title: [Antimicrobial Effects of Iodine-Polyvinyl Alcohol Ophthalmic and Eye Washing Solution (PA * IODO) with Special Reference to its Temperature, Concentration and Time and its Preservation Stability].
abstract: OBJECTIVE
  Temperature, concentration and time are the three factors that affect the inactivation capacity of iodine antiseptics. We investigated the effect of these factors on the microbe inactivation of Iodine-Polyvinyl Alcohol ophthalmic and eye washing solution (PA * IODO), and also investigated the preservation conditions on stability of the inactivation activity of the PA * IODO.
  
  
  METHODS
  Test microbes were mixed with PA * IODO, varying the three factors. The live microbes were counted after each reaction. The effects of plugging and preservation temperature were investigated to determine the preserving stability.
  
  
  RESULTS
  The inactivation capacity of PA * IODO tended to decrease in almost all microbes tested at 4 degrees C. Twenty times or less diluted PA * IODO killed almost all microbes completely. The time effect was more marked in viruses. Plugging and low-temperature made iodine concentration in diluted PA * IODO remain relatively high.
  
  
  CONCLUSIONS
  The concentration of PA * IODO affected the inactivation ability more than the temperature and time, although all the three factors correlated positively to the inactivation. For preservation the diluted PA * IODO needed plugging and low temperature.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hatano
authors.forename: Masako
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hayashi
authors.forename: Seigo
authors.initials: S
authors.lastname: Kamiya
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004355:Drug Stability; D007455:Iodine / Q000494:pharmacology*; D050296:Microbial Viability / Q000187:drug effects*; D009883:Ophthalmic Solutions / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000494:pharmacology*; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical; D011142:Polyvinyl Alcohol; D007455:Iodine