title: Hyperparathyroidism Associated with Long-Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults.
abstract: OBJECTIVE
  To measure the effect of proton pump inhibitors (PPIs), with and without concurrent bisphosphonates, on parathyroid hormone (PTH), vitamin D, and calcium.
  
  
  METHODS
  Retrospective chart review of individuals 60 years and older. Subjects with reduced renal function (creatinine >1.3 mg/dL) and low vitamin D (<30 ng/mL) were excluded.
  
  
  METHODS
  Academic geriatric outpatient center in southern midwest.
  
  
  METHODS
  Individuals aged 60 and older with concurrent calcium, PTH, vitamin D, and creatinine laboratory measurements (N = 80) meeting labeled criteria.
  
  
  METHODS
  Serum calcium, PTH, vitamin D, and creatinine.
  
  
  RESULTS
  Chronic PPI exposure was associated with statistically significantly higher PTH (65.5 vs 30.3 pg/mL, P < .001; normal range 10-55 pg/mL) and lower calcium (9.1 vs 9.4 mg/dL, P = .02; normal range 8.5-10.5 mg/dL) than no PPI exposure. Chronic PPI exposure with concurrent BP therapy was associated with statistically significantly higher PTH (65.2 vs 43.4 pg/mL, P = .05) and lower calcium (9.2 vs 9.6 mg/dL, P = .04) than BP therapy only.
  
  
  CONCLUSIONS
  Based on the present study, chronic PPI exposure in elderly adults is associated with mild hyperparathyroidism regardless of concurrent oral BP administration.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.|Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Hinson
authors.affiliation: Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Bekka M
authors.initials: BM
authors.lastname: Wilkerson
authors.affiliation: Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Ivy
authors.initials: I
authors.lastname: Rothman-Fitts
authors.affiliation: Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Ann T
authors.initials: AT
authors.lastname: Riggs
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Brendan C
authors.initials: BC
authors.lastname: Stack
authors.affiliation: Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Donald L
authors.initials: DL
authors.lastname: Bodenner
mesh_terms: D000368:Aged; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D006961:Hyperparathyroidism / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D012189:Retrospective Studies; D014807:Vitamin D / Q000097:blood
chemical_list: D004164:Diphosphonates; D010281:Parathyroid Hormone; D054328:Proton Pump Inhibitors; D014807:Vitamin D; D003404:Creatinine; D002118:Calcium
keywords: PPIs; bisphosphonates; elderly; fracture; hyperparathyroidism