title: Phosphoinositides in Ca(2+) signaling and excitation-contraction coupling in skeletal muscle: an old player and newcomers.
abstract: Since the postulate, 30 years ago, that phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P 2) as the precursor of inositol 1,4,5-trisphosphate (Ins(1,4,5)P 3) would be critical for skeletal muscle excitation-contraction (EC) coupling, the issue of whether phosphoinositides (PtdInsPs) may have something to do with Ca(2+) signaling in muscle raised limited interest, if any. In recent years however, the PtdInsP world has expanded considerably with new functions for PtdIns(4,5)P 2 but also with functions for the other members of the PtdInsP family. In this context, the discovery that genetic deficiency in a PtdInsP phosphatase has dramatic consequences on Ca(2+) homeostasis in skeletal muscle came unanticipated and opened up new perspectives in regards to how PtdInsPs modulate muscle Ca(2+) signaling under normal and disease conditions. This review intends to make an update of the established, the questioned, and the unknown regarding the role of PtdInsPs in skeletal muscle Ca(2+) homeostasis and EC coupling, with very specific emphasis given to Ca(2+) signals in differentiated skeletal muscle fibers.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Csernoch
authors.affiliation: UMR CNRS 5534, Centre de Génétique et de Physiologie Moléculaire et Cellulaire, Université Lyon 1, Bât. Raphaël Dubois, 43 boulevard du 11 novembre 1918, 69622, Villeurbanne, France. vincent.jacquemond@univ-lyon1.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Jacquemond
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology*; D018485:Muscle Fibers, Skeletal / Q000378:metabolism* / Q000502:physiology*; D010716:Phosphatidylinositols / Q000378:metabolism*
chemical_list: D010716:Phosphatidylinositols; D002118:Calcium
keywords: Calcium homeostasis; Excitation–contraction coupling; Phosphoinositide; Ryanodine receptor; Sarcoplasmic reticulum Ca2+ release; Skeletal muscle fibers