title: Prevention, diagnosis and treatment of cervical cancer precursor lesions at the Xingu Indigenous Park, Brazil.
abstract: OBJECTIVE
  To describe the prevention, diagnosis, and treatment of cervical cancer precursor lesions at the Xingu Indigenous Park (PIX) from 2005 to 2006.
  
  
  METHODS
  Observational, transversal study. The research sample consisted of 503 sexually active women aged 12 years and older. The research was performed in three stages: screening, colposcopy, and surgical treatment by large loop excision of the transformation zone.
  
  
  RESULTS
  The cytopathological screening coverage was of 99.6%. The rate of cytologic atypia was 11.7%. Together, low-grade squamous intraepithelial lesions (LSILs) and high-grade squamous intraepithelial lesions (HSILs) were observed in 4.6% of the women. The cytological examination returned a sensitivity of 54%, specificity of 97%, a positive predictive value of 88%, and a negative predictive value of 83%. In the anatomopathological examinations of biopsies, the rate of HSILs was 30.2%. The sensitivity of the anatomopathological examination of biopsies was 72.2%, the specificity was 100%, the positive predictive value was 100%, and the negative predictive value was 44.4%.
  
  
  CONCLUSIONS
  Viable strategies for preventing, diagnosing, and treating cervical cancer precursor lesions in women from the PIX include increasing annual coverage of cytopathological examinations, early detection of cervical intraepithelial lesions, and treatment and follow-up of detected cases.
authors.forename: E Ribeiro
authors.initials: ER
authors.lastname: Pereira
authors.forename: N M de Gois
authors.initials: NM
authors.lastname: Speck
authors.forename: D A
authors.initials: DA
authors.lastname: Rodrigues
authors.forename: V Grisolia
authors.initials: VG
authors.lastname: De Freitas
authors.forename: J C Lascasas
authors.initials: JC
authors.lastname: Ribalta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000473:pathology*; D002648:Child; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis / Q000517:prevention & control* / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000517:prevention & control* / Q000628:therapy; D014626:Vaginal Smears