title: Impact of Glycopeptide Resistance in Staphylococcus aureus on the Dalbavancin In Vivo Pharmacodynamic Target.
abstract: Dalbavancin is a novel lipoglycopeptide with activity against Staphylococcus aureus, including glycopeptide-resistant isolates. The in vivo investigation reported here tested the effects of this antibiotic against seven S. aureus isolates with higher MICs, including several vancomycin-intermediate strains. Results of 1-log kill and 2-log kill were achieved against seven and six of the isolates, respectively. The mean free-drug area under the concentration-time curve (fAUC)/MIC values for net stasis, 1-log kill, and 2-log kill were 27.1, 53.3, and 111.1, respectively.
authors.affiliation: Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lepak
authors.affiliation: Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
authors.forename: K
authors.initials: K
authors.lastname: Marchillo
authors.affiliation: Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
authors.forename: J
authors.initials: J
authors.lastname: VanHecker
authors.affiliation: Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA dra@medicine.wisc.edu.
authors.forename: D
authors.initials: D
authors.lastname: Andes
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D019540:Area Under Curve; D017576:Daptomycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D007274:Injections, Intraperitoneal; D051379:Mice; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D017334:Teicoplanin / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D014640:Vancomycin; C469289:dalbavancin; D017576:Daptomycin