title: The prognostic role of Leucine-rich repeat-containing G-protein-coupled receptor 5 in gastric cancer: A systematic review with meta-analysis.
abstract: OBJECTIVE
  The prognostic value of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) in gastric cancer remains controversial. To further investigate this relationship, we performed meta-analyses to systematically review the association between LGR5 expression and various clinical parameters in gastric cancer patients.
  
  
  METHODS
  Eligible studies from PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), Wangfang (Database of Chinese Ministry of Science & Technology) and CBM (China Biological Medicine) databases were evaluated to investigate the association of LGR5 expression with overall survival (OS) and clinicopathological features of gastric cancer.
  
  
  RESULTS
  LGR5 overexpression was significantly associated with poor OS in patients with gastric cancer (HR 1.66, 95% CI 1.02-2.69). LGR5 overexpression was also significantly associated with TNM stage (TIII/TIV vs TI/TII: OR 5.42, 95% CI 1.02-28.72) and lymph node metastasis (positive vs negative: OR 2.30, 95% CI 1.06-5.0).
  
  
  CONCLUSIONS
  Our meta-analysis indicates that LGR5 may be a predictive factor for invasion and metastasis, and poor prognosis in patients with gastric cancer.
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, 28, Jianshe Road, 450052 Zhengzhou, China; Anyang cancer hospital, 455000 Anyang, China.
authors.forename: Tianchen
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, 28, Jianshe Road, 450052 Zhengzhou, China. Electronic address: qiuxguang@163.com.
authors.forename: Xinguang
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Anyang cancer hospital, 455000 Anyang, China.
authors.forename: Jianan
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Anyang cancer hospital, 455000 Anyang, China.
authors.forename: Qingbing
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Anyang cancer hospital, 455000 Anyang, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Anyang cancer hospital, 455000 Anyang, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Anyang cancer hospital, 455000 Anyang, China.
authors.forename: Dongxiao
authors.initials: D
authors.lastname: Bai
mesh_terms: D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011379:Prognosis; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate
chemical_list: C116884:LGR5 protein, human; D043562:Receptors, G-Protein-Coupled