title: Associations between interleukin and interleukin receptor gene polymorphisms and risk of gout.
abstract: Gout is a self-limiting, auto-inflammatory arthritis induced by the deposition of monosodium urate crystals in the synovial fluid and periarticular tissues. The aim of this study was to investigate the associations between genetic variants in the interleukin (IL) and interleukin receptor (ILR) genes IL-33, IL-1RL1, IL-23R, and signal transducer and activator of transcription 4 (STAT4) and susceptibility to gout in Chinese Han male individuals. The genetic distributions of rs3939286 in IL-33, rs13015714 in IL-1RL1, rs10889677 in IL-23R, and rs7574865 in STAT4 were detected in 1100 men with gout and 1227 ethnically matched controls, using Taqman allelic discrimination real-time polymerase chain reaction (PCR). Differences in these polymorphisms between the groups were investigated using χ(2) tests. The genotype-phenotype relationship among gout patients was tested by analysis of variance. There was a significant difference in genotypic frequencies of IL-23R rs10889677 between gout patients and controls (χ(2) = 81.386, P < 0.001). However, there were no significant differences in distributions of the other polymorphisms between the groups. Our results revealed that the rs10889677 variant in IL-23R may be involved in the development of gout in Chinese Han male individuals. However, further studies in other ethnic groups are needed to confirm these results.
authors.affiliation: Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China.|Shandong Provincial Key Laboratory of Metabolic Disease, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.affiliation: Institute of Clinical Research, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Disease, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Can
authors.initials: C
authors.lastname: Wang
authors.affiliation: Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Mingzhen
authors.initials: M
authors.lastname: Guo
authors.affiliation: Qingdao HaiCi hospital, Qingdao, 266003, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Chu
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Disease, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Changgui
authors.initials: C
authors.lastname: Li
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006073:Gout / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D012306:Risk
chemical_list: D007378:Interleukins; D018123:Receptors, Interleukin