title: In Vitro Antibiotic Susceptibility of Initial Pseudomonas aeruginosa Isolates From United States Cystic Fibrosis Patients.
abstract: Chronic antibiotic suppression of cystic fibrosis (CF) infections has increased in the United States, as has isolation of Pseudomonas aeruginosa with reduced antibiotic susceptibility. However, analysis of the susceptibilities of 193 initial P aeruginosa clinical isolates suggests that antibiotic susceptibilities are comparable with wild-type strains despite expanded antipseudomonal treatment in the CF community.
authors.affiliation: Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Donald R
authors.initials: DR
authors.lastname: VanDevanter
authors.affiliation: Seattle Children's Research Institute.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Van Dalfsen
authors.affiliation: Infectious Diseases, Seattle Children's Hospital Pediatrics, University of Washington, Seattle.
authors.forename: Jane L
authors.initials: JL
authors.lastname: Burns
authors.affiliation: Pediatrics, University of Washington, Seattle Biomedical Statistics, Seattle Children's Research Institute, Washington.
authors.forename: Nicole
authors.initials: N
authors.lastname: Mayer-Hamblett
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology*; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents
keywords: cystic fibrosis; initial P aeruginosa; susceptibility