title: The cost-effectiveness of second-eye cataract surgery in the UK.
abstract: BACKGROUND
  Elective cataract surgery is the most commonly performed surgical procedure in developed countries. However, it is unclear whether cataract surgery on the second eye provides enough incremental benefit to be considered cost-effective. This study conducted a cost-effectiveness analysis of second-eye cataract surgery in the U.K.
  
  
  METHODS
  A cost-effectiveness analysis.
  
  
  METHODS
  A decision-analytical model was developed to estimate the cost-effectiveness of second-eye cataract surgery, based on a comprehensive epidemiological and economic review to develop the parameters for the model. The model followed the clinical pathway of cohorts of patients receiving second-eye cataract surgery and included costs and health benefits associated with post-surgical complications.
  
  
  RESULTS
  In the model, second-eye surgery generated 0.68 additional quality-adjusted life years (QALY) with an incremental cost-effectiveness ratio of £1,964 per QALY gained. In sensitivity analyses, model results were most sensitive to changes in the health-related quality of life (HRQoL) gain associated with second-eye surgery, but otherwise robust to changes in parameter values. The probability that second-eye surgery is cost-effective at willingness to pay thresholds of £10,000 and £20,000 was 100%.
  
  
  CONCLUSIONS
  Second-eye cataract surgery is generally cost-effective based on the best available data and under most assumptions. However, there are only a small number of clinical trials for second-eye cataract surgery, and these have not been conducted in recent years.
authors.affiliation: SHTAC, University of Southampton, Southampton, Hampshire SO16 7NS, UK.
authors.forename: Keith
authors.initials: K
authors.lastname: Cooper
authors.affiliation: SHTAC, University of Southampton, Southampton, Hampshire SO16 7NS, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Shepherd
authors.affiliation: SHTAC, University of Southampton, Southampton, Hampshire SO16 7NS, UK.
authors.forename: Geoff
authors.initials: G
authors.lastname: Frampton
authors.affiliation: SHTAC, University of Southampton, Southampton, Hampshire SO16 7NS, UK.
authors.forename: Petra
authors.initials: P
authors.lastname: Harris
authors.affiliation: Clinical and Experimental Sciences, University of Southampton, Southampton, Hampshire, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Lotery
mesh_terms: D000368:Aged; D002386:Cataract / Q000191:economics; D002387:Cataract Extraction / Q000009:adverse effects / Q000191:economics* / Q000706:statistics & numerical data; D003362:Cost-Benefit Analysis; D019091:Critical Pathways / Q000191:economics; D017048:Health Care Costs / Q000706:statistics & numerical data; D006801:Humans; D018803:Models, Economic; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012086:Reoperation / Q000191:economics; D006113:United Kingdom
keywords: cataract; cost-effectiveness; older people; second-eye surgery