title: Thiols-Induced Rapid Photoluminescent Enhancement of Glutathione-Capped Gold Nanoparticles for Intracellular Thiols Imaging Applications.
abstract: The rapid detection and imaging of intracellular thiols is of great importance during the occurrence and development of some chronic diseases. Here we demonstrate the rapid thiols-induced photoluminescence (PL) enhancement of the low luminescent glutathione (GSH) stabilized Au nanoparticles, AuGSH (low). The dynamic PL investigation reveals that the PL enhancement fits a first-order reaction model. The X-ray photoelectron spectroscopic and mass spectroscopic results indicate that AuGSH (low) are mainly comprised of "thiols-insufficient" Au species and the additional thiols can efficiently attach to the "unsaturated" surface of Au nanoparticles, accompanied by significant PL enhancement. The noncytotoxic AuGSH (low) probe can be successfully applied for imaging of intracellular thiols. Generally, this work illustrates the great prospects of facile-prepared AuGSH (low) as a candidate for thiols labeling and imaging.
authors.affiliation: State Key Laboratory of Bioelectronics, Southeast University , Nanjing 210096, People's Republic of China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Su
authors.affiliation: State Key Laboratory of Bioelectronics, Southeast University , Nanjing 210096, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Bioelectronics, Southeast University , Nanjing 210096, People's Republic of China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang
mesh_terms: D005978:Glutathione / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D049449:Luminescence; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D055668:Photochemical Processes; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D013438:Sulfhydryl Compounds; D006046:Gold; D005978:Glutathione