title: [LABORATORY MARKERS FOR EARLY DIAGNOSIS OF NEONATAL SEPSIS].
abstract: Sepsis in neonates still remains difficult issue for clinicians. This review observes literature data about early laboratory diagnosis of neonatal sepsis. The paper considers the latest information about well-known methods of sepsis diagnosis in neonates such as complete blood count, acute phase reactants, cytokine markers, their advantages and disadvantages, as well as statistical value based on different meta-analysis and large multicenter investigations in many countries. We notified the newest methods in sepsis diagnosis such as plasma amyloid A, DAMP molecules, cell surface markers CD64, CD11b, and inter-a inhibitor proteins. The review informs about analysis of genomic and proteomic profile, nucleic acids tools. This data considering for early and late neonatal sepsis and their statistical values: sensitivity, specificity, positive and negative predictive value.
authors.forename: Y I
authors.initials: YI
authors.lastname: Kucherov
authors.forename: Y V
authors.initials: YV
authors.lastname: Zhirkova
authors.forename: L I
authors.initials: LI
authors.lastname: Chebotaeva
authors.forename: T V
authors.initials: TV
authors.lastname: Shishkina
mesh_terms: D000510:Alpha-Globulins / Q000032:analysis; D015415:Biomarkers / Q000032:analysis / Q000097:blood*; D002097:C-Reactive Protein; D039481:CD11b Antigen / Q000097:blood; D042241:Early Diagnosis; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D020543:Proteome / Q000235:genetics / Q000378:metabolism; D017452:Receptors, IgG / Q000097:blood; D018805:Sepsis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D000685:Serum Amyloid A Protein / Q000032:analysis
chemical_list: D000510:Alpha-Globulins; D015415:Biomarkers; D039481:CD11b Antigen; C485359:HP protein, human; D006242:Haptoglobins; C509295:ITGAM protein, human; D020543:Proteome; D017452:Receptors, IgG; D000685:Serum Amyloid A Protein; C011877:inter-alpha-inhibitor; D002097:C-Reactive Protein