title: Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
abstract: Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors.forename: Felix R
authors.initials: FR
authors.lastname: Day
authors.affiliation: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Ruth
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Thompson
authors.affiliation: Boston University School of Public Health, Department of Biostatistics. Boston, Massachusetts 02118, USA.|NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Lunetta
authors.affiliation: Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.|Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Pervjakova
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.|Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Chasman
authors.affiliation: Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands.|Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.
authors.forename: Lisette
authors.initials: L
authors.lastname: Stolk
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.|Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA.
authors.forename: Hilary K
authors.initials: HK
authors.lastname: Finucane
authors.affiliation: deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland.
authors.forename: Patrick
authors.initials: P
authors.lastname: Sulem
authors.affiliation: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.|Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, US.
authors.forename: Brendan
authors.initials: B
authors.lastname: Bulik-Sullivan
authors.affiliation: Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.|Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.|Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.|Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.
authors.forename: Tõnu
authors.initials: T
authors.lastname: Esko
authors.affiliation: NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Johnson
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors.forename: Cathy E
authors.initials: CE
authors.lastname: Elks
authors.affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Nora
authors.initials: N
authors.lastname: Franceschini
authors.affiliation: Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA.|Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
authors.forename: Chunyan
authors.initials: C
authors.lastname: He
authors.affiliation: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Altmaier
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle Washington 98101 USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Brody
authors.affiliation: Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
authors.forename: Lude L
authors.initials: LL
authors.lastname: Franke
authors.affiliation: NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.|Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Huffman
authors.affiliation: Merck Pharmaceuticals, 33 Avenue Louis Pasteur, Boston, MA 02115, United States.
authors.forename: Margaux F
authors.initials: MF
authors.lastname: Keller
authors.affiliation: Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201.
authors.forename: Patrick F
authors.initials: PF
authors.lastname: McArdle
authors.affiliation: Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Nutile
authors.affiliation: Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.|University of Sassari, Department of Biomedical Sciences, Sassari, 07100 Sassari, Italy.|Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Porcu
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
authors.forename: Antonietta
authors.initials: A
authors.lastname: Robino
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.
authors.forename: Lynda M
authors.initials: LM
authors.lastname: Rose
authors.affiliation: Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.
authors.forename: Ursula M
authors.initials: UM
authors.lastname: Schick
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Smith
authors.affiliation: Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Teumer
authors.affiliation: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Traglia
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.|Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
authors.forename: Dragana
authors.initials: D
authors.lastname: Vuckovic
authors.affiliation: The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Albrecht
authors.affiliation: Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
authors.forename: Najaf
authors.initials: N
authors.lastname: Amin
authors.affiliation: Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland.|Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland.
authors.forename: Tanguy
authors.initials: T
authors.lastname: Corre
authors.affiliation: Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
authors.forename: Jouke-Jan
authors.initials: JJ
authors.lastname: Hottenga
authors.affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.|National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK.
authors.forename: Massimo
authors.initials: M
authors.lastname: Mangino
authors.affiliation: Icelandic Heart Association, Kopavogur, Iceland.|Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
authors.forename: Albert V
authors.initials: AV
authors.lastname: Smith
authors.affiliation: Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, United States of America.
authors.forename: Toshiko
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA.
authors.forename: Goncalo
authors.initials: G
authors.lastname: Abecasis
authors.affiliation: Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.|Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Irene L
authors.initials: IL
authors.lastname: Andrulis
authors.affiliation: Department of Epidemiology, University of California Irvine, Irvine, California, USA.
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
authors.forename: Antonis C
authors.initials: AC
authors.lastname: Antoniou
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Arndt
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors.forename: Alice M
authors.initials: AM
authors.lastname: Arnold
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.|Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Barbieri
authors.affiliation: Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Beckmann
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Alicia
authors.initials: A
authors.lastname: Beeghly-Fadiel
authors.affiliation: Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.|Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Benitez
authors.affiliation: Beckman Research Institute of City of Hope, Duarte, CA, USA.
