title: Isocoumarins from the fermentation products of a plant entophytic fungus Penicillium oxalicum.
abstract: Three new isocoumarins, terrecoumarins A-C (1-3), together with six known isocoumarins (4-9) were isolated from the fermentation products of the fungus Penicillium oxalicum 0403. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1-9 were evaluated. The results revealed that compound 1 showed high anti-TMV activity with inhibition rate 25.4 ± 3.5%. Other compounds also showed weak activity with inhibition rate in the range of 11.3-18.9%.
authors.affiliation: a Life Science College, Yunnan Normal University , Kunming 650500 , China.|b China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.|d Yunnan Haoruo Institute of Biotechnology , Kunming 650204 , China.
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Li
authors.affiliation: b China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Li-Zhi
authors.initials: LZ
authors.lastname: Dang
authors.affiliation: b China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Yi-Peng
authors.initials: YP
authors.lastname: Zhang
authors.affiliation: b China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Ju-Xing
authors.initials: JX
authors.lastname: Jiang
authors.affiliation: b China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Cheng-Ming
authors.initials: CM
authors.lastname: Zhang
authors.affiliation: b China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Neng-Jun
authors.initials: NJ
authors.lastname: Xiang
authors.affiliation: c Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Ministry of Education , Kunming 650500 , China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Yang
authors.affiliation: c Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Ministry of Education , Kunming 650500 , China.
authors.forename: Gang
authors.initials: G
authors.lastname: Du
authors.affiliation: b China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Duan
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D014027:Tobacco Mosaic Virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D049934:Isocoumarins; C000603691:terrecoumarin A; C000603692:terrecoumarin B; C000603693:terrecoumarin C
keywords: fungus Penicillium oxalicum; anti-tobacco mosaic virus; isocoumarins