title: The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review.
abstract: The story of high mobility group protein B1 (HMGB1) in cancer is complicated and the function of HMGB1 in different cancers is uncertain. This review aims to retrieve literature regarding HMGB1 from English electronic resources, analyze and summarize the role of the HMGB1 signaling pathway in hepatocellular carcinoma (HCC), and provide useful information for carcinogenesis and progression of HCC. Results showed that HMGB1 could induce cell proliferation, differentiation, cell death, angiogenesis, metastasis, inflammation, and enhance immunofunction in in vitro and in vivo HCC models. HMGB1 and its downstream receptors RAGE, TLRs and TREM-1 may be potential anticancer targets. In conclusion, HMGB1 plays an important role in oncogenesis and represents a novel therapeutic target, which deserves further study.
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. wangxb@hbmu.edu.cn.|Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China. wangxb@hbmu.edu.cn.
authors.forename: Xuanbin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. longchaoxiang@hbmu.edu.cn.|Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China. longchaoxiang@hbmu.edu.cn.
authors.forename: Longchao
authors.initials: L
authors.lastname: Xiang
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. hongliangli@hbmu.edu.cn.|Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China. hongliangli@hbmu.edu.cn.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Li
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. pingchen@hbmu.edu.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.affiliation: School of Chinese Medicine, the University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China. yfeng@hku.hk.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. zhangjx@hbmu.edu.cn.|Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China. zhangjx@hbmu.edu.cn.
authors.forename: Jingxuan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. nianyang@hbmu.edu.cn.|Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China. nianyang@hbmu.edu.cn.
authors.forename: Nian
authors.initials: N
authors.lastname: Yang
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. fangli@hbmu.edu.cn.|Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China. fangli@hbmu.edu.cn.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. yewang@hbmu.edu.cn.|Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China. yewang@hbmu.edu.cn.
authors.forename: Ye
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. zhangqiufang@hbmu.edu.cn.|Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, 30 South Renmin Road, Shiyan 442000, Hubei, China. zhangqiufang@hbmu.edu.cn.
authors.forename: Quifang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. fangli@hbmu.edu.cn.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China. fengjuncao@hbmu.edu.cn.
authors.forename: Fengjun
authors.initials: F
authors.lastname: Cao
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D049109:Cell Proliferation; D018450:Disease Progression; D024243:HMGB1 Protein / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D009362:Neoplasm Metastasis; D015398:Signal Transduction
chemical_list: D024243:HMGB1 Protein; C585491:HMGB1 protein, human
keywords: hepatocellular carcinoma; high mobility group protein B1; receptor for advanced glycation end product; toll-like receptor; triggering receptor expressed on myeloid cells-1