title: Itches-stimulating compounds from Colocasia esculenta (taro): bioactive-guided screening and LC-MS/MS identification.
abstract: Colocasia esculenta (L.) Schoot (taro) is one of the most common crops in the world. Its rhizome was a tonic medicine and accustomed to treat some gastrointestinal disorders in traditional Chinese medicine. Today, the taro was further developed as anticancer prescription in herbal therapy. However, the mucilage of the fresh taro has irritation, and causes itchy feeling. The components in the mucilage were not evident up to now. Two active compounds, uracil and glycol-protein taro lectin (Accession number: A5HMM7), were purified and identified from the fresh taro. The glycol-protein taro lectin showed nerve stimulation activity on dorsal root ganglion (DRG) neurons from GCaMP transgenic mice at the concentration of 1mg/mL.
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.
authors.forename: Jin-Gao
authors.initials: JG
authors.lastname: Yu
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China. Electronic address: liupei@njucm.edu.cn.
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.affiliation: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China. Electronic address: dja@njucm.edu.cn.
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
authors.affiliation: College of Basic Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.
authors.forename: Zong-Xiang
authors.initials: ZX
authors.lastname: Tang
authors.affiliation: College of Basic Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid; D031060:Colocasia / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005727:Ganglia, Spinal / Q000187:drug effects; D037102:Lectins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D008822:Mice, Transgenic; D008958:Models, Molecular; D009474:Neurons / Q000187:drug effects; D011537:Pruritus / Q000139:chemically induced*; D013329:Structure-Activity Relationship; D053719:Tandem Mass Spectrometry; D014498:Uracil / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D037102:Lectins; D014498:Uracil
keywords: Colocasia esculenta; Itch; Lectin; Uracil