title: JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection.
abstract: The role of JAK/STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK/STAT signaling in somatic muscles of the Drosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes. Deletion of upd2 or upd3, but not the related os (upd1) gene, reduced the cellular immune response, and suppression of the JAK/STAT pathway in muscle cells reduced the encapsulation of wasp eggs and the number of circulating lamellocyte effector cells. These results suggest that JAK/STAT signaling in muscles participates in a systemic immune defense against wasp infection.
authors.affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden.
authors.forename: Hairu
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden.
authors.forename: Jesper
authors.initials: J
authors.lastname: Kronhamn
authors.affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden Institute of Biomedical Technology BMT Tampere University, Tampere, Finland.
authors.forename: Jens-Ola
authors.initials: JO
authors.lastname: Ekström
authors.affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden.
authors.forename: Gül Gizem
authors.initials: GG
authors.lastname: Korkut
authors.affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden Institute of Biomedical Technology BMT Tampere University, Tampere, Finland dan.hultmark@ucmp.umu.se.
authors.forename: Dan
authors.initials: D
authors.lastname: Hultmark
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000276:immunology* / Q000469:parasitology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D006434:Hemocytes / Q000276:immunology; D006790:Host-Parasite Interactions; D007111:Immunity, Cellular; D007113:Immunity, Innate; D053613:Janus Kinase 1 / Q000378:metabolism; D053612:Janus Kinases / Q000235:genetics / Q000378:metabolism*; D007814:Larva / Q000235:genetics / Q000276:immunology / Q000469:parasitology; D009132:Muscles / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D014157:Transcription Factors / Q000378:metabolism; D014863:Wasps
chemical_list: D016207:Cytokines; D029721:Drosophila Proteins; D050791:STAT Transcription Factors; D014157:Transcription Factors; C508880:Upd2 protein, Drosophila; C558732:Upd3 protein, Drosophila; D011505:Protein-Tyrosine Kinases; D053613:Janus Kinase 1; D053612:Janus Kinases
keywords: Drosophila; JAK/STAT signaling; innate immunity; muscles