title: The novel association between red complex of oral microbe and body mass index in healthy Japanese: a population based cross-sectional study.
abstract: Microbiota has been thought to be one of important environmental factors for obesity or Type 2 diabetes mellitus. Among oral microbe, Porphyromonas gingivalis, Treponema denticola and Tannellera forsythia are known as risk factors, so called red complex, for periodontitis. Red complex could also be a risk factor for obesity. However, recent study indicated that obesity was not improved by periodontal therapy. Thus, we performed a cross sectional study to reveal the association of oral microbe with body mass index in a healthy population. Healthy individuals were randomly recruited. The infections of oral microbe were identified by Taqman polymerase chain reaction. The relationships between number of red complex and body mass index or waist circumference were analyzed. Two hundred and twenty-two apparently healthy Japanese were enrolled. BMI and waist circumference as well as age, periodontitis, number of brushing teeth were significantly associated with the number of red complex after adjusting covariance. The effect size of body mass index or waist circumference was 0.023 (p = 0.028) or 0.024 (p = 0.024), respectively. Body mass index and waist circumference were independently associated with the number of red complex among apparently healthy Japanese. The current observation implies the possibility that oral microbe was associated with obesity in healthy population.
authors.affiliation: Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Matsushita
authors.affiliation: Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Hamaguchi
authors.affiliation: Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shougoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Motomu
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamazaki
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shougoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Yamazaki
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shougoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Asai
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shougoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamori
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shougoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Bessho
authors.affiliation: Health Checkup Center, Oike Clinic, 11 Nishino-Kyo, Shimoai-cho, Nakagyo-ku, Kyoto 604-8431, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Toda
authors.affiliation: Division of Metabolism, Nephrology and Rheumatology, Japanese Red Cross Kyoto Daini Hospital, 355-5 Haruobi-cho, Kamigyo-ku, Kyoto 602-8031, Japan.
authors.forename: Goji
authors.initials: G
authors.lastname: Hasegawa
authors.affiliation: Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Nakamura
authors.affiliation: Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
authors.forename: Michiaki
authors.initials: M
authors.lastname: Fukui
keywords: body mass index; obesity; oral microbe; red complex; waist circumference