title: In vivo contaminant partitioning to silicone implants: Implications for use in biomonitoring and body burden.
abstract: Silicone polymers are used for a wide array of applications from passive samplers in environmental studies, to implants used in human augmentation and reconstruction. If silicone sequesters toxicants throughout implantation, it may represent a history of exposure and potentially reduce the body burden of toxicants influencing the risk of adverse health outcomes such as breast cancer. Objectives of this research included identifying a wide variety of toxicants in human silicone implants, and measuring the in vivo absorption of contaminants into silicone and surrounding tissue in an animal model. In the first study, eight human breast implants were analyzed for over 1400 organic contaminants including consumer products, chemicals in commerce, and pesticides. A total of 14 compounds including pesticides such as trans-nonachlor (1.2-5.9ng/g) and p,p'-DDE (1.2-34ng/g) were identified in human implants, 13 of which have not been previously reported in silicone prostheses. In the second project, female ICR mice were implanted with silicone and dosed with p,p'-DDE and PCB118 by intraperitoneal injection. After nine days, silicone and adipose samples were collected, and all implants in dosed mice had p,p'-DDE and PCB118 present. Distribution ratios from silicone and surrounding tissue in mice compare well with similar studies, and were used to predict adipose concentrations in human tissue. Similarities between predicted and measured chemical concentrations in mice and humans suggest that silicone may be a reliable surrogate measure of persistent toxicants. More research is needed to identify the potential of silicone implants to refine the predictive quality of chemicals found in silicone implants.
authors.affiliation: Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: O'Connell
authors.affiliation: Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Nancy I
authors.initials: NI
authors.lastname: Kerkvliet
authors.affiliation: College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Carozza
authors.affiliation: Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Rohlman
authors.affiliation: Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Jamie
authors.initials: J
authors.lastname: Pennington
authors.affiliation: Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA. Electronic address: kim.anderson@oregonstate.edu.
authors.forename: Kim A
authors.initials: KA
authors.lastname: Anderson
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000818:Animals; D001822:Body Burden; D018427:Breast Implants; D003633:Dichlorodiphenyl Dichloroethylene / Q000032:analysis / Q000493:pharmacokinetics; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis / Q000493:pharmacokinetics; D051379:Mice; D008813:Mice, Inbred ICR; D010575:Pesticides / Q000032:analysis* / Q000493:pharmacokinetics; D012828:Silicones / Q000032:analysis*
chemical_list: D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D012828:Silicones; C001870:nonachlor; D003633:Dichlorodiphenyl Dichloroethylene
keywords: Adipose; Biomonitoring; Implants; In vivo; Pesticides; Silicone