title: miR-206 is an independent prognostic factor and inhibits tumor invasion and migration in colorectal cancer.
abstract: microRNAs (miRNAs) are small non-coding RNAs that play important role in a variety of biological processes, and aberrant expression of miRNA is always associated with tumor progression and invasion. However, the role of miR-206 in colorectal cancer (CRC) is still unclear. In this study, the expression of miR-206 in CRC tissue was compared to paired normal adjacent tissue, and results indicate that miRNA-206 levels are significantly lower in CRC tissue compared to control tissue. Kaplan-Meier analysis showed that patients with low miR-206 expression had significantly poorer overall survival. In addition, we found that over-expression of miR-206 can inhibit CRC cell migration and invasion. In conclusion, our results suggest that miR-206 functions as a tumor suppressor by inhibiting CRC migration and invasion. These findings suggest that miR-206 may be useful as a new potential therapeutic target for CRC.
authors.affiliation: Department of gastrointestinal surgery, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Pengda
authors.initials: P
authors.lastname: Sun
authors.affiliation: Ethics Committee, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of gastrointestinal surgery, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of gastrointestinal surgery, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Tianzhou
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of gastrointestinal surgery, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Gastroenterology, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Duan
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D045325:HCT116 Cells; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C546087:MIRN206 microRNA, human; D035683:MicroRNAs
keywords: cell growth and invasion; colorectal cancer; miR-206; prognosis