title: Clonality of neutrophilia associated with plasma cell neoplasms: report of a SETBP1 mutation and analysis of a single institution series.
abstract: A rare but well-known association between plasma cell neoplasms and neutrophilia is known to exist. Whether the neutrophilia is secondary to the plasma cell neoplasm or this convergence represents two independent clonal disorders is unclear. We reviewed five consecutive cases from a single institution over a 3-year period, applying molecular, cytogenetic and cytokine-profiling approaches to determine whether neutrophilia associated with plasma cell neoplasms represents a reactive or clonal process. We report, for the first time, the occurrence of a SETBP1 mutation in two cases, as well as changes in G-CSF and IL-6 in SETBP1 wild type vs. mutated patients that are supportive of a hypothesis that neutrophilia associated with plasma cell neoplasms may sometimes be reactive and may sometimes represent a second clonal entity. Finally, using an ex vivo drug screening platform we report the potential efficacy of the multi-kinase inhibitor dasatinib in select patients.
authors.affiliation: a Division of Hematology , University of Colorado , Aurora , CO , USA ;
authors.forename: Brett
authors.initials: B
authors.lastname: Stevens
authors.affiliation: b Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA ;|c Division of Oncology , Oregon Health Science University , Portland , OR , USA ;
authors.forename: Julia
authors.initials: J
authors.lastname: Maxson
authors.affiliation: c Division of Oncology , Oregon Health Science University , Portland , OR , USA ;
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tyner
authors.affiliation: a Division of Hematology , University of Colorado , Aurora , CO , USA ;
authors.forename: Clayton A
authors.initials: CA
authors.lastname: Smith
authors.affiliation: a Division of Hematology , University of Colorado , Aurora , CO , USA ;
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Gutman
authors.affiliation: a Division of Hematology , University of Colorado , Aurora , CO , USA ;
authors.forename: William
authors.initials: W
authors.lastname: Robinson
authors.affiliation: a Division of Hematology , University of Colorado , Aurora , CO , USA ;
authors.forename: Craig T
authors.initials: CT
authors.lastname: Jordan
authors.affiliation: d San Juan Cancer Center , Montrose , CO , USA ;
authors.forename: Choon-Kee
authors.initials: CK
authors.lastname: Lee
authors.affiliation: e Department of Pathology , University of Colorado , Aurora , CO , USA ;
authors.forename: Karen
authors.initials: K
authors.lastname: Swisshelm
authors.affiliation: f School of Pharmacy, University of Colorado , Aurora , CO , USA ;
authors.forename: Jennifer
authors.initials: J
authors.lastname: Tobin
authors.affiliation: g Department of Pediatrics , University of Colorado , Aurora , CO , USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wei
authors.affiliation: e Department of Pathology , University of Colorado , Aurora , CO , USA ;
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Schowinsky
authors.affiliation: a Division of Hematology , University of Colorado , Aurora , CO , USA ;
authors.forename: Sean
authors.initials: S
authors.lastname: Rinella
authors.affiliation: a Division of Hematology , University of Colorado , Aurora , CO , USA ;
authors.forename: Hea Gie
authors.initials: HG
authors.lastname: Lee
authors.affiliation: a Division of Hematology , University of Colorado , Aurora , CO , USA ;
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Pollyea
mesh_terms: D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics*; D002869:Chromosome Aberrations; D060965:Clonal Evolution; D016207:Cytokines / Q000378:metabolism; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007964:Leukocytosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D054219:Neoplasms, Plasma Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology*; D009687:Nuclear Proteins / Q000235:genetics*; D012189:Retrospective Studies
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; D009687:Nuclear Proteins; C425066:SETBP1 protein, human
keywords: Chronic neutrophilic leukemia; SETBP1; neutrophilia; plasma cell neoplasm