title: The correlation analysis of tumor necrosis factor-alpha-308G/A polymorphism and venous thromboembolism risk: A meta-analysis.
abstract: OBJECTIVE
  Venous thromboembolism is a common complex disorder, being the resultant of gene-gene and gene-environment interactions. Tumor necrosis factor-alpha is a proinflammatory cytokine which has been implicated in venous thromboembolism risk. A promoter 308G/A polymorphism in the tumor necrosis factor-alpha gene has been suggested to modulate the risk for venous thromboembolism. However, the published findings remain inconsistent.
  
  
  METHODS
  In this study, we conducted a meta-analysis of all available data regarding this issue. Eligible studies were identified through search of Pubmed, EBSCO Medline, Web of Science, and China National Knowledge Infrastructure (CNKI, Chinese) databases up to June 2014. Pooled Odd ratios (ORs) with 95% confidence intervals were applied to estimating the strength of the genetic association in the random-effects model or fixed-effects model.
  
  
  RESULTS
  A total of 10 studies involving 1999 venous thromboembolism cases and 2166 controls were included in this meta-analysis to evaluate the association between tumor necrosis factor-alpha-308G/A polymorphism and venous thromboembolism risk. Overall, no significantly increased risk venous thromboembolism was observed in all comparison models when all studies were pooled into the meta-analysis. However, in stratified analyses by ethnicity, there was a pronounced association with venous thromboembolism risk among West Asians in three genetic models (A vs. G: OR = 1.82, 95%CI = 1.13-2.94; GA vs. GG: OR = 1.82, 95%CI = 1.08-3.06; AA/GA vs. GG: OR = 1.88, 95%CI = 1.12-3.16). When stratifying by source of controls, no significant result was detected in all genetic models.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that tumor necrosis factor-alpha 308G/A polymorphism may contribute to susceptibility to venous thromboembolism among West Asians. Studies are needed to ascertain these findings in larger samples and different racial groups.
authors.affiliation: Department of Hepatobiliary Surgery, First People's Hospital of Wujiang District, Suzhou, Jiangsu, P.R. China.
authors.forename: Quangen
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, P.R. China.
authors.forename: Peijin
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, P.R. China.
authors.forename: He
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, P.R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Tong
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, P.R. China L23zj@163.com.
authors.forename: Zhaojun
authors.initials: Z
authors.lastname: Lu
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D054556:Venous Thromboembolism / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Tumor necrosis factor-alpha; meta-analysis; polymorphism; venous thromboembolism