title: Patients' satisfaction with therapy methods of advanced chronic venous disease.
abstract: BACKGROUND
  To assess patients' satisfaction from the therapy of advanced chronic venous disorders (CVD) in everyday clinical practice in Poland, and to compare the efficacy of various venoactive drugs (VADs) in venous ulcers healing process.
  
  
  METHODS
  Seven hundred and eighty unselected adult patients with active (N.=441) or healed (N.=339) venous ulcers participated in the non-interventional observational 6-week study.
  
  
  RESULTS
  Compression therapy and VADs were utilized by 81.5% and 89.2% of patients respectively: 31.2% of all patients underwent surgical procedures for vein incompetence, 61.3% were satisfied with surgical methods, 43% with compression therapy, and 32.6% with VADs ‑ with highest rate of satisfied patients in the group taking Ruscus aculeatus and HMC and ascorbic acid (51.4%). Of 377 patients with active venous ulcers smaller than 200 cm2, adherent to VADs, 18.0% have been cured, and 66.6% have improved during 6-week period of observation. Multiple logistic regression analysis revealed that the compression therapy (OR=2.74), the size of ulcer ≤10 cm2 (OR=2.70) were increasing the change of ulcer healing. No VADs was better than another in the healing process.
  
  
  CONCLUSIONS
  1) Compression therapy and VADs are highly utilized by patients with advanced CVD. 2) Patients are more satisfied with surgical than conservative treatment of advanced CVD. 3) More than half of the patients with the advanced stage CVD taking Ruscus aculeatus and HMC and ascorbic acid is satisfied with the obtained improvement. 4) Ruscus aculeatus and HMC and ascorbic acid is similarly effective as other frequently used VADs in venous ulcer healing. 5) Ruscus aculeatus and HMC and ascorbic acid exerting effects on veins, capillaries and lymphatic vessels may explain the positive results observed in this study.
authors.affiliation: Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland - chj@poczta.fm.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Chudek
authors.forename: Jacek
authors.initials: J
authors.lastname: Mikosiński
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kobielski
authors.forename: Artur
authors.initials: A
authors.lastname: Hering
authors.forename: Tomasz
authors.initials: T
authors.lastname: Aleksiejew-Kleszczyński
authors.forename: Jacek
authors.initials: J
authors.lastname: Umiński
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zubilewicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kobusiewicz
authors.forename: Marek
authors.initials: M
authors.lastname: Iłżecki
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wojtak
authors.forename: Janusz
authors.initials: J
authors.lastname: Stec
authors.forename: Tomasz
authors.initials: T
authors.lastname: Urbanek
mesh_terms: D000368:Aged; D001205:Ascorbic Acid / Q000627:therapeutic use*; D047188:Chalcones / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D006569:Hesperidin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D031443:Ruscus; D012720:Severity of Illness Index; D014647:Varicose Ulcer / Q000188:drug therapy*; D014945:Wound Healing
chemical_list: D047188:Chalcones; D010936:Plant Extracts; C033022:hesperidin methylchalcone; D006569:Hesperidin; D001205:Ascorbic Acid