title: Comparison of 12-month clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion lesions: a multicenter study.
abstract: OBJECTIVE
  This study aimed to compare 1-year clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion (CTO) lesions.
  
  
  METHODS
  A total of 2865 patients (age 62.82±10.64 years; 74.0% men) undergoing percutaneous coronary intervention for CTO were analyzed. The patients were classified as diabetic (n=977) or nondiabetic (n=1888). One-year clinical outcomes were compared between the two groups.
  
  
  RESULTS
  One year after percutaneous coronary intervention, 241 (8.4%) patients developed major adverse cardiac events (MACEs). Target lesion revascularization (TLR), target vessel revascularization (TVR), TLR-MACEs, and total MACEs were more common in diabetics than in nondiabetics (6.1 vs. 3.9%, P=0.021; 7.2 vs. 4.8%, P=0.023; 7.7 vs. 5.5%, P=0.017; and 10.3 vs. 7.7%, P=0.011; respectively). In multivariate analysis, diabetes mellitus was an independent predictor for 1-year TLR (odds ratio: 2.201, P=0.001) and total MACEs (odds ratio: 1.677, P=0.002). Among diabetic patients, total death, TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs were more common in patients who used insulin than in those who did not (6.1 vs. 1.9%, P=0.018; 11.3 vs. 4.6%, P=0.007; 12.2 vs. 5.9%, P=0.025; 14.8 vs. 5.9%, P=0.003; 16.5 vs. 8.0%, P=0.008; and 17.4 vs. 9.2%, P=0.012, respectively). Insulin use was an independent predictor for total death, 12-month TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs.
  
  
  CONCLUSIONS
  This study identified diabetes mellitus as an independent risk factor for 1-year TLR and total MACEs in patients with CTO lesions.
authors.affiliation: aCardiovascular Center, Korea University Guro Hospital bSamsung Medical Center, Sungkyunkwan University School of Medicine cSeverance Cardiovascular Hospital, Yonsei University College of Medicine dSeoul National University Hospital eKorea University Anam Hospital, Seoul fKyungpook National University Hospital gCardiovascular Center, Keimyung University Dongsan Medical Center, Daegu hSeoul National University Bundang Hospital, Seongnam-si iWonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju jDong-A University Hospital, Busan kChonnam National University Hospital, Gwangju, Korea.
authors.forename: Seung-Woon
authors.initials: SW
authors.lastname: Rha
authors.forename: Cheol Ung
authors.initials: CU
authors.lastname: Choi
authors.forename: Jin Oh
authors.initials: JO
authors.lastname: Na
authors.forename: Hong Euy
authors.initials: HE
authors.lastname: Lim
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Eung Ju
authors.initials: EJ
authors.lastname: Kim
authors.forename: Chang Gyu
authors.initials: CG
authors.lastname: Park
authors.forename: Hong Seog
authors.initials: HS
authors.lastname: Seo
authors.forename: Dong Joo
authors.initials: DJ
authors.lastname: Oh
authors.forename: Hyeon-Cheol
authors.initials: HC
authors.lastname: Gwon
authors.forename: Byeong-Keuk
authors.initials: BK
authors.lastname: Kim
authors.forename: Hyo-Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Cheol Woong
authors.initials: CW
authors.lastname: Yu
authors.forename: Hun Sik
authors.initials: HS
authors.lastname: Park
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Chae
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Moo Hyun
authors.initials: MH
authors.lastname: Kim
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Hur
authors.forename: Young-Keun
authors.initials: YK
authors.lastname: Ahn
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000401:mortality*; D016022:Case-Control Studies; D015897:Comorbidity; D054059:Coronary Occlusion / Q000453:epidemiology / Q000601:surgery*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology*; D009204:Myocardial Revascularization / Q000706:statistics & numerical data*; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention; D012042:Registries; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin