title: Dosimetric comparison of carbon ion radiotherapy and stereotactic body radiotherapy with photon beams for the treatment of hepatocellular carcinoma.
abstract: BACKGROUND
  The purpose of this study was to compare carbon ion radiotherapy (C-ion RT) and stereotactic radiotherapy (SBRT) with photon beams for the treatment of hepatocellular carcinoma (HCC), specifically with regard to the dose volume parameters for target coverage and normal tissue sparing.
  
  
  METHODS
  Data of 10 patients who were treated using C-ion RT with a total dose of 60 Gy(RBE) in four fractions were used. The virtual plan of SBRT was simulated on the treatment planning computed tomography images of C-ion RT. Dose volume parameters such as minimum dose covering 90% of the planning target volume (PTV D90), homogeneity index (HI), conformity index (CI), mean liver dose (MLD), volume of the liver receiving 5 to 60 Gy (V5-60), and max point dose (Dmax) of gastrointestinal (GI) tract were calculated from both treatment plans.
  
  
  RESULTS
  The PTV D90 was 59.6 ± 0.2 Gy(RBE) in C-ion RT, as compared to 56.6 ± 0.3 Gy in SBRT (p < 0.05). HI and CI were 1.19 ± 0.03 and 0.79 ± 0.06, respectively in C-ion RT, as compared to 1.21 ± 0.01 and 0.37 ± 0.02, respectively in SBRT. Only CI showed a significant difference between two modalities. Mean liver dose was 8.1 ± 1.4 Gy(RBE) in C-ion RT, as compared to 16.1 ± 2.5 Gy in SBRT (p < 0.05). V5 to V50 of liver were higher in SBRT than C-ion RT and significant differences were observed for V5, V10 and V20. Dmax of the GI tract was higher in SBRT than C-ion RT, but did not show a significantly difference.
  
  
  CONCLUSIONS
  C-ion RT provides an advantage in both target conformity and normal liver sparing compared with SBRT.
authors.affiliation: Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. mrtaka100@yahoo.co.jp.
authors.forename: Takanori
authors.initials: T
authors.lastname: Abe
authors.affiliation: Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. junsaito@showa.gunma-u.ac.jp.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Saitoh
authors.affiliation: Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. m07201029@kdp.biglobe.ne.jp.
authors.forename: Daijiro
authors.initials: D
authors.lastname: Kobayashi
authors.affiliation: Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. k-shibu@med.gunma-u.ac.jp.
authors.forename: Kei
authors.initials: K
authors.lastname: Shibuya
authors.affiliation: Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. yoshin.koyama@gunma-u.ac.jp.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Koyama
authors.affiliation: Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. shimada@gunma-u.ac.jp.
authors.forename: Hirohumi
authors.initials: H
authors.lastname: Shimada
authors.affiliation: Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. kshirai@gunma-u.ac.jp.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Shirai
authors.affiliation: Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. tohno@gunma-u.ac.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ohno
authors.affiliation: Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. tnakano@gunma-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy*; D063193:Heavy Ion Radiotherapy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy*; D017785:Photons; D011874:Radiometry; D016634:Radiosurgery / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted; D012189:Retrospective Studies