title: [Protective Effect of Component Compatibility Sini Decoction on Hypothyroidism Induced Renal Damage in Rats].
abstract: OBJECTIVE
  To investigate the protective effect of component compatibility Sini Decoction on hypothyroidism induced renal damage in rats.
  
  
  METHODS
  The hypothyroidism model were established by 0.1% propylthiouracil (PTU) solution 10 m/kg for consecutive 15 days. Rats were randomly divided into model group, component compatibility Sini Decoction groups[ CSD 9. 6,4. 8 and 2. 4 g/ (kg · d)] and positive control group [Euthyrox 9 µg/(kg · d)]. Radioimmunoassay was used to determine the serum T3 and T4 levels; serum BUN content was detected by UV spectrophotometer and ELISA method were used to measure the CYS-C content. The kidney was weighed, and the pathological changes of the renal were detected by HE stain.
  
  
  RESULTS
  Compared with blank control group, kidney weight coefficient, serum T3 and T4 levels in model group were decreased, while serum BUN and CYS-C contents were increased (P < 0.05 or P < 0.01). Compared with model group, serum T3 and T4 contents were increased and serum BUN and CYS-C contents were decreased (P < 0.05) in Sini Decoction groups [CSD 9.6 and 4.8 g/(kg · d)] and positive control group. The HE stain results showed that component compatibility Sini Decoction and Euthyrox could relieve glomerular atrophy and renal tubular epithelial cell injury in rats.
  
  
  CONCLUSIONS
  Component compatibility Sini Decoction has a curative effect on hypothyroidism induced renal damage in rats.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Miao-rong
authors.initials: MR
authors.lastname: Pei
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007037:Hypothyroidism / Q000150:complications*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; C478756:sini tang; D013974:Thyroxine