title: Synthesis and anticancer activities of novel 8-azapurine carbocyclic nucleoside hydrazones.
abstract: A series of novel 8-azapurine carbocyclic nucleoside hydrazones were synthesized through a useful procedure starting from amino alcohol and pyrimido dichloride. All the products were characterized by (1)H NMR, (13)C NMR and HRMS spectral analysis and the stereochemical structure of key intermediate was also confirmed by a single crystal X-ray diffraction crystallographic analysis. Moreover, the anticancer activities were evaluated in vitro against human liver cancer Huh-7 cell line and human breast cancer A549 cell line.
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, PR China.
authors.forename: Yeming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, PR China. Electronic address: hongyan@bjut.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
authors.affiliation: Beijing Medking Pharmaceutical Technology Co. Ltd, Hongxianghong Business Incubator Block C, Room 301, Changping District, Beijing 102209, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: Beijing Medking Pharmaceutical Technology Co. Ltd, Hongxianghong Business Incubator Block C, Room 301, Changping District, Beijing 102209, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Lu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009705:Nucleosides; D011687:Purines
keywords: 8-Azapurine; Anticancer; Carbocyclic nucleoside; Hydrazones