title: Malignant peripheral nerve sheath tumour in a sow.
abstract: Nodular lung lesions in swine are frequently due to abscesses or granulomatous pneumonia. Although tumours are rarely reported in modern pig farming, they should be considered as a differential diagnosis when nodular lung lesions are found. A first-parity sow exhibiting respiratory signs was euthanized. Several whitish firm nodules, not encapsulated, ranging in diameter from 0.5 to 5 cm were present in all lung lobes. Microscopically, the nodules were composed of dense neoplastic cells, mainly in Antoni types A and B patterns, infiltrative and with development of emboli. All neoplastic cells stained positively by immunohistochemistry for vimentin and S-100 protein, with variable immunostaining for glial fibrillary acidic protein and stained negative for cytokeratin. Based on the gross, histological and immunohistochemical features, the tumor was diagnosed as malignant peripheral nerve sheath tumour.
authors.affiliation: Department of Veterinary Clinic and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil. talitaresendevet@gmail.com.
authors.forename: Talita P
authors.initials: TP
authors.lastname: Resende
authors.affiliation: Department of Veterinary Clinic and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil. carlos.pereira@ufv.br.
authors.forename: Carlos E R
authors.initials: CE
authors.lastname: Pereira
authors.affiliation: Laboratório de Microbiologia Veterinária, Microvet, Rua Joaquim Lopes de Faria, 730, Viçosa, MG, 36570-000, Brazil. f.vannu@umn.edu.
authors.forename: Fabio A
authors.initials: FA
authors.lastname: Vannucci
authors.affiliation: , Praça Coronel Amantino 50, Piranga, MG, 36480-000, Brazil. fernandopiranga@hotmail.com.
authors.forename: Fernando S
authors.initials: FS
authors.lastname: Araujo
authors.affiliation: Laboratório de Microbiologia Veterinária, Microvet, Rua Joaquim Lopes de Faria, 730, Viçosa, MG, 36570-000, Brazil. jlucio@microvet.com.br.
authors.forename: José Lúcio
authors.initials: JL
authors.lastname: dos Santos
authors.affiliation: Department of General Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil. geovani.cassali@gmail.com.
authors.forename: Geovanni D
authors.initials: GD
authors.lastname: Cassali
authors.affiliation: Department of General Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil. karaujodamasceno@gmail.com.
authors.forename: Karine A
authors.initials: KA
authors.lastname: Damasceno
authors.affiliation: Department of Veterinary Clinic and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil. guedesufmg@gmail.com.
authors.forename: Roberto M C
authors.initials: RM
authors.lastname: Guedes
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D009442:Neurilemmoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D009418:S100 Proteins / Q000737:chemistry; D013552:Swine; D013553:Swine Diseases / Q000175:diagnosis* / Q000473:pathology; D014746:Vimentin / Q000737:chemistry
chemical_list: D009418:S100 Proteins; D014746:Vimentin