title: Influence of pre-pregnancy obesity on the development of macrosomia and large for gestational age in women with or without gestational diabetes mellitus in Chinese population.
abstract: OBJECTIVE
  To determine the effects of gestational diabetes mellitus (GDM) and pre-pregnancy obesity on macrosomia and large for gestational age (LGA).
  
  
  METHODS
  We conducted a prospective cohort study of 587 GDM women and 478 non-GDM women from 2012 to 2013. We collected their data of the pre-pregnancy weight, sociodemographic data, medical histories, clinical treatment, and followed-up the outcomes of delivery including birth weight. Multiple logistic regression models were used to test associations between pre-pregnant obesity and macrosomia/LGA and between GDM and macrosomia/LGA.
  
  
  RESULTS
  Of 1065 women we studied, obese women had 4.17 times and 2.27 times increased risk of developing macrosomia (95% CI: 2.52 to 6.91) and LGA (95% CI: 1.60 to 3.21), respectively, than non-obese women after adjustment for maternal age, gestational weeks and GDM. We did not find GDM is a risk factor for macrosomia or LGA after GDM treatment.
  
  
  CONCLUSIONS
  Pre-pregnancy obesity accounts for a high prevalence of macrosomia. Interventions that focus on pre-pregnancy obesity have the potential to reach far more women at risk of macrosomia.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.|Department of Child, Adolescent and Women's Health, School of Public Health, Peking University Health Science Center, Beijing, China.
authors.forename: L-F
authors.initials: LF
authors.lastname: Wang
authors.affiliation: Department of Child, Adolescent and Women's Health, School of Public Health, Peking University Health Science Center, Beijing, China.|Key Laboratory of Reproductive Health, Ministry of Health, Beijing, China.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Department of Child, Adolescent and Women's Health, School of Public Health, Peking University Health Science Center, Beijing, China.|Health Management Center, Xinjiang Medical University, Xinjiang, China.
authors.forename: D
authors.initials: D
authors.lastname: Ao
authors.affiliation: Department of Child, Adolescent and Women's Health, School of Public Health, Peking University Health Science Center, Beijing, China.|Key Laboratory of Reproductive Health, Ministry of Health, Beijing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Child, Adolescent and Women's Health, School of Public Health, Peking University Health Science Center, Beijing, China.|Key Laboratory of Reproductive Health, Ministry of Health, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
authors.forename: H-X
authors.initials: HX
authors.lastname: Yang
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002681:China; D016640:Diabetes, Gestational / Q000453:epidemiology*; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology*; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult