title: The spectrum of neutrophilic dermatoses associated with monoclonal gammopathy: Association with IgA isotype and inflammatory profile.
abstract: BACKGROUND
  Neutrophilic dermatoses refer to a group of cutaneous inflammatory disorders characterized by neutrophilic infiltration of the skin. Neutrophilic dermatoses have been reported in association with various conditions including autoimmune diseases, inflammatory bowel diseases, and neoplasia. In the later condition, myeloproliferative disorders and monoclonal gammopathy (monoclonal immunoglobulin [MIg]) are the most frequent. Only few data are available in case of neutrophilic dermatoses associated with MIg regarding the pathophysiology and the clinical outcome.
  
  
  OBJECTIVE
  We sought to gain further insight into clinical and biological aspects of neutrophilic dermatoses associated with MIg.
  
  
  METHODS
  We report a retrospective series of 26 patients with neutrophilic dermatoses associated with MIg focusing on clinical and biological aspects, with a study of a large panel of cytokines, chemokines, and adhesion molecules.
  
  
  RESULTS
  This study reveals an association between MIg IgA isotype and neutrophilic dermatoses, and a specific inflammatory pattern including elevated interleukin 6, vascular endothelial growth factor, monocyte chemotactic protein-1, epidermal growth factor, and intercellular adhesion molecule-1.
  
  
  CONCLUSIONS
  This is a retrospective study from a single institution with a limited number of participants.
  
  
  CONCLUSIONS
  Our data highlight a strong association between IgA isotype and neutrophilic dermatoses, and the existence of a specific inflammatory profile involving several molecules.
authors.affiliation: Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hopitaux de Paris, Paris, France; Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de Recherche (UMR)_1126, Institut Universitaire d'Hematologie, Universite Paris 7 Denis Diderot, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France. Electronic address: raphaelszalat@hotmail.com.
authors.forename: Raphael
authors.initials: R
authors.lastname: Szalat
authors.affiliation: Department of Dermatology, Saint-Louis Hospital, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Gentiane
authors.initials: G
authors.lastname: Monsel
authors.affiliation: INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Pitie-Salpetriere Hospitals, Paris, France.
authors.forename: Wilfried
authors.initials: W
authors.lastname: Le Goff
authors.affiliation: Department of Pathology, Saint-Louis Hospital, Paris, France; UMR_S1165, INSERM, Universite Paris 7 Denis Diderot, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Battistella
authors.affiliation: Department of Biological Immunology, Saint-Louis Hospital, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Djaouida
authors.initials: D
authors.lastname: Bengouffa
authors.affiliation: Cellular Biology Unit, Saint-Louis Hospital, Paris, France.
authors.forename: Marie-Helene
authors.initials: MH
authors.lastname: Schlageter
authors.affiliation: Department of Dermatology, Saint-Louis Hospital, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Jean-David
authors.initials: JD
authors.lastname: Bouaziz
authors.affiliation: Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hopitaux de Paris, Paris, France; Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de Recherche (UMR)_1126, Institut Universitaire d'Hematologie, Universite Paris 7 Denis Diderot, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Arnulf
authors.affiliation: Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hopitaux de Paris, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Marguerite
authors.initials: M
authors.lastname: Vignon
authors.affiliation: INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Pitie-Salpetriere Hospitals, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lesnik
authors.affiliation: Department of Dermatology, Saint-Louis Hospital, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Saussine
authors.affiliation: Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hopitaux de Paris, Paris, France; Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de Recherche (UMR)_1126, Institut Universitaire d'Hematologie, Universite Paris 7 Denis Diderot, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Malphettes
authors.affiliation: Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hopitaux de Paris, Paris, France; Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de Recherche (UMR)_1126, Institut Universitaire d'Hematologie, Universite Paris 7 Denis Diderot, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Lazareth
authors.affiliation: Department of Pathology, Saint-Louis Hospital, Paris, France.
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Vignon-Pennamen
authors.affiliation: Department of Dermatology, Saint-Louis Hospital, Paris, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Bagot
authors.affiliation: Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hopitaux de Paris, Paris, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Brouet
authors.affiliation: Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hopitaux de Paris, Paris, France; Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de Recherche (UMR)_1126, Institut Universitaire d'Hematologie, Universite Paris 7 Denis Diderot, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Fermand
authors.affiliation: Department of Dermatology, Saint-Louis Hospital, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Rybojad
authors.affiliation: Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hopitaux de Paris, Paris, France; Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de Recherche (UMR)_1126, Institut Universitaire d'Hematologie, Universite Paris 7 Denis Diderot, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
authors.forename: Bouchra
authors.initials: B
authors.lastname: Asli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015815:Cell Adhesion Molecules / Q000097:blood; D018925:Chemokines / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007132:Immunoglobulin Isotypes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010265:Paraproteinemias / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*; D012189:Retrospective Studies; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*
chemical_list: D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines; D007070:Immunoglobulin A; D007132:Immunoglobulin Isotypes
keywords: IgA isotype; autoimmunity; chemokines; cytokines; inflammatory profile; monoclonal gammopathy; neutrophilic dermatosis