title: Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus.
abstract: Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.
authors.affiliation: Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, United States.
authors.forename: Carl D
authors.initials: CD
authors.lastname: Langefeld
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; US Department of Veterans Affairs Medical Center, Cincinnati, OH, United States.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Kaufman
authors.affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Kelly
authors.affiliation: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Bae
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
authors.forename: Graciela S
authors.initials: GS
authors.lastname: Alarcón
authors.affiliation: Center for Autoimmune Diseases Research, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Juan-Manuel
authors.initials: JM
authors.lastname: Anaya
authors.affiliation: Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA, United States.
authors.forename: Lindsey A
authors.initials: LA
authors.lastname: Criswell
authors.affiliation: Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.
authors.forename: Barry I
authors.initials: BI
authors.lastname: Freedman
authors.affiliation: Medical University of South Carolina, Charleston, SC, United States.
authors.forename: Diane L
authors.initials: DL
authors.lastname: Kamen
authors.affiliation: Medical University of South Carolina, Charleston, SC, United States.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Gilkeson
authors.affiliation: Department of Medicine, University of Southern California, Los Angeles, CA, United States.
authors.forename: Chaim O
authors.initials: CO
authors.lastname: Jacob
authors.affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
authors.forename: Judith A
authors.initials: JA
authors.lastname: James
authors.affiliation: Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
authors.forename: Joan T
authors.initials: JT
authors.lastname: Merrill
authors.affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Gaffney
authors.affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
authors.forename: Kathy Moser
authors.initials: KM
authors.lastname: Sivils
authors.affiliation: Department of Immunology, Mayo Clinic, Rochester, MN, United States.
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Niewold
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Petri
authors.affiliation: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
authors.forename: Seung Taek
authors.initials: ST
authors.lastname: Song
authors.affiliation: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Jeong
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
authors.forename: Rosalind
authors.initials: R
authors.lastname: Ramsey-Goldman
authors.affiliation: Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX, United States.
authors.forename: John D
authors.initials: JD
authors.lastname: Reveille
authors.affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, United States.
authors.forename: R Hal
authors.initials: RH
authors.lastname: Scofield
authors.affiliation: Department of Pediatrics, University of Washington, Seattle, WA, United States; Center for Immunity and Immunotherapies, Seattle Children's Research Institute Seattle, WA, United States.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Stevens
authors.affiliation: University of Colorado School of Medicine, Aurora, CO, United States; US Department of Veterans Affairs Medical Center, Denver, CO, United States.
authors.forename: Susan A
authors.initials: SA
authors.lastname: Boackle
authors.affiliation: Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Vilá
authors.affiliation: National Defense Medical Center, Taipei City, Taiwan.
authors.forename: Deh-Ming
authors.initials: DM
authors.lastname: Chang
authors.affiliation: Seoul National University, Seoul, South Korea.
authors.forename: Yeong Wook
authors.initials: YW
authors.lastname: Song
authors.affiliation: King's College London, London, UK.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Vyse
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; US Department of Veterans Affairs Medical Center, Cincinnati, OH, United States.
authors.forename: John B
authors.initials: JB
authors.lastname: Harley
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United States.
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Brown
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Edberg
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Kimberly
authors.affiliation: Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
authors.forename: Bevra H
authors.initials: BH
authors.lastname: Hahn
authors.affiliation: Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Grossman
authors.affiliation: Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States. Electronic address: btsao@mednet.ucla.edu.
authors.forename: Betty P
authors.initials: BP
authors.lastname: Tsao
authors.affiliation: Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States. Electronic address: alacava@mednet.ucla.edu.
authors.forename: Antonio
authors.initials: A
authors.lastname: La Cava
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020738:Leptin / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D020738:Leptin
keywords: Gene polymorphisms; Leptin pathway; Systemic lupus erythematosus