title: Spray versus intralesional cryotherapy for keloids.
abstract: BACKGROUND
  Keloids may follow local skin trauma or inflammation leading to pruritus, pain, restriction of movement or cosmetic disfigurement.
  
  
  OBJECTIVE
  To compare between the efficacy and tolerability of spray versus intralesional cryotherapy for keloids.
  
  
  METHODS
  Fifty patients with keloids were randomized to treatment with spray cryotherapy (group I) or intralesional cryotherapy (group II). Swada and Sone scoring of scars was performed at treatment and follow-up (6 months). Histopathological examination was done before and after end of treatment sessions.
  
  
  RESULTS
  Intralesional cryotherapy showed greater efficacy than spray cryotherapy. Fewer treatments were required with intralesional cryotherapy than with spray cryotherapy.
  
  
  CONCLUSIONS
  Intralesional cryotherapy was more effective and tolerable modality for treatment of keloids than spray technique with greater internal freezing area.
authors.affiliation: a Dermatology & Venereology Department, Faculty of Medicine , Tanta University , Tanta , Egypt.
authors.forename: Basma
authors.initials: B
authors.lastname: Mourad
authors.affiliation: a Dermatology & Venereology Department, Faculty of Medicine , Tanta University , Tanta , Egypt.
authors.forename: Nashwa
authors.initials: N
authors.lastname: Elfar
authors.affiliation: a Dermatology & Venereology Department, Faculty of Medicine , Tanta University , Tanta , Egypt.
authors.forename: Shimaa
authors.initials: S
authors.lastname: Elsheikh
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000336:Aerosols; D011241:Prednisone
keywords: Cryotherapy; intralesional; keloids; spray