title: Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: a pilot study.
abstract: BACKGROUND
  The effects on the inflammatory and tanning responses of sunlight/UVR of several oral antioxidants are still unknown.
  
  
  OBJECTIVE
  Assess intensity, time course of the inflammatory, and tanning responses to increasing dosages of solar-simulated radiation (SSR) at baseline and after oral supplementation of an extract of Polypodium leucotomos (PLE).
  
  
  METHODS
  Ten healthy subjects underwent phototesting with SSR with a visual and spectrophotometrical assessment of the responses with or without daily oral supplementation of two tablets containing 240 mg of PLE for a total of 15 days.
  
  
  RESULTS
  Polypodium leucotomos supplementation induced a significant increase of the minimal erythema dose (MED), a faster recovery of the inflammation following the delivery of super-erythemal doses, and no significant changes of the minimal melanogenic dose (MMD). Spectrophotometric assessment of the Δa* in test areas exposed to equally doses of SSR did not show differences.
  
  
  CONCLUSIONS
  Polypodium leucotomos supplementation increased the MED and induced a faster recovery of the inflammation and a stronger tanning response with no changes in the melanogenic threshold.
authors.affiliation: Department of Dermatology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
authors.forename: Pier Giacomo
authors.initials: PG
authors.lastname: Calzavara-Pinton
authors.affiliation: Department of Dermatology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Rossi
authors.affiliation: Department of Dermatology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: Zanca
authors.affiliation: Department of Dermatology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
authors.forename: Mariachiara
authors.initials: M
authors.lastname: Arisi
authors.affiliation: Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Salvador
authors.initials: S
authors.lastname: Gonzalez
authors.affiliation: Department of Dermatology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Venturini
keywords: Polypodium leucotomos; inflammation; solar-simulated radiation; spectrophotometry; tanning