title: Prolidase-Associated Trace Elements (Mn, Zn, Co, and Ni) in the Patients with Parkinson's Disease.
abstract: Micronutrients and trace elements have been identified to play an important role in the development of Parkinson's disease (PD). In our previous study, we observed that prolidase activity is associated with oxidative stress and progression of PD. In present study, we aimed to study the association of prolidase-associated trace elements, such as Co, Mn, Ni, and Zn in the plasma of patients with PD by inductively coupled plasma spectrometry. Plasma levels of Co, Mn, and Ni were significantly increased, whereas plasma levels of Zn was significantly decreased (all P < 0.05) in the patients with PD than healthy controls. Plasma prolidase activity was not correlated to its associated trace elements in PD. A positive, linear, and significant correlation was observed between age and Co, and Mn, and Ni while negative and non-significant between age and status of Zn in the patients. Co, Mn, and Ni were continually elevated with increase in age as well as duration of disease in the patients with PD, whereas status of Zn was continually decreased. Thus, the study concluded that trace elements Co, Ni, and Mn status were increased and Zn status was decreased in the plasma of patients with PD. It is also concluded that elevated Co, Mn, and Ni has been associated with progression of Parkinson's disease.
authors.affiliation: Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Akhilesh Kumar
authors.initials: AK
authors.lastname: Verma
authors.affiliation: Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Anand Kumar
authors.initials: AK
authors.lastname: Keshari
authors.affiliation: Department of Neurosurgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Janak
authors.initials: J
authors.lastname: Raj
authors.affiliation: Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Renu
authors.initials: R
authors.lastname: Kumari
authors.affiliation: Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Kumar
authors.affiliation: Department of Neurosurgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Sharma
authors.affiliation: Division of Biostatistics, Department of Community Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
authors.forename: Tej Bali
authors.initials: TB
authors.lastname: Singh
authors.affiliation: Department of Oral Pathology, Jaipur Dental College, Jaipur, Rajasthan, 302020, India.
authors.forename: Shalabh
authors.initials: S
authors.lastname: Srivastava
authors.affiliation: Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India. ragsriv@gmail.com.
authors.forename: Ragini
authors.initials: R
authors.lastname: Srivastava
mesh_terms: D000328:Adult; D000368:Aged; D004150:Dipeptidases / Q000097:blood* / Q000378:metabolism; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000378:metabolism; D014131:Trace Elements / Q000097:blood*
chemical_list: D014131:Trace Elements; D004150:Dipeptidases; C022449:proline dipeptidase
keywords: Co; Mn; Ni; Parkinson’s disease; Prolidase activity; Trace elements; Zn