title: Structure and antibacterial property of a new diterpenoid from Euphorbia helioscopia.
abstract: The present study was designed to isolate and evaluate the antibacterial activity of the compounds from the whole plant of Euphorbia helioscopia L.. Various chromatographic techniques were used to isolate and purify the compound. The structure of the compound was elucidated on basis of spectral data ((1)H NMR, (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC, NOESY, IR, and HR-ESI-MS). A new jatrophone-type diterpenoid (14α,15β-diacetoxy-3β-benzoyloxy-7β-nicotinoyloxy-9-oxo-jatropha-5E,11E-diene), named euphoheliosnoid E (1), was isolated from the whole plant of E. helioscopia L. Compound 1 showed significant anti-microbial activity against oral pathogens.
authors.affiliation: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China. Electronic address: gengyiliang_hqu@163.com.
authors.forename: Di
authors.initials: D
authors.lastname: Geng
authors.affiliation: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Yi
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Zhi-Da
authors.initials: ZD
authors.lastname: Min
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D015394:Molecular Structure; D009059:Mouth Diseases / Q000382:microbiology; D009525:Niacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D004224:Diterpenes; D010936:Plant Extracts; C000608796:euphoheliosnoid E; D009525:Niacin; C006386:jatrophone
keywords: Anti-microbial activity; Euphoheliosnoid E; Euphorbia helioscopia; Jatrophone-type diterpenoid