title: Gene expression profiling of the inner ear.
abstract: The identification of transcriptional differences has served as an important starting point in understanding the molecular mechanisms behind biological processes and systems. The developmental biology of the inner ear, the biology of hearing and of course the pathology of deafness are all processes that warrant a molecular description if we are to improve human health. To this end, technological innovation has meant that larger scale analysis of gene transcription has been possible for a number of years now, extending our molecular analysis of genes to beyond those that are currently in vogue for a given system. In this review, some of the contributions gene profiling has made to understanding developmental, pathological and physiological processes in the inner ear are highlighted.
authors.affiliation: Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Científicas, Valladolid, Spain.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schimmang
authors.affiliation: School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Maconochie
mesh_terms: D000818:Animals; D003638:Deafness / Q000235:genetics; D007758:Ear, Inner / Q000196:embryology / Q000502:physiology*; D020869:Gene Expression Profiling / Q000379:methods; D006309:Hearing / Q000235:genetics / Q000502:physiology; D006801:Humans; D046228:Microarray Analysis
keywords: deafness; hearing; transcription