title: A Vulnerable Side to MYC-Driven Cancers.
abstract: Although aberrant MYC activity confers protumorigenic effects on cancer cells, it also adds stress by increasing the amount of pre-mRNA substrates for the spliceosome to process. New research indicates that MYC-driven cancers depend on an intact, functional spliceosome for survival; targeting this multiprotein complex could therefore be an indirect therapeutic strategy against a highly drug-resistant oncogene.
mesh_terms: D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism
chemical_list: D016271:Proto-Oncogene Proteins c-myc