title: The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease.
abstract: The endocannabinoid system (ECS) functions to adjust behavior and metabolism according to environmental changes in food availability. Its actions range from the regulation of sensory responses to the development of preference for the consumption of calorically-rich food and control of its metabolic handling. ECS activity is beneficial when access to food is scarce or unpredictable. However, when food is plentiful, the ECS favors obesity and metabolic disease. We review recent advances in understanding the roles of the ECS in energy balance, and discuss newly identified mechanisms of action that, after the withdrawal of first generation cannabinoid type 1 (CB1) receptor antagonists for the treatment of obesity, have made the ECS once again an attractive target for therapy.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France; University of Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France.
authors.forename: Wilfrid
authors.initials: W
authors.lastname: Mazier
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France; University of Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Saucisse
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France; University of Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France; Endocrinology Department, Haut-Lévêque Hospital, 33604 Pessac, France.
authors.forename: Blandine
authors.initials: B
authors.lastname: Gatta-Cherifi
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France; University of Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Unité 862, 33000 Bordeaux, France. Electronic address: daniela.cota@inserm.fr.
authors.forename: Daniela
authors.initials: D
authors.lastname: Cota
mesh_terms: D000818:Animals; D004435:Eating / Q000502:physiology; D063388:Endocannabinoids / Q000378:metabolism*; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*
chemical_list: D063388:Endocannabinoids
keywords: CB(1); Endocannabinoids; energy balance; food intake; metabolism; obesity