title: Characteristics of Mononuclear Extracellular Traps in the Offspring of Female Rats with Drug-Induced Hepatitis.
abstract: We studied the effect of experimental tetracycline-induced liver injury in mothers on the capacity of macrophages from various compartments to form traps and on activity of extracellular macrophage traps in the offspring. Trap-forming capacity was evaluated by the number of traps. We found reduction in the number and suppression of activity of the macrophage extracellular traps in the offspring of females with experimental liver injury. The findings suggest that mothers with drug-induced liver injury produce physiologically immature offspring with reduced unspecific resistance.
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: G V
authors.initials: GV
authors.lastname: Bryukhin
authors.affiliation: Chelyabinsk State University, Chelyabinsk, Russia. viktoriya_malinina@list.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Shopova
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology*; D065206:Extracellular Traps / Q000502:physiology*; D005260:Female; D008099:Liver; D008264:Macrophages / Q000276:immunology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology*; D017208:Rats, Wistar
keywords: activity of macrophagal traps; extracellular traps; killing activity; liver injury; offspring