title: Regulation of Dendritic Cell Function by Vitamin D.
abstract: Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will provide an overview of Vitamin D metabolism, a description of dendritic cell subsets, and highlight recent advances on the effects of vitamin D on dendritic cell function, maturation, cytokine production and antigen presentation. The active form of vitamin D, 1,25(OH)₂D₃, has important immunoregulatory and anti-inflammatory effects. Specifically, the 1,25(OH)₂D₃-Vitamin D₃ complex can affect the maturation and migration of many dendritic cell subsets, conferring a special immunoregulatory role as well as tolerogenic properties affecting cytokine and chemokine production. Furthermore, there have been many recent studies demonstrating the effects of Vitamin D on allergic disease and autoimmunity. A clear understanding of the effects of the various forms of Vitamin D will provide new opportunities to improve human health.
authors.affiliation: Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA. Myriam.Barragan@bcm.edu.|Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA. Myriam.Barragan@bcm.edu.|Department of Pediatrics, School of Medicine, University of Pittsburgh Pittsburgh, PA 15224, USA. Myriam.Barragan@bcm.edu.
authors.forename: Myriam
authors.initials: M
authors.lastname: Barragan
authors.affiliation: Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA. goodml3@upmc.edu.|Department of Pediatrics, School of Medicine, University of Pittsburgh Pittsburgh, PA 15224, USA. goodml3@upmc.edu.|Division of Newborn Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA. goodml3@upmc.edu.
authors.forename: Misty
authors.initials: M
authors.lastname: Good
authors.affiliation: Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA. jay.kolls@chp.edu.|Department of Pediatrics, School of Medicine, University of Pittsburgh Pittsburgh, PA 15224, USA. jay.kolls@chp.edu.
authors.forename: Jay K
authors.initials: JK
authors.lastname: Kolls
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002117:Calcitriol / Q000276:immunology / Q000378:metabolism* / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D019587:Dietary Supplements; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000819:agonists / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D018167:Receptors, Calcitriol; C579457:VDR protein, human; D002117:Calcitriol
keywords: cytokines; dendritic cells; inflammation; innate and adaptive immunity; interleukins; vitamin D; vitamin D receptor