title: Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders.
abstract: Systemic inflammatory disorders resulting from infection, trauma, surgery, and severe disease conditions pose serious threats to human health leading to organ dysfunction, organ failure, and mortality. The highly complex and dynamic nature of the immune system experiencing acute inflammation makes immunomodulatory therapy blocking pro-inflammatory cytokines very challenging. Successful therapy requires the ability to determine appropriate anti-cytokine drugs to be delivered at a right dose in a timely manner. Label-free micro- and nano-biosensors hold the potential to overcome the current challenges, enabling cytokine-targeted treatments to be tailored according to the immune status of an individual host with their unique cytokine biomarker detection capabilities. This review studies the recent progress in label-free cytokine biosensors, summarizes their performances and potential merits, and discusses future directions for their advancements to meet challenges towards personalized anti-cytokine drug delivery.
authors.affiliation: University of Michigan, College of Engineering, Department of Mechanical Engineering, USA.
authors.forename: Pengyu
authors.initials: P
authors.lastname: Chen
authors.affiliation: National Taiwan University, Graduate Institute of Biomedical Electronics and Bioinformatics, Department of Electrical Engineering, Taiwan.
authors.forename: Nien-Tsu
authors.initials: NT
authors.lastname: Huang
authors.affiliation: University of Michigan, College of Engineering, Department of Mechanical Engineering, USA.
authors.forename: Meng-Ting
authors.initials: MT
authors.lastname: Chung
authors.affiliation: University of Michigan Medical School, Department of Pediatrics and Communicable Diseases, USA.
authors.forename: Timothy T
authors.initials: TT
authors.lastname: Cornell
authors.affiliation: University of Michigan, College of Engineering, Department of Mechanical Engineering, USA; University of Michigan, College of Engineering, Department of Electrical Engineering and Computer Science, USA. Electronic address: katsuo@umich.edu.
authors.forename: Katsuo
authors.initials: K
authors.lastname: Kurabayashi
mesh_terms: D015374:Biosensing Techniques; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007118:Immunoassay; D007249:Inflammation / Q000276:immunology / Q000628:therapy*; D044085:Microfluidics; D050997:Nanomedicine; D057285:Precision Medicine
chemical_list: D016207:Cytokines
keywords: Anti-Cytokine Drug Delivery; Field Effect Transistor Nanowire; Label-free Biosensors; Microcantilever; Microfluidics; Optical Resonator; Personalized Medicine; Pro-inflammatory Cytokine; Surface Plasmon Resonance