title: Thoracic endovascular repair (TEVAR) versus open surgery for blunt traumatic thoracic aortic injury.
abstract: BACKGROUND
  Blunt traumatic thoracic aortic injury (BTAI) is a life-threatening surgical emergency associated with mortality up to 8000 per year, most commonly caused by rapid acceleration/deceleration injury sustained through motor vehicle accident and/or blunt thoracic trauma. BTAI has high pre-hospital mortality following the primary injury, with only 10% to 15% of patients surviving long enough to reach the hospital. Open surgical repair had remained the standard treatment option for BTAI since successfully introduced in 1959. However, with technological advances, thoracic endovascular repair (TEVAR) offers an alternative treatment option for BTAI. TEVAR is a less invasive surgical approach for management of these already critical patients; many reports have described favourable early outcomes.Thoracic endovascular repair may appear to be superior to open repair for treatment of BTAI. However, its long-term results and efficacy remain unknown. No randomised controlled trials (RCTs) have provided evidence to support the superiority of the endovascular approach versus open repair in the treatment of BTAI. This review aims to address this matter.
  
  
  OBJECTIVE
  To determine whether use of TEVAR for treatment of BTAI is associated with reduced mortality and morbidity when compared with conventional open surgery.
  
  
  METHODS
  The Cochrane Vascular Trials Search Co-ordinator searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2015, Issue 7) and clinical trials databases for details of ongoing and unpublished studies.
  
  
  METHODS
  We considered all published and unpublished randomised controlled trials (RCTs) comparing TEVAR and open surgery for BTAI.
  
  
  METHODS
  Two review authors independently reviewed all RCTs identified by the Trials Search Co-ordinator.
  
  
  RESULTS
  We found no RCTs that met the inclusion criteria for this review.
  
  
  CONCLUSIONS
  We found no RCTs conducted to determine whether use of TEVAR for the treatment of BTAI is associated with reduced mortality and morbidity when compared to conventional open repair. Hence, we are unable to provide any evidence to guide the treatment option for this life-threatening condition. To perform a randomised controlled trial to clarify the optimal management of BTAI would be highly challenging due to the natural history of the condition. Despite the lack of RCT evidence, clinicians are moving forward with endovascular treatment of BTAI on the basis of meta-analyses and large clinical series.
authors.affiliation: NHS Grampian, Foresterhill Road, Aberdeen, UK, AB25 2ZN.
authors.forename: Dominic
authors.initials: D
authors.lastname: Pang
authors.forename: Diane
authors.initials: D
authors.lastname: Hildebrand
authors.forename: Paul
authors.initials: P
authors.lastname: Bachoo
mesh_terms: D001013:Aorta, Thoracic / Q000293:injuries*; D057510:Endovascular Procedures / Q000379:methods* / Q000401:mortality; D006801:Humans; D014949:Wounds, Nonpenetrating / Q000401:mortality / Q000601:surgery*