title: Recent advances and opportunities in synthetic logic gates engineering in living cells.
abstract: Recently, a number of synthetic biologic gates including AND, OR, NOR, NOT, XOR and NAND have been engineered and characterized in a wide range of hosts. The hope in the emerging synthetic biology community is to construct an inventory of well-characterized parts and install distinct gene and circuit behaviours that are externally controllable. Though the field is still growing and major successes are yet to emerge, the payoffs are predicted to be significant. In this review, we highlight specific examples of logic gates engineering with applications towards fundamental understanding of network complexity and generating a novel socially useful applications.
authors.affiliation: Department of Biotechnology, Invertis University, Bareilly- Lucknow National Highway-24, Bareilly, 243123 India ; Synthetic Biology Laboratory, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, Ulju-gun, Ulsan, 689-798 Republic of Korea.
authors.forename: Vijai
authors.initials: V
authors.lastname: Singh
keywords: Gene networks; Gene regulation; Logic gate; Synthetic biology; Therapy