title: Poisoning of cats and dogs by the carbamate pesticides aldicarb and carbofuran.
abstract: The intentional and accidental poisoning of animals and people is a threat to public health and safety worldwide. Necropsies and histopathological examinations of 26 cats and 10 dogs poisoned by the carbamates aldicarb and carbofuran, confirmed by thin layer chromatography (TLC) and high performance liquid chromatography with diode-array detector (HPLC-DAD) were analysed, with variable post mortem interval and conservation of the carcass. Biological matrices were collected for toxicological and histopathological analyses. High performance liquid chromatography with diode-array detector (HPLC-DAD) was utilized to detect aldicarb and its metabolites, aldicarb sulphoxide and aldicarb sulphone, and carbofuran. The variable post mortem interval and the method of conservation of the carcass may be harmful to toxicological, necroscopic and histopathological analyses, that should be performed in order to provide reliable evidences to investigate possible poisoning of animals, which is cruel crime, and are usually linked to domestic or social conflict.
authors.affiliation: Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: siqueira.adriana.vp@gmail.com.
authors.forename: Adriana
authors.initials: A
authors.lastname: de Siqueira
authors.affiliation: Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: Fernanda Auciello
authors.initials: FA
authors.lastname: Salvagni
authors.affiliation: Institute of Criminal Sciences, Sao Paulo State, Brazil.
authors.forename: Alberto Soiti
authors.initials: AS
authors.lastname: Yoshida
authors.affiliation: Laboratory of Toxicology, Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: Vagner
authors.initials: V
authors.lastname: Gonçalves-Junior
authors.affiliation: Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: Atilio Sersun
authors.initials: AS
authors.lastname: Calefi
authors.affiliation: Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil; Laboratory of Toxicology, Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: André Rinaldi
authors.initials: AR
authors.lastname: Fukushima
authors.affiliation: Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil; Laboratory of Toxicology, Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: Helenice de Souza
authors.initials: Hde S
authors.lastname: Spinosa
authors.affiliation: Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: Paulo César
authors.initials: PC
authors.lastname: Maiorka
mesh_terms: D000448:Aldicarb / Q000031:analogs & derivatives* / Q000506:poisoning; D000818:Animals; D002235:Carbofuran / Q000506:poisoning*; D002371:Cat Diseases / Q000139:chemically induced*; D002415:Cats; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D010575:Pesticides / Q000506:poisoning*
chemical_list: D010575:Pesticides; C030579:aldicarb sulfoxide; D000448:Aldicarb; C030580:aldicarb sulfone; D002235:Carbofuran
keywords: Aldicarb; Animal cruelty; Carbamate pesticides; Carbofuran; Cats/dogs; Forensic veterinary medicine