title: Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C.
abstract: OBJECTIVE
  To evaluate the changes of shear-wave velocity (Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C.
  
  
  METHODS
  Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon (IFN) plus ribavirin (RBV). Vs value (m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment (EOT), 1 year after EOT, and 2 years after EOT.
  
  
  RESULTS
  In patients with a sustained virological response (SVR) (n = 41), Vs significantly decreased at EOT [1.19 (1.07-1.37), P = 0.0004], 1 year after EOT [1.10 (1.00-1.22), P = 0.0001], and 2 years after EOT [1.05 (0.95-1.16), P < 0.0001] compared with baseline [1.27 (1.11-1.49)]. In patients with a relapse (n = 26), Vs did not significantly decrease at EOT [1.23 (1.12-1.55)], 1 year after EOT [1.20 (1.12-1.80)], and 2 years after EOT [1.41 (1.08-2.01)] compared with baseline [1.39 (1.15-1.57)]. In patients with a nonvirological response (n = 20), Vs did not significantly decrease at EOT [1.64 (1.43-2.06)], 1 year after EOT [1.66 (1.30-1.95)], and 2 years after EOT [1.61 (1.36-2.37)] compared with baseline [1.80 (1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28 (1.04-1.40)] than in non-SVR patients [1.56 (1.20-1.83)] (P = 0.0142).
  
  
  CONCLUSIONS
  Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Osakabe
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Ichino
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Nishikawa
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sugiyama
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Kato
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Ai
authors.initials: A
authors.lastname: Shibata
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Wakana
authors.initials: W
authors.lastname: Asada
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kawabe
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Senju
authors.initials: S
authors.lastname: Hashimoto
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Michihito
authors.initials: M
authors.lastname: Murao
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Nakano
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimazaki
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kan
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nakaoka
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Takagawa
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Ohki
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Kurashita
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Takamura
authors.affiliation: Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yoshioka
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D054459:Elasticity Imaging Techniques; D005260:Female; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D011994:Recombinant Proteins / Q000627:therapeutic use; D012254:Ribavirin / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a
keywords: Fibrosis; Hepatitis C virus; Interferon and ribavirin; Liver stiffness; Shear-wave velocity