title: [Link between non hypoxemic chronic obstructive pulmonary disease and executive functioning in oldest old].
abstract: COPD (chronic obstructive pulmonary disease) may result in cognitive disorders (mainly executive) even without hypoxemia. The aim of this descriptive study was to highlight a deficit in task-switching in non-hypoxemic patient with COPD and mild cognitive impairment (MCI) or Alzheimer disease (AD). The main judgment criterion was patients' performances on the TMTA and B. COPD patients were recruited via the database (CogDisCo) of the geriatric medicine department at Pitié Salpêtrière hospital in Paris. 7 patients had Alzheimer's disease (AD), and 11 mild cognitive impairment (MCI): they were matched for age, sex, MMSE, education level with controls subjects without COPD. There was no significant difference between the two groups. However, patients with COPD and MCI required, on average, an extra 13 seconds compared with patient without COPD for the TMTA and 18 seconds for the TMTB. Patients with COPD and AD needed, on average, an extra 63 seconds for TMTA and 97 seconds for TMTB. The number of errors for the TMTB was the same in the both groups. This preliminary study does not show statistically significant results but the time for achieving TMT was longer in the population with COPD whether AD or MCI. These results encourage us to continue with prospective studies on larger samples.
authors.affiliation: Centre de gériatrie, Groupe hospitalier Pitié Salpêtrière - Charles Foix, APHP, DHU FAST, Paris, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Mora
authors.affiliation: Centre de gériatrie, Groupe hospitalier Pitié Salpêtrière - Charles Foix, APHP, DHU FAST, Paris, France, Sorbonne Universités, UPMC Université Paris 6, UMR 8256 B2A, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Sagot
authors.affiliation: Centre de gériatrie, Groupe hospitalier Pitié Salpêtrière - Charles Foix, APHP, DHU FAST, Paris, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Dieudonné
authors.affiliation: Centre de gériatrie, Groupe hospitalier Pitié Salpêtrière - Charles Foix, APHP, DHU FAST, Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Faucounau
authors.affiliation: Centre de gériatrie, Groupe hospitalier Pitié Salpêtrière - Charles Foix, APHP, DHU FAST, Paris, France.
authors.forename: Zina
authors.initials: Z
authors.lastname: Barrou
authors.affiliation: Centre de gériatrie, Groupe hospitalier Pitié Salpêtrière - Charles Foix, APHP, DHU FAST, Paris, France, Sorbonne Universités, UPMC Université Paris 6, UMR 8256 B2A, Paris, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Breining
authors.affiliation: Centre de gériatrie, Groupe hospitalier Pitié Salpêtrière - Charles Foix, APHP, DHU FAST, Paris, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Greffard
authors.affiliation: Centre de gériatrie, Groupe hospitalier Pitié Salpêtrière - Charles Foix, APHP, DHU FAST, Paris, France.
authors.forename: Judith
authors.initials: J
authors.lastname: Cohen-Bittan
authors.affiliation: Centre de gériatrie, Groupe hospitalier Pitié Salpêtrière - Charles Foix, APHP, DHU FAST, Paris, France, Sorbonne Universités, UPMC Université Paris 6, UMR 8256 B2A, Paris, France, CNRS, UMR 8256 B2A, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Verny
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology; D003072:Cognition Disorders / Q000523:psychology; D004522:Educational Status; D056344:Executive Function; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000523:psychology*; D007600:Judgment; D008297:Male; D009483:Neuropsychological Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000523:psychology*; D014145:Trail Making Test
keywords: cognitive impairment; elderly; executive function; non hypoxemic COPD; trail making test