title: [Controversial Issues in Economic Evaluation (III): health Care Interventions in Special Situations].
abstract: The development of the economic evaluation of health care interventions has become a support tool in making decisions on pricing and reimbursement of new health interventions. The increasingly extensive application of these techniques has led to the identification of particular situations in which, for various reasons, it may be reasonable to take into account special considerations when applying the general principles of economic evaluation. In this article, which closes a series of three, we will discuss, using the Metaplan technique, about the economic evaluation of health interventions in special situations such as rare diseases and end of life treatments, as well as consideration of externalities in assessments, finally pointing out some research areas to solve the main problems identified in these fields.
authors.forename: Jaime
authors.initials: J
authors.lastname: Espín Balbino
authors.forename: Max
authors.initials: M
authors.lastname: Brosa Riestra
authors.forename: Juan
authors.initials: J
authors.lastname: Oliva Moreno
authors.forename: Marta
authors.initials: M
authors.lastname: Trapero-Bertran
mesh_terms: D003362:Cost-Benefit Analysis / Q000941:ethics*; D017048:Health Care Costs / Q000941:ethics*; D006801:Humans; D017063:Outcome Assessment, Health Care / Q000191:economics / Q000941:ethics; D035583:Rare Diseases / Q000191:economics* / Q000628:therapy; D013030:Spain; D013727:Terminal Care / Q000191:economics* / Q000941:ethics