title: The impact of addiction medications on treatment outcomes for persons with co-occurring PTSD and opioid use disorders.
abstract: OBJECTIVE
  Previous research has been inconclusive about whether adding psychosocial treatment to medication assisted treatment (MAT) improves outcomes for patients with co-occurring psychiatric and opioid use disorders. This study evaluated the impact of MAT and psychosocial therapies on treatment outcomes for patients with co-occurring opioid use disorders and PTSD.
  
  
  METHODS
  Patients meeting criteria for PTSD and substance use disorders were randomly assigned to one of three treatment conditions: Standard Care (SC) alone, Integrated Cognitive Behavioral Therapy (ICBT) plus SC, or Individual Addiction Counseling (IAC) plus SC. Substance use and psychiatric symptoms were assessed at baseline and 6 months. Only patients with opioid use disorders were included in the present analyses (n = 126). Two-way ANOVAS and logistic regression analyses were used to examine associations between treatment conditions and MAT, for substance use and psychiatric outcomes.
  
  
  RESULTS
  MAT patients receiving ICBT had significantly decreased odds of a positive urine drug screen, compared to non-MAT patients receiving SC alone (OR = .07, 95% CI = .01, .81, p = .03). For PTSD symptoms, a significant MAT by psychosocial treatment condition interaction demonstrated that MAT patients had comparable declines in PTSD symptoms regardless of psychosocial treatment type (F(2, 88) = 4.74, p = .011). Non-MAT patients in ICBT had significantly larger reductions in PTSD.
  
  
  CONCLUSIONS
  For patients with co-occurring opioid use disorders and PTSD, MAT plus ICBT is associated with more significant improvement in substance use. For non-MAT patients, ICBT is most beneficial for PTSD symptoms.
authors.affiliation: Dartmouth Psychiatric Research Center, Lebanon, New Hampshire.|Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Saunders
authors.affiliation: Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.|Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Mark P
authors.initials: MP
authors.lastname: McGovern
authors.affiliation: Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Chantal
authors.initials: C
authors.lastname: Lambert-Harris
authors.affiliation: Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Andrea
authors.initials: A
authors.lastname: Meier
authors.affiliation: Dartmouth Psychiatric Research Center, Lebanon, New Hampshire.
authors.forename: Bethany
authors.initials: B
authors.lastname: McLeman
authors.affiliation: Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Haiyi
authors.initials: H
authors.lastname: Xie
mesh_terms: D000328:Adult; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003376:Counseling; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000150:complications / Q000188:drug therapy* / Q000628:therapy*; D010342:Patient Acceptance of Health Care; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D013313:Stress Disorders, Post-Traumatic / Q000150:complications / Q000188:drug therapy* / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D011619:Psychotropic Drugs
keywords: co-occurring disorders; integrated treatment; medication-assisted treatment; opioid dependence; posttraumatic stress disorder