title: Pathogenesis of venous ulcer.
abstract: The underlying pathophysiology of venous ulceration is venous hypertension, which initiates a complex cascade of cellular humeral events that are then magnified by genetic factors. Hemodynamic abnormalities are features of primary and secondary chronic venous diseases that lead to disease progression. Through a sequence of events, some patients develop venous leg ulcers, if the process is not interrupted. The exact science of the pathophysiology of the progression of chronic venous disease to venous leg ulcers is still in its infancy, but the framework for future study has been established.
authors.affiliation: Jobst Vascular Institute, 2109 Hughes Drive, Toledo, OH 43606. Electronic address: Anthony.ComerotaMD@ProMedica.org.
authors.forename: Anthony
authors.initials: A
authors.lastname: Comerota
authors.affiliation: Jobst Vascular Institute, 2109 Hughes Drive, Toledo, OH 43606.
authors.forename: Fedor
authors.initials: F
authors.lastname: Lurie
mesh_terms: D002908:Chronic Disease; D018450:Disease Progression; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D035002:Lower Extremity; D008297:Male; D010147:Pain Measurement; D010690:Phlebography / Q000379:methods; D011379:Prognosis; D018570:Risk Assessment; D016038:Skin Transplantation / Q000379:methods*; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000503:physiopathology* / Q000601:surgery; D014689:Venous Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*