title: Synthesis of diversely substituted 2-(furan-3-yl)acetates from allenols through cascade carbonylations.
abstract: Novel synthesis of diversely substituted 2-(furan-3-yl)acetates via palladium-catalyzed one-pot multi-component reactions of allenols, aryl iodides, alcohols, and carbon monoxide has been developed. Notably, the formation of the title compounds features a cascade process combining carbonylation of aryl iodide, alcohoxyl carbonylation of the in situ formed allyl palladium complex, and intramolecular condensation of the α-hydroxyl enone intermediate. Moreover, the 2-(furan-3-yl)acetates obtained herein were found to be ready intermediates for the construction of the biologically significant naphtho[1,2-b]furan-5-ol scaffold.
authors.affiliation: School of Environment, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, P. R. China. xuesen.fan@htu.cn xinyingzhang@htu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.affiliation: School of Environment, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, P. R. China. xuesen.fan@htu.cn xinyingzhang@htu.cn.
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Environment, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, P. R. China. xuesen.fan@htu.cn xinyingzhang@htu.cn.
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000438:Alcohols / Q000737:chemistry*; D000466:Alkadienes / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D000085:Acetates; D000438:Alcohols; D000466:Alkadienes; D005663:Furans; D006847:Hydrocarbons, Iodinated; D010165:Palladium; D002248:Carbon Monoxide