title: Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options.
abstract: Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI may be indistinguishable from those of other causes of liver injury, such as acute viral hepatitis. In this review article, we provide an update on causative agents, clinical features, pathogenesis, diagnosis modalities, and outcomes of DILI. In addition, we review results of recently reported genetic studies and updates on pharmacological and invasive treatments.
authors.affiliation: Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Tawfik
authors.initials: T
authors.lastname: Khoury
authors.affiliation: Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Ayman Abu
authors.initials: AA
authors.lastname: Rmeileh
authors.affiliation: Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Liron
authors.initials: L
authors.lastname: Yosha
authors.affiliation: Department of Gastroenterology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Ariel A
authors.initials: AA
authors.lastname: Benson
authors.affiliation: Department of Gastroenterology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Saleh
authors.initials: S
authors.lastname: Daher
authors.affiliation: Center for Advanced Endoscopy, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Meir
authors.initials: M
authors.lastname: Mizrahi
keywords: DILI; Hepatotoxicity; Treatment