title: Cerebrospinal fluid Coccidioides antigen testing in the diagnosis and management of central nervous system coccidioidomycosis.
abstract: The goal of this study was to report on the potential utility of cerebrospinal fluid (CSF) Coccidioides antigen testing in the diagnosis and management of Coccidioides meningitis. We retrospectively reviewed medical records of seven patients with Coccidioides meningitis who had Coccidioides antigen tests performed on CSF. In two severely immunocompromised patients, CSF Coccidioides antigen testing was helpful in the diagnosis when other testing modalities were negative. Coccidioides antigen testing was also useful in the management of patients who had progression of disease due to non-adherence, development of resistance, failure of therapy and the presence of vasculitis. Changing antigen levels helped identify disease complications in three patients that led to alterations in therapy or management. On the basis of our review of these seven patients with Coccidioides meningitis, we concluded that the Coccidioides antigen test contributed to the diagnosis and management of patients with Coccidioides meningitis.
authors.affiliation: University of Missouri-Kansas City, Kansas City, MO, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Bamberger
authors.affiliation: University of Missouri-Kansas City, Kansas City, MO, USA.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Pepito
authors.affiliation: Rush University School of Medicine, Chicago, IL, USA.
authors.forename: Laurie A
authors.initials: LA
authors.lastname: Proia
authors.affiliation: University of Texas-Houston, Houston, TX, USA.
authors.forename: Luis
authors.initials: L
authors.lastname: Ostrosky-Zeichner
authors.affiliation: University of Texas-Houston, Houston, TX, USA.
authors.forename: Madiha
authors.initials: M
authors.lastname: Ashraf
authors.affiliation: Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
authors.forename: Francisco
authors.initials: F
authors.lastname: Marty
authors.affiliation: Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
authors.forename: Eileen
authors.initials: E
authors.lastname: Scully
authors.affiliation: MiraVista Diagnostics and MiraVista Technologies, Indianapolis, IN, USA.
authors.forename: L Joseph
authors.initials: LJ
authors.lastname: Wheat
mesh_terms: D000328:Adult; D000946:Antigens, Fungal / Q000032:analysis* / Q000134:cerebrospinal fluid*; D002490:Central Nervous System / Q000382:microbiology*; D003045:Coccidioides / Q000276:immunology / Q000472:pathogenicity; D003047:Coccidioidomycosis / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D007118:Immunoassay; D016867:Immunocompromised Host; D008297:Male; D016921:Meningitis, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000946:Antigens, Fungal
keywords: Coccidioides; antigen; cerebrospinal fluid; coccidioidomycosis; meningitis