title: Primary signet ring cell carcinoma of the colon and rectum.
abstract: Colorectal primary signet ring cell carcinoma (SRCC) is a rare entity accounting for nearly 1% of all colorectal carcinomas. It is an independent prognostic factor associated with less favorable outcome. This aggressiveness is mainly due to the intrinsic biology of these tumors. Here is an overview of the literature related to clinicopathological features, molecular biology, and management of SRCC of the colon and the rectum.
authors.affiliation: Hassan II university Hospital, Sidi Mohamed ben Abdullah University, School of medicine, Medical oncology department, Fez, Morocco; Hassan II university hospital, Mohamed ben Abdullah University, School of medicine, Laboratory of cancer biology, Fez, Morocco. Electronic address: drsarifi@yahoo.fr.
authors.forename: Samia
authors.initials: S
authors.lastname: Arifi
authors.affiliation: Hassan II university Hospital, Sidi Mohamed ben Abdullah University, School of medicine, Medical oncology department, Fez, Morocco.
authors.forename: Omar
authors.initials: O
authors.lastname: Elmesbahi
authors.affiliation: Hassan II university hospital, Mohamed ben Abdullah University, School of medicine, Laboratory of cancer biology, Fez, Morocco; Hassan II university Hospital, Mohamed ben Abdullah University, School of medicine, Pathology department, Fez, Morocco; Laboratory of pathology Al Azhar, Fez, Morocco.
authors.forename: Afaf
authors.initials: A
authors.lastname: Amarti Riffi
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D011905:Genes, ras; D006801:Humans; D015994:Incidence; D019656:Loss of Heterozygosity; D053842:Microsatellite Instability; D055271:Mucin 5AC / Q000378:metabolism; D055262:Mucin-2 / Q000378:metabolism; D009154:Mutation; D009363:Neoplasm Proteins / Q000378:metabolism; D011379:Prognosis; D035583:Rare Diseases / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D048490:raf Kinases / Q000235:genetics
chemical_list: C524625:MUC2 protein, human; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D055262:Mucin-2; D009363:Neoplasm Proteins; D048490:raf Kinases
keywords: Colorectal cancer; Molecular biology; Pathology; Signet ring cell; Treatment