title: Aplastic anemia associated with pregnancy: maternal and fetal complications.
abstract: OBJECTIVE
  To analyze obstetric complications associated with aplastic anemia (AA) among pregnant women and analyze the underlying factors.
  
  
  METHODS
  A retrospective analysis of 60 pregnancies with AA. Thirty four of these patients were grouped as complicated group having obstetric complications and the rest 26 without complications as the control group. Comparative analysis was conducted to access the related risk factors, which may affect the maternal and fetal complications.
  
  
  RESULTS
  The major maternal complications in this study were premature labor, gestational diabetes, pre-eclampsia, acute heart failure, postpartum hemorrhage, and severe postpartum infection. Premature birth, fetal growth restriction and stillbirths accounted for 27.3%, 5.0% and 6.7% of prenatal mortality. Twenty six of patients had uncomplicated pregnancies. Patients without complications had higher mean hemoglobin concentration (75.38 ± 16.19 g/L) and platelet counts (23.92 ± 14.82 × 10(9) cells/L) than did women with complications (mean hemoglobin concentration, 61.47 ± 15.15 g/L, p = 0.001; mean platelet counts, 12.11 ± 7.87 × 10(9) cells/L, p < 0.001).
  
  
  CONCLUSIONS
  Pregnancies associated with AA can carry the risk of multiple maternal and fetal complications. Low hemoglobin concentration and platelet counts may be the primary risk factors for obstetric complications in pregnancies associated with AA.
authors.affiliation: a Department of Obstetrics and Gynecology , Peking University People's Hospital , Beijing , China.
authors.forename: Li
authors.initials: L
authors.lastname: Bo
authors.affiliation: a Department of Obstetrics and Gynecology , Peking University People's Hospital , Beijing , China.
authors.forename: Liang
authors.initials: L
authors.lastname: Mei-Ying
authors.affiliation: a Department of Obstetrics and Gynecology , Peking University People's Hospital , Beijing , China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yang
authors.affiliation: a Department of Obstetrics and Gynecology , Peking University People's Hospital , Beijing , China.
authors.forename: Wang
authors.initials: W
authors.lastname: Shan-Mi
authors.affiliation: a Department of Obstetrics and Gynecology , Peking University People's Hospital , Beijing , China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xiao-Hong
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000453:epidemiology*; D036861:Delivery, Obstetric / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology; D007744:Obstetric Labor Complications / Q000453:epidemiology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011644:Puerperal Disorders / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Aplastic anemia; maternal and fetal complications; risk factor