title: Bilateral lower extremity hyperkeratotic plaques: a case report of ichthyosis vulgaris.
abstract: Here, we report a case of a middle-aged woman presenting with severe, long-standing, hyperkeratotic plaques of the lower extremities unrelieved by over-the-counter medications. Initial history and clinical findings were suggestive of an inherited ichthyosis. Ichthyoses are genetic disorders characterized by dry scaly skin and altered skin-barrier function. A diagnosis of ichthyosis vulgaris was confirmed by histopathology. Etiology, prevalence, and treatment options are discussed.
authors.affiliation: Department of Dermatology, West Virginia University, Morgantown, WV, USA.
authors.forename: Hayley
authors.initials: H
authors.lastname: Leight
authors.affiliation: Department of Dermatology, West Virginia University, Morgantown, WV, USA.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Zinn
authors.affiliation: Department of Dermatology, West Virginia University, Morgantown, WV, USA.
authors.forename: Omid
authors.initials: O
authors.lastname: Jalali
keywords: FLG; filaggrin gene; hyperkeratosis; keratohyalin granules; profilaggrin