title: DNA repair gene ERCC1 polymorphisms and glioma susceptibility among Chinese population: a meta-analysis.
abstract: BACKGROUND
  Excision repair cross complementation group 1 (ERCC1) has been shown to be involved in the progression of glioma susceptibility. However, the results remain conflict. The aim of this study was to systematically review and evaluate the role of ERCC1 C118T and C8092A polymorphisms in glioma risk among Chinese population.
  
  
  METHODS
  Related case-control studies were searched in online electronic databases. Odds ratio (OR) with its 95% confidence interval (CI) were employed to calculate the extracted data.
  
  
  RESULTS
  Total seven articles were retrieved, including 4426 subjects (1926 were glioma patients and 2500 were matched controls). No significant heterogeneity was found between studies (I(2)=0%, P>0.01). Our results demonstrated that A allele and AA genotype of ERCC1 C8092A polymorphism have a positive association with increasing the risk of glioma in the fixed-effect model (A vs. C: OR=1.13, 95% CI=1.02-1.25, P=0.02; AA vs. CC: OR=1.29, 95% CI=1.04-1.61, P=0.02; AA vs. CA+CC: OR=1.25, 95% CI=1.01-1.55, P=0.04). However, no significant relationship was found between C118T variant and glioma susceptibility.
  
  
  CONCLUSIONS
  Our results indicated that ERCC1 C8092A, not C118T polymorphism might be a biomarker for patients with glioma among Chinese population. Future studies with more ethnicities are needed to explore the precise association.
authors.affiliation: Department of Pediatrics, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital Hangzhou 301103, Zhejiang, P. R. China.
authors.forename: Chunming
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of psychiatry, Tongde Hospital of Zhejiang Province Hangzhou 301103, Zhejiang, P. R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Shen
authors.affiliation: Department of Pediatrics, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital Hangzhou 301103, Zhejiang, P. R. China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Du
authors.affiliation: Nanjing First Hospital, Nanjing Medical University Nanjing 210029, Jiangsu, P. R. China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu, P. R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Pediatrics, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital Hangzhou 301103, Zhejiang, P. R. China.
authors.forename: Zhanli
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital Hangzhou 301103, Zhejiang, P. R. China.
authors.forename: Xianmei
authors.initials: X
authors.lastname: Huang
keywords: DNA repair gene; ERCC1; Glioma; meta-analysis; polymorphism