title: Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils.
abstract: Lippia microphylla Cham. (Verbenaceae) is an endemic underexploited Brazilian vegetal. This work reviewed the biological potentialities of Lippia microphylla, emphasizing the properties of essential oils (EOs) and analyzed scientific indicators about genus Lippia and L. microphylla. Databases from 1948 to the present were searched and a software (vantage point 7.1) associated with Derwent Innovation Index was used to identify the indicators of the genus Lippia, and biological activities and compounds in the L. macrophylla species. Ethnopharmacological records report use of L. microphylla leaves to treat gastrointestinal disorders, influenza, bronchitis, cough, nasal congestion, and sinusitis during vaporization, whose aromatic volatile oils are rich in monoterpenes, especially cineole, terpineol, and thymol. Other EOs have larvicidal activity on Aedes aegypti larvae, and antifungal, antibacterial and cytotoxic and antitumor action on human and murine cancer cells. Brazil is the country with more articles about Lippia species, but it deposited only 9 patents since 1993. Most of the publications about L. microphylla are concentrated in food and chemical sciences. This bioprospection helps to choice areas of interest for capital investment and to give support for Brazilian Institutions to establish cooperation and improve technological impact at the point of view of creation and innovation.
authors.affiliation: Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil.
authors.forename: Evelyne Rolim Braun
authors.initials: ER
authors.lastname: Simões
authors.affiliation: Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil.
authors.forename: Evelyne Alves
authors.initials: EA
authors.lastname: Santos
authors.affiliation: Departamento de Ciências Biológicas, Campus Senador Helvídio Nunes de Barros, Universidade Federal do Piauí, Picos, Piauí, Brasil.
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: de Abreu
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina, Piauí, Brasil.
authors.forename: Jurandy do Nascimento
authors.initials: Jdo N
authors.lastname: Silva
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina, Piauí, Brasil.
authors.forename: Nárcia Mariana Fonseca
authors.initials: NM
authors.lastname: Nunes
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina, Piauí, Brasil.
authors.forename: Marcília Pinheiro
authors.initials: MP
authors.lastname: da Costa
authors.affiliation: Departamento de Química Orgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil.
authors.forename: Otília Deusdênia Loiola
authors.initials: OD
authors.lastname: Pessoa
authors.affiliation: Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil ; Fundação Oswaldo Cruz, Fortaleza, Ceará, Brasil.
authors.forename: Cláudia
authors.initials: C
authors.lastname: Pessoa
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina, Piauí, Brasil ; Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, Teresina, Piauí, Brasil.
authors.forename: Paulo Michel Pinheiro
authors.initials: PM
authors.lastname: Ferreira
keywords: Antitumor action; Lippia microphylla; pharmacological activity; scientific indicators; terpenes