title: Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography.
abstract: Clinical management of burn injuries depends upon an accurate assessment of the depth of the wound. Current diagnostic methods rely primarily on subjective visual inspection, which can produce variable results. In this study, spectroscopic optical coherence tomography was used to objectively evaluate burn injuries in vivo in a mouse model. Significant spectral differences were observed and correlated with the depth of the injury as determined by histopathology. The relevance of these results to clinical burn management in human tissues is discussed.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA ; These authors contributed equally to this work.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA ; These authors contributed equally to this work.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Maher
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, NC 27708, USA.
authors.forename: Jina
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC 27708, USA.
authors.forename: Maria Angelica
authors.initials: MA
authors.lastname: Selim
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, NC 27708, USA ; Department of Pathology, Duke University Medical Center, Durham, NC 27708, USA.
authors.forename: Howard
authors.initials: H
authors.lastname: Levinson
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Wax
keywords: (110.4500) Optical coherence tomography; (170.6510) Spectroscopy, tissue diagnostics