title: Symptom reporting among prevalent tuberculosis cases who smoke, are HIV-positive or have hyperglycaemia.
abstract: Data from a tuberculosis (TB) prevalence survey conducted in 24 communities in Zambia and the Western Cape, South Africa, January-December 2010, were analysed to determine the influence of smoking, hyperglycaemia and human immunodeficiency virus (HIV) infection on TB symptom reporting in culture-confirmed TB cases. Of 123 790 adults eligible for enrolment, 90 601 (73%) consented and 64 463 had evaluable sputum samples. ORs and 95%CIs were calculated using a robust standard errors logistic regression model adjusting for clustering at community level. HIV-positive TB cases were more likely to report cough, weight loss, night sweats and chest pain than non-HIV-positive TB cases. TB cases who smoked or had hyperglycaemia did not report symptoms differently from cases without these comorbidities.
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
authors.forename: S
authors.initials: S
authors.lastname: Sattar
authors.affiliation: South African Centre for Epidemiological Modelling and Analysis, University of Stellenbosch, Cape Town, South Africa.
authors.forename: C
authors.initials: C
authors.lastname: Van Schalkwyk
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
authors.forename: M
authors.initials: M
authors.lastname: Claassens
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
authors.forename: R
authors.initials: R
authors.lastname: Dunbar
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Floyd
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
authors.forename: D A
authors.initials: DA
authors.lastname: Enarson
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Godfrey-Faussett
authors.affiliation: ZAMBART Project, University of Zambia Ridgeway Campus, Lusaka, Zambia.
authors.forename: H
authors.initials: H
authors.lastname: Ayles
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
authors.forename: N
authors.initials: N
authors.lastname: Beyers
keywords: case finding; comorbidities; screening