title: Gallium-68 PSMA uptake in adrenal adenoma.
abstract: Gallium-68 (Ga-68) labelled prostate-specific membrane antigen (PSMA) imaging by positron emission tomography (PET) has emerged as a promising tool for staging of prostate cancer and restaging of disease in recurrence or biochemical failure after definitive treatment of prostate cancer. Ga-68 PSMA PET produces high target-to-background images of prostate cancer and its metastases which are reflective of the significant overexpression of PSMA in these cells and greatly facilitates tumour detection. However, relatively little is known about the PSMA expression of benign neoplasms and non-prostate epithelial malignancies. This is a case report of PSMA uptake in an adrenal adenoma incidentally discovered on PET performed for restaging of biochemically suspected prostate cancer recurrence. With the increasing use of PSMA PET in the management of prostate cancer - and the not infrequent occurrence of adrenal adenomas - the appearance of low- to moderate-grade PSMA uptake in adrenal adenomas should be one with which reporting clinicians are familiar.
authors.affiliation: Medical Imaging Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia.|School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: W Phillip
authors.initials: WP
authors.lastname: Law
authors.affiliation: Nuclear Medicine and Queensland PET Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors.forename: Frank
authors.initials: F
authors.lastname: Fiumara
authors.affiliation: Nuclear Medicine and Queensland PET Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors.forename: William
authors.initials: W
authors.lastname: Fong
authors.affiliation: Medical Imaging Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia.|Institute of Nuclear Medicine, University College London, London, UK.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Miles
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging*; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D000311:Adrenal Glands / Q000000981:diagnostic imaging; D000368:Aged; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics*; D006801:Humans; D033162:Incidental Findings; D008297:Male; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D017430:Prostate-Specific Antigen / Q000493:pharmacokinetics*; D011471:Prostatic Neoplasms / Q000473:pathology*
chemical_list: D005710:Gallium Radioisotopes; D017430:Prostate-Specific Antigen
keywords: PET; PSMA; adenoma; adrenal