title: Taurine Regulates Mitochondrial Function During 7,12-Dimethyl Benz[a]anthracene Induced Experimental Mammary Carcinogenesis.
abstract: OBJECTIVE
  The present study was undertaken to determine the modulatory effect of taurine on the liver mitochondrial enzyme system with reference to mitochondrial lipid peroxidation (LPO), antioxidants, major tricarboxylic acid cycle enzymes, and electron transport chain enzymes during 7,12-dimethyl benz[a]anthracene (DMBA) induced breast cancer in Sprague-Dawley rats.
  
  
  METHODS
  Animals in which breast cancer had been induced by using DMBA (25 mg/kg body weight) showed an increase in mitochondrial LPO together with decreases in enzymic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST)), non-enzymic antioxidants (reduced glutathione (GSH), vitamin C, and vitamin E), in citric acid cycle enzymes (isocitrate dehydrogenase (ICDH), alpha ketoglutarate dehydrogenase (alpha KDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH)), and in electron transport chain (ETC) complexes.
  
  
  RESULTS
  Taurine (100 mg/kg body weight) treatment decreased liver mitochondrial LPO and augmented the activities/levels of enzymic, and non-enzymic antioxidants, tricarboxylic acid cycle enzymes and ETC complexes.
  
  
  CONCLUSIONS
  The results of our present study demonstrated the chemotherapeutic efficacy of taurine treatment for DMBA-induced breast carcinomas.
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Manickam Kalappan
authors.initials: MK
authors.lastname: Vanitha
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Kalpana Deepa
authors.initials: KD
authors.lastname: Priya
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Kuppusamy
authors.initials: K
authors.lastname: Baskaran
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Kuppusamy
authors.initials: K
authors.lastname: Periyasamy
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Dhravidamani
authors.initials: D
authors.lastname: Saravanan
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Ramachandran
authors.initials: R
authors.lastname: Venkateswari
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Balasundaram Revathi
authors.initials: BR
authors.lastname: Mani
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Aruldass
authors.initials: A
authors.lastname: Ilakkia
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Sundaramoorthy
authors.initials: S
authors.lastname: Selvaraj
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Rajendran
authors.initials: R
authors.lastname: Menaka
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Mahendran
authors.initials: M
authors.lastname: Geetha
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Nadarajah
authors.initials: N
authors.lastname: Rashanthy
authors.affiliation: Department of Biomedical Sciences, College of Health Sciences, Arsi University, Asella, Ethiopia.
authors.forename: Pandi
authors.initials: P
authors.lastname: Anandakumar
authors.affiliation: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Dhanapal
authors.initials: D
authors.lastname: Sakthisekaran
keywords: breast cancer; electron transport chain complexes; mitochondrial antioxidant; mitochondrial lipid peroxidation; taurine; tricarboxylic acid cycle enzymes