title: High CA-125 and CA19-9 levels in spontaneous ruptured ovarian endometriomas.
abstract: BACKGROUND
  To evaluate the clinical significance of serum CA-125 and CA19-9 in women with spontaneous ruptured ovarian endometriomas.
  
  
  METHODS
  From January 2006 to April 2015, a total of 1653 women were diagnosed with ovarian endometriomas, and 43 women were diagnosed with the spontaneous rupture of their ovarian endometrioma. In addition, 70 women diagnosed with unruptured ovarian endometriomas were chosen to serve as control subjects. Serum CA-125 and CA19-9 levels, together with the clinical materials, were collected.
  
  
  RESULTS
  Serum CA-125, CA19-9, and the combined biomarkers were shown to be obviously elevated in the spontaneous ruptured ovarian endometrioma group (p=0.001, p=0.001, p=0.001, respectively). The AUC value for the combined biomarkers was 0.992 (95% CI, 0.981-1.000), with a high sensitivity and specificity of nearly 100% and 93.6%, respectively. Moreover, the maximum diameter of the mass was significantly (p=0.001) increased in the ruptured group.
  
  
  CONCLUSIONS
  Serum CA-125 and CA19-9 were significantly increased in patients with spontaneous ruptured ovarian endometriomas. Moreover, the combined biomarkers were better than either CA-125 or CA19-9 alone in the diagnosis of a spontaneous rupture of the ovarian endometrioma.
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Dai
authors.affiliation: The Department of Information and Engineering, Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Chu
authors.initials: C
authors.lastname: Jin
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Yan
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhu
authors.affiliation: The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China. Electronic address: 234898067@qq.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
mesh_terms: D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D018394:CA-125 Antigen / Q000097:blood*; D004715:Endometriosis / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D009504:Neutrophils / Q000166:cytology; D010048:Ovarian Cysts / Q000150:complications; D010049:Ovarian Diseases / Q000097:blood* / Q000150:complications; D012372:ROC Curve; D012422:Rupture, Spontaneous / Q000097:blood / Q000150:complications; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: C097353:AFP protein, human; D015295:Antigens, Tumor-Associated, Carbohydrate; D018394:CA-125 Antigen; D000509:alpha-Fetoproteins; C578959:carbohydrate antigen 199, human; D002097:C-Reactive Protein
keywords: CA-125; CA19-9; Ovarian endometrioma; Spontaneous rupture