title: Alterations of EEG functional connectivity in resting state obese and overweight patients with binge eating disorder: A preliminary report.
abstract: Alterations in brain functional connectivity have been detected in patients with eating disorders, but have not been studied in binge eating disorder (BED). We have investigated electroencephalographic (EEG) functional connectivity in thirteen overweight and obese patients with BED and thirteen overweight and obese patients without BED during RS condition. EEG analyzes were conducted by means of the exact Low Resolution Electric Tomography software (eLORETA). Compared to patients without BED, patients with BED demonstrated an increase of lagged phase synchronization in the beta frequency band among the cortical areas explored by FC1-T3 (left superior frontal gyrus-left middle temporal gyrus), T5-O1 (left inferior temporal gyrus-left middle occipital gyrus), and C4-O1 (right postcentral gyrus-left middle occipital gyrus) electrodes (T=4.861, p<0.05). EEG connectivity values were also significantly related to binge eating symptomatology after controlling for depressive symptoms. Our results may reflect the impairment of frontal control network and visual processing networks, which lead patients with BED to be more vulnerable to food cues and lack of control with regards to over eating.
authors.affiliation: Department of Human Sciences, European University, Rome, Italy. Electronic address: imperatori.c@libero.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Imperatori
authors.affiliation: Department of Human Sciences, European University, Rome, Italy.
authors.forename: Mariantonietta
authors.initials: M
authors.lastname: Fabbricatore
authors.affiliation: Department of Human Sciences, European University, Rome, Italy.
authors.forename: Benedetto
authors.initials: B
authors.lastname: Farina
authors.affiliation: Department of Human Sciences, European University, Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Innamorati
authors.affiliation: Department of Human Sciences, European University, Rome, Italy.
authors.forename: Maria Isabella
authors.initials: MI
authors.lastname: Quintiliani
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Dorian A
authors.initials: DA
authors.lastname: Lamis
authors.affiliation: Department of Human Sciences, European University, Rome, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Contardi
authors.affiliation: Institute of Neurology, Catholic University, Rome, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Della Marca
authors.affiliation: Department of Dynamic and Clinical Psychology, Sapienza University, Rome, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Speranza
mesh_terms: D000328:Adult; D056912:Binge-Eating Disorder / Q000150:complications / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D050177:Overweight / Q000150:complications / Q000503:physiopathology*; D012146:Rest
keywords: Binge eating disorder; EEG functional connectivity; Obesity; Overweight; eLORETA