title: Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995-2011.
abstract: There is warranted interest in assessing the association between residential radon exposure and the risk of childhood cancer. We sought to evaluate the association between residential radon exposure and the incidence of childhood lymphoma in Texas. The Texas Cancer Registry (n = 2147) provided case information for the period 1995-2011. Denominator data were obtained from the United States Census. Regional arithmetic mean radon concentrations were obtained from the Texas Indoor Radon Survey and linked to residence at diagnosis. Exposure was assessed categorically: ≤25th percentile (reference), >25th to ≤50th percentile, >50th to ≤75th percentile, and >75th percentile. Negative binomial regression generated adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI). We evaluated lymphoma overall and by subtype: Hodgkin (HL; n = 1248), Non-Hodgkin excluding Burkitt (non-BL NHL; n = 658), Burkitt (BL; n = 241), and Diffuse Large B-cell (DLBCL; n = 315). There was no evidence that residential radon exposure was positively associated with lymphoma overall, HL, or BL. Areas with radon concentrations >75th percentile had a marginal increase in DLBCL incidence (aIRR = 1.73, 95% CI: 1.03-2.91). In one of the largest studies of residential radon exposure and the incidence of childhood lymphoma, we found little evidence to suggest a positive or negative association; an observation consistent with previous studies.
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA. Erin.Peckham@bcm.edu.
authors.forename: Erin C
authors.initials: EC
authors.lastname: Peckham
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA. Scheurer@bcm.edu.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Scheurer
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA. Danysh@bcm.edu.
authors.forename: Heather E
authors.initials: HE
authors.lastname: Danysh
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA. Lubega@bcm.edu.
authors.forename: Joseph
authors.initials: J
authors.lastname: Lubega
authors.affiliation: Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, MC 1964, P.O. Box 149347, Austin, TX 78714-9347, USA. Peter.Langlois@dshs.state.tx.us.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Langlois
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS BCM305, Houston, TX 77030, USA. Philip.Lupo@bcm.edu.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Lupo
mesh_terms: D000293:Adolescent; D000328:Adult; D000396:Air Pollutants, Radioactive / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006798:Housing; D006801:Humans; D015994:Incidence; D019570:Inhalation Exposure; D008223:Lymphoma / Q000453:epidemiology*; D008297:Male; D011886:Radon / Q000032:analysis*; D012306:Risk; D013781:Texas / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000396:Air Pollutants, Radioactive; D011886:Radon
keywords: Texas Cancer Registry; childhood cancer; epidemiology; lymphoma; residential radon