title: Low anti-ulcerogenic potentials of essential oils and methanolic extract of Croton zambesicus leaves.
abstract: OBJECTIVE
  This study evaluated the anti-ulcer properties of Croton zambesicus leaves.
  
  
  METHODS
  Group I was control. 40 mg/kg/bodyweight of indomethacin (the ulcerogen) was administered to rats of Groups II-VII. 4 h after administrations of ulcerogen; rats of Groups III-VII were treated daily with oral administrations of 40 mg/kg/bodyweight of omeprazole, 5 and 10 mg/kg/bodyweight of essential oils, 250 and 500 mg/kg bodyweight of methanolic extract of C. zambesicus leaves respectively for 4 days. Rats were euthanized on day 1 (Group II) and day 5 (Groups I and III-VII); thereafter, stomach and liver samples were removed for evaluations of gastric acidity, histopathological and alanine aminotransferase (ALT) status.
  
  
  RESULTS
  Analyses of gastric acid assays and histopathological examinations showed dose-dependent statistically significant higher levels (P ≤ 0.05) of gastric acidity and non-restorations of the gastric mucosa layer to pre-ulceration states in rats of Groups IV-VII treated with extract doses when compared to Group III. Statistically non-significant (Group IV) or significant (Groups V-VII) higher ALT levels (P ≤ 0.05) were observed in liver samples of rats treated with doses of essential oils and methanolic extract of C. zambesicus leaves when compared to Group II.
  
  
  CONCLUSIONS
  Our study observed low anti-ulcerogenic potentials of doses of essential oils and methanolic extracts of C. zambesicus leaves.
authors.affiliation: Department of Anatomy, University of Ilorin, Kwara State, Nigeria.
authors.forename: Adelaja Abdulazeez
authors.initials: AA
authors.lastname: Akinlolu
authors.affiliation: Department of Anatomy, University of Ilorin, Kwara State, Nigeria.
authors.forename: Ghazali Olaide
authors.initials: GO
authors.lastname: Kamaldeen
authors.affiliation: Department of Anatomy, University of Ilorin, Kwara State, Nigeria.
authors.forename: Deborah
authors.initials: D
authors.lastname: Francis
authors.affiliation: Department of Chemistry, University of Ilorin, Kwara State, Nigeria.
authors.forename: Mubarak Oloduowo
authors.initials: MO
authors.lastname: Ameen
keywords: Croton zambesicus; indomethacin; ulceration