title: HLA Associations in a Cohort of Children With Juvenile Idiopathic Arthritis With and Without Uveitis.
abstract: OBJECTIVE
  Juvenile idiopathic arthritis (JIA)-associated uveitis can lead to ocular complications and vision loss. Alleles HLA-DRB1*08, *11, and *13 are risk alleles for JIA, whereas HLA-DRB1*11 and *13 alleles increase uveitis susceptibility. We examined the association of common HLA-DRB1 alleles in children with JIA alone and JIA-associated uveitis.
  
  
  METHODS
  High-resolution HLA-DRB1 genotyping was performed in 107 children with oligoarticular and polyarticular rheumatoid factor (RF) negative JIA and 373 non-Hispanic white controls. Children with JIA alone and JIA-associated uveitis were of similar race, ethnicity, sex, and age at arthritis diagnosis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  There were 47 children with JIA-associated uveitis and 60 with JIA alone. Compared to controls, only children with JIA-associated uveitis had increased odds of carriage of HLA-DRB1*11 (OR, 2.2 95% [CI, 1.1-4.3], P = 0.023). There also was increased carriage of HLA-DRB1*08 and *13 (OR, 12.6 [95% CI, 2.0-77.8], P = 0.011). Compared to controls and children with JIA alone, those with JIA-associated uveitis had increased odds of carriage of HLA-DRB1*11 and *13 (OR, 9 [95% CI, 2.8-29.0], P < 0.0001 and OR, 8.6 [95% CI, 1.0-74.4], P = 0.042), respectively.
  
  
  CONCLUSIONS
  We report the novel finding that carriage of HLA-DRB1*11 and *13 appears to increase the risk of uveitis in children with JIA.
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States.
authors.forename: Sheila T
authors.initials: ST
authors.lastname: Angeles-Han
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States.
authors.forename: Courtney
authors.initials: C
authors.lastname: McCracken
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, United States.
authors.forename: Steven
authors.initials: S
authors.lastname: Yeh
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States.
authors.forename: Se Ryeong
authors.initials: SR
authors.lastname: Jang
authors.affiliation: Children's Healthcare of Atlanta, Atlanta, Georgia, United States.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Jenkins
authors.affiliation: Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States.
authors.forename: Spencer
authors.initials: S
authors.lastname: Cope
authors.affiliation: Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States.
authors.forename: John
authors.initials: J
authors.lastname: Bohnsack
authors.affiliation: Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States.
authors.forename: Aimee
authors.initials: A
authors.lastname: Hersh
authors.affiliation: Department of Pediatrics, Cincinnati Children's Medical Center, Cincinnati, Ohio, United States.
authors.forename: Susan D
authors.initials: SD
authors.lastname: Thompson
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States 2Children's Healthcare of Atlanta, Atlanta, Georgia, United States.
authors.forename: Sampath
authors.initials: S
authors.lastname: Prahalad
mesh_terms: D000483:Alleles; D001171:Arthritis, Juvenile / Q000150:complications / Q000235:genetics* / Q000276:immunology; D002675:Child, Preschool; D004247:DNA / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008297:Male; D014605:Uveitis / Q000150:complications / Q000235:genetics* / Q000276:immunology
chemical_list: D059811:HLA-DRB1 Chains; D004247:DNA