title: Screening for suspected coronary heart disease in patients, using integrated serum biochemical indices.
abstract: BACKGROUND
  Many serum biochemical indices have been found to be associated with coronary heart disease (CHD); however, few studies have evaluated the value on screening CHD of the integrated serum biochemical indices.
  
  
  METHODS
  In this study, 627 healthy controls and 1049 patients with CHD were recruited to develop CHD screening models for males and females using unconditional logistic regression. The performance of the screening models was evaluated by areas under the receiver operating characteristic (ROC) curves (AUCs), and externally validated in another population comprised of 190 healthy controls and 246 patients with CHD.
  
  
  RESULTS
  Backward stepwise variable selection showed that increasing age, total cholesterol (TC), logarithm-transformed homocysteine (lnHCY), logarithm-transformed γ-glutamyl transpeptidase (lnGGT), and decreasing uric acid, logarithm-transformed triglyceride, apolipoprotein A (apoA) and apolipoprotein B (apoB), increased the detection of CHD in males. In comparison, increasing age, TC, lnHCY, lnGGT and high-density lipoprotein cholesterol versus low-density lipoprotein cholesterol, and decreasing apoA, apoB, logarithm transformed lipoprotein (A) and logarithm transformed total bilirubin, increased the detection of CHD in females. The AUCs for the screening models for males and females were 0.958 (95% CI 0.946 to 0.969) and 0.986 (95% CI 0.977 to 0.994), respectively. The performance of the screening models was further evaluated in external validation samples, the AUCs for males and females were 0.907 and 0.992, respectively.
  
  
  CONCLUSIONS
  Our study suggests that integrated serum biochemical indices may be used to screen for suspected CHD in participants.
authors.affiliation: Department of Laboratory, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Clinical Epidemiology & Biostatistics, Peking University People's Hospital, Beijing, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Intensive Care Unit, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
authors.forename: Shiyan
authors.initials: S
authors.lastname: Nian
authors.affiliation: Department of Cardiology, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
authors.forename: Yinglu
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Laboratory, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Laboratory, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
authors.forename: Xingfeng
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of the First General Surgery, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of the Second General Surgery, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D015415:Biomarkers / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers
keywords: CHD/CORONORARY HEART; Cardiovascular disease; Clinical epidemiology