title: Using Magnetic Resonance for Predicting Femoral Strength: Added Value with respect to Bone Densitometry.
abstract: OBJECTIVE
  To evaluate the added value of MRI with respect to peripheral quantitative computed tomography (pQCT) and dual energy X-ray absorptiometry (DXA) for predicting femoral strength.
  
  
  METHODS
  Bone mineral density (BMD) of eighteen femur specimens was assessed with pQCT, DXA, and MRI (using ultrashort echo times (UTE) and the MicroView software). Subsequently biomechanical testing was performed to assess failure load. Simple and multiple linear regression were used with failure load as the dependent variable.
  
  
  RESULTS
  Simple linear regression allowed a prediction of failure load with either pQCT, DXA, or MRI in an r(2) range of 0.41-0.48. Multiple linear regression with pQCT, DXA, and MRI yielded the best prediction (r(2) = 0.68).
  
  
  CONCLUSIONS
  The accuracy of MRI, using UTE and MicroView software, to predict femoral strength compares well with that of pQCT or DXA. Furthermore, the inclusion of MRI in a multiple-regression model yields the best prediction.
authors.affiliation: Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
authors.forename: Olivia
authors.initials: O
authors.lastname: Louis
authors.affiliation: Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
authors.forename: Yves
authors.initials: Y
authors.lastname: Fierens
authors.affiliation: Department of Mechanics of Materials and Constructions, Vrije Universiteit Brussel, Pleinlaan 2, 1040 Brussels, Belgium.
authors.forename: Maria
authors.initials: M
authors.lastname: Strantza
authors.affiliation: Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
authors.forename: Robert
authors.initials: R
authors.lastname: Luypaert
authors.affiliation: Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: de Mey
authors.affiliation: Department of Experimental Anatomy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
authors.forename: Erik
authors.initials: E
authors.lastname: Cattrysse
mesh_terms: D015502:Absorptiometry, Photon; D001696:Biomechanical Phenomena; D015519:Bone Density; D003720:Densitometry / Q000379:methods*; D005269:Femur / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed