title: [Study on solid dispersion of precipitated calcium carbonate-based oleanolic acid].
abstract: Oleanolic acid-precipitated calcium carbonate solid dispersion was prepared by using solvent evaporation method. The microscopic structure and physicochemical properties of solid dispersion were analyzed using differential scanning calorimetry and scanning electron microscopy (SEM). And its in vitro release also was investigated. The properties of the precipitated calcium carbonate was studied which was as a carrier of oleanolic acid solid dispersion. Differential scanning calorimetry analysis suggested that oleanolic acid may be present in solid dispersion as amorphous substance. The in vitro release determination results of oleanolic acid-precipitated calcium carbonate (1: 5) solid dispersion showed accumulated dissolution rate of.oleanolic acid was up to 90% at 45 min. Accelerating experiment showed that content and in vitro dissolution of oleanolic acid solid dispersion did not change after storing over 6 months. The results indicated that in vitro dissolution of oleanolic acid was improved greatly by the solid dispersion with precipitated calcium carbonate as a carrier. The solid dispersion is a stabilizing system which has actual applied value.
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Yan
authors.forename: Zhen-hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Xiao-bin
authors.initials: XB
authors.lastname: Jia
authors.forename: Yan-rong
authors.initials: YR
authors.lastname: Jiang
authors.forename: E
authors.initials: E
authors.lastname: Sun
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D008855:Microscopy, Electron, Scanning; D009828:Oleanolic Acid / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D012995:Solubility
chemical_list: D004337:Drug Carriers; D010936:Plant Extracts; D009828:Oleanolic Acid; D002119:Calcium Carbonate