title: Dynamics of p53 and Wnt cross talk.
abstract: We present the mechanism of interaction of Wnt network module, which is responsible for periodic somitogenesis, with p53 regulatory network, which is one of the main regulators of various cellular functions, and switching of various oscillating states by investigating p53-Wnt model. The variation in Nutlin concentration in p53 regulating network drives the Wnt network module to different states, stabilized, damped and sustain oscillation states, and even to cycle arrest. Similarly, the change in Axin2 concentration in Wnt could able to modulate the p53 dynamics at these states. We then solve the set of coupled ordinary differential equations of the model using quasi steady state approximation. We, further, demonstrate the change of p53 and GSK3 interaction rate, due to hypothetical catalytic reaction or external stimuli, can able to regulate the dynamics of the two network modules, and even can control their dynamics to protect the system from cycle arrest (apoptosis).
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India; School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
authors.forename: Md
authors.initials: M
authors.lastname: Zubbair Malik
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India; School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
authors.forename: Shahnawaz
authors.initials: S
authors.lastname: Ali
authors.affiliation: College of Applied Medical Sciences, University of Hail, P.O. Box 2440, Hail, Kingdom of Saudi Arabia; School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
authors.forename: Md Jahoor
authors.initials: MJ
authors.lastname: Alam
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
authors.forename: Romana
authors.initials: R
authors.lastname: Ishrat
authors.affiliation: School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address: brojen@jnu.ac.in.
authors.forename: R K
authors.initials: RK
authors.lastname: Brojen Singh
mesh_terms: D017209:Apoptosis; D060466:Axin Protein / Q000378:metabolism; D053263:Gene Regulatory Networks / Q000235:genetics; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000378:metabolism; D008954:Models, Biological; D010879:Piperazines / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000235:genetics
chemical_list: C491761:AXIN2 protein, human; D060466:Axin Protein; D007093:Imidazoles; D010879:Piperazines; D016159:Tumor Suppressor Protein p53; C482203:nutlin 1; D038362:Glycogen Synthase Kinase 3
keywords: Fixed point oscillations; Nutlin; Sustain oscillations; Wnt; p53 activation