title: Baicalein protect pancreatic injury in rats with severe acute pancreatitis by inhibiting pro-inflammatory cytokines expression.
abstract: OBJECTIVE
  Inflammatory cytokines is a key point in the development of pathogenesis of SAP. Inflammatory mediators TNF-α and IL-6 are up-regulated in serum of patients with SAP and become good discriminators of SAP severity.
  
  
  METHODS
  In this study, we investigated the treatment effectiveness of Baicalein on SAP rat model. Baicalein was intravenously injected immediately after SAP induction in rats. The mortality, histopathology score, ascites fluid volume, and pro-inflammatory cytokine production were evaluated at 12 h after SAP induction.
  
  
  RESULTS
  Baicalein decreased the pancreatic histopathology score, reduced ascites fluid production, protected against pancreatic injury, and improved survival in rats with SAP. The serum IL-6 and TNF-α concentrations were also down-regulated by Baicalein.
  
  
  CONCLUSIONS
  Baicalein demonstrated a well curative capability on rats with SAP. The mechanism may be alleviateing pancreatic injury and inhibiting pro-inflammatory cytokines expression.
authors.affiliation: National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: lijun123@mail.xjtu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of General Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, 555 East Friendship Road, Xi'an 710054, Shaanxi Province, PR China. Electronic address: wuyongtao@163.com.
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Wu
authors.affiliation: National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China; Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: drzhangshu@163.com.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China; Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: zhangjian-937@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: jifanpu1979@163.com.
authors.forename: Fanpu
authors.initials: F
authors.lastname: Ji
authors.affiliation: National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: baishui09@sina.com.
authors.forename: Wangjun
authors.initials: W
authors.lastname: Bo
authors.affiliation: National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: gxiaoyan5999@163.com.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Guo
authors.affiliation: National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China; Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: lzf2568@gmail.com.
authors.forename: Zongfang
authors.initials: Z
authors.lastname: Li
mesh_terms: D000681:Amylases / Q000097:blood; D000818:Animals; D001201:Ascites / Q000517:prevention & control; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000097:blood; D004195:Disease Models, Animal; D044950:Flavanones / Q000008:administration & dosage / Q000494:pharmacology*; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors* / Q000097:blood; D007275:Injections, Intravenous; D008297:Male; D008516:Medicine, Chinese Traditional; D010195:Pancreatitis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016207:Cytokines; D044950:Flavanones; D018836:Inflammation Mediators; C006680:baicalein; D000681:Amylases
keywords: Baicalein; Pancreatic injury; Severe acute pancreatitis; Systemic inflammatory response