title: Noninvasive Ventilation for Preterm Twin Neonates with Respiratory Distress Syndrome: A Randomized Controlled Trial.
abstract: Noninvasive ventilation has been proven to be effective strategies for reducing the need for endotracheal ventilation in preterm infant with respiratory distress syndrome (RDS), however the best option needs to be further determined. A single center, paired design, randomized, controlled trial was conducted between Jan 2011 and July 2014. Preterm twins with RDS were included. One of a pair was randomized to NIPPV, while another to NCPAP. Surfactant was administrated as rescue treatment. The primary outcome was the need for endotracheal ventilation. The secondary outcomes were the complications. 143 pairs were randomized and 129 pairs finished the trial. The rates of endotracheal ventilation did not differ significantly between NIPPV and NCPAP groups (11.9% vs 19.6%, P = 0.080). This difference was not observed in the subgroup of infants who received surfactant therapy (11.1% vs 19.7%, P = 0.087). No secondary outcomes also differed significantly between the two groups. NIPPV did not result in a significantly lower incidence of intubation as compared with NCPAP in preterm twins with RDS.
authors.affiliation: Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China.
authors.forename: Long
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400014, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shi
mesh_terms: D001034:Apgar Score; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D063087:Noninvasive Ventilation / Q000379:methods; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome