title: Alzheimer Disease Cerebrospinal Fluid Biomarkers Moderate Baseline Differences and Predict Longitudinal Change in Attentional Control and Episodic Memory Composites in the Adult Children Study.
abstract: Cognitive measures that are sensitive to biological markers of Alzheimer disease (AD) pathology are needed to (a) facilitate preclinical staging, (b) identify individuals who are at the highest risk for developing clinical symptoms, and (c) serve as endpoints for evaluating the efficacy of interventions. The present study assesses the utility of two cognitive composite scores of attentional control and episodic memory as markers for preclinical AD pathology in a group of cognitively normal older adults (N = 238), as part of the Adult Children Study. All participants were given a baseline cognitive assessment and follow-up assessments every 3 years over an 8-year period, as well as a lumbar puncture within 2 years of the initial assessment to collect cerebrospinal fluid (CSF) and amyloid tracer Pittsburgh compound-B scan for amyloid imaging. Results indicated that attentional control was correlated with levels of Aβ42 at the initial assessment whereas episodic memory was not. Longitudinally, individuals with high CSF tau exhibited a decline in both attention and episodic memory over the course of the study. These results indicate that measures of attentional control and episodic memory can be used to evaluate cognitive decline in preclinical AD and provide support that CSF tau may be a key mechanism driving longitudinal cognitive change.
authors.affiliation: 1Department of Psychology,Washington University in St. Louis,St. Louis,Missouri.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Aschenbrenner
authors.affiliation: 1Department of Psychology,Washington University in St. Louis,St. Louis,Missouri.
authors.forename: David A
authors.initials: DA
authors.lastname: Balota
authors.affiliation: 2Department of Neurology,Washington University in St. Louis,St. Louis,Missouri.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Fagan
authors.affiliation: 1Department of Psychology,Washington University in St. Louis,St. Louis,Missouri.
authors.forename: Janet M
authors.initials: JM
authors.lastname: Duchek
authors.affiliation: 3The Knight Alzheimer Disease Research Center,Washington University in St. Louis,St. Louis,Missouri.
authors.forename: Tammie L S
authors.initials: TL
authors.lastname: Benzinger
authors.affiliation: 2Department of Neurology,Washington University in St. Louis,St. Louis,Missouri.
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000150:complications* / Q000000981:diagnostic imaging; D000814:Aniline Compounds / Q000493:pharmacokinetics; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology*; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D013844:Thiazoles / Q000493:pharmacokinetics
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D015415:Biomarkers; D013844:Thiazoles
keywords: Alzheimer disease; Amyloid; Attention; Biological markers; Episodic memory; Longitudinal study