title: Immunological biomarkers in dermatomyositis.
abstract: Dermatomyositis (DM) is a chronic acquired disorder that affects primarily the muscle and skin. The pathogenesis of DM, as well as methods for monitoring disease activity and predicting response to therapy, are subjects of active research. Studies looking to unveil the pathogenesis of DM have revealed key molecules that are potential biomarkers of disease activity. This article reviews briefly the recently discovered molecules that are candidate immunological biomarkers for diagnosing and monitoring disease activity in DM.
authors.affiliation: Division of Rheumatology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA. olazagastilourido.jeannette@mayo.edu.
authors.forename: Jeannette M
authors.initials: JM
authors.lastname: Olazagasti
authors.affiliation: Division of Rheumatology and Department of Immunology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA. niewold.timothy@mayo.edu.
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Niewold
authors.affiliation: Department of Pediatrics and Division of Rheumatology, Duke University School of Medicine, 201 Trent Drive, Durham, NC, 27710, USA. ann.reed@duke.edu.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Reed
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism*; D003882:Dermatomyositis / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism; D012867:Skin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D018925:Chemokines
keywords: Biomarkers; Chemokines; Cytokines; Dermatomyositis; Toll-like receptors; Type I interferon