title: Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones.
abstract: A highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to 5-alkylidene thia(oxa)zolidine-2,4-diones catalyzed by a chiral N,O-ligand/Cu(CH3CN)4BF4 system is reported, affording structurally novel spirocyclic pyrrolidine-thia(oxa)zolidinediones with a spiro-heteroquaternary stereogenic center in good to excellent yields (up to 99%), with excellent levels of diastereo- and enantioselectivity (dr up to 99:1; ee up to 98%).
authors.affiliation: School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, P. R. China.
authors.forename: Wu-Lin
authors.initials: WL
authors.lastname: Yang
authors.affiliation: School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, P. R. China.
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Tang
authors.affiliation: School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, P. R. China.
authors.forename: Fu-Sheng
authors.initials: FS
authors.lastname: He
authors.affiliation: School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, P. R. China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Li
authors.affiliation: School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, P. R. China.
authors.forename: Xingxin
authors.initials: X
authors.lastname: Yu
authors.affiliation: School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, P. R. China.
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Deng