title: Intrinsically disordered proteins: emerging interaction specialists.
abstract: Intrinsically disordered proteins or regions of proteins (IDPs/IDRs) most often function through protein-protein interactions, when they permanently or transiently bind partner molecules with diverse functional consequences. There is a rapid advance in our understanding of the ensuing functional modes, obtained from describing atomic details of individual complexes, proteome-wide studies of interactomes and characterizing loosely assembled hydrogels and tightly packed amyloids. Here we briefly survey the most important recent methodological developments and structural-functional observations, with the aim of increasing the general appreciation of IDPs/IDRs as 'interaction specialists'.
authors.affiliation: VIB Structural Biology Research Center (SBRC), Brussels, Belgium; Vrije Universiteit Brussel, Brussels, Belgium; Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary. Electronic address: ptompa@vub.ac.be.
authors.forename: Peter
authors.initials: P
authors.lastname: Tompa
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Eva
authors.initials: E
authors.lastname: Schad
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Tantos
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Lajos
authors.initials: L
authors.lastname: Kalmar
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000737:chemistry / Q000378:metabolism*; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D025941:Protein Interaction Mapping; D011499:Protein Processing, Post-Translational
chemical_list: D064267:Intrinsically Disordered Proteins