title: [Allergy to iodinated drugs and to foods rich in iodine: Iodine is not the allergenic determinant].
abstract: "Iodine allergy" does not exist. The concept of "iodine allergy" should be abandoned since it may result in inappropriate measures such as drug, food or environmental eviction. Immediate or non-immediate allergic hypersensitivity to iodinated contrast media is not infrequent. The corresponding allergens have not been identified. Iodine is not involved. Immediate or non-immediate allergic hypersensitivity to povidone iodine is rare. The corresponding allergen is povidone in case of immediate hypersensitivity while nonoxynol might be involved during non-immediate hypersensitivity. Seafood allergens belong to a group of muscle proteins. Immediate drug hypersensitivity or food hypersensitivity is assessed by immediate-reading skin tests while non-immediate drug hypersensitivity is investigated by delayed-reading skin testing. Combined histamine and tryptase measurement is invaluable during the diagnostic approach of immediate hypersensitivity. Other biological tests are being evaluated. Allergic hypersensitivity to iodinated contrast agents does not contraindicate the use of other iodinated drugs.
authors.affiliation: Université Paris Descartes Sorbonne Paris Cité, Inserm UMR-S970, AP-HP, hôpital européen Georges-Pompidou, service d'anesthésie-réanimation chirurgicale, 20, rue Leblanc, 75015 Paris, France. Electronic address: pascale.dewachter@inserm.fr.
authors.forename: Pascale
authors.initials: P
authors.lastname: Dewachter
authors.affiliation: Hôpital de Brabois, consultation d'allergo-anesthésie, 54511 Vandœuvre-lès-Nancy, France; AP-HP, hôpital européen Georges-Pompidou, consultation d'allergo-radiologie, 75015 Paris, France.
authors.forename: Claudie
authors.initials: C
authors.lastname: Mouton-Faivre
mesh_terms: D000485:Allergens / Q000009:adverse effects* / Q000276:immunology / Q000302:isolation & purification; D000638:Amiodarone / Q000009:adverse effects; D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000009:adverse effects / Q000737:chemistry; D015415:Biomarkers; D003287:Contrast Media / Q000009:adverse effects* / Q000737:chemistry; D003877:Dermatitis, Contact / Q000209:etiology; D004044:Dietary Proteins / Q000009:adverse effects / Q000276:immunology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000209:etiology; D007455:Iodine / Q000032:analysis / Q000502:physiology; D017613:Iodine Compounds / Q000009:adverse effects*; D009124:Muscle Proteins / Q000009:adverse effects / Q000276:immunology; D011193:Potassium Iodide / Q000009:adverse effects; D011206:Povidone-Iodine / Q000009:adverse effects; D017747:Seafood / Q000009:adverse effects*; D012882:Skin Tests; D013974:Thyroxine / Q000009:adverse effects; D053802:Tryptases / Q000097:blood
chemical_list: D000485:Allergens; D000891:Anti-Infective Agents, Local; D015415:Biomarkers; D003287:Contrast Media; D004044:Dietary Proteins; D017613:Iodine Compounds; D009124:Muscle Proteins; D011193:Potassium Iodide; D011206:Povidone-Iodine; D007455:Iodine; D053802:Tryptases; D000638:Amiodarone; D013974:Thyroxine