title: The evidence for low-dose CT screening of lung cancer.
abstract: Lung cancer remains the leading cause of cancer-related death in the United States. An effective screening tool for early lung cancer detection has long been sought. Early chest radiograph and low-dose computed tomography (LDCT) screening trials were promising and demonstrated increased cancer detection. However, these studies were not able to improve lung cancer mortality. The National Lung Screening Trial resulted in decreased lung cancer mortality with LDCT screening in a high-risk population. Similar trials are currently underway in Europe. With LDCT now being widely implemented, it is paramount for radiologists to understand the evidence for lung cancer screening.
authors.affiliation: David Geffen School of Medicine at UCLA, Department of Radiology, 757 Westwood Plaza, Ste 1621, Los Angeles, CA, 90095-1721. Electronic address: kruchalski@mednet.ucla.edu.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Ruchalski
authors.affiliation: David Geffen School of Medicine at UCLA, Department of Radiology, 757 Westwood Plaza, Ste 1621, Los Angeles, CA, 90095-1721.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gutierrez
authors.affiliation: David Geffen School of Medicine at UCLA, Department of Radiology, 757 Westwood Plaza, Ste 1621, Los Angeles, CA, 90095-1721.
authors.forename: Scott
authors.initials: S
authors.lastname: Genshaft
authors.affiliation: David Geffen School of Medicine at UCLA, Department of Radiology, 757 Westwood Plaza, Ste 1621, Los Angeles, CA, 90095-1721.
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Abtin
authors.affiliation: David Geffen School of Medicine at UCLA, Department of Radiology, 757 Westwood Plaza, Ste 1621, Los Angeles, CA, 90095-1721.
authors.forename: Robert
authors.initials: R
authors.lastname: Suh
mesh_terms: D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D011829:Radiation Dosage; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Lung cancer screening; Lung-RADS; NLST; Nelson