title: Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function.
abstract: Pregnancy needs complex pathways that together play a role in proper growth and protection of the fetus preventing its premature loss. Changes during pregnancy and postpartum period include the manifold machinery of neuroactive steroids that plays a crucial role in neuronal excitability by local modulation of specific inhibitory receptors: the GABAA receptors. Marked fluctuations in both blood and brain concentration of neuroactive steroids strongly contribute to GABAA receptor function and plasticity. In this review, we listed several interesting results regarding the regulation and plasticity of GABAA receptor function during pregnancy and postpartum period in rats. The increase in brain levels of neuroactive steroids during pregnancy and their sudden decrease immediately before delivery are causally related to changes in the expression/function of specific GABAA receptor subunits in the hippocampus. These data suggest that alterations in GABAA receptor expression and function may be related to neurological and psychiatric disorders associated with crucial periods in women. These findings could help to provide potential new treatments for these women's disabling syndromes.
authors.affiliation: Department of Life and Environmental Sciences, University of Cagliari, 09126 Cagliari, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Licheri
authors.affiliation: Institute of Neuroscience, National Research Council, Monserrato, 09042 Cagliari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Talani
authors.affiliation: Department of Life and Environmental Sciences, University of Cagliari, 09126 Cagliari, Italy.
authors.forename: Ashish A
authors.initials: AA
authors.lastname: Gorule
authors.affiliation: Institute of Neuroscience, National Research Council, Monserrato, 09042 Cagliari, Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Mostallino
authors.affiliation: Department of Life and Environmental Sciences, University of Cagliari, 09126 Cagliari, Italy ; Institute of Neuroscience, National Research Council, Monserrato, 09042 Cagliari, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Biggio
authors.affiliation: Department of Life and Environmental Sciences, University of Cagliari, 09126 Cagliari, Italy ; Institute of Neuroscience, National Research Council, Monserrato, 09042 Cagliari, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Sanna
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D009473:Neuronal Plasticity / Q000235:genetics* / Q000502:physiology*; D049590:Postpartum Period / Q000235:genetics* / Q000502:physiology*; D011247:Pregnancy; D011963:Receptors, GABA-A / Q000235:genetics* / Q000502:physiology*
chemical_list: D011963:Receptors, GABA-A