title: Changes in the before and after thyroxine treatment levels of adipose tissue, leptin, and resistin in subclinical hypothyroid patients.
abstract: BACKGROUND
  Subclinical hypothyroidism (SH) occurs when serum thyroid stimulating hormone (TSH) concentrations are raised and serum thyroid hormone concentrations are normal. The effect of SH on the proinflammatory adipose cytokine releasing visceral adipose tissue (VAT) is not clear. The aim of this study is to identify the difference between the pre and posttreatment levels of VAT, leptin, and resistin in SH patients.
  
  
  METHODS
  There were 51 SH patients and 43 age- and gender-matched healthy subjects included in the study. Thyroid functions, biochemical tests, leptin, resistin, and visceral and subcutaneous fat measurements were made. The measurements were repeated in the SH group in the third month following L-thyroxin treatment.
  
  
  RESULTS
  Initially, high sensitivity C-reactive protein, carotid artery intima-media thickness (mm), leptin, and resistin levels were significantly higher in the SH group compared to the controls, while the other parameters were similar. While no correlation was observed between TSH levels and adipokines, a positive correlation was detected between waist circumference and leptin levels (r = 0.549, p < 0.01). Visceral adipose tissue was positively correlated to age, waist circumference, and leptin levels, but negatively correlated to free thyroxin (T4) levels (r = 0.419, p = 0.009; r = 0.794, p < 0.01; r = 0.515, p < 0.01 and r = - 0.416, p = 0.009, respectively). A significant decrease was observed in VAT volume, leptin, and resistin levels of SH patients following levothyroxine treatment. Conclusion The reduced VAT volume, leptin, and resistin levels in SH patients following treatment may support the idea that TSH affects adipose tissue functions.
authors.affiliation: Department of Internal Medicine, Endocrinology and Metabolism, Mugla Sıtkı Kocman University School of Medicine, Mugla, Turkey. gulhanakcil@yahoo.com.tr.
authors.forename: Gulhan
authors.initials: G
authors.lastname: Akbaba
authors.affiliation: Clinics of Endocrinology and Diseases of Metabolism, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.affiliation: Clinics of Endocrinology and Diseases of Metabolism, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Isık
authors.affiliation: Clinics of Endocrinology and Diseases of Metabolism, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Mazhar Muslum
authors.initials: MM
authors.lastname: Tuna
authors.affiliation: Clinics of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Suha
authors.initials: S
authors.lastname: Koparal
authors.affiliation: Clinics of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Vural
authors.affiliation: Clinics of Biochemistry, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Fatma Meric
authors.initials: FM
authors.lastname: Yılmaz
authors.affiliation: Clinics of Biochemistry, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Topcuoglu
authors.affiliation: Clinics of Endocrinology and Diseases of Metabolism, Ankara Numune Education and Research Hospital, Ankara, Turkey.|Faculty of Medicine, Department of Endocrinology and Diseases of Metabolism, Hitit University, Corum, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Guler
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000187:drug effects*; D020738:Leptin / Q000097:blood*; D008297:Male; D015203:Reproducibility of Results; D052243:Resistin / Q000097:blood*; D012680:Sensitivity and Specificity; D013974:Thyroxine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D020738:Leptin; D052243:Resistin; D013974:Thyroxine
keywords: Leptin; Resistin; Subclinical hypothyroidism; Thyroid stimulating hormone; Visceral adipose tissue