title: MRI and planimetric CT follow-up study of patients with severe tick-borne encephalitis.
abstract: BACKGROUND
  The aim of the study was to evaluate the magnetic resonance imaging (MRI) and planimetric computed tomography (CT) of brain lesions in patients with a history of tick-borne encephalitis (TBE); to assess the influence of steroid treatment on the brain and whether lesions were age-dependent.
  
  
  METHODS
  A total of 19 patients with abnormal initial imaging in the acute stage of the disease had a follow-up MRI after 1 year; 34 patients hospitalized for TBE encephalitis/encephalomyelitis had planimetric CT after 10 years.
  
  
  RESULTS
  On MRI cortico-subcortical atrophy with widening of anterior horns of the lateral ventricles and vascular changes was more marked on follow-up examination. Virchow-Robin spaces dilatation, widening of the lateral ventricles, periventricular lesions, and cortico-subcortical atrophy correlated with age. Results of planimetric CT study showed increased percentage of tracings, widened anterior horns, lateral ventricles, and III ventricle, which suggest new non-age-related atrophic lesions.
  
  
  CONCLUSIONS
  Radiological lesions in the acute phase of TBE and after recovery are non-specific. Cortico-subcortical atrophy with widening of the anterior horns of the lateral ventricles and vascular changes are most common. Long-term follow-up confirms the formation of new non-age-related cerebral atrophic lesions due to TBE. The logit model may serve as a background for the hypothesis concerning an accelerated local atrophy of the brain tissues in patients with a history of severe TBE.
authors.affiliation: a From the Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Białystok , Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Czupryna
authors.affiliation: b Bialystok Centre for Diagnostic Imaging , Białystok , Poland.
authors.forename: Eugeniusz
authors.initials: E
authors.lastname: Tarasow
authors.affiliation: a From the Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Białystok , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Moniuszko-Malinowska
authors.affiliation: a From the Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Białystok , Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Pancewicz
authors.affiliation: c Faculty of Applied Informatics and Mathematics, Warsaw University of Life Sciences SGGW , Warsaw , Poland.
authors.forename: Olga
authors.initials: O
authors.lastname: Zajkowska
authors.affiliation: d Białystok Centre of Oncology , Białystok , Poland.
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Targoński
authors.affiliation: e Department of Neurology , University Hospital of Bialystok , Białystok , Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Chorąży
authors.affiliation: f Department of Allergy , Cambridge University Hospital , Cambridge , UK.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Rutkowski
authors.affiliation: a From the Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Białystok , Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Dunaj
authors.affiliation: a From the Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Białystok , Poland.
authors.forename: Sambor
authors.initials: S
authors.lastname: Grygorczuk
authors.affiliation: a From the Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Białystok , Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Kondrusik
authors.affiliation: a From the Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Białystok , Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Zajkowska
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000473:pathology; D002648:Child; D004675:Encephalitis, Tick-Borne / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000821:virology; D004679:Encephalomyelitis / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: MRI; brain atrophy; encephalitis; neuroimaging; planimetric CT