title: Ruthenium Catalyzed Selective α- and α,β-Deuteration of Alcohols Using D2O.
abstract: Highly selective ruthenium catalyzed α-deuteration of primary alcohols and α,β-deuteration of secondary alcohols are achieved using deuterium oxide (D2O) as a source of deuterium and reaction solvent. Minimal loading of catalyst (Ru-macho), base (KO(t)Bu), and low temperature heating provided efficient selective deuteration of alcohols making the process practically attractive and environmentally benign. Mechanistic studies indicate the D-O(D/R) bond activations by metal-ligand cooperation and intermediacy of carbonyl compounds resulting from dehydrogenation of alcohols.
authors.affiliation: School of Chemical Sciences, National Institute of Science Education and Research (NISER) , Bhubaneswar-751 005, India.
authors.forename: Basujit
authors.initials: B
authors.lastname: Chatterjee
authors.affiliation: School of Chemical Sciences, National Institute of Science Education and Research (NISER) , Bhubaneswar-751 005, India.
authors.forename: Chidambaram
authors.initials: C
authors.lastname: Gunanathan