title: Phosphoinositides: Important lipids in the coordination of cell dynamics.
abstract: By interacting specifically with proteins, phosphoinositides organize the spatiotemporal formation of protein complexes involved in the control of intracellular signaling, vesicular trafficking and cytoskeleton dynamics. A set of specific kinases and phosphatases ensures the production, degradation and inter-conversion of phosphoinositides to achieve a high level of precision in the regulation of cellular dynamics coordinated by these lipids. The direct involvement of these enzymes in cancer, genetic or infectious diseases, and the recent arrival of inhibitors targeting specific phosphoinositide kinases in clinic, emphasize the importance of these lipids and their metabolism in the biomedical field.
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France. Electronic address: julien.viaud@inserm.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Viaud
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Rana
authors.initials: R
authors.lastname: Mansour
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Adrien
authors.initials: A
authors.lastname: Antkowiak
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Abdulrahman
authors.initials: A
authors.lastname: Mujalli
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Colin
authors.initials: C
authors.lastname: Valet
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Gaëtan
authors.initials: G
authors.lastname: Chicanne
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Xuereb
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Anne-Dominique
authors.initials: AD
authors.lastname: Terrisse
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Sonia
authors.initials: S
authors.lastname: Séverin
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Gratacap
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Gaits-Iacovoni
authors.affiliation: INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III Paul Sabatier, 1 Avenue Jean Poulhès, BP84225, 31432 Toulouse Cedex 04, France; Centre Hospitalier Universitaire de Toulouse, Laboratoire d'Hématologie, 31059 Toulouse Cedex 03, France. Electronic address: bernard.payrastre@inserm.fr.
authors.forename: Bernard
authors.initials: B
authors.lastname: Payrastre
mesh_terms: D019870:1-Phosphatidylinositol 4-Kinase / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000235:genetics / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D010716:Phosphatidylinositols / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009363:Neoplasm Proteins; D010716:Phosphatidylinositols; D019870:1-Phosphatidylinositol 4-Kinase
keywords: Cell signaling; Lipids; PI3K; Pathologies; Phosphoinositide-metabolizing enzymes; Phosphoinositides