title: Development of albumin-based nanoparticles for the delivery of abacavir.
abstract: The study was designed to prepare and evaluate albumin nanoparticles containing antiviral drug abacavir sulphate. Various batches of albumin nanoparticles containing abacavir sulphate were prepared by desolvation method. The abacavir loaded particles were characterized for their yield, percentage of drug loading, surface morphology, particle size, surface charge, pattern of in vitro drug release and release mechanism studies. Drug loading ranged from 1.2 to 5.9%w/w. The mean particle size and the surface charge were 418.2nm and -40.8mV respectively. The in vitro drug release varied between 38.73 and 51.36%w/w for 24h. The n value for Korsmeyer-Peppas was 0.425 indicating Fickian type drug release. The preliminary findings indicated that albumin nanoparticles of abacavir can be prepared by desolvation method with good yield, high drug loading and sustained release.
authors.affiliation: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India. Electronic address: antrilparavai@gmail.com.
authors.forename: Barnabas
authors.initials: B
authors.lastname: Wilson
authors.affiliation: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
authors.forename: Latishkumar
authors.initials: L
authors.lastname: Paladugu
authors.affiliation: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
authors.forename: S R Brahmani
authors.initials: SR
authors.lastname: Priyadarshini
authors.affiliation: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
authors.forename: J Josephine Leno
authors.initials: JJ
authors.lastname: Jenita
mesh_terms: D000418:Albumins / Q000737:chemistry*; D000818:Animals; D002417:Cattle; D002626:Chemistry, Pharmaceutical; D015224:Dideoxynucleosides / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage*; D000099227:Abacavir
chemical_list: D000418:Albumins; D015224:Dideoxynucleosides; D004337:Drug Carriers; D018894:Reverse Transcriptase Inhibitors; D000099227:Abacavir
keywords: Abacavir; Albumin nanoparticles; HIV/AIDS treatment