title: Psychiatric manifestations of 22q11.2 deletion syndrome: a literature review.
abstract: BACKGROUND
  The 22q11.2 deletion syndrome is a genetic disorder with variable clinical manifestations. It affects one out of 5950 neonates and has an autosomal dominant inheritance pattern. The aim of this article is to review its psychiatric manifestations and any underlying genetic alterations.
  
  
  METHODS
  We reviewed the scientific literature available as of October 2014 in the LILACS and Medline databases.
  
  
  RESULTS
  Sixty per cent of these patients fulfilled diagnostic criteria for a mental disorder at some point in their lives, referring to psychotic disorders, attention deficit hyperactivity disorder, mood disorders, anxiety disorders, and autism spectrum disorders. Specific genes, such as COMT and PRODH, have been linked to these psychiatric manifestations.
  
  
  CONCLUSIONS
  It is necessary to raise awareness among all health care professionals so that they understand the relevance of these manifestations, are able to anticipate them, and can provide appropriate information to patients and family members.
authors.affiliation: Departamento de Neuropediatría, Hospital Roberto del Río-Universidad de Chile, Santiago, Chile.
authors.forename: M
authors.initials: M
authors.lastname: Bertrán
authors.affiliation: Pontificia Universidad Católica de Chile, Santiago, Chile; Instituto Milenio para la Investigación en Depresión y Personalidad, Santiago, Chile.
authors.forename: F P
authors.initials: FP
authors.lastname: Tagle
authors.affiliation: Departamento de Psiquiatría de Niños y Adolescentes, Clínica Psiquiátrica Universitaria-Hospital Clínico Universidad de Chile, Clínica Las Condes, Santiago, Chile; Instituto Milenio para la Investigación en Depresión y Personalidad, Santiago, Chile. Electronic address: mirarrazavald@u.uchile.cl.
authors.forename: M
authors.initials: M
authors.lastname: Irarrázaval
mesh_terms: D015897:Comorbidity; D004062:DiGeorge Syndrome / Q000150:complications* / Q000235:genetics*; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology*
keywords: 22q11.2 deletion syndrome; Comorbilidades psiquiátricas; Genetics; Genética; Psychiatric comorbidity; Síndrome de deleción 22q11.2