title: Degradable polymeric nanoparticles by aggregation of thermoresponsive polymers and "click" chemistry.
abstract: This study describes a novel approach to the preparation of crosslinked polymeric nanoparticles of controlled sizes that can be degraded under basic conditions. For this purpose thermoresponsive copolymers containing azide and alkyne functions were obtained by ATRP of di(ethylene glycol) monomethyl ether methacrylate (D) and 2-aminoethyl methacrylate (A) followed by post polymerization modification. The amino groups of A were reacted with propargyl chloroformate or 2-azido-1,3-dimethylimidazolinium hexafluorophosphate, which led to two types of copolymers. Increasing the temperature of aqueous solutions of the mixed copolymers caused their aggregation into spherical nanoparticles composed of both types of chains. Their dimensions could be controlled by changing the concentration and heating rate of the solutions. Covalent stabilization of aggregated chains was performed by a "click" reaction between the azide and alkyne groups. Due to the presence of a carbamate bond the nanoparticles undergo pH dependent degradation under mild basic conditions. The proposed procedure opens a route to new carriers for the controlled release of active species.
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland. adworak@cmpw-pan.edu.pl.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dworak
authors.forename: Daria
authors.initials: D
authors.lastname: Lipowska
authors.forename: Dawid
authors.initials: D
authors.lastname: Szweda
authors.forename: Jerzy
authors.initials: J
authors.lastname: Suwinski
authors.forename: Barbara
authors.initials: B
authors.lastname: Trzebicka
authors.forename: Roza
authors.initials: R
authors.lastname: Szweda