title: Bisacremines E-G, Three Polycyclic Dimeric Acremines Produced by Acremonium persicinum SC0105.
abstract: Three dimeric acremines, bisacremines E-G (1-3), with an unusual carbon skeleton were isolated from cultures of the soil-derived fungus Acremonium persicinum SC0105. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and ECD/TDDFT computations. Compound 3 exhibited inhibitory effects on the production of TNF-α, IL-6, and NO in LPS-stimulated macrophages. A biogenetic pathway with a [4 + 2] cycloaddition as the key reaction is proposed for 1-3.
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Xue
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yao
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
authors.forename: Liangxiong
authors.initials: L
authors.lastname: Xu
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
authors.forename: Hanxiang
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008264:Macrophages / Q000187:drug effects; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D012988:Soil Microbiology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects; D014961:X-Ray Diffraction; D000093242:Interleukin-6 Inhibitors
chemical_list: D009569:Nitric Oxide; D013729:Terpenes; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors; C439524:TNF protein, human; C000604176:bisacremine E; C000604178:bisacremine F; C000604179:bisacremine G