title: A four-year follow-up controlled study of stress response and symptom persistence in Brazilian children and adolescents with attention deficit disorder and hyperactivity (ADHD).
abstract: This study evaluated children and adolescents with Attention Deficit Disorder andHyperactivity Disorder (ADHD), reassessing them at a four-year follow-up. Their cortisol response to a stress stimulus was measured twice. ADHD symptom persistence, development of comorbidities, and psychostimulant usage were also reassessed. The initial sample consisted of 38 ADHD patients and 38 healthy controls, age ranging 6-14. At the follow-up, there were 37 ADHD patients and 22 healthy controls, age ranging 10-18. ADHD was classified as persistent if the patients fulfilled all DSM IV criteria for syndromic or subthreshold or had functional impairment. Salivary cortisol samples were collected prior to the application of a cognitive stressor (Continuous Performance Test - CPT), and at three time intervals afterwards at baseline and at the follow-up. Their reassessment showed that 75% had persistent symptoms, psychiatric comorbidities (oppositional defiant and behavioral disorders), functional and academic impairement. Only seven patients were on medication. The ADHD group's cortisol levels were lower than those measured four years earlier, but cortisol concentrations were similar for both ADHD and control groups at the four-year follow-up. The cortisol results suggest that HPA axis reactivity could be a marker differentiating ADHD from ADHD with comorbidities.
authors.affiliation: Department of Psychobiology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Brazil.
authors.forename: Sonia Maria Motta
authors.initials: SM
authors.lastname: Palma
authors.affiliation: Universidade Mackenzie, São Paulo, Brazil.
authors.forename: Ana Carolina Motta Palma
authors.initials: AC
authors.lastname: Natale
authors.affiliation: Department of Psychobiology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Brazil. Electronic address: hmcalil@unifesp.br.
authors.forename: Helena Maria
authors.initials: HM
authors.lastname: Calil
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D011446:Prospective Studies; D012463:Saliva / Q000378:metabolism; D013315:Stress, Psychological / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D006854:Hydrocortisone
keywords: Comorbidity; Continuous performance test; Cortisol; Hypothalamic pituitary axis; Impulsivity; Inattention; Persistence