title: Invasive Fusariosis: A Single Pediatric Center 15-Year Experience.
abstract: Invasive fungal infection (IFI) is an important cause of mortality in immunocompromised children, particularly after hematopoietic stem cell transplantation. We describe 5 cases of Fusarium IFI in immunocompromised children seen at our institution over a 15-year period. A summary of all published pediatric cases of invasive Fusarium infection is presented. A focus on antifungal management challenges in these patients will be discussed.
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics.
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Schwartz
authors.affiliation: Department of Pediatrics.
authors.forename: Holden
authors.initials: H
authors.lastname: Sheffield
authors.affiliation: Division of Microbiology, Department of Laboratory Medicine.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Richardson
authors.affiliation: Division of Haematology/Oncology and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, University of Toronto, Canada.
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics.
authors.forename: Shaun K
authors.initials: SK
authors.lastname: Morris
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology; D002170:Canada; D002648:Child; D002675:Child, Preschool; D060085:Coinfection; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000379:methods*; D005260:Female; D060585:Fusariosis / Q000150:complications / Q000188:drug therapy* / Q000401:mortality*; D005670:Fusarium / Q000187:drug effects / Q000472:pathogenicity; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008099:Liver / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology; D008168:Lung / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D009503:Neutropenia / Q000188:drug therapy / Q000382:microbiology; D010256:Paranasal Sinuses / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology; D012867:Skin / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology
chemical_list: D000935:Antifungal Agents
keywords: Fusarium; children; hematopoietic stem cell transplantation; immunocompromised host; invasive fungal infection