title: Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.
abstract: Dysregulation of protein arginine methyltransferase 1 (PRMT1) has been reported in several cancer types. However, its expression pattern and biological functions in esophageal squamous cell carcinoma (ESCC) remained unknown. Here, we have found that the expression of PRMT1 was up-regulated in ESCC samples. In the biological function studies, forced expression of PRMT1 promoted the growth and migration of ESCC cells. However, knocking down the expression of PRMT1 inhibited the growth, migration, and metastasis of ESCC cells. Moreover, PRMT1 activated Hedgehog signaling and up-regulated the expression of target genes downstream of Hedgehog signaling. Taken together, our study revealed the oncogenic roles of PRMT1 in the progression of ESCC, and PRMT1 might be a promising therapeutic target for the treatment of ESCC.
authors.affiliation: Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, 168 of Changhai Road, Shanghai, 200433, China.
authors.forename: Weizheng
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Thoracic Surgery, The Second People's Hospital of Hefei, Anhui Province, Hefei, 230011, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yue
authors.affiliation: Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, 168 of Changhai Road, Shanghai, 200433, China.
authors.forename: Chunguang
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, 168 of Changhai Road, Shanghai, 200433, China.
authors.forename: Hezhong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, 168 of Changhai Road, Shanghai, 200433, China. yuanyang20150614@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics / Q000473:pathology*; D000077277:Esophageal Squamous Cell Carcinoma; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D053823:Hedgehog Proteins / Q000235:genetics; D006801:Humans; D011484:Protein-Arginine N-Methyltransferases / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
chemical_list: D053823:Hedgehog Proteins; D012097:Repressor Proteins; C099988:PRMT1 protein, human; D011484:Protein-Arginine N-Methyltransferases
keywords: Cell growth and migration; ESCC; Hedgehog signaling; PRMT1