title: Anti-fungal activities of medicinal plants extracts of Ivorian pharmacopoeia.
abstract: OBJECTIVE
  This study was to evaluate in vitro anti-fungal activity of aqueous and hydroethanolic from medicinal plants extracts collected in Côte d'Ivoire.
  
  
  METHODS
  Plants extracts were prepared by homogenization and separately incorporated to Sabouraud agar using the agar slanted double dilution method. Ketoconazole was used as standards for anti-fungal assay. The anti-fungal tests were performed by sowing 1000 cells of Candida albicans on the previously prepared medium culture. Anti-fungal activity was determined by evaluating anti-fungal parameters values (minimal fungicidal concentrations [MFC] and IC50).
  
  
  RESULTS
  The results showed that all extracts possessed anti-fungal activities whose levels vary from plant species to another. Eight of them had a satisfactory anti-candidosic activity and extracts from Terminalia species were the most active. Among them the Terminalia superba extracts generated the strongest activities (MFC = 0.0975 mg/mL). Compared with ketoconazole (MFC = 0.390 mg/mL), the T. superba extracts, aqueous (MFC = 0.195 mg/mL) and hydroethanolic (0.0975 mg/mL) were successively twice and four times more active. The worst anti-fungal activity (MFC = 1600 mg/mL) was obtained with the Guarea cedrata aqueous extract.
  
  
  CONCLUSIONS
  All medicinal plants extracts produced anti-fungal activities, and T. superba was the most active.
authors.affiliation: Department of Biochemistry, Laboratory of Pharmacodynamy Biochemistry, UFR of Biosciences, Université Felix Houphouët-Boigny, Abidjan, Côte d'Ivoire.
authors.forename: Kra Adou Koffi
authors.initials: KA
authors.lastname: Mathieu
authors.affiliation: Department of Biochemistry, Laboratory of Pharmacodynamy Biochemistry, UFR of Biosciences, Université Felix Houphouët-Boigny, Abidjan, Côte d'Ivoire.
authors.forename: Ahon Gnamien
authors.initials: AG
authors.lastname: Marcel
authors.affiliation: International Language Office, Abidjan, Côte d'Ivoire.
authors.forename: Djo-Bi
authors.initials: DB
authors.lastname: Djè
authors.affiliation: Department of Biochemistry, Laboratory of Pharmacodynamy Biochemistry, UFR of Biosciences, Université Felix Houphouët-Boigny, Abidjan, Côte d'Ivoire.
authors.forename: Ouattara
authors.initials: O
authors.lastname: Sitapha
authors.affiliation: Department of Biochemistry, Laboratory of Pharmacodynamy Biochemistry, Université Péléforo Gon Coulibaly, Korhogo, Côte d'Ivoire.
authors.forename: Coulibaly
authors.initials: C
authors.lastname: Adama
authors.affiliation: Department of Clinical and Fundamental Biochemistry, Pasteur Institute, Abidjan, Côte d'Ivoire.
authors.forename: Djaman Allico
authors.initials: DA
authors.lastname: Joseph
keywords: Anti-candidosic; anti-fungal; ketoconazole; plant extracts