title: Feasability of a new process to produce fast disintegrating pellets as novel multiparticulate dosage form for pediatric use.
abstract: Novel orally disintegrating system based on multiparticulate form was developed, offering an alternative to encounter major issues in the design of dosage form for pediatric patients, i.e., the difficulty in swallowing large solid dosage form (tablet or capsule), and the requirement to cover a broad range of doses for different age groups. Microcrystalline cellulose-based pellets containing acetaminophen were prepared via extrusion/spheronization followed by freeze-drying. The in vitro disintegration behavior of these pellets was quantitatively measured with a texture analyzer. Mercury intrusion and gas adsorption techniques, scanning electron microscopy of pellet surface and cross-section were performed in order to characterize their internal porous structure. Pellets characteristics such as size distribution, sphericity, friability and drug release were also determined. The developing process was able to produce pellets containing high drug loading (25, 50 and up to 75%, w/w) with good sphericity (aspect ratio ∼1) and low friability. The pellets exhibited an instantaneous disintegration upon contact with water, which was indicated by two parameters: the disintegration onset was approximating to 0, and the disintegration time less than 5s. The fast disintegration behavior is correlated with the pellet internal structure characterized by a capillary network with pore diameter varying from 0.1 to 10μm. Such a structure not only ensured a rapid disintegration but it also offers to freeze-dried pellets adequate mechanical properties in comparison with conventional freeze-dried forms. Due to pellet disintegration, fast dissolution of acetaminophen was achieved, i.e., more than 90% of drug released within 15min. This novel multiparticulate system offers novel age-appropriate dosage form for pediatric population owing to their facility of administration (fast disintegration) and dosing flexibility (divided and reduced-size solid form).
authors.affiliation: Univ. Lille, Inserm, CHU Lille, U 1008-Controlled Drug Delivery Systems and Biomaterials, F-5900 Lille, France.
authors.forename: Thanh Huong
authors.initials: TH
authors.lastname: Hoang Thi
authors.affiliation: Univ. Lille, Inserm, CHU Lille, U 1008-Controlled Drug Delivery Systems and Biomaterials, F-5900 Lille, France.
authors.forename: Siham
authors.initials: S
authors.lastname: Lhafidi
authors.affiliation: Laboratório de Desenvolvimento Galênico, Nanobiotecnologia e Tecnologia Farmacêutica, Universidade Federal de Ouro Preto, Morro do Cruzeiro, 35400-000 Ouro Preto, Brazil.
authors.forename: Simone Pinto
authors.initials: SP
authors.lastname: Carneiro
authors.affiliation: Univ. Lille, Inserm, CHU Lille, U 1008-Controlled Drug Delivery Systems and Biomaterials, F-5900 Lille, France; Univ. Lille, Faculté d'Ingénierie et Management de la Santé (ILIS), 42 rue Ambroise Paré, F-59120 Loos, France. Electronic address: marie-pierre.flament@univ-lille2.fr.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Flament
mesh_terms: D002482:Cellulose; D002648:Child; D004304:Dosage Forms; D005240:Feasibility Studies; D005612:Freeze Drying; D006801:Humans; D010316:Particle Size; D012995:Solubility; D013678:Technology, Pharmaceutical
chemical_list: D004304:Dosage Forms; D002482:Cellulose; C109691:microcrystalline cellulose
keywords: Extrusion/spheronization; Fast disintegration; Freeze-drying; Pediatric dosage form