title: Tackling reproducibility in academic preclinical drug discovery.
abstract: The reproducibility of biomedical research on novel drug targets has become suspect. Here, we highlight how drug discovery centres embedded in academic institutions, but with a translational imperative, can help address this reproducibility crisis.
authors.affiliation: Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7363, USA.
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Frye
authors.affiliation: Small Molecule Discovery Center, School of Pharmacy, University of California at San Francisco, 1700 4th Street, Box 2552, San Francisco, California 94143, USA.
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Arkin
authors.affiliation: Structural Genomics Consortium, University of Toronto, Suite 700, MaRS South Tower, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
authors.forename: Cheryl H
authors.initials: CH
authors.lastname: Arrowsmith
authors.affiliation: Vanderbilt Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, 1205 LH, Nashville, Tennessee 37232-0697, USA.
authors.forename: P Jeffrey
authors.initials: PJ
authors.lastname: Conn
authors.affiliation: ORIG3N, 27 Drydock Avenue, Boston, Massachusetts 02210, USA.
authors.forename: Marcie A
authors.initials: MA
authors.lastname: Glicksman
authors.affiliation: Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7363, USA.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Hull-Ryde
authors.affiliation: Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Rangos Suite 277, 855 North Wolfe Street, Baltimore, Maryland 21205, USA.
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Slusher
mesh_terms: D000046:Academic Medical Centers / Q000379:methods / Q000592:standards*; D000818:Animals; D035843:Biomedical Research / Q000379:methods / Q000592:standards*; D055808:Drug Discovery / Q000379:methods / Q000592:standards*; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000592:standards*; D006801:Humans; D015203:Reproducibility of Results; D057170:Translational Research, Biomedical / Q000379:methods / Q000592:standards