title: Iron-Catalyzed α-Alkylation of Ketones with Alcohols.
abstract: A general and benign iron-catalyzed α-alkylation reaction of ketones with primary alcohols has been developed. The key to success of the reaction is the use of a Knölker-type complex as catalyst (2 mol %) in the presence of Cs2 CO3 as base (10 mol %) under hydrogen-borrowing conditions. Using 2-aminobenzyl alcohol as alkylation reagent allows for the "green" synthesis of quinoline derivatives.
authors.affiliation: UMR 6226 CNRS, Université de Rennes 1, Institut des Sciences Chimiques de Rennes, Team "Organometallics: Materials and Catalysis, Centre for Catalysis and Green Chemistry, campus de Beaulieu, 35042 Rennes, Cedex (France).|Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, Rostock, 18059 (Germany).
authors.forename: Saravanakumar
authors.initials: S
authors.lastname: Elangovan
authors.affiliation: UMR 6226 CNRS, Université de Rennes 1, Institut des Sciences Chimiques de Rennes, Team "Organometallics: Materials and Catalysis, Centre for Catalysis and Green Chemistry, campus de Beaulieu, 35042 Rennes, Cedex (France). jean-baptiste.sortais@univ-rennes1.fr.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Sortais
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, Rostock, 18059 (Germany).
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
authors.affiliation: UMR 6226 CNRS, Université de Rennes 1, Institut des Sciences Chimiques de Rennes, Team "Organometallics: Materials and Catalysis, Centre for Catalysis and Green Chemistry, campus de Beaulieu, 35042 Rennes, Cedex (France). christophe.darcel@univ-rennes1.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Darcel
keywords: Friedländer reaction; alkylation; borrowing hydrogen; homogeneous catalysis; iron catalysts