title: Impact of PTEN IVS4 Polymorphism (rs3830675) on Cancer Susceptibility: An Updated Meta-analysis.
abstract: OBJECTIVE
  Phosphatase and tensin homolog (PTEN) acts as a tumor suppressor gene through the action of its phosphatase protein product. We performed a meta-analysis to evaluate their relationship.
  
  
  METHODS
  A comprehensive database search was performed. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association between PTEN IVS4 polymorphism and cancer.
  
  
  RESULTS
  The meta-analysis indicated that PTEN IVS4 (-/-) genotype was significantly associated with the risk of cancer (OR=1.47, 95% CI=1.11-1.84), especially for digestive cancer (OR=1.67, 95% CI=1.28-2.18) compared to the (+/+) genotype. Moreover, the (-) allele of PTEN IVS4 polymorphism was also significantly associated with the risk of cancer (OR=1.27, 95% CI=1.14-1.41), especially for digestive cancer (OR=1.42, 95% CI=1.16-1.74) compared to the (+) allele. No significant association was observed between PTEN IVS4 (+/-) genotype and risk of cancer.
  
  
  CONCLUSIONS
  PTEN IVS4 (-/-) genotype was significantly associated with increased risk of cancer especially for digestive tract cancer compared to the (+/+) genotype. A similar phenomenon was observed in the (-) allele of PTEN IVS4 polymorphism compared to the (+) allele and the recessive effect model.
authors.affiliation: Department of Surgery, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, P.R. China 13514212975@163.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Public Health, University of California, San Francisco, CA, U.S.A.
authors.forename: Helen
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of General Surgery, the First Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
authors.forename: J I
authors.initials: JI
authors.lastname: Luo
authors.affiliation: Department of General Surgery, the First Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
authors.forename: Jinnian
authors.initials: J
authors.lastname: Ge
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007438:Introns; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: PTEN; cancer; meta-analysis; polymorphism