title: Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults.
abstract: Aging-induced arterial stiffening is reduced by aerobic exercise training, and elevated production of nitric oxide (NO) participates in this effect. Adropin is a regulator of endothelial NO synthase and NO release, and circulating adropin level decreases with age. However, the effect of habitual aerobic exercise on circulating adropin levels in healthy middle-aged and older adults remains unclear. We sought to determine whether serum adropin level is associated with exercise training-induced changes in arterial stiffness. First, in a cross-sectional study, we investigated the association between serum adropin level and both arterial stiffness and cardiorespiratory fitness in 80 healthy middle-aged and older subjects (65.6 ± 0.9 yr). Second, in an intervention study, we examined the effects of 8-wk aerobic exercise training on serum adropin level and arterial stiffness in 40 healthy middle-aged and older subjects (67.3 ± 1.0 yr) divided into two groups: aerobic exercise training and sedentary controls. In the cross-sectional study, serum adropin level was negatively correlated with carotid β-stiffness (r = -0.437, P < 0.001) and positively correlated with plasma NOx level (r = 0.493, P < 0.001) and cardiorespiratory fitness (r = 0.457, P < 0.001). Serum adropin levels were elevated after the 8-wk aerobic exercise training intervention, and training-induced changes in serum adropin level were correlated with training-induced changes in carotid β-stiffness (r = -0.399, P < 0.05) and plasma NOx level (r = 0.623, P < 0.001). Thus the increase in adropin may participate in the exercise-induced reduction of arterial stiffness.
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: Shumpei
authors.initials: S
authors.lastname: Fujie
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: Natsuki
authors.initials: N
authors.lastname: Hasegawa
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Sato
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujita
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sanada
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Hamaoka
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan iemitsu@fc.ritsumei.ac.jp.
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Iemitsu
mesh_terms: D000368:Aged; D001786:Blood Glucose; D001798:Blood Proteins; D002339:Carotid Arteries / Q000503:physiopathology*; D008076:Cholesterol, HDL; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D010101:Oxygen Consumption; D010455:Peptides / Q000097:blood*; D010809:Physical Fitness; D011446:Prospective Studies; D014280:Triglycerides; D059289:Vascular Stiffness
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D008076:Cholesterol, HDL; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D014280:Triglycerides; D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
keywords: adropin; aging; carotid β-stiffness; exercise training; nitric oxide