title: Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides.
abstract: An efficient one-pot approach for the synthesis of spiro[2.5]octa-4,7-dien-6-ones by employing para-quinone methides has been developed. The reaction proceeded smoothly in high yields under mild conditions without the use of metals. Moreover, all products obtained herein contained two or three consecutive quaternary centers.
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. ajlin@cpu.edu.cn hyao@cpu.edu.cn.
authors.forename: Kuo
authors.initials: K
authors.lastname: Gai
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. ajlin@cpu.edu.cn hyao@cpu.edu.cn.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Fang
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. ajlin@cpu.edu.cn hyao@cpu.edu.cn.
authors.forename: Xuanyi
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. ajlin@cpu.edu.cn hyao@cpu.edu.cn.
authors.forename: Jinyi
authors.initials: J
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. ajlin@cpu.edu.cn hyao@cpu.edu.cn.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. ajlin@cpu.edu.cn hyao@cpu.edu.cn.
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. ajlin@cpu.edu.cn hyao@cpu.edu.cn.
authors.forename: Hequan
authors.initials: H
authors.lastname: Yao
mesh_terms: D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D055772:Green Chemistry Technology; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003512:Cyclohexanones; D003521:Cyclopropanes; D013141:Spiro Compounds