title: Nitric oxide- and cisplatin-releasing silica nanoparticles for use against non-small cell lung cancer.
abstract: Nitric oxide (NO) and cisplatin releasing wrinkle-structured amine-modified mesoporous silica (AMS) nanoparticles have been developed for the treatment of non-small cell lung cancer (NSCLC). The AMS and NO- and cisplatin-loaded AMS materials were characterized using TEM, BET surface area, FTIR and ICP-MS, and tested in cell culture. The results show that for NSCLC cell lines (i.e., H596 and A549), the toxicity of NO- and cisplatin-loaded silica nanoparticles (NO-Si-DETA-cisplatin-AMS) is significantly higher than that of silica nanoparticles loaded with only cisplatin (Si-DETA-cisplatin-AMS). In contrast, the toxicity of NO-Si-DETA-cisplatin-AMS toward normal lung cell lines is not significantly different from that of Si-DETA-cisplatin-AMS (normal lung fibroblast cells WI-38) or is even lower than that of Si-DETA-cisplatin-AMS (normal lung epithelial cells BEAS-2B). The NO-induced sensitization of tumor cell death demonstrates that NO is a promising enhancer of platinum-based lung cancer therapy.
authors.affiliation: Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, United States.
authors.forename: Imalka
authors.initials: I
authors.lastname: Munaweera
authors.affiliation: Depatment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Depatment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States.
authors.forename: Bhuvaneswari
authors.initials: B
authors.lastname: Koneru
authors.affiliation: Depatment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States.
authors.forename: Amit
authors.initials: A
authors.lastname: Patel
authors.affiliation: Depatment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States.
authors.forename: Mai H
authors.initials: MH
authors.lastname: Dang
authors.affiliation: Depatment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States. Electronic address: Anthony.DiPasqua@unthsc.edu.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Di Pasqua
authors.affiliation: Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, United States. Electronic address: Balkus@utdallas.edu.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Balkus
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D009569:Nitric Oxide / Q000627:therapeutic use / Q000633:toxicity; D020030:Nitric Oxide Donors / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D010316:Particle Size; D011073:Polyamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D020030:Nitric Oxide Donors; D011073:Polyamines; C005391:diethylenetriamine; D009569:Nitric Oxide; D012822:Silicon Dioxide; D002945:Cisplatin
keywords: Cisplatin; Mesoporous silica nanoparticles; Nitric oxide; Non-small cell lung cancer