title: Cognitive dysfunctions in occipital lobe epilepsy compared to temporal lobe epilepsy.
abstract: To compare cognitive profiles of occipital lobe epilepsy (OLE) and temporal lobe epilepsy (TLE) and to investigate whether impairment of visuospatial functions is a specific deficit of OLE.
  
  
  
  Eighteen patients with OLE, 18 patients with TLE, and 18 controls underwent a neuropsychological battery assessing memory, visuospatial functions, and frontal/executive functions.
  
  
  
  Multivariate analysis evidenced poorer performance of patients with TLE and patients with OLE relative to controls on tasks assessing verbal and non-verbal long-term memory, frontal functions, and visuospatial functions. Patients with OLE had poorer performance than patients with TLE on visuospatial tasks, whereas patients with TLE performed worse than patients with OLE on verbal long-term memory test. Discriminant analysis identified two canonical discriminant functions: The first explained 53.3% of the variance, and the second explained 46.7% of the variance. The first function included verbal and non-verbal memory tests distinguishing controls from both OLE and TLE, whereas the second factor including a visuoconstructional test distinguished OLE from TLE and controls.
  
  
  
  The results demonstrate that visuoconstructional dysfunction is related to OLE and support the idea that alterations of occipito-parietal stream may be specific to patients with OLE.
authors.affiliation: Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy.|Institute for Diagnosis and Care, 'Hermitage-Capodimonte', Naples, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Santangelo
authors.affiliation: Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy.|Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy.
authors.forename: Luigi
authors.identifier: 0000-0002-0328-9642
authors.initials: L
authors.lastname: Trojano
authors.affiliation: Institute for Diagnosis and Care, 'Hermitage-Capodimonte', Naples, Italy.|Deptartment of Motor Sciences and Wellbeing, University of Naples 'Parthenope', Naples, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Vitale
authors.affiliation: Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Improta
authors.affiliation: Department of Psychology, Columbia University, New York, New York, USA.
authors.forename: Irma
authors.initials: I
authors.lastname: Alineri
authors.affiliation: Neurology Outpatients Service, Naples Local Health Unit, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Meo
authors.affiliation: Epilepsy Center, Department of Neuroscience, Reproductive and Odontostomatologic Sciences, University of Naples Federico II, Italy.
authors.forename: Leonilda
authors.initials: L
authors.lastname: Bilo
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D004828:Epilepsies, Partial / Q000150:complications*; D004833:Epilepsy, Temporal Lobe / Q000150:complications*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
keywords: cognitive dysfunctions; cognitive functioning; epilepsy; executive functions; frontal functions; memory; occipital lobe epilepsy; temporal lobe epilepsy; visuospatial functions