title: Premature ejaculation: old story, new insights.
abstract: Conventional theories and therapies for premature ejaculation (PE) are based on assumptions not always supported by evidence. This review of the current literature on the physiology of the ejaculatory control, pathogenesis of PE, and available therapies shows that PE is still far from being fully understood. However, several interesting hypotheses have been formulated, and solid, evidence-based clinical data are currently available for dapoxetine, the unique, first-line, officially approved pharmacotherapy for PE. Further growth in the field of PE will occur only when we shift from opinion-based classifications, definitions, and hypotheses to robust, noncontroversial data grounded on evidence.
authors.affiliation: Endocrinology and Medical Sexology, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy. Electronic address: emmanuele.jannini@uniroma2.it.
authors.forename: Emmanuele A
authors.initials: EA
authors.lastname: Jannini
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Ciocca
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Limoncin
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Mollaioli
authors.affiliation: Department of Experimental Medicine, Section of Medical Pathophysiology, Food Sciences, and Endocrinology, Sapienza University of Rome, Rome, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Di Sante
authors.affiliation: Department of Experimental Medicine, Section of Medical Pathophysiology, Food Sciences, and Endocrinology, Sapienza University of Rome, Rome, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Gianfrilli
authors.affiliation: Department of Experimental Medicine, Section of Medical Pathophysiology, Food Sciences, and Endocrinology, Sapienza University of Rome, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Lombardo
authors.affiliation: Department of Experimental Medicine, Section of Medical Pathophysiology, Food Sciences, and Endocrinology, Sapienza University of Rome, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lenzi
mesh_terms: D000818:Animals; D001596:Benzylamines / Q000627:therapeutic use; D004542:Ejaculation / Q000187:drug effects; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008388:Marital Therapy; D009281:Naphthalenes / Q000627:therapeutic use; D010413:Penis / Q000294:innervation*; D061686:Premature Ejaculation / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D020127:Recovery of Function; D012307:Risk Factors; D012701:Serotonin / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012725:Sexual Behavior; D009435:Synaptic Transmission; D016896:Treatment Outcome
chemical_list: D001596:Benzylamines; D006728:Hormones; D009281:Naphthalenes; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; C080598:dapoxetine
keywords: Dapoxetine; premature ejaculation; serotonin