title: Short-term ibuprofen treatment and pulmonary function in children with asthma.
abstract: OBJECTIVE
  To investigate the association between ibuprofen use and pulmonary function in children with Asthma.
  
  
  METHODS
  Ninety 9- to 10-year-old children were classified into 3 groups: Study group, mild to moderate stable asthmatic children with self-reported aspirin allergy and no history of anaphylaxis; Allergy control group: atopic children (allergic rhinitis/atopic dermatitis); Healthy control group: non-atopic healthy children. None of the participants in the atopic and healthy control groups had a history of aspirin allergy. All received ibuprofen 4 times a day for 3 consecutive days. Forced expiratory volume in the first second (FeV1) and fractional exhaled nitric oxide (FeNO) measurements were performed before and after ingestion of ibuprofen daily for 3 days.
  
  
  RESULTS
  In the study group, a decrease in FeV1 and increase in FeNO levels were observed after taking ibuprofen for 2 days. The atopic control group showed only an increase in FeNO but not FEV1. In the healthy control group, both FeV1 and FeNO were unchanged from baseline.
  
  
  CONCLUSIONS
  The results showed that cross-reactive non-steroidal anti-inflammatory drug hypersensitivity may exist between ibuprofen and aspirin. This raises the possibility that asthma exacerbation could be mediated by ibuprofen ingestion.
authors.affiliation: Department of Pediatrics, Taipei City Hospital-Renai Branch, Taiwan. Correspondence to: Dr Kong-Sang Wan, Department of Pediatrics, Taipei City Hospital-Renai Branch, No.10, Sec.4, Renai Road, Da An District, Taipei City 10629, Taiwan. gwan1998@gmail.com.
authors.forename: Yu-Mao
authors.initials: YM
authors.lastname: Su
authors.forename: Che-Sheng
authors.initials: CS
authors.lastname: Huang
authors.forename: Kong-Sang
authors.initials: KS
authors.lastname: Wan
mesh_terms: D001249:Asthma / Q000378:metabolism*; D001944:Breath Tests; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009569:Nitric Oxide / Q000032:analysis*
chemical_list: D009569:Nitric Oxide; D007052:Ibuprofen