title: A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.
abstract: By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections.
authors.affiliation: Division of Chemistry, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping (Sweden).
authors.forename: Hamid
authors.initials: H
authors.lastname: Shirani
authors.affiliation: Division of Theoretical Chemistry, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping (Sweden).
authors.forename: Mathieu
authors.initials: M
authors.lastname: Linares
authors.affiliation: Department of Pathology, University of California, San Diego, La Jolla, California 92093-0612 (USA).
authors.forename: Christina J
authors.initials: CJ
authors.lastname: Sigurdson
authors.affiliation: Division of Chemistry, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping (Sweden).
authors.forename: Mikael
authors.initials: M
authors.lastname: Lindgren
authors.affiliation: Division of Theoretical Chemistry, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping (Sweden).
authors.forename: Patrick
authors.initials: P
authors.lastname: Norman
authors.affiliation: Division of Chemistry, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping (Sweden). petni@ifm.liu.se.
authors.forename: K Peter R
authors.initials: KP
authors.lastname: Nilsson
mesh_terms: D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism; D001923:Brain Chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D008024:Ligands; D066329:Protein Aggregates / Q000187:drug effects*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000682:Amyloid; D005456:Fluorescent Dyes; D008024:Ligands; D066329:Protein Aggregates; D013876:Thiophenes
keywords: Alzheimer’s disease; fluorescent probes; luminescence; microscopy; oligothiophenes