title: Reduced In Vitro Activity of Ceftaroline by Etest among Clonal Complex 239 Methicillin-Resistant Staphylococcus aureus Clinical Strains from Australia.
abstract: A total of 421 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMérieux). A multidrug resistant phenotype was found in 40.9%, and clonal complex 239 (CC239) was found in 33.5%. Ceftaroline nonsusceptibility (MIC, >1.0 μg/ml) was 16.9% overall. Nonsusceptibility was significantly higher in CC239 (41.1%, 58/141) and in isolates with a multidrug resistant phenotype (35.5%, 61/172) compared with comparators (P < 0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections.
authors.affiliation: Alfred Hospital, Melbourne, Victoria, Australia iainabbott@gmail.com.
authors.forename: I J
authors.initials: IJ
authors.lastname: Abbott
authors.affiliation: Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: A W J
authors.initials: AW
authors.lastname: Jenney
authors.affiliation: Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: C J
authors.initials: CJ
authors.lastname: Jeremiah
authors.affiliation: Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Mirčeta
authors.affiliation: Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
authors.forename: J P
authors.initials: JP
authors.lastname: Kandiah
authors.affiliation: Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
authors.forename: D C
authors.initials: DC
authors.lastname: Holt
authors.affiliation: Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
authors.forename: S Y C
authors.identifier: http://orcid.org/0000-0002-1368-8356
authors.initials: SY
authors.lastname: Tong
authors.affiliation: Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: D W
authors.initials: DW
authors.lastname: Spelman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001315:Australia; D002511:Cephalosporins / Q000494:pharmacology*; D002999:Clone Cells; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D008712:Methicillin; D000097583:Ceftaroline