title: Catalytic Asymmetric Formal Insertion of Aryldiazoalkanes into the C-H Bond of Aldehydes: Synthesis of Enantioenriched Acyclic α-Tertiary Aryl Ketones.
abstract: A novel, catalytic enantioselective route to synthesize a variety of α-tertiary aryl ketones via a boron Lewis acid promoted formal insertion of aryldiazoalkane into the C-H bond of both aromatic and aliphatic aldehydes is described. In the presence of chiral (S)-oxazaborolidinium ion catalyst 1, the reaction proceeded in good yields (up to 94%) with excellent enantioselectivities (up to 99% ee).
authors.affiliation: Department of Chemistry, Sungkyunkwan University , Suwon, 440-746, Korea.
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Kang
authors.affiliation: Department of Chemistry, Sungkyunkwan University , Suwon, 440-746, Korea.
authors.forename: Dong Guk
authors.initials: DG
authors.lastname: Nam
authors.affiliation: Western Seoul Center, Korea Basic Science Institute , Seoul 120-140, Korea.
authors.forename: Geum-Sook
authors.initials: GS
authors.lastname: Hwang
authors.affiliation: Department of Chemistry, Sungkyunkwan University , Suwon, 440-746, Korea.
authors.forename: Do Hyun
authors.initials: DH
authors.lastname: Ryu