title: Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis.
abstract: Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-analysis. Quality evaluation of the included studies was conducted by two physicians. Statistical analyses were carried out using the Stata 12.0 software for meta-analysis. Analyses of sensitivity and publication bias were also conducted. Overall, a significant association was found between the Arg188His polymorphism and ovarian cancer risk when all studies were pooled into the meta-analysis (Arg/Arg vs His/His: OR = 1.85, 95%CI = 1.15-3.00; Arg/Arg vs Arg/His: OR = 1.17, 95%CI = 1.03-1.32; dominant model: OR = 0.84, 95%CI = 0.74-0.95; recessive model: OR = 1.69, 95%CI = 1.05-2.70). This meta-analysis suggested that the XRCC2 Arg188His polymorphism was associated with the risk of ovarian cancer. Further large and well-designed studies are needed to confirm these conclusions.
authors.affiliation: Comprehensive Laboratory, Ningbo International Travel Healthcare Center, Ningbo, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhai
authors.affiliation: Comprehensive Laboratory, Ningbo International Travel Healthcare Center, Ningbo, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Laboratory Department, Hangzhou Cancer Hospital, Hangzhou, China jiangmf001@126.com.
authors.forename: M F
authors.initials: MF
authors.lastname: Jiang
mesh_terms: D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D010053:Ovary / Q000378:metabolism / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D004268:DNA-Binding Proteins; C113187:XRCC2 protein, human