title: Glycosylation of solute carriers: mechanisms and functional consequences.
abstract: Solute carriers (SLCs) are one of the largest groups of multi-spanning membrane proteins in mammals and include ubiquitously expressed proteins as well as proteins with highly restricted tissue expression. A vast number of studies have addressed the function and organization of SLCs as well as their posttranslational regulation, but only relatively little is known about the role of SLC glycosylation. Glycosylation is one of the most abundant posttranslational modifications of animal proteins and through recent advances in our understanding of protein-glycan interactions, the functional roles of SLC glycosylation are slowly emerging. The purpose of this review is to provide a concise overview of the aspects of glycobiology most relevant to SLCs, to discuss the roles of glycosylation in the regulation and function of SLCs, and to outline the major open questions in this field, which can now be addressed given major technical advances in this and related fields of study in recent years.
authors.affiliation: Section of Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen O, Denmark. nis.pedersen@bio.ku.dk.
authors.forename: Nis Borbye
authors.identifier: http://orcid.org/0000-0003-3725-4533
authors.initials: NB
authors.lastname: Pedersen
authors.affiliation: Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Carlsson
authors.affiliation: Section of Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen O, Denmark.
authors.forename: Stine Falsig
authors.initials: SF
authors.lastname: Pedersen
mesh_terms: D000818:Animals; D006031:Glycosylation; D006801:Humans; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D026901:Membrane Transport Proteins; D011134:Polysaccharides
keywords: Epithelial transport; Glycobiology; Glycosylation; Posttranslational modification; Solute carriers