title: [The multicenter non-interventional, prospective observational program on the study of practical use of teraligen in patients diagnosed with autonomic disorder (START2): a local Russian experience with the use of the Russian version of The Four-Dimensional Symptom Questionnaire (4DSQ). An intermediate analysis].
abstract: OBJECTIVE
  To develop a new instrument able to identify pathological states and assess their changes during medication treatment. We aimed to study the typical practice of using alimemazine (teraligen) in patients with the diagnosis of autonomic nervous system disorder and to test the Russian version of @The Four-Dimensional Symptom Questionnaire@ (4DSQ) for measuring distress, depression, anxiety and somatization.
  
  
  METHODS
  We examined 3053 patients (mean age 42.09 ± 11.71 years) who received teraligen in doses gradually increasing from 5 to 15 mg per day. The observational program was carried out in over 600 outpatient clinics of the Russian Federation. The 4DSQ was administered before treatment and 4 weeks after treatment. The Clinical Global Impression (CGI) scale was used before, during (after 2 weeks) and after (4 weeks) treatment with teraligen.
  
  
  CONCLUSIONS
  There was a significant improvement of patient's state assessed both by physicians (CGI scale) and by patients (96 and 98%, respectively). The 4DSQ was sensitive to the parameters of response to treatment with teraligen: parameters obtained at baseline and 4 weeks after the beginning of treatment differed significantly demonstrating a significant decrease in distress, anxiety and somatization.
authors.affiliation: Sechenov First Moscow State Medical University, Moscow.
authors.forename: N N
authors.initials: NN
authors.lastname: Yakhno
authors.affiliation: Sechenov First Moscow State Medical University, Moscow.
authors.forename: V A
authors.initials: VA
authors.lastname: Parfenov
authors.affiliation: Sechenov First Moscow State Medical University, Moscow.
authors.forename: D V
authors.initials: DV
authors.lastname: Reyhart
authors.affiliation: Sechenov First Moscow State Medical University, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Belostotsky
authors.affiliation: OAO Valenta Pharm, Moscow.
authors.forename: V S
authors.initials: VS
authors.lastname: Arnautov
mesh_terms: D000328:Adult; D001007:Anxiety / Q000175:diagnosis; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000523:psychology; D003863:Depression / Q000175:diagnosis; D011307:Drug Prescriptions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012426:Russia; D011795:Surveys and Questionnaires; D014291:Trimeprazine / Q000627:therapeutic use*
chemical_list: D014291:Trimeprazine