title: Liver transplantation for nonalcoholic steatohepatitis in young patients.
abstract: Nonalcoholic steatohepatitis (NASH) is the hepatic manifestation of obesity and insulin resistance. The aim of this study was to determine the frequency of NASH as an indication for liver transplantation (LT) in children and young adults and to characterize patient and graft survival. The study included all children and young adult patients (up to the age of 40 years) who underwent LT in the United States for NASH cirrhosis from the 1987 to 2012 United Network for Organ Sharing (UNOS) database. Kaplan-Meier analysis was used to assess patient and graft survival. A total of 330 patients were included, 68% were Caucasian, and the mean BMI was 33.6 ± 6.3. Age at time of LT ranged between 4 and 40 years (mean 33.9 ± 6.6 years). Fourteen subjects were <18 years of age at time of LT and 20 were between the ages of 18 and 25 years. Median follow-up after 1st LT was 45.8 months [10.7, 97.3]. During this time, 30% of subjects (n = 100) died and 11.5% (n = 38) were retransplanted including 13 for NASH recurrence. In conclusion, NASH can progress to end-stage liver disease requiring LT in childhood and early adulthood. A significant number of young patients transplanted for NASH cirrhosis required retransplantation.
authors.affiliation: Department of Gastroenterology and Hepatology and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Naim
authors.initials: N
authors.lastname: Alkhouri
authors.affiliation: Department of Gastroenterology and Hepatology and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Ibrahim A
authors.initials: IA
authors.lastname: Hanouneh
authors.affiliation: Department of Gastroenterology and Hepatology and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Nizar N
authors.initials: NN
authors.lastname: Zein
authors.affiliation: Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Rocio
authors.initials: R
authors.lastname: Lopez
authors.affiliation: Department of Gastroenterology and Hepatology and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Dympna
authors.initials: D
authors.lastname: Kelly
authors.affiliation: Department of Gastroenterology and Hepatology and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Bijan
authors.initials: B
authors.lastname: Eghtesad
authors.affiliation: Department of Gastroenterology and Hepatology and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Fung
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016208:Databases, Factual; D018450:Disease Progression; D058625:End Stage Liver Disease / Q000401:mortality / Q000601:surgery; D005260:Female; D006085:Graft Survival; D006801:Humans; D007333:Insulin Resistance; D053208:Kaplan-Meier Estimate; D016031:Liver Transplantation; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000401:mortality / Q000601:surgery*; D009765:Obesity / Q000150:complications; D016896:Treatment Outcome; D055815:Young Adult
keywords: children; cryptogenic cirrhosis; liver transplantation; nonalcoholic steatohepatitis; young adults