title: Clinical significance and prognostic value of Vav1 expression in Non-small cell lung cancer.
abstract: Vav1 has been reported to be involved in human cancers, however, the expression and clinical significance of Vav1 in NSCLC are not fully understood. In the present study, we examined the expression of Vav1 in 170 NSCLC patients who underwent radical resection by the immunohistochemical analyses. The association between the Vav1 expression and clinicopathological variables was analyzed. The multivariate Cox proportional hazards model was conducted to determine the prognostic value of Vav1 on the long-term survival. The results showed that the elevated Vav1 expression was correlated positively with lymph node metastasis (P<0.001), T stage (P<0.001) and poor histological differentiation (P<0.001). Patients with negative or low Vav1 expression had better prognoses than those with high Vav1 expression (P<0.001). Multivariate analysis indicated that Vav1 was independent prognostic factor for overall survival (OS) (HR 2.079, 95% CI 1.564 to 2.762, P<0.001) and disease-free survival (DFS) (HR 1.810, 95% CI 1.391 to 2.356, P<0.001). Our findings showed that overexpressed Vav1 was correlated with aggressive tumor behavior. Val1 was an independent factor for NSCLC prognosis, which may serve as a novel prognostic factor and potential target to improve the long-term outcome of NSCLC.
authors.affiliation: Department of Hematology, Tianjin First Center Hospital Fukang Road, Nankai District, Tianjin 300192, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of TCM Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Fan-Ming
authors.initials: FM
authors.lastname: Kong
authors.affiliation: Department of Hematology, Tianjin First Center Hospital Fukang Road, Nankai District, Tianjin 300192, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Deng
authors.affiliation: Department of Hematology, Tianjin First Center Hospital Fukang Road, Nankai District, Tianjin 300192, China.
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Li
authors.affiliation: Department of Hematology, Tianjin First Center Hospital Fukang Road, Nankai District, Tianjin 300192, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Cui
authors.affiliation: Department of Hematology, Tianjin First Center Hospital Fukang Road, Nankai District, Tianjin 300192, China.
authors.forename: Ye-Di
authors.initials: YD
authors.lastname: Pu
authors.affiliation: Department of Pathology, Tianjin Medical University Cancer Institute and Hospital Tiyuanbei Road, Hexi District, Tianjin 300060, China.
authors.forename: Qiong-Li
authors.initials: QL
authors.lastname: Zhai
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of TCM Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Jia
authors.affiliation: Department of Hematology, Tianjin First Center Hospital Fukang Road, Nankai District, Tianjin 300192, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Li
keywords: Vav1; invasion; non-small cell lung cancer; prognosis