title: Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives.
abstract: A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2μM, it was better than 5-FU (59.3μΜ, 18.4μM respectively).
authors.forename: Yun
authors.initials: Y
authors.lastname: Wei
authors.forename: Qutong
authors.initials: Q
authors.lastname: Zheng
authors.forename: Guotao
authors.initials: G
authors.lastname: Tang
authors.forename: Chen
authors.initials: C
authors.lastname: Song
authors.forename: Guan
authors.initials: G
authors.lastname: Wang
authors.forename: Yinxiang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.forename: Xianliang
authors.initials: X
authors.lastname: Zeng
authors.forename: Zongbao
authors.initials: Z
authors.lastname: Wang
authors.forename: Jichang
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Institute of Pharmacy & Pharmacology, University of South China, Hengyang, 421001, China. zhengxing5018@yahoo.com.
authors.forename: Xing
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D047309:Flavones / Q000138:chemical synthesis / Q000494:pharmacology*; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D007462:Iodobenzenes / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure; D012118:Resorcinols / Q000138:chemical synthesis / Q000494:pharmacology*; D013964:Thyroid Neoplasms
chemical_list: C000621020:2-(3-iodophenyl)-7-(pentyloxy)-4H-chromen-4-one; C000621021:7-(hexyloxy)-2-(3-iodophenyl)-4H-chromen-4-one; D000970:Antineoplastic Agents; D047309:Flavones; D007462:Iodobenzenes; D012118:Resorcinols; D005472:Fluorouracil; C031389:resorcinol