title: Antigen-specific IgA titres after 23-valent pneumococcal vaccine indicate transient antibody deficiency disease in children.
abstract: Paediatric patients with antibody deficiency may either be delayed in development of humoral immunity or may be persistently deficient in antibody production. To differentiate between these entities, we examined the 23-valent pneumococcal polysaccharide (PnPS) vaccine-induced IgM-, IgG- and IgA antibody responses in a cohort of 66 children with recurrent respiratory tract infections. Individual serum titres against 11 pneumococcal serotypes were measured by Luminex. The cohort contained 33 antibody deficiency patients, 17 transient antibody deficiency patients and 16 patients without antibody deficiency diagnosis (control group). Transient antibody deficiency patients produced consistently higher levels of PnPS-specific IgA responses than antibody deficiency patients. Decreased IgA responses to serotypes 1, 5, 7F and 18C were most discriminative to stratify transient antibody deficiency patients from antibody deficiency patients with persistent disease. We conclude that measuring PnPS-specific IgA responses may predict the disease course in young children diagnosed with antibody deficiency and suggest confirmation of these data in a prospective setting.
authors.affiliation: Department of Pediatric Immunology and Infectious Diseases/Laboratory of Translational Immunology, Wilhelmina Children's Hospital, University Medical Center, Lundlaan 6, 3508 AB Utrecht, The Netherlands.
authors.forename: Willemijn J M
authors.initials: WJ
authors.lastname: Janssen
authors.affiliation: Department of Medical Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Stefan
authors.initials: S
authors.lastname: Nierkens
authors.affiliation: Department of Pediatric Immunology and Infectious Diseases/Laboratory of Translational Immunology, Wilhelmina Children's Hospital, University Medical Center, Lundlaan 6, 3508 AB Utrecht, The Netherlands; Department of Medical Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Sanders
authors.affiliation: Department of Pediatric Immunology and Infectious Diseases/Laboratory of Translational Immunology, Wilhelmina Children's Hospital, University Medical Center, Lundlaan 6, 3508 AB Utrecht, The Netherlands.
authors.forename: Marianne
authors.initials: M
authors.lastname: Boes
authors.affiliation: Department of Pediatric Immunology and Infectious Diseases/Laboratory of Translational Immunology, Wilhelmina Children's Hospital, University Medical Center, Lundlaan 6, 3508 AB Utrecht, The Netherlands. Electronic address: J.vanMontfrans@umcutrecht.nl.
authors.forename: Joris M
authors.initials: JM
authors.lastname: van Montfrans
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D012189:Retrospective Studies
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D022242:Pneumococcal Vaccines
keywords: Antibody deficiencies; CVID; IgA; Pneumococcal polysaccharide serotypes; Transient hypogammaglobulinemia of infancy