title: Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer.
abstract: The rise in human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) has elicited significant interest in the role of high-risk HPV in tumorigenesis. Because patients with HPV-positive HNSCC have better prognoses than do their HPV-negative counterparts, current therapeutic strategies for HPV⁺ HNSCC are increasingly considered to be overly aggressive, highlighting a need for customized treatment guidelines for this cohort. Additional issues include the unmet need for a reliable screening strategy for HNSCC, as well as the ongoing assessment of the efficacy of prophylactic vaccines for the prevention of HPV infections in the head and neck regions. This review also outlines a number of emerging prospects for therapeutic vaccines, as well as for targeted, molecular-based therapies for HPV-associated head and neck cancers. Overall, the future for developing novel and effective therapeutic agents for HPV-associated head and neck tumors is promising; continued progress is critical in order to meet the challenges posed by the growing epidemic.
authors.affiliation: Department of Basic Science, Loma Linda University, Loma Linda, CA 92354, USA. sowhang@llu.edu.
authors.forename: Sonia N
authors.initials: SN
authors.lastname: Whang
authors.affiliation: Department of Basic Science, Loma Linda University, Loma Linda, CA 92354, USA. mfilippova@llu.edu.
authors.forename: Maria
authors.initials: M
authors.lastname: Filippova
authors.affiliation: Department of Basic Science, Loma Linda University, Loma Linda, CA 92354, USA. pdhughes@llu.edu.
authors.forename: Penelope
authors.initials: P
authors.lastname: Duerksen-Hughes
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000517:prevention & control / Q000601:surgery*; D055088:Early Detection of Cancer / Q000379:methods*; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000517:prevention & control / Q000601:surgery*; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000517:prevention & control; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000276:immunology; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D053918:Papillomavirus Vaccines
keywords: HNSCC; HPV-related oropharyngeal squamous cell carcinoma; HR HPV; OPSCC; cancer treatments; head and neck squamous cell carcinoma; high risk HPV; target therapy