title: Advanced physiological roles of guanidinoacetic acid.
abstract: Dietary guanidinoacetic acid (GAA) seems to improve cellular bioenergetics by stimulating creatine biosynthesis. However, GAA could have other biological functions that might affect its possible use as a food ingredient in human nutrition. In this paper, we identified several alternative physiological roles of supplemental GAA, including the stimulation of hormonal release and neuromodulation, an alteration of metabolic utilization of arginine, and an adjustment of oxidant-antioxidant status. A better knowledge of how GAA affects human physiology may facilitate its use as an experimental nutritional intervention for novel purposes and conditions.
authors.affiliation: Biomedical Sciences Department, Faculty of Sport and Physical Education, University of Novi Sad, Lovcenska 16, 21000, Novi Sad, Serbia. sergej.ostojic@chess.edu.rs.|University of Belgrade School of Medicine, Belgrade, Serbia. sergej.ostojic@chess.edu.rs.
authors.forename: Sergej M
authors.initials: SM
authors.lastname: Ostojic
mesh_terms: D001120:Arginine / Q000008:administration & dosage; D004032:Diet; D019587:Dietary Supplements; D004734:Energy Metabolism / Q000187:drug effects; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans
chemical_list: D001120:Arginine; C004946:glycocyamine; D005998:Glycine
keywords: Arginine; Creatine; Guanidinoacetic acid; Insulin; Pro-oxidant