title: Adeno-associated virus finds its disease.
abstract: Adeno-associated virus (AAV) vectors have been widely adopted for use in gene therapy. A new study raises concerns regarding this approach, reporting that chromosomal insertions of AAV serotype 2 seem to activate proto-oncogenes in human hepatocellular carcinoma.
authors.affiliation: Departments of Medicine and Biochemistry, University of Washington, Seattle, Washington, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Russell
authors.affiliation: Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon, USA.
authors.forename: Markus
authors.initials: M
authors.lastname: Grompe
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D000229:Dependovirus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D016254:Mutagenesis, Insertional