title: Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions.
abstract: Cell-cycle fluctuations drive significant transcriptomic heterogeneity in murine hematopoietic stem cells. Additionally, deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice.
authors.affiliation: New York Genome Center, New York, NY, 10012, USA. rsatija@nygenome.org.|New York University, Center for Genomics and Systems Biology, New York, NY, 10012, USA. rsatija@nygenome.org.
authors.forename: Ashley N
authors.initials: AN
authors.lastname: Powers
authors.affiliation: New York Genome Center, New York, NY, 10012, USA. rsatija@nygenome.org.|New York University, Center for Genomics and Systems Biology, New York, NY, 10012, USA. rsatija@nygenome.org.
authors.forename: Rahul
authors.initials: R
authors.lastname: Satija
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics; D004268:DNA-Binding Proteins; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism*; D059014:High-Throughput Nucleotide Sequencing; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics*; D012097:Repressor Proteins; D015398:Signal Transduction; D059010:Single-Cell Analysis; D034061:Thrombopoiesis / Q000235:genetics
chemical_list: C407733:Bcl11a protein, mouse; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins