title: Expression of IL-17A, E, and F and their receptors in human prostatic cancer: Comparison with benign prostatic hyperplasia.
abstract: BACKGROUND
  Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are the most common urological diseases in elderly men. Although studies suggest the cytokine family might be associated with BPH and PCa, there has been no systematic comparisons of expression of IL-17A, E, F and their receptors, infiltration of inflammatory cells, and changes in structural cells in PCa and BPH.
  
  
  METHODS
  Immunohistochemistry was employed to evaluate immunoreactivity for IL-17A, E, F and their receptors IL-17RA, IL-17BR, and IL-17CR, infiltration of inflammatory cells, and changes in structural cells including endothelial cells, fibroblasts, and smooth muscle cells in prostate tissues from subjects with PCa or BPH as well as controls.
  
  
  RESULTS
  Immunostaining showed that expression of immunoreactivity for IL-17A, IL-17RA, IL-17E, and IL-17F was significantly elevated in prostatic tissue from BPH and PCa compared with that in controls, which was accompanied by increased numbers of infiltrating inflammatory cells and CD31(+) blood vessels. Compared with BPH, PCa was characterized by reduced immunoreactivity for IL-17BR and reduced numbers of CD68(+) macrophages, fibroblasts, and smooth muscle cells, although there was a trend for these changes to correlate with disease severity in both PCa and BPH.
  
  
  CONCLUSIONS
  Our data are compatible with hypothesis that IL-17A acting through IL-17RA, but not IL-17CR contribute to the pathogenesis of BPH and PCa. In contrast, IL-17E interacting with the IL-17BR might have an anti-tumor effect.
authors.affiliation: Clinical Immunology Research Centre, Beihua University, Jilin City, Jilin, China.
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Clinical Immunology Research Centre, Beihua University, Jilin City, Jilin, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Clinical Immunology Research Centre, Beihua University, Jilin City, Jilin, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Sun
authors.affiliation: Clinical Immunology Research Centre, Beihua University, Jilin City, Jilin, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Clinical Immunology Research Centre, Beihua University, Jilin City, Jilin, China.
authors.forename: Zhenjiang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Clinical Immunology Research Centre, Beihua University, Jilin City, Jilin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Clinical Immunology Research Centre, Beihua University, Jilin City, Jilin, China.
authors.forename: Huiming
authors.initials: H
authors.lastname: Han
authors.affiliation: Clinical Immunology Research Centre, Beihua University, Jilin City, Jilin, China.
authors.forename: Weigao
authors.initials: W
authors.lastname: Shen
authors.affiliation: Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Corrigan
authors.affiliation: Clinical Immunology Research Centre, Beihua University, Jilin City, Jilin, China.|Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000378:metabolism / Q000473:pathology; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D053722:Receptors, Interleukin-17 / Q000378:metabolism*; D055815:Young Adult
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: IL-17 cytokine family; benign prostatic hyperplasia; inflammatory cell; prostatic carcinoma; structural cell