title: Development of a medication adherence scale for familial Mediterranean fever (MASIF) in a cohort of Turkish children.
abstract: OBJECTIVE
  To develop and assess the validity and reliability of an adherence scale concerning medical treatment in paediatric FMF patients.
  
  
  METHODS
  The Medication Adherence Scale in FMF Patients (MASIF) is a 18-item questionnaire that evaluates adherence to medication in four domains. Validation of the instrument was accomplished in paediatric FMF patients (aged 2-18 years) under medication at least for 6 months. The first step was to build up the scale through qualitative approach (with interviews using semi-structured questions). Validation analyses included assessment of feasibility, face and content validity; construct validity, internal consistency and test-retest reliability.
  
  
  RESULTS
  One hundred and fifty patients with FMF were enrolled in the study. The mean age of the patients was 11.11±4.02 years and 48.7% of them were male. The MASIF was found to be feasible and valid for both face and content. It correlated with the Morisky Medication Adherence Scale as a gold standard thereby demonstrating good construct validity (r=0.515, p<0.001). Assessment of content validity identified four subscales. The internal consistency, Cronbach's alpha was 0.728. There was a positive and significant correlation between test and retest scores (r=0.843; p<0.001). Also, a significant correlation between parents' and children's reports (r=0.781, p<0.001).
  
  
  CONCLUSIONS
  Based on these results, the use of this scale to assess and follow up the adherence to treatment in paediatric FMF patients under medical treatment is recommended.
authors.affiliation: Gulhane Military Medical Academy, Department of Family Medicine, Ankara, Turkey.
authors.forename: Sirzat
authors.initials: S
authors.lastname: Yesilkaya
authors.affiliation: Gulhane Military Medical Faculty, Department of Biostatistics, Ankara, Turkey.
authors.forename: Cengizhan
authors.initials: C
authors.lastname: Acikel
authors.affiliation: Gulhane Military Medical Academy, School of Nursing, Ankara, Turkey, Turkey.
authors.forename: Berna Eren
authors.initials: BE
authors.lastname: Fidanci
authors.affiliation: Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Polat
authors.affiliation: Ege University Faculty of Medicine, Pediatric Rheumatology, Izmir, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Sozeri
authors.affiliation: Kanuni Sultan Suleyman Research and Training Hospital, Pediatric Nephrology-Rheumatology, Istanbul, Turkey.
authors.forename: Nuray Aktay
authors.initials: NA
authors.lastname: Ayaz
authors.affiliation: Dokuz Eylul University Hospital, Department of Pediatrics, İzmir, Turkey.
authors.forename: Balahan Bora
authors.initials: BB
authors.lastname: Makay
authors.affiliation: Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey.
authors.forename: Dogan
authors.initials: D
authors.lastname: Simsek
authors.affiliation: Sisli Etfal Education and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
authors.forename: Nurver
authors.initials: N
authors.lastname: Akinci
authors.affiliation: Sisli Etfal Education and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
authors.forename: Gul
authors.initials: G
authors.lastname: Özçelik
authors.affiliation: Dokuz Eylul University Hospital, Department of Pediatrics, İzmir, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Kavukçu
authors.affiliation: Istanbul University, Department of Pediatrics, Istanbul, Turkey.
authors.forename: Sevinc
authors.initials: S
authors.lastname: Emre
authors.affiliation: Uludag University Medical Faculty, Dept. of Pediatric Rheumatology, Bursa, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Donmez
authors.affiliation: Akdeniz University, Department of Pediatrics, Mersin, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Delibas
authors.affiliation: Pamukkale University Medical Faculty, Dept. of Paediatrics, Denizli, Turkey.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Yüksel
authors.affiliation: Ege University Faculty of Medicine, Pediatric Rheumatology, Izmir, Turkey.
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
authors.affiliation: Erciyes University Medical Faculty, Department of Paediatrics, Kayseri, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Poyrazoglu
authors.affiliation: Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Saldir
authors.affiliation: Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey.
authors.forename: Kursat
authors.initials: K
authors.lastname: Fidanci
authors.affiliation: Ministry of Health Dıskapı Children's Hospital, Paediatric Nephrology, Ankara, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Çakar
authors.affiliation: Selcuk University, Department of Paediatrics, Ankara, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Peru
authors.affiliation: Gazi Universty, Department of Paediatrics, Ankara, Turkey.
authors.forename: Sevcan
authors.initials: S
authors.lastname: Bakkaloglu
authors.affiliation: Inonu University, Paediatric Nephrology, Malatya, Turkey.
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Tabel
authors.affiliation: Gulhane Military Medical Academy, Department of Family Medicine, Ankara, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Sari
authors.affiliation: Gulhane Military Medical Academy, Department of Family Medicine, Ankara, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Aydogan
authors.affiliation: Gulhane Military Medical Academy, Department of Family Medicine, Ankara, Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Ozenc
authors.affiliation: Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey.
authors.forename: Gokalp
authors.initials: G
authors.lastname: Basbozkurt
authors.affiliation: Dokuz Eylul University Hospital, Department of Pediatrics, İzmir, Turkey.
authors.forename: Erbil
authors.initials: E
authors.lastname: Unsal
authors.affiliation: Istanbul University, Department of Pediatrics, Istanbul, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kasapcopur
authors.affiliation: Gulhane Military Medical Faculty, Paediatric Rheumatology Unit, Ankara, Turkey.
authors.forename: Faysal
authors.initials: F
authors.lastname: Gok
authors.affiliation: Hacettepe University, Paediatric Nephrology and Rheumatology Unit, Ankara, Turkey.
authors.forename: Seza
authors.initials: S
authors.lastname: Ozen
authors.affiliation: Gulhane Military Medical Faculty, Paediatric Rheumatology Unit, Ankara; and Gulhane Military Medical Academy, FMF Arthritis Vasculitis and Orphan disease Research in Paediatric Rheumatology, Ankara, Turkey. erkandemirkaya@yahoo.com.
authors.forename: Erkan
authors.initials: E
authors.lastname: Demirkaya
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D010505:Familial Mediterranean Fever / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007407:Interviews as Topic; D008297:Male; D055118:Medication Adherence; D036301:Qualitative Research; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
chemical_list: D007166:Immunosuppressive Agents