title: Prognostic significance of Ubiquilin1 expression in invasive breast cancer.
abstract: OBJECTIVE
  To explore the correlation between Ubiquilin1 (UBQLN1) expression and clinicopathological characteristics and determine its prognostic significance in patients with breast cancer.
  
  
  METHODS
  UBQLN1 expression was evaluated by immunohistochemistry in 125 invasive breast cancer samples. The association between UBQLN1 and clinicopathological parameters and prognosis of breast cancer were detected.
  
  
  RESULTS
  The UBQLN1 protein was overexpressed in breast cancer samples (68/125) and associated with tumor size (P = 0.034), lymph node metastasis (P = 0.035), TNM stage (P = 0.049) and vascular invasion (P = 0.003). The DFS and OS rates at 5 years were 27.7% and 48.7% for UBQLN1 positive patients compared with 49.6% and 77.4% for UBQLN1 negative patients, respectively (both P = 0.001). Multivariate analyses revealed that UBQLN1 was an independent prognostic factor for overall survival (hazard ratio, 2.416; 95% CI, 1.134-5.149, P= 0.022) and disease-free survival (hazard ratio, 2.113; 95% CI, 1.203-3.709, P= 0.009). Furthermore, UBQLN1 overexpression was associated with poor prognosis in patients without lymph node metastasis (DFS 35 months vs 62 months, P = 0.005; OS 68 months vs 72 months, P = 0.017).
  
  
  CONCLUSIONS
  The expression level of UBQLN1 and prognosis in breast cancer is clarified for the first time and UBQLN1 seems to be a novel molecular marker to predict poor prognosis in breast cancer.
authors.affiliation: Department of Breast Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Yunchao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Breast Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.|Division of Hematology and Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Janice
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Breast Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Breast Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Breast Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Lv
authors.affiliation: Department of Breast Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Mu
authors.affiliation: Department of Breast Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Breast Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Fu
authors.affiliation: Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Breast Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Li
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000071183:Autophagy-Related Proteins; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002352:Carrier Proteins / Q000096:biosynthesis*; D018797:Cell Cycle Proteins / Q000096:biosynthesis*; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000071183:Autophagy-Related Proteins; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; C107792:UBQLN1 protein, human
keywords: Breast cancer; UBQLN1; prognosis