title: DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population.
abstract: The susceptibility to glioma is not well understood. It has been suggested that the X-ray cross complementing group 3 (XRCC3) gene influences the capacity to repair DNA damage, leading to increased glioma susceptibility. In this study, we evaluated the relationship between XRCC3 mutations and glioma risk. Genotypes were assessed in 389 Chinese glioma patients and 358 healthy controls. XRCC3 Thr241Met (rs861539) and 2 additional polymorphisms, rs3212112 (c.774+19T>G) and rs1799796 (c.562-14A>G), were directly sequenced. The frequency of the rs861539 T allele was significantly lower in the glioma group than in healthy controls [11.1 vs 17.7%, odds ratio = 0.62 (0.48-0.80), P < 0.001]; the frequencies of the CT or CT+TT genotypes differed between groups (18.5 vs 31%, 20.3 vs 33.2%, respectively). The frequency of the rs3212112 G allele was significantly higher in the glioma group than in healthy controls [15.8 vs 5.3%, odds ratio = 2.94 (2.07-4.17), P < 0.001]. The frequencies of the GT or TG+GG genotypes differed between groups (25.4 vs 7.8%, 28.5 vs 9.2%, respectively). This study demonstrates that the rs861539 and rs3212112 polymorphisms in the XRCC3 gene may influence the risk of glioma development in Chinese populations.
authors.affiliation: Operation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: J F
authors.initials: JF
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Qu
authors.affiliation: Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: J
authors.initials: J
authors.lastname: Qu
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: F E
authors.initials: FE
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: T
authors.initials: T
authors.lastname: Xiong
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: S H
authors.initials: SH
authors.lastname: Lu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D001932:Brain Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017422:Sequence Analysis, DNA
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3