title: Effectiveness of GK-2, a Nerve Growth Factor Mimetic, in Preventing Post-Resuscitation Changes in the Brain.
abstract: Neurological status was assessed and the numbers of neurons per 1 mm in pyramidal neuronal layer length in CA1 and CA4 hippocampal fields and cerebellar Purkinje cells were evaluated in albino male rats on post-resuscitation day 14 after 12-min cardiac arrest. Intraperitoneal administration of GK-2 (1 mg/kg 30 min after resuscitation and within the next 3 days with an interval of 24 h) accelerated neurological recovery of the animals, sharply reduced the intensity of cerebellar Purkinje cell death, and prevented loss of pyramidal neurons in the hippocampus. These results show the effectiveness of systemic administration of the nerve growth factor mimetic GK-2 in improving structural and functional state of the brain in the post-resuscitation period. This opens new prospects of its use for prevention and correction of post-hypoxic encephalopathy.
authors.affiliation: V. A. Negovsky Research Institute of General Resuscitation, Moscow, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Zarzhetskii
authors.affiliation: V. A. Negovsky Research Institute of General Resuscitation, Moscow, Russia. maria_avr@mail.ru.
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Avrushchenko
authors.affiliation: V. A. Negovsky Research Institute of General Resuscitation, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Moroz
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000473:pathology; D002531:Cerebellum / Q000187:drug effects / Q000473:pathology; D018891:Dentate Gyrus / Q000187:drug effects / Q000473:pathology; D004151:Dipeptides / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D008297:Male; D018716:Molecular Mimicry; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects / Q000473:pathology; D051381:Rats; D020127:Recovery of Function; D012151:Resuscitation
chemical_list: D004151:Dipeptides; D018696:Neuroprotective Agents; C572946:bis(N-succinyl-glutamyllysin)hexamethylenediamine
keywords: nerve growth factor mimetic GK-2; neurological recovery; neuronal death; post-resuscitation period