title: [Arterial pathology in migraine: endothelial dysfunction and structural changes in the brain and systemic vasculature].
abstract: BACKGROUND
  The pathophysiology underlying the association between migraine and other non-atherosclerotic vascular diseases is largely unknown. Endothelial dysfunction has been proposed as a common link. Besides, endothelial dysfunction is considered as a predictor of structural changes in the arterial walls.
  
  
  OBJECTIVE
  To review the current knowledge about the functional (endothelial dysfunction) and structural (arterial stiffness and atherosclerotic diseases) arterial properties associated with migraine.
  
  
  METHODS
  Studies of biological markers of endothelial dysfunction in peripheral blood, systemic and cerebral vasoreactivity, arterial stiffness indexes and direct visualization of macroscopic changes in the arterial wall have shown differences between patients with and without migraine, as well as between the different migraine subtypes.
  
  
  CONCLUSIONS
  Endothelial dysfunction, as a predictor of structural changes in arteries, has been proposed as an early marker for vascular pathology associated with migraine. In migraine patients there is an increase of biomarkers of endothelial dysfunction, but the correlation with vasoreactivity studies does not allow definite conclusions. Available data do not allow to conclude that migraine is associated with macroscopic alterations outside the cerebral arterial bed.
authors.affiliation: Hospital Universitario Central de Asturias, 33006 Oviedo, Espana.
authors.forename: Davinia
authors.initials: D
authors.lastname: Larrosa-Campo
authors.forename: César
authors.initials: C
authors.lastname: Ramón-Carbajo
authors.forename: Rocío
authors.initials: R
authors.lastname: Álvarez-Escudero
authors.forename: Eva
authors.initials: E
authors.lastname: Cernuda-Morollón
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Cabo
authors.forename: Julio
authors.initials: J
authors.lastname: Pascual
mesh_terms: D055109:Ankle Brachial Index; D001158:Arteries / Q000473:pathology* / Q000503:physiopathology; D001916:Brachial Artery / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D055252:Cell-Derived Microparticles; D002536:Cerebral Arteries / Q000503:physiopathology; D042783:Endothelial Cells / Q000473:pathology; D019332:Endothelin-1 / Q000378:metabolism; D004730:Endothelium, Vascular / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008365:Manometry; D008881:Migraine Disorders / Q000473:pathology* / Q000503:physiopathology; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000503:physiopathology; D063177:Pulse Wave Analysis; D012038:Regeneration; D019851:Thrombophilia / Q000209:etiology / Q000503:physiopathology; D059289:Vascular Stiffness; D014664:Vasodilation
chemical_list: D019332:Endothelin-1; D009569:Nitric Oxide