title: Urinary Hypoxanthine as a Measure of Increased ATP Utilization in Late Preterm Infants.
abstract: OBJECTIVE
  To examine the effect of neonatal morbidity on ATP breakdown in late preterm infants.
  
  
  METHODS
  Urinary hypoxanthine concentration, a marker of ATP breakdown, was measured from 82 late preterm infants on days of life (DOL) 3 to 6 using high-performance liquid chromatography. Infants were grouped according to the following diagnoses: poor nippling alone (n = 8), poor nippling plus hyperbilirubinemia (n = 21), poor nippling plus early respiratory disease (n = 26), and respiratory disease alone (n = 27).
  
  
  RESULTS
  Neonates with respiratory disease alone had significantly higher urinary hypoxanthine over DOL 3 to 6 when compared with neonates with poor nippling (P= .020), poor nippling plus hyperbilirubinemia (P< .001), and poor nippling plus early respiratory disease (P= .017). Neonates with poor nippling who received respiratory support for 2 to 3 days had significantly higher hypoxanthine compared with infants who received respiratory support for 1 day (P= .017) or no days (P= .007).
  
  
  CONCLUSIONS
  These findings suggest that respiratory disorders significantly increase ATP degradation in late premature infants.
authors.affiliation: Departments of Basic Sciences (MSH, LS, YA, DSB, DA) and Pediatrics (AH), Loma Linda University School of Medicine; Department of Earth and Biological Sciences, Loma Linda University School of Public Health (IE), Loma Linda, California.
authors.forename: Megan S
authors.initials: MS
authors.lastname: Holden
authors.affiliation: Departments of Basic Sciences (MSH, LS, YA, DSB, DA) and Pediatrics (AH), Loma Linda University School of Medicine; Department of Earth and Biological Sciences, Loma Linda University School of Public Health (IE), Loma Linda, California.
authors.forename: Andrew
authors.initials: A
authors.lastname: Hopper
authors.affiliation: Departments of Basic Sciences (MSH, LS, YA, DSB, DA) and Pediatrics (AH), Loma Linda University School of Medicine; Department of Earth and Biological Sciences, Loma Linda University School of Public Health (IE), Loma Linda, California.
authors.forename: Laurel
authors.initials: L
authors.lastname: Slater
authors.affiliation: Departments of Basic Sciences (MSH, LS, YA, DSB, DA) and Pediatrics (AH), Loma Linda University School of Medicine; Department of Earth and Biological Sciences, Loma Linda University School of Public Health (IE), Loma Linda, California.
authors.forename: Yayesh
authors.initials: Y
authors.lastname: Asmerom
authors.affiliation: Departments of Basic Sciences (MSH, LS, YA, DSB, DA) and Pediatrics (AH), Loma Linda University School of Medicine; Department of Earth and Biological Sciences, Loma Linda University School of Public Health (IE), Loma Linda, California.
authors.forename: Ijeoma
authors.initials: I
authors.lastname: Esiaba
authors.affiliation: Departments of Basic Sciences (MSH, LS, YA, DSB, DA) and Pediatrics (AH), Loma Linda University School of Medicine; Department of Earth and Biological Sciences, Loma Linda University School of Public Health (IE), Loma Linda, California.
authors.forename: Danilo S
authors.initials: DS
authors.lastname: Boskovic
authors.affiliation: Departments of Basic Sciences (MSH, LS, YA, DSB, DA) and Pediatrics (AH), Loma Linda University School of Medicine; Department of Earth and Biological Sciences, Loma Linda University School of Public Health (IE), Loma Linda, California.
authors.forename: Danilyn M
authors.initials: DM
authors.lastname: Angeles
keywords: ATP; high-performance liquid chromatography; hypoxanthine; late preterm; urine