title: Hepatic and branchial xenobiotic biomarker responses in Solea spp. from several NW Mediterranean fishing grounds.
abstract: The common sole, Solea solea and the Senegalese sole, Solea senegalensis are two important commercial benthic species that coexist in the NW Mediterranean Sea. Several common biomarkers of chemical exposure were measured in two organs (liver and gills) involved in a different degree in biotransformation and detoxification processes. These parameters were: phase I cytochrome P450 CYP1A-dependent ethoxyresorufin O-deethylase and carboxylesterase activities, phase II glutathione S-transferase activity and the enzymatic antioxidants: catalase, glutathione reductase and glutathione peroxidase. Principal Component Analysis (PCA) considering biometric variables (size and weight) and all liver and gill biomarkers discriminated at a certain extent individuals of both species collected at the different fishing grounds. Esterase inhibition by the organophosphorus pesticides dichlorvos and diazinon was also compared in vitro in muscle, liver and gill of the two species revealing a differential sensitivity. The use of benthic sole in pollution monitoring of Southern Europe is discussed as local sentinel in respect to other benthic fish from more Northern latitudes.
authors.affiliation: Departamento Biología Funcional y Antropología Física, Universitat de València, Dr. Moliner 50 Burjassot, 46100 Valencia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Siscar
authors.affiliation: Instituto de Acuicultura Torre de la Sal (IATS-CSIC), 12595 Ribera de Cabanes, Castellón, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Varó
authors.affiliation: Institut de Ciencies del Mar (ICM-CSIC), Passeig Marítim de la Barceloneta 37-49 08003, Barcelona, Spain. Electronic address: msole@icm.csic.es.
authors.forename: M
authors.initials: M
authors.lastname: Solé
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D003976:Diazinon / Q000378:metabolism*; D004006:Dichlorvos / Q000378:metabolism*; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D005412:Flatfishes / Q000378:metabolism*; D005880:Gills / Q000201:enzymology; D007306:Insecticides / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D008522:Mediterranean Sea; D009132:Muscles / Q000201:enzymology; D013030:Spain; D013045:Species Specificity; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism*; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D007306:Insecticides; D014874:Water Pollutants, Chemical; D015262:Xenobiotics; D004006:Dichlorvos; D003976:Diazinon
keywords: Antioxidant enzymes; CbE; Diazinon; Dichlorvos; EROD; GST