title: High Salt Intake Is Independently Associated With Hypertensive Target Organ Damage.
abstract: The authors tested the hypothesis that high salt intake is associated with hypertensive target organ damage (TOD) independent of blood pressure (BP), and oxidative stress is a modifying factor of this association. A total of 369 community-dwelling Japanese adults (mean age, 67.5 years; 56.6% women) were examined in this observational study. At the patients' annual health check-ups, urinary salt excretion (U-SALT), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and albumin-creatinine ratio (UACR) were measured from first morning urine. U-SALT (β=0.14, P=.016) and 8-OHdG (β=0.13, P=.018) were both independently associated with logUACR. U-SALT was associated with TOD independent of BP level, and oxidative stress may be a modifying factor in the association between high salt intake and TOD. The elevation of 8-OHdG may be involved in the pathophysiology of TOD induced by salt intake.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Imaizumi
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Eguchi
authors.affiliation: Munakata Ohshima Clinic, Munakata, Fukuoka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Murakami
authors.affiliation: Division of Clinical Research Institute, National Kyushu Medical Center, Fukuoka, Japan.
authors.forename: Kimika
authors.initials: K
authors.lastname: Arakawa
authors.affiliation: Steel Memorial Yawata Hospital, Kitakyushu, Fukuoka, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Tsuchihashi
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Kario
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000652:urine; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology* / Q000652:urine; D007564:Japan / Q000453:epidemiology; D008297:Male; D009017:Morbidity / Q000639:trends; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012965:Sodium Chloride / Q000652:urine*; D017673:Sodium Chloride, Dietary / Q000009:adverse effects* / Q000493:pharmacokinetics; D015996:Survival Rate / Q000639:trends
chemical_list: D015415:Biomarkers; D017673:Sodium Chloride, Dietary; D012965:Sodium Chloride