title: Effect of full-mouth disinfection on insulin sensitivity in type 2 diabetes patients with and without chronic periodontitis.
abstract: OBJECTIVE
  To explore the effect of full-mouth disinfection (FMD) on glycemic control and insulin resistance in type 2 diabetes mellitus (DM).
  
  
  METHODS
  Sixty dentate patients who were never-smokers with type 2 diabetes mellitus were recruited for the study. Based on clinical examination they were divided into two groups: one with chronic periodontitis and the other without chronic periodontitis. Periodontal parameters Plaque Index (PI), Gingival Index (GI), and probing pocket depth (PPD) were evaluated. Blood samples were assessed for the levels of fasting glucose (FG), insulin, and C-reactive protein (CRP), and insulin glucose ratio was calculated using a mathematical equation (HOMA-IR). All parameters were assessed at baseline, and at 3 months and 6 months after FMD.
  
  
  RESULTS
  The results showed a significant reduction in PI, GI, PPD, FG, and HOMA-IR from baseline to 6 months. The CRP levels were constant throughout the study period.
  
  
  CONCLUSIONS
  Within the limitations of the present study it can be concluded that FMD contributes to significant reduction in insulin resistance, thereby improving the glycemic control in type 2 diabetes mellitus patients.
authors.forename: Sridharan
authors.initials: S
authors.lastname: Srirangarajan
authors.forename: Rekha
authors.initials: R
authors.lastname: Setty
authors.forename: Aparna
authors.initials: A
authors.lastname: Satyanarayan
authors.forename: Shreya
authors.initials: S
authors.lastname: Shetty
mesh_terms: D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000378:metabolism; D002710:Chlorhexidine / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000150:complications* / Q000188:drug therapy*; D003774:Dental Plaque Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004203:Disinfection / Q000379:methods*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D001786:Blood Glucose; D007328:Insulin; D002097:C-Reactive Protein; D002710:Chlorhexidine