title: Improving the (18)F-fluoromethylcholine ((18)F-FCH) radiochemical yield via optimising the azeotropic drying of non-carrier-added (18)F-fluorine.
abstract: (18)F-Fluoromethylcholine ((18)F-FCH) has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in PET/CT examination. Nevertheless, it has never been synthesised in Malaysia. We acknowledged the major problem with (18)F-FCH is due to its relatively low radiochemical yield at the end of synthesis (EOS). Therefore, this technical note presents improved (18)F-FCH radiochemical yields after carrying out optimisation on azeotropic drying of non-carrier-added (18)F-Fluorine.
authors.affiliation: Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Serdang, Malaysia.
authors.forename: Hishar
authors.initials: H
authors.lastname: Hassan
authors.affiliation: National Cancer Institute, Putrajaya, Malaysia.
authors.forename: Suharzelim
authors.initials: S
authors.lastname: Abu Bakar
authors.affiliation: National Cancer Institute, Putrajaya, Malaysia.
authors.forename: Khairul Najah Che A
authors.initials: KN
authors.lastname: Halim
authors.affiliation: National Cancer Institute, Putrajaya, Malaysia.
authors.forename: Jaleezah
authors.initials: J
authors.lastname: Idris
authors.affiliation: Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Serdang, Malaysia.
authors.forename: Fathinul Fikri
authors.initials: FF
authors.lastname: Ahmad Saad
authors.affiliation: Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Serdang, Malaysia.
authors.forename: Abdul Jalil
authors.initials: AJ
authors.lastname: Nordin
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000295:instrumentation / Q000379:methods*; D002794:Choline / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D003890:Desiccation / Q000295:instrumentation / Q000379:methods*; D005462:Fluorine Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; C514960:fluorocholine; D002794:Choline
keywords: F-18 Fluorocholine; azeotropic drying; quality control analysis; radiochemical yield