title: Biochemical Screening for in utero Drug Exposure.
abstract: Licit and illicit drug use is a common complication of pregnancy. Accurate information on drug use is difficult to obtain for many reasons as women fear self-disclosure or consenting for drug testing due to stigma, guilt, and fear of social and legal harm. As information about drug use is clinically very important, biochemical testing is an important adjunct to careful maternal history. In addition, research studies depend on accurate measures of exposure when reporting risks of a substance. This paper delineates available matrices for and methods of biochemical drug testing in pregnant women and neonates.
authors.affiliation: Department of Obstetrics, Gynecology and Women's Health University of Hawaii John A. Burns School of Medicine, 1319 Punahou St., Ste 824, Honolulu, HI 96826, USA. tewright@hawaii.edu.
authors.forename: Tricia E
authors.initials: TE
authors.lastname: Wright
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects / Q000378:metabolism*; D000653:Amniotic Fluid / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000652:urine; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism; D006197:Hair / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure / Q000009:adverse effects; D008431:Maternal-Fetal Exchange; D008470:Meconium / Q000378:metabolism; D010920:Placenta / Q000098:blood supply / Q000378:metabolism; D021041:Placental Circulation; D011237:Predictive Value of Tests; D011247:Pregnancy; D018570:Risk Assessment; D012463:Saliva / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects / Q000378:metabolism*; D015813:Substance Abuse Detection / Q000379:methods*; D019966:Substance-Related Disorders / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D013542:Sweat / Q000378:metabolism; D016482:Urinalysis
chemical_list: D015415:Biomarkers