title: Protective effect of the orientin on noise-induced cognitive impairments in mice.
abstract: There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noise-induced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapse-associated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline.
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
authors.forename: Shuting
authors.initials: S
authors.lastname: Wang
authors.affiliation: Schizophrenia Research Institute (SRI), 405 Liverpool St., Sydney, NSW 2010, Australia; Illawarra Health and Medical Research Institute, School of Medicine, University of Wollongong, NSW 2522, Australia.
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zou
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
authors.forename: Yuyun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Schizophrenia Research Institute (SRI), 405 Liverpool St., Sydney, NSW 2010, Australia; Illawarra Health and Medical Research Institute, School of Medicine, University of Wollongong, NSW 2522, Australia.
authors.forename: Xu-Feng
authors.initials: XF
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: fugle99@126.com.
authors.forename: Yufu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: cbpeliuyinew@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D005960:Glucosides / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D051379:Mice; D009473:Neuronal Plasticity / Q000187:drug effects*; D009622:Noise; D018384:Oxidative Stress / Q000187:drug effects*; D017397:Prefrontal Cortex / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D005419:Flavonoids; D005960:Glucosides; C065886:orientin
keywords: Cognitive impairments; Orientin; Oxidative stress; Synaptic-associated plasticity