title: The effect of superdisintegrants on the properties and dissolution profiles of liquisolid tablets containing rosuvastatin.
abstract: BACKGROUND
  The preparation of liquisolid systems (LSS) represents a promising method for enhancing a dissolution rate and bioavailability of poorly soluble drugs. The release of the drug from LSS tablets is affected by many factors, including the disintegration time.
  
  
  OBJECTIVE
  The evaluation of differences among LSS containing varying amounts and types of commercially used superdisintegrants (Kollidon® CL-F, Vivasol® and Explotab®).
  
  
  METHODS
  LSS were prepared by spraying rosuvastatin solution onto Neusilin® US2 and further processing into tablets. Varying amounts of superdisintegrants were used and the differences among LSS were evaluated. The multiple scatter plot method was used to visualize the relationships within the obtained data.
  
  
  CONCLUSIONS
  All disintegrants do not showed negative effect on the flow properties of powder blends. The type and concentration of superdisintegrant had an impact on the disintegration time and dissolution profiles of tablets. Tablets with Explotab® showed the longest disintegration time and the smallest amount of released drug. Fastest disintegration and dissolution rate were observed in tablets containing Kollidon® CL-F (≥2.5% w/w). Also tablets with Vivasol® (2.5-4.0% w/w) showed fast disintegration and complete drug release.
  
  
  CONCLUSIONS
  Kollidon® CL-F and Vivasol® in concentration ≥2.5% are suitable superdisintegrants for LSS with enhanced release of drug.
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , University of Veterinary and Pharmaceutical Sciences , Palackeho Trida 1/3 , Brno , Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Vraníková
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , University of Veterinary and Pharmaceutical Sciences , Palackeho Trida 1/3 , Brno , Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Gajdziok
authors.affiliation: a Department of Pharmaceutics, Faculty of Pharmacy , University of Veterinary and Pharmaceutical Sciences , Palackeho Trida 1/3 , Brno , Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Doležel
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry*; D000924:Anticholesteremic Agents / Q000008:administration & dosage* / Q000737:chemistry; D004339:Drug Compounding; D065546:Drug Liberation; D017616:Magnesium Compounds / Q000737:chemistry*; D010592:Pharmaceutic Aids / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage* / Q000737:chemistry; D017640:Silicates / Q000737:chemistry*; D012995:Solubility; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry; D013607:Tablets / Q000737:chemistry
chemical_list: D017607:Aluminum Compounds; D000924:Anticholesteremic Agents; D017616:Magnesium Compounds; D010592:Pharmaceutic Aids; D017640:Silicates; D013607:Tablets; C033065:aluminum magnesium silicate; D000068718:Rosuvastatin Calcium; D013213:Starch; C048390:sodium starch glycolate; D011205:Povidone
keywords: Data visualization; disintegration time; dissolution profile; liquisolid systems; superdisintegrant