title: [Expression and correlation of IL-35 in gingival crevicular fluid and serum with chronic periodontitis].
abstract: OBJECTIVE
  To investigate the concentration of IL-35 in serum and gingival crevicular fluid (GCF) and the correlation between IL-35 and periodontal clinical parameters, and explore the possible role of IL-35 in chronic periodontitis (CP).
  
  
  METHODS
  Twenty patients with moderate or severe chronic periodontitis were selected as experimental group and 20 healthy people were included as control group. The patients' baseline information, probing depth (PD) and clinical attachment level (CAL) were recorded. Their serum and GCF were collected and then the concentration of IL-35 in GCF and serum were detected by ELISA. SPSS19.0 software package was used for statistical analysis.
  
  
  RESULTS
  The concentration of IL-35 in GCF and serum of chronic periodontitis were significantly higher than the control group (P<0.001). There was significant negative correlation between IL-35 and clinical parameters.
  
  
  CONCLUSIONS
  Chronic periodontitis may increase the concentration of IL-35 in serum and GCF; IL-35 level is negatively correlated with periodontitis.
authors.affiliation: Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China. E-mail:echoliu0606@gmail.com.
authors.forename: Di-xin
authors.initials: DX
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Jin
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Lin
mesh_terms: D055113:Chronic Periodontitis / Q000453:epidemiology / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D006801:Humans; D007378:Interleukins / Q000378:metabolism*
chemical_list: D007378:Interleukins; C532417:interleukin-35, human