title: Using Small Molecules to Dissect Non-apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis.
abstract: Genetically programmed cell death is a universal and fundamental cellular process in multicellular organisms. Apoptosis and necroptosis, two common forms of programmed cell death, play vital roles in maintenance of homeostasis in metazoans. Dysfunction of the regulatory machinery of these processes can lead to carcinogenesis or autoimmune diseases. Inappropriate death of essential cells can lead to organ dysfunction or even death; ischemia-reperfusion injury and neurodegenerative disorders are examples of this. Recently, novel forms of non-apoptotic programmed cell death have been identified. Although these forms of cell death play significant roles in both physiological and pathological conditions, the detailed molecular mechanisms underlying them are still poorly understood. Here, we discuss progress in using small molecules to dissect three forms of non-apoptotic programmed cell death: necroptosis, ferroptosis, and pyroptosis.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and, Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center and, Peking-Tsinghua Center for Life Sciences, Peking University, 202 Cheng Fu Road, Beijing, 100871, China.|National Institute of Biological Sciences (NIBS), No 7 Life Science Road, Zhong Guan Cun Life Science Park, Beijing, 102206, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Dong
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and, Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center and, Peking-Tsinghua Center for Life Sciences, Peking University, 202 Cheng Fu Road, Beijing, 100871, China.
authors.forename: Daohong
authors.initials: D
authors.lastname: Liao
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and, Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center and, Peking-Tsinghua Center for Life Sciences, Peking University, 202 Cheng Fu Road, Beijing, 100871, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Liu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and, Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center and, Peking-Tsinghua Center for Life Sciences, Peking University, 202 Cheng Fu Road, Beijing, 100871, China. xglei@pku.edu.cn.|National Institute of Biological Sciences (NIBS), No 7 Life Science Road, Zhong Guan Cun Life Science Park, Beijing, 102206, China. xglei@pku.edu.cn.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Lei
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009336:Necrosis; D000069292:Pyroptosis / Q000187:drug effects; D011810:Quinoxalines / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology
chemical_list: D011810:Quinoxalines; D054852:Small Molecule Libraries; D013141:Spiro Compounds; C000595890:liproxstatin-1
keywords: cancer; ferroptosis; necroptosis; programmed cell death; pyroptosis; signal transduction