title: The Multifarious Hippocampal Functions of MicroRNA-137.
abstract: MicroRNAs (miRs) have emerged as a powerful class of endogenous noncoding RNAs involved in posttranscriptional gene expression regulation. miR-137 has repeatedly been associated with schizophrenia and intellectual disability. Recent studies describe the mechanisms of miR-137 in mediating basic synaptic transmission and plasticity in the hippocampus. A picture is emerging in which miR-137 acts as a potent player in regulating glutamatergic synaptic transmission in the hippocampus by controlling the translation of functionally critical genes at spatially opposite ends of the synapse, contributing to the pathogenesis of cognitive impairments as seen in neurodevelopmental disorders.
authors.affiliation: Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Nijmegen, Netherlands.
authors.forename: Aron
authors.initials: A
authors.lastname: Kos
authors.affiliation: Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Nijmegen, Netherlands.
authors.forename: Armaz
authors.initials: A
authors.lastname: Aschrafi
authors.affiliation: Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Nijmegen, Netherlands Department of Human Genetics, Radboud University Medical Centre, Nijmegen, Netherlands n.nadif@donders.ru.nl.
authors.forename: Nael
authors.initials: N
authors.lastname: Nadif Kasri
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009473:Neuronal Plasticity / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D012559:Schizophrenia / Q000235:genetics; D013569:Synapses / Q000235:genetics* / Q000378:metabolism
chemical_list: C545567:MIRN137 microRNA, human; D035683:MicroRNAs
keywords: epigenetics; glutamatergic neurons; intellectual disability; neurotransmission; noncoding RNA; schizophrenia; trisynaptic loop