title: Doege-Potter Syndrome.
abstract: Doege-Potter syndrome is a rare paraneoplastic syndrome presenting as a hypoinsulinaemic hypoglycaemia from the ectopic secretion of a prohormone of insulin-like growth factor II (IGF-II) from a solitary fibrous tumour. Surgical resection is curative in the majority of cases. If, however, the diagnosis is not suspected and treatment is delayed, it can lead to hypoxic cerebral injury or death. The underlying tumour can be a benign or malignant pleural tumour but may be present in extrapleural sites. For a diagnosis of Doege-Potter syndrome, symptoms attributable to hypoglycaemia and low blood glucose levels should be present along with the secretion of prohormone IGF-II. We report a case of severe hypoglycaemia in a 76-year-old inpatient admitted for resection of a recurrent left-sided pleural tumour. Investigation revealed true hypoglycaemia and Doege-Potter syndrome was diagnosed. The tumour was completely resected and the patient made a full recovery with no further hypoglycaemic episodes.
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust , UK.
authors.forename: N
authors.initials: N
authors.lastname: Ahluwalia
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust , UK.
authors.forename: R
authors.initials: R
authors.lastname: Attia
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust , UK.
authors.forename: A
authors.initials: A
authors.lastname: Green
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust , UK.
authors.forename: P
authors.initials: P
authors.lastname: Cane
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust , UK.
authors.forename: T
authors.initials: T
authors.lastname: Routledge
mesh_terms: D000368:Aged; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D008297:Male; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology; D054363:Solitary Fibrous Tumor, Pleural / Q000150:complications / Q000175:diagnosis*
keywords: Fibroma; Hypoglycaemia; Insulin-like growth factor II; Thoracic surgery