title: A multifunctional metal-organic framework based tumor targeting drug delivery system for cancer therapy.
abstract: Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal-organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free "green" post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China. xz-zhang@whu.edu.cn hdeng@whu.edu.cn.
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Wang
authors.forename: Zhi-Yue
authors.initials: ZY
authors.lastname: Dong
authors.forename: Hong
authors.initials: H
authors.lastname: Cheng
authors.forename: Shuang-Shuang
authors.initials: SS
authors.lastname: Wan
authors.forename: Wei-Hai
authors.initials: WH
authors.lastname: Chen
authors.forename: Mei-Zhen
authors.initials: MZ
authors.lastname: Zou
authors.forename: Jia-Wei
authors.initials: JW
authors.lastname: Huo
authors.forename: He-Xiang
authors.initials: HX
authors.lastname: Deng
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D019556:COS Cells; D002522:Chlorocebus aethiops; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents