title: Autophagy signal transduction by ATG proteins: from hierarchies to networks.
abstract: Autophagy represents an intracellular degradation process which is involved in both cellular homeostasis and disease settings. In the last two decades, the molecular machinery governing this process has been characterized in detail. To date, several key factors regulating this intracellular degradation process have been identified. The so-called autophagy-related (ATG) genes and proteins are central to this process. However, several additional molecules contribute to the outcome of an autophagic response. Several review articles describing the molecular process of autophagy have been published in the recent past. In this review article we would like to add the most recent findings to this knowledge, and to give an overview of the network character of the autophagy signaling machinery.
authors.affiliation: Institute of Molecular Medicine I, Heinrich-Heine-University, Universitätsstr. 1, Building 23.12, 40225, Düsseldorf, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wesselborg
authors.affiliation: Institute of Molecular Medicine I, Heinrich-Heine-University, Universitätsstr. 1, Building 23.12, 40225, Düsseldorf, Germany. bjoern.stork@uni-duesseldorf.de.
authors.forename: Björn
authors.initials: B
authors.lastname: Stork
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010588:Phagosomes; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D051381:Rats; D015398:Signal Transduction
chemical_list: D011494:Protein Kinases
keywords: ATG; Autophagy; LC3; PtdIns3K; ULK