title: Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed C-H Functionalization and Spiroannulation.
abstract: Chiral cyclopentadienyl rhodium complexes promote highly enantioselective enol-directed C(sp(2))-H functionalization and oxidative annulation with alkynes to give spiroindenes containing all-carbon quaternary stereocenters. High selectivity between two possible directing groups, as well as control of the direction of rotation in the isomerization of an O-bound rhodium enolate into the C-bound isomer, appear to be critical for high enantiomeric excesses.
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD (UK) http://www.nottingham.ac.uk/∼pczhl.
authors.forename: Suresh
authors.initials: S
authors.lastname: Reddy Chidipudi
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD (UK) http://www.nottingham.ac.uk/∼pczhl.
authors.forename: David J
authors.initials: DJ
authors.lastname: Burns
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD (UK) http://www.nottingham.ac.uk/∼pczhl.
authors.forename: Imtiaz
authors.initials: I
authors.lastname: Khan
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD (UK) http://www.nottingham.ac.uk/∼pczhl. hon.lam@nottingham.ac.uk.
authors.forename: Hon Wai
authors.initials: HW
authors.lastname: Lam
keywords: C-H activation; alkynes; catalysis; enantioselective; rhodium