title: Association of CCR5Δ32 and Behçet's disease: new data from a case-control study in the Spanish population and meta-analysis.
abstract: OBJECTIVE
  Behçet's disease (BD) is an immune-mediated and complex disease associated with HLA class I and other genes. The aim of this study was to contribute to a better understanding of the relationship of the 32-bp deletion in the CCR5 gene (CCR5Δ32) and this disease by conducting a case-control study in the Spanish population and also a meta-analysis including all the studies available to date.
  
  
  METHODS
  A cohort composed of 348 BD Spanish patients and 477 unrelated healthy and ethnically matched individuals were genotyped in CCR5Δ32 using polymerase chain reaction (PCR) and capillary electrophoresis with fluorescent detection. In the meta-analysis, data from a total of seven populations extracted from four previous studies along with data of the present study were included.
  
  
  RESULTS
  Regarding the case-control study, no statistically significant differences were observed when the patient and control groups were compared (allelic model: 0.07 in patients vs. 0.06 in controls, p=0.303). In the meta-analysis, no evidence of association of the CCR5Δ32 polymorphism with BD was observed (pMH=0.091; OR=1.22; 95%CI 0.98 to 1.52 in the allelic model).
  
  
  CONCLUSIONS
  The results of this meta-analysis discard a major role of the CCR5Δ32 polymorphism in BD.
authors.affiliation: Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Ortiz-Fernández
authors.affiliation: Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Jose-Raul
authors.initials: JR
authors.lastname: García-Lozano
authors.affiliation: Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Marco-Antonio
authors.initials: MA
authors.lastname: Montes-Cano
authors.affiliation: Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Conde-Jaldón
authors.affiliation: Servicio de Medicina Interna, Hospital Clínico San Cecilio, Granada, Spain.
authors.forename: Norberto
authors.initials: N
authors.lastname: Ortego-Centeno
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
authors.forename: Maria-Jesus
authors.initials: MJ
authors.lastname: Castillo-Palma
authors.affiliation: Servicio de Enfermedades Autoinmunes, Hospital Clinic, Barcelona, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Espinosa
authors.affiliation: Servicio de Reumatología, Complejo Hospitalario Universitario, A Coruña, Spain.
authors.forename: Genaro
authors.initials: G
authors.lastname: Graña-Gil
authors.affiliation: Servicio de Reumatología, Hospital Universitario de Valme, Sevilla, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Sánchez-Bursón
authors.affiliation: Servicio de Inmunología, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Juliá
authors.affiliation: Servicio de Reumatología, Hospital Marqués de Valdecilla, Santander, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Blanco
authors.affiliation: Servicio de Medicina Interna, Hospital de Torrecárdenas, Almería, Spain.
authors.forename: Ana-Celia
authors.initials: AC
authors.lastname: Barnosi-Marín
authors.affiliation: Servicio de Medicina Interna, Hospital Vall d'Hebron, Barcelona, Spain.
authors.forename: Roser
authors.initials: R
authors.lastname: Solans
authors.affiliation: Servicio de Medicina Interna, Hospital Virgen del Camino, Pamplona, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Fanlo
authors.affiliation: Servicio de Medicina Interna, Hospital Universitari Mútua, Terrassa, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Rodríguez-Carballeira
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario Carlos Haya, Málaga, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Camps
authors.affiliation: Servicio de Reumatología, Hospital de la Princesa, Madrid, Spain.
authors.forename: Santos
authors.initials: S
authors.lastname: Castañeda
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Martín
authors.affiliation: Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain. mariaf.gonzalez.sspa@juntadeandalucia.es.
authors.forename: Maria-Francisca
authors.initials: MF
authors.lastname: González-Escribano
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D019713:Receptors, CCR5 / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain
chemical_list: C584933:CCR5 protein, human; D019713:Receptors, CCR5