title: Five-year prospective evaluation of thyroid function in girls with subclinical mild hypothyroidism of different etiology.
abstract: OBJECTIVE
  To follow-up for 5 years thyroid status evolution in 127 girls with mild (TSH 5-10 mU/l) subclinical hypothyroidism (SH) of different etiologies.
  
  
  METHODS
  The population was divided into two age-matched groups of 42 and 85 girls with either idiopathic (group A) or Hashimoto's thyroiditis (HT)-related SH (group B). Group B was in turn divided into three subgroups, according to whether SH was either isolated or associated with Turner syndrome (TS) or Down syndrome (DS).
  
  
  RESULTS
  At the end of follow-up the rate of girls who became euthyroid was higher in group A (61.9% vs 10.6%), whereas the rates of patients who remained SH (55.3% vs 26.2%), became overtly hypothyroid (30.6% vs 11.9%) or required levothyroxine (l-T4) therapy (63.5% vs 23.8%) were higher in group B. Among the girls of group B, the risk of remaining SH or developing overt hypothyroidism was higher in the subgroups with TS or DS than in those with isolated HT.
  
  
  CONCLUSIONS
  Long-term prognosis of mild and idiopathic SH is frequently benign, even though a l-T4 treatment may be needed throughout follow-up in almost a quarter of cases; long-term prognosis is different in the girls with either idiopathic or HT-related SH; and the association with either TS or DS impairs the outcome of HT-related SH.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wasniewska
authors.forename: Tommaso
authors.initials: T
authors.lastname: Aversa
authors.affiliation: Department of PediatricGynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyPediatric Endocrinology UnitDepartment of Translational Medical Sciences, University 'Federico II', Naples, ItalyDepartment of PediatricsUniversity of Turin, Turin, Italy.
authors.forename: Mariacarolina
authors.initials: M
authors.lastname: Salerno
authors.affiliation: Department of PediatricGynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyPediatric Endocrinology UnitDepartment of Translational Medical Sciences, University 'Federico II', Naples, ItalyDepartment of PediatricsUniversity of Turin, Turin, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Corrias
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Messina
authors.affiliation: Department of PediatricGynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyPediatric Endocrinology UnitDepartment of Translational Medical Sciences, University 'Federico II', Naples, ItalyDepartment of PediatricsUniversity of Turin, Turin, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mussa
authors.affiliation: Department of PediatricGynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyPediatric Endocrinology UnitDepartment of Translational Medical Sciences, University 'Federico II', Naples, ItalyDepartment of PediatricsUniversity of Turin, Turin, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Capalbo
authors.forename: Filippo
authors.initials: F
authors.lastname: De Luca
authors.forename: Mariella
authors.initials: M
authors.lastname: Valenzise
mesh_terms: D000293:Adolescent; D058070:Asymptomatic Diseases; D001323:Autoantibodies / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D050031:Hashimoto Disease / Q000150:complications* / Q000276:immunology; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D007453:Iodide Peroxidase / Q000276:immunology; D008137:Longitudinal Studies; D011446:Prospective Studies; D012075:Remission, Spontaneous; D012720:Severity of Illness Index; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism*; D014424:Turner Syndrome / Q000150:complications*
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D013972:Thyrotropin; D007453:Iodide Peroxidase; D013974:Thyroxine