title: Incidental risk for diabetes according to serum ferritin concentration in Korean men.
abstract: BACKGROUND
  Despite accumulating evidence suggesting the clinical association between serum ferritin concentrations and diabetes, it is not clearly identified in other ethnic groups besides western population. This study analyzed a longitudinal relationship between serum ferritin concentration and the risk for diabetes in non-diabetic Korean men.
  
  
  METHODS
  This study was composed of a cohort of 30,002 non-diabetic Korean men who participated in medical health check-up program in 2005. They were divided into 4 groups according to their baseline ferritin concentrations (first quartile-fourth quartile) and monitored until 2010. Their incidences and hazard ratios of diabetes were compared among 4 groups according to their baseline ferritin concentrations.
  
  
  RESULTS
  While 2655 cases of diabetes newly developed during follow-up, incidence of diabetes increased proportionally to the baseline serum ferritin concentrations. In Cox-proportional hazard model, hazard ratios for diabetes also independently increased according to the baseline serum ferritin concentrations [quartile 1: 1.00 (reference), quartile 2: 1.00 (0.87-1.12), quartile 3: 1.13 (1.00-1.29), quartile 4: 1.18 (1.04-1.34), respectively].
  
  
  CONCLUSIONS
  Increased ferritin concentration was associated with increased risk for diabetes in Korean men. These findings suggest the clinical significance of serum ferritin concentration in the development diabetes.
authors.affiliation: Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Sunyong
authors.initials: S
authors.lastname: Kim
authors.affiliation: Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Sung Keun
authors.initials: SK
authors.lastname: Park
authors.affiliation: Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. Electronic address: armani131@naver.com.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Ryoo
authors.affiliation: Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Joong-Myung
authors.initials: JM
authors.lastname: Choi
authors.affiliation: Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Hong
authors.affiliation: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors.forename: Jai Hyung
authors.initials: JH
authors.lastname: Park
authors.affiliation: Institute of Clinical Research, School of Medicine, Inha University, Incheon, Republic of Korea.
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Suh
authors.affiliation: Departments of Internal Medicine, Bucheon Daesung Hospital, Gyeonggi-do, Republic of Korea.
authors.forename: Young-Sang
authors.initials: YS
authors.lastname: Byoun
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005293:Ferritins / Q000097:blood*; D006801:Humans; D008297:Male; D056910:Republic of Korea; D012307:Risk Factors
chemical_list: D005293:Ferritins
keywords: Cohort; Diabetes; Ferritin