title: Slowed peak resting frequency and MEG overactivation in survivors of severe sepsis and septic shock.
abstract: OBJECTIVE
  Survivors of severe sepsis and septic shock suffer from residual severe cognitive impairments, which persist even years after intensive care unit (ICU) discharge. As the awareness of long-term consequences gradually grows, research has focused on cognitive impairments via questionnaires, but only few have focused on structural or electrophysiological features, such as the peak resting frequency, which is commonly seen as a hallmark of brain function.
  
  
  METHODS
  We aimed to analyze the long-term progression of the peak resting activity in terms of frequency and power in sepsis survivors. Healthy individuals with no history of ICU stay served as controls. Data were collected three times (shortly, 6 and 12 months after ICU discharge) in sepsis survivors and three times in controls. Participants also underwent behavioral neuropsychological assessment.
  
  
  RESULTS
  Sepsis survivors exhibited significantly higher spectral power of the dominant peak, which was shifted towards lower frequencies. Within one year, resting frequency increased to the level of controls, but power did not decrease. We observed a close correlation between resting frequency and mental status.
  
  
  CONCLUSIONS
  Results support the assumption of a causal relationship between brain oscillations and behavioral performance.
  
  
  CONCLUSIONS
  We suggest that the postseptic frequency shift is due to abnormal thalamocortical dynamics.
authors.affiliation: Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; CSCC, Center for Sepsis Control and Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: theresa@biomag.uni-jena.de.
authors.forename: Theresa
authors.initials: T
authors.lastname: Götz
authors.affiliation: Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; CSCC, Center for Sepsis Control and Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: Philipp.Baumbach@med.uni-jena.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Baumbach
authors.affiliation: Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; CSCC, Center for Sepsis Control and Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: rhuonker@biomag.uni-jena.de.
authors.forename: Ralph
authors.initials: R
authors.lastname: Huonker
authors.affiliation: Neuropsychology Lab, Department of Psychology, Cluster of excellence "Hearing4all", European Medical School, University of Oldenburg, 26111 Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Germany. Electronic address: cornelia.kranczioch@uni-oldenburg.de.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Kranczioch
authors.affiliation: Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: otto.witte@med.uni-jena.de.
authors.forename: Otto W
authors.initials: OW
authors.lastname: Witte
authors.affiliation: Neuropsychology Lab, Department of Psychology, Cluster of excellence "Hearing4all", European Medical School, University of Oldenburg, 26111 Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Germany. Electronic address: stefan.debener@uni-oldenburg.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Debener
authors.affiliation: Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany; Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: carsten.klingner@med.uni-jena.de.
authors.forename: Carsten
authors.initials: C
authors.lastname: Klingner
authors.affiliation: Center for Clinical Studies, Jena University Hospital, Salvador-Allende-Platz 27, 07747 Jena, Germany. Electronic address: Frank.Brunkhorst@med.uni-jena.de.
authors.forename: Frank M
authors.initials: FM
authors.lastname: Brunkhorst
authors.affiliation: Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: albrecht.guenther@med.uni-jena.de.
authors.forename: Albrecht
authors.initials: A
authors.lastname: Günther
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015225:Magnetoencephalography / Q000639:trends*; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge / Q000639:trends; D012146:Rest / Q000502:physiology*; D018805:Sepsis / Q000175:diagnosis / Q000503:physiopathology*; D012772:Shock, Septic / Q000175:diagnosis / Q000503:physiopathology*; D017741:Survivors; D013997:Time Factors
keywords: Long-term cognitive impairments; Magnetoencephalography; Neuronal oscillations; Resting activity; Sepsis