title: Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation.
abstract: OBJECTIVE
  To evaluate the changes in lung function in the first year after single lung transplantation in patients with idiopathic pulmonary fibrosis (IPF).
  
  
  METHODS
  We retrospectively evaluated patients with IPF who underwent single lung transplantation between January of 2006 and December of 2012, reviewing the changes in the lung function occurring during the first year after the procedure.
  
  
  RESULTS
  Of the 218 patients undergoing lung transplantation during the study period, 79 (36.2%) had IPF. Of those 79 patients, 24 (30%) died, and 11 (14%) did not undergo spirometry at the end of the first year. Of the 44 patients included in the study, 29 (66%) were men. The mean age of the patients was 57 years. Before transplantation, mean FVC, FEV1, and FEV1/FVC ratio were 1.78 L (50% of predicted), 1.48 L (52% of predicted), and 83%, respectively. In the first month after transplantation, there was a mean increase of 12% in FVC (400 mL) and FEV1 (350 mL). In the third month after transplantation, there were additional increases, of 5% (170 mL) in FVC and 1% (50 mL) in FEV1. At the end of the first year, the functional improvement persisted, with a mean gain of 19% (620 mL) in FVC and 16% (430 mL) in FEV1.
  
  
  CONCLUSIONS
  Single lung transplantation in IPF patients who survive for at least one year provides significant and progressive benefits in lung function during the first year. This procedure is an important therapeutic alternative in the management of IPF.
authors.affiliation: Santa Casa de Porto Alegre, Porto Alegre, BR.
authors.forename: Adalberto Sperb
authors.initials: AS
authors.lastname: Rubin
authors.affiliation: Santa Casa de Porto Alegre, Porto Alegre, BR.
authors.forename: Douglas Zaione
authors.initials: DZ
authors.lastname: Nascimento
authors.affiliation: Santa Casa de Porto Alegre, Porto Alegre, BR.
authors.forename: Letícia
authors.initials: L
authors.lastname: Sanchez
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, BR.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Watte
authors.affiliation: Santa Casa de Porto Alegre, Porto Alegre, BR.
authors.forename: Arthur Rodrigo Ronconi
authors.initials: AR
authors.lastname: Holand
authors.affiliation: Santa Casa de Porto Alegre, Porto Alegre, BR.
authors.forename: Derrick Alexandre
authors.initials: DA
authors.lastname: Fassbind
authors.affiliation: Santa Casa de Porto Alegre, Porto Alegre, BR.
authors.forename: José Jesus
authors.initials: JJ
authors.lastname: Camargo
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery*; D016040:Lung Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014797:Vital Capacity / Q000502:physiology