title: MicroRNAs; easy and potent targets in optimizing therapeutic methods in reparative angiogenesis.
abstract: The age-related senescence of adult tissues is associated with the decreased level of angiogenic capability and with the development of a degenerative disease such as atherosclerosis which thereafter result in the deteriorating function of multiple systems. Findings indicate that tissue senescence not only diminishes repair processes but also promotes atherogenesis, serving as a double-edged sword in the development and prognosis of ischaemia-associated diseases. Evidence evokes microRNAs (miRNAs) as molecular switchers that underlie cellular events in different tissues. Here, miRNAs would promote new potential targets for optimizing therapeutic methods in blood flow recovery to the ischaemic area. Effectively beginning an ischaemia therapy, a more characteristic of miRNA changes in adult tissues is prerequisite and in the forefront. It may also be a preliminary phase in treatment strategies by stem cell-based therapy.
authors.affiliation: School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.|Department of Clinical Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Pourrajab
authors.affiliation: School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Vakili Zarch
authors.affiliation: Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Seyedhossein
authors.initials: S
authors.lastname: Hekmatimoghaddam
authors.affiliation: School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Zare-Khormizi
mesh_terms: D050197:Atherosclerosis / Q000150:complications / Q000235:genetics*; D020869:Gene Expression Profiling; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000235:genetics*; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008957:Models, Genetic; D009389:Neovascularization, Pathologic / Q000150:complications / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs
keywords: angiogenesis; microRNAs; treatment strategies