title: RETRACTED: MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line.
abstract: MiR-122 is a novel tumor suppresser and its expression induces cell cycle arrest, or apoptosis, and inhibits cell proliferation in multiple cancer cells, including non-small cell lung cancer (NSCLC) cells. Radioresistance of cancer cell leads to the major drawback of radiotherapy for NSCLC and the induction of radiosensitization could be a useful strategy to fix this problem. The present work investigates the function of miR-122 in inducing radiosensitization in A549 cell, a type of NSCLC cells. MiR-122 induces the radiosensitization of A549 cells. MiR-122 also boosts the inhibitory activity of ionizing radiation (IR) on cancer cell anchor-independent growth and invasion. Moreover, miR-122 reduced the expression of its targeted genes related to tumor-survival or cellular stress response. These results indicate that miR-122 would be a novel strategy for NSCLC radiation-therapy.
authors.affiliation: Department of Respiratory Diseases, General Hospital of Shenyang Military Command, Shenyang 110016, China. madebin119@163.com.
authors.forename: Debin
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China. smockingandy@163.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Jia
authors.affiliation: Department of Respiratory Diseases, General Hospital of Shenyang Military Command, Shenyang 110016, China. qinmengmeng@hotmail.com.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Qin
authors.affiliation: Department of Pharmacy, Beijing Chuiyangliu Hospital Affiliated to Tsinghua University, Beijing 100022, China. wenjiedai.2009@163.com.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Dai
authors.affiliation: Institute of Toxicology and Pharmacology, Medicine Military Medical Science Academy of the Chinese PLA, Beijing 100850, China. wangtaojk2007@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Institute of Toxicology and Pharmacology, Medicine Military Medical Science Academy of the Chinese PLA, Beijing 100850, China. lstyqw@163.com.
authors.forename: Erguang
authors.initials: E
authors.lastname: Liang
authors.affiliation: Institute of Radiation, Medicine Military Medical Science Academy of the Chinese PLA, Beijing 100850, China. dongguofu052@126.com.
authors.forename: Guofu
authors.initials: G
authors.lastname: Dong
authors.affiliation: Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China. zuojunwang2010@yahoo.com.
authors.forename: Zuojun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Respiratory Diseases, General Hospital of Shenyang Military Command, Shenyang 110016, China. yuan@live.cn.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China. fengfanbio@126.com.
authors.forename: Fan
authors.initials: F
authors.lastname: Feng
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000528:radiation effects; D049109:Cell Proliferation / Q000528:radiation effects; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011836:Radiation Tolerance; D011839:Radiation, Ionizing
chemical_list: C531907:MIRN122 microRNA, human; D035683:MicroRNAs
keywords: adenoviral vector; ionizing radiation; microrna122; non-small cell lung cancer; radiosensitization