title: Hormonal and developmental influences on adolescent suicide: a systematic review.
abstract: BACKGROUND
  Teen suicide is a major public health problem. In the United States, it is the third cause of death among the 10-24 year olds. Adolescence involves numerous changes, whether physical, social, emotional or hormonal. At a neurobiological level, a teenager's nervous system is also affected and undergoes significant modifications.
  
  
  METHODS
  We conducted a systematic review of electronic literature published between January 1990 and August 2014 via MEDLINE, PubMED and PsychINFO to list articles concerning the risk of teen depression and suicide risks in adolescents as well as those relating to the adolescent's neuro-anatomical brain and the effect that puberty has on it.
  
  
  CONCLUSIONS
  When analyzing the various studies, it is clear that all support the idea that adolescence is a special period, both at neuroanatomical and biological levels. The risk of impulsiveness and depression is explained, anatomically, by a faster maturation of the limbic system, and biologically, by a higher sensitivity of the serotoninergic system and to glucocorticoids, which themselves are influenced by the specific hormonal environment during this period. Moreover and above all, adolescence is a vulnerable time for many reasons: physical, hormonal, social, cognitive, and emotional changes, self-development, etc. We should not restrict it to structural neurological changes without taking into account the other factors or compartmentalize young people into a reductive model based on determinism.
  
  
  CONCLUSIONS
  Adolescence is a time of change, transformation, and adaptation. The hormonal events that occur during this period have significant effects on brain development, neuro-cerebral chemistry, adolescent behavior and risks of depression. It is important to try to prevent suicide and depression in adolescents considering its entirety and complexity but also by paying attention to neuro-biological factors even if, at present, many research projects are currently underway to develop an appropriate drug therapy strategy.
authors.affiliation: Université Catholique de Louvain, Psychopathology and Psychosomatic Unit, Mont-Godinne University Hospital, 5530 Yvoir, Belgium, pmanceaux@hotmail.fr.
authors.forename: Pauline
authors.initials: P
authors.lastname: Manceaux
authors.forename: Denis
authors.initials: D
authors.lastname: Jacques
authors.forename: Nicolas
authors.initials: N
authors.lastname: Zdanowicz
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011606:Psychosexual Development / Q000502:physiology*; D011627:Puberty / Q000502:physiology; D013405:Suicide / Q000523:psychology*; D000092864:Suicide Prevention
chemical_list: D012739:Gonadal Steroid Hormones; D006854:Hydrocortisone