title: The prognostic value of first-trimester cystatin C levels for gestational complications.
abstract: OBJECTIVE
  This study is designed to evaluate predictive value of first-trimester cystatin C levels for long-term pregnancy complications.
  
  
  METHODS
  The cross-sectional study population consisted of patients who admitted to outpatient clinic of a Maternity Hospital between September 2013 and December 2014. Among the 203 participants who accepted to participate in the study, 174 subjects who continued antenatal follow-up in the same clinic were included in the final analyses. Cystatin C, blood urea nitrogen, Creatinine levels and estimated glomerular filtration rates were evaluated in the first-trimester routine antenatal visit. Mode of delivery and gestational complications were noted.
  
  
  RESULTS
  First-trimester cystatin C levels were significantly higher in cases complicated with preterm delivery and premature rupture of membrane (PROM) compared to uncomplicated ones (0.58±0.07 vs. 0.55±0.07, P=0.041, and 0.58±0.07 vs. 0.55±0.07, P=0.036). With a cutoff value of 0.505 mg/L, sensitivity of cystatin C for preterm delivery and PROM was 91.9% and specificity was 27.7% with a negative predictive value of 92.3% and a positive predictive value of 26.6%.
  
  
  CONCLUSIONS
  Detection of cystatin C levels in the first trimester of pregnancy for the prediction of preterm/PROM seems as a promising preliminary data. The relatively higher first-trimester cystatin C levels in complicated pregnancies are conspicuous. The results imply that in pregnancy cystatin C might be more than a marker for renal function.
authors.forename: Aslı Yarcı
authors.initials: AY
authors.lastname: Gursoy
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Tasci
authors.forename: Hatice
authors.initials: H
authors.lastname: Celik
authors.forename: Gamze S
authors.initials: GS
authors.lastname: Caglar
authors.forename: Mine
authors.initials: M
authors.lastname: Kiseli
authors.forename: Tuba
authors.initials: T
authors.lastname: Candar
authors.forename: Selda
authors.initials: S
authors.lastname: Demirtas
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood; D047928:Premature Birth / Q000097:blood; D011379:Prognosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C