title: A fermented barley and soybean formula enhances skin hydration.
abstract: Skin hydration is one of the primary aims of beauty and anti-aging treatments. Barley (Hordeum vulgare) and soybean (Glycine max) are major food crops, but can also be used as ingredients for the maintenance of skin health. We developed a natural product-based skin treatment using a barley and soybean formula (BS) incorporating yeast fermentation, and evaluated its skin hydration effects as a dietary supplement in a clinical study. Participants ingested a placebo- (n = 33) or BS- (3 g/day) containing drink (n = 32) for 8 weeks. A significant increase in hydration in the BS group as compared to the placebo group was observed on the faces of subjects after 4 and 8 weeks, and on the forearm after 4 weeks. Decreases in stratum corneum (SC) thickness were also observed on the face and forearm. BS enhanced hyaluronan (HA) and skin barrier function in vitro and reduced Hyal2 expression in human dermal fibroblasts (HDF). BS also recovered ultraviolet (UV) B-induced downregulation of HA in HaCaT cells. These results suggest that BS has promising potential for development as a health functional food to enhance skin health.
authors.affiliation: WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea ; Advanced Institutes of Convergence Technology, Seoul National University, Seoul 151-921, Korea.
authors.forename: Sein
authors.initials: S
authors.lastname: Lee
authors.affiliation: WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea ; Advanced Institutes of Convergence Technology, Seoul National University, Seoul 151-921, Korea.
authors.forename: Jong-Eun
authors.initials: JE
authors.lastname: Kim
authors.affiliation: Interdisciplinary Program in Agricultural Biotechnology Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.
authors.forename: Sujin
authors.initials: S
authors.lastname: Suk
authors.affiliation: Graduate School of East-West Medical Science, Kyung Hee University, Global Campus, #1732 Deogyeong-daero, Giheung-gu, Yongin, Gyeonggi-do, 446-701, Korea.
authors.forename: Oh Wook
authors.initials: OW
authors.lastname: Kwon
authors.affiliation: WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea ; Advanced Institutes of Convergence Technology, Seoul National University, Seoul 151-921, Korea.
authors.forename: Gaeun
authors.initials: G
authors.lastname: Park
authors.affiliation: WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea ; Advanced Institutes of Convergence Technology, Seoul National University, Seoul 151-921, Korea.
authors.forename: Tae-Gyu
authors.initials: TG
authors.lastname: Lim
authors.affiliation: WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea ; Advanced Institutes of Convergence Technology, Seoul National University, Seoul 151-921, Korea.
authors.forename: Sang Gwon
authors.initials: SG
authors.lastname: Seo
authors.affiliation: WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea ; Advanced Institutes of Convergence Technology, Seoul National University, Seoul 151-921, Korea.
authors.forename: Jong Rhan
authors.initials: JR
authors.lastname: Kim
authors.affiliation: Sempio Fermentation Research Center; #183 Osongsaengmyeong 4-ro, Osongeup, Cheongwongun, Chungcheongbukdo, 363-954, Korea.
authors.forename: Dae Eung
authors.initials: DE
authors.lastname: Kim
authors.affiliation: Skin Biotechnology Center, Gyeonggi Biocenter, Suwon, Korea.
authors.forename: Miyeong
authors.initials: M
authors.lastname: Lee
authors.affiliation: Skin Biotechnology Center, Gyeonggi Biocenter, Suwon, Korea ; Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Korea.
authors.forename: Dae Kyun
authors.initials: DK
authors.lastname: Chung
authors.affiliation: Sempio Fermentation Research Center; #183 Osongsaengmyeong 4-ro, Osongeup, Cheongwongun, Chungcheongbukdo, 363-954, Korea.
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Jeon
authors.affiliation: Sempio Fermentation Research Center; #183 Osongsaengmyeong 4-ro, Osongeup, Cheongwongun, Chungcheongbukdo, 363-954, Korea.
authors.forename: Dong Woon
authors.initials: DW
authors.lastname: Cho
authors.affiliation: Sempio Fermentation Research Center; #183 Osongsaengmyeong 4-ro, Osongeup, Cheongwongun, Chungcheongbukdo, 363-954, Korea.
authors.forename: Byung Serk
authors.initials: BS
authors.lastname: Hurh
authors.affiliation: College of Pharmacy, Gachon University, #191 Hambakmoero, Yeonsu-gu, Incheon 406-799, Korea.
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.affiliation: WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea ; Advanced Institutes of Convergence Technology, Seoul National University, Seoul 151-921, Korea ; Institute on Aging, Seoul National University, Seoul 151-921, Korea.
authors.forename: Ki Won
authors.initials: KW
authors.lastname: Lee
keywords: barley; hyaluronan; skin hydration; soybean; ultraviolet B