title: Predictive Value of School-Aged Children's Schistosomiasis Prevalence and Egg Intensity for Other Age Groups in Western Kenya.
abstract: World Health Organization recommendations for the timing and target population for mass drug administration (MDA) for schistosomiasis are based on the prevalence of infection in school children within a given community. In a large study comparing MDA approaches for Schistosoma mansoni control, we evaluated whether prevalence of infection and egg burdens in 9- to 12-year-old students reflected infection levels in young children and adults in the same community. Cross-sectional surveys of preadolescents (9-12 years old) were compared with those of first year students (5-8 years old) in 225 villages and adults (20-55 years old) in 150 villages along the Kenyan shores of Lake Victoria. Village schistosomiasis prevalence and intensity levels in preadolescents strongly correlated (P < 0.0001) with prevalence and infection intensity for other age groups in the community. Our findings suggest that S. mansoni prevalence and intensity among 9- to 12-year-olds are valid for community sampling purposes in mapping for MDAs.
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Pauline N M
authors.initials: PN
authors.lastname: Mwinzi
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Muchiri
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Ryan E
authors.initials: RE
authors.lastname: Wiegand
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Martin
authors.initials: M
authors.lastname: Omedo
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Bernard
authors.initials: B
authors.lastname: Abudho
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Diana M S
authors.initials: DM
authors.lastname: Karanja
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Susan P
authors.initials: SP
authors.lastname: Montgomery
authors.affiliation: Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia was4@cdc.gov.
authors.forename: W Evan
authors.initials: WE
authors.lastname: Secor
mesh_terms: D000328:Adult; D000367:Age Factors; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000469:parasitology; D006306:Health Surveys / Q000379:methods; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008875:Middle Aged; D010270:Parasite Egg Count / Q000379:methods* / Q000706:statistics & numerical data; D015995:Prevalence; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D012720:Severity of Illness Index; D055815:Young Adult