title: A randomized trial of direct pulp capping in primary molars using MTA compared to 3Mixtatin: a novel pulp capping biomaterial.
abstract: OBJECTIVE
  This study aimed to examine the efficacy of 3Mixtatin (a combination of simvastatin and 3Mix antibiotic) as a novel pulp capping biomaterial in DPC of human primary molars.
  
  
  METHODS
  In this randomized clinical trial, 160 primary molars from 83 healthy children aged 3-6 years were randomly allocated into four groups. Small traumatic non-caries pulpal exposures were treated by DPC using simvastatin, 3Mix, 3Mixtatin, or MTA. Capping materials were covered with hard-setting zinc oxide eugenol (ZOE) cement, and then, teeth were restored with amalgam. Clinical and radiographic examinations were conducted at 2, 6, and 12 months after treatment. The data were compared using chi-square test at a significance level of 0.05.
  
  
  RESULTS
  One hundred and twenty-nine teeth were available for follow-up study. By the end of 12 months, the overall success rates were 93.8% in MTA, 91.9% in 3Mixtatin, 62.5% in 3Mix, and 57.1% in simvastatingroups. No statistically significant difference was found between the outcomes of MTA and 3Mixtatin groups (P > 0.05). 3Mixtatin had statistically superior results compared to 3Mix and simvastatin (P < 0.01).
  
  
  CONCLUSIONS
  Radiographic and clinical outcomes in 3Mixtatin group could suggest it as an acceptable alternative in DPC of primary molar teeth.
authors.affiliation: Department of Paediatric Dentistry, Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, East Azerbaijan, Iran.
authors.forename: Naser
authors.initials: N
authors.lastname: Asl Aminabadi
authors.affiliation: Department of Paediatric Dentistry, Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, East Azerbaijan, Iran.
authors.forename: Soheil
authors.initials: S
authors.lastname: Satrab
authors.affiliation: Department of Paediatric Dentistry, Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, East Azerbaijan, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Najafpour
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, East Azerbaijan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Samiei
authors.affiliation: Department of Oral Science, Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, East Azerbaijan, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Jamali
authors.affiliation: Student Research Committee, Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, East Azerbaijan, Iran.|Dental and Periodontal Research Center, Tabriz University of Medical Science, Tabriz, East Azerbaijan, Iran.
authors.forename: Sajjad
authors.initials: S
authors.lastname: Shirazi
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000627:therapeutic use*; D017610:Calcium Compounds / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003785:Dental Pulp Capping; D003788:Dental Pulp Diseases / Q000188:drug therapy; D003789:Dental Pulp Exposure / Q000628:therapy; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007492:Iran; D008297:Male; D008422:Materials Testing; D008795:Metronidazole / Q000627:therapeutic use; D008963:Molar / Q000187:drug effects*; D010087:Oxides / Q000627:therapeutic use*; D010865:Pilot Projects; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D012391:Root Resorption / Q000188:drug therapy; D017640:Silicates / Q000627:therapeutic use*; D019821:Simvastatin / Q000627:therapeutic use; D014094:Tooth, Deciduous / Q000000981:diagnostic imaging / Q000187:drug effects*; D016896:Treatment Outcome; D015035:Zinc Oxide-Eugenol Cement / Q000627:therapeutic use
chemical_list: D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; D012387:Root Canal Filling Materials; D017640:Silicates; D015035:Zinc Oxide-Eugenol Cement; C086631:mineral trioxide aggregate; D008795:Metronidazole; D019821:Simvastatin