title: Effect of treatment of a previous ectopic pregnancy on in vitro fertilization-intracytoplasmic sperm injection outcomes: a retrospective cohort study.
abstract: OBJECTIVE
  To evaluate the influence of previous ectopic pregnancies (EP) and different EP treatment methods on in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) outcomes.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-based reproductive medicine center.
  
  
  METHODS
  Women undergoing 51,268 fresh cycles of IVF-ICSI.
  
  
  METHODS
  In women who had had an EP before the IVF treatment and women who were diagnosed with fallopian disease without an EP (control group), division into three treatment subgroups: subgroup 1, conservative treatment; subgroup 2, salpingostomy; and subgroup 3 salpingectomy.
  
  
  METHODS
  Estimates of IVF-ICSI outcome and ovarian function based on number of antral follicles and rates of implantation, EP, clinical pregnancy, and delivery.
  
  
  RESULTS
  For the experimental group and the control group, there were no statistically significant differences in the rates of implantation, clinical pregnancy, or delivery. However, the risk of recurrent EP was statistically significantly higher in the experimental group compared with the control group. There were no statistically significant differences in IVF-ICSI outcomes between the three treatment subgroups in terms of the basic antral follicle number or the dominant antral follicle numbers (>1.0 cm) after surgical treatment of EP.
  
  
  CONCLUSIONS
  Our results suggest that women with a prior history of EP have a higher recurrence risk of EP after IVF in comparison with women with no history of EP. Previous EP has no effect on the main IVF-ICSI outcomes. For the treatment of EP, salpingostomy and salpingectomy do not statistically significantly affect ovarian function.
authors.affiliation: Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yan
authors.affiliation: Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.affiliation: Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.affiliation: Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Ding
authors.affiliation: Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China. Electronic address: chenzijiang@hotmail.com.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Ma
authors.affiliation: Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D008297:Male; D010053:Ovary / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011271:Pregnancy, Ectopic / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D058994:Salpingectomy; D012489:Salpingostomy; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects; D016896:Treatment Outcome
keywords: Cohort study; ectopic pregnancy; in vitro fertilization; laparoscopy