title: Soluble and Endogenous Secretory Receptors for Advanced Glycation End Products in Threatened Preterm Labor and Preterm Premature Rupture of Fetal Membranes.
abstract: The aim of the study was to compare sRAGE and esRAGE plasma levels in pregnant women with (A) threatened premature labor (n = 41), (B) preterm premature rupture of membranes (n = 49), and (C) preterm rupture of membranes at term (n = 48). The relationship between these and classic intrauterine infection markers and the latent time from symptoms up to delivery depending on RAGE's concentration were investigated. In groups A and B, a positive correlation was found between plasma sRAGE and latent time (r = 0,422; p = 0,001; r = 0,413, p = 0,004, resp.). High prognostic values were found in both groups for plasma sRAGE concentration and the latent time from symptoms up to delivery. Groups B and C presented higher levels of esRAGE than group A (526,315 ± 129,453 pg/mL and 576,212 ± 136,237 pg/mL versus 485,918 ± 133,127 pg/mL, p< 0,05). The conclusion is that sRAGE concentration can be a favorable prognostic factor in the presence of symptoms of threatened premature labor. Higher esRAGE plasma level in case of the rupture of membranes in mature and premature pregnancy suggests its participation in fetal membranes destruction.
authors.affiliation: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Rzepka
authors.affiliation: Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Dołegowska
authors.affiliation: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Rajewska
authors.affiliation: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kwiatkowski
authors.affiliation: Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland.
authors.forename: Daria
authors.initials: D
authors.lastname: Sałata
authors.affiliation: Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Budkowska
authors.affiliation: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland.
authors.forename: Leszek
authors.initials: L
authors.lastname: Domański
authors.affiliation: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland.
authors.forename: Wioletta
authors.initials: W
authors.lastname: Mikołajek-Bedner
authors.affiliation: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Torbé
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007752:Obstetric Labor, Premature / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D011247:Pregnancy; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: C000593871:AGER protein, human; D000067759:Receptor for Advanced Glycation End Products