title: Tumor cell-derived microparticles: a new form of cancer vaccine.
abstract: For cancer vaccines, tumor antigen availability is currently not an issue due to technical advances. However, the generation of optimal immune stimulation during vaccination is challenging. We have recently demonstrated that tumor cell-derived microparticles (MP) can function as a new form of potent cancer vaccine by efficiently activating type I interferon pathway in a cGAS/STING dependent manner.
authors.affiliation: State Key Laboratory of Medical Molecular Biology & Department of Immunology; Institute of Basic Medical Sciences; Chinese Academy of Medical Sciences & Peking Union Medical College ; Beijing, China.
authors.forename: Huafeng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Medical Molecular Biology & Department of Immunology; Institute of Basic Medical Sciences; Chinese Academy of Medical Sciences & Peking Union Medical College ; Beijing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
keywords: cGAS; cancer vaccine; dendritic cells; microparticle; type I IFN