title: Polysaccharide Constituents of Three Types of Sea Urchin Shells and Their Anti-Inflammatory Activities.
abstract: As a source of potent anti-inflammatory traditional medicines, the quantitative chromatographic fingerprints of sea urchin shell polysaccharides were well established via pre-column derivatization high performance liquid chromatography (HPLC) analysis. Based on the quantitative results, the content of fucose and glucose could be used as preliminary distinguishing indicators among three sea urchin shell species. Besides, the anti-inflammatory activities of the polysaccharides from sea urchin shells and their gonads were also determined. The gonad polysaccharide of Anthocidaris crassispina showed the most potent anti-inflammatory activity among all samples tested.
authors.affiliation: Shanghai Medical College, Fudan University, Shanghai 200433, China. 08300240065@fudan.edu.cn.
authors.forename: Heng
authors.initials: H
authors.lastname: Jiao
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, No. 800, Xiangyin Rd., Shanghai 200433, China. 1141531148@qq.com.|School of Life Science and Technology, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China. 1141531148@qq.com.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Shang
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, No. 800, Xiangyin Rd., Shanghai 200433, China. 769948307@qq.com.|School of Life Science and Technology, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China. 769948307@qq.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, No. 800, Xiangyin Rd., Shanghai 200433, China. 781548697@qq.com.|School of Life Science and Technology, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China. 781548697@qq.com.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, No. 800, Xiangyin Rd., Shanghai 200433, China. biolxy@163.com.|Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China. biolxy@163.com.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China. zhengh@cpu.edu.cn.
authors.forename: Heng
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Marine Biopharmaceutical Institute, Second Military Medical University, No. 800, Xiangyin Rd., Shanghai 200433, China. luxiaoling@smmu.edu.cn.|Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China. luxiaoling@smmu.edu.cn.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Lu
mesh_terms: D060105:Animal Shells / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D011134:Polysaccharides / Q000737:chemistry*; D012617:Sea Urchins / Q000737:chemistry* / Q000145:classification
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D011134:Polysaccharides
keywords: anti-inflammatory; high performance liquid chromatography; polysaccharide; quantitative determination; sea urchin