title: Short term Heart Rate Variability to predict blood pressure drops due to standing: a pilot study.
abstract: BACKGROUND
  Standing from a bed or chair may cause a significant lowering of blood pressure (ΔBP), which may have severe consequences such as, for example, falls in older subjects. The goal of this study was to develop a mathematical model to predict the ΔBP due to standing in healthy subjects, based on their Heart Rate Variability, recorded in the 5 minutes before standing.
  
  
  METHODS
  Heart Rate Variability was extracted from an electrocardiogram, recorded from 10 healthy subjects during the 5 minutes before standing. The blood pressure value was measured before and after rising. A mathematical model aiming to predict ΔBP based on Heart Rate Variability measurements was developed using a robust multi-linear regression and was validated with the leave-one-subject-out cross-validation technique.
  
  
  RESULTS
  The model predicted correctly the ΔBP in 80% of experiments, with an error below the measurement error of sphygmomanometer digital devices (± 4.5 mmHg), a false negative rate of 7.5% and a false positive rate of 10%. The magnitude of the ΔBP was associated with a depressed and less chaotic Heart Rate Variability pattern.
  
  
  CONCLUSIONS
  The present study showes that blood pressure lowering due to standing can be predicted by monitoring the Heart Rate Variability in the 5 minutes before standing.
authors.forename: G
authors.initials: G
authors.lastname: Sannino
authors.forename: P
authors.initials: P
authors.lastname: Melillo
authors.forename: S
authors.initials: S
authors.lastname: Stranges
authors.forename: G
authors.initials: G
authors.lastname: De Pietro
authors.forename: L
authors.initials: L
authors.lastname: Pecchia
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D064368:Healthy Volunteers; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007024:Hypotension, Orthostatic; D008297:Male; D008962:Models, Theoretical; D010865:Pilot Projects; D055815:Young Adult