title: Oligodendrocytes in a Nutshell.
abstract: Oligodendrocytes are the myelinating cells of the central nervous system (CNS). While the phrase is oft repeated and holds true, the last few years have borne witness to radical change in our understanding of this unique cell type. Once considered static glue, oligodendrocytes are now seen as plastic and adaptive, capable of reacting to a changing CNS. This review is intended as a primer and guide, exploring how the past 5 years have fundamentally altered our appreciation of oligodendrocyte development and CNS myelination.
authors.affiliation: Ottawa Hospital Research Institute , Ottawa, ON , Canada ; Department of Cellular and Molecular Medicine, University of Ottawa , Ottawa, ON , Canada.
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Michalski
authors.affiliation: Ottawa Hospital Research Institute , Ottawa, ON , Canada ; Department of Cellular and Molecular Medicine, University of Ottawa , Ottawa, ON , Canada ; Department of Medicine, University of Ottawa , Ottawa, ON , Canada ; Centre for Neuromuscular Disease, University of Ottawa , Ottawa, ON , Canada.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Kothary
keywords: OPC; actin; cytoskeleton; glial cell; microtubule; myelin; myelination