title: Natural compounds with Wnt signal modulating activity.
abstract: Covering: up to 2015 The Wnt signalling pathway is essential in many biological processes. The Wnt signal is associated with several diseases, particularly cancer and neurodegenerative diseases. Recently, high-throughput screening systems have been developed to rapidly identify compounds, including natural compounds, that target the Wnt signal. Some studies on natural modulators of the Wnt signal have also suggested their possible target. This review highlights some important natural compounds reported to regulate Wnt activity and describes their possible mechanism of action.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. mish@chiba-u.jp.
authors.forename: Rolly G
authors.initials: RG
authors.lastname: Fuentes
authors.forename: Midori A
authors.initials: MA
authors.lastname: Arai
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D000818:Animals; D001688:Biological Products / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms; D019636:Neurodegenerative Diseases; D015398:Signal Transduction; D051153:Wnt Proteins / Q000187:drug effects / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D015027:Zebrafish
chemical_list: D001688:Biological Products; D051153:Wnt Proteins