title: Anakinra induces complete remission of nephrotic syndrome in a patient with familial mediterranean fever and amyloidosis.
abstract: Renal amyloidosis is one of the most severe complications of familial Mediterranean fever (FMF). Colchicine has reduced the incidence of this complication, which now only appears in untreated, under-treated and resistant patients, but it is usually ineffective in patients with advanced amyloidosis. Here we report a patient with FMF and biopsy-proven amyloidosis who presented with nephrotic syndrome despite colchicine treatment. Anakinra (an interleukin-1β inhibitor) was started and a dramatic complete remission of nephrotic syndrome was observed in the following months. Anakinra can be an effective treatment for FMF patients with severe secondary amyloidosis.
authors.affiliation: Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, España. Electronic address: sevillano.am@gmail.com.
authors.forename: Ángel M
authors.initials: ÁM
authors.lastname: Sevillano
authors.affiliation: Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hernandez
authors.affiliation: Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: Esther
authors.initials: E
authors.lastname: Gonzalez
authors.affiliation: Servicio de Reumatología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: Isabel
authors.initials: I
authors.lastname: Mateo
authors.affiliation: Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gutierrez
authors.affiliation: Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: Enrique
authors.initials: E
authors.lastname: Morales
authors.affiliation: Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, España; Departamento de Medicina, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, España.
authors.forename: Manuel
authors.initials: M
authors.lastname: Praga
mesh_terms: D000686:Amyloidosis / Q000188:drug therapy* / Q000209:etiology; D003078:Colchicine; D010505:Familial Mediterranean Fever / Q000150:complications*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000209:etiology
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D003078:Colchicine
keywords: Amiloidosis; Amyloidosis; Anakinra; Colchicina; Colchicine; Familial Mediterranean fever; Fiebre mediterránea familar