title: Single-Cell Analysis: The Differences That Kill.
abstract: Using single-cell RNA sequencing, Avraham et al. investigate how variability in macrophage response to infection is controlled by variability within the pathogen population. They find that heterogeneous expression of the Salmonella virulence factor PhoP and subsequent cell-wall modifications lead to the bimodal induction of the interferon-response in infected macrophages.
authors.affiliation: Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland; Institute for Molecular Engineering, University of Chicago, Chicago 60637, USA. Electronic address: tays@uchicago.edu.
authors.forename: Savaş
authors.initials: S
authors.lastname: Tay
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D008264:Macrophages / Q000276:immunology*; D012486:Salmonella typhimurium / Q000502:physiology*