title: INHIBIT-inspired two-output DNA logic gates based on surface-enhanced Raman scattering.
abstract: Herein, we presented a novel logic gate based on an INHIBITION gate that performs parallel readouts. Logic gates performing INHIBITION and YES/OR were constructed using surface-enhanced Raman scattering as optical outputs for the first time. The strategy allowed for simultaneous reading of outputs in one tube. The applicability of this strategy has been successfully exemplified in the construction of half-adder using the two-output logic gates as reporting gates. This reporting strategy provides additional design flexibility for dynamic DNA devices.
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (P.R. China).
authors.forename: Zitong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (P.R. China).
authors.forename: Boran
authors.initials: B
authors.lastname: Dong
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (P.R. China). zhouxd@whu.edu.cn.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (P.R. China).
authors.forename: Aiguo
authors.initials: A
authors.lastname: Shen
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (P.R. China). jmhu@whu.edu.cn.
authors.forename: Jiming
authors.initials: J
authors.lastname: Hu
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D004247:DNA
keywords: DNA; analytical methods; half-adder; logic gates; surface-enhanced Raman scattering