title: [Bone Cell Biology Assessed by Microscopic Approach. A mathematical approach to understand bone remodeling].
abstract: It is well known that bone tissue can change its outer shape and internal structure by remodeling according to a changing mechanical environment. However, the mechanism of bone functional adaptation induced by the collaborative metabolic activities of bone cells in response to mechanical stimuli remains elusive. In this article, we focus on the hierarchy of bone structure and function from the microscopic cellular level to the macroscopic tissue level. We provide an overview of a mathematical approach to understand the adaptive changes in trabecular morphology under the application of mechanical stress.
authors.affiliation: Department of Biomechanics, Institute for Frontier Medical Sciences, Kyoto University, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kameo
authors.forename: Taiji
authors.initials: T
authors.lastname: Adachi
mesh_terms: D000222:Adaptation, Physiological; D016723:Bone Remodeling; D001842:Bone and Bones / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D013314:Stress, Mechanical