title: Naphthylisoquinoline alkaloids potential drug leads.
abstract: Naphthylisoquinolines are a group of structurally diverse secondary metabolites, consisting of naphthalene and isoquinoline moieties. Naturally occurring naphthylisoquinolines have so far been found only in the small palaeotropic families Dioncophyllaceae and Ancistrocladaceae. They have been shown to exhibit a diverse array of biological activities. Herein, we review the research on the occurrence, isolation, identification, biological activities, and biosynthesis of this class of compounds published from 1995 till now. Moreover, their chemotaxonomic relevance and molecular targets of action have been discussed. More than 125 metabolites are described and 99 references are cited.
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: sabrinshaur@gmail.com.
authors.forename: Sabrin R M
authors.initials: SR
authors.lastname: Ibrahim
authors.affiliation: Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology; D045603:Dioncophyllaceae / Q000737:chemistry; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D019684:Magnoliopsida / Q000737:chemistry; D015394:Molecular Structure; D064209:Phytochemicals / Q000302:isolation & purification / Q000494:pharmacology*; D064210:Secondary Metabolism
chemical_list: D000470:Alkaloids; D000981:Antiprotozoal Agents; D007546:Isoquinolines; D064209:Phytochemicals; C039109:isoquinoline
keywords: Ancistrocladaceae; Biological activities; Biosynthesis; Chemotaxonomic relevance; Dioncophyllaceae; Naphthylisoquinolines