title: Continuous ultraviolet irradiation increases the adverse effects of photoreactive nanoparticles on the early development of Oryzias latipes.
abstract: The present study investigated the toxicity of photoreactive nanoparticles (NPs) on the development of Oryzias latipes. Buoyant fish embryos are potentially vulnerable to sunlight-derived ultraviolet (UV) irradiation. Zinc oxide (ZnO) NPs in surface water easily absorb UV irradiation from transmitted solar light. In the present study, O. latipes were exposed to ZnO NPs under irradiation with UV or visible light. The ZnO NPs exhibited considerable toxicity toward embryos and sac fry following UV irradiation, and these toxic effects resulted in increased mortality and abnormalities. The UV irradiation induced more serious effects on embryos than did visible light irradiation, and embryonic exposure resulted in irreversible developmental impairment or death of sac fry. The adverse effects of ZnO NPs may result from Zn ions released from photoreactive ZnO NPs. The present study demonstrates photo-dependent developmental impairment of O. latipes embryos as a result of exposure to ZnO NPs. The results demonstrate that the toxicity of photoreactive ZnO NPs could vary under environmentally relevant UV irradiation. These data could serve as a guide for evaluation of the toxicity of photo-activated NPs in natural surface waters and could be useful for the ecological risk assessment of photoreactive NPs.
authors.affiliation: Department of Environmental Health Science, Konkuk University, Seoul, Korea.
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Shin
authors.affiliation: Department of Environmental Health Science, Konkuk University, Seoul, Korea.
authors.forename: Sun-Hwa
authors.initials: SH
authors.lastname: Nam
authors.affiliation: Department of Environmental Health Science, Konkuk University, Seoul, Korea.
authors.forename: Youn-Joo
authors.initials: YJ
authors.lastname: An
mesh_terms: D000818:Animals; D004625:Embryo, Nonmammalian / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D008027:Light / Q000009:adverse effects*; D053758:Nanoparticles / Q000528:radiation effects* / Q000633:toxicity; D009990:Oryzias / Q000196:embryology*; D014466:Ultraviolet Rays / Q000009:adverse effects; D015034:Zinc Oxide / Q000528:radiation effects* / Q000633:toxicity
chemical_list: D015034:Zinc Oxide
keywords: Fish embryo; Nanoecotoxicology; Nanoparticle; Phototoxicity; UV irradiation