title: Recent Advances of Radionuclide-Based Molecular Imaging of Atherosclerosis.
abstract: Atherosclerosis is a systemic disease characterized by the development of multifocal plaque lesions within vessel walls and extending into the vascular lumen. The disease takes decades to develop symptomatic lesions, affording opportunities for accurate detection of plaque progression, analysis of risk factors responsible for clinical events, and planning personalized treatment. Of the available molecular imaging modalities, radionuclidebased imaging strategies have been favored due to their sensitivity, quantitative detection and pathways for translational research. This review summarizes recent advances of radiolabeled small molecules, peptides, antibodies and nanoparticles for atherosclerotic plaque imaging during disease progression.
authors.forename: Soraya M
authors.initials: SM
authors.lastname: Kazuma
authors.forename: Deborah
authors.initials: D
authors.lastname: Sultan
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Lisa
authors.initials: L
authors.lastname: Detering
authors.forename: Meng
authors.initials: M
authors.lastname: You
authors.forename: Hannah P
authors.initials: HP
authors.lastname: Luehmann
authors.forename: Dulcineia S P
authors.initials: DS
authors.lastname: Abdalla
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, 63110, United States. liuyo@mir.wustl.edu.
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D057054:Molecular Imaging / Q000379:methods; D053758:Nanoparticles / Q000008:administration & dosage; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D012307:Risk Factors; D012680:Sensitivity and Specificity; D057170:Translational Research, Biomedical