title: Boosting Classification Accuracy of Diffusion MRI Derived Brain Networks for the Subtypes of Mild Cognitive Impairment Using Higher Order Singular Value Decomposition.
abstract: Mild cognitive impairment (MCI) is an intermediate stage between normal aging and Alzheimer's disease (AD), and around 10-15% of people with MCI develop AD each year. More recently, MCI has been further subdivided into early and late stages, and there is interest in identifying sensitive brain imaging biomarkers that help to differentiate stages of MCI. Here, we focused on anatomical brain networks computed from diffusion MRI and proposed a new feature extraction and classification framework based on higher order singular value decomposition and sparse logistic regression. In tests on publicly available data from the Alzheimer's Disease Neuroimaging Initiative, our proposed framework showed promise in detecting brain network differences that help in classifying early versus late MCI.
authors.affiliation: Dept. of Neurology, University of California, Los Angeles, CA 90095, USA ; Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA.
authors.forename: L
authors.initials: L
authors.lastname: Zhan
authors.affiliation: Dept. of Computer Science and Engineering, Arizona State University, Tempe, AZ 85287, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Dept. of Computer Science and Engineering, Arizona State University, Tempe, AZ 85287, USA.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48105, USA ; Dept. of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48105, USA.
authors.forename: J
authors.initials: J
authors.lastname: Ye
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Thompson
keywords: Mild Cognitive Impairment; brain network; classification; diffusion MRI; high order SVD