title: Improved gene prediction by principal component analysis based autoregressive Yule-Walker method.
abstract: Spectral analysis using Fourier techniques is popular with gene prediction because of its simplicity. Model-based autoregressive (AR) spectral estimation gives better resolution even for small DNA segments but selection of appropriate model order is a critical issue. In this article a technique has been proposed where Yule-Walker autoregressive (YW-AR) process is combined with principal component analysis (PCA) for reduction in dimensionality. The spectral peaks of DNA signal are used to detect protein-coding regions based on the 1/3 frequency component. Here optimal model order selection is no more critical as noise is removed by PCA prior to power spectral density (PSD) estimation. Eigenvalue-ratio is used to find the threshold between signal and noise subspaces for data reduction. Superiority of proposed method over fast Fourier Transform (FFT) method and autoregressive method combined with wavelet packet transform (WPT) is established with the help of receiver operating characteristics (ROC) and discrimination measure (DM) respectively.
authors.affiliation: Institute of Radio Physics and Electronics, University of Calcutta, 92, APC Road, Kolkata 700009, India.
authors.forename: Manidipa
authors.initials: M
authors.lastname: Roy
authors.affiliation: Institute of Radio Physics and Electronics, University of Calcutta, 92, APC Road, Kolkata 700009, India. Electronic address: barmanmandal@gmail.com.
authors.forename: Soma
authors.initials: S
authors.lastname: Barman
mesh_terms: D000465:Algorithms; D000818:Animals; D004247:DNA / Q000032:analysis*; D005583:Fourier Analysis; D006801:Humans; D008957:Models, Genetic; D025341:Principal Component Analysis / Q000379:methods*; D012372:ROC Curve
chemical_list: D004247:DNA
keywords: Eigenvalue-ratio; Principal component analysis; Spectral analysis; Wavelet packet transform