title: Lysophosphatidic acid signaling in ovarian cancer.
abstract: Lysophosphatidic acid (LPA) is a bioactive phospholipid that is involved in signal transduction between cells. Plasma and ascites levels of LPA are increased in ovarian cancer patients even in the early stages and thus LPA is considered as a potential diagnostic marker for this disease. This review presents the current knowledge regarding LPA signaling in epithelial ovarian cancer. LPA stimulates proliferation, migration and invasion of ovarian cancer cells through regulation of vascular endothelial growth factor, matrix metalloproteinases, urokinase plasminogen activator, interleukin-6, interleukin-8, CXC motif chemokine ligand 12/CXC receptor 4, COX2, cyclin D1, Hippo-Yap and growth-regulated oncogene α concentrations. In this article, all of these targets and signal pathways involved in LPA influence are described.
authors.affiliation: a Department of Biochemistry and Medical Chemistry and.
authors.forename: Anna
authors.initials: A
authors.lastname: Jesionowska
authors.affiliation: b Department of Laboratory Diagnostics and Molecular Medicine , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Cecerska-Heryc
authors.affiliation: b Department of Laboratory Diagnostics and Molecular Medicine , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Matoszka
authors.affiliation: b Department of Laboratory Diagnostics and Molecular Medicine , Pomeranian Medical University , Szczecin , Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Dolegowska
mesh_terms: D005260:Female; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction
chemical_list: D008246:Lysophospholipids; C032881:lysophosphatidic acid
keywords: Lysophospholipids; ovarian epithelial cancer; ovarian neoplasm; signal transduction