title: Autologous Platelet Gel Improves Bone Reconstruction of Large Defects in Patients with Bone Giant Cell Tumors.
abstract: OBJECTIVE
  Giant cell tumors are mostly benign but locally aggressive tumors. The excision of bone tumors can result in large defects, therefore bone reconstruction is still one the most demanding procedures in orthopedic surgery. Our study addresses the opportunity for improving surgical outcome by employing β-tricalcium phosphate (β-TCP) with platelet-rich plasma (PRP) at the surgical site.
  
  
  METHODS
  We included 16 patients with giant cell tumors. After adjuvant therapy, the cavity was reconstructed with β-TCP, bone graft material (ActifuserR Granules Baxter) and platelet gel application.
  
  
  RESULTS
  Our explorative analysis suggests a positive effect of PRP on surgical outcome in patients with giant cell tumors treated with curettage.
  
  
  CONCLUSIONS
  Use of platelet gel as an adjuvant significantly reduces the time required for bone healing following intralesional treatment of benign giant cell tumors, and achieves good functional results without promoting local recurrence.
authors.affiliation: Transfusion Service, Department of Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy g.loquercio@istitutotumori.na.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Loquercio
authors.affiliation: Transfusion Service, Department of Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: DI Costanzo
authors.affiliation: Division of Skeletal Muscle Oncology Surgery, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Fazioli
authors.affiliation: Division of Skeletal Muscle Oncology Surgery, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Gallo
authors.affiliation: Division of Pathology, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy.
authors.forename: Annarosaria
authors.initials: A
authors.lastname: DE Chiara
authors.affiliation: Transfusion Service, Department of Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Iervolino
authors.affiliation: Transfusion Service, Department of Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Azzaro
authors.affiliation: Transfusion Service, Department of Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy.
authors.forename: Arnolfo
authors.initials: A
authors.lastname: Petruzziello
authors.affiliation: Transfusion Service, Department of Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Mattiello
authors.affiliation: Transfusion Service, Department of Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute G. Pascale Foundation, IRCCS, Naples, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Cacciapuoti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001804:Blood Transfusion, Autologous; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D003475:Curettage; D005260:Female; D005500:Follow-Up Studies; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D017713:Platelet Transfusion / Q000379:methods; D019651:Plastic Surgery Procedures; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
keywords: Giant cell tumor of bone; curettage; growth factors; loss of substance; platelet-rich plasma; regenerative medicine