title: Development of anticancer agents targeting the Wnt/β-catenin signaling.
abstract: Wnt/β-catenin signaling plays indispensable roles in both embryonic development and adult homeostasis. Abnormal regulation of this pathway is implicated in many types of cancer. Consequently, substantial efforts have made to develop therapeutic agents as anticancer drugs by specifically targeting the Wnt/β-catenin pathway. Here we systematically review the potential therapeutic agents that have been developed to date for inhibition of the Wnt/β-catenin cascade as well as current status of clinical trials of some of these agents.
authors.affiliation: College of Life Science, Yan'an University Yan'an 716000, Shaanxi, China.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA ; Graduate College of Biomedical Sciences, Western University of Health Sciences Pomona, CA, 91766, USA.
authors.forename: Jijun
authors.initials: J
authors.lastname: Hao
keywords: Wnt/β-catenin signaling; biologic agents; cancer; safety and clinic; small molecules; therapeutic; β-catenin