title: Primary breast tuberculosis: diagnostic and therapeutic dilemmas.
abstract: OBJECTIVE
  To review the diagnostic and therapeutic challenges associated with treating isolated primary breast tuberculosis through discussion of our series of seven cases.
  
  
  BACKGROUND
  Although breast is an uncommon site of occurrence of tuberculosis and isolated primary breast tuberculosis is an even rarer entity, its importance lies in distinguishing it from more common pathologies like abscesses or malignancy and avoiding unnecessary erroneous surgical intervention. The spectrum and presentation is wide and varied and we present our experience in managing seven such cases.
  
  
  METHODS
  A retrospective analysis of all the cases of histopathologically proven primary breast tuberculosis in the last three years at M.S. Ramaiah Hospital (2012-2014) was done. Analysis was in terms of mode of presentation, clinical features, diagnostic modalities used for evaluation and confirmation of the diagnosis, medical treatment and surgical intervention, if any. Special emphasis was placed on dilemmas in diagnosis and difficulties encountered during treatment. All cases were followed up till cure.
  
  
  RESULTS
  Patients most commonly presented with a breast abscess, painful breast lumps and recurrent abscesses. Other foci of tuberculosis were ruled out in all of these patients. Majority were treated exclusively with anti-tubercular therapy (although regimens varied), but those with abscesses underwent incision and drainage. All cases were treated and followed up till cure.
  
  
  CONCLUSIONS
  The challenges associated with primary breast tuberculosis are multiple, including which anti-tubercular therapy regimen to use, when to surgically intervene (as the breast is a cosmetically important area) and treating atypical mycobacteria. We provide a detailed discussion of the challenges we faced and review of literature.
authors.forename: Bharati V
authors.initials: BV
authors.lastname: Hiremath
authors.forename: Narayana
authors.initials: N
authors.lastname: Subramaniam
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage*; D001707:Biopsy, Needle / Q000379:methods; D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D001943:Breast Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004322:Drainage / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009161:Mycobacterium / Q000187:drug effects / Q000302:isolation & purification; D012008:Recurrence; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D014376:Tuberculosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D016217:Ultrasonography, Mammary
chemical_list: D000995:Antitubercular Agents
keywords: Primary breast tuberculosis