title: Platelet mimicry: The emperor's new clothes?
abstract: Here we critically examine whether coating of nanoparticles with platelet membranes can truly disguise them against recognition by elements of the innate immune system. We further assess whether the "cloaking technology" can sufficiently equip nanoparticles with platelet-mimicking functionalities to include in vivo targeting of damaged blood vessels and binding to platelet-adhering opportunistic pathogens. We present views for improved, and pharmaceutically viable nanoparticle design strategies.
authors.affiliation: Centre for Pharmaceutical Nanotechnology and Nanotoxicology and Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark. Electronic address: moein.moghimi@gmail.com.
authors.forename: Seyed Moein
authors.initials: SM
authors.lastname: Moghimi
authors.affiliation: Manchester Pharmacy School, University of Manchester, Manchester, UK. Electronic address: christy.hunter@manchester.ac.uk.
authors.forename: Alan Christy
authors.initials: AC
authors.lastname: Hunter
authors.affiliation: Laboratory of Nanomedicine, Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel; Department of Materials Science and Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel. Electronic address: peer@tauex.tau.ac.il.
authors.forename: Dan
authors.initials: D
authors.lastname: Peer
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001792:Blood Platelets / Q000166:cytology*; D002462:Cell Membrane / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D010973:Platelet Adhesiveness
chemical_list: D000900:Anti-Bacterial Agents
keywords: Complement; Innate immunity; Macrophage; Nanoparticles; Platelets