title: Accuracy of plasma interleukin-18 and adiponectin concentrations in predicting metabolic syndrome and cardiometabolic disease risk in middle-age Brazilian men.
abstract: The aims of this cross-sectional study were to explore the ability of serum interleukin 18 (IL-18) and adiponectin to identify metabolic syndrome (MetS), and to verify their association with an index of central lipid overaccumulation (lipid accumulation product (LAP)) and cardiometabolic risk factors in a population of middle-aged Brazilian men. A group of 218 apparently healthy middle-aged Brazilian men (age, 50.3 ± 4.97 years) underwent anthropometric, clinical, sociodemographic, and standard serum biochemical assessments. LAP was calculated and the study participants were categorized into 3 groups according to serum IL-18 and adiponectin cut-points tertiles to verify the association of these biomarkers with cardiometabolic risk factors. The MetS group had more less active (p = 0.03) and obese (p < 0.01) individuals who exhibited higher IL-18 (p < 0.01) and lower adiponectin (p < 0.01) than did those in the group with no MetS. After adjustments (age, smoking, alcohol consumption, physical activity level, and total body fat), serum IL-18 ≥ 336.4 pg/mL was an independent factor for MetS occurrence and it was directly associated with LAP (≥51.28), central obesity, hypertriglyceridemia, and hypertension (p < 0.05), but not with high-density lipoprotein cholesterol (HDL-C). Serum adiponectin ≥ 7.02 μg/mL was negatively associated with MetS occurrence, LAP, hypertriglyceridemia, and low HDL-C (p < 0.05), but not with central obesity and hypertension. In conclusion, both IL-18 and adiponectin demonstrated the ability to identify MetS in this population, with IL-18 being more accurate. The association of these biomamarkers with LAP and cardiometabolic risk factors highlights its relevance as a diagnostic tool.
authors.affiliation: a Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.|b Department of Physical Education Science and Health, Universidade Federal de São João del-Rei, São João del-Rei, Minas Gerais, Brazil.
authors.forename: Alessandro
authors.initials: A
authors.lastname: de Oliveira
authors.affiliation: a Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
authors.forename: Helen Hermana
authors.initials: HH
authors.lastname: Hermsdorff
authors.affiliation: a Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
authors.forename: Paula G
authors.initials: PG
authors.lastname: Cocate
authors.affiliation: c Department of General Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
authors.forename: Eliziaria C
authors.initials: EC
authors.lastname: Santos
authors.affiliation: a Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
authors.forename: Josefina
authors.initials: J
authors.lastname: Bressan
authors.affiliation: d Department of Physical Education, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
authors.forename: Antônio José
authors.initials: AJ
authors.lastname: Natali
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001938:Brazil; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis*; D008875:Middle Aged; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020382:Interleukin-18
keywords: adipokines; adiponectine; cardiometabolic risk; interleukine; interleukins; metabolic syndrome; risque cardiométabolique; syndrome métabolique