title: A Quasi-Experimental Study Analyzing the Effectiveness of Portable High-Efficiency Particulate Absorption Filters in Preventing Infections in Hematology Patients during Construction.
abstract: OBJECTIVE
  The increased risk of infection for patients caused by construction and renovation near hematology inpatient clinics is a major concern. The use of high-efficiency particulate absorption (HEPA) filters can reduce the risk of infection. However, there is no standard protocol indicating the use of HEPA filters for patients with hematological malignancies, except for those who have undergone allogeneic hematopoietic stem cell transplantation. This quasi-experimental study was designed to measure the efficacy of HEPA filters in preventing infections during construction.
  
  
  METHODS
  Portable HEPA filters were placed in the rooms of patients undergoing treatment for hematological malignancies because of large-scale construction taking place near the hematology clinic. The rates of infection during the 6 months before and after the installation of the portable HEPA filters were compared. A total of 413 patients were treated during this 1-year period.
  
  
  RESULTS
  There were no significant differences in the antifungal prophylaxis and treatment regimens between the groups. The rates of infections, clinically documented infections, and invasive fungal infections decreased in all of the patients following the installation of the HEPA filters. When analyzed separately, the rates of invasive fungal infections were similar before and after the installation of HEPA filters in patients who had no neutropenia or long neutropenia duration. HEPA filters were significantly protective against infection when installed in the rooms of patients with acute lymphocytic leukemia, patients who were undergoing consolidation treatment, and patients who were neutropenic for 1-14 days.
  
  
  CONCLUSIONS
  Despite the advent of construction and the summer season, during which environmental Aspergillus contamination is more prevalent, no patient or patient subgroup experienced an increase in fungal infections following the installation of HEPA filters. The protective effect of HEPA filters against infection was more pronounced in patients with acute lymphocytic leukemia, patients undergoing consolidation therapy, and patients with moderate neutropenia.
authors.affiliation: Ankara University Faculty of Medicine, Department of Hematology, Ankara, Turkey. Phone: +90 312 595 70 99 E-mail: kanbilimci@gmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Özen
authors.forename: Gülden
authors.initials: G
authors.lastname: Yılmaz
authors.forename: Belgin
authors.initials: B
authors.lastname: Coşkun
authors.forename: Pervin
authors.initials: P
authors.lastname: Topçuoğlu
authors.forename: Bengi
authors.initials: B
authors.lastname: Öztürk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gündüz
authors.forename: Erden
authors.initials: E
authors.lastname: Atilla
authors.forename: Önder
authors.initials: Ö
authors.lastname: Arslan
authors.forename: Muhit
authors.initials: M
authors.lastname: Özcan
authors.forename: Taner
authors.initials: T
authors.lastname: Demirer
authors.forename: Osman
authors.initials: O
authors.lastname: İlhan
authors.forename: Nahide
authors.initials: N
authors.lastname: Konuk
authors.forename: İsmail
authors.initials: İ
authors.lastname: Balık
authors.forename: Günhan
authors.initials: G
authors.lastname: Gürman
authors.forename: Hamdi
authors.initials: H
authors.lastname: Akan
mesh_terms: D065966:Absorption, Physicochemical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D061808:Air Filters / Q000191:economics; D000391:Air Microbiology; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D064147:Febrile Neutropenia / Q000150:complications; D005260:Female; D005335:Fever of Unknown Origin / Q000453:epidemiology / Q000209:etiology; D005374:Filtration / Q000191:economics / Q000295:instrumentation*; D019337:Hematologic Neoplasms / Q000150:complications* / Q000628:therapy; D017722:Hospital Charges; D006749:Hospital Design and Construction; D006801:Humans; D016867:Immunocompromised Host; D017053:Infection Control / Q000191:economics / Q000295:instrumentation / Q000379:methods*; D000072742:Invasive Fungal Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D052638:Particulate Matter / Q000009:adverse effects / Q000032:analysis; D010362:Patients' Rooms; D055815:Young Adult
chemical_list: D052638:Particulate Matter