title: Transient azoospermia following rosuvastatin medication for hypercholesterolemia.
abstract: The authors report a case of transient azoospermia following hydroxymethylglutaryl-coenzyme A reductase (HMGCR) inhibitor rosuvastatin medication for hypercholesterolemia. While a primary infertile couple with oligoasthenospermia was preparing for an in vitro fertilization program, the male partner had been diagnosed with hypercholesterolemia in a medical check-up and prescribed four-week oral administration of rosuvastatin. No motile spermatozoa were found in the ejaculated semen and urine on the day of follicular aspiration. Azoospermia was confirmed by reexamination in weeks 3 and 7. Spermatozoa appeared in the ejaculated semen in two weeks of drug withdrawal. In week 16, the sperm count and motility increased to the level where intracytoplasmic sperm injection was available.
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Iwaki
authors.forename: M
authors.initials: M
authors.lastname: Karita
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: M
authors.initials: M
authors.lastname: Funabiki
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000284:Administration, Oral; D000328:Adult; D053713:Azoospermia / Q000139:chemically induced / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005464:Fluorobenzenes / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D007246:Infertility; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D054315:Oocyte Retrieval; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*; D013737:Testis / Q000473:pathology
chemical_list: D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium