title: Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata.
abstract: The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day (BID) in a murine neutropenic model of systemic infection with S. capitata by testing a set of six clinical isolates. Posaconazole showed fungistatic activity against all of the isolates tested. The different doses of the drug, especially the highest one, showed good efficacy, measured by prolonged survival, reduction of (1-3)-β-D-glucan levels in serum, tissue burden reduction, and histopathology.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Pamela
authors.initials: P
authors.lastname: Thomson
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
authors.affiliation: Unitat de Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain javier.capilla@urv.cat.
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D001487:Basidiomycota / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D001921:Brain / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D016867:Immunocompromised Host; D007668:Kidney / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D008297:Male; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology* / Q000401:mortality; D009503:Neutropenia / Q000382:microbiology; D011509:Proteoglycans; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D047071:beta-Glucans / Q000097:blood
chemical_list: D000935:Antifungal Agents; D011509:Proteoglycans; D014230:Triazoles; D047071:beta-Glucans; C010770:polysaccharide-K; C101425:posaconazole