title: Synthesis and antibacterial activity of a new derivative of the Meldrun acid: 2,2-dimethyl-5-(4H-1,2,4-triazol-4-ylaminomethylene)-1,3-dioxane-4,6-dione (C9H10N4O4).
abstract: The discovery of new substances with proven antimicrobial activity is the current study goal of various researchers. Usage of synthetic products has grown considerably in the past few years due to processing agility, and capability of going through previous chemical modifications in order to enhance its biological activity. Widespread careless use of antimicrobials has made the number of resistant microorganisms rise significantly, thus demanding more efficient drugs to fight them. One of these synthetic candidates for this purpose is the substance 2,2-Dimethyl-5-(4H-1,2,4-triazol-4-ylaminomethylene)-1,3-dioxane-4,6-dione (C9H10N4O4), aminomethylene derivative from Meldrum's acid. This substance, alone and in association with common antibiotics, were evaluated in vitro for antimicrobial activity, and had their minimum inhibitory concentration (MIC) towards Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 10536 and Pseudomonas aeruginosa ATCC 15442, as well as multiresistant strains Escherichia coli 27, Staphylococcus aureus 358 and Pseudomonas aeruginosa 03 determined. The antimicrobial modulation action tests of the aminoglycosides with C9H10N4O4 were performed according to the microdilution method, and resulted in observation of a positive synergic effect.
authors.affiliation: Mestrado em Bioprospecção Molecular.
authors.forename: Gillena M M
authors.initials: GM
authors.lastname: Sampaio
authors.affiliation: Mestrado em Bioprospecção Molecular ; Departamento de Física.
authors.forename: Alexandre M R
authors.initials: AM
authors.lastname: Teixeira
authors.affiliation: Mestrado em Bioprospecção Molecular ; Departamento de Química Biológica, Universidade Regional do Cariri, 63010-970, Brasil.
authors.forename: Henrique D M
authors.initials: HD
authors.lastname: Coutinho
authors.affiliation: Mestrado em Bioprospecção Molecular ; Departamento de Física.
authors.forename: Diniz M
authors.initials: DM
authors.lastname: Sena Junior
authors.affiliation: Departamento de Física, Universidade Federal do Ceará, 60455-760, Brasil.
authors.forename: Paulo T C
authors.initials: PT
authors.lastname: Freire
authors.affiliation: Departamento de Física, Universidade Federal de Mato Grosso, 78060-900, Brasil.
authors.forename: Ricardo R F
authors.initials: RR
authors.lastname: Bento
authors.affiliation: Setor Litoral - Universidade Federal do Paraná, Matinhos, 83260-000, Brasil.
authors.forename: Luiz E
authors.initials: LE
authors.lastname: Silva
keywords: Escherichia coli; Pseudomonas aeruginosa; Staphylococcus aureus; aminoglycosides; antimicrobial activity; resistant microorganisms; synthetic products