title: Plasma Adiponectin Levels in Acute Liver Failure Patients Treated with Plasma Filtration with Dialysis and Plasma Exchange.
abstract: Plasma filtration with dialysis (PDF) is a blood purification therapy in which simple plasma exchange (PE) is performed using a selective membrane plasma separator while the dialysate flows outside of the hollow fibers. Improvement of hypoadiponectinemia is considered to be a useful therapeutic approach for ameliorating fatal conditions including cardio-metabolic and infectious disease. We investigated the effects of PDF in comparison to PE in terms of plasma adiponectin (APN) changes in patients with acute liver failure. Seventeen patients with liver failure were studied; PDF was performed 55 times and PE 14 times. Plasma APN levels increased significantly after PDF, while decreasing significantly after PE. PDF appears to be among the most useful blood purification therapies in acute liver failure cases in terms of increasing APN levels.
authors.affiliation: Department of Surgery, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Department of Emergency and Critical Care Medicine, Akita University School of Medicine, Akita, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakae
authors.affiliation: Department of Gastroenterological Surgery, Shinkoga Hospital, Fukuoka, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Uji
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Department of Surgery, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Tani
authors.affiliation: Department of Critical and Intensive Care Medicine, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Eguchi
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D057186:Comparative Effectiveness Research; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D007564:Japan; D017114:Liver Failure, Acute / Q000097:blood / Q000209:etiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange / Q000379:methods*; D010956:Plasmapheresis / Q000379:methods*; D011446:Prospective Studies; D006435:Renal Dialysis / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D052242:Adiponectin
keywords: Acute liver failure; Adiponectin; Artificial liver support systems; Plasma exchange; Plasma filtration with dialysis