title: Diagnostic Accuracy of Tumor Markers CYFRA21-1 and CA125 in the Differential Diagnosis of Ascites.
abstract: BACKGROUND
  The usefulness of tumor markers in the differential diagnosis of cancer in patients with ascites remains a matter of controversy. Few studies have reported the measurement of cancer antigen 125 (CA125) and cytokeratin 19 soluble fragments (CYFRA21-1) in ascitic fluid. The aim of the present study was to evaluate the diagnostic accuracy of these tumor markers in the detection of malignant ascites.
  
  
  METHODS
  We analyzed CA125 and CYFRA21-1 from 143 consecutive undiagnosed patients with ascitis.
  
  
  RESULTS
  Use of CA125 gave a sensitivity of 39.7% and a specificity of 98.8%, and CYFRA21-1 a sensitivity of 50.0% and a specificity of 97.6% in differential diagnosis of malignant ascites. For combined use of CA125 plus CYFRA21-1, sensitivity was 65.5% and specificity 96.5%. In patients with negative cytology, these two tumor markers had a sensitivity of 50% and a specificity of 96.5%.
  
  
  CONCLUSIONS
  The determination of tumor markers in ascitic fluid could be useful for the diagnostic assessment of patients with ascites.
authors.affiliation: Department of Laboratory Medicine, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain jtrape@althaia.cat.
authors.forename: Jaume
authors.initials: J
authors.lastname: Trapé
authors.affiliation: Polytechnic School University of Vic-Central University of Catalonia, Vic, Catalonia, Spain.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Gurt
authors.affiliation: Department of Laboratory Medicine, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Josefina
authors.initials: J
authors.lastname: Franquesa
authors.affiliation: Department of Medical Oncology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain Clinical Research Unit, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Montesinos
authors.affiliation: Clinical Research Unit, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Arnau
authors.affiliation: Department of Laboratory Medicine, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Sala
authors.affiliation: Department of Pathology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Sant
authors.affiliation: Department of Medical Oncology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Casado
authors.affiliation: Department of Internal Medicine, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Ordeig
authors.affiliation: Department of Gynecology and Obstetrics, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Bergos
authors.affiliation: Department of Gastroenterology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Vida
authors.affiliation: Department of Gastroenterology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Pau
authors.initials: P
authors.lastname: Sort
authors.affiliation: Department of Gastroenterology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Isava
authors.affiliation: Department of Laboratory Medicine, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: González
authors.affiliation: Clinical Chemistry Hospital Clinic Barcelona, Barcelona, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Molina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000378:metabolism*; D001201:Ascites / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018394:CA-125 Antigen / Q000378:metabolism*; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053539:Keratin-19 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000150:complications* / Q000473:pathology; D016066:Pleural Effusion, Malignant / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D011379:Prognosis; D012372:ROC Curve
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; C102012:antigen CYFRA21.1
keywords: Ascitic fluid; CA125; CYFRA 21-1; differential diagnosis; malignant effusion