title: Suppression of atopic dermatitis in mice model by reducing inflammation utilizing phosphatidylserine-coated biodegradable microparticles.
abstract: Controlling inflammatory response is important to avoid chronic inflammation in many diseases including atopic dermatitis (AD). In this research, we tried using a phosphatidylserine (PS)-coated microparticles in the AD mouse model for achieving the modulation of the macrophage phenotype to an anti-inflammatory state. Here, we prepared poly (D,L-lactic acid) microparticle coated with PS on the outside shell. We confirmed the cellular uptake of the PS-coated microparticle, which leads to the significant downregulation of the inflammatory cytokine production. In the mouse model of AD, the PS-coated microparticle was injected subcutaneously for a period of 12 days. The mice showed significant reduction in the development of AD symptoms comparing with the mice treated with the PC-coated microparticle.
authors.affiliation: a Faculty of Engineering, Department of Applied Chemistry , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.
authors.forename: Purnima
authors.initials: P
authors.lastname: Kumar
authors.affiliation: b Graduate School of Systems Life Sciences , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.
authors.forename: Md Zahangir
authors.initials: MZ
authors.lastname: Hosain
authors.affiliation: c Department of Biomedical Engineering , National Cerebral and Cardiovascular Center Research Institute , 5-7-1 Fujishirodai, Suita, Osaka 565-8565 , Japan.
authors.forename: Jeong-Hun
authors.initials: JH
authors.lastname: Kang
authors.affiliation: b Graduate School of Systems Life Sciences , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Takeo
authors.affiliation: a Faculty of Engineering, Department of Applied Chemistry , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.|b Graduate School of Systems Life Sciences , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.|d Center for Future Chemistry , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kishimura
authors.affiliation: a Faculty of Engineering, Department of Applied Chemistry , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.|b Graduate School of Systems Life Sciences , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.|d Center for Future Chemistry , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.affiliation: a Faculty of Engineering, Department of Applied Chemistry , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.|b Graduate School of Systems Life Sciences , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.|d Center for Future Chemistry , Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395 , Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002417:Cattle; D002478:Cells, Cultured; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D016503:Drug Delivery Systems / Q000379:methods*; D004527:Egg Proteins / Q000737:chemistry; D005260:Female; D007279:Injections, Subcutaneous; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008810:Mice, Inbred C57BL; D010718:Phosphatidylserines / Q000008:administration & dosage*; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D004527:Egg Proteins; D010718:Phosphatidylserines; D014409:Tumor Necrosis Factor-alpha
keywords: atopic dermatitis; microparticle; phosphatidylserine; subcutaneous injection