title: Improvement of bioactivity, degradability, and cytocompatibility of biocement by addition of mesoporous magnesium silicate into sodium-magnesium phosphate cement.
abstract: A novel mesoporous magnesium-based cement (MBC) was fabricated by using the mixed powders of magnesium oxide, sodium dihydrogen phosphate, and mesoporous magnesium silicate (m-MS). The results indicate that the setting time and water absorption of the MBC increased as a function of increasing m-MS content, while compressive strength decreased. In addition, the degradability of the MBC in a solution of Tris-HCl and the ability of apatite formation on the MBC were significantly improved with the increase in m-MS content. In cell culture experiments, the results show that the attachment, proliferation, and alkaline phosphatase activity of the MC3T3-E1 cells on the MBC were significantly enhanced with the increase of the content of m-MS. It can be suggested that the MBC with good cytocompatibility could promote the proliferation and differentiation of the MC3T3-E1 cells. In short, our findings indicate that the MBC containing m-MS had promising potential as a new biocement for bone regeneration and repair applications.
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. 13262918095@163.com.
authors.forename: Yingyang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Tang
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, People's Republic of China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Tang
authors.affiliation: Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, People's Republic of China.
authors.forename: Han
authors.initials: H
authors.lastname: Guo
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
authors.forename: Songchao
authors.initials: S
authors.lastname: Tang
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
authors.forename: Liming
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Polymer Science (Shenzhen) New Materials Co., Ltd., Shenzhen, 518101, People's Republic of China.
authors.forename: Xuhui
authors.initials: X
authors.lastname: Ma
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. biomaterbone@163.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Hong
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. jiewei7860@sina.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
mesh_terms: D016475:3T3 Cells; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001672:Biocompatible Materials; D049109:Cell Proliferation; D017616:Magnesium Compounds / Q000737:chemistry*; D017633:Magnesium Silicates / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014014:Tissue Adhesives; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D017616:Magnesium Compounds; D017633:Magnesium Silicates; D010710:Phosphates; D014014:Tissue Adhesives; C005013:Florisil; C030781:magnesium phosphate; D000469:Alkaline Phosphatase