title: A novel actor in antitumoral immunity: The thymus-specific serine protease TSSP/PRSS16 involved in CD4+T-cell maturation.
abstract: The maturation of a specific subset of CD4+T lymphocytes in the thymus is dependent on cortical thymic epithelial cells expressing the protease thymus-specific serine protease (TSSP, also known as PRSS16). Recently, we unveiled the involvement of TSSP in tumor suppression through its effect on the CD4+T compartment.
authors.affiliation: Inserm; U1068; CRCM ; Marseille, France ; Institut Paoli-Calmettes ; Marseille, France ; Aix-Marseille Université ; Marseille, France ; CNRS; UMR7258; CRCM ; Marseille, France.
authors.forename: Lydie
authors.initials: L
authors.lastname: Brisson
authors.affiliation: Inserm; U1068; CRCM ; Marseille, France ; Institut Paoli-Calmettes ; Marseille, France ; Aix-Marseille Université ; Marseille, France ; CNRS; UMR7258; CRCM ; Marseille, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Carrier
keywords: CD4+ T cells; TSSP; colitis-associated colorectal cancer; thymus; tumor suppression