title: Biomimetic Scaffolds for Osteogenesis.
abstract: Skeletal regenerative medicine emerged as a field of investigation to address large osseous deficiencies secondary to congenital, traumatic, and post-oncologic conditions. Although autologous bone grafts have been the gold standard for reconstruction of skeletal defects, donor site morbidity remains a significant limitation. To address these limitations, contemporary bone tissue engineering research aims to target delivery of osteogenic cells and growth factors in a defined three dimensional space using scaffolding material. Using bone as a template, biomimetic strategies in scaffold engineering unite organic and inorganic components in an optimal configuration to both support osteoinduction as well as osteoconduction. This article reviews the various structural and functional considerations behind the development of effective biomimetic scaffolds for osteogenesis and highlights strategies for enhancing osteogenesis.
authors.affiliation: Division of Plastic and Reconstructive Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA 90095 ; Division of Plastic and Reconstructive Surgery, Greater Los Angeles VA Healthcare System, Los Angeles, CA 90073.
authors.forename: Nance
authors.initials: N
authors.lastname: Yuan
authors.affiliation: Division of Plastic and Reconstructive Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA 90095 ; Division of Plastic and Reconstructive Surgery, Greater Los Angeles VA Healthcare System, Los Angeles, CA 90073.
authors.forename: Kameron S
authors.initials: KS
authors.lastname: Rezzadeh
authors.affiliation: Division of Plastic and Reconstructive Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA 90095 ; Division of Plastic and Reconstructive Surgery, Greater Los Angeles VA Healthcare System, Los Angeles, CA 90073.
authors.forename: Justine C
authors.initials: JC
authors.lastname: Lee
keywords: Osteogenesis; biomimetic; bone tissue engineering; scaffolds