title: Neonatal Tetanus in Vietnam: Comprehensive Intensive Care Support Improves Mortality.
abstract: We report a 66% reduction in neonatal tetanus mortality after introducing a new management bundle integrating antibiotic therapy, muscle relaxation and invasive monitoring. The latter allowed rapid detection of autonomic instability which was treated with magnesium sulphate. This is the first report of its use in neonatal tetanus.
authors.affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
authors.forename: Huynh T
authors.initials: HT
authors.lastname: Trieu
authors.affiliation: University of North Sumatera, Jl. Dr. Mansur No. 5, Medan, Indonesia.
authors.forename: Inke N
authors.initials: IN
authors.lastname: Lubis
authors.affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
authors.forename: Phan T
authors.initials: PT
authors.lastname: Qui
authors.affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
authors.forename: Lam M
authors.initials: LM
authors.lastname: Yen
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, UK.
authors.forename: Bridget
authors.initials: B
authors.lastname: Wills
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, UK.
authors.forename: C Louise
authors.initials: CL
authors.lastname: Thwaites
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, UK.
authors.forename: Saraswathy
authors.initials: S
authors.lastname: Sabanathan
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001795:Blood Pressure Determination; D003422:Critical Care / Q000379:methods*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007231:Infant, Newborn; D008278:Magnesium Sulfate / Q000627:therapeutic use; D008991:Monitoring, Physiologic / Q000379:methods; D009465:Neuromuscular Agents / Q000627:therapeutic use; D011175:Positive-Pressure Respiration; D012189:Retrospective Studies; D013742:Tetanus / Q000188:drug therapy / Q000401:mortality* / Q000628:therapy*; D014744:Vietnam / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D006993:Hypnotics and Sedatives; D009465:Neuromuscular Agents; D008278:Magnesium Sulfate
keywords: autonomic dysfunction; magnesium sulfate; neonatal tetanus