title: Does occupational exposure to anesthetic gases lead to increase of pro-inflammatory cytokines?
abstract: BACKGROUND
  There is great concern about the possible harmful effects of exposure to volatile anesthetics. The current study aimed at evaluating, for the first time, the effects of occupational exposure to anesthetic gases on physicians who work in operating rooms, by determining several inflammatory cytokines.
  
  
  METHODS
  Plasma inflammatory cytokines (IL-1β, -6, -8, -10, -12, TNF-α) were investigated in 30 individuals who were allocated into two groups of 15: the exposed group, consisting of operating room medical personnel exposed to a mixture of anesthetic gases for 3 years, and a control group composed of medical personnel not exposed to anesthetic gases. The concentrations of volatile anesthetics were measured in the operating room by means of an infrared portable analyzer
  
  
  CONCLUSIONS
  Our findings suggest an increase of the pro-inflammatory IL-8 (p<0.05) in medical personnel exposed to high concentrations of anesthetic gases, even for a relatively short period.
authors.affiliation: Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil.
authors.forename: Maurício Martins
authors.initials: MM
authors.lastname: Chaoul
authors.affiliation: Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil.
authors.forename: José Reinaldo C
authors.initials: JR
authors.lastname: Braz
authors.affiliation: Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil.
authors.forename: Lorena Mendes C
authors.initials: LM
authors.lastname: Lucio
authors.affiliation: Faculdade de Medicina de Botucatu, Divisão de Hemocentro, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil.
authors.forename: Márjorie A
authors.initials: MA
authors.lastname: Golim
authors.affiliation: Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil.
authors.forename: Leandro Gobbo
authors.initials: LG
authors.lastname: Braz
authors.affiliation: Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil. mgbraz@hotmail.com.
authors.forename: Mariana Gobbo
authors.initials: MG
authors.lastname: Braz
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000009:adverse effects* / Q000032:analysis; D016207:Cytokines / Q000096:biosynthesis*; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000378:metabolism*; D016209:Interleukin-8 / Q000096:biosynthesis; D007378:Interleukins / Q000096:biosynthesis; D007530:Isoflurane / Q000009:adverse effects / Q000032:analysis; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects / Q000032:analysis; D009609:Nitrous Oxide / Q000009:adverse effects / Q000032:analysis; D016273:Occupational Exposure / Q000009:adverse effects*; D009873:Operating Rooms; D000077149:Sevoflurane; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D018685:Anesthetics, Inhalation; C508606:CXCL8 protein, human; D016207:Cytokines; D016209:Interleukin-8; D007378:Interleukins; D008738:Methyl Ethers; D014409:Tumor Necrosis Factor-alpha; D000077149:Sevoflurane; D007530:Isoflurane; D009609:Nitrous Oxide
keywords: Anesthetics; Cytokines; Occupational exposure; Toxicity