title: Structural Magnetic Resonance Imaging Markers of Alzheimer's Disease and Its Retranslation to Rodent Models.
abstract: The importance of imaging biomarkers has been acknowledged in the diagnosis and in the follow-up of Alzheimer's disease (AD), one of the major causes of dementia. Next to the molecular biomarkers and PET imaging investigations, structural MRI approaches provide important information about the disease progression and about the pathomechanism. Furthermore,a growing body of literature retranslates these imaging biomarkers to various rodent models of the disease. The goal of this review is to provide an overview of the macro- and microstructural imaging biomarkers of AD, concentrating on atrophy measures and diffusion MRI alterations. A survey is also given of the imaging approaches used in rodent models of dementias that can promote drug development.
authors.affiliation: Department of Neurology, University of Szeged, Szeged, Hungary.|International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
authors.forename: Zsigmond Tamas
authors.initials: ZT
authors.lastname: Kincses
authors.affiliation: Department of Neurology, University of Szeged, Szeged, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Király
authors.affiliation: Department of Neurology, University of Szeged, Szeged, Hungary.
authors.forename: Dániel
authors.initials: D
authors.lastname: Veréb
authors.affiliation: Department of Neurology, University of Szeged, Szeged, Hungary.|MTA-SZTE Neuroscience Research Group, Szeged, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Vécsei
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D011877:Radionuclide Imaging
chemical_list: D015415:Biomarkers
keywords: Alzheimer’s disease; diffusion tensor imaging; magnetic resonance imaging; rodent model