title: Dormancy models for Mycobacterium tuberculosis: A minireview.
abstract: Dormancy models for Mycobacterium tuberculosis play important roles in understanding various aspects of tuberculosis pathogenesis and in the testing of novel therapeutic regimens. By simulating the latent tuberculosis infection, in which the bacteria exist in a non-replicative state, the models demonstrate reduced susceptibility to antimycobacterial agents. This minireview outlines the models available for simulating latent tuberculosis both in vitro and in several animal species. Additionally, this minireview discusses the advantages and disadvantages of these models for investigating the bacterial subpopulations and susceptibilities to sterilization by various antituberculosis drugs.
authors.affiliation: King Fahad Hospital of the University, College of Medicine, University of Dammam, Dammam, Saudi Arabia .
authors.forename: Amani M
authors.initials: AM
authors.lastname: Alnimr
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D024881:Drug Resistance, Bacterial; D006168:Guinea Pigs; D007202:Indicators and Reagents / Q000494:pharmacology; D055985:Latent Tuberculosis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D008252:Macaca fascicularis; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D010078:Oxazines / Q000494:pharmacology; D011817:Rabbits; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D014966:Xanthenes / Q000494:pharmacology; D015027:Zebrafish
chemical_list: D000995:Antitubercular Agents; D007202:Indicators and Reagents; D010078:Oxazines; D014966:Xanthenes; C005843:resazurin
keywords: dormancy; latency; stationary-phase; tuberculosis