title: Palladium-Catalyzed Carbonylative Cyclization of Arenes by C-H Bond Activation with DMF as the Carbonyl Source.
abstract: A novel palladium-catalyzed CO-gas- and autoclave-free protocol for the synthesis of 11H-pyrido[2,1-b]quinazolin-11-ones has been developed. Quinazolinones, which are omnipresent motif in many pharmaceuticals and agrochemicals, were prepared in good yields by C-H bond activation and annulation using DMF as the CO surrogate. A (13) CO-labelled DMF control experiment demonstrated that CO gas was released from the carbonyl of DMF with acid as the promotor. The kinetic isotope effect (KIE) value indicated that the C-H activation step may not be involved in the rate-determining step. This methodology is operationally simple and showed a broad substrate scope with good to excellent yields.
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
authors.forename: Jianbin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Str. 29a, 18059 Rostock (Germany).|Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou 310018 (P. R. China).
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Feng
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
authors.forename: Kishore
authors.initials: K
authors.lastname: Natte
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Str. 29a, 18059 Rostock (Germany). xiao-feng.wu@catalysis.de.|Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou 310018 (P. R. China). xiao-feng.wu@catalysis.de.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wu
keywords: CH activation; DMF; carbonylation; heterocycles; palladium