title: [A Case of Corneal Injury due to Herbicide Containing Paraquat: Effectiveness of 2% Rebamipide Eye Drops].
abstract: BACKGROUND
  Herbicides containing paraquat are widely used and have occasionally been causing ocular damage. The initial ocular injury caused by paraquat tends to worsen within a few days to 1 week. The toxicity of paraquat is based on the oxidative stress induced by reactive oxygen species.
  
  
  METHODS
  An 82-year-old woman who had been exposed to herbicide containing paraquat in her left eye presented at Koumeikan Eye Clinic 2 days after the incident. Moderate corneal erosion was diagnosed and treated with ordinary medication, but the corneal lesion worsened. After administration of topical 2% rebamipide eye drops, the corneal lesion resolved rapidly.
  
  
  CONCLUSIONS
  Because of its role as a radical scavenger, rebamipide has great potential for treatment of corneal injuries caused by herbicides such as paraquat.
authors.forename: Makoto
authors.initials: M
authors.lastname: Uno
mesh_terms: D000369:Aged, 80 and over; D000409:Alanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003316:Corneal Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D006801:Humans; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D018384:Oxidative Stress; D010269:Paraquat / Q000633:toxicity*; D015363:Quinolones / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D006540:Herbicides; D009883:Ophthalmic Solutions; D015363:Quinolones; C052785:rebamipide; D000409:Alanine; D010269:Paraquat