title: Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive-compulsive disorder.
abstract: OBJECTIVE
  There are limited published data about the role of oxidative stress in the pathophysiology of obsessive-compulsive disorder (OCD). In addition, oxidative stress and oxidative DNA damage have not been investigated together in OCD. In this study, we aimed to evaluate oxidative stress and oxidative DNA damage in patients with OCD.
  
  
  METHODS
  Forty-two patients with OCD who were diagnosed in the Psychiatry Clinic of Gaziantep University and 38 healthy volunteers were enrolled in the study. Serum 8-hydroxideoxiguanosine (8-OHdG), total antioxidant status, total oxidant status evaluation and oxidative stress index calculation were conducted in Gaziantep University Biochemical Laboratory.
  
  
  RESULTS
  There were no significant differences in the total antioxidant status, total oxidant status and oxidative stress index levels between the patients and control group. However, 8-OHdG levels were significantly higher in OCD patients than controls (P = 0.022). In addition, 8-OHdG levels were significantly lower in patients who took treatment than in patients who were newly diagnosed (P = 0.016).
  
  
  CONCLUSIONS
  In our study, we found that oxidative DNA damage increased in OCD patients even though oxidative stress was normal. In addition, DNA damage was lower in patients who were treated compared to those without treatment.
authors.affiliation: Clinic of Psychiatry, Dr. Ersin Arslan State Hospital, Gaziantep, Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Alici
authors.affiliation: Department of Psychiatry, Gaziantep University, Gaziantep, Turkey.
authors.forename: Feridun
authors.initials: F
authors.lastname: Bulbul
authors.affiliation: Department of Psychiatry, Gaziantep University, Gaziantep, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Virit
authors.affiliation: Department of Psychiatry, Gaziantep University, Gaziantep, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Unal
authors.affiliation: Department of Psychiatry, Gaziantep University, Gaziantep, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Altindag
authors.affiliation: Department of Psychiatry, Gaziantep University, Gaziantep, Turkey.
authors.forename: Gokay
authors.initials: G
authors.lastname: Alpak
authors.affiliation: Clinic of Cardiology, 25 Aralik State Hospital, Gaziantep, Turkey.
authors.forename: Hayri
authors.initials: H
authors.lastname: Alici
authors.affiliation: Clinic of Psychiatry, Bitlis State Hospital, Bitlis, Turkey.
authors.forename: Berna
authors.initials: B
authors.lastname: Ermis
authors.affiliation: Department of Biochemistry, Gaziantep University, Gaziantep, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Orkmez
authors.affiliation: Department of Biochemistry, Gaziantep University, Gaziantep, Turkey.
authors.forename: Seyithan
authors.initials: S
authors.lastname: Taysi
authors.affiliation: Department of Psychiatry, Gaziantep University, Gaziantep, Turkey.
authors.forename: Haluk
authors.initials: H
authors.lastname: Savas
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D055815:Young Adult
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
keywords: 8-hydroxideoxiguanosine; DNA damage; obsessive-compulsive disorder; oxidative stress; treatment