title: Association between self-reported snoring and arterial stiffness: data from the Brisighella Heart Study.
abstract: The correlation of both obstructive sleep apnoea syndrome (OSAS) and snoring with cardiovascular risk is well known, but its investigation is complex and not suitable for studying large cohorts of subjects. Thus, we prospectively evaluated 1476 non-pharmacologically treated subjects selected from the last survey of the Brisighella Heart Study. Snoring and sleep apnoea were investigated asking the subjects if they were aware of snoring during the night, and if this was associated with episodes of apnoea. A full set of clinical and laboratory parameters were evaluated, while augmentation index (AIx), and pulse wave velocity (PWV) were recorded with the Vicorder(®) apparatus. A logistic regression analysis identifies as main independent predictors of AIx age (OR 1.058, 95% CI 1.043-1.065, p < 0.001), Body Mass Index (OR 1.046, 95% CI 1.014-1.079, p = 0.005), and apolipoprotein B (OR 1.014, 95% CI 1.004-1.023, p = 0.001). The main independent predictors of PWV are snoring (OR 1.215, 95% CI 1.083-1.390, p < 0.001), and snoring with apnoea (OR 1.351, 95% CI 1.135-1.598, p = 0.014), age (OR 1.078, 95% CI 1.052-1.089, p < 0.001), serum uric acid [SUA] (OR 1.093, 95% CI 1.026-1.151, p < 0.001) and mean arterial pressure (OR 1.042, 95% CI 1.024-1.056, p < 0.001). In conclusion, in our cohort of overall healthy subjects, self-reported snoring and sleep apnoea are independently associated with a higher PVW, and AIx is statistically significantly higher in snorers with or without sleep apnoea than in non-snorers. Body Mass Index and apolipoprotein B are associated with AIx, while SUA and mean arterial pressure are related to PWV.
authors.affiliation: Medical and Surgical Sciences Department, U.O. Medicina Interna Borghi, Sant'Orsola-Malpighi University Hospital, University of Bologna, Via Albertoni, 15, 40138, Bologna, Italy. arrigo.cicero@unibo.it.
authors.forename: Arrigo F G
authors.initials: AF
authors.lastname: Cicero
authors.affiliation: Medical and Surgical Sciences Department, U.O. Medicina Interna Borghi, Sant'Orsola-Malpighi University Hospital, University of Bologna, Via Albertoni, 15, 40138, Bologna, Italy.
authors.forename: Martino
authors.initials: M
authors.lastname: Morbini
authors.affiliation: Medical and Surgical Sciences Department, U.O. Medicina Interna Borghi, Sant'Orsola-Malpighi University Hospital, University of Bologna, Via Albertoni, 15, 40138, Bologna, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Urso
authors.affiliation: Medical and Surgical Sciences Department, U.O. Medicina Interna Borghi, Sant'Orsola-Malpighi University Hospital, University of Bologna, Via Albertoni, 15, 40138, Bologna, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Rosticci
authors.affiliation: Medical and Surgical Sciences Department, U.O. Medicina Interna Borghi, Sant'Orsola-Malpighi University Hospital, University of Bologna, Via Albertoni, 15, 40138, Bologna, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Parini
authors.affiliation: Medical and Surgical Sciences Department, U.O. Medicina Interna Borghi, Sant'Orsola-Malpighi University Hospital, University of Bologna, Via Albertoni, 15, 40138, Bologna, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Grandi
authors.affiliation: Medical and Surgical Sciences Department, U.O. Medicina Interna Borghi, Sant'Orsola-Malpighi University Hospital, University of Bologna, Via Albertoni, 15, 40138, Bologna, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: D'Addato
authors.affiliation: Medical and Surgical Sciences Department, U.O. Medicina Interna Borghi, Sant'Orsola-Malpighi University Hospital, University of Bologna, Via Albertoni, 15, 40138, Bologna, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Borghi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007558:Italy; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D057566:Self Report; D020181:Sleep Apnea, Obstructive / Q000150:complications*; D012913:Snoring / Q000150:complications*; D059289:Vascular Stiffness; D055815:Young Adult
keywords: Arterial stiffness; Epidemiology; Sleep apnoea; Snoring