title: Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide.
abstract: Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agents that are taken up by inflammatory cells can detect cellular inflammation non-invasively using CMR, potentially aiding the diagnosis of inflammatory medical conditions, guiding their treatment and giving insight into their pathophysiology. In this review we describe the utilization of USPIO as a novel contrast agent in vascular disease.
authors.affiliation: Centre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. s.r.alam@sms.ed.ac.uk.|Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 5SA, UK. s.r.alam@sms.ed.ac.uk.
authors.forename: Shirjel R
authors.initials: SR
authors.lastname: Alam
authors.affiliation: Centre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. cstirrat@exseed.ed.ac.uk.|Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 5SA, UK. cstirrat@exseed.ed.ac.uk.
authors.forename: Colin
authors.initials: C
authors.lastname: Stirrat
authors.affiliation: Centre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. jenny.Robson@ed.ac.uk.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Richards
authors.affiliation: Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, EH16 5SA, UK. Saeed.Mirsadraee@ed.ac.uk.|Department of Radiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 5SA, UK. Saeed.Mirsadraee@ed.ac.uk.
authors.forename: Saeed
authors.initials: S
authors.lastname: Mirsadraee
authors.affiliation: Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, EH16 5SA, UK. scott.semple@ed.ac.u.
authors.forename: Scott I K
authors.initials: SI
authors.lastname: Semple
authors.affiliation: MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, EH16 5SA, UK. gtse@staffmail.ed.ac.uk.
authors.forename: George
authors.initials: G
authors.lastname: Tse
authors.affiliation: Centre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. peter.Henriksen@nhslothian.scot.nhs.uk.|Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 5SA, UK. peter.Henriksen@nhslothian.scot.nhs.uk.
authors.forename: Peter
authors.initials: P
authors.lastname: Henriksen
authors.affiliation: Centre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. D.E.Newby@ed.ac.uk.|Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 5SA, UK. D.E.Newby@ed.ac.uk.
authors.forename: David E
authors.initials: DE
authors.lastname: Newby
mesh_terms: D000818:Animals; D001158:Arteries / Q000378:metabolism / Q000473:pathology*; D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage* / Q000378:metabolism; D003911:Dextrans / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D008264:Macrophages / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*; D010316:Particle Size; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; C097921:ferumoxtran-10