title: Oscillations in pedunculopontine nucleus in Parkinson's disease and its relationship with deep brain stimulation.
abstract: The recent development of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) for the treatment of parkinsonian patients, particularly those in advanced stages with axial symptoms, has ignited interest into the study of this brain nucleus. In contrast to the extensively studied alterations of neural activity that occur in the basal ganglia in Parkinson's disease (PD), our understanding of the activity of the PPN remains insufficient. In recent years, however, a series of studies recording oscillatory activity in the PPN of parkinsonian patients have made important findings. Here, we briefly review recent studies that explore the different kinds of oscillations observed in the PPN of parkinsonian patients, and how they underlie the pathophysiology of PD and the efficacy of PPN-DBS in these disorders.
authors.affiliation: The National Key Clinic Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Engineering Technology Research Center of Education Ministry of China, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University Guangzhou, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: The National Key Clinic Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Engineering Technology Research Center of Education Ministry of China, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University Guangzhou, China.
authors.forename: Wangming
authors.initials: W
authors.lastname: Zhang
mesh_terms: D046690:Deep Brain Stimulation; D055724:Electrophysiological Phenomena / Q000502:physiology*; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D045042:Pedunculopontine Tegmental Nucleus / Q000503:physiopathology*
keywords: Parkinson’s disease; deep brain stimulation; local field potentials; oscillations; pedunculopontine nucleus