title: Predictors of Hypomania During Ventral Capsule/Ventral Striatum Deep Brain Stimulation.
abstract: Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact. It was more common with right monopolar stimulation. These findings may help to establish decision rules to reduce complications of VC/VS DBS.
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Alik S
authors.initials: AS
authors.lastname: Widge
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Ernesto
authors.initials: E
authors.lastname: Licon
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Samuel
authors.initials: S
authors.lastname: Zorowitz
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Andrew
authors.initials: A
authors.lastname: Corse
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Amanda R
authors.initials: AR
authors.lastname: Arulpragasam
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Joan A
authors.initials: JA
authors.lastname: Camprodon
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Cristina
authors.initials: C
authors.lastname: Cusin
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Emad N
authors.initials: EN
authors.lastname: Eskandar
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Thilo
authors.initials: T
authors.lastname: Deckersbach
authors.affiliation: From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
authors.forename: Darin D
authors.initials: DD
authors.lastname: Dougherty
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000209:etiology* / Q000523:psychology; D046690:Deep Brain Stimulation / Q000009:adverse effects* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D066328:Ventral Striatum / Q000502:physiology*; D055815:Young Adult