title: Induced sputum in young healthy children with cystic fibrosis.
abstract: Young children with CF are often asymptomatic and non-productive, yet CF lung disease occurs early in life. Cough swabs are used routinely to sample bacteria from the CF respiratory tract in non-productive healthy children; bronchoscopy is used to definitively sample the lower airway, but is an invasive procedure. Induced sputum is a non-invasive approach to sampling the lower airway. The article concentrates on how well it is tolerated in children, how successful it is in identifying respiratory pathogens, and how it may be important in routine surveillance if 16S technology is to be used in the clinical forum.
authors.affiliation: Consultant in Paediatric Respiratory Medicine and Honorary Senior Lecturer, The Children's Hospital for Wales, Cardiff, UK. Electronic address: Julian.forton@wales.nhs.uk.
authors.forename: Julian
authors.initials: J
authors.lastname: Forton
mesh_terms: D000328:Adult; D001419:Bacteria / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology*; D006801:Humans; D007223:Infant; D012141:Respiratory Tract Infections / Q000175:diagnosis*; D013183:Sputum / Q000382:microbiology*
keywords: Children; Cystic Fibrosis; Induced sputum; Respiratory microbiome