title: Relative Uptake Factor of Invasive Ductal Breast Cancer in Breast-specific Gamma Imaging as a Surrogate Parameter for Sub-typing.
abstract: OBJECTIVE
  The retrospective evaluation of correlations between semi-quantitative breast-specific gamma imaging (BSGI) and invasive ductal breast cancer (IDC) sub-types.
  
  
  METHODS
  The biopsy specimen of 50 histologically-proven IDCs were retrospectively evaluated concerning receptor status, human epidermal growth factor receptor 2 (HER2/Neu) status, Ki-67 level and classification into IDC sub-types. These results were compared to the relative uptake factor (RUF) in BSGI. Depending on RUF, we described four categories to outline the predictive value of RUF.
  
  
  RESULTS
  A total of 50 IDCs with a mean diameter of 20.36 mm were included. RUF differed reliably between luminal-A and non-luminal-A IDCs. RUF exceeding 6.5 pointed to non luminal A-carcinoma, with a specificity and positive predictive value of 100%. RUF of less than 2.6 was unlikely to be associated with a non-luminal A-carcinoma (negative predictive value: 76.5%). Comparable results were calculated for the correlation between RUF and the K-67 level.
  
  
  CONCLUSIONS
  RUF may help classify the sub-type of an IDC in addition to pathology.
authors.affiliation: Department of Radiology, Paracelsus Medical University Salzburg, Salzburg, Austria thomas.meissnitzer@gmail.com t.meissnitzer@salk.at.
authors.forename: Thomas
authors.initials: T
authors.lastname: Meissnitzer
authors.affiliation: Department of Radiology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Matthias Wolfgang
authors.initials: MW
authors.lastname: Meissnitzer
authors.affiliation: Department of Sociology and Cultural Science, University of Salzburg, Salzburg, Austria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Seymer
authors.affiliation: Department of Radiology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Klaus
authors.initials: K
authors.lastname: Hergan
authors.affiliation: Department of Pathology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Daniel
authors.initials: D
authors.lastname: Neureiter
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000145:classification* / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000145:classification* / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005720:Gamma Rays; D006801:Humans; D007124:Immunoenzyme Techniques; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D011877:Radionuclide Imaging / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor
keywords: Breast-specific gamma imaging; correlation of relative uptake factor and IDC sub-types; invasive ductal breast cancer (IDC) sub-types; relative uptake factor