title: THE RISK OF HYPERCOAGULABILITY IN OVARIAN HYPERSTIMULATION SYNDROME.
abstract: Ovarian hyperstimulation syndrome (OHSS) is a rare and potentially life-threatening complication of infertility treatment occurring during either the luteal phase or early pregnancy. An increasing number of thromboembolic complications associated with the increased use of assisted reproductive techniques have been reported in the literature. Identification of the risk factors is crucial for prevention of thromboembolic events in OHSS patients. Alterations in the hemostatic system cause hypercoagulability in women affected by severe OHSS. Coexistence of inherited hypercoagulable conditions increases the risk of thromboembolism. The role of clinical parameters that can help predict development of thrombosis is controversial. Patients with a personal or family history of thrombosis undergoing infertility treatment should be considered for thrombophilia screening, while routine examination of inherited thrombophilic mutations is not indicated in infertile patients. Antithrombotic primary prevention is not indicated in healthy women undergoing assisted reproductive procedures or in women with thrombophilia. Anticoagulant therapy is indicted if there is clinical evidence of thrombosis or laboratory evidence of hypercoagulability. In this review, the risks of hypercoagulability in the OHSS are discussed.
authors.forename: Damir
authors.initials: D
authors.lastname: Danolić
authors.forename: Miro
authors.initials: M
authors.lastname: Kasum
authors.forename: Mario
authors.initials: M
authors.lastname: Puljiz
authors.forename: Ilija
authors.initials: I
authors.lastname: Alvir
authors.forename: Darko
authors.initials: D
authors.lastname: Tomica
authors.forename: Ivica
authors.initials: I
authors.lastname: Mamić
authors.forename: Ermin
authors.initials: E
authors.lastname: Čehić
authors.forename: Ivan
authors.initials: I
authors.lastname: Bolanča
mesh_terms: D001777:Blood Coagulation; D005260:Female; D014943:Global Health; D006801:Humans; D009017:Morbidity / Q000639:trends; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood / Q000453:epidemiology / Q000209:etiology