title: Non-adherence to standard treatment guidelines in a rural paediatric hospital in Sierra Leone.
abstract: METHODS
  A rural paediatric hospital in Bo, Sierra Leone.
  
  
  OBJECTIVE
  To assess the level of adherence to standard treatment guidelines among clinicians prescribing treatment for children admitted with a diagnosis of malaria and/or lower respiratory tract infection (LRTI), and determine the association between (non) adherence and hospital outcomes, given that non-rational use of medicines is a serious global problem.
  
  
  METHODS
  Secondary analysis of routine programme data.
  
  
  RESULTS
  Data were collected for 865 children admitted with an entry diagnosis of malaria and 690 children with LRTI during the period January to April 2011; some patients were classified in both categories. Non-adherence to guidelines comprised use of non-standard drug regimens, dosage variations, non-standard frequency of administration and treatment duration. Cumulative non-adherence to guidelines for LRTI cases was 86%. For malaria, this involved 12% of patients. Potentially harmful non-adherence was significantly associated with an unfavourable hospital outcome, both for malaria and for LRTI cases.
  
  
  CONCLUSIONS
  Overall non-adherence to standard treatment guidelines by clinicians in a routine hospital setting is very high and influences hospital outcomes. This study advocates for the implementation of routine measures to monitor and improve rational drug use and the quality of clinical care in such hospitals.
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: De Bruycker
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Van den Bergh
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Dahmane
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Khogali
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Schiavetti
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Nzomukunda
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Alders
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Allaouna
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Cloquet
authors.affiliation: International Union Against Tuberculosis and Lung Disease (The Union), Paris, France.
authors.forename: D A
authors.initials: DA
authors.lastname: Enarson
authors.affiliation: The Union, South East Asia Regional Office, New Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Satyarayanan
authors.affiliation: Ministry of Health, Sierra Leone.
authors.forename: E
authors.initials: E
authors.lastname: Magbity
authors.affiliation: Operational Centre Brussels, Médecins Sans Frontières, Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Zachariah
keywords: Sierra Leone; hospital; non-adherence; operational research; rational drug use