title: Nodal Langerhans cell histiocytosis with prominent eosinophilic emperipolesis.
abstract: Multinucleated giant cells of osteoclastic type are known to occur in nodal and extranodal lesions of Langerhans cell histiocytosis (LCH). These giant cells are thought to be derived from phagocytic histiocytes, which correlate with the degree of necrosis in LCH lesions. Emperipolesis commonly seen in Rosai-Dorfman disease is a distinct phenomenon characterized by intact phagocytosed cells in an intracytoplasmic vacuole protected from proteolytic digestion. We present a case of emperipolesis of inflammatory cells especially of eosinophils by multinucleated giant cells of Langhans type in a lymph node involved by LCH--a finding that has not been described previously in the literature.
authors.affiliation: Department of Cytology and Gynaec Pathology, Advanced Paediatric Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Chougule
authors.affiliation: Department of Cytology and Gynaec Pathology, Advanced Paediatric Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Shreya
authors.initials: S
authors.lastname: Srivastava
authors.affiliation: Division of Paediatric Hemato-Oncology, Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Sidharth
authors.initials: S
authors.lastname: Totadri
authors.affiliation: Department of Cytology and Gynaec Pathology, Advanced Paediatric Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Radhika
authors.initials: R
authors.lastname: Srinivasan
authors.affiliation: Division of Paediatric Hemato-Oncology, Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Trehan
mesh_terms: D057687:Emperipolesis; D004804:Eosinophils / Q000473:pathology*; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male
keywords: Langerhans cell histiocytosis; cytology; emperipolesis; lymph node