title: [ANALYSIS OF THE RESULTS OF ENDOSCOPIC AND MORPHOLOGICAL STUDIES OF THE STOMACH MUCOSA WITH REDUCED PEPSINOGEN-I IN PATIENTS WITH H. PYLORI (H.P.)--ASSOCIATED GASTRITIS IN TOMSK AND TOMSK REGION].
abstract: OBJECTIVE
  To explore and describe the endoscopic picture of HP--associated atrophic gastritis and to analyze the specificity of endoscopic markers indicating the presence of atrophic gastritis, intestinal metaplasia and dysplasia using high-tech methods of endoscopy in comparison with morphological characteristics of atrophic gastritis defining the degree of activity and stage of atrophic gastritis according to the system OLGA.
  
  
  METHODS
  40 people: males and females aged 40 to 70 years with a reduced level of pepsinogen I and a positive titre of antibodies to H. pylori in serum--were included into the study.
  
  
  RESULTS
  Risk groups with atrophic gastritis based on indicators of pepsinogen 1 were formed. Endoscopic picture of H. Pylori--associated atrophic gastritis in patients with reduced level of pepsinogen I in serum is studied and described. Analysis of the specificity of endoscopic markers indicating the presence of AG, intestinal metaplasia and dysplasia using high-tech methods of endoscopy (endoscopy with high resolution, magnifying endoscopy, chromoendoscopy and narrow band imaging endoscopy (NBI) is made. Analysis of their sensitivity in comparison with the results of morphological studies of biopsy material is made.
  
  
  CONCLUSIONS
  Thus, these studies show that high-resolution endoscopy in combination with magnification and chromoendoscopy allows accurately identify areas of atrophy, intestinal.Narrow band imaging endoscopy (NBI) provides a detailed picture of the vascular pattern of tissues, pattern changes typical for pathological areas of inflammatory genesis, as well as for precancers and early cancers. All these methods have high sensitivity and specificity in the diagnosis of HP-associated atrophic gastritis in comparison with the results of morphological studies of biopsy materials of stomach mucosa.
authors.forename: E V
authors.initials: EV
authors.lastname: Beloborodova
authors.forename: I L
authors.initials: IL
authors.lastname: Purlik
authors.forename: N A
authors.initials: NA
authors.lastname: Li
authors.forename: M I
authors.initials: MI
authors.lastname: Rachkovskiy
authors.forename: M S
authors.initials: MS
authors.lastname: Sanzharovskaya
mesh_terms: D000328:Adult; D000368:Aged; D002947:Cities; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000097:blood / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D005773:Gastroscopy / Q000379:methods*; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008679:Metaplasia; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D012426:Russia / Q000453:epidemiology; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000382:microbiology / Q000473:pathology
chemical_list: D020116:Pepsinogen A