title: Hypometabolism in Posterior and Temporal Areas of the Brain is Associated with Cognitive Decline in Parkinson's Disease.
abstract: BACKGROUND
  Brain metabolic profiles of patients with Parkinson's disease (PD) and cognitive impairment or dementia are now available. It would be useful if data on brain metabolism were also predictive of the risk of a pejorative cognitive evolution - especially in the multidisciplinary management of advanced PD patients.
  
  
  OBJECTIVE
  The primary objective was to determine whether a specific brain metabolic pattern is associated with cognitive decline in PD.
  
  
  METHODS
  Sixteen advanced PD patients were screened for the absence of cognitive impairment (according to the Mattis dementia rating scale, MDRS) and underwent [18F]-fluorodeoxyglucose positron emission tomography brain imaging in the "off drug" state. The MDRS was scored again about two years later, categorizing patients as having significant cognitive decline (decliners) or not (stables). The two groups were then compared in terms of their brain metabolism at inclusion.
  
  
  RESULTS
  There were six decliners and ten stables. Significant hypometabolism in the two precunei (Brodmann area (BA) 31), the left middle temporal gyrus (BA21) and the left fusiform gyrus (BA37) was found in the decliner group compared withthe stables.
  
  
  CONCLUSIONS
  In advanced PD, a particular metabolic pattern may be associated with the onset of significant cognitive decline.
authors.affiliation: Université de Lille, Lille, France.|INSERM U1171, Lille, France.|Service de neurophysiologie clinique, CHRU Lille, Lille, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Tard
authors.affiliation: Service de médecine nucléaire, CHRU Lille, Lille, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Demailly
authors.affiliation: Université de Lille, Lille, France.|INSERM U1171, Lille, France.|Service de neurophysiologie clinique, CHRU Lille, Lille, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Delval
authors.affiliation: Université de Lille, Lille, France.|INSERM U1171, Lille, France.|Service de médecine nucléaire, CHRU Lille, Lille, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Semah
authors.affiliation: Université de Lille, Lille, France.|INSERM U1171, Lille, France.|Service de neurologie et pathologie du mouvement, CHRU Lille, Lille, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Defebvre
authors.affiliation: Université de Lille, Lille, France.|INSERM U1171, Lille, France.|Service de neurologie et pathologie du mouvement, CHRU Lille, Lille, France.
authors.forename: Kathy
authors.initials: K
authors.lastname: Dujardin
authors.affiliation: Université de Lille, Lille, France.|INSERM U1171, Lille, France.|Service de neurologie et pathologie du mouvement, CHRU Lille, Lille, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Moreau
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003072:Cognition Disorders / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008609:Mental Status Schedule; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism
chemical_list: D019788:Fluorodeoxyglucose F18