title: NIR light propagation in a digital head model for traumatic brain injury (TBI).
abstract: Near infrared spectroscopy (NIRS) is capable of detecting and monitoring acute changes in cerebral blood volume and oxygenation associated with traumatic brain injury (TBI). Wavelength selection, source-detector separation, optode density, and detector sensitivity are key design parameters that determine the imaging depth, chromophore separability, and, ultimately, clinical usefulness of a NIRS instrument. We present simulation results of NIR light propagation in a digital head model as it relates to the ability to detect intracranial hematomas and monitor the peri-hematomal tissue viability. These results inform NIRS instrument design specific to TBI diagnosis and monitoring.
authors.affiliation: Raytheon, 1601 N Plano Rd, Richardson, TX 75081, USA ; Department of Electrical Engineering, University of Texas Dallas, 800 W Campbell Rd, Richardson, TX 75080, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Francis
authors.affiliation: Department of Electrical Engineering, University of Texas Dallas, 800 W Campbell Rd, Richardson, TX 75080, USA ; Department of Bioengineering, University of Texas Arlington, 500 UTA Boulevard, Arlington, TX 76010, USA.
authors.forename: Bilal
authors.initials: B
authors.lastname: Khan
authors.affiliation: Department of Bioengineering, University of Texas Arlington, 500 UTA Boulevard, Arlington, TX 76010, USA.
authors.forename: George
authors.initials: G
authors.lastname: Alexandrakis
authors.affiliation: Department of Electrical Engineering, University of Texas Dallas, 800 W Campbell Rd, Richardson, TX 75080, USA.
authors.forename: James
authors.initials: J
authors.lastname: Florence
authors.affiliation: Department of Electrical Engineering, University of Texas Dallas, 800 W Campbell Rd, Richardson, TX 75080, USA.
authors.forename: Duncan
authors.initials: D
authors.lastname: MacFarlane
keywords: (110.0113) Imaging through turbid media; (170.0110) Imaging systems