title: Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise.
abstract: The myocardial response to exercise is an adaptive mechanism that permits the heart to maintain cardiac output via improved cardiac function and development of hypertrophy. There are many overlapping mechanisms via which this occurs with calcium handling being a crucial component of this process. Our laboratory has previously found that the stretch sensitive TRPV2 channels are active regulators of calcium handling and cardiac function under baseline conditions based on our observations that TRPV2-KO mice have impaired cardiac function at baseline. The focus of this study was to determine the cardiac function of TRPV2-KO mice under exercise conditions. We measured skeletal muscle at baseline in WT and TRPV2-KO mice and subjected them to various exercise protocols and measured the cardiac response using echocardiography and molecular markers. Our results demonstrate that the TRPV2-KO mouse did not tolerate forced exercise although they became increasingly exercise tolerant with voluntary exercise. This occurs as the cardiac function deteriorates further with exercise. Thus, our conclusion is that TRPV2-KO mice have impaired cardiac functional response to exercise.
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Mindi
authors.initials: M
authors.lastname: Naticchioni
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Karani
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Smith
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Evan
authors.initials: E
authors.lastname: Onusko
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Nathan
authors.initials: N
authors.lastname: Robbins
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Radzyukevich
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Logan
authors.initials: L
authors.lastname: Fulford
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Xu
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Ryan
authors.initials: R
authors.lastname: Apel
authors.affiliation: Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Judith
authors.initials: J
authors.lastname: Heiny
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Jack
authors.initials: J
authors.lastname: Rubinstein
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Health & Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Sheryl E
authors.initials: SE
authors.lastname: Koch
mesh_terms: D000818:Animals; D015153:Blotting, Western; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D004562:Electrocardiography; D005786:Gene Expression Regulation; D007150:Immunohistochemistry; D008297:Male; D018345:Mice, Knockout; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D060888:Real-Time Polymerase Chain Reaction; D013312:Stress, Physiological; D050916:TRPV Cation Channels / Q000235:genetics / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D050916:TRPV Cation Channels; C485717:Trpv2 protein, mouse