title: Detection and characterization of early malignancy in the esophagus: what is the best management algorithm?
abstract: Barrett's esophagus is a known precursor for esophageal adenocarcinoma. Early detection of dysplasia provides a window of opportunity for curative intervention. Several image-enhanced technologies have been developed to improve visualization of neoplasia. These however have not been found to be superior to the standard four quadrant random biopsy protocol. Patients are risk-stratified based on the degree of dysplasia found on biopsies and undergo either surveillance or treatment. Endoscopic therapy has become the mainstay of treatment for early neoplasia.
authors.affiliation: The Lyell McEwin Hospital & University of Adelaide Endoscopy Unit, Haydown Road, Elizabeth Vale, SA 5112, Australia. Electronic address: rajvinder.singh@health.sa.gov.au.
authors.forename: Rajvinder
authors.initials: R
authors.lastname: Singh
authors.affiliation: The Lyell McEwin Hospital & University of Adelaide Endoscopy Unit, Haydown Road, Elizabeth Vale, SA 5112, Australia.
authors.forename: Sze Pheh
authors.initials: SP
authors.lastname: Yeap
authors.affiliation: The Lyell McEwin Hospital & University of Adelaide Endoscopy Unit, Haydown Road, Elizabeth Vale, SA 5112, Australia.
authors.forename: Kuan Loong
authors.initials: KL
authors.lastname: Cheong
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000465:Algorithms; D001471:Barrett Esophagus / Q000175:diagnosis*; D055088:Early Detection of Cancer; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D004945:Esophagoscopy / Q000379:methods; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008679:Metaplasia; D018613:Microscopy, Confocal
keywords: Argon plasma coagulation; Autofluorescence imaging; Barrett's esophagus; Chromoendoscopy; Confocal laser endomicroscopy; Early esophageal adenocarcinoma; Endoscopic mucosal resection; Image-enhanced endoscopy; Intestinal metaplasia; Narrow band imaging; Radiofrequency ablation; Seattle protocol