title: Health-Related Quality of Life in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment and its Relation to Activities of Daily Living.
abstract: BACKGROUND
  Health related quality of life (HRQOL) is an important issue in the context of dementia care.
  
  
  OBJECTIVE
  The purpose of this study was to investigate HRQOL in patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) and its relation to Activity of Daily Living (ADL).
  
  
  METHODS
  In this cross sectional study, four experimental groups (each n = 98), controls, SCD, naMCI and aMCI, were compared. For data collection, neuropsychological methods (NTBV) and psychological questionnaires (SF-36 and B-ADL) were used. Multivariate analysis of variance was calculated to detect differences in HRQOL between groups. Correlations between HRQOL and ADL were explored.
  
  
  RESULTS
  The dimensions of HRQOL showed mainly consistent differences between the control and the SCD group and MCI subgroups. In almost every dimension of HRQOL, the control group scored higher than subjects with SCD, naMCI, or aMCI. The controls showed low to moderate negative correlations between HQROL and B-ADL in some dimensions of the HRQOL. In the SCD group, low negative correlations with ADL were observed in some HRQOL scales. Low to moderate correlations were found between each scale of the SF-36 and the B-ADL in both MCI subtypes. We found gender differences in HRQOL.
  
  
  CONCLUSIONS
  In conclusion, we could demonstrate that patients with SCD report reduced quality of life. This knowledge is important to get a better understanding of the individuals with SCD and may pave the way for the development of early intervention.
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria.
authors.forename: Gisela
authors.initials: G
authors.lastname: Pusswald
authors.affiliation: Faculty of Psychology, University of Vienna, Vienna, Austria.
authors.forename: Elisa
authors.initials: E
authors.lastname: Tropper
authors.affiliation: Faculty of Psychology, University of Vienna, Vienna, Austria.
authors.forename: Ilse
authors.initials: I
authors.lastname: Kryspin-Exner
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria.
authors.forename: Doris
authors.initials: D
authors.lastname: Moser
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Klug
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria.
authors.forename: Eduard
authors.initials: E
authors.lastname: Auff
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Dal-Bianco
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria.
authors.forename: Johann
authors.initials: J
authors.lastname: Lehrner
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000368:Aged; D000647:Amnesia / Q000523:psychology; D000704:Analysis of Variance; D060825:Cognitive Dysfunction / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010465:Perception; D011446:Prospective Studies; D011581:Psychological Tests; D011788:Quality of Life / Q000523:psychology*; D012737:Sex Factors
keywords: Activities of daily living; health related quality of life; mild cognitive impairment; subjective cognitive decline