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Suzette J
authors.initials: SJ
authors.lastname: Bielinski
authors.affiliation: Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Carl
authors.initials: C
authors.lastname: Blomqvist
authors.affiliation: Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.|Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.affiliation: Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Bogdanova
authors.affiliation: Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.|Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Stig E
authors.initials: SE
authors.lastname: Bojesen
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
authors.forename: Manjeet K
authors.initials: MK
authors.lastname: Bolla
authors.affiliation: Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Borresen-Dale
authors.affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
authors.forename: Thibaud S
authors.initials: TS
authors.lastname: Boutin
authors.affiliation: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.|University of Tübingen, Tübingen, Germany.|German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Hiltrud
authors.initials: H
authors.lastname: Brauch
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.|German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.|Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Hermann
authors.initials: H
authors.lastname: Brenner
authors.affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brüning
authors.affiliation: Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.|Molecular Biology of Breast Cancer, Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
authors.affiliation: Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
authors.forename: Archie
authors.initials: A
authors.lastname: Campbell
authors.affiliation: Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
authors.forename: Harry
authors.initials: H
authors.lastname: Campbell
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
authors.forename: J Ross
authors.initials: JR
authors.lastname: Chapman
authors.affiliation: The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Yii-Der Ida
authors.initials: YI
authors.lastname: Chen
authors.affiliation: Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Fergus J
authors.initials: FJ
authors.lastname: Couch
authors.affiliation: Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA.
authors.forename: Andrea D
authors.initials: AD
authors.lastname: Coviello
authors.affiliation: Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK.
authors.forename: Angela
authors.initials: A
authors.lastname: Cox
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
authors.forename: Kamila
authors.initials: K
authors.lastname: Czene
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
authors.forename: Hatef
authors.initials: H
authors.lastname: Darabi
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Immaculata
authors.initials: I
authors.lastname: De Vivo
authors.affiliation: Division of Epidemiology & Community Health, University of Minnesotta, Minneapolis MN 55455.
authors.forename: Ellen W
authors.initials: EW
authors.lastname: Demerath
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
authors.forename: Joe
authors.initials: J
authors.lastname: Dennis
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.|Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Devilee
authors.affiliation: Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
authors.forename: Thilo
authors.initials: T
authors.lastname: Dörk
authors.affiliation: Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Isabel
authors.initials: I
authors.lastname: Dos-Santos-Silva
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Dunning
authors.affiliation: NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Eicher
authors.affiliation: Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.|David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Fasching
authors.affiliation: Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Jessica D
authors.initials: JD
authors.lastname: Faul
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
authors.forename: Jonine
authors.initials: J
authors.lastname: Figueroa
authors.affiliation: Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany.|Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Flesch-Janys
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.|Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Gandin
authors.affiliation: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
authors.forename: Melissa E
authors.initials: ME
authors.lastname: Garcia
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.|Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
authors.forename: Montserrat
authors.initials: M
authors.lastname: García-Closas
authors.affiliation: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.|Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.affiliation: Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
authors.forename: Giorgia G
authors.initials: GG
authors.lastname: Girotto
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada.|Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Canada.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Goldberg
authors.affiliation: Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: González-Neira
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Mark O
authors.initials: MO
authors.lastname: Goodarzi
authors.affiliation: Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
authors.forename: Megan L
authors.initials: ML
authors.lastname: Grove
authors.affiliation: deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland.|School of Engineering and Natural Sciences, University of Iceland, IS-101 Reykjavik, Iceland.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Gudbjartsson
authors.affiliation: Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France.|University Paris-Sud, UMRS 1018, Villejuif, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Guénel
authors.affiliation: The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Hall
authors.affiliation: Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
authors.forename: Ute
authors.initials: U
authors.lastname: Hamann
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.affiliation: Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen AB25 2ZD, UK.
authors.forename: Lynne J
authors.initials: LJ
authors.lastname: Hocking
authors.affiliation: Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Homuth
authors.affiliation: Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Maartje J
authors.initials: MJ
authors.lastname: Hooning
authors.affiliation: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.|Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Medical Genomics,Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Jinyan
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
authors.forename: Keith
authors.initials: K
authors.lastname: Humphreys
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.|Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.|Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.affiliation: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
authors.forename: Samuel E
authors.initials: SE
authors.lastname: Jones
authors.affiliation: Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Kabisch
authors.affiliation: Harvard Medical School, Boston, MA 02115, USA.|Hebrew SeniorLife Institute for Aging Research, Boston, MA, 02131, USA.
authors.forename: David
authors.initials: D
authors.lastname: Karasik
authors.affiliation: Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.|Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Knight
authors.affiliation: Faculty of Medicine, University of Split, Split, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Kolcic
authors.affiliation: Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Kooperberg
authors.affiliation: Cancer Center, Kuopio University Hospital, Kuopio, Finland.|School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.|Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Veli-Matti
authors.initials: VM
authors.lastname: Kosma
authors.affiliation: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.|German Center for Diabetes Research, 85764 Neuherberg, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kriebel
authors.affiliation: Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.|Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway.
