title: A Nutritional Formulation for Cognitive Performance in Mild Cognitive Impairment: A Placebo-Controlled Trial with an Open-Label Extension.
abstract: Thirty-four individuals with mild cognitive impairment were randomized for 6 months to a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or indistinguishable placebo, followed by a 6-month open-label extension in which all individuals received NF. The NF cohort improved in the Dementia Rating Scale (DRS; effect size >0.7) and maintained baseline performance in CLOX-1. The placebo cohort did not improve in DRS and declined in CLOX-1, but during the open-label extension improved in DRS and ceased declining in CLOX-1. These findings extend prior studies of NF efficacy for individuals without cognitive impairment and with Alzheimer's disease.
authors.affiliation: Framingham State University, Framingham, MA, USA.
authors.forename: Ruth
authors.initials: R
authors.lastname: Remington
authors.affiliation: Knox College, Galesburg, IL, USA.
authors.forename: Jevin J
authors.initials: JJ
authors.lastname: Lortie
authors.affiliation: Knox College, Galesburg, IL, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Hoffmann
authors.affiliation: Loyola University Maryland, Baltimore, MD, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Page
authors.affiliation: Loyola University Maryland, Baltimore, MD, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Morrell
authors.affiliation: University of Massachusetts Lowell, Lowell, MA, USA.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Shea
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000178:diet therapy*; D015331:Cohort Studies; D019587:Dietary Supplements; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
keywords: Aging; Alzheimer’s disease; cognitive performance; dementia; mild cognitive impairment; nutraceutical