title: Neuropilin-1 (NRP-1) and Magnetic Nanoparticles, a Potential Combination for Diagnosis and Therapy of Gliomas.
abstract: In this review, Neuropilin-1 (NRP-1) has been focused as a novel molecular target for potential treatment of gliomas. The properties of NRP-1 were described briefly. The role of NRP-1 in gliomas was explored in details, including relationships of NRP-1 expression and glioma prognosis, Sema3A-NRP-1 signaling in gliomas, NRP-1 signaling and VEGF/VEGFR, PlGF, TGF-β, PDGF, LD22-4 of FGF2, autocrine of HGF/SF, p130Cas tyrosine phosphorylation and integrin-associated tumor microenvironment in gliomas, NRP-1 intracellular trafficking, NRP-1 and glioma stem-like cells, as well as magnetic nanoparticles related to targeting gliomas. NRP-1, a multifunctional-receptors protein, would mediate diverse cellular signaling pathways in gliomas, and might potentially act as a novel therapeutic target. In future, magnetic nanoparticles coated with NRP-1 may play a vital role on diagnosis and therapy of gliomas.
authors.affiliation: Department of Neurosurgery, Zhongda Hospital Southeast University, 87 Dingjiaqiao, Gulou District, Nanjing, 210009, China. neuro_clk@hotmail.com.
authors.forename: Lukui
authors.initials: L
authors.lastname: Chen
authors.forename: Guilong
authors.initials: G
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Rong
authors.initials: R
authors.lastname: Qiu
authors.forename: Ahsan Ali
authors.initials: AA
authors.lastname: Khan
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D005910:Glioma / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D039942:Neuropilin-1 / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D058185:Magnetite Nanoparticles; D039942:Neuropilin-1