title: Role of complement in glomerular diseases.
abstract: The complement system, composed of nearly 30 proteins, is a key regulator of immunity. The complement system is critical for protecting hosts from invading pathogens. Dysregulation of this system is associated with susceptibility to infection and various autoimmune diseases. Furthermore, complement activation due to the defective regulation of the alternative pathway will induce glomerular diseases. Anti-complement therapy has been applied in various glomerular diseases. Signaling pathways might be very important in the pathogenesis of glomerular diseases. This review will give a relatively complete signaling pathway flowchart for complement and a comprehensive understanding of the underlying role of complement in glomerular diseases.
authors.affiliation: a Department of Pediatrics , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , P.R. China.
authors.forename: Song
authors.initials: S
authors.lastname: Mao
authors.affiliation: a Department of Pediatrics , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , P.R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000473:pathology*; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D003165:Complement System Proteins
keywords: Complement; glomerular diseases; signaling pathways