title: Renal function and diffusion-weighted imaging: a new method to diagnose kidney failure before losing half function.
abstract: OBJECTIVE
  To diagnose earlier kidney failure, we investigated renal functions with diffusion-weighted imaging (DWI).
  
  
  METHODS
  We evaluated the DWI of 62 patients with chronic kidney disease (CKD) and compared it with creatinine clearance provided by daily urine collection. The apparent diffusion coefficient (ADC) values were compared with the five stages of CKD.
  
  
  RESULTS
  For each stage of CKD, the ADC values were found to be significantly different (p < 0.01) and allowed the differentiation of stage 1 of the disease from the other stages.
  
  
  CONCLUSIONS
  Renal ADC values show a significant correlation with the clinical stages of CKD. DWI may detect renal failure prior to a rise in creatinine.
authors.affiliation: Department of Nephrology, Istanbul Research and Training Hospital, Istanbul, Turkey. aturkeremre@yahoo.com.tr.
authors.forename: Türker
authors.initials: T
authors.lastname: Emre
authors.affiliation: Department of Radyology, Istanbul Research and Training Hospital, Istanbul, Turkey. okilickesmez@yahoo.com.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kiliçkesmez
authors.affiliation: Department of Radyology, Istanbul Research and Training Hospital, Istanbul, Turkey. atilaybuker@gmail.com.
authors.forename: Atılay
authors.initials: A
authors.lastname: Büker
authors.affiliation: Department of Biochemistry, Istanbul Research and Training Hospital, Istanbul, Turkey. berrin_inal@yahoo.com.
authors.forename: Berrin Berçik
authors.initials: BB
authors.lastname: İnal
authors.affiliation: Fatih Private Hemodialysis Unite, Istanbul, Turkey. huseyindogan@yahoo.com.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Doğan
authors.affiliation: Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul University, Fatih, Istanbul, Turkey. tevfikecder@yahoo.com.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ecder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000503:physiopathology / Q000652:urine; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D003404:Creatinine
keywords: Diffusion-weighted imaging; Kidney failure; Renal function