title: Deformable image registration of CT images for automatic contour propagation in radiation therapy.
abstract: Radiotherapy treatment plan may be replanned due the changes of tumors and organs at risk (OARs) during the treatment. Deformable image registration (DIR) based Computed Tomography (CT) contour propagation in the routine clinical setting is expected to reduce time needed for necessary manual tumors and OARs delineations and increase the efficiency of replanning. In this study, a DIR method was developed for CT contour propagation. Prior structure delineations were incorporated into Demons DIR, which was represented by adding an intensity matching term of the delineated tissues pairs to the energy function of Demons. The performance of our DIR was evaluated with five clinical head-and-neck and five lung cancer cases. The experimental results verified the improved accuracy of the proposed registration method compared with conventional registration and Demons DIR.
authors.affiliation: University of Science and Technology of China, Hefei, Anhui 230027, China.|Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei 230031, China.|Engineering Technology Research Center of Accurate Radiotherapy of Anhui Province, Hefei 230031, China.|School of General Education, Anhui Medical University, Hefei, Anhui 230032, China.|Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215006, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei 230031, China.|Engineering Technology Research Center of Accurate Radiotherapy of Anhui Province, Hefei 230031, China.|Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215006, China.
authors.forename: Ruifen
authors.initials: R
authors.lastname: Cao
authors.affiliation: Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei 230031, China.|Engineering Technology Research Center of Accurate Radiotherapy of Anhui Province, Hefei 230031, China.|Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215006, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Pei
authors.affiliation: Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei 230031, China.|Engineering Technology Research Center of Accurate Radiotherapy of Anhui Province, Hefei 230031, China.|Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215006, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jia
authors.affiliation: University of Science and Technology of China, Hefei, Anhui 230027, China.|Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei 230031, China.|Engineering Technology Research Center of Accurate Radiotherapy of Anhui Province, Hefei 230031, China.|Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215006, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Hu
mesh_terms: D000465:Algorithms; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted / Q000191:economics / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000191:economics / Q000379:methods*; D057188:Workflow
keywords: Computed tomography; contour propagation; deformable image registration; structure delineation