title: [SOME RESULTS OF MOLECULAR GENETIC RESEARCHES OF AGING AND LONGEVITY].
abstract: This review is devoted to the description of research achievements in genetics of aging and longevity. It represents a certain interest for understanding of a problems of aging as a whole. There is a huge amount of results of diverse genetic studies of aging and longevity. Studies were performed with using different experimental strategies on model organisms or samples from different human populations of the world. The search for aging and longevity genes was carried out within international consortiums. The first results of whole genome sequences of super-centenarians were received. The genes influencing life expectancy were revealed in organisms of different systematic groups. Many of these genes are evolutionarily conservative. Associations between APOE, FOXO1A, FOXO3A, AKT1 gene polymorphisms and human longevity were confirmed in independent studies.
authors.forename: O E
authors.initials: OE
authors.lastname: Mustafina
authors.forename: R Sh
authors.initials: RSh
authors.lastname: Somova
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000235:genetics*; D008967:Molecular Biology / Q000379:methods*