title: Mapping of Genetic Factors That Elicit Intermale Aggressive Behavior on Mouse Chromosome 15: Intruder Effects and the Complex Genetic Basis.
abstract: Despite high estimates of the heritability of aggressiveness, the genetic basis for individual differences in aggression remains unclear. Previously, we showed that the wild-derived mouse strain MSM/Ms (MSM) exhibits highly aggressive behaviors, and identified chromosome 15 (Chr 15) as the location of one of the genetic factors behind this escalated aggression by using a panel of consomic strains of MSM in a C57BL/6J (B6) background. To understand the genetic effect of Chr 15 derived from MSM in detail, this study examined the aggressive behavior of a Chr 15 consomic strain towards different types of opponent. Our results showed that both resident and intruder animals had to have the same MSM Chr 15 genotype in order for attack bites to increase and attack latency to be reduced, whereas there was an intruder effect of MSM Chr 15 on tail rattle behavior. To narrow down the region that contains the genetic loci involved in the aggression-eliciting effects on Chr 15, we established a panel of subconsomic strains of MSM Chr 15. Analysis of these strains suggested the existence of multiple genes that enhance and suppress aggressive behavior on Chr 15, and these loci interact in a complex way. Regression analysis successfully identified four genetic loci on Chr 15 that influence attack latency, and one genetic locus that partially elicits aggressive behaviors was narrowed down to a 4.1-Mbp region (from 68.40 Mb to 72.50 Mb) on Chr 15.
authors.affiliation: Mouse Genomics Resource Laboratory, National Institute of Genetics (NIG), Mishima, Shizuoka, Japan; Department of Genetics, SOKENDAI, Mishima, Shizuoka, Japan; Laboratory of Behavioral Neuroendocrinology, University of Tsukuba, Tsukuba, Ibaraki, Japan; Transdisciplinary Research Integration Center, Research Organization of Information and Systems, Minato-ku, Tokyo, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Mouse Genomics Resource Laboratory, National Institute of Genetics (NIG), Mishima, Shizuoka, Japan; Division of Biology, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugimoto
authors.affiliation: Transdisciplinary Research Integration Center, Research Organization of Information and Systems, Minato-ku, Tokyo, Japan; The Institute of Statistical Mathematics, Tachikawa, Tokyo, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Kato
authors.affiliation: Department of Genetics, SOKENDAI, Mishima, Shizuoka, Japan; Transdisciplinary Research Integration Center, Research Organization of Information and Systems, Minato-ku, Tokyo, Japan; Mammalian Genetics Laboratory, NIG, Mishima, Shizuoka, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shiroishi
authors.affiliation: Mouse Genomics Resource Laboratory, National Institute of Genetics (NIG), Mishima, Shizuoka, Japan; Department of Genetics, SOKENDAI, Mishima, Shizuoka, Japan; Transdisciplinary Research Integration Center, Research Organization of Information and Systems, Minato-ku, Tokyo, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Koide
mesh_terms: D000374:Aggression / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian; D056426:Genetic Loci; D006801:Humans; D008297:Male; D051379:Mice