title: Short-Term Postnatal Renal Function in Twin Anemia-Polycythemia Sequence.
abstract: OBJECTIVE
  To evaluate the short-term renal function in neonates with twin anemia-polycythemia sequence (TAPS).
  
  
  METHODS
  All consecutive monochorionic twins with TAPS with double survivors admitted to three European centers were included in this retrospective study. Each twin pair was matched for gestational age at birth with a control twin pair unaffected by TAPS or twin-twin transfusion syndrome. Creatinine and urea levels in the first week after birth were recorded. Short-term postnatal renal dysfunction was defined as creatinine >100 μmol/l during the first week after birth.
  
  
  RESULTS
  A total of 52 TAPS twin pairs and 52 control twin pairs with a median gestational age of 31 weeks at birth were included in the study. In the TAPS group, donors had higher mean creatinine levels compared to recipients, 85 versus 71 μmol/l, respectively (p = 0.001). Short-term renal dysfunction was detected in 26.0% (13/50) of the donors versus 6.3% (3/48) of the recipients (p = 0.022). In the control group, no inter-twin differences in creatinine levels were found.
  
  
  CONCLUSIONS
  Donor twins with TAPS have higher creatinine levels than recipient twins, suggesting that chronic inter-twin transfusion in TAPS may also cause short-term renal dysfunction. Long-term renal consequences in TAPS donors require further investigation.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Lianne
authors.initials: L
authors.lastname: Verbeek
authors.forename: Femke
authors.initials: F
authors.lastname: Slaghekke
authors.forename: Romain
authors.initials: R
authors.lastname: Favre
authors.forename: Marine
authors.initials: M
authors.lastname: Vieujoz
authors.forename: Francesco
authors.initials: F
authors.lastname: Cavigioli
authors.forename: Gianluca
authors.initials: G
authors.lastname: Lista
authors.forename: Dick
authors.initials: D
authors.lastname: Oepkes
authors.forename: Enrico
authors.initials: E
authors.lastname: Lopriore
mesh_terms: D003401:Creatine / Q000097:blood; D005260:Female; D005330:Fetofetal Transfusion / Q000097:blood / Q000150:complications*; D005865:Gestational Age; D006801:Humans; D011086:Polycythemia / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D047928:Premature Birth; D017701:Reticulocyte Count; D012189:Retrospective Studies; D014508:Urea / Q000097:blood
chemical_list: D014508:Urea; D003401:Creatine