title: Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla.
abstract: Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F-H (1, 3, 4), 17-epi-rauvotetraphylline F (2) and 21-epi-rauvotetraphylline H (5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.|Department of Chemical Engineering, Yibin University, Yibin, 644000, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Zhou
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Hai
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China. f.wang@mail.biobiopha.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
keywords: Monoterpenoid indole alkaloid; Rauvolfia tetraphylla; Rauvotetraphylline