title: Evaluating relationship in cytokines level, Fibromyalgia Impact Questionnaire and Body Mass Index in women with Fibromyalgia syndrome.
abstract: Cytokines (TNF-α and IL-6) levels are reported to be perturbed in Fibromyalgia syndrome (FMS) patients. Moreover, Body Mass Index (BMI) may also be related to disturbed cytokines level. Therefore, the present study was planned to evaluate the levels of cytokines and to correlate them with BMI and Fibromyalgia Impact Questionnaire Revised (FIQR) in female FMS patients (n= 60) and control group (n= 60). 4 ml of blood samples were taken from both the group of patients and controls to measure the levels of IL-6 and TNF-α . Symptoms of FMS were assessed by FIQR. BMI was calculated by a standard formula of weight in kilograms divided by height in meter square. There were significant differences in BMI levels in FMS patients than in control group. However, no significant association was found between BMI and TNF-α levels, and BMI and IL-6 levels in patient and control groups. However, a significant association was found between FIQR and BMI in patients group. On the basis of the results we conclude that the levels of IL-6 and TNF-alpha are not associated with BMI in FMS patients. Furthermore, patients with higher BMI may fall at the risk of FMS. Therefore, weight management may be an important aspect for treatment of FMS patients.
authors.affiliation: Department of Rheumatology, King George's Medical University, Lucknow, India.
authors.forename: Fatima
authors.initials: F
authors.lastname: Ghizal
authors.affiliation: Department of Rheumatology, King George's Medical University, Lucknow, India.
authors.forename: Siddharth Kumar
authors.initials: SK
authors.lastname: Das
authors.affiliation: Department of Physiology, King George's Medical University, Lucknow, India.
authors.forename: Narsingh
authors.initials: N
authors.lastname: Verma
authors.affiliation: Department of Biochemistry, King George's Medical University, Lucknow, India.
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Mahdi
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D004185:Disability Evaluation; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D011795:Surveys and Questionnaires; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
keywords: Fibromyalgia syndrome; body mass index; interleukin-6; tumor necrosis factor-alpha