title: [MALE PRECONCEPTION CARE].
abstract: Planning pregnancy is very important to ensure the most comfortable and optimal conditions for conception, gestation and the subsequent birth of a healthy child. This review examines the effects and mechanisms of the damaging effect of external factors, social habits and certain diseases on the ejaculate quality, as well as ways to overcome them aiming to optimum preparation of a man to conceive. Several studies have shown an inverse relationship between semen quality and common diseases. Unfavorable environmental conditions, varicocele, endocrine causes, such as diabetes, obesity, and metabolic syndrome, are thought to be among the factors that could adversely affect the quality of sperm. Oxidative stress in the testicular microenvironment may lead to suppression of spermatogenesis and sperm DNA damage resulting in a decrease of their mobility and causing morphological abnormalities.
authors.forename: E A
authors.initials: EA
authors.lastname: Efremov
authors.forename: E V
authors.initials: EV
authors.lastname: Kasatonova
authors.forename: Ja I
authors.initials: JI
authors.lastname: Mel'nik
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004249:DNA Damage; D004785:Environmental Pollutants / Q000633:toxicity; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D016742:Preconception Care / Q000379:methods*; D012307:Risk Factors; D013094:Spermatozoa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D000975:Antioxidants; D004785:Environmental Pollutants