title: Overexpression of PI3K-p110α in the progression of uterine cervical neoplasia and its correlation with pAkt and DJ-1.
abstract: OBJECTIVE
  To investigate the expression of PI3K-p110α, pAkt, PTEN, the signaling molecules from PI3K/Akt signaling pathway, DJ-1, an oncoprotein and HSP90a, a molecular chaperone, and their correlation in uterine cervical neoplasia, in order to elucidate their role in cervical carcinogenesis.
  
  
  METHODS
  Using immunohistochemistry, the authors analyzed the expression of PI3K-p110α, pAkt, PTEN, DJ-1 and HSP90α, and their correlation in ten normal tissues, cervical intraepithelial neoplasia (CIN) including 30 CIN1 and 31 CIN3, and 33 cases of invasive squamous cell carcinoma (SCC).
  
  
  RESULTS
  The expression of all proteins significantly increased in CIN3 compared to CIN1, and only the expression of PI3K-p110α significantly increased in invasive SCC compared to CIN3. There was a significant positive correlation between the expression of PI3K-p110α and DJ-1, as well as PI3K-p110α and pAkt in CIN3 and invasive SCC.
  
  
  CONCLUSIONS
  Overexpression of PI3K-p110α is associated with progression of uterine cervical neoplasia, and the expression of pAkt and DJ-1 is positively correlated with PI3K-p110α expression in this process.
authors.forename: S K
authors.initials: SK
authors.lastname: Choi
authors.forename: Y O
authors.initials: YO
authors.lastname: Hong
authors.forename: W M
authors.initials: WM
authors.lastname: Lee
authors.forename: E K
authors.initials: EK
authors.lastname: Kim
authors.forename: J E
authors.initials: JE
authors.lastname: Joo
authors.forename: D W
authors.initials: DW
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Lee
mesh_terms: D058543:Class Ia Phosphatidylinositol 3-Kinase / Q000032:analysis / Q000502:physiology*; D018450:Disease Progression; D005260:Female; D018841:HSP90 Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis / Q000502:physiology*; D015513:Oncogene Proteins / Q000032:analysis / Q000502:physiology*; D051059:PTEN Phosphohydrolase / Q000032:analysis; D000071617:Protein Deglycase DJ-1; D051057:Proto-Oncogene Proteins c-akt / Q000032:analysis / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
chemical_list: D018841:HSP90 Heat-Shock Proteins; D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; D058543:Class Ia Phosphatidylinositol 3-Kinase; D051057:Proto-Oncogene Proteins c-akt; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human