title: The Dimension of Titania Nanotubes Influences Implant Success for Osteoclastogenesis and Osteogenesis Patients.
abstract: Implants that can inhibit osteoclastogenesis and enhance osteogenesis are desirable for osteoporosis patients. In this study, titania nanotube (Ti-NT) materials, having nanotube diameters of 30, 80, and 120 nm, were produced separately by anodization at 10, 40, and 60 V, respectively. The introduction of Ti-NTs to titanium substrates significantly reduced the formation and activity of osteoclasts on samples. With the enlargement of the nanotube diameter, the osteoclasts number, tartrate-resistant acid phosphatase staining and activity, and related gene expressions of osteoclasts were further reduced. Osteogenic ability was enhanced by increasing the nanotube diameter. Thus, larger-diameter nanotube implants, such as NT60, were better able to inhibit bone absorption and enhance bone formation to prevent implant loss and failure, especially for osteoporosis patients.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Biao
authors.initials: B
authors.lastname: Gao
authors.forename: Peng
authors.initials: P
authors.lastname: Tan
authors.forename: Baoguo
authors.initials: B
authors.lastname: Mi
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Cheng
authors.forename: Hui
authors.initials: H
authors.lastname: Liao
authors.forename: Kaifu
authors.initials: K
authors.lastname: Huo
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D043942:Nanotubes / Q000737:chemistry*; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects*; D010316:Particle Size; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C009495:titanium dioxide; D014025:Titanium