title: A Real-Time Atrial Fibrillation Detection Algorithm Based on the Instantaneous State of Heart Rate.
abstract: Atrial fibrillation (AF), the most frequent cause of cardioembolic stroke, is increasing in prevalence as the population ages, and presents with a broad spectrum of symptoms and severity. The early identification of AF is an essential part for preventing the possibility of blood clotting and stroke. In this work, a real-time algorithm is proposed for accurately screening AF episodes in electrocardiograms. This method adopts heart rate sequence, and it involves the application of symbolic dynamics and Shannon entropy. Using novel recursive algorithms, a low-computational complexity can be obtained. Four publicly-accessible sets of clinical data (Long-Term AF, MIT-BIH AF, MIT-BIH Arrhythmia, and MIT-BIH Normal Sinus Rhythm Databases) were used for assessment. The first database was selected as a training set; the receiver operating characteristic (ROC) curve was performed, and the best performance was achieved at the threshold of 0.639: the sensitivity (Se), specificity (Sp), positive predictive value (PPV) and overall accuracy (ACC) were 96.14%, 95.73%, 97.03% and 95.97%, respectively. The other three databases were used for independent testing. Using the obtained decision-making threshold (i.e., 0.639), for the second set, the obtained parameters were 97.37%, 98.44%, 97.89% and 97.99%, respectively; for the third database, these parameters were 97.83%, 87.41%, 47.67% and 88.51%, respectively; the Sp was 99.68% for the fourth set. The latest methods were also employed for comparison. Collectively, results presented in this study indicate that the combination of symbolic dynamics and Shannon entropy yields a potent AF detector, and suggest this method could be of practical use in both clinical and out-of-clinical settings.
authors.affiliation: CAS/CUHK Research Centre for Biosensors and Medical Instruments, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; The Key Laboratory for Health Informatics of the Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: CAS/CUHK Research Centre for Biosensors and Medical Instruments, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; The Key Laboratory for Health Informatics of the Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Ding
authors.affiliation: CAS/CUHK Research Centre for Biosensors and Medical Instruments, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; The Key Laboratory for Health Informatics of the Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.affiliation: CAS/CUHK Research Centre for Biosensors and Medical Instruments, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; The Key Laboratory for Health Informatics of the Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
authors.forename: Yuanting
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000503:physiopathology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography; D006339:Heart Rate; D000069550:Machine Learning; D011237:Predictive Value of Tests; D012372:ROC Curve