title: Dimercaptopropane Sulfonate Chelation Affects In Vivo Hg and MeHg Distribution in Tissues and Urine of Prairie Voles (Microtus ochrogaster).
abstract: Methyl mercury cation (MeHg(+)) and divalent mercury (Hg(2+)) were quantified in urine, liver, kidney, and brain of prairie voles (Microtus ochrogaster) during a 12 week exposure to aqueous MeHg(+) at concentrations of 10, 100, and 1000 ng MeHg(+)/mL. Aqueous MeHg(+) exposures increased mercury accumulation in tissues of voles from each exposure group. Accumulation was greater within the higher two exposure groups. Similar [Hg(2+)] and [MeHg(+)] were determined within a given organ type before and after 2,3-dimercapto-1-propane sulfonate (DMPS) chelation. Similar correlations were seen for Hg(2+) and MeHg(+) concentrations in pre and post chelation urine. Post chelation urine more reliably predicted mercury species concentrations in tissues than did urine collected before chelation. These data demonstrate the utility of DMPS in noninvasive assessment of wildlife exposure to mercury, which may have utility in evaluating meta-population level exposure to hazardous wastes.
authors.affiliation: Department of Environmental Science, Baylor University, Waco, TX, 76798, USA. George_cobb@baylor.edu.
authors.forename: G P
authors.identifier: http://orcid.org/0000-0001-8675-1283
authors.initials: GP
authors.lastname: Cobb
authors.affiliation: Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX, 79409, USA.
authors.forename: A W
authors.initials: AW
authors.lastname: Moore
authors.affiliation: Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX, 79409, USA.
authors.forename: K T
authors.initials: KT
authors.lastname: Rummel
authors.affiliation: Department of Biology, Oklahoma State University, Stillwater, OK, 74078, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: McMurry
mesh_terms: D000818:Animals; D003411:Arvicolinae / Q000378:metabolism* / Q000652:urine; D001921:Brain / Q000378:metabolism; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology; D004784:Environmental Monitoring / Q000379:methods*; D065948:Grassland; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008628:Mercury / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D008767:Methylmercury Compounds / Q000737:chemistry / Q000378:metabolism* / Q000652:urine
chemical_list: D002614:Chelating Agents; D008767:Methylmercury Compounds; C073972:dimethyl mercury; D008628:Mercury
keywords: Accumulation; Excretion; Exposure assessment; Mercury; Nonlethal