title: Associations between five-factor model of the Positive and Negative Syndrome Scale and plasma levels of monoamine metabolite in patients with schizophrenia.
abstract: The five-factor model of the Positive and Negative Syndrome Scale (PANSS) for schizophrenia symptoms is the most common multiple-factor model used in analyses; its use may improve evaluation of symptoms in schizophrenia patients. Plasma monoamine metabolite levels are possible indicators of clinical symptoms or response to antipsychotics in schizophrenia. We investigated the association between five-factor model components and plasma monoamine metabolites levels to explore the model's biological basis. Plasma levels of homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) were measured using high-performance liquid chromatography in 65 Japanese patients with schizophrenia. Significant negative correlation between plasma 5-HIAA levels and the depression/anxiety component was found. Furthermore, significant positive correlation was found between plasma MHPG levels and the excitement component. Plasma HVA levels were not correlated with any five-factor model component. These results suggest that the five-factor model of the PANSS may have a biological basis, and may be useful for elucidating the psychopathology of schizophrenia. Assessment using the five-factor model may enable understanding of monoaminergic dysfunction, possibly allowing more appropriate medication selection. Further studies of a larger number of first-episode schizophrenia patients are needed to confirm and extend these results.
authors.affiliation: Department of Pharmacy, Fukushima Medical University Hospital, Fukushima, Japan.
authors.forename: Kenya
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. Electronic address: itaru@fmu.ac.jp.
authors.forename: Itaru
authors.initials: I
authors.lastname: Miura
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kanno-Nozaki
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Horikoshi
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.
authors.forename: Hirobumi
authors.initials: H
authors.lastname: Mashiko
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan; Department of Neuropsychiatry, Fukushima Medical University Aizu Medical Center, Aizuwakamatsu, Fukushima, Japan.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Niwa
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.
authors.forename: Hirooki
authors.initials: H
authors.lastname: Yabe
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D007564:Japan; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood*; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D063189:Symptom Assessment / Q000379:methods*
chemical_list: D014150:Antipsychotic Agents; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid
keywords: 3-Methoxy-4-hydroxyphenylglycol sulfate; 5-Hydroxyindoleacetic acid; Five-factor model; Homovanillic acid; Positive and Negative Syndrome Scale