title: HLA-B27 antigen frequency among suspected Spondyloarthropathy patients attaining a tertiary level hospital of Bangladesh.
abstract: Human leukocyte antigen B27 (HLA-B27), a class I molecules of the major histocompatibility complex has a strong disease association with different types of spondarthropathies (SpA). The strength of this disease association varies markedly among racial and ethnic populations. The present study aimed to identify the HLA-B27 antigen frequencies among suspected SpA patients as well as healthy Bangladeshi individuals. The frequency of HLA-B27 was determined in 1500 patients and 1000 healthy subjects attending the Bangabandhu Sheikh Mujib Medical University (BSMMU). HLA-B 27 typing was done by microlymphocytotoxicity test using commercial kit. A total of 738 (49.2%) suspected SpA patients and 107 (10.7%) healthy subjects tested positive for HLA-B27 antigen with higher frequency among younger age groups (54.9%, 52.4% and 56.2% in 0-14 years, 15-24 years and 25-34 years of age respectively). The male female positivity was almost same (11.4% and 9.6%) among control group, but in patient group it was 53.0% and 41.2% respectively. The findings of this hospital based study showed a high frequency of HLA-B27 among suspected SpA patients with male preponderance which is comparable with neighboring countries.
authors.forename: A
authors.initials: A
authors.lastname: Nessa
authors.forename: S
authors.initials: S
authors.lastname: Tabassum
authors.forename: S
authors.initials: S
authors.lastname: Sultana
mesh_terms: D000293:Adolescent; D000328:Adult; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood*; D006801:Humans; D007159:Immunologic Tests; D007223:Infant; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D025242:Spondylarthropathies / Q000097:blood* / Q000503:physiopathology; D062606:Tertiary Care Centers; D055815:Young Adult
chemical_list: D015796:HLA-B27 Antigen