title: Paget Disease of Bone.
abstract: The current understanding of Paget disease of bone (PDB) has vastly changed since Paget described the first case in 1877. Medical management of this condition remains the mainstay of treatment. Surgical intervention is usually only used in fractures through pagetic bone, need for realignment to correct deformity in major long bones, prophylactic treatment of impending fractures, joint arthroplasty in severe arthritis, or spinal decompression in cases of bony compression of neural elements. Advances in surgical technique have allowed early return to function and mobilization. Despite medical and surgical intervention, a small subset of patients with PDB develops Paget sarcoma.
authors.affiliation: Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Mamun
authors.initials: M
authors.lastname: Al-Rashid
authors.affiliation: Department of Orthopaedic Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA.
authors.forename: Dipak B
authors.initials: DB
authors.lastname: Ramkumar
authors.affiliation: Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Raskin
authors.affiliation: Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Schwab
authors.affiliation: Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Hornicek
authors.affiliation: Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address: slozanocalderon@mgh.harvard.edu.
authors.forename: Santiago A
authors.initials: SA
authors.lastname: Lozano-Calderón
mesh_terms: D006801:Humans; D010001:Osteitis Deformans / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy
keywords: Arthroplasty in Paget disease; Bisphosphonates; Bone turnover; Fracture fixation of pagetic bone; Paget; Paget disease of bone; Paget sarcoma; SQSTM1