title: Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours.
abstract: OBJECTIVE
  To explore the correlations of conventional MRI (cMRI) and diffusion tensor imaging (DTI) values with the 1p/19 codeletion and IDH mutations in oligodendroglial tumours (OTs).
  
  
  METHODS
  Eighty-four patients with OTs who underwent cMRI and DTI were retrospectively reviewed. The maximal fractional anisotropy and minimal apparent diffusion coefficient (ADC) were measured and compared using the Mann-Whitney U test. Receiver operating characteristic curves, logistic regression analysis and four-table statistics analysis were performed to predict genotypings.
  
  
  RESULTS
  OTs with 1p/19q codeletion or IDH mutations were prone to locate in frontal (P = 0.106 and 0.005, respectively) and insular lobes and were associated with absent or blurry contrast enhancement (P = 0.040 and 0.013, respectively). DTI values showed significant differences between OTs with and without IDH mutations (P < 0.05) but not in OTs with and without 1p/19q loss. The Ki-67 index significantly correlated with IDH mutations (P = 0.002) but not with 1p/19q codeletion. A combination of DTI and cMRI for the identification of IDH mutations resulted in sensitivity, specificity, positive and negative predictive values of 92.2 %, 75.8 %, 93.8 % and 71.1 %, respectively.
  
  
  CONCLUSIONS
  Combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in OTs.
  
  
  CONCLUSIONS
  • OTs with 1p/19q codeletion were associated with absent or blurry contrast enhancement • OTs with IDH mutations were also associated with absent or blurry contrast enhancement • OTs with IDH mutations were prone to locate in frontal and insular lobes • DTI values can provide a non-invasive method for assessing the IDH status of OTs • A combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations.
authors.affiliation: Department of Radiology, Huashan Hospital of Fudan University, No. 12 the Middle Wu Lu Mu Qi Road, Shanghai, 200040, China.|Department of Neuropathology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Wenli
authors.initials: W
authors.lastname: Tan
authors.affiliation: Department of Radiology, Huashan Hospital of Fudan University, No. 12 the Middle Wu Lu Mu Qi Road, Shanghai, 200040, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wen
authors.affiliation: Department of Radiology, Huashan Hospital of Fudan University, No. 12 the Middle Wu Lu Mu Qi Road, Shanghai, 200040, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Neuropathology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Huashan Hospital of Fudan University, No. 12 the Middle Wu Lu Mu Qi Road, Shanghai, 200040, China. zhj81828@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Huashan Hospital of Fudan University, No. 12 the Middle Wu Lu Mu Qi Road, Shanghai, 200040, China. daoyinggeng@163.com.
authors.forename: Daoying
authors.initials: D
authors.lastname: Geng
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D005838:Genotype; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009154:Mutation / Q000235:genetics*; D009837:Oligodendroglioma / Q000235:genetics* / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D007521:Isocitrate Dehydrogenase
keywords: 1p/19q codeletion; Conventional MRI; Diffusion tensor imaging; Isocitrate dehydrogenase gene; Oligodendroglial tumours