title: Acute Hepatitis E-Associated Acute Pancreatitis: A Single Center Experience and Literature Review.
abstract: OBJECTIVE
  Because acute pancreatitis (AP) associated with acute hepatitis E is rarely reported, we present such a case series.
  
  
  METHODS
  Records of patients admitted with AP to our institution between May 2007 and December 2013 were reviewed. Diagnosis of AP and acute hepatitis E was based on high serum amylase and/or lipase (>3 times the upper normal limit) and abdominal imaging and presence of serum IgM antibodies against hepatitis E virus, respectively. Other causes of AP were excluded by appropriate evaluation.
  
  
  RESULTS
  Of 790 patients with AP, 16 (2.1%; median [range] age, 25 [16-54] years; 15 males) had hepatitis E and no other cause of AP; coexistent hepatitis A and B were present in two and one of them, respectively. Acute pancreatitis began (median [range], 8 [0-35] days) after acute hepatitis and was mild in 10 and severe in 6. Complications included intra-abdominal collections (5), acute renal failure (4), and acute lung injury (2). Median (range) bilirubin, alanine aminotransferase, and prothrombin time were 9.8 (0.4-25) mg/dL, 822 (54-4009) IU/L, 14.6 (9.7-27.4) seconds, respectively. Acute liver failure occurred in 1 patient only. No patient needed surgical, endoscopic, or percutaneous intervention.
  
  
  CONCLUSIONS
  Acute pancreatitis associated with hepatitis E is not uncommon and usually has good prognosis.
authors.affiliation: From the Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: Mithun
authors.initials: M
authors.lastname: Raj
authors.forename: Kundan
authors.initials: K
authors.lastname: Kumar
authors.forename: Uday C
authors.initials: UC
authors.lastname: Ghoshal
authors.forename: Vivek A
authors.initials: VA
authors.lastname: Saraswat
authors.forename: Rakesh
authors.initials: R
authors.lastname: Aggarwal
authors.forename: Samir
authors.initials: S
authors.lastname: Mohindra
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis; D055371:Acute Lung Injury / Q000150:complications / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000681:Amylases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D005260:Female; D006506:Hepatitis A / Q000150:complications / Q000175:diagnosis; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis; D016751:Hepatitis E / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D011379:Prognosis; D011517:Prothrombin Time; D012196:Review Literature as Topic; D055815:Young Adult
chemical_list: D000410:Alanine Transaminase; D008049:Lipase; D000681:Amylases; D001663:Bilirubin