title: [Expression of transient receptor potential lvanilloidreceptor 4 protein in autoimmune bullous skin disorders].
abstract: OBJECTIVE
  To investigate the expression of transient receptor potential lvanilloidreceptor 4 (TRPV4) protein in pemphigus vulgaris (PV), bullous pemphigoid (BP), dermatitis herpetiformis (DH), and epidermolysis bullosa acquisita (EBA), and explore the role of TRPV4 in the pathogenesis of these diseases.
  
  
  METHODS
  TRPV4 protein in normal skin tissues and lesions of PV, BP, DH, and EBA were detected with immunohistochemistry.
  
  
  RESULTS
  The positivity rate of TRPV4 protein expression was 61.90% in PV, 81.81% in BP, 72.22% in DH, and 68.42% in EBA. TRPV4-positive rates in these lesions were significantly lower than the rate in normal skin tissues (93.33%) and also differed significantly among these lesions (PV<EBA<DH<BP).
  
  
  CONCLUSIONS
  Low TRPV4 expressions may affect the formation and reconstitution of skin connection. TRPV4 may play an role in the occurrence and development of autoimmune bullous skin disorders.
authors.affiliation: Department of Dermatology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China.E-mail: baijie_0927@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.forename: Xingwei
authors.initials: X
authors.lastname: Zou
authors.forename: Yougui
authors.initials: Y
authors.lastname: Jiang
authors.forename: Qiongyu
authors.initials: Q
authors.lastname: Wang
mesh_terms: D003874:Dermatitis Herpetiformis / Q000378:metabolism*; D003937:Diagnosis, Differential; D016107:Epidermolysis Bullosa Acquisita / Q000378:metabolism*; D006801:Humans; D010391:Pemphigoid, Bullous / Q000378:metabolism*; D010392:Pemphigus / Q000378:metabolism*; D012867:Skin / Q000473:pathology; D050916:TRPV Cation Channels / Q000378:metabolism*
chemical_list: D050916:TRPV Cation Channels; C416986:TRPV4 protein, human