title: Microbubble-mediated intravascular ultrasound imaging and drug delivery.
abstract: Intravascular ultrasound (IVUS) provides radiation-free, real-time imaging and assessment of atherosclerotic disease in terms of anatomical, functional, and molecular composition. The primary clinical applications of IVUS imaging include assessment of luminal plaque volume and real-time image guidance for stent placement. When paired with microbubble contrast agents, IVUS technology may be extended to provide nonlinear imaging, molecular imaging, and therapeutic delivery modes. In this review, we discuss the development of emerging imaging and therapeutic applications that are enabled by the combination of IVUS imaging technology and microbubble contrast agents.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Dixon
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Kilroy
authors.forename: Ali H
authors.initials: AH
authors.lastname: Dhanaliwala
authors.forename: Johnny L
authors.initials: JL
authors.lastname: Chen
authors.forename: Linsey C
authors.initials: LC
authors.lastname: Phillips
authors.forename: Michael
authors.initials: M
authors.lastname: Ragosta
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Klibanov
authors.forename: Brian R
authors.initials: BR
authors.lastname: Wamhoff
authors.forename: John A
authors.initials: JA
authors.lastname: Hossack
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D045423:Microbubbles; D011817:Rabbits; D013552:Swine; D018084:Ultrasonography, Interventional / Q000379:methods*