title: Sexual health in hematopoietic stem cell transplant recipients.
abstract: Hematopoietic stem cell transplantation (HSCT) plays a central role in patients with malignant and, increasingly, nonmalignant conditions. As the number of transplants increases and the survival rate improves, long-term complications are important to recognize and treat to maintain quality of life. Sexual dysfunction is a commonly described but relatively often underestimated complication after HSCT. Conditioning regimens, generalized or genital graft-versus-host disease, medications, and cardiovascular complications as well as psychosocial problems are known to contribute significantly to physical and psychological sexual dysfunction. Moreover, it is often a difficult topic for patients, their significant others, and health care providers to discuss. Early recognition and management of sexual dysfunction after HSCT can lead to improved quality of life and outcomes for patients and their partners. This review focuses on the risk factors for and treatment of sexual dysfunction after transplantation and provides guidance concerning how to approach and manage a patient with sexual dysfunction after HSCT.
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Zhuoyan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Hematology, Western Pennsylvania Cancer Institute, Pittsburgh, Pennsylvania.
authors.forename: Prerna
authors.initials: P
authors.lastname: Mewawalla
authors.affiliation: Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
authors.forename: Pamela
authors.initials: P
authors.lastname: Stratton
authors.affiliation: Department of Haematology, SA Pathology, and School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Agnes S M
authors.initials: AS
authors.lastname: Yong
authors.affiliation: Center for International Blood and Marrow Transplant Research, Froedtert and the Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Bronwen E
authors.initials: BE
authors.lastname: Shaw
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Shahrukh
authors.initials: S
authors.lastname: Hashmi
authors.affiliation: Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, Tennessee.
authors.forename: Madan
authors.initials: M
authors.lastname: Jagasia
authors.affiliation: INSERM (National Institute of Health and Medical Research) 938, Paris, France.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Blood and Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Navneet S
authors.initials: NS
authors.lastname: Majhail
authors.affiliation: Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, Tennessee.
authors.forename: Bipin N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Department of Hematology, University Hospital of Bern, Bern, Switzerland.
authors.forename: Alicia
authors.initials: A
authors.lastname: Rovó
mesh_terms: D019468:Disease Management; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D006282:Health Personnel; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D011788:Quality of Life; D060728:Reproductive Health; D012307:Risk Factors; D012735:Sexual Dysfunction, Physiological / Q000209:etiology / Q000523:psychology* / Q000628:therapy; D020018:Sexual Dysfunctions, Psychological / Q000209:etiology / Q000523:psychology* / Q000628:therapy; D018454:Spouses / Q000523:psychology; D019172:Transplantation Conditioning / Q000009:adverse effects*
keywords: late effects; sexual health; survivorship; toxicity; transplantation