title: Obstetrical Mode of Delivery and Childhood Behavior and Psychological Development in a British Cohort.
abstract: The association between mode of delivery [specifically birth by Cesarean section (CS)] and induction of labor (IOL) psychological development at age 7 was assessed [including autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder (ADHD) and behavioral difficulties]. The Millennium cohort study, a nationally representative UK cohort of children (including 13,141 children), was used. There was no association between planned CS and ASD [aOR 0.58; (95 % CI 0.19-1.79)] or ADHD [aOR 0.54; (95 % CI 0.18-1.64)] analyses. Induced vaginal delivery was significantly associated with behavioral difficulties in unadjusted [OR 1.26; (95 % CI 1.03-1.54)], but not adjusted analysis [OR 1.15; (95 % CI 0.82-1.60)]. There was no association between mode of delivery and ASD or ADHD in this cohort. Further research is needed to understand the relationship between mode of delivery and IOL and psychological development.
authors.affiliation: The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, 5th Floor Cork University Maternity Hospital, Wilton, Cork, Ireland. ecurran@ucc.ie.
authors.forename: Eileen A
authors.initials: EA
authors.lastname: Curran
authors.affiliation: APC Microbiome Institute, Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
authors.forename: John F
authors.initials: JF
authors.lastname: Cryan
authors.affiliation: The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, 5th Floor Cork University Maternity Hospital, Wilton, Cork, Ireland.
authors.forename: Louise C
authors.initials: LC
authors.lastname: Kenny
authors.affiliation: APC Microbiome Institute, Department of Psychiatry, University College Cork, Cork, Ireland.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Dinan
authors.affiliation: Department of Epidemiology and Public Health, University College Cork, Cork, Ireland.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Kearney
authors.affiliation: The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, 5th Floor Cork University Maternity Hospital, Wilton, Cork, Ireland.|Department of Epidemiology and Public Health, University College Cork, Cork, Ireland.
authors.forename: Ali S
authors.initials: AS
authors.lastname: Khashan
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology*; D000067877:Autism Spectrum Disorder / Q000453:epidemiology*; D002585:Cesarean Section / Q000009:adverse effects*; D002648:Child; D002657:Child Development; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000009:adverse effects*; D008297:Male; D011247:Pregnancy; D000066553:Problem Behavior; D006113:United Kingdom / Q000453:epidemiology
keywords: ADHD; Autism spectrum disorder; Induction of labor; Mode of delivery