title: Relationship between non-suspicious MRI and insignificant prostate cancer: results from a monocentric study.
abstract: OBJECTIVE
  To assess whether non-suspicious multiparametric magnetic-resonance imaging (mpMRI) was associated with no cancer or indolent prostate cancer (PCa) in subsequent biopsies.
  
  
  METHODS
  Retrospective analyses of a prospective database were conducted between 2009 and 2013. It included men with an abnormal digital rectal examination and/or prostate-specific antigen levels <20 ng/mL and a non-suspicious multiparametric MRI (Likert score <3). Participants underwent a systematic 12-extended-core biopsy ultrasound protocol (STD). Indolent PCa was defined as a single core with a Gleason score of 6 (3 + 3) and a cancer-core length of ≤4 mm.
  
  
  RESULTS
  Seventy-eight patients with a negative MRI were included in the study; median patient age was 62 years (IQR 50-74). Median PSA level was 7.15 ng/mL, with a median PSA density of 0.15. The digital rectal examination was abnormal in eight cases. From MRI, 53 patients were Likert 2, 25 patients were Likert 1, and median prostate volume was 56.5 mL. From biopsies, no cancer was found in 92.3 % (n = 72). PCa was histologically confirmed in six patients (7.7 %): five cases were indolent (as defined above); only one patient had a cancer core of 5 mm long, with a Gleason score of 6 (3 + 3). All six patients were within the low-risk group according to the D'Amico classification.
  
  
  CONCLUSIONS
  Men with non-suspicious mpMRI are likely to have no or indolent PCa in subsequent biopsies.
authors.affiliation: Academic Department of Radiology, AP-HP, Hopital Pitié-Salpétrière, 83 Bvd Hôpital, 75013, Paris, France. raphaele.renardpenna@psl.aphp.fr.|GRC5, ONCOTYPE-Uro, Institut Universitaire de Cancérologie, UPMC Univ Paris 06, 75005, Paris, France. raphaele.renardpenna@psl.aphp.fr.
authors.forename: Raphaële
authors.initials: R
authors.lastname: Renard-Penna
authors.affiliation: Academic Department of Urology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France.|GRC5, ONCOTYPE-Uro, Institut Universitaire de Cancérologie, UPMC Univ Paris 06, 75005, Paris, France.
authors.forename: Morgan
authors.initials: M
authors.lastname: Roupret
authors.affiliation: Academic Department of Pathology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France.|GRC5, ONCOTYPE-Uro, Institut Universitaire de Cancérologie, UPMC Univ Paris 06, 75005, Paris, France.
authors.forename: Eva
authors.initials: E
authors.lastname: Compérat
authors.affiliation: Urology Department, Montsouris Institute, 75014, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Rozet
authors.affiliation: Academic Department of Biostatistics, Public Health and Medical Information, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Granger
authors.affiliation: Academic Department of Urology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France.
authors.forename: Johann
authors.initials: J
authors.lastname: Barkatz
authors.affiliation: Academic Department of Urology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France.
authors.forename: Marc Olivier
authors.initials: MO
authors.lastname: Bitker
authors.affiliation: Academic Department of Radiology, AP-HP, Hopital Pitié-Salpétrière, 83 Bvd Hôpital, 75013, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lucidarme
authors.affiliation: Academic Department of Urology, AP-HP, Hopital Tenon, 75020, Paris, France.|GRC5, ONCOTYPE-Uro, Institut Universitaire de Cancérologie, UPMC Univ Paris 06, 75005, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Cussenot
authors.affiliation: Academic Department of Urology, AP-HP, Hopital Pitié-Salpétrière, 75013, Paris, France.|GRC5, ONCOTYPE-Uro, Institut Universitaire de Cancérologie, UPMC Univ Paris 06, 75005, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Mozer
mesh_terms: D000368:Aged; D001706:Biopsy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D012189:Retrospective Studies
keywords: Biopsy; Gleason score; MRI; Prostate neoplasms; Prostate-specific antigen