title: Effect of blood vessels on light distribution in optogenetic stimulation of cortex.
abstract: In this Letter, the impact of blood vessels on light distribution during photostimulation of cortical tissue in small rodents is investigated. Brain optical properties were extracted using a double-integrating sphere setup, and optical coherence tomography was used to image cortical vessels and capillaries to generate a three-dimensional angiogram of the cortex. By combining these two datasets, a complete volumetric structure of the cortical tissue was developed and linked to a Monte Carlo code which simulates light propagation in this inhomogeneous structure and illustrates the effect of blood vessels on the penetration depth and pattern preservation in optogenetic stimulation.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Azimipour
authors.forename: Farid
authors.initials: F
authors.lastname: Atry
authors.forename: Ramin
authors.initials: R
authors.lastname: Pashaie
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000528:radiation effects*; D001921:Brain / Q000098:blood supply* / Q000378:metabolism / Q000528:radiation effects; D008027:Light; D009010:Monte Carlo Method; D062308:Optogenetics; D051381:Rats; D041623:Tomography, Optical Coherence