title: A systematic review of nonpharmacologic interventions for treatment-related symptoms in women with ovarian cancer.
abstract: BACKGROUND
  Women with ovarian cancer have a continued high symptom burden in comparison to other cancer survivors secondary to ongoing chemotherapy treatment. Prolonged or ineffective management of treatment-related symptoms can contribute to treatment noncompliance, worsening of symptoms, and reduced health-related quality of life.
  
  
  OBJECTIVE
  This review of the literature was conducted to describe experimental and quasi-experimental research addressing nonpharmacologic interventions for the treatment-related symptoms of sleep disturbance, pain, anxiety, depression, and low energy or fatigue in women with ovarian cancer and to critique the quality of interventions.
  
  
  METHODS
  A systematic search of the literature was conducted in PubMed and yielded 136 articles. Eight articles met the inclusion criteria and were evaluated.
  
  
  RESULTS
  Nonpharmacologic interventions for treatment-related symptoms were complex, with an average of 4.4 components. Intervention delivery, setting, and exposure varied widely across studies. Only three studies contained details sufficient to replicate the intervention. Lack of clarity in intervention reporting may explain perceptions of clinically inefficacious symptom management in this context. Greater attention to reporting would facilitate better translation of interventions into practice and when addressing complex cancer symptom clusters.
authors.affiliation: Indiana University in Indianapolis.
authors.forename: Lorie L
authors.initials: LL
authors.lastname: Davis
authors.affiliation: Indiana University in Indianapolis.
authors.forename: Janet S
authors.initials: JS
authors.lastname: Carpenter
mesh_terms: D001007:Anxiety / Q000628:therapy; D000072716:Cancer Pain / Q000628:therapy; D003863:Depression / Q000628:therapy; D005221:Fatigue / Q000628:therapy; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D012893:Sleep Wake Disorders / Q000628:therapy
keywords: chemotherapy; nonpharmacologic interventions; ovarian cancer; survivorship; symptom clusters; symptom management