title: Customizing Structure-Function Displacements in the Macula for Individual Differences.
abstract: OBJECTIVE
  In the macula, retinal ganglion cells (RGCs) are displaced from their receptive fields. We used optical coherence tomography (OCT) to customize displacements for individual eyes by taking into account macular shape parameters, and determined the likely effect of individual anatomical differences on structure-function mapping in the central visual field.
  
  
  METHODS
  Using the population average model of Drasdo et al. as a starting point, we altered the RGC count in that model based on the ratio of an individual's RGC layer plus inner plexiform layer thickness to the population average on a pointwise basis as a function of eccentricity from the fovea. For 20 adults (age, 24-33; median age, 28) with normal vision, we computed displacements with the original model and our customized approach. We report the variance in displacements among individuals and compare the effects of such displacements on structure-function mapping of the commonly used the 10-2 visual field pattern.
  
  
  RESULTS
  As expected, customizing the displacement using individual OCT data made only a small difference on average from the population-based values predicted by the Drasdo et al. model. However, the range between individuals was over 1° at many locations, and closer to 2° at some locations in the superior visual field.
  
  
  CONCLUSIONS
  Individualizing macular displacement measurements based on OCT data for an individual can result in large spatial shifts in the retinal area corresponding to 10-2 locations, which may be important for clinical structure-function analysis when performed on a local, spatial scale.
authors.affiliation: Department of Computing and Information Systems The University of Melbourne, Melbourne, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Turpin
authors.affiliation: Department of Computing and Information Systems The University of Melbourne, Melbourne, Australia.
authors.forename: Siyuan
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Sepulveda
authors.affiliation: Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia.
authors.forename: Allison M
authors.initials: AM
authors.lastname: McKendrick
mesh_terms: D000328:Adult; D003198:Computer Simulation; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008266:Macula Lutea / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014794:Visual Fields; D055815:Young Adult