title: Neurobiological Models of Self-Disorders in Early Schizophrenia.
abstract: Self-disorders (SDs) (from the German Ichstörungen) are alterations of the first-person perspective, long associated with schizophrenia, particularly in early phases. Although psychopathological features of SDs continue to be studied, their neurobiological underpinnings are unknown. This makes it difficult to integrate SDs into contemporary models of psychosis. The present review aims to address this issue, starting from an historical excursus revealing an interconnection between neuroscientific models and the origin of the psychopathological concept of SDs. Subsequently, the more recent neurobiological models related to SDs are discussed, particularly with respect to the onset of schizophrenia.
authors.affiliation: Department of Clinical Psychology, Chicago School of Professional Psychology, Southern California Campus, Los Angeles, CA;
authors.forename: A
authors.initials: A
authors.lastname: Mishara
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College of London, London, UK; OASIS service, South London and the Maudsley NHS Foundation Trust, London, UK; Department of Brain and Behavioural Sciences, University of Pavia, Italy; ilaria.bonoldi@kcl.ac.uk.
authors.forename: I
authors.initials: I
authors.lastname: Bonoldi
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College of London, London, UK; Department of Psychology, University of Roehampton, Whitgelands College, London, UK;
authors.forename: P
authors.initials: P
authors.lastname: Allen
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College of London, London, UK; Department of Clinical and Experimental Medicine, University of Pisa, Italy;
authors.forename: G
authors.initials: G
authors.lastname: Rutigliano
authors.affiliation: CAMEO Early Intervention Services, Fulbourn Hospital, Fulbourn, Cambridge, UK; Department of Psychiatry, Cambridge University, Cambridge, UK.
authors.forename: J
authors.initials: J
authors.lastname: Perez
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College of London, London, UK; OASIS service, South London and the Maudsley NHS Foundation Trust, London, UK; Department of Brain and Behavioural Sciences, University of Pavia, Italy;
authors.forename: P
authors.initials: P
authors.lastname: Fusar-Poli
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College of London, London, UK;
authors.forename: P
authors.initials: P
authors.lastname: McGuire
mesh_terms: D006801:Humans; D008954:Models, Biological; D012559:Schizophrenia / Q000503:physiopathology*; D012649:Self Concept
keywords: Bayesian modeling; Gruhle; Heidelberg mescaline study; Mayer-Gross; aberrant salience; neuroimaging; phenomenology; prodromal; psychosis; schizophrenia; self-disorders