title: Long-term effects of tolvaptan in patients requiring recurrent hospitalization for heart failure.
abstract: Although reports suggest that tolvaptan does not reduce survival or subsequent hospitalization rates in heart failure patients, its continuous use has shown good outcomes in some patients who cannot be effectively managed with high doses of loop diuretics. Therefore, we investigated the association of patient characteristics and continued tolvaptan use in heart failure patients with changes in the frequency and annual duration of patient hospitalization due to heart failure. We carefully reviewed the medical records of patients hospitalized due to heart failure who began tolvaptan therapy and continued with outpatient treatment between December 2010 and November 2013 (tolvaptan group); patients hospitalized for heart failure between May 2008 and March 2009 served as controls. We set the reference dates as the start of tolvaptan therapy (tolvaptan group) or as the date of admission (control group). The changes in hospitalization frequency and total hospitalization time due to heart failure, before and after the reference dates, were not significantly different between the tolvaptan and control groups. In the tolvaptan group, a high estimated glomerular filtration rate was a predictor of decreased hospitalization. Continuous tolvaptan use did not decrease hospitalization duration in all heart failure patients, but good renal function was predictive of a good response.
authors.affiliation: Department of Cardiovascular Medicine, Tosei General Hospital, Seto, Japan ; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Ogawa
authors.affiliation: Department of Cardiovascular Medicine, Tosei General Hospital, Seto, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ajioka
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishii
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Okumura
authors.affiliation: Department of Cardiovascular Medicine, Tosei General Hospital, Seto, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Murase
authors.affiliation: Department of Cardiovascular Medicine, Tosei General Hospital, Seto, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osanai
authors.affiliation: Department of Cardiovascular Medicine, Tosei General Hospital, Seto, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Nakasima
authors.affiliation: Department of Cardiovascular Medicine, Tosei General Hospital, Seto, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Asano
authors.affiliation: Department of Cardiovascular Medicine, Tosei General Hospital, Seto, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Department of Cardiovascular Medicine, Tosei General Hospital, Seto, Japan.
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
keywords: heart failure; hospitalization; tolvaptan