title: A fluorescent probe for H2S in vivo with fast response and high sensitivity.
abstract: In this work, we design and synthesize a new near-infrared (NIR) ratiometric fluorescent probe FD-H2S for the highly sensitive (DL 68.2 nM) detection of H2S with fast response (15 s), large emission shift (220 nm) and excellent enhancement (168-fold in ratiometric value). The probe could be applied for monitoring and imaging of exogenous or endogenous H2S in live MCF-7 cells and in live mice with the fastest response.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China. pengxj@dlut.edu.cn.
authors.forename: H D
authors.initials: HD
authors.lastname: Li
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China. pengxj@dlut.edu.cn.
authors.forename: Q C
authors.initials: QC
authors.lastname: Yao
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China. pengxj@dlut.edu.cn.
authors.forename: J L
authors.initials: JL
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China. pengxj@dlut.edu.cn.
authors.forename: N
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Department School of life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116024, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Department School of life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116024, China.
authors.forename: J
authors.initials: J
authors.lastname: Xia
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China. pengxj@dlut.edu.cn.
authors.forename: X J
authors.initials: XJ
authors.lastname: Peng
mesh_terms: D000818:Animals; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis* / Q000737:chemistry; D061986:MCF-7 Cells; D051379:Mice
chemical_list: D005456:Fluorescent Dyes; D006862:Hydrogen Sulfide