title: Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: A Method for the Synthesis of Ketals and Ketones.
abstract: A novel electrochemical oxidative decarboxylation of disubstituted malonic acids leading to dimethoxy ketals is described. In the presence of NH3, a wide range of disubstituted malonic acids was transformed into the corresponding ketals in good to excellent yields under electrochemical conditions. When the crude reaction mixture, obtained after electrolysis, was directly treated with 1 M aq HCl, the initially generated ketals were smoothly transformed into the corresponding ketones in a single vessel operation.
authors.affiliation: Laboratory of Organic and Medicinal Chemistry, Université Catholique de Louvain , Place Louis Pasteur 1 bte L4.01.02, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Ma
authors.affiliation: Laboratory of Organic and Medicinal Chemistry, Université Catholique de Louvain , Place Louis Pasteur 1 bte L4.01.02, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Xiya
authors.initials: X
authors.lastname: Luo
authors.affiliation: Laboratory of Organic and Medicinal Chemistry, Université Catholique de Louvain , Place Louis Pasteur 1 bte L4.01.02, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Simon
authors.initials: S
authors.lastname: Dochain
authors.affiliation: Laboratory of Organic and Medicinal Chemistry, Université Catholique de Louvain , Place Louis Pasteur 1 bte L4.01.02, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Mathot
authors.affiliation: Laboratory of Organic and Medicinal Chemistry, Université Catholique de Louvain , Place Louis Pasteur 1 bte L4.01.02, 1348 Louvain-la-Neuve, Belgium.
authors.forename: István E
authors.initials: IE
authors.lastname: Markò
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003653:Decarboxylation; D004987:Ethers; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000080:Acetals; D004987:Ethers; D007659:Ketones; D008314:Malonates; C030290:malonic acid