title: Microbiome and pediatric atopic dermatitis.
abstract: Atopic dermatitis is a chronic inflammatory skin condition with drastic impacts on pediatric health. The pathogenesis of this common disease is not well understood, and the complex role of the skin microbiome in the pathogenesis and progression of atopic dermatitis is being elucidated. Skin commensal organisms promote normal immune system functions and prevent the colonization of pathogens. Alterations in the skin microbiome may lead to increased Staphylococcus aureus colonization and atopic dermatitis progression. Despite the evidence for their important role, probiotics have not been deemed efficacious for the treatment of atopic dermatitis, although studies suggest that probiotics may be effective at preventing the development of atopic dermatitis when given to young infants. This review will cover the most recent published work on the microbiome and pediatric atopic dermatitis.
authors.affiliation: Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Claire E
authors.initials: CE
authors.lastname: Powers
authors.affiliation: Department of Dermatology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Diana B
authors.initials: DB
authors.lastname: McShane
authors.affiliation: Clinical Microbiology-Immunology Laboratories, University of North Carolina Hospitals, Chapel Hill, North Carolina, USA.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Gilligan
authors.affiliation: Department of Dermatology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Craig N
authors.initials: CN
authors.lastname: Burkhart
authors.affiliation: Department of Dermatology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Dean S
authors.initials: DS
authors.lastname: Morrell
mesh_terms: D002648:Child; D003876:Dermatitis, Atopic / Q000209:etiology / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D064307:Microbiota; D019936:Probiotics / Q000627:therapeutic use; D012867:Skin / Q000382:microbiology; D013207:Staphylococcal Skin Infections / Q000150:complications / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity
keywords: Staphylococcus aureus; antimicrobial cationic peptides; atopic dermatitis; microbiota; probiotics