title: Low-calorie sweeteners in food and food supplements on the Italian market.
abstract: This study determines the occurrence and concentration levels of artificial low-calorie sweeteners (LCSs) in food and food supplements on the Italian market. The analysed sample set (290 samples) was representative of the Italian market and comprised of beverages, jams, ketchups, confectionery, dairy products, table-top sweeteners and food supplements. All samples were analysed via UPLC-MS/MS. The method was in-house validated for the analysis of seven LCSs (aspartame, acesulfame-K, saccharin, sucralose, cyclamate, neotame and neohesperidin dihydrochalcone) in food and for five LCSs (aspartame, acesulfame-K, saccharin, cyclamate and sucralose) in food supplements. Except for cyclamate in one beverage which exceeded the maximum level (ML) with 13%, all concentrations measured in food were around or below the ML. In food supplements, 40 of the 52 samples (77%) were found to be above the ML, with exceedances of up to 200% of the ML.
authors.affiliation: a Department of Food, Medicines and Consumer Safety, Service of Consumer Safety , Scientific Institute of Public Health , Brussels , Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: Janvier
authors.affiliation: a Department of Food, Medicines and Consumer Safety, Service of Consumer Safety , Scientific Institute of Public Health , Brussels , Belgium.
authors.forename: Séverine
authors.initials: S
authors.lastname: Goscinny
authors.affiliation: b Research Center on Food and Nutrition , Council for Agricultural Research and Economics , Rome , Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Le Donne
authors.affiliation: a Department of Food, Medicines and Consumer Safety, Service of Consumer Safety , Scientific Institute of Public Health , Brussels , Belgium.
authors.forename: Joris
authors.initials: J
authors.lastname: Van Loco
mesh_terms: D001218:Aspartame / Q000032:analysis; D002853:Chromatography, Liquid; D003494:Cyclamates / Q000032:analysis; D004032:Diet; D019587:Dietary Supplements / Q000032:analysis*; D004151:Dipeptides / Q000032:analysis; D002149:Energy Intake; D005503:Food Additives / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis; D006569:Hesperidin / Q000031:analogs & derivatives / Q000032:analysis; D006801:Humans; D007558:Italy; D012439:Saccharin / Q000032:analysis; D013549:Sweetening Agents / Q000032:analysis*; D053719:Tandem Mass Spectrometry; D013843:Thiazines / Q000032:analysis
chemical_list: D003494:Cyclamates; D004151:Dipeptides; D005503:Food Additives; D013549:Sweetening Agents; D013843:Thiazines; D006569:Hesperidin; D012439:Saccharin; C006362:acetosulfame; C546526:neohesperidin; C404525:neotame; D001218:Aspartame
keywords: Italian market; acesulfame-K; aspartame; cyclamate; food; food supplements; neohesperidin dihydrochalcone; neotame; occurrence; saccharin; sucralose; sweeteners