title: Pharmacokinetics and bioavailability of flumequine in blunt snout bream (Megalobrama amblycephala) after intravascular and oral administrations.
abstract: In this study, the pharmacokinetic profile of flumequine (FMQ) was investigated in blunt snout bream (Megalobrama amblycephala) after intravascular (3 mg/kg body weight (b.w.)) and oral (50 mg/kg b.w.) administrations. The plasma samples were determinedby ultra-performance liquid chromatography (UPLC) with fluorescence detection. After intravascular administration, plasma concentration-time curves were best described by a two-compartment open model. The distribution half-life (t1/2α ), elimination half-life (t1/2β ), and area under the concentration-time curve (AUC) of blunt snout bream were 0.6 h, 25.0 h, and 10612.7 h·μg/L, respectively. After oral administration, a two-compartment open model with first-order absorption was also best fit the data of plasma. The t1/2α , t1/2β , peak concentration (Cmax ), time-to-peak concentration (Tmax ), and AUC of blunt snout bream were estimated to be 2.5 h, 19.7 h, 3946.5 μg/L, 1.4 h, and 56618.1 h. μg/L, respectively. The oral bioavailability (F) was 32.0%. The pharmacokinetics of FMQ in blunt snout bream displayed low bioavailability, rapid absorption, and rapid elimination.
authors.affiliation: Freshwater Fish Germplasm Quality Supervision and Testing Center, Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.|Hu Bei Freshwater Aquaculture Collaborative Innovation Center, Wuhan, China.
authors.forename: N
authors.initials: N
authors.lastname: Xu
authors.affiliation: Freshwater Fish Germplasm Quality Supervision and Testing Center, Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.
authors.forename: J
authors.initials: J
authors.lastname: Dong
authors.affiliation: Freshwater Fish Germplasm Quality Supervision and Testing Center, Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Freshwater Fish Germplasm Quality Supervision and Testing Center, Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Freshwater Fish Germplasm Quality Supervision and Testing Center, Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.|Hu Bei Freshwater Aquaculture Collaborative Innovation Center, Wuhan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Freshwater Fish Germplasm Quality Supervision and Testing Center, Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.|Hu Bei Freshwater Aquaculture Collaborative Innovation Center, Wuhan, China.
authors.forename: X
authors.initials: X
authors.lastname: Ai
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D003530:Cyprinidae / Q000097:blood / Q000378:metabolism*; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000892:Anti-Infective Agents, Urinary; D024841:Fluoroquinolones; C012976:flumequine