title: Acute Myeloid Leukemia Genetics: Risk Stratification and Implications for Therapy.
abstract: Acute myeloid leukemia is a category of diseases with a common aggressive clinical presentation but with a prognosis and management that is dependent upon the underlying genetic characteristics of the neoplasm. The purpose of this brief review is to update the practicing pathologist on the current standard of care in the genetic evaluation of acute myeloid leukemia and to highlight future directions in the classification, genetic assessment, and management of these devastating diseases.
authors.affiliation: From the Department of Pathology, University of Michigan, Ann Arbor.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Wang
authors.forename: Nathanael G
authors.initials: NG
authors.lastname: Bailey
mesh_terms: D000208:Acute Disease; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D002872:Chromosome Deletion; D006801:Humans; D007951:Leukemia, Myeloid / Q000145:classification / Q000235:genetics* / Q000628:therapy; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics; D000090243:Nucleophosmin; D012307:Risk Factors; D014178:Translocation, Genetic; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; D009687:Nuclear Proteins; D000090243:Nucleophosmin; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3