title: Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma.
abstract: The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C alleles in controls were found to be within the parameters of Hardy-Weinberg equilibrium, but the genotype frequencies of +936C/T alleles were not. By conditional regression analysis, we detected a statistically significantly increased risk of osteosarcoma in patients with the AA genotype (OR = 1.97; 95%CI = 1.02-3.83) and the CA+AA genotype (OR = 1.57; 95%CI = 1.01-2.44) of -2578C/A when compared with CC genotype. Therefore, our study showed that the AA and CA+AA genotypes of the VEGF -2578C/A polymorphism might modify the risk of osteosarcoma in a Chinese population.
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Weifang Medical University, Shandong, China.
authors.forename: H F
authors.initials: HF
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Weifang Medical University, Shandong, China.
authors.forename: J P
authors.initials: JP
authors.lastname: Yan
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Weifang Medical University, Shandong, China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Zhuang
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Weifang Medical University, Shandong, China.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People; D001859:Bone Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012516:Osteosarcoma / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D012306:Risk; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A