title: Bispidine as a Privileged Scaffold.
abstract: Thediazabicyclic molecule bispidine named by the chemist Carl Mannich in 1930, is a naturally occurring scaffold with interesting features. Bispidine can form different conformers, has high basicity, can attack dichloromethane, has metal ion coordination properties and interacts with nicotinic acetylcholine receptors. In this review we will discuss important properties, synthetic pathways and biological activities of bispidine and some derivatives. Bispidine can function as a scaffold for compounds with very diverse biological activities, e.g. interacting with ion channels, G-protein coupled receptors, and enzymes, and is even used for the development of new in vivo radiotracers.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Tomassoli
authors.affiliation: Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, U.S.A. danielag@hawaii.edu.
authors.forename: Daniela
authors.initials: D
authors.lastname: Gündisch
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000931:Antidotes / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011869:Radioligand Assay; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D000931:Antidotes; D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007473:Ion Channels; D010975:Platelet Aggregation Inhibitors; D011956:Receptors, Cell Surface; C495809:bispidine