title: No Evidence of Human Leukocyte Antigen Gene Association With Rheumatic Fever Among Children in Samoa.
abstract: Human leukocyte antigens (HLAs) have been implicated in rheumatic fever pathogenesis. This pilot whole genome association study compares genotypes of Samoan children with rheumatic fever to unaffected siblings and unrelated healthy controls. No risk-related genotypes were associated with HLA genes. Thirteen Regions of Interest were identified as candidates for further study.
authors.affiliation: Department of Pediatrics.
authors.forename: Guliz
authors.initials: G
authors.lastname: Erdem
authors.affiliation: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Seifried
mesh_terms: D002648:Child; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D012213:Rheumatic Fever / Q000235:genetics*; D018947:Samoa; D035781:Siblings
chemical_list: D006680:HLA Antigens
keywords: Polynesian; genome-wide association study; rheumatic fever.