title: Correlation Between Serum Homocysteine Levels and Outcome of Patients with Severe Traumatic Brain Injury.
abstract: OBJECTIVE
  To examine the relationship between homocysteine (Hcy) plasma levels and the outcome of patients with traumatic brain injury (TBI).
  
  
  METHODS
  In a prospective case-control study, demographic, clinical, and Glasgow Coma Scale score data were collected. Outcome was evaluated according to the Glasgow Outcome Scale score at the time of discharge from the hospital and 6 months after hospitalization. Plasma levels of Hcy were measured using high-performance liquid chromatography. Computed tomography scan of the brain was performed within the first 24 hours of hospitalization.
  
  
  RESULTS
  The case group comprised 150 patients with TBI (men, 54.7%; mean age, 55.90 years ± 12.31), and a control group comprised 150 healthy individuals (men, 52%; mean age, 49.56 years ± 15.64) were studied. The mean ± SD plasma Hcy level in the TBI group (20.91 μmol/L ± 15.56) was significantly higher than plasma Hcy level in the control group (7.45 μmol/L ± 13.54, P = 0.000). There was a significant relationship between Hcy plasma levels and Glasgow Coma Scale score and computed tomography findings classified by the Marshall score. (P = 0.001 and P = 0.028, respectively). Also, there was a significant difference in mean Hcy plasma between patients who died as a result of TBI and patients who were still alive at the end of the study period according to Glasgow Outcome Scale score (P = 0.000 and P = 0.054, respectively).
  
  
  CONCLUSIONS
  There was a significant correlation in this study between plasma Hcy levels and severity of trauma and prognosis in patients with TBI.
authors.affiliation: Student Research Committee, School of Medicine, Ilam University of Medical Science, Ilam, Iran. Electronic address: asrahmani1991@yahoo.com.
authors.forename: Asghar
authors.initials: A
authors.lastname: Rahmani
authors.affiliation: Department of Neurosurgery, School of Medicine, Ilam University of Medical Science, Ilam, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Hatefi
authors.affiliation: Department of Emergency Medicine, School of Medicine, Esfahan University of Medical Science, Esfahan, Iran.
authors.forename: Masoud Moghadas
authors.initials: MM
authors.lastname: Dastjerdi
authors.affiliation: Department of Pharmacology, School of Pharmacology, International Shiraz University of Medical Science, Shiraz, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Zare
authors.affiliation: Department of Nursing and Midwifery, Medical and Surgical Nursing Education, Shahid Beheshti University of Medical Science, Tehran, Iran.
authors.forename: Asad
authors.initials: A
authors.lastname: Imani
authors.affiliation: General Medicine, Student Research Committee, School of Medicine, Ilam University of Medical Science, Ilam, Iran.
authors.forename: Davood
authors.initials: D
authors.lastname: Shirazi
mesh_terms: D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000097:blood* / Q000628:therapy; D016022:Case-Control Studies; D005260:Female; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D006710:Homocysteine
keywords: CT scan; Glasgow Coma Scale; Homocysteine; Outcome; Prognosis; Traumatic brain injury