title: Telomere length in early childhood: Early life risk factors and association with carotid intima-media thickness in later childhood.
abstract: Reduced telomere length is a measure of biological aging that is predictive of cardiac events in adults, and has been mechanistically implicated in the onset and progression of atherosclerosis. We sought to describe the early life factors associated with leukocyte telomere length in early childhood, and to determine whether telomere length measured during early childhood is associated with arterial wall thickening later in childhood.
  
  
  
  A longitudinal birth cohort recruited antenatally in Sydney from 1997 to 1999.
  
  
  
  Leukocyte telomere length was measured in 331 children at age 3.6 years (SD 1.0); of whom 268 children without diabetes had carotid intima-media thickness assessed by ultrasound at age 8 years.
  
  
  
  Male sex, younger paternal age and higher maternal body mass index were associated with shorter telomere length in early childhood, which in turn was associated with greater carotid intima-media thickness at age 8 years (standardised β = -0.159, P = 0.01). There was a graded association across quartiles of telomere length (Ptrend = 0.001) with the highest odds of elevated intima-media thickness (>75th percentile) being in children with the shortest telomeres (odds ratio 4.00 (95% confidence interval 1.58 to 10.14) relative to those with the longest telomeres, P = 0.003). This association remained after adjustment for early life risk factors (Ptrend = 0.001).
  
  
  
  Reduced telomere length in early childhood is independently associated with arterial wall thickness in later childhood, suggesting that reduced telomere length during early childhood may be a marker of vascular disease risk.
authors.affiliation: Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney, Australia Sydney Medical School, University of Sydney, Australia michael.skilton@sydney.edu.au.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Skilton
authors.affiliation: Heart Research Institute, Sydney, Australia.
authors.forename: Shirley
authors.initials: S
authors.lastname: Nakhla
authors.affiliation: Sydney Medical School, University of Sydney, Australia The Heart Centre for Children, The Children's Hospital at Westmead, Australia.
authors.forename: Julian G
authors.initials: JG
authors.lastname: Ayer
authors.affiliation: Sydney Medical School, University of Sydney, Australia.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Harmer
authors.affiliation: Woolcock Institute of Medical Research, University of Sydney, Australia Sydney Local Health District, Australia.
authors.forename: Brett G
authors.initials: BG
authors.lastname: Toelle
authors.affiliation: Sydney Medical School, University of Sydney, Australia Sydney School of Public Health, and Menzies Centre for Health Policy, University of Sydney, Australia.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Leeder
authors.affiliation: School of Science and Health, University of Western Sydney, Australia.
authors.forename: Graham
authors.initials: G
authors.lastname: Jones
authors.affiliation: Woolcock Institute of Medical Research, University of Sydney, Australia South Western Sydney Clinical School, University of New South Wales, Australia.
authors.forename: Guy B
authors.initials: GB
authors.lastname: Marks
authors.affiliation: Sydney Medical School, University of Sydney, Australia Heart Research Institute, Sydney, Australia Sydney Local Health District, Australia.
authors.forename: David S
authors.initials: DS
authors.lastname: Celermajer
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D015992:Body Mass Index; D059168:Carotid Intima-Media Thickness; D002675:Child, Preschool; D004247:DNA / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009517:New South Wales / Q000453:epidemiology; D016017:Odds Ratio; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016615:Telomere; D013997:Time Factors
chemical_list: D005819:Genetic Markers; D004247:DNA
keywords: Telomere; atherosclerosis; childhood