title: Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis.
abstract: A section of gastric cancers presents nuclear β-catenin accumulation correlated with H. pylori infection. H. pylori stimulate Wnt/β-catenin pathway by activating oncogenic c-Met and epidermal growth factor receptor (EGFR), or by inhibiting tumor suppressor Runx3 and Trefoil factor 1 (TFF1). H. pylori also trigger Wnt/β-catenin pathway by recruiting macrophages. Moreover, Wnt/β-catenin pathway is found involved in H. pylori-induced gastric cancer stem cell generation. Recently, by using gastroids, researchers have further revealed that H. pylori induce gastric epithelial cell proliferation through β-catenin. These findings indicate that Wnt/β-catenin is an oncogenic pathway activated by H. pylori. Therefore, this pathway is a potential therapy target for H. pylori-related gastric cancer.
authors.affiliation: Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
authors.forename: Na
authors.initials: N
authors.lastname: Xin
authors.affiliation: Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
authors.forename: Chenghai
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000382:microbiology / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins; D051176:beta Catenin
keywords: Helicobacter pylori; Wnt; gastric cancer; β-catenin