title: Ultrasound-guided transversus abdominis plane block in patients undergoing open inguinal hernia repair: 0.125% bupivacaine provides similar analgesic effect compared to 0.25% bupivacaine.
abstract: OBJECTIVE
  To evaluate the effectiveness of 0.125% bupivacaine compared to 0.25% bupivacaine for ultrasound-guided transversus abdominis plane (TAP) block in patients undergoing open inguinal hernia repair.
  
  
  METHODS
  Randomized, double-blind study.
  
  
  METHODS
  Educational and research hospital.
  
  
  METHODS
  Forty adult patients of American Society of Anesthesiologists physical status I-III undergoing elective primary unilateral open inguinal hernia repair under spinal anesthesia.
  
  
  METHODS
  Patients in group I received 20 mL of 0.25% bupivacaine, whereas patients in group II received 20 mL of 0.125% bupivacaine for TAP block at the end of the surgery.
  
  
  METHODS
  Pain intensity was assessed at rest and during coughing using 10-cm visual analog scale score at 5, 15, 30, and 45 minutes and 1, 2, 4, 6, 12, and 24 hours after TAP block. Morphine consumption and time to first morphine requirement were recorded.
  
  
  RESULTS
  Visual analog scale scores at rest and during coughing were not significantly different between groups at all time points measured. Twenty-four hours of morphine consumption (7.72±7.33 mg in group I and 6.06±5.20 mg in group II; P=.437) and time to first morphine requirement (182.35±125.16 minutes in group I and 143.21±87.28 minutes in group II; P=.332) were not different between groups.
  
  
  CONCLUSIONS
  0.125% Bupivacaine provides similar analgesic effect compared to 0.25% bupivacaine for ultrasound-guided TAP block in patients undergoing open inguinal hernia repair.
authors.affiliation: Anesthesiology and Reanimation Department, Fatih Sultan Mehmet Educational and Research Hospital, Istanbul, Turkey. Electronic address: dilekerdoganari@gmail.com.
authors.forename: Dilek
authors.initials: D
authors.lastname: Erdoğan Arı
authors.affiliation: Anesthesiology and Reanimation Department, Fatih Sultan Mehmet Educational and Research Hospital, Istanbul, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Yıldırım Ar
authors.affiliation: Anesthesiology and Reanimation Department, Fatih Sultan Mehmet Educational and Research Hospital, Istanbul, Turkey.
authors.forename: Firdevs
authors.initials: F
authors.lastname: Karadoğan
authors.affiliation: General Surgery Department, Fatih Sultan Mehmet Educational and Research Hospital, Istanbul, Turkey.
authors.forename: Yetkin
authors.initials: Y
authors.lastname: Özcabı
authors.affiliation: Anesthesiology and Reanimation Department, Fatih Sultan Mehmet Educational and Research Hospital, Istanbul, Turkey.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Koçoğlu
authors.affiliation: General Surgery Department, Fatih Sultan Mehmet Educational and Research Hospital, Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Kılıç
authors.affiliation: Anesthesiology and Reanimation Department, Fatih Sultan Mehmet Educational and Research Hospital, Istanbul, Turkey.
authors.forename: Fatma Nur
authors.initials: FN
authors.lastname: Akgün
mesh_terms: D000009:Abdominal Muscles / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000775:Anesthesia, Spinal / Q000379:methods; D000779:Anesthetics, Local / Q000008:administration & dosage; D002045:Bupivacaine / Q000008:administration & dosage; D004311:Double-Blind Method; D017558:Elective Surgical Procedures; D005260:Female; D006552:Hernia, Inguinal / Q000601:surgery*; D059685:Herniorrhaphy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D009407:Nerve Block / Q000379:methods*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D009020:Morphine; D002045:Bupivacaine
keywords: Bupivacaine; Open inguinal hernia repair; Postoperative analgesia; Transversus abdominis plane block