title: The pluripotent state in mouse and human.
abstract: In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture equivalent of the late epiblast in the pre-implantation embryo, with which they share a unique defining set of features. Recent studies have focused on the identification and propagation of a similar cell state in human. Although the capture of an exact human equivalent of the mouse naïve PSC remains an elusive goal, comparative studies spurred on by this quest are lighting the path to a deeper understanding of pluripotent state regulation in early mammalian development.
authors.affiliation: Centre for Eye Research Australia, University of Melbourne, and Royal Victorian Eye and Ear Hospital, Melbourne 3002, Victoria, Australia.
authors.forename: Kathryn C
authors.initials: KC
authors.lastname: Davidson
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Brisbane 4072, Australia Department of Anatomy and Neuroscience, University of Melbourne, Melbourne 3010, Victoria, Australia.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Mason
authors.affiliation: Department of Anatomy and Neuroscience, University of Melbourne, Melbourne 3010, Victoria, Australia The Florey Institute of Neuroscience and Mental Health and Walter Elisa Hall Institute of Medical Research, Parkville 3052, Victoria, Australia mpera@unimelb.edu.au.
authors.forename: Martin F
authors.initials: MF
authors.lastname: Pera
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000166:cytology / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D005855:Germ Layers / Q000166:cytology*; D006801:Humans; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology*; D013045:Species Specificity
keywords: Human; Mouse; Pluripotent state