title: Severe Neonatal Legionella Pneumonia: Full Recovery After Extracorporeal Life Support.
abstract: Legionella pneumophila is responsible for hospital or community-acquired pneumonia. Neonatal legionellosis is associated with rapidly severe clinical course and high mortality rates. We describe a case of hospital-acquired Legionella pneumonia in a newborn with undiagnosed tracheoesophageal fistula and acute respiratory failure requiring venovenous extracorporeal membrane oxygenation support before fistula repair. Standardized multiplex polymerase chain reaction assay allowed early diagnosis. Extracorporeal life support associated with appropriate antibiotic therapy, surfactant, and steroid therapy was effective in achieving complete recovery. This is the first report of successful neonatal extracorporeal life support for respiratory failure secondary to L pneumophila.
authors.affiliation: Neonatal and Pediatric ICU, Critical Care and Perinatal Medicine Department, and andreamoscatelli@me.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Moscatelli
authors.affiliation: Neonatal and Pediatric ICU, Critical Care and Perinatal Medicine Department, and.
authors.forename: Silvia
authors.initials: S
authors.lastname: Buratti
authors.affiliation: Infectious Diseases Unit, Istituto Giannina Gaslini, Genova, Italy; and.
authors.forename: Elio
authors.initials: E
authors.lastname: Castagnola
authors.affiliation: Infectious Diseases Unit, University of Genoa and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Aziendfa Ospedaliera Universitaria San Martino-IST (Istituto Nazionale per la Ricerca sul Cancro), Genova, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Mesini
authors.affiliation: Neonatal and Pediatric ICU, Critical Care and Perinatal Medicine Department, and.
authors.forename: Pietro
authors.initials: P
authors.lastname: Tuo
mesh_terms: D003428:Cross Infection / Q000175:diagnosis / Q000628:therapy*; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016952:Legionella pneumophila / Q000302:isolation & purification*; D007877:Legionnaires' Disease / Q000175:diagnosis / Q000628:therapy*; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000628:therapy*; D012720:Severity of Illness Index