title: Possibility of lanthanum absorption in the stomach.
abstract: Lanthanum carbonate (LC) is an orally administered phosphate binder. Its absorption is generally thought to be minimal. We report here the case of an 81-year-old woman who underwent subtotal gastrectomy for gastric cancer after receiving hemodialysis for 1 year and taking LC for 7 months. Lanthanum phosphate compounds were found histologically in the gastric mucosa and a regional lymph node and confirmed by scanning and transmission electron microscopy-energy-dispersive X-ray spectroscopy. These findings suggest that lanthanum is absorbed in the stomach and transported via lymph flow. This observation could prove helpful in future investigation of lanthanum disposition.
authors.affiliation: Department of Diagnostic Pathology , Kanto Rosai Hospital , Kanagawa , Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Tonooka
authors.affiliation: Department of Nephrology , Kanto Rosai Hospital , Kanagawa , Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Uda
authors.affiliation: Department of Diagnostic Pathology , Kanto Rosai Hospital , Kanagawa , Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Department of Nephrology , Kanto Rosai Hospital , Kanagawa , Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yao
authors.affiliation: Department of Diagnostic Pathology , Kanto Rosai Hospital , Kanagawa , Japan.
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Uekusa
keywords: absorption; dialysis; lanthanum; lymph node; stomach