title: Multiple paths to peroxisomes: Mechanism of peroxisome maintenance in mammals.
abstract: Peroxisomes are dynamic organelles that can adjust their size and number in response to cellular demand and environmental stimuli. They can propagate from pre-existing peroxisomes through growth and division, as well as de novo from the endoplasmic reticulum (ER). However, to what extend that these two distinct peroxisome biogenesis pathways are involved in maintaining peroxisome numbers in cycling cells is unclear. Recent studies in yeast suggest that the ER plays a direct role in the maintenance of peroxisomes. However, the role of the ER in mammalian system is under debate. In this review, we outline the recent progress in understanding the biogenesis of mammalian peroxisomes. We herein discuss some of the discrepancies in the literature and the outstanding questions in the field.
authors.affiliation: Program in Cell Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 0A4; Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5G 1A8.
authors.forename: Rong
authors.initials: R
authors.lastname: Hua
authors.affiliation: Program in Cell Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 0A4; Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5G 1A8. Electronic address: pkim@sickkids.ca.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Kim
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008074:Lipoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism; D001678:Organelle Biogenesis; D000074401:Peroxins; D020675:Peroxisomes / Q000737:chemistry / Q000378:metabolism*; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D008074:Lipoproteins; D008565:Membrane Proteins; C486345:PEX16 protein, human; D000074401:Peroxins; C113138:Pex3 protein, human; D020033:Protein Isoforms; C087343:PEX19 protein, human
keywords: Endoplasmic reticulum; Growth and division; Mammalian peroxisomes; Mitochondria; Peroxisomal membrane protein; de novo biogenesis