title: Plasma 25-hydroxyvitamin D deficiency is associated with the risk of non-small cell lung cancer in a Chinese population.
abstract: BACKGROUND
  The association between vitamin D levels and lung cancer risk varies among distinct demographic populations; however, whether vitamin D levels are related to the risk of lung cancer in Chinese population is unknown.
  
  
  OBJECTIVE
  We aimed to elucidate the association of plasma 25-hydroxyvitamin D [25(OH)D] level with the risk of non-small cell lung cancer (NSCLC) in a Chinese population.
  
  
  METHODS
  A total of 100 NSCLC patients and, 100 age-, gender-, blood-collection-season- and resident area-matched, cancer-free controls were recruited. Plasma 25(OH)D2 and 25(OH)D3 levels were measured by LC/MS/MS mass spectrometry and HPLC. A logistic regression model was applied to estimate the association between 25(OH)D concentrations and NSCLC risk.
  
  
  RESULTS
  Multivariable analysis showed that smoking history, and 25(OH)D deficiency (< 20 ng/mL) were related to a higher risk of NSCLC (P = 0.03). In addition, late stage (stage IIIB-IV) NSCLC was associated with lower 25(OH)D levels, as indicated by univariate analysis. Similarly, multivariate analysis showed that late stage (IIIB-IV) NSCLC was related to 25(OH)D deficiency.
  
  
  CONCLUSIONS
  Plasma 25(OH)D deficiency is significantly associated with a higher risk of NSCLC, specifically late stage NSCLC.
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Jiuwei
authors.initials: J
authors.lastname: Cui
authors.affiliation: Clinical Pharmacology Center, Research Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin, China.|Research Center for Drug Metabolism, Jilin University, Changchun, Jilin, China.
authors.forename: Jingkai
authors.initials: J
authors.lastname: Gu
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Hua
authors.initials: H
authors.lastname: He
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Li
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012307:Risk Factors; D053719:Tandem Mass Spectrometry; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-hydroxyvitamin D; lung cancer; non-small cell lung cancer