title: The role of the skin microbiome in atopic dermatitis.
abstract: Atopic dermatitis (AD) is a common skin disease that affects a large proportion of the population worldwide. The incidence of AD has increased over the last several decades along with AD's burden on the physical and psychological health of the patient and family. However, current advances in understanding the mechanisms behind the pathophysiology of AD are leading to a hopeful outlook for the future. Staphylococcus aureus (S. aureus) colonization on AD skin has been directly correlated to disease severity but the functions of other members of the skin bacterial community may be equally important. Applying knowledge gained from understanding the role of the skin microbiome in maintaining normal skin immune function, and addressing the detrimental consequences of microbial dysbiosis in driving inflammation, is a promising direction for development of new treatments. This review discusses current preclinical and clinical research focused on determining how the skin microbiome may influence the development of AD.
authors.affiliation: Department of Dermatology, University of California San Diego, 9500 Gillman Dr., #0869, La Jolla, CA, 92093, USA. mrw006@ucsd.edu.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Williams
authors.affiliation: Department of Dermatology, University of California San Diego, 9500 Gillman Dr., #0869, La Jolla, CA, 92093, USA. rgallo@ucsd.edu.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Gallo
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D064307:Microbiota; D012720:Severity of Illness Index; D012867:Skin / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology / Q000472:pathogenicity; D014774:Virulence
keywords: Atopic dermatitis; Dysbiosis; Skin microbiome; Staphylococcus aureus; Staphylococcus epidermidis; Virulence factors