title: Predictors of recurrence in the management of chordoid meningioma.
abstract: Management of chordoid meningiomas (CMs) is complicated by high rates of recurrence, particularly following subtotal resection. Optimal management is not established given the paucity of published experience. To identify prognostic factors for recurrence following resection, the authors conducted the largest systematic review of CMs to date. A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science utilizing the search terms "chordoid" AND "meningioma" was performed to identify all reports of pathologically confirmed intracranial CMs. A total of 221 patients were included, comprising 120 females and 101 males. Mean age, MIB-1/Ki67, and tumor size was 45.5 years, 4.3% (range 0.1-26.6%), and 4.1 cm (range 0.8-10 cm), respectively. 5-, and 10- year progression free survival was 67.5 and 54.4%, respectively. Gross total resection (GTR) and subtotal resection was achieved in 172 and 48 patients, respectively. Adjuvant radiotherapy (RT) was given to 30 patients. Multivariate analysis found GTR was strongly correlated with decreased recurrence rates (HR 0.04, p = <0.0001), while higher MIB-1 labeling index (≥5 vs <5%) was associated with increased recurrence (HR 7.08; p = 0.016). Adjuvant RT, age, gender, and tumor location were not associated with recurrence. GTR resection is the strongest predictor of tumor control, and should be the goal to minimize local progression. Additionally, higher MIB-1 labeling was associated with increased rates of tumor recurrence. Tumors that are subtotally resected or demonstrate higher MIB-1 are at greater recurrence and warrant consideration for RT and close long term follow up.
authors.affiliation: Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
authors.forename: Winward
authors.initials: W
authors.lastname: Choy
authors.affiliation: Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
authors.forename: Leonel
authors.initials: L
authors.lastname: Ampie
authors.affiliation: Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Lamano
authors.affiliation: Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
authors.forename: Kartik
authors.initials: K
authors.lastname: Kesavabhotla
authors.affiliation: Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Qinwen
authors.initials: Q
authors.lastname: Mao
authors.affiliation: Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Parsa
authors.affiliation: Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA. orin.bloch@northwestern.edu.
authors.forename: Orin
authors.initials: O
authors.lastname: Bloch
mesh_terms: D000328:Adult; D002829:Choroid / Q000473:pathology*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000628:therapy*; D008579:Meningioma / Q000628:therapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011237:Predictive Value of Tests; D016896:Treatment Outcome
keywords: Atypical; Chordoid; Meningioma; Radiation therapy; Surgery