title: Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.
abstract: More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital , Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States.
authors.forename: Sijumon
authors.initials: S
authors.lastname: Kunjachan
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital , Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States.|Institut Lumière Matière, Université Claude Bernard Lyon1-CNRS, Université de Lyon , 69007 Lyon, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Detappe
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital , Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States.|Nanomedicine Science and Technology Center and Department of Physics, Northeastern University , Boston, Massachusetts 02115, United States.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Kumar
authors.affiliation: LA-ICP-MS and ICP-ES Laboratories, Boston University , Boston, Massachusetts 02215, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ireland
authors.affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute , Boston, Massachusetts 02215, United States.
authors.forename: Lisa
authors.initials: L
authors.lastname: Cameron
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital , Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States.
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Biancur
authors.affiliation: Institut Lumière Matière, Université Claude Bernard Lyon1-CNRS, Université de Lyon , 69007 Lyon, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Motto-Ros
authors.affiliation: Institut Lumière Matière, Université Claude Bernard Lyon1-CNRS, Université de Lyon , 69007 Lyon, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital , Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States.|Nanomedicine Science and Technology Center and Department of Physics, Northeastern University , Boston, Massachusetts 02115, United States.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Sridhar
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital , Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States.
authors.forename: G Mike
authors.initials: GM
authors.lastname: Makrigiorgos
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital , Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States.
authors.forename: Ross I
authors.initials: RI
authors.lastname: Berbeco
mesh_terms: D045744:Cell Line, Tumor; D004727:Endothelium / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D006046:Gold / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D011836:Radiation Tolerance / Q000187:drug effects; D061089:Radiotherapy, Image-Guided
chemical_list: D006046:Gold
keywords: Gold nanoparticles; endothelial radiation damage; image-guided radiation therapy; tumor vascular disruption