title: [Influence on Strychni Semen's Analgesic Effect and Toxicity of Milk-Impregnated- Processing-Technology of Traditional Uighur Medicine].
abstract: OBJECTIVE
  To investigate the effects of different processing methods on analgesic effect and toxicity of Strychni Semen, and to provide the scientific basis of milk-impregnated-processing-technology of traditional Uighur medicine for toxic medicines.
  
  
  METHODS
  Three different methods, frying with sand of traditional Chinese medicine (1), cooled milk-impregnated-processing-technology of traditional Uighur medicine (2), and heated milk-impregnated-processing-technology of traditional Uighur medicine (3) were used to process raw Strychni Semen and the processed products were compared with those in the raw drug (4). Karber method was used to caculate the LD50.
  
  
  RESULTS
  The LD50 of (4), (1), (2) and (3)were 273.0, 289.3, 289.3 and 339.2 mg/kg,successively. Low dose group of heated milk-impregnated-processing-technology, low and high dose groups of cooled milk-impregnated-processing-technology had significant inhibition on the acetic acid-induced writhing reaction in mice (P < 0.05).
  
  
  CONCLUSIONS
  Strychni Semen processed by cooled and heated milk can enhance the analgesic effect in mice while improving the LD50 of mouse, which illustrates milk-impregnated-processing- technology's pharmacological mechanism on efficacy enhancing and toxicity reducing of Strychni Semen.
authors.forename: D
authors.initials: D
authors.lastname: Tursun
authors.forename: Yu-zhu
authors.initials: YZ
authors.lastname: Shi
authors.forename: Qiao-li
authors.initials: QL
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Wen-cai
authors.initials: WC
authors.lastname: Xue
authors.forename: A
authors.initials: A
authors.lastname: Abas
authors.forename: Wei-jun
authors.initials: WJ
authors.lastname: Yang
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006358:Hot Temperature; D008516:Medicine, Chinese Traditional; D051379:Mice; D008892:Milk; D012639:Seeds / Q000737:chemistry; D031461:Strychnos nux-vomica / Q000737:chemistry*
chemical_list: D000700:Analgesics; D004365:Drugs, Chinese Herbal