title: The A-B-C for SORting APP.
abstract: This Editorial highlights a study by Hermey and colleagues in the current issue of Journal of Neurochemistry. In their study, the authors provide novel insights into single-nucleotide polymorphisms associated with Alzheimer's disease and linked to the SorCS1 gene, toward a better understanding of the interaction of sorting receptor proteins which physically interact with the amyloid-beta protein precursor (APP). SorCS1, sortilin-related VPS10 domain-containing receptor 1; SorLA, sortilin-related Receptor with A-type Repeats. Read the full article 'SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport' on page 60.
authors.affiliation: School of Biomedical Sciences, Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Coulson
authors.affiliation: The Lundbeck Foundation Research Center MIND, Danish Research Institute of Translational Neuroscience (DANDRITE) Nordic EMBL Partnership, Department of Biomedicine, Aarhus University, Aarhus, Denmark.
authors.forename: Olav M
authors.initials: OM
authors.lastname: Andersen
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics*; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D021381:Protein Transport / Q000235:genetics; D000099183:Sortilin
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D016564:Amyloid beta-Protein Precursor; D026901:Membrane Transport Proteins; D000099183:Sortilin