title: Intracameral epinephrine without the addition of intracameral lidocaine in the management of tamsulosin associated intraoperative floppy iris syndrome.
abstract: OBJECTIVE
  Intracameral mydriatics using epinephrine associated with lidocaine have been reported as efficacious in reducing intraoperative floppy iris syndrome (IFIS) complications during cataract surgery. The aim of this study was to verify the efficacy of intracameral epinephrine without intracameral lidocaine as prophylaxis against IFIS in patients on tamsulosin.
  
  
  METHODS
  This was a retrospective study on the results of cataract surgery in 18 patients on therapy with tamsulosin. Patients had undergone routine phacoemulsification in one eye. Successively, they underwent phacoemulsifcation in the fellow eye using non preserved intracameral epinephrine 1:4000 diluted with BSS. Intraoperative complications during cataract surgery had been documented and IFIS was graded based on iris billowing, miosis or iris prolapse. Follow-up was 3 months.
  
  
  RESULTS
  Thirty-six eyes of 18 patients were included in the evaluation. The incidence of IFIS was significantly higher in the eyes where routine phacoemulsificaton had been performed (100%) with respect to eyes where phacoemulsification was carried out using intracameral epinephrine (33%) (Chi Square test =15.12, p<0.001). In routine phacoemulsification 16 eyes showed iris billowing, 14 eyes had some extent of miosis and 14 eyes had tendency to iris prolapse. In phacoemulsification with the use of intracameral epinephrine 5 eyes showed iris billowing, 4 eyes presented some extent of miosis and 2 eyes had tendency to iris prolapse. There were no serious intraoperative complications.
  
  
  CONCLUSIONS
  Intracameral epinephrine without the addition of lidocaine was efficacious in the management of IFIS in patients on tamsulosin.
authors.affiliation: Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital.
authors.forename: V
authors.initials: V
authors.lastname: Fenicia
authors.affiliation: Ophthalmology Unit, DAI Head/Neck, Policlinico Umberto I Hospital, University Sapienza, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Abdolrahimzadeh
authors.affiliation: Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital.
authors.forename: G
authors.initials: G
authors.lastname: Scuderi
authors.affiliation: Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital.
authors.forename: L
authors.initials: L
authors.lastname: Fabrizio
authors.affiliation: Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Maurizi Enrici
authors.affiliation: Ophthalmology Unit, DAI Head/Neck, Policlinico Umberto I Hospital, University Sapienza, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cruciani
authors.affiliation: Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital.
authors.forename: S M
authors.initials: SM
authors.lastname: Recupero
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000009:adverse effects*; D000368:Aged; D004837:Epinephrine / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced / Q000517:prevention & control*; D007499:Iris Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D009184:Mydriatics / Q000627:therapeutic use*; D018918:Phacoemulsification; D012189:Retrospective Studies; D013449:Sulfonamides / Q000009:adverse effects*; D013577:Syndrome; D000077409:Tamsulosin; D016896:Treatment Outcome
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D009184:Mydriatics; D013449:Sulfonamides; D008012:Lidocaine; D000077409:Tamsulosin; D004837:Epinephrine
keywords: Intracameral lidocaine; Intraoperative floppy iris syndrome, intracameral epinephrine; Tamsulosin; α1-adrenergic receptor antagonists