title: Endectocide activity of a pour-on formulation containing 1.5 per cent ivermectin +0.5 per cent abamectin in cattle.
abstract: The present work aimed to evaluate, through ten different studies, the therapeutic efficacy of a new pour-on formulation, containing 1.5 per cent ivermectin +0.5 per cent abamectin, against parasites of cattle. Results obtained on trials against Rhipicephalus (Boophilus) microplus showed that the pour-on combination of 1.5 per cent ivermectin +0.5 per cent abamectin obtained superior efficacy indexes against this ectoparasite, when compared with formulations containing 0.5 per cent ivermectin, 1 per cent ivermectin and the combination of 1 per cent abamectin +20 per cent levamisole. The results of efficacy of the ivermectin+abamectin and the 0.5 per cent ivermectin against Haematobia irritans were similar. Against Cochliomyia hominivorax larvae, all pour-on formulations tested (1.5 per cent ivermectin +0.5 per cent abamectin, 0.5 per cent ivermectin and 0.5 per cent abamectin), as well as 1 per cent doramectin administered subcutaneously, were considered ineffective. Cattle medicated with 1.5 per cent ivermectin +0.5 per cent abamectin, pour-on, remained free from parasitism by Dermatobia hominis larvae during 42 days (96 per cent efficacy), while values superior to 90 per cent were obtained by 0.5 per cent ivermectin (92 per cent) and 0.5 per cent abamectin (93 per cent) until the 42nd and 35th days post treatment, respectively. Against Haemonchus placei and Oesophagostomum radiatum, the pour-on of ivermectin+abamectin showed better efficacy than the 0.5 per cent ivermectin and 0.5 per cent abamectin. As to Cooperia punctata, there was no difference regarding efficacy results obtained by the avermectins combination and abamectin. The pour-on combination of 1.5 per cent ivermectin +0.5 per cent abamectin obtained high efficacy against R. (B.) microplus, D. hominis and some species of cattle gastrointestinal helminths when compared with formulations of 0.5 per cent ivermectin and 0.5 per cent abamectin administered through the same route.
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil ; Department of Veterinary Medicine, Instituto de Ciência da Saúde da Universidade Federal da Bahia Salvador-Bahia, Brazil.
authors.forename: Heloisa Cristina
authors.initials: HC
authors.lastname: Silva
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil ; Departament of Veterinary Medicine, Universidade Federal da Paraíba - Campus II, Brazil.
authors.forename: Nancy
authors.initials: N
authors.lastname: Prette
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil ; Department of Veterinary Medicine, Universidade Federal de Goiás - Regional de Jataí Jataí, GO, Brazil.
authors.forename: Welber Daniel Zanetti
authors.initials: WD
authors.lastname: Lopes
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil.
authors.forename: Cláudio Alessandro M
authors.initials: CA
authors.lastname: Sakamoto
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Buzzulini
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil.
authors.forename: Thais Rabelo
authors.initials: TR
authors.lastname: Dos Santos
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil.
authors.forename: Breno Cayeiro
authors.initials: BC
authors.lastname: Cruz
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil.
authors.forename: Weslen F Pires
authors.initials: WF
authors.lastname: Teixeira
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Felippelli
authors.affiliation: Department of Veterinary Medicine, Universidade Estadual de Maringá, Campus de Umuarama, Umuarama-Paraná, Brazil.
authors.forename: Rafael Silveira
authors.initials: RS
authors.lastname: Carvalho
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil.
authors.forename: Willian Giquelin
authors.initials: WG
authors.lastname: Maciel
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil.
authors.forename: Vando Edésio
authors.initials: VE
authors.lastname: Soares
authors.affiliation: Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil.
authors.forename: Alvimar José
authors.initials: AJ
authors.lastname: da Costa
keywords: Cattle; Dermatobia hominis; abamectin; ivermectin