title: Evaluation of CYP17A1 and LEP Gene Polymorphisms in Breast Cancer.
abstract: BACKGROUND
  Polymorphisms of estrogen synthesis- and adiposity-related genes can contribute to the development of breast cancer. The purpose of the current study was to analyze the association between CYP17A1 T27C (rs743572) and LEP -2548G>A (rs7799039) gene polymorphisms and breast cancer.
  
  
  METHODS
  199 breast cancer patients and 197 healthy controls were included in the study. The CYP17A1 and LEP gene polymorphisms were determined using polymerase chain reaction-based restriction fragment length polymorphism analysis.
  
  
  RESULTS
  No statistically significant association was found between these polymorphisms and breast cancer risk among a Turkish population. However, stratified analysis of these polymorphisms in relation to different clinicopathological characteristics of breast cancer revealed an association between breast cancer diagnosis and the CYP17A1 T27C polymorphism (p = 0.024).
  
  
  CONCLUSIONS
  Our study suggests no strong association between the CYP17A1 T27C and LEP -2548G>A polymorphisms and the incidence of breast cancer in Turkish women. The potential association between CYP17A1 T27C and the type of breast cancer deserves further consideration.
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.
authors.forename: Nevin
authors.initials: N
authors.lastname: Karakus
authors.forename: Nurten
authors.initials: N
authors.lastname: Kara
authors.forename: Ali N
authors.initials: AN
authors.lastname: Ulusoy
authors.forename: Cihangir
authors.initials: C
authors.lastname: Ozaslan
authors.forename: Sengul
authors.initials: S
authors.lastname: Tural
authors.forename: Ismail
authors.initials: I
authors.lastname: Okan
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D020738:Leptin / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers; D020738:Leptin; C501892:CYP17A1 protein, human; D013254:Steroid 17-alpha-Hydroxylase