title: Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy.
abstract: A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, No. 1001, Ta-Hsueh Rd., Hsinchu, Taiwan, 300, Republic of China.
authors.forename: Po-Jung
authors.initials: PJ
authors.lastname: Chen
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, No. 1001, Ta-Hsueh Rd., Hsinchu, Taiwan, 300, Republic of China.
authors.forename: Yi-Da
authors.initials: YD
authors.lastname: Kang
authors.affiliation: Center for Neuropsychiatry and Department of Neurology, China Medical University & Hospital, Taichung, Taiwan, 40447, Republic of China.
authors.forename: Chen-Huan
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, No. 1001, Ta-Hsueh Rd., Hsinchu, Taiwan, 300, Republic of China.
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Chen
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, 40402, Republic of China.
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Hsieh
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University, No.155, Sec. 2, Linong St., Taipei, Taiwan, 112, Republic of China.
authors.forename: You-Yin
authors.initials: YY
authors.lastname: Chen
authors.affiliation: Center for Neuropsychiatry and Department of Neurology, China Medical University & Hospital, Taichung, Taiwan, 40447, Republic of China.
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Chiang
authors.affiliation: Center for Neuropsychiatry and Department of Neurology, China Medical University & Hospital, Taichung, Taiwan, 40447, Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lee
authors.affiliation: Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, 40402, Republic of China.
authors.forename: Chung-Y
authors.initials: CY
authors.lastname: Hsu
authors.affiliation: Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, #05-COR, 117456, Singapore.|Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Rd., Zhunan Town, Miaoli County, Taiwan, 35053, Republic of China.
authors.forename: Lun-De
authors.initials: LD
authors.lastname: Liao
authors.affiliation: Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan, 30013, Republic of China.
authors.forename: Chih-Tai
authors.initials: CT
authors.lastname: Fan
authors.affiliation: Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan, 30013, Republic of China.|Institute of Photonics Technologies, National Tsing Hua University, Hsinchu, Taiwan, 30013, Republic of China.
authors.forename: Meng-Lin
authors.initials: ML
authors.lastname: Li
authors.affiliation: Center for Neuropsychiatry and Department of Neurology, China Medical University & Hospital, Taichung, Taiwan, 40447, Republic of China.|Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, 40402, Republic of China.
authors.forename: Woei-Cherng
authors.initials: WC
authors.lastname: Shyu
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003287:Contrast Media / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry; D005434:Flow Cytometry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D043942:Nanotubes / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D011859:Radiography; D020521:Stroke / Q000628:therapy*; D059631:Wharton Jelly / Q000166:cytology
chemical_list: D015703:Antigens, CD; D003287:Contrast Media; D058185:Magnetite Nanoparticles; D006046:Gold; D052203:Ferrosoferric Oxide
keywords: magnetic resonance imaging; mesenchymal stem cells; multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin; photoacoustic imaging; stroke therapy