title: Daptomycin Use in United States Children's Hospitals.
abstract: We described 1035 pediatric hospitalizations with daptomycin use in 794 patients since 2004. Daptomycin use was uncommon but increased over time. A minority of hospitals accounted for the majority of use. This variability of daptomycin use highlights the need for future studies to assess the efficacy and safety of daptomycin in children.
authors.affiliation: Division of Infectious Diseases.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Larru
authors.affiliation: The Center for Pediatric Effectiveness, The Children's Hospital of Philadelphia.
authors.forename: Carter L
authors.initials: CL
authors.lastname: Cowden
authors.affiliation: Division of Infectious Diseases The Center for Pediatric Effectiveness, The Children's Hospital of Philadelphia Perelman School of Medicine, University of Pennsylvania, Philadelphia.
authors.forename: Theoklis E
authors.initials: TE
authors.lastname: Zaoutis
authors.affiliation: Division of Infectious Diseases The Center for Pediatric Effectiveness, The Children's Hospital of Philadelphia Perelman School of Medicine, University of Pennsylvania, Philadelphia.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Gerber
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D017576:Daptomycin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D014481:United States / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin
keywords: MRSA; VRE; children; daptomycin; resistance