title: Intra-Articular Transplantation of Allogeneic BMMSCs Rehabilitates Cartilage Injury of Antigen-Induced Arthritis.
abstract: Apart from the immunosuppressive property, which has been widely investigated in the treatment of various autoimmune diseases, bone marrow mesenchymal stem cells (BMMSCs) also exhibit the chondrogenic capacity. Recently, BMMSCs have attracted more and more attention in the remission of rheumatoid arthritis (RA) and the reconstruction of cartilage injury. In addition to the significant regulatory hurdles of systemic treatment by BMMSCs, the poor inhibitory efficiency on articular inflammatory reaction and the inferior result of preventing the persistent destruction of cartilage were observed. Herein, toward the ovalbumin (OVA)-induced arthritis in rabbits, the in situ transplantation of fibrin gel-encapsulated BMMSCs to osteochondral defect was confirmed to result in the decreased levels of cytokines, such as interleukin-1β, interleukin-6, tumor necrosis factor-α, and anti-OVA antibody, in the serum. What is more, the implantation of BMMSCs also inhibited the proliferation of antigen-specific lymphocytes. Meanwhile, the fibrin gel-encapsulated BMMSCs performed outstanding capacity of cartilage repair, resulted in the remission of local joint inflammatory condition, and prevented further articular cartilage damage. The results demonstrated that the transplantation of BMMSCs in fibrin gel to osteochondral defect under arthritic condition could effectively stimulate BMMSCs to exhibit the immunosuppression and cartilage protection capability, as well as cartilage repair. This study provided a new therapeutic strategy for RA-induced cartilage injury through the local transplantation of BMMSCs.
authors.affiliation: 1 Department of Orthopedics, The Second Hospital of Jilin University , Changchun, People's Republic of China .
authors.forename: He
authors.initials: H
authors.lastname: Liu
authors.affiliation: 2 Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry , Chinese Academy of Sciences, Changchun, People's Republic of China .
authors.forename: Jianxun
authors.initials: J
authors.lastname: Ding
authors.affiliation: 3 Hallym University , Chuncheon, Gangwon-do, Korea.
authors.forename: Chenyu
authors.initials: C
authors.lastname: Wang
authors.affiliation: 1 Department of Orthopedics, The Second Hospital of Jilin University , Changchun, People's Republic of China .
authors.forename: Jincheng
authors.initials: J
authors.lastname: Wang
authors.affiliation: 4 Academy of Translational Medicine, The First Bethune Hospital of Jilin University , Changchun, People's Republic of China .
authors.forename: Yinan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 1 Department of Orthopedics, The Second Hospital of Jilin University , Changchun, People's Republic of China .
authors.forename: Modi
authors.initials: M
authors.lastname: Yang
authors.affiliation: 1 Department of Orthopedics, The Second Hospital of Jilin University , Changchun, People's Republic of China .
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Jia
authors.affiliation: 1 Department of Orthopedics, The Second Hospital of Jilin University , Changchun, People's Republic of China .
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1 Department of Orthopedics, The Second Hospital of Jilin University , Changchun, People's Republic of China .|5 Hand & Foot Surgery and Reparative & Reconstruction Surgery Center, The Second Hospital of Jilin University , Changchun, People's Republic of China .
authors.forename: Fei
authors.initials: F
authors.lastname: Chang
authors.affiliation: 1 Department of Orthopedics, The Second Hospital of Jilin University , Changchun, People's Republic of China .|5 Hand & Foot Surgery and Reparative & Reconstruction Surgery Center, The Second Hospital of Jilin University , Changchun, People's Republic of China .
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: 2 Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry , Chinese Academy of Sciences, Changchun, People's Republic of China .
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000941:Antigens; D001168:Arthritis / Q000276:immunology* / Q000628:therapy*; D001172:Arthritis, Rheumatoid / Q000139:chemically induced / Q000276:immunology* / Q000628:therapy*; D001854:Bone Marrow Cells / Q000276:immunology; D002358:Cartilage, Articular / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D002478:Cells, Cultured; D020219:Chondrogenesis / Q000276:immunology; D007269:Injections, Intra-Arterial; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D011817:Rabbits; D016896:Treatment Outcome
chemical_list: D000941:Antigens