title: Searching for "monogenic diabetes" in dogs using a candidate gene approach.
abstract: BACKGROUND
  Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and similarities between canine and human diabetes phenotypes suggest that the same genes might be associated with disease susceptibility in both species. Between 1-5% of human diabetes cases result from mutations in a single gene, including maturity onset diabetes of the adult (MODY) and neonatal diabetes mellitus (NDM). It is not clear whether monogenic forms of diabetes exist within some dog breeds. Identification of forms of canine monogenic diabetes could help to resolve the heterogeneity of the condition and lead to development of breed-specific genetic tests for diabetes susceptibility.
  
  
  RESULTS
  Seventeen dog breeds were screened for single nucleotide polymorphisms (SNPs) in eighteen genes that have been associated with human MODY/NDM. Six SNP associations were found from five genes, with one gene (ZFP57) being associated in two different breeds.
  
  
  CONCLUSIONS
  Some of the genes that have been associated with susceptibility to MODY and NDM in humans appear to also be associated with canine diabetes, although the limited number of associations identified in this study indicates canine diabetes is a heterogeneous condition and is most likely to be a polygenic trait in most dog breeds.
authors.affiliation: Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT UK.
authors.forename: Andrea D
authors.initials: AD
authors.lastname: Short
authors.affiliation: Department of Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA UK.
authors.forename: Angela
authors.initials: A
authors.lastname: Holder
authors.affiliation: Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Rothwell
authors.affiliation: Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Massey
authors.affiliation: Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Scholey
authors.affiliation: Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT UK.
authors.forename: Lorna J
authors.initials: LJ
authors.lastname: Kennedy
authors.affiliation: Department of Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA UK.
authors.forename: Brian
authors.initials: B
authors.lastname: Catchpole
authors.affiliation: Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT UK.
authors.forename: William Er
authors.initials: WE
authors.lastname: Ollier
keywords: Candidate genes; Diabetes mellitus; Dog breeds