title: Self-Healing Supramolecular Self-Assembled Hydrogels Based on Poly(L-glutamic acid).
abstract: Self-healing polymeric hydrogels have the capability to recover their structures and functionalities upon injury, which are extremely attractive in emerging biomedical applications. This research reports a new kind of self-healing polypeptide hydrogels based on self-assembly between cholesterol (Chol)-modified triblock poly(L-glutamic acid)-block-poly(ethylene glycol)-block-poly(L-glutamic acid) ((PLGA-b-PEG-b-PLGA)-g-Chol) and β-cyclodextrin (β-CD)-modified poly(L-glutamic acid) (PLGA-g-β-CD). The hydrogel formation relied on the host and guest linkage between β-CD and Chol. This study demonstrates the influences of polymer concentration and β-CD/Chol molar ratio on viscoelastic behavior of the hydrogels. The results showed that storage modulus was highest at polymer concentration of 15% w/v and β-CD/Chol molar ratio of 1:1. The effect of the PLGA molecular weight in (PLGA-b-PEG-b-PLGA)-g-Chol on viscoelastic behavior, mechanical properties and in vitro degradation of the supramolecular hydrogels was also studied. The hydrogels showed outstanding self-healing capability and good cytocompatibility. The multilayer structure was constructed using hydrogels with self-healing ability. The developed hydrogels provide a fascinating glimpse for the applications in tissue engineering.
authors.affiliation: School of Materials Science and Engineering, Shanghai University , Shanghai, 200444, P. R. China.
authors.forename: Guifei
authors.initials: G
authors.lastname: Li
authors.affiliation: School of Materials Science and Engineering, Shanghai University , Shanghai, 200444, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.affiliation: School of Materials Science and Engineering, Shanghai University , Shanghai, 200444, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, Shanghai University , Shanghai, 200444, P. R. China.
authors.forename: Shifeng
authors.initials: S
authors.lastname: Yan
authors.affiliation: School of Materials Science and Engineering, Shanghai University , Shanghai, 200444, P. R. China.
authors.forename: Kunxi
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun, 130022, P. R. China.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Ding
authors.affiliation: School of Materials Science and Engineering, Shanghai University , Shanghai, 200444, P. R. China.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Yin
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D018698:Glutamic Acid / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D011091:Polyesters; D047392:beta-Cyclodextrins; C000595637:poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide); D018698:Glutamic Acid; D011092:Polyethylene Glycols; C031215:betadex