title: Revisiting the challenges of universal screening for long QT syndrome.
abstract: The incidence of long QT syndrome (LQTS) is generally believed to be approximately 1:2500 individuals. Given the relatively common nature of this disorder, the observation that sudden cardiac death is often a presenting symptom and the highly treatable nature of the disease, LQTS meets common criteria for the design of a universal screening program. In spite of multiple lines of evidence (international experience, cost-benefit simulations) suggesting that universal screening for LQTS is feasible and effective, there remains considerable debate and controversy surrounding the implementation of universal LQTS screening in the United States. Here, we describe some of the challenges and potential novel solutions to the practical implementation of LQTS screening.
authors.affiliation: Division of Pediatric Cardiology, 81 N. Mario Capecchi Drive, Salt Lake City, UT, USA; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, 95 S. 2000 E, Salt Lake City, UT, USA. Electronic address: Martin.Tristani@utah.edu.
authors.forename: Martin
authors.initials: M
authors.lastname: Tristani-Firouzi
mesh_terms: D003951:Diagnostic Errors / Q000517:prevention & control / Q000706:statistics & numerical data*; D042241:Early Diagnosis; D004562:Electrocardiography / Q000706:statistics & numerical data*; D006801:Humans; D008133:Long QT Syndrome / Q000175:diagnosis* / Q000453:epidemiology*; D008403:Mass Screening / Q000379:methods* / Q000706:statistics & numerical data*; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity
keywords: Arrhythmia; Electrocardiogram; Long QT syndrome; Sudden cardiac death; Universal screening