title: Acoustic signal characteristics of laser induced cavitation in DDFP droplet: Spectrum and time-frequency analysis.
abstract: Cavitation has great application potential in microvessel damage and targeted drug delivery. Concerning cavitation, droplet vaporization has been widely investigated in vitro and in vivo with plasmonic nanoparticles. Droplets with a liquid dodecafluoropentane (DDFP) core enclosed in an albumin shell have a stable and simple structure with good characteristics of laser absorbing; thus, DDFP droplets could be an effective aim for laser-induced cavitation. The DDPF droplet was prepared and perfused in a mimic microvessel in the optical microscopic system with a passive acoustic detection module. Three patterns of laser-induced cavitation in the droplets were observed. The emitted acoustic signals showed specific spectrum components at specific time points. It was suggested that a nanosecond laser pulse could induce cavitation in DDPF droplets, and specific acoustic signals would be emitted. Analyzing its characteristics could aid in monitoring the laser-induced cavitation process in droplets, which is meaningful to theranostic application.
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P.R. China.
authors.forename: Dui
authors.initials: D
authors.lastname: Qin
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P.R. China.
authors.forename: Chenxiang
authors.initials: C
authors.lastname: Ma
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P.R. China.
authors.forename: Mingxi
authors.initials: M
authors.lastname: Wan
mesh_terms: D004307:Dose-Response Relationship, Radiation; D005466:Fluorocarbons / Q000737:chemistry* / Q000528:radiation effects*; D005740:Gases / Q000138:chemical synthesis* / Q000528:radiation effects*; D008027:Light; D011829:Radiation Dosage; D013016:Sound; D010420:Pentanes
chemical_list: D005466:Fluorocarbons; D005740:Gases; C008806:perfluoropentane; D010420:Pentanes
keywords: DDFP droplet; acoustic signal; laser induced cavitation; spectrum analysis; time-frequency analysis