title: Effect of Chronic Administration of Estradiol on Responsiveness of Isolated Systemic and Pulmonary Blood Vessels from Ovariectomized Wistar Rats with Hypoxic Pulmonary Hypertension.
abstract: The long-term (4 weeks) administration of estradiol (15 μg/kg/day) to ovariectomized female Wistar rats induced hypoxic pulmonary hypertension and significantly (p<0.05) diminished relaxation of perfused serotonin-preconstricted isolated vascular segments of the pulmonary artery in response to estradiol (10(-6) M). At the same time, the isolated segments of systemic popliteal artery demonstrated a diminished response to serotonin and increased relaxation induced by acetylcholine (10(-5) M) or estradiol (10(-5) M) in comparison with preconstricted control vessels. Moderation of responsiveness to estradiol in pulmonary circulation can be one of the factors underlying the pro-hypertensive action of estradiol in female rats with hypoxic pulmonary hypertension.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia. marinka.artemieva@gmail.com.
authors.forename: M M
authors.initials: MM
authors.lastname: Artem'eva
authors.affiliation: Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Yu O
authors.initials: YO
authors.lastname: Kovaleva
authors.affiliation: Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Medvedev
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Medvedeva
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D011150:Popliteal Artery / Q000187:drug effects / Q000503:physiopathology; D065840:Protective Factors; D011651:Pulmonary Artery / Q000187:drug effects / Q000503:physiopathology*; D017208:Rats, Wistar; D014664:Vasodilation; D014665:Vasodilator Agents / Q000494:pharmacology; D017725:Ventricular Pressure
chemical_list: D014665:Vasodilator Agents; D004958:Estradiol; D000109:Acetylcholine
keywords: 17β-estradiol; acetylcholine; female rats; hypoxic pulmonary hypertension; isolated arteries