title: AVE 0991 attenuates cardiac hypertrophy through reducing oxidative stress.
abstract: AVE 0991, the nonpeptide angiotensin-(1-7) (Ang-(1-7)) analog, is recognized as having beneficial cardiovascular effects. However, the mechanisms have not been fully elucidated. This study was designed to investigate the effects of AVE 0991 on cardiac hypertrophy and the mechanisms involved. Mice were underwent aortic banding to induce cardiac hypertrophy followed by the administration of AVE 0991 (20 mg kg·day (-1)) for 4 weeks. It was shown that AVE 0991 reduced left ventricular hypertrophy and improved heart function, characterized by decreases in left ventricular weight and left ventricular end-diastolic diameter, and increases in ejection fraction. Moreover, AVE 0991 significantly down-regulated mean myocyte diameter and attenuate the gene expression of the hypertrophic markers. Furthermore, AVE 0991 inhibited the expression of NOX 2 and NOX 4, meaning that AVE 0991 reduced oxidative stress of cardiac hypertrophy mice. Our data showed that AVE 0991 treatment could attenuate cardiac hypertrophy and improve heart function, which may be due to reduce oxidative stress.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, PR China.
authors.forename: Yuedong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, PR China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, PR China.
authors.forename: Jingzhou
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, PR China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, PR China.
authors.forename: Chunxi
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, PR China.
authors.forename: Anli
authors.initials: A
authors.lastname: Tang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Dai
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, PR China. Electronic address: hejiangui@163.com.
authors.forename: Jiangui
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, PR China. Electronic address: 3160992650@qq.com.
authors.forename: Yili
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000503:physiopathology* / Q000517:prevention & control*; D007093:Imidazoles / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000187:drug effects*; D013318:Stroke Volume / Q000187:drug effects; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*
chemical_list: C469726:AVE 0991; D002316:Cardiotonic Agents; D007093:Imidazoles
keywords: AVE 0991; Cardiac hypertrophy; Oxidative stress; Pressure overload