title: Transcriptional Activation of the Zygotic Genome in Drosophila.
abstract: During the first stages of metazoan development, the genomes of the highly specified sperm and egg must unite and be reprogrammed to allow for the generation of a new organism. This process is controlled by maternally deposited products. Initially, the zygotic genome is largely transcriptionally quiescent, and it is not until hours later that the zygotic genome takes control of development. The transcriptional activation of the zygotic genome is tightly coordinated with the degradation of the maternal products. Here, we review the current understanding of the processes that mediate the reprogramming of the early embryonic genome and facilitate transcriptional activation during the early stages of Drosophila development.
authors.affiliation: Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: mharrison3@wisc.edu.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Harrison
authors.affiliation: Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA; Department of Integrative Biology, University of California, Berkeley, Berkeley, California, USA; QB3 Institute, University of California, Berkeley, Berkeley, California, USA. Electronic address: mbeisen@lbl.gov.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Eisen
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D049750:Genome, Insect; D008954:Models, Biological; D015533:Transcriptional Activation / Q000235:genetics*; D015053:Zygote / Q000378:metabolism*
chemical_list: D002843:Chromatin
keywords: Chromatin; Differentiation; Drosophila; Gene expression; Zygotic genome activation