title: The role of fatty acids in insulin resistance.
abstract: Insulin resistance is a multi-faceted disruption of the communication between insulin and the interior of a target cell. The underlying cause of insulin appears to be inflammation that can either be increased or decreased by the fatty acid composition of the diet. However, the molecular basis for insulin resistance can be quite different in various organs. This review deals with various types of inflammatory inputs mediated by fatty acids, which affect the extent of insulin resistance in various organs.
authors.affiliation: Inflammation Research Foundation, 200 Corporate Place, Peabody, MA, 01960, USA. BSears@drsears.com.
authors.forename: Barry
authors.initials: B
authors.lastname: Sears
authors.affiliation: Inflammation Research Foundation, 200 Corporate Place, Peabody, MA, 01960, USA. MPerry@zoneliving.com.
authors.forename: Mary
authors.initials: M
authors.lastname: Perry
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D005227:Fatty Acids / Q000008:administration & dosage / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051550:I-kappa B Kinase / Q000235:genetics / Q000378:metabolism; D007249:Inflammation; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D007333:Insulin Resistance; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D048670:MAP Kinase Kinase 4 / Q000235:genetics / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D007328:Insulin; D014409:Tumor Necrosis Factor-alpha; D051550:I-kappa B Kinase; D048670:MAP Kinase Kinase 4