title: RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications.
abstract: Accurate genetic information transfer is essential for life. As a key enzyme involved in the first step of gene expression, RNA polymerase II (Pol II) must maintain high transcriptional fidelity while it reads along DNA template and synthesizes RNA transcript in a stepwise manner during transcription elongation. DNA lesions or modifications may lead to significant changes in transcriptional fidelity or transcription elongation dynamics. In this review, we will summarize recent progress toward understanding the molecular basis of RNA Pol II transcriptional fidelity control and impacts of DNA lesions and modifications on Pol II transcription elongation.
authors.affiliation: a Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California San Diego , La Jolla , CA , USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.affiliation: a Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California San Diego , La Jolla , CA , USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: a Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California San Diego , La Jolla , CA , USA.
authors.forename: Jenny
authors.initials: J
authors.lastname: Chong
authors.affiliation: a Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California San Diego , La Jolla , CA , USA.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Shin
authors.affiliation: a Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California San Diego , La Jolla , CA , USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: a Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California San Diego , La Jolla , CA , USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D004249:DNA Damage; D044127:Epigenesis, Genetic; D006801:Humans; D008958:Models, Molecular; D016296:Mutagenesis; D012313:RNA / Q000737:chemistry / Q000235:genetics*; D012319:RNA Polymerase II / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D012313:RNA; D004247:DNA; D012319:RNA Polymerase II
keywords: Chemical biology; DNA damage; RNA polymerase II; computational biology; epigenetic DNA modifications; structural biology; transcription fidelity