title: Brønsted acid-catalyzed Mannich reaction through dual activation of aldehydes and N-Boc-imines.
abstract: In the presence of a Brønsted acid catalyst, both aldehydes and N-Boc-aminals were converted to enecarbamates and N-Boc-iminium salts as activated nucleophiles and electrophiles, respectively, giving unprecedented Mannich adducts. The asymmetric variant of the present Mannich reaction has also been demonstrated with a chiral phosphoric acid catalyst.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. maruoka@kuchem.kyoto-u.ac.jp.
authors.forename: Taichi
authors.initials: T
authors.lastname: Kano
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. maruoka@kuchem.kyoto-u.ac.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Aota
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. maruoka@kuchem.kyoto-u.ac.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Asakawa
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. maruoka@kuchem.kyoto-u.ac.jp.
authors.forename: Keiji
authors.initials: K
authors.lastname: Maruoka