title: Positivity and incidence of human papillomavirus in women attending gynecological department of a major comprehensive hospital in Kunming, China 2012-2014.
abstract: HPV DNA testing is receiving increasing popularity in cervical cancer screening. There is a lack of universal guidelines on HPV testing. Our study aimed to assess age-specific and year-on-year trend of HPV positivity and incidence and HPV retesting among 26,457 individual women attending the gynecological department at the First People's Hospital of Yunnan Province (FPHY) who had an HPV testing between January 1, 2012 and December 31, 2014. HPV 16, HPV 52, and cp8304 ranked among top 5 with regard to positivity in each year and overall incidence. The positivity of various HPV types peaked among women aged 15-19 years, then sharply decreased with age, stabilized among women aged 25-49 years and then surged again among women aged 50 years and older. The positivity of high-risk (HR) HPV types, including HPV 16, 18, 31, 33, 56 and 58, were on the rise during the time period (P < 0.05 for all). HR HPV types tended to be more likely to persist than LR HPV types (P < 0.05). Additionally, the incidence rate for any HR HPV type was also significantly higher than that for any LR HPV type (42.8 vs. 12.6 per 100 person-years, P < 0.001). The majority (57.3-77.5%) of women detected with HR HPV types did not retest within 12 months. Clinical guidelines on HPV DNA testing are needed and education, and counseling about HPV infection and its implications for women detected with HPV at clinical settings, are warranted.
authors.affiliation: Kirby Institute, University of New South Wales, New South Wales, Australia.
authors.forename: Huachun
authors.initials: H
authors.lastname: Zou
authors.affiliation: Department of Clinical Laboratories, The First People's Hospital of Yunnan, Province, Kunming, Yunnan, China.|Department of Clinical Laboratories, The Kunhua Affiliated Hospital, Kunming, University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Clinical Laboratories, The First People's Hospital of Yunnan, Province, Kunming, Yunnan, China.|Department of Clinical Laboratories, The Kunhua Affiliated Hospital, Kunming, University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Guiqian
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Yunan Kunming Blood Center, Kuming, Yunnan, China.
authors.forename: Yuanquan
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Meng
authors.affiliation: Huainan First People's Hospital, Huainan, Anhui, China.
authors.forename: Tieniu
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Clinical Laboratories, The First People's Hospital of Yunnan, Province, Kunming, Yunnan, China.|Department of Clinical Laboratories, The Kunhua Affiliated Hospital, Kunming, University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Zhuxian
authors.initials: Z
authors.lastname: Ping
authors.affiliation: Department of Clinical Laboratories, The First People's Hospital of Yunnan, Province, Kunming, Yunnan, China.|Department of Clinical Laboratories, The Kunhua Affiliated Hospital, Kunming, University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Clinical Laboratories, The First People's Hospital of Yunnan, Province, Kunming, Yunnan, China.|Department of Clinical Laboratories, The Kunhua Affiliated Hospital, Kunming, University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000328:Adult; D000367:Age Factors; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D055088:Early Detection of Cancer; D005260:Female; D005838:Genotype; D006761:Hospitals; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D055815:Young Adult
keywords: China; human papillomavirus (HPV); testing; women