title: Autophagy and autophagy-related proteins in the immune system.
abstract: Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond autophagy. In this Review, we introduce advances in the knowledge of the roles of autophagy and its components in immunity, including innate immunity, inflammatory responses and adaptive immunity.
authors.affiliation: Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.|Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: Shusaku T
authors.initials: ST
authors.lastname: Shibutani
authors.affiliation: Division of Molecular Genetics, Institute for Enzyme Research, Tokushima University, Tokushima, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Saitoh
authors.affiliation: Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
authors.forename: Heike
authors.initials: H
authors.lastname: Nowag
authors.affiliation: Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Münz
authors.affiliation: Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.|Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Yoshimori
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001343:Autophagy / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007113:Immunity, Innate; D011506:Proteins / Q000276:immunology*
chemical_list: D011506:Proteins