title: Quo Vadis Clozapine? A Bibliometric Study of 45 Years of Research in International Context.
abstract: We have carried out a bibliometric study about the international scientific publications on clozapine. We have used the EMBASE and MEDLINE databases, and we applied bibliometric indicators of production, as Price's Law on the increase of scientific literature. We also calculated the participation index (PI) of the different countries. The bibliometric data have also been correlated with some social and health data from the 12 most productive countries in biomedicine and health sciences. In addition, 5607 original documents dealing with clozapine, published between 1970 and 2013, were downloaded. Our results state non-fulfilment of Price's Law, with scientific production on clozapine showing linear growth (r=0.8691, vs. r=0.8478 after exponential adjustment). Seven of the 12 journals with the highest numbers of publications on clozapine have an Impact Factor>2. Among the countries generating clozapine research, the most prominent is the USA (PI=24.32), followed by the UK (PI=6.27) and Germany (PI=5.40). The differences among countries on clozapine research are significantly related to economic variables linked to research. The scientific interest in clozapine remains remarkable, although after the application of bibliometric indicators of production, a saturation point is evident in the growth of scientific literature on this topic.
authors.affiliation: Faculty of Health Sciences and Chair of Genomic Medicine, Camilo José Cela University, C/Castillo de Alarcón, 49, Urb. Villafranca del Castillo, 28692 Villanueva de la Cañada, Madrid, Spain. flopez@ucjc.edu.|Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Campus Universitario-C/19, Ctra. Madrid-Barcelona, Km. 33,600, 28871 Alcalá de Henares, Madrid, Spain. flopez@ucjc.edu.|Neuropsychopharmacology Unit, "Hospital 12 de Octubre" Research Institute, Avda. Córdoba, s/n, Madrid 28041, Spain. flopez@ucjc.edu.
authors.forename: Francisco
authors.initials: F
authors.lastname: López-Muñoz
authors.affiliation: Neuropsychopharmacology Unit, "Hospital 12 de Octubre" Research Institute, Avda. Córdoba, s/n, Madrid 28041, Spain. fjavisanzf@gmail.com.|Department of Psychiatry, 12 de Octubre University Hospital, Avda. Córdoba, s/n, Madrid 28041, Spain. fjavisanzf@gmail.com.|Biomedical Research Center Network for Mental Health (CIBERSAM), Madrid 28029, Spain. fjavisanzf@gmail.com.
authors.forename: Javier
authors.initials: J
authors.lastname: Sanz-Fuentenebro
authors.affiliation: Neuropsychopharmacology Unit, "Hospital 12 de Octubre" Research Institute, Avda. Córdoba, s/n, Madrid 28041, Spain. gabriel.rubio@salud.madrid.org.|Department of Psychiatry, 12 de Octubre University Hospital, Avda. Córdoba, s/n, Madrid 28041, Spain. gabriel.rubio@salud.madrid.org.|Department of Psychiatry, Complutense University, Plaza de Ramón y Cajal, s/n, Ciudad Universitaria, Madrid 28040, Spain. gabriel.rubio@salud.madrid.org.|Networks for Cooperative Research in Health (RETICS-Addictive Disorder Network), Institute of Health Carlos III (ISCIII), MICINN and FEDER, Madrid 28029, Spain. gabriel.rubio@salud.madrid.org.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rubio
authors.affiliation: Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Campus Universitario-C/19, Ctra. Madrid-Barcelona, Km. 33,600, 28871 Alcalá de Henares, Madrid, Spain. pigarcia@grupojuste.com.
authors.forename: Pilar
authors.initials: P
authors.lastname: García-García
authors.affiliation: Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Campus Universitario-C/19, Ctra. Madrid-Barcelona, Km. 33,600, 28871 Alcalá de Henares, Madrid, Spain. cecilioalamo@hotmail.com.
authors.forename: Cecilio
authors.initials: C
authors.lastname: Álamo
mesh_terms: D014150:Antipsychotic Agents / Q000266:history / Q000627:therapeutic use*; D015706:Bibliometrics; D035843:Biomedical Research / Q000266:history; D003024:Clozapine / Q000266:history / Q000627:therapeutic use*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D055811:Journal Impact Factor; D016239:MEDLINE; D012559:Schizophrenia / Q000188:drug therapy* / Q000266:history
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine
keywords: atypical antipsychotics; bibliometry; clozapine; schizophrenia; second-generation antipsychotics