title: Improved outcomes after low-concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis.
abstract: OBJECTIVE
  We aimed to evaluate the effectiveness of low-concentration hypochlorous acid (HOCl) nasal irrigation compared to isotonic normal saline for pediatric chronic rhinosinusitis.
  
  
  METHODS
  This was a randomized, prospective, active-controlled study.
  
  
  METHODS
  This study investigated the effectiveness of 4 weeks of low-concentration hypochlorous irrigation by analyzing five categorized subjective symptoms and x-ray findings in pediatric patients with rhinosinusitis. Thirty-seven patients were enrolled, and 26 patients successfully completed the study.
  
  
  RESULTS
  Total symptom scores significantly improved with both HOCl and normal saline nasal irrigation, but there was no difference between the two groups. X-ray scores also improved in both groups; improvement was much greater in the HOCl group than the placebo group.
  
  
  CONCLUSIONS
  Nasal irrigation with HOCl is an effective adjuvant treatment compared to isotonic normal saline for pediatric sinusitis.
  
  
  METHODS
  1b.
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.|Airway Mucus Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Hyung-Ju
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Min
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Chung
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Do-Yang
authors.initials: DY
authors.lastname: Park
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Sang Yeob
authors.initials: SY
authors.lastname: Seong
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.|Airway Mucus Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Joo-Heon
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Jeung-Gweon
authors.initials: JG
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.|Airway Mucus Institute, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Chang-Hoon
authors.initials: CH
authors.lastname: Kim
mesh_terms: D002648:Child; D002908:Chronic Disease; D006801:Humans; D006997:Hypochlorous Acid / Q000008:administration & dosage*; D055556:Nasal Lavage; D011446:Prospective Studies; D012852:Sinusitis / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D006997:Hypochlorous Acid
keywords: Nasal irrigation; hypochlorous chloride; pediatric; sinusitis