title: Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia.
authors.affiliation: Children's Hospital of Philadelphia (CHOP), Department of Pediatrics, Division of Hematology, PA.
authors.forename: Carla
authors.initials: C
authors.lastname: Casu
authors.affiliation: Isis Pharmaceuticals, Inc. Carlsbad, CA, USA.
authors.forename: Mariam
authors.initials: M
authors.lastname: Aghajan
authors.affiliation: Children's Hospital of Philadelphia (CHOP), Department of Pediatrics, Division of Hematology, PA.
authors.forename: Paraskevi Rea
authors.initials: PR
authors.lastname: Oikonomidou
authors.affiliation: Isis Pharmaceuticals, Inc. Carlsbad, CA, USA.
authors.forename: Shuling
authors.initials: S
authors.lastname: Guo
authors.affiliation: Isis Pharmaceuticals, Inc. Carlsbad, CA, USA.
authors.forename: Brett P
authors.initials: BP
authors.lastname: Monia
authors.affiliation: Children's Hospital of Philadelphia (CHOP), Department of Pediatrics, Division of Hematology, PA rivellas@email.chop.edu.
authors.forename: Stefano
authors.initials: S
authors.lastname: Rivella
mesh_terms: D000818:Animals; D000077543:Deferiprone; D004195:Disease Models, Animal; D004920:Erythropoiesis / Q000187:drug effects* / Q000235:genetics; D007502:Iron Chelating Agents / Q000494:pharmacology*; D008565:Membrane Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D011728:Pyridones / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism; D017086:beta-Thalassemia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism
chemical_list: D007502:Iron Chelating Agents; D008565:Membrane Proteins; D011728:Pyridones; D000077543:Deferiprone; D012697:Serine Endopeptidases; C467801:matriptase 2
keywords: chelator; erythropoiesis; iron metabolism; iron overload; red blood cells