title: [Application of a lipid emulsion for parenteral nutrition support in intensive care patients following gastrointestinal surgeries].
abstract: OBJECTIVE
  To investigate the effect of parenteral nutrition support with a lipid emulsion formulation (containing soybean oil, medium chain triglycerides, olive oil, and fish oil [SMOF]) in intensive care patients following major gastrointestinal surgeries.
  
  
  METHODS
  According to a randomized, prospective and case-controlled design, 72 intensive care patients following major gastrointestinal surgeries between January and December, 2014 were randomized equally into SMOF group and control group to receive parenteral nutrition support with SMOF and medium or long chain lipid emulsion, respectively. Before and at 4 and 9 days after commencement of parenteral nutrition support, the patients were examined for alanine aminotransferase (ALT), total bilirubin (TBIL), albumin (propagated), C-reactive protein (CRP), interleukin 6 (IL-6), and endotoxin levels. The patients' average length of stay in intensive care unit (ICU), the days of using antibiotics, and the incidence rate of postoperative complication were recorded.
  
  
  RESULTS
  On day 4 postoperatively, the levels of CRP and IL-6 were significantly lower in SMOF group than in the control group (t=2.669 and 2.676, respectively; P<0.05), and on day 9, the patients in SMOF group showed significantly lower levels of ALT, TBIL, CRP and IL-6 (t=2.487, 3.497, 3.762, 2.180, respectively; P<0.05) than the control group, but ALB and endotoxin levels remained comparable between the two groups. The average length of stay in ICU and the days of using antibiotics were significantly shorter in SMOF group than in the control group (t=2.94 and 2.17, respectively; P<0.05); SMOF group showed a lower incidence of postoperative infections than the control group, but the difference was not statistically significant (χ² =1.047, P>0.05).
  
  
  CONCLUSIONS
  For intensive care patients following major gastrointestinal surgeries, postoperative parenteral nutrition support with SMOF can effectively reduce the release of inflammatory mediators, protect important visceral functions, reduce postoperative complications, shorten the length of ICU stay, and improve the prognosis of the patients.
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.E-mail:Pandun0220@163.com.
authors.forename: Dun
authors.initials: D
authors.lastname: Pan
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Liangqing
authors.initials: L
authors.lastname: Li
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002097:C-Reactive Protein / Q000737:chemistry; D003422:Critical Care; D013505:Digestive System Surgical Procedures; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D005395:Fish Oils; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D000069463:Olive Oil; D010288:Parenteral Nutrition; D010938:Plant Oils; D011446:Prospective Studies; D013024:Soybean Oil; D014280:Triglycerides
chemical_list: D005217:Fat Emulsions, Intravenous; D005395:Fish Oils; D015850:Interleukin-6; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides; D013024:Soybean Oil; D002097:C-Reactive Protein; D000410:Alanine Transaminase; D001663:Bilirubin