title: Congenital and acquired bleeding disorders in infancy.
abstract: The diagnosis of congenital and acquired bleeding disorders in infants requires an understanding of developmental haemostasis and the effect on laboratory testing. A systematic approach to bleeding in neonates will aid clinicians in the diagnosis and treatment, which may be caused by a wide variety of diseases. The clinical setting will help to direct the diagnostic pathway. This review will focus on the presentation and diagnosis of congenital and acquired bleeding disorders, including platelet disorders. Current research in this field is ongoing, including investigation into neonatal platelets and their different functionalities, platelet transfusion thresholds and how changes in coagulation factors may be linked to other homeostatic mechanisms.
authors.affiliation: Royal Children's Hospital, 50 Flemington Road, Parkville, Melbourne 3052 Australia; Clinical Haematology - Royal Children's Hospital, University of Melbourne, Melbourne Australia. Electronic address: sally.campbell@rch.org.au.
authors.forename: Sally Elizabeth
authors.initials: SE
authors.lastname: Campbell
authors.affiliation: Serious Hazards of Transfusion UK Haemovigilance Scheme, Manchester Blood Centre, Plymouth Grove, Manchester M13 9LL, UK. Electronic address: paula.bolton-maggs@manchester.ac.uk.
authors.forename: Paula H B
authors.initials: PH
authors.lastname: Bolton-Maggs
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood / Q000151:congenital* / Q000628:therapy; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D001791:Blood Platelet Disorders / Q000097:blood / Q000151:congenital / Q000628:therapy; D001792:Blood Platelets / Q000473:pathology / Q000502:physiology; D006470:Hemorrhage / Q000097:blood / Q000151:congenital* / Q000628:therapy; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000209:etiology / Q000628:therapy; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications / Q000151:congenital / Q000628:therapy
chemical_list: D001779:Blood Coagulation Factors
keywords: Acquired bleeding disorders; Congenital bleeding disorders; Developmental haemostasis; Infant; Platelet disorders