title: Clinical and Microbiological Characteristics of Invasive Group A Streptococcal Infections Before and After Implementation of a Universal Varicella Vaccine Program.
abstract: Since the introduction of the varicella vaccine to the routine immunization schedule, we have observed a 70% reduction in the rate of varicella-associated invasive group A streptococcal infections (IGASI). In the mean time, the clinical presentation of IGASI and microbiological characteristics of GAS strains have changed significantly.
authors.affiliation: Infectious Diseases Division, Department of Pediatrics, Centre Hospitalo-Universitaire Sainte Justine, Université de Montréal, Québec, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Frère
authors.affiliation: Microbiology Department, Hôpital Robert Debré, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bidet
authors.affiliation: Infectious Diseases Division, Department of Pediatrics, Centre Hospitalo-Universitaire Sainte Justine, Université de Montréal, Québec, Canada.
authors.forename: Bruce
authors.initials: B
authors.lastname: Tapiéro
authors.affiliation: Microbiology and Immunology Department, Centre Hospitalo-Universitaire Sainte Justine, Université de Montréal, Québec, Canada.
authors.forename: Fabien
authors.initials: F
authors.lastname: Rallu
authors.affiliation: Pediatric Emergency, Centre Hospitalo-Universitaire Nord, Marseille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Minodier
authors.affiliation: Microbiology Department, Hôpital Robert Debré, Paris, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Bonacorsi
authors.affiliation: Microbiology Department, Hôpital Robert Debré, Paris, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
authors.affiliation: Infectious Diseases Division, Department of Pediatrics, Centre Hospitalo-Universitaire Sainte Justine, Université de Montréal, Québec, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Ovetchkine
mesh_terms: D019433:Chickenpox Vaccine; D002648:Child; D002675:Child, Preschool; D019115:Fasciitis, Necrotizing; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D013297:Streptococcus pyogenes
chemical_list: D019433:Chickenpox Vaccine
keywords: invasive streptococcal infection; necrotizing fasciitis; pediatrics; varicella vaccine