title: Diastereoselective Synthesis of Dispirobarbiturates through Et3N-Catalyzed [3 + 2] Cycloaddition of Barbiturate-Based Olefins with 3-Isothiocyanato Oxindoles.
abstract: Under catalysis of 10 mol % of Et3N, the [3 + 2] cycloaddition of barbiturate-based olefins with 3-isothiocyanato oxindoles underwent smoothly and afforded the desired dispirobarbiturates in up to 99% yield with up to 99:1 dr. The relative configuration of the dispirobarbiturates was unambiguously determined by X-ray single-crystal structure analysis. The reaction mechanism was proposed to shed light on the diastereoselective formation of the dispirobarbiturates.
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology , Beijing 100124, P. R. China.
authors.forename: Hong-Wu
authors.initials: HW
authors.lastname: Zhao
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology , Beijing 100124, P. R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Tian
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology , Beijing 100124, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology , Beijing 100124, P. R. China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yang
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology , Beijing 100124, P. R. China.
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Pang
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology , Beijing 100124, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Meng
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology , Beijing 100124, P. R. China.
authors.forename: Xiu-Qing
authors.initials: XQ
authors.lastname: Song
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology , Beijing 100124, P. R. China.
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Chen