title: Treatment of intrabony defects with guided tissue regeneration in aggressive periodontitis: clinical outcomes at 6 and 12 months.
abstract: OBJECTIVE
  The aim of this study was to compare clinical outcomes between guided tissue regeneration (GTR) and access flap (AF) surgery in patients with aggressive periodontitis (AgP).
  
  
  METHODS
  Eighteen AgP patients with similar bilateral intrabony defects were treated in this split-mouth, single-blinded, randomised, controlled clinical trial. All patients presented with ≥3 mm intrabony defects and ≥5 mm periodontal pocket depths (PPD). In each patient, one defect was treated with a polyglycolide membrane according to the GTR principle, whereas the contralateral side was treated with AF. For both sides, a simplified papilla preservation flap was used. At baseline, 6 and 12 months post-surgery, the clinical attachment levels (CAL) and PPD were evaluated.
  
  
  RESULTS
  At 6 and 12 months, at the GTR sites, the mean [95 % CI] CAL gain was 1.7 mm [1.1, 2.3] and 1.6 mm [0.9, 2.1], respectively, while the mean [95 % CI] PPD reduction was 2.3 mm [1.9, 2.8] and 2.4 mm [1.9, 2.8], respectively. Similar CAL (1.6 mm [1.0, 2.2] and 2.1 mm [1.4, 2.7]) and PPD (2.0 mm [1.5, 2.4] and 2.5 mm [2.0, 3.0]) outcomes were observed at the control sites at 6 and 12 months, respectively. Notably, at the GTR-treated sites, 13 subjects presented with various degrees of membrane exposure.
  
  
  CONCLUSIONS
  Both therapies were effective in the treatment of intrabony defects in AgP patients, and no statistically significant differences between them could be demonstrated, possibly as a result of the differing degrees of membrane exposure at the GTR sites.
  
  
  CONCLUSIONS
  Both periodontal regeneration and conventional periodontal surgery are effective treatments for AgP patients.
authors.affiliation: Periodontology Unit, Department of Clinical Research, UCL Eastman Dental Institute, London, UK.|Faculty of Dentistry, Thammasat University, Pathum Thani, Thailand.
authors.forename: Thanasak
authors.initials: T
authors.lastname: Rakmanee
authors.affiliation: Periodontology Unit, Department of Clinical Research, UCL Eastman Dental Institute, London, UK.|School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
authors.forename: Gareth S
authors.initials: GS
authors.lastname: Griffiths
authors.affiliation: Periodontology Unit, Department of Clinical Research, UCL Eastman Dental Institute, London, UK.
authors.forename: Gita
authors.initials: G
authors.lastname: Auplish
authors.affiliation: Periodontology Unit, Department of Clinical Research, UCL Eastman Dental Institute, London, UK.
authors.forename: Ulpee
authors.initials: U
authors.lastname: Darbar
authors.affiliation: Biostatistics Unit, UCL Eastman Dental Institute, London, UK.
authors.forename: Aviva
authors.initials: A
authors.lastname: Petrie
authors.affiliation: Periodontology Unit, Department of Clinical Research, UCL Eastman Dental Institute, London, UK.
authors.forename: Irwin
authors.initials: I
authors.lastname: Olsen
authors.affiliation: Periodontology Unit, Department of Clinical Research, UCL Eastman Dental Institute, London, UK. n.donos@ucl.ac.uk.|Department of Periodontology, UCL-Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD, UK. n.donos@ucl.ac.uk.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Donos
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000601:surgery*; D016301:Alveolar Bone Loss / Q000601:surgery*; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D016037:Single-Blind Method; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: D008567:Membranes, Artificial
keywords: Access flap surgery (AF); Aggressive periodontitis; Guided tissue regeneration (GTR); Randomised controlled clinical trial (RCT); Simplified papillary preservation flap (SPPF)