title: Psychiatric disorders and suicidal behavior in neurotypical young adults with childhood-onset epilepsy.
abstract: OBJECTIVE
  We examined the associations of lifetime and current histories of psychiatric disorders and of suicidal thoughts and behaviors with childhood-onset epilepsies in a community-based cohort of young adults.
  
  
  METHODS
  Cases were neurotypical (normal neurologic, cognitive, and imaging examinations and no evidence of a brain insult responsible for the epilepsy) young adults with childhood-onset epilepsy followed since the onset of their epilepsy approximately 15 years earlier and recruited as part of a community-based study. They were compared to two different control groups: siblings and external controls from the National Comorbidity Survey-Replication (NCS-R). The Diagnostic Interview Survey assessed lifetime and current Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) diagnoses of mood disorders and anxiety disorders. Suicidal thoughts and suicide attempt were assessed using the Diagnostic Interview Survey for Children-IV and the Diagnostic Interview Survey (DIS-IV).
  
  
  RESULTS
  Two hundred fifty-seven cases and 134 sibling controls participated in the DIS-IV portion of the young adult assessment. Comparing cases both to their sibling controls and to the controls drawn from the NCS-R, we did not find any evidence to suggest a higher prevalence of lifetime and current mood or anxiety disorders, suicidal thoughts, and suicide attempt in young adults with childhood-onset epilepsies.
  
  
  CONCLUSIONS
  Our findings from a community-based sample of neurotypical young adults do not suggest a substantial or lasting association between childhood epilepsy and psychiatric disorders and suicidal behavior.
authors.affiliation: GH Sergievsky Center and Department of Epidemiology, Columbia University, New York, New York, U.S.A.
authors.forename: Elisa
authors.initials: E
authors.lastname: Baldin
authors.affiliation: GH Sergievsky Center and Department of Epidemiology, Columbia University, New York, New York, U.S.A.
authors.forename: Dale C
authors.initials: DC
authors.lastname: Hesdorffer
authors.affiliation: David Geffen School of Medicine, Semel Institute of Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California, U.S.A.
authors.forename: Rochelle
authors.initials: R
authors.lastname: Caplan
authors.affiliation: Department of Pediatrics, Epilepsy Center, Ann & Robert H Lurie Children's Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, U.S.A.
authors.forename: Anne T
authors.initials: AT
authors.lastname: Berg
mesh_terms: D000328:Adult; D017668:Age of Onset; D003072:Cognition Disorders / Q000209:etiology*; D015331:Cohort Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004827:Epilepsy / Q000150:complications* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009422:Nervous System Diseases / Q000209:etiology*; D009460:Neurologic Examination; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000209:etiology*; D012111:Residence Characteristics; D018709:Statistics, Nonparametric; D013406:Suicide, Attempted / Q000523:psychology*; D055815:Young Adult
keywords: Case-control study; Epilepsy; Psychiatric disorders