title: Exosome-mediated microenvironment dysregulation in leukemia.
abstract: The hematopoietic stem cell (HSC) niche is composed of a complex set of stromal support cells that maintain HSCs and promote normal hematopoiesis. We now know that molecular changes within the hematopoietic niche contribute to leukemia development. Leukemia cells often reorganize the hematopoietic niche to promote and support their own survival and growth. Here we will summarize recent works that decipher the normal hematopoietic niche cellular components and describe how the leukemia-transformed niche contributes to hematological malignances. Finally, we will discuss recent publications that highlight a possible role for exosomes in the leukemia-induced niche reorganization. This article is part of a Special Issue entitled: Tumor Microenvironment Regulation of Cancer Cell Survival, Metastasis, Inflammation, and Immune Surveillance edited by Peter Ruvolo and Gregg L. Semenza.
authors.affiliation: Division of Hematopoietic Stem Cell and Leukemia Research of Beckman Research Institute, Gehr Family Center for Leukemia Research, Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA 91010, USA.
authors.forename: Bijender
authors.initials: B
authors.lastname: Kumar
authors.affiliation: Division of Hematopoietic Stem Cell and Leukemia Research of Beckman Research Institute, Gehr Family Center for Leukemia Research, Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA 91010, USA.
authors.forename: Mayra
authors.initials: M
authors.lastname: Garcia
authors.affiliation: Division of Hematopoietic Stem Cell and Leukemia Research of Beckman Research Institute, Gehr Family Center for Leukemia Research, Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA 91010, USA.
authors.forename: Jodi L
authors.initials: JL
authors.lastname: Murakami
authors.affiliation: Division of Hematopoietic Stem Cell and Leukemia Research of Beckman Research Institute, Gehr Family Center for Leukemia Research, Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA 91010, USA. Electronic address: chingchengchen@coh.org.
authors.forename: Ching-Cheng
authors.initials: CC
authors.lastname: Chen
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D055354:Exosomes / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D051881:Receptor, Notch1 / Q000378:metabolism; D055153:Stem Cell Niche; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D051881:Receptor, Notch1; D016212:Transforming Growth Factor beta
keywords: Exosomes; Hematopoietic stem cells; Leukemia cell; Niche