title: Near-infrared spectroscopy-intravascular ultrasound: scientific basis and clinical applications.
abstract: Coronary angiography underestimates the magnitude of the atherosclerotic burden and cannot detect the presence of disease in the early phases. Recognition of these inherent limitations of angiography has been an impetus for the development of other coronary imaging techniques. The novel near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) catheters can detect and quantify the presence of lipid core in the atherosclerotic plaque and associate it with other features such as lumen size and plaque architecture. Lipid-rich plaques are known to pose a higher risk of distal embolization during interventions and plaque disruption. The aim of this manuscript is the review of the potential clinical and research applications of this technology as highlighted by recent studies.
authors.affiliation: The NIHR Cardiovascular BRU, Royal Brompton Hospital, London, UK Department of Cardiology, Pamukkale University Hospitals, Denizli, Turkey.
authors.forename: Ismail Dogu
authors.initials: ID
authors.lastname: Kilic
authors.affiliation: The NIHR Cardiovascular BRU, Royal Brompton Hospital, London, UK.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Caiazzo
authors.affiliation: The NIHR Cardiovascular BRU, Royal Brompton Hospital, London, UK Cardiovascular Department, 'Ospedali Riuniti' and University of Trieste, Trieste, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Fabris
authors.affiliation: The NIHR Cardiovascular BRU, Royal Brompton Hospital, London, UK.
authors.forename: Roberta
authors.initials: R
authors.lastname: Serdoz
authors.affiliation: The NIHR Cardiovascular BRU, Royal Brompton Hospital, London, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Abou-Sherif
authors.affiliation: Infraredx Inc., Burlington, MA, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Madden
authors.affiliation: The Mount Sinai Hospital, New York, NY, USA.
authors.forename: Pedro R
authors.initials: PR
authors.lastname: Moreno
authors.affiliation: Department of Cardiovascular Medicine, Beaumont Hospital, Royal Oak, MI, USA.
authors.forename: James
authors.initials: J
authors.lastname: Goldstein
authors.affiliation: The NIHR Cardiovascular BRU, Royal Brompton Hospital, London, UK c.dimario@rbht.nhs.uk.
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Mario
mesh_terms: D006801:Humans; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods*
keywords: intravascular ultrasound; lipid core; near-infrared spectroscopy; vulnerable plaque