title: The ensemble of genetic factors and angiogenic signals via VEGF receptors in lung cancer progression.
abstract: Lung cancer is the major cause of cancer-related mortality worldwide owing to its late-stage detection and aggressive behavior. Epidemiologically, several genetic and epigenetic factors contribute to the development of lung cancer. Angiogenesis, a critical process in tumor progression has become an important target for anti-cancer therapy particularly in lung cancer. Besides commercially available angiogenic inhibitors, numerous anti-angiogenic therapies have been developed to limit tumor growth, although, most of them have not proved beneficial in terms of long-term survival. Despite, logical advances in treatment strategies, NSCLC still remains a major health concern due to poor prognosis of the diseases state. This calls for a comprehensive analysis of signaling processes governing tumor angiogenesis and treatment options available thereof for development of a sustainable strategy to control cancer. In this review, several aspects of lung cancer have been discussed starting from its pathological characterization to the development of modern therapeutics.
authors.forename: Qazi
authors.initials: Q
authors.lastname: Danish
authors.forename: Taseem A
authors.initials: TA
authors.lastname: Mokhdomi
authors.forename: Shoiab
authors.initials: S
authors.lastname: Bukhari
authors.forename: Raies
authors.initials: R
authors.lastname: Ahmad
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D040262:Receptors, Vascular Endothelial Growth Factor / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D040262:Receptors, Vascular Endothelial Growth Factor
keywords: Lung cancer; VEGF receptors; angiogenesis