title: Impact of intrauterine growth restriction on preterm lung disease.
abstract: OBJECTIVE
  Intrauterine growth restriction (IUGR) is an important cause for prematurity and adversely influences prematurity-related morbidities. This study evaluates the impact of IUGR on respiratory outcomes in infants <32 weeks with IUGR and birthweight <10th centile (SGA) compared to matched appropriate for gestation (AGA) controls.
  
  
  METHODS
  The primary outcomes of this retrospective study are short-term pulmonary outcomes of chronic lung disease (CLD), CLD or death, and need for home oxygen at discharge. Subgroup analysis by gestation-based stratification (<28 and ≥28 <32 weeks) was decided a priori.
  
  
  RESULTS
  Total of 153 IUGR and 306 non-IUGR infants were enrolled. The rate of CLD (45% vs. 17%, p = 0.0001), death (16% vs. 4.6%, p = 0.0001), CLD or death (46% vs. 21.5%, p = 0.0001), home oxygen rates (13.7% vs. 6.5%, p = 0.01) and duration of respiratory support was significantly higher in the IUGR group. IUGR emerged as the strongest predictor of CLD (adjusted OR, 95%CI: (8.4 [2, 35]) and CLD or death (12.7 [3, 54]) across all gestation.
  
  
  CONCLUSIONS
  IUGR is a major risk factor for adverse short-term pulmonary outcomes as reflected by higher rates of CLD, CLD or death, and oxygen dependency at discharge in preterm infants.
authors.affiliation: Monash Newborn, Monash Children's Hospital, Melbourne, Vic., Australia.
authors.forename: Arun
authors.initials: A
authors.lastname: Sasi
authors.affiliation: Monash Newborn, Monash Children's Hospital, Melbourne, Vic., Australia.
authors.forename: Vinita
authors.initials: V
authors.lastname: Abraham
authors.affiliation: The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Vic., Australia.
authors.forename: Miranda
authors.initials: M
authors.lastname: Davies-Tuck
authors.affiliation: The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Vic., Australia.|Department of Obstetrics and Gynaecology, Monash University, Melbourne, Vic., Australia.
authors.forename: Graeme R
authors.initials: GR
authors.lastname: Polglase
authors.affiliation: The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Vic., Australia.|Department of Obstetrics and Gynaecology, Monash University, Melbourne, Vic., Australia.
authors.forename: Graham
authors.initials: G
authors.lastname: Jenkin
authors.affiliation: The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Vic., Australia.|Department of Obstetrics and Gynaecology, Monash University, Melbourne, Vic., Australia.
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Miller
authors.affiliation: Monash Newborn, Monash Children's Hospital, Melbourne, Vic., Australia.|The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Vic., Australia.|Department of Paediatrics, Monash University, Melbourne, Vic., Australia.
authors.forename: Atul
authors.initials: A
authors.lastname: Malhotra
mesh_terms: D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D012189:Retrospective Studies
keywords: Chronic lung disease; Intrauterine growth restriction; Prematurity