title: Performance of 11C-Pittsburgh Compound B PET Binding Potential Images in the Detection of Amyloid Deposits on Equivocal Static Images.
abstract: The goal of this study was to clarify whether binding potential (BP) images using (11)C-Pittsburgh compound B ((11)C-PiB) and dynamic PET can reliably detect cortical amyloid deposits for patients whose (11)C-PiB PET static images are ambiguous and whether visual ratings are affected by white matter retention.
  
  
  METHODS
  Static and BP images were constructed for 85 consecutive patients with cognitive impairment after (11)C-PiB dynamic PET. Cortical uptake was visually assessed as positive, negative, or equivocal for both types of images. Quantitatively, the standardized uptake value ratio (SUVR) from the static image, the nondisplaceable BP from the dynamic image for mean gray matter uptake, and the ratio of gray matter uptake to white matter retention were compared among (11)C-PiB-positive, (11)C-PiB-equivocal, and (11)C-PiB-negative groups.
  
  
  RESULTS
  Forty-three scans were visually assessed as (11)C-PiB-positive in both the static and the BP images. Ten scans were (11)C-PiB-equivocal in the static images. In 8 of them, the BP images were (11)C-PiB-positive, whereas the other 2 were (11)C-PiB-equivocal. Thirty-two scans were assessed as (11)C-PiB-negative in the static images. In the BP images, 4 were (11)C-PiB-positive and 2 were (11)C-PiB-equivocal. The mean gray matter uptake of (11)C-PiB in SUVR and nondisplaceable BP, respectively, showed statistically significant differences among the (11)C-PiB-positive, (11)C-PiB-equivocal, and (11)C-PiB-negative groups. The ratio of gray matter uptake to white matter retention was lower in the BP images than static images from the (11)C-PiB-negative and (11)C-PiB-equivocal groups, whereas it was higher in the (11)C-PiB-positive group.
  
  
  CONCLUSIONS
  (11)C-PiB PET BP images can clarify visual interpretation of clinical static (11)C-PiB-equivocal images by reducing the interference of nonspecific white matter retention. We conclude that (11)C-PiB-equivocal PET findings on static images reflect cortical amyloid deposits, which can be verified using BP images. Furthermore, quantitative assessments, such as SUVR and nondisplaceable BP, are of no use for correctly rating equivocal visual findings.
authors.affiliation: Department of Radiology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan Institute of Advanced Clinical Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan ch4111@gmail.com.
authors.forename: Chisa
authors.initials: C
authors.lastname: Hosokawa
authors.affiliation: Department of Radiology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan Neurocognitive Disorders Center, Kinki University Hospital, Osakasayama, Osaka, Japan; and.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ishii
authors.affiliation: Kinki University Faculty of Biology-Oriented Science and Technology, Kinokawa, Wakayama, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Department of Radiology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hyodo
authors.affiliation: Department of Radiology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan Institute of Advanced Clinical Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hosono
authors.affiliation: Institute of Advanced Clinical Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Sakaguchi
authors.affiliation: Institute of Advanced Clinical Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Kimio
authors.initials: K
authors.lastname: Usami
authors.affiliation: Institute of Advanced Clinical Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Shimamoto
authors.affiliation: Institute of Advanced Clinical Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Yamazoe
authors.affiliation: Department of Radiology, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan Institute of Advanced Clinical Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan.
authors.forename: Takamichi
authors.initials: T
authors.lastname: Murakami
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000814:Aniline Compounds / Q000493:pharmacokinetics*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D013844:Thiazoles / Q000493:pharmacokinetics*; D066127:White Matter / Q000000981:diagnostic imaging / Q000378:metabolism
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D013844:Thiazoles
keywords: 11C-PiB; binding potential; equivocal; positron emission tomography; white matter retention