title: Targeting MicroRNAs in Prevention and Treatment of Neurodegenerative Disorders.
abstract: Preclinical Research microRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that are key regulators of gene expression. They act on wide range of targets by binding to mRNA via imperfect complementarity at 3' UTR. Evidence suggests that miRNAs regulate many biological processes including neuronal development, differentiation, and disease. Altered expression of several miRNAs has been reported in many neurodegenerative disorders (NDDs). Many miRNAs are altered in these diseases, but miRNA 15, miRNA 21, and miRNA 146a have been shown to play critical role in many neurodegenerative conditions. As these miRNAs regulate many genes, miRNA targeted approaches would allow concurrently targeting of multiple effectors of pathways that regulate disease progression. In this review, we describe the role of miRNAs in various NDDs and their potential as therapeutic tools in prevention and treatment of neurological conditions.
authors.affiliation: Department of Biochemistry, Panjab University, Chandigarh, 160014, India.
authors.forename: Smriti
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Department of Biochemistry, Panjab University, Chandigarh, 160014, India.
authors.forename: Savita
authors.initials: S
authors.lastname: Verma
authors.affiliation: Computational Biology Laboratory, National Agri-Food Biotechnology Institute, Mohali, Punjab, 160071, India.
authors.forename: Shrikant
authors.initials: S
authors.lastname: Mantri
authors.affiliation: Department of Anatomy & Cell Biology, Kansas University Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Berman
authors.affiliation: Department of Biochemistry, Panjab University, Chandigarh, 160014, India.
authors.forename: Rajat
authors.initials: R
authors.lastname: Sandhir
mesh_terms: D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000187:drug effects* / Q000235:genetics*; D058990:Molecular Targeted Therapy; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000235:genetics / Q000517:prevention & control*
chemical_list: D035683:MicroRNAs
keywords: brain; epigenetics; miRNAs; neurodegeneration; noncoding RNAs