title: What Evidence Is There That Gadobutrol Causes Increasing Signal Intensity within the Dentate Nucleus and Globus Pallidus on Unenhanced T1W MRI in Patients with RRMS?
abstract: KEY POINTS : The study by Stojanov et al does not convincingly support the conclusion that gadobutrol causes higher T1 enhancement in brain on unenhanced MRI. The study by Stojanov et al does not rule out confounding factors . The study by Stojanov et al has limitations in study design.
authors.affiliation: Global Medical & Clinical Affairs Radiology, Bayer HealthCare, 100 Bayer Boulevard, Whippany, NJ, 07981, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Agris
authors.affiliation: MR & CT Contrast Media Research, Bayer HealthCare, Whippany, NJ, USA.
authors.forename: Hubertus
authors.initials: H
authors.lastname: Pietsch
authors.affiliation: Global Medical & Clinical Affairs Radiology, Bayer HealthCare, 100 Bayer Boulevard, Whippany, NJ, 07981, USA. thomas.balzer@bayer.com.
authors.forename: Thomas
authors.initials: T
authors.lastname: Balzer
mesh_terms: D001921:Brain; D002529:Cerebellar Nuclei; D005917:Globus Pallidus; D006801:Humans; D008279:Magnetic Resonance Imaging
keywords: Dentate nucleus; Gadobutrol; Globus pallidus; Signal intensity on unenhanced MRI