title: Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors.
abstract: Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity.
authors.affiliation: Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria 21321, Egypt. sh.n.khattab@gmail.com.
authors.forename: Sherine N
authors.initials: SN
authors.lastname: Khattab
authors.affiliation: Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria 21321, Egypt. chemhosam1@yahoo.com.
authors.forename: Hosam H
authors.initials: HH
authors.lastname: Khalil
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt. adnbekhit@hotmail.com.
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Bekhit
authors.affiliation: Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria 21321, Egypt. mohamedmokbel80@gmail.com.
authors.forename: Mohamed Mokbel Abd
authors.initials: MM
authors.lastname: El-Rahman
authors.affiliation: Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria 21321, Egypt. aymanel_faham@hotmail.com.|Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. aymanel_faham@hotmail.com.
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Faham
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. albericio@irbbarcelona.org.|Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. albericio@irbbarcelona.org.|School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa. albericio@irbbarcelona.org.|Institute for Research in Biomedicine and CIBER-BBN, Barcelona 08028, Spain. albericio@irbbarcelona.org.|Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain. albericio@irbbarcelona.org.
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D003010:Clorgyline / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009025:Morpholines / Q000737:chemistry; D010880:Piperidines / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D014227:Triazines / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D008996:Monoamine Oxidase Inhibitors; D009025:Morpholines; D010880:Piperidines; D014227:Triazines; C032727:piperidine; D003010:Clorgyline
keywords: 1,3,5-triazine derivatives; amino acids; monoamine oxidase; morpholine; piperidine