title: New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties.
abstract: The guanidine alkaloids, dihydropulchranin A (2), prepared from pulchranin A from the sponge Monanchora pulchra, and hexadecylguanidine (3), a synthetic analog of pulchranins, were studied for their TRPV channel-regulating activities. Compound 2 was active as an inhibitor of rTRPV1 and hTRPV3 receptors with EC50 values of 24.3 and 59.1 μM, respectively. Hexadecylguanidine (3) was not active against these receptors.
authors.forename: Ekaterina K
authors.initials: EK
authors.lastname: Ogurtsova
authors.forename: Tatyana N
authors.initials: TN
authors.lastname: Makarieva
authors.forename: Yuliya V
authors.initials: YV
authors.lastname: Korolkova
authors.forename: Yaroslav A
authors.initials: YA
authors.lastname: Andreev
authors.forename: Irina V
authors.initials: IV
authors.lastname: Mosharova
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Eugene V
authors.initials: EV
authors.lastname: Grishin
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Stonik
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D016466:CHO Cells; D003412:Cricetulus; D019791:Guanidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006146:Guanidines / Q000138:chemical synthesis*; D006801:Humans; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors*
chemical_list: D000470:Alkaloids; D006146:Guanidines; D050916:TRPV Cation Channels; C000602587:dihydropulchranin A; D019791:Guanidine