title: Influence of Polymorphism (-G308A) TNF-α on the Periportal Fibrosis Regression of Schistosomiasis After Specific Treatment.
abstract: OBJECTIVE
  Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine and important mediator of severity for periportal fibrosis (PPF). We hypothesized that the (-G380A) polymorphism in the TNF-α gene is associated with regression of PPF after treatment for schistosomiasis mansoni.
  
  
  METHODS
  This is a retrospective cohort study, involving 124 Brazilian patients infected with Schistosoma mansoni, who were followed for 2 years after treatment to estimate the likelihood of PPF regression. Sociodemographic and clinical factors were also identified, with emphasis on specific treatment.
  
  
  RESULTS
  No statistical difference was observed between sociodemographic and clinical factors among the exposed groups. Genotypes (-308) GA/AA were positively associated with the degree of PFF regression (relative risk [RR] = 0.52; ρ = 0.025), as well as in the image pattern of PPF (RR = 0.56; ρ = 0.048), when compared with the genotype (-308) GG. There was no statistical difference in TNF-α serum levels between the exposed groups.
  
  
  CONCLUSIONS
  These results suggest that the (-G308A) polymorphism of the TNF-α gene may be one of the factors that prevents the regression of the degree and pattern of PPF in the Brazilian population, and thus it may potentially be a predictive factor of PPF intensity in schistosomiasis.
authors.affiliation: 1 Gastroenterologia, Hospital das Clínicas , Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil .
authors.forename: Juliana B
authors.initials: JB
authors.lastname: Oliveira
authors.affiliation: 2 Centro Acadêmico de Vitória, Universidade Federal de Pernambuco , Vitória de Santo Antão, Pernambuco, Brazil .|3 Laboratório de Biologia Molecular, Centro de Oncohematologia Pediátrica, Hospital Universitário Oswaldo Cruz , Universidade de Pernambuco, Recife, Pernambuco, Brazil .
authors.forename: Paula C V
authors.initials: PC
authors.lastname: Silva
authors.affiliation: 2 Centro Acadêmico de Vitória, Universidade Federal de Pernambuco , Vitória de Santo Antão, Pernambuco, Brazil .
authors.forename: Leticia M
authors.initials: LM
authors.lastname: Vasconcelos
authors.affiliation: 3 Laboratório de Biologia Molecular, Centro de Oncohematologia Pediátrica, Hospital Universitário Oswaldo Cruz , Universidade de Pernambuco, Recife, Pernambuco, Brazil .|4 Instituto de Ciências Biológicas, Universidade de Pernambuco , Recife, Pernambuco, Brazil .
authors.forename: Adriana V
authors.initials: AV
authors.lastname: Gomes
authors.affiliation: 5 Setor de Virologia do Laboratório de Imunopatologia Keizo-Asami (LIKA), Universidade Federal de Pernambuco , Recife, Pernambuco, Brazil .|6 Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco , Recife, Pernambuco, Brazil .
authors.forename: Maria Rosãngela C D
authors.initials: MR
authors.lastname: Coêlho
authors.affiliation: 5 Setor de Virologia do Laboratório de Imunopatologia Keizo-Asami (LIKA), Universidade Federal de Pernambuco , Recife, Pernambuco, Brazil .
authors.forename: Georgea G O M
authors.initials: GG
authors.lastname: Cahu
authors.affiliation: 3 Laboratório de Biologia Molecular, Centro de Oncohematologia Pediátrica, Hospital Universitário Oswaldo Cruz , Universidade de Pernambuco, Recife, Pernambuco, Brazil .|4 Instituto de Ciências Biológicas, Universidade de Pernambuco , Recife, Pernambuco, Brazil .|7 Faculdade de Ciências Médicas, Universidade de Pernambuco , Recife, Pernambuco, Brazil .
authors.forename: Maria Tereza Cartaxo
authors.initials: MT
authors.lastname: Muniz
authors.affiliation: 8 Departamento de Medicina Clínica, Universidade Federal de Pernambuco , Recife, Pernambuco, Brazil .
authors.forename: Ana Lúcia C
authors.initials: AL
authors.lastname: Domingues
mesh_terms: D000368:Aged; D000818:Animals; D015331:Cohort Studies; D005355:Fibrosis; D005838:Genotype; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000235:genetics* / Q000469:parasitology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D012307:Risk Factors; D012550:Schistosoma mansoni / Q000302:isolation & purification; D012552:Schistosomiasis / Q000097:blood / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha