title: [ROLE OF NEUTRAL SPHINGOMYELINASE IN AGE-DEPENDENT MUSCLE INSULIN RESISTANCE DEVELOPMENT AND ITS IMPROVEMENT WITH N-ACETYLCYSTEINE].
abstract: In the present study, we evaluated the role of ceramide in age-dependent and etoposide-induced insulin resistance. A significant increase in the level of ceramide and decrease of gluthatione (GSH) content and tissue sensitivity to insulin has been observed in 24-month-old rats as compared with 3-month-old animals. Etoposide imitates ageing-like changes in muscle tissue of young rats. N-acetylcysteine as well as specific neutral sphingomyelinase (nSMase) inhibitor--GW4869, decreases ceramide content and increases GSH level, and enhances the insulin-induced [3H-D-glucose uptake in the "aged" tissue. These data indicate that nSMase play important role in the age- and drug-induced ceramide-dependent insuline resistance.
authors.forename: N A
authors.initials: NA
authors.lastname: Babenko
authors.forename: O A
authors.initials: OA
authors.lastname: Timofiĭchuk
authors.forename: A N
authors.initials: AN
authors.lastname: Belyĭ
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D002518:Ceramides / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D051381:Rats
chemical_list: D002518:Ceramides; D047908:Intracellular Signaling Peptides and Proteins; C491113:Nsmaf protein, rat; D000111:Acetylcysteine