title: Intraoperative high-field magnetic resonance imaging combined with functional neuronavigation in resection of low-grade temporal lobe tumors.
abstract: BACKGROUND
  The aim of this study is to investigate the role of intraoperative MR imaging in temporal lobe low-grade glioma (LGG) surgery and to report the surgical outcome in our series with regard to seizures, neurological defects, and quality of life.
  
  
  METHODS
  Patients with temporal lobe contrast-nonenhancing gliomas who presented with seizures in the course of their disease were enrolled in our prospective study. We non-randomly assigned patients to undergo intraoperative magnetic resonance imaging (iMRI)-guided surgery or conventional surgery. Extent of resection (EOR) and surgical outcomes were compared between the two groups.
  
  
  RESULTS
  Forty-one patients were allocated in the iMRI group, and 14 were in the conventional group. Comparable EOR was achieved for the two groups (p = 0.634) although preoperative tumor volumes were significantly larger for the iMRI group. Seizure outcome tended to be better for the iMRI group (Engel class I achieved for 89.7% (35/39) vs 75% (9/12)) although this difference was not statistically different. Newly developed neurological deficits were observed in four patients (10.3%) and two patients (16.7%), respectively (p = 0.928). Free of seizures and neurological morbidity led to a return-to-work or return-to-school rate of 84.6% (33/39) vs 75% (9/12), respectively (p = 0.741).
  
  
  CONCLUSIONS
  Our study provided evidence that iMRI was a safe and useful tool in temporal lobe LGG surgery. Optimal extent of resection contributed to favorable seizure outcome in our series with low morbidity rate, which led to a high return-to-work rate.
authors.affiliation: Department of Neurosurgery, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China. bshc890319@gmail.com.
authors.forename: Shao-cong
authors.initials: SC
authors.lastname: Bai
authors.affiliation: Department of Neurosurgery, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China. XuBN010@163.com.
authors.forename: Bai-nan
authors.initials: BN
authors.lastname: Xu
authors.affiliation: Department of Ophthalmology, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China. neurogz@gmail.com.
authors.forename: Shi-hui
authors.initials: SH
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China. 583679961@qq.com.
authors.forename: Jie-feng
authors.initials: JF
authors.lastname: Geng
authors.affiliation: Department of Neurosurgery, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China. 769605008@qq.com.
authors.forename: Dong-dong
authors.initials: DD
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China. neurogz@gmail.com.
authors.forename: Xin-guang
authors.initials: XG
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China. cxl73@msn.com.
authors.forename: Xiao-lei
authors.initials: XL
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D016022:Case-Control Studies; D002648:Child; D004827:Epilepsy / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D060787:Neoplasm Grading; D038361:Neuronavigation; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery*; D055815:Young Adult