title: Knee cartilage defect: marrow stimulating techniques.
abstract: Painful chondral defects of the knee are very difficult problems. The incidence of these lesions in the general population is not known since there is likely a high rate of asymptomatic lesions. The rate of lesions found during arthroscopic exam is highly variable, with reports ranging from 11 to 72 % Aroen (Aroen Am J Sports Med 32: 211-5, 2004); Curl(Arthroscopy13: 456-60, 1997); Figueroa(Arthroscopy 23(3):312-5, 2007;); Hjelle(Arthroscopy 18: 730-4, 2002). Examples of current attempts at cartilage restoration include marrow stimulating techniques, ostochondral autografts, osteochondral allografts, and autologous chondrocyte transplantation. Current research in marrow stimulating techniques has been focused on enhancing and guiding the biology of microfracture and other traditional techniques. Modern advances in stem cell biology and biotechnology have provided many avenues for exploration. The purpose of this work is to review current techniques in marrow stimulating techniques as it relates to chondral damage of the knee.
authors.affiliation: Penn State Hershey Bone and Joint Institute, 30 Hope Drive, Building B, Suite 2400, Hershey, PA, 17033-0850, USA. mmirza@hmc.psu.edu.
authors.forename: M Zain
authors.initials: MZ
authors.lastname: Mirza
authors.affiliation: Penn State Hershey Bone and Joint Institute, 30 Hope Drive, Building B, Suite 2400, Hershey, PA, 17033-0850, USA. rswenson@hmc.psu.edu.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Swenson
authors.affiliation: Penn State Hershey Bone and Joint Institute, 30 Hope Drive, Building B, Suite 2400, Hershey, PA, 17033-0850, USA. slynch@hmc.psu.edu.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Lynch
keywords: Bone marrow stimulation; Marrow stimulating techniques; Microfracture; Osteochondral lesion; Platelet-rich plasma; Scaffolding