title: Effects of central gastrin-releasing peptide on glucose metabolism.
abstract: Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP caused an immediate hyperglycaemia which was sustained till the end of the infusion. The rise in plasma glucose levels was accompanied by an increase in endogenous glucose production (EGP), as well as increases in plasma glucagon and insulin concentrations. Furthermore, no differences in plasma corticosterone levels were noted between control and GRP treated rats. These results demonstrate that central GRP increases plasma glucose levels, probably by stimulating pancreatic glucagon release and concomitantly or subsequently endogenous glucose production.
authors.affiliation: Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands; Regulation of Circadian Clocks team, Institute of Cellular and Integrative Neurosciences, UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, France; International Associated Laboratory LIA1061 Understanding the Neural Basis of Diurnality, CNRS, France and the Netherlands. Electronic address: kj.pawan@gmail.com.
authors.forename: Pawan Kumar
authors.initials: PK
authors.lastname: Jha
authors.affiliation: Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, The Netherlands. Electronic address: e.foppen@nin.knaw.nl.
authors.forename: Ewout
authors.initials: E
authors.lastname: Foppen
authors.affiliation: Regulation of Circadian Clocks team, Institute of Cellular and Integrative Neurosciences, UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, France; International Associated Laboratory LIA1061 Understanding the Neural Basis of Diurnality, CNRS, France and the Netherlands. Electronic address: challet@inci-cnrs.unistra.fr.
authors.forename: Etienne
authors.initials: E
authors.lastname: Challet
authors.affiliation: Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands; Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, The Netherlands; International Associated Laboratory LIA1061 Understanding the Neural Basis of Diurnality, CNRS, France and the Netherlands. Electronic address: a.kalsbeek@amc.uva.nl.
authors.forename: Andries
authors.initials: A
authors.lastname: Kalsbeek
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood; D019886:Gastrin-Releasing Peptide / Q000008:administration & dosage*; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D005934:Glucagon / Q000097:blood; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D007276:Injections, Intraventricular; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005765:Gastrointestinal Agents; D007328:Insulin; D019886:Gastrin-Releasing Peptide; D005934:Glucagon; D003345:Corticosterone
keywords: Endogenous glucose production; Glucagon; Hypothalamus; Paraventricular nuclei; Suprachiasmatic nuclei