title: A positive-negative mode of population covariation links brain connectivity, demographics and behavior.
abstract: We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.
authors.affiliation: Oxford University Centre for Functional MRI of the Brain (FMRIB), Oxford, UK.
authors.forename: Stephen M
authors.identifier: http://orcid.org/0000-0001-8166-069X
authors.initials: SM
authors.lastname: Smith
authors.affiliation: Department of Statistics and Warwick Manufacturing Group, University of Warwick, Coventry, UK.
authors.forename: Thomas E
authors.identifier: http://orcid.org/0000-0002-4516-5103
authors.initials: TE
authors.lastname: Nichols
authors.affiliation: Oxford University Centre for Human Brain Activity (OHBA), Oxford, UK.
authors.forename: Diego
authors.initials: D
authors.lastname: Vidaurre
authors.affiliation: Oxford University Centre for Functional MRI of the Brain (FMRIB), Oxford, UK.
authors.forename: Anderson M
authors.identifier: http://orcid.org/0000-0002-4169-9781
authors.initials: AM
authors.lastname: Winkler
authors.affiliation: Oxford University Centre for Functional MRI of the Brain (FMRIB), Oxford, UK.
authors.forename: Timothy E J
authors.initials: TE
authors.lastname: Behrens
authors.affiliation: Washington University School of Medicine, Washington University, St. Louis, Missouri, USA.
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Glasser
authors.affiliation: Center for Magnetic Resonance Research, University of Minnesota, Minnesota, USA.
authors.forename: Kamil
authors.initials: K
authors.lastname: Ugurbil
authors.affiliation: Washington University School of Medicine, Washington University, St. Louis, Missouri, USA.
authors.forename: Deanna M
authors.initials: DM
authors.lastname: Barch
authors.affiliation: Washington University School of Medicine, Washington University, St. Louis, Missouri, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Van Essen
authors.affiliation: Oxford University Centre for Functional MRI of the Brain (FMRIB), Oxford, UK.
authors.forename: Karla L
authors.initials: KL
authors.lastname: Miller
mesh_terms: D000328:Adult; D001519:Behavior / Q000502:physiology*; D001921:Brain / Q000166:cytology* / Q000502:physiology; D016000:Cluster Analysis; D063132:Connectome / Q000379:methods; D003710:Demography / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000166:cytology* / Q000502:physiology; D055815:Young Adult