title: Organochlorine pesticides in follicular fluid of women undergoing assisted reproductive technologies from central China.
abstract: Female infertility rates have increased by approximately 4% since the 1980s. There is evidence of adverse effects on female fertility in relation to exposure of chemical pollution in recent years. Follicular fluid samples were collected from 127 woman patients (aged 20-35) who underwent assisted reproductive technologies (ART) and had no records indicating occupational exposure to OCPs. Seventeen OCPs were analyzed in this study. The results showed that methoxychlor was dominant, accounted for 13.4% of total OCPs with a mean concentration of 167.9 ± 33.9 ng/g lipid weight (lw), followed by heptachlor-epoxide, hexachlorocyclohexanes, endrin and DDT. The concentrations of OCPs in the follicular fluid samples in the present study were moderate in comparison with those reported from developed or industrialized countries. All these pollutants can accumulate in different tissues of human body through diet, drinking water and respiration. No correlation between patient age and OCP concentrations was observed in this study.
authors.affiliation: Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yindi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI 96822, USA. Electronic address: qingl@hawaii.edu.
authors.forename: Qing X
authors.initials: QX
authors.lastname: Li
authors.affiliation: Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China. Electronic address: wangjun@wbgcas.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D002681:China; D004785:Environmental Pollutants / Q000032:analysis; D005260:Female; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D007246:Infertility; D018811:Maternal Exposure; D010575:Pesticides / Q000032:analysis*; D027724:Reproductive Techniques, Assisted
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides
keywords: Assisted reproductive technologies (ART); Dichlorodiphenyltrichloroethane (DDTs); Hexachlorocyclohexanes (HCHs); Methoxychlor; Organochlorine pesticides (OCPs); Woman follicular fluid