title: Endocannabinoids and Mental Disorders.
abstract: Preclinical and clinical data fully support the involvement of the endocannabinoid system in the etiopathogenesis of several mental diseases. In this review we will briefly summarize the most common alterations in the endocannabinoid system, in terms of cannabinoid receptors and endocannabinoid levels, present in mood disorders (anxiety, posttraumatic stress disorder, depression, bipolar disorder, and suicidality) as well as psychosis (schizophrenia) and autism. The arising picture for each pathology is not always straightforward; however, both animal and human studies seem to suggest that pharmacological modulation of this system might represent a novel approach for treatment.
authors.affiliation: Department of Theoretical and Applied Sciences and Neuroscience Centre, University of Insubria, Via Manara 7, 21052, Busto Arsizio, VA, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Rubino
authors.affiliation: Department of Theoretical and Applied Sciences and Neuroscience Centre, University of Insubria, Via Manara 7, 21052, Busto Arsizio, VA, Italy.|Fondazione Zardi Gori, Milan, Italy.
authors.forename: Erica
authors.initials: E
authors.lastname: Zamberletti
authors.affiliation: Department of Theoretical and Applied Sciences and Neuroscience Centre, University of Insubria, Via Manara 7, 21052, Busto Arsizio, VA, Italy. daniela.parolaro@uninsubria.it.|Fondazione Zardi Gori, Milan, Italy. daniela.parolaro@uninsubria.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Parolaro
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D063386:Cannabinoid Receptor Agonists / Q000627:therapeutic use; D063387:Cannabinoid Receptor Antagonists / Q000627:therapeutic use; D063388:Endocannabinoids / Q000378:metabolism*; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D011618:Psychotic Disorders / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism; D043885:Receptor, Cannabinoid, CB2 / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D063386:Cannabinoid Receptor Agonists; D063387:Cannabinoid Receptor Antagonists; D063388:Endocannabinoids; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2
keywords: Autism; Bipolar disorder and suicidality; Depression; Endocannabinoid system anxiety; Posttraumatic stress disorder; Schizophrenia