title: Improvement of Cognitive and Psychomotor Performance in Patients with Mild to Moderate Obstructive Sleep Apnea Treated with Mandibular Advancement Device: A Prospective 1-Year Study.
abstract: OBJECTIVE
  This study aimed to provide the evidence on effect of mandibular advancement device (MAD) therapy on long-term cognitive and psychomotor performance, excessive daytime sleepiness, and quality of life in patients with mild to moderate obstructive sleep apnea (OSA).
  
  
  METHODS
  A total of 15 patients with mild to moderate OSA were treated with MAD therapy and they were followed up after 3 mo and 1 y of therapy. The patients were tested on three different tests of cognitive and psychomotor performance using the computer-based system Complex Reactionmeter Drenovac (CRD-series) at baseline and at the time of follow-up, and the 36-Item Short Form Health Survey (SF-36) questionnaire and Epworth Sleepiness Scale were used to assess their quality of life and excessive daytime sleepiness, respectively.
  
  
  RESULTS
  The mean apnea-hypopnea index (AHI) decreased significantly from 22.9 ± 5.9 events/h at baseline, to 9.7 ± 4.5 events/h after 1 y of MAD therapy (p < 0.001). There was significant improvement on all three CRD-series tests used after 1 y of MAD therapy, considering total test solving time (TTST) and minimal single task solving time (MinT), whereas total number of errors committed during the tests (TE) remained unchanged. Self-reported measures, excessive daytime sleepiness, and three domains of quality of life, social functioning, general health perception, and health change following MAD therapy showed significant improvements after 1 y of MAD therapy.
  
  
  CONCLUSIONS
  This study demonstrates significant improvements in cognitive and psychomotor performance, particularly in the domain of perceptive abilities, convergent thinking (constructing and solving simple mathematical tasks) and psychomotor reaction times, excessive daytime sleepiness, and quality of life in patients with mild to moderate OSA following MAD therapy.
authors.affiliation: Study of Dental Medicine, University of Split School of Medicine, Split, Croatia.
authors.forename: Tea
authors.initials: T
authors.lastname: Galic
authors.affiliation: Department of Pathophysiology, University of Split School of Medicine, Split, Croatia.
authors.forename: Josko
authors.initials: J
authors.lastname: Bozic
authors.affiliation: Split Sleep Medicine Center, University of Split School of Medicine, Split, Croatia.|Department of Neuroscience, University of Split School of Medicine, Split, Croatia.
authors.forename: Renata
authors.initials: R
authors.lastname: Pecotic
authors.affiliation: Split Sleep Medicine Center, University of Split School of Medicine, Split, Croatia.
authors.forename: Natalija
authors.initials: N
authors.lastname: Ivkovic
authors.affiliation: Split Sleep Medicine Center, University of Split School of Medicine, Split, Croatia.|Department of Neuroscience, University of Split School of Medicine, Split, Croatia.
authors.forename: Maja
authors.initials: M
authors.lastname: Valic
authors.affiliation: Split Sleep Medicine Center, University of Split School of Medicine, Split, Croatia.|Department of Neuroscience, University of Split School of Medicine, Split, Croatia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Dogas
mesh_terms: D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009968:Orthodontic Appliances, Removable; D011597:Psychomotor Performance; D011788:Quality of Life; D020181:Sleep Apnea, Obstructive / Q000523:psychology / Q000628:therapy*; D011795:Surveys and Questionnaires
keywords: cognitive; mandibular advancement device; obstructive sleep apnea; oral appliances; psychomotor; quality of life; sleepiness