title: The changing epidemiology of Acinetobacter spp. producing OXA carbapenemases causing bloodstream infections in Brazil: a BrasNet report.
abstract: We evaluated the epidemiology of Acinetobacter spp. recovered from patients diagnosed with bloodstream infections in 9 tertiary hospitals located in all Brazilian geographic regions between April and August 2014. Although OXA-23-producing Acinetobacter baumannii clones were disseminated in most hospitals, it was observed for the first time the spread of OXA-72 among clonally related A. baumannii isolated from distinct hospitals. Interestingly, Acinetobacter pittii was the most frequent species found in a Northern region hospital. Contrasting with the multisusceptible profile displayed by A. pittii isolates, the tetracyclines and polymyxins were the only antimicrobials active against all A. baumannii isolates.
authors.affiliation: Laboratório Nacional de Computação Científica-LNCC/MCTI, Petrópolis, RJ, Brazil. Electronic address: atrv@lncc.br.
authors.forename: Ana Tereza R
authors.initials: AT
authors.lastname: Vasconcelos
authors.affiliation: Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, RS, Brazil.
authors.forename: Afonso L
authors.initials: AL
authors.lastname: Barth
authors.affiliation: Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, RS, Brazil.
authors.forename: Alexandre P
authors.initials: AP
authors.lastname: Zavascki
authors.affiliation: Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, SP, Brazil.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Gales
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo-USP, LIM 03-Departamento de Patologia, LIM-54-Instituto de Medicina Tropical/USP, São Paulo, SP, Brazil.
authors.forename: Anna S
authors.initials: AS
authors.lastname: Levin
authors.affiliation: Departamento de Medicina, Universidade de Taubaté-UNITAU, Taubaté, SP, Brazil.
authors.forename: Bianca R
authors.initials: BR
authors.lastname: Lucarevschi
authors.affiliation: Fundação Santa Casa de Misericórdia do Pará/UFPA and Instituto Evandro Chagas/SVS/MS, Belém, PA, Brazil.
authors.forename: Blenda G
authors.initials: BG
authors.lastname: Cabral
authors.affiliation: Fundação Santa Casa de Misericórdia do Pará/UFPA and Instituto Evandro Chagas/SVS/MS, Belém, PA, Brazil.
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Brasiliense
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo-USP, LIM 03-Departamento de Patologia, LIM-54-Instituto de Medicina Tropical/USP, São Paulo, SP, Brazil.
authors.forename: Flavia
authors.initials: F
authors.lastname: Rossi
authors.affiliation: Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, SP, Brazil.
authors.forename: Guilherme H C
authors.initials: GH
authors.lastname: Furtado
authors.affiliation: Fundação Santa Casa de Misericórdia do Pará/UFPA and Instituto Evandro Chagas/SVS/MS, Belém, PA, Brazil.
authors.forename: Irna Carla R S
authors.initials: IC
authors.lastname: Carneiro
authors.affiliation: Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, SP, Brazil.
authors.forename: Juliana O
authors.initials: JO
authors.lastname: da Silva
authors.affiliation: Hospital de Base, Brasília, DF, Brazil.
authors.forename: Julival
authors.initials: J
authors.lastname: Ribeiro
authors.affiliation: Fundação Santa Casa de Misericórdia do Pará/UFPA and Instituto Evandro Chagas/SVS/MS, Belém, PA, Brazil.
authors.forename: Karla V B
authors.initials: KV
authors.lastname: Lima
authors.affiliation: Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, SP, Brazil; Hospital Israelita Albert Einstein-HIAE and Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil.
authors.forename: Luci
authors.initials: L
authors.lastname: Correa
authors.affiliation: Centro de Patologia Clinica/Universidade Federal do Rio Grande do Norte-UFRN, Natal, RN, Brazil.
authors.forename: Maria H
authors.initials: MH
authors.lastname: Britto
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo-USP, LIM 03-Departamento de Patologia, LIM-54-Instituto de Medicina Tropical/USP, São Paulo, SP, Brazil.
authors.forename: Mariama T
authors.initials: MT
authors.lastname: Silva
authors.affiliation: Fundação Santa Casa de Misericórdia do Pará/UFPA and Instituto Evandro Chagas/SVS/MS, Belém, PA, Brazil.
authors.forename: Marília L
authors.initials: ML
authors.lastname: da Conceição
authors.affiliation: Departamento de Medicina, Universidade de Taubaté-UNITAU, Taubaté, SP, Brazil.
authors.forename: Marina
authors.initials: M
authors.lastname: Moreira
authors.affiliation: Hospital Israelita Albert Einstein-HIAE and Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil.
authors.forename: Marinês D V
authors.initials: MD
authors.lastname: Martino
authors.affiliation: Centro de Patologia Clinica/Universidade Federal do Rio Grande do Norte-UFRN, Natal, RN, Brazil.
authors.forename: Marise R
authors.initials: MR
authors.lastname: de Freitas
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo-USP, LIM 03-Departamento de Patologia, LIM-54-Instituto de Medicina Tropical/USP, São Paulo, SP, Brazil.
authors.forename: Maura S
authors.initials: MS
authors.lastname: Oliveira
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo-USP, LIM 03-Departamento de Patologia, LIM-54-Instituto de Medicina Tropical/USP, São Paulo, SP, Brazil.
authors.forename: Mirian F
authors.initials: MF
authors.lastname: Dalben
authors.affiliation: Hospital de Base, Brasília, DF, Brazil.
authors.forename: Ricardo D
authors.initials: RD
authors.lastname: Guzman
authors.affiliation: Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, SP, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cayô
authors.affiliation: Centro de Patologia Clinica/Universidade Federal do Rio Grande do Norte-UFRN, Natal, RN, Brazil.
authors.forename: Rosângela
authors.initials: R
authors.lastname: Morais
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo-USP, LIM 03-Departamento de Patologia, LIM-54-Instituto de Medicina Tropical/USP, São Paulo, SP, Brazil.
authors.forename: Sânia A
authors.initials: SA
authors.lastname: Santos
authors.affiliation: Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, SP, Brazil.
authors.forename: Willames M B S
authors.initials: WM
authors.lastname: Martins
mesh_terms: D000150:Acinetobacter / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D016133:Polymerase Chain Reaction; D062606:Tertiary Care Centers; D055815:Young Adult; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Acinetobacter spp; Bloodstream infections; Molecular epidemiology; OXA carbapenemase