title: Analysis of vascular endothelial dysfunction genes and related pathways in obesity through systematic bioinformatics.
abstract: Obesity has become an increasingly serious health problem and popular research topic. It is associated with many diseases, especially cardiovascular disease (CVD)-related endothelial dysfunction. This study analyzed genes related to endothelial dysfunction and obesity and then summarized their most significant signaling pathways. Genes related to vascular endothelial dysfunction and obesity were extracted from a PubMed database, and analyzed by STRING, DAVID, and Gene-Go Meta-Core software. 142 genes associated with obesity were found to play a role in endothelial dysfunction in PubMed. A significant pathway (Angiotensin system maturation in protein folding and maturation) associated with obesity and endothelial dysfunction was explored. The genes and the pathway explored may play an important role in obesity. Further studies about preventing vascular endothelial dysfunction obesity should be conducted through targeting these loci and pathways.
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou 215006, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Qiuqin
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Hou
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Yueyue
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Qian
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Lv
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism*; D019295:Computational Biology / Q000379:methods; D004730:Endothelium, Vascular / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D009323:Natural Language Processing; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction; D049490:Systems Biology / Q000379:methods
chemical_list: D020543:Proteome
keywords: Pathway; obesity; system biology; vascular endothelial function