title: Dantrolene an unusual option for detrusor overactivity: observations of a patient with cerebral palsy.
abstract: We report a case of a 49-year-old female with cerebral palsy with spastic tri-plegia and lumbar spondyolisthesis diagnosed to have overactive neurogenic bladder, which improved on treatment with Dantrolene along with antimuscarinics. She was initially treated with antimuscarinics both transdermal and oral simultaneously and later received intravesical OnaBotulinum toxinA. Following lumbar spine fixation for spondylolisthesis, her bowel and bladder function deteriorated and she was commenced on Dantrolene for her spasticity, along with being on Oxybutinin and Mirabegron. This significantly improved her symptoms. Overactive bladder symptoms are a common manifestation in cases of CP. In refractory cases where antimuscarinics and intravesical botulinum toxin therapy have failed, a combination of Dantrolene with antimuscarinics and/or beta 3 receptor agonists may prove to be beneficial. While on therapy, regular monitoring of liver functions is required to promptly diagnose and treat hepatotoxicity.
authors.affiliation: Birmingham Women's NHS Foundation Trust, Birmingham, UK. Electronic address: drsupriya73@yahoo.co.uk.
authors.forename: Supriya
authors.initials: S
authors.lastname: Bulchandani
authors.affiliation: Birmingham Women's NHS Foundation Trust, Birmingham, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Toozs-Hobson
authors.affiliation: Chelsea and Westminster Hospital, London, UK.
authors.forename: Angus
authors.initials: A
authors.lastname: Kennedy
authors.affiliation: Queen Elizabeth University Hospital, Birmingham, UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Sturman
mesh_terms: D002547:Cerebral Palsy / Q000150:complications*; D003620:Dantrolene / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D001750:Urinary Bladder, Neurogenic / Q000150:complications; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000209:etiology
chemical_list: D009125:Muscle Relaxants, Central; D003620:Dantrolene
keywords: Cerebral palsy; Dantrolene; Neurogenic bladder