title: A rare avascolar osteonecrosis of the knee related to biphosphonate treatment in a patient with metastatic breast cancer.
abstract: Bisphosphonates are widely used both in the multidisciplinary management of bone metastases, especially osteolytic lesions from solid tumors or multiple myeloma, and of osteoporosis.Aseptic osteonecrosis, especially of the jaw, is among the well-known, although uncommon, side effects of bisphosphonates. Osteonecrosis of other bones has been very rarely reported with the use of bisphosphonates.We describe a rare case of osteonecrosis of the distal femur associated with the use of bisphosphonates in a 74 years old female patient with metastatic breast cancer.
authors.affiliation: Institute of Oncology of Southern Switzerland (IOSI), Lugano, Switzerland.|Breast Unit of Southern Switzerland (CSSI), Lugano, Switzerland.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Rossi
authors.affiliation: Institute of Oncology of Southern Switzerland (IOSI), Lugano, Switzerland.|Breast Unit of Southern Switzerland (CSSI), Lugano, Switzerland.
authors.forename: Simona Di
authors.initials: SD
authors.lastname: Lascio
authors.affiliation: Institute of Oncology of Southern Switzerland (IOSI), Lugano, Switzerland.
authors.forename: Michail
authors.initials: M
authors.lastname: Kouros
authors.affiliation: Institute of Oncology of Southern Switzerland (IOSI), Lugano, Switzerland.|Breast Unit of Southern Switzerland (CSSI), Lugano, Switzerland.
authors.forename: Olivia
authors.initials: O
authors.lastname: Pagani
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D001201:Ascites / Q000175:diagnosis / Q000209:etiology; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008408:Mastectomy / Q000379:methods; D009367:Neoplasm Staging; D010024:Osteoporosis / Q000188:drug therapy; D010537:Peritoneum / Q000473:pathology; D016896:Treatment Outcome; D000069584:Unilateral Breast Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: Bisphosphonates; knee osteonecrosis; metastatic breast cancer