title: Acute pain: a multifaceted challenge - the role of nimesulide.
abstract: BACKGROUND
  This article summarizes the outcome from an international consensus meeting, which took place in Vienna on 4 November 2014.
  
  
  METHODS
  The aim of the meeting was to provide the state of the art on the pathophysiology and treatment of acute pain with special emphasis on nimesulide, a non-steroidal anti-inflammatory drug (NSAID) indicated for the treatment of acute pain and primary dysmenorrhea. Besides the data on the mechanisms of acute inflammatory pain and on the efficacy and safety of nimesulide in patients affected by different forms of acute pain, the clinical experience of attending experts was discussed based on selected case reports.
  
  
  RESULTS
  The members of this consensus group recognized that nimesulide is a NSAID highly effective in the treatment of several painful situations with an acute inflammatory component including primary dysmenorrhea. Although safety concerns regarding nimesulide have emerged in recent years, both robust new epidemiological data and clinical experience confirm a positive benefit/risk profile of nimesulide in the treatment of several forms of acute pain.
  
  
  CONCLUSIONS
  The members of this international consensus group concluded that nimesulide, when used appropriately, remains a particularly valuable and safe option for the treatment of several conditions characterized by the presence of acute inflammatory pain because of the rapid onset of the analgesic action, and the positive evidence-based benefit/risk profile.
authors.affiliation: a a Medical University/AKH Vienna - Dept. of Special Anaesthesia and Pain Therapy , Vienna , Austria.
authors.forename: H G
authors.initials: HG
authors.lastname: Kress
authors.affiliation: b b Emergency Trauma Hospital 'N.I. Pirogov' -Department of Trauma Surgery , Sofia , Bulgaria.
authors.forename: A
authors.initials: A
authors.lastname: Baltov
authors.affiliation: c c Medical University of Gdańsk, Clinical Emergency Department of the University Clinical Center , Gdańsk , Poland.
authors.forename: A
authors.initials: A
authors.lastname: Basiński
authors.affiliation: d d Clinical Hospital Saint Maria, Carol Davila University of Medicine, Department of Rheumatology , Bucharest , Romania.
authors.forename: F
authors.initials: F
authors.lastname: Berghea
authors.affiliation: e e RTI Health Solutions International , Barcelona , Spain.
authors.forename: J
authors.initials: J
authors.lastname: Castellsague
authors.affiliation: f f Center of Rheumatic Disease 'Dr. Ion Stoia', Carol Davila University of Medicine, Rheumatology Department , Bucharest , Romania.
authors.forename: C
authors.initials: C
authors.lastname: Codreanu
authors.affiliation: g g University Emergency Hospital, Carol Davila University of Medicine - Anesthesia and Intensive Care Department , Bucharest , Romania.
authors.forename: E
authors.initials: E
authors.lastname: Copaciu
authors.affiliation: h h 'G. d'Annunzio' University of Chieti-Pescara - Department of Medicine and Science of Aging , Chieti , Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Giamberardino
authors.affiliation: i i Masaryk University St. Ann's University Hospital - Department of Anesthesiology and Intensive Care Medicine , Brno , Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Hakl
authors.affiliation: j j Faculty of Sports Studies Masaryk University - Department of Health Support , Brno , Czech Republic.
authors.forename: L
authors.initials: L
authors.lastname: Hrazdira
authors.affiliation: k k Orthopedic Department, Children's Faculty Hospital , Bratislava , Slovak Republic.
authors.forename: M
authors.initials: M
authors.lastname: Kokavec
authors.affiliation: l l University Hospital Pilsen - Department of Anaesthesiology and Intensive Care , Plzeň , Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Lejčko
authors.affiliation: m m Masaryk University St. Anne's University Hospital - 1st Orthopaedics Department , Brno , Czech Republic.
authors.forename: L
authors.initials: L
authors.lastname: Nachtnebl
authors.affiliation: n n Research Institute of Rheumatic Diseases in Piešťany -National Institute of Rheumatic Diseases , Piešťany , Slovak Republic.
authors.forename: R
authors.initials: R
authors.lastname: Stančík
authors.affiliation: o o University Hospital Bratislava - First Department of Orthopaedics and Trauma Surgery , Bratislava , Slovak Republic.
authors.forename: A
authors.initials: A
authors.lastname: Švec
authors.affiliation: p p MÁV PolyClinic - Department of Rheumatology , Debrecen , Hungary.
authors.forename: T
authors.initials: T
authors.lastname: Tóth
authors.affiliation: q q Medical University of Sofia - Department of Pharmacology and Toxicology , Sofia , Bulgaria.
authors.forename: M V
authors.initials: MV
authors.lastname: Vlaskovska
authors.affiliation: r r Jagellonian University College of Medicine - Department of Clinical Pharmacology and Department of Pain Treatment and Palliative Care , Kraków , Poland.
authors.forename: J
authors.initials: J
authors.lastname: Woroń
mesh_terms: D059787:Acute Pain / Q000188:drug therapy*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D013449:Sulfonamides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; C012655:nimesulide
keywords: Acute pain; NSAID safety; Nimesulide