title: Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins.
abstract: G-Protein-coupled receptors (GPCRs) were classically described as monomers. We now appreciate that they also function as homo- and hetero-oligomers, for which structural information is lacking. Here, we use available 3D structures and biochemical considerations to present and evaluate experimentally testable structural models for GPCR oligomers and associated G proteins.
authors.affiliation: Laboratory of Computational Medicine, Biostatistics Unit, Universitat Autónoma de Barcelona, 08193 Barcelona, Spain.
authors.forename: Arnau
authors.initials: A
authors.lastname: Cordomí
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red: Enfermedades neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5 28031, Madrid, Spain. Electronic address: dimartts@hotmail.com.
authors.forename: Gemma
authors.initials: G
authors.lastname: Navarro
authors.affiliation: Cell and Molecular Neuropharmacology Laboratory, Neurosciences Division, CIMA (Centro de Investigación Médica Aplicada), Universidad de Navarra, 31008 Pamplona, Spain; Department of Biochemistry and Genetics, School of Science, University of Navarra, Pamplona 31008, Spain.
authors.forename: María S
authors.initials: MS
authors.lastname: Aymerich
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red: Enfermedades neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5 28031, Madrid, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Franco
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D043562:Receptors, G-Protein-Coupled; D019204:GTP-Binding Proteins
keywords: GPCR; dimers; heteromer; model; oligomer; structure