title: Quantitative assessment of the association between DNMT3B-579G>T polymorphism and cancer risk.
abstract: BACKGROUND
  DNA methyltransferase 3B (DNMT3B) has been discovered to play an important role in tumorigenesis. However, the association between DNMT3B-579G>T and the cancer risk has not been demonstrated.
  
  
  OBJECTIVE
  The aim of this study is to provide a precise quantification for the association between DNMT3B-579G>T and the cancer susceptibility.
  
  
  METHODS
  We performed a systematic literature review and assessed the methodological quality of included case-control designed studies based on Newcastle-Ottawa Scale (NOS). Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) were calculated to assess the strengths of the association.
  
  
  RESULTS
  We identified 18 studies for pooled analyses. Overall, the results demonstrated that the DNMT3B-579G>T polymorphism was significantly associated with a subtly decreased cancer risk (GT vs TT: OR = 0.78, 95%CI: 0.70-0.87, P< 0.01; GT + GG vs TT: OR = 0.81, 95%CI: 0.68-0.97, P= 0.02), especially in the Asian population and in colorectal cancer subgroup. In addition, when stratified for source of controls, the results of population-based subgroup showed the GT genotype might have a significantly decreased cancer risk, but not hospital-based subgroups.
  
  
  CONCLUSIONS
  DNMT3B-579G>T polymorphism might contribute to the susceptibility of cancers especially in the Asian population and for colorectal cancer.
authors.affiliation: Department of Surgery Medicine, Division of Thoracic Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Zongjiang
authors.initials: Z
authors.lastname: Xia
authors.affiliation: Department of Hospital Infection Management, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Fujiao
authors.initials: F
authors.lastname: Duan
authors.affiliation: Department of Medical, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Jing
authors.affiliation: Department of Hospital Infection Management, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Hepatobiliary and Pancreatic Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.
authors.forename: Changfu
authors.initials: C
authors.lastname: Nie
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Song
mesh_terms: D044466:Asian People / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D000097584:DNA Methyltransferase 3B
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases; D000097584:DNA Methyltransferase 3B
keywords: DNMT3B; cancer; polymorphism; quantitative assessment