title: MicroRNA in prostate cancer.
abstract: In the United States of America male prostate cancer (PCa) is the most dominant malignancy and the second highest cause of cancer-related mortality risk compared to lung and colon cancers. MicroRNAs (miRNAs) are a class of endogenously expressed small, non-coding, single-stranded RNA which function as regulators of gene expression. They influence various physiological and pathophysiological processes. In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed.
authors.affiliation: Molecular Biology Unit, Entomology Research Institute, Loyola College, Nungambakkam, Chennai 600 034, India.
authors.forename: Kasomva
authors.initials: K
authors.lastname: Khanmi
authors.affiliation: Molecular Biology Unit, Entomology Research Institute, Loyola College, Nungambakkam, Chennai 600 034, India; Visiting Professor Programme, Deanship of Scientific Research, College of Science, King Saud University, Saudi Arabia. Electronic address: eriloyola@hotmail.com.
authors.forename: Savarimuthu
authors.initials: S
authors.lastname: Ignacimuthu
authors.affiliation: Molecular Biology Unit, Entomology Research Institute, Loyola College, Nungambakkam, Chennai 600 034, India.
authors.forename: Michael Gabriel
authors.initials: MG
authors.lastname: Paulraj
mesh_terms: D002453:Cell Cycle; D049109:Cell Proliferation; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D011944:Receptors, Androgen / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D011944:Receptors, Androgen
keywords: Androgen; MicroRNA (miRNA); Post-transcription; Prostate cancer