title: Suicidal risk from TADS study was higher than it first appeared.
abstract: Completed suicides are a major cause of death in adolescents in Sweden. Forensic analysis of completed suicides in children and adolescents shows there is one completed suicide per 1000 children taking a selective serotonin re-uptake inhibitor (SSRI). In order to elucidate these events we undertook a study of the results and reporting of suicidal events in the Treatment of Adolescents with Depression Study (TADS). We conclude that a major, albeit underreported, finding in the TADS was the significant increase of suicidal events in the adolescents on antidepressant medication in comparison to the group on placebo medication. The proportions of suicidal events were 11% and 2.7% respectively. This increased risk of suicidal events might be related to the high incidence of medication with an SSRI in the group of completed suicides among Swedish adolescents.
authors.affiliation: Department of Women's and Children's Health, Child and Adolescent Psychiatric Unit, Karolinska Institutet, Astrid Lindgren Children's Hospital, Stockholm, Sweden.|Stockholm Child and Adolescent Psychiatry, BUP Huddinge, Stockholm, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Högberg
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Nevada School of Medicine, Reno, NV, USA.
authors.forename: David O
authors.initials: DO
authors.lastname: Antonuccio
authors.affiliation: Bangor University, Wales, UK.
authors.forename: David
authors.initials: D
authors.lastname: Healy
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D059020:Suicidal Ideation; D013405:Suicide / Q000706:statistics & numerical data*; D013548:Sweden / Q000453:epidemiology
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors
keywords: CBT; SSRIs; TADS; adolescent depression; suicide