title: Clinical Diagnostic Biomarkers from the Personalization of Computational Models of Cardiac Physiology.
abstract: Computational modelling of the heart is rapidly advancing to the point of clinical utility. However, the difficulty of parameterizing and validating models from clinical data indicates that the routine application of truly predictive models remains a significant challenge. We argue there is significant value in an intermediate step towards prediction. This step is the use of biophysically based models to extract clinically useful information from existing patient data. Specifically in this paper we review methodologies for applying modelling frameworks for this goal in the areas of quantifying cardiac anatomy, estimating myocardial stiffness and optimizing measurements of coronary perfusion. Using these indicative examples of the general overarching approach, we finally discuss the value, ongoing challenges and future potential for applying biophysically based modelling in the clinical context.
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, Lambeth Wing, St. Thomas' Hospital, London, UK.
authors.forename: Pablo
authors.initials: P
authors.lastname: Lamata
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, Lambeth Wing, St. Thomas' Hospital, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Cookson
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, Lambeth Wing, St. Thomas' Hospital, London, UK. nicolas.smith@kcl.ac.uk.|Faculty of Engineering, University of Auckland, 20 Symonds St, Private Bag 92019, Auckland, 1142, New Zealand. nicolas.smith@kcl.ac.uk.
authors.forename: Nic
authors.initials: N
authors.lastname: Smith
mesh_terms: D003198:Computer Simulation; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D057285:Precision Medicine / Q000379:methods*
keywords: Anatomy; Cardiac computational models; Clinical biomarker; Coronary flow; Myocardial stiffness