title: History before diagnosis in childhood craniopharyngioma: associations with initial presentation and long-term prognosis.
abstract: OBJECTIVE
  Childhood craniopharyngiomas (CP) are often diagnosed after a long duration of history (DOH). Tumor size, hypothalamic involvement (HI), and obesity are associated with reduced overall survival (OS) and functional capacity (FC). The effect of DOH and specific symptoms in history on presentation at initial diagnosis and long-term prognosis are unknown.
  
  
  METHODS
  Retrospective analysis of patients' records and prospective longitudinal follow-up.
  
  
  METHODS
  Histories of 411 CP patients recruited in HIT Endo, KRANIOPHARYNGEOM 2000 were retrospectively evaluated for DOH, symptoms, and characteristics. The effect of specific manifestations and DOH on clinical presentation and tumor characteristics at time of initial CP diagnosis and long-term outcome were analyzed. Main outcome measures were 10-year OS and progression-free survival (PFS), FC, and BMI during longitudinal follow-up.
  
  
  RESULTS
  Median DOH was 6 months (range: 0.1-108 months) and correlated with age at diagnosis. Tumor size, HI, degree of resection, and BMI at diagnosis were not related to DOH. In multivariate analysis adjusted for age at diagnosis, only hydrocephalus was found to have a relevant influence on DOH. Visual and neurological deficits were associated with larger initial tumor size and impaired 10-year OS. Weight gain and growth failure were observed with longest DOH. PFS and FC were not related to any specific symptom. Endocrine deficits at diagnosis were associated with long DOH.
  
  
  CONCLUSIONS
  CP is frequently diagnosed after long DOH, especially in older children. However, DOH was not associated with tumor size, HI, survival, or FC. Visual and neurological deficits necessitate rapid diagnostic workup.
authors.affiliation: Department of PediatricsKlinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133 Oldenburg, GermanyUniversity of GroningenGroningen, The NetherlandsInstitute of Biostatistics and Clinical ResearchUniversity of Münster, Münster, Germany.
authors.forename: Anika
authors.initials: A
authors.lastname: Hoffmann
authors.affiliation: Department of PediatricsKlinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133 Oldenburg, GermanyUniversity of GroningenGroningen, The NetherlandsInstitute of Biostatistics and Clinical ResearchUniversity of Münster, Münster, Germany.
authors.forename: Svenja
authors.initials: S
authors.lastname: Boekhoff
authors.affiliation: Department of PediatricsKlinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133 Oldenburg, GermanyUniversity of GroningenGroningen, The NetherlandsInstitute of Biostatistics and Clinical ResearchUniversity of Münster, Münster, Germany.
authors.forename: Ursel
authors.initials: U
authors.lastname: Gebhardt
authors.affiliation: Department of PediatricsKlinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133 Oldenburg, GermanyUniversity of GroningenGroningen, The NetherlandsInstitute of Biostatistics and Clinical ResearchUniversity of Münster, Münster, Germany Department of PediatricsKlinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133 Oldenburg, GermanyUniversity of GroningenGroningen, The NetherlandsInstitute of Biostatistics and Clinical ResearchUniversity of Münster, Münster, Germany.
authors.forename: Anthe S
authors.initials: AS
authors.lastname: Sterkenburg
authors.affiliation: Department of PediatricsKlinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133 Oldenburg, GermanyUniversity of GroningenGroningen, The NetherlandsInstitute of Biostatistics and Clinical ResearchUniversity of Münster, Münster, Germany Department of PediatricsKlinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133 Oldenburg, GermanyUniversity of GroningenGroningen, The NetherlandsInstitute of Biostatistics and Clinical ResearchUniversity of Münster, Münster, Germany.
authors.forename: Anna M M
authors.initials: AM
authors.lastname: Daubenbüchel
authors.affiliation: Department of PediatricsKlinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133 Oldenburg, GermanyUniversity of GroningenGroningen, The NetherlandsInstitute of Biostatistics and Clinical ResearchUniversity of Münster, Münster, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Eveslage
authors.affiliation: Department of PediatricsKlinikum Oldenburg, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133 Oldenburg, GermanyUniversity of GroningenGroningen, The NetherlandsInstitute of Biostatistics and Clinical ResearchUniversity of Münster, Münster, Germany mueller.hermann@klinikum-oldenburg.de.
authors.forename: Hermann L
authors.initials: HL
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003397:Craniopharyngioma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D057210:Delayed Diagnosis; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000209:etiology; D006261:Headache / Q000209:etiology; D006801:Humans; D007031:Hypothalamus / Q000473:pathology*; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D009325:Nausea / Q000209:etiology; D009765:Obesity / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D059606:Polydipsia / Q000209:etiology; D011141:Polyuria / Q000209:etiology; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D047368:Tumor Burden; D014786:Vision Disorders / Q000209:etiology; D055815:Young Adult