title: Compaction behavior and deformation mechanism of directly compressible textured mannitol in a rotary tablet press simulator.
abstract: Textured mannitol powder is widely used as a pharmaceutical excipient for tablet compaction. In order to choose the right tableting parameters, it is necessary to understand its mechanical behavior during deformation under industrial tableting conditions. The aim of this study was to evaluate the mechanical behavior during deformation of a textured mannitol using a rotary tablet press simulator. Mean yield pressure (Py) obtained by Heckel modeling, Walker coefficients (W) and Stress Rate Sensitivity (SRS) were compared to reference excipients, known for either their plastic (microcrystalline cellulose) or fragmentary (lactose and dibasic calcium phosphate) deformation behavior. Py, W and SRS values showed that the studied textured mannitol has a fragmentary deformation mechanism. Furthermore, this mechanical behavior was not sensitive to lubrication, which is characteristic of fragmentary excipients.
authors.affiliation: Institut Charles Gerhardt UMR5253 Equipe MACS, UFR Sciences Pharmaceutiques et Biologiques - Université de Montpellier, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Tarlier
authors.affiliation: Institut Charles Gerhardt UMR5253 Equipe MACS, UFR Sciences Pharmaceutiques et Biologiques - Université de Montpellier, France.
authors.forename: Ian
authors.initials: I
authors.lastname: Soulairol
authors.affiliation: Institut Charles Gerhardt UMR5253 Equipe MACS, UFR Sciences Pharmaceutiques et Biologiques - Université de Montpellier, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Bataille
authors.affiliation: Institut Charles Gerhardt UMR5253 Equipe MACS, UFR Sciences Pharmaceutiques et Biologiques - Université de Montpellier, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Baylac
authors.affiliation: CNRS CPBS-UMR 5236, UFR Sciences Pharmaceutiques et Biologiques-Université de Montpellier, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Ravel
authors.affiliation: Institut Charles Gerhardt UMR5253 Equipe MACS, UFR Sciences Pharmaceutiques et Biologiques - Université de Montpellier, France.
authors.forename: Isaac
authors.initials: I
authors.lastname: Nofrerias
authors.affiliation: Food, Nutrition and Health Application Development Center-Roquette Freres, Lestrem, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lefèvre
authors.affiliation: Institut Charles Gerhardt UMR5253 Equipe MACS, UFR Sciences Pharmaceutiques et Biologiques - Université de Montpellier, France.
authors.forename: Tahmer
authors.initials: T
authors.lastname: Sharkawi
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D008353:Mannitol / Q000737:chemistry*; D055595:Mechanical Phenomena; D011208:Powders / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D002130:Calcium Phosphates; D011208:Powders; D013607:Tablets; D008353:Mannitol; D002482:Cellulose; D007785:Lactose; C485829:calcium phosphate, dibasic, anhydrous; C109691:microcrystalline cellulose
keywords: Fragmentary; Mean yield pressure; Press simulator; Textured mannitol; lubrication