title: Extracts of passion fruit peel and seed of Passiflora edulis (Passifloraceae) attenuate oxidative stress in diabetic rats.
abstract: This study was aimed at evaluating the anti-diabetic potential of passion fruit Passiflora edulis (EPE) extracts in diabetic rats, following Streptozotocin (STZ) induced oxidative stress. Thirty adult Wistar rats were divided into five groups, with six rats in each group. The control rats were injected intraperitoneally with citrate buffer (pH 4.5). The remaining groups of rats were administered single dose of 45 mg·kg(-1) of STZ by intraperitoneal route to induce diabetes. The diabetic animals were treated with 250 and 500 mg·kg(-1) of EPE and glibenclamide 0.6 mg·kg(-1) for fifteen days by oral route. Blood glucose, end organ oxidative stress marker, and anti-oxidants were assayed. Further, histopathological investigation of pancreas was studied at the end of the experimentation. The results revealed that subacute administration of EPE significantly (P < 0.001) controlled the blood glucose level in the diabetic rats. In addition, EPE extract protected the end organs by restoring the anti-oxidants enzyme, significantly increasing super oxide dismutase level (SOD) and decreasing catalase (CAT) and TBARS level in visceral organs. In conclusion, that EPE extracts showed anti-diabetic and anti-oxidant potential against streptozotocin-induced diabetes.
authors.affiliation: Faculty of Biomedical Sciences, Asia Metropolitan University, Cheras, Selangor, Malaysia.
authors.forename: Salanee
authors.initials: S
authors.lastname: Kandandapani
authors.affiliation: Faculty of Pharmacy, Asia Metropolitan University, Cheras, Selangor, Malaysia.
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Balaraman
authors.affiliation: Faculty of Pharmacy, Asia Metropolitan University, Cheras, Selangor, Malaysia. Electronic address: hajanazeer@amu.edu.my.
authors.forename: Haja N
authors.initials: HN
authors.lastname: Ahamed
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005638:Fruit; D007328:Insulin / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D029598:Passiflora; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D017208:Rats, Wistar; D012639:Seeds; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000930:Antidiarrheals; D000975:Antioxidants; D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D002374:Catalase; D013482:Superoxide Dismutase
keywords: Anti-oxidant enzymes; Diabetic rats; Oxidative stress; Reactive oxygen species; Streptozotocin; Visceral organs