title: Effects of Nanosized Lithium Carbonate Particles on the Functional Activity of Macrophages During Development of Hepatocarcinoma 29.
abstract: The functional activity of macrophages in response to injection of nanosized lithium carbonate particles after initiation of hepatocarcinoma 29 in male CBA mice was evaluated by the production of NO, arginase activity, and absorption of zymosan granules. In intact animals, NO production by peritoneal macrophages increased by 4 times and arginase activity 3.1 times in response to a single injection of nanosized particles into the hip muscle. The level of NO production by macrophages remained high after 4 and 5 injections, while arginase activity returned to normal. The level of phagocytic peritoneal macrophages increased by 1.4 times after 5 injections of the particles. The level of NO production by macrophages gradually increased in animals with hepatocarcinoma developing in the hip muscle: by 1.6 times on day 3, 3.2 times on day 7, and by 2.6 times on day 13 in comparison with the corresponding parameters in intact animals. The increase of NO production by peritoneal macrophages after tumor process initiation was not paralleled by changes in arginase activity and absorption of zymosan granules. The results indicated that injection of nanosized lithium carbonate particles after inoculation of hepatocarcinoma 29 cells in the right hip muscle tissue was inessential for the function of peritoneal macrophages by the studied parameters.
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Konenkov
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Borodin
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. opmak@ngs.ru.
authors.forename: O P
authors.initials: OP
authors.lastname: Makarova
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Bgatova
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Rachkovskaya
mesh_terms: D000818:Animals; D001119:Arginase / Q000378:metabolism; D063646:Carcinogenesis / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D019073:HT29 Cells; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D016651:Lithium Carbonate / Q000737:chemistry / Q000494:pharmacology*; D008113:Liver Neoplasms / Q000276:immunology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008808:Mice, Inbred CBA; D053758:Nanoparticles / Q000737:chemistry; D009368:Neoplasm Transplantation; D009569:Nitric Oxide / Q000096:biosynthesis; D010316:Particle Size; D010587:Phagocytosis
chemical_list: D007155:Immunologic Factors; D016651:Lithium Carbonate; D009569:Nitric Oxide; D001119:Arginase
keywords: arginase; hepatocarcinoma; macrophages; nanosized lithium carbonate particles; nitric oxide