title: [Pseudo-pheochromocytoma due to iproniazid: A case report].
abstract: BACKGROUND
  Pheochromocytoma is suggested by the presence of severe and paroxysmal hypertension associated with hyperadrenergy clinical signs. If the diagnosis of pheochromocytoma is ruled out, a pseudo-pheochromocytoma should be considered. We report a clinical observation of pseudo-pheochromocytoma due to iproniazid, a non-selective irreversible monoamine oxidase (MAO) A and B inhibitor in a patient with bipolar disorder.
  
  
  METHODS
  A 78-year-old Caucasian male patient treated by iproniazid was hospitalized for depressive relapse. After several episodes of syncopes related to orthostatic hypotension, the patient presented hypertensive crisis. Urinary normetanephrines were increased to twice the upper limit of the normal range. Iproniazid was discontinued. Patient hemodynamic was rapidly stabilized and sympathetic hypertonia diminished. The urinary measurements normalized within two months. The abdominal imaging eliminated an adrenal tumor.
  
  
  CONCLUSIONS
  Iproniazid could be responsible for severe irregular blood pressure associated with abnormal catecholamine metabolism (i.e. pseudo-pheochromocytoma).
authors.affiliation: Service de psychiatrie, centre Esquirol, CHU de Caen, 14000 Caen, France; CNRS, UMR 6301, imagerie et stratégies thérapeutiques des pathologies cérébrales et tumorales (ISTCT), équipe imagerie et stratégies thérapeutiques de la schizophrénie (ISTS), GIP CYCERON, boulevard Henri-Becquerel, 14074 Caen cedex, France. Electronic address: maxime.trehout@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Tréhout
authors.affiliation: Centre régional de pharmacovigilance de Caen Basse-Normandie, CHU de Caen, 14000 Caen, France; UFR de médecine, université de Caen Basse-Normandie, Caen, 14000 France.
authors.forename: S
authors.initials: S
authors.lastname: Fedrizzi
authors.affiliation: UFR de médecine, université de Caen Basse-Normandie, Caen, 14000 France; Service de médecine gériatrie aiguë, CHU de Caen, 14000 Caen, France.
authors.forename: G
authors.initials: G
authors.lastname: Loggia
authors.affiliation: Service de psychiatrie, centre Esquirol, CHU de Caen, 14000 Caen, France; CNRS, UMR 6301, imagerie et stratégies thérapeutiques des pathologies cérébrales et tumorales (ISTCT), équipe imagerie et stratégies thérapeutiques de la schizophrénie (ISTS), GIP CYCERON, boulevard Henri-Becquerel, 14074 Caen cedex, France; UFR de médecine, université de Caen Basse-Normandie, Caen, 14000 France.
authors.forename: L
authors.initials: L
authors.lastname: Lecardeur
authors.affiliation: Service de psychiatrie, centre Esquirol, CHU de Caen, 14000 Caen, France; CNRS, UMR 6301, imagerie et stratégies thérapeutiques des pathologies cérébrales et tumorales (ISTCT), équipe imagerie et stratégies thérapeutiques de la schizophrénie (ISTS), GIP CYCERON, boulevard Henri-Becquerel, 14074 Caen cedex, France; UFR de médecine, université de Caen Basse-Normandie, Caen, 14000 France.
authors.forename: C
authors.initials: C
authors.lastname: Nathou
authors.affiliation: Service de psychiatrie, centre Esquirol, CHU de Caen, 14000 Caen, France; CNRS, UMR 6301, imagerie et stratégies thérapeutiques des pathologies cérébrales et tumorales (ISTCT), équipe imagerie et stratégies thérapeutiques de la schizophrénie (ISTS), GIP CYCERON, boulevard Henri-Becquerel, 14074 Caen cedex, France; UFR de médecine, université de Caen Basse-Normandie, Caen, 14000 France.
authors.forename: S
authors.initials: S
authors.lastname: Dollfus
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000139:chemically induced*; D000368:Aged; D006801:Humans; D007490:Iproniazid / Q000009:adverse effects*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects*; D010673:Pheochromocytoma / Q000139:chemically induced*
chemical_list: D008996:Monoamine Oxidase Inhibitors; D007490:Iproniazid
keywords: Hypertension artérielle sévère; Iproniazid; Iproniazide; Pseudo-pheochromocytoma; Pseudo-phéochromocytome; Severe hypertension