title: The effects of severe iron-deficiency anaemia on maternal and neonatal outcomes: A case-control study in an inner-city London hospital.
abstract: This case-control study investigates the effects of severe iron-deficiency anaemia in pregnancy on maternal and neonatal outcomes in a relatively deprived inner-city population in a North London hospital. The study group comprised of 106 women with haemoglobin (Hb) < 8 g/dl at any point during pregnancy, while controls were 106 women with Hb > 11 g/dl throughout pregnancy. The study group lost an average of 80 ml more blood at delivery (p = 0.032) and had higher rates of postpartum haemorrhage than the control group (27 vs 12 patients, p = 0.012). However, anaemia did not appear to influence other maternal or neonatal outcomes; these may have been confounded by antenatal intervention with oral haematinics or blood transfusion.
authors.affiliation: a Departments of Obstetrics and Gynaecology , North Middlesex University Hospital , London , UK.
authors.forename: J
authors.initials: J
authors.lastname: Luis
authors.affiliation: b Departments of Medicine , University College London , London , UK.
authors.forename: M G
authors.initials: MG
authors.lastname: Fadel
authors.affiliation: a Departments of Obstetrics and Gynaecology , North Middlesex University Hospital , London , UK.
authors.forename: G Y
authors.initials: GY
authors.lastname: Lau
authors.affiliation: a Departments of Obstetrics and Gynaecology , North Middlesex University Hospital , London , UK.
authors.forename: S
authors.initials: S
authors.lastname: Houssein
authors.affiliation: a Departments of Obstetrics and Gynaecology , North Middlesex University Hospital , London , UK.
authors.forename: N
authors.initials: N
authors.lastname: Ravikumar
authors.affiliation: a Departments of Obstetrics and Gynaecology , North Middlesex University Hospital , London , UK.
authors.forename: W
authors.initials: W
authors.lastname: Yoong
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000150:complications*; D016022:Case-Control Studies; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006786:Hospitals, Urban; D006801:Humans; D007501:Iron / Q000097:blood; D008131:London; D006473:Postpartum Hemorrhage / Q000209:etiology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood; D011256:Pregnancy Outcome; D012189:Retrospective Studies
chemical_list: D006454:Hemoglobins; D007501:Iron
keywords: Anaemia; neonatal outcomes; postpartum haemorrhage; pregnancy