title: In vitro avarol does affect the growth of Candida sp.
abstract: This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0 μg/mL and MFC 1.6-12.0 μg/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo.
authors.affiliation: a Institute of Biomolecular Chemistry, CNR-ICB , National Research Council of Italy , Pozzuoli-Naples , Italy.|b Department of Life Sciences, Institute for Multidisciplinary Research - IMSI , University of Belgrade , Belgrade , Serbia.
authors.forename: Boris
authors.initials: B
authors.lastname: Pejin
authors.affiliation: c Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research 'Sinisa Stankovic', IBISS , University of Belgrade , Belgrade , Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Ciric
authors.affiliation: d Faculty of Dental Medicine, Department of Pediatric and Preventive Dentistry , University of Belgrade , Belgrade , Serbia.
authors.forename: Dejan
authors.initials: D
authors.lastname: Markovic
authors.affiliation: a Institute of Biomolecular Chemistry, CNR-ICB , National Research Council of Italy , Pozzuoli-Naples , Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Tommonaro
authors.affiliation: c Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research 'Sinisa Stankovic', IBISS , University of Belgrade , Belgrade , Serbia.
authors.forename: Marina
authors.initials: M
authors.lastname: Sokovic
mesh_terms: D000818:Animals; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; C023663:avarol
keywords: Alzheimer’s disease; Dysidea avara; Marine sponge; anticandidial activity; avarol; oral pathogens