title: Glyceryl trinitrate for the treatment of preterm labor.
abstract: OBJECTIVE
  This study was conducted to compare the tocolytic efficacy of glyceryltrinitrate (GTN) with that of magnesium sulfate (MgSO4) and to investigate serum nitric oxide metabolites before and after tocolysis.
  
  
  METHODS
  In total, 48 women between 27 and 34 weeks' gestation with threatened preterm labor and intact membranes were randomly allocated to receive either GTN or MgSO4 tocolysis. Main outcome measures included tocolytic efficacy and maternal side effect(s) of the tocolytic agent. Obstetric and neonatal outcomes as well as pretreatment and posttreatment nitric oxide (NO) metabolites were assessed.
  
  
  RESULTS
  Forty-one patients were included into the final analysis. Uterine contraction cessation times were 3.66±1.28 and 6.83±3.47 hours for GTN and MgSO4 groups, respectively. Similarly, maternal side effects were significantly lower in the GTN group than in the MgSO4 group, and no serious maternal side effects were recorded. Serum NO metabolite levels before treatment were significantly lower in the treatment groups than in the controls. Serum nitrite levels were significantly increased after tocolytic treatment both in MgSO4 and GTN groups.
  
  
  CONCLUSIONS
  GTN effectively delays preterm delivery and reduces neonatal morbidity and mortality with less maternal side effects and seems to be an effective and safe alternative to MgSO4.
authors.affiliation: Clinic of Obstetrics and Gynecology, Nazilli State Hospital, Aydın, Turkey.
authors.forename: Şafak
authors.initials: Ş
authors.lastname: Çalışkan
authors.affiliation: Department of Obstetrics and Gynecology, Erzincan University Faculty of Medicine, Erzincan, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Narin
authors.affiliation: Clinic of Obstetrics and Gynecology, Etlik Zübeyde Hanım Training and Research Hospital Ankara, Turkey.
authors.forename: Faruk Suat
authors.initials: FS
authors.lastname: Dede
authors.affiliation: Clinic of Obstetrics and Gynecology, Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Raziye
authors.initials: R
authors.lastname: Narin
authors.affiliation: Clinic of Obstetrics and Gynecology, Zekai Tahir Burak Training and Research Hospital, Ankara, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Dede
authors.affiliation: Clinic of Obstetrics and Gynecology, Etlik Zübeyde Hanım Training and Research Hospital Ankara, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Kandemir
keywords: Glyceryl trinitrate; magnesium sulfate; nitric oxide; tocolysis