title: Do women with statin-related myalgias have low vitamin D levels?
abstract: BACKGROUND
  Statin intolerance is often due to myalgias. Severe vitamin D deficiency is characterized by musculoskeletal pain. We hypothesized that statin-intolerance is associated with vitamin D deficiency.
  
  
  OBJECTIVE
  To determine whether there is an association between statin-intolerance and vitamin D deficiency in a retrospective observational analysis.
  
  
  METHODS
  We evaluated 20 female patients with prior myalgia-related daily dose statin intolerance on an alternative day statin dosing protocol of twice weekly for 4 weeks followed by advancement to daily dosing, as tolerated. Fasting baseline and follow-up lipid and 25-hydroxy-vitamin D (25-OHD) levels were obtained by chart review.
  
  
  RESULTS
  The group median age was 61 ± 13 years old and BMI was 27 ± 7 kg/m(2). Women who remained on alternative day statin dosing (n = 16) compared to women on daily dosing (n = 4) had a significantly lower group mean 25-OHD (mean 29 ± 11.23 vs. 47.5 ± 23.53 ng/ml p = 0.0307 respectively).
  
  
  CONCLUSIONS
  In women with prior myalgia-related statin intolerance, vitamin D levels were significantly lower in women who remained on alternative day dosing compared to those who were tolerant of daily dosing.
authors.affiliation: The Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles, CA, 90048, USA. MinissianM@cshs.org.
authors.forename: Margo
authors.initials: M
authors.lastname: Minissian
authors.affiliation: The Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles, CA, 90048, USA. megha.agarwal924@gmail.com.
authors.forename: Megha
authors.initials: M
authors.lastname: Agarwal
authors.affiliation: The Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles, CA, 90048, USA. shufeltc@cshs.org.
authors.forename: Chrisandra
authors.initials: C
authors.lastname: Shufelt
authors.affiliation: The Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles, CA, 90048, USA. mehtapk@cshs.org.
authors.forename: Puja K
authors.initials: PK
authors.lastname: Mehta
authors.affiliation: The Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles, CA, 90048, USA. Talya.Waldman@cshs.org.
authors.forename: Talya
authors.initials: T
authors.lastname: Waldman
authors.affiliation: The Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles, CA, 90048, USA. Greg.Lentz@cshs.org.
authors.forename: Greg
authors.initials: G
authors.lastname: Lentz
authors.affiliation: The Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles, CA, 90048, USA. Galen.Cook-Wiens@cshs.org.
authors.forename: Galen
authors.initials: G
authors.lastname: Cook-Wiens
authors.affiliation: The Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles, CA, 90048, USA. jeastwoo@sonnet.ucla.edu.
authors.forename: Jo-Ann
authors.initials: JA
authors.lastname: Eastwood
authors.affiliation: The Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP Suite A9306, Los Angeles, CA, 90048, USA. merz@cshs.org.
authors.forename: C
authors.initials: C
authors.lastname: Noel Bairey Merz
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008875:Middle Aged; D063806:Myalgia / Q000139:chemically induced*; D010865:Pilot Projects; D012189:Retrospective Studies; D014807:Vitamin D / Q000097:blood*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014807:Vitamin D