title: Probable interaction between acenocoumarol and levofloxacin: a case series.
abstract: OBJECTIVE
  To report five cases with a probable interaction between acenocoumarol and levofloxacin.
  
  
  METHODS
  In five patients on long-term acenocoumarol treatment who had had stable international normalized ratios for at least 6 months, sudden erratic changes in the values of these ratios were observed after 1.5-8 days of concomitant levofloxacin treatment with no other apparent cause.
  
  
  CONCLUSIONS
  Closer monitoring should be considered in patients with concomitant use of acenocoumarol and levofloxacin, especially elderly patients and those with renal dysfunction who seemed to suffer the interaction more severely.
authors.affiliation: Department of Pharmacy, Galdakao- Usansolo Hospital, Galdakao, Bizkaia, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Palacios-Zabalza
authors.affiliation: Department of Pharmacy, Galdakao- Usansolo Hospital, Galdakao, Bizkaia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Bustos-Martínez
authors.affiliation: Department of Pharmacy, Galdakao- Usansolo Hospital, Galdakao, Bizkaia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Peral-Aguirregoitia
authors.forename: M J
authors.initials: MJ
authors.lastname: Martínez-Bengoechea
authors.affiliation: Basque Unit of Pharmacovigilance, Galdakao- Usansolo Hospital, Galdakao, Bizkaia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Aguirre Gomez
mesh_terms: D000074:Acenocoumarol / Q000009:adverse effects* / Q000627:therapeutic use; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions / Q000502:physiology*; D005260:Female; D006801:Humans; D064704:Levofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D064704:Levofloxacin; D000074:Acenocoumarol
keywords: acenocoumarol; adverse effect; drug-drug interaction; levofloxacin