title: Multifunctional copolymer coating of polyethylene glycol, glycidyl methacrylate, and REDV to enhance the selectivity of endothelial cells.
abstract: Multifunctional polymer coatings have potential applications in biomaterials. These coatings possess reactive functional groups for the immobilization of specific biological factors that can influence cellular behavior. These coatings also display low nonspecific protein adsorption. In this study, we prepared a multifunctional polymer coating through the deposition of random copolymers of poly(ethylene glycol) methacrylate (PEGMA) and glycidyl methacrylate (GMA) to prevent nonspecific attachment and enable the covalence of Arg-Glu-Asp-Val (REDV) peptide with endothelial cells (ECs) selectivity. Coatings were characterized by X-ray photoelectron spectroscopy (XPS). The adhesion and proliferation of ECs and smooth muscle cells (SMCs) onto the REDV-modified surface were investigated to understand the synergistic action of antifouling PEG and EC selective REDV peptide conjugated GMA. The copolymers containing GMA and PEG groups are very useful as a multifunctional coating material with anti-fouling and ECs specific adhesion for implant materials surface modification.
authors.affiliation: a Department of Chemistry and Chemical Engineering , Huanghuai University , Zhumadian 463000 , China.|b College of Chemistry and Chemical Engineering , Anhui University , Hefei 230601 , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wei
authors.affiliation: a Department of Chemistry and Chemical Engineering , Huanghuai University , Zhumadian 463000 , China.
authors.forename: Jingxun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Department of Chemistry and Chemical Engineering , Huanghuai University , Zhumadian 463000 , China.
authors.forename: Haolie
authors.initials: H
authors.lastname: Li
authors.affiliation: a Department of Chemistry and Chemical Engineering , Huanghuai University , Zhumadian 463000 , China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: b College of Chemistry and Chemical Engineering , Anhui University , Hefei 230601 , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Bi
mesh_terms: D057219:Biofouling / Q000517:prevention & control; D002448:Cell Adhesion; D049109:Cell Proliferation; D002470:Cell Survival; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000502:physiology*; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D032389:Myocytes, Smooth Muscle / Q000502:physiology; D009842:Oligopeptides / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization; D013499:Surface Properties; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D004852:Epoxy Compounds; D008689:Methacrylates; D009842:Oligopeptides; C000610191:arginyl-glutamyl-aspartyl-valine; D011092:Polyethylene Glycols; C007870:glycidyl methacrylate
keywords: ECs selectivity; GMA; PEGMA; anti-fouling; multifunctional coating