title: Palladacycle promoted base controlled regio- and enantioselective hydrophosphination of 2-pyridylacrylate/amide and the cytotoxicity of their gold complexes.
abstract: The regioselective asymmetric hydrophosphination of pyridine-functionalized alkenes can be achieved in the presence of stoichiometric amounts of the chiral palladium complex (R)-1. The presence or absence of base affords the respective β- and α-adducts with excellent regiocontrol. Chiral gold-phosphine complexes incorporating the adducts exhibited good in vitro anticancer activity against the breast cancer cell line MDA-MB-231. Selectivity between the cancer cell line and normal cells was also observed.
authors.affiliation: Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616.
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: Jia
authors.forename: Renta
authors.initials: R
authors.lastname: Jonathan Chew
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Li
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Zhu
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Li
authors.forename: Sumod A
authors.initials: SA
authors.lastname: Pullarkat
authors.forename: Nguan
authors.initials: N
authors.lastname: Soon Tan
authors.forename: Pak-Hing
authors.initials: PH
authors.lastname: Leung
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D000475:Alkenes; D000577:Amides; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D010720:Phosphines; D010165:Palladium; D006046:Gold; C044646:phosphine; C036658:acrylic acid