title: A mixed-crystal lanthanide zeolite-like metal-organic framework as a fluorescent indicator for lysophosphatidic acid, a cancer biomarker.
abstract: Two lanthanide zeolite-like metal-organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb(3+) and Eu(3+) ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4-43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.
authors.affiliation: Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin 300071, P. R. China.|Department of Chemical & Environmental Science and Materials and Surface Science Institute, University of Limerick , Limerick, Republic of Ireland.
authors.forename: Shi-Yuan
authors.initials: SY
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin 300071, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin 300071, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cheng
authors.affiliation: Department of Chemical & Environmental Science and Materials and Surface Science Institute, University of Limerick , Limerick, Republic of Ireland.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Zaworotko
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D005833:Genital Neoplasms, Female / Q000175:diagnosis*; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry; D008246:Lysophospholipids / Q000032:analysis*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D017641:Zeolites / Q000737:chemistry
chemical_list: D014408:Biomarkers, Tumor; D005456:Fluorescent Dyes; D028581:Lanthanoid Series Elements; D008246:Lysophospholipids; D009942:Organometallic Compounds; D017641:Zeolites; C032881:lysophosphatidic acid