title: Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer's Disease.
abstract: Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) accumulation in brain that is paralleled by Aβ(1-42) reduction in cerebrospinal fluid (CSF). We analyzed the pattern of Aβ peptides, including the N- and C-terminal truncated fragments, in brain and CSF from two familial and one sporadic AD cases. We found that (i) each patient is characterized by a distinct Aβ profile in CSF and brain deposits and (ii) the CSF Aβ pattern mirrors the Aβ profile of cerebral amyloid. These results suggest the existence of different molecular AD subtypes which can be recognized by CSF analysis, enabling patient stratification.
authors.affiliation: Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.
authors.forename: Marcella
authors.initials: M
authors.lastname: Catania
authors.affiliation: Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Fede
authors.affiliation: Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, Brescia, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Tonoli
authors.affiliation: Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, Brescia, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Benussi
authors.affiliation: Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Pasquali
authors.affiliation: Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Giaccone
authors.affiliation: Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Maderna
authors.affiliation: Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, Brescia, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Ghidoni
authors.affiliation: Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Tagliavini
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D006801:Humans
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers
keywords: Alzheimer’s disease; SELDI-TOF MS; amyloid-β; biomarker; cerebrospinal fluid