title: Unstable Maternal Environment Affects Stress Response in Adult Mice in a Genotype-Dependent Manner.
abstract: Early postnatal events exert powerful effects on development, inducing persistent functional alterations in different brain network, such as the catecholamine prefrontal-accumbal system, and increasing the risk of developing psychiatric disorders later in life. However, a vast body of literature shows that the interaction between genetic factors and early environmental conditions is crucial for expression of psychopathologies in adulthood. We evaluated the long-lasting effects of a repeated cross-fostering (RCF) procedure in 2 inbred strains of mice (C57BL/6J, DBA/2), known to show a different susceptibility to the development and expression of stress-induced psychopathologies. Coping behavior (forced swimming test) and preference for a natural reinforcing stimulus (saccharine preference test) were assessed in adult female mice of both genotypes. Moreover, c-Fos stress-induced activity was assessed in different brain regions involved in stress response. In addition, we evaluated the enduring effects of RCF on catecholamine prefrontal-accumbal response to acute stress (restraint) using, for the first time, a new "dual probes" in vivo microdialysis procedure in mouse. RCF experience affects behavioral and neurochemical responses to acute stress in adulthood in opposite direction in the 2 genotypes, leading DBA mice toward an "anhedonic-like" phenotype and C57 mice toward an increased sensitivity for a natural reinforcing stimulus.
authors.affiliation: Santa Lucia Foundation, 00143 Rome, Italy.|Department of Psychology and "Daniel Bovet" Center and.
authors.forename: Matteo
authors.initials: M
authors.lastname: Di Segni
authors.affiliation: Santa Lucia Foundation, 00143 Rome, Italy.|Department of Science and Biomedical Technologies, University of L'Aquila, 67010 L'Aquila, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Andolina
authors.affiliation: Cell Biology and Neurobiology Institute, National Research Council, 00143 Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Luchetti
authors.affiliation: Department of Psychology and "Daniel Bovet" Center and.
authors.forename: Lucy
authors.initials: L
authors.lastname: Babicola
authors.affiliation: Department of Biology and Biotechnology "Charles Darwin,""La Sapienza" University, 00181 Rome, Italy.
authors.forename: Lina Ilaras
authors.initials: LI
authors.lastname: D'Apolito
authors.affiliation: Santa Lucia Foundation, 00143 Rome, Italy.|Department of Psychology and "Daniel Bovet" Center and.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Pascucci
authors.affiliation: Santa Lucia Foundation, 00143 Rome, Italy.|Department of Psychology and "Daniel Bovet" Center and.
authors.forename: David
authors.initials: D
authors.lastname: Conversi
authors.affiliation: Department of Psychology and "Daniel Bovet" Center and.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Accoto
authors.affiliation: Cell Biology and Neurobiology Institute, National Research Council, 00143 Rome, Italy.|Institut Universitaire en Santé Mentale de Québec, Laval University, Quebec, Canada.
authors.forename: Francesca R
authors.initials: FR
authors.lastname: D'Amato
authors.affiliation: Santa Lucia Foundation, 00143 Rome, Italy.|Department of Psychology and "Daniel Bovet" Center and.
authors.forename: Rossella
authors.initials: R
authors.lastname: Ventura
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005518:Food Preferences / Q000523:psychology; D005838:Genotype; D008297:Male; D008425:Maternal Behavior / Q000523:psychology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D017551:Microdialysis; D009638:Norepinephrine / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000235:genetics* / Q000503:physiopathology*; D013550:Swimming / Q000523:psychology
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D004298:Dopamine; D009638:Norepinephrine
keywords: anhedonia; dopamine; early environment; inbred strains; mice; prefrontal–accumbal system; stress