title: Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders.
abstract: Two new examples of uncommon three-dimensional Ca-bearing metal organic frameworks, [Ca(H2O)3(HPXBP)] (CaP1) and [Ca2(H2O)2(HPXBP)1.5] (CaP2) (PXBP: p-xylylenebisphosphonate), were prepared and their structures characterized by single crystal X-ray diffraction. CaP1 crystallizes in the monoclinic C2/c space group, with three water molecules occupying a half coordination sphere on one side of the Ca atom, while CaP2 crystallizes in the triclinic P1̅ space group, with two crystallographic unique Ca atoms, each coordinated by a single water molecule. In contrast with CaP2, which exhibits very low bioactivity, CaP1 readily precipitates bone-precursor phases (octacalcium phosphate, OCP, and hydroxyapatite) in SBF solutions. Moreover, studies with MG63 osteoblast-like cells indicate that CaP1 is not toxic and stimulates bone mineralization and, thus, holds considerable potential for treating bone diseases, such as osteoporosis.
authors.affiliation: School of Science, Shenyang University of Technology , 110870 Shenyang, China.
authors.forename: Fa-Nian
authors.initials: FN
authors.lastname: Shi
authors.forename: José C
authors.initials: JC
authors.lastname: Almeida
authors.affiliation: Organic Chemistry and Natural Products Unit (QOPNA), Department of Chemistry, University of Aveiro , 3810-193 Aveiro, Portugal.|Institute for Research in Biomedicine-iBiMED, Health Sciences Program, University of Aveiro , 3810-193 Aveiro, Portugal.
authors.forename: Luisa A
authors.initials: LA
authors.lastname: Helguero
authors.forename: Maria H V
authors.initials: MH
authors.lastname: Fernandes
authors.affiliation: Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London , London, WC1X 8LD, United Kingdom.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Knowles
authors.forename: João
authors.initials: J
authors.lastname: Rocha
mesh_terms: D001847:Bone Diseases / Q000188:drug therapy*; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D002130:Calcium Phosphates