title: Potential influence of Type A personality on plasma C-reactive protein levels in people with diabetes.
abstract: OBJECTIVE
  Type A personality, although classically known as a factor linked to increased vascular risk, has recently been associated with increased survival in patients with diabetes. As low-grade inflammation predicts a poor outcome, the present study explored the potential associations between Type A and plasma levels of C-reactive protein (CRP) in diabetes.
  
  
  METHODS
  Type A personality was assessed by the Bortner questionnaire in people with diabetes. The association between Type A and plasma CRP levels was examined by multivariable linear regression, and structural equation modelling (SEM) was performed to determine the impact of the major clinical, biological and psychological confounders.
  
  
  RESULTS
  The study included 626 participants with type 1 and type 2 diabetes from the Diabetes and Psychological Profile study. Multivariable analyses showed an independent inverse association between Type A score and CRP levels. The structural model adjusted for age, gender, diabetes type and duration, body mass index (BMI), smoking status, alcohol abuse, oral antidiabetic and statin treatments, HbA1c levels, lipids, perceived stress, anxiety and depression revealed significant associations between CRP and Type A (β=-0.135, 95% CI: -0.242, -0.028; P=0.014), BMI (β=0.194, 95% CI: 0.038, 0.350; P=0.015) and HDL cholesterol (β=-0.132, 95% CI: -0.245, -0.020; P=0.014).
  
  
  CONCLUSIONS
  Our present study data indicate that Type A personality is independently associated with lower CRP levels. This lower level of inflammation might explain the better clinical outcomes associated with Type A personality in patients with diabetes.
authors.affiliation: Psychiatry unit, department of neurosciences, Marion building, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Laboratory of psychopathology and medical psychology (IFR 100), university of Burgundy, 21000 Dijon, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Chauvet-Gélinier
authors.affiliation: Psychiatry unit, department of neurosciences, Marion building, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Laboratory of psychopathology and medical psychology (IFR 100), university of Burgundy, 21000 Dijon, France.
authors.forename: B
authors.initials: B
authors.lastname: Trojak
authors.affiliation: Faculté de médecine, université Paris-Descartes, Sorbonne Paris-Cité, 75015 Paris, France; Service de psychiatrie de l'adulte et du sujet âgé, hôpitaux universitaires Paris-Ouest, AP-HP, 20, rue Leblanc, 75015 Paris, France; Inserm, U894 centre for psychiatry and neuroscience, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Lemogne
authors.affiliation: Department of hospital hygiene and epidemiology, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France.
authors.forename: L-S
authors.initials: LS
authors.lastname: Aho-Glélé
authors.affiliation: Department of endocrinology and metabolic diseases, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Department of endocrinology and metabolic diseases, Inserm Research Center 866, CHU Le Bocage, 2, boulevard Maréchal-de-Lattre-de-Tassigny, 21000 Dijon, France.
authors.forename: M-C
authors.initials: MC
authors.lastname: Brindisi
authors.affiliation: Department of endocrinology and metabolic diseases, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Department of endocrinology and metabolic diseases, Inserm Research Center 866, CHU Le Bocage, 2, boulevard Maréchal-de-Lattre-de-Tassigny, 21000 Dijon, France.
authors.forename: B
authors.initials: B
authors.lastname: Bouillet
authors.affiliation: Psychiatry unit, department of neurosciences, Marion building, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Laboratory of psychopathology and medical psychology (IFR 100), university of Burgundy, 21000 Dijon, France.
authors.forename: E
authors.initials: E
authors.lastname: Ponavoy
authors.affiliation: Psychiatry unit, department of neurosciences, Marion building, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Laboratory of psychopathology and medical psychology (IFR 100), university of Burgundy, 21000 Dijon, France.
authors.forename: V
authors.initials: V
authors.lastname: Meille
authors.affiliation: Department of endocrinology and metabolic diseases, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Department of endocrinology and metabolic diseases, Inserm Research Center 866, CHU Le Bocage, 2, boulevard Maréchal-de-Lattre-de-Tassigny, 21000 Dijon, France.
authors.forename: I
authors.initials: I
authors.lastname: Simoneau
authors.affiliation: Laboratory of psychopathology and medical psychology (IFR 100), university of Burgundy, 21000 Dijon, France.
authors.forename: K
authors.initials: K
authors.lastname: Chahraoui
authors.affiliation: Department of endocrinology and metabolic diseases, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Department of endocrinology and metabolic diseases, Inserm Research Center 866, CHU Le Bocage, 2, boulevard Maréchal-de-Lattre-de-Tassigny, 21000 Dijon, France.
authors.forename: G
authors.initials: G
authors.lastname: Vaillant
authors.affiliation: Department of endocrinology and metabolic diseases, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Department of endocrinology and metabolic diseases, Inserm Research Center 866, CHU Le Bocage, 2, boulevard Maréchal-de-Lattre-de-Tassigny, 21000 Dijon, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Petit
authors.affiliation: Faculté de médecine, université Paris-Descartes, Sorbonne Paris-Cité, 75015 Paris, France; Service de psychiatrie de l'adulte et du sujet âgé, hôpitaux universitaires Paris-Ouest, AP-HP, 20, rue Leblanc, 75015 Paris, France.
authors.forename: S M
authors.initials: SM
authors.lastname: Consoli
authors.affiliation: Psychiatry unit, department of neurosciences, Marion building, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Laboratory of psychopathology and medical psychology (IFR 100), university of Burgundy, 21000 Dijon, France.
authors.forename: B
authors.initials: B
authors.lastname: Bonin
authors.affiliation: Department of endocrinology and metabolic diseases, university hospital CHU Le Bocage, 14, rue Gaffarel, 21000 Dijon, France; Department of endocrinology and metabolic diseases, Inserm Research Center 866, CHU Le Bocage, 2, boulevard Maréchal-de-Lattre-de-Tassigny, 21000 Dijon, France. Electronic address: bruno.verges@chu-dijon.fr.
authors.forename: B
authors.initials: B
authors.lastname: Vergès
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D014434:Type A Personality
chemical_list: D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: C-reactive protein; Diabetes; Inflammation; Personality; Type A