title: Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans.
abstract: In the walls of the lateral ventricles of the adult mammalian brain, neural stem cells (NSCs) and ependymal (E1) cells share the apical surface of the ventricular-subventricular zone (V-SVZ). In a recent article, we show that supraependymal serotonergic (5HT) axons originating from the raphe nuclei in mice form an extensive plexus on the walls of the lateral ventricles where they contact E1 cells and NSCs. Here we further characterize the contacts between 5HT supraependymal axons and E1 cells in mice, and show that suprependymal axons tightly associated to E1 cells are also present in the walls of the human lateral ventricles. These observations raise interesting questions about the function of supraependymal axons in the regulation of E1 cells.
authors.affiliation: Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research; University of California San Francisco; San Francisco, CA USA ; Neuroscience Graduate Program; University of California San Francisco; San Francisco, CA USA.
authors.forename: Cheuk Ka
authors.initials: CK
authors.lastname: Tong
authors.affiliation: Laboratory of Comparative Neurobiology; Instituto Cavanilles; Universidad de Valencia; CIBER NED; Valencia, Spain.
authors.forename: Arantxa
authors.initials: A
authors.lastname: Cebrián-Silla
authors.affiliation: Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research; University of California San Francisco; San Francisco, CA USA ; Department of Neurology; University of California San Francisco; San Francisco, CA USA.
authors.forename: Mercedes F
authors.initials: MF
authors.lastname: Paredes
authors.affiliation: Neuroscience Graduate Program; University of California San Francisco; San Francisco, CA USA ; Department of Pathology; University of California San Francisco; San Francisco, CA USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Huang
authors.affiliation: Laboratory of Comparative Neurobiology; Instituto Cavanilles; Universidad de Valencia; CIBER NED; Valencia, Spain ; Unidad Mixta de Esclerosis Múltiple y Neurorregeneración; II S Hospital La Fe; Valencia, Spain.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: García-Verdugo
authors.affiliation: Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research; University of California San Francisco; San Francisco, CA USA ; Neuroscience Graduate Program; University of California San Francisco; San Francisco, CA USA.
authors.forename: Arturo
authors.initials: A
authors.lastname: Alvarez-Buylla
keywords: adult neurogenesis; ependymal cells; human; neural stem cells; serotonin; supraependymal axons