title: Designing Dendrimer and Miktoarm Polymer Based Multi-Tasking Nanocarriers for Efficient Medical Therapy.
abstract: To address current complex health problems, there has been an increasing demand for smart nanocarriers that could perform multiple complimentary biological tasks with high efficacy. This has provoked the design of tailor made nanocarriers, and the scientific community has made tremendous effort in meeting daunting challenges associated with synthetically articulating multiple functions into a single scaffold. Branched and hyper-branched macromolecular architectures have offered opportunities in enabling carriers with capabilities including location, delivery, imaging etc. Development of simple and versatile synthetic methodologies for these nanomaterials has been the key in diversifying macromolecule based medical therapy and treatment. This review highlights the advancement from conventional "only one function" to multifunctional nanomedicine. It is achieved by synthetic elaboration of multivalent platforms in miktoarm polymers and dendrimers by physical encapsulation, covalent linking and combinations thereof.
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada. anjali.25sept@gmail.com.
authors.forename: Anjali
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada. ashok.kakkar@mcgill.ca.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kakkar
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D004337:Drug Carriers
keywords: dendrimers; drug delivery; miktoarm polymers; multifunctional; nanocarriers; nanomedicine