title: Efficient Synthesis of Cladribine via the Metal-Free Deoxygenation.
abstract: The efficient synthesis of cladribine via the metal-free deoxygenation was developed. Using (Bu4N)2S2O8/HCO2Na instead of Bu3SnH/AIBN as deoxygenation system, cladribine could be obtained with good yield and even on tens of grams scales. The intermediates and product could be purified by simple work-up process and chromatography was avoided, which showed the good future for industrial applications.
authors.affiliation: a Department of Chemistry and Chemical Engineering, Xinxiang University , Xinxiang City , Henan Province , P. R. China.
authors.forename: Ran
authors.initials: R
authors.lastname: Xia
authors.affiliation: a Department of Chemistry and Chemical Engineering, Xinxiang University , Xinxiang City , Henan Province , P. R. China.
authors.forename: Lei-Shan
authors.initials: LS
authors.lastname: Chen
mesh_terms: D060326:Chemistry Techniques, Synthetic; D017338:Cladribine / Q000138:chemical synthesis*
chemical_list: D017338:Cladribine
keywords: Cladribine; deoxygenation; metal-free; nucleoside synthesis