title: Association of androgen receptor CAG repeat polymorphism and risk of epithelial ovarian cancer.
abstract: BACKGROUND
  Biological and epidemiologic evidence suggested that androgen and its receptor may play an important role in ovarian carcinogenesis. However, results of previous association studies about ovarian cancer and AR CAG repeat polymorphism were inconsistent. Furthermore, none of these studies were conducted in Asians.
  
  
  METHODS
  We evaluated the relationship between AR CAG repeat length and epithelial ovarian cancer (EOC) risk among a Chinese population including 1800 pathologically confirmed EOC patients and 1800 frequency matched controls.
  
  
  RESULTS
  Women with longer AR CAG repeats had a decreased EOC risk (OR=0.87 for per CAG_A increase, 95% CI: 0.81-0.95). Compared to those with shorter (<22) CAG_A repeat length, women with of longer (≥22) CAG_A repeats had a 34% decreased EOC risk (OR=0.66, 95% CI: 0.57-0.75). For CAG_S and CAG_L, the results remained consistent.
  
  
  CONCLUSIONS
  Our findings suggest that androgen signaling contributes to the development of ovarian cancer.
authors.affiliation: Dept. of Obstetrics and Gynecology, General Hospital of Jinan Military Command, Jinan, Shandong Province 250031, People's Republic of China. Electronic address: zhutysd@163.com.
authors.forename: Tongyu
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Dept. of Medical Information, General Hospital of Jinan Military Command, Jinan, Shandong Province 250031, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Dept. of Obstetrics and Gynecology, General Hospital of Jinan Military Command, Jinan, Shandong Province 250031, People's Republic of China.
authors.forename: Yudou
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Center for Reproductive Medicine, Dept. of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Dept. of Obstetrics and Gynecology, General Hospital of Jinan Military Command, Jinan, Shandong Province 250031, People's Republic of China.
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D000077216:Carcinoma, Ovarian Epithelial; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011944:Receptors, Androgen / Q000235:genetics*; D019680:Trinucleotide Repeat Expansion
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen
keywords: AR; CAG; Ovarian cancer; Polymorphism; Repeat