title: Associations between single nucleotide polymorphisms and carcass traits in Nellore cattle using high-density panels.
abstract: The objective of this study was to evaluate associations between single nucleotide polymorphism (SNP) markers and carcass traits measured postmortem in Nellore cattle. Records of loin eye area (LEA) and backfat thickness (BF) from 740 males and records of hot carcass weight (HCW) from 726 males were analyzed. All of the animals were genotyped using the BovineHD BeadChip. Association analyses were performed by the restricted maximum likelihood method that considered one SNP at a time. Significant SNPs were identified on chromosomes 2 and 6 for LEA and on chromosomes 7, 1, and 2 for BF. For HCW, associations with SNPs were found on chromosomes 13, 14, and 28, in addition to genome regions that were directly related to this trait, such as the EFCAB8 and VSTM2L genes, and to bone development (RHOU). Some SNPs were located in very close proximity to genes involved in basal metabolism (BLCAP, NNAT, CTNNBL1, TGM2, and LOC100296770) and the immune system (BPI).
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: R
authors.initials: R
authors.lastname: Espigolan
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: F
authors.initials: F
authors.lastname: Baldi
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: A A
authors.initials: AA
authors.lastname: Boligon
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: F R P
authors.initials: FR
authors.lastname: Souza
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: G A
authors.initials: GA
authors.lastname: Fernandes Júnior
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: D G M
authors.initials: DG
authors.lastname: Gordo
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: G C
authors.initials: GC
authors.lastname: Venturini
authors.forename: G M F
authors.initials: GM
authors.lastname: de Camargo
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: F L B
authors.initials: FL
authors.lastname: Feitosa
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: D A
authors.initials: DA
authors.lastname: Garcia
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: H
authors.initials: H
authors.lastname: Tonhati
authors.affiliation: Departamento de Melhoramento e Nutrição Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, SP, Brasil.
authors.forename: L A L
authors.initials: LA
authors.lastname: Chardulo
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: H N
authors.initials: HN
authors.lastname: Oliveira
authors.affiliation: Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP, Brasil.
authors.forename: L G
authors.initials: LG
authors.lastname: Albuquerque
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics; D002417:Cattle / Q000235:genetics / Q000254:growth & development; D063427:Food Quality; D005787:Gene Frequency; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D005838:Genotype; D008297:Male; D008460:Meat / Q000592:standards*; D018482:Muscle, Skeletal / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D050151:Subcutaneous Fat / Q000033:anatomy & histology
chemical_list: D005819:Genetic Markers