title: An expanding universe of noncoding RNAs between the poles of basic science and clinical investigations.
abstract: The Keystone Symposium 'MicroRNAs and Noncoding RNAs in Cancer', Keystone, CO, USA, 7-12 June 2015 Since the discovery of RNAi, great efforts have been undertaken to unleash the potential biomedical applicability of small noncoding RNAs, mainly miRNAs, involving their use as biomarkers for personalized diagnostics or their usability as active agents or therapy targets. The research's focus on the noncoding RNA world is now slowly moving from a phase of basic discoveries into a new phase, where every single molecule out of many hundreds of cataloged noncoding RNAs becomes dissected in order to investigate these molecules' biomedical relevance. In addition, RNA classes neglected before, such as long noncoding RNAs or circular RNAs attract more attention. Numerous timely results and hypotheses were presented at the 2015 Keystone Symposium 'MicroRNAs and Noncoding RNAs in Cancer'.
authors.affiliation: HELIOS Medical Centre Wuppertal, Centre for Clinical & Translational Research (CCTR), Faculty of Health, Centre for Biomedical Education & Research (ZBAF), Witten/Herdecke University, Heusnerstr. 40, 42283 Wuppertal, Germany.
authors.forename: Patrick P
authors.initials: PP
authors.lastname: Weil
authors.affiliation: HELIOS Medical Centre Wuppertal, Centre for Clinical & Translational Research (CCTR), Faculty of Health, Centre for Biomedical Education & Research (ZBAF), Witten/Herdecke University, Heusnerstr. 40, 42283 Wuppertal, Germany.
authors.forename: Kai O
authors.initials: KO
authors.lastname: Hensel
authors.affiliation: HELIOS Medical Centre Wuppertal, Centre for Clinical & Translational Research (CCTR), Faculty of Health, Centre for Biomedical Education & Research (ZBAF), Witten/Herdecke University, Heusnerstr. 40, 42283 Wuppertal, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Weber
authors.affiliation: HELIOS Medical Centre Wuppertal, Centre for Clinical & Translational Research (CCTR), Faculty of Health, Centre for Biomedical Education & Research (ZBAF), Witten/Herdecke University, Heusnerstr. 40, 42283 Wuppertal, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Postberg
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D009374:Neoplasms, Experimental / Q000235:genetics; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C077885:XIST non-coding RNA
keywords: RNA interference; biomarkers; cancer; long noncoding RNA; microRNA; noncoding RNA