title: Innate immune cells in the pathogenesis of primary systemic vasculitis.
abstract: Innate immune system forms the first line of defense against foreign substances. Neutrophils, eosinophils, erythrocytes, platelets, monocytes, macrophages, dendritic cells, γδ T cells, natural killer and natural killer T cells comprise the innate immune system. Genetic polymorphisms influencing the activation of innate immune cells predispose to development of vasculitis and influence its severity. Abnormally activated innate immune cells cross-talk with other cells of the innate immune system, present antigens more efficiently and activate T and B lymphocytes and cause tissue destruction via cell-mediated cytotoxicity and release of pro-inflammatory cytokines. These secreted cytokines further recruit other cells to the sites of vascular injury. They are involved in both the initiation as well as the perpetuation of vasculitis. Evidences suggest reversal of aberrant activation of immune cells in response to therapy. Understanding the role of innate immune cells in vasculitis helps understand the potential of therapeutic modulation of their activation to treat vasculitis.
authors.affiliation: Department of Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareily Road, Lucknow, Uttar Pradesh, 226 014, India. durgapmisra@gmail.com.
authors.forename: Durga Prasanna
authors.identifier: http://orcid.org/0000-0002-5035-7396
authors.initials: DP
authors.lastname: Misra
authors.affiliation: Department of Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareily Road, Lucknow, Uttar Pradesh, 226 014, India. vikasagr@yahoo.com.
authors.forename: Vikas
authors.initials: V
authors.lastname: Agarwal
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000276:immunology* / Q000473:pathology; D002450:Cell Communication; D006801:Humans; D007107:Immune System / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology; D009000:Monocytes / Q000276:immunology* / Q000473:pathology; D022423:Myeloid Cells / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D015398:Signal Transduction; D056647:Systemic Vasculitis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D018836:Inflammation Mediators
keywords: Innate immunity; Monocytes; Myeloid cells; Pathogenesis; Platelets; Vasculitis