title: Renal Replacement Therapy.
abstract: Renal replacement therapy (RRT) is a cornerstone in the clinical management of patients with acute kidney injury. Results from different studies agree that early renal support therapy (aimed to support the residual kidney function during early phases of organ dysfunction) may reduce mortality with respect to late RRT (aimed to substitute the complete loss of function during the advanced kidney insufficiency). Although it seems plausible that a timely initiation of RRT may be associated with improved renal and nonrenal outcomes in these patients, there is scarce evidence in literature to exactly identify the most adequate onset timing for RRT.
authors.affiliation: Section of Anaesthesiology and Intensive Care, Department of Health Science, University of Florence, Florence, Italy. Electronic address: gianlucavilla1@gmail.com.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Villa
authors.affiliation: Pediatric Cardiac Intensive Care Unit, Department of Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, CAP 00165, Rome, Italy.
authors.forename: Zaccaria
authors.initials: Z
authors.lastname: Ricci
authors.affiliation: Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Viale Ferdinando Rodolfi 37, CAP 36100, Vicenza, Italy; International Renal Research Institute, San Bortolo Hospital, Vicenza, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology / Q000628:therapy*; D000925:Anticoagulants / Q000008:administration & dosage; D006801:Humans; D006435:Renal Dialysis / Q000379:methods; D017582:Renal Replacement Therapy / Q000379:methods*; D013997:Time Factors; D062666:Vascular Access Devices
chemical_list: D000925:Anticoagulants
keywords: Citrate; Continuous renal replacement therapy; Dose; Heparin; Timing