title: Preparation of Dental Resins Resistant to Enzymatic and Hydrolytic Degradation in Oral Environments.
abstract: The short average service life of traditional dental composite restorative materials and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting compositions. Novel monomers and their polymers, reinforcing fillers, and adhesive components are needed. The goal of this research is to develop resin systems for use in restorations, sealants, and other dental services that are superior in properties and endurance to currently used bisphenol A glycidyl dimethacrylate/triethylene glycol dimethacrylate (Bis-GMA/TEGDMA) and urethane-dimethacrylate products. Ether-based monomers and their polymers that were not susceptible to enzymatic or hydrolytic degradation were prepared and characterized. They showed no degradation under hydrolytic and enzymatic challenges, whereas the hydrolysis of ester links weakened contemporary resins within 16 days under these challenges. The success of the ether-based materials is promising in making durable systems that are subjected to long-term biochemical and hydrolytic challenges in oral environments.
authors.affiliation: Dr. Anthony Volpe Research Center, American Dental Association Foundation, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
authors.forename: Andres
authors.initials: A
authors.lastname: Gonzalez-Bonet
authors.affiliation: Dr. Anthony Volpe Research Center, American Dental Association Foundation, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
authors.forename: Gili
authors.initials: G
authors.lastname: Kaufman
authors.affiliation: Dr. Anthony Volpe Research Center, American Dental Association Foundation, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
authors.forename: Yin
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Dr. Anthony Volpe Research Center, American Dental Association Foundation, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
authors.forename: Christopher
authors.initials: C
authors.lastname: Wong
authors.affiliation: Dr. Anthony Volpe Research Center, American Dental Association Foundation, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
authors.forename: Abigail
authors.initials: A
authors.lastname: Jackson
authors.affiliation: Dr. Anthony Volpe Research Center, American Dental Association Foundation, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
authors.forename: George
authors.initials: G
authors.lastname: Huyang
authors.affiliation: Dr. Anthony Volpe Research Center, American Dental Association Foundation, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
authors.forename: Rafael
authors.initials: R
authors.lastname: Bowen
authors.affiliation: Dr. Anthony Volpe Research Center, American Dental Association Foundation, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
authors.forename: Jirun
authors.initials: J
authors.lastname: Sun
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003188:Composite Resins; D004798:Enzymes / Q000378:metabolism*; D006868:Hydrolysis; D009055:Mouth / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D003188:Composite Resins; D004798:Enzymes