title: A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment.
abstract: New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701, South Korea.|Department of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, CMRI, School of Medicine, Kyungpook National University, Daegu, 700-422, South Korea.
authors.forename: Wonhwa
authors.initials: W
authors.lastname: Lee
authors.affiliation: Department of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, CMRI, School of Medicine, Kyungpook National University, Daegu, 700-422, South Korea.
authors.forename: Junyoung
authors.initials: J
authors.lastname: Seo
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701, South Korea.
authors.forename: Soyoung
authors.initials: S
authors.lastname: Kwak
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701, South Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Park
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701, South Korea.
authors.forename: Dong Hee
authors.initials: DH
authors.lastname: Na
authors.affiliation: Department of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, CMRI, School of Medicine, Kyungpook National University, Daegu, 700-422, South Korea.
authors.forename: Soyoun
authors.initials: S
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701, South Korea.
authors.forename: You Mie
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, 136-791, South Korea.|KU-KIST School, Korea University, Seoul, 136-701, South Korea.
authors.forename: In-San
authors.initials: IS
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701, South Korea.|Department of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, CMRI, School of Medicine, Kyungpook National University, Daegu, 700-422, South Korea.
authors.forename: Jong-Sup
authors.initials: JS
authors.lastname: Bae
mesh_terms: D015055:1-Carboxyglutamic Acid / Q000737:chemistry; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry; D017364:Collagenases / Q000378:metabolism; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D005293:Ferritins / Q000737:chemistry; D005312:Fetal Blood; D000066449:Human Embryonic Stem Cells; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D008070:Lipopolysaccharides; D008297:Male; D008810:Mice, Inbred C57BL; D049329:Nanostructures / Q000737:chemistry; D010446:Peptide Fragments / Q000008:administration & dosage*; D011486:Protein C / Q000008:administration & dosage* / Q000737:chemistry; D044463:Receptor, PAR-1 / Q000378:metabolism; D018179:Receptors, Thrombin / Q000819:agonists*; D018805:Sepsis / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D010446:Peptide Fragments; D011486:Protein C; D044463:Receptor, PAR-1; D018179:Receptors, Thrombin; D015055:1-Carboxyglutamic Acid; D005293:Ferritins; D017364:Collagenases
keywords: PC-gla; TRAP; ferritin; nanoparticles; sepsis