title: NMDA Receptors of A5 Area in the Regulation of Blood Pressure and Respiratory Activity during Hypoxia in Rats.
abstract: In narcotized (40 mg/kg sodium ethaminal intraperitoneally) spontaneously breathing albino rats, experimental short-term hypoxia induced BP drop and increased phrenic nerve firing rate. Unilateral microinjection of a selective NMDA receptor blocker ketamine hydrochloride (50 nl; 4 mM) into A5 area did not affect BP and phrenic nerve fi ring rate. However, against the background of preliminary NMDA receptor blockage, hypoxia more markedly stimulated rhythmic activity of the respiratory center and hypotensive response. Unilateral microinjection of a selective blocker of non-NMDA receptors GAMS (50 nl; 4 mM) into A5 area did not change initial BP and phrenic nerve fi ring rate. The studied parameters in rats exposed to hypoxia after blockage of non-NMDA receptors in A5 area did not differ from the control levels. Thus, activity of the respiratory center and BP in rats during hypoxia is regulated by the structures in A5 area and NMDA glutamate receptors.
authors.affiliation: Department of Normal Physiology of the Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia.
authors.forename: V F
authors.initials: VF
authors.lastname: Pyatin
authors.affiliation: Department of Normal Physiology of the Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia. tatarnikov_vs@mail.ru.
authors.forename: V S
authors.initials: VS
authors.lastname: Tatarnikov
mesh_terms: D000200:Action Potentials; D000818:Animals; D001794:Blood Pressure; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D015687:Cell Hypoxia; D007649:Ketamine / Q000494:pharmacology; D010791:Phrenic Nerve / Q000502:physiology; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012119:Respiration
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine
keywords: A5 area; NMDA receptors; blood pressure; hypoxia; phrenic nerve