title: Hybrid minimally invasive esophagectomy for cancer: impact on postoperative inflammatory and nutritional status.
abstract: The purpose of this case-control study was to evaluate the impact of hybrid minimally invasive esophagectomy for cancer on surgical stress response and nutritional status. All 34 consecutive patients undergoing hybrid minimally invasive esophagectomy for cancer at our surgical unit between 2008 and 2013 were retrospectively compared with 34 patients undergoing esophagectomy with open gastric tubulization (open), matched for neoadjuvant therapy, pathological stage, gender and age. Demographic data, tumor features and postoperative course (including quality of life and systemic inflammatory and nutritional status) were compared. Postoperative course was similar in terms of complication rate. Length of stay in intensive care unit was shorter in patients undergoing hybrid minimally invasive esophagectomy (P = 0.002). In the first postoperative day, patients undergoing hybrid minimally invasive esophagectomy had lower C-reactive protein levels (P = 0.001) and white cell blood count (P = 0.05), and higher albumin serum level (P = 0.001). In this group, albumin remained higher also at third (P = 0.06) and seventh (P = 0.008) postoperative day, and C-reactive protein resulted lower at third post day (P = 0.04). Hybrid minimally invasive esophagectomy significantly improved the systemic inflammatory and catabolic response to surgical trauma, contributing to a shorter length of stay in intensive care unit.
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Scarpa
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cavallin
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: L M
authors.initials: LM
authors.lastname: Saadeh
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Pinto
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Alfieri
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cagol
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Da Roit
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Pizzolato
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Noaro
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pozza
authors.affiliation: Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Castoro
mesh_terms: D000368:Aged; D002097:C-Reactive Protein; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000097:blood / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods*; D005260:Female; D006801:Humans; D007902:Length of Stay; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D009752:Nutritional Status; D011184:Postoperative Period; D012189:Retrospective Studies; D012709:Serum Albumin; D016896:Treatment Outcome
chemical_list: D012709:Serum Albumin; D002097:C-Reactive Protein
keywords: esophageal cancer; esophagectomy; inflammation response; minimally invasive