title: Profile of hMSH2 expression in breast tumors and lymph nodes: a preliminary study.
abstract: OBJECTIVE
  The mismatch repair (MMR) genes play a central role for the onset of cancer. One of these genes is hMSH2. A differential hMSH2 protein expression has been detected in the mononuclear fraction of peripheral blood of patients with breast cancer when compared to healthy women. This work aims to evaluate the expression of hMSH2 in patients diagnosed with breast cancer undergoing treatment at various stages of the disease to verify its potential use as a prognostic marker.
  
  
  METHODS
  Immunohistochemical expression of hMSH2 at different stages of breast cancer in 40 patients biopsy samples were analyzed.
  
  
  RESULTS
  hMSH2 has a considerable increased expression in all groups of patients with tumors, when compared to patients without tumors.
  
  
  CONCLUSIONS
  immunohistochemistry indeed can be a great tool for the diagnosis of breast cancer, as it is an easy and versatile technique.
authors.affiliation: Department of Oncology, ABC Medical School, Santo André, SP, Brazil. bcaalves@uol.com.br.
authors.forename: D
authors.initials: D
authors.lastname: Lira
authors.forename: T R
authors.initials: TR
authors.lastname: Teodoro
authors.forename: M A da Silva
authors.initials: MA
authors.lastname: Pinhal
authors.forename: F L Affonso
authors.initials: FL
authors.lastname: Fonseca
authors.forename: F de Sousa
authors.initials: Fde S
authors.lastname: Gehrke
authors.forename: L A
authors.initials: LA
authors.lastname: Azzalis
authors.forename: V B de Campos
authors.initials: VB
authors.lastname: Junqueira
authors.forename: B da Costa Aguiar
authors.initials: Bda C
authors.lastname: Alves
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D053843:DNA Mismatch Repair; D005260:Female; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000378:metabolism*; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D009687:Nuclear Proteins; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein