title: Pubertal BPA exposure changes central ERα levels in female mice.
abstract: Despite many studies on the effects of perinatal Bisphenol A (BPA) exposure on the brain, its effects on brain estrogen receptor (ERα) expression during puberty remain unclear. Here, mice were injected subcutaneously with BPA (50μg/kg), estradiol (10μg 17β-E2/kg) or oil (0.05ml sesame oil) daily during puberty (postnatal days 23-30). Immunohistochemistry was used to examine changes in ERα immunoreactive neurons in different brain regions. Compared to control animals, pubertal exposure to BPA significantly increased ERα immunoreactive neurons in the bed nucleus of the stria terminalis (BST), arcuate hypothalamic nucleus (Arc), ventromedial hypothalamic nucleus (VMH) and medial amygdaloid nucleus (MeA) in females. E2 exposure during puberty also increased ERα immunoreactive neurons in the lateral septum (LS) of females. No effect was detected in males. These results indicate that the effects of estrogenic chemicals on ERα immunoreactive neurons are sex-dependent.
authors.affiliation: Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, China; School of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, China.
authors.forename: Cheng J
authors.initials: CJ
authors.lastname: Yu
authors.affiliation: Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.
authors.forename: Qian Q
authors.initials: QQ
authors.lastname: Fang
authors.affiliation: Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, China. Electronic address: taifadao@snnu.edu.cn.
authors.forename: Fa D
authors.initials: FD
authors.lastname: Tai
mesh_terms: D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects / Q000378:metabolism; D001559:Benzhydryl Compounds / Q000008:administration & dosage* / Q000633:toxicity; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D066276:Corticomedial Nuclear Complex / Q000187:drug effects / Q000378:metabolism; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D010636:Phenols / Q000008:administration & dosage* / Q000633:toxicity; D012686:Septal Nuclei / Q000187:drug effects / Q000378:metabolism; D012715:Sesame Oil / Q000008:administration & dosage / Q000494:pharmacology; D012737:Sex Factors; D012741:Sexual Maturation / Q000187:drug effects*; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004958:Estradiol; D047628:Estrogen Receptor alpha; D010636:Phenols; D012715:Sesame Oil; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: 17β-Estradiol; Bisphenol A; Brain; Estrogen receptor α; Puberty