title: Morphologic manifestations of testicular and epididymal toxicity.
abstract: Histopathologic examination of the testis is the most sensitive means to detect effects on spermatogenesis; however, the complexity of testicular histology, interrelatedness of cell types within the testis, and long duration of spermatogenesis can make assessment of a testicular toxicant challenging. A thorough understanding of the histology and morphologic manifestations of response to injury is critical to successfully identify a testicular effect and to begin to understand the underlying mechanism of action. The basic patterns of response to xenobiotic-induced injury to the testis and epididymis are detailed and discussed.
authors.affiliation: GSK ; King of Prussia, PA USA.
authors.forename: Justin D
authors.initials: JD
authors.lastname: Vidal
authors.affiliation: AbbVie; GPRD Preclinical Safety ; Chicago, IL USA.
authors.forename: Katharine M
authors.initials: KM
authors.lastname: Whitney
keywords: cynomolgus monkey; dog; epididymis; histopathology; mouse; rat; testis; toxicity