title: Cytomegalovirus Reactivation in Adult Recipients of Autologous Stem Cell Transplantation: a Single Center Experience.
abstract: BACKGROUND
  Cytomegalovirus (CMV) reactivation and infection are well-recognized complications after allogeneic stem cell transplantation (SCT). Only a few studies have addressed CMV reactivation after autologous SCT (ASCT).
  
  
  METHODS
  We retrospectively reviewed medical records of 210 adult patients who underwent ASCT for lymphoma or multiple myeloma (MM) at a single center from January 1(st), 2007 until December 31(st), 2012. All patients were monitored weekly with CMV antigenemia test till day 42 after transplantation, and for 2 months after last positive test in those who had any positive CMV antigenemia test before day 42.
  
  
  RESULTS
  Thirty-seven (17.6%) patients had CMV reactivation; 23 patients had lymphoma while 14 had MM as the underlying disease. There was no difference in the rate of CMV reactivation between lymphoma and MM patients (20% versus 14.7%, P = 0.32). The majority of the patients were treated with ganciclovir/valganciclovir, all patients had their reactivation resolved with therapy, and none developed symptomatic CMV infection. None of the patients who died within 100 days of transplantation had CMV reactivation. Log-rank test showed that CMV reactivation had no effect on the overall survival of patients (P values, 0.29).
  
  
  CONCLUSIONS
  In our cohort, CMV reactivation rate after ASCT was 17.6%. There was no difference in reactivation rates between lymphoma and MM patients. With the use of preemptive therapy, symptomatic CMV infection was not documented in any patient in our cohort. CMV reactivation had no impact on patients' survival post ASCT.
authors.affiliation: Stem cell & bone marrow transplantation program, King Hussein Cancer Center, Amman, Jordan.
authors.forename: Omar
authors.initials: O
authors.lastname: Al-Rawi
authors.affiliation: Stem cell & bone marrow transplantation program, King Hussein Cancer Center, Amman, Jordan.
authors.forename: Fawzi
authors.initials: F
authors.lastname: Abdel-Rahman
authors.affiliation: Stem cell & bone marrow transplantation program, King Hussein Cancer Center, Amman, Jordan.
authors.forename: Rula
authors.initials: R
authors.lastname: Al-Najjar
authors.affiliation: Stem cell & bone marrow transplantation program, King Hussein Cancer Center, Amman, Jordan.
authors.forename: Husam
authors.initials: H
authors.lastname: Abu-Jazar
authors.affiliation: Stem cell & bone marrow transplantation program, King Hussein Cancer Center, Amman, Jordan.
authors.forename: Mourad
authors.initials: M
authors.lastname: Salam
authors.affiliation: Division of Infectious Diseases, Prince Sultan Cardiac Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Saad