title: Dearomative Indole Bisfunctionalization via a Diastereoselective Palladium-Catalyzed Arylcyanation.
abstract: The first Pd-catalyzed dearomative indole bisfunctionalization via a diastereoselective arylcyanation is reported. This method facilitates the formation of diverse indoline scaffolds bearing congested stereocenters with high levels of diastereoselectivity. This also represents the first example of a cyanation mechanism involving a 2° benzylic Pd(II) intermediate.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto , Toronto, Canada , M5S 3H6.
authors.forename: David A
authors.initials: DA
authors.lastname: Petrone
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto , Toronto, Canada , M5S 3H6.
authors.forename: Andy
authors.initials: A
authors.lastname: Yen
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto , Toronto, Canada , M5S 3H6.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Zeidan
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto , Toronto, Canada , M5S 3H6.
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens