title: Scleroderma renal crisis in tropical region: two senegalese cases.
abstract: Scleroderma renal crisis (SRC) is defined as the new onset of accelerated arterial hypertension and /or rapidly progressive oliguric renal failure during the course of systemic sclerosis. It is a rare but life-threatening complication. This formerly serious complication has got a considerable brighter outlook since the introduction of angiotensin converting enzyme inhibitors (ACE) however the mortality is still remaining high. We report two cases of SRC which to our knowledge are the firsts described in Dakar. They were two women aged 45 and 32 years, one of them was previously following for systemic sclerosis. Both of them had malignant hypertension associated with rapidly progressive renal failure, the other was put under corticosteroid therapy four months before SRC occurrence. The histological and laboratory finding showed thrombotic microangiopathy. The height blood pressure returned to normal value after treatment with ACE inhibitors. The final outcome was undesirable with the death of one after two months due to the hemodialysis discontinuation and persistence of renal failure in the other.
authors.affiliation: Nephrology Department of Teaching Hospital, Aristide le Dantec, Dakar, Sénégal.
authors.forename: Mouhamadou Moustapha
authors.initials: MM
authors.lastname: Cisse
authors.affiliation: Nephrology Department of Gaston Berger University, Saint Louis, Sénégal.
authors.forename: Sidy Mohamed
authors.initials: SM
authors.lastname: Seck
authors.affiliation: Nephrology Department of Teaching Hospital, Aristide le Dantec, Dakar, Sénégal.
authors.forename: Daher Abdoul Karim
authors.initials: DA
authors.lastname: Oumar
authors.affiliation: Nephrology Department of Teaching Hospital, Aristide le Dantec, Dakar, Sénégal.
authors.forename: Khodia
authors.initials: K
authors.lastname: Fall
authors.affiliation: Nephrology Department of Teaching Hospital, Aristide le Dantec, Dakar, Sénégal.
authors.forename: Ahmed Tall
authors.initials: AT
authors.lastname: Lemrabott
authors.affiliation: Dermatology Department of Teaching Hospital Aristide le Dantec, Dakar, Sénégal.
authors.forename: Moussa
authors.initials: M
authors.lastname: Diallo
authors.affiliation: Nephrology Department of Teaching Hospital, Aristide le Dantec, Dakar, Sénégal.
authors.forename: Maria
authors.initials: M
authors.lastname: Faye
authors.affiliation: Nephrology Department of Teaching Hospital, Aristide le Dantec, Dakar, Sénégal.
authors.forename: Moustapha
authors.initials: M
authors.lastname: Faye
authors.affiliation: Nephrology Department of Teaching Hospital, Aristide le Dantec, Dakar, Sénégal.
authors.forename: Abdou
authors.initials: A
authors.lastname: Niang
authors.affiliation: Nephrology Department of Teaching Hospital, Aristide le Dantec, Dakar, Sénégal.
authors.forename: Boucar
authors.initials: B
authors.lastname: Diouf
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy / Q000209:etiology*; D006977:Hypertension, Renal / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000188:drug therapy / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000150:complications*; D012675:Senegal
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors
keywords: Dakar; Scleroderma renal crisis; corticosteroids; thrombotic microangiopathy