title: Effectiveness of a novel topical powder on the treatment of traumatic oral ulcers in orthodontic patients: A randomized controlled trial.
abstract: OBJECTIVE
  To determine if 2-DeNT Oral Topical Powder is an effective treatment for traumatic oral ulcers.
  
  
  METHODS
  Of the 46 patients who were randomly allocated, 20 patients from the experimental group and 17 from the placebo control group completed the study. The patients, operators, and evaluators were all blinded. Patients applied the powder twice a day and completed a diary twice a day for 10 days. The diary was used to monitor the size of the lesions and pain levels (using a 10-cm visual analog scale).
  
  
  RESULTS
  By day 5, the ulcers in the experimental group had reduced in size by approximately 70%; and ulcers in the control group had reduced in size by 56%. The experimental-group ulcers were significantly (P < .05) smaller than the control-group ulcers from day 5 through day 9. Ulcers in the experimental group were completely resolved by day 8, whereas control-group ulcers were still present on day 10. Patients experienced a significant amount of stimulated pain until the night of day 2 in the experimental group and until the night of day 5 in the control group, but group differences in pain were not statistically significant.
  
  
  CONCLUSIONS
  The 2DeNT Oral Topical powder was more effective than the placebo powder at accelerating the healing of oral traumatic ulcers.
authors.affiliation: a  Private practice, Charlotte, NC.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Rennick
authors.affiliation: b  Associate Professor and Chairman, Orthodontic Department, Texas A&M University Baylor College of Dentistry, Dallas, Tex.
authors.forename: Phillip M
authors.initials: PM
authors.lastname: Campbell
authors.affiliation: c  Assistant Professor, Oral Pathology, Texas A&M University Baylor College of Dentistry, Dallas, Tex.
authors.forename: Aparna
authors.initials: A
authors.lastname: Naidu
authors.affiliation: d  Associate Professor, Orthodontic Department, Texas A&M University Baylor College of Dentistry, Dallas, Tex.
authors.forename: Reginald W
authors.initials: RW
authors.lastname: Taylor
authors.affiliation: e  Regents Professor and Director of Orthodontic Research, Orthodontic Department, Texas A&M University Baylor College of Dentistry, Dallas, Tex.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Buschang
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D019226:Oral Ulcer / Q000188:drug therapy*; D010146:Pain; D010147:Pain Measurement; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
keywords: Duration; Pain; Traumatic oral ulcers; Treatment; Ulcer size