title: Deep Brain Recordings Using an Implanted Pulse Generator in Parkinson's Disease.
abstract: OBJECTIVE
  Recent studies suggest that oscillatory beta activity could be used as a state biomarker in patients with Parkinson's disease for subthalamic closed-loop stimulation with the intention of improving clinical benefit. Here we investigate the feasibility of subthalamic recordings via a novel chronically implanted pulse generator.
  
  
  METHODS
  Subthalamic local field potential recordings were obtained from eight patients before and during deep brain stimulation (DBS). All data were analyzed in the frequency domain using Fourier transform-based methods and compared between ON and OFF stimulation conditions.
  
  
  RESULTS
  Distinct peaks of oscillatory beta band activity were found in 12 of 15 electrodes. DBS induced a significant frequency specific suppression of oscillatory beta activity (p = 0.002).
  
  
  CONCLUSIONS
  The results of the study suggest that oscillatory beta band synchronization and its modulation by DBS is recordable with a system suitable for chronic implantation and may serve as a biomarker for subthalamic closed-loop stimulation in patients with Parkinson's disease.
authors.affiliation: Department of Neurology, Campus Virchow Klinikum, Charité - University Medicine Berlin, Berlin, Germany.
authors.forename: Wolf-Julian
authors.initials: WJ
authors.lastname: Neumann
authors.affiliation: Department of Neurology, Campus Virchow Klinikum, Charité - University Medicine Berlin, Berlin, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Staub
authors.affiliation: Department of Neurology, Campus Virchow Klinikum, Charité - University Medicine Berlin, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Horn
authors.affiliation: Department of Neurology, Campus Virchow Klinikum, Charité - University Medicine Berlin, Berlin, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Schanda
authors.affiliation: Department of Neurology, Vivantes Hospital Berlin Spandau, Berlin, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Mueller
authors.affiliation: Department of Neurosurgery, Campus Virchow Klinikum, Charité - University Medicine Berlin, Berlin, Germany.
authors.forename: Gerd-Helge
authors.initials: GH
authors.lastname: Schneider
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.|Medical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Brown
authors.affiliation: Department of Neurology, Campus Virchow Klinikum, Charité - University Medicine Berlin, Berlin, Germany.|Berlin School of Mind and Brain, Charité - University Medicine Berlin, Berlin, Germany.|NeuroCure, Charité - University Medicine Berlin, Berlin, Germany.
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Kühn
mesh_terms: D000368:Aged; D001703:Biophysics; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D013057:Spectrum Analysis; D020531:Subthalamic Nucleus / Q000166:cytology* / Q000502:physiology*
keywords: Basal ganglia; beta oscillations; deep brain stimulation; local field potentials; subthalamic nucleus