title: Synthesis and base pairing studies of geranylated 2-thiothymidine, a natural variant of thymidine.
abstract: The synthesis and base pairing of DNA duplexes containing the geranylated 2-thiothymidine have been investigated. This naturally existing hydrophobic modification could grant better base pairing stability to the T-G pair over normal T-A and other mismatched pairs in the duplex context. This study provides a potential explanation for the different codon recognition preferences of the geranylated tRNAs.
authors.affiliation: Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA. jsheng@albany.edu and The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA.
authors.forename: Srivathsan V
authors.initials: SV
authors.lastname: Ranganathan
authors.affiliation: The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Basanta-Sanchez
authors.affiliation: Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA. jsheng@albany.edu and The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA.
authors.forename: Fusheng
authors.initials: F
authors.lastname: Shen
authors.affiliation: Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA. jsheng@albany.edu and The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Chen
authors.affiliation: Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA. jsheng@albany.edu and The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Sheng
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D056004:Molecular Dynamics Simulation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013729:Terpenes / Q000138:chemical synthesis*; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D009838:Oligodeoxyribonucleotides; D013729:Terpenes; D013936:Thymidine