title: Comparison of ApoE-related brain connectivity differences in early MCI and normal aging populations: an fMRI study.
abstract: In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) scans from subjects with early mild cognitive impairment (EMCI) and control subjects to study functional network connectivity. The scans were acquired by the Alzheimer's Disease Neuroimaging Initiative (ADNI). We used genetic data from the ADNI database to further subdivide the EMCI and control groups into genotype groups with or without the Apolipoprotein E allele e4 (APOE e4). Region of interest (ROI)-to-ROI resting-state functional connectivity was measured using Freesurfer and the Functional Connectivity Toolbox for Matlab (CONN). In our analysis, we compared whole-brain ROI connectivity strength and ROI-to-ROI functional network connectivity strength between EMCI, control and genotype subject groups. We found that the ROI network properties were disrupted in EMCI and APOE e4 carrier groups. Notably, we show that (1) EMCI disrupts functional connectivity strength in many important functionally-linked areas; (2) APOE e4 disrupts functional connectivity strength in similar areas to EMCI; and (3) the differences in functional connectivity between groups shows a multifactor contribution to functional network dysfunction along the trajectory leading to dementia.
authors.affiliation: Bioimaging Program, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118, USA. faye.mckenna@ucsf.edu.
authors.forename: Faye
authors.initials: F
authors.lastname: McKenna
authors.affiliation: Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord Street, Boston, MA, 02118, USA.
authors.forename: Bang-Bon
authors.initials: BB
authors.lastname: Koo
authors.affiliation: Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord Street, Boston, MA, 02118, USA.|Center for Biomedical Imaging Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Killiany
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000502:physiology*; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D053327:Apolipoprotein E4 / Q000235:genetics*; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology* / Q000503:physiopathology*; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D066264:Datasets as Topic; D005260:Female; D005500:Follow-Up Studies; D060005:Genotyping Techniques; D006579:Heterozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology; D009483:Neuropsychological Tests; D012146:Rest
chemical_list: D053327:Apolipoprotein E4
keywords: APOE e4; Dementia; EMCI; RS-fMRI