title: Disease risk assessment by clinical immunology analyses in periparturient dairy cows.
abstract: A disease prediction system was investigated in a case-control study in the dry period of high-yielding dairy cows. Blood samples of 75 cows from 26 herds were collected before calving between -23 and -33 days (T1) and also between -2 and -6 days (T2) to investigate a panel of clinical immunology and chemistry parameters. Cows with abnormal serum lysozyme and interleukin-6 concentrations showed a greater disease prevalence until the 60th day in milk compared with non-responder cows (P<0.05 and lower at T1). Differences in disease prevalence were observed on the basis of T1 data, and also by combining the results at T1 and T2. The other laboratory parameters under study were not predictive of a disease risk. Results indicate that environmental stressors in the dry period may cause a negative imprinting of the innate immune response, underlying predisposition to later disease occurrence.
authors.affiliation: Laboratory of Cellular Immunology, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna, 25124 Brescia, Italy. Electronic address: massimo.amadori@izsler.it.
authors.forename: M
authors.initials: M
authors.lastname: Amadori
authors.affiliation: National Reference Centre for Animal Welfare, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna, 25124 Brescia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fusi
authors.affiliation: Laboratory of Cellular Immunology, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna, 25124 Brescia, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Bilato
authors.affiliation: National Reference Centre for Animal Welfare, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna, 25124 Brescia, Italy.
authors.forename: I L
authors.initials: IL
authors.lastname: Archetti
authors.affiliation: National Reference Centre for Animal Welfare, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna, 25124 Brescia, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Lorenzi
authors.affiliation: National Reference Centre for Animal Welfare, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna, 25124 Brescia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bertocchi
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000276:immunology*; D005260:Female; D007113:Immunity, Innate / Q000502:physiology*; D058725:Peripartum Period / Q000502:physiology*; D018570:Risk Assessment; D012307:Risk Factors
keywords: Disease; Interleukin-6; Lysozyme; Periparturient cow