title: Clinical Outcome Measures in Chiari I Malformation.
abstract: Chiari malformation type 1 (CM-I) is a common and often debilitating neurologic disease. Reliable evaluation of treatments has been hampered by inconsistent use of clinical outcome measures. A variety of outcome measurement tools are available, although few have been validated in CM-I. The recent development of the Chicago Chiari Outcome Scale and the Chiari Symptom Profile provides CM-I-specific instruments to measure outcomes in adults and children, although validation and refinement may be necessary.
authors.affiliation: Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8057, St. Louis, MO 63110, USA. Electronic address: yarbroughc@wustl.edu.
authors.forename: Chester K
authors.initials: CK
authors.lastname: Yarbrough
authors.affiliation: Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8057, St. Louis, MO 63110, USA.
authors.forename: Jacob K
authors.initials: JK
authors.lastname: Greenberg
authors.affiliation: Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8057, St. Louis, MO 63110, USA; Department of Neurological Surgery, St Louis Children's Hospital, Suite 4S20, St Louis, MO 63110, USA.
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
mesh_terms: D001139:Arnold-Chiari Malformation / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D015588:Observer Variation; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications / Q000175:diagnosis* / Q000628:therapy; D011237:Predictive Value of Tests; D015203:Reproducibility of Results
keywords: Chiari malformation type 1; Clinical research; Outcome instruments; Outcome methods; Quality of life; Treatment outcome