title: [Relationship between Arsenic (+3 Oxidation State) Methyltransferase Genetic Polymorphisms and Methylation Capacity of Inorganic Arsenic].
abstract: Arsenic metabolism affects the susceptibility of humans to arsenic toxicity; therefore, clarification of the factors associated with individual variations in arsenic metabolism is an important task. Genetic polymorphisms such as single nucleotide polymorphisms (SNPs) in arsenic (+3 oxidation state) methyltransferase (AS3MT), which can methylate arsenic compounds using S-adenosyl-l-methionine (AdoMet), have been reported to modify arsenic methylation. In this review, we summarize studies conducted by us in Vietnam and by others on the association of AS3MT genetic polymorphisms with arsenic metabolism as well as human health effects. Most of the SNPs in AS3MT showed inconsistent results in terms of genotype-dependent differences in arsenic metabolism among the studies. However, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the study population: AS3MT 12390 (rs3740393) affected the second step of methylation of arsenic, whereas 14458 (rs11191439) affected the first methylation step.
authors.affiliation: Center for Marine Environmental Studies (CMES), Ehime University.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Agusa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kunito
authors.forename: Nguyen
authors.initials: N
authors.lastname: Minh Tue
authors.forename: Vi
authors.initials: V
authors.lastname: Thi Mai Lan
authors.forename: Tu
authors.initials: T
authors.lastname: Binh Minh
authors.forename: Pham
authors.initials: P
authors.lastname: Thi Kim Trang
authors.forename: Junko
authors.initials: J
authors.lastname: Fujihara
authors.forename: Haruo
authors.initials: H
authors.lastname: Takeshita
authors.forename: Shin
authors.initials: S
authors.lastname: Takahashi
authors.forename: Pham
authors.initials: P
authors.lastname: Hung Viet
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tanabe
authors.forename: Hisato
authors.initials: H
authors.lastname: Iwata
mesh_terms: D001151:Arsenic / Q000633:toxicity*; D020261:Arsenic Poisoning / Q000235:genetics*; D001152:Arsenicals / Q000378:metabolism*; D002478:Cells, Cultured; D020022:Genetic Predisposition to Disease; D005838:Genotype; D022781:Hepatocytes / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D008745:Methylation; D008780:Methyltransferases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D001749:Urinary Bladder Neoplasms / Q000201:enzymology / Q000235:genetics
chemical_list: D001152:Arsenicals; D008780:Methyltransferases; C505756:AS3MT protein, human; D001151:Arsenic