title: Minocycline: a bacteriostatic antibiotic with pleiotropic cardioprotective effects.
abstract: Minocycline belongs to the family of tetracyclines, which are drugs traditionally approved as antibiotics. Based on preclinical animal cardiac models and clinical neurology trials, this drug has gained special attention as a promising cardiovascular therapeutic agent given its anti-inflammatory, antiapoptotic, antioxidant, and antienzymatic properties. This review focuses on the available evidence for minocycline as a cardioprotective drug, with special attention to mechanisms of action. Ongoing cardiovascular clinical trials are briefly discussed.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.|Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Brenes-Salazar
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects / Q000276:immunology; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008911:Minocycline / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D015394:Molecular Structure; D016032:Randomized Controlled Trials as Topic; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D002316:Cardiotonic Agents; D016207:Cytokines; D017382:Reactive Oxygen Species; D020782:Matrix Metalloproteinases; D008911:Minocycline
keywords: apoptose; apoptosis; cardio-protection; cardioprotection; ischemia; ischémie; lésion de reperfusion; minocycline; oxidative stress; reperfusion injury; stress oxydatif