title: Inhalation of Polychlorinated Biphenyls (PCB) Produces Hyperactivity in Rats.
abstract: Attention deficit hyperactivity disorder (ADHD) is a serious behavioral syndrome seen in children, and more common in males than females. There is increasing evidence that prenatal and/or early life exposure to persistent organic pollutants (POP) such as polychlorinated biphenyls (PCB) is associated with increased risk of ADHD occurrence. While PCB exposure is usually attributed to ingestion of contaminated food, recent reports of elevated PCB concentrations in indoor air, especially in schools, raised concern regarding inhalation as an important route of exposure to PCB with consequent effects on neurobehavior. The effects of exposure to air contaminated with Aroclor 1248 or contaminated sediment (SED) from the St. Lawrence River were examined on operant behavior of male and female Sprague-Dawley rats. Data showed that relative to controls, vapor-phase inhalation of PCB, whether from blowing air over Aroclor 1248 or from blowing air over sediment contaminated with PCB, resulted in hyperactivity and impatience in rats, more pronounced in males than females. These results are consistent with the hypothesis that inhalation of PCB may contribute to behavioral abnormalities in children.
authors.affiliation: a Department of Psychology , SUNY College at Cortland , Cortland , New York , USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Lombardo
authors.affiliation: a Department of Psychology , SUNY College at Cortland , Cortland , New York , USA.
authors.forename: David F
authors.initials: DF
authors.lastname: Berger
authors.affiliation: b Cortland , New York , USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Hunt
authors.affiliation: c Institute for Health and the Environment, University at Albany , Rensselaer , New York , USA.
authors.forename: David O
authors.initials: DO
authors.lastname: Carpenter
mesh_terms: D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000139:chemically induced / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D019015:Geologic Sediments / Q000737:chemistry; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced* / Q000503:physiopathology; D019570:Inhalation Exposure; D008297:Male; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls