title: Subetta Enhances Sensitivity of Human Muscle Cells to Insulin.
abstract: Addition of Subetta to insulin (10 nM) increased insulin-stimulated glucose uptake 43% (p<0.001). Moreover, glucose uptake stimulated by insulin (10 nM) in the presence of Subetta was similar to that stimulated by 300 nM insulin. These findings suggest that Subetta significantly enhanced insulin sensitivity of tissues through stimulation of glucose transport to myocytes mediated by glucose transporter 4.
authors.affiliation: Materia Medica Holding, Moscow, Russia. gorbunovea@materiamedica.ru.|Zen-Bio, Inc., Chapel Hill, North Carolina, USA. gorbunovea@materiamedica.ru.
authors.forename: E A
authors.initials: EA
authors.lastname: Gorbunov
authors.affiliation: Zen-Bio, Inc., Chapel Hill, North Carolina, USA.
authors.forename: J
authors.initials: J
authors.lastname: Nicoll
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Myslivets
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Kachaeva
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Tarasov
mesh_terms: D000328:Adult; D000906:Antibodies / Q000494:pharmacology*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000906:Antibodies; D007004:Hypoglycemic Agents; D007328:Insulin; C000608938:subetta; D005947:Glucose
keywords: Subetta; glucose uptake; insulin receptor; release-activity