title: Prognostic Value of Dual-Time-Point 18F-FDG PET for Idiopathic Pulmonary Fibrosis.
abstract: The aim of this prospective study was to clarify whether dual-time-point (18)F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients.
  
  
  METHODS
  Fifty IPF patients underwent (18)F-FDG PET examinations at 2 time points: 60 min (early imaging) and 180 min (delayed imaging) after (18)F-FDG injection. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated, and then the results were compared with overall and progression-free survival.
  
  
  RESULTS
  A multivariate Cox proportional hazards model showed higher RI-SUV and higher extent of fibrosis score as independent predictors of shorter progression-free survival. The median progression-free survival for patients with negative RI-SUV was better than that for those with positive RI-SUV (27.9 vs. 13.3 mo, P = 0.0002). On the other hand, multivariate Cox analysis showed higher RI-SUV and lower forced vital capacity to be independent predictors of shorter overall survival. The 5-y survival rate for patients with negative RI-SUV was better than that for those with positive RI-SUV (76.8% vs. 14.3%, P = 0.00001). In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality (hazard ratio, 7.31; 95% confidence interval, 2.64-20.3; P = 0.0001).
  
  
  CONCLUSIONS
  Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF.
authors.affiliation: Third Department of Internal Medicine, University of Fukui, Yoshida-gun, Fukui, Japan umeda@u-fukui.ac.jp.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Umeda
authors.affiliation: Department of Respiratory Medicine, Fukui Red Cross Hospital, Fukui-shi, Fukui, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Demura
authors.affiliation: Third Department of Internal Medicine, University of Fukui, Yoshida-gun, Fukui, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Morikawa
authors.affiliation: Third Department of Internal Medicine, University of Fukui, Yoshida-gun, Fukui, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Anzai
authors.affiliation: Third Department of Internal Medicine, University of Fukui, Yoshida-gun, Fukui, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Kadowaki
authors.affiliation: Third Department of Internal Medicine, University of Fukui, Yoshida-gun, Fukui, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Ameshima
authors.affiliation: Department of Radiology, University of Fukui, Yoshida-gun, Fukui, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Tsuchida
authors.affiliation: Biomedical Imaging Research Center, University of Fukui, Yoshida-gun, Fukui, Japan; and.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsujikawa
authors.affiliation: Biomedical Imaging Research Center, University of Fukui, Yoshida-gun, Fukui, Japan; and.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kiyono
authors.affiliation: Biomedical Imaging Research Center, University of Fukui, Yoshida-gun, Fukui, Japan; and.
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Okazawa
authors.affiliation: Respiratory Diseases Center of Northern Noto Area, Ishikawa Prefecture, Anamizu-cho, Ishikawa, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishizaki
authors.affiliation: Third Department of Internal Medicine, University of Fukui, Yoshida-gun, Fukui, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Ishizuka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012307:Risk Factors; D013909:Thorax / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: fluorodeoxyglucose 18F; idiopathic pulmonary fibrosis; positron emission tomography; survival analysis