title: The andrologist's contribution to a better life for ageing men: part 1.
abstract: The present opinion paper, explores the possibility that optimal hormone treatment and judicious nutraceutical food supplement can help ageing men to gain quality-adjusted life years. Testosterone treatment of patients with late-onset hypogonadism is given via the transdermal route or by intramuscular injections. There is overwhelming evidence that testosterone replacement therapy (TRT) has many beneficial effects and increases longevity by approximately 2% per year. On the basis of knowledge of physiology, animal and human experimental data, we explain why TRT reduces the risk of cardiovascular disease and of prostate cancer. However, the total testosterone load supplied per day should remain within the physiological range, and new galenical formulations should be developed, mimicking normal day-night variations.
authors.affiliation: Department of Endocrinology, University Hospital Gent, Gent, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Comhaire
authors.affiliation: Department of Endocrinology, University Hospital Gent, Gent, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Mahmoud
mesh_terms: D000375:Aging; D000728:Androgens / Q000627:therapeutic use*; D033441:Andrology; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D019587:Dietary Supplements; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D000067562:Late Onset Disorders / Q000188:drug therapy; D008136:Longevity; D008297:Male; D010819:Physician's Role; D013629:Tamoxifen / Q000627:therapeutic use; D013739:Testosterone / Q000627:therapeutic use*
chemical_list: D000728:Androgens; D047072:Aromatase Inhibitors; D004965:Estrogen Antagonists; D013629:Tamoxifen; D013739:Testosterone
keywords: Antioxidants; hormones; nutraceutical; quality-adjusted life years; testosterone