title: Synthesis, Cytotoxic and Contraceptive Activity of 6,8,9-Trihydroxy-2-methyl-2H-naphtho[2,3-b]pyran-5,10-dione, a Pigment of Echinothrix diadema, and its Analogs.
abstract: 6,8,9-Trihydroxy-2-methyl-2H-naphtho[2,3-b]pyran-5,10-dion, a pigment of the sea urchin Echinothrix diadema, and six analogs were synthesized. The cytotoxic activity and contraceptive properties of the synthesized pyranonaphthazarins have been investigated using the sperm and eggs of the sea urchin Strongylocentrotus intermedius.
authors.forename: Natalia D
authors.initials: ND
authors.lastname: Pokhilo
authors.forename: Galina I
authors.initials: GI
authors.lastname: Melman
authors.forename: Marina I
authors.initials: MI
authors.lastname: Kiseleva
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.forename: Victor Ph
authors.initials: VP
authors.lastname: Anufriev
mesh_terms: D000818:Animals; D003270:Contraceptive Agents / Q000138:chemical synthesis* / Q000633:toxicity; D008297:Male; D009285:Naphthoquinones / Q000737:chemistry* / Q000633:toxicity; D010063:Ovum / Q000187:drug effects; D010860:Pigments, Biological / Q000737:chemistry* / Q000633:toxicity; D011753:Pyrones / Q000032:analysis / Q000138:chemical synthesis* / Q000633:toxicity; D012617:Sea Urchins / Q000737:chemistry*; D013094:Spermatozoa / Q000187:drug effects
chemical_list: C000602653:6,8,9-trihydroxy-2-methyl-2H-naphtho(2,3-b)pyran-5,10-dione; D003270:Contraceptive Agents; D009285:Naphthoquinones; D010860:Pigments, Biological; D011753:Pyrones