title: Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies.
abstract: Glucagon-like peptide-1 (GLP-1) has shown to influence the oxidative stress status in a number of in vitro, in vivo and clinical studies. Well-known effects of GLP-1 including better glycemic control, decreased food intake, increased insulin release and increased insulin sensitivity may indirectly contribute to this phenomenon, but glucose-independent effects on ROS level, production and antioxidant capacity have been suggested to also play a role. The potential 'antioxidant' activity of GLP-1 along with other proposed glucose-independent modes of action related to ameliorating redox imbalance remains a controversial topic but could hold a therapeutic potential against micro- and macrovascular diabetic complications. This review discusses the presently available knowledge from experimental and clinical studies on the effects of GLP-1 on oxidative stress in diabetes and diabetes-related complications.
authors.forename: Karen Ekkelund
authors.initials: KE
authors.lastname: Petersen
authors.forename: Günaj
authors.initials: G
authors.lastname: Rakipovski
authors.forename: Kirsten
authors.initials: K
authors.lastname: Raun
authors.affiliation: Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870, Frederiksberg C, Denmark. jopl@sund.ku.dk.
authors.forename: Jens
authors.initials: J
authors.lastname: Lykkesfeldt
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D055317:Evidence-Based Practice; D000077270:Exenatide; D052216:Glucagon-Like Peptide 1 / Q000819:agonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism; D014688:Venoms / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D010455:Peptides; D017382:Reactive Oxygen Species; D014688:Venoms; D052216:Glucagon-Like Peptide 1; D000077270:Exenatide