title: Acute generalized exanthematous pustulosis x Von Zumbusch's pustular psoriasis: a diagnostic challenge in a psoriatic patient.
abstract: Severe cutaneous drug reactions include a wide spectrum of clinical manifestations ranging from mild morbilliform cutaneous rash, to severe forms of hypersensitivity. Special attention is given in this report to the acute generalized exanthematous pustulosis (AGEP), induced in 90% of cases by the use of systemic drugs, especially aminopenicillins and macrolides. The incidence of the disease is low, 1-5 cases per million patients / year. The main differential diagnosis is Von Zumbusch's Pustular Psoriasis. The prognosis is generally good and the disease self limited, after withdrawal of the triggering drug. In this report the authors describe a case of AGEP, triggered by ceftriaxone in a patient with psoriasis vulgaris.
authors.affiliation: Complexo Hospitalar Padre Bento de Guarulhos, Guarulhos, SP, BR.
authors.forename: Aline Soares de
authors.initials: AS
authors.lastname: Sousa
authors.affiliation: Complexo Hospitalar Padre Bento de Guarulhos, Guarulhos, SP, BR.
authors.forename: Osório Alves Corrêa de Castro
authors.initials: OA
authors.lastname: Lara
authors.affiliation: Instituto de Dermatologia Prof. Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: Francine
authors.initials: F
authors.lastname: Papaiordanou
authors.affiliation: Complexo Hospitalar Padre Bento de Guarulhos, Guarulhos, SP, BR.
authors.forename: Gláucia Silva Simioni
authors.initials: GS
authors.lastname: Marchioro
authors.affiliation: Complexo Hospitalar Padre Bento de Guarulhos, Guarulhos, SP, BR.
authors.forename: Antonio José
authors.initials: AJ
authors.lastname: Tebcherani
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000209:etiology* / Q000473:pathology*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001706:Biopsy; D002443:Ceftriaxone / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000139:chemically induced / Q000473:pathology*
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone