title: Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats.
abstract: To determine the relationship between fibroblast growth factor 5 (FGF5) and FGF5-short (FGF5s) in dermal papilla cells of cashmere goat primary and secondary hair follicles. We isolated dermal papilla cells from primary hair follicle (PHF) and secondary hair follicle (SHF) of cashmere goat, and found that the FGF5 receptor, fibroblast growth factor receptor 1 (FGFR1), was expressed in these two types of dermal papilla cells. Moreover, adenovirus-mediated overexpression of FGF5 could upregulate the mRNA expression of insulin-like growth factor-1 (IGF-1), versican and noggin that were important for follicle growth maintenance, whereas downregulate the expression of anagen chalone bone morphogenetic protein 4 (BMP4) in dermal papilla cells. However, these alterations were partly reversed by FGF5s overexpression. In conclusion, our results demonstrated that FGF5s acted as an inhibitor of FGF5 in the regulation of anagen-catagen transition of cashmere goat dermal papilla cells.
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address: hesibonnie0@163.com.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: He
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China. Electronic address: yuch_0294215@126.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chao
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address: royouzhouguang@126.com.
authors.forename: Guangxian
authors.initials: G
authors.lastname: Zhou
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address: chenyulin@nwafu.edu.cn.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Chen
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D055415:Bone Morphogenetic Protein 4 / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D002478:Cells, Cultured; D000229:Dependovirus / Q000235:genetics; D051521:Fibroblast Growth Factor 5 / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation; D006041:Goats; D018859:Hair Follicle / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D020033:Protein Isoforms / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000378:metabolism; D053675:Versicans / Q000235:genetics; D000099176:Noggin Protein
chemical_list: D055415:Bone Morphogenetic Protein 4; D002352:Carrier Proteins; D051521:Fibroblast Growth Factor 5; D007334:Insulin-Like Growth Factor I; D020033:Protein Isoforms; D012333:RNA, Messenger; D051496:Receptor, Fibroblast Growth Factor, Type 1; D053675:Versicans; D000099176:Noggin Protein
keywords: Cashmere goat; Dermal papilla cell; FGF5; Primary hair follicle; Secondary hair follicle