title: Efficacy of plasmapheresis for the treatment of pure red blood cell aplasia after allogeneic stem cell transplantation.
abstract: BACKGROUND
  Pure red blood cell aplasia (PRCA) is a complication of ABO major-incompatible stem cell transplantation, likely due to the persistence of memory B lymphocytes of recipient origin, which produce hemagglutinins against ABO antigens on donor RBCs. At present no standard of care is established for this complication.
  
  
  METHODS
  We report a case of PRCA after allogeneic bone marrow transplantation, successfully treated with plasma exchange (PEX) after failing erythropoietin administration.
  
  
  RESULTS
  The patient fully recovered from RBC aplasia.
  
  
  CONCLUSIONS
  This case suggests a role for PEX in the treatment of PRCA after allogeneic stem cell transplantation.
authors.affiliation: SSCVD Trapianto di Cellule Staminali Allogeniche, AOU Cittaà della Salute e della Scienza.
authors.forename: Chiara Maria
authors.initials: CM
authors.lastname: Dellacasa
authors.affiliation: SC Ematologia, AOU Città della Salute e della Scienza.
authors.forename: Stefano
authors.initials: S
authors.lastname: D'Ardia
authors.affiliation: SC Ematologia, AOU Città della Salute e della Scienza.
authors.forename: Bernardino
authors.initials: B
authors.lastname: Allione
authors.affiliation: SC Ematologia, AOU Città della Salute e della Scienza.
authors.forename: Semra
authors.initials: S
authors.lastname: Aydin
authors.affiliation: SC Banca del Sangue, AOU Città della Salute e della Scienza.
authors.forename: Valter
authors.initials: V
authors.lastname: Tassi
authors.affiliation: SC Banca del Sangue, AOU Città della Salute e della Scienza.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Francisci
authors.affiliation: SC Immunopatologia e Malattie Rare, Ospedale San Giovanni Bosco, Torino, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Pecoraro
authors.affiliation: SSCVD Trapianto di Cellule Staminali Allogeniche, AOU Cittaà della Salute e della Scienza.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Busca
mesh_terms: D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010956:Plasmapheresis; D012010:Red-Cell Aplasia, Pure / Q000628:therapy*; D014184:Transplantation, Homologous