title: Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH).
abstract: Platensimycin and platencin were successively discovered from the strain Streptomyces platensis through systematic screening. These natural products have been defined as promising agents for fighting multidrug resistance in bacteria by targeting type II fatty acid synthesis with slightly different mechanisms. Bioactivity studies have shown that platensimycin and platencin offer great potential to inhibit many resistant bacteria with no cross-resistance or toxicity observed in vivo. This review summarizes the general information on platensimycin and platencin, including antibacterial and self-resistant mechanisms. Furthermore, the total synthesis pathways of platensimycin and platencin and their analogues from recent studies are presented.
authors.affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China. shangrf1974@163.com.
authors.forename: Ruofeng
authors.initials: R
authors.lastname: Shang
authors.affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China. liangjianping@caas.cn.
authors.forename: Jianping
authors.initials: J
authors.lastname: Liang
authors.affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China. yiyunpeng88@163.com.
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China. yangguang8684@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China. Wang_jiatu@sina.com.
authors.forename: Jiatu
authors.initials: J
authors.lastname: Wang
mesh_terms: D000218:Adamantane / Q000737:chemistry / Q000494:pharmacology*; D062365:Aminobenzoates / Q000737:chemistry / Q000494:pharmacology*; D000627:Aminophenols / Q000737:chemistry / Q000494:pharmacology*; D000813:Anilides / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D054889:Fatty Acid Synthase, Type II / Q000037:antagonists & inhibitors; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry
chemical_list: D062365:Aminobenzoates; D000627:Aminophenols; D000813:Anilides; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D011083:Polycyclic Compounds; D054889:Fatty Acid Synthase, Type II; D000218:Adamantane; C510909:platensimycin; C520340:platencin
keywords: analogues; antibacterial activities; drug resistance; platencin; platensimycin; synthesis