title: Expression of prokineticin-receptor2(PK-R2) is a new prognostic factor in human colorectal cancer.
abstract: The increased invasiveness of colorectal cancer cells is important for progression and metastasis to the surrounding organs. According to recent molecular biological studies, signaling through transmembrane Prokineticin-Receptor2(PK-R2) is likely involved in the ability of tumor cell to invade. However, no studies have evaluated the relationship between PK-R2 expression, ability of cancer to invade/metastasize, and patient prognosis in cases of resected colorectal cancer. Accordingly, we have examined these factors in the present study.Immunohistochemical staining was performed to detect PK-R2 in the primary lesion and adjacent normal large intestine mucosa of 324 colorectal cancer patients who underwent resection surgery at our department. Additionally, we conducted clinicopathologic examinations and analyzed patient prognoses with the Kaplan-Meier method. Further, multivariate analysis was conducted using a cox-proportional hazard model.PK-R2 expression was observed on the cellular membrane of the primary lesion in 147 of 324 cases (45.3%) of human colorectal cancer. PK-R2 expression was associated with a higher incidence of vascular invasion, lymph node metastasis, hepatic metastasis, and hematogenous metastasis. Further, prevalence of PK-R2 expression increased as tumor stage increased. In stage III curative resection cases, where recurrence is the most serious problem, cases that expressed PK-R2 had a significantly lower 5-year survival rate (82.1% versus 66.8%) and higher recurrence compared to those cases with no PK-R2 expression. In the multivariate analysis for prognosis, PK-R2 expression was found to be an independent factor(ratio2.621).PK-R2 expression could be one of the new prognostic factors in human colorectal cancer.
authors.affiliation: First Department of Surgery, University of Fukui, Fukui, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Goi
authors.affiliation: First Department of Surgery, University of Fukui, Fukui, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Kurebayashi
authors.affiliation: First Department of Surgery, University of Fukui, Fukui, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ueda
authors.affiliation: First Department of Surgery, University of Fukui, Fukui, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Naruse
authors.affiliation: First Department of Surgery, University of Fukui, Fukui, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nakazawa
authors.affiliation: First Department of Surgery, University of Fukui, Fukui, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Koneri
authors.affiliation: First Department of Surgery, University of Fukui, Fukui, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hirono
authors.affiliation: First Department of Surgery, University of Fukui, Fukui, Japan.
authors.forename: Kanji
authors.initials: K
authors.lastname: Katayama
authors.affiliation: First Department of Surgery, University of Fukui, Fukui, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Yamaguchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007420:Intestine, Large / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000378:metabolism / Q000401:mortality / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000556:secondary*; D011379:Prognosis; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism*; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C470838:PROKR2 protein, human; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide
keywords: colorectal cancer; prognostic factor; prokineticin-receptor2