title: Gender differences in the association between hyperuricemia and diabetic kidney disease in community elderly patients.
abstract: OBJECTIVE
  To investigate gender differences of the associations between hyperuricemia and diabetic kidney disease (DKD) in elderly patients with type 2 diabetes mellitus (T2DM) based on electronic health records (EHR).
  
  
  METHODS
  A total of 20,207 older diabetic patients (mean age 71±7years) were investigated based on the EHR from 2012 to 2013 in the Minhang District of Shanghai-China. The status of hyperuricemia, albuminuric DKD and the odds ratios of DKD relative to hyperuricemia were analyzed among 8541 men and 11,666 women.
  
  
  RESULTS
  The overall rate of hyperuricemia was 20.5% (males: 17.2%, females: 23.0%) and that of albuminuric DKD was 36.2% (males: 32.2%, female: 39.1%) in these diabetic patients. Hyperuricemia was independently associated with increased risk of reduced renal function and albuminuria (p<0.001) in both genders. After adjustment of traditional DKD risk factors, hyperuricemia had a stronger association with albuminuric DKD in males (OR 1.67, 95% CI: 1.48-1.88) than in females (OR 1.23, 95% CI: 1.12-1.35).
  
  
  CONCLUSIONS
  This study showed an independent association of hyperuricemia with albuminuric DKD that was stronger in elderly males for the first time in China based on EHR. The level of uric acid should be monitored and managed in older diabetic patients.
authors.affiliation: Fifth People's Hospital, Fudan University, No. 128 Ruili Road,Minhang District, Shanghai 200240, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Guo
authors.affiliation: Fifth People's Hospital, Fudan University, No. 128 Ruili Road,Minhang District, Shanghai 200240, China.
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Niu
authors.affiliation: Fifth People's Hospital, Fudan University, No. 128 Ruili Road,Minhang District, Shanghai 200240, China.
authors.forename: She-Ran
authors.initials: SR
authors.lastname: Li
authors.affiliation: Fifth People's Hospital, Fudan University, No. 128 Ruili Road,Minhang District, Shanghai 200240, China.
authors.forename: Xian-Wu
authors.initials: XW
authors.lastname: Ye
authors.affiliation: Center for Disease Prevention and Control of Minhang District, No. 965 Zhongyi Road, Shanghai 201101, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Fang
authors.affiliation: Fifth People's Hospital, Fudan University, No. 128 Ruili Road,Minhang District, Shanghai 200240, China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Zhao
authors.affiliation: Fifth People's Hospital, Fudan University, No. 128 Ruili Road,Minhang District, Shanghai 200240, China; Department of Nephrology, Huashan Hospital, Fudan University, No. 12 Wulumuqi Road, Shanghai 200040, China. Electronic address: yonggu@vip.163.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Gu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000419:Albuminuria / Q000209:etiology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000652:urine; D003928:Diabetic Nephropathies / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D057286:Electronic Health Records; D004812:Epidemiologic Methods; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000453:epidemiology; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D051437:Renal Insufficiency / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D012306:Risk; D012720:Severity of Illness Index; D012737:Sex Factors
keywords: Community; Diabetic kidney disease; Elderly; Gender; Hyperuricemia