title: The Role of Cell Plasticity in Tissue Repair: Adaptive Cellular Reprogramming.
abstract: It is becoming clear that a radical change of cell identity of differentiated cells in vivo, triggered by injury or other adversity, provides an essential route to recovery for many different mammalian tissues. This process, which we term adaptive cellular reprogramming, promotes regeneration in one of two ways: by providing a transient class of repair cells or by directly replacing cells lost during tissue damage. Controlling adaptive changes in cell fate in vivo in order to promote the body's own cell therapy, particularly by pharmacology rather than genetics, is likely to become an increasingly active area of future work.
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: k.jessen@ucl.ac.uk.
authors.forename: Kristjan R
authors.initials: KR
authors.lastname: Jessen
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Rhona
authors.initials: R
authors.lastname: Mirsky
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Arthur-Farraj
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D000066670:Cell Plasticity; D065150:Cellular Reprogramming / Q000502:physiology*; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D014945:Wound Healing