title: LucKi Birth Cohort Study: rationale and design.
abstract: BACKGROUND
  Infancy and childhood are characterized by rapid growth and development, which largely determine health status and well-being across the lifespan. Identification of modifiable risk factors and prognostic factors in critical periods of life will contribute to the development of effective prevention and intervention strategies. The LucKi Birth Cohort Study was designed and started in 2006 to follow children from birth into adulthood on a wide range of determinants, disorders, and diseases. During preschool and school years, the primary focus is on the etiology and prognosis of atopic diseases (eczema, asthma, and hay fever) and overweight/obesity.
  
  
  METHODS
  LucKi is an ongoing, dynamic, prospective birth cohort study, embedded in the Child and Youth Health Care (CYHC) practice of the 'Westelijke Mijnstreek' (a region in the southeast of the Netherlands). Recruitment (1-2 weeks after birth) and follow-up (until 19 years) coincide with routine CYHC contact moments, during which the child's physical and psychosocial development is closely monitored, and anthropometrics are measured repeatedly in a standardised way. Information gathered through CYHC is complemented with repeated parental questionnaires, and information from existing registries of pharmacy, hospital and/or general practice. Since the start already more than 5,000 children were included in LucKi shortly after birth, reaching an average participation rate of ~65 %.
  
  
  CONCLUSIONS
  The LucKi Birth Cohort Study provides a framework in which children are followed from birth into adulthood. Embedding LucKi in CYHC simplifies implementation, leads to low maintenance costs and high participation rates, and facilitates direct implementation of study results into CYHC practice. Furthermore, LucKi provides opportunities to initiate new (experimental) studies and/or to establish biobanking in (part of) the cohort, and contributes relevant information on determinants and health outcomes to policy and decision makers. Cohort details can be found on www.birthcohorts.net .
authors.affiliation: Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands. dianne.dekorte@maastrichtuniversity.nl.
authors.forename: Dianne
authors.initials: D
authors.lastname: de Korte-de Boer
authors.affiliation: Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands. monique.mommers@maastrichtuniversity.nl.
authors.forename: Monique
authors.initials: M
authors.lastname: Mommers
authors.affiliation: Department of Youth Health Care, South Limburg Public Health Service, Geleen, The Netherlands. huub.creemers@ggdzl.nl.
authors.forename: Huub M H
authors.initials: HM
authors.lastname: Creemers
authors.affiliation: Department of Paediatric Respiratory Medicine, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands. edward.dompeling@mumc.nl.
authors.forename: Edward
authors.initials: E
authors.lastname: Dompeling
authors.affiliation: Department of Social Medicine, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands. f.feron@maastrichtuniversity.nl.
authors.forename: Frans J M
authors.initials: FJ
authors.lastname: Feron
authors.affiliation: Department of Environmental Health, South Limburg Public Health Service, Geleen, The Netherlands. cindy.gielkens@ggdzl.nl.
authors.forename: Cindy M L
authors.initials: CM
authors.lastname: Gielkens-Sijstermans
authors.affiliation: Orbis Child and Youth Health Care, Orbis Medical Concern, Sittard, The Netherlands. m.jaminon@orbisconcern.nl.
authors.forename: Mariëlle
authors.initials: M
authors.lastname: Jaminon
authors.affiliation: Department of Research and Development, South Limburg Public Health Service, Geleen, The Netherlands. suhreta.mujakovic@ggdzl.nl.
authors.forename: Suhreta
authors.initials: S
authors.lastname: Mujakovic
authors.affiliation: Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands. onno.vanschayck@maastrichtuniversity.nl.
authors.forename: Onno C P
authors.initials: OC
authors.lastname: van Schayck
authors.affiliation: Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands. c.thijs@maastrichtuniversity.nl.
authors.forename: Carel
authors.initials: C
authors.lastname: Thijs
authors.affiliation: Department of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands. maria.jansen@ggdzl.nl.
authors.forename: Maria
authors.initials: M
authors.lastname: Jansen
mesh_terms: D000293:Adolescent; D000067697:Adolescent Health / Q000706:statistics & numerical data*; D001249:Asthma / Q000453:epidemiology; D002648:Child; D002657:Child Development; D000067576:Child Health / Q000706:statistics & numerical data*; D002675:Child, Preschool; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology*; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology; D006801:Humans; D008297:Male; D009426:Netherlands; D063766:Pediatric Obesity / Q000453:epidemiology*; D011446:Prospective Studies