title: Elevated Plasma Soluble ST2 Is Associated with Heart Failure Symptoms and Outcome in Aortic Stenosis.
abstract: B-type natriuretic peptide (BNP) is often used as a complementary finding in the diagnostic work-up of patients with aortic stenosis (AS). Whether soluble ST2, a new biomarker of cardiac stretch, is associated with symptomatic status and outcome in asymptomatic AS is unknown. sST2 and BNP levels were measured in 86 patients (74±13 years; 59 asymptomatic, 69%) with AS (<1.5 cm2) and preserved left ventricular ejection fraction who were followed-up for 26±16 months. Both BNP and sST2 were associated with NYHA class but sST2 (>23 ng/mL, AUC = 0.68, p<0.01) was more accurate to identify asymptomatic patients or those who developed symptoms during follow-up. sST2 was independently related to left atrial index (p<0.0001) and aortic valve area (p = 0.004; model R2 = 0.32). A modest correlation was found with BNP (r = 0.4, p<0.01). During follow-up, 29 asymptomatic patients (34%) developed heart failure symptoms. With multivariable analysis, peak aortic jet velocity (HR = 2.7, p = 0.007) and sST2 level (HR = 1.04, p = 0.03) were independent predictors of cardiovascular events. In AS, sST2 levels could provide complementary information regarding symptomatic status, new onset heart failure symptoms and outcome. It might become a promising biomarker in these patients.
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium; Gruppo Villa Maria Care and Research, Lugo (RA), Italy.
authors.forename: Patrizio
authors.initials: P
authors.lastname: Lancellotti
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Raluca
authors.initials: R
authors.lastname: Dulgheru
authors.affiliation: Department of Cardiology, CHU Dupuytren, and INSERM 1094, Faculté de Médecine de Limoges, Limoges, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Magne
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Henri
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Laurence
authors.initials: L
authors.lastname: Servais
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Nassim
authors.initials: N
authors.lastname: Bouznad
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Ancion
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Martinez
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Laurent
authors.initials: L
authors.lastname: Davin
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Le Goff
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Alain
authors.initials: A
authors.lastname: Nchimi
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Piérard
authors.affiliation: GIGA Cardiovascular Sciences, Heart Valve Clinic, Department of Cardiology and Radiology, University of Liège Hospital, and University of Liège, Liège, Belgium.
authors.forename: Cécile
authors.initials: C
authors.lastname: Oury
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000503:physiopathology*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000097:blood*
chemical_list: C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011956:Receptors, Cell Surface