authors.forename: Vessela
authors.initials: V
authors.lastname: Kristensen
authors.affiliation: Vesalius Research Center (VRC), VIB, Leuven, Belgium.|Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
authors.forename: Diether
authors.initials: D
authors.lastname: Lambrechts
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors.forename: Claudia
authors.initials: C
authors.lastname: Langenberg
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
authors.forename: Jingmei
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Lindström
authors.affiliation: Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Liu
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors.forename: Jian'an
authors.initials: J
authors.lastname: Luan
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.affiliation: Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
authors.forename: Reedik
authors.initials: R
authors.lastname: Mägi
authors.affiliation: Cancer Center, Kuopio University Hospital, Kuopio, Finland.|School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.|Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Arto
authors.initials: A
authors.lastname: Mannermaa
authors.affiliation: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Manz
authors.affiliation: Department of Oncology - Pathology, Karolinska Institutet, Stockholm 17177, Sweden.
authors.forename: Sara
authors.initials: S
authors.lastname: Margolin
authors.affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Marten
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.affiliation: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Masciullo
authors.affiliation: Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
authors.forename: Alfons
authors.initials: A
authors.lastname: Meindl
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Michailidou
authors.affiliation: Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
authors.forename: Evelin
authors.initials: E
authors.lastname: Mihailov
authors.affiliation: Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
authors.forename: Lili
authors.initials: L
authors.lastname: Milani
authors.affiliation: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.|Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Milne
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Department of Medicine I, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.|DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Müller-Nurasyid
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Nalls
authors.affiliation: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.|Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.|Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, US.
authors.forename: Ben M
authors.initials: BM
authors.lastname: Neale
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Heli
authors.initials: H
authors.lastname: Nevanlinna
authors.affiliation: KULeuven (University of Leuven), Department of Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Belgium.
authors.forename: Patrick
authors.initials: P
authors.lastname: Neven
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.affiliation: Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.|Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Børge G
authors.initials: BG
authors.lastname: Nordestgaard
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Janet E
authors.initials: JE
authors.lastname: Olson
authors.affiliation: British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
authors.forename: Sandosh
authors.initials: S
authors.lastname: Padmanabhan
authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Peterlongo
authors.affiliation: Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Peters
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Petersmann
authors.affiliation: Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Julian
authors.initials: J
authors.lastname: Peto
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.|Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Paul D P
authors.initials: PDP
authors.lastname: Pharoah
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.|Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
authors.forename: Nicola N
authors.initials: NN
authors.lastname: Pirastu
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
authors.forename: Ailith
authors.initials: A
authors.lastname: Pirie
authors.affiliation: Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.|University of Sassari, Department of Biomedical Sciences, Sassari, 07100 Sassari, Italy.|Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Pistis
authors.affiliation: Faculty of Medicine, University of Split, Split, Croatia.
authors.forename: Ozren
authors.initials: O
authors.lastname: Polasek
authors.affiliation: Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
authors.forename: David
authors.initials: D
authors.lastname: Porteous
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle Washington 98101 USA.|Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA.|Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA.|Department of Health Services, University of Washington, Seattle, Washington 98101, USA.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.affiliation: Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu, Finland.|Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland.
authors.forename: Katri
authors.initials: K
authors.lastname: Pylkäs
authors.affiliation: Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Radice
authors.affiliation: Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.|UCLA Clinical & Translational Science Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Leslie J
authors.initials: LJ
authors.lastname: Raffel
authors.affiliation: Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands.|Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.|Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivadeneira
authors.affiliation: Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
authors.forename: Igor
authors.initials: I
authors.lastname: Rudan
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Rudolph
authors.affiliation: Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Ruggiero
authors.affiliation: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
authors.forename: Cinzia F
authors.initials: CF
authors.lastname: Sala
authors.affiliation: Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Sanna
authors.affiliation: Research Oncology, Guy's Hospital, King's College London, London, UK.
authors.forename: Elinor J
authors.initials: EJ
authors.lastname: Sawyer
authors.affiliation: National Institute on Aging, Intramural Research Program, Baltimore, MD 20892, USA.
authors.forename: David
authors.initials: D
authors.lastname: Schlessinger
authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
authors.forename: Marjanka K
authors.initials: MK
authors.lastname: Schmidt
authors.affiliation: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Schmidt
authors.affiliation: Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany.|Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.|Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany.
authors.forename: Rita K
authors.initials: RK
authors.lastname: Schmutzler
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
authors.forename: Minouk J
authors.initials: MJ
authors.lastname: Schoemaker
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Scott
authors.affiliation: Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Seynaeve
authors.affiliation: Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Simard
authors.affiliation: Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Sorice
authors.affiliation: Department of Pathology, The University of Melbourne, Melbourne, Australia.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
authors.forename: Doris
authors.initials: D
authors.lastname: Stöckl
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Strauch
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.|Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
authors.forename: Anthony
authors.initials: A
authors.lastname: Swerdlow
authors.affiliation: The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Kent D
authors.initials: KD
authors.lastname: Taylor
authors.affiliation: deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland.|Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Toland
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.|NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE Oxford, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Tomlinson
authors.affiliation: Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France.|University Paris-Sud, UMRS 1018, Villejuif, France.
