title: Postprandial insulin and glucose levels are reduced in healthy subjects when a standardised breakfast meal is supplemented with a filtered sugarcane molasses concentrate.
abstract: OBJECTIVE
  A phytochemical- and mineral-rich filtered sugarcane molasses concentrate (FMC), when added to carbohydrate-containing foods as a functional ingredient, lowers postprandial blood glucose and insulin responses. We hypothesised that this beneficial effect would also occur if FMC was administered as an oral supplement taken before a meal.
  
  
  METHODS
  This study measured the postprandial glucose and insulin responses elicited by different doses of FMC administered immediately prior to a standard breakfast to healthy subjects. Each subject was given three or five breakfast meals once, on different days. The composition of the meals was identical, except for the addition of either placebo syrup (test meal 1) or increasing doses of FMC (test meals 2-5).
  
  
  RESULTS
  The plasma glucose concentration curves were similar for the five test meals. Plasma insulin curves were lowered in a dose-dependent manner. Stratifying subjects based on age, BMI and insulin resistance showed greater effects of low doses of FMC on lowering insulin responses in those subjects with potentially greater insulin resistance. When insulin response is standardised to amount of carbohydrate in the meal/dose combination, the reduction in response is linear and inversely proportional to the FMC dose.
  
  
  CONCLUSIONS
  FMC shows promise as an agent that can reduce insulin responses and lessen the load on the pancreatic beta cells.
authors.affiliation: Horizon Science Pty. Ltd., 6/84-90 Lakewood Blvd., Braeside, VIC, 3195, Australia. tim.ellis@horizonscience.com.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Ellis
authors.affiliation: Horizon Science Pty. Ltd., 6/84-90 Lakewood Blvd., Braeside, VIC, 3195, Australia.
authors.forename: Alison G
authors.initials: AG
authors.lastname: Wright
authors.affiliation: Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, VIC, 3004, Australia.|School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Frome Road, Adelaide, SA, 5000, Australia.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Clifton
authors.affiliation: Horizon Science Pty. Ltd., 6/84-90 Lakewood Blvd., Braeside, VIC, 3195, Australia.|Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Rd, Parkville, VIC, 3010, Australia.
authors.forename: Leodevico L
authors.initials: LL
authors.lastname: Ilag
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D062408:Breakfast; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000032:analysis; D004041:Dietary Fats / Q000008:administration & dosage / Q000032:analysis; D004043:Dietary Fiber / Q000008:administration & dosage / Q000032:analysis; D004044:Dietary Proteins / Q000008:administration & dosage / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage / Q000032:analysis; D008965:Molasses / Q000032:analysis*; D064209:Phytochemicals / Q000008:administration & dosage / Q000032:analysis; D019518:Postprandial Period; D031786:Saccharum / Q000737:chemistry*; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D004044:Dietary Proteins; D007328:Insulin; D018977:Micronutrients; D064209:Phytochemicals
keywords: Blood glucose; Insulin; Insulin resistance; Metabolic syndrome