title: Reticulate hyperpigmentation in systemic sclerosis: a case report and review of the literature.
abstract: BACKGROUND
  Systemic sclerosis is a systemic connective tissue disease with variable cutaneous presentations. Although pigmentary disturbances have been described in systemic sclerosis, a reticulate hyperpigmentation has only been reported in one case of systemic sclerosis to date.
  
  
  METHODS
  We describe a previously healthy 51-year-old Thai woman who presented with a reticulate hyperpigmentation affecting her trunk and extremities, together with sclerodactyly and proximal sclerosis, resulting in a new diagnosis of systemic sclerosis.
  
  
  CONCLUSIONS
  To date, the pathogenesis of reticulate hyperpigmentation in systemic sclerosis remains unclear. Increased melanin synthesis and altered thermoregulatory mechanism are proposed to be involved in the pathogenesis of this presentation. This case represents an unusual cutaneous feature of reticulate hyperpigmentation in the setting of systemic sclerosis.
authors.affiliation: Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd, Bangkoknoi, Bangkok, 10700, Thailand. drmch117@gmail.com.
authors.forename: Mati
authors.initials: M
authors.lastname: Chuamanochan
authors.affiliation: Department of Dermatology, University of Texas Health Science Center, 6655 Travis St., Suite 980, Houston, TX, 77030, USA. Ahaws@pathreflab.com.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Haws
authors.affiliation: Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd, Bangkoknoi, Bangkok, 10700, Thailand. penvadee.pat@mahidol.ac.th.
authors.forename: Penvadee
authors.initials: P
authors.lastname: Pattanaprichakul
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D003078:Colchicine / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006074:Gout Suppressants / Q000008:administration & dosage*; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology* / Q000628:therapy; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012867:Skin / Q000473:pathology*; D013785:Thailand; D016896:Treatment Outcome; D014467:Ultraviolet Therapy; D015431:Weight Loss
chemical_list: D000305:Adrenal Cortex Hormones; D006074:Gout Suppressants; D003078:Colchicine