title: Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement.
abstract: Particle and domain sizes strongly influence the properties of materials. Here we present an NMR approach based on paramagnetic relaxation enhancement (PRE) relayed by spin diffusion (SD), which allows us to determine lengths in the nm-μm range. We demonstrate the method on multicomponent organic polymer mixtures by selectively doping one component with a paramagnetic center in order to measure the domain size in a second component. Using this approach we determine domain sizes in ethyl cellulose/hydroxypropyl cellulose film coatings in pharmaceutical controlled release formulations. Here we measure particle sizes ranging from around 50 to 200 nm.
authors.affiliation: Institut de Science Analytiques, Centre de RMN à très hauts champs, Université de Lyon , CNRS/ENS de Lyon/UCB Lyon1, 69100 Villeurbanne, France.
authors.forename: Judith
authors.initials: J
authors.lastname: Schlagnitweit
authors.affiliation: Institut de Science Analytiques, Centre de RMN à très hauts champs, Université de Lyon , CNRS/ENS de Lyon/UCB Lyon1, 69100 Villeurbanne, France.
authors.forename: Mingxue
authors.initials: M
authors.lastname: Tang
authors.affiliation: Institut de Science Analytiques, Centre de RMN à très hauts champs, Université de Lyon , CNRS/ENS de Lyon/UCB Lyon1, 69100 Villeurbanne, France.
authors.forename: Maria
authors.initials: M
authors.lastname: Baias
authors.affiliation: R&D Pharmaceutical Development, AstraZeneca , 431 50 Mölndal, Sweden.
authors.forename: Sara
authors.initials: S
authors.lastname: Richardson
authors.affiliation: R&D Pharmaceutical Development, AstraZeneca , 431 50 Mölndal, Sweden.
authors.forename: Staffan
authors.initials: S
authors.lastname: Schantz
authors.affiliation: Institut de Science Analytiques, Centre de RMN à très hauts champs, Université de Lyon , CNRS/ENS de Lyon/UCB Lyon1, 69100 Villeurbanne, France.|Institut des Sciences et Ingénierie Chimiques , Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
authors.forename: Lyndon
authors.initials: L
authors.lastname: Emsley
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D049329:Nanostructures / Q000737:chemistry*
chemical_list: C013517:ethyl cellulose; D002482:Cellulose; C008079:hydroxypropylcellulose