title: Routine use of daily oral vitamin K to treat infants with cystic fibrosis.
abstract: Vitamin K is routinely administered after birth in the UK to prevent haemorrhagic disease of the newborn. Despite this, vitamin K-deficient coagulopathy still occurs in infants with high morbidity and mortality. Up to 50% of late onset bleeding presents with intracranial haemorrhage. The risk of developing vitamin K coagulopathy is higher in infants with cystic fibrosis (CF) and those that are exclusively breast fed due to low vitamin K levels in breast milk and intestinal changes in bacterial flora. Oral vitamin K supplementation is a simple addition to routine CF treatment during infancy to prevent complications from significant coagulopathy.
authors.affiliation: UK National Institute for Health Research Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire SO16 6YD, UK.
authors.forename: Sophie T
authors.initials: ST
authors.lastname: Cottam
authors.affiliation: UK National Institute for Health Research Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire SO16 6YD, UK; Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire SO16 6YD, UK. Electronic address: gary.connett@uhs.nhs.uk.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Connett
mesh_terms: D000284:Administration, Oral; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D014057:Tomography, X-Ray Computed; D014812:Vitamin K / Q000008:administration & dosage / Q000627:therapeutic use*; D014813:Vitamin K Deficiency / Q000150:complications / Q000188:drug therapy*; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014815:Vitamins; D014812:Vitamin K
keywords: Cystic Fibrosis; Vitamin K