title: MicroRNA-339, an epigenetic modulating target is involved in human gastric carcinogenesis through targeting NOVA1.
abstract: The role of miR-339 in human gastric cancer (GC) remains unclear. Here, we found that miR-339 is remarkably decreased in primary GC tissues. Overexpression of miR-339 in GC cells significantly suppressed proliferation, migration, invasion, and tumorigenicity. Furthermore, NOVA1 was confirmed as a target of miR-339. Restoration of NOVA1 in miR-339-overexpressing GC cells partially impaired the inhibitory effects of miR-339. More importantly, epigenetic modification may be involved in the modulation of miR-339 expression. These findings uncover a novel role for miR-339 in gastric carcinogenesis, and restoration of miR-339 could be considered as a potential therapeutic strategy for GC treatment.
authors.affiliation: Department of oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210009, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.affiliation: Department of oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210009, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210009, China.
authors.forename: Shaorong
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210009, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210009, China.
authors.forename: Yuejiao
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Department of oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210009, China. Electronic address: lujw_med@163.com.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province 210009, China. Electronic address: fengjf0518@126.com.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Feng
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D019175:DNA Methylation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D000090682:Neuro-Oncological Ventral Antigen; D016601:RNA-Binding Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D014183:Transplantation, Heterologous
chemical_list: D020413:3' Untranslated Regions; C543820:MIRN339 microRNA, human; D035683:MicroRNAs; C000594513:NOVA1 protein, human; D000090682:Neuro-Oncological Ventral Antigen; D016601:RNA-Binding Proteins
keywords: Gastric cancer; Methylation; NOVA1; Proliferation; miR-339