title: What effect can manual therapy have on a patient's pain experience?
abstract: Manual therapy (MT) is a passive, skilled movement applied by clinicians that directly or indirectly targets a variety of anatomical structures or systems, which is utilized with the intent to create beneficial changes in some aspect of the patient pain experience. Collectively, the process of MT is grounded on clinical reasoning to enhance patient management for musculoskeletal pain by influencing factors from a multidimensional perspective that have potential to positively impact clinical outcomes. The influence of biomechanical, neurophysiological, psychological and nonspecific patient factors as treatment mediators and/or moderators provides additional information related to the process and potential mechanisms by which MT may be effective. As healthcare delivery advances toward personalized approaches there is a crucial need to advance our understanding of the underlying mechanisms associated with MT effectiveness.
authors.affiliation: Department of Physical Therapy, PO Box 100154, University of Florida, Gainesville, FL 32610, USA.|Center for Pain Research & Behavioral Health, PO Box 100165, University of Florida, Gainesville, FL 32610, USA.|Pain Research & Investigation Center of Excellence, 2004 Mowry Road, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Bishop
authors.affiliation: Department of Physical Therapy, University of Valencia, Av. de Blasco Ibáñez, 13, 46010 València, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Torres-Cueco
authors.affiliation: Department of Physical Therapy, PO Box 100154, University of Florida, Gainesville, FL 32610, USA.|Center for Pain Research & Behavioral Health, PO Box 100165, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Gay
authors.affiliation: Department of Physical Therapy, University of Valencia, Av. de Blasco Ibáñez, 13, 46010 València, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Lluch-Girbés
authors.affiliation: Department of Physical Therapy, PO Box 100154, University of Florida, Gainesville, FL 32610, USA.|Brooks Rehabilitation-College of Public Health & Health Professions Research Collaboration, PO Box 100154, University of Florida, Gainesville, FL, 32610, USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Beneciuk
authors.affiliation: Department of Physical Therapy, PO Box 100154, University of Florida, Gainesville, FL 32610, USA.|Center for Pain Research & Behavioral Health, PO Box 100165, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Joel E
authors.initials: JE
authors.lastname: Bialosky
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D018836:Inflammation Mediators; D008297:Male; D059352:Musculoskeletal Pain / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology*; D059408:Pain Management; D058748:Pain Perception / Q000502:physiology; D026741:Physical Therapy Modalities; D013116:Spinal Cord / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D018836:Inflammation Mediators
keywords: biomechanical; clinical reasoning; effectiveness; expectation; neurophysiological; placebo; preference; psychological; treatment mediation; treatment moderation