title: Prediction of background parenchymal enhancement on breast MRI using mammography, ultrasonography, and diffusion-weighted imaging.
abstract: This retrospective study assessed the effects of menopausal status and menstrual cycle on background parenchymal enhancement (BPE) of breast magnetic resonance imaging (MRI), and investigated whether the degree of BPE can be predicted by findings of mammography, ultrasonography (US), and diffusion-weighted MR imaging (DWI). There were 160 study patients (80 premenopausal, 80 postmenopausal). Degree of BPE was classified into minimal, mild, moderate, or marked. Mammographic density was classified into fatty, scattered, heterogeneously dense, and extremely dense. BP echotexture on US and BP intensity on DWI were visually classified as homogeneous or heterogeneous. Apparent diffusion coefficient (ADC) values of normal breast tissue were measured. Associations of the degree of BPE with menopausal status, menstrual cycle, or imaging features were evaluated by univariate and multivariate analyses. No significant correlation was found between mammographic density and BPE (p=0.085), whereas menopausal status (p=0.000), BP echotexture (p=0.000), and BP intensity on DWI (p= 0.000), and ADC values (p=0.000) showed significant correlations with BPE. Multivariate analysis showed that postmenopausal status was an independent predictor of minimal BPE (p=0.002, OR=3.743). In premenopausal women, there was no significant correlation between menstrual cycle and BPE, whereas BP echotexture was an independent predictor of whether BPE was less than mild or greater than moderate (p=0.001, OR=26.575). BPE on breast MRI is associated with menopausal status and the findings of US and DWI. Because premenopausal women with heterogeneous BP echotexture may be predicted to show moderate or marked BPE, scheduling of breast MRI should preferentially be adjusted to the menstrual cycle.
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Kawamura
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Satake
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Ishigaki
authors.affiliation: Department of Technical Radiology, Nagoya University School of Health Science, Nagoya, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ikeda
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Kimura
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimamoto
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
keywords: background parenchymal enhancement; diffusion-weighted imaging (DWI); menopausal status, mammography; ultrasonography (US)