title: Chemoreversal Metabolites from the Endophytic Fungus Penicillium citrinum Isolated from a Mangrove Avicennia marina.
abstract: Two new compounds, named (Z)-7,4'-dimethoxy-6-hydroxyaurone-4-O-β-glucopyranoside (1) and (-)-4-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid (2), were isolated from the endophytic fungus Penicillium citrinum of Avicennia marina. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compound 2 exhibited potent chemoreversal activity, mainly by inhibiting P-glycoprotein efflux pump function.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.forename: Meng
authors.initials: M
authors.lastname: Xu
authors.forename: Ming-yi
authors.initials: MY
authors.lastname: Zhu
authors.forename: Yun
authors.initials: Y
authors.lastname: Feng
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D032407:Avicennia / Q000382:microbiology*; D060026:Endophytes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007624:KB Cells; D010407:Penicillium / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification
chemical_list: C000602610:4-O-(4-O-beta-D-glucopyranosylcaffeoyl)quinic acid; C000602609:7,4'-dimethoxy-6-hydroxyaurone-4-O-beta-glucopyranoside; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D005960:Glucosides; D011801:Quinic Acid