title: [Substance dependence and genetic polymorphisms].
abstract: It has been widely known that vulnerability to substance dependence varies widely among individual subjects. Individual differences can be attributed to both genetic and environmental factors, although the relative influence of each of these factors can be diverse. Numerous molecules have been identified to be involved in the etiology of substance dependence, as well as response to or metabolism of related substances. Further, many technologies of genotyping polymorphisms, most often single nucleotide polymorphisms (SNPs), have been developed and advanced, which has accelerated the understandings of many associations between various genetic polymorphisms and vulnerability to substance dependence. In this article, we review the evidence of these associations accumulated thus far.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishizawa
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D061891:Controlled Substances; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D019966:Substance-Related Disorders / Q000235:genetics*
chemical_list: D061891:Controlled Substances