title: To Stage Alzheimer's Disease Related Neurodegeneration Using one Section of Hippocampus.
abstract: For Braak staging of Alzheimer's disease (AD), the assessment of only hippocampal section has been proposed. In two published modifications, the emphasis is on the pathology in Ammon's horn. We investigated this approach in a cohort including 150 cases. A Braak stage was possible to assign in a subset of the cases, and the agreement rates varied from 60% to 36% . Thus, to reliably stage the AD-related neurodegeneration, regions such as the entorhinal, transentorhinal, temporo-occipital, and occipital cortices should be assessed as has also been recommended in 2012 by the National Institute on Aging - Alzheimer's Association guidelines.
authors.affiliation: Department of Clinical Pathology and Immunology, Uppsala University Hospital, Uppsala, Sweden.
authors.forename: Svetlana N
authors.initials: SN
authors.lastname: Popova
authors.affiliation: Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.|Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Samuli
authors.initials: S
authors.lastname: Pesälä
authors.affiliation: Department of Clinical Pathology and Immunology, Uppsala University Hospital, Uppsala, Sweden.|Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
authors.forename: Irina
authors.initials: I
authors.lastname: Alafuzoff
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008297:Male; D012720:Severity of Illness Index
keywords: Alzheimer’s disease; ammon’s horn; braak stage; hippocampus