title: [Association of pleomorphic adenoma gene 1 polymorphism and benign parotid tumor in Chinese Han population in Hainan Province].
abstract: OBJECTIVE
  To investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1 (PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province.
  
  
  METHODS
  Sixty-five patients with benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by PCR and sequencing.
  
  
  RESULTS
  Of the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were 33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05). The allele frequency of C/T was 70%/30% in patients with benign parotid tumor, significantly different from that in the control group (80.6%/19.4%, P<0.05).
  
  
  CONCLUSIONS
  Rs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.
authors.affiliation: Department of Stomatology, Nongken Sanya Hospital, Sanya 572000, China.E-mail: 511684568@qq.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Huang
authors.forename: Xunding
authors.initials: X
authors.lastname: Qiu
authors.forename: Minglei
authors.initials: M
authors.lastname: Sun
authors.forename: Shengteng
authors.initials: S
authors.lastname: He
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D010307:Parotid Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D018797:Cell Cycle Proteins; C106464:PLAGL1 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins