title: Association between SNPs in vascular endothelial growth factor polymorphisms and risk of renal cell carcinoma: a case-control study.
abstract: We conducted this case-control study to assess the role of the VEGF -2578C/A, +1612G/A, +936C/T and -634G/C gene polymorphisms in the development of renal cell carcinoma (RCC). A hospital-based case-control study was conducted in a 360 consecutive primary RCC patients and 360 age and gender-matched controls during January 2010 and January 2014. The polymerase chain reaction-restriction fragment length polymorphism was used for VEGF -2578C/A, +1612G/A, +936C/T and -634G/C genotyping. Multivariate conditional logistic regression analyses showed that subjects carrying the AA and the CA+AA genotypes of VEGF -2578C/A had significant association with increased risk of RCC compared to those having the CC genotype, and the ORs (95%CI) were 1.77 (1.10-2.85) and 1.37 (1.01-1.86), respectively. Using the conditional logistic regression model, CA+AA genotype of VEGF -2578C/A had a significantly increased risk of RCC in ever cigarette smokers, and individuals with hypertension, and the ORs (95%CI) were 1.93 (1.08-3.45) and 2.57 (1.06-6.57), respectively. In conclusion, our results showed that AA genotype of VEGF -2578C/A genetic variants is associated with increased risk of RCC.
authors.affiliation: Department of Renal Transplantation, Zhengzhou People's Hospital, Zhengzhou, China shenbeili_zph2@163.com.
authors.forename: B-L
authors.initials: BL
authors.lastname: Shen
authors.affiliation: Department of Renal Transplantation, Zhengzhou People's Hospital, Zhengzhou, China.
authors.forename: Q-S
authors.initials: QS
authors.lastname: Qu
authors.affiliation: Department of Renal Transplantation, Zhengzhou People's Hospital, Zhengzhou, China.
authors.forename: S-Z
authors.initials: SZ
authors.lastname: Miao
authors.affiliation: Department of Renal Transplantation, Zhengzhou People's Hospital, Zhengzhou, China.
authors.forename: Y-X
authors.initials: YX
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A