title: Prevalence of Sarcopenia and Its Relationship with Sites of Fragility Fractures in Elderly Chinese Men and Women.
abstract: OBJECTIVE
  Sarcopenia might be associated with bone fragility in elderly individuals. This study aimed to investigate the prevalence of sarcopenia and its association with fragility fracture sites in elderly Chinese patients.
  
  
  METHODS
  Patients (322 men and 435 women) aged 65-94 years and with a history of fragility fractures in the ankle, wrist, vertebrae or hip, and healthy men (n = 1263) and women (n = 1057) aged 65-92 years without a history of fractures were enrolled. Whole-body dual energy X-ray absorptiometry was used to analyze skeletal muscle mass index (SMI), fat mass and bone mineral density. Sarcopenia was defined as SMI less than two standard deviations below the mean of a young reference group.
  
  
  RESULTS
  Sarcopenia occurrence varied with fracture location. Sarcopenia was more common in females with vertebral and hip fractures and in men with hip and ankle fractures than in the non-fracture group). Sarcopenia was significantly more prevalent in men with wrist, hip and ankle fractures than in women. SMI was correlated with BMD in different fracture groups. Logistic regression analyses revealed that lower SMI was associated with an increased risk of hip fracture both in men and women and ankle fracture in men.
  
  
  CONCLUSIONS
  Sarcopenia may be an independent risk factor for hip and ankle fractures in men, and for hip fractures in women.
authors.affiliation: Department of Osteoporosis, Research Section of Geriatric Metabolic Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hong
authors.affiliation: Department of Osteoporosis, Research Section of Geriatric Metabolic Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Department of Osteoporosis, Research Section of Geriatric Metabolic Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Osteoporosis, Research Section of Geriatric Metabolic Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Hanmin
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Osteoporosis, Research Section of Geriatric Metabolic Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Osteoporosis, Research Section of Geriatric Metabolic Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Songbai
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of Osteoporosis, Research Section of Geriatric Metabolic Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Osteoporosis, Research Section of Geriatric Metabolic Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Osteoporosis, Research Section of Geriatric Metabolic Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Sihong
authors.initials: S
authors.lastname: Xue
authors.affiliation: Department of Nephrology, Huadong Hospital affiliated to Fudan University, Shanghai, China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Ye
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D064386:Ankle Fractures / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D044466:Asian People; D002681:China; D005260:Female; D006620:Hip Fractures / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology; D055948:Sarcopenia / Q000150:complications / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D012727:Sex Characteristics