title: Growth hormone therapy in children with CKD after more than two decades of practice.
abstract: This review focuses on the evidence for the efficacy and safety of recombinant human growth hormone (rhGH) therapy in children with all stages of chronic kidney disease (CKD) and at all ages. It describes the improving height prognosis for our patients both with and without rhGH; explains the underlying hormonal abnormalities that provide the rationale for rhGH use in CKD and the endocrine changes that accompany treatment; and views on who warrants treatment, with what dose, and how long for.
authors.affiliation: Gt Ormond St Hospital for Children NHS Foundation Trust, London, WC1N3JH, UK. lesley.rees@gosh.nhs.uk.
authors.forename: Lesley
authors.initials: L
authors.lastname: Rees
mesh_terms: D001827:Body Height; D002648:Child; D006130:Growth Disorders / Q000209:etiology*; D013006:Growth Hormone / Q000627:therapeutic use*; D019382:Human Growth Hormone; D006801:Humans; D011994:Recombinant Proteins; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000188:drug therapy*
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone; D013006:Growth Hormone
keywords: Final height; Growth; Growth hormone