title: The efficacy of intrauterine injection of human chorionic gonadotropin before embryo transfer in assisted reproductive cycles: Meta-analysis.
abstract: OBJECTIVE
  A systematic review and meta-analysis to evaluate the effect of human chorionic gonadotropin (hCG) intrauterine injection before embryo transfer on the outcome of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Searches of PubMed®, EMBASE®, EBSCO, Web of Science®, SCOPUS® and Cochrane Central Register of Controlled Trials were conducted to retrieve relevant randomized controlled trials (RCTs). Data were extracted and analysed.
  
  
  RESULTS
  The meta-analysis included five RCTs (hCG group n = 680; control group n = 707). Intrauterine hCG injection significantly increased rates of biochemical, clinical and ongoing pregnancy compared with controls. There were no between-group differences in implantation or miscarriage rates.
  
  
  CONCLUSIONS
  Women undergoing IVF/ICSI may benefit from intrauterine hCG injection before embryo transfer.
authors.affiliation: Reproductive Medicine Centre, Department of Obstetrics and Gynaecology, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, China yehongtgu@126.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Ye
authors.affiliation: Reproductive Medicine Centre, Department of Obstetrics and Gynaecology, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: Reproductive Medicine Centre, Department of Obstetrics and Gynaecology, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, China.
authors.forename: Wencong
authors.initials: W
authors.lastname: He
authors.affiliation: Reproductive Medicine Centre, Department of Obstetrics and Gynaecology, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Reproductive Medicine Centre, Department of Obstetrics and Gynaecology, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, China.
authors.forename: Caihong
authors.initials: C
authors.lastname: Li
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000494:pharmacology*; D004333:Drug Administration Routes; D010064:Embryo Implantation / Q000187:drug effects; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D006063:Chorionic Gonadotropin
keywords: Intrauterine injection; embryo transfer; endometrial infusion; hCG; human chorionic gonadotropin; intracytoplasmic sperm injection; in vitro fertilization; meta-analysis