title: PPARα regulates tumor progression, foe or friend?
abstract: PPARα belongs to the peroxisome-proliferator-activated receptors (PPARs) family that consists of PPARα, PPARδ, and PAPRγ. Activation of PPARα by ligands including fatty acids and their derivatives as well as some synthetic compounds regulates tumor progression in various tissues. Activated PPARα inhibits or promotes tumorigenesis depending on the specific tissues, but the molecular mechanism is still unclear. In this review, the recent progress of PPARα regulating tumorigenesis is discussed.
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Jiaming
authors.initials: J
authors.lastname: Gao
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, PR China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 212017, PR China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Jin
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, PR China. Electronic address: sjj@ujs.edu.cn.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Shi
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, PR China; Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 212017, PR China. Electronic address: houyz@ujs.edu.cn.
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology; D005227:Fatty Acids / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D047493:PPAR alpha / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D005227:Fatty Acids; D008024:Ligands; D047493:PPAR alpha
keywords: Ligands; PPARα; Tumorigenesis