title: Successful Treatment of a Child With Extensively Drug-Resistant Tuberculous Meningitis.
abstract: Unlike in pulmonary multidrug-resistant (MDR) tuberculosis, the clinical outcome of MDR tuberculous meningitis (TBM) in children, including extensively drug-resistant tuberculosis, is poor and management is challenging. We report the successful treatment of a case of extensively drug-resistant TBM in a 4-year-old girl, and we discuss implications for tuberculosis diagnosis and chemotherapy.
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
authors.forename: Neele
authors.initials: N
authors.lastname: Alsleben
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Garcia-Prats
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
authors.forename: Anneke C
authors.initials: AC
authors.lastname: Hesseling
authors.affiliation: Brooklyn Hospital for Chest Diseases, Cape Town, South Africa.
authors.forename: Marianne
authors.initials: M
authors.lastname: Willemse
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Donald
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Brooklyn Hospital for Chest Diseases, Cape Town, South Africa Tygerberg Children's Hospital, Cape Town, South Africa.
authors.forename: H Simon
authors.initials: HS
authors.lastname: Schaaf
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000009:adverse effects; D054908:Extensively Drug-Resistant Tuberculosis / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced / Q000188:drug therapy; D007555:Isoxazoles / Q000008:administration & dosage / Q000009:adverse effects; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis; D023303:Oxazolidinones / Q000008:administration & dosage / Q000009:adverse effects; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome; D014390:Tuberculosis, Meningeal / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D000995:Antitubercular Agents; D007555:Isoxazoles; D023303:Oxazolidinones; C100142:terizidone; D011239:Prednisolone
keywords: Western Cape; extensively drug-resistant; linezolid; treatment; tuberculous meningitis