title: Role of Special Coagulation Studies for Preoperative Screening of Thrombotic Complications in Simultaneous Pancreas-Kidney Transplantation.
abstract: BACKGROUND
  Vascular thrombosis is a well-known complication after simultaneous pancreas-kidney (SPK) transplantation procedures. The role of preoperative special coagulation studies to screen patients at high risk for vascular thrombosis is unclear and not well studied.
  
  
  METHODS
  This study reports a retrospective medical record review of 83 SPK procedures performed between April 2007 and June 2013 in a single institution. All SPK transplantation recipients underwent preoperative screening for hypercoagulable state.
  
  
  RESULTS
  Eighteen of 83 patients (21.69%) were diagnosed with vascular thrombosis of the pancreas. Of the 23 patients with at least 1 positive screening test, only 4 had a thrombotic event (17.39%). On the other hand, 14 of 60 patients with negative screening tests developed vascular thrombosis (23.33%). The hypercoagulable screening workup had a positive predictive value of 17.39% and a negative predictive value of 76.67%. The workup also demonstrated low sensitivity (22.22%) and specificity (70.77%).
  
  
  CONCLUSIONS
  No differences were seen in patient or graft survival between groups at 12 months. This retrospective study did not show any benefit of using special coagulation studies to rule out patients at risk for vascular thrombosis after SPK transplantation.
authors.affiliation: Department of Nephrology, Ochsner Clinic Foundation, New Orleans, LA ; Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
authors.forename: Abdul
authors.initials: A
authors.lastname: Moiz
authors.affiliation: Department of Nephrology, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Tariq
authors.initials: T
authors.lastname: Javed
authors.affiliation: Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
authors.forename: Humberto
authors.initials: H
authors.lastname: Bohorquez
authors.affiliation: Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
authors.forename: David S
authors.initials: DS
authors.lastname: Bruce
authors.affiliation: Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
authors.forename: Ian C
authors.initials: IC
authors.lastname: Carmody
authors.affiliation: Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
authors.forename: Ari J
authors.initials: AJ
authors.lastname: Cohen
authors.affiliation: Department of Nephrology, Ochsner Clinic Foundation, New Orleans, LA ; Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Staffeld-Coit
authors.affiliation: Office of Biostatistical Support, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
authors.forename: George E
authors.initials: GE
authors.lastname: Loss
authors.affiliation: Department of Nephrology, Ochsner Clinic Foundation, New Orleans, LA ; Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Jorge
authors.initials: J
authors.lastname: Garces
keywords: Blood coagulation tests; kidney transplantation; mesenteric ischemia; organ transplantation; pancreas transplantation; thrombosis