title: Clinical translation of a high-performance neural prosthesis.
abstract: Neural prostheses have the potential to improve the quality of life of individuals with paralysis by directly mapping neural activity to limb- and computer-control signals. We translated a neural prosthetic system previously developed in animal model studies for use by two individuals with amyotrophic lateral sclerosis who had intracortical microelectrode arrays placed in motor cortex. Measured more than 1 year after implant, the neural cursor-control system showed the highest published performance achieved by a person to date, more than double that of previous pilot clinical trial participants.
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, California, USA.|Department of Electrical Engineering, Stanford University, Stanford, California, USA.|School of Engineering, Brown University, Providence, Rhode Island, USA.|Department of Electrical and Computer Engineering, University of CaliforniaSan Diego, La Jolla, California, USA.
authors.forename: Vikash
authors.initials: V
authors.lastname: Gilja
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, California, USA.|Department of Electrical Engineering, Stanford University, Stanford, California, USA.|Stanford Neurosciences Institute, Stanford University, Stanford, California, USA.
authors.forename: Chethan
authors.identifier: http://orcid.org/0000-0003-1241-1432
authors.initials: C
authors.lastname: Pandarinath
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, California, USA.
authors.forename: Christine H
authors.initials: CH
authors.lastname: Blabe
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, California, USA.|Department of Electrical Engineering, Stanford University, Stanford, California, USA.|Stanford Neurosciences Institute, Stanford University, Stanford, California, USA.
authors.forename: Paul
authors.identifier: http://orcid.org/0000-0001-7778-5473
authors.initials: P
authors.lastname: Nuyujukian
authors.affiliation: School of Engineering, Brown University, Providence, Rhode Island, USA.|Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, Rhode Island, USA.|Brown Institute for Brain Science, Brown University, Providence, Rhode Island, USA.|Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Simeral
authors.affiliation: School of Engineering, Brown University, Providence, Rhode Island, USA.|Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, Rhode Island, USA.|Brown Institute for Brain Science, Brown University, Providence, Rhode Island, USA.|Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Anish A
authors.initials: AA
authors.lastname: Sarma
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Brittany L
authors.initials: BL
authors.lastname: Sorice
authors.affiliation: School of Engineering, Brown University, Providence, Rhode Island, USA.|Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, Rhode Island, USA.|Brown Institute for Brain Science, Brown University, Providence, Rhode Island, USA.
authors.forename: János A
authors.initials: JA
authors.lastname: Perge
authors.affiliation: Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, Rhode Island, USA.|Brown Institute for Brain Science, Brown University, Providence, Rhode Island, USA.|Department of Neuroscience, Brown University, Providence, Rhode Island, USA.
authors.forename: Beata
authors.initials: B
authors.lastname: Jarosiewicz
authors.affiliation: School of Engineering, Brown University, Providence, Rhode Island, USA.|Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, Rhode Island, USA.|Brown Institute for Brain Science, Brown University, Providence, Rhode Island, USA.|Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.|Neurology, Harvard Medical School, Boston,Massachusetts, USA.
authors.forename: Leigh R
authors.initials: LR
authors.lastname: Hochberg
authors.affiliation: Department of Electrical Engineering, Stanford University, Stanford, California, USA.|Stanford Neurosciences Institute, Stanford University, Stanford, California, USA.|Department of Neurobiology, Stanford University, Stanford, California, USA.|Department of Bioengineering, Stanford University, Stanford, California, USA.|Howard Hughes Medical Institute, Stanford University, Stanford, California, USA.
authors.forename: Krishna V
authors.initials: KV
authors.lastname: Shenoy
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, California, USA.|Stanford Neurosciences Institute, Stanford University, Stanford, California, USA.
authors.forename: Jaimie M
authors.initials: JM
authors.lastname: Henderson
mesh_terms: D006801:Humans; D008839:Microelectrodes; D058117:Neural Prostheses; D010243:Paralysis / Q000628:therapy*; D011788:Quality of Life; D057170:Translational Research, Biomedical