title: Scrub typhus mimicking Parkinson's disease.
abstract: BACKGROUND
  Scrub typhus is a re-emerging infection in Sri Lanka. It often poses a diagnostic challenge and tends to present as a febrile illness of uncertain origin. Undiagnosed illness may progress to serious multi-systemic complications. Here we report a case of scrub typhus presenting with features of Parkinsonism.
  
  
  METHODS
  A 62-year-old previously healthy Sri Lankan native male from the Western province of Sri Lanka presented with high fever with malaise, myalgia and arthralgia for 17 days. On the 5th day of illness he developed intermittent resting tremor in his right arm and leg associated with stiffness, difficulty in carrying out normal work and difficulty in smiling. He denied similar previous episodes. There were no other associated neurological manifestations. Clinical examination revealed a high amplitude low frequency resting tremor in his right hand, a mask-like face and increased muscle tone limited to the right side with normal reflexes. The rest of the system examination was normal except for an eschar over the abdomen. His investigations revealed lymphocytic leukocytosis, high erythrocyte sedimentation rate and immunofluorescence assay-IgM and IgG against Orientia tsutsugamushi Karp antigen were positive with rising titers. With oral doxycycline and azithromycin his fever settled within 48 h and a complete recovery of Parkinson's features was observed within 2 weeks.
  
  
  CONCLUSIONS
  Doctors practicing in endemic regions should be familiar with delayed clinical manifestations of scrub typhus and should carefully look for an eschar in order to avoid delay in the diagnosis.
authors.affiliation: Colombo North Teaching Hospital, Ragama, Sri Lanka. ranjanp64@gmail.com.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Premaratna
authors.affiliation: Colombo North Teaching Hospital, Ragama, Sri Lanka. nuwancw84@gmail.com.
authors.forename: S H Nuwan Chamara
authors.initials: SH
authors.lastname: Wijayalath
authors.affiliation: Colombo North Teaching Hospital, Ragama, Sri Lanka. jkndmiththinda@gmail.com.
authors.forename: J K N Dhanushka
authors.initials: JK
authors.lastname: Miththinda
authors.affiliation: Colombo North Teaching Hospital, Ragama, Sri Lanka. wijesinghekbandara@gmail.com.
authors.forename: N K B K R G Wijesinghe
authors.initials: NK
authors.lastname: Bandara
authors.affiliation: Colombo North Teaching Hospital, Ragama, Sri Lanka. hjanakadesilva@gmail.com.
authors.forename: H Janaka
authors.initials: HJ
authors.lastname: de Silva
mesh_terms: D003937:Diagnosis, Differential; D005145:Face; D005843:Geography; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis*; D012612:Scrub Typhus / Q000175:diagnosis*