title: A Case of Probable MHC Class II Deficiency with Disseminated BCGitis.
abstract: Major histocompatibility complex (MHC) class II deficiency is a primary immunodeficiency disease characterized by abnormality of MHC class II molecules surface expression on peripheral blood lymphocytes and monocytes. Clinical manifestations include extreme susceptibility to viral, bacterial, and fungal infections but the immunodeficiency is not as severe as SCID (severe combined immunodeficiency), as evidenced by failure to develop disseminated infection after BCG vaccination. Therefore, MHC II deficiency with BCGosis, that is disseminated BCGitis, is not reported commonly. We report an interesting case of BCGosis after vaccination that was diagnosed to have probable MHC II deficiency.
authors.affiliation: Clinical Immunology and Allergy, Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, e-mail: alyasins@sums.ac.ir.
authors.forename: Soheyla
authors.initials: S
authors.lastname: Alyasin
authors.forename: Farhad
authors.initials: F
authors.lastname: Abolnezhadian
authors.forename: Maryam
authors.initials: M
authors.lastname: Khoshkhui
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D001921:Brain / Q000276:immunology / Q000382:microbiology*; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000175:diagnosis*; D007223:Infant; D008168:Lung / Q000276:immunology / Q000382:microbiology*; D009163:Mycobacterium bovis / Q000276:immunology* / Q000302:isolation & purification; D011014:Pneumonia / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D014375:Tuberculoma / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control
chemical_list: D000995:Antitubercular Agents; D001500:BCG Vaccine