title: Comparative evaluation of cost effectiveness and recovery profile between propofol and sevoflurane in laparoscopic cholecystectomy.
abstract: BACKGROUND
  Anesthetic agents should be chosen not only on the basis of safety-efficacy profile, but also on the economic aspect. Propofol and sevoflurane are commonly utilized anesthetic agent for general anesthesia.
  
  
  OBJECTIVE
  The present study was designated to compare cost-effectiveness and recovery profile between propofol and sevoflurane for induction, maintenance or both.
  
  
  METHODS
  Randomized controlled, participant and data operator blinded trial.
  
  
  METHODS
  Ninety patients undergoing laparoscopic cholecystectomy were randomized into three equal groups to receive: Group P to receive injection propofol for both induction and maintenance; Group PS to receive injection propofol for induction and sevoflurane for maintenance; and Group S to receive sevoflurane for both induction and maintenance of general anesthesia, respectively. Cost analysis, hemodynamic parameter, and recovery profile were compared between these groups.
  
  
  METHODS
  One-way analysis of variance test or Fisher's exact test/Chi-square test whichever appropriate.
  
  
  RESULTS
  Total cost of anesthesia was highest in Group P and lowest in Group S. Mean time to extubation and time to follow verbal commands was lowest in Group S than Group P or Group P/S. Hemodynamic parameter was more stable in Group S.
  
  
  CONCLUSIONS
  We conclude that sevoflurane appears to be better anesthetic agents in terms of cost-effectiveness and recovery profile.
authors.affiliation: Department of Anaesthesiology and Intensive Care, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
authors.forename: Yashpal
authors.initials: Y
authors.lastname: Singh
authors.affiliation: Department of Anaesthesiology and Intensive Care, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
authors.forename: Anil P
authors.initials: AP
authors.lastname: Singh
authors.affiliation: Department of Anaesthesiology and Intensive Care, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Jain
authors.affiliation: Department of Anaesthesiology and Intensive Care, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
authors.forename: Ghanshyam
authors.initials: G
authors.lastname: Yadav
authors.affiliation: Department of Anaesthesiology and Intensive Care, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Singh
keywords: Anesthesia; cost-effectiveness; propofol; sevoflurane