title: Lesional accumulation of CD8(+) cells in sciatic nerves of experimental autoimmune neuritis rats.
abstract: Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies. Macrophages are the major immune cells in peripheral nerves and may exert tissue-damage or tissue-protective activity during EAN. While considered to define a subpopulation of T lymphocytes, CD8 expression has been found on certain macrophages that show cytotoxic effects. Here we have studied the spatiotemporal accumulation of CD8(+) cells in sciatic nerves of EAN rats. A robust accumulation of CD8(+) cells was observed in the sciatic nerves of EAN rats, which was positively correlated with the severity of neurological signs in EAN. Moreover, double-labelling experiments showed that the major cellular sources of CD8 were reactive macrophages. Therefore, our data here suggest a pathological role of CD8(+) macrophages in EAN, which makes CD8(+) macrophage a potential therapeutic target for EAN.
authors.affiliation: Department of Medicine, Shunde Polytechnic, Desheng East Street, Foshan, 528300, China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Zhang
authors.affiliation: Institute of Immunology, Third Military Medical University of PLA, Gaotanyan Street 30, Chongqing, 400038, China.
authors.forename: Rongchen
authors.initials: R
authors.lastname: Shi
authors.affiliation: Institute of Immunology, Third Military Medical University of PLA, Gaotanyan Street 30, Chongqing, 400038, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Institute of Immunology, Third Military Medical University of PLA, Gaotanyan Street 30, Chongqing, 400038, China. zhangzhiren@yahoo.com.
authors.forename: Zhiren
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D016827:CD8 Antigens / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
chemical_list: D016827:CD8 Antigens
keywords: CD8; Experimental autoimmune neuritis; Macrophages; T cells