title: Rotavirus NSP6 localizes to mitochondria via  a predicted N-terminal a-helix.
abstract: Specific roles have been ascribed to each of the 12 known rotavirus proteins apart from the non-structural protein 6 (NSP6). However, NSP6 may be present at sites of viral replication within the cytoplasm. Here we report that NSP6 from diverse species of rotavirus A localizes to mitochondria via conserved sequences in a predicted N-terminal a-helix. This suggests that NSP6 may affect mitochondrial functions during rotavirus infection.
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
authors.forename: Gavan
authors.initials: G
authors.lastname: Holloway
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
authors.forename: Rebecca I
authors.initials: RI
authors.lastname: Johnson
authors.affiliation: Department of Biochemistry and Molecular Biology, The Bio21 Institute, The University of Melbourne, Victoria, Australia.
authors.forename: Yilin
authors.initials: Y
authors.lastname: Kang
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
authors.forename: Vi T
authors.initials: VT
authors.lastname: Dang
authors.affiliation: Department of Biochemistry and Molecular Biology, The Bio21 Institute, The University of Melbourne, Victoria, Australia.
authors.forename: Diana
authors.initials: D
authors.lastname: Stojanovski
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Coulson
mesh_terms: D000818:Animals; D002460:Cell Line; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D057809:HEK293 Cells; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D021381:Protein Transport; D012401:Rotavirus / Q000235:genetics / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000502:physiology*; D014779:Virus Replication
chemical_list: C434829:NSP6 protein, rotavirus group A; D017361:Viral Nonstructural Proteins