title: Lack of association between +405 G/C polymorphism in VEGF and breast cancer risk: A meta-analysis.
abstract: OBJECTIVE
  To explore whether the vascular endothelial growth factor (VEGF) +405 G/C polymorphism confers susceptibility to breast cancer (BC) by conducting a meta-analysis.
  
  
  METHODS
  Publications addressing the association between the VEGF +405 G/C polymorphism and BC risk were selected from the PubMed, Embase and Google Scholar databases. Data were extracted from studies by three independent reviewers. The meta-analysis was performed by STATA 12.0 software, and odds ratio (OR) with 95% confidence interval (CI) were calculated.
  
  
  RESULTS
  Finally, 10 case-control studies were retrieved with a total of 8,855 BC patients and 9,393 controls. No significant association was identified between VEGF +405 G/C polymorphism and BC risk in overall populations under 5 models (C vs G: OR=1.001, 95% CI=0.896-1.119, p=0.987; CC vs GG: OR=1.006, 95% CI=0.853-1.186, p=0.997; CG vs GG: OR= 0.985, 95% CI=0.823-1.178, p=0.779; CC vs CGs/GG: OR=1.019, 95% CI=0.921-1.127, p=0.722; CC/CG vs GG: OR=0.985, 95% CI=0.835-1.162, p=0.862), and also in the subgroup analysis by ethnicity.
  
  
  CONCLUSIONS
  Our study confirms that there is a lack of association between the VEGF +405 G/C polymorphism and BC risk.
authors.affiliation: Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen Guangdong, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.forename: Xun
authors.initials: X
authors.lastname: Wu
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Duo
authors.initials: D
authors.lastname: Zhang
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Cai
authors.forename: Song
authors.initials: S
authors.lastname: Wu
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A