title: Histomorphometric Comparison of Enzyme-Deantigenic Equine Bone and Anorganic Bovine Bone in Sinus Augmentation: A Randomized Clinical Trial with 3-Year Follow-Up.
abstract: OBJECTIVE
  To conduct a histomorphometric investigation comparing the use of enzyme-deantigenic equine bone (EDEB) and anorganic bovine bone (ABB) for maxillary sinus augmentation.
  
  
  METHODS
  Forty patients with Cawood Class V atrophic ridges who required maxillary sinus augmentation randomly received EDEB (n = 20) or ABB (n = 20) granules. Six months later, biopsy specimens were obtained, and implants were placed. Bone specimens were subjected to histomorphometric analysis, and newly formed bone (NFB) and residual biomaterial (RB) percentages were calculated. Patients were followed up for 3 years after definitive prosthetic rehabilitation, and implant success and survival rates were determined according to the criteria of Albrektsson and Zarb.
  
  
  RESULTS
  All patients healed uneventfully. Histomorphometric results for the EDEB were as follows: NFB = 46.86% ± 12.81% and RB = 11.05% ± 9.27%. For ABB, they were: NFB = 25.12% ± 7.25% and RB = 28.65% ± 9.70%. The difference was significant at a .05 level of confidence both for NFB and RB. At the 3-year follow-up, the implant survival rate was identical in the two groups (100%).
  
  
  CONCLUSIONS
  Grafting with EDEB resulted in a greater quantity of NFB at implant insertion. No significant clinical differences were observed between the two patient groups at the 3-year follow-up. EDEB was as effective as ABB for sinus augmentation.
authors.forename: Danilo Alessio
authors.initials: DA
authors.lastname: Di Stefano
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gastaldi
authors.forename: Raffaele
authors.initials: R
authors.lastname: Vinci
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cinci
authors.forename: Laura
authors.initials: L
authors.lastname: Pieri
authors.forename: Enrico
authors.initials: E
authors.lastname: Gherlone
mesh_terms: D000368:Aged; D000818:Animals; D001284:Atrophy; D001706:Biopsy / Q000379:methods; D016025:Bone Transplantation / Q000379:methods*; D002113:Calcification, Physiologic / Q000502:physiology; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D005260:Female; D005500:Follow-Up Studies; D064593:Heterografts / Q000473:pathology / Q000637:transplantation*; D006736:Horses; D006801:Humans; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D010006:Osteoblasts / Q000473:pathology; D010011:Osteocytes / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D059546:Sinus Floor Augmentation / Q000379:methods*; D016019:Survival Analysis; D014021:Tissue Preservation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D015921:Dental Implants