title: Tumor-infiltrating myeloid cells drive senescence evasion and chemoresistance in tumors.
abstract: The present study supports a model in whichPtenloss-induced senescence is hindered in prostate tumor cells by non cell-autonomous mechanisms. Indeed, paracrine signaling by tumor-infiltrating CD11b+Gr-1+myeloid cells triggers senescence evasion in prostate lesions ofPten-null mice, eventually promoting tumor progression.
authors.affiliation: Institute of Oncology Research (IOR); Oncology Institute of Southern Switzerland ; Bellinzona, Switzerland.
authors.forename: Diletta
authors.initials: D
authors.lastname: Di Mitri
authors.affiliation: Institute of Oncology Research (IOR); Oncology Institute of Southern Switzerland ; Bellinzona, Switzerland.
authors.forename: Alberto
authors.initials: A
authors.lastname: Toso
authors.affiliation: Institute of Oncology Research (IOR); Oncology Institute of Southern Switzerland ; Bellinzona, Switzerland.
authors.forename: Andrea
authors.initials: A
authors.lastname: Alimonti