title: Progress of iron-chelating therapy for iron overload in patients after bone marrow transplantation.
abstract: Bone marrow transplantation (BMT) is commonly used to treat hematopoietic system malignant diseases. Iron overload, which is one of the most common complications in patients undergoing BMT, has a negative impact on survival after allogeneic transplantation. Better understanding of molecular mechanisms of iron overload can improve the treatment regime and improve the efficiency for iron-chelating therapy. In this review, we summarize the mechanisms of iron overload in various conditions and the progression of iron-chelating strategies in patients undergoing BMT. This review will provide insights into the prevention and treatment of patients with iron overload after BMT.
authors.affiliation: School of Biotechnology, Jiangnan University, Wuxi 214122, China.
authors.forename: Shi-wei
authors.initials: SW
authors.lastname: Li
authors.affiliation: Wuxi Medical School, Jiangnan University, Wuxi 214122, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Biotechnology, Jiangnan University, Wuxi 214122, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Guan
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D015316:Genetic Therapy; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D019190:Iron Overload / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics
chemical_list: D007502:Iron Chelating Agents