title: Specific imaging of atherosclerotic plaque lipids with two-wavelength intravascular photoacoustics.
abstract: The lipid content in plaques is an important marker for identifying atherosclerotic lesions and disease states. Intravascular photoacoustic (IVPA) imaging can be used to visualize lipids in the artery. In this study, we further investigated lipid detection in the 1.7-µm spectral range. By exploiting the relative difference between the IVPA signal strengths at 1718 and 1734 nm, we could successfully detect and differentiate between the plaque lipids and peri-adventitial fat in human coronary arteries ex vivo. Our study demonstrates that IVPA imaging can positively identify atherosclerotic plaques using only two wavelengths, which could enable rapid data acquisition in vivo.
authors.affiliation: Department of Biomedical Engineering, Thorax Center, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, Thorax Center, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands ; Interuniversity Cardiology Institute of The Netherlands-Netherlands Heart Institute, PO Box 19258, 3501 DG Utrecht, The Netherlands ; Section Audiology, Department of Otolaryngology-Head and Neck Surgery, and EMGO Institute of Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Krista
authors.initials: K
authors.lastname: Jansen
authors.affiliation: Department of Biomedical Engineering, Thorax Center, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands ; Interuniversity Cardiology Institute of The Netherlands-Netherlands Heart Institute, PO Box 19258, 3501 DG Utrecht, The Netherlands ; Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands ; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, China.
authors.forename: Antonius F W
authors.initials: AF
authors.lastname: van der Steen
authors.affiliation: Department of Biomedical Engineering, Thorax Center, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
authors.forename: Gijs
authors.initials: G
authors.lastname: van Soest
keywords: (110.0110) Imaging systems; (110.5120) Photoacoustic imaging; (110.5125) Photoacoustics