title: GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases.
abstract: Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of 'Western lifestyle' diseases.
authors.affiliation: Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
authors.forename: Craig I
authors.initials: CI
authors.lastname: McKenzie
authors.affiliation: Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia; Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA. Electronic address: charles.mackay@pfizer.com.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Mackay
authors.affiliation: Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia; Charles Perkins Centre, The University of Sydney, NSW 2006, Australia; School of Medical Sciences, The University of Sydney, NSW 2006, Australia. Electronic address: laurence.macia@monash.edu.
authors.forename: Laurence
authors.initials: L
authors.lastname: Macia
mesh_terms: D000818:Animals; D005232:Fatty Acids, Volatile / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*
chemical_list: D005232:Fatty Acids, Volatile; D043562:Receptors, G-Protein-Coupled
keywords: Fiber; GPR43; SCFAs; inflammation; metabolism