title: Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres.
abstract: A chitosan-based hydrophilic system containing an olive leaf extract was designed and its antioxidant capacity was evaluated. Encapsulation of olive leaf extract in chitosan microspheres was carried out by a spray-drying process. The particles obtained with this technique were found to be spherical and had a positive surface charge, which is an indicator of mucoadhesiveness. FTIR and X-ray diffraction results showed that there are not specific interactions of polyphenolic compounds in olive leaf extract with the chitosan matrix. Stability and release studies of chitosan microspheres loaded with olive leaf extract before and after the incorporation into a moisturizer base were performed. The resulting data showed that the developed formulations were stable up to three months. The encapsulation efficiency was around 44% and the release properties of polyphenols from the microspheres were found to be pH dependent. At pH 7.4, polyphenols release was complete after 6 h; whereas the amount of polyphenols released was 40% after the same time at pH 5.5.
authors.affiliation: Department of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, Spain. facosta@ucm.es.
authors.forename: Niuris
authors.initials: N
authors.lastname: Acosta
authors.affiliation: Department of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, Spain. elisas01@ucm.es.
authors.forename: Elisa
authors.initials: E
authors.lastname: Sánchez
authors.affiliation: Department of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, Spain. lcaldero@ucm.es.
authors.forename: Laura
authors.initials: L
authors.lastname: Calderón
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Industrial Pharmacy, Complutense University, Plaza Severo Ochoa s/n., Madrid 28040, Spain. mcordoba@ucm.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Cordoba-Diaz
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Industrial Pharmacy, Complutense University, Plaza Severo Ochoa s/n., Madrid 28040, Spain. damianco@ucm.es.
authors.forename: Damián
authors.initials: D
authors.lastname: Cordoba-Diaz
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Industrial Pharmacy, Complutense University, Plaza Severo Ochoa s/n., Madrid 28040, Spain. sene_dom@hotmail.com.
authors.forename: Senne
authors.initials: S
authors.lastname: Dom
authors.affiliation: Department of Physical Chemistry II, Faculty of Pharmacy, Institute of Biofunctional Studies, Complutense University, Paseo Juan XXIII nº 1, Madrid 28040, Spain. aheras@ucm.es.
authors.forename: Ángeles
authors.initials: Á
authors.lastname: Heras
mesh_terms: D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004355:Drug Stability; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D031658:Olea / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D048271:Chitosan
keywords: antioxidant encapsulation; chitosan; semi-solid formulation; spray-drying