title: [A case-control study on association between OAS1 polymorphism and susceptibility to spontaneous preterm birth and preterm premature rupture of membranes].
abstract: OBJECTIVE
  To investigate the association between the genetic polymorphism of 2',5'-oligoadenylate synthetase 1 (OAS1) and susceptibility to spontaneous preterm birth (SPTB) and preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  The case-control study consisted of 599 preterm infants including 171 cases of PPROM, and 673 full-term infants without maternal histories of SPTB and PPROM as controls. The single nucleotide polymorphism (SNP) at OAS1 intron 5, rs10774671, was analyzed by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  No significant differences were observed between the case and control groups in the frequencies of genotypes (AA, GA, and GG) and alleles (A and G) of OAS1 rs10774671. When the case group was divided into two subgroups with or without PPROM, no significant differences in the genotype and allele frequencies were found between each subgroup and the control group. When the case group was divided into three subgroups with different gestational ages at SPTB, no significant differences in the genotype and allele frequencies were detected between each subgroup and the control group.
  
  
  CONCLUSIONS
  No association is identified between OAS1 SNP and susceptibility to SPTB and PPROM.
authors.affiliation: Developmental Biology Laboratory, Baiyi Childrenγs Hospital Affiliated to Beijing Military General Hospital, Beijing 100700, China. 001wangyan@sina.com.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.forename: Xiao-Ai
authors.initials: XA
authors.lastname: Zhang
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020641:Polymorphism, Single Nucleotide; D047928:Premature Birth / Q000235:genetics*
chemical_list: C475085:OAS1 protein, human; D015088:2',5'-Oligoadenylate Synthetase