title: Kinases as targets for chemical modulators: Structural aspects and their role in spermatogenesis.
abstract: Protein phosphorylation and de-phosphorylation events are crucial in deciding the fate of cells. They regulate cellular growth, differentiation and cell death, and kinases are the key players of these events. The members of ser/thr kinases and tyrosine kinases form the majority of protein kinase family, exerting their regulatory mechanism in almost all cells. In testis, they impact signal transduction events, regulate all stages of sperm development from mitosis through fertilization. Understanding the function of these kinases at the structural level and studying their interactions with inhibitors can help in understanding the machinery of spermatogenesis. In view of this, we have reviewed some of the prominent kinases that are known to play a role in spermatogenesis. A better understanding of the impacts of kinase inhibition on spermatogenesis should aid in the interpretation of lesions and hopefully further the development of more efficient and potent drug candidates.
authors.affiliation: Centre for Bioinformatics; School of Life Sciences; Pondicherry University ; Puducherry, India.
authors.forename: Pranitha
authors.initials: P
authors.lastname: Jenardhanan
authors.affiliation: Centre for Bioinformatics; School of Life Sciences; Pondicherry University ; Puducherry, India ; Department of Biochemistry & Molecular Biology; School of Life Sciences; Pondicherry University ; Puducherry, India ; KIIT University ; Bhubaneshwar, Odisha, India.
authors.forename: Premendu P
authors.initials: PP
authors.lastname: Mathur
keywords: PTKs; kinase inhibitors; receptor-ligand interactions; signal transduction in spermatogenesis; testis specific kinases