title: Dropwort (Filipendula hexapetala Gilib.): potential role as antioxidant and antimicrobial agent.
abstract: The aim of this study was to investigate the antioxidant activity of the methanolic extracts of Filipendula hexapetala Gilib. aerial parts (FHA) and roots (FHR) and their potential in different model systems, as well as antimicrobial activity. According to this, a number of assays were employed to evaluate the antioxidant and antimicrobial potential of F. hexapetala extracts. In addition, the antioxidant activity assays in different model systems were carried out, as well as pH, thermal and gastrointestinal stability studies. The phenolic compounds contents in FHA and FHR were also determined. The results showed that F. hexapetala extracts had considerable antioxidant activity in vitro and a great stability in different conditions. The extracts exhibited antimicrobial activity against most of the tested bacterial and fungal species. Also, the extracts contain high level of phenolic compounds, especially aerial parts extract.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Katanic
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Mihailovic
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
authors.forename: Nevena
authors.initials: N
authors.lastname: Stankovic
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Boroja
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Mladenovic
authors.affiliation: Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
authors.forename: Slavica
authors.initials: S
authors.lastname: Solujic
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
authors.forename: Milan S
authors.initials: MS
authors.lastname: Stankovic
authors.affiliation: Faculty of Chemistry, University of Belgrade, Studentski trg 16, P.O. Box 51, 11158 Belgrade, Serbia.
authors.forename: Miroslav M
authors.initials: MM
authors.lastname: Vrvic
keywords: Filipendula hexapetala Gilib.; antimicrobial activity; antioxidant activity; in vitro digestion; phenolic compounds; stability