title: Evaluation of bronchoscopic lung volume reduction coil treatment results in patients with severe emphysema.
abstract: BACKGROUND
  Bronchoscopic lung volume reduction coil (BLVR-C) implantation is an alternative therapeutic approach that can be applied together with medical treatment for patients with severe emphysema. BLVR-C is both easier and safer in terms of complications than volume reduction surgery. This study aimed to evaluate medium-term outcomes following BLVR-C treatment.
  
  
  METHODS
  Forty patients who underwent BLVR-C between September 2013 and March 2014 were reviewed retrospectively. We compared changes between the baseline and 6-month post-procedural results with respect to pulmonary function tests, a 6-min walk test (6MWT), chronic obstructive pulmonary disease (COPD) assessment test (CAT), St. George's Respiratory Questionnaire (SGRQ), and pulmonary artery pressure (PAP) and arterial blood gas analyses. Secondary outcomes included procedure-related and follow-up complications.
  
  
  RESULTS
  An average of 9.5 (range: 5-11) coils were placed per lung in an average procedural duration of 20.8 ± 7.0 min (range: 9-45) min. Six months after BLVR-C treatment, significant improvements were observed in patients' pulmonary function tests and quality of life. Changes were observed in the forced exhalation volume in 1 s (+150 mL), residual volume (-14.5%), 6MWT (+48 m), SGRQ (-10.5) and CAT Score (-7.5). Changes in the PAP and partial pressure of carbon dioxide values were not significant, and pneumothorax did not occur. In a 6-month follow-up, 11 cases of COPD exacerbation (41.4%), 7 cases of pneumonia (16.9%) and 1 death (2%) occurred. Treatment in 1 case was postponed because of hypotension and bradycardia during the process.
  
  
  CONCLUSIONS
  BLVR-C treatment appears to be effective over the medium-term and safe for patients with severe emphysema.
authors.affiliation: Department of Pulmonary Diseases, Sifa University Medical Faculty, Izmir, Turkey.
authors.forename: Askin
authors.initials: A
authors.lastname: Gulsen
authors.affiliation: Department of Pulmonary Diseases, Sifa University Medical Faculty, Izmir, Turkey.
authors.forename: Fidan
authors.initials: F
authors.lastname: Sever
authors.affiliation: Department of Anesthesiology, Sifa University Medical Faculty, Izmir, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Girgin
authors.affiliation: Department of Cardiology, Sifa University Medical Faculty, Izmir, Turkey.
authors.forename: Necdet Batuhan
authors.initials: NB
authors.lastname: Tamci
authors.affiliation: Department of İnternal Medicine, Sifa University Medical Faculty, Izmir, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Yilmaz
mesh_terms: D000368:Aged; D001999:Bronchoscopy / Q000009:adverse effects* / Q000295:instrumentation* / Q000379:methods; D004646:Emphysema / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000295:instrumentation* / Q000379:methods; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging / Q000601:surgery*; D011788:Quality of Life; D012115:Residual Volume / Q000502:physiology; D012129:Respiratory Function Tests / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome; D000070857:Walk Test / Q000379:methods
keywords: bronchoscopy - chronic obstructive lung disease - coil - emphysema - lung volume reduction