title: [Evaluation of the automated coagulation analyser Sysmex(®) CS-5100 (Siemens)].
abstract: The Sysmex® CS-5100 is a fully automated multiparameter hemostasis analyzer equipped with a photo-optical clot detection unit, a cap-piercing system and a pre-analytical check screens for interfering substances such as bilirubin, lipids and haemolysis (HIL system). It is designed to perform coagulation tests as well as coagulometric, chromogenic and immunologic assays. The aim of the present study was to evaluate its performance. The intra-assay and inter-assay coefficients of variation (CV) were below 6% for most parameters both in the normal and in the pathological range (exceptions: intra-assay for severe factor VIII deficiency (CV = 7.4%) and for vWFRco (CV = 7.3% and 7.7%); and inter-assay for anti-Xa activity (CV = 8.8%) and vWFRco (9.3% and 11.1%). The measured lower limits of linearity for factor VIII and factor V were satisfactory. No sample or reagent carryover was detected in the conditions of the study. Our results demonstrated that using the Sysmex® CS-5100 analyzer, routine coagulation testing can be performed with satisfactory precision. This automate has the advantage of being connectable to an automation chain.
authors.affiliation: UF d'hémostase, Service d'hématologie biologique, Hôpital de la Pitié-Salpêtrière-CFX, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Martin-Toutain
authors.affiliation: UF d'hémostase, Service d'hématologie biologique, Hôpital de la Pitié-Salpêtrière-CFX, Paris, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Jobic
authors.affiliation: UF d'hémostase, Service d'hématologie biologique, Hôpital de la Pitié-Salpêtrière-CFX, Paris, France.
authors.forename: Tessy
authors.initials: T
authors.lastname: Mancic
authors.affiliation: UF d'hémostase, Service d'hématologie biologique, Hôpital de la Pitié-Salpêtrière-CFX, Paris, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Brissard
authors.affiliation: UF d'hémostase, Service d'hématologie biologique, Hôpital de la Pitié-Salpêtrière-CFX, Paris, France.
authors.forename: Annick
authors.initials: A
authors.lastname: Ankri
mesh_terms: D001780:Blood Coagulation Tests / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans
keywords: Sysmex® CS-5100; evaluation; hemostasis analyzer