title: Dynamics of Multi-stage Infections on Networks.
abstract: This paper investigates the dynamics of infectious diseases with a non-exponentially distributed infectious period. This is achieved by considering a multi-stage infection model on networks. Using pairwise approximation with a standard closure, a number of important characteristics of disease dynamics are derived analytically, including the final size of an epidemic and a threshold for epidemic outbreaks, and it is shown how these quantities depend on disease characteristics, as well as the number of disease stages. Stochastic simulations of dynamics on networks are performed and compared to output of pairwise models for several realistic examples of infectious diseases to illustrate the role played by the number of stages in the disease dynamics. These results show that a higher number of disease stages results in faster epidemic outbreaks with a higher peak prevalence and a larger final size of the epidemic. The agreement between the pairwise and simulation models is excellent in the cases we consider.
authors.affiliation: Department of Mathematics, University of Sussex, Brighton, BN1 9QH, UK.
authors.forename: N
authors.initials: N
authors.lastname: Sherborne
authors.affiliation: Department of Mathematics, University of Sussex, Brighton, BN1 9QH, UK. k.blyuss@sussex.ac.uk.
authors.forename: K B
authors.initials: KB
authors.lastname: Blyuss
authors.affiliation: Department of Mathematics, University of Sussex, Brighton, BN1 9QH, UK.
authors.forename: I Z
authors.initials: IZ
authors.lastname: Kiss
mesh_terms: D003141:Communicable Diseases / Q000453:epidemiology* / Q000635:transmission; D003198:Computer Simulation; D058872:Epidemics / Q000706:statistics & numerical data; D006801:Humans; D007251:Influenza, Human / Q000453:epidemiology / Q000635:transmission; D055641:Mathematical Concepts; D008954:Models, Biological; D045169:Severe Acute Respiratory Syndrome / Q000453:epidemiology / Q000635:transmission; D012899:Smallpox / Q000453:epidemiology / Q000635:transmission; D013269:Stochastic Processes
keywords: Final size; Infectious period; Network; Pairwise approximation