title: Frontotemporal Lobar Degeneration with Accumulation of Argyrophilic Grains and Lewy Bodies: A Clinicopathological Report.
abstract: A clinicopathological investigation was conducted on a case of an 89-year-old man with a 10-year history of progressive dementia who also suffered strokes, apathy, aphasia, dysarthria, weakness of both legs, and walking difficulties. At autopsy, we found an obvious atrophy of the frontal and temporal cortex. Lewy bodies (LBs) could be seen in brain stem, amygdala, and neocortex. Argyrophilic grains were observed in hippocampus, entorhinal cortex, neocortex, amygdala, and pons, as well as neurofibrillary tangles in the entorhinal cortex and hippocampus. The case presented here is a rare case of frontotemporal lobar degeneration with accumulation of argyrophilic grains and Lewy bodies.
authors.affiliation: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Ming-wei
authors.initials: MW
authors.lastname: Zhu
authors.affiliation: German Center for Neurodegenerative Diseases, Munich, Germany.|Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany.|Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Arzberger
authors.affiliation: Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Lu-ning
authors.initials: LN
authors.lastname: Wang
mesh_terms: D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D057174:Frontotemporal Lobar Degeneration / Q000473:pathology*; D006801:Humans; D016631:Lewy Bodies / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology*
keywords: Argyrophilic grains; FTLD-tau; Lewy bodies; frontotemporal lobar degeneration