title: Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide.
abstract: An iron(III)-catalyzed method for the rapid and highly regioselective iodination of arenes has been developed. Use of the powerful Lewis acid, iron(III) triflimide, generated in situ from iron(III) chloride and a readily available triflimide-based ionic liquid allowed activation of N-iodosuccinimide (NIS) and efficient iodination under mild conditions of a wide range of substrates including biologically active compounds and molecular imaging agents.
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow , Glasgow G12 8QQ, U.K.
authors.forename: Daugirdas T
authors.initials: DT
authors.lastname: Racys
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow , Glasgow G12 8QQ, U.K.
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Warrilow
authors.affiliation: West of Scotland Radionuclide Dispensary, University of Glasgow and North Glasgow University Hospital NHS Trust , Glasgow G11 6NT, U.K.
authors.forename: Sally L
authors.initials: SL
authors.lastname: Pimlott
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow , Glasgow G12 8QQ, U.K.
authors.forename: Andrew
authors.initials: A
authors.lastname: Sutherland