title: Preventing Onset of Anxiety Disorders in Offspring of Anxious Parents: A Randomized Controlled Trial of a Family-Based Intervention.
abstract: OBJECTIVE
  The authors examined the efficacy of a family-based intervention to prevent the onset of anxiety disorders in offspring of anxious parents.
  
  
  METHODS
  Participants were 136 families with a parent meeting DSM-IV criteria for an anxiety disorder and one child 6-13 years of age without an anxiety disorder. Families were randomly assigned to the family-based intervention (N=70) or to an information-monitoring control condition (N=66). All families were expected to complete assessments, administered by blind interviewers, at baseline, at the end of the intervention (or 8 weeks after randomization) and at 6- and 12-month follow-ups. Onset of any anxiety disorder and anxiety symptom severity (assessed using the Anxiety Disorders Interview Schedule for Children) at 12 months were the primary and secondary outcome measures, respectively.
  
  
  RESULTS
  The incidence of child anxiety disorders was 31% in the control group and 5% in the intervention group (odds ratio=8.54, 95% CI=2.27, 32.06). At the 1-year follow-up, youths in the control group also had higher anxiety symptoms ratings than those in the intervention group. Effect sizes were medium to large (0.81 at 6 months and 0.57 at 12 months for anxiety symptoms), and the number needed to treat was 3.9 at 12 months. Significant moderators included baseline levels of child anxiety; significant mediators were parental distress and modeling of anxiety. Child maladaptive cognitions and parental anxiety did not mediate outcomes.
  
  
  CONCLUSIONS
  A brief psychosocial prevention program holds promise for reducing the 1-year incidence of anxiety disorders among offspring of anxious parents.
authors.affiliation: From the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
authors.forename: Golda S
authors.initials: GS
authors.lastname: Ginsburg
authors.affiliation: From the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Drake
authors.affiliation: From the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
authors.forename: Jenn-Yun
authors.initials: JY
authors.lastname: Tein
authors.affiliation: From the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
authors.forename: Rebekah
authors.initials: R
authors.lastname: Teetsel
authors.affiliation: From the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Riddle
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000517:prevention & control* / Q000523:psychology; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology*; D005196:Family Therapy; D005260:Female; D006801:Humans; D008297:Male; D016896:Treatment Outcome