title: Targeting the glucocorticoid receptor in breast and prostate cancers.
abstract: Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.
authors.affiliation: Department of Medicine, Section of Hematology/Oncology, The University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL 60637, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Kach
authors.affiliation: Department of Medicine, Section of Hematology/Oncology, The University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL 60637, USA. Ben May Department of Cancer Biology, The University of Chicago, 5841 S. Maryland Ave. MC 2115, Chicago, IL 60637, USA.
authors.forename: Suzanne D
authors.initials: SD
authors.lastname: Conzen
authors.affiliation: Department of Medicine, Section of Hematology/Oncology, The University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL 60637, USA. rszmulew@medicine.bsd.uchicago.edu.
authors.forename: Russell Z
authors.initials: RZ
authors.lastname: Szmulewitz
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D002470:Cell Survival; D047628:Estrogen Receptor alpha / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D011944:Receptors, Androgen / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D015398:Signal Transduction; D057170:Translational Research, Biomedical
chemical_list: C410798:AR protein, human; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D011944:Receptors, Androgen; D011965:Receptors, Glucocorticoid