title: Association between CCDC132, FDX1 and TNFSF13 gene polymorphisms and the risk of IgA nephropathy.
abstract: OBJECTIVE
  Previous genome-wide association studies have identified multiple susceptibility loci for IgA nephropathy (IgAN); however, validation of these findings is still needed.
  
  
  METHODS
  We performed a case-control study among 347 Chinese Han IgAN patients and 310 ethnicity-matched controls. Twenty-two single nucleotide polymorphisms (SNPs) were genotyped and association analysis was performed.
  
  
  RESULTS
  We found three alleles for IgAN in patients: the allele "C" of rs2188404 in the CCDC132 gene by recessive model (odds ratio (OR), 1.65; 95% confidence interval (CI), 1.10-2.48; P = 0.014) and additive model (OR, 1.29; 95% CI, 1.03-1.61; P = 0.024) analysis, respectively, the allele "A" of rs10488764 in FDX1 gene by additive model (OR, 1.27; 95% CI, 1.00-1.61; P = 0.048) analysis, the allele "A" of rs3803800 in TNFSF13 gene by recessive model (OR, 2.05; 95% CI, 1.16-3.62; P = 0.010) and additive model (OR, 1.35; 95% CI, 1.06-1.72; P = 0.013) analysis, respectively. However, the associations between these SNPs and the risk of IgAN were not significant when adjusted for age and sex. Additionally, we found polymorphisms of rs2188404, rs10488764 and rs3803800 were correlated with urine protein (UPRO), human serum albumin (HSA), total cholesterol (TC) and Lee's pathological grades.
  
  
  CONCLUSIONS
  We did not find any positive association between these SNPs and the risk of IgAN after adjustment by age and sex, but did find a significant and strong correlation with relevant clinical pathological parameters. Our study may provide a new perspective to understanding the aetiology of IgAN.
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.|Forensic Medicine College, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Niu
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, Xi'an, Shaanxi, China.|School of Life Sciences, Northwest University, Xi'an, China.
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Liyi
authors.initials: L
authors.lastname: Xie
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Jiping
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Wanhong
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yaning
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Yin
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Huixian
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Lv
authors.affiliation: Forensic Medicine College, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Shengbin
authors.initials: S
authors.lastname: Li
mesh_terms: D000325:Adrenodoxin / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011507:Proteinuria / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis; D000075462:Serum Albumin, Human; D014157:Transcription Factors; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000235:genetics*; D055815:Young Adult
chemical_list: C422455:ALB protein, human; D015415:Biomarkers; D005819:Genetic Markers; D012709:Serum Albumin; C114631:TNFSF13 protein, human; D014157:Transcription Factors; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; C000598591:ZFC3H1 protein, human; D000325:Adrenodoxin; D002784:Cholesterol; D000075462:Serum Albumin, Human
keywords: CCDC132, FDX1, TNFSF13; IgA nephropathy; single nucleotide polymorphism (SNP)