title: [Cognitive rehabilitation in early stage Alzheimer's disease].
abstract: BACKGROUND
  Dementia impairs the coping with routine daily tasks and social relationships due to an increasing degeneration of cognitive abilities. An appropriate treatment must adequately consider the effects of declined cognitive abilities on patients and their environment. Therefore, in recent times, integrative procedures for cognitive rehabilitation (CR) have become increasingly important for the therapy of patients with mild cognitive impairment (MCI) and mild dementia (MD). CR approaches provide compensatory possibilities for clearly defined routine challenges and the individual needs of those affected.
  
  
  METHODS
  This overview article in the form of a selective review elaborates factors for the effectiveness of CR on the basis of the currently available literature: 1) individuality - consideration of personal needs and targets, 2) compensation - mediation of skills and strategies to compensate for cognitive impairments, 3) interaction - inclusion of relatives and environmental conditions and 4) integration - integration of various therapeutic disciplines and methods.
  
  
  CONCLUSIONS
  On the basis of this assessment with regards to the content, a critical analysis of the methods of short and long-term therapeutic effects on MCD and MD was carried out. Although the resulting factors were of high long-term relevance for the improvement of depression and quality of life, effects on cognition were more pronounced for MCI than for MD, which emphasizes the importance of beginning therapy as early as possible. The results show that future studies on effectiveness must employ endpoints relevant for routine daily life, and that the possibility of an implementation of therapeutic concepts in a healthcare system should be considered as an essential criterion.
authors.affiliation: Klinik und Poliklinik für Psychosomatik und Psychotherapeutische Medizin, Universitätsmedizin Rostock, Gehlsheimer Str. 20, 18147, Rostock, Deutschland. elisabeth.kasper@med.uni-rostock.de.
authors.forename: E
authors.initials: E
authors.lastname: Kasper
authors.affiliation: Tagesklinik für Kognitive Neurologie, Universität Leipzig, Leipzig, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Thöne-Otto
authors.affiliation: Institut für Schlaganfallforschung, Klinikum der Universität München, München, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Bürger
authors.affiliation: Klinik für Psychiatrie und Psychotherapie, KMG Klinikum Güstrow, Arbeitsgruppe Gerontopsychiatrie der Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Deutschland.
authors.forename: S G
authors.initials: SG
authors.lastname: Schröder
authors.affiliation: Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Standort Rostock/Greifswald, Rostock/Greifswald, Deutschland.
authors.forename: W
authors.initials: W
authors.lastname: Hoffmann
authors.affiliation: Klinik und Poliklinik für Psychosomatik und Psychotherapeutische Medizin, Universitätsmedizin Rostock, Gehlsheimer Str. 20, 18147, Rostock, Deutschland.
authors.forename: W
authors.initials: W
authors.lastname: Schneider
authors.affiliation: Klinik und Poliklinik für Psychosomatik und Psychotherapeutische Medizin, Universitätsmedizin Rostock, Gehlsheimer Str. 20, 18147, Rostock, Deutschland.|Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Standort Rostock/Greifswald, Rostock/Greifswald, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Teipel
mesh_terms: D000544:Alzheimer Disease / Q000523:psychology* / Q000534:rehabilitation*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D060825:Cognitive Dysfunction / Q000523:psychology* / Q000534:rehabilitation*; D019317:Evidence-Based Medicine; D005858:Germany; D006801:Humans; D000066530:Neurological Rehabilitation / Q000379:methods*; D016896:Treatment Outcome
keywords: Alzheimer’s disease; Cognitive rehabilitation; Cognitive training; Dementia; Mild cognitive disorder