title: Metastatic area ratio can help predict nonsentinel node positivity in melanoma patients.
abstract: Several studies suggest that melanoma patients with a positive sentinel node biopsy (SNB) can avoid having complete nodal dissection on the basis of pathological features of the node. The aim of the study was to determine the value of metastatic area ratio as a predictive factor for nonsentinel node (NSN) positivity. A retrospective analysis was carried out of melanoma patients who underwent SNB in a single institution between 2000 and 2010. A total of 697 patients were evaluated. In 155 patients (22.2%), the SNB was positive; 146 lymphadenectomies were performed, and 23 patients in whom this was performed (15.8%) had positive NSN. In multivariate analyses, Breslow thickness of more than 2 mm, perinodal vascular invasion, and metastatic area ratio were significantly related to NSN positivity in the complete nodal dissection. Metastatic area ratio of a positive SNB can be valuable in predicting the risk of NSN positivity.
authors.affiliation: Departments of aSkin Cancer bPathology cInternational Center for Research, AC Camargo Cancer Center, São Paulo, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bertolli
authors.forename: Mariana Petaccia de
authors.initials: MP
authors.lastname: Macedo
authors.forename: Clovis Antonio Lopes
authors.initials: CA
authors.lastname: Pinto
authors.forename: Aline Santos
authors.initials: AS
authors.lastname: Damascena
authors.forename: André Sapata
authors.initials: AS
authors.lastname: Molina
authors.forename: João Pedreira
authors.initials: JP
authors.lastname: Duprat Neto
mesh_terms: D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery