title: Is the time interval between HCG administration and oocyte retrieval associated with oocyte retrieval rate?
abstract: The aim of this study was to evaluate whether prolongation of the time interval between HCG administration and oocyte retrieval, from 36 h to 38 h, affects oocyte retrieval rate in women undergoing ovarian stimulation with gonadotrophins and GnRH antagonists for IVF. One hundred and fifty-six normo-ovulatory women were randomized to have oocyte retrieval performed 36 h (n = 78) or 38 h (n = 78) following HCG administration. Oocyte retrieval rate was defined as number of cumulus-oocyte-complex (COC) retrieved/follicle ≥ 11 mm present on day of HCG administration. No significant differences were observed between the groups regarding baseline characteristics. Moreover, no significant difference was observed between the groups regarding oocyte retrieval rate (difference: + 1.2%, 95% CI for difference between medians: -4.5 to +12.1). The median (95% CI for the median) was not significantly different between the groups regarding number of cumulus-oocyte-complexes (COCs) retrieved: 5.5 (5.0-7.0) versus 6.0 (5.0-6.2), respectively, and fertilization rates: 57.7% (50.0-66.7) versus 50.0% (44.8-65.5), respectively. Live birth rates were similar between the groups (20.5% versus 16.7%, RD: + 3.8%, 95% CI: -8.5 to +16.1, respectively). Prolongation of time interval between HCG administration and oocyte retrieval from 36 h to 38 h does not affect oocyte retrieval rate.
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address: juliabosdou@gmail.com.
authors.forename: Julia K
authors.initials: JK
authors.lastname: Bosdou
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Efstratios M
authors.initials: EM
authors.lastname: Kolibianakis
authors.affiliation: Women's and Children's Health, St George Hospital, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Christos A
authors.initials: CA
authors.lastname: Venetis
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Zepiridis
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Katerina
authors.initials: K
authors.lastname: Chatzimeletiou
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Anastasios
authors.initials: A
authors.lastname: Makedos
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Stylianos
authors.initials: S
authors.lastname: Triantafyllidis
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Sevasti
authors.initials: S
authors.lastname: Masouridou
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Mitsoli
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Basil
authors.initials: B
authors.lastname: Tarlatzis
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000627:therapeutic use; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D054315:Oocyte Retrieval / Q000379:methods*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female
keywords: antagonists; gonadotropins; oocyte retrieval rate; ovarian stimulation; randomized clinical trial