title: Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico.
abstract: Metabolic syndrome (MetS) is a combination of metabolic disorders associated with an increased risk for cardiovascular disease (CVD). Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, LPL and CETP genes with MetS and its components. Four hundred and eighty women were analyzed, anthropometric features and biochemical profiles were evaluated, and genotyping was performed by real-time PCR. We found an association with elevated glucose levels (odds ratio (OR) = 2.9; p = 0.013) in carrying the AA genotype of rs1884051 in the ESR1 gene compared with the GG genotype, and the CC genotype of rs328 in the LPL gene was associated with MetS compared to the CG or GG genotype (OR = 2.8; p = 0.04). Moreover, the GA genotype of rs708272 in the CETP gene is associated with MetS compared to the GG or AA genotype (OR = 1.8; p = 0.006). In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p < 0.001). In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features.
authors.affiliation: Laboratorio de Investigación en Epidemiología Clínica y Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico. jose9@hotmail.com.
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Cahua-Pablo
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades "Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal 06725, Mexico. mcruzl@yahoo.com.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Laboratorio de Investigación en Epidemiología Clínica y Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico. abymendezp@hotmail.com.
authors.forename: Abigail
authors.initials: A
authors.lastname: Méndez-Palacios
authors.affiliation: Laboratorio de Investigación en Epidemiología Clínica y Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico. diana_antunez84@hotmail.com.
authors.forename: Diana Lizzete
authors.initials: DL
authors.lastname: Antúnez-Ortiz
authors.affiliation: Laboratorio de Investigación en Epidemiología Clínica y Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico. avences_2003@yahoo.com.mx.
authors.forename: Amalia
authors.initials: A
authors.lastname: Vences-Velázquez
authors.affiliation: Laboratorio de Biomedicina Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico. luzdelcarmen14@gmail.com.
authors.forename: Luz
authors.initials: L
authors.lastname: del Carmen Alarcón-Romero
authors.affiliation: Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada. esteban.parra@utoronto.ca.
authors.forename: Esteban Juan
authors.initials: EJ
authors.lastname: Parra
authors.affiliation: Laboratorio de Investigación en Epidemiología Clínica y Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico. vatellof@gmail.com.
authors.forename: Vianet Argelia
authors.initials: VA
authors.lastname: Tello-Flores
authors.affiliation: Laboratorio de Biomedicina Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico. leyvamarco13@gmail.com.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Leyva-Vázquez
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades "Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal 06725, Mexico. adanval@gmail.com.
authors.forename: Adán
authors.initials: A
authors.lastname: Valladares-Salgado
authors.affiliation: Laboratorio de Investigación en Epidemiología Clínica y Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico. permac10@hotmail.com.
authors.forename: Claudia Paola
authors.initials: CP
authors.lastname: Pérez-Macedonio
authors.affiliation: Laboratorio de Investigación en Epidemiología Clínica y Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39089, Mexico. efloresa_2@hotmail.com.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Flores-Alfaro
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D003430:Cross-Sectional Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008071:Lipoprotein Lipase / Q000235:genetics*; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics*; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D053480:Cholesterol Ester Transfer Proteins; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D008071:Lipoprotein Lipase
keywords: ESR1 haplotype; LPL and CETP polymorphisms; metabolic syndrome