title: Lymphoid hyperplasia of the colon and its association with underlying allergic airway diseases.
abstract: OBJECTIVE
  The purpose of this study was to determine the prevalence of lymphoid hyperplasia in the lower gastrointestinal tract and its role in patients undergoing colonoscopic examinations, particularly focusing on any allergic predisposition.
  
  
  METHODS
  A database search performed at the Department of Gastroenterology at Onomichi Municipal Hospital identified seven patients with lymphoid hyperplasia in the large intestine (i.e., cecum, colon, and/or rectum). Data regarding the endoscopic, biological, and pathological examinations performed and the allergic histories for each patient were retrospectively reviewed from the clinical records.
  
  
  RESULTS
  Median age of the patients (four males, three females) was 50 years. Lymphoid hyperplasia was seen in the cecum (n = 5), ascending colon (n = 2), and transverse colon (n = 1). Six patients (85.7%) had one of the allergic airway diseases: allergic rhinoconjunctivitis for pollen (n = 3), bronchial asthma (n = 1), infantile asthma (n = 1), or allergic bronchitis (n = 1). Drug allergy (n = 3) and urticaria (n = 2) were also found. All seven patients had one or more allergic diseases; however, none had a history of food allergy. Blood tests for allergens revealed that six patients (85.7%) had positive reactions to inherent allergens, whereas only one patient had a positive reaction to food allergens.
  
  
  CONCLUSIONS
  Our results indicate that lymphoid hyperplasia in the large intestine may be associated with allergic airway diseases rather than with food allergies; thus, its presence may be useful to detect patients with underlying airway hyperreactivity.
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan. iwamuromasaya@yahoo.co.jp.|Department of Gastroenterology, Onomichi Municipal Hospital, Onomichi, 722-8503, Japan. iwamuromasaya@yahoo.co.jp.
authors.forename: Masaya
authors.initials: M
authors.lastname: Iwamuro
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Hiraoka
authors.affiliation: Department of Endoscopy, Okayama University Hospital, Okayama, 700-8558, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.affiliation: Department of Gastroenterology, Onomichi Municipal Hospital, Onomichi, 722-8503, Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Kawai
authors.affiliation: Department of Gastroenterology, Onomichi Municipal Hospital, Onomichi, 722-8503, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Miyabe
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Takata
authors.affiliation: Department of Endoscopy, Okayama University Hospital, Okayama, 700-8558, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawano
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002432:Cecum / Q000473:pathology*; D003106:Colon / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019310:Pseudolymphoma / Q000150:complications* / Q000473:pathology*; D012130:Respiratory Hypersensitivity / Q000150:complications*; D012189:Retrospective Studies
keywords: Colonoscopy; Colorectal disease; Food hypersensitivity; Lymphoid hyperplasia; Seasonal allergic rhinitis