title: Disseminated Mycobacterium avium complex disease in a patient with left ventricular assist device (Heart Mate II).
abstract: Although disseminated Mycobacterium avium complex disease occurs mainly in immunocompromised hosts, especially HIV-infected patients in the last stage of the disease (AIDS), this condition is still rare in immunocompetent subjects. We report the case of a Caucasian man who received a left ventricular assist device two years before as a bridge to heart transplantation, that began to present signs and symptoms of mycobacterial infection. The diagnostic work-up we performed showed the presence of Mycobacterium intracellulare in lungs and both peripherical and bone marrow blood. Although evaluated, we found no abnormalities in the patient's immune system that can be related to mycobacterial infection. The beginning of a specific therapy made the patient slowly improve and further nuclear medicine assay (PET-TC) showed a good reduction in radio-labelled drug captation.
authors.affiliation: Division of Infectious Diseases, Department of Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico "G.B. Rossi", Verona, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Cordioli
authors.affiliation: Division of Infectious Diseases, Department of Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico "G.B. Rossi", Verona, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Del Bravo
authors.affiliation: Division of Infectious Diseases, Department of Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico "G.B. Rossi", Verona, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Rigo
authors.affiliation: Division of Infectious Diseases, Department of Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico "G.B. Rossi", Verona, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Azzini
authors.affiliation: Division of Infectious Diseases, Department of Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico "G.B. Rossi", Verona, Italy.
authors.forename: Mara
authors.initials: M
authors.lastname: Merighi
authors.affiliation: Division of Cardiothoracic Surgery, Department of Cardiovascular and Thoracic Surgery, Azienda Ospedaliera Universitaria Integrata di Verona, Ospedale Civile Maggiore, Verona, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Forni
authors.affiliation: Division of Infectious Diseases, Department of Pathology, Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico "G.B. Rossi", Verona, Italy.
authors.forename: Ercole
authors.initials: E
authors.lastname: Concia
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006333:Heart Failure; D006353:Heart-Assist Devices / Q000009:adverse effects; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D015269:Mycobacterium avium Complex / Q000187:drug effects / Q000302:isolation & purification*; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents