title: [Impacts of high-volume hemofiltration on hemodynamics and vascular endothelial permeability in children with septic shock].
abstract: OBJECTIVE
  To investigate the effects of high-volume hemofiltration (HVHF) on hemodynamics, vasoactive factors, and vascular endothelial permeability in children with septic shock by a comparative analysis.
  
  
  METHODS
  Thirty-six children who were diagnosed with septic shock between January 2013 and September 2014 were randomly divided into control and observation groups (n=18 each). Children in the control group were treated with the standard-volume hemofiltration (SVHF), while children in the observation group were treated with HVHF. The hemodynamic indices and levels of vasoactive factors including 6-keto-prostaglandin F1α (6-keto-PGF1α), thromboxane B2 (TXB2), soluble E-selectin (sE-selectin), and endothelium-derived relaxing factor (EDRF) were determined before and after treatment. In addition, the effects of ultrafiltrate on endothelial cell permeability were assessed.
  
  
  RESULTS
  Compared with the control group, the observation group had significantly higher mean arterial pressure, significantly higher blood oxygen saturation, and a significantly lower heart rate after treatment (P<0.05). The levels of TXB2 and sE-selectin were significantly lower in the observation group than in the control group (P<0.05), while the levels of 6-keto-PGF1α and EDRF were significantly higher in the observation group than in the control group (P<0.05). Compared with the control group, the ultrafiltrate significantly attenuated the transepithelial electrical resistance in the observation group (P<0.05).
  
  
  CONCLUSIONS
  Compared with SVHF, HVHF is a more effective approach for improving the hemodynamics and levels of vasoactive factors and reducing the vascular endothelial permeability in children with septic shock.
authors.affiliation: Pediatric Intensive Care Unit, Guangzhou Women and Childrenγs Medical Center, Guangzhou 510623, China. 917589592@qq.com.
authors.forename: Xun
authors.initials: X
authors.lastname: Si-Tu
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Zhang
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Tao
authors.forename: Yan-Lan
authors.initials: YL
authors.lastname: Wu
authors.forename: Jian-Bin
authors.initials: JB
authors.lastname: Zheng
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D002199:Capillary Permeability; D002648:Child; D002675:Child, Preschool; D011464:Epoprostenol / Q000502:physiology; D005260:Female; D006439:Hemodynamics; D006440:Hemofiltration; D006801:Humans; D007223:Infant; D008297:Male; D012772:Shock, Septic / Q000503:physiopathology*; D013928:Thromboxane A2 / Q000502:physiology
chemical_list: D013928:Thromboxane A2; D011464:Epoprostenol