title: Statin Use is Associated with Better Cognitive Function in Elderly with Type 2 Diabetes.
abstract: The pleiotropic contribution of statins on cognition is uncertain. From 840 patients in the cohort from the Israel Diabetes and Cognitive Decline Study, we identified 61 non-statin users and compared them with 45 patients who had used statins at least 90% of the time. Analysis of covariance was performed to compare mean cognitive z-scores between statin users and non-users while adjusting for socio-demographic, diabetes-related, and cardiovascular covariates which included change in cholesterol by year. Overall cognition, memory, and executive function was found to be significantly better in statin users (p <  0.0008). This suggests a positive effect of statins on cognitive function of type 2 diabetes patients that is independent of cholesterol levels.
authors.affiliation: Maccabi Healthcare Services, Tel Aviv, Israel.|The Department of Family Medicine, The Sackler Faculty of Medicine. University of Tel Aviv, Tel Aviv, Israel.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Heymann
authors.affiliation: Memory clinic, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
authors.forename: Ramit
authors.initials: R
authors.lastname: Ravona-Springer
authors.affiliation: Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: Erin L
authors.initials: EL
authors.lastname: Moshier
authors.affiliation: Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: James
authors.initials: J
authors.lastname: Godbold
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.|The Josef Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
authors.forename: Michal Schnaider
authors.initials: MS
authors.lastname: Beeri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D009483:Neuropsychological Tests; D012111:Residence Characteristics
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: All cognitive disorders/dementia; Alzheimer’s disease; case control studies; diabetes