title: Screening of differentially expressed genes in pathological scar tissues using expression microarray.
abstract: Pathological scar tissues and normal skin tissues were differentiated by screening for differentially expressed genes in pathologic scar tissues via gene expression microarray. The differentially expressed gene data was analyzed by gene ontology and pathway analyses. There were 5001 up- or down-regulated genes in 2-fold differentially expressed genes, 956 up- or down-regulated genes in 5-fold differentially expressed genes, and 114 up- or down-regulated genes in 20-fold differentially expressed genes. Therefore, significant differences were observed in the gene expression in pathological scar tissues and normal foreskin tissues. The development of pathological scar tissues has been correlated to changes in multiple genes and pathways, which are believed to form a dynamic network connection.
authors.affiliation: Department of Physical Therapy, Chinese PLA General Hospital, Beijing, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Huang
authors.affiliation: Department of Orthopedics, Chinese PLA General Hospital, Beijing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Mao
authors.affiliation: Dalian City Hospital of Traditional Chinese Medicine, Dalian, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Physical Therapy, Chinese PLA General Hospital, Beijing, China.
authors.forename: X X
authors.initials: XX
authors.lastname: Liu
authors.affiliation: Key Laboratory of Molecular Cytogenetics and Genetic Breeding of Heilongjiang Province, College of Life Science and Technology, Harbin Normal University, Harbin, Heilongjiang, China.
authors.forename: C
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Physical Therapy, Chinese PLA General Hospital, Beijing, China wangxl301@126.com.
authors.forename: Z S
authors.initials: ZS
authors.lastname: Jia
mesh_terms: D000328:Adult; D002921:Cicatrix / Q000209:etiology / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005499:Folliculitis / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D052816:Foreskin / Q000166:cytology / Q000378:metabolism; D005667:Furunculosis / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D063990:Gene Ontology; D006801:Humans; D008297:Male; D053858:Metabolic Networks and Pathways / Q000235:genetics; D058977:Molecular Sequence Annotation; D020411:Oligonucleotide Array Sequence Analysis; D011506:Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D011506:Proteins