title: Chemically modified tetracyclines: The novel host modulating agents.
abstract: Periodontal pathogens and destructive host responses are involved in the initiation and progression of periodontitis. The emergence of host response modulation as a treatment concept has resulted from our improved understanding of the pathogenesis of periodontal disease. A variety of drugs have been evaluated as host modulation agents (HMA), including Non Steroidal Anti Inflammatory Drugs (NSAIDS), bisphosphonates, tetracyclines, enamel matrix proteins and bone morphogenetic proteins. Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property. The CMTs are designed to be more potent inhibitors of pro inflammatory mediators and can increase the levels of anti inflammatory mediators.
authors.affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Devulapalli Narasimha
authors.initials: DN
authors.lastname: Swamy
authors.affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Sahitya
authors.initials: S
authors.lastname: Sanivarapu
authors.affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Moogla
authors.affiliation: Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Vasavi
authors.initials: V
authors.lastname: Kapalavai
keywords: Anti-collagenolytic property; chemically modified tetracyclines; host modulation; matrix metalloproteinases; tetracycline