title: Peripheral blood lymphocyte/monocyte ratio as a useful prognostic factor in dogs with diffuse large B-cell lymphoma receiving chemoimmunotherapy.
abstract: Diffuse large B-cell lymphoma (DLBCL) is the most frequent canine lymphoid neoplasm. Despite treatment, the majority of dogs with DLBCL experience tumour relapse and consequently die, so practical models to characterise dogs with a poor prognosis are needed. This study examined whether the lymphocyte/monocyte ratio (LMR) can predict outcome in dogs with newly diagnosed DLBCL with regard to time-to-progression (TTP) and lymphoma specific survival (LSS). A retrospective study analysed the prognostic significance of LMR obtained at diagnosis by flow cytometry (based on morphological properties and CD45 expression) in 51 dogs that underwent complete staging and received the same treatment, comprising multi-agent chemotherapy and administration of an autologous vaccine. Dogs with an LMR ≤ 1.2 (30% of all cases) were found to have significantly shorter TTP and LSS, and it was concluded that LMR was a useful independent prognostic indicator with biological relevance in dogs with DLBCL treated with chemoimmunotherapy.
authors.affiliation: Centro Oncologico Veterinario, via San Lorenzo 1-4, 40037 Sasso Marconi (BO), Italy. Electronic address: marconato@centroncologicovet.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Marconato
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, via Celoria 10, 20133 Milan, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Martini
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, via Celoria 10, 20133 Milan, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Stefanello
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, via Celoria 10, 20133 Milan, Italy.
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Moretti
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, via Celoria 10, 20133 Milan, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Ferrari
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, via Celoria 10, 20133 Milan, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Comazzi
authors.affiliation: Centro Oncologico Veterinario, via San Lorenzo 1-4, 40037 Sasso Marconi (BO), Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Laganga
authors.affiliation: Department of Veterinary Sciences, University of Turin, Largo Braccini 2, 10095 Gruglisco (TO), Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Riondato
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Agripolis Legnaro (PD), Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Aresu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D019496:Cancer Vaccines / Q000276:immunology*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D008214:Lymphocytes / Q000502:physiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D008297:Male; D009000:Monocytes / Q000502:physiology*; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D019496:Cancer Vaccines
keywords: Chemoimmunotherapy; Diffuse large B-cell lymphoma; Dog; Lymphocyte–monocyte ratio; Prognosis