title: Modeling of internal carotid artery aneurysm and blood flow simulation.
abstract: BACKGROUND
  The rupture of aneurysm is quite common in the clinics, and is hazardous to patients. Its occurrence is considered to be related to the hemodynamic abnormalities.
  
  
  OBJECTIVE
  To construct the model of internal carotid artery aneurysm (ICA-A), and have a simulation of blood flow.
  
  
  METHODS
  Based on the CTA data from spiral CT scan, the ICA-A model was constructed, and the types of blood flow, wall shear stress (WSS), Von Mises stress (VMS) and pressure were simulated and calculated.
  
  
  RESULTS
  ICA-A model has been built and shape is the same morphology as CT 3D-image. In the whole cardiac cycle, the blood flow of aneurysm body is swirl, its velocity is slower than that of aneurysm neck; the maximum deformation, wall shear stress, pressure and von mises stress of aneurysm wall is at the neck, the minimum is at the top. The highest value appeared at 0.52 s in the cardiac cycle of 0.74 s, the lowest is at 0.21 s.
  
  
  CONCLUSIONS
  It is effective and practical to construct the model of ICA-A base on CTA data. Blood flow simulation of ICA-A will provide new basis for the study on the occurrence and development of aneurysm.
authors.forename: Bingqiang
authors.initials: B
authors.lastname: Xu
authors.forename: Hua
authors.initials: H
authors.lastname: Zhong
authors.forename: Shaoyin
authors.initials: S
authors.lastname: Duan
mesh_terms: D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D018056:Hemorheology; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008955:Models, Cardiovascular; D013314:Stress, Mechanical; D036542:Tomography, Spiral Computed
keywords: Internal carotid artery; aneurysm; blood flow simulation; finite element modeling