title: [DYNAMICS OF THE CIRCADIAN BLOOD PRESSURE PROFILE DURING COMBINED AMLODIPINE-VALSARTAN THERAPY IN FAR NORTH RESIDENTS].
abstract: The aim of the work was to study dynamics of daily arterial pressure profile during combined antihypertensive therapy starting from calcium and angiotensin II antagonists (amlodipine-valsartan) in Far North employees suffering arterial hypertension engaged on different working schedules. A total of 137 patients with grade I-III AH were divided into 2 groups. Those in group 1 worked day shifts (n=70) and the remaining ones worked night shifts (group 2). 129 patients completed the course of therapy. The final mean daily doses of amlodipine-valsartan were 8.2 ± 1.1/144.8 1.8 and 9.4 ± 1.6/197.8 ± 3.5 mg in groups I and 2 respectively. AP monitoring was performed before, 4 weeks and 6 months after therapy. Six months after the onset of amlodipine-valsartan therapy 97.2 and 97.6% of the patients in groups 1 and 2 respectively showed the target AP level and normalization of daily AP profile. Daily variability of AP in group 2 (excepting night-time variability) was also normal. Morning AP dynamics markedly improved in both groups. Most patients demonstrated excellent compliance with therapy due to its high efficacy and good tolerability.
authors.forename: I L
authors.initials: IL
authors.lastname: Zapesochnaya
authors.forename: A G
authors.initials: AG
authors.lastname: Avtandilov
mesh_terms: D000328:Adult; D017311:Amlodipine / Q000008:administration & dosage / Q000494:pharmacology*; D000068838:Amlodipine, Valsartan Drug Combination; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001110:Arctic Regions; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm / Q000502:physiology*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013777:Tetrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D014940:Work Schedule Tolerance / Q000502:physiology
chemical_list: D000068838:Amlodipine, Valsartan Drug Combination; D000959:Antihypertensive Agents; D004338:Drug Combinations; D013777:Tetrazoles; D017311:Amlodipine