title: Autoimmune disease and vaccination: impact on infectious disease prevention and a look at future applications.
abstract: Vaccines hold promise both for the prevention of infections and as potential immunologic therapy for patients with autoimmune disease (AD). These patients are at high risk for both common and opportunistic infections, but this risk can be significantly reduced and even obviated with the use of recommended available vaccines. Unfortunately, patients with ADs are not routinely offered or provided indicated vaccinations and have higher rates of complications from vaccine-preventable illnesses than patients without ADs. In addition, vaccine therapy is currently under study for the treatment of autoimmune disorders, with early studies demonstrating immunomodulatory effects that may counter undesired immune activation and alleviate disease activity.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Henry Ford Hospital System, Detroit, Mich. Electronic address: jmckinn3@hfhs.org.
authors.forename: John E
authors.initials: JE
authors.lastname: McKinnon
authors.affiliation: Department of Medicine, Division of Rheumatology, Henry Ford Hospital System, Detroit, Mich.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Maksimowicz-McKinnon
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy*; D003141:Communicable Diseases / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D016867:Immunocompromised Host; D007167:Immunotherapy / Q000379:methods*; D014611:Vaccination / Q000009:adverse effects / Q000379:methods*