title: Nutrition and the science of disease prevention: a systems approach to support metabolic health.
abstract: Progress in nutritional science, genetics, computer science, and behavioral economics can be leveraged to address the challenge of noncommunicable disease. This report highlights the connection between nutrition and the complex science of preventing disease and discusses the promotion of optimal metabolic health, building on input from several complementary disciplines. The discussion focuses on (1) the basic science of optimal metabolic health, including data from gene-diet interactions, microbiome, and epidemiological research in nutrition, with the goal of defining better targets and interventions, and (2) how nutrition, from pharma to lifestyle, can build on systems science to address complex issues.
authors.affiliation: Departments of Genetics and Nutrition, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Bennett
authors.affiliation: Integrative Physiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Hall
authors.affiliation: Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.affiliation: Food and Nutritional Sciences, University of Reading, Reading, United Kingdom.
authors.forename: Anne L
authors.initials: AL
authors.lastname: McCartney
authors.affiliation: Departments of Social and Behavioral Sciences and Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
authors.forename: Christina
authors.initials: C
authors.lastname: Roberto
mesh_terms: D000818:Animals; D059647:Gene-Environment Interaction; D006801:Humans; D008019:Life Style; D008659:Metabolic Diseases / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control; D064307:Microbiota; D052756:Nutritional Sciences / Q000379:methods
keywords: body weight; diabetes; gene-diet interactions; gut microbiome; obesity; systems science