title: Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.
abstract: OBJECTIVE
  Recent genome-wide association studies have identified several loci influencing lipid levels. The present study focused on the triglycerides (TG)-associated locus, the APOA4-APOA5-ZNF259-BUD13 gene cluster on chromosome 11, to explore the role of genetic variants in this gene cluster in the development of increasing TG levels and coronary heart disease (CHD).
  
  
  RESULTS
  Six single nucleotide polymorphisms (SNPs), rs4417316, rs651821, rs6589566, rs7396835, rs964184 and rs17119975, in the APOA4-APOA5-ZNF259-BUD13 gene cluster were selected and genotyped in 5374 healthy Chinese subjects. There were strong significant associations between the six SNPs and TG levels (P < 1.0 × 10(-8)). Moreover, a weighted genotype score was found to be associated with TG levels (P = 3.28 × 10(-13)). The frequencies of three common haplotypes were observed to be significantly different between the high TG group and the low TG group (P < 0.05). However, no significant effects were found for the SNPs regarding susceptibility to CHD in the Chinese case-control populations.
  
  
  CONCLUSIONS
  This study highlights the genotypes, genotype scores and haplotypes of the APOA4-APOA5-ZNF259-BUD13 gene cluster that were associated with TG levels in a Chinese population; however, the genetic variants in this gene cluster did not increase the risk of CHD in the Chinese population.
authors.affiliation: Department of Epidemiology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Qianxi
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Department of Epidemiology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Tang
authors.affiliation: The Second Affiliated Hospital and the Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: Molecular Medicine and Tumor Research Center, Chongqing Medical University, Yuzhong District in Chongqing, 400016, China.
authors.forename: Mingjun
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.affiliation: The Second Affiliated Hospital and the Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Jing
authors.affiliation: Department of Epidemiology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D044466:Asian People; D002352:Carrier Proteins / Q000235:genetics*; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics* / Q000473:pathology; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D026901:Membrane Transport Proteins; D008875:Middle Aged; D005810:Multigene Family; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins / Q000235:genetics*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; C000595434:BUD13 homolog protein, human; D002352:Carrier Proteins; D026901:Membrane Transport Proteins; D016601:RNA-Binding Proteins; D014280:Triglycerides; C099746:ZPR1 protein, human; C022205:apolipoprotein A-IV