title: Effects on Spatial Cognition and Nociceptive Behavior Following Peripheral Nerve Injury in Rats with Lesion of the Striatal Marginal Division Induced by Kainic Acid.
abstract: Neuropathic pain and cognitive deficit are frequently comorbidity in clinical, but their underlying correlation and mechanisms remain unclear. Here, we utilized a combined rat model including kainic acid (KA) injection into bilateral striatal marginal division and chronic constriction nerve injury (CCI). PET/CT scans revealed that the SUVmax of KA rats was significantly decreased when compared to naive and saline rats. In contrast to the naive and saline rats, KA rats had longer latencies in locating the hidden platform on day 4, 5 in Morris water maze task. Thermal hyperalgesia and mechanical allodynia of KA rats were alleviated following CCI. Immunostaining results showed that substance P was markedly increased within ipsilateral spinal cord dorsal horn of KA rats after CCI, especially on the post-operative day 14. By means of real-time PCR, the up-regulation of GluR within ipsilateral spinal cord dorsal horn was observed in all KA and CCI rats. PKCγ, IL-6 and NF-κB were up-regulated in both CCI rats when compared to naive and their respective sham rats. These results suggest that cognitive impairment of rats altered the pain behaviors, and these intracellular regulators play crucial roles in the process of neuropathic pain.
authors.affiliation: Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
authors.forename: Chang
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
authors.forename: Guoying
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Physiology, Southern Medical University, Guangzhou, People's Republic of China.
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
authors.forename: Yuyun
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Physiology, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China. myx117@163.com.
authors.forename: Sumin
authors.initials: S
authors.lastname: Tian
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003342:Corpus Striatum / Q000473:pathology*; D018691:Excitatory Amino Acid Antagonists / Q000633:toxicity*; D018836:Inflammation Mediators / Q000378:metabolism; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D059225:Nociception / Q000187:drug effects*; D010146:Pain / Q000523:psychology*; D059348:Peripheral Nerve Injuries / Q000139:chemically induced / Q000473:pathology / Q000523:psychology*; D020671:Posterior Horn Cells / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013028:Space Perception / Q000187:drug effects*; D013373:Substance P / Q000378:metabolism
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018836:Inflammation Mediators; D013373:Substance P; D007608:Kainic Acid
keywords: Cognitive deficit; Kainic acid; Marginal division; Neuropathic pain; Spinal cord