title: Hierarchical Structure and Mechanical Improvement of an n-HA/GCO-PU Composite Scaffold for Bone Regeneration.
abstract: To improve the mechanical properties of bone tissue and achieve the desired bone tissue regeneration for orthopedic surgery, newly designed hydroxyapatite/polyurethane (HA/PU) porous scaffolds were developed via in situ polymerization. The results showed that the molecular modification of PU soft segments by glyceride of castor oil (GCO) can increase the scaffold compressive strength by 48% and the elastic modulus by 96%. When nano-HA (n-HA) particles were incorporated into the GCO-PU matrix, the compressive strength and elastic modulus further increased by 49 and 74%, from 2.91 to 4.34 MPa and from 95 to 165.36 MPa, respectively. The n-HA particles with fine dispersity not only improved the interface bonding with the GCO-PU matrix but also provided effective bioactivity for bonding with bone tissue. The hierarchical structure and mechanical quality of the n-HA/GCO-PU composite scaffold were determined to be appropriate for the growth of cells and the regeneration of bony tissues, demonstrating promising prospects for bone repair and regeneration.
authors.affiliation: Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University , Chengdu 610064, People's Republic of China.
authors.forename: Limei
authors.initials: L
authors.lastname: Li
authors.affiliation: Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University , Chengdu 610064, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zuo
authors.affiliation: Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University , Chengdu 610064, People's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zou
authors.affiliation: Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University , Chengdu 610064, People's Republic of China.
authors.forename: Boyuan
authors.initials: B
authors.lastname: Yang
authors.affiliation: Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University , Chengdu 610064, People's Republic of China.
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.affiliation: Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University , Chengdu 610064, People's Republic of China.
authors.forename: Jidong
authors.initials: J
authors.lastname: Li
authors.affiliation: Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University , Chengdu 610064, People's Republic of China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000502:physiology; D002368:Castor Oil / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry*; D055119:Elastic Modulus; D005989:Glycerides / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010012:Osteogenesis / Q000187:drug effects; D056951:Photoelectron Spectroscopy; D011140:Polyurethanes / Q000737:chemistry*; D016062:Porosity; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D054457:Tissue Scaffolds / Q000737:chemistry; D055114:X-Ray Microtomography
chemical_list: D018786:Bone Substitutes; D005989:Glycerides; D011140:Polyurethanes; D002368:Castor Oil; D017886:Durapatite
keywords: bone regeneration; hierarchical structure; mechanical quality; nanohydroxyapatite; polyurethane composite