title: Oxidative stress by Haemonchus contortus in lambs: Influence of treatment with zinc edetate.
abstract: The aim of the present study was to assess the effects of zinc edetate on the oxidative stress of lambs infected by Haemonchus contortus. Twenty-four lambs were allocated into four groups: Group I--uninfected animals; Group II--uninfected animals treated subcutaneously with zinc edetate; Group III--animals infected by H. contortus and Group IV--animals infected and treated. The oxidative stress index (OSI) and the eggs per gram of feces (EPG) were assessed after 10, 17, 24, 31 and 38 days post-infection. Based on the EPG and the quantity of adult H. contortus, the infection did not differ between groups III and IV. Zinc edetate reduced the OSI in Group IV in relation to Group I after 24 days post-infection, and in relation to group III after 31 days post-infection. Treatment with zinc edetate could help reduce the oxidative stress induced by H. contortus in lambs.
authors.affiliation: Laboratório de Endocrinologia e Metabologia Animal (LEMA), Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil. Electronic address: felipe.pivoto@gmail.com.
authors.forename: Felipe Lamberti
authors.initials: FL
authors.lastname: Pivoto
authors.affiliation: Departamento de analises clínicas e toxicológicas, Universidade Federal de Santa Maria, Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil.
authors.forename: Vanessa Dorneles
authors.initials: VD
authors.lastname: Torbitz
authors.affiliation: Laboratório de Endocrinologia e Metabologia Animal (LEMA), Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil.
authors.forename: Adelina Rodrigues
authors.initials: AR
authors.lastname: Aires
authors.affiliation: Laboratório de Endocrinologia e Metabologia Animal (LEMA), Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil.
authors.forename: José Francisco Xavier
authors.initials: JF
authors.lastname: da Rocha
authors.affiliation: Grupo de Pesquisa e Extensão em Cadeias Produtivas do Pampa (PECPAMPA), Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil.
authors.forename: Marcelo Machado
authors.initials: MM
authors.lastname: Severo
authors.affiliation: Laboratório de Endocrinologia e Metabologia Animal (LEMA), Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil.
authors.forename: Thirssa Heleno
authors.initials: TH
authors.lastname: Grando
authors.affiliation: Laboratório de Endocrinologia e Metabologia Animal (LEMA), Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil.
authors.forename: Mateus
authors.initials: M
authors.lastname: Peiter
authors.affiliation: Departamento de analises clínicas e toxicológicas, Universidade Federal de Santa Maria, Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil.
authors.forename: Rafael Noal
authors.initials: RN
authors.lastname: Moresco
authors.affiliation: Laboratório de Bioquímica e Toxicologica, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil.
authors.forename: João Batista Teixeira
authors.initials: JB
authors.lastname: da Rocha
authors.affiliation: Laboratório de Endocrinologia e Metabologia Animal (LEMA), Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil.
authors.forename: Marta Lizandra do Rego
authors.initials: ML
authors.lastname: Leal
mesh_terms: D000818:Animals; D004492:Edetic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005243:Feces / Q000469:parasitology; D005260:Female; D006188:Haemonchiasis / Q000662:veterinary*; D006189:Haemonchus; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010270:Parasite Egg Count / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000469:parasitology* / Q000473:pathology; D015032:Zinc / Q000494:pharmacology
chemical_list: D004492:Edetic Acid; D015032:Zinc
keywords: Haemonchus contortus; Oxidative stress index; Sheep; Zinc edetate