title: Short-term effects of T-2 toxin exposure on some lipid peroxide and glutathione redox parameters of broiler chickens.
abstract: The purpose of this study was to investigate the short-term effects of T-2 toxin exposure (3.09 mg/kg feed) on lipid peroxidation and glutathione redox system of broiler chicken. A total of 54 Cobb 500 cockerels were randomly distributed to two experimental groups at 21 days of age. Samples (blood plasma, red blood cell, liver, kidney and spleen) were collected every 12 h during a 48-h period. The results showed that the initial phase of lipid peroxidation, as measured by conjugated dienes and trienes in the liver, was continuously, but not significantly higher in T-2 toxin-dosed birds than in control birds. The termination phase of lipid peroxidation, as measured by malondialdehyde, was significantly higher in liver and kidney as a result of T-2 toxin exposure at the end of the experimental period (48th hour). The glutathione redox system activated shortly after starting the T-2 toxin exposure, which is supported by the significantly higher concentration of reduced glutathione and glutathione peroxidase activity in blood plasma at 24 and 48 h, in liver at 12, 24 and 36 h, and in kidney and spleen at 24 h. These results suggest that T-2 toxin, or its metabolites, may be involved in the generation of reactive oxygen substances which causes an increase in lipid peroxidation, and consequently activates the glutathione redox system, namely synthesis of reduced glutathione and glutathione peroxidase.
authors.affiliation: Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Bócsai
authors.affiliation: Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.
authors.forename: Cs
authors.initials: C
authors.lastname: Pelyhe
authors.affiliation: 'MTA-KE Mycotoxins in the Food Chain' Research Group, Hungarian Academy of Sciences, Kaposvár University, Kaposvár, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Zándoki
authors.affiliation: Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.
authors.forename: Zs
authors.initials: Z
authors.lastname: Ancsin
authors.affiliation: 'MTA-KE Mycotoxins in the Food Chain' Research Group, Hungarian Academy of Sciences, Kaposvár University, Kaposvár, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Szabó-Fodor
authors.affiliation: Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Erdélyi
authors.affiliation: Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Mézes
authors.affiliation: Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.
authors.forename: K
authors.initials: K
authors.lastname: Balogh
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002645:Chickens / Q000097:blood / Q000378:metabolism*; D004334:Drug Administration Schedule; D005978:Glutathione / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D010084:Oxidation-Reduction; D013154:Spleen / Q000187:drug effects; D013605:T-2 Toxin / Q000008:administration & dosage / Q000633:toxicity*; D014280:Triglycerides
chemical_list: D014280:Triglycerides; D008315:Malondialdehyde; D005978:Glutathione; D013605:T-2 Toxin
keywords: T-2 toxin; chicken; glutathione; glutathione peroxidase; malondialdehyde