title: Middle East respiratory syndrome: current status and future prospects for vaccine development.
abstract: The outbreaks of Middle East respiratory syndrome (MERS) previously in Middle East and recently in South Korea have raised serious concerns worldwide, reinforcing the importance of developing effective and safe vaccines against MERS-coronavirus (MERS-CoV). A number of vaccine candidates have been developed on the basis of viral vectors, recombinant proteins, DNAs, nanoparticles, and recombinant MERS-CoV, and some of them have shown efficacy in laboratory animals. However, the paucity of financial support has made it difficult to transfer effective candidates from the preclinical stage to clinical trials. Here, we summarize currently available MERS vaccine candidates and illustrate strategies for future development, with the aim of provoking government agencies and Big Pharma to invest more funds for developing efficacious and safe MERS vaccines.
authors.affiliation: a 1 Lindsley F. Kimball Research Institute, New York Blood Center , NY, USA +1 212 570 3459 ; ldu@nybloodcenter.org.
authors.forename: Lanying
authors.initials: L
authors.lastname: Du
authors.affiliation: a 1 Lindsley F. Kimball Research Institute, New York Blood Center , NY, USA +1 212 570 3459 ; ldu@nybloodcenter.org.|b 2 Fudan University, Shanghai Medical College and Institute of Medical Microbiology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health , Shanghai, China +1 212 570 3058 ; sjiang@nybloodcenter.org.
authors.forename: Shibo
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000818:Animals; D018352:Coronavirus Infections / Q000517:prevention & control* / Q000821:virology; D004195:Disease Models, Animal; D005822:Genetic Vectors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D065207:Middle East Respiratory Syndrome Coronavirus / Q000276:immunology*; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology*
chemical_list: D011994:Recombinant Proteins; D014765:Viral Vaccines
keywords: Animal models; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; receptor-binding domain; spike protein; vaccines