title: A model-based reconstruction technique for quantitative myocardial perfusion imaging.
abstract: To reduce saturation effects in the arterial input function (AIF) estimation of quantitative myocardial first-pass saturation recovery perfusion imaging by employing a model-based reconstruction.
  
  
  
  Imaging was performed with a saturation recovery prepared radial FLASH sequence. A model-based reconstruction was applied for reconstruction. By exploiting prior knowledge about the relaxation process, an image series with different saturation recovery times was reconstructed. By evaluating images with an effective saturation time of approximately 3 ms, saturation effects in the AIF determination were reduced. In a volunteer study, this approach was compared with a standard prebolus technique.
  
  
  
  In comparison to the low-dose injection of a prebolus acquisition, saturation effects were further reduced in the AIFs determined using the model-based approach. These effects, which were clearly visible for all six volunteers, were reflected in a statistically significant difference of up to 20% in the absolute perfusion values.
  
  
  
  The application of model-based reconstruction algorithms in quantitative myocardial perfusion imaging promises a significant improvement of the AIF determination. In addition to greatly reducing saturation effects that occur even for the prebolus methods, only a single bolus has to be applied. Magn Reson Med 76:880-887, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Würzburg, Germany.|Department of Nuclear Medicine, University of Würzburg, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Tran-Gia
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Würzburg, Germany.|Comprehensive Heart Failure Center Würzburg, University of Würzburg, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Lohr
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Würzburg, Germany.
authors.forename: Andreas Max
authors.initials: AM
authors.lastname: Weng
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Würzburg, Germany.|Department of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Germany.
authors.forename: Christian Oliver
authors.initials: CO
authors.lastname: Ritter
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Würzburg, Germany.|Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Stäb
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Würzburg, Germany.
authors.forename: Thorsten Alexander
authors.initials: TA
authors.lastname: Bley
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Würzburg, Germany.|Comprehensive Heart Failure Center Würzburg, University of Würzburg, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Köstler
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics*; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006321:Heart; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008297:Male; D008955:Models, Cardiovascular; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009206:Myocardium / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: MAP reconstruction; arterial input function; model-based reconstruction; quantitative myocardial perfusion imaging; radial acquisition; saturation recovery magnetization preparation