title: Parathyroid Hormone as a Novel Biomarker for Chronic Obstructive Pulmonary Disease: Korean National Health and Nutrition Examination Survey.
abstract: OBJECTIVE
  To understand and predict chronic obstructive pulmonary disease (COPD), a biomarker that reflects disease severity is needed.
  
  
  METHODS
  Data from 10269 adults aged over 40 years of age were retrieved from the Korea National Health and Nutrition Examination Survey (KNHANES), and 1302 patients met the criteria for COPD. The association between values of vitamin D and parathyroid hormone (PTH), and COPD severity including lung function and quality of life, were analyzed.
  
  
  RESULTS
  In COPD patients, lung function was inversely related to PTH values (P = 0.02 for FVC [% predicted]; P < 0.001 for FEV1 [% predicted]); however, the association of lung function with vitamin D levels was not statistically significant in a multivariable analysis. Value of PTH was independently associated with EQ5D-index (P = 0.04), but vitamin D level showed no significant relationship with EQ5D-index (P = 0.59) or EQ5D-VAS (P = 0.81).
  
  
  CONCLUSIONS
  Elevation of PTH, unlike vitamin D, is independently associated with COPD severity, and may be a better biomarker for COPD.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University college of Medicine, Goyang, Korea.
authors.forename: Joo-Hyun
authors.initials: JH
authors.lastname: Park
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University college of Medicine, Goyang, Korea.
authors.forename: Hye Kyeong
authors.initials: HK
authors.lastname: Park
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University college of Medicine, Goyang, Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Jung
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University college of Medicine, Goyang, Korea.
authors.forename: Sung-Soon
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University college of Medicine, Goyang, Korea.
authors.forename: Hyeon-Kyoung
authors.initials: HK
authors.lastname: Koo
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009749:Nutrition Surveys; D010281:Parathyroid Hormone / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000503:physiopathology*; D011788:Quality of Life; D056910:Republic of Korea; D012129:Respiratory Function Tests; D014807:Vitamin D / Q000097:blood
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D014807:Vitamin D