title: A Comprehensive Specimen-Specific Multiscale Data Set for Anatomical and Mechanical Characterization of the Tibiofemoral Joint.
abstract: Understanding of tibiofemoral joint mechanics at multiple spatial scales is essential for developing effective preventive measures and treatments for both pathology and injury management. Currently, there is a distinct lack of specimen-specific biomechanical data at multiple spatial scales, e.g., joint, tissue, and cell scales. Comprehensive multiscale data may improve the understanding of the relationship between biomechanical and anatomical markers across various scales. Furthermore, specimen-specific multiscale data for the tibiofemoral joint may assist development and validation of specimen-specific computational models that may be useful for more thorough analyses of the biomechanical behavior of the joint. This study describes an aggregation of procedures for acquisition of multiscale anatomical and biomechanical data for the tibiofemoral joint. Magnetic resonance imaging was used to acquire anatomical morphology at the joint scale. A robotic testing system was used to quantify joint level biomechanical response under various loading scenarios. Tissue level material properties were obtained from the same specimen for the femoral and tibial articular cartilage, medial and lateral menisci, anterior and posterior cruciate ligaments, and medial and lateral collateral ligaments. Histology data were also obtained for all tissue types to measure specimen-specific cell scale information, e.g., cellular distribution. This study is the first of its kind to establish a comprehensive multiscale data set for a musculoskeletal joint and the presented data collection approach can be used as a general template to guide acquisition of specimen-specific comprehensive multiscale data for musculoskeletal joints.
authors.affiliation: Computational Biomodeling (CoBi) Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, 44195, United States of America; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, 44195, United States of America.
authors.forename: Snehal
authors.initials: S
authors.lastname: Chokhandre
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, 44195, United States of America; BioRobotics and Mechanical Testing Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, 44195, United States of America.
authors.forename: Robb
authors.initials: R
authors.lastname: Colbrunn
authors.affiliation: Computational Biomodeling (CoBi) Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, 44195, United States of America; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, 44195, United States of America.
authors.forename: Craig
authors.initials: C
authors.lastname: Bennetts
authors.affiliation: Computational Biomodeling (CoBi) Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, 44195, United States of America; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, 44195, United States of America.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Erdemir
mesh_terms: D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000033:anatomy & histology / Q000502:physiology; D003198:Computer Simulation; D005269:Femur / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D007718:Knee Injuries / Q000473:pathology / Q000503:physiopathology; D007719:Knee Joint / Q000033:anatomy & histology* / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008954:Models, Biological; D016059:Range of Motion, Articular / Q000502:physiology; D013314:Stress, Mechanical; D013977:Tibia / Q000033:anatomy & histology / Q000502:physiology*