title: Individual differences in the behavioral effects of nicotine: A review of the preclinical animal literature.
abstract: Not everyone who tries tobacco or other nicotine-containing products becomes a long-term user. Certain traits or factors that are differentially present in these individuals must be able to help health care providers and researchers determine who is more likely to become chronic users of nicotine-containing products. Some of these factors, particularly sensation-seeking/novelty, impulsivity, and anxiety, lend themselves to the creation of animal models of reactivity to nicotine. These models of reactivity to nicotine can improve the translational aspects of preclinical animal research on nicotine-induced behaviors and treatments in order to help reduce negative outcomes in human populations. The goal of this review is to evaluate the current status of animal models of individual differences that serve to predict the later behavioral effects of nicotine. The limited utility and inconsistency of existing novelty models is considered, as well as the promise of impulsivity and anxiety models in preclinical animal populations. Finally, other models that could be employed to extend the benefit of the current research are examined.
authors.affiliation: Department of Psychology, Concord University, Athens, WV 24712-1000, United States. Electronic address: amfalco@concord.edu.
authors.forename: Adriana M
authors.initials: AM
authors.lastname: Falco
authors.affiliation: Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, United States.
authors.forename: Rick A
authors.initials: RA
authors.lastname: Bevins
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006801:Humans; D007206:Individuality; D051379:Mice; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D051381:Rats
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine
keywords: Anxiety; Impulsivity; Individual differences; Mice; Nicotine; Novelty; Rats; Sensation-seeking