title: A Patient-Specific Foot Model for the Estimate of Ankle Joint Forces in Patients with Juvenile Idiopathic Arthritis.
abstract: Juvenile idiopathic arthritis (JIA) is the leading cause of childhood disability from a musculoskeletal disorder. It generally affects large joints such as the knee and the ankle, often causing structural damage. Different factors contribute to the damage onset, including altered joint loading and other mechanical factors, associated with pain and inflammation. The prediction of patients' joint loading can hence be a valuable tool in understanding the disease mechanisms involved in structural damage progression. A number of lower-limb musculoskeletal models have been proposed to analyse the hip and knee joints, but juvenile models of the foot are still lacking. This paper presents a modelling pipeline that allows the creation of juvenile patient-specific models starting from lower limb kinematics and foot and ankle MRI data. This pipeline has been applied to data from three children with JIA and the importance of patient-specific parameters and modelling assumptions has been tested in a sensitivity analysis focused on the variation of the joint reaction forces. This analysis highlighted the criticality of patient-specific definition of the ankle joint axes and location of the Achilles tendon insertions. Patient-specific detection of the Tibialis Anterior, Tibialis Posterior, and Peroneus Longus origins and insertions were also shown to be important.
authors.affiliation: Department of Mechanical Engineering, University of Sheffield, Pam Liversidge Building, Sheffield, S13JD, UK.|INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield, UK.
authors.forename: Joe A I
authors.initials: JA
authors.lastname: Prinold
authors.affiliation: Department of Mechanical Engineering, University of Sheffield, Pam Liversidge Building, Sheffield, S13JD, UK. c.mazza@sheffield.ac.uk.|INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield, UK. c.mazza@sheffield.ac.uk.
authors.forename: Claudia
authors.initials: C
authors.lastname: Mazzà
authors.affiliation: Department of Mechanical Engineering, University of Sheffield, Pam Liversidge Building, Sheffield, S13JD, UK.|Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Marco
authors.affiliation: Department of Mechanical Engineering, University of Sheffield, Pam Liversidge Building, Sheffield, S13JD, UK.|INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield, UK.
authors.forename: Iain
authors.initials: I
authors.lastname: Hannah
authors.affiliation: Pediatria II - Reumatologia, Istituto Giannina Gaslini, Genoa, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Malattia
authors.affiliation: Pediatric Rheumatology Unit, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Magni-Manzoni
authors.affiliation: Movement Analysis and Robotics Laboratory (MARLab), Neurorehabilitation Units, IRCCS Ospedale Pediatrico Bambino Gesù, Passoscuro, Rome, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Petrarca
authors.affiliation: UOC Medicina Fisica e Riabilitazione, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
authors.forename: Anna B
authors.initials: AB
authors.lastname: Ronchetti
authors.affiliation: Department of Imaging, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Tanturri de Horatio
authors.affiliation: Pediatria II - Reumatologia, Istituto Giannina Gaslini, Genoa, Italy.|Paediatric immunology, University Medical Centre Utrecht Wilhelmina Children's Hospital, Utrecht, The Netherlands.
authors.forename: E H Pieter
authors.initials: EH
authors.lastname: van Dijkhuizen
authors.affiliation: Visual Healthcare Technologies, Fraunhofer IGD, Darmstadt, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Wesarg
authors.affiliation: Department of Mechanical Engineering, University of Sheffield, Pam Liversidge Building, Sheffield, S13JD, UK.|INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield, UK.
authors.forename: Marco
authors.initials: M
authors.lastname: Viceconti
mesh_terms: D000293:Adolescent; D000843:Ankle Joint / Q000473:pathology / Q000503:physiopathology; D001171:Arthritis, Juvenile / Q000473:pathology / Q000503:physiopathology; D001696:Biomechanical Phenomena; D002648:Child; D005260:Female; D005528:Foot / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008954:Models, Biological; D057285:Precision Medicine / Q000379:methods; D016474:Weight-Bearing
keywords: Foot; Lower-limb; Musculoskeletal; NMS-Builder; OpenSim; Sensitivity