title: Selenium-Platinum Coordination Dendrimers with Controlled Anti-Cancer Activity.
abstract: Dendrimers are considered as good vectors for drug delivery in cancer treatment. However, most anticancer drugs are conjugated to the peripheral surface of dendrimers, sacrificing the advantages of monodispersity and stability belonging to dendrimers. Furthermore, dendrimers in current studies of cancer treatment are mostly used as vectors for drugs, whereas the anticancer activity of dendrimers on their own is less studied. Here we have prepared monodisperse selenium-platinum coordination dendrimers with a selenium-platinum core buried inside. Structures of the dendrimers were determined by various characterizations. The coordination dendrimers showed controlled anticancer activity by themselves, without loading additional drugs. The in vivo study further demonstrated their anticancer activity and low toxicity to normal tissues.
authors.affiliation: Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University , Beijing 100084, People's Republic of China.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of Leuven , Celestijnenlaan 200F, B-3001 Heverlee (Leuven), Belgium.
authors.forename: Mario
authors.initials: M
authors.lastname: Smet
authors.affiliation: Department of Chemistry, University of Leuven , Celestijnenlaan 200F, B-3001 Heverlee (Leuven), Belgium.
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen
authors.affiliation: Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University , Beijing 100084, People's Republic of China.
authors.forename: Huaping
authors.initials: H
authors.lastname: Xu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017671:Platinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018036:Selenium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D017671:Platinum Compounds; D018036:Selenium Compounds
keywords: anticancer; coordination; dendrimer; platinum; selenium