title: A prospective study of coffee intake and pancreatic cancer: results from the NIH-AARP Diet and Health Study.
abstract: BACKGROUND
  Evidence evaluating the association between type of coffee intake (caffeinated, decaffeinated) and risk of pancreatic cancer is limited.
  
  
  METHODS
  In the US NIH-AARP Diet and Health Study, we used Cox proportional hazards regression to estimate hazard ratios and 95% confidence intervals (CIs) for coffee intake and risk of pancreatic cancer among 457 366 US adults.
  
  
  RESULTS
  Over 4 155 256 person-years of follow-up, 1541 incident first primary pancreatic cancers occurred. Following detailed adjustment for tobacco smoking history, risk estimates for coffee drinking were not statistically significant; compared with never drinkers of coffee, the hazard ratios (95% CI) were 1.05 (0.85-1.30), 1.06 (0.86-1.31), 1.03 (0.85-1.25), 1.00 (0.79-1.25), and 1.24 (0.93-1.65) for <1, 1, 2-3, 4-5, and ≥6 cups per day, respectively (P-value for trend 0.46). The observed null association was consistent across all examined strata (sex, smoking status, coffee caffeination, and prevalent diabetes).
  
  
  CONCLUSIONS
  In a prospective study of coffee intake with the largest number of pancreatic cancer cases to date, we did not observe an association between total, caffeinated, or decaffeinated coffee intake and pancreatic cancer.
authors.affiliation: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Guertin
authors.affiliation: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.
authors.forename: N D
authors.initials: ND
authors.lastname: Freedman
authors.affiliation: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.
authors.forename: E
authors.initials: E
authors.lastname: Loftfield
authors.affiliation: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.
authors.forename: R Z
authors.initials: RZ
authors.lastname: Stolzenberg-Solomon
authors.affiliation: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA.
authors.forename: B I
authors.initials: BI
authors.lastname: Graubard
authors.affiliation: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.
authors.forename: R
authors.initials: R
authors.lastname: Sinha
mesh_terms: D000368:Aged; D003069:Coffee / Q000009:adverse effects*; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014481:United States / Q000453:epidemiology
chemical_list: D003069:Coffee