title: Novel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effect.
abstract: To develop a novel neomycin sulfate-loaded hydrogel dressing (HD), numerous neomycin sulfate-loaded HDs were prepared with various amounts of polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) and sodium alginate (SA) using freeze-thawing technique, and their physical dressing properties, drug release, in vivo wound curing and histopathology in diabetic-induced rats were assessed. SA had a positive effect on a swelling capacity, but a negative effect on the physical dressing properties and drug release of HD. However, PVP did the opposite. In particular, the neomycin sulfate-loaded HD composed of drug, PVA, PVP and SA at the weight ratio of 1/10/0.8/0.8 had excellent swelling and bioadhesive capacity, good elasticity and fast drug release. Moreover, this HD gave more improved wound curing effect compared to the commercial product, ensured the disappearance of granulation tissue and recovered the wound tissue to normal. Therefore, this novel neomycin sulfate-loaded HD could be an effective pharmaceutical product for the treatment of wounds.
authors.affiliation: a College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University , Ansan , South Korea.
authors.forename: Jong Seo
authors.initials: JS
authors.lastname: Choi
authors.affiliation: a College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University , Ansan , South Korea.
authors.forename: Dong Wuk
authors.initials: DW
authors.lastname: Kim
authors.affiliation: a College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University , Ansan , South Korea.
authors.forename: Dong Shik
authors.initials: DS
authors.lastname: Kim
authors.affiliation: b College of Pharmacy, Yeungnam University , Gyongsan , South Korea.
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Kim
authors.affiliation: b College of Pharmacy, Yeungnam University , Gyongsan , South Korea.
authors.forename: Chul Soon
authors.initials: CS
authors.lastname: Yong
authors.affiliation: c College of Pharmacy, Inje University , Gimhae , South Korea , and.
authors.forename: Kwan Hyung
authors.initials: KH
authors.lastname: Cho
authors.affiliation: d School of Pharmacy, Sungkyunkwan University , Suwon , South Korea.
authors.forename: Yu Seok
authors.initials: YS
authors.lastname: Youn
authors.affiliation: a College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University , Ansan , South Korea.
authors.forename: Sung Giu
authors.initials: SG
authors.lastname: Jin
authors.affiliation: a College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University , Ansan , South Korea.
authors.forename: Han-Gon
authors.initials: HG
authors.lastname: Choi
mesh_terms: D000464:Alginates / Q000737:chemistry; D000818:Animals; D001458:Bandages; D065546:Drug Liberation / Q000502:physiology; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage* / Q000737:chemistry*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009355:Neomycin / Q000008:administration & dosage* / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D011145:Polyvinyls; D011759:Pyrrolidines; C505150:poly(N-vinylpyrrolidine); D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol; D009355:Neomycin
keywords: Histological examination; hydrogel dressing; neomycin sulfate; polyvinyl alcohol; polyvinyl pyrrolidone; sodium alginate; wound-curing effect