title: Selenium-Substituted Hydroxyapatite/Biodegradable Polymer/Pamidronate Combined Scaffold for the Therapy of Bone Tumour.
abstract: The present study evaluated a new concept of combined scaffolds as a promising bone replacement material for patients with a bone tumour or bone metastasis. The scaffolds were composed of hydroxyapatite doped with selenium ions and a biodegradable polymer (linear or branched), and contained an active substance-bisphosphonate. For this purpose, a series of biodegradable polyesters were synthesized through a ring-opening polymerization of ε-caprolactone or d,l-lactide in the presence of 2-hydroxyethyl methacrylate (HEMA) or hyperbranched 2,2-bis(hydroxymethyl)propionic acid polyester-16-hydroxyl (bis-MPA) initiators, substances often used in the synthesis of medical materials. The polymers were obtained with a high yield and a number-average molecular weight up to 45,300 (g/mol). The combined scaffolds were then manufactured by a direct compression of pre-synthesized hydroxyapatite doped with selenite or selenate ions, obtained polymer and pamidronate as a model drug. It was found that the kinetic release of the drug from the scaffolds tested in vitro under physiological conditions is strongly dependent on the physicochemical properties and average molecular weight of the polymers. Furthermore, there was good correlation with the hydrolytic biodegradation results of the scaffolds fabricated without drug. The preliminary findings suggest that the fabricated combined scaffolds could be effectively used for the sustained delivery of bioactive molecules at bone defect sites.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland. eoledzka@wum.edu.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Oledzka
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland. marcin.sobczak@wp.pl.
authors.forename: Marcin
authors.initials: M
authors.lastname: Sobczak
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland. joanna.kolmas@wum.edu.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kolmas
authors.affiliation: Department of Environmental Health Science, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Banacha 1,Warsaw 02-097, Poland. gnalecz@wum.edu.pl.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Nalecz-Jawecki
mesh_terms: D063566:Biodegradable Plastics / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D050071:Bone Density Conservation Agents / Q000737:chemistry*; D004164:Diphosphonates / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D000077268:Pamidronate; D011091:Polyesters / Q000737:chemistry; D012643:Selenium / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014733:Vibrio / Q000187:drug effects
chemical_list: D063566:Biodegradable Plastics; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D008689:Methacrylates; D011091:Polyesters; C005044:hydroxyethyl methacrylate; D017886:Durapatite; D012643:Selenium; D000077268:Pamidronate
keywords: biocomposite; biodegradable polymers; bisphosphonates; bone tumour; drug delivery systems; hydroxyapatite