title: Hepatitis B seropositivity and risk of developing multiple myeloma or Hodgkin lymphoma: A meta-analysis of observational studies.
abstract: Multiple myeloma (MM) and Hodgkin lymphoma (HL) are common hematological malignancies. There is conflicting data on the potential role of hepatitis B virus (HBV) infection and developing MM or HL. The main aim of this study is to evaluate the association of HBV seropositivity and HL or MM through a meta-analysis of epidemiological studies A literature search through March 2015 found 10 studies that evaluated the association between HBV and MM or HL. Meta-analysis was calculated as an odds ratio (OR). Our analysis showed an OR of developing MM of 1.41 (P=0.03) and an OR of developing HL of 1.54 (P=0.03) in patients with HBV seropositivity. Our results did not change based on study design, quality of studies and use of HBV seropositivity to determine HBV status. Our results suggest that HBV seropositivity increases the risk of developing MM and HL. Further research is needed to confirm these findings.
authors.affiliation: Oncology and Hematology Mercy Clinic Joplin, 100 Mercy Way, Joplin, MO 64804, United States. Electronic address: sdalia@gmail.com.
authors.forename: Samir
authors.initials: S
authors.lastname: Dalia
authors.affiliation: Morsani College of Medicine, The University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, United States. Electronic address: kdunker@health.usf.edu.
authors.forename: Kelli
authors.initials: K
authors.lastname: Dunker
authors.affiliation: Division of Hematological Malignancies, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States. Electronic address: Lubomir.sokol@moffitt.org.
authors.forename: Lubomir
authors.initials: L
authors.lastname: Sokol
authors.affiliation: Division of Evidence Based Medicine, Department of Internal Medicine, The University of South Florida, 12901 Bruce B Downs Blvd MDC 27, Tampa, FL 33612, United States. Electronic address: rmhaskar@health.usf.edu.
authors.forename: Rahul
authors.initials: R
authors.lastname: Mhaskar
mesh_terms: D001208:Asia / Q000453:epidemiology; D001315:Australia / Q000453:epidemiology; D016022:Case-Control Studies; D015984:Causality; D015331:Cohort Studies; D015897:Comorbidity; D000068598:Data Accuracy; D019353:Endemic Diseases; D005060:Europe / Q000453:epidemiology; D006509:Hepatitis B / Q000453:epidemiology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006689:Hodgkin Disease / Q000209:etiology*; D006801:Humans; D009101:Multiple Myeloma / Q000453:epidemiology*; D064887:Observational Studies as Topic; D016017:Odds Ratio; D012306:Risk; D016036:Seroepidemiologic Studies
chemical_list: D006510:Hepatitis B Antibodies
keywords: Hepatitis B; Hodgkin Lymphoma; Meta-analysis; Multiple myeloma