title: Nano-Aggregates of Doxorubicin-Conjugated Methoxy Poly(ethylene glycol)-b-Carboxymethyl Dextran Copolymer.
abstract: Block copolymer composed of carboxymethyl dextran (CMDex) and methoxy poly(ethylene glycol) (MPEG) (abbreviated as CMDexPEG) was synthesized and doxorubicin (DOX) was conjugated with carboxyl groups of CMDexPEG. DOX-conjugated CMDexPEG block copolymer formed nanoparticles in water with sizes less than 100 nm. DOX-conjugated nanoparticles enhanced DOX delivery to the DOX-resistant CT26 cells and showed higher anticancer activity in vitro. DOX-conjugated nanoparticles inhibited growth of CT26 solid tumor at tumor-bearing mouse model study. In near infrared (NIR)-dye study, nanoparticles were retained in the tumor tissues for a longer period.
authors.forename: Sang Joon
authors.initials: SJ
authors.lastname: Lee
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Kang
authors.forename: Jong-Suk
authors.initials: JS
authors.lastname: Oh
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Jeong
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Park
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Lee
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003911:Dextrans / Q000737:chemistry*; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D058726:Nanoconjugates / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D003911:Dextrans; D053769:Nanocapsules; D058726:Nanoconjugates; D011092:Polyethylene Glycols; D004317:Doxorubicin; C014392:carboxymethyl dextran