title: Hepatitis B virus surface antibody titers in babies administered hepatitis B immune globulin both intravenously and intramuscularly after birth.
abstract: OBJECTIVE
  High rates of vertical transmission of hepatitis B virus (HBV) infection from carrier mothers to their babies are observed in hepatitis B e antigen (HBeAg)-positive mothers under the existing protocol. The current status suggests that the existing protocol may be insufficient for the prevention of mother-to-child transmission (MTCT) in HBeAg-positive mothers. To achieve complete prevention of HBV vertical transmission, we designed a protocol implementing intravenous administration along with ordinary intramuscular administration of HBV immune globulin (HBIG) to the baby after birth.
  
  
  METHODS
  We compared the HBV surface antibody (HBsAb) titer in babies who were simultaneously administered HBIG both intravenously and intramuscularly after birth with that in babies who received HBIG only intramuscularly.
  
  
  RESULTS
  The HBsAb titer rose rapidly after administration in the combined administration group, and the elevated titer was maintained for approximately 2 months. Although the antibody titer at the peak was nearly 6 times greater in the combined administration group than in the intramuscular administration group, the combined administration of HBIG did not have any effect on total IgG antibody levels in the bloodstream.
  
  
  CONCLUSIONS
  The combined protocol was demonstrated to be safe and superior to the protocol of only intramuscular HBIG administration with respect to rapid elevation of HBsAb in the bloodstream. It could be an effective method for the prevention of MTCT in HBeAg-positive mothers.
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan and.
authors.forename: Masachi
authors.initials: M
authors.lastname: Hanaoka
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan and.
authors.forename: Michi
authors.initials: M
authors.lastname: Hisano
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan and.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Hama
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan and.
authors.forename: Keiko
authors.initials: K
authors.lastname: Tsukamoto
authors.affiliation: b Division of Hepatology , National Center for Child Health and Development , Tokyo , Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Ito
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan and.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Ito
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan and.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
authors.affiliation: b Division of Hepatology , National Center for Child Health and Development , Tokyo , Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Matsui
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan and.
authors.forename: Koushi
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D007273:Injections, Intramuscular; D008297:Male; D011247:Pregnancy
chemical_list: D006514:Hepatitis B Surface Antigens; D016756:Immunoglobulins, Intravenous
keywords: HBV immune globulin; HBV surface antibody; hepatitis B virus; mother-to-child transmission