title: Antigenic and molecular characterisation of Border disease virus associated with high mortality in lambs in Spain.
abstract: BACKGROUND
  Border disease virus (BDV) causes congenital disorders in sheep and results in severe, but underestimated, economic losses worldwide. However, information about BDV strains affecting several ruminants worldwide is scarce. Therefore, antigenic and genetic classification of isolates from different geographical regions is important to enhance the knowledge of the epidemiology of BDV.
  
  
  METHODS
  Five pestiviruses isolated from lambs in an epidemic outbreak with an unusually high mortality in Spain in 1997 were characterised antigenically with a panel of monoclonal antibodies and genetically by sequencing within the 50 untranslated (50UTR) region of the genome.
  
  
  RESULTS
  All the isolates were classified as BDV and showed a high homology with the Aveyron strain (Av), which was associated with an epidemic reported in sheep from the Aveyron region of France in 1984.
  
  
  CONCLUSIONS
  Classification of the isolates from this study provides valuable information on the molecular epidemiology of BDV.
authors.affiliation: Facultad de Veterinaria, Departamento de Producción y Sanidad Animal , Salud Pública Veterinaria, Ciencia y Tecnología de los Alimentos, Universidad CEU Cardenal Herrera , Valencia , Spain.
authors.forename: S
authors.initials: S
authors.lastname: Vega
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona , Barcelona , Spain ; Departament d'Agricultura, Ramaderia, Pesca , Alimentació i Medi Natural, Generalitat de Catalunya.
authors.forename: R
authors.initials: R
authors.lastname: Rosell
authors.affiliation: Facultad de Veterinaria, Departamento de Sanidad Animal , Universidad Complutense , Madrid , Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Orden
authors.affiliation: Facultad de Farmacia, Departamento de Farmacia , Universidad CEU Cardenal Herrera , Valencia , Spain.
authors.forename: T
authors.initials: T
authors.lastname: Pérez
authors.affiliation: Facultad de Veterinaria, Departamento de Producción y Sanidad Animal , Salud Pública Veterinaria, Ciencia y Tecnología de los Alimentos, Universidad CEU Cardenal Herrera , Valencia , Spain.
authors.forename: C
authors.initials: C
authors.lastname: Marín
authors.affiliation: Facultad de Veterinaria, Departamento de Producción y Sanidad Animal , Salud Pública Veterinaria, Ciencia y Tecnología de los Alimentos, Universidad CEU Cardenal Herrera , Valencia , Spain.
authors.forename: S
authors.initials: S
authors.lastname: González
authors.affiliation: Servei d'Ecopatologia de Fauna Salvatge (SEFaS), Facultat de Veterinaria, Departament de Medicina i Cirurgia Animals , Universitat Autònoma de Barcelona , Barcelona , Spain.
authors.forename: I
authors.initials: I
authors.lastname: Marco
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona , Barcelona , Spain ; Servei d'Ecopatologia de Fauna Salvatge (SEFaS), Facultat de Veterinaria, Departament de Medicina i Cirurgia Animals , Universitat Autònoma de Barcelona , Barcelona , Spain.
authors.forename: O
authors.initials: O
authors.lastname: Cabezón
authors.affiliation: Facultad de Veterinaria, Departamento de Sanidad Animal , Universidad Complutense , Madrid , Spain.
authors.forename: R
authors.initials: R
authors.lastname: de la Fuente