title: Comparing prognostic strength of acute corticospinal tract injury measured by a new diffusion tensor imaging based template approach versus common approaches.
abstract: BACKGROUND
  Long-term motor outcome of acute stroke patients with severe motor impairment is difficult to predict. While measure of corticospinal tract (CST) injury based on diffusion tensor imaging (DTI) in subacute stroke patients strongly predicts motor outcome, its predictive value in acute stroke patients is unclear. Using a new DTI-based, density-weighted CST template approach, we demonstrated recently that CST injury measured in acute stroke patients with moderately-severe to severe motor impairment of the upper limb strongly predicts motor outcome of the limb at 6 months.
  
  
  METHODS
  The current study compared the prognostic strength of CST injury measured in 10 acute stroke patients with moderately-severe to severe motor impairment of the upper limb by the new density-weighted CST template approach versus several variants of commonly used DTI-based approaches.
  
  
  RESULTS
  Use of the density-weighted CST template approach yielded measurements of acute CST injury that correlated most strongly, in absolute magnitude, with 6-month upper limb strength (rs=0.93), grip (rs=0.94) and dexterity (rs=0.89) compared to all other 11 approaches. Formal statistical comparison of correlation coefficients revealed that acute CST injury measured by the density-weighted CST template approach correlated significantly more strongly with 6-month upper limb strength, grip and dexterity than 9, 10 and 6 of the 11 alternative measurements, respectively.
  
  
  CONCLUSIONS
  Measurements of CST injury in acute stroke patients with substantial motor impairment by the density-weighted CST template approach may have clinical utility for anticipating healthcare needs and improving clinical trial design.
authors.affiliation: MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Kelsi K
authors.initials: KK
authors.lastname: Hirai
authors.affiliation: MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Benjamin N
authors.initials: BN
authors.lastname: Groisser
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: William A
authors.initials: WA
authors.lastname: Copen
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Aneesh B
authors.initials: AB
authors.lastname: Singhal
authors.affiliation: MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: judith@nmr.mgh.harvard.edu.
authors.forename: Judith D
authors.initials: JD
authors.lastname: Schaechter
mesh_terms: D000208:Acute Disease; D000368:Aged; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009069:Movement Disorders / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis; D011712:Pyramidal Tracts / Q000293:injuries* / Q000473:pathology* / Q000503:physiopathology; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications / Q000175:diagnosis* / Q000473:pathology* / Q000503:physiopathology; D034941:Upper Extremity / Q000503:physiopathology; D055815:Young Adult