title: Non-invasive Measurement of Skin Autofluorescence as a Beneficial Surrogate Marker for Atherosclerosis in Patients with Type 2 Diabetes.
abstract: Advanced glycation end-products (AGEs) are thought to play a major role in the pathogenesis of diabetic vascular complications. Skin autofluorescence (AF) was recently reported to represent tissue AGEs accumulation with a non-invasive method. The aim of the present study was to evaluate association between AF value and diabetic vascular complications, such as retinopathy, nephropathy and cervical atherosclerosis using the carotid intima-media thickness (IMT), an established marker of cardiovascular disease in patients with type 2 diabetes. A total of 68 patients with type 2 diabetes were enrolled in a cross-sectional manner. AGEs accumulation was measured with AF reader. Clinical parameters were collected at the time of AF and IMT measurement. Max-IMT was correlated with age and AF (r=0.407, p=0.001), but not with HbA1c, GA, and pentosidine. Also, AF was not correlated with HbA1c, GA and pentosidine, but was correlated with age (r=0.560, p<0.001), duration of diabetes (r=0.256, p<0.05). Multivariate regression analysis revealed that AF, but not age, was an independent determinant of max-IMT. In conclusion, AF might be a beneficial surrogate marker for evaluating carotid atherosclerosis in patients with type 2 diabetes non-invasively. J. Med. Invest. 62: 126-129, August, 2015.
authors.affiliation: Department of Hematology, Endocrinology & Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School.
authors.forename: Jin
authors.initials: J
authors.lastname: Temma
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Toru
authors.initials: T
authors.lastname: Horie
authors.forename: Akio
authors.initials: A
authors.lastname: Kuroda
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Mori
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Tamaki
authors.forename: Itsuro
authors.initials: I
authors.lastname: Endo
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Aihara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abe
authors.forename: Toshio
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000175:diagnosis* / Q000209:etiology; D015415:Biomarkers; D002340:Carotid Artery Diseases / Q000175:diagnosis*; D059168:Carotid Intima-Media Thickness; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000175:diagnosis*; D005260:Female; D005453:Fluorescence; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced