title: Nitrogen-Containing Diterpenoids, Sesquiterpenoids, and Nor-Diterpenoids from Cespitularia taeniata.
abstract: Two new nitrogen-containing verticillene diterpenoids, cespilamides A and B (1 and 2), three new nitrogen-containing sesquiterpenoids, cespilamides C-E (3-5), and five new norverticillene and verticillene diterpenoids, cespitaenins A-E (6-10), were isolated from the Taiwanese soft coral Cespitularia taeniata. Compound 1 possesses an unusual oxazo ring system at C-10 while compound 2 displays an unprecedented C-C bond cleavage between C-10 and C-11 with an N-ethylphenyl group at C-10. Biogenetic pathways of 1 and 2 are proposed. The absolute configuration of 1 was confirmed by Mosher's method and molecular mechanics calculations (MM2). The cytotoxicities of compounds 1-10 were evaluated against a small panel of human cancer cell lines.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. aska@newbellus.com.tw.|Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan. aska@newbellus.com.tw.
authors.forename: Shih-Sheng
authors.initials: SS
authors.lastname: Wang
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. jmb@kmu.edu.tw.
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. z10108042@email.ncku.edu.tw.
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Lin
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. biogodas@hotmail.com.
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan. dryang323@gmail.com.
authors.forename: Jiun-Yang
authors.initials: JY
authors.lastname: Chang
authors.affiliation: National Research Institute of Chinese Medicine, Taipei 112, Taiwan. kuoyh@nricm.edu.tw.
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. ycshen@ntu.edu.tw.
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000378:metabolism*; D004224:Diterpenes / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes
keywords: Cespitularia taeniata; cytotoxicity; verticillene diterpenoids