title: Evidence of slow Debye-like relaxation in the anti-inflammatory agent etoricoxib.
abstract: The origin of Debye-like relaxation in some hydrogen-bonded liquids is a matter of hot debate over the past decade. While a relatively clear picture of the issue has been established for monohydroxy alcohols, the Debye-type dynamics in other glass-forming systems still remains a not fully understood phenomenon. In this paper we present the results of dielectric measurements performed in the frequency interval 10(-1) to 10(9)Hz, both in the supercooled and normal liquid state of etoricoxib anti-inflammatory agent. Our investigations reveal the presence of slow Debye-like relaxation with features similar to that found for another active pharmaceutical ingredient, ibuprofen. Our results provide a fresh insight into the molecular nature of Debye-type relaxation in H-bonded pharmaceutically relevant materials and thus may stimulate the academic community for further discussion concerning the molecular dynamics of hydrogen-bonded fluids in general.
authors.affiliation: Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland.|Silesian Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1a, 41-500 Chorzow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Rams-Baron
authors.affiliation: Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland.|Silesian Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1a, 41-500 Chorzow, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Wojnarowska
authors.affiliation: Institute of Material Sciences, University of Silesia, 75 Pułku Piechoty 1a, 41-500 Chorzow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Dulski
authors.affiliation: Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland.|Silesian Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1a, 41-500 Chorzow, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Ratuszna
authors.affiliation: Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland.|Silesian Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1a, 41-500 Chorzow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Paluch
mesh_terms: D003198:Computer Simulation; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D058266:Dielectric Spectroscopy; D000077613:Etoricoxib; D006860:Hydrogen Bonding; D007052:Ibuprofen / Q000737:chemistry / Q000494:pharmacology; D008956:Models, Chemical; D011522:Protons; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology; D013450:Sulfones / Q000737:chemistry* / Q000494:pharmacology; D013696:Temperature
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D011522:Protons; D011725:Pyridines; D013450:Sulfones; D007052:Ibuprofen; D000077613:Etoricoxib