authors.forename: Thérèse
authors.initials: T
authors.lastname: Truong
authors.affiliation: Icelandic Cancer Registry, Reykjavik, Iceland.
authors.forename: Laufey
authors.initials: L
authors.lastname: Tryggvadottir
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Turner
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Vozzi
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, 37203, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Wellons
authors.affiliation: Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
authors.forename: Gonneke
authors.initials: G
authors.lastname: Willemsen
authors.affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.|Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
authors.forename: James F
authors.initials: JF
authors.lastname: Wilson
authors.affiliation: Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu, Finland.|Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland.
authors.forename: Robert
authors.initials: R
authors.lastname: Winqvist
authors.affiliation: Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.|LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Bruce B H R
authors.initials: BBHR
authors.lastname: Wolffenbuttel
authors.affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
authors.forename: Alan F
authors.initials: AF
authors.lastname: Wright
authors.affiliation: Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece.
authors.forename: Drakoulis
authors.initials: D
authors.lastname: Yannoukakos
authors.affiliation: Faculty of Medicine, University of Split, Split, Croatia.
authors.forename: Tatijana
authors.initials: T
authors.lastname: Zemunik
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Obstetrics and Gynecology, University Medicine Greifswald, 17475 Greifswald, Germany.
authors.forename: Marek
authors.initials: M
authors.lastname: Zygmunt
authors.affiliation: Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland.|Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland.
authors.forename: Sven
authors.initials: S
authors.lastname: Bergmann
authors.affiliation: Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.|Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Julie E
authors.initials: JE
authors.lastname: Buring
authors.affiliation: Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, United States of America.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: Grant W
authors.initials: GW
authors.lastname: Montgomery
authors.affiliation: Icelandic Heart Association, Kopavogur, Iceland.|Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
authors.forename: Tim D
authors.initials: TD
authors.lastname: Spector
authors.affiliation: Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.affiliation: Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Behrooz Z
authors.initials: BZ
authors.lastname: Alizadeh
authors.affiliation: Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Ciullo
authors.affiliation: Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Crisponi
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.|Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.|Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
authors.forename: Paolo P
authors.initials: PP
authors.lastname: Gasparini
authors.affiliation: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Gieger
authors.affiliation: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
authors.forename: Caroline
authors.initials: C
authors.lastname: Hayward
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Sharon L R
authors.initials: SLR
authors.lastname: Kardia
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.|Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: McKnight
authors.affiliation: Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
authors.forename: Andres
authors.initials: A
authors.lastname: Metspalu
authors.affiliation: Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
authors.forename: Alanna C
authors.initials: AC
authors.lastname: Morrison
authors.affiliation: Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.|Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA.
authors.forename: Alex P
authors.initials: AP
authors.lastname: Reiner
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.|Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Ridker
authors.affiliation: The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Toniolo
authors.affiliation: Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands.|Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.|Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.affiliation: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
authors.forename: Sheila
authors.initials: S
authors.lastname: Ulivi
authors.affiliation: Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.affiliation: Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Weir
authors.affiliation: Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Yerges-Armstrong
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Alkes L
authors.initials: AL
authors.lastname: Price
authors.affiliation: deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland.|Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
authors.affiliation: Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands.
authors.forename: Jenny A
authors.initials: JA
authors.lastname: Visser
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.|Department of Paediatrics,University of Cambridge,Cambridge, CB2 0QQ, UK.
authors.forename: Ken K
authors.initials: KK
authors.lastname: Ong
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Jenny
authors.initials: J
authors.lastname: Chang-Claude
authors.affiliation: NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.|Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Murabito
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors.forename: John R B
authors.initials: JRB
authors.lastname: Perry
authors.affiliation: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Murray
mesh_terms: D000328:Adult; D000367:Age Factors; D000375:Aging / Q000235:genetics; D019313:BRCA1 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D004260:DNA Repair; D005260:Female; D053263:Gene Regulatory Networks / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D055106:Genome-Wide Association Study / Q000379:methods; D023281:Genomics / Q000379:methods; D005838:Genotype; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D008593:Menopause / Q000235:genetics; D008875:Middle Aged; D008957:Models, Genetic; D010641:Phenotype; D012098:Reproduction / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D019313:BRCA1 Protein