title: Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death.
abstract: The success of Mycobacterium tuberculosis as a human pathogen has been attributed to the ability of the bacillus to proliferate inside macrophages and to induce cell death. This review describes how the sensors of the innate immune system modulate the cell death pathways in infected macrophages and, consequently, the pathogenesis of tuberculosis.
authors.affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: eduardoamaral@usp.br.
authors.forename: Eduardo P
authors.initials: EP
authors.lastname: Amaral
authors.affiliation: Laboratory of Recognition Biology, Center of Biosciences and Biotechnology, State University of North Fluminense, Campos dos Goytacazes, Rio de Janeiro, Brazil.
authors.forename: Elena B
authors.initials: EB
authors.lastname: Lasunskaia
authors.affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: relima@usp.br.
authors.forename: Maria Regina
authors.initials: MR
authors.lastname: D'Império-Lima
mesh_terms: D016923:Cell Death; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology* / Q000502:physiology*; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000472:pathogenicity*; D014376:Tuberculosis / Q000473:pathology*
keywords: Cell death; Danger signal; Inflammatory mediators; Innate immune sensors; Mycobacteria