title: Genome-wide association study of meat quality traits in chicken.
abstract: Meat quality traits are very important in the poultry industry. To identify single nucleotide polymorphisms (SNPs) and candidate genes affecting meat quality traits, a genome-wide association study was performed using the Illumina chicken 60K SNP beadchip in Jinghai yellow chicken. Four meat quality traits were measured. Two SNPs reached 5% Bonferroni genome-wide significance (P < 1.8E-6) and 7 SNPs reached "suggestive" genome-wide significance (P < 3.59E-6) with meat quality. These SNPs were located nearby or in 7 candidate genes, including CBLN2, HPGDS, SETD2, and ANKRD46, among others. A total of 5650 haplotpyes were established and only 1 was found to be associated with fat content in leg muscle. These results indicate that the 9 SNPs and 7 genes are important candidate markers and may influence meat quality traits in chicken.
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
authors.forename: Q C
authors.initials: QC
authors.lastname: Fan
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
authors.forename: G X
authors.initials: GX
authors.lastname: Zhang
authors.affiliation: Jiangsu Jinghai Industry Poultry Group Co, Ltd., Nantong, Jiangsu, China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Gu
authors.affiliation: College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Tang
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000235:genetics*; D001835:Body Weight / Q000235:genetics*; D002645:Chickens; D005260:Female; D015870:Gene Expression; D055106:Genome-Wide Association Study; D006239:Haplotypes; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics; D019746:Intramolecular Oxidoreductases / Q000235:genetics; D054834:Lipocalins / Q000235:genetics; D008460:Meat; D009124:Muscle Proteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011498:Protein Precursors / Q000235:genetics; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable
chemical_list: D030161:Avian Proteins; D054834:Lipocalins; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; D011498:Protein Precursors; D011495:Histone-Lysine N-Methyltransferase; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase