title: The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome.
abstract: BACKGROUND
  Limited data are available indicating the effects of coenzyme Q10 (CoQ10) supplementation on metabolic status of patients with metabolic syndrome (MetS).
  
  
  OBJECTIVE
  The present study was conducted to determine the effects of CoQ10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress among patients with MetS.
  
  
  METHODS
  This randomized, double-blind, placebo-controlled trial was performed among 60 overweight or obese and type 2 diabetes mellitus patients with coronary heart disease aged 40-85 years old. Participants were randomly allocated into two groups. Group A (n = 30) received 100 mg CoQ10 supplements and group B (n = 30) received placebo for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8-week intervention to quantify glucose homeostasis parameters, lipid profiles and biomarkers of inflammation and oxidative stress.
  
  
  RESULTS
  Compared with the placebo, CoQ10 supplementation resulted in a significant reduction in serum insulin levels (-2.1 ± 7.1 vs. +4.1 ± 7.8 µIU/mL, P = 0.002) and homeostasis model of assessment-insulin resistance (-0.7 ± 2.1 vs. +1.0 ± 2.0, P = 0.002) and homeostatic model assessment-beta cell function (-5.9 ± 22.2 vs. +15.9 ± 34.0, P = 0.005). In addition, patients who received CoQ10 supplements had a significant increase in plasma total antioxidant capacity (TAC) concentrations (+26.0 ± 105.0 vs. -162.2 ± 361.8 mmol/L, P = 0.008) compared with the placebo group. However, after adjustment for the baseline levels, age and baseline BMI, the effect on TAC levels (P = 0.08) disappeared. Additionally, compared with the placebo group, a significant positive trends in plasma glutathione (P = 0.06) and a significant reduction in malondialdehyde (P = 0.08) were seen among patients who received CoQ10 supplement. We did not observe any significant changes in fasting plasma glucose, lipid concentrations and inflammatory markers.
  
  
  CONCLUSIONS
  Overall, daily intake of 100 mg CoQ10 supplements among patients with MetS for 8 weeks had beneficial effects on serum insulin levels, HOMA-IR, HOMA-B and plasma TAC concentrations.
  
  
  BACKGROUND
  www.irct.ir : IRCT201502245623N35.
authors.affiliation: Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Raygan
authors.affiliation: Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Rezavandi
authors.affiliation: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Sahar
authors.initials: S
authors.lastname: Dadkhah Tehrani
authors.affiliation: Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Farrokhian
authors.affiliation: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. asemi_r@yahoo.com.
authors.forename: Zatollah
authors.initials: Z
authors.lastname: Asemi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D002149:Energy Intake; D005978:Glutathione / Q000097:blood; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D009765:Obesity / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014451:Ubiquinone; D009569:Nitric Oxide; D008315:Malondialdehyde; D002097:C-Reactive Protein; C024989:coenzyme Q10; D005978:Glutathione
keywords: Coenzyme Q10; Coronary heart disease; Metabolic syndrome; Supplementation; Type 2 diabetes mellitus