title: Present and future challenges of induced pluripotent stem cells.
abstract: Growing old is our destiny. However, the mature differentiated cells making up our body can be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate into all cell types by enforced expression of defined transcription factors. The discovery of this induced pluripotent stem cell (iPSC) technology has opened up unprecedented opportunities in regenerative medicine, disease modelling and drug discovery. In this review, we introduce the applications and future perspectives of human iPSCs and we also show how iPSC technology has evolved along the way.
authors.affiliation: Department Biology II, Ludwig Maximilians University Munich, 82152 Martinsried Planegg, Germany.
authors.forename: Mari
authors.initials: M
authors.lastname: Ohnuki
authors.affiliation: Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA takahash@cira.kyoto-u.ac.jp.
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D017690:Cell Transplantation; D064987:Cell- and Tissue-Based Therapy; D065150:Cellular Reprogramming; D004353:Drug Evaluation, Preclinical; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation; D008954:Models, Biological; D044968:Regenerative Medicine
keywords: cancer; epigenetics; induced pluripotent stem cells; regenerative medicine; reprogramming