title: Inverse correlation between fibrinogen and bone mineral density in women: Preliminary findings.
abstract: Hemostatic factors may be involved in bone health. The present preliminary study investigated the association between plasma fibrinogen and bone mineral density (BMD) in perimenopausal women. A significant inverse correlation between fibrinogen and BMD was observed (correlation coefficient = -0.42, p < 0.01). This correlation appeared to be more clearly observed in the subgroup with a high level of high-sensitivity C-reactive protein than in that with a low level of high-sensitivity C-reactive protein, and in the subgroup with a high level of diacron reactive oxygen metabolites (an oxidative stress marker) than in that with a low level of diacron reactive oxygen metabolites. Thus, fibrinogen may be a possible marker of BMD in this population. More studies on the associations among hemostasis, inflammation, oxidative stress, and bone metabolism are warranted in the clinical setting.
authors.affiliation: Jui-Tung Chen Clinic, Tokyo, Japan. Electronic address: chin-cl@m.jcnnet.jp.
authors.forename: Jui-Tung
authors.initials: JT
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
mesh_terms: D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood*; D018384:Oxidative Stress; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D005340:Fibrinogen; D002097:C-Reactive Protein
keywords: C-reactive protein (CRP); diacron reactive oxygen metabolites (d-ROMs); fibrinogen; osteoporosis; oxidative stress