title: A Novel Bone Marrow Stimulation Technique Augmented by Administration of Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model.
abstract: Cartilage injuries are a common health problem resulting in the loss of daily activities. Bone marrow stimulation technique, one of the surgical techniques for the cartilage injuries, is characterized by technical simplicity and less invasiveness. However, it has been shown to result in fibrous or fibrocartilaginous repair with inferior long-term results. This study focused on using ultrapurified alginate gel (UPAL gel) as an adjuvant scaffold in combination with a bone marrow stimulation technique. The objective of this study was to assess the efficacy of a bone marrow stimulation technique augmented by UPAL gel in a rabbit osteochondral defect model. To achieve this goal, three experimental groups were prepared as follows: defects without intervention, defects treated with a bone marrow stimulation technique, and defects treated with a bone marrow stimulation technique augmented by UPAL gel. The macroscopic and histological findings of the defects augmented by UPAL gel improved significantly more than those of the others at 16 weeks postoperatively. The combination technique elicited hyaline-like cartilage repair, unlike bone marrow stimulation technique alone. This combination procedure has the potential of improving clinical outcomes after use of a bone marrow stimulation technique for articular cartilage injuries.
authors.affiliation: 1 Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan .
authors.forename: Rikiya
authors.initials: R
authors.lastname: Baba
authors.affiliation: 1 Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan .
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Onodera
authors.affiliation: 1 Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan .
authors.forename: Daisuke
authors.initials: D
authors.lastname: Momma
authors.affiliation: 1 Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan .
authors.forename: Masatake
authors.initials: M
authors.lastname: Matsuoka
authors.affiliation: 1 Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan .
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Hontani
authors.affiliation: 1 Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan .
authors.forename: Sameh
authors.initials: S
authors.lastname: Elmorsy
authors.affiliation: 1 Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan .
authors.forename: Kaori
authors.initials: K
authors.lastname: Endo
authors.affiliation: 2 Division of Human Mechanical Systems and Design, Faculty of Engineering, Hokkaido University , Sapporo, Japan .
authors.forename: Masahiro
authors.initials: M
authors.lastname: Todoh
authors.affiliation: 2 Division of Human Mechanical Systems and Design, Faculty of Engineering, Hokkaido University , Sapporo, Japan .
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tadano
authors.affiliation: 1 Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine , Sapporo, Japan .
authors.forename: Norimasa
authors.initials: N
authors.lastname: Iwasaki
mesh_terms: D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D002358:Cartilage, Articular / Q000293:injuries* / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D005782:Gels / Q000494:pharmacology; D020723:Glucuronic Acid / Q000494:pharmacology; D006603:Hexuronic Acids / Q000494:pharmacology; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects*; D054457:Tissue Scaffolds
chemical_list: D000464:Alginates; D005782:Gels; D006603:Hexuronic Acids; D020723:Glucuronic Acid