title: Vascular invasion in uterine sarcomas and its significance. A multi-institutional study.
abstract: Although metastases and high-mortality are frequent in high-grade endometrial sarcomas (HGSs), these findings are less commonly seen in low-grade endometrial stromal sarcomas (LGESSs), even in cases with lymphovascular invasion (LVI). We hypothesized that the "bulging plugs" of tumor characteristic of LVI in LGESS are fundamentally different from LVI seen in HGS. We reviewed 70 uterine sarcomas: 42 HGSs (high-grade endometrial stromal sarcomas, undifferentiated uterine sarcoma, and leiomyosarcoma) and 28 LGESSs. All cases had LVI documented on the histologic slides. Immunostains for CD31, ERG, and D2-40 were performed. LGESS harbored cohesive intravascular tumor foci with direct communication from the main tumor and attached to the vessel wall. The intravascular foci included tumor cells and small arteriole-type vessels and were surrounded by a thin fibrous band. Vascular markers confirmed the LVI and highlighted positively stained endothelial cells separating intravascular tumor foci from the blood itself. In contrast, intravascular tumor foci in HGS were composed of discohesive cells clusters, lacking the features described in LGESS. Only 8 (30.8%) patients with LGESS had recurrence/metastases (6 with lung metastasis); only 1 patient died of disease. Thirty (77%) patients with HGS had recurrence/metastases, 27 (69%) patients had lung metastases, and 22 (56.4%) patients died of disease. We propose that in most LGESSs, LVI represents vascular intrusion; manipulation or trauma is potentially responsible for tumor cell detachment into the circulation increasing the chances of recurrence/metastases. Classic LVI features were identified in HGS. This important distinction may allow for better management of patients and avoid unnecessary treatment in LGESS, reducing morbidity.
authors.affiliation: Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH 44195. Electronic address: romaa@ccf.org.
authors.forename: Andres A
authors.initials: AA
authors.lastname: Roma
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, 90048.
authors.forename: Denise A
authors.initials: DA
authors.lastname: Barbuto
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, 90048.
authors.forename: Siavash Azadmanesh
authors.initials: SA
authors.lastname: Samimi
authors.affiliation: Targu Mures University of Medicine and Pharmacy, Targu Mures, 540139, Romania.
authors.forename: Simona
authors.initials: S
authors.lastname: Stolnicu
authors.affiliation: Mexican Oncology Hospital, Mexico City, DF 06720, Mexico.
authors.forename: Isabel
authors.initials: I
authors.lastname: Alvarado-Cabrero
authors.affiliation: Instituto Nacional de Cancerologia (Mexico), Mexico City DF 14080, Mexico.
authors.forename: Jose
authors.initials: J
authors.lastname: Chanona-Vilchis
authors.affiliation: Medical College of Wisconsin, Milwaukee, 53226, WI.
authors.forename: Irene
authors.initials: I
authors.lastname: Aguilera-Barrantes
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, 90048.
authors.forename: Mariza
authors.initials: M
authors.lastname: de Peralta-Venturina
authors.affiliation: The University of Texas MD Anderson Cancer Center, Houston, 77030, TX.
authors.forename: Anais
authors.initials: A
authors.lastname: Malpica
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, 90048.
authors.forename: Joanne K L
authors.initials: JK
authors.lastname: Rutgers
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, 90048; The University of Texas MD Anderson Cancer Center, Houston, 77030, TX.
authors.forename: Elvio G
authors.initials: EG
authors.lastname: Silva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology*; D018203:Sarcoma, Endometrial Stromal / Q000473:pathology; D014594:Uterine Neoplasms / Q000473:pathology*
keywords: Leiomyosarcoma; Low-grade endometrial stromal sarcomas; Lymphvascular invasion; Undifferentiated uterine sarcoma; Uterine sarcoma