title: [Expressions of CD133, E-cadherin, and Snail in epithelial ovarian cancer and their clinicopathologic and prognostic implications].
abstract: OBJECTIVE
  To explore expressions of CD133, E-cadherin and Snail in human epithelial ovarian cancer (EOC) and elucidate their relationship with the clinicopathologic features and prognosis of the patients.
  
  
  METHODS
  The expression of CD133, E-cadherin and Snail were detected by immunohistochemical staining in 150 specimens of EOC and 50 specimens of benign ovarian epithelial tumor tissues.
  
  
  RESULTS
  The positivity rates of CD133, E-cadherin and Snail protein in EOC were 58.7%, 60.7% and 32.7%, respectively, significantly different from the rates in benign epithelial tumor tissues (10%, 8.0%, and 70%, respectively; P<0.05). The expressions of CD133, E-cadherin and Snail in EOC were significantly correlated with abdominal organ and lymphnode metastases and FIGO stage (P<0.01). E-cadherin expression was inversely correlated with Snail and CD133 expression (r=-0.545 and -0.570, P<0.01), and the latter two were positively correlated (r=0.599, P<0.01). Overexpressions of CD133 and Snail and a decreased expression of E-cadherin were all related to a poor prognosis of the patients (P<0.05). FIGO stage and expressions of CD133, E-cadherin and Snail were all independent prognostic factors of EOC (P<0.05).
  
  
  CONCLUSIONS
  The expressions of CD133, E-cadherin and Snail are related to lymph node metastasis, clinical stage, and prognosis of EOC. Combined detection of these indexes provides important evidence for predicting the progression and prognosis of EOC.
authors.affiliation: Department of Pathology, First Affiliated Hospital of Bengbu Medical College/Anhui Key Laboratory of Infection and Immunology, Bengbu 233030, China.E-mail: yulan790210@163.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Shiwu
authors.initials: S
authors.lastname: Wu
authors.forename: Wenqing
authors.initials: W
authors.lastname: Song
authors.forename: Zenong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Bingqin
authors.initials: B
authors.lastname: Guo
mesh_terms: D000071916:AC133 Antigen; D015703:Antigens, CD / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D000077216:Carcinoma, Ovarian Epithelial; D018450:Disease Progression; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D010455:Peptides / Q000378:metabolism*; D011379:Prognosis; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors