title: Childhood type 1 diabetes may increase the risk of atopic dermatitis.
abstract: BACKGROUND
  Epidemiological investigations have examined the association between type 1 diabetes mellitus (T1DM) and atopic disease, but have obtained conflicting results.
  
  
  OBJECTIVE
  To analyse the association between T1DM and atopic dermatitis (AD) in a population-based, retrospective cohort study that investigated the hypothesis that childhood T1DM is a risk factor for subsequent AD.
  
  
  METHODS
  From claims data of the National Health Insurance programme of Taiwan, we identified 3386 patients with T1DM newly diagnosed from 1998 to 2011 and 12 725 randomly selected controls without T1DM. These were frequency matched by age, sex and year of diagnosis. Both cohorts were followed up until the end of 2011 to evaluate the AD risk. We used Cox proportional hazards regression models to analyse the risk of AD.
  
  
  RESULTS
  The overall incidence rate of AD was 1·40-fold (significantly) higher in the T1DM cohort than in the non-T1DM cohort (3·31 vs. 2·35 per 1000 person years). After adjustment for potential risk factors, the overall risk of AD remained higher in the T1DM cohort [adjusted hazard ratio (HR) 1·76, 95% confidence interval (CI) 1·29-2·39] than in those without T1DM. Compared with the non-T1DM cohort, the patients with T1DM with more emergency room visits (adjusted HR 30·1, 95% CI 18·7-48·5) or hospitalizations (adjusted HR 70·3, 95% CI 45·6-114·5) had a higher risk of subsequent AD.
  
  
  CONCLUSIONS
  This nationwide, retrospective cohort study demonstrates that childhood T1DM may increase the risk of AD.
authors.affiliation: Children's Hospital, China Medical University Hospital, Taichung, Taiwan.|Department of Biomedical Imaging and Radiological Science, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan.
authors.forename: C-H
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Children's Hospital, China Medical University Hospital, Taichung, Taiwan.|College of Medicine, China Medical University Hospital, Taichung, Taiwan.
authors.forename: C-C
authors.initials: CC
authors.lastname: Wei
authors.affiliation: College of Medicine, China Medical University Hospital, Taichung, Taiwan.|Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
authors.forename: C-L
authors.initials: CL
authors.lastname: Lin
authors.affiliation: College of Medicine, China Medical University Hospital, Taichung, Taiwan.|Department of Radiology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: W-C
authors.initials: WC
authors.lastname: Lin
authors.affiliation: Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan.|Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
authors.forename: C-H
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012923:Social Class; D013624:Taiwan / Q000453:epidemiology