title: Interleukin-10 Production in Response to Amyloid-β Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease.
abstract: We investigated IL-10 and IL-6 production in amyloid-β (Aβ) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer's disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position -592, -819, -1082), IL-6 (-174), transforming growth factor-β1 (TGF-β1) (-10, -25), interferon-γ (IFN-γ) (-874), and tumor necrosis factor-α (TNF-α) (-308) genes were analyzed. IL-10 production after Aβ stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners. Association between AA IFN-γ low-producing genotype and fast progression was demonstrated. Investigations in a larger sample will clarify these findings.
authors.affiliation: ImmunoClin Ltd, London, UK.|UPMC University Paris 06, UMR 8256 Biological Adaptation and Ageing (B2A) Team Brain Development, Repair and Aging (BDRA), Paris, France.|CNRS, UMR 8256 Biological Adaptation and Ageing (B2A) Team Brain Development, Repair and Aging (BDRA), Paris, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Asselineau
authors.affiliation: ImmunoClin Ltd, London, UK.
authors.forename: Khadija
authors.initials: K
authors.lastname: Benlhassan
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.|Geriatric Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Arosio
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.|Geriatric Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Mari
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Ferri
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Casati
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gussago
authors.affiliation: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Tedone
authors.affiliation: Geriatric Clinic, Department of Health Science, Milan Center for Neuroscience, University Study of Milano-Bicocca, Milan, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Annoni
authors.affiliation: Geriatric Clinic, Department of Health Science, Milan Center for Neuroscience, University Study of Milano-Bicocca, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Mazzola
authors.affiliation: AP-HP, DHU FAST GH Pitie-Salpêtrière-Charles Foix, Paris, France.
authors.forename: Francois
authors.initials: F
authors.lastname: Piette
authors.affiliation: AP-HP, DHU FAST GH Pitie-Salpêtrière-Charles Foix, Paris, France.
authors.forename: Joel
authors.initials: J
authors.lastname: Belmin
authors.affiliation: AP-HP, DHU FAST GH Pitie-Salpêtrière-Charles Foix, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Pariel
authors.affiliation: AP-HP, DHU FAST GH Pitie-Salpêtrière-Charles Foix, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Bornand
authors.affiliation: UMR-S 1139 "Pathophysiology and pharmacotoxicology of human placenta", Faculty of Pharmacy, Paris Descartes, Paris, France.|Department of Medical Biochemistry, Necker Hospital, AP-HP, Paris, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Beaudeux
authors.affiliation: UPMC University Paris 06, UMR 8256 Biological Adaptation and Ageing (B2A) Team Brain Development, Repair and Aging (BDRA), Paris, France.|CNRS, UMR 8256 Biological Adaptation and Ageing (B2A) Team Brain Development, Repair and Aging (BDRA), Paris, France.|AP-HP, DHU FAST GH Pitie-Salpêtrière-Charles Foix, Paris, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Doulazmi
authors.affiliation: UPMC University Paris 06, UMR 8256 Biological Adaptation and Ageing (B2A) Team Brain Development, Repair and Aging (BDRA), Paris, France.|CNRS, UMR 8256 Biological Adaptation and Ageing (B2A) Team Brain Development, Repair and Aging (BDRA), Paris, France.|AP-HP, DHU FAST GH Pitie-Salpêtrière-Charles Foix, Paris, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Mariani
authors.affiliation: ImmunoClin Ltd, London, UK.
authors.forename: Dorothy H
authors.initials: DH
authors.lastname: Bray
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005838:Genotype; D006801:Humans; D016898:Interferon-alpha / Q000235:genetics; D016753:Interleukin-10 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects*; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D016229:Amyloid beta-Peptides; D016898:Interferon-alpha; D015850:Interleukin-6; D016753:Interleukin-10
keywords: Alzheimer’s disease; IFN-γ; disease progression; interleukin-10; interleukin-6; peripheral blood mononuclear cells; single nucleotide polymorphisms