title: [THE AGING OF MICROVASCULAR NETWORK FORMED IN CORTEX FOLLOWING INTRACEREBRAL TRANSPLANTATION OF MESENCHYMAL STEM CELLS].
abstract: Using a TV device to study microcirculation in brain we found that intracerebral transplantation of mesenchymal stem cells to 12-months old rats led to a significant increase (circa 1,5-fold times) of microvascular density in pia tissue and to increased constriction reactions of pia arterioles in response to noradrenalin application on a brain surface. Both microvascular density and pia arterioles reactivity was completely preserved in aging until 22-24 months.
authors.forename: I B
authors.initials: IB
authors.lastname: Sokolova
authors.forename: S V
authors.initials: SV
authors.lastname: Anisimov
authors.forename: M V
authors.initials: MV
authors.lastname: Puzanov
authors.forename: I V
authors.initials: IV
authors.lastname: Sergeev
authors.forename: D P
authors.initials: DP
authors.lastname: Dvoretskiĭ
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008833:Microcirculation / Q000502:physiology*; D055806:Microvessels / Q000166:cytology*; D018919:Neovascularization, Physiologic; D010841:Pia Mater / Q000098:blood supply; D051381:Rats; D011921:Rats, Inbred WKY