title: PRC1 proteins orchestrate three-dimensional genome architecture.
abstract: The three-dimensional organization of the genome has an important role in orchestrating gene expression, but its regulation is poorly understood. Now, a new study uncovers a major role for Polycomb components of the PRC1 complex in organizing physical networks of genes that are co-repressed to maintain pluripotency.
authors.affiliation: Institute of Human Genetics, UPR 1142, CNRS, Montpellier, France.
authors.forename: Giacomo
authors.identifier: http://orcid.org/0000-0003-3709-3469
authors.initials: G
authors.lastname: Cavalli
mesh_terms: D000818:Animals; D053595:Embryonic Stem Cells / Q000378:metabolism*; D016678:Genome; D063146:Polycomb-Group Proteins / Q000502:physiology*
chemical_list: D063146:Polycomb-Group Proteins