title: Resolving the Origin of Rabbit Hemorrhagic Disease Virus: Insights from an Investigation of the Viral Stocks Released in Australia.
abstract: To resolve the evolutionary history of rabbit hemorrhagic disease virus (RHDV), we performed a genomic analysis of the viral stocks imported and released as a biocontrol measure in Australia, as well as a global phylogenetic analysis. Importantly, conflicts were identified between the sequences determined here and those previously published that may have affected evolutionary rate estimates. By removing likely erroneous sequences, we show that RHDV emerged only shortly before its initial description in China.
authors.affiliation: Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW, Australia Centre for Virus Research, Westmead Millennium Institute, Westmead, NSW, Australia.
authors.forename: John-Sebastian
authors.initials: JS
authors.lastname: Eden
authors.affiliation: Invasive Animals Cooperative Research Centre, University of Canberra, Bruce, ACT, Australia Elizabeth Macarthur Agricultural Institute, Menangle, NSW, Australia.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Read
authors.affiliation: Invasive Animals Cooperative Research Centre, University of Canberra, Bruce, ACT, Australia Landcare Research, Wildlife Ecology & Management, Lincoln, New Zealand.
authors.forename: Janine A
authors.initials: JA
authors.lastname: Duckworth
authors.affiliation: Invasive Animals Cooperative Research Centre, University of Canberra, Bruce, ACT, Australia Commonwealth Scientific and Industrial Research Organisation-Health & Biosecurity, Black Mountain, ACT, Australia.
authors.forename: Tanja
authors.initials: T
authors.lastname: Strive
authors.affiliation: Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW, Australia edward.holmes@sydney.edu.au.
authors.forename: Edward C
authors.initials: EC
authors.lastname: Holmes
mesh_terms: D001315:Australia; D001483:Base Sequence; D019295:Computational Biology; D019143:Evolution, Molecular; D017929:Hemorrhagic Disease Virus, Rabbit / Q000737:chemistry / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017422:Sequence Analysis, DNA