title: Impact of Fighting on Antibody Response to Hepatitis B Virus Vaccine in Mice.
abstract: Antibody responses to vaccines can be influenced by various behavioral and psychosocial factors. Few reports exist on the impact of fighting on antibody response to vaccines. This study unexpectedly found that fighting could significantly enhance antibody production in male mice immunized with hepatitis B virus (HBV) vaccines. To confirm the finding, a mouse-fighting model was established in which it was observed that only intense fighting, not mild fighting, enhanced the antibody response to HBV surface antigen in male mice, and that the frequency of fighting and active attacks during fighting showed no obvious relationship with the antibody levels in the male mice that experienced fighting. In addition, fighting can cause significant upregulation of CD80 in CD11c(+) cells in the spleen of male mice. These data suggest that fighting could influence the humoral immune response in individuals immunized with vaccines or infected with microbes.
authors.affiliation: 1 Department of Molecular Biology, Jilin University , Changchun, China .
authors.forename: Sheng
authors.initials: S
authors.lastname: Guo
authors.affiliation: 1 Department of Molecular Biology, Jilin University , Changchun, China .
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: 1 Department of Molecular Biology, Jilin University , Changchun, China .
authors.forename: Min
authors.initials: M
authors.lastname: Wan
authors.affiliation: 2 Department of Immunology, College of Basic Medical Sciences, Norman Bethune Health Science Center, Jilin University , Changchun, China .
authors.forename: Li
authors.initials: L
authors.lastname: Hua
authors.affiliation: 1 Department of Molecular Biology, Jilin University , Changchun, China .
authors.forename: Yue
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: 2 Department of Immunology, College of Basic Medical Sciences, Norman Bethune Health Science Center, Jilin University , Changchun, China .
authors.forename: Boqi
authors.initials: B
authors.lastname: Dong
authors.affiliation: 1 Department of Molecular Biology, Jilin University , Changchun, China .
authors.forename: Jialin
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1 Department of Molecular Biology, Jilin University , Changchun, China .
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Diao
authors.affiliation: 2 Department of Immunology, College of Basic Medical Sciences, Norman Bethune Health Science Center, Jilin University , Changchun, China .
authors.forename: Yongli
authors.initials: Y
authors.lastname: Yu
authors.affiliation: 1 Department of Molecular Biology, Jilin University , Changchun, China .
authors.forename: Liying
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D000917:Antibody Formation; D018122:B7-1 Antigen / Q000032:analysis; D001522:Behavior, Animal; D039521:CD11c Antigen / Q000032:analysis; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D016130:Immunophenotyping; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011584:Psychology; D013154:Spleen / Q000276:immunology
chemical_list: D018122:B7-1 Antigen; D039521:CD11c Antigen; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines