title: Diamine Functionalized Cubic Mesoporous Silica for Ibuprofen Controlled Delivery.
abstract: A diamine functionalized cubic mesostructured KIT-6 (N-KIT-6) has been prepared by post-synthetic method using calcined mesoporous KIT-6 with a diamine source, i.e., N-'[3-(tri methoxysilyl)- propyl]'ethylenediamine. The KIT-6 mesoporous silica used for N-KIT-6 was synthesized under weak acidic hydrothermal method using bitemplates, viz., Pluronic P123 and 1-butanol. The synthesized mesoporous materials, KIT-6 and N-KIT-6, have been characterized by the relevant instrumental techniques such as SAXS, N2 sorption isotherm, FT-IR, SEM, TEM and TGA to prove the standard mesoporous materials with the identification of diamine groups. The characterized mesoporous materials, KIT-6 and N-KIT-6, have been extensively used in the potential application of controlled drug delivery, where ibuprofen (IBU) employed as a model drug. The rate of IBU adsorption and release was monitored by UV vis-spectrometer. On the basis of the experimental results of controlled drug delivery system, the results of IBU adsorption and releasing rate in N-KIT-6 are higher than those of KIT-6 because of the higher hydrophobic nature as well as rich basic sites on the surface of inner pore wall silica.
authors.forename: J
authors.initials: J
authors.lastname: Sivaguru
authors.forename: M
authors.initials: M
authors.lastname: Selvaraj
authors.forename: S
authors.initials: S
authors.lastname: Ravi
authors.forename: H
authors.initials: H
authors.lastname: Park
authors.forename: C W
authors.initials: CW
authors.lastname: Song
authors.forename: H H
authors.initials: HH
authors.lastname: Chun
authors.forename: C-S
authors.initials: CS
authors.lastname: Ha
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003959:Diamines / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D018712:Analgesics, Non-Narcotic; D003692:Delayed-Action Preparations; D003959:Diamines; D012822:Silicon Dioxide; D007052:Ibuprofen