title: Influence of self-assembly regenerated silk fibroin nanofibers on the properties of electrospun materials.
abstract: In this study, self-assembly regenerated silk fibroin (RSF) nanofibers were prepared and observed by Atomic Force Microscope (AFM). Then RSF films containing nanospheres and nanofibers were prepared and dissolved with poly (L-lactide-co-ε-caprolactone) (PLCL) with a blending ratio of 30/70 in hexafluoro-2-propanol (HFIP). In order to determine whether different nanostructures in the solution influence the morphological, structural, and mechanical properties of the final electrospun materials, flat membranes were prepared and characterized by Scanning Electron Microscope (SEM), Fourier Transform Infrared (FT-IR), and mechanical testing. The secondary structure of as-spun materials with RSF nanofibers were not changed, however, the diameter of electrospun fibers decreased and tensile strength and elongation at breaks increased. Electrospun materials with RSF nanofibers have the potential to be used for skin, cartilage, and blood vessels because of their biocompatibility and improved mechanical properties.
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, No. 199 Ren'ai Road, Industrial Park, Suzhou 215123, China.
authors.forename: Huijing
authors.initials: H
authors.lastname: Zhao
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, No. 199 Ren'ai Road, Industrial Park, Suzhou 215123, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Ren
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, No. 199 Ren'ai Road, Industrial Park, Suzhou 215123, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, No. 199 Ren'ai Road, Industrial Park, Suzhou 215123, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis*; D003460:Crystallization / Q000379:methods; D055119:Elastic Modulus; D004595:Electroplating / Q000379:methods*; D005349:Fibroins / Q000737:chemistry* / Q000648:ultrastructure; D008422:Materials Testing; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure*; D012399:Rotation; D013314:Stress, Mechanical; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D005349:Fibroins
keywords: Regenerated silk fibroin; artificial blood vessels; electrospinning; nanostructure; self-assembly