title: Gd3+-1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-2-hydroxypropyl-β-cyclodextrin/Pluronic Polyrotaxane as a Long Circulating High Relaxivity MRI Contrast Agent.
abstract: A multivalent magnetic resonance imaging agent based on a 2-hydroxypropyl-β-cyclodextrin (HPCD):Pluronic F127 polyrotaxane carrier has been synthesized, and its blood pool contrast properties have been characterized. This Gd3+-DO3A-HPCD/Pluronic polyrotaxane construct is shown to circulate for more than 30 min and provide >100-fold vascular enhancement relative to the monomeric Gd3+-DO3A-HPCD control that is rapidly cleared via the kidney. The high r1 relaxivity at 37 °C (23.83 mM(-1) s(-1) at 1.5 T; 34.08 mM(-1) s(-1) at 0.5 T), extended blood circulation, well-known pharmacology of the polyrotaxane precursors, and absence of acute toxicity make it a highly attractive blood pool contrast agent candidate.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: Zhuxian
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, Multi-disciplinary Cancer Research Facility, Purdue University , 1203 W. State Street, West Lafayette, Indiana 47907, United States.
authors.forename: Yawo
authors.initials: Y
authors.lastname: Mondjinou
authors.affiliation: Department of Chemistry, Multi-disciplinary Cancer Research Facility, Purdue University , 1203 W. State Street, West Lafayette, Indiana 47907, United States.
authors.forename: Seok-Hee
authors.initials: SH
authors.lastname: Hyun
authors.affiliation: Department of Chemistry, Multi-disciplinary Cancer Research Facility, Purdue University , 1203 W. State Street, West Lafayette, Indiana 47907, United States.
authors.forename: Aditya
authors.initials: A
authors.lastname: Kulkarni
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: Zheng-Rong
authors.initials: ZR
authors.lastname: Lu
authors.affiliation: Department of Chemistry, Multi-disciplinary Cancer Research Facility, Purdue University , 1203 W. State Street, West Lafayette, Indiana 47907, United States.
authors.forename: David H
authors.initials: DH
authors.lastname: Thompson
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D020442:Poloxamer / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*; D014018:Tissue Distribution; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: C520644:1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid; D003287:Contrast Media; D056831:Coordination Complexes; D003505:Cyclodextrins; D006573:Heterocyclic Compounds, 1-Ring; D043862:Rotaxanes; D047392:beta-Cyclodextrins; C475673:polyrotaxane; D020442:Poloxamer; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D005682:Gadolinium
keywords: 2-hydroxypropyl-β-cyclodextrin; Gd3+-DO3A; Pluronic; blood pool MR agent; long circulation; magnetic resonance contrast agent; polyrotaxane