title: Influenza D virus infection in Mississippi beef cattle.
abstract: A new member of the Orthomyxoviridae family, influenza D virus (IDV), was first reported in swine in the Midwest region of the United States. This study aims to extend our knowledge on the IDV epidemiology and to determine the impact of bovine production systems on virus spread. A total of 15 isolates were recovered from surveillance of bovine herds in Mississippi, and two genetic clades of viruses co-circulated in the same herd. Serologic assessment from neonatal beef cattle showed 94% seropositive, and presumed maternal antibody levels were substantially lower in animals over six months of age. Active IDV transmission was shown to occur at locations where young, weaned, and comingled calves were maintained. Serological characterization of archived sera suggested that IDV has been circulating in the Mississippi cattle populations since at least 2004. Continuous surveillance is needed to monitor the evolution and epidemiology of IDV in the bovine population.
authors.affiliation: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, MS 39762, United States.
authors.forename: Lucas
authors.initials: L
authors.lastname: Ferguson
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States.
authors.forename: Laura
authors.initials: L
authors.lastname: Eckard
authors.affiliation: Department of Population and Pathobiology Medicine, College of Veterinary Medicine, Mississippi State University, MS 39762, United States.
authors.forename: William B
authors.initials: WB
authors.lastname: Epperson
authors.affiliation: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, MS 39762, United States.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Long
authors.affiliation: Department of Population and Pathobiology Medicine, College of Veterinary Medicine, Mississippi State University, MS 39762, United States.
authors.forename: David
authors.initials: D
authors.lastname: Smith
authors.affiliation: Department of Population and Pathobiology Medicine, College of Veterinary Medicine, Mississippi State University, MS 39762, United States.
authors.forename: Carla
authors.initials: C
authors.lastname: Huston
authors.affiliation: Department of Population and Pathobiology Medicine, College of Veterinary Medicine, Mississippi State University, MS 39762, United States.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Genova
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States.
authors.forename: Richard
authors.initials: R
authors.lastname: Webby
authors.affiliation: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, MS 39762, United States. Electronic address: wan@cvm.msstate.edu.
authors.forename: Xiu-Feng
authors.initials: XF
authors.lastname: Wan
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000635:transmission / Q000821:virology*; D008922:Mississippi; D008969:Molecular Sequence Data; D009976:Orthomyxoviridae Infections / Q000097:blood / Q000635:transmission / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D018117:Thogotovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*
chemical_list: D000914:Antibodies, Viral
keywords: Beef cattle; Influenza D virus; Influenza virus; Maternal antibody; Mississippi; Serological surveillance; Surveillance