title: The effect of colchicine and disease severity on physical growth in children with familial Mediterranean fever.
abstract: This study aimed to investigate the effects of colchicine on growth parameters in familial Mediterranean fever (FMF) patients. Fifty-one (29 girls, 22 boys) FMF patients were enrolled in the study. All of the patients were in the prepubertal stage and had not received colchicine treatment before the study. Anthropometric measurements, demographic features, clinical findings at diagnosis and during periods of attacks of FMF, disease activity, frequency of exacerbations, colchicine dosage, and weight and height measurements were recorded at an interval of 6 months. Height, weight, and body mass index standard deviation scores and Z-scores were calculated. The mean height standard deviation score (HSDS) was significantly increased from -0.64 ± 1.20 to -0.26 ± 1.07 (p < 0.001), the mean weight standard deviation score (WSDS) was significantly increased from -0.60 ± 1.03 to -0.45 ± 0.98 (p = 0.008), and the mean body mass index standard deviation score was decreased from -0.33 ± 1.06 to -0.47 ± 0.98 (p = 0.128) at 1 year after colchicine treatment compared with before initiation of treatment. In patients who had no FMF attacks during colchicine treatment, height and weight were significantly increased at 1 year (HSDS: p < 0.001 WSDS: p = 0.002), but in patients who had recurrent attacks, height and weight did not change (HSDS: p = 0.051, WSDS: p = 0.816). Even when subclinical inflammation is present, preventing attacks of FMF with colchicine allows growth to continue. However, suppression of subclinical inflammation and control of attacks of FMF are required for weight gain.
authors.affiliation: Department of Pediatrics, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Tuba Çelen
authors.initials: TÇ
authors.lastname: Yoldaş
authors.affiliation: Department of Pediatric Nephrology and Rheumatology, Ankara Children's Hematology and Oncology Hospital, Karapınar mah. 1183. Cadde No: 3/7 Dikmen, Ankara, Turkey.
authors.forename: Nilgün
authors.initials: N
authors.lastname: Çakar
authors.affiliation: Department of Pediatric Nephrology and Rheumatology, Ankara Children's Hematology and Oncology Hospital, Karapınar mah. 1183. Cadde No: 3/7 Dikmen, Ankara, Turkey.
authors.forename: Özge
authors.initials: Ö
authors.lastname: Başaran
authors.affiliation: Department of Pediatric Nephrology and Rheumatology, Ankara Children's Hematology and Oncology Hospital, Karapınar mah. 1183. Cadde No: 3/7 Dikmen, Ankara, Turkey. banuacar@gmail.com.
authors.forename: Banu
authors.initials: B
authors.lastname: Acar
authors.affiliation: Department of Pediatric Nephrology and Rheumatology, Ankara Children's Hematology and Oncology Hospital, Karapınar mah. 1183. Cadde No: 3/7 Dikmen, Ankara, Turkey.
authors.forename: Nermin
authors.initials: N
authors.lastname: Uncu
authors.affiliation: Department of Pediatric Nephrology and Rheumatology, Ankara Children's Hematology and Oncology Hospital, Karapınar mah. 1183. Cadde No: 3/7 Dikmen, Ankara, Turkey.
authors.forename: F Şemsa
authors.initials: FŞ
authors.lastname: Çaycı
mesh_terms: D002648:Child; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D003078:Colchicine / Q000008:administration & dosage* / Q000009:adverse effects; D010505:Familial Mediterranean Fever / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000188:drug therapy*; D016014:Linear Models; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D014421:Turkey; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D003078:Colchicine
keywords: Children; Colchicine; Familial Mediterranean fever; Growth; Inflammation