title: New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation.
abstract: New series of hydrazones 5-18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram (+), Gram (-) bacteria and one fungal strain. Tested molecules displayed moderate-to-good growth inhibition activity. 2,2-Diphenyl-1-picrylhydrazide assay was used to test the antioxidant properties of the compounds. Monohydroxy (14-16), para-fluorine (13) and 2,4-dichlorine (17) derivatives exhibited better free-radical scavenging ability than the other investigated molecules.
authors.affiliation: Department of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. cmoldovan@umfcluj.ro.
authors.forename: Cristina
authors.initials: C
authors.lastname: Nastasă
authors.affiliation: Department of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. brandu32@yahoo.com.
authors.forename: Brîndușa
authors.initials: B
authors.lastname: Tiperciuc
authors.affiliation: State Veterinary Laboratory for Animal Health and Safety, 1 Piața Mărăști Street, 400609 Cluj-Napoca, Romania. duma.mihaelacj@yahoo.com.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Duma
authors.affiliation: Department of Pharmacognosy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj-Napoca, Romania. dbenedec@umfcluj.ro.
authors.forename: Daniela
authors.initials: D
authors.lastname: Benedec
authors.affiliation: Department of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. onigao65@yahoo.com.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Oniga
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D006835:Hydrazones
keywords: acyl-hydrazone; antibacterial; antifungal; antioxidant; hydrazide; thiazole