title: Placental α-Microglobulin-1 in Vaginal Secretions of Women with Evidence of Preterm Labor.
abstract: OBJECTIVE
  To evaluate the presence of placental α-microglobulin-1 (PAMG-1) in vaginal secretions in women with symptoms of preterm labor and assess its use as a predictor of preterm birth.
  
  
  METHODS
  A prospective cohort study of women between 16 and 34 weeks of gestation with symptoms of preterm labor and intact membranes was conducted. The presence of PAMG-1 was determined using a commercially available kit (AmniSure, AmniSure International LLC, Boston, MA).
  
  
  RESULTS
  A total of 100 women were enrolled, of which 86 had outcome data available. PAMG-1 was detected in 19/86 (22.1%) subjects. These women were more likely to deliver within 7 days than those without PAMG-1 detected (6/19 [31.6%] vs. 5/67 [7.5%]; odds ratio 5.6; 95% confidence interval 1.5-21.6). These findings persisted after adjusting for potential confounders. The sensitivity was 54.6%, specificity was 82.7%, positive predictive value was 31.6%, and the negative predictive was 92.5%.
  
  
  CONCLUSIONS
  The presence of PAMG-1 is associated with an increased likelihood of delivery within 7 days.
authors.affiliation: Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Ehsanipoor
authors.affiliation: Department of Obstetrics and Gynecology, University of California, Irvine, California.
authors.forename: Morgan L
authors.initials: ML
authors.lastname: Swank
authors.affiliation: Center of Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Seung Chik
authors.initials: SC
authors.lastname: Jwa
authors.affiliation: Department of Obstetrics and Gynecology, University of California, Irvine, California.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Wing
authors.affiliation: Department of Internal Medicine, West Virginia University School of Medicine, Virginia.
authors.forename: Gofran
authors.initials: G
authors.lastname: Tarabulsi
authors.affiliation: Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Karin J
authors.initials: KJ
authors.lastname: Blakemore
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D007752:Obstetric Labor, Premature / Q000175:diagnosis / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D047928:Premature Birth / Q000453:epidemiology / Q000378:metabolism*; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D014621:Vagina; D055815:Young Adult
chemical_list: C403421:FFN protein, human; D005353:Fibronectins; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1