title: Morphological features in eyes with endophthalmitis after cataract surgery - histopathology and optical coherence tomography assessment.
abstract: OBJECTIVE
  To assess the ocular damage that occurs in eyes with postoperative endophthalmitis after cataract surgery (PE) based on optical coherence tomography (OCT) retinal scans of PE eyes and histological specimens of eyes removed due to PE.
  
  
  METHODS
  Case-control study and case series. Fifty-one patients who had previously developed PE were clinically examined with OCT scans of the retina of both eyes. Histological specimens of 10 removed PE eyes were studied.
  
  
  RESULTS
  The OCT scans showed that PE eyes had a statistically significantly higher frequency of hyperdense elements on the internal limiting membrane (ILM) of the retina (14 eyes versus 3 eyes, p = 0.015) and a higher degree of retinal atrophy temporal to the fovea (13 eyes versus 1 eye, p = 0.013) compared to fellow eyes. The histopathological analyses showed the formation of epiretinal membranes, derangement of all retinal layers with a reduced number of nuclei in the nuclear layers, loss of photoreceptor outer segments and massive retinal gliosis.
  
  
  CONCLUSIONS
  Optical coherence tomography scans of the retina and histopathology analyses provide insights in the pathological process occurring in PE.
authors.affiliation: Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Solborg Bjerrum
authors.affiliation: Eye Pathology Institute, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jan Ulrik
authors.initials: JU
authors.lastname: Prause
authors.affiliation: Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Josefine
authors.initials: J
authors.lastname: Fuchs
authors.affiliation: Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: la Cour
authors.affiliation: Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Jens F
authors.identifier: http://orcid.org/0000-0003-1054-1460
authors.initials: JF
authors.lastname: Kiilgaard
mesh_terms: D001284:Atrophy; D001485:Basement Membrane / Q000473:pathology; D016022:Case-Control Studies; D009877:Endophthalmitis / Q000382:microbiology / Q000473:pathology*; D019773:Epiretinal Membrane / Q000382:microbiology / Q000473:pathology*; D015818:Eye Infections, Bacterial / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D008268:Macular Degeneration / Q000382:microbiology / Q000473:pathology*; D008297:Male; D018918:Phacoemulsification; D011183:Postoperative Complications; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence
keywords: cataract surgery; endophthalmitis; inflammation; optical coherence tomography