title: Synthesis of Novel 4'-Trifluoromethyl-5'-Norcarbocyclic C-Nucleoside Phosphonic Acids as Potent Anti-Leukemic Agents.
abstract: The syntheses of novel C-nucleoside phosphonic acids as potential antiviral agents are described. The sugar moiety that served as the nucleoside skeleton was produced starting from commercially available 1,3-dihydroxy cyclopentane. The key C-C bond formation from sugar to base precursor was performed using the Knoevenagel-type condensation. The synthesized compounds exhibited anti-HIV activity and cytotoxicity. Also, the synthesized compounds were screened in vitro for tumor growth inhibitory activity against mouse leukemia cell lines (L-1210, P-815).
authors.affiliation: a BK21-Project Team, College of Pharmacy, Chosun University , Kwangju , South Korea.
authors.forename: Seyeon
authors.initials: S
authors.lastname: Kim
authors.affiliation: a BK21-Project Team, College of Pharmacy, Chosun University , Kwangju , South Korea.
authors.forename: Joon Hee
authors.initials: JH
authors.lastname: Hong
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D045744:Cell Line, Tumor; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D015394:Molecular Structure; D009705:Nucleosides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D010757:Phosphorous Acids / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D003517:Cyclopentanes; D009705:Nucleosides; D010757:Phosphorous Acids
keywords: Antiviral agent; C-nucleoside; Knoevenagel reaction; anti-leukemic agent