title: Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs.
abstract: Post-transcriptional control of gene expression is mediated by RNA-binding proteins (RBPs) and small non-coding RNAs (e.g., microRNAs) that bind to distinct elements in their mRNA targets. Here, we review recent examples describing the synergistic and/or antagonistic effects mediated by RBPs and miRNAs to determine the localisation, stability and translation of mRNAs in mammalian cells. From these studies, it is becoming increasingly apparent that dynamic rearrangements of RNA-protein complexes could have profound implications in human cancer, in synaptic plasticity, and in cellular differentiation.
authors.affiliation: Department of Microbial & Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK. v.iadevaia@surrey.ac.uk.
authors.forename: Valentina
authors.initials: V
authors.lastname: Iadevaia
authors.affiliation: Department of Microbial & Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK. a.gerber@surrey.ac.uk.
authors.forename: André P
authors.initials: AP
authors.lastname: Gerber
mesh_terms: D000818:Animals; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D022661:RNA, Untranslated; D016601:RNA-Binding Proteins
keywords: RNA-binding protein; combinatorial control; gene expression; microRNA; post-transcriptional control; ribonucleoprotein complex