title: In Vitro Modeling of Brain Progenitor Cell Development under the Effect of Environmental Factors.
abstract: We studied in vitro development of brain progenitor cells isolated from healthy 7-9-month-old Wistar rats and rats with experimental Alzheimer's disease kept under standard conditions and in enriched (multistimulus) environment in vivo. Progenitor cells from healthy animals more rapidly formed neurospheres. Considerable changes at the early stages of in vitro development of brain progenitor cells were observed in both groups kept in enriched environment.
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia. natalya.kuvacheva@gmail.com.
authors.forename: N V
authors.initials: NV
authors.lastname: Kuvacheva
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Morgun
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: Yu K
authors.initials: YK
authors.lastname: Komleva
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: E D
authors.initials: ED
authors.lastname: Khilazheva
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: Ya V
authors.initials: YV
authors.lastname: Gorina
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: O L
authors.initials: OL
authors.lastname: Lopatina
authors.affiliation: Siberian State Technological University, Krasnoyarsk, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Arutyunyan
authors.affiliation: V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D001921:Brain / Q000473:pathology; D049109:Cell Proliferation; D002478:Cells, Cultured; D004777:Environment; D004779:Environment Design; D006799:Housing, Animal; D058953:Neural Stem Cells / Q000502:physiology*; D017208:Rats, Wistar
keywords: enriched environment; neurogenesis; progenitor cells