title: Linezolid-Associated Thrombocytopenia in Children With Renal Impairment.
abstract: Impaired renal function has been associated with an increased risk of thrombocytopenia in adults receiving linezolid. Findings from this retrospective cohort demonstrate an association between thrombocytopenia and lower creatinine clearance in children receiving linezolid.
authors.affiliation: Department of Pharmacy, Lutheran Hospital, Fort Wayne, Indiana;
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Jones
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana; Department of Pharmacy, Riley Hospital for Children at Indiana University Health, Indianapolis; Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine, Indianapolis.
authors.forename: Kristen R
authors.initials: KR
authors.lastname: Nichols
authors.affiliation: Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine, Indianapolis.
authors.forename: Heather L
authors.initials: HL
authors.lastname: DeYoung
authors.affiliation: Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine, Indianapolis.
authors.forename: Elaine G
authors.initials: EG
authors.lastname: Cox
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana;
authors.forename: Chad A
authors.initials: CA
authors.lastname: Knoderer
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D000069349:Linezolid / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D008297:Male; D010976:Platelet Count; D051437:Renal Insufficiency / Q000139:chemically induced*; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D003404:Creatinine; D000069349:Linezolid
keywords: children; linezolid; pediatric; renal impairment; thrombocytopenia