title: Biological and mechanical properties of an experimental glass-ionomer cement modified by partial replacement of CaO with MgO or ZnO.
abstract: Some weaknesses of conventional glass ionomer cement (GIC) as dental materials, for instance the lack of bioactive potential and poor mechanical properties, remain unsolved.Objective The purpose of this study was to investigate the effects of the partial replacement of CaO with MgO or ZnO on the mechanical and biological properties of the experimental glass ionomer cements.Material and Methods Calcium fluoro-alumino-silicate glass was prepared for an experimental glass ionomer cement by melt quenching technique. The glass composition was modified by partial replacement (10 mol%) of CaO with MgO or ZnO. Net setting time, compressive and flexural properties, and in vitrorat dental pulp stem cells (rDPSCs) viability were examined for the prepared GICs and compared to a commercial GIC.Results The experimental GICs set more slowly than the commercial product, but their extended setting times are still within the maximum limit (8 min) specified in ISO 9917-1. Compressive strength of the experimental GIC was not increased by the partial substitution of CaO with either MgO or ZnO, but was comparable to the commercial control. For flexural properties, although there was no significance between the base and the modified glass, all prepared GICs marked a statistically higher flexural strength (p<0.05) and comparable modulus to control. The modified cements showed increased cell viability for rDPSCs.Conclusions The experimental GICs modified with MgO or ZnO can be considered bioactive dental materials.
authors.affiliation: Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Chungnam, KR.
authors.forename: Dong-Ae
authors.initials: DA
authors.lastname: Kim
authors.affiliation: Glass Research Department, National Research Centre, Dokki, Cairo, EG.
authors.forename: Hany
authors.initials: H
authors.lastname: Abo-Mosallam
authors.affiliation: Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, Chungnam, KR.
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, Chungnam, KR.
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Chungnam, KR.
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Chungnam, KR.
authors.forename: Hae-Hyoung
authors.initials: HH
authors.lastname: Lee
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry; D000818:Animals; D017610:Calcium Compounds / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D019245:Compressive Strength; D003782:Dental Pulp; D005459:Fluorides / Q000737:chemistry; D005899:Glass Ionomer Cements / Q000737:chemistry*; D008277:Magnesium Oxide / Q000737:chemistry*; D008297:Male; D008422:Materials Testing; D010087:Oxides / Q000737:chemistry*; D018583:Pliability; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D017655:Silicon Compounds / Q000737:chemistry; D013234:Stem Cells / Q000187:drug effects; D013997:Time Factors; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D005899:Glass Ionomer Cements; D010087:Oxides; D017655:Silicon Compounds; D008277:Magnesium Oxide; C016538:lime; C020328:fluoroaluminum silicate; D005459:Fluorides; D015034:Zinc Oxide