title: Functionalization of electrospun poly(caprolactone) fibers for pH-controlled delivery of doxorubicin hydrochloride.
abstract: Functionalized electrospun polymer fibers are a promising candidate for controlled delivery of chemotherapeutic drugs to improve the therapeutic efficacy and to reduce the potential toxic effects by delivering the drug at a rate governed by the physiological need of the site of action. In this study, poly(caprolactone) (PCL) fibers were fabricated by electrospinning, followed by hydrolyzation to introduce functional groups on the fiber surface. Characterization studies were performed on these functionalized fibers using X-ray photoelectron spectroscopy, scanning electron microscopy, and Toluidine Blue O dye assay. The pH-sensitivity of the functional groups on the fiber surface and doxorubicin hydrochloride was utilized to bind the drug electrostatically to these functionalized PCL fibers. The effect of pH on drug loading and release kinetics was investigated. Results indicate successful electrostatic binding of the drug to functionalized electrospun fibers and a high drug payload. The drug delivery response can be modulated by introduction of suitable stimuli (pH).
authors.affiliation: a Biomedical Engineering and Biotechnology Program , University of Massachusetts Dartmouth , 285 Old Westport Road, Dartmouth , MA 02747 , USA.
authors.forename: Manisha
authors.initials: M
authors.lastname: Jassal
authors.affiliation: b Department of Civil and Environmental Engineering , University of Massachusetts Dartmouth , 285 Old Westport Road, Dartmouth , MA 02747 , USA.
authors.forename: Sukalyan
authors.initials: S
authors.lastname: Sengupta
authors.affiliation: c Department of Mechanical Engineering , University of Massachusetts Dartmouth , 285 Old Westport Road, Dartmouth , MA 02747 , USA.
authors.forename: Sankha
authors.initials: S
authors.lastname: Bhowmick
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D056951:Photoelectron Spectroscopy; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D055672:Static Electricity; D014048:Tolonium Chloride
chemical_list: D000903:Antibiotics, Antineoplastic; D011091:Polyesters; D014048:Tolonium Chloride; C016240:polycaprolactone; D004317:Doxorubicin
keywords: characterization; doxorubicin hydrochloride; electrospinning; functionalization; pH-controlled delivery; poly(caprolactone)