title: Chronic lymphocytic thyroiditis is associated with invasive characteristics of differentiated thyroid carcinoma in children and adolescents.
abstract: The association between chronic lymphocytic thyroiditis (CLT) and thyroid cancer is an interesting topic. The aim of the present study was to evaluate if demographic and histological characteristics as well as the long-term outcome of thyroid cancer was different in children and adolescents with and without CLT.
  
  
  
  The medical records of children and adolescents (≤21 years old) were reviewed. The following data were recorded: gender, year and age at diagnosis, family history of thyroid cancer, history of external radiation therapy, histological type (papillary and variants, follicular and variants), tumour size, multifocality, infiltration of thyroid parenchyma or surrounding soft tissues, vascular invasion, presence of lymph node and distant metastases. Information about the presence of TgAb and TPOAb was also collected.
  
  
  
  One hundred eight children and adolescents (median age 19.0, interquartile range 4.0 years) were diagnosed with differentiated thyroid carcinoma (DTC); 31 patients (28.7%) presented histological characteristics compatible with CLT. Infiltration of thyroid parenchyma was more frequent in patients with CLT compared to patients without (74.2% vs 48.1% respectively, P=0.024). Familial papillary thyroid carcinoma (PTC) was more frequent in patients with CLT compared to those without CLT (20.7% vs 2.8% respectively, P=0.009). There was no better outcome with respect to the presence of CLT or not.
  
  
  
  Children and adolescents with CLT present more frequently familial PTC as well as thyroid cancer with invasive characteristics.
authors.affiliation: Department of EndocrinologyTheagenio Cancer Hospital, 2, Al Simeonidi Street, 54007 Thessaloniki, GreeceEndocrinology SectionInternal Medicine Department, Nykobing Falster Hospital, Nykobing Falster, DenmarkDepartment of PathologyTheagenio Cancer Hospital, Thessaloniki, Greece.
authors.forename: Paschalia K
authors.initials: PK
authors.lastname: Iliadou
authors.affiliation: Department of EndocrinologyTheagenio Cancer Hospital, 2, Al Simeonidi Street, 54007 Thessaloniki, GreeceEndocrinology SectionInternal Medicine Department, Nykobing Falster Hospital, Nykobing Falster, DenmarkDepartment of PathologyTheagenio Cancer Hospital, Thessaloniki, Greece.
authors.forename: Grigoris
authors.initials: G
authors.lastname: Effraimidis
authors.affiliation: Department of EndocrinologyTheagenio Cancer Hospital, 2, Al Simeonidi Street, 54007 Thessaloniki, GreeceEndocrinology SectionInternal Medicine Department, Nykobing Falster Hospital, Nykobing Falster, DenmarkDepartment of PathologyTheagenio Cancer Hospital, Thessaloniki, Greece.
authors.forename: Michalakis
authors.initials: M
authors.lastname: Konstantinos
authors.affiliation: Department of EndocrinologyTheagenio Cancer Hospital, 2, Al Simeonidi Street, 54007 Thessaloniki, GreeceEndocrinology SectionInternal Medicine Department, Nykobing Falster Hospital, Nykobing Falster, DenmarkDepartment of PathologyTheagenio Cancer Hospital, Thessaloniki, Greece.
authors.forename: Panagiotou
authors.initials: P
authors.lastname: Grigorios
authors.affiliation: Department of EndocrinologyTheagenio Cancer Hospital, 2, Al Simeonidi Street, 54007 Thessaloniki, GreeceEndocrinology SectionInternal Medicine Department, Nykobing Falster Hospital, Nykobing Falster, DenmarkDepartment of PathologyTheagenio Cancer Hospital, Thessaloniki, Greece.
authors.forename: Periklis
authors.initials: P
authors.lastname: Mitsakis
authors.affiliation: Department of EndocrinologyTheagenio Cancer Hospital, 2, Al Simeonidi Street, 54007 Thessaloniki, GreeceEndocrinology SectionInternal Medicine Department, Nykobing Falster Hospital, Nykobing Falster, DenmarkDepartment of PathologyTheagenio Cancer Hospital, Thessaloniki, Greece.
authors.forename: Frideriki
authors.initials: F
authors.lastname: Patakiouta
authors.affiliation: Department of EndocrinologyTheagenio Cancer Hospital, 2, Al Simeonidi Street, 54007 Thessaloniki, GreeceEndocrinology SectionInternal Medicine Department, Nykobing Falster Hospital, Nykobing Falster, DenmarkDepartment of PathologyTheagenio Cancer Hospital, Thessaloniki, Greece kpazaitou@in.gr.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Pazaitou-Panayiotou
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000453:epidemiology* / Q000473:pathology; D000293:Adolescent; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology; D002291:Carcinoma, Papillary; D002648:Child; D015331:Cohort Studies; D005260:Female; D050031:Hashimoto Disease / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000473:pathology; D055815:Young Adult