title: MYOPIC RETINOSCHISIS IN ASIANS: Structural Features and Determinants of Visual Acuity and Prognostic Factors for Progression.
abstract: OBJECTIVE
  To describe microstructural changes and schisis extent in eyes with myopic retinoschisis and to determine their influence on visual acuity at baseline and follow-up.
  
  
  METHODS
  In this prospective observational study, 50 eyes of 38 patients with myopic retinoschisis were evaluated using spectral domain optical coherence tomography, and the patients were followed for at least 12 months. The presence of microstructural changes and the extent of retinoschisis at baseline on spectral domain optical coherence tomography, and the association between these parameters and the risk of visual acuity deterioration were analyzed.
  
  
  RESULTS
  Median presenting visual acuity and central retinal thickness were 0.31 logMAR (≈20/40) and 395 μm, respectively. Twenty-six eyes (52%) had entire macular area retinoschisis. Common microstructural changes included photoreceptor detachment (24%), foveal ellipsoid zone (EZ) disruption (34%), partial-thickness macular hole (26%), and full-thickness macular hole (16%). Visual acuity was poorer in eyes with photoreceptor detachment, EZ disruption, full-thickness macular hole, and central retinal thickness >300 μm. Eyes with entire macular area retinoschisis had the poorest visual acuity and thickest central retinal thickness, and they were more likely to have photoreceptor detachment, EZ disruption, and retinal detachment. Over a mean follow-up of 31.7 ± 7.7 months, 14 eyes (28%) had worsening visual acuity of ≥2 lines. Ten of these 14 eyes had entire macular retinoschisis at baseline.
  
  
  CONCLUSIONS
  Most eyes with myopic retinoschisis remain stable. However, eyes with extensive retinoschisis involving the entire macular area are more likely to progress and have microstructural abnormalities and poorer vision. Early surgery should be considered for these eyes.
authors.affiliation: *Singapore National Eye Center, Department of Ophthalmology, Tan Tock Seng Hospital, Singapore, Singapore; †Singapore National Eye Centre, Singapore, Singapore; ‡Singapore Eye Research Institute, Singapore, Singapore; §Ophthalmology Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore, Singapore; and ¶Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
authors.forename: Clarissa
authors.initials: C
authors.lastname: Cheng
authors.forename: Kelvin
authors.initials: K
authors.lastname: Teo
authors.forename: Colin S
authors.initials: CS
authors.lastname: Tan
authors.forename: Shu Yen
authors.initials: SY
authors.lastname: Lee
authors.forename: Boon Kwang
authors.initials: BK
authors.lastname: Loh
authors.forename: Edmund
authors.initials: E
authors.lastname: Wong
authors.forename: Doric
authors.initials: D
authors.lastname: Wong
authors.forename: Tien Yin
authors.initials: TY
authors.lastname: Wong
authors.forename: Chui Ming Gemmy
authors.initials: CM
authors.lastname: Cheung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology; D011379:Prognosis; D011446:Prospective Studies; D012160:Retina / Q000473:pathology*; D041441:Retinoschisis / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology; D012307:Risk Factors; D012846:Singapore / Q000453:epidemiology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*