title: Tanshinone IIA inhibits angiotensin II induced extracellular matrix remodeling in human cardiac fibroblasts--Implications for treatment of pathologic cardiac remodeling.
authors.affiliation: Department of Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China; Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Physiology & Experimental Medicine, Hospital for Sick Children, Toronto M5G 0A4, Canada.
authors.forename: Shuai
authors.initials: S
authors.lastname: Mao
authors.affiliation: Faculty of Medicine, University of Toronto, University Ave. Toronto M5G 0A4, Canada.
authors.forename: Winny
authors.initials: W
authors.lastname: Li
authors.affiliation: Physiology & Experimental Medicine, Hospital for Sick Children, Toronto M5G 0A4, Canada.
authors.forename: Nour
authors.initials: N
authors.lastname: Qa'aty
authors.affiliation: Physiology & Experimental Medicine, Hospital for Sick Children, Toronto M5G 0A4, Canada.
authors.forename: Mattchew
authors.initials: M
authors.lastname: Vincent
authors.affiliation: Department of Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China; Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. Electronic address: minzhouzhang@yeah.net.
authors.forename: Minzhou
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Physiology & Experimental Medicine, Hospital for Sick Children, Toronto M5G 0A4, Canada.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Hinek
mesh_terms: D045784:Abietanes / Q000494:pharmacology*; D000804:Angiotensin II / Q000633:toxicity*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005109:Extracellular Matrix / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D016896:Treatment Outcome; D020257:Ventricular Remodeling / Q000187:drug effects* / Q000502:physiology
chemical_list: D045784:Abietanes; C021751:tanshinone; D000804:Angiotensin II