title: A convenient method for the preparation of radioiodinated meta-iodobenzylguanidine at a no-carrier-added level.
abstract: Radioiodinated meta-iodobenzylguanidine (MIBG) in high effective specific activity was prepared using 3-tributylstannylbenzylguanidine as the precursor. The labeling was carried out in aqueous solution with the insoluble and lyophilized precursor suspended in the solvent. Simply by filtration, the starting material and by-products were readily separated from the labeled solution. Less than 1.15 ppb tin has remained in the filtrate as determined by the atom fluorescence spectrometry. By this approach, high specific activity (3.4 GBq/µmol) [(131)I]MIBG was obtained in 72.3 ± 3% (n = 3) radiochemical yield and 97.3 ± 2% (n = 3) radiochemical purity. The whole preparation could be finished in less than 10 min. According to this method, a kit for the preparation of (123)I-MIBG and (131)I-MIBG is currently being developed.
authors.affiliation: Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu, China.
authors.forename: Erming
authors.initials: E
authors.lastname: Wu
authors.affiliation: Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu, China.
authors.forename: Heyun
authors.initials: H
authors.lastname: Huang
mesh_terms: D019797:3-Iodobenzylguanidine / Q000138:chemical synthesis*; D007457:Iodine Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine
keywords: destannylation; lyophilization; meta-iodobenzylguanidine; no-carrier-added