title: The effect of two different high-flux dialysis membranes on insulin resistance in non-diabetic end-stage renal disease patients.
abstract: OBJECTIVE
  The aim of this study was to investigate the effect of two different types of high-flux dialysis membranes on insulin resistance among patients who are receiving hemodialysis (HD) due to end-stage renal failure (ESRF).
  
  
  METHODS
  Forty-six (21 female, 25 male) patients were included in the study, who were on HD treatment due to stage-5 chronic renal failure. Prior to the study, fasting insulin resistance via Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) and fractioned urea clearance (Kt/V) values were calculated using the urokinetic model. The polysulfone (PS) dialysis membrane of all patients included in the study was replaced with "polyarylethersulfone, polyvinylpyrrolidone, polyamide (PPP)" high-flux membrane that has the same surface area over 12 weeks. At the end of the 12-week period, HOMA and Kt/V values were recalculated.
  
  
  RESULTS
  At the end of the 12-week period, Kt/V values rose statistically significant from 1.575 to 1.752 (p = 0.002). HOMA-IR values declined, though not statistically significant, from 3.268 to 2.926 (p = 0.085). PPP high-flux membrane increased the Kt/V values significantly compared to the PS membrane, while it decreased the insulin resistance and increased insulin sensitivity.
  
  
  CONCLUSIONS
  The two different types of high-flux dialysis membranes used for HD have different effects on insulin sensitivity. Compared to the PS membrane, PPP high-flux membrane decreased insulin resistance by increasing insulin sensitivity among non-diabetic ESRF patients.
authors.affiliation: a Department of Endocrinology .
authors.forename: Mujdat
authors.initials: M
authors.lastname: Kara
authors.affiliation: b Department of General Surgery , and.
authors.forename: Ercument
authors.initials: E
authors.lastname: Gurluler
authors.affiliation: c Department of Nephrology , Acıbadem International Hospital , Istanbul , Turkey.
authors.forename: Ulkem
authors.initials: U
authors.lastname: Cakır
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009757:Nylons; D010592:Pharmaceutic Aids; D011108:Polymers; D011205:Povidone; D006435:Renal Dialysis / Q000145:classification*; D013450:Sulfones
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008567:Membranes, Artificial; D009757:Nylons; D010592:Pharmaceutic Aids; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D011205:Povidone
keywords: Dialysis membranes; end-stage renal disease; high-flux; insulin resistance