title: The Fast Component of Visual Field Decay Rate Correlates With Disc Rim Area Change Throughout the Entire Range of Glaucomatous Damage.
abstract: OBJECTIVE
  We investigated the longitudinal relationships between the changes in neuroretinal rim area (RA) and the slow (SC) and fast (FC) components of visual field (VF) decay at various stages of glaucoma.
  
  
  METHODS
  We divided 465 eyes of 338 patients into glaucoma suspect, and preperimetric, early, and moderate/advanced glaucoma. All patients had a minimum of 3 confocal scanning laser ophthalmoscopic examinations and 4 VF tests with follow-up of 4 or more years. A pointwise exponential regression was used to perform trend analyses on thresholds at each VF test location, which was partitioned into SC and FC. A mixed effects linear model was used to explore the associations of RA change with mean deviation (MD), visual field index (VFI), SC, and FC.
  
  
  RESULTS
  Decreased RA was associated with lower mean threshold sensitivities of FC regardless of baseline severity of glaucoma (P ≤ 0.03). The mean threshold sensitivities in SC were not correlated with RA change at any stage. Decreased RA was correlated with worse MD in preperimetric, early, and moderate/advanced glaucoma (P < 0.05). Decreased RA was correlated with worse VFI in preperimetric and early glaucoma only (P ≤ 0.04).
  
  
  CONCLUSIONS
  A decrease in rim area was significantly correlated with the fast VF component regardless of the baseline severity of glaucoma. Mean deviation and VFI correlated with change of rim area only in certain stages of glaucoma. The identification of the fast component seems a more robust and useful measure of glaucomatous change than MD or VFI.
authors.affiliation: The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States 2Department of Ophthalmology, Pusan National University School of Medicine, Busan, South Korea.
authors.forename: Ji-Woong
authors.initials: JW
authors.lastname: Lee
authors.affiliation: The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States.
authors.forename: Eun-Ah
authors.initials: EA
authors.lastname: Kim
authors.affiliation: The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States.
authors.forename: Francisco
authors.initials: F
authors.lastname: Otarola
authors.affiliation: The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States.
authors.forename: Esteban
authors.initials: E
authors.lastname: Morales
authors.affiliation: The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States 3Department of Biostatistics, Jonathan and Karin Fielding School of Public Health at UCLA, Los Angeles, C.
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.affiliation: Department of Biostatistics, Jonathan and Karin Fielding School of Public Health at UCLA, Los Angeles, California, United States.
authors.forename: Abdelmonem A
authors.initials: AA
authors.lastname: Afifi
authors.affiliation: The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States.
authors.forename: Kouros
authors.initials: K
authors.lastname: Nouri-Mahdavi
authors.affiliation: The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States.
authors.forename: Joseph
authors.initials: J
authors.lastname: Caprioli
mesh_terms: D000368:Aged; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology* / Q000503:physiopathology; D012189:Retrospective Studies; D012607:Scotoma / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*