title: Advanced cell therapies: targeting, tracking and actuation of cells with magnetic particles.
abstract: Regenerative medicine would greatly benefit from a new platform technology that enabled measurable, controllable and targeting of stem cells to a site of disease or injury in the body. Superparamagnetic iron-oxide nanoparticles offer attractive possibilities in biomedicine and can be incorporated into cells, affording a safe and reliable means of tagging. This review describes three current and emerging methods to enhance regenerative medicine using magnetic particles to guide therapeutic cells to a target organ; track the cells using MRI and assess their spatial localization with high precision and influence the behavior of the cell using magnetic actuation. This approach is complementary to the systemic injection of cell therapies, thus expanding the horizon of stem cell therapeutics.
authors.affiliation: UCL Centre of Advanced Biomedical Imaging, Division of Medicine, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
authors.forename: John J
authors.initials: JJ
authors.lastname: Connell
authors.affiliation: UCL Centre of Advanced Biomedical Imaging, Division of Medicine, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
authors.forename: P Stephen
authors.initials: PS
authors.lastname: Patrick
authors.affiliation: UCL Centre of Advanced Biomedical Imaging, Division of Medicine, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
authors.forename: Yichao
authors.initials: Y
authors.lastname: Yu
authors.affiliation: UCL Centre of Advanced Biomedical Imaging, Division of Medicine, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Lythgoe
authors.affiliation: UCL Centre of Advanced Biomedical Imaging, Division of Medicine, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
authors.forename: Tammy L
authors.initials: TL
authors.lastname: Kalber
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D015220:Calcium Channels / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry*; D049452:Green Fluorescent Proteins / Q000737:chemistry; D006801:Humans; D007328:Insulin / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D018613:Microscopy, Confocal; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends; D015203:Reproducibility of Results; D013234:Stem Cells / Q000166:cytology*; D019076:Transgenes
chemical_list: D001786:Blood Glucose; D015220:Calcium Channels; D003911:Dextrans; D005290:Ferric Compounds; D007328:Insulin; D058185:Magnetite Nanoparticles; D049452:Green Fluorescent Proteins; C000499:ferric oxide; C065507:ferumoxides; D002118:Calcium
keywords: MRI; SPION; cell tracking; magnetic actuation; magnetic targeting; regenerative medicine