title: Extraction Socket Management Utilizing Platelet Rich Fibrin: A Proof-of-Principle Study of the "Accelerated-Early Implant Placement" Concept.
abstract: Dental implants are widely accepted as the golden standard for the rehabilitation of an edentulous site following the extraction of a tooth. The ideal time for implant placement is dependent on the time required for partial or complete tissue healing and the adequacy of socket dimensions. The use of autologous growth factors is a promising new concept that aids clinicians in minimizing treatment time and increasing patient satisfaction. The purpose of this paper is to introduce a protocol for "accelerated-early" implant placement. In this protocol, platelet rich fibrin is employed to accelerate soft and hard tissue healing and to provide a better-healed recipient site for accelerated, early implant placement. Histological analysis revealed that at 6 weeks postextraction, the application of our approach resulted in delicate newly formed bone showing intense osteoblastic activity surrounded by connective tissue as well as areas of mineralized tissue. The present study is a proof-of-principle study of the acceleration of the physiologic postextraction healing sequelae with the use of autologous growth factors. The accelerated-early implant placement concept is a bioengineered protocol that may aid clinicians to achieve increased primary stability, by placing implants in ridges in an advanced stage of bone healing, while offering patients the benefits associated with early implant placement. Controlled studies are warranted to verify the reproducibility of this treatment concept and identify specific indications where the use of the presented technique can lead to significant clinical results.
authors.affiliation: 1   Department of Periodontics, University of Washington, Seattle, Wash.
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Kotsakis
authors.affiliation: 2   University of Athens Medical School, Athens, Greece.
authors.forename: Foteini
authors.initials: F
authors.lastname: Boufidou
authors.affiliation: 1   Department of Periodontics, University of Washington, Seattle, Wash.
authors.forename: James E
authors.initials: JE
authors.lastname: Hinrichs
authors.affiliation: 3   Hard Tissue Research Laboratory, University of Minnesota, Minneapolis, Minn.
authors.forename: Hari S
authors.initials: HS
authors.lastname: Prasad
authors.affiliation: 3   Hard Tissue Research Laboratory, University of Minnesota, Minneapolis, Minn.
authors.forename: Michael
authors.initials: M
authors.lastname: Rohrer
authors.affiliation: 4   Department of Oral Pathology, Dental School, University of Athens, Athens, Greece.
authors.forename: Kostantinos I
authors.initials: KI
authors.lastname: Tosios
mesh_terms: D003758:Dental Implantation, Endosseous; D006801:Humans; D017060:Patient Satisfaction; D000073183:Platelet-Rich Fibrin; D015203:Reproducibility of Results; D014081:Tooth Extraction; D020390:Tooth Socket; D016896:Treatment Outcome
keywords: PRF; early implant placement; extraction; platelet rich fibrin; socket preservation