title: Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions.
abstract: In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. The cross-sectional and longitudinal assessment of the temporal and spatial patterns of tau deposition in the brain will allow a better understanding of the role tau plays in ageing as well as its relationship with cognition, genotype, and neurodegeneration. It is likely that selective tau imaging could be used as a diagnostic and prognostic biomarker of disease progression, as well as a surrogate marker for monitoring of efficacy and patient recruitment for disease-specific therapeutic trials.
authors.affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Victoria 3084, Australia; Department of Medicine, The University of Melbourne, Austin Health, Victoria 3084, Australia; The Florey Institute, The University of Melbourne, Victoria 3010, Australia. Electronic address: victorlv@unimelb.edu.au.
authors.forename: Victor L
authors.initials: VL
authors.lastname: Villemagne
authors.affiliation: Department of Pharmacology, Tohoku University School of Medicine, Sendai 980-8575, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Okamura
mesh_terms: D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D020208:Brain Injury, Chronic / Q000000981:diagnostic imaging* / Q000378:metabolism; D057174:Frontotemporal Lobar Degeneration / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D019636:Neurodegenerative Diseases; D059906:Neuroimaging; D011877:Radionuclide Imaging; D013494:Supranuclear Palsy, Progressive / Q000000981:diagnostic imaging / Q000378:metabolism; D024801:Tauopathies / Q000000981:diagnostic imaging* / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins