title: Responsiveness, Minimal Detectable Change, and Minimally Clinically Important Differences for the Disorders of Consciousness Scale.
abstract: To determine the responsiveness, minimal detectable change (MDC95), and minimally clinically important difference (MCID) of the Disorders of Consciousness Scale (DOCS-25) in patients with severe traumatic brain injury (TBI) and to report the percentages of patients' change scores exceeding MDC and MCID after 3 weeks of inpatient rehabilitation.
  
  
  
  Post-acute rehabilitation hospitals.
  
  
  
  One hundred seventy-two patients with severe TBI. Ninety-two were included in the DOCS-25 3-week analysis.
  
  
  
  Retrospective cohort study.
  
  
  
  Disorders of Consciousness Scale, Glasgow Coma Scale.
  
  
  
  The effect size and standardized response mean of the DOCS-25 for those who improved were 0.45 and 1.3, respectively-moderate to large by Cohen criteria. The MDC95 (95% confidence interval) was 5.6. Distribution-based MCIDs for small (0.20 SD), moderate (0.33 SD), and large (0.50 SD) differences were 2.6 units, 4.4 units, and 6.6 units, respectively. The anchor-based MCID was 8.6 units. On average, patients who improved (n = 57) gained 14.5 units by week 3, exceeding the anchor-based MCID. On average, patients who did not improve (n = 35) declined by 7.2 units, which exceeds both the MDC95 and the largest distribution-based MCID.
  
  
  
  The DOCS-25 is a responsive, clinician-observed assessment tool for capturing change in neurobehavioral function in adults recovering from severe TBI. This is the first study to provide evidence for the size of neurobehavioral function change that might indicate meaningful recovery in patients with severe TBI. Results from this study may support future research by better informing sample size calculations for clinical trials and also assist clinicians in identifying when variation in level of consciousness is consequential enough to warrant changes in intervention.
authors.affiliation: The School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia (Dr Mallinson); The Department of Veterans Affairs Hines VA Hospital, Research Service and the Center for Innovation in Complex Chronic Healthcare & Research Service, Hines, Illinois (Dr Pape and Ms Guernon); Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, Illinois (Dr Pape); and Marianjoy Rehabilitation Hospital, Research Department, Wheaton, Illinois (Ms Guernon).
authors.forename: Trudy
authors.initials: T
authors.lastname: Mallinson
authors.forename: Theresa Louise-Bender
authors.initials: TL
authors.lastname: Pape
authors.forename: Ann
authors.initials: A
authors.lastname: Guernon
mesh_terms: D000328:Adult; D000070642:Brain Injuries, Traumatic / Q000175:diagnosis / Q000503:physiopathology*; D003244:Consciousness Disorders / Q000175:diagnosis*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D055815:Young Adult