title: Silver diamine fluoride and glass ionomer differentially remineralize early caries lesions, in situ.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the percent mean mineral density (MD) change of early caries lesions after the application of silver diamine fluoride (SDF) or glass ionomer cement (GIC).
  
  
  METHODS
  This double-blind, crossover study involved two experimental phases of 28 days each. Thirty-two pairs of enamel slabs were created from the proximal surfaces of 16 premolars. Each pair of artificial carious slabs was randomly divided into the control or test group (38 % SDF or GIC). The slabs were attached to orthodontic brackets and bonded to the maxillary first permanent molars of 16 subjects for 28 days. After a 7-day washout period between phases, the subjects received the other material for the second phase. The mean MD of the lesions was measured by microcomputed tomography.
  
  
  RESULTS
  SDF yielded a percent mean MD increase at a depth of 0-84 μm, although increase in the GIC group was observed at a depth of 24-108 μm. The percent mean MD changes of the SDF and GIC groups were similar (p = 0.100) and significantly higher than in control (p < 0.001, p = 0.003, respectively).
  
  
  CONCLUSIONS
  The two materials increased the percent mean MD change of early proximal caries lesions to a similar extent, but with different spatial patterns.
  
  
  CONCLUSIONS
  Due to deeper level of GIC remineralization, the refractive index of the GIC applied enamel might be closer to sound enamel. Hence, GIC is recommended for remineralization of anterior teeth. SDF staining makes it unsuitable for use in anterior teeth; thus, it is reserved for use in posterior teeth.
authors.affiliation: Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, 34 Henry Dunant Road, Pathumwan, Bangkok, 10330, Thailand.
authors.forename: Ratichanok
authors.initials: R
authors.lastname: Nantanee
authors.affiliation: Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, 34 Henry Dunant Road, Pathumwan, Bangkok, 10330, Thailand.
authors.forename: Busayarat
authors.initials: B
authors.lastname: Santiwong
authors.affiliation: Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, 34 Henry Dunant Road, Pathumwan, Bangkok, 10330, Thailand. ctrairat@gmail.com.
authors.forename: Chutima
authors.initials: C
authors.lastname: Trairatvorakul
authors.affiliation: Department of Cariology and Operative Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Hamba
authors.affiliation: Department of Cariology and Operative Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Tagami
mesh_terms: D001641:Bicuspid; D002327:Cariostatic Agents / Q000494:pharmacology*; D018592:Cross-Over Studies; D003731:Dental Caries / Q000473:pathology; D003743:Dental Enamel / Q000000981:diagnostic imaging / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005460:Fluorides, Topical; D005899:Glass Ionomer Cements / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008963:Molar; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D018030:Silver Compounds; D013785:Thailand; D014089:Tooth Remineralization / Q000379:methods*; D055114:X-Ray Microtomography; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D005899:Glass Ionomer Cements; D000644:Quaternary Ammonium Compounds; D018030:Silver Compounds; C024633:silver diamine fluoride
keywords: Caries lesions; Glass ionomer cement; Mineral density; Silver diamine fluoride