title: Persistent and Prolonged Parvovirus B19 Viremia in a Pediatric Patient With Acute Lymphoblastic Leukemia.
abstract: Parvovirus B19 is a small single-stranded DNA virus of the Parvoviridae family. Depending on host factors, it may produce a wide array of clinical disease states. Disease severity can range from self-limited to severe, requiring significant supportive care. Immunocompromised patients are generally affected more severely but rarely develop prolonged and persistent infections. Here, we describe a patient who was diagnosed with parvovirus during maintenance therapy for acute lymphoblastic leukemia and required therapy with intravenous immunoglobulin; the patient remained parvovirus positive according to a polymerase chain reaction testing but had no clinical symptoms for 27 months off chemotherapy.
authors.affiliation: Division of Pediatric Hematology-Oncology.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Fritch Lilla
authors.affiliation: Division of Pediatric Hematology-Oncology.
authors.forename: Shelly E
authors.initials: SE
authors.lastname: Burgett
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: McGann
authors.affiliation: Division of Pediatric Hematology-Oncology.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Wechsler
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D058345:Asymptomatic Infections; D002648:Child; D006801:Humans; D016867:Immunocompromised Host; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D010322:Parvoviridae Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D016732:Parvovirus B19, Human; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy*; D014766:Viremia
chemical_list: D000970:Antineoplastic Agents; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D015122:Mercaptopurine; D008727:Methotrexate
keywords: anemia; immunocompromised; leukemia; parvovirus; pediatric