title: Demixing of water and ethanol causes conformational redistribution and gelation of the cationic GAG tripeptide.
abstract: The cationic tripeptide GAG undergoes three conformational changes in binary mixtures of water and ethanol. At 17 mol% of ethanol conformational sampling is shifted from pPII towards β-strands. A more pronounced shift in the same direction occurs at 40 mol%. At ca. 55 mol% of ethanol and above a peptide concentration of ca. 0.2 M the ternary peptide-water-ethanol mixture forms a hydrogel which is comprised of unusually large crystalline like non-β sheet fibrils forming a sample spanning matrix.
authors.affiliation: Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, PA, USA. rschweitzer-stenner@drexel.edu.
authors.forename: Bridget
authors.initials: B
authors.lastname: Milorey
authors.affiliation: Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, PA, USA. rschweitzer-stenner@drexel.edu.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Farrell
authors.affiliation: Department of Chemistry, University of Pennsylvania, 231, South 34th-Street, Philadelphia, PA 19104, USA.
authors.forename: Siobhan E
authors.initials: SE
authors.lastname: Toal
authors.affiliation: Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, PA, USA. rschweitzer-stenner@drexel.edu.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schweitzer-Stenner
mesh_terms: D000431:Ethanol / Q000737:chemistry*; D005782:Gels; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry*
chemical_list: D005782:Gels; D010455:Peptides; D014867:Water; D000431:Ethanol