title: Three new 1α-alkyldaphnane-type diterpenoids from the flower buds of Wikstroemia chamaedaphne.
abstract: Three new 1α-alkyldaphnane type diterpenoids, wikstroelides R-T (1-3), together with three known analogs, genkwadane C (4), pimelea factors S6 (5) and S7 (6), two known 1α-alkyldaphnane ketal-lactone type diterpenoids, pimelotides A (7) and C (8), and a known daphnane type diterpenoid, simplexin (9), were isolated from the flower buds of Wikstroemia chamaedaphne. Their structures were elucidated by a combination of spectroscopic analyses including HRESIMS and NMR. Compounds 1-9 were evaluated for their cytotoxic activities in vitro, and most of them exhibited moderate cytotoxic activities with IC50 values ranging from 8.7-22.0 μM.
authors.affiliation: Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Jieru
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Physical Medicine and Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tian
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Guangmin
authors.initials: G
authors.lastname: Yao
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Hucheng
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Zengwei
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Jinwen
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: hust.yuanzhang75@hotmail.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: zhangyh@mails.tjmu.edu.cn.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D035264:Flowers / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D032365:Wikstroemia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes
keywords: Cytotoxicity; Diterpenoid; Wikstroemia chamaedaphne