title: Investigation of Morphological and Functional Changes in the Small Intestine With Pancreatic Disease.
abstract: OBJECTIVE
  The aim of this study was to investigate the relationship between pancreas and small intestine evaluating the endoscopic and histopathologic findings of the proximal small intestine in pancreatic diseases.
  
  
  METHODS
  Fifty patients (18 patients with chronic pancreatitis, 17 patients with pancreatic cancer, 15 control subjects) underwent enteroscopy using a prototype enteroscope. The villous height of the jejunum on bioptic specimens was measured, and the mean values of the villi were compared among the 3 groups. Exocrine function was calculated by the pancreatic function diagnostic test, and the correlation between the recovery rate of p-aminobenzoic acid and the villous height was assessed. Finally, the distribution of the K cells secreting glucose-dependent insulinotropic polypeptide and the L cells secreting glucagon-like peptide 1 in the duodenum and jejunum was investigated using immunohistochemistry for glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1.
  
  
  RESULTS
  The mean villous height in chronic pancreatitis (328 ± 67 μm) was significantly lower than that in pancreatic cancer (413 ± 57 μm) and control subjects (461 ± 97 μm) (P = 0.004 and P < 0.0001, respectively). A positive correlation was found between the recovery rate of p-aminobenzoic acid and the villous height (r = 0.52, P = 0.0001). The presence of K and L cells was verified in the duodenum and the jejunum.
  
  
  CONCLUSIONS
  Close relationship between pancreas and small intestine was demonstrated.
authors.affiliation: From the *Department of Endoscopy, Nagoya University Hospital; †Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine; and ‡Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Itoh
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawashima
authors.forename: Eizaburo
authors.initials: E
authors.lastname: Ohno
authors.forename: Yuya
authors.initials: Y
authors.lastname: Itoh
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hiramatsu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Sumi
authors.forename: Daijuro
authors.initials: D
authors.lastname: Hayashi
authors.forename: Takamichi
authors.initials: T
authors.lastname: Kuwahara
authors.forename: Kohei
authors.initials: K
authors.lastname: Funasaka
authors.forename: Masanao
authors.initials: M
authors.lastname: Nakamura
authors.forename: Ryoji
authors.initials: R
authors.lastname: Miyahara
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohmiya
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Katano
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishigami
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Shimoyama
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hirooka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D004386:Duodenum / Q000378:metabolism / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D006801:Humans; D007583:Jejunum / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010186:Pancreatic Function Tests; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000503:physiopathology; D050500:Pancreatitis, Chronic / Q000473:pathology* / Q000503:physiopathology
chemical_list: D052216:Glucagon-Like Peptide 1