@yahoo.com.
authors.forename: Ganesan
authors.initials: G
authors.lastname: Venkatasubramanian
authors.affiliation: InSTAR Program, Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, NIMHANS, Bangalore, India.
authors.forename: B N
authors.initials: BN
authors.lastname: Gangadhar
mesh_terms: D000328:Adult; D015415:Biomarkers; D003878:Dermatoglyphics; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D009929:Organ Size; D010641:Phenotype; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000235:genetics / Q000473:pathology*; D055815:Young Adult
chemical_list: D015415:Biomarkers