title: Factors associated with reclassification of hyperplastic polyps after pathological reassessment from screening and surveillance colonoscopies.
abstract: BACKGROUND
  A substantial interobserver variation in the differential diagnosis of hyperplastic polyps (HPs) and sessile or traditional serrated adenomas (SSAs/TSAs) has been described.
  
  
  METHODS
  The aim of this study is to determine the magnitude of reclassification of HPs and associated factors after pathological reassessment of specimens from screening and surveillance colonoscopies, and to estimate its consequences for follow-up recommendations.
  
  
  RESULTS
  Among 1694 screening and surveillance colonoscopies, a total of 536 polyps were initially diagnosed as HPs and remained unchanged in 88.5% (n = 474), whereas 7.6 (n = 41) and 1.1% (n = 6) were reclassified as SSA and TSA, respectively. Compared to definite HPs, SSAs were found more frequently in men than in women (82.9 vs. 61.2%, p < 0.05), and in individuals ≥65.0 years (51.2 vs. 31.6%, p = 0.05). Also, more SSAs were >5 mm in size (36.6 vs. 6.3%, p < 0.05) and were localized in the proximal colon (31.7 vs. 11.8%, p < 0.05). In a mixed model analysis, age ≥65.0 years (OR 4.13, 95% CI 1.22-14.2), snare polypectomy (OR 23.6, 95% CI 4.86-115), and coincident advanced adenomas (OR 7.56, 95% CI 1.31-43.5) were significantly (p < 0.05) associated with reclassification to SSAs. Only 0.53% of patients had received false recommendations for follow-up visits based on the incorrect HP diagnosis. A c.1799T>A, p.V600E BRAF mutation was detected in 21.9 % (n = 9) of reclassified SSAs.
  
  
  CONCLUSIONS
  Considering these factors may be helpful in serrated lesions that are difficult to allocate. Incorrect recommendations regarding control colonoscopy intervals due to misdiagnosed HPs can explain only a small fraction of interval colorectal cancers.
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Schramm
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Kaiser
authors.affiliation: Center for Pathology, University Hospital of Cologne, Cologne, Germany.
authors.forename: Uta
authors.initials: U
authors.lastname: Drebber
authors.affiliation: Institute for Pathology, University Hospital of Muenster, Muenster, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Gruenewald
authors.affiliation: Institute for Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Franklin
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Kuetting
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bowe
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
authors.forename: Vera
authors.initials: V
authors.lastname: Hoffmann
authors.affiliation: Center for Pathology, University Hospital of Cologne, Cologne, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Gatzke
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Toex
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. hans-michael.steffen@uk-koeln.de.
authors.forename: Hans-Michael
authors.initials: HM
authors.lastname: Steffen
mesh_terms: D000236:Adenoma / Q000145:classification* / Q000473:pathology*; D000368:Aged; D003110:Colonic Neoplasms / Q000145:classification* / Q000473:pathology*; D003111:Colonic Polyps / Q000145:classification* / Q000473:pathology*; D003113:Colonoscopy; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged
keywords: Reclassification; Screening colonoscopy; Sessile serrated adenomas