title: Mathematical study of probe arrangement and nanoparticle injection effects on heat transfer during cryosurgery.
abstract: Blood vessels, especially large vessels have a greater thermal effect on freezing tissue during cryosurgery. Vascular networks act as heat sources in tissue, and cause failure in cryosurgery and reappearance of cancer. The aim of this study is to numerically simulate the effect of probe location and multiprobe on heat transfer distribution. Furthermore, the effect of nanoparticles injection is studied. It is shown that the small probes location near large blood vessels could help to reduce the necessary time for tissue freezing. Nanoparticles injection shows that the thermal effect of blood vessel in tissue is improved. Using Au, Ag and diamond nanoparticles have the most growth of ice ball during cryosurgery. However, polytetrafluoroethylene (PTFE) nanoparticle can be used to protect normal tissue around tumor cell due to its influence on reducing heat transfer in tissue. Introduction of Au, Ag and diamond nanoparticles combined with multicryoprobe in this model causes reduction of tissue average temperature about 50% compared to the one probe.
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Iran.
authors.forename: Seyyed Mostafa
authors.initials: SM
authors.lastname: Mirkhalili
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Iran. Electronic address: Ramazani@sharif.edu.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ramazani S A
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Nazemidashtarjandi
mesh_terms: D000465:Algorithms; D001808:Blood Vessels / Q000473:pathology; D003452:Cryosurgery / Q000379:methods*; D018130:Diamond / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006358:Hot Temperature; D006801:Humans; D008962:Models, Theoretical; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009369:Neoplasms / Q000601:surgery; D011138:Polytetrafluoroethylene / Q000737:chemistry; D012834:Silver / Q000737:chemistry
chemical_list: D012834:Silver; D006046:Gold; D018130:Diamond; D011138:Polytetrafluoroethylene
keywords: Cryosurgery; Large blood vessels; Multicryoprobe; Nanotechnology; Thermal effect