title: Hepatic steatosis is associated with higher incidence of liver metastasis in patients with metastatic breast cancer; an observational clinical study.
abstract: OBJECTIVE
  To investigate the relationship between hepatic steatosis (HS) (at the time of diagnosis) and hepatic metastasis (at the time of diagnosis and follow-up) in metastatic breast cancer (BC) patients by using computed tomography (CT).
  
  
  METHODS
  A total of 107 metastatic BC patients who had an abdominal CT were retrospectively enrolled in this study. Patients without HS (N=79) were regarded as the control group and those with HS constituted the HS study group (N-28).
  
  
  RESULTS
  Hepatic metastases at diagnosis and during follow-up were more common in patients with HS (p=0.018 and p=0.041, respectively) and in the premenopausal group (p<0.001 and p=0.004, respectively), whereas they were similar in patients with and without HS in the postmenopausal group (p=0.655 and p=0.656, respectively). Overall survival rates were similar in patients with and without HS (p=0.606).
  
  
  CONCLUSIONS
  Hepatic metastases at diagnosis and during follow-up were more frequent in patients with HS, especially in premenopausal patients. Survival was similar in both groups.
authors.affiliation: 1Department of Medical Oncology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Ocak Duran
authors.forename: Afra
authors.initials: A
authors.lastname: Yildirim
authors.forename: Mevlude
authors.initials: M
authors.lastname: Inanc
authors.forename: Halit
authors.initials: H
authors.lastname: Karaca
authors.forename: Veli
authors.initials: V
authors.lastname: Berk
authors.forename: Oktay
authors.initials: O
authors.lastname: Bozkurt
authors.forename: Ersin
authors.initials: E
authors.lastname: Ozaslan
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ucar
authors.forename: Metin
authors.initials: M
authors.lastname: Ozkan
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D005234:Fatty Liver / Q000150:complications*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary*; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed