title: Measurement of Postmortem 1,5-anhydroglucitol in Vitreous Humor for Forensic Diagnosis.
abstract: In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5-anhydroglucitol (1,5-AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5-AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5-AG concentrations in vitreous humor (mean±SD: 20.2 ± 8.7 μg/mL) and CSF (16.8 ± 8.7 μg/mL) did not differ significantly and showed a strong correlation (r(2) = 0.87, p < 0.01). These results suggest that the vitreous humor 1,5-AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5-AG concentration.
authors.affiliation: Department of Medical Technology, Faculty of Health Science, Ehime Prefectural University of Health Sciences, Ehime, Japan.|Department of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Takata
authors.affiliation: Department of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Yamasaki
authors.affiliation: Department of Medical Technology, Faculty of Health Science, Ehime Prefectural University of Health Sciences, Ehime, Japan.|Department of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitao
authors.affiliation: Department of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyaishi
mesh_terms: D001344:Autopsy; D001786:Blood Glucose; D003847:Deoxyglucose / Q000032:analysis*; D006801:Humans; D011180:Postmortem Changes; D014822:Vitreous Body / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose
keywords: 1,5-anhydroglucitol; cerebrospinal fluid; diabetes mellitus; forensic science; postmortem chemistry; vitreous humor