title: Diarrhea, bacteremia and multiorgan dysfunction due to an extraintestinal pathogenic Escherichia coli strain with enteropathogenic E. coli genes.
abstract: A 55-year-old man with well-controlled HIV had severe diarrhea for 3 weeks and developed multiorgan dysfunction and bacteremia due to Escherichia coli. The genome of the patient's isolate had features characteristic of extraintestinal pathogenic E. coli and genes distantly related to those defining enteropathogenic E. coli.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Kessler
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors.forename: Shahista
authors.initials: S
authors.lastname: Nisa
authors.affiliation: The Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors.forename: Tracy H
authors.initials: TH
authors.lastname: Hazen
authors.affiliation: Pathology and Laboratory Service, University of Maryland School of Medicine, VA Maryland Health Care System, Baltimore, MD 21201, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Horneman
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Amoroso
authors.affiliation: The Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Rasko
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA mdonnenb@umaryland.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Donnenberg
mesh_terms: D016470:Bacteremia / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D003967:Diarrhea / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D054308:Enteropathogenic Escherichia coli / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000473:pathology; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009102:Multiple Organ Failure / Q000382:microbiology* / Q000473:pathology; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial
keywords: case report; comparative genomics; hemolysin; type 3 secretion; virulence factors