title: Review of topical beta blockers as treatment for infantile hemangiomas.
abstract: The treatment of infantile hemangiomas changed from the use of oral corticosteroids to oral propranolol on the serendipitous discovery of propanolol's clinical effectiveness in 2008. Since then, clinicians have begun to use topical beta blockers--in particular, timolol maleate 0.5% gel forming solution--with good effect. Topical beta blockers are now used for lesions with both deep and superficial components and those that are amblyogenic. When initiated in the proliferative phase of the lesion, the effectiveness of the treatment can be seen within days. There is no consensus on dosing, treatment bioavailability, or clinical assessment of lesions, but these are topics for future research.
authors.affiliation: Department of Pediatric Ophthalmology, Royal Berkshire Hospital, Reading and King Edward VII Hospital, Windsor, United Kingdom. Electronic address: sallylpainter@cantab.net.
authors.forename: Sally L
authors.initials: SL
authors.lastname: Painter
authors.affiliation: Department of Pediatric Ophthalmology, Royal Berkshire Hospital, Reading and King Edward VII Hospital, Windsor, United Kingdom.
authors.forename: Göran Darius
authors.initials: GD
authors.lastname: Hildebrand
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D018324:Hemangioma, Capillary / Q000188:drug therapy*; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000188:drug therapy*; D009883:Ophthalmic Solutions; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use; D019572:Retinal Neoplasms / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013999:Timolol / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions; D013999:Timolol; D011433:Propranolol
keywords: beta blocker; infantile hemangioma; timolol; topical