title: Phenolics from Caesalpinia ferrea Mart.: antioxidant, cytotoxic and hypolipidemic activity.
abstract: Nine phenolics were isolated from the aqueous ethanol extract of the leaves of Caesalpinia ferrea. The isolates were characterized for the first time from that plant. The structures of all isolates (1-9) were elucidated by conventional methods, spectroscopic analysis, including 1 D and 2D NMR, and by HR-ESIMS as well. The antioxidant capacities using the ORAC method and the cytotoxic activity using the neutral red assay (NRU) for that extract and three major isolates have been evaluated. In addition, the hypolipidemic activity (in vitro and in vivo) of the extract has been assessed.
authors.forename: M A
authors.initials: MA
authors.lastname: Nawwar
authors.forename: S A
authors.initials: SA
authors.lastname: Hussein
authors.forename: A M
authors.initials: AM
authors.lastname: El-Mousallami
authors.forename: A N
authors.initials: AN
authors.lastname: Hashim
authors.forename: M A
authors.initials: MA
authors.lastname: Mousa
authors.forename: M H
authors.initials: MH
authors.lastname: Hetta
authors.forename: M A
authors.initials: MA
authors.lastname: Hamed
authors.forename: V
authors.initials: V
authors.lastname: Werner
authors.forename: A
authors.initials: A
authors.lastname: Becker
authors.forename: B
authors.initials: B
authors.lastname: Haertel
authors.forename: U
authors.initials: U
authors.lastname: Lindequist
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D029911:Caesalpinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000097:blood; D016166:Free Radical Scavengers / Q000494:pharmacology; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D016166:Free Radical Scavengers; D000960:Hypolipidemic Agents; D010636:Phenols; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D002784:Cholesterol