title: Expression of adhesion molecules, chemokines and matrix metallo- proteinases (MMPs) in viable and degenerating stage of Taenia solium metacestode in swine neurocysticercosis.
abstract: Neurocysticercosis (NCC) is a parasitic infection of central nervous system (CNS). Expression of adhesion molecules, chemokines and matrix metalloproteinases (MMPs) were investigated on brain tissues surrounding viable (n=15) and degenerating cysticerci (n=15) of Taenia solium in swine by real-time RT-PCR and ELISA. Gelatin gel zymography was performed for MMPs activity. ICAM-1 (intercellular adhesion molecule-1), E-selectin, MIP-1α (macrophage inflammatory protein-1α), Eotaxin-1 and RANTES (regulated on activation, normal T cell expressed and secreted) were associated with degenerating cysticerci (cysts). However, VCAM-1 (vascular cell adhesion molecule-1), MCP-1 (monocyte chemotactic protein-1), MMP-2 and MMP-9 were associated with both viable and degenerating cysts. In conclusion, viable and degenerating cysticerci have different immune molecule profiles and role of these molecules in disease pathogenesis needs to be investigated.
authors.affiliation: Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P. 226014, India.
authors.forename: Satyendra K
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P. 226014, India.
authors.forename: Aloukick K
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P. 226014, India. Electronic address: kashinprasad@gmail.com.
authors.forename: Kashi N
authors.initials: KN
authors.lastname: Prasad
authors.affiliation: Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P. 226014, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Singh
authors.affiliation: Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P. 226014, India.
authors.forename: Avinash
authors.initials: A
authors.lastname: Singh
authors.affiliation: Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P. 226014, India.
authors.forename: Ravi P
authors.initials: RP
authors.lastname: Rai
authors.affiliation: Department of Anaesthesia Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P. 226014, India.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Tripathi
authors.affiliation: Department of Radiodiagnosis Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P. 226014, India.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Gupta
authors.affiliation: Department of Pathology Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, U.P. 226010, India.
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Husain
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000469:parasitology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D018925:Chemokines / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*; D020019:Neurocysticercosis / Q000378:metabolism / Q000469:parasitology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology*; D041201:Taenia solium
chemical_list: D015815:Cell Adhesion Molecules; D018925:Chemokines; D020782:Matrix Metalloproteinases
keywords: Different stages; Immune response; Neurocysticercosis; Taenia solium cyst