title: IL-31 and IL-33 circulating levels in allergic contact dermatitis.
abstract: Enhanced IL-31 expression in skin biopsies is present in allergic contact dermatitis (ACD). IL-33 expression is induced in keratinocytes and in skin of ACD patients. This overexpression is present in both allergic and irritant conditions. The aim of this work was to test the systemic involvement of IL-31 and IL-33 in ACD. IL-31 levels were significantly higher in patients than in controls. IL-33 serum levels, on the contrary, were similar in patients and controls. This work shows a possible systemic involvement of IL-31 and the absence of a systemic involvement of IL-33 in ACD. IL-31 levels do not seem related to the allergen involved, and did not change on the strength of the allergen involved. More likely, IL-31 levels are related to the itch. IL-33, instead, is secreted from damaged or inflamed tissue and might function as an early warning system at the site of skin damage. In the future, IL-31 could be a possible therapeutic target of all pruritic skin diseases resistant to conventional therapies.
authors.affiliation: Department of Clinical and Experimental Medicine-Dermatology, University of Messina, Messina, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Guarneri
authors.affiliation: Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. UOC Allergologia e Immunologia Clinica Policlinico Universitario Via Consolare Valeria 98125 Messina, Italy. Phone: +39 090 221 20 49 Fax: +39 090 694 773 E-mail: pminciullo@unime.it.
authors.forename: P L
authors.initials: PL
authors.lastname: Minciullo
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Mannucci
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Calapai
authors.affiliation: Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Saitta
authors.affiliation: Department of Clinical and Experimental Medicine-Dermatology, University of Messina, Messina, Italy.
authors.forename: S P
authors.initials: SP
authors.lastname: Cannavò
authors.affiliation: Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. Institute of Clinical Physiology, IFC CNR, Messina Unit, Messina, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Gangemi
mesh_terms: D000293:Adolescent; D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D000067596:Interleukin-33 / Q000097:blood / Q000502:physiology*; D007378:Interleukins / Q000097:blood / Q000502:physiology*; D008297:Male; D008875:Middle Aged
chemical_list: C502187:IL31 protein, human; C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins
keywords: Allergic contact dermatitis; cytokines; interleukin-31; interleukin-33; pruritic skin disease; pruritus