title: [The impact of chromatin modification on the development of chronic complications in patients with diabetes].
abstract: Diabetes is a chronic, metabolic disease. Over 347 million people worldwide have diabetes. Chronic complications (retinopathy, nephropathy or neuropathy) are the major dangerous outcome of this disease. Recent studies indicate a significant role of epigenetic regulation in the development of chronic complications in patients with diabetes. Hyperglycemia could cause abnormal regulation of the activity of enzymes participating in the post-translational histone modifications (PTHMs) and initiation of changes in patterns of DNA methylation. It leads to modification of chromatin structure. These epigenetic abnormalities result in changes in the expression of genes involved in development of chronic inflammation, such as NF-KAPPAB (nuclear factor kappaB gene), TNFα (tumor necrosis factor a gene), IL6 (interleukin 6 gene) or MCP1 (monocyte chemoattractant protein 1 gene). It enhances endothelial cell dysfunction, which plays an important role in development of chronic, diabetic complications. In addition, caused by hyperglycemia epigenetic modifications changes in structure of chromatin explains "metabolic memory", a phenomenon of presence of pathological pathways related to the prolonged hyperglycemia in the past, despite maintaining good metabolic control later on.
authors.affiliation: Pracownia Metabolizmu Lipidów, Katedra Chemii i Biochemii Klinicznej Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wegner
authors.affiliation: Zakład Biochemii Klinicznej i Medycyny Laboratoryjnej, Katedra Chemii i Biochemii Klinicznej Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu.
authors.forename: Maria
authors.initials: M
authors.lastname: Pioruńska-Stolzmann
authors.affiliation: Katedra i Zakład Biochemii i Biologii Molekularnej Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu.
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D002843:Chromatin / Q000378:metabolism*; D048909:Diabetes Complications / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism*; D044127:Epigenesis, Genetic / Q000502:physiology*; D006801:Humans
chemical_list: D002843:Chromatin