title: Comparison between Collagenase Injection and Partial Fasciectomy in the Treatment of Dupuytren's Contracture.
abstract: BACKGROUND
  A comparative study between two treatment methods (collagenase injection and open partial fasciectomy) for Dupuytren's contracture. This study will determine differences in clinical outcome, complication rate and patient satisfaction.
  
  
  METHODS
  37 patients with 62 metacarpophalangeal joints (MCP) and 44 proximal interphalangeal joints (PIP) treated. There were 21 MCP joints (34%) and 8 PIP joints (18%) treated with injection. The remaining 66% of MCP joints and 82% of PIP joints were treated by open partial fasciectomy.
  
  
  RESULTS
  Overall, both treatment methods were successful in correcting the passive extension deficit in the MCP and PIP joints. Minor complications were reported in 45% of patients in the injection group versus 42% in the surgery group. Patient satisfaction was nearly equal for both groups.
  
  
  CONCLUSIONS
  Both treatment options have proven their effectiveness in treating Dupuytren's contracture. Open surgery is able to address additional joint contracture problems commonly associated with Dupuytren's disease. Collagenase injection has the advantage of early return of hand function and avoidance of surgical complications.
authors.affiliation: ‡ Department of Orthopaedics, University of Malaya, Malaysia.
authors.forename: Terence Khai Wei
authors.initials: TK
authors.lastname: Tay
authors.affiliation: * C.M. Kleinert Institute for Hand and Microsurgery, Louisville, KY, USA.
authors.forename: Huey
authors.initials: H
authors.lastname: Tien
authors.affiliation: † Department of Otolaryngology, University of Malaya, Malaysia.
authors.forename: Elizabeth Yenn Lynn
authors.initials: EY
authors.lastname: Lim
mesh_terms: D000368:Aged; D017364:Collagenases / Q000627:therapeutic use*; D004387:Dupuytren Contracture / Q000188:drug therapy* / Q000601:surgery*; D000071938:Fasciotomy; D005260:Female; D005384:Finger Joint; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008662:Metacarpophalangeal Joint; D008875:Middle Aged; D019637:Orthopedic Procedures; D017060:Patient Satisfaction; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D017364:Collagenases
keywords: Collagenase; Dupuytren’s disease; Joint contracture; Open partial fasciectomy