title: Extracellular Biocoordinated Zinc Nanofibers Inhibit Malignant Characteristics of Cancer Cell.
abstract: Inhibition of the heat shock proteins (HSPs) has been considered to be one of the promising strategies for cancer treatment. However, developing highly effective HSP inhibitors remains a challenge. Recent studies on the evolutionarily distinct functions between intracellular and extracellular HSPs (eHSPs) trigger a new direction with eHSPs as chemotherapeutic targets. Herein, the first engineered eHSP nanoinhibitor with high effectiveness is reported. The zinc-aspartic acid nanofibers have specific binding ability to eHSP90, which induces a decrease in the level of the tumor marker-gelatinases, consequently resulting in downregulation of the tumor-promoting inflammation nuclear factor-kappa B signaling, and finally inhibiting cancer cell proliferation, migration, and invasion; while they are harmless to normal cells. Our findings highlight the potential for cancer treatment by altering the key determinants that shape its ability to adapt and evolve using novel nanomaterials.
authors.affiliation: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xin
authors.affiliation: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology , Beijing 100190, China.|School of Life Sciences, Jilin University , Changchun 130012, China.
authors.forename: Haihui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Zejian
authors.initials: Z
authors.lastname: Dong
authors.affiliation: School of Life Sciences, Jilin University , Changchun 130012, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Xiang
authors.affiliation: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Jian Ru
authors.initials: JR
authors.lastname: Gong
mesh_terms: D006801:Humans; D057139:Nanofibers; D009369:Neoplasms / Q000473:pathology*; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D015032:Zinc
keywords: Cancer inhibition; NF-kappa B; extracellular heat shock protein; nanobiomedicine; nanofiber