title: Enzymatically Cleavable siRNA Prodrugs: a New Paradigm for the Intracellular Delivery of RNA-Based Therapeutics.
abstract: Prodrugs enlarged: An unprecedented synthesis of enzymatically cleavable siRNA prodrugs ("siRNN") has recently been reported. Targeting domain (TD)-functionalized siRNN released the parent siRNA after cellular uptake and triggered the RNA interference mechanism both in vitro and in vivo. The highlighted report could pave the way for prodrug-based approaches to overcome delivery-related limitations of nucleic acid therapeutics.
authors.affiliation: Pharmaceutical and Medicinal Chemistry, Department of Pharmacy, Saarland University, Campus C2 3, 66123 Saarbrücken (Germany). christian.ducho@uni-saarland.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Ducho
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D004798:Enzymes / Q000378:metabolism*; D015394:Molecular Structure; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D034741:RNA, Small Interfering / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D004798:Enzymes; D011355:Prodrugs; D034741:RNA, Small Interfering
keywords: RNA interference; drug delivery; oligonucleotides; prodrugs; siRNA