title: Quercetin does not alter the oral bioavailability of Atorvastatin in rats.
abstract: The study was undertaken to evaluate the effect of Quercetin on the pharmacokinetics of Atorvastatin Calcium. In-vivo Pharmacokinetic studies were performed on rats in a single dose study and multiple dose study. Rats were treated with Quercetin (10 mg/kg) and Atorvastatin Calcium (20 mg/kg) orally and blood samples were collected at (0) pretreatment and 0.5, 1, 1.5, 2, 2.5, 3, 4, 8, 12, 24 hours post treatment. Plasma concentrations of Atorvastatin were estimated by HPLC method. Quercetin treatment did not significantly alter the pharmacokinetic parameters of atorvastatin like AUC(0-24), AUC(0-α) , T(max), C(max) and T(½) in both single dose and multiple dose studies of Atorvastatin Calcium. Quercetin does not alter the oral bioavailability of Atorvastatin Calcium in rats.
authors.affiliation: Department of Pharmacology, AMR Memorial College of Pharmacy, Narasarao Pet, Guntur, India.
authors.forename: Rekha
authors.initials: R
authors.lastname: Koritala
authors.affiliation: Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India.
authors.forename: Siva Reddy
authors.initials: SR
authors.lastname: Challa
authors.affiliation: Department of Pharmacology, AMR Memorial College of Pharmacy, Narasarao Pet, Guntur, India.
authors.forename: Satheesh Kumar
authors.initials: SK
authors.lastname: Ragam
authors.affiliation: Department of Pharmacology, AMR Memorial College of Pharmacy, Narasarao Pet, Guntur, India.
authors.forename: Lal Babu
authors.initials: LB
authors.lastname: Geddam
authors.affiliation: Department of Pharmacology, AMR Memorial College of Pharmacy, Narasarao Pet, Guntur, India.
authors.forename: Venkatesh Reddy
authors.initials: VR
authors.lastname: Venkatesh Reddy Challa
authors.affiliation: Department of Pharmacology, AMR Memorial College of Pharmacy, Narasarao Pet, Guntur, India.
authors.forename: Renuka
authors.initials: R
authors.lastname: Devi
authors.affiliation: Department of Pharmacology, AMR Memorial College of Pharmacy, Narasarao Pet, Guntur, India.
authors.forename: Srinu
authors.initials: S
authors.lastname: Sattenapalli
authors.affiliation: Director, Cystron Pharmaceutical Laboratories, Autonagar, Vijayawada, India.
authors.forename: Narendra
authors.initials: N
authors.lastname: Babu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000069059:Atorvastatin / Q000493:pharmacokinetics*; D001682:Biological Availability; D002138:Calibration; D051544:Cytochrome P-450 CYP3A / Q000502:physiology; D004347:Drug Interactions; D005260:Female; D008297:Male; D029362:Organic Anion Transporters, Sodium-Independent / Q000502:physiology; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D029362:Organic Anion Transporters, Sodium-Independent; C421102:Slco1a1 protein, rat; D011794:Quercetin; D000069059:Atorvastatin; C465260:Cyp3a2 protein, rat; D051544:Cytochrome P-450 CYP3A