title: Long-term impact of puerperal metritis on the profiles of peripheral blood leukocytes in peripartum dairy cows.
abstract: To determine the effects of puerperal metritis on the immune response, changes in the differential peripheral blood leukocyte counts were analyzed during the peripartum period in cows with or without metritis. Multiparous Holstein cows were examined for uterine health disorders and classified into two groups: healthy (n = 11) or metritis (n = 5) cows. The lymphocyte and monocyte counts and the proportion of CD8(+) lymphocytes were higher in cows with metritis compared to healthy cows. Moreover, the effects of puerperal metritis on the lymphocyte counts and CD4(+)/CD8(+) ratio persisted weeks after the uterine inflammation had self-resolved. Taken together, the findings of the present study indicate the possible long-term alterations of systemic immune responses in cows with puerperal uterine inflammation.
authors.affiliation: Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
authors.forename: Fumie
authors.initials: F
authors.lastname: Magata
authors.affiliation: Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kitaoka
authors.affiliation: Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
authors.forename: Ikumi
authors.initials: I
authors.lastname: Morino
authors.affiliation: Nippon Beet Sugar Manufacturing Co., Ltd., Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Teramura
authors.affiliation: Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
authors.forename: Chiho
authors.initials: C
authors.lastname: Kawashima
authors.affiliation: Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Haneda
authors.affiliation: Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000276:immunology*; D004716:Endometritis / Q000097:blood / Q000276:immunology* / Q000662:veterinary*; D005260:Female; D007958:Leukocyte Count; D058725:Peripartum Period / Q000097:blood / Q000276:immunology*; D011645:Puerperal Infection / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D013997:Time Factors
keywords: dairy cow; leukocytes; metritis; peripartum