title: Evaluation of wound healing effects between Salvadora persica ointment and Solcoseryl jelly in animal model.
abstract: In this research study very first time a herbal ointment contain 10% Salvadora persica extract was compared with Solcosseryl jelly 10% and blank Vaseline to evaluate wound healing effects using excision wound healing model in animals. Three groups of rats (n-6) were experimentally wounded on the back of their neck. Group I was dressed with Vaseline containing 10% test drug, Group II was treated with thin layer of Solcoseryl jelly 10% as reference drug while Group III was dressed with thin layer of blank Vaseline as control group. The effect of vehicle on rate of wound healing were assessed and in all cases there were progressive decreased in wound area with time but wound dress with Vaseline containing S. persica extract and wound treated with Solcosseryl jelly significantly healed earlier than those treated with Vaseline. It is concluded that S. persica extract significantly enhance the acceleration rate of wound enclosure in rats.
authors.affiliation: Pharmaceutical Research Centre PCSIR Laboratories Complex, Karachi, Pakistan.
authors.forename: Hina
authors.initials: H
authors.lastname: Imran
authors.affiliation: Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi, Pakistan.
authors.forename: Mansoor
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Pharmaceutical Research Centre PCSIR Laboratories Complex, Karachi, Pakistan.
authors.forename: Atiqur
authors.initials: A
authors.lastname: Rahman
authors.affiliation: Pharmaceutical Research Centre PCSIR Laboratories Complex, Karachi, Pakistan.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Yaqeen
authors.affiliation: Pharmaceutical Research Centre PCSIR Laboratories Complex, Karachi, Pakistan.
authors.forename: Tehmina
authors.initials: T
authors.lastname: Sohail
authors.affiliation: Pharmaceutical Research Centre PCSIR Laboratories Complex, Karachi, Pakistan.
authors.forename: Nudrat
authors.initials: N
authors.lastname: Fatima
authors.affiliation: Ishratul Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Wasif
authors.initials: W
authors.lastname: Iqbal
authors.affiliation: Pharmaceutical Research Centre PCSIR Laboratories Complex, Karachi, Pakistan.
authors.forename: Syed Shafay
authors.initials: SS
authors.lastname: Yaqeen
mesh_terms: D000183:Actihaemyl / Q000494:pharmacology*; D000818:Animals; D008297:Male; D023421:Models, Animal; D009824:Ointments; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D032121:Salvadoraceae; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D009824:Ointments; D010936:Plant Extracts; D000183:Actihaemyl