title: Effects of waterborne fluoxetine on stress response and osmoregulation in zebrafish.
abstract: The presence of fluoxetine in aquatic environments has been reported for decades. Here, we investigate the effects of exposure to fluoxetine on the stress response and osmoregulation in zebrafish. We show that stress response alters osmoregulation and that fluoxetine inhibits these stress-related changes in osmoregulation. The results suggest that the presence of fluoxetine in aquatic ecosystems can cause changes in response to stress and osmoregulation in fish.
authors.affiliation: Universidade Federal de Santa Maria (UFSM), Programa de Pós-Graduação em Farmacologia, Campus Universitário, Camobi, Santa Maria, RS, Brazil. Electronic address: abreu_murilo@hotmail.com.
authors.forename: Murilo S
authors.initials: MS
authors.lastname: Abreu
authors.affiliation: Universidade Federal de Santa Maria (UFSM), Programa de Pós-Graduação em Farmacologia, Campus Universitário, Camobi, Santa Maria, RS, Brazil; Universidade de Passo Fundo (UPF), Programa de Pós-Graduação em Bioexperimentação, Campus I, Bairro São José, Caixa Postal 611, Passo Fundo, RS, Brazil. Electronic address: anacvg@upf.br.
authors.forename: Ana Cristina V
authors.initials: AC
authors.lastname: Giacomini
authors.affiliation: Universidade Federal de Santa Maria (UFSM), Programa de Pós-Graduação em Farmacologia, Campus Universitário, Camobi, Santa Maria, RS, Brazil. Electronic address: gessikoakoski@yahoo.com.br.
authors.forename: Gessi
authors.initials: G
authors.lastname: Koakoski
authors.affiliation: Universidade Federal de Santa Maria (UFSM), Programa de Pós-Graduação em Farmacologia, Campus Universitário, Camobi, Santa Maria, RS, Brazil. Electronic address: thiago_a.oliveira@hotmail.com.
authors.forename: Thiago A
authors.initials: TA
authors.lastname: Oliveira
authors.affiliation: Universidade de Passo Fundo (UPF), Programa de Pós-Graduação em Bioexperimentação, Campus I, Bairro São José, Caixa Postal 611, Passo Fundo, RS, Brazil. Electronic address: gusso.d@hotmail.com.
authors.forename: Darlan
authors.initials: D
authors.lastname: Gusso
authors.affiliation: Universidade Federal de Santa Maria (UFSM), Programa de Pós-Graduação em Farmacologia, Campus Universitário, Camobi, Santa Maria, RS, Brazil. Electronic address: bbaldisserotto@hotmail.com.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Baldisserotto
authors.affiliation: Universidade Federal de Santa Maria (UFSM), Programa de Pós-Graduação em Farmacologia, Campus Universitário, Camobi, Santa Maria, RS, Brazil; Universidade de Passo Fundo (UPF), Programa de Pós-Graduação em Bioexperimentação, Campus I, Bairro São José, Caixa Postal 611, Passo Fundo, RS, Brazil. Electronic address: lbarcellos@upf.br.
authors.forename: Leonardo J G
authors.initials: LJ
authors.lastname: Barcellos
mesh_terms: D000818:Animals; D005260:Female; D005473:Fluoxetine / Q000633:toxicity*; D008297:Male; D064587:Osmoregulation / Q000187:drug effects*; D013312:Stress, Physiological / Q000187:drug effects*; D014874:Water Pollutants, Chemical / Q000633:toxicity; D015027:Zebrafish
chemical_list: D014874:Water Pollutants, Chemical; D005473:Fluoxetine
keywords: Cortisol; Danio rerio; Homeostasis; Osmoregulation; Psychotropic drug; SSRI