title: Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2.
abstract: Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc.
authors.affiliation: Department of Radiation Oncology (MAASTRO); Maastricht University Medical Centre ; Maastricht, The Netherlands.
authors.forename: Nicolle H
authors.initials: NH
authors.lastname: Rekers
authors.affiliation: Department of Radiation Oncology (MAASTRO); Maastricht University Medical Centre ; Maastricht, The Netherlands.
authors.forename: Catharina Ml
authors.initials: CM
authors.lastname: Zegers
authors.affiliation: Department of Internal Medicine GROW; School for Oncology and Developmental Biology; Maastricht University Medical Centre ; Maastricht, The Netherlands.
authors.forename: Wilfred Tv
authors.initials: WT
authors.lastname: Germeraad
authors.affiliation: Department of Radiation Oncology (MAASTRO); Maastricht University Medical Centre ; Maastricht, The Netherlands.
authors.forename: Ludwig
authors.initials: L
authors.lastname: Dubois
authors.affiliation: Department of Radiation Oncology (MAASTRO); Maastricht University Medical Centre ; Maastricht, The Netherlands.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lambin
keywords: ED-B; cytotoxic T cells; immune response; immunotherapy