title: Comparison of the Anti-Adhesion Activity of Three Different Cranberry Extracts on Uropathogenic P-fimbriated Escherichia coli: a Randomized, Double-blind, Placebo Controlled, Ex Vivo, Acute Study.
abstract: Research suggests that cranberry (Vaccinium macrocarpon) helps maintain urinary tract health. Bacterial adhesion to the uroepithelium is the initial step in the progression to development of a urinary tract infection. The bacterial anti-adhesion activity of cranberry proanthocyanidins (PACs) has been demonstrated in vitro. Three different cranberry extracts were developed containing a standardized level of 36 mg of PACs. This randomized, double-blind, placebo controlled, ex vivo, acute study was designed to compare the anti-adhesion activity exhibited by human urine following consumption of three different cranberry extracts on uropathogenic P-fimbriated Escherichia coli in healthy men and women. All three cranberry extracts significantly increased anti-adhesion activity in urine. from 6 to 12 hours after intake of a single dose standardized to deliver 36 mg of PACs (as measured by the BL-DMAC method), versus placebo.
authors.forename: Amy
authors.initials: A
authors.lastname: Howell
authors.forename: Dan
authors.initials: D
authors.lastname: Souza
authors.forename: Marc
authors.initials: M
authors.lastname: Roller
authors.forename: Emilie
authors.initials: E
authors.lastname: Fromentin
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects; D004311:Double-Blind Method; D004927:Escherichia coli Infections / Q000517:prevention & control; D064368:Healthy Volunteers; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000517:prevention & control; D056689:Uropathogenic Escherichia coli / Q000187:drug effects; D029799:Vaccinium macrocarpon; D006801:Humans; D008297:Male; D005260:Female
chemical_list: D010936:Plant Extracts