title: Brimonidine Induced Anterior Uveitis.
abstract: OBJECTIVE
  To present the largest series reported so far of brimonidine induced granulomatous anterior uveitis.
  
  
  METHODS
  Retrospective chart review of patients with chronic glaucoma on treatment with brimonidine presenting with anterior uveitis.
  
  
  RESULTS
  19 eyes of 12 patients with chronic glaucoma developed anterior uveitis with granulomatous keratic precipitates after being treated with brimonidine for periods of 7 days to 5 years (mean 19.7 months, +18.6 months). One patient had a gap of 1 year between onset in one eye and onset in the other. Ten eyes (52.6%) had concurrent granulomatous conjunctivitis; 16 eyes were pseudophakic. Stopping brimonidine led to complete, rapid resolution of uveitis in all patients, in most cases (11 eyes, 58%) without topical corticosteroids. No recurrences have occurred after withdrawal of brimonidine, over a follow-up period of 12-52 months (mean 27.9 months, +13.8 months).
  
  
  CONCLUSIONS
  Ophthalmologists should be aware of this easily reversible uveitis syndrome that is induced by a common glaucoma medication. Familiarity with this entity is essential in making the correct diagnosis and avoiding unnecessary investigations and interventions.
authors.affiliation: a Centre For Eye Research Australia, The Royal Victorian Eye and Ear Hospital , Melbourne , Australia and.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Beltz
authors.affiliation: a Centre For Eye Research Australia, The Royal Victorian Eye and Ear Hospital , Melbourne , Australia and.|b Melbourne Eye Specialists , Fitzroy , Victoria , Australia.
authors.forename: Ehud
authors.initials: E
authors.lastname: Zamir
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000009:adverse effects*; D000368:Aged; D000369:Aged, 80 and over; D000068438:Brimonidine Tartrate / Q000009:adverse effects*; D003231:Conjunctivitis / Q000139:chemically induced / Q000175:diagnosis; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000175:diagnosis; D028761:Withholding Treatment
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D000068438:Brimonidine Tartrate
keywords: Brimonidine uveitis; drug induced uveitis