title: Experimental Study of the Mechanisms of Intracellular Defense in Cardiomyocytes Associated with Stages of Anthracosilicosis Development.
abstract: Mechanisms of intracellular defense of rat cardiomyocytes were studied in dynamics of anthracosilicosis development induced by long-term inhalation of coal and rock dust. It was shown that synthesis of transcription factor HIF-1α and protective proteins increased in the heart at the early stages of coal and rock dust inhalation (1-3 weeks), and these changes limited the development of free radical oxidation and activated metabolism of glucose and fatty acids. Exposure to coal and rock dust for 6-12 weeks activated free radical oxidation and decreased basal metabolism in cardiomyocytes.
authors.affiliation: Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Zakharenkov
authors.affiliation: Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Mikhailova
authors.affiliation: Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Zhdanova
authors.affiliation: Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia.
authors.forename: L G
authors.initials: LG
authors.lastname: Gorokhova
authors.affiliation: Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia. nyura_g@mail.ru.
authors.forename: A G
authors.initials: AG
authors.lastname: Zhukova
mesh_terms: D000818:Animals; D000874:Anthracosilicosis / Q000473:pathology*; D050884:HSP72 Heat-Shock Proteins / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism*; D010084:Oxidation-Reduction; D065840:Protective Factors; D017208:Rats, Wistar
chemical_list: D050884:HSP72 Heat-Shock Proteins; C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D006419:Heme Oxygenase (Decyclizing); C105245:heme oxygenase-2
keywords: HIF-1α; HSP family proteins; anthracosilicosis; free radical oxidation; myocardium