title: Serum lipid profile and inflammatory markers in the aorta of cholesterol-fed rats supplemented with extra virgin olive oil, sunflower oils and oil-products.
abstract: Extra virgin olive oil (EVOO) major and minor component anti-inflammatory effect on aorta was evaluated; Wistar rats were fed (9 weeks) on either a high-cholesterol diet (HCD) or a HCD supplemented with oils, i.e. EVOO, sunflower oil (SO), high-oleic sunflower oil (HOSO), or oil-products modified to their phenolic content, i.e. phenolics deprived-EVOO [EVOO(-)], SO enriched with the EVOO phenolics [SO(+)], HOSO enriched with the EVOO phenolics [HOSO(+)]. HCD induced dyslipidemia and resulted in higher aorta adhesion molecules levels at euthanasia. Groups receiving EVOO, EVOO(-), HOSO, HOSO(+) presented higher serum TC and LDL-c levels compared to cholesterol-fed rats; attenuation of aorta E-selectin levels was also observed. In EVOO/EVOO(-) groups, aorta vascular endothelial adhesion molecule-1 (VCAM-1) was lower compared to HCD animals. SO/SO(+) diets had no effect on endothelial dysfunction amelioration. Overall, our results suggest that major and/or minor EVOO constituents improve aorta E-selectin and VCAM-1, while serum lipids do not benefit.
authors.affiliation: a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .
authors.forename: Ageliki I
authors.initials: AI
authors.lastname: Katsarou
authors.affiliation: a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .
authors.forename: Andriana C
authors.initials: AC
authors.lastname: Kaliora
authors.affiliation: b Experimental-Research Center ELPEN , Pikermi , Athens , Greece , and.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Papalois
authors.affiliation: a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .
authors.forename: Antonia
authors.initials: A
authors.lastname: Chiou
authors.affiliation: a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .
authors.forename: Nick
authors.initials: N
authors.lastname: Kalogeropoulos
authors.affiliation: c Laboratory of Pathology , School of Medicine, University of Athens , Athens , Greece.
authors.forename: George
authors.initials: G
authors.lastname: Agrogiannis
authors.affiliation: a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .
authors.forename: Nikolaos K
authors.initials: NK
authors.lastname: Andrikopoulos
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002791:Cholesterol, Dietary / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D019587:Dietary Supplements; D019040:E-Selectin / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D006368:Helianthus / Q000737:chemistry; D006937:Hypercholesterolemia / Q000097:blood / Q000209:etiology / Q000473:pathology; D007249:Inflammation / Q000097:blood / Q000517:prevention & control*; D008297:Male; D031658:Olea / Q000737:chemistry; D019301:Oleic Acid / Q000494:pharmacology / Q000627:therapeutic use; D000069463:Olive Oil / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D017208:Rats, Wistar; D000074242:Sunflower Oil; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D019040:E-Selectin; D000069463:Olive Oil; D010636:Phenols; D010936:Plant Extracts; D010938:Plant Oils; D000074242:Sunflower Oil; D019010:Vascular Cell Adhesion Molecule-1; D019301:Oleic Acid
keywords: E-selectin; VCAM-1; olive oil; polar phenolic compounds; serum lipid profile; sunflower oil