title: RePORT International: Advancing Tuberculosis Biomarker Research Through Global Collaboration.
abstract: Progress in tuberculosis clinical research is hampered by a lack of reliable biomarkers that predict progression from latent to active tuberculosis, and subsequent cure, relapse, or failure. Regional Prospective Observational Research in Tuberculosis (RePORT) International represents a consortium of regional cohorts (RePORT India, RePORT Brazil, and RePORT Indonesia) that are linked through the implementation of a Common Protocol for data and specimen collection, and are poised to address this critical research need. Each RePORT network is designed to support local, in-country tuberculosis-specific data and specimen biorepositories, and associated research. Taken together, the expected results include greater global clinical research capacity in high-burden settings, and increased local access to quality data and specimens for members of each network and their domestic and international collaborators. Additional networks are expected to be added, helping to spur tuberculosis treatment and prevention research around the world.
authors.affiliation: Scientific Affairs, Global Health, Population and Nutrition, FHI 360 Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina.
authors.forename: Carol D
authors.initials: CD
authors.lastname: Hamilton
authors.affiliation: Department of Clinical Research, National Institute for Research in Tuberculosis, Chennai and Pune.
authors.forename: Soumya
authors.initials: S
authors.lastname: Swaminathan
authors.affiliation: Pulmonary Medicine, Christian Medical College, Vellore, India.
authors.forename: Devasahayam J
authors.initials: DJ
authors.lastname: Christopher
authors.affiliation: School of Medicine, Boston University, Massachusetts.
authors.forename: Jerrold
authors.initials: J
authors.lastname: Ellner
authors.affiliation: School of Medicine, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Amita
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Sterling
authors.affiliation: National Institute of Infectious Diseases Evandro Chagas-Fiocruz, Rio de Janeiro, Brazil.
authors.forename: Valeria
authors.initials: V
authors.lastname: Rolla
authors.affiliation: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
authors.forename: Sudha
authors.initials: S
authors.lastname: Srinivasan
authors.affiliation: Collaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health The National Institute of Research and Development, Indonesia Ministry of Health, Jakarta, Indonesia.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Karyana
authors.affiliation: Collaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
authors.forename: Sophia
authors.initials: S
authors.lastname: Siddiqui
authors.affiliation: Health Studies Sector, Westat, Rockville, Maryland.
authors.forename: Sonia K
authors.initials: SK
authors.lastname: Stoszek
authors.affiliation: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
authors.forename: Peter
authors.initials: P
authors.lastname: Kim
mesh_terms: D018070:Biological Specimen Banks; D015415:Biomarkers / Q000032:analysis*; D035843:Biomedical Research; D001938:Brazil; D006801:Humans; D007194:India; D007214:Indonesia; D007391:International Cooperation; D011446:Prospective Studies; D013048:Specimen Handling; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D015415:Biomarkers
keywords: biological markers; biological specimen banks; prospective studies; specimen handling; tuberculosis