title: [ALLOCATION OF ZINC, MAGNESIUM AND COPPER IN GRANULOCYTES AND SERUM OF RABBITS WHILE INTRODUCTION OF SUBSTANCES THAT CHANGE THE FUNCTIONAL STATE OF ADRENAL CORTEX AND THE AUTONOMIC NERVOUS SYSTEM].
abstract: It was investigate the content of zinc, magnesium and copper in granulocytes and blood serum of the rabbits, that were injected with substances, that change the functional state of adrenal cortex, sympathetic-adrenal and parasympathetic nervous systems. It has been found that adrenaline, prednisolone and pilocarpine caused the multidirectional changes of these metals content in cells and in extracellular space. In this significant increase of zinc concentration by 33 - 42%, magnesium--by 33 -50%, and also decrease of copper content by 25-50% was observed in granulocytes of animals after adrenal hormones injections. Under the influence of cholinomimetics content of zinc and magnesium were essential decreased in granulocytes of the rabbits, by 58% and by 33% respectively, and content of copper was risen by 43% (P < 0.001). The opposite pattern was observed in serum. Adrenaline and prednisolone prescription caused a significant decrease of zinc concentration by 20-24%, magnesium--by 22-33%, and increase of copper content by 36-43%. Pilocarpine injection caused a decrease of zinc and magnesium content by 28 and 33% (P < 0.01) respectively, and an increase of copper concentration by 43% (P < 0.001). The obtained results also indicate a synergistic relationship between zinc and magnesium in cells, but antagonistic--these metals with copper.
authors.forename: N V
authors.initials: NV
authors.lastname: Grigorova
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology; D002413:Cations, Divalent; D018678:Cholinergic Agents / Q000494:pharmacology; D003300:Copper / Q000097:blood*; D004837:Epinephrine / Q000494:pharmacology; D005110:Extracellular Space / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D005938:Glucocorticoids / Q000494:pharmacology; D006098:Granulocytes / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008274:Magnesium / Q000097:blood*; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D010862:Pilocarpine / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D013566:Sympathomimetics / Q000494:pharmacology; D015032:Zinc / Q000097:blood*
chemical_list: D002413:Cations, Divalent; D018678:Cholinergic Agents; D005938:Glucocorticoids; D013566:Sympathomimetics; D010862:Pilocarpine; D003300:Copper; D011239:Prednisolone; D008274:Magnesium; D015032:Zinc; D004837:Epinephrine