title: Biological therapy and dentistry: a review paper.
abstract: In recent years, a new class of drugs has revolutionized the treatment of autoimmune, allergic, infectious, and many more diseases. This new class of drugs is made of 3 groups-cytokines, monoclonal antibodies, and fusion proteins-that may target special damaged cells but not all the cells. These drugs may have side effects such as infection, hypersensitivity, hematologic disorders, cancer, hepatotoxicity, and neurologic disorders. However, there is not enough evidence or long-term studies of the mechanism of action and side effects of these drugs. Patients receiving biological therapies may need special consideration in dentistry. This paper is a review of the classification, mechanism of action, and side effects of these drugs and dental consideration for patients receiving biological therapies.
authors.affiliation: College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address: Lida-radfar@ouhsc.edu.
authors.forename: Lida
authors.initials: L
authors.lastname: Radfar
authors.affiliation: College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
authors.forename: Roshanak E
authors.initials: RE
authors.lastname: Ahmadabadi
authors.affiliation: College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
authors.forename: Farah
authors.initials: F
authors.lastname: Masood
authors.affiliation: Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma.
authors.forename: R Hal
authors.initials: RH
authors.lastname: Scofield
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001691:Biological Therapy / Q000009:adverse effects / Q000639:trends*; D016207:Cytokines / Q000627:therapeutic use; D017742:Dental Care for Chronically Ill / Q000639:trends*; D006801:Humans
chemical_list: D000911:Antibodies, Monoclonal; D016207:Cytokines