title: Effects of a diet containing genetically modified rice expressing the Cry1Ab/1Ac protein (Bacillus thuringiensis toxin) on broiler chickens.
abstract: The aim of this study was to evaluate the effect of feeding Bacillus thuringiensis (Bt) rice expressing the Cry1Ab/1Ac protein on broiler chicken. The genetically modified (GM) Bt rice was compared with the corresponding non-GM rice regarding performance of feeding groups, their health status, relative organ weights, biochemical serum parameters and occurrence of Cry1Ab/1Ac gene fragments. One hundred and eighty day-old Arbor Acres female broilers with the same health condition were randomly allocated to the two treatments (6 replicate cages with 15 broilers in each cage per treatment). They received diets containing GM rice (GM group) or its parental non-GM rice (non-GM group) at 52-57% of the air-dried diet for 42 days. The results show that the transgenic rice had a similar nutrient composition as the non-GM rice and had no adverse effects on chicken growth, biochemical serum parameters and necropsy during the 42-day feeding period. In birds fed the GM rice, no transgenic gene fragments were detected in the samples of blood, liver, kidneys, spleen, jejunum, ileum, duodenum and muscle tissue. In conclusion, the results suggest that Bt rice expressing Cry1Ab/1Ac protein has no adverse effects on broiler chicken. Therefore, it can be considered as safe and used as feed source for broiler chicken.
authors.affiliation: a State Key Laboratory of Animal Nutrition, Institute of Animal Sciences , Chinese Academy of Agricultural Sciences , Beijing , China.|b College of Animal Science and Technology , Anhui Agriculture University , Hefei , China.
authors.forename: Zeyang
authors.initials: Z
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Animal Nutrition, Institute of Animal Sciences , Chinese Academy of Agricultural Sciences , Beijing , China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: a State Key Laboratory of Animal Nutrition, Institute of Animal Sciences , Chinese Academy of Agricultural Sciences , Beijing , China.
authors.forename: Minhong
authors.initials: M
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Animal Nutrition, Institute of Animal Sciences , Chinese Academy of Agricultural Sciences , Beijing , China.
authors.forename: Jinghai
authors.initials: J
authors.lastname: Feng
authors.affiliation: a State Key Laboratory of Animal Nutrition, Institute of Animal Sciences , Chinese Academy of Agricultural Sciences , Beijing , China.
authors.forename: Yandan
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D000821:Animal Feed / Q000032:analysis / Q000382:microbiology*; D000818:Animals; D001413:Bacillus thuringiensis / Q000235:genetics*; D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000737:chemistry* / Q000235:genetics; D002645:Chickens / Q000502:physiology*; D004032:Diet / Q000662:veterinary*; D004731:Endotoxins / Q000008:administration & dosage / Q000737:chemistry* / Q000235:genetics; D005260:Female; D006460:Hemolysin Proteins / Q000008:administration & dosage / Q000737:chemistry* / Q000235:genetics; D008297:Male; D012275:Oryza / Q000737:chemistry* / Q000235:genetics / Q000382:microbiology; D030821:Plants, Genetically Modified / Q000737:chemistry / Q000235:genetics / Q000382:microbiology; D011897:Random Allocation
chemical_list: D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins; D004731:Endotoxins; D006460:Hemolysin Proteins; C030956:insecticidal crystal protein, Bacillus Thuringiensis
keywords: Bacillus thuringiensis; chickens; feed grains; food safety; genetically modified plant; rice