title: The efficacy of different doses of solifenacin in elderly patients after treating a urinary tract infection.
abstract: OBJECTIVE
  To determine the efficacy and safety of solifenacin for correcting the residual symptoms of an overactive bladder (OAB) in patients who were treated for a urinary tract infection (UTI).
  
  
  METHODS
  Using random sampling, 524 patients aged >60 years were selected (347 women, 66.2%, and 177 men, 33.8%). They denied the presence of any symptoms of detrusor overactivity in their medical history, but had a diagnosis of a UTI. At least 1 month after the end of treatment and a laboratory confirmation of the absence of infection, each patient completed an OAB-Awareness Tool questionnaire (OAB signs, total score 8 points), and a noninvasive examination of urinary function (uroflowmetry). Each day patients in group A took solifenacin 10 mg and those in group B took 5 mg, with patients in group C being given a placebo.
  
  
  RESULTS
  During the study 58.8% of patients had symptoms of an OAB at 1 month after the end of the treatment for a UTI, and normal laboratory markers. During treatment with the standard and higher dose of solifenacin, within 8 weeks most variables of the condition of the lower urinary tract reached a normal state or improved.
  
  
  CONCLUSIONS
  Patients aged >60 years who had been treated for a UTI have a high risk of developing symptoms of an OAB. Solifenacin in standard doses is an efficient and safe means of managing overactive detrusor symptoms after a UTI.
authors.affiliation: School of Humanities, Far Eastern Federal University, Russian Federation.
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Kosilov
authors.affiliation: Department of Urology, City Polyclinic No. 3, Russian Federation.
authors.forename: Sergay A
authors.initials: SA
authors.lastname: Loparev
authors.affiliation: Far Eastern Fisheries University, Russian Federation.
authors.forename: Marina A
authors.initials: MA
authors.lastname: Ivanovskaya
authors.affiliation: Department of the Functional Methods of Examination, Medical Association No. 2 of Vladivostok City, Vladivostok, Primorsky Region, Russian Federation.
authors.forename: Liliya V
authors.initials: LV
authors.lastname: Kosilova
keywords: Elderly men; IE, incontinence episodes; LUT, lower urinary tract; OAB, overactive bladder; OAB-AT, OAB Awareness Tool (questionnaire); Overactive bladder; Solifenacin; UE, urgency episodes; Urinary tract infection