title: CLODRONATE: OLD DRUG, NEW USES.
abstract: Clodronate (CLO) is a bisphosphonate (BP) with proved efficacy in the treatment of osteoporosis. The reason of its activity is the anti-resorptive action, which is a common characteristic of BPs. Contrary to other BPs, CLO has a relatively low affinity for bone and a peculiar mechanism of action. CLO is effective in several diseases associated to excessive bone resorption as bone Pagets disease and CRPS type I. Moreover, there are data showing activity of CLO in the erosive osteoarthritis of the hands, in the osteoarthritis of the knees, in the treatment of extra-articular calcifications and in preventing the mobilization of knee and hip prosthesis.
authors.affiliation: Rheumatology and Rehabilitation Unit- Salvatore Maugeri Foundation Irccs- Castel Goffredo, Mantua, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Saviola
authors.affiliation: Rheumatology and Rehabilitation Unit- Salvatore Maugeri Foundation Irccs- Castel Goffredo, Mantua, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Abdi-Ali
authors.affiliation: Rheumatology and Rehabilitation Unit- Salvatore Maugeri Foundation Irccs- Castel Goffredo, Mantua, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Povino
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002114:Calcinosis / Q000188:drug therapy*; D004002:Clodronic Acid / Q000627:therapeutic use*; D006801:Humans; D010001:Osteitis Deformans / Q000188:drug therapy*; D010003:Osteoarthritis / Q000188:drug therapy*; D010024:Osteoporosis / Q000188:drug therapy*
chemical_list: D050071:Bone Density Conservation Agents; D004002:Clodronic Acid