title: Human induced pluripotent stem cells in Parkinson's disease: A novel cell source of cell therapy and disease modeling.
abstract: Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) are two novel cell sources for studying neurodegenerative diseases. Dopaminergic neurons derived from hiPSCs/hESCs have been implicated to be very useful in Parkinson's disease (PD) research, including cell replacement therapy, disease modeling and drug screening. Recently, great efforts have been made to improve the application of hiPSCs/hESCs in PD research. Considerable advances have been made in recent years, including advanced reprogramming strategies without the use of viruses or using fewer transcriptional factors, optimized methods for generating highly homogeneous neural progenitors with a larger proportion of mature dopaminergic neurons and better survival and integration after transplantation. Here we outline the progress that has been made in these aspects in recent years, particularly during the last year, and also discuss existing issues that need to be addressed.
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Rui Jin Er Road, Shanghai 200025, China; Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Rui Jin Er Road, Shanghai 200025, China. Electronic address: chen_sd@medmail.com.cn.
authors.forename: Shengdi
authors.initials: S
authors.lastname: Chen
authors.affiliation: Institute of Neuroscience, College of Life and Health Sciences, Northeastern University, Shenyang, China; Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84 Lund, Sweden. Electronic address: jia-yi.li@med.lu.se.
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Li
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000187:drug effects / Q000502:physiology* / Q000637:transplantation*; D010300:Parkinson Disease / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D000978:Antiparkinson Agents
keywords: Disease modeling; Dopaminergic differentiation; Induced pluripotent stem cells; Neural transplantation; Parkinson's disease; Reprogramming