title: The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus.
abstract: We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells. Autologous mesenchymal stem cells were injected intravenously (intact cells) or via lumbar puncture (cells committed to neuronal differentiation). Evaluation of the results of cell therapy after 12-month follow-up revealed slowing down of the disease progression in 10 patients in comparison with the control group consisting of 15 patients. The cell therapy was safe for the patients.
authors.affiliation: Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus. rushkevich@tut.by.
authors.forename: Yu N
authors.initials: YN
authors.lastname: Rushkevich
authors.affiliation: Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus.
authors.forename: S M
authors.initials: SM
authors.lastname: Kosmacheva
authors.affiliation: Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus.
authors.forename: G V
authors.initials: GV
authors.lastname: Zabrodets
authors.affiliation: Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus.
authors.forename: S I
authors.initials: SI
authors.lastname: Ignatenko
authors.affiliation: Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus.
authors.forename: N V
authors.initials: NV
authors.lastname: Goncharova
authors.affiliation: Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus.
authors.forename: I N
authors.initials: IN
authors.lastname: Severin
authors.affiliation: Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus.
authors.forename: S A
authors.initials: SA
authors.lastname: Likhachev
authors.affiliation: Belorussian State Medical University, Minsk, Belarus.
authors.forename: M P
authors.initials: MP
authors.lastname: Potapnev
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D002454:Cell Differentiation; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000201:enzymology; D008875:Middle Aged; D064231:Nestin / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D002094:Republic of Belarus; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: C577484:NES protein, human; D064231:Nestin; D010751:Phosphopyruvate Hydratase
keywords: ALSFRS-R; Karnofsky scale; amyotrophic lateral sclerosis; autologous mesenchymal stem cells; neurogenic differentiation