title: Synthesis, characterization, crystal structure determination and biological screening of novel N-1 and C5 alkyl substituted scaffolds of pyrimidine.
abstract: The novel N-1 and C5 alkyl substituted derivatives of pyrimidine were synthesized by using tetrabutyl ammonium bromide (TBAB) as phase transfer catalyst at 20-25 °C with excellent productivity (85-95%). The new compounds were evaluated for their antibacterial activities by screening them against Gram-positive and Gram-negative bacterial strain: Staphylococcus aureus ATCC 6538P, Salmonella abony NCTC 6017: Escherichia coli ATCC 8739, Staphylococcus epidermidis ATCC 12228. Among all compounds evaluated the molecule 2c and (2g-j) exhibit the most pronounced antibacterial activity against E. coli, S. aureus and S. abony with MICs value 25 μg/mL.
authors.affiliation: Department of Chemistry, Institute of Science, Civil Lines, Nagpur 440001, MS, India. Electronic address: naziyaaliparvez@gmail.com.
authors.forename: Naziyanaz B
authors.initials: NB
authors.lastname: Pathan
authors.affiliation: Prince Sultan Medical Military City, Riyadh 11159, Saudi Arabia.
authors.forename: Ali
authors.initials: A
authors.lastname: Parvez
authors.affiliation: Department of Pharmacgnosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
authors.forename: Ammar
authors.initials: A
authors.lastname: Bader
authors.affiliation: Department of Pharmacgnosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
authors.forename: Usama
authors.initials: U
authors.lastname: Shaheen
authors.affiliation: Laboratoire Chimie des Matériaux, Faculté Sciences, Université Mohammed Mohammed Premier, Oujda 6000, Morocco.
authors.forename: Taibi B
authors.initials: TB
authors.lastname: Hadda
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D012475:Salmonella / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines; C030986:pyrimidine
keywords: Alkylpyrimidines; Antibacterial activity; Characterization; Crystal structure