title: Cortisol Profile Mediates the Relation Between Childhood Neglect and Pain and Emotional Symptoms among Patients with Fibromyalgia.
abstract: BACKGROUND
  The relation between childhood trauma and chronic pain and emotional symptoms in adulthood has been well-documented, although physiological mechanisms mediating this link have not been elaborated.
  
  
  OBJECTIVE
  This study examined the mediating role of cortisol profile in the linkage between childhood maltreatment and pain and emotional symptoms in individuals with fibromyalgia (FM).
  
  
  METHODS
  One hundred seventy-nine adults with FM first provided retrospective self-reports of childhood maltreatment, then attended a standardized session during which cortisol was sampled across 1.5 hours and, subsequently, completed assessments of daily pain, depressive symptoms, and anxiety. Latent growth curve modeling estimated the hypothesized mediation models.
  
  
  RESULTS
  Childhood neglect predicted a flattened cortisol profile, which, in turn, predicted elevated daily pain and emotional symptoms. The cortisol profile partially mediated the neglect-symptom relation.
  
  
  CONCLUSIONS
  Early maltreatment may exert enduring effects on endocrine regulation that contributes to pain and emotional symptoms in adults with chronic pain.
authors.affiliation: Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ, 85287-1104, USA. whyeung@asu.edu.|Institute for Interdisciplinary Salivary Bioscience Research, Arizona State University, Tempe, AZ, 85287, USA. whyeung@asu.edu.
authors.forename: Ellen W
authors.initials: EW
authors.lastname: Yeung
authors.affiliation: Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ, 85287-1104, USA.
authors.forename: Mary C
authors.initials: MC
authors.lastname: Davis
authors.affiliation: Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ, 85287-1104, USA.
authors.forename: Marissa C
authors.initials: MC
authors.lastname: Ciaramitaro
mesh_terms: D000328:Adult; D054523:Adult Survivors of Child Abuse / Q000523:psychology*; D000368:Aged; D001007:Anxiety / Q000150:complications / Q000378:metabolism / Q000523:psychology; D003863:Depression / Q000150:complications / Q000378:metabolism / Q000523:psychology; D004644:Emotions; D005260:Female; D005356:Fibromyalgia / Q000150:complications / Q000378:metabolism* / Q000523:psychology*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010146:Pain / Q000150:complications / Q000378:metabolism* / Q000523:psychology*; D012463:Saliva / Q000378:metabolism; D013997:Time Factors; D055815:Young Adult
chemical_list: D006854:Hydrocortisone
keywords: Anxiety; Childhood Maltreatment; Cortisol; Depression; Fibromyalgia; Pain