title: Evaluation of ventricular dysfunction using semi-automatic longitudinal strain analysis of four-chamber cine MR imaging.
abstract: The aim of this study was to evaluate ventricular dysfunction using the longitudinal strain analysis in 4-chamber (4CH) cine MR imaging, and to investigate the agreement between the semi-automatic and manual measurements in the analysis. Fifty-two consecutive patients with ischemic, or non-ischemic cardiomyopathy and repaired tetralogy of Fallot who underwent cardiac MR examination incorporating cine MR imaging were retrospectively enrolled. The LV and RV longitudinal strain values were obtained by semi-automatically and manually. Receiver operating characteristic (ROC) analysis was performed to determine the optimal cutoff of the minimum longitudinal strain value for the detection of patients with cardiac dysfunction. The correlations between manual and semi-automatic measurements for LV and RV walls were analyzed by Pearson coefficient analysis. ROC analysis demonstrated the optimal cut-off of the minimum longitudinal strain values (εL_min) for diagnoses the LV and RV dysfunction at a high accuracy (LV εL_min = -7.8 %: area under the curve, 0.89; sensitivity, 83 %; specificity, 91 %, RV εL_min = -15.7 %: area under the curve, 0.82; sensitivity, 92 %; specificity, 68 %). Excellent correlations between manual and semi-automatic measurements for LV and RV free wall were observed (LV, r = 0.97, p < 0.01; RV, r = 0.79, p < 0.01). Our semi-automatic longitudinal strain analysis in 4CH cine MR imaging can evaluate LV and RV dysfunction with simply and easy measurements. The strain analysis could have extensive application in cardiac imaging for various clinical cases.
authors.affiliation: Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan. kawakubo@fmt.teikyo-u.ac.jp.|Department of Radiological Technology, Faculty of Fukuoka Medical Technology, Teikyo University, 6-22 Misaki-machi Omuta-city, Fukuoka, 836-0037, Japan. kawakubo@fmt.teikyo-u.ac.jp.
authors.forename: Masateru
authors.initials: M
authors.lastname: Kawakubo
authors.affiliation: Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Michinobu
authors.initials: M
authors.lastname: Nagao
authors.affiliation: Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.|Department of Radiological Technology, Faculty of Health Sciences, Hokkaido University of Science, Sapporo, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kumazawa
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yamasaki
authors.affiliation: Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Akiko S
authors.initials: AS
authors.lastname: Chishaki
authors.affiliation: Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
authors.affiliation: Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Morishita
mesh_terms: D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D018754:Ventricular Dysfunction / Q000503:physiopathology*
keywords: Cine magnetic resonance imaging; Feature tracking; Left ventricular ejection fraction; Right ventricular ejection fraction; Semi-automatic longitudinal strain analysis