title: The impact of follicular fluid adiponectin and ghrelin levels based on BMI on IVF outcomes in PCOS.
abstract: OBJECTIVE
  This study aimed at evaluating the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on follicular fluid (FF) adiponectin and ghrelin levels, and on in vitro fertilization outcomes in patients who underwent controlled ovarian hyperstimulation.
  
  
  METHODS
  This prospective cross-sectional study was performed with a total of 120 primary infertile women [group 1; non-PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30) and group 2; PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30)]. On the day of oocyte pickup, FF samples were collected.
  
  
  RESULTS
  The FF adiponectin levels were lower in the lean PCOS group than the lean non-PCOS group (p = 0.001), and these levels were lower in the overweight non-PCOS group compared to lean non-PCOS group (0.001). However, there was no difference in the FF ghrelin levels between the groups. Additionally, we could not find a relationship between clinical pregnancy and adiponectin and ghrelin levels.
  
  
  CONCLUSIONS
  The FF adiponectin and ghrelin levels have no effects on clinical pregnancy in PCOS. Therefore, further studies are needed to elucidate this issue.
authors.affiliation: Konya Education and Research Hospital, Konya, Turkey. dr.hasanaliinal@yahoo.com.
authors.forename: H A
authors.initials: HA
authors.lastname: Inal
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Yilmaz
authors.affiliation: Medical Faculty, Hitit University, Corum, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Gorkem
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey.
authors.forename: A S
authors.initials: AS
authors.lastname: Oruc
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Timur
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism*; D005500:Follow-Up Studies; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000628:therapy; D006080:Ovarian Follicle / Q000254:growth & development*; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology* / Q000378:metabolism; D011247:Pregnancy; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D014421:Turkey / Q000453:epidemiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D054439:Ghrelin
keywords: ART; Adiponectin; Ghrelin; IVF outcomes; Polycystic ovary syndrome