title: Utility of F-18 FDG PET/CT on the evaluation of primary bone lymphoma.
abstract: OBJECTIVE
  Primary bone lymphoma (PBL) is a rare type of malignant lymphoma. Few data have been reported regarding the utility of F-18 FDG PET/CT in this disease. The aim of this study was to assess the role of F-18 FDG PET/CT in the diagnosis and therapeutic effect evaluation of PBL.
  
  
  METHODS
  A total of 19 consecutive patients with PBL were enrolled. Whole-body PET/CT scan was performed for all patients. The diagnosis of PBL was established by histopathology and immunohistochemistry.
  
  
  RESULTS
  F-18 FDG PET/CT was positive in 94.7% (18/19) of patients. Uptake of FDG in lesions was intense with SUVmax of 15.14 ± 11.82. Multiple involved lesions were found in 47.4% (9/19) patients, while 52.6% presented with a single involved lesion. Based on the lesions, PET detected 98.9% (87/88) lesions. Among them, 71.6% (63/88) lesions were found to be located in axial skeleton and 28.4% (25/88) in the extremity skeleton. FDG PET/CT also found the lesions infiltrate to the surrounding soft tissue in 84.2% (16/19) patients. On the syn-modality CT, the bone destruction was noted in 43.2% (38/88) of the lesions, of which 50.0% lesions presented as slight change in bone density and 50.0% as severe change. The diagnostic sensitivity of PET was much higher than that of CT (98.9% vs. 43.2%, P=0.000). PET/CT was performed for evaluation of treatment response in 13 patients. In 12 patients with complete response(CR), PET/CT found the 25 lesions were F-18 FDG fully resoluted after treatment, however, bone destruction was still presented in 72.0% (18/25) lesions.
  
  
  CONCLUSIONS
  The present study suggests that F-18 FDG PET/CT was a sensitive imaging modality for diagnosis and treatment response evaluation of PBL.
authors.affiliation: NanFang PET/CT Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong Province 510515, China. Electronic address: wljhaiyin@163.com.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: NanFang PET/CT Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong Province 510515, China. Electronic address: wuhbym@163.com.
authors.forename: Hu-Bing
authors.initials: HB
authors.lastname: Wu
authors.affiliation: NanFang PET/CT Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong Province 510515, China. Electronic address: wangmnge@gmail.com.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: NanFang PET/CT Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong Province 510515, China. Electronic address: riverhanyj@gmail.com.
authors.forename: Yan-Jiang
authors.initials: YJ
authors.lastname: Han
authors.affiliation: NanFang PET/CT Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong Province 510515, China. Electronic address: lhs0425@126.com.
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Li
authors.affiliation: NanFang PET/CT Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong Province 510515, China. Electronic address: wenlanzhou@163.com.
authors.forename: Wen-Lan
authors.initials: WL
authors.lastname: Zhou
authors.affiliation: NanFang PET/CT Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong Province 510515, China. Electronic address: wqslph@163.net.
authors.forename: Quan-Shi
authors.initials: QS
authors.lastname: Wang
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis*; D005121:Extremities / Q000000981:diagnostic imaging; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D051598:Whole Body Imaging
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Computed tomography; Diagnosis; F-18 FDG; Positron emission tomography; Primary bone lymphoma; Treatment response evaluation