title: All pain, no gain: Tc17 phantoms in GVHD.
abstract: Elusive CD8+ T cells that transiently secrete interleukin (IL)-17 cause graft-versus-host disease (GVHD) but do not contribute to beneficial graft-versus-leukemia (GVL) responses, as reported by Gartlan et al in this issue of Blood. GVHD remains a lethal and morbid complication of allogeneic bone marrow transplantation, but GVHD is tightly linked to beneficial GVL effects, and removal of donor T cells that cause GVHD also diminish GVL, leading to greater relapse after bone marrow transplantation (BMT). This elegant paper from the laboratory of Geoffrey Hill has identified a rare “night fury” T-cell subset that causes much pain with no gain, a finding that may take us one large step closer to the long sought after goal of separating GVL and GVHD.
authors.affiliation: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI.
authors.forename: James
authors.identifier: http://orcid.org/0000-0001-8595-3940
authors.initials: J
authors.lastname: Ferrara
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology*; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology*; D020544:Graft vs Leukemia Effect; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D058504:Th17 Cells / Q000473:pathology*
chemical_list: D020381:Interleukin-17