title: Generalised fibrotic gingival enlargement in a psoriatic patient: an association or a coincidence?
abstract: Gingival ﬁbromatosis is a rare, benign, slow progressive fibrous overgrowth of gingiva, with great genetic and clinical heterogeneity. It can be inherited as an isolated trait (hereditary/idiopathic gingival ﬁbromatosis), and/or as a component of a syndrome. We report a case of a young girl suffering from psoriasis who also presented with an unusual generalised idiopathic gingival fibromatosis. Psoriasis, a chronic inflammatory skin disease, of multifactorial origin, is characterised by keratinocyte hyperproliferation, dedifferentiation, neoangiogenesis and inflammation. T cell-mediated immunity is considered to be the key element in the disease process. The existence of oral mucosal alterations in patients with psoriasis is a controversial topic, as histopathological correlations are not clearly evident, and oral and cutaneous lesions do not follow a parallel course. However, this article highlights a possible association of T-lymphocyte stimulation inducing fibroblasts to undergo epidermal hyperproliferation and increased collagen production in the gingiva, which in turn may be responsible for inducing gingival hyperplasia.
authors.affiliation: Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.
authors.forename: Smitha Rani
authors.initials: SR
authors.lastname: Thada
authors.affiliation: Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.
authors.forename: Ravindranath
authors.initials: R
authors.lastname: Vineetha
authors.affiliation: Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India.
authors.forename: Keerthilatha M
authors.initials: KM
authors.lastname: Pai
mesh_terms: D000328:Adult; D003094:Collagen / Q000378:metabolism; D005260:Female; D005351:Fibromatosis, Gingival / Q000175:diagnosis* / Q000209:etiology; D005885:Gingival Hyperplasia / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007111:Immunity, Cellular; D011565:Psoriasis / Q000150:complications*
chemical_list: D003094:Collagen