title: NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia.
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok.
authors.forename: Kanhatai
authors.initials: K
authors.lastname: Chiengthong
authors.affiliation: Central Laboratory, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok.
authors.forename: Chupong
authors.initials: C
authors.lastname: Ittiwut
authors.affiliation: Central Laboratory, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok.
authors.forename: Sasipa
authors.initials: S
authors.lastname: Muensri
authors.affiliation: Department of Biostatistics, HIV Netherlands Australia Thailand (HIV-NAT) Research Collaboration, Thai Red Cross AIDS Research Center, Bangkok.
authors.forename: Jiratchaya
authors.initials: J
authors.lastname: Sophonphan
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok.
authors.forename: Darintr
authors.initials: D
authors.lastname: Sosothikul
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok.
authors.forename: Panya
authors.initials: P
authors.lastname: Seksan
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok koramiz@yahoo.com.
authors.forename: Koramit
authors.initials: K
authors.lastname: Suppipat
authors.affiliation: Center of Excellence for Medical Genetics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok Excellence Center for Medical Genetics, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand.
authors.forename: Kanya
authors.initials: K
authors.lastname: Suphapeetiporn
authors.affiliation: Center of Excellence for Medical Genetics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok Excellence Center for Medical Genetics, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand.
authors.forename: Vorasuk
authors.initials: V
authors.lastname: Shotelersuk
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage*; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics*; D011755:Pyrophosphatases / Q000235:genetics*; D012307:Risk Factors; D000096964:Nudix Hydrolases
chemical_list: D015122:Mercaptopurine; D011755:Pyrophosphatases; C543721:NUDT15 protein, human; D000096964:Nudix Hydrolases
keywords: NUDT15; acute lymphoblastic leukemia; myelosuppression; pharmacogenetics