title: Partial effects of the AMPAkine CX717 in a strain specific battery of tests for manic-like behavior in black Swiss mice.
abstract: BACKGROUND
  AMPA receptors are highly expressed throughout the central nervous system and are suggested to be involved in mood regulation. Studies found changes in glutamate, its metabolites and receptors in patients with bipolar disorder (BPD) or major depression (MD) and in animal models of stress. Additional data suggest that the glutamatergic system and AMPA receptors specifically, have an important role in modulating the therapeutic effects of mood stabilizers. Further research on the role of AMPA receptors in mood regulation can be done using AMPAkines, positive modulators of AMPA receptors. AMPAkines have been studied for cognitive enhancement in neurodegenerative disorders and some were also examined in preclinical studies of mood disorders. In that context, the present study was designed to test the effects of the AMPAkine CX717 in a strain specific battery of tests for mania-like behaviors.
  
  
  METHODS
  Black Swiss male mice were sub-chronically treated with 5 different doses of CX717 or vehicle and tested in a battery of behavioral tests including spontaneous activity, sweet solution preference, resident-intruder, forced swim and amphetamine-induced hyperactivity.
  
  
  RESULTS
  Data show that CX717 doses of 30mg/kg and above, but not lower, reduce activity levels. Moreover, 45mg/kg and above reduce interactions in the resident-intruder test and ameliorate amphetamine-induced hyperactivity.
  
  
  CONCLUSIONS
  The results therefore show a partial effect of CX717 on manic-like behavior, somewhat similar to previously demonstrated effects of atypical antipsychotic drugs in this strain. It is therefore suggested that further work related to AMPAkines in the treatment of affective disorders might be warranted.
authors.affiliation: School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel-Aviv, Israel; Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beersheba, Israel.
authors.forename: Nirit Z
authors.initials: NZ
authors.lastname: Kara
authors.affiliation: Department of Psychology, Winona State University, Winona, USA.
authors.forename: Shlomit
authors.initials: S
authors.lastname: Flaisher-Grinberg
authors.affiliation: School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel-Aviv, Israel; Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beersheba, Israel; College of Pharmacy, University of Minnesota, Duluth, USA. Electronic address: haimh@mta.ac.il.
authors.forename: Haim
authors.initials: H
authors.lastname: Einat
mesh_terms: D000374:Aggression / Q000187:drug effects; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D018692:Antimanic Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects*; D001714:Bipolar Disorder / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007555:Isoxazoles / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D018091:Receptors, AMPA / Q000187:drug effects; D013550:Swimming / Q000523:psychology
chemical_list: D018692:Antimanic Agents; C542518:CX717; D000697:Central Nervous System Stimulants; D007555:Isoxazoles; D018091:Receptors, AMPA; D000661:Amphetamine
keywords: AMPA receptors; Affective disorders; Animal model; Behavior; Mania