title: Modulation of epithelial-to-mesenchymal cancerous transition by natural products.
abstract: Metastasis is mainly responsible for poor prognosis of cancer, and epithelial-to-mesenchymal transition (EMT) is a significant process often activated during cancer invasion and metastasis. Therefore EMT could be an effective target of chemotherapy to inhibit cancer metastasis and improve prognosis. Considering that many chemotherapeutics are plant-based, we reviewed recent reports about natural products extracted from plants and cancer EMT prevention.
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China; Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China. Electronic address: lmd@cpu.edu.cn.
authors.forename: Maode
authors.initials: M
authors.lastname: Lai
mesh_terms: D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D064209:Phytochemicals / Q000494:pharmacology*; D028321:Plant Preparations / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D064209:Phytochemicals; D028321:Plant Preparations
keywords: Carcinoma; Chemotherapy; Epithelial-to-mesenchymal transition; Metastasis; Natural products; Pathway signaling