title: The advancement of human pluripotent stem cell-derived therapies into the clinic.
abstract: Human pluripotent stem cells (hPSCs) offer many potential applications for drug screening and 'disease in a dish' assay capabilities. However, a more ambitious goal is to develop cell therapeutics using hPSCs to generate and replace somatic cells that are lost as a result of disease or injury. This Spotlight article will describe the state of progress of some of the hPSC-derived therapeutics that offer the most promise for clinical use. Lessons from developmental biology have been instrumental in identifying signaling molecules that can guide these differentiation processes in vitro, and will be described in the context of these cell therapy programs.
authors.affiliation: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA Department of Pathology, University of Washington, Seattle, WA 98195, USA.
authors.forename: R Scott
authors.initials: RS
authors.lastname: Thies
authors.affiliation: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA Department of Pathology, University of Washington, Seattle, WA 98195, USA Department of Bioengineering, University of Washington, Seattle, WA 98195, USA Department of Medicine/Cardiology, University of Washington, Seattle, WA 98195, USA murry@uw.edu.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Murry
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods* / Q000639:trends*; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D033161:Government Regulation; D006333:Heart Failure; D006801:Humans; D010300:Parkinson Disease / Q000628:therapy; D039904:Pluripotent Stem Cells / Q000637:transplantation*; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends*; D012162:Retinal Degeneration / Q000628:therapy; D015398:Signal Transduction / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000628:therapy
keywords: Clinical medicine; HPSC-cardiomyocytes; Human Pluripotent Stem Cell