title: Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics.
abstract: Four anatomical patterns of hydrocephalus secondary to congenital Toxoplasma gondii infection were identified and characterized for infants enrolled in the National Collaborative Chicago-based Congenital Toxoplasmosis Study. Analysis of parasite serotype revealed that different anatomical patterns associate with Type-II vs Not-Exclusively Type-II strains (NE-II) (P = .035).
authors.affiliation: Department of Ophthalmology and Visual Science, The University of Chicago.
authors.forename: Samuel L
authors.initials: SL
authors.lastname: Hutson
authors.affiliation: Department of Ophthalmology and Visual Science, The University of Chicago.
authors.forename: Kelsey M
authors.initials: KM
authors.lastname: Wheeler
authors.affiliation: Northwestern University and Lurie Children's Hospital and Medical Center.
authors.forename: David
authors.initials: D
authors.lastname: McLone
authors.affiliation: Section of Neurosurgery, The University of Chicago.
authors.forename: David
authors.initials: D
authors.lastname: Frim
authors.affiliation: Department of Bioengineering, College of Engineering, College of Medicine, University of Illinois at Chicago.
authors.forename: Richard
authors.initials: R
authors.lastname: Penn
authors.affiliation: Northwestern University and Lurie Children's Hospital and Medical Center.
authors.forename: Charles N
authors.initials: CN
authors.lastname: Swisher
authors.affiliation: Department of Pediatrics, Rush University Medical Center, Chicago.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Heydemann
authors.affiliation: Department of Pediatrics, Rush University Medical Center, Chicago.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Boyer
authors.affiliation: Northwestern University and Lurie Children's Hospital and Medical Center.
authors.forename: A Gwendolyn
authors.initials: AG
authors.lastname: Noble
authors.affiliation: North Shore University Hospital, Evanston, Illinois.
authors.forename: Peter
authors.initials: P
authors.lastname: Rabiah
authors.affiliation: Department of Ophthalmology and Visual Science, The University of Chicago.
authors.forename: Shawn
authors.initials: S
authors.lastname: Withers
authors.affiliation: Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, California.
authors.forename: Jose G
authors.initials: JG
authors.lastname: Montoya
authors.affiliation: Department of Public Health Sciences, The University of Chicago, Illinois.
authors.forename: Kristen
authors.initials: K
authors.lastname: Wroblewski
authors.affiliation: Department of Public Health Sciences, The University of Chicago, Illinois.
authors.forename: Theodore
authors.initials: T
authors.lastname: Karrison
authors.affiliation: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Grigg
authors.affiliation: Department of Ophthalmology and Visual Science, The University of Chicago.
authors.forename: Rima
authors.initials: R
authors.lastname: McLeod
mesh_terms: D015331:Cohort Studies; D005838:Genotype; D006801:Humans; D006849:Hydrocephalus / Q000469:parasitology* / Q000473:pathology*; D065288:Serogroup; D014122:Toxoplasma / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D014125:Toxoplasmosis, Congenital / Q000150:complications*
keywords: Toxoplasma gondii; aqueductal obstruction; foraminal obstruction; hydrocephalus