title: A New Predictive Tool for Optimization of the Treatment of Brain Metastases from Colorectal Cancer After Stereotactic Radiosurgery.
abstract: OBJECTIVE
  To develop a predictive tool for survival after stereotactic radiosurgery of brain metastases from colorectal cancer.
  
  
  METHODS
  Out of nine factors analyzed for survival, those showing significance (p<0.05) or a trend (p≤0.06) were included. For each factor, 0 (worse survival) or 1 (better survival) point was assigned. Total scores represented the sum of the factor scores.
  
  
  RESULTS
  Performance status (p=0.010) and interval from diagnosis of colorectal cancer until radiosurgery (p=0.026) achieved significance, extracranial metastases showed a trend (p=0.06). These factors were included in the tool. Total scores were 0-3 points. Six-month survival rates were 17% for patients with 0, 25% for those with 1, 67% for those with 2 and 100% for those with 3 points; 12-month rates were 0%, 0%, 33% and 67%, respectively. Two groups were created: 0-1 and 2-3 points. Six- and 12-month survival rates were 20% vs. 78% and 0% vs. 44% (p=0.002), respectively.
  
  
  CONCLUSIONS
  This tool helps optimize the treatment of patients after stereotactic radiosurgery for brain metastases from colorectal cancer.
authors.affiliation: Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
authors.forename: Dirk
authors.initials: D
authors.lastname: Rades
authors.affiliation: Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Dahlke
authors.affiliation: Department of Medical Oncology and Hematology, University of Lübeck, Lübeck, Germany.
authors.forename: Niklas
authors.initials: N
authors.lastname: Gebauer
authors.affiliation: Department of Medical Oncology and Hematology, University of Lübeck, Lübeck, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Bartscht
authors.affiliation: Department of Radiation Oncology, University Medical Center Eppendorf, Hamburg, Germany.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Hornung
authors.affiliation: Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam.
authors.forename: Ngo Thuy
authors.initials: NT
authors.lastname: Trang
authors.affiliation: Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam.
authors.forename: Pham Cam
authors.initials: PC
authors.lastname: Phuong
authors.affiliation: Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam Department of Nuclear Medicine, Hanoi Medical University, Hanoi, Vietnam.
authors.forename: Mai Trong
authors.initials: MT
authors.lastname: Khoa
authors.affiliation: Department of Neurosurgery, University of Lübeck, Lübeck, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Gliemroth
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D016371:Cranial Irradiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D016634:Radiosurgery / Q000401:mortality* / Q000592:standards*; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Colorectal cancer; cerebral oligo-metastases; predictive tool; stereotactic radiosurgery; survival; treatment optimization