title: Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis.
abstract: Thymine DNA glycosylase (TDG) is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic development and carcinogenesis. This review discusses the molecular function of TDG in human cancers and the previously unrecognized value of TDG as a potential target for drug therapy.
authors.affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY 40536-0509, USA.
authors.forename: Xuehe
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY 40536-0509, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Watt
authors.affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY 40536-0509, USA chunming.liu@uky.edu.
authors.forename: Chunming
authors.initials: C
authors.lastname: Liu
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D004247:DNA / Q000235:genetics*; D019175:DNA Methylation; D004260:DNA Repair; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D013379:Substrate Specificity; D044502:Thymine DNA Glycosylase / Q000378:metabolism*
chemical_list: D004247:DNA; D044502:Thymine DNA Glycosylase
keywords: DNA demethylation; DNA repair; TDG; cancer; transcription