title: Targeted Chemotherapy in Bone and Soft-Tissue Sarcoma.
abstract: Historically surgical intervention has been the mainstay of therapy for bone and soft-tissue sarcomas, augmented with adjuvant radiation for local control. Although cytotoxic chemotherapy revolutionized the treatment of many sarcomas, classic treatment regimens are fraught with side effects while outcomes have plateaued. However, since the approval of imatinib in 2002, research into targeted chemotherapy has increased exponentially. With targeted therapies comes the potential for decreased side effects and more potent, personalized treatment options. This article reviews the evolution of medical knowledge regarding sarcoma, the basic science of sarcomatogenesis, and the major targets and pathways now being studied.
authors.affiliation: Department of Orthopaedics, The Ohio State University, 725 Prior Hall, 376 West 10 Avenue, Columbus, OH 43210, USA.
authors.forename: Jared L
authors.initials: JL
authors.lastname: Harwood
authors.affiliation: Department of Orthopaedics, The Ohio State University, 725 Prior Hall, 376 West 10 Avenue, Columbus, OH 43210, USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Alexander
authors.affiliation: Department of Orthopaedics, The Ohio State University, 725 Prior Hall, 376 West 10 Avenue, Columbus, OH 43210, USA. Electronic address: Joel.Mayerson@osumc.edu.
authors.forename: Joel L
authors.initials: JL
authors.lastname: Mayerson
authors.affiliation: Department of Orthopaedics, The Ohio State University, 725 Prior Hall, 376 West 10 Avenue, Columbus, OH 43210, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Scharschmidt
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics; D006801:Humans; D058990:Molecular Targeted Therapy; D012509:Sarcoma / Q000188:drug therapy* / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents
keywords: Bone; Chemotherapy; Sarcoma; Targeted; Tumor