title: Intra-Arterial Administration of Multipotent Mesenchymal Stromal Cells Promotes Functional Recovery of the Brain After Traumatic Brain Injury.
abstract: We compared the efficiency of delivery of multipotent mesenchymal stem cells into the brain after their intravenous and intra-arterial injection. Analysis of the therapeutic effects of cells after experimental traumatic brain injury revealed improvement of the neurological status and motor functions of the damaged hemisphere, the effect being more pronounced after intraarterial injection of cells. Intra-arterial administration was followed by rapid infiltration of the cells into the brain tissue and their number considerably surpassed that after intravenous infusion. Targeted delivery of multipotent mesenchymal stromal cells into the brain after their injection into the carotid arteries substantially potentiated their neuroprotective effects in traumatic brain injury.
authors.affiliation: A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia.
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.affiliation: A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Plotnikov
authors.affiliation: Faculty and Bioengineering and Bioinformatics, Moscow, Russia.|V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Babenko
authors.affiliation: Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: T I
authors.initials: TI
authors.lastname: Danilina
authors.affiliation: International Laser Research Center, Moscow, Russia. zorov@genebee.msu.ru.
authors.forename: L D
authors.initials: LD
authors.lastname: Zorov
authors.affiliation: A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Pevzner
authors.affiliation: A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia.
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy*; D002465:Cell Movement; D002478:Cells, Cultured; D007269:Injections, Intra-Arterial; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology; D051381:Rats; D020127:Recovery of Function
keywords: migration; sensorimotor deficit; stem cells; traumatic brain injury