title: [The specific features of diagnosis of mixed-phenotype acute leukemia: A combination of B-cell antigen expressions according to the results of flow cytometry and morphological markers of myeloid differentiation in blast cells: A clinical case].
abstract: This rare type of acute leukemia, blast cells of which express myeloid and/or lymphoid markers, is mainly diagnosed using flow cytometric findings. The paper describes a clinical case of mixed-phenotype acute leukemia, in which B-cell lymphoid antigen expressions were revealed by a flow cytometric technique, while bone marrow morphological specimens showed the signs of myeloid differentiation specific to blast cells. It is concluded that there is a need for a comprehensive examination of patients with new-onset acute leukemia and for an aggregate analysis of flow cytometric results with morphological and cytochemical findings.
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Gritsaev
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Kostroma
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: G M
authors.initials: GM
authors.lastname: Ryadnova
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Tiranova
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: Zh V
authors.initials: ZV
authors.lastname: Chubukina
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Balashova
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Zenina
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Martynkevich
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Potikhonova
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: K M
authors.initials: KM
authors.lastname: Abdulkadyrov
mesh_terms: D000208:Acute Disease; D000328:Adult; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000276:immunology; D010641:Phenotype; D013234:Stem Cells / Q000473:pathology*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor