title: Emerging circulating biomarkers in glioblastoma: promises and challenges.
abstract: Glioblastoma (GBM) is the most common and devastating primary malignant brain tumor in adults. The past few years have seen major progress in our understanding of the molecular basis of GBM. These advances, which have contributed to the development of novel targeted therapies, will change the paradigms in GBM therapy from disease-based to individually tailored molecular target-based treatment. No validated circulating biomarkers have yet been integrated into clinical practice for GBM. There is thus a critical need to implement minimally invasive clinical tests enabling molecular stratification and prognosis assessment, as well as the prediction and monitoring of treatment response. After examination of data from recent studies exploring several categories of tumor-associated biomarkers (circulating tumor cells, extracellular vesicles, nucleic acids and oncometabolites) identified in the blood, cerebrospinal fluid and urine, this article discusses the challenges and prospects for the development of circulating biomarkers in GBM.
authors.affiliation: a 1 Inserm U981, Université Paris Sud, Gustave Roussy, F-94805 Villejuif, France.|b 2 Département d'innovations thérapeutiques précoces, Gustave Roussy, F-94805 Villejuif, France.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Touat
authors.affiliation: c 3 AP-HP, Hôpital Universitaire la Pitié Salpêtrière, Service de Neurologie 2-Mazarin, F-75013, Paris, France.
authors.forename: Alberto
authors.initials: A
authors.lastname: Duran-Peña
authors.affiliation: c 3 AP-HP, Hôpital Universitaire la Pitié Salpêtrière, Service de Neurologie 2-Mazarin, F-75013, Paris, France.|d 4 Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France.
authors.forename: Agusti
authors.initials: A
authors.lastname: Alentorn
authors.affiliation: a 1 Inserm U981, Université Paris Sud, Gustave Roussy, F-94805 Villejuif, France.|e 5 Département de biologie médicale et de pathologie, Gustave Roussy, F-94805 Villejuif, France.|f 6 Laboratoire de recherche translationnelle et centre de ressources biologiques, Gustave Roussy, F-94805 Villejuif, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Lacroix
authors.affiliation: a 1 Inserm U981, Université Paris Sud, Gustave Roussy, F-94805 Villejuif, France.|b 2 Département d'innovations thérapeutiques précoces, Gustave Roussy, F-94805 Villejuif, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Massard
authors.affiliation: c 3 AP-HP, Hôpital Universitaire la Pitié Salpêtrière, Service de Neurologie 2-Mazarin, F-75013, Paris, France.|d 4 Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Idbaih
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001932:Brain Neoplasms / Q000097:blood*; D004273:DNA, Neoplasm / Q000097:blood; D000067128:Extracellular Vesicles / Q000378:metabolism; D005909:Glioblastoma / Q000097:blood* / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000097:blood; D009360:Neoplastic Cells, Circulating
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D035683:MicroRNAs
keywords: CTC; ctDNA; genomics; glioblastoma; liquid biopsies; microvesicles; non-invasive biomarkers; precision medicine