title: Serum protein adsorption and excretion pathways of metal nanoparticles.
abstract: While the synthesis of metal nanoparticles (NPs) with fascinating optical and electronic properties have progressed dramatically and their potential biomedical applications were also well demonstrated in the past decade, translation of metal NPs into the clinical practice still remains a challenge due to their severe accumulation in the body. Herein, we give a brief review on size-dependent material properties of metal NPs and their potential biomedical applications, followed by a summary of how structural parameters such as size, shape and charge influence their interactions with serum protein adsorption, cellular uptake and excretion pathways. Finally, the future challenges in minimizing serum protein adsorption and expediting clinical translation of metal NPs were also discussed.
authors.affiliation: Department of Chemistry, The University of Texas at Dallas, Richardson, TX 75080, USA.
authors.forename: Rodrigo D
authors.initials: RD
authors.lastname: Vinluan
authors.affiliation: Department of Chemistry, The University of Texas at Dallas, Richardson, TX 75080, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000327:Adsorption; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008099:Liver; D053768:Metal Nanoparticles / Q000737:chemistry*; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy; D010316:Particle Size; D020349:Surface Plasmon Resonance; D013499:Surface Properties
chemical_list: D001798:Blood Proteins
keywords: biodistribution; clearance; excretion; metal nanoparticles; nanoparticle; protein adsorption; protein corona