title: A study of the efficacy of furosemide as a prophylaxis of acute renal failure in coronary artery bypass grafting patients: A clinical trial.
abstract: BACKGROUND
  Renal failure is a frequent event after coronary artery bypass grafting (CABG). Hemodynamic alterations during surgery as well as the underlying disease are the predisposing factors. We aimed to study intermittent furosemide therapy in the prevention of renal failure in patients undergoing CABG.
  
  
  METHODS
  In a single-blind randomized controlled trial, 123 elective CABG patients, 18-75 years, entered the study. Clearance of creatinine, urea and water were measured. Patients were randomly assigned into three groups: furosemide in prime (0.3-0.4 mg/kg); intermittent furosemide during CABG (0.2 mg/kg, if there was a decrease in urinary excretion) and control (no furosemide).
  
  
  RESULTS
  There was a significant change in serum urea, sodium and fluid balance in "intermittent furosemide" group; other variables did not change significantly before or after the operation. Post-operative fluid balance was significantly higher in "intermittent furosemide" group (2573 ± 205 ml) compared to control (1574.0 ± 155.0 ml) (P < 0.010); also, fluid balance was higher in "intermittent furosemide" group (2573 ± 205 ml) compared to "furosemide in prime" group (1935.0 ± 169.00 ml) (P < 0.010).
  
  
  CONCLUSIONS
  The study demonstrated no benefit from intermittent furosemide in elective CABG compared to furosemide in prime volume or even placebo.
authors.affiliation: Assistant Professor, Fellowship in Cardiac Anesthesiology, Alborz University of Medical Sciences, Karaj, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Bayat
authors.affiliation: Associate Professor, Fellowship in Cardiac Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Faritous
authors.affiliation: Associate Professor, Fellowship in Cardiac Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Aghdaei
authors.affiliation: Professor, Fellowship in Cardiac Anesthesiology, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Dabbagh
keywords: Coronary Artery Bypass Grafting; Furosemide; Renal Failure