title: Prognostic importance of pentraxin 3 levels in acute cholesistitis.
abstract: BACKGROUND
  Cholelithiasis is a frequently encountered problem in developed countries. Gallstone is present in at least 10% of the adults. While 40-60% of people with gallstones manifest an asymptomatic clinical course, in most of the cases with symptomatic cholelithiasis, there is also an asymptomatic period. 20% of the patients with symptomatic gallstones are admitted to emergency services with clinical features of acute cholecystitis. In this study, our aim was to evaluate the diagnostic value of pentraxin 3 on complications and prognosis and also to reduce the morbidity and mortality rates in cases with acute cholecystitis.
  
  
  METHODS
  This study was conducted on patients diagnosed with acute calculous cholecystitis and operated on between September 2012 and January 2014, in the Department of General Surgery of Atatürk University Medical Faculty. Forty-five patients with ages above 18, who were clinically and radiologically diagnosed with acute calculous cholecystitis (Group I) and 45 healthy people, older than 18 (Group II) were included into the study. Patients were randomly selected.
  
  
  RESULTS
  In our study, although the plasma pentraxin 3 (PTX3) levels were increased in the patient group and also in patients who developed morbidity, this was not statistically significant. PTX3 values were determined to be significantly increased in older patients (p<0.05). Moreover, when the duration of hospital stays were compared, PTX3 was found to be significantly higher in patients hospitalized for longer periods (p<0.05).
  
  
  CONCLUSIONS
  PTX3 levels were found to be elevated in all evaluated parameters in patients with acute cholecystitis. Therefore, PTX3 level may be a valuable indicator in diagnosis and also in predicting prognosis.
authors.affiliation: Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Nurhak
authors.initials: N
authors.lastname: Aksungur
authors.affiliation: Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Bünyami
authors.initials: B
authors.lastname: Özoğul
authors.affiliation: Department of Biochemistry, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Nurunnisa
authors.initials: N
authors.lastname: Öztürk
authors.affiliation: Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Arslan
authors.affiliation: Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Karadeniz
authors.affiliation: Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Korkut
authors.affiliation: Department of Biochemistry, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Gül
authors.affiliation: Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Kısaoğlu
authors.affiliation: Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Sabri Selçuk
authors.initials: SS
authors.lastname: Atamanalp
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D002764:Cholecystitis / Q000097:blood*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D014421:Turkey; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins