title: Microstructure-modified biodegradable magnesium alloy for promoting cytocompatibility and wound healing in vitro.
abstract: The microstructure of biomedical magnesium alloys has great influence on anti-corrosion performance and biocompatibility. In practical application and for the purpose of microstructure modification, heat treatments were chosen to provide widely varying microstructures. The aim of the present work was to investigate the influence of the microstructural parameters of an Al-free Mg-Zn-Zr alloy (ZK60), and the corresponding heat-treatment-modified microstructures on the resultant corrosion resistance and biological performance. Significant enhancement in corrosion resistance was obtained in Al-free Mg-Zn-Zr alloy (ZK60) through 400 °C solid-solution heat treatment. It was found that the optimal condition of solid-solution treatment homogenized the matrix and eliminated internal defects; after which, the problem of unfavorable corrosion behavior was improved. Further, it was also found that the Mg ion-release concentration from the modified ZK60 significantly induced the cellular activity of fibroblast cells, revealing in high viability value and migration ability. The experimental evidence suggests that this system can further accelerate wound healing. From the perspective of specific biomedical applications, this research result suggests that the heat treatment should be applied in order to improve the biological performance.
authors.affiliation: Department of Materials Science and Engineering, National Cheng Kung University, Tainan, 701, Taiwan.
authors.forename: Da-Jun
authors.initials: DJ
authors.lastname: Lin
authors.affiliation: Department of Materials Science and Engineering, National Cheng Kung University, Tainan, 701, Taiwan. fyhung@mail.ncku.edu.tw.
authors.forename: Fei-Yi
authors.initials: FY
authors.lastname: Hung
authors.affiliation: Department of Biomedical Engineering, National Cheng Kung University, Tainan, 701, Taiwan.
authors.forename: Ming-Long
authors.initials: ML
authors.lastname: Yeh
authors.affiliation: Department of Materials Science and Engineering, National Cheng Kung University, Tainan, 701, Taiwan.
authors.forename: Truan-Sheng
authors.initials: TS
authors.lastname: Lui
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival; D003343:Corrosion; D055664:Electrochemical Techniques; D006358:Hot Temperature; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D014945:Wound Healing
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; C586529:ZK60 magnesium alloy; D008274:Magnesium