title: Oxygen tension, H2S, and NO bioavailability: is there an interaction?
abstract: Molecular oxygen (O2) is an essential component for survival and development. Variation in O2 levels leads to changes in molecular signaling and ultimately affects the physiological functions of many organisms. Nitric oxide (NO) and hydrogen sulfide (H2S) are two gaseous cellular signaling molecules that play key roles in several physiological functions involved in maintaining vascular homeostasis including vasodilation, anti-inflammation, and vascular growth. Apart from the aforementioned functions, NO and H2S are believed to mediate hypoxic responses and serve as O2 chemosensors in biological systems. In this literature review, we briefly discuss NO and H2S and their roles during hypoxia.
authors.affiliation: Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana; and.
authors.forename: Gopi K
authors.initials: GK
authors.lastname: Kolluru
authors.affiliation: Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
authors.forename: Priya K
authors.initials: PK
authors.lastname: Prasai
authors.affiliation: Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
authors.forename: Amir M
authors.initials: AM
authors.lastname: Kaskas
authors.affiliation: Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
authors.forename: Vijay
authors.initials: V
authors.lastname: Letchuman
authors.affiliation: Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana cpatt7@lsuhsc.edu.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Pattillo
mesh_terms: D000818:Animals; D001682:Biological Availability; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide; D010100:Oxygen; D006862:Hydrogen Sulfide
keywords: cardiovascular; hydrogen sulfide; hypoxia; nitric oxide; oxygen