title: Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?
abstract: Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. Specifically, we describe the processes that generate such imbalances at the molecular level, and try to understand how they affect protein folding and localization. Overall, current knowledge suggests that microglia pro-inflammatory mediators can generate membrane damage, which may have an impact in terms of triggering or accelerating disease manifestation.
authors.affiliation: Laboratory of Molecular Biology (Medical Research Council), Francis Crick Avenue, Cambridge, CB2 0QH, UK. nsdgroot@mrc-lmb.cam.ac.uk.|Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. nsdgroot@mrc-lmb.cam.ac.uk.
authors.forename: Natalia Sánchez
authors.initials: NS
authors.lastname: de Groot
authors.affiliation: Laboratory of Molecular Biology (Medical Research Council), Francis Crick Avenue, Cambridge, CB2 0QH, UK. marc.torrent@vhir.org.|Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. marc.torrent@vhir.org.|Vall d'Hebron Research Institute (VHIR), Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain. marc.torrent@vhir.org.
authors.forename: Marc Torrent
authors.initials: MT
authors.lastname: Burgas
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism / Q000473:pathology; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D006706:Homeostasis; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism / Q000473:pathology; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology*; D010300:Parkinson Disease / Q000473:pathology; D066263:Protein Aggregation, Pathological; D015398:Signal Transduction
keywords: Membrane; Microglia; Neurodegenerative disease; Neuroinflammation; Protein aggregation