title: The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes.
abstract: The prediction of the quaternary structure of biomolecular macromolecules is of paramount importance for fundamental understanding of cellular processes and drug design. In the era of integrative structural biology, one way of increasing the accuracy of modeling methods used to predict the structure of biomolecular complexes is to include as much experimental or predictive information as possible in the process. This has been at the core of our information-driven docking approach HADDOCK. We present here the updated version 2.2 of the HADDOCK portal, which offers new features such as support for mixed molecule types, additional experimental restraints and improved protocols, all of this in a user-friendly interface. With well over 6000 registered users and 108,000 jobs served, an increasing fraction of which on grid resources, we hope that this timely upgrade will help the community to solve important biological questions and further advance the field. The HADDOCK2.2 Web server is freely accessible to non-profit users at http://haddock.science.uu.nl/services/HADDOCK2.2.
authors.affiliation: Bijvoet Center for Biomolecular Research, Faculty of Science Department of Chemistry, Utrecht University, Domplein 29, 3512 JE Utrecht, the Netherlands.
authors.forename: G C P
authors.initials: GCP
authors.lastname: van Zundert
authors.affiliation: Bijvoet Center for Biomolecular Research, Faculty of Science Department of Chemistry, Utrecht University, Domplein 29, 3512 JE Utrecht, the Netherlands.
authors.forename: J P G L M
authors.initials: JPGLM
authors.lastname: Rodrigues
authors.affiliation: Centre National de la Recherche Scientifique Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur, rue John Von Neumann, 91403 Orsay, France.
authors.forename: M
authors.initials: M
authors.lastname: Trellet
authors.affiliation: Instaclustr Level 5, 1 Moore Street, Canberra ACT 2600, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Schmitz
authors.affiliation: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: P L
authors.initials: PL
authors.lastname: Kastritis
authors.affiliation: European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Karaca
authors.affiliation: Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
authors.forename: A S J
authors.initials: ASJ
authors.lastname: Melquiond
authors.affiliation: Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, the Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: van Dijk
authors.affiliation: Physik-Department, Technische Universität München, James-Franck-Strasse 1, 85748 Garching, Germany.
authors.forename: S J
authors.initials: SJ
authors.lastname: de Vries
authors.affiliation: Bijvoet Center for Biomolecular Research, Faculty of Science Department of Chemistry, Utrecht University, Domplein 29, 3512 JE Utrecht, the Netherlands.
authors.forename: A M J J
authors.initials: AMJJ
authors.lastname: Bonvin
mesh_terms: D019295:Computational Biology / Q000379:methods*; D020407:Internet; D046911:Macromolecular Substances / Q000737:chemistry*; D008967:Molecular Biology / Q000379:methods*
chemical_list: D046911:Macromolecular Substances
keywords: biomolecular docking; data-driven; grid computing; hybrid modeling; protein complexes