title: [Bone Cell Biology Assessed by Microscopic Approach. The effects of bisphosphonates on bone remodeling, microdamage accumulation and fracture repair process].
abstract: Basically bisphosphonates are the agents that prevent the deterioration of bone structure due to suppressed bone remodeling although they are able to increase the thickness of cortical bone by suppressing bone resorption in the cortical surfaces. On the other hand, suppression of bone remodeling allows microdamage accumulation by impaired repair of damages, therefore, severe remodeling suppression over long time period could promote bone fatigue process, leading to fatigue fractures such as atypical femoral fracture. The use of bisphosphonate after fracture may delays natural fracture healing process due to suppressed callus remodeling. Bisphosphonate that has high binding affinity to bone easily accumulates in bone, therefore, easily causes severely suppressed bone turnover following long term treatment, and its effects last longer even after withdrawal.
authors.affiliation: Department of Orthopedic Surgery, Kagawa University Faculty of Medicine, Japan.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Mashiba
mesh_terms: D050071:Bone Density Conservation Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016723:Bone Remodeling / Q000187:drug effects*; D004164:Diphosphonates / Q000494:pharmacology* / Q000627:therapeutic use; D050723:Fractures, Bone / Q000188:drug therapy*; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates