title: Chemoselective reduction of the phosphoryl bond of O-alkyl phosphinates and related compounds: an apparently impossible transformation.
abstract: A method is reported for the phosphoryl bond cleavage of O-alkyl phosphinates, phosphinothioates and certain phosphonamidates to furnish the corresponding P(III) borane adducts. The two-step procedure relies upon initial activation of the phosphoryl bond with an alkyl triflate, followed by reduction of the resulting intermediate using lithium borohydride.
authors.affiliation: Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. declan.gilheany@ucd.ie.
authors.forename: Niall P
authors.initials: NP
authors.lastname: Kenny
authors.affiliation: Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. declan.gilheany@ucd.ie.
authors.forename: Kamalraj V
authors.initials: KV
authors.lastname: Rajendran
authors.affiliation: Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. declan.gilheany@ucd.ie.
authors.forename: Declan G
authors.initials: DG
authors.lastname: Gilheany