title: Folate receptor autoantibodies in pregnancy related complications.
abstract: BACKGROUND
  Folate receptor autoantibodies in women have been associated with neural tube pregnancy and in children with cerebral folate deficiency syndrome and autism. These autoantibodies have been implicated in blocking folate transport to the fetus and to the brain in infants.
  
  
  METHODS
  We report a woman with multiple pregnancy related complications who was diagnosed with autoantibodies to the folate receptor alpha.
  
  
  RESULTS
  A treatment strategy with folate supplementation and reducing the antibody titer proved effective in normal pregnancy outcome.
  
  
  CONCLUSIONS
  This long-term follow up of a subject with folate receptor autoantibodies is a first report of its kind and describes treatment strategy to prevent pregnancy related complications due to folate receptor autoantibodies.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, SUNY-Downstate Medical Center, Brooklyn, New York.
authors.forename: Iuliana
authors.initials: I
authors.lastname: Shapira
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, SUNY-Downstate Medical Center, Brooklyn, New York.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Sequeira
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, SUNY-Downstate Medical Center, Brooklyn, New York.
authors.forename: Edward V
authors.initials: EV
authors.lastname: Quadros
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D058975:Folate Receptor 1 / Q000276:immunology*; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D058975:Folate Receptor 1; D005492:Folic Acid
keywords: autoantibodies; developmental disorders; folate receptor; folic acid; pregnancy