title: Electrofocusing-enhanced localized surface plasmon resonance biosensors.
abstract: Localized surface plasmon resonance (LSPR) biosensors typically suffer from diffusion limited mass transport and nonspecific adsorption upon detection of biomolecules in real biofluids. We employ here a peptide-modified plasmonic gold nanohole (AuNH) array for real-time detection of human troponin I (cTnI). Applying a negative electric bias on the AuNH sensor chip enables us to attract and concentrate cTnI at the sensor surface, while repelling other proteins thus decreasing interferences due to nonspecific adsorption.
authors.affiliation: Centre for Biomimetic Sensor Science, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553. bliedberg@ntu.edu.sg yiwang@ntu.edu.sg.
authors.forename: Jinling
authors.initials: J
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Ten It
authors.initials: TI
authors.lastname: Wong
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhou
authors.forename: Bo
authors.initials: B
authors.lastname: Liedberg
mesh_terms: D000818:Animals; D006046:Gold / Q000737:chemistry*; D006801:Humans; D058608:Nanopores; D011817:Rabbits; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods*; D019210:Troponin I / Q000032:analysis*
chemical_list: D019210:Troponin I; D006046:Gold