title: Periodontal clinical and microbiological characteristics in healthy versus generalized aggressive periodontitis families.
abstract: OBJECTIVE
  Generalized aggressive periodontitis (GAP) is a severe and multifactorial disease in which a familial aggregation and a specific microbiological profile have been suggested. Thus, this case-control study evaluated the clinical and subgingival microbial profile of GAP subjects and their families compared to healthy families.
  
  
  METHODS
  Fifteen families with parents presenting periodontal health and 15 with parents with a history of GAP were selected. Each family should have at least one child between 6 and 12 years old. Plaque index (PI), gingival index (GI), and periodontal probing depth (PPD), as well as Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans (Aa) amounts (by qPCR), were assessed from all subjects.
  
  
  RESULTS
  Children of GAP families showed a higher PI, GI, and PPD when compared to children of healthy families (p ≤ 0.05). A higher frequency of detection and amounts of Aa was observed in GAP children compared to children of healthy families (p ≤ 0.05). Moreover, a significant association between Aa amounts and gingival bleeding was observed in children (p ≤ 0.05, r = 0.37).
  
  
  CONCLUSIONS
  Children from GAP families have worst clinical conditions, i.e. higher levels of PI, GI, and PPD, a more pathogenic microbiological profile, and the amount of Aa are associated with a higher marginal inflammation.
authors.affiliation: Division of Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Mabelle de F
authors.initials: Mde F
authors.lastname: Monteiro
authors.affiliation: Division of Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Marcio Z
authors.initials: MZ
authors.lastname: Casati
authors.affiliation: Division of Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Tiago
authors.initials: T
authors.lastname: Taiete
authors.affiliation: Division of Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Hugo F do
authors.initials: HF
authors.lastname: Vale
authors.affiliation: Division of Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Francisco Humberto
authors.initials: FH
authors.lastname: Nociti
authors.affiliation: Division of Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Enilson Antônio
authors.initials: EA
authors.lastname: Sallum
authors.affiliation: Division of Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Karina G
authors.initials: KG
authors.lastname: Silvério
authors.affiliation: Division of Periodontics, Paulista University, Piracicaba, São Paulo, Brazil.
authors.forename: Renato C V
authors.initials: RC
authors.lastname: Casarin
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans; D010520:Aggressive Periodontitis / Q000382:microbiology*; D001439:Bacteroides; D016022:Case-Control Studies; D002648:Child; D003773:Dental Plaque; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D008297:Male; D017622:Periodontal Attachment Loss; D010512:Periodontal Index; D010514:Periodontal Pocket; D016966:Porphyromonas gingivalis
keywords: Aggregatibacter actinomycetemcomitans; generalized aggressive periodontitis; hereditarily; prevention; susceptibility factors