title: Successful long-term mandibular reconstruction and rehabilitation using non-vascularised autologous bone graft and recombinant human BMP-7 with subsequent endosseous implant in a patient with bisphosphonate-related osteonecrosis of the jaw.
abstract: We describe a case of extensive osteonecrosis of the mandible after a dental extraction in a 71-year-old woman who was taking alendronic acid (Fosamax(®), Merck) for osteoporosis. Bone damaged by bisphosphonate-related osteonecrosis of the jaw (BRONJ), also now known as medication-related osteonecrosis of the jaw (MRONJ), can be regenerated and filled with endosseous implants using non-vascularised autologous grafts.
authors.affiliation: Regional North West London Maxillofacial Unit, Northwick Park Hospital, London, United Kingdom. Electronic address: ishrat.rahim@nhs.net.
authors.forename: Ishrat
authors.initials: I
authors.lastname: Rahim
authors.affiliation: Regional North West London Maxillofacial Unit, Northwick Park Hospital, London, United Kingdom. Electronic address: s.salt@nhs.net.
authors.forename: Stephen
authors.initials: S
authors.lastname: Salt
authors.affiliation: Regional North West London Maxillofacial Unit, Northwick Park Hospital, London, United Kingdom. Electronic address: manolis.heliotis@nhs.net.
authors.forename: Manolis
authors.initials: M
authors.lastname: Heliotis
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D055419:Bone Morphogenetic Protein 7; D016025:Bone Transplantation; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D063175:Mandibular Reconstruction; D014182:Transplantation, Autologous
chemical_list: C525819:BMP7 protein, human; D050071:Bone Density Conservation Agents; D055419:Bone Morphogenetic Protein 7; D004164:Diphosphonates
keywords: BMPs; BRONJ; Bisphosphonates; Bone morphogenic proteins; Endosseous implants; MRONJ; Mandibular reconstruction