title: A method of extracting disease-related microRNAs through the propagation algorithm using the environmental factor based global miRNA network.
abstract: MicroRNAs (miRNA) are known to be involved in the development of various diseases. Hence various scientists in the field have been utilized computational analyses to determine the relationship between miRNA and diseases. However, the knowledge of miRNA and disease is still very limited. Therefore, we combined Environmental Factor (EF) data to a miRNA global network. Increasing research has shown that relationship between miRNAs and EFs play a significant role in classifying types of diseases. Environmental Factors consist of radiation, drugs, viruses, alcohol, cigarettes, and stress. Our global network considered all the interactions between every pair of miRNAs, which has led to precise analyses in comparison to local networks. As a result, our approaches' performance demonstrated its effectiveness in identifying disease-related miRNA and this is the area under the ROC curve (AUC) of 74.46%. Furthermore, comparative experiment has shown that our approach performs comparable to other existing methods with an accuracy of 94%, 90% and 96% for breast cancer, colonic cancer, and lung cancer respectively. In conclusion, these results support that our research has broadened new biological insights on identifying disease-related miRNAs.
authors.affiliation: Department of Computer Science, Yonsei University, Seoul, South Korea.
authors.forename: Jihwan
authors.initials: J
authors.lastname: Ha
authors.affiliation: Department of Computer Science, Yonsei University, Seoul, South Korea.
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Computer Engineering, Gachon University, Gyeonggi-do, South Korea.
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Yoon
authors.affiliation: Department of Computer Science, Yonsei University, Seoul, South Korea.
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Park
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000235:genetics*; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000235:genetics*; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers; D035683:MicroRNAs
keywords: disease; environmental factor; miRNA; network; propagation algorithm