title: One-Pot Synthesis of Hydrophobically Modified Iminosugar C-Alkynylglycosides: Facile Synthesis of Polyhydroxy Tetrahydroindolizines.
abstract: A mild and efficient one-pot method has been developed for the stereoselective synthesis of structurally diverse novel iminosugar C-alkynylglycosides. The generality of this methodology has been demonstrated with a wide variety of amines and copper acetylides. This one-pot method has been exploited in the synthesis of new class of DNA cross-linking agents, polyhydroxy 1-vinyl-tetrahydroindolizine derivatives.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036 (India).
authors.forename: Soundararasu
authors.initials: S
authors.lastname: Senthilkumar
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036 (India).
authors.forename: Sure Siva
authors.initials: SS
authors.lastname: Prasad
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036 (India).
authors.forename: Amrita
authors.initials: A
authors.lastname: Das
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036 (India). sbhaskar@iitm.ac.in.
authors.forename: Sundarababu
authors.initials: S
authors.lastname: Baskaran
keywords: anticancer; glycosides; iminium ion; iminosugars; one-pot synthesis