title: Circulating S100B and Adiponectin in Children Who Underwent Open Heart Surgery and Cardiopulmonary Bypass.
abstract: BACKGROUND
  S100B protein, previously proposed as a consolidated marker of brain damage in congenital heart disease (CHD) newborns who underwent cardiac surgery and cardiopulmonary bypass (CPB), has been progressively abandoned due to S100B CNS extra-source such as adipose tissue. The present study investigated CHD newborns, if adipose tissue contributes significantly to S100B serum levels.
  
  
  METHODS
  We conducted a prospective study in 26 CHD infants, without preexisting neurological disorders, who underwent cardiac surgery and CPB in whom blood samples for S100B and adiponectin (ADN) measurement were drawn at five perioperative time-points.
  
  
  RESULTS
  S100B showed a significant increase from hospital admission up to 24 h after procedure reaching its maximum peak (P < 0.01) during CPB and at the end of the surgical procedure. Moreover, ADN showed a flat pattern and no significant differences (P > 0.05) have been found all along perioperative monitoring. ADN/S100B ratio pattern was identical to S100B alone with the higher peak at the end of CPB and remained higher up to 24 h from surgery.
  
  
  CONCLUSIONS
  The present study provides evidence that, in CHD infants, S100B protein is not affected by an extra-source adipose tissue release as suggested by no changes in circulating ADN concentrations.
authors.affiliation: Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, Via Morandi 30, 20097 San Donato Milanese, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Varrica
authors.affiliation: Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, Via Morandi 30, 20097 San Donato Milanese, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Satriano
authors.affiliation: Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, Via Morandi 30, 20097 San Donato Milanese, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Frigiola
authors.affiliation: Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, Via Morandi 30, 20097 San Donato Milanese, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giamberti
authors.affiliation: Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, Via Morandi 30, 20097 San Donato Milanese, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Tettamanti
authors.affiliation: Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, Via Morandi 30, 20097 San Donato Milanese, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Anastasia
authors.affiliation: Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, Via Morandi 30, 20097 San Donato Milanese, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Conforti
authors.affiliation: Department of Pediatrics, Neonatology and Child Neurology, Maastricht University, P. Debyelaan 25, 5800 Maastricht, Netherlands.
authors.forename: Antonio D W
authors.initials: AD
authors.lastname: Gavilanes
authors.affiliation: Department of Pediatrics, Neonatology and Child Neurology, Maastricht University, P. Debyelaan 25, 5800 Maastricht, Netherlands.
authors.forename: Luc J
authors.initials: LJ
authors.lastname: Zimmermann
authors.affiliation: Department of Pediatrics, Neonatology and Child Neurology, Maastricht University, P. Debyelaan 25, 5800 Maastricht, Netherlands.
authors.forename: Hans J S
authors.initials: HJ
authors.lastname: Vles
authors.affiliation: Department of Drug Sciences, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Li Volti
authors.affiliation: Department of Maternal Fetal and Neonatal Medicine, C. Arrigo Children's Hospital, Spalto Marengo 46, 15100 Alessandria, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Gazzolo
mesh_terms: D052242:Adiponectin / Q000097:blood*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human