title: Objectively Measured Sedentary Time and Cardiometabolic Biomarkers in US Hispanic/Latino Adults: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
abstract: BACKGROUND
  Sedentary behavior is recognized as a distinct construct from lack of moderate-vigorous physical activity and is associated with deleterious health outcomes. Previous studies have primarily relied on self-reported data, whereas data on the relationship between objectively measured sedentary time and cardiometabolic biomarkers are sparse, especially among US Hispanics/Latinos.
  
  
  RESULTS
  We examined associations of objectively measured sedentary time (via Actical accelerometers for 7 days) and multiple cardiometabolic biomarkers among 12 083 participants, aged 18 to 74 years, from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos of diverse backgrounds (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) were recruited from 4 US cities between 2008 and 2011. Sedentary time (<100 counts/min) was standardized to 16 hours/d of wear time. The mean sedentary time was 11.9 hours/d (74% of accelerometer wear time). After adjustment for moderate-vigorous physical activity and confounding variables, prolonged sedentary time was associated with decreased high-density lipoprotein cholesterol (P=0.04), and increased triglycerides, 2-hour glucose, fasting insulin, and homeostatic model assessment of insulin resistance (all P<0.0001). These associations were generally consistent across age, sex, Hispanic/Latino backgrounds, and physical activity levels. Even among individuals meeting physical activity guidelines, sedentary time was detrimentally associated with several cardiometabolic biomarkers (diastolic blood pressure, high-density lipoprotein cholesterol, fasting and 2-hour glucose, fasting insulin and homeostatic model assessment of insulin resistance; all P<0.05).
  
  
  CONCLUSIONS
  Our large population-based, objectively derived data showed deleterious associations between sedentary time and cardiometabolic biomarkers, independent of physical activity, in US Hispanics/Latinos. Our findings emphasize the importance of reducing sedentary behavior for the prevention of cardiometabolic diseases, even in those who meet physical activity recommendations.
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.). qibin.qi@einstein.yu.edu.
authors.forename: Qibin
authors.initials: Q
authors.lastname: Qi
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Garrett
authors.initials: G
authors.lastname: Strizich
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Gina
authors.initials: G
authors.lastname: Merchant
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Daniela
authors.initials: D
authors.lastname: Sotres-Alvarez
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Christina
authors.initials: C
authors.lastname: Buelna
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Sheila F
authors.initials: SF
authors.lastname: Castañeda
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Linda C
authors.initials: LC
authors.lastname: Gallo
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Jianwen
authors.initials: J
authors.lastname: Cai
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Marc D
authors.initials: MD
authors.lastname: Gellman
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Carmen R
authors.initials: CR
authors.lastname: Isasi
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Moncrieft
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Lisa
authors.initials: L
authors.lastname: Sanchez-Johnsen
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Neil
authors.initials: N
authors.lastname: Schneiderman
authors.affiliation: From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
authors.forename: Robert C
authors.initials: RC
authors.lastname: Kaplan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D008076:Cholesterol, HDL / Q000097:blood*; D006630:Hispanic or Latino; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D057185:Sedentary Behavior; D013997:Time Factors
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D007328:Insulin
keywords: Hispanic Americans; cardiovascular diseases; epidemiology; risk factors; sedentary lifestyle