title: A Stimuli-Responsive Rotaxane-Gold Catalyst: Regulation of Activity and Diastereoselectivity.
abstract: A rotaxane-based Au catalyst was developed and the effect of the mechanical bond on its behavior was studied. Unlike the non-interlocked thread, the rotaxane requires a catalytically innocent cofactor, the identity of which significantly influences both the yield and diastereoselectivity of the reaction. Under optimized conditions, Au(I) (the catalyst), Ag(I) (to abstract the Cl(-) ligand), and Cu(I) (the cofactor) combine to produce a catalyst with excellent activity and selectivity.
authors.affiliation: School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ (UK).
authors.forename: Marzia
authors.initials: M
authors.lastname: Galli
authors.affiliation: School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ (UK).
authors.forename: James E M
authors.initials: JE
authors.lastname: Lewis
authors.affiliation: School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ (UK). s.goldup@soton.ac.uk.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Goldup
keywords: catalysts; gold; molecular machines; rotaxanes; supramolecular chemistry