title: Regulation of germ cell function by SUMOylation.
abstract: Oogenesis and spermatogenesis are tightly regulated complex processes that are critical for fertility. Germ cells undergo meiosis to generate haploid cells necessary for reproduction. Errors in meiosis, including the generation of chromosomal abnormalities, can result in reproductive defects and infertility. Meiotic proteins are regulated by post-translational modifications including SUMOylation, the covalent attachment of small ubiquitin-like modifier (SUMO) proteins. Here, we review the role of SUMO proteins in controlling germ cell development and maturation based on recent findings from mouse models. Several studies have characterized the localization of SUMO proteins in male and female germ cells. However, a deeper understanding of how SUMOylation regulates proteins with essential roles in oogenesis and spermatogenesis will provide useful insight into the underlying mechanisms of germ cell development and fertility.
authors.affiliation: Graduate Program in Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.|Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Rodriguez
authors.affiliation: Graduate Program in Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. spangas@bcm.edu.|Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. spangas@bcm.edu.|Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA. spangas@bcm.edu.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Pangas
mesh_terms: D000818:Animals; D005260:Female; D005854:Germ Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D008297:Male; D008540:Meiosis; D051379:Mice; D009866:Oogenesis; D025841:Small Ubiquitin-Related Modifier Proteins / Q000032:analysis / Q000378:metabolism*; D013091:Spermatogenesis; D058207:Sumoylation
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins
keywords: Germ cell; Meiosis; Oocyte; SUMOylation; Spermatocyte