title: Hypertriglyceridemia in extremely low birth weight infants receiving lipid emulsions.
abstract: OBJECTIVE
  To determine the prevalence of high TG levels in extremely low birth weight (ELBW) infants and what the risk factors are for high TG levels.
  
  
  METHODS
  We performed a prospective observational study of triglyceride concentrations in extremely low birth weight infants receiving lipid infusions. Lipid infusions were begun at 0.5 grams/kg/day at age one day and the dose advanced by 0.5 grams/kg/day. Triglyceride concentrations were drawn when the dose reached 1 and 2 grams/kg/day. We compared infants with normal triglyceride levels (≤200 mg/dl) with those with elevated triglyceride levels (>200 mg/dl) with univariate and multivariate analysis.
  
  
  RESULTS
  There were 75 infants included in the analysis. Twenty (26.7% , 95% CI = 16.6-36.7%) had triglyceride levels >200 mg/dl. On multiple logistic regression analysis, lower birth weight was associated with the risk of an elevated triglyceride level. Triglyceride levels >200 mg/dl did not predict future mortality or morbidity.
  
  
  CONCLUSIONS
  Elevated TG levels occur commonly in ELBW infants and are associated with a lower birth weight.
authors.affiliation: Department of Pediatrics, William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.
authors.forename: P
authors.initials: P
authors.lastname: Holtrop
authors.affiliation: Department of Pediatrics, William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.
authors.forename: T
authors.initials: T
authors.lastname: Swails
authors.affiliation: William Beaumont Hospital Research Institute, Beaumont Children's Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.
authors.forename: T
authors.initials: T
authors.lastname: Riggs
mesh_terms: D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D015228:Hypertriglyceridemia / Q000453:epidemiology / Q000209:etiology*; D007223:Infant; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008074:Lipoproteins; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000379:methods*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014481:United States / Q000453:epidemiology
chemical_list: D005217:Fat Emulsions, Intravenous; D008074:Lipoproteins; D014280:Triglycerides
keywords: Neonates; lipids; triglyceride concentrations