title: IgG4-related plasma cell granuloma of the maxillary sinus: A report of 2 cases.
abstract: We report 2 rare cases of IgG4-related plasma cell granuloma of the maxillary sinus. Histologically, both lesions were characterized by severe lymphoplasmacytic infiltration. In 1 case, fibrous sclerosis and obliterative arteritis were observed. Immunohistochemical study demonstrated that IgG4-positive cells comprised more than 40% of the IgG-positive plasma cells. Moreover, the serum IgG4 level was elevated in both cases. A good responsiveness to steroid therapy has been seen in IgG4-related disease. From a therapeutic perspective, it is important to recognize IgG4-related plasma cell granuloma.
authors.affiliation: Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine, Mibu, Tochigi, 321-0293 Japan. k-masaru@dokkyomed.ac.jp.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Nakazato
authors.forename: Kaoru
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Masawa
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D006104:Granuloma, Plasma Cell / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000097:blood; D007150:Immunohistochemistry; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged
chemical_list: D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G