title: B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.
abstract: The protective role of B cells and humoral immune responses in tuberculosis infection has been regarded as inferior to cellular immunity directed to the intracellular pathogen Mycobacterium tuberculosis. However, B-cell-mediated immune responses in tuberculosis have recently been revisited in the context of B-cell physiology and antigen presentation. We discuss in this review the diverse functions of B cells in tuberculosis, with a focus on their biological and clinical relevance to progression of active disease. We also present the peptide microarray platform as a promising strategy to discover unknown antigenic targets of M. tuberculosis that could contribute to the better understanding of epitope focus of the humoral immune system against M. tuberculosis.
authors.affiliation: Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet.
authors.forename: Martin
authors.initials: M
authors.lastname: Rao
authors.affiliation: Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Davide
authors.initials: D
authors.lastname: Valentini
authors.affiliation: Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet.
authors.forename: Thomas
authors.initials: T
authors.lastname: Poiret
authors.affiliation: Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet.
authors.forename: Ernest
authors.initials: E
authors.lastname: Dodoo
authors.affiliation: Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet.
authors.forename: Shreemanta
authors.initials: S
authors.lastname: Parida
authors.affiliation: Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre at University College Hospitals NHS Foundation Trust, United Kingdom.
authors.forename: Alimuddin
authors.initials: A
authors.lastname: Zumla
authors.affiliation: Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Susanna
authors.initials: S
authors.lastname: Brighenti
authors.affiliation: Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Markus
authors.initials: M
authors.lastname: Maeurer
mesh_terms: D000907:Antibodies, Bacterial / Q000627:therapeutic use; D000942:Antigens, Bacterial / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000502:physiology*; D016207:Cytokines; D018985:Epitopes, B-Lymphocyte; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D019151:Peptide Library; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D016207:Cytokines; D018985:Epitopes, B-Lymphocyte; D019151:Peptide Library
keywords: B cells; antibodies; cytokines; host-directed therapy; tuberculosis