title: Effect observation of anti epileptic drugs on serum folic acid and vitamin B12 of epileptic patients.
abstract: OBJECTIVE
  Comparative analysis of the effect of antiepileptic drugs on the epileptic (tonic clonic seizure type) patient's serum folate and vitamin B12 concentrations.
  
  
  METHODS
  Consecutively, 84 cases from September 2010 to September 2014 from the Department of Internal Medicine of our hospital were considered to diagnose as epilepsy nerve. Among which, 49 cases received anti epileptic drug treatment (treatment group), 35 cases received treatment without anti epileptic drugs (non-treatment group); At the same period, 42 nonepileptic patients (control group) underwent the analysis of the difference of serum folate and vitamin B12 concentrations of among the three groups of patients before the test, and at the end of test with the contrast analysis of difference of clinical efficiency and thrombosis rate.
  
  
  RESULTS
  Serum folic acid level of patients in the treatment group decreased significantly after test, vitamin B12 level was significantly higher, the differences were statistically significant (P<0.05), but folic acid and vitamin B12 concentration of non-treatment group and the control group did not change, and the differences were not statistically significant (P>0.05). Clinical efficiency of treatment group patients was significantly higher than that of the non-treatment group; the incidence of thrombosis was significantly lower than that of the non-treatment group, and the difference was statistically significant (P<0.05).
  
  
  CONCLUSIONS
  Antiepileptic drugs can significantly improve clinical efficacy of the epilepsy tonic clonic seizure type patients, which may be related to the decrease of serum levels of folate and vitamin B12-increased concentration.
authors.affiliation: Neurology Department 2, Xuzhou First People's Hospital, Xuzhou, Jiangsu, China - wangnuan81@sohu.com.
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: N
authors.initials: N
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.forename: C
authors.initials: C
authors.lastname: Yu
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016903:Drug Monitoring / Q000379:methods; D004827:Epilepsy / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000097:blood*; D014803:Vitamin B Complex / Q000097:blood*
chemical_list: D000927:Anticonvulsants; D015415:Biomarkers; D014803:Vitamin B Complex; D010672:Phenytoin; D005492:Folic Acid; D014805:Vitamin B 12