title: Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance.
abstract: Th0 cells differentiate into Th1 or Th2 depending on multiple transcription factors acting on specific time points to regulate gene expression. Th17 cells, a subset of IL-17-producing T cells distinct from Th1 or Th2 cells, have been described as key players in inflammation and autoimmune diseases as well as cancer development. In the present study, 53 patients with hypopharyngeal cancer were included. The expression levels of Th1-, Th2- and Th17-associated cytokines in hypopharyngeal cancer tissues and pericarcinoma tissues were detected. The relationship between Th1, Th2, or Th17 infiltration and metastasis was studied. Our results showed that the mRNA and protein expressions of Th1 cytokines were lower, while the expressions of Th2 and Th17 cytokines were higher in tumor tissues, and the intensity of expression was strengthened with clinical stage increasing. Cancer tissues had higher level expressions of Th2 and Th17 cytokines than that of pericarcinoma tissues. From the above data, we speculated that high expressions of Th2- and Th17-associated cytokines in hypopharyngeal carcinoma may contribute to cancer development and metastasis.
authors.affiliation: Department of Otolaryngology, The Second Hospital of Shandong University, 247 Beiyuan Avenue, Jinan, 250033, Shandong, People's Republic of China. chxmsd@163.com.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan, 250062, Shandong, People's Republic of China.
authors.forename: Junfu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Heze Municipal Hospital, Heze, 274000, Shandong, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan, 250062, Shandong, People's Republic of China.
authors.forename: Qinghong
authors.initials: Q
authors.lastname: Su
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan, 250062, Shandong, People's Republic of China.
authors.forename: Junwen
authors.initials: J
authors.lastname: Luan
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan, 250062, Shandong, People's Republic of China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Huang
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan, 250062, Shandong, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan, 250062, Shandong, People's Republic of China.
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877 Jingshi Road, Jinan, 250062, Shandong, People's Republic of China. xuxiaoqunsd@163.com.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D015153:Blotting, Western; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D007111:Immunity, Cellular / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012334:RNA, Neoplasm / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018417:Th1 Cells / Q000378:metabolism*; D058504:Th17 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*
chemical_list: D016207:Cytokines; D012334:RNA, Neoplasm
keywords: Cytokine; Hypopharyngeal carcinoma; Th1; Th17; Th2