title: Potential drug-drug interactions in oncological adult inpatients at a Spanish hospital: epidemiology and risk factors.
abstract: BACKGROUND
  Oncological patients are at high risk for drug-drug interactions (DDIs), which may contribute to therapeutic failure or lead to serious adverse events.
  
  
  OBJECTIVE
  To determine the prevalence of potential DDIs in medication lists, to describe the most frequent DDIs and to investigate the possible risk factors associated with them. A prospective cohort study was performed at the Oncology Department of a tertiary hospital over a 12-week period. Twice a week, every inpatient's treatment sheet was collected and screened through two databases: Micromedex™ and Drug Interaction Facts™. All identified potential DDIs with a moderate or higher severity rating were recorded. Multivariate analysis was used to identify risk factors associated with DDIs.
  
  
  RESULTS
  A total of 1956 DDIs were detected in 699 treatment sheets. The prevalence of treatment sheets with DDIs was 81.0 % and 32.6 % by Micromedex™ and Drug Interaction Facts™, respectively. Central nervous depressant agents and antiemetics were the most commonly involved groups in DDIs. A higher number of non-antineoplastic drugs was related with potential DDIs [adjusted-OR 1.398 and 1.613 by Micromedex™ and Drug Interaction Facts™, respectively]. CONCLUSION The prevalence of potential DDIs was widely variable among databases. The main risk factor associated with DDIs was a higher number of non-antineoplastic medicines.
authors.affiliation: Servicio de Farmacia, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain. mafpe13@gmail.com.
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Fernández de Palencia Espinosa
authors.affiliation: Servicio de Farmacia, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
authors.forename: M Sacramento
authors.initials: MS
authors.lastname: Díaz Carrasco
authors.affiliation: Servicio de Oncología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Alonso Romero
authors.affiliation: Servicio de Farmacia, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
authors.forename: Amelia
authors.initials: A
authors.lastname: de la Rubia Nieto
authors.affiliation: Departamento de Farmacología, Universidad de Murcia, Murcia, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Espuny Miró
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000932:Antiemetics / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002492:Central Nervous System Depressants / Q000009:adverse effects; D015331:Cohort Studies; D016208:Databases, Factual; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D016522:Oncology Service, Hospital; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D062606:Tertiary Care Centers; D055815:Young Adult
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D002492:Central Nervous System Depressants
keywords: Adult; Antineoplastic agent; Drug-drug interaction; Inpatient; Spain