title: Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder.
abstract: Obsessive-compulsive disorder (OCD) is one of the most common mental health disorders, characterized by obsessive thoughts and/or compulsive behaviors, which may involve specific disorders in cognition and/or information processing. Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function as they are easily measured and noninvasive. In the present study, 20 drug-naïve pediatric patients with OCD were compared with 20 healthy control participants who were age- and sex-matched to perform the ERP. Based on the guidelines for evoked potential measurement, the P300 and mismatch negativity (MMN) were obtained by auditory odd-ball tasks. We found that the amplitudes of the P300 components in the Fz, Cz, Pz, C3, and C4 regions were significantly smaller in the OCD group compared with the control group. There were no between-group differences in P300 latency, MMN amplitude, or MMN latency. Moreover, we found significant correlations between scores on the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) and P300 amplitudes at Cz, Pz, and C3. The present study is the first to report smaller P300s and the associations between P300 abnormalities and CY-BOCS scores.
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamuro
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan. Electronic address: toyosaku@naramed-u.ac.jp.
authors.forename: Toyosaku
authors.initials: T
authors.lastname: Ota
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakanishi
authors.affiliation: Department of Psychiatry, Tenri Hospital, Tenri, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Matsuura
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Okazaki
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kishimoto
authors.affiliation: Department of Psychiatry, Akithukounoike Hospital, Gose, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Education, Nara University of Education, Nara, Japan.
authors.forename: Hidemi
authors.initials: H
authors.lastname: Iwasaka
authors.affiliation: Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Junzo
authors.initials: J
authors.lastname: Iida
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D002648:Child; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008606:Mental Processes / Q000502:physiology*; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D013647:Task Performance and Analysis
keywords: Event related potentials; Mismatch negativity; Obsessive-compulsive disorder; P300