title: CF3-Substituted semisquarate: a pluripotent building block for the divergent synthesis of trifluoromethylated functional molecules.
abstract: The first synthesis of a CF3-substituted semisquarate was accomplished via nucleophilic trifluoromethylation using CF3SiMe3 and subsequent rhenium-catalyzed allylic alcohol rearrangement. The short-step skeletal-divergent synthesis of trifluoromethylated functional molecules was successfully achieved using the CF3-substituted semisquarate as the platform.
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. yamamoto-yoshi@ps.nagoya-u.ac.jp.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. yamamoto-yoshi@ps.nagoya-u.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Kurohara
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. yamamoto-yoshi@ps.nagoya-u.ac.jp.
authors.forename: M
authors.initials: M
authors.lastname: Shibuya
mesh_terms: D060326:Chemistry Techniques, Synthetic; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000737:chemistry*; D005466:Fluorocarbons / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D011809:Quinones / Q000138:chemical synthesis*
chemical_list: D003503:Cyclobutanes; D005466:Fluorocarbons; D007202:Indicators and Reagents; D011809:Quinones