title: Fundamental role of C1q in autoimmunity and inflammation.
abstract: C1q, historically viewed as the initiating component of the classical complement pathway, also exhibits a variety of complement-independent activities in both innate and acquired immunity. Recent studies focusing on C1q's suppressive role in the immune system have provided new insight into how abnormal C1q expression and bioactivity may contribute to autoimmunity. In particular, molecular networks involving C1q interactions with cell surface receptors and other ligands are emerging as mechanisms involved in C1q's modulation of immunity. Here, we discuss the role of C1q in controlling immune cell function, including recently elucidated mechanisms of action, and suggest how these processes are critical for maintaining tissue homeostasis under steady-state conditions and in preventing autoimmunity.
authors.affiliation: Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
authors.forename: Myoungsun
authors.initials: M
authors.lastname: Son
authors.affiliation: Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA. bdiamond@nshs.edu.
authors.forename: Betty
authors.initials: B
authors.lastname: Diamond
authors.affiliation: Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
authors.forename: Frances
authors.initials: F
authors.lastname: Santiago-Schwarz
mesh_terms: D000818:Animals; D015551:Autoimmunity; D015922:Complement C1q / Q000276:immunology / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007165:Immunosuppression Therapy; D007249:Inflammation / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D015922:Complement C1q
keywords: Autoimmunity; C1q; Complement; Inflammation; SLE