title: Biocompatible and biodegradable nanoparticles for enhancement of anti-cancer activities of phytochemicals.
abstract: Many phytochemicals show promise in cancer prevention and treatment, but their low aqueous solubility, poor stability, unfavorable bioavailability, and low target specificity make administering them at therapeutic doses unrealistic. This is particularly true for (-)-epigallocatechin gallate, curcumin, quercetin, resveratrol, and genistein. There is an increasing interest in developing novel delivery strategies for these natural products. Liposomes, micelles, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and poly (lactide-co-glycolide) nanoparticles are biocompatible and biodegradable nanoparticles. Those nanoparticles can increase the stability and solubility of phytochemicals, exhibit a sustained release property, enhance their absorption and bioavailability, protect them from premature enzymatic degradation or metabolism, prolong their circulation time, improve their target specificity to cancer cells or tumors via passive or targeted delivery, lower toxicity or side-effects to normal cells or tissues through preventing them from prematurely interacting with the biological environment, and enhance anti-cancer activities. Nanotechnology opens a door for developing phytochemical-loaded nanoparticles for prevention and treatment of cancer.
authors.affiliation: Department of Nutritional Sciences, Texas Tech University, Lubbock TX 79409, USA; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Nutritional Sciences, Texas Tech University, Lubbock TX 79409, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Nutritional Sciences, Texas Tech University, Lubbock TX 79409, USA.
authors.forename: Yu-Jiao
authors.initials: YJ
authors.lastname: Zu
authors.affiliation: Nutrilite Health Institute, Buena Park, CA 90622, USA.
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Nie
authors.affiliation: Department of Nutritional Sciences, Texas Tech University, Lubbock TX 79409, USA; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Hematology and Oncology, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Ze-Yuan
authors.initials: ZY
authors.lastname: Deng
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Xie
authors.affiliation: Department of Nutritional Sciences, Texas Tech University, Lubbock TX 79409, USA. Electronic address: shu.wang@ttu.edu.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000627:therapeutic use; D004337:Drug Carriers; D006801:Humans; D008422:Materials Testing; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*; D064209:Phytochemicals / Q000008:administration & dosage* / Q000627:therapeutic use; D010936:Plant Extracts / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D064209:Phytochemicals; D010936:Plant Extracts
keywords: (−)-Epigallocatechin Gallate; Biocompatible; Biodegradable; Cancer; Curcumin; Genistein; Nanoparticles; Quercetin; Resveratrol