title: What are the best predictors for successful GnRH antagonist protocol in in vitro fertilization (IVF) treatment?
abstract: OBJECTIVE
  To determine factors that affect the success rate of GnRH antagonist protocol in in vitro fertilization (IVF) treatment.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Patients who underwent IVF cycle with their first GnRH antagonist protocol.
  
  
  METHODS
  Antagonist protocol during IVF treatment. The main outcome measurements were; Number of retrieved oocytes, embryo quality and pregnancy rate.
  
  
  RESULTS
  Gravidity was negatively correlated with number of eggs (p = 0.017), while total follicle number ≥15 (p = 0.044) and E(2) on day of human chorionic gonadotropin (HCG) (p = 0.000) had a positive correlation with number of eggs. Maximum follicle size at HCG administration showed a trend toward an inverse correlation (p = 0.053). Addition of LH to drug stimulation was negatively correlated with number of eggs in comparison to rFSH only (p = 0.013 and 0.0000, respectively). Age and number of frozen eggs were negatively correlated with successful pregnancy (p = 0.025 and 0.004, respectively), while embryo quality, gravidity and number of embryos were positive (p = 0.011 and 0.014, respectively).
  
  
  CONCLUSIONS
  Controlled parameters like timing of antagonist start, duration of antagonist and the optimal leading follicle diameter for HCG triggering had no effect on treatment outcomes.
authors.affiliation: a IVF Unit, Department of Obstetrics and Gynecology , Meir Medical Center , Kfar Saba , Israel , affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel.
authors.forename: Nivin
authors.initials: N
authors.lastname: Samara
authors.affiliation: a IVF Unit, Department of Obstetrics and Gynecology , Meir Medical Center , Kfar Saba , Israel , affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel.
authors.forename: Daniel
authors.initials: D
authors.lastname: Reis
authors.affiliation: a IVF Unit, Department of Obstetrics and Gynecology , Meir Medical Center , Kfar Saba , Israel , affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel.
authors.forename: Netanella
authors.initials: N
authors.lastname: Danielli Miller
authors.affiliation: a IVF Unit, Department of Obstetrics and Gynecology , Meir Medical Center , Kfar Saba , Israel , affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel.
authors.forename: Yehudith
authors.initials: Y
authors.lastname: Ghetler
authors.affiliation: a IVF Unit, Department of Obstetrics and Gynecology , Meir Medical Center , Kfar Saba , Israel , affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel.
authors.forename: Arie
authors.initials: A
authors.lastname: Berkovitz
authors.affiliation: a IVF Unit, Department of Obstetrics and Gynecology , Meir Medical Center , Kfar Saba , Israel , affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel.
authors.forename: Moses
authors.initials: M
authors.lastname: Miller
authors.affiliation: a IVF Unit, Department of Obstetrics and Gynecology , Meir Medical Center , Kfar Saba , Israel , affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel.
authors.forename: Ofer
authors.initials: O
authors.lastname: Gonen
authors.affiliation: a IVF Unit, Department of Obstetrics and Gynecology , Meir Medical Center , Kfar Saba , Israel , affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel.
authors.forename: Adrian
authors.initials: A
authors.lastname: Shulman
authors.affiliation: a IVF Unit, Department of Obstetrics and Gynecology , Meir Medical Center , Kfar Saba , Israel , affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv , Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Wiser
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002985:Clinical Protocols; D015331:Cohort Studies; D003661:Decision Support Techniques; D004624:Embryo Transfer; D004622:Embryo, Mammalian; D004958:Estradiol / Q000097:blood*; D005260:Female; D005299:Fertility Agents / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D016014:Linear Models; D007986:Luteinizing Hormone / Q000627:therapeutic use; D008596:Menotropins / Q000627:therapeutic use; D054315:Oocyte Retrieval; D006080:Ovarian Follicle / Q000000981:diagnostic imaging*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D006063:Chorionic Gonadotropin; D005299:Fertility Agents; D006727:Hormone Antagonists; D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Embryo quality; GnRH antagonist; IVF; pregnancy rate