title: Tonic GABAA Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy.
abstract: Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABAA receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABAA receptors in epilepsy and as potential antiepileptic target will be discussed.
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands. S.Schipper@maastrichtuniversity.nl.|Faculty of Health Medicine and Life Sciences, School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands. S.Schipper@maastrichtuniversity.nl.
authors.forename: S
authors.identifier: 0000-0001-9628-8093
authors.initials: S
authors.lastname: Schipper
authors.affiliation: Faculty of Health Medicine and Life Sciences, School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: M W
authors.initials: MW
authors.lastname: Aalbers
authors.affiliation: Faculty of Health Medicine and Life Sciences, School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.|Department of Neurosurgery and Orthopedic Surgery, Atrium Hospital Heerlen, Heerlen, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Rijkers
authors.affiliation: BIOMED Research Institute, Hasselt University/Transnational University Limburg, Martelarenlaan 42, 3500, Hasselt, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Swijsen
authors.affiliation: BIOMED Research Institute, Hasselt University/Transnational University Limburg, Martelarenlaan 42, 3500, Hasselt, Belgium.
authors.forename: J M
authors.initials: JM
authors.lastname: Rigo
authors.affiliation: Faculty of Health Medicine and Life Sciences, School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.|Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Hoogland
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.|Faculty of Health Medicine and Life Sciences, School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: J S H
authors.initials: JS
authors.lastname: Vles
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D011963:Receptors, GABA-A / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D011963:Receptors, GABA-A
keywords: Antiepileptic drugs; Epilepsy; Extrasynaptic GABAA receptor; Seizures; Tonic