title: Complete response of adult-onset CNS Langerhans cell histiocytosis documented on 18F-FDG PET/CT.
abstract: We report a case of a 49-year-old woman with biopsy-proven multisystemic Langerhans cell histiocytosis (LCH) with hypothalamic involvement documented on F-FDG PET/CT. Chemotherapy with a combination of vinblastine, prednisolone, methotrexate, and 6-mercaptopurine was carried out. Two months later, a 90% reduction of the hypothalamic tumor mass was noted on magnetic resonance imaging, but with no signs of pathological F-FDG accumulation. The patient died 4 months later, and we found no signs of LCH on autopsy. Our case highlights the need for further studies regarding the role of F-FDG PET/CT in the assessment of treatment response in patients with LCH.
authors.affiliation: From the *Department of Endocrinology, Diabetes and Metabolic Diseases "Mladen Sekso", University Hospital Center "Sestre Milosrdnice", University of Zagreb Medical School, Zagreb, Croatia; †Department of Nuclear Medicine, Medikol Clinic, Zagreb, Croatia; ‡Division of Pediatrics, Takasago-seibu Hospital, Takasago, Japan; and §Department of Hematology, University Hospital Center "Sestre Milosrdnice", Zagreb, Croatia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Kruljac
authors.forename: Antonija
authors.initials: A
authors.lastname: Balenović
authors.forename: Petar
authors.initials: P
authors.lastname: Gaćina
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Imashuku
authors.forename: Milan
authors.initials: M
authors.lastname: Vrkljan
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007031:Hypothalamus / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18