title: Association between uric acid, cancer incidence and mortality in patients with type 2 diabetes: Shanghai diabetes registry study.
abstract: BACKGROUND
  An elevated serum uric acid level has often been observed with type 2 diabetes or cancer progression. This study aimed to investigate the association between the serum uric acid, cancer incidence, and mortality in Chinese patients with type 2 diabetes.
  
  
  METHODS
  A total of 8274 patients with type 2 diabetes from the Shanghai Diabetes Registry (SDR) participated. The follow-up rate was 85.4%. All subjects were divided into four groups according to the serum uric acid concentration: group 1 (1.0 mg/dL ≤ SUA < 3.0 mg/dL), group 2 (3.0 mg/dL ≤ SUA <5.0 mg/dL), group 3 (5.0 mg/dL ≤ SUA < 7.0 mg/dL), and group 4 (SUA ≥ 7.0 mg/dL). The primary outcome was the first diagnosis of any cancer. The secondary outcome was all-cause mortality. A Cox proportional hazards model was used to estimate the relative risks of cancer and death.
  
  
  RESULTS
  One hundred thirty-seven men and 115 women had cancer by the end of the study. In women, group 1 had the lowest incidence rate of cancer at 30.3 cases per 10 000 person-years, followed by group 2 (48.2). The cancer incidence rates in groups 3 (80.4) and 4 (100.8) were significantly higher than in group 2 (p < 0.05). No significant differences were observed in the incidence of cancer in men (p = 0.76). The risks of overall mortality and death from cancer were not significantly different among the different serum uric acid groups in either sex (Pmale = 0.480, Pfemale = 0.075).
  
  
  CONCLUSIONS
  In Chinese female diabetic patients, the incidence of cancer increased with serum uric acid levels.
authors.affiliation: Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Zixuan
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
authors.forename: Yunjuan
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Xuhong
authors.initials: X
authors.lastname: Hou
authors.affiliation: Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.affiliation: Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000401:mortality; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends*; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D011379:Prognosis; D012042:Registries; D012307:Risk Factors; D015996:Survival Rate; D014527:Uric Acid / Q000378:metabolism
chemical_list: D014527:Uric Acid
keywords: Chinese population; cancer; type 2 diabetes; uric acid