title: Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction.
abstract: Apolipoprotein E (ApoE) is a plasma protein and associated with cholesterol transport system. In several studies, the relationship between ApoE gene polymorphism and severity of coronary artery disease (CAD) has been shown. However, the relationship between ApoE gene polymorphism and severity of CAD in patients with acute myocardial infarction (MI) has not been well known. The aim of this study is to investigate the relation between ApoE polymorphism and severity of CAD in patients with acute MI by using the Gensini Score. In this study, 138 patients were admitted to cardiology clinic with diagnosis of acute MI, and angiographic assessment was performed using the Gensini Score. Blood samples were obtained from all patients in the first day. The patients with ApoE34 genotype had high Gensini scores. Besides, the patients with E4 allele carriers were associated with high Gensini score compared with the patients without E4 allele carriers (p:0,22). The patients with E4 allele carriers were associated with higher LDL cholesterol and total cholesterol compared with the patients without E4 allele carriers (p:0,001 and p:0,03, resp.). There were no statistically significant differences between ApoE genotypes and severity of CAD by using the Gensini Score. But, the patients with E4 allele carriers were associated with high lipid levels.
authors.affiliation: Cardiology, Gazi Yasargil Education and Research Hospital, 21070 Diyarbakır, Turkey.
authors.forename: Zülküf
authors.initials: Z
authors.lastname: Karahan
authors.affiliation: Cardiology, Gazi Yasargil Education and Research Hospital, 21070 Diyarbakır, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Uğurlu
authors.affiliation: Cardiology, Gazi Yasargil Education and Research Hospital, 21070 Diyarbakır, Turkey.
authors.forename: Berzal
authors.initials: B
authors.lastname: Uçaman
authors.affiliation: Cardiology, Gazi Yasargil Education and Research Hospital, 21070 Diyarbakır, Turkey.
authors.forename: Ali Veysel
authors.initials: AV
authors.lastname: Uluğ
authors.affiliation: Cardiology, Gazi Yasargil Education and Research Hospital, 21070 Diyarbakır, Turkey.
authors.forename: İlyas
authors.initials: İ
authors.lastname: Kaya
authors.affiliation: Cardiology, Gazi Yasargil Education and Research Hospital, 21070 Diyarbakır, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Çevik
authors.affiliation: Cardiology, Gazi Yasargil Education and Research Hospital, 21070 Diyarbakır, Turkey.
authors.forename: Önder
authors.initials: Ö
authors.lastname: Öztürk
authors.affiliation: Cardiovascular Surgery, Gazi Yasargil Education and Research Hospital, 21070 Diyarbakır, Turkey.
authors.forename: Hikmet
authors.initials: H
authors.lastname: Iyem