title: A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin-Maqui Berry Extract (Delphinol®) on Oxidative Stress Biomarkers.
abstract: OBJECTIVE
  Berries are a rich source of anthocyanins, and clinical data suggest that a polyphenol-rich diet may exert health-promoting effects by reducing oxidative stress. The aim of this study was to elucidate the effects of dietary supplementation with Delphinol (trademark owned by MNL Chile) standardized maqui berry (Aristotelia chilensis) extract on products of lipid peroxidation in healthy, overweight, and smoker subjects.
  
  
  METHODS
  In a double-blind, placebo-controlled design, 42 participants (age 45-65 years) consumed in random order either a standardized extract of maqui berry (162 mg anthocyanins) or a matched placebo, given 3 times daily for 4 weeks. The samples were collected at baseline, after the end of the supplementation, and 40 days after the end of the study. Primary outcome was the measure of oxidized low-density lipoprotein (Ox-LDL) and F2-isoprostanes in plasma and urine, respectively. Secondary outcomes included anthropometric measures, blood pressure, and lipid profile.
  
  
  RESULTS
  Delphinol supplementation was associated with reduced levels of Ox-LDL in the anthocyanin group compared to baseline (p < 0.05). There was also a decrease in urinary F2-isoprostanes (8-iso-prostaglandin F2α) at 4 weeks versus baseline in the Delphinol-supplemented group (p < 0.05). However, no differences in primary outcomes were evident at 40 days of follow-up. In the fourth week of the intervention, no significant differences were noted for anthropometric characteristics, ambulatory blood pressure, and lipid profile.
  
  
  CONCLUSIONS
  Our observations suggest that dietary interventions with maqui berry extract may improve oxidative status (Ox-LDL and F2-isoprostanes) in healthy adults, overweight adults, and adult smokers.
authors.affiliation: a Department of Medicine and Health Sciences , University of Molise , Campobasso , ITALY.
authors.forename: Sergio
authors.initials: S
authors.lastname: Davinelli
authors.affiliation: b Department of Medicine , Hospital Clinico Regional de Valdivia , Valdivia , CHILE.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Bertoglio
authors.affiliation: c Department of Chemical Sciences , University of Napoli 'Federico II , Napoli , ITALY.
authors.forename: Armando
authors.initials: A
authors.lastname: Zarrelli
authors.affiliation: d Equipe Enervit Srl , Scientific Unit of Enervit Spa , Milano , ITALY.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pina
authors.affiliation: a Department of Medicine and Health Sciences , University of Molise , Campobasso , ITALY.|e Inter-University Consortium "SannioTech" , Apollosa ( BN ), ITALY.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scapagnini
mesh_terms: D000368:Aged; D000872:Anthocyanins / Q000494:pharmacology*; D000886:Anthropometry; D000975:Antioxidants / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D019587:Dietary Supplements; D004311:Double-Blind Method; D028441:F2-Isoprostanes / Q000652:urine; D005260:Female; D005638:Fruit / Q000737:chemistry*; D064368:Healthy Volunteers; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood / Q000178:diet therapy* / Q000652:urine; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D012907:Smoking
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D015415:Biomarkers; D028441:F2-Isoprostanes; D008055:Lipids; D008077:Lipoproteins, LDL; D010936:Plant Extracts; C099252:oxidized low density lipoprotein; C017185:delphinidin
keywords: F2-isoprostanes; anthocyanin; berry; oxidative stress; oxidized LDL