title: The predictive value of red cell distribution width levels on mortality in intensive care patients with community-acquired intra-abdominal sepsis.
abstract: BACKGROUND
  Red cell distribution width (RDW) is a part of the complete blood count (CBC) panel reflecting quantitative measure of variability in the size of circulating red blood cells. It has been known that higher RDW is associated with increased mortality in several diseases. The aim of this study was to investigate the association between RDW and hospital mortality in intensive care unit (ICU) patients with community-acquired intra-abdominal sepsis (C-IAS).
  
  
  METHODS
  A retrospective analysis of the patients with C-IAS was performed between January 1, 2010 and March 31, 2013. Patients' demographics, co-morbidities, laboratory measures including RDW on admission to the ICU, and Acute Physiologic and Chronic Health Evaluation II (APACHE II) score were analyzed.
  
  
  RESULTS
  A total of one hundred and three patients with C-IAS were included into the study with a mean age of 64±14 years. Overall mortality was 50.5%. RDW day 1 (RDW1) values and APACHE II scores were significantly higher in non-survivors than in survivors. In multivariate analysis, only RDW1 and APACHE II predicted mortality. The area under the receiver operating curves (AUC) of RDW1 and APACHE II were 0.867 (95% CI, 0.791-0.942) and 0.943 (95% CI, 0.902-0.984), respectively.
  
  
  CONCLUSIONS
  This study suggests that increased RDW is associated with mortality in ICU patients with C-IAS.
authors.affiliation: Department of Anesthesia and Reanimation, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Hatice Kaya
authors.initials: HK
authors.lastname: Özdoğan
authors.affiliation: Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Karateke
authors.affiliation: Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Sefa
authors.initials: S
authors.lastname: Özyazıcı
authors.affiliation: Department of General Surgery, Medical Park Hospital, Adana, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Özdoğan
authors.affiliation: Department of Biostatistics, Cukurova University Faculty of Medicine, Adana, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Özaltun
authors.affiliation: Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Kuvvetli
authors.affiliation: Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Gökler
authors.affiliation: Department of Anesthesia and Reanimation, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ersoy
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001772:Blood Cell Count; D003422:Critical Care; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood / Q000401:mortality*; D055815:Young Adult