title: Two friends with eroded nodules on the ears: atypical fibroxanthoma case report.
abstract: Atypical fibroxanthoma is an uncommon mesenchymal tumor that manifests clinically as a reddish papule or nodule in sun-exposed areas of the body. The clinical presentation is not specific and histology and immunohistochemistry are both necessary for a correct diagnosis. Surgery is the gold standard of therapy. Recurrence and metastasis should be excluded with a follow-up at 6 months, since this tumor should nowadays be considered a medium-grade neoplasm, rather than low-grade as previously believed. We report the case of two friends who came to our hospital during the same period, complaining of very similar lesions. After biopsy and immunohistochemical examination, a diagnosis of atypical fibroxanthoma in both cases was formulated.
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, IT.
authors.forename: Filippo
authors.initials: F
authors.lastname: Pesapane
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, IT.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Nazzaro
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, IT.
authors.forename: Luisa
authors.initials: L
authors.lastname: Lunardon
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, IT.
authors.forename: Antonella
authors.initials: A
authors.lastname: Coggi
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, IT.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Gianotti
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D054644:Ear Auricle / Q000473:pathology*; D004428:Ear Neoplasms / Q000473:pathology*; D005350:Fibroma / Q000473:pathology*; D033062:Friends; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*; D014973:Xanthomatosis / Q000473:pathology*