title: Absorption and initial metabolism of 75Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data.
abstract: Selenomethionine (SeMet) is an important organic nutritional source of Se, but the uptake and metabolism of SeMet are poorly characterised in humans. Dynamic gamma camera images of the abdominal region were acquired from eight healthy young men after the ingestion of radioactive 75Se-l-SeMet (75Se-SeMet). Scanning started simultaneously to the ingestion of 75Se-SeMet and lasted 120 min. We generated time-activity curves from two-dimensional regions of interest in the stomach, small intestine and liver. During scanning, blood samples were collected at 10-min intervals to generate plasma time-activity curves. A four-compartment model, augmented with a delay between the liver and plasma, was fitted to individual participants' data. The mean rate constant for 75Se-SeMet transport was 2·63 h-1 from the stomach to the small intestine, 13·2 h-1 from the small intestine to the liver, 0·261 h-1 from the liver to the plasma and 0·267 h-1 from the stomach to the plasma. The delay in the liver was 0·714 h. Gamma camera imaging provides data for use in compartmental modelling of 75Se-SeMet absorption and metabolism in humans. In clinical settings, the obtained rate constants and the delay in the liver may be useful variables for quantifying reduced intestinal absorption capacity or liver function.
authors.affiliation: 1Department of Mathematical Sciences,Laboratory of Applied Statistics,University of Copenhagen,DK-2100 Copenhagen Ø,Denmark.
authors.forename: Mareile
authors.initials: M
authors.lastname: Große Ruse
authors.affiliation: 2Department of Clinical Physiology and Nuclear Medicine,Centre of Functional Imaging and Research,Hvidovre Hospital,DK-2650 Hvidovre,Denmark.
authors.forename: Lasse R
authors.initials: LR
authors.lastname: Søndergaard
authors.affiliation: 1Department of Mathematical Sciences,Laboratory of Applied Statistics,University of Copenhagen,DK-2100 Copenhagen Ø,Denmark.
authors.forename: Susanne
authors.initials: S
authors.lastname: Ditlevsen
authors.affiliation: 2Department of Clinical Physiology and Nuclear Medicine,Centre of Functional Imaging and Research,Hvidovre Hospital,DK-2650 Hvidovre,Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: Damgaard
authors.affiliation: 2Department of Clinical Physiology and Nuclear Medicine,Centre of Functional Imaging and Research,Hvidovre Hospital,DK-2650 Hvidovre,Denmark.
authors.forename: Stefan
authors.initials: S
authors.lastname: Fuglsang
authors.affiliation: 3Department of Science,Systems and Models,Roskilde University,DK-4000 Roskilde,Denmark.
authors.forename: Johnny T
authors.initials: JT
authors.lastname: Ottesen
authors.affiliation: 2Department of Clinical Physiology and Nuclear Medicine,Centre of Functional Imaging and Research,Hvidovre Hospital,DK-2650 Hvidovre,Denmark.
authors.forename: Jan L
authors.initials: JL
authors.lastname: Madsen
mesh_terms: D000818:Animals; D015902:Gamma Cameras; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D008962:Models, Theoretical; D011877:Radionuclide Imaging; D012644:Selenium Radioisotopes; D012645:Selenomethionine / Q000097:blood / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D012644:Selenium Radioisotopes; D012645:Selenomethionine
keywords: 75-l-SeMet 
                    75Se-SeMet; 75Se-l-selenomethionine; Absorption capacity; Compartmental modelling; Gamma camera imaging; Metabolism; ROI region of interest; SeMet selenomethionine; Selenomethionine