title: Reciprocal interaction of diet and microbiome in inflammatory bowel diseases.
abstract: OBJECTIVE
  Diet is an emerging but poorly defined disease modulator in inflammatory bowel diseases (IBDs). Dietary factors exert direct effects on epithelial and immune cells and indirectly modulate immune homeostasis by shaping the intestinal microbiota.
  
  
  RESULTS
  The increase in IBD prevalence in industrialized countries is associated with lifestyle changes including diets rich in energy, saturated fats, meat and sugar. Despite the fact that the intestinal ecosystem shows high stability and resilience to short-term perturbations, long-term dietary habits have profound effects on composition and function eventually leading to dysbiosis, that is changes in microbial composition associated with deleterious effects to the host. High-throughput sequencing data generated deeper insights of the intestinal ecosystems related to health and disease. However, the available cohort-studies establish associative relationships between microbiota changes and disease, rather than causality. New mouse models of intestinal inflammation and the possibility to transfer disease-associated microbial consortia state an essential tool to unravel the potential of diet-induced microbial shifts.
  
  
  CONCLUSIONS
  This review will discuss new insights of how nutrition or single dietary factors shape the intestinal ecosystem. Furthermore, we want to provide perspectives for clinical translation of this knowledge to treat or prevent IBD.
authors.affiliation: Technische Universität München, Chair of Nutrition and Immunology, Freising-Weihenstephan, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Schaubeck
authors.forename: Dirk
authors.initials: D
authors.lastname: Haller
mesh_terms: D000818:Animals; D004032:Diet / Q000009:adverse effects; D064806:Dysbiosis / Q000276:immunology / Q000382:microbiology; D000069196:Gastrointestinal Microbiome / Q000276:immunology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000178:diet therapy / Q000276:immunology* / Q000382:microbiology*; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D009747:Nutritional Physiological Phenomena / Q000276:immunology