title: Effects of ziprasidone, SCH23390 and SB277011 on spatial memory in the Morris water maze test in naive and MK-801 treated mice.
abstract: Introduction: Patients with schizophrenia have cognitive dysfunctions; positive psychotic symptoms are the primary purposes for schizophrenia treatment. Improvements in cognitive function should be a characteristic of all newly developed drugs for the treatment of schizophreniawith dementia. Thus,we investigated the effects of the second-generation antipsychotic ziprasidone, dopamine D1 antagonist SCH-23390 and dopamine D3 antagonist SB-277011 on spatial learning and memory. Materials and methods: Male inbred mice were used. The effects of ziprasidone, SCH-23390 and SB-277011 were investigated using the Morris water maze test. Results: Ziprasidone (0.5 and 1mg/kg), SCH-23390 (0.05 and 0.1 mg/kg) and SB-277011 (10 and 20 mg/kg) had no effect on the time spent in the target quadrant in naive mice.MK-801 (0.1mg/kg) significantly decreased the time spent in the target quadrant. The time spent in the target quadrant was significantly prolonged by Ziprasidone (0.5 and 1 mg/kg) and SCH-23390 (0.1 mg/kg), but not with SB-277011 (20 mg/kg) in MK-801-treated mice. Ziprasidone (0.5 and 1mg/kg), SCH-23390 (0.05 and 0.1 mg/kg) and SB-277011 (10 and 20 mg/kg) had no effect on themean distance to the platformin naivemice.MK-801 significantly increased themean distance to the platform. Ziprasidone (1 mg/kg) and SCH-23390 (0.1 mg/kg) significantly decreased the mean distance to the platform in MK-801-treated mice, but SB-277011 (20 mg/kg) didn't. MK-801 significantly increased the total distance moved. Ziprasidone (0.5 and 1 mg/kg), SCH-23390 (0.05 and 0.1 mg/kg) and SB-277011 (10 and 20 mg/kg) had no effect on the total distance moved in naive mice. Ziprasidone (1 mg/kg) and SCH-23390 (0.1 mg/kg) significantly decreased the total distance moved in MK-801-treated mice, but SB-277011 (20 mg/kg) didn't. Conclusions: The second-generation antipsychotic drug ziprasidone and D1 antagonist SCH23390, but not the D3 antagonist SB277011, might be clinically useful for the treatment of cognitive impairments in patients with schizophrenia.
authors.affiliation: Sakarya University, Faculty of Medicine, Department of Pharmacology, 54100 Sakarya, Turkey. Electronic address: pelintanyeri@yahoo.com.
authors.forename: Pelin
authors.initials: P
authors.lastname: Tanyeri
authors.affiliation: Sakarya University, Faculty of Medicine, Department of Pharmacology, 54100 Sakarya, Turkey. Electronic address: mebuyukokuroglu@yahoo.com.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Buyukokuroglu
authors.affiliation: Kocaeli University, Faculty of Medicine, Department of Pharmacology, 41380 Kocaeli, Turkey. Electronic address: oguzmutlu80@hotmail.com.
authors.forename: Oguz
authors.initials: O
authors.lastname: Mutlu
authors.affiliation: Kocaeli University, Faculty of Medicine, Department of Pharmacology, 41380 Kocaeli, Turkey. Electronic address: gunerulak@yahoo.com.
authors.forename: Güner
authors.initials: G
authors.lastname: Ulak
authors.affiliation: Kocaeli University, Faculty of Medicine, Department of Pharmacology, 41380 Kocaeli, Turkey. Electronic address: firuzanakar@gmail.com.
authors.forename: Füruzan Yildiz
authors.initials: FY
authors.lastname: Akar
authors.affiliation: Kocaeli University, Faculty of Medicine, Department of Pharmacology, 41380 Kocaeli, Turkey. Electronic address: ikcelikyurt@gmail.com.
authors.forename: Ipek Komsuoglu
authors.initials: IK
authors.lastname: Celikyurt
authors.affiliation: Kocaeli University, Faculty of Medicine, Department of Pharmacology, 41380 Kocaeli, Turkey. Electronic address: faruk.erden@isbank.net.tr.
authors.forename: Bekir Faruk
authors.initials: BF
authors.lastname: Erden
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects; D009570:Nitriles / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D065852:Spatial Memory / Q000187:drug effects*; D044005:Tetrahydroisoquinolines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D014150:Antipsychotic Agents; D001552:Benzazepines; D018691:Excitatory Amino Acid Antagonists; D009570:Nitriles; D010879:Piperazines; C409982:SB 277011; C534628:SCH 23390; D044005:Tetrahydroisoquinolines; D013844:Thiazoles; D016291:Dizocilpine Maleate; C092292:ziprasidone
keywords: Cognition; MK-801; Mice; Morris water maze; SB277011; SCH23390; Ziprasidone