title: Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract.
abstract: Through dereplication analysis, seven known Mammea coumarins were identified in a fraction obtained from Mammea neurophylla dichloromethane bark extract selected for its ability to prevent advanced glycation end-product (AGE) formation. Among them, a careful examination of the NMR dataset of pedilanthocoumarin B led to a structural revision. Inspection of LC-DAD-MS(n) chromatograms allowed us to predict the presence of four new compounds, which were further isolated. Using spectroscopic methods (¹H-, (13)C- and 2D-NMR, HRMS, UV), these compounds were identified as new benzoyl substituted 4-phenylcoumarins (iso-pedilanthocoumarin B and neurophyllol C) and 4-(1-acetoxypropyl)coumarins cyclo F (ochrocarpins H and I).
authors.affiliation: EA 921 SONAS, Université D'Angers, SFR QUASAV 4207, Campus du Végétal, 42, rue Georges Morel, Beaucouzé 49070, France. taihoa1@gmail.com.
authors.forename: Bach Tai
authors.initials: BT
authors.lastname: Dang
authors.affiliation: EA 921 SONAS, Université D'Angers, SFR QUASAV 4207, Campus du Végétal, 42, rue Georges Morel, Beaucouzé 49070, France. caroline.rouger@univ-angers.fr.
authors.forename: Caroline
authors.initials: C
authors.lastname: Rouger
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 1, av. de la Terrasse, Gif-sur-Yvette 91198, France. marc.litaudon@cnrs.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.affiliation: EA 921 SONAS, Université D'Angers, SFR QUASAV 4207, Campus du Végétal, 42, rue Georges Morel, Beaucouzé 49070, France. pascal.richomme@univ-angers.fr.
authors.forename: Pascal
authors.initials: P
authors.lastname: Richomme
authors.affiliation: EA 921 SONAS, Université D'Angers, SFR QUASAV 4207, Campus du Végétal, 42, rue Georges Morel, Beaucouzé 49070, France. denis.seraphin@univ-angers.fr.
authors.forename: Denis
authors.initials: D
authors.lastname: Séraphin
authors.affiliation: EA 921 SONAS, Université D'Angers, SFR QUASAV 4207, Campus du Végétal, 42, rue Georges Morel, Beaucouzé 49070, France. severine.derbre@univ-angers.fr.
authors.forename: Séverine
authors.initials: S
authors.lastname: Derbré
mesh_terms: D003374:Coumarins / Q000737:chemistry*; D031252:Mammea / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D003374:Coumarins; D010936:Plant Extracts; C094411:4-phenylcoumarin
keywords: 4-(1-acetoxypropyl)coumarins; 4-phenylcoumarins; Calophyllaceae; benzoylcoumarins; dereplication analysis