title: BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence.
abstract: OBJECTIVE
  Association of the brain-derived neurotrophic factor (BDNF) genetic polymorphism rs6265 (Val66Met) with methamphetamine (METH) dependence and METH-induced psychosis was investigated in the Thai population.
  
  
  METHODS
  The rs6265 genotype was determined in 100 male METH-dependent subjects and 102 controls using a real-time PCR high-resolution melt (RT-PCR-HRM) assay.
  
  
  RESULTS
  The rs6265 genotype demonstrated significant differences in distribution between METH-dependent subjects and controls in which the frequency of GG genotype versus A-allele carriers was associated with METH dependence. Moreover, a significant effect of genotype on the occurrence of psychosis was found, with a lower frequency of GG genotype associated with METH-induced psychosis.
  
  
  CONCLUSIONS
  The present findings indicate that rs6265 is associated with METH dependence in the Thai population, with the GG genotype greater in METH-dependent subjects but reducing the emergence of METH-dependent psychosis.
authors.affiliation: Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.|Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Sri-Arun
authors.initials: SA
authors.lastname: Iamjan
authors.affiliation: Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.|Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Samur
authors.initials: S
authors.lastname: Thanoi
authors.affiliation: Synphaet Hospital, Bangkok, Thailand.
authors.forename: Paritat
authors.initials: P
authors.lastname: Watiktinkorn
authors.affiliation: Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.|Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Sutisa
authors.initials: S
authors.lastname: Nudmamud-Thanoi
authors.affiliation: Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.|Biomedical Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK.
authors.forename: Gavin P
authors.initials: GP
authors.lastname: Reynolds
mesh_terms: D019969:Amphetamine-Related Disorders / Q000453:epidemiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D000697:Central Nervous System Stimulants; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008694:Methamphetamine; D011110:Polymorphism, Genetic / Q000235:genetics*; D011605:Psychoses, Substance-Induced / Q000453:epidemiology / Q000235:genetics; D013785:Thailand / Q000453:epidemiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D000697:Central Nervous System Stimulants; D008694:Methamphetamine; C579455:BDNF protein, human
keywords: BDNF; methamphetamine dependence; polymorphism; psychosis; rs6265