title: The association between COMT Val158Met gene polymorphism and antipsychotic-induced tardive dyskinesia risk.
abstract: OBJECTIVE
  Catechol-O-methyltransferase (COMT) Val158Met gene polymorphism has been implicated the association with Tardive dyskinesia (TD) risk. However, lots of studies have reported contradictory results, so we conducted a meta-analysis to investigate the association between the COMT Val158Met gene polymorphism and TD susceptibility.
  
  
  METHODS
  The PubMed, Embase, China National Knowledge Internet and Wanfang Database were researched up to 5 January 2015. The odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the relationship, and the statistical analyses were carried out by STATA 11.0 software.
  
  
  RESULTS
  In total, 1206 cases and 1680 controls from 11 case-control studies were included in the present study. The overall and subgroup pooled results indicated no significant association between COMT Val158Met gene polymorphism and TD susceptibility in all gene models (AA + AG vs.
  0.98, 95% CI = 0.76-1.26, P = 0.87; AA vs. AG +
  1.15, 95% CI = 0.93-1.42, P = 0.271; AA vs.
  1.15, 95% CI = 0.90-1.49, P = 0.27; AG vs.
  0.95, 95% CI = 0.80-1.14, P = 0.59; A vs.
  1.05, 95% CI = 0.93-1.17, P = 0.43).
  
  
  CONCLUSIONS
  The study suggested COMT Val158Met gene polymorphism may not be an independent risk factor for TD susceptibility, especially in East Asians.
authors.affiliation: a 1 Neurology Department , The Affiliated Hospital of Luzhou Medical College , Luzhou , China.|b 2 Neurology Department, West China Hospital/West China School of Medicine , Sichuan University , Chengdu , China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Lv
authors.affiliation: a 1 Neurology Department , The Affiliated Hospital of Luzhou Medical College , Luzhou , China.
authors.forename: Benbing
authors.initials: B
authors.lastname: Rong
authors.affiliation: b 2 Neurology Department, West China Hospital/West China School of Medicine , Sichuan University , Chengdu , China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Tong
authors.affiliation: a 1 Neurology Department , The Affiliated Hospital of Luzhou Medical College , Luzhou , China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Li
authors.affiliation: a 1 Neurology Department , The Affiliated Hospital of Luzhou Medical College , Luzhou , China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Chen
authors.affiliation: a 1 Neurology Department , The Affiliated Hospital of Luzhou Medical College , Luzhou , China.
authors.forename: Xixi
authors.initials: X
authors.lastname: Wang
authors.affiliation: a 1 Neurology Department , The Affiliated Hospital of Luzhou Medical College , Luzhou , China.
authors.forename: Zuoxiao
authors.initials: Z
authors.lastname: Li
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D006801:Humans; D000071057:Tardive Dyskinesia / Q000139:chemically induced* / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: COMT; meta-analysis; susceptibility; tardive dyskinesia