title: Disrupted inter-hemispheric functional and structural coupling in Internet addiction adolescents.
abstract: Rapid progress had been made towards the effect of Internet addiction (IA) on the adolescents brain, relatively little is known about the alterations in inter-hemispheric resting state functional connectivity (RSFC) changes. In the current study, voxel-mirrored homotopic connectivity (VMHC) was used to examine inter-hemispheric RSFC in IA adolescents (n=21) and controls (n=21). The integrity of the fibers connecting the regions, which showed aberrant inter-hemispheric functional connectivity, was assessed by fiber tractography analysis. In addition, the coupling of inter-hemispheric functional and structural connectivity was investigated. Relative to controls, IA adolescents showed decreased VMHC of dorsolateral prefrontal cortex (DLPFC) and reduced fractional anisotropy (FA) values in the genu of corpus callosum (CC). The decreased VMHC of DLPFC was significantly negative correlated with the duration of IA. Moreover, the VMHC of DLPFC showed significant correlations with the FA of CC in healthy controls, which was disrupted in IA. Our findings provided more scientific evidence for the involvement of DLPFC in IA. It is hoped that multimodal imaging methods can provide deeper insights into the IA effects on the brain.
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China.
authors.forename: Yanzhi
authors.initials: Y
authors.lastname: Bi
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China. Electronic address: kyuan@xidian.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Yuan
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Feng
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Xing
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China.
authors.forename: Yangding
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Medical Imaging, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, PR China.
authors.forename: Dahua
authors.initials: D
authors.lastname: Yu
authors.affiliation: School of Mathematics, Physics and Biological Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xue
authors.affiliation: Department of Medical Imaging, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address: jcw76@163.com.
authors.forename: Chenwang
authors.initials: C
authors.lastname: Jin
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China; Institute of Automation, Chinese Academy of Sciences, Beijing, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology; D016880:Anisotropy; D016739:Behavior, Addictive / Q000175:diagnosis* / Q000378:metabolism* / Q000523:psychology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D003337:Corpus Callosum / Q000378:metabolism / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D020407:Internet; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D055815:Young Adult
keywords: Corpus callosum; Dorsolateral prefrontal cortex; Fractional anisotropy; Internet addiction; Voxel-mirrored homotopic connectivity