title: Impulse oscillometry in acute and stable asthmatic children: a comparison with spirometry.
abstract: OBJECTIVE
  Lung function tests have attracted interest for the diagnosis and follow-up of childhood asthma in recent years. For patients who cannot perform forced expiratory maneuvers, impulse oscillometry (IOS), performed during spontaneous breathing, may be an alternative tool.
  
  
  METHODS
  Thirty-five acute, 107 stable asthmatic and 103 healthy children who presented to our clinic performed IOS followed by spirometry before and after salbutamol inhalation. The mean baseline and reversibility of IOS and spirometry parameters were compared between the groups. Correlation analyses were undertaken within the asthmatics, and the healthy controls separately. To distinguish the three groups, the sensitivity and specificity of baseline and reversibility values of IOS and spirometry were computed. When spirometry was taken as the gold standard, the discriminating performance of IOS to detect the airway obstruction and reversibility was investigated.
  
  
  RESULTS
  The mean absolute values of Zrs, R5, R5-R20, X5, X10, X15, Fres, AX, and all spirometric parameters, and the mean reversibility values of R5, R10, Fres, AX and forced expiratory volume in one second were different between the groups and the highest area under curve values to discriminate the groups was obtained from area of reactance (AX) and ΔAX. Zrs, all resistance (including R5-R20) and reactance parameters, Fres and AX were correlated with at least one spirometric parameter. Spirometric reversibility was detected by ≤-22.34 and ≤-39.05 cut-off values of ΔR5 and ΔAX, respectively.
  
  
  CONCLUSIONS
  IOS has shown a highly significant association with spirometric indices and reversibility testing. It may be a substitute for spirometry in children who fail to perform forced expiratory maneuvers.
authors.affiliation: a Division of Allergy and Immunology, Department of Pediatrics , Medical School, Mersin University , Mersin , Turkey and.
authors.forename: Sehra Birgul
authors.initials: SB
authors.lastname: Batmaz
authors.affiliation: a Division of Allergy and Immunology, Department of Pediatrics , Medical School, Mersin University , Mersin , Turkey and.
authors.forename: Semanur
authors.initials: S
authors.lastname: Kuyucu
authors.affiliation: a Division of Allergy and Immunology, Department of Pediatrics , Medical School, Mersin University , Mersin , Turkey and.
authors.forename: Tugba
authors.initials: T
authors.lastname: Arıkoglu
authors.affiliation: b Pediatrics Clinic, Kars State Hospital , Kars , Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Tezol
authors.affiliation: a Division of Allergy and Immunology, Department of Pediatrics , Medical School, Mersin University , Mersin , Turkey and.
authors.forename: Ayse
authors.initials: A
authors.lastname: Aydogdu
mesh_terms: D000293:Adolescent; D000420:Albuterol / Q000008:administration & dosage; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology*; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009991:Oscillometry; D012680:Sensitivity and Specificity; D013147:Spirometry
chemical_list: D000420:Albuterol
keywords: Childhood; impulse oscillometry; reversibility; spirometry