title: Phosphorus-Based Dendrimer ABP Treats Neuroinflammation by Promoting IL-10-Producing CD4(+) T Cells.
abstract: Dendrimers are polyfunctional nano-objects of perfectly defined structure that can provide innovative alternatives for the treatment of chronic inflammatory diseases, including multiple sclerosis (MS). To investigate the efficiency of a recently described amino-bis(methylene phosphonate)-capped ABP dendrimer as a potential drug candidate for MS, we used the classical mouse model of MOG35-55-induced experimental autoimmune encephalomyelitis (EAE). Our study provides evidence that the ABP dendrimer prevents the development of EAE and inhibits the progression of established disease with a comparable therapeutic benefit as the approved treatment Fingolimod. We also show that the ABP dendrimer redirects the pathogenic myelin-specific CD4(+) T cell response toward IL-10 production.
authors.forename: Myriam
authors.initials: M
authors.lastname: Hayder
authors.forename: Marjorie
authors.initials: M
authors.lastname: Varilh
authors.affiliation: Laboratoire de Chimie de Coordination CNRS UPR8241-205 , route de Narbonne, 31077-BP44099 Toulouse Cedex 4 France.|UPS-INPT, Université de Toulouse , F31077 Toulouse Cedex 4, France.
authors.forename: Cédric-Olivier
authors.initials: CO
authors.lastname: Turrin
authors.forename: Abdelhadi
authors.initials: A
authors.lastname: Saoudi
authors.affiliation: Laboratoire de Chimie de Coordination CNRS UPR8241-205 , route de Narbonne, 31077-BP44099 Toulouse Cedex 4 France.|UPS-INPT, Université de Toulouse , F31077 Toulouse Cedex 4, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Caminade
authors.forename: Rémy
authors.initials: R
authors.lastname: Poupot
authors.forename: Roland S
authors.initials: RS
authors.lastname: Liblau
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy*; D016753:Interleukin-10 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009103:Multiple Sclerosis / Q000188:drug therapy; D010758:Phosphorus / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D050091:Dendrimers; D016753:Interleukin-10; D010758:Phosphorus