title: How Do RIM-BPs Link Voltage-Gated Ca(2+) Channels to Evoked Neurotransmitter Release?
abstract: Coupling between voltage-gated Ca(2+) influx and synaptic vesicle exocytosis is essential for rapid evoked neurotransmission. Acuna et al. show that the knockout of RIM-BPs, which are key structural components of this coupling, decreases the reliability of evoked neurotransmitter release.
authors.affiliation: Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
authors.forename: Ying C
authors.initials: YC
authors.lastname: Li
authors.affiliation: Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA. Electronic address: Ege.Kavalali@UTSouthwestern.edu.
authors.forename: Ege T
authors.initials: ET
authors.lastname: Kavalali
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000502:physiology*; D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism*; D020692:rab3 GTP-Binding Proteins / Q000502:physiology*
chemical_list: D018528:ATP-Binding Cassette Transporters; D018377:Neurotransmitter Agents; D020692:rab3 GTP-Binding Proteins; D002118:Calcium