title: TriGlycerides and high-density lipoprotein cholesterol ratio compared with homeostasis model assessment insulin resistance indexes in screening for metabolic syndrome in the chinese obese children: a cross section study.
abstract: BACKGROUND
  Metabolic Syndrome (MS) is prevalant in China, especially according to the pediatric obesity group. Based on the MS-CHN2012 definition for Chinese children and adolescents the need to explore and establish a convienent MS screening become imminent. This study aims to investigate the optimal cut-off values, compare the accuracy for the (TriGlycerides (TG) to High-Density Lipoprotein Cholesterol (HDL-C)) (TG/HDL-C) ratio and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) indexs to identify Metabolic Syndrome in obese pediatric population in China.
  
  
  METHODS
  A total sample of 976 children (female 286 male 690, BMI > = 95 percentile) aged from 6-16 years underwent a medical assessment including a physical examination and investigations of total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, insulin, glucose, and oral glucose tolerance test to identify the components of Metabolic Syndrome. The validity and accuracy between TG/HDL-C ratio and HOMA-IR were compared by Receiver Operating Characteristics analysis (ROC).
  
  
  RESULTS
  TG/HDL-C ratio achieved a larger ROC Area under Curve (AUC = 0.843) than HOMA-IR indexes (0.640, 0.625 for HOMA1-IR, HOMA2-IR respectively) to screen for Metabolic Syndrome. The cut-off values for MS were: TG/HDL-C ratio > 1.25 (sensitivity: 80%; specificity: 75%), HOMA1-IR > 4.59 (sensitivity: 58.7%; specificity: 65.5%) and HOMA2-IR > 2.76 (sensitivity: 53.2%; specificity: 69.5%). The results kept robust after stratified by gender, age group and pubertal stage.
  
  
  CONCLUSIONS
  TG/HDL-C ratio was a better indicator than the HOMA-IR to screen for a positive diagnosis for MS. Furthermore, the TG/HDL-C ratio was superior to the HOMA-IR indexes even after the control of possible confusions from the gender, age group and puberty stage.
  
  
  CONCLUSIONS
  TG/HDL-C ratio proved a better index than HOMA-IR in screening for MS in obese children and adolescents. TG/HDL-C ratio has a discriminatory power in detecting potential MS in the Chinese obese pediatric population.
authors.affiliation: Biostatistics Unit of the Children's Hospital, Zhejiang University, School of Medicine, Hangzhou, 310003, China. LIANGJIANFENG@ZJU.EDU.CN.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liang
authors.affiliation: Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. fjf68@qq.com.
authors.forename: Junfen
authors.initials: J
authors.lastname: Fu
authors.affiliation: Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. jiangyoujun888@163.com.
authors.forename: Youyun
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. dgpxlx@163.com.
authors.forename: Guanping
authors.initials: G
authors.lastname: Dong
authors.affiliation: Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. wangxiumin1019@126.com.
authors.forename: Xiumin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. wuwei120@sina.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis*; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D014280:Triglycerides