title: Gastrointestinal hormone secretion in women with polycystic ovary syndrome: an observational study.
abstract: OBJECTIVE
  Is the secretion of gastrointestinal hormones impaired in patients with polycystic ovary syndrome (PCOS)?
  
  
  CONCLUSIONS
  Gastrointestinal hormone levels were abnormal in patients with PCOS.
  
  
  BACKGROUND
  The hormones glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) are both involved in signaling satiety. Secretion of GLP-1 and PYY in response to nutrients in the small intestine plays an important role in energy metabolism. Most PCOS patients are overweight or obese, which suggests dysregulation of appetite.
  
  
  METHODS
  In order to evaluate levels of gastrointestinal hormones in PCOS, a cohort study was undertaken, involving 30 PCOS patients and 29 BMI-matched healthy women recruited from Shanghai Renji Hospital between 1 March 2013 and 30 May 2014.
  
  
  METHODS
  After an overnight fast, all participants underwent an oral glucose tolerance test. Blood was sampled frequently for measurement of blood glucose and plasma insulin, total GLP-1 and PYY concentrations.
  
  
  RESULTS
  Fasting and postprandial insulin levels were significantly higher in patients with PCOS compared with the healthy controls (P < 0.05). Fasting and postprandial GLP-1 (t = 0 and 30 min; mean ± SEM) were also higher in PCOS group (17.5 ± 1.07 pM versus 14.1 ± 1.16 pM, P < 0.05; 29.7 ± 2.39 pM versus 22.8 ± 2.09 pM, P < 0.05). However, there were no differences in plasma PYY between patients with PCOS and healthy controls either fasting or postprandially. PYY levels were lower in obese PCOS patients than in lean PCOS patients (P < 0.05).
  
  
  CONCLUSIONS
  The study involved a small number of subjects with PCOS, and examined hormone responses to oral glucose rather than a physiological meal.
  
  
  CONCLUSIONS
  Deficient secretion of GLP-1 and PYY does not contribute to excessive food intake in the pathophysiology of PCOS.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160 Pujian Road, Pudong New Area, Shanghai, China.
authors.forename: Tzuchun
authors.initials: T
authors.lastname: Lin
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160 Pujian Road, Pudong New Area, Shanghai, China.
authors.forename: Shengxian
authors.initials: S
authors.lastname: Li
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160 Pujian Road, Pudong New Area, Shanghai, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xu
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160 Pujian Road, Pudong New Area, Shanghai, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160 Pujian Road, Pudong New Area, Shanghai, China.
authors.forename: Rilu
authors.initials: R
authors.lastname: Feng
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160 Pujian Road, Pudong New Area, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 160 Pujian Road, Pudong New Area, Shanghai, China cherry1996@live.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
mesh_terms: D000328:Adult; D004151:Dipeptides / Q000097:blood*; D005260:Female; D005768:Gastrointestinal Hormones / Q000097:blood*; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*
chemical_list: D004151:Dipeptides; D005768:Gastrointestinal Hormones; D007328:Insulin; C042696:tyrosyltyrosine; D052216:Glucagon-Like Peptide 1
keywords: GLP-1; PYY; body weight; energy intake; polycystic ovary syndrome