title: Evaluation of Intracameral Amphotericin B in the Management of Fungal Keratitis: Randomized Controlled Trial.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of intracameral amphotericin B (ICAMB) in the management of fungal keratitis.
  
  
  METHODS
  In total, 45 eyes with smear-confirmed fungal keratitis with hypopyon were randomized into three treatment groups: Group I (topical antifungal treatment + oral antifungal); Group II (topical antifungal treatment + ICAMB + oral antifungal); and Group III (topical antifungal treatment + drainage of hypopyon + ICAMB + oral antifungal). The main outcome measures were treatment success rate, time to heal, visual acuity gain, and presence of complications.
  
  
  RESULTS
  There were no differences in the treatment success rates (p = 0.66), time to healing (p = 0.18), or mean final visual acuity (logMAR) (p = 0.8) between the three groups. The major complication observed was increased incidence of cataract in group III (40%), though it was statistically insignificant.
  
  
  CONCLUSIONS
  ICAMB does not offer any benefit over topical antifungal therapy when performed alone or associated with drainage of hypopyon.
authors.affiliation: a Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
authors.forename: Namrata
authors.initials: N
authors.lastname: Sharma
authors.affiliation: a Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
authors.forename: Preeti
authors.initials: P
authors.lastname: Sankaran
authors.affiliation: a Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
authors.forename: Tushar
authors.initials: T
authors.lastname: Agarwal
authors.affiliation: a Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
authors.forename: Tarun
authors.initials: T
authors.lastname: Arora
authors.affiliation: a Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
authors.forename: Bhavna
authors.initials: B
authors.lastname: Chawla
authors.affiliation: a Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
authors.forename: Jeewan S
authors.initials: JS
authors.lastname: Titiyal
authors.affiliation: a Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
authors.forename: Radhika
authors.initials: R
authors.lastname: Tandon
authors.affiliation: a Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
authors.forename: Gita
authors.initials: G
authors.lastname: Satapathy
authors.affiliation: a Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.|b Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital , Melbourne , Australia.
authors.forename: Rasik B
authors.initials: RB
authors.lastname: Vajpayee
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000867:Anterior Chamber / Q000187:drug effects; D000935:Antifungal Agents / Q000627:therapeutic use*; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B
keywords: Fungal keratitis; fungal organisms; intracameral amphotericin; mycotic keratitis; recalcitrant fungal keratitis