title: [Composite lymphoma: Simultaneous development of three different lymphomas in a single patient: A clinical case].
abstract: In the past decades, there has been an increase in the incidence of malignancies, including polyneoplasms. Composite synchronous lymphoma characterized by the simultaneous development of several lymphoproliferative diseases occurs very rarely. This paper describes a case of development of 3 different lymphomas in the same patient. Aggressive T-cell lymphoma and indolent B-cell lymphoma are diagnosed during lifetime; primary central nervous system lymphoma is verified only by examination of autopsy material. Three different lymphomas could be identified by an integrated assessment of their clinical picture and by current diagnostic techniques, such as histology, immunohistochemistry, and molecular genetics.
authors.affiliation: Hematology Research Center, Ministry of Health of Russia, Moscow, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Chernova
authors.affiliation: Hematology Research Center, Ministry of Health of Russia, Moscow, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Sidorova
authors.affiliation: Hematology Research Center, Ministry of Health of Russia, Moscow, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Sinitsina
authors.affiliation: Hematology Research Center, Ministry of Health of Russia, Moscow, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Sudarikov
authors.affiliation: Hematology Research Center, Ministry of Health of Russia, Moscow, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Kovrigina
authors.affiliation: Hematology Research Center, Ministry of Health of Russia, Moscow, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Zvonkov
mesh_terms: D001344:Autopsy; D016543:Central Nervous System Neoplasms / Q000175:diagnosis*; D058617:Composite Lymphoma / Q000175:diagnosis*; D017809:Fatal Outcome; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D016399:Lymphoma, T-Cell / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged