title: Medial Demons Registration Localizes The Degree of Genetic Influence Over Subcortical Shape Variability: An N= 1480 Meta-Analysis.
abstract: We present a multi-cohort shape heritability study, extending the fast spherical demons registration to subcortical shapes via medial modeling. A multi-channel demons registration based on vector spherical harmonics is applied to medial and curvature features, while controlling for metric distortion. We registered and compared seven subcortical structures of 1480 twins and siblings from the Queensland Twin Imaging Study and Human Connectome Project:Thalamus, Caudate, Putamen, Pallidum, Hippocampus, Amygdala,andNucleus Accumbens. Radial distance and tensor-based morphometry (TBM) features were found to be highly heritable throughout the entire basal ganglia and limbic system. Surface maps reveal subtle variation in heritability across functionally distinct parts of each structure. Medial Demons reveals more significantly heritable regions than two previously described surface registration methods. This approach may help to prioritize features and measures for genome-wide association studies.
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Rey, CA.
authors.forename: Boris A
authors.initials: BA
authors.lastname: Gutman
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Rey, CA.
authors.forename: Neda
authors.initials: N
authors.lastname: Jahanshad
authors.affiliation: University of California, Los Angeles, Los Angeles, CA.
authors.forename: Christopher R K
authors.initials: CR
authors.lastname: Ching
authors.affiliation: Department of Computer Science and Engineering, Arizona State University, Tempe, AZ.
authors.forename: Yalin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD.
authors.forename: Peter V
authors.initials: PV
authors.lastname: Kochunov
authors.affiliation: Department of Statistics, University of Warwick, Coventry, UK.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Nichols
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Rey, CA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
keywords: heritability; medial curves; meta-analysis; shape registration; spherical demons