title: The value of histopathological examination of salivary gland biopsies in diagnosis, prognosis and treatment of Sjögren's Syndrome.
abstract: Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterised by local exocrine glandular involvement and systemic multiorgan manifestations. In this review we will discuss the value of the histological examination of the salivary glands in the classification criteria, and more recently as prognostic tool for patient stratification and monitoring. The limitations of the current tools used to assess salivary gland pathology in pSS will also be reviewed in relation to using salivary gland biopsy analysis as an outcome measure in clinical trials.
authors.affiliation: Rheumatology Research Group, School of Immunity and Infection, University of Birmingham, United Kingdom.
authors.forename: Francesca
authors.initials: F
authors.lastname: Barone
authors.affiliation: Rheumatology Research Group, School of Immunity and Infection, University of Birmingham, United Kingdom.
authors.forename: Joana
authors.initials: J
authors.lastname: Campos
authors.affiliation: Rheumatology Research Group, School of Immunity and Infection, University of Birmingham, United Kingdom.
authors.forename: Simon
authors.initials: S
authors.lastname: Bowman
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Fisher
mesh_terms: D001706:Biopsy; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D012469:Salivary Glands / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy