title: Aggressive Blood Pressure Lowing Therapy in Patients with Acute Intracerebral Hemorrhage is Safe: A Systematic Review and Meta-analysis.
abstract: BACKGROUND
  The influence of blood pressure (BP) lowering on intracerebral hemorrhage (ICH) patients is unclear. To assess the safety and efficacy of aggressive antihypertensive therapies in acute ICH patients, we carried out a systematic review and meta-analysis.
  
  
  METHODS
  PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and VIP database up to July 2014 were searched. High-quality randomized controlled trials were included. Low-quality trials were excluded. Serious adverse events were defined as the primary outcome. The secondary outcomes were hematoma enlargement (HE) at 24 h after onset, mortality, and favorable clinical outcome at 90 days.
  
  
  RESULTS
  Four high-quality trials involving a total of 1427 patients met the inclusion criteria and were analyzed. Odds ratios (ORs) of primary outcome was 0.96 (95% confidence interval [CI ]: 0.82-1.13, P = 0.61). ORs of HE at 24 h after onset, mortality and favorable clinical outcome at 90 days were 0.91 (95% CI: 0.72-1.17, P = 0.47), 0.97 (95% CI: 0.79-1.20, P = 0.81), 1.13 (95% CI: 0.98-1.30, P = 0.09) respectively.
  
  
  CONCLUSIONS
  Aggressive BP management policies are safe and might have a potency of reducing HE and improving clinical outcome.
authors.forename: Chao
authors.initials: C
authors.lastname: Pan
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: You-Ping
authors.initials: YP
authors.lastname: Zhang
authors.forename: Miribanu
authors.initials: M
authors.lastname: Aimaiti
authors.forename: Hong
authors.initials: H
authors.lastname: Deng
authors.forename: Ying-Xing
authors.initials: YX
authors.lastname: Tang
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Sui-Qiang
authors.initials: SQ
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
authors.forename: Zhou-Ping
authors.initials: ZP
authors.lastname: Tang
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D006406:Hematoma / Q000188:drug therapy; D006801:Humans; D016032:Randomized Controlled Trials as Topic
chemical_list: D000959:Antihypertensive Agents