title: The use of fluorescein sodium in the biopsy and gross-total resection of a tectal plate glioma.
abstract: Intravenous administration of fluorescein sodium fluoresces glioma burden tissue and can be visualized using the surgical microscope with a specialized filter. Intraoperative guidance afforded through the use of fluorescein may enhance the fidelity of tissue sampling, and increase the ability to accomplish complete resection of tectal lesions. In this report the authors present the case of a 19-year-old man with a tectal anaplastic pilocytic astrocytoma in which the use of fluorescein sodium and a Zeiss Pentero surgical microscope equipped with a yellow 560 filter enabled safe complete resection. In conjunction with neurosurgical navigation, added intraoperative guidance provided by fluorescein may be beneficial in the resection of brainstem gliomas.
authors.affiliation: Department of Neurological Surgery, and.
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Ung
authors.affiliation: Department of Neurological Surgery, and.
authors.forename: Christopher
authors.initials: C
authors.lastname: Kellner
authors.affiliation: Department of Neurological Surgery, and.
authors.forename: Justin A
authors.initials: JA
authors.lastname: Neira
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
authors.forename: Shih-Hsiu J
authors.initials: SH
authors.lastname: Wang
authors.affiliation: Department of Neurological Surgery, and.
authors.forename: Randy
authors.initials: R
authors.lastname: D'Amico
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
authors.forename: Phyllis L
authors.initials: PL
authors.lastname: Faust
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
authors.forename: Peter
authors.initials: P
authors.lastname: Canoll
authors.affiliation: Department of Neurological Surgery, and.
authors.forename: Neil A
authors.initials: NA
authors.lastname: Feldstein
authors.affiliation: Department of Neurological Surgery, and.
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Bruce
mesh_terms: D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D001706:Biopsy / Q000379:methods*; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D003399:Craniotomy / Q000379:methods; D019793:Fluorescein / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008853:Microscopy / Q000295:instrumentation / Q000379:methods; D060787:Neoplasm Grading; D044583:Neuroendoscopy; D003336:Tectum Mesencephali / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D020542:Third Ventricle / Q000601:surgery*; D014018:Tissue Distribution; D014696:Ventriculostomy / Q000379:methods*; D055815:Young Adult
chemical_list: D019793:Fluorescein
keywords: anaplastic; fluorescein sodium; oncology; pilocytic astrocytoma; quadrigeminal plate lesion; tectal plate glioma