title: Fibroblast Growth Factor 23 and Incidence of Subarachnoid Hemorrhage: Nested Case-Control Study.
abstract: OBJECTIVE
  Fibroblast growth factor 23 (FGF23) is a hormone with regulatory effects on mineral metabolism and arterial calcification. We aimed to study the association between FGF23 and risk of incident subarachnoid hemorrhage (SAH) in a nested case-control study.
  
  
  METHODS
  FGF23 was analyzed in stored blood samples from incident SAH cases (n=79) and control subjects (n=232), participating in the prospective, population-based Malmö Diet and Cancer Study. The association between FGF23 and SAH was studied using conditional logistic regression.
  
  
  RESULTS
  High FGF23 was associated with incident SAH. In the highest compared with the lowest quartile of FGF23, the odds ratio for SAH was 3.28 (95% confidence interval, 1.34-8.00), P for trend=0.006, after adjustment for SAH risk factors.
  
  
  CONCLUSIONS
  High FGF23 was associated with increased risk of incident SAH in subjects from the general population. Further studies should elucidate whether FGF23 is a causal risk factor for SAH, or could be used in risk prediction.
authors.affiliation: From the Cardiovascular Epidemiology Research Group, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden (M.S., G.E.); and Department of Neurology, Skåne University Hospital, Malmö, Sweden (M.S.). martin.soderholm@med.lu.se.
authors.forename: Martin
authors.initials: M
authors.lastname: Söderholm
authors.affiliation: From the Cardiovascular Epidemiology Research Group, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden (M.S., G.E.); and Department of Neurology, Skåne University Hospital, Malmö, Sweden (M.S.).
authors.forename: Gunnar
authors.initials: G
authors.lastname: Engström
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000453:epidemiology; D013548:Sweden / Q000453:epidemiology
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
keywords: fibroblast growth factors; risk factors; subarachnoid hemorrhage