title: Twenty-four-hour efficacy of preservative-free tafluprost for open-angle glaucoma patients, assessed by home intraocular pressure (Icare-ONE) and blood-pressure monitoring.
abstract: OBJECTIVE
  To evaluate the effect of preservative-free (PF) tafluprost on diurnal variation of intraocular pressure (IOP) and ocular perfusion pressure (OPP), measured by use of home IOP and blood-pressure (BP) monitoring devices, for primary open angle glaucoma (POAG) patients.
  
  
  METHODS
  Twenty-two eyes from 22 patients with POAG were studied. Initially, IOP was measured at the hospital by Goldmann applanation tonometry (GAT) and Icare-ONE rebound tonometry. Each patient was then instructed how to use the Icare-ONE and BP home monitoring devices. IOP and BP were measured at home by the patients, every 4 h, before and 2 weeks after once daily treatment with PF tafluprost (0.0015%) ophthalmic solution.
  
  
  RESULTS
  Intraclass correlations between different IOP measurements were greater than 0.8. PF tafluprost reduced mean diurnal IOP significantly for patients with POAG, from 15.7 ± 1.2 mmHg at baseline to 12.5 ± 0.6 mmHg 2 weeks after treatment (p < 0.001). It increased mean diurnal OPP from 48.5 ± 7.3 mmHg at baseline to 51.3 ± 7.0 mmHg post-treatment (p < 0.017).
  
  
  CONCLUSIONS
  Icare-ONE enables glaucoma patients to measure their own diurnal IOP fluctuations. Patient-measured Icare-ONE IOP readings showed that PF tafluprost effectively reduced diurnal IOP in eyes with POAG.
authors.affiliation: Department of Ophthalmology, Dongguk University College of Medicine, Gyeongju, Korea.
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Cho
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. yongykim@korea.ac.kr.
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
authors.forename: Chungkwon
authors.initials: C
authors.lastname: Yoo
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
authors.forename: Tae-Eun
authors.initials: TE
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory / Q000295:instrumentation; D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D009884:Ophthalmodynamometry; D011310:Preservatives, Pharmaceutical; D011446:Prospective Studies; D011460:Prostaglandins F / Q000627:therapeutic use*; D014065:Tonometry, Ocular / Q000295:instrumentation; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical; D011460:Prostaglandins F; C485333:tafluprost
keywords: Intraocular pressure; Ocular perfusion pressure; Rebound tonometer; Tafluprost