title: Short Communication: SCD14 and SCD163 Levels Are Correlated with VACS Index Scores: Initial Data from the Blunted Immune Recovery in CORE Patients with HIV (BIRCH) Cohort.
abstract: The relationship between markers of monocyte/macrophage activation (sCD14 and sCD163) and components of the Veterans Aging Cohort Study (VACS) score, which predict mortality in patients with HIV, in immunologic nonresponders (INRs) is not defined. HIV(+) subjects with >12 months of continuous virologic suppression and persistent CD4 <250 cells/mm(3) were enrolled at the CORE Center, Chicago. Subjects had a single visit where history was taken and blood drawn. ELISA assays for sCD14 and sC163 were performed at Blood Systems, CA. Descriptive statistics were performed using SAS. We enrolled 43 subjects with persistent CD4 <250 after a median of 32 months of continuous viral suppression. We found elevated markers of monocyte/macrophage activation; sCD14 and sCD163 correlated with higher VACS scores as well as hepatitis C virus (HCV) coinfection and FIB-4 score, components of the VACS index. In this cohort of immunologic nonresponders, there was a significant correlation between markers of monocyte/macrophage activation and the VACS score. Among components of the VACS index, we did not find a significant association between HCV coinfection and sCD14; however, there was a significant association between HCV coinfection and sCD163.
authors.affiliation: 1 Ruth Rothstein CORE Center, Cook County Health and Hospitals System , Chicago, Illinois.|2 Rush University Medical Center , Chicago, Illinois.|3 Developmental Center for AIDS Research , Chicago, Illinois.
authors.forename: Brett
authors.initials: B
authors.lastname: Williams
authors.affiliation: 3 Developmental Center for AIDS Research , Chicago, Illinois.|4 The University of Chicago , Chicago, Illinois.
authors.forename: Britt
authors.initials: B
authors.lastname: Livak
authors.affiliation: 1 Ruth Rothstein CORE Center, Cook County Health and Hospitals System , Chicago, Illinois.|3 Developmental Center for AIDS Research , Chicago, Illinois.
authors.forename: Mieaok
authors.initials: M
authors.lastname: Bahk
authors.affiliation: 5 Blood Systems Research Institute , San Francisco, California.
authors.forename: Sheila M
authors.initials: SM
authors.lastname: Keating
authors.affiliation: 1 Ruth Rothstein CORE Center, Cook County Health and Hospitals System , Chicago, Illinois.|2 Rush University Medical Center , Chicago, Illinois.|3 Developmental Center for AIDS Research , Chicago, Illinois.
authors.forename: Oluwatoyin M
authors.initials: OM
authors.lastname: Adeyemi
mesh_terms: D015703:Antigens, CD / Q000097:blood*; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D060085:Coinfection / Q000821:virology; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000276:immunology* / Q000401:mortality* / Q000821:virology; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000276:immunology* / Q000821:virology; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D011956:Receptors, Cell Surface / Q000097:blood*; D018570:Risk Assessment; D014728:Veterans; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D000098902:CD163 Antigen; D018950:Lipopolysaccharide Receptors; D011956:Receptors, Cell Surface