title: Comparison of IgG against plastic resin in workers with and without chemical dermatitis.
abstract: BACKGROUND
  There are many chemical sensitizers which cause allergy in the surrounding environment. However, the identification of substances causing allergy is difficult. We developed a new method to detect IgG which reacts against many kinds of chemical-human serum albumin (HSA) adducts at the same time. In this study, the diagnostic significance of the IgG was studied among workers of a company where a mass outbreak of chemical dermatitis had occurred after changing a plastic resin to a new one.
  
  
  METHODS
  Eleven workers who handled the new plastic resin and suffered from dermatitis (case) and 9 workers who also handled the same resin in the same company but were free from dermatitis (control) were the subjects. Immunological dot blotting was carried out to detect serum IgG using originally prepared diagnostic antigens, comprising a mixture of HSA and the plastic resin or its components under various conditions.
  
  
  RESULTS
  IgG against the plastic resin in use was detected in all workers who suffered from dermatitis. The prevalence of the IgG against the plastic resin was significantly higher in workers with than in those without dermatitis. On the other hand, IgG against its components (bisphenol A diglycidyl ether, m-xylylenediamine and butyl 2,3-epoxypropyl ether) was detected in a few workers with dermatitis.
  
  
  CONCLUSIONS
  This suggests that IgG against chemical-HSA adduct reflects not only exposure but also causative chemicals of dermatitis. Our method to use a material itself as a hapten is practical and useful in the occupational field.
  
  
  CONCLUSIONS
  It is suggested that IgG against chemicals is a useful marker of chemicals inducing dermatitis.
authors.affiliation: Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan. kawamott@med.uoeh-u.ac.jp.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kawamoto
authors.affiliation: Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan. tsuji@med.uoeh-u.ac.jp.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tsuji
authors.affiliation: Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan. isse@med.uoeh-u.ac.jp.
authors.forename: Toyohi
authors.initials: T
authors.lastname: Isse
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000276:immunology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000276:immunology; D004852:Epoxy Compounds / Q000009:adverse effects; D004853:Epoxy Resins / Q000009:adverse effects*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods; D010969:Plastics / Q000009:adverse effects; D014992:Xylenes / Q000009:adverse effects; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004852:Epoxy Compounds; D004853:Epoxy Resins; D007074:Immunoglobulin G; D010969:Plastics; D014992:Xylenes; C066883:1,3-xylenediamine; C019273:bisphenol A diglycidyl ether; D000098826:Bisphenol A Compounds