title: Nutritional status and feeding-tube placement in patients with locally advanced hypopharyngeal cancer included in an induction chemotherapy-based larynx preservation program.
abstract: The objective of the study is to evaluate the nutritional status and determine its impact on clinical outcomes in patients with locally advanced hypopharyngeal cancer included in an induction chemotherapy (ICT)-based larynx preservation program without prophylactic feeding-tube placement. All patients with locally advanced (T3/4, N0-3, M0) hypopharyngeal squamous cell carcinoma, technically suitable for total pharyngolaryngectomy, treated by docetaxel, cisplatin and 5-fluorouracil (TPF)-ICT for larynx preservation at our institution between 2004 and 2013, were included in this retrospective study. Patients' nutritional status was closely monitored. Enteral nutrition was used if and when a patient was unable to sustain per-oral nutrition and hydration. The impact of nutritional status on clinical outcomes was investigated in univariate and multivariate analysis. A total of 53 patients (42 men and 11 women, mean age = 58.6 ± 8.2 years) were included in this study. Six (11.3 %) patients had lost more than 10 % of their usual body weight before therapy. Compared with patients' usual weight, the mean maximum patient weight loss during therapeutic management was 8.7 ± 4.5 kg. Enteral nutrition was required in 17 patients (32 %). We found no influence of the tested nutritional status-related factors on response to ICT, toxicity of ICT, overall, cause-specific and recurrence-free survival, and on post-therapeutic swallowing outcome. Maximum weight loss was significantly associated with a higher risk of enteral tube feeding during therapy (p = 0.03) and of complications (grade ≥3, p = 0.006) during RT. Without prophylactic feeding-tube placement, approximately one-third of the patients required enteral nutrition. There was no significant impact of nutritional status on oncologic or functional outcomes.
authors.affiliation: Institut Universitaire de la Face et du Cou, 31 avenue de Valombrose, 06103, Nice, France. alexandre.bozec@nice.unicancer.fr.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bozec
authors.affiliation: Department of Radiotherapy, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Karen
authors.initials: K
authors.lastname: Benezery
authors.affiliation: Department of Statistics, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Chamorey
authors.affiliation: Department of Statistics, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Ettaiche
authors.affiliation: Institut Universitaire de la Face et du Cou, 31 avenue de Valombrose, 06103, Nice, France.
authors.forename: Clair
authors.initials: C
authors.lastname: Vandersteen
authors.affiliation: Institut Universitaire de la Face et du Cou, 31 avenue de Valombrose, 06103, Nice, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Dassonville
authors.affiliation: Institut Universitaire de la Face et du Cou, 31 avenue de Valombrose, 06103, Nice, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Poissonnet
authors.affiliation: Institut Universitaire de la Face et du Cou, 31 avenue de Valombrose, 06103, Nice, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Riss
authors.affiliation: Department of Radiotherapy, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Hannoun-Lévi
authors.affiliation: Department of Radiotherapy, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Chand
authors.affiliation: Department of Radiotherapy, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Axel
authors.initials: A
authors.lastname: Leysalle
authors.affiliation: Department of Medical Oncology, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Esma
authors.initials: E
authors.lastname: Saada
authors.affiliation: Department of Pathology, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Sudaka
authors.affiliation: Department of Pathology, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Haudebourg
authors.affiliation: Department of Nutrition, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Hebert
authors.affiliation: Department of Nutrition, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Marie-Noelle
authors.initials: MN
authors.lastname: Falewee
authors.affiliation: Institut Universitaire de la Face et du Cou, 31 avenue de Valombrose, 06103, Nice, France.
authors.forename: François
authors.initials: F
authors.lastname: Demard
authors.affiliation: Institut Universitaire de la Face et du Cou, 31 avenue de Valombrose, 06103, Nice, France.
authors.forename: José
authors.initials: J
authors.lastname: Santini
authors.affiliation: Department of Medical Oncology, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06103, Nice, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Peyrade
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D002945:Cisplatin / Q000627:therapeutic use; D000077143:Docetaxel; D004750:Enteral Nutrition; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D060828:Induction Chemotherapy; D007441:Intubation, Gastrointestinal; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D059351:Organ Sparing Treatments; D012189:Retrospective Studies; D043823:Taxoids / Q000627:therapeutic use
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil
keywords: Cancer; Enteral feeding tube; Functional outcome; Hypopharynx; Nutrition; Treatment