title: [Role of Pediatric Critical Illness Score in evaluating severity and prognosis of severe hand-foot-mouth disease].
abstract: OBJECTIVE
  To investigate the role of Pediatric Critical Illness Score (PCIS) in evaluating the prognosis and severity of severe hand-foot-mouth disease (HFMD).
  
  
  METHODS
  This study included 424 children with severe HFMD, consisting of 390 survivors and 34 deceased patients. Related physiological parameters and clinical data were collected for calculating PCIS scores. The area under receiver operating characteristic curve (AUC) was employed to assess the performance of PCIS in evaluating the complications and outcomes.
  
  
  RESULTS
  The median of PCIS scores for survivors was higher than that for deceased patients (P<0.01). Of the 424 children with severe HFMD, only 26 (6.1%) had critical illness according to the severity assessment using PCIS. The AUC (95%CI) of PCIS was 0.74 (0.66, 0.82) in predicting pulmonary edema, 0.82 (0.74, 0.90) in predicting pulmonary hemorrhage, and 0.83 (0.75, 0.92) in predicting death.
  
  
  CONCLUSIONS
  PCIS can predict the complications and prognosis in children with severe HFMD. However, the existing scoring system of PCIS cannot fully assess the severity of HFMD.
authors.affiliation: School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. duyukai2000@163.com.
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Qiu
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Zhu
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Chao
authors.initials: C
authors.lastname: Zuo
authors.forename: Liang
authors.initials: L
authors.lastname: Tang
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Xiao
authors.forename: Yu-Kai
authors.initials: YK
authors.lastname: DU
mesh_terms: D002675:Child, Preschool; D016638:Critical Illness; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis