title: Epigenetic regulation of ageing: linking environmental inputs to genomic stability.
abstract: Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-based epigenetic changes that occur during ageing, the role of chromatin modifiers in modulating lifespan and the importance of epigenetic signatures as biomarkers of ageing. We also discuss how epigenome remodelling by environmental stimuli affects several aspects of transcription and genomic stability, with important consequences for longevity, and outline epigenetic differences between the 'mortal soma' and the 'immortal germ line'. Finally, we discuss the inheritance of characteristics of ageing and potential chromatin-based strategies to delay or reverse hallmarks of ageing or age-related diseases.
authors.affiliation: Department of Genetics, Stanford University, Stanford, California 94305, USA.|Paul F. Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, California 94305, USA.
authors.forename: Bérénice A
authors.initials: BA
authors.lastname: Benayoun
authors.affiliation: Department of Genetics, Stanford University, Stanford, California 94305, USA.|Cancer Biology Program, Stanford University, Stanford, California 94305, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Pollina
authors.affiliation: Department of Genetics, Stanford University, Stanford, California 94305, USA.|Paul F. Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, California 94305, USA.|Cancer Biology Program, Stanford University, Stanford, California 94305, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Brunet
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002843:Chromatin / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D044127:Epigenesis, Genetic; D059647:Gene-Environment Interaction; D042822:Genomic Instability; D006801:Humans
chemical_list: D015415:Biomarkers; D002843:Chromatin