title: Cardiovascular drug determination in bioanalysis: an update.
abstract: The great impact of cardiovascular diseases in human health has led to the development of a huge number of drugs and therapies to improve the treatment of these diseases. Cardiovascular drug analysis in biological fluids constitutes an important challenge for analytical scientists. There is a clear need for reliable methods to carry out both qualitative and quantitative analysis in a short time of analysis. Different problems such as drug monitoring, analysis of metabolites, study of drugs interactions, drugs residues or degradation products, chiral separation, and screening and confirmation of drugs of abuse in doping control must be solved. New trends in sample preparation, instrumental and column technology advances in LC and innovations in MS are described in this work.
authors.affiliation: Department of Analytical Chemistry, Faculty of Science & Technology, University of the Basque Country (UPV/EHU), 48080 Bilbao, Basque Country, Spain.
authors.forename: Oskar
authors.initials: O
authors.lastname: González
authors.affiliation: Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University Frankfurt, D-60590 Frankfurt am Main, Germany.
authors.forename: Nerea
authors.initials: N
authors.lastname: Ferreirós
authors.affiliation: Department of Analytical Chemistry, Faculty of Science & Technology, University of the Basque Country (UPV/EHU), 48080 Bilbao, Basque Country, Spain.
authors.forename: María Encarnación
authors.initials: ME
authors.lastname: Blanco
authors.affiliation: Department of Analytical Chemistry, Faculty of Science & Technology, University of the Basque Country (UPV/EHU), 48080 Bilbao, Basque Country, Spain.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Alonso