title: Hepatoprotective phenylethanoid glycosides from Cirsium setosum.
abstract: Two new phenylethanoid glycosides, namely β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(3-methoxyl-4-hydroxyphenyl)-8-propenoate] (1) and β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(4-hydroxyphenyl)-8-propenoate] (2), together with six phenylethanoid glycosides were isolated from Cirsium setosum. Their structures were elucidated by their spectroscopic data and references. Compounds 2, 4, 5, 7 and 8 (10 μM) exhibited moderate hepatoprotective activities. Compounds (3-8) were obtained from this plant for the first time.
authors.affiliation: a Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , China.
authors.forename: Qinge
authors.initials: Q
authors.lastname: Ma
authors.affiliation: a Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Guo
authors.affiliation: a Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , China.
authors.forename: Baomin
authors.initials: B
authors.lastname: Luo
authors.affiliation: a Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , China.
authors.forename: Wenmin
authors.initials: W
authors.lastname: Liu
authors.affiliation: b Department of Pharmacology, College of Pharmacy , China Pharmaceutical University , Nanjing , China.
authors.forename: Rongrui
authors.initials: R
authors.lastname: Wei
authors.affiliation: a Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Yang
authors.affiliation: a Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , China.
authors.forename: Chenghua
authors.initials: C
authors.lastname: Ding
authors.affiliation: a Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Xu
authors.affiliation: a Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , China.
authors.forename: Minghui
authors.initials: M
authors.lastname: He
mesh_terms: D000818:Animals; D031180:Cirsium / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D008099:Liver / Q000187:drug effects; D015394:Molecular Structure; D020011:Protective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D006027:Glycosides; D020011:Protective Agents
keywords: Cirsium setosum; hepatoprotective activity; phenylethanoid glycoside