title: Dual-function fluorescent probe for cancer imaging and therapy.
abstract: To date, several fluorescent probes modified by a single targeting agent have been explored. However, studies on the preparation of dual-function quantum dot (QD) fluorescent probes with dual-targeting action and a therapeutic effect are rare. Here, a dual-targeting CdTe/CdS QD fluorescent probe with a bovine serum albumin-glycyrrhetinic acid conjugate and arginine-glycine-aspartic acid was successfully prepared that could induce the apoptosis of liver cancer cells and showed enhanced targeting in in vitro cell imaging. Therefore, the as-prepared fluorescent probe in this work is an efficient diagnostic tool for the simultaneous detection of liver cancer and breast cancer cells.
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
authors.forename: Hongjing
authors.initials: H
authors.lastname: Cui
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Song
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.|Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Zhong
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D019187:Cadmium Compounds / Q000737:chemistry; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D006034:Glycyrrhetinic Acid / Q000737:chemistry; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D009842:Oligopeptides / Q000737:chemistry; D045663:Quantum Dots; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013691:Tellurium / Q000737:chemistry
chemical_list: D019187:Cadmium Compounds; D005456:Fluorescent Dyes; D009842:Oligopeptides; D012710:Serum Albumin, Bovine; C047981:arginyl-glycyl-aspartic acid; D013691:Tellurium; D006034:Glycyrrhetinic Acid; C028337:cadmium telluride
keywords: cancer imaging; detection; dual-function; near-infrared quantum dots; targeting