title: Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome.
abstract: Depression is a major public health concern in modern society, yet little is known about the molecular link between this condition and neuroinflammation. The inflammasome complex was recently shown to be implicated in depression. The present study shows the implication of NLRP3 inflammasome in animal model of stress-induced depression. Accordingly, we show here that in the absence of a NLRP3 inflammasome, prolonged stress does not provoke depressive behaviors or microglial activation in mice or dampen hippocampal neurogenesis. Indeed, NLRP3 deletion or inhibition of microglial activation impairs the stress-induced alterations associated with depression. According to these findings in animal model, the inflammasome could be a target for new therapeutic interventions to prevent depression in patients.
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 41013, Sevilla, Spain.
authors.forename: Elísabet
authors.initials: E
authors.lastname: Alcocer-Gómez
authors.affiliation: Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide de Sevilla, Carretera de Utrera Km. 1, 41013, Sevilla, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Ulecia-Morón
authors.affiliation: Research Laboratory, Dental School, University of Sevilla, Sevilla, Spain.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Marín-Aguilar
authors.affiliation: Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide de Sevilla, Carretera de Utrera Km. 1, 41013, Sevilla, Spain.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Rybkina
authors.affiliation: Dpto. Psiquiatría, Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain.
authors.forename: Nieves
authors.initials: N
authors.lastname: Casas-Barquero
authors.affiliation: CIBER de Enfermedades Respiratorias, Madrid, Spain; Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares and Universidad Complutense Madrid, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Ruiz-Cabello
authors.affiliation: CNRS, UMR7355, Orléans, France.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ryffel
authors.affiliation: INSERM, UMR866, Dijon, France.|Centre Georges François Leclerc, Dijon, France.|Université de Bourgogne, Dijon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Apetoh
authors.affiliation: INSERM, UMR866, Dijon, France.|Centre Georges François Leclerc, Dijon, France.|Université de Bourgogne, Dijon, France.
authors.forename: François
authors.initials: F
authors.lastname: Ghiringhelli
authors.affiliation: Research Laboratory, Dental School, University of Sevilla, Sevilla, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Bullón
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 41013, Sevilla, Spain.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Sánchez-Alcazar
authors.affiliation: Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide de Sevilla, Carretera de Utrera Km. 1, 41013, Sevilla, Spain. amancar@upo.es.
authors.forename: Angel M
authors.initials: AM
authors.lastname: Carrión
authors.affiliation: Research Laboratory, Dental School, University of Sevilla, Sevilla, Spain. mdcormor@us.es.|IBiS Institute of Biomedicine of Seville, University Hospital Virgen del Rocío-CSIC-University of Seville Spain, Sevilla, Spain. mdcormor@us.es.|IBiS Institute of Biomedicine of Seville, Universidad de Sevilla, C/Calle Antonio Maura Montaner s/n, 41013, Sevilla, Spain. mdcormor@us.es.
authors.forename: Mario D
authors.initials: MD
authors.lastname: Cordero
mesh_terms: D000818:Animals; D003863:Depression / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D058847:Inflammasomes / Q000172:deficiency*; D007398:Interpersonal Relations; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017628:Microglia / Q000378:metabolism / Q000473:pathology; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000172:deficiency*; D017397:Prefrontal Cortex / Q000378:metabolism / Q000473:pathology; D013315:Stress, Psychological / Q000378:metabolism* / Q000473:pathology / Q000523:psychology
chemical_list: D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse
keywords: Depression; Inflammasome; Microglia; Stress