title: Factors Affecting the Development of Diabetes Mellitus After Pancreatic Resection.
abstract: OBJECTIVE
  Glucose homeostasis changes after pancreatic resection are not well understood. We aimed to identify the incidence of, and risk factors for, a change in glucose homeostasis in patients who underwent pancreatectomy for benign pancreatic tumors.
  
  
  METHODS
  Clinical and pathological data from 229 patients were collected prospectively and analyzed retrospectively. The pancreas resection volume was calculated by computed tomography volumetry.
  
  
  RESULTS
  After pancreatectomy, newly diagnosed diabetes mellitus (DM) occurred in 52 patients (22.7%) and impaired fasting glucose and impaired glucose tolerance occurred in 74 patients (32.3%). The incidence of DM was highest for patients who underwent distal pancreatectomy (DP) (30.5%). Patients in the DP group had a significantly increased rate of DM as the pancreatic resection volume (in milliliters) and resected volume ratio (in percent) increased. A high body mass index and older age were significant risk factors for the development of DM by multivariate analysis.
  
  
  CONCLUSIONS
  The resection volume of the pancreas is associated with a change in glucose homeostasis after pancreatectomy. Therefore, preservation of the pancreatic parenchyma is important to minimize the onset of DM in patients with a high pancreatic resected volume ratio (>35.6%) in DP, a high body mass index, or in old age.
authors.affiliation: From the *Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center; and †Asan Institute for Life Science, Songpa-gu, Seoul, Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Kwon
authors.forename: Song Cheol
authors.initials: SC
authors.lastname: Kim
authors.forename: In Kyong
authors.initials: IK
authors.lastname: Shim
authors.forename: Ki Byung
authors.initials: KB
authors.lastname: Song
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Dae Wook
authors.initials: DW
authors.lastname: Hwang
authors.forename: Kwang-Min
authors.initials: KM
authors.lastname: Park
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D005215:Fasting / Q000097:blood; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010179:Pancreas / Q000473:pathology / Q000601:surgery*; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D001786:Blood Glucose