title: Unified Approach to Prenylated Indole Alkaloids: Total Syntheses of (-)-17-Hydroxy-Citrinalin B, (+)-Stephacidin A, and (+)-Notoamide I.
abstract: A unified strategy for the synthesis of congeners of the prenylated indole alkaloids is presented. This strategy has yielded the first synthesis of the natural product (-)-17-hydroxy-citrinalin B as well as syntheses of (+)-stephacidin A and (+)-notoamide I. An enolate addition to anin situgenerated isocyanate was utilized in forging a key bicyclo[2.2.2]diazaoctane moiety, and in this way connected the two structural classes of the prenylated indole alkaloids through synthesis.
authors.affiliation: Department of Chemistry University of California-Berkeley Berkeley, CA 94720, USA.
authors.forename: Eduardo V
authors.initials: EV
authors.lastname: Mercado-Marin
authors.affiliation: Department of Chemistry University of California-Berkeley Berkeley, CA 94720, USA.
authors.forename: Richmond
authors.initials: R
authors.lastname: Sarpong