title: Generally applicable limits on intakes of uranium based on its chemical toxicity and the radiological significance of intakes at those limits.
abstract: Uranium is chemically toxic and radioactive, and both considerations have to be taken into account when limiting intakes of the element, in the context of both occupational and public exposures. Herein, the most recent information available on the chemical toxicity and biokinetics of uranium is used to propose new standards for limiting intakes of the element. The approach adopted allows coherent standards to be set for ingestion and inhalation of different chemical forms of the element by various age groups. It also allows coherent standards to be set for occupational and public exposures (including exposures of different age groups) and for various exposure regimes (including short-term and chronic exposures). The proposed standards are more restrictive than those used previously, but are less restrictive than the Minimal Risk Levels proposed recently by the US Agency for Toxic Substances and Disease Registry. Having developed a set of proposed limits based solely on chemical toxicity considerations, the radiological implications of exposure at those proposed limits are investigated for natural, depleted and enriched uranium.
authors.affiliation: Mike Thorne and Associates Limited, Quarry Cottage, Hamsterley, Bishop Auckland, County Durham, DL13 3NJ, UK.
authors.forename: M C
authors.initials: MC
authors.lastname: Thorne
authors.forename: J
authors.initials: J
authors.lastname: Wilson
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000706:statistics & numerical data*; D013997:Time Factors; D014501:Uranium / Q000633:toxicity*
chemical_list: D014501:Uranium