title: Hemodynamics investigation for a giant aneurysm treated by a flow diverter implantation.
abstract: Flow diverter is a kind of stent-like devices with higher metal coverage rate, and it is deployed endovascularly to treat cerebral aneurysms, especially to treat giant aneurysms. However, there exist some arguments about its safety and efficacy. Hemodynamics is considered to play very important role during the initiation, growth and rupture of cerebral aneurysms. In this study, the models of a giant cerebral aneurysm involved a small branch at the aneurysmal sac before and after flow diverter implantation were constructed by virtual deployment, the blood flows in the models were simulated by computational fluid dynamics method. Analyzing the variations of the hemodynamics, the following conclusions were summarized. The flow diverter is very effective device to occlude the aneurysm, the flow rate at the small branch was rarely changed when the flow diverter deployed and the flow diverter.
authors.affiliation: Department of Mechanics and Engineering Science, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors.forename: Shengzhang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Mechanics and Engineering Science, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.affiliation: Beijing Neurosurgery Institute, 6 Tiantan Xili, Beijing 100050, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Beijing Neurosurgery Institute, 6 Tiantan Xili, Beijing 100050, China.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Yang
authors.affiliation: Beijing Neurosurgery Institute, 6 Tiantan Xili, Beijing 100050, China.
authors.forename: Shiqing
authors.initials: S
authors.lastname: Mu
authors.affiliation: Department of Dermatology, Minghang District Central Hospital, 170 Xinsong Road, Shanghai 201199, China.
authors.forename: Wuqing
authors.initials: W
authors.lastname: Wang
mesh_terms: D017542:Aneurysm, Ruptured / Q000503:physiopathology* / Q000601:surgery*; D001783:Blood Flow Velocity; D001807:Blood Vessel Prosthesis; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D017076:Computer-Aided Design; D057510:Endovascular Procedures / Q000295:instrumentation / Q000379:methods; D019544:Equipment Failure Analysis / Q000379:methods; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000601:surgery*; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D017755:Prosthesis Fitting / Q000379:methods; D019919:Prosthesis Implantation / Q000379:methods; D015607:Stents; D016896:Treatment Outcome
keywords: Cerebral aneurysm; flow diverter; hemodynamics; numerical simulation; virtual deployment