title: Herpes Viruses Increase the Risk of Alzheimer's Disease: A Meta-Analysis.
abstract: The role of infectious agents in the development of AD has long been debated, in particular, the herpesviridae family. We therefore conducted a meta-analysis to quantitatively assess all published data to establish whether there is an association. We identified studies that looked for the presence of viral DNA in the brain and/or antibody seropositivity in people with AD from four electronic databases. 35 studies met our inclusion criteria (AD cases = 1294; controls = 3059). There was an increased risk for AD when herpesviridae is present in the brain compared to controls [OR 1.38; 95% CI 1.14-1.66]. Sub-analysis showed that APOE ɛ4 and HSV1 together increased the risk of AD development [OR 2.71; 95% CI 1.08-6.80]. HSV1 together with the presence of the APOE ɛ4 allele increases the risk of developing AD.
authors.forename: Ariah J
authors.initials: AJ
authors.lastname: Steel
authors.forename: Guy D
authors.initials: GD
authors.lastname: Eslick
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000453:epidemiology* / Q000235:genetics / Q000821:virology*; D000914:Antibodies, Viral / Q000097:blood; D053327:Apolipoprotein E4 / Q000235:genetics; D001921:Brain / Q000821:virology; D006561:Herpes Simplex / Q000097:blood / Q000453:epidemiology*; D018259:Herpesvirus 1, Human; D006801:Humans; D012306:Risk
chemical_list: D000914:Antibodies, Viral; D053327:Apolipoprotein E4
keywords: Alzheimer’s disease; HSV1; dementia; herpes virus 1; infection; neurodegeneration