title: Down-regulation of AKT combined with radiation-induced autophagy and apoptosis roles in MCF-7 cells.
abstract: Autophagy is an evolutionarily conservation process whereby cytoplasm and cellular organelles are degraded in lysosomes for amino acid and energy recycling. Autophagy concurrent with radiotherapy has emerged as a novel approach in breast cancer treatment. Our studies conclude that autophagy and apoptosis can be induced by radiation and inhibition of autophagy can increase apoptosis. In addition, Akt is a molecule that down-regulates autophagy and apoptosis; blocking Akt can enhance autophagy and apoptosis induced by radiation in MCF-7 cells. Akt could become a new focus in breast cancer radiotherapy.
authors.affiliation: Department of Epidemiology, School of Public Health, Beihua University, Jilin 132011, Jilin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Jilin Entry-exit Inspection and Quarantine, Jilin 132011, Jilin, China.
authors.forename: Dali
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Jilin Entry-exit Inspection and Quarantine, Jilin 132011, Jilin, China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Department of Epidemiology, School of Public Health, Beihua University, Jilin 132011, Jilin, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Qi
mesh_terms: D017209:Apoptosis / Q000528:radiation effects*; D001343:Autophagy / Q000528:radiation effects*; D001940:Breast / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy; D003131:Combined Modality Therapy; D015536:Down-Regulation; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D000067492:RNAi Therapeutics
chemical_list: D012333:RNA, Messenger; D051057:Proto-Oncogene Proteins c-akt
keywords: Akt; Autophagy; apoptosis; breast cancer; radiation