title: Study of thein vitrocytotoxicity testing of medical devices.
abstract: The cytotoxicity test is one of the biological evaluation and screening tests that use tissue cellsin vitroto observe the cell growth, reproduction and morphological effects by medical devices. Cytotoxicity is preferred as a pilot project test and an important indicator for toxicity evaluation of medical devices as it is simple, fast, has a high sensitivity and can save animals from toxicity. Three types of cytotoxicity test are stated in the International Organization for Standardization 109993-5: Extract, direct contact and indirect contact tests. The xCELLigence real-time cell analysis system shows a significant potential in regards to cytotoxicity in recent years. The present review provides a brief insight into thein vitrocytotoxicity testing of medical devices.
authors.affiliation: Henan Province Institute for Medical Equipment Testing, Zhengzhou, Henan 450003, P.R. China.
authors.forename: Weijia
authors.initials: W
authors.lastname: Li
authors.affiliation: Henan Province Institute for Medical Equipment Testing, Zhengzhou, Henan 450003, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Henan Province Institute for Medical Equipment Testing, Zhengzhou, Henan 450003, P.R. China.
authors.forename: Yuyin
authors.initials: Y
authors.lastname: Xu
keywords: biocompatibility; cytotoxicity; medical devices; xCELLigence