title: New Vaccines for the World's Poorest People.
abstract: The 2000 Millennium Development Goals helped stimulate the development of life-saving childhood vaccines for pneumococcal and rotavirus infections while greatly expanding coverage of existing vaccines. However, there remains an urgent need to develop new vaccines for HIV/AIDS, malaria, and tuberculosis, as well as for respiratory syncytial virus and those chronic and debilitating (mostly parasitic) infections known as neglected tropical diseases (NTDs). The NTDs represent the most common diseases of people living in extreme poverty and are the subject of this review. The development of NTD vaccines, including those for hookworm infection, schistosomiasis, leishmaniasis, and Chagas disease, is being led by nonprofit product development partnerships (PDPs) working in consortia of academic and industrial partners, including vaccine manufacturers in developing countries. NTD vaccines face unique challenges with respect to their product development and manufacture, as well as their preclinical and clinical testing. We emphasize global efforts to accelerate the development of NTD vaccines and some of the hurdles to ensuring their availability to the world's poorest people.
authors.affiliation: Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030; email: strych@bcm.edu.|Department of Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030; email: hotez@bcm.edu , bottazzi@bcm.edu.|Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Houston, Texas 77030.|Sabin Vaccine Institute, Washington, DC and Houston, Texas.|Baker Institute, Rice University, Houston, Texas 77030.|Department of Biology, Baylor University, Waco, Texas 76706.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hotez
authors.affiliation: Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030; email: strych@bcm.edu.|Department of Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030; email: hotez@bcm.edu , bottazzi@bcm.edu.|Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Houston, Texas 77030.|Sabin Vaccine Institute, Washington, DC and Houston, Texas.|Department of Biology, Baylor University, Waco, Texas 76706.
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Bottazzi
authors.affiliation: Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030; email: strych@bcm.edu.|Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Houston, Texas 77030.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Strych
mesh_terms: D014355:Chagas Disease / Q000517:prevention & control; D003299:Cooperative Behavior; D003906:Developing Countries; D055808:Drug Discovery; D004345:Drug Industry; D006040:Goals; D015658:HIV Infections / Q000517:prevention & control; D006725:Hookworm Infections / Q000517:prevention & control; D006801:Humans; D007896:Leishmaniasis / Q000517:prevention & control; D008288:Malaria / Q000517:prevention & control; D058069:Neglected Diseases / Q000517:prevention & control*; D009939:Organizations, Nonprofit / Q000191:economics; D011203:Poverty; D012552:Schistosomiasis / Q000517:prevention & control; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control; D014495:Universities; D014612:Vaccines / Q000191:economics / Q000600:supply & distribution; D014944:World Health Organization
chemical_list: D014612:Vaccines
keywords: diseases of poverty; global access; neglected tropical diseases; parasites; product development partnerships