title: Palladium-Catalyzed Amination of N-Free 2-Chloro-7-azaindole.
abstract: A simple and efficient procedure for the Pd-catalyzed amination of N-free 2-chloro-7-azaindole is described, using either primary or secondary amines. An optimized combination of Brettphos, a Brettphos precatalyst, and LiHMDS in THF led us to a novel methodology, applied to various functionalized amines to study the scope of the reaction. This is the first report of cross-coupling amination on N-free 2-chloro-7-azaindole.
authors.affiliation: GICC UMR 7292 CNRS-Université de Tours, Equipe 4 Innovation Moléculaire et Thérapeutique, UFR Sciences Pharmaceutiques, 31 avenue Monge, 37200 Tours, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Plas
authors.affiliation: GICC UMR 7292 CNRS-Université de Tours, Equipe 4 Innovation Moléculaire et Thérapeutique, UFR Sciences Pharmaceutiques, 31 avenue Monge, 37200 Tours, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Martin
authors.affiliation: GICC UMR 7292 CNRS-Université de Tours, Equipe 4 Innovation Moléculaire et Thérapeutique, UFR Sciences Pharmaceutiques, 31 avenue Monge, 37200 Tours, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Joubert
authors.affiliation: GICC UMR 7292 CNRS-Université de Tours, Equipe 4 Innovation Moléculaire et Thérapeutique, UFR Sciences Pharmaceutiques, 31 avenue Monge, 37200 Tours, France.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Viaud-Massuard