title: Preparation of polysaccharide loaded collagen membrane with anti-oxidative activity.
abstract: The scavenging activity of polysaccharides from Lycium barbarum, Lentinus edodes and Ganoderma Lucidum Karst to DPPH free radicals was investigated. It was found that among the three polysaccharides, Lycium barbarum polysaccharides (LBP) exhibits the best scavenging activity. Polysaccharide loaded collagen membranes were prepared by mixing LBP with collagen, starch, glycerol, sodium carboxymethyl cellulose and glutaraldehyde. In vitro drug release from membranes was evaluated. With increasing the immersion time, the release rate first increases and then slows down. Meanwhile, the scavenging activity to DPPH radicals exhibits similar variation, in agreement with a good release effect of the membrane. The optimal formulation of collagen membrane and preparation parameters were obtained considering the overall properties and the scavenging activity to radicals.
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
authors.forename: Zibin
authors.initials: Z
authors.lastname: Shu
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Ding
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: He
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Dai
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Leng
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
authors.forename: Yanshun
authors.initials: Y
authors.lastname: Ma
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage / Q000138:chemical synthesis; D003094:Collagen / Q000008:administration & dosage / Q000737:chemistry*; D004058:Diffusion; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000737:chemistry; D008422:Materials Testing; D008567:Membranes, Artificial; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D020099:Coated Materials, Biocompatible; D016166:Free Radical Scavengers; D008567:Membranes, Artificial; D053769:Nanocapsules; D010851:Picrates; D011134:Polysaccharides; D003094:Collagen; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Collagen; anti-oxidative; drug release; lycium barbarum polysaccharides; membrane