title: Pharmacokinetics of enrofloxacin in snakehead fish, Channa argus.
abstract: The pharmacokinetics of enrofloxacin (EF) was investigated after single intravenous (i.v.) and oral (p.o.) dose of 10 mg/kg body weight (b.w.) in snakehead fish at 24-26 °C. The plasma concentrations of EF and its metabolite ciprofloxacin (CF) were determined by high-performance liquid chromatography. The plasma concentration-time data were described by an open two-compartment model for both routes. After intravenous administration, the elimination half-life (T1/2β ), area under the concentration-time curve (AUC) and total body clearance of EF were 19.82 h, 75.79 μg h/mL and 0.13 L/h/kg, respectively. Following p.o. administration, the maximum plasma concentration (Cmax ), T1/2β and AUC of EF were 1.86 μg/mL, 35.8 h and 49.98 μg h/mL, respectively. Absorption of EF was good with a bioavailability (F) of 65.82%, which was higher than that calculated in most seawater fish. CF, an active metabolite of EF, was detected occasionally in this study, which indicates a low extent of deethylation of EF in snakehead fish.
authors.affiliation: Department of Economical Animal Sciences and Aquaculture, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: X
authors.initials: X
authors.lastname: Fang
authors.affiliation: Department of Economical Animal Sciences and Aquaculture, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Economical Animal Sciences and Aquaculture, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: X
authors.initials: X
authors.lastname: Liu
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D000077422:Enrofloxacin; D005399:Fishes / Q000097:blood* / Q000378:metabolism; D024841:Fluoroquinolones / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin