title: HEPACAM inhibited the growth and migration of cancer cells in the progression of non-small cell lung cancer.
abstract: Hepatocyte cell adhesion molecule (HEPACAM), a member of immunoglobulin superfamily, is an adhesion molecule. Although dysregulation of several adhesion molecules has been implicated in the progression of non-small cell lung cancer (NSCLC), the expression profile and functions of HEPACAM in NSCLC remains unknown. In this study, it was found that the expression of HEPACAM was downregulated in NSCLC tissues. Forced expression of HEPACAM in NSCLC cells inhibited the growth and migration of the cancer cells, while knocking down the expression of HEPACAM promoted cell growth, migration, and metastasis. In the molecular mechanism study, HEPACAM was found to be a negative regulator of beta-catenin/TCF signaling. Taken together, this study revealed the suppressive roles of HEPACAM in NSCLC and restoring the function of HEPACAM in NSCLC might be a promising strategy for the therapy.
authors.affiliation: Department of Critical Care Medicine, Henan Provincial People's Hospital, Affiliated of Zhengzhou University, Zhengzhou, 450003, China.
authors.forename: Huanzhang
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Critical Care Medicine, Affiliated Yixing People's Hospital, Jiangsu University, Yixing, 214200, Jiangsu Province, China.
authors.forename: Yinjie
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu Province, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu Province, China.
authors.forename: Peihua
authors.initials: P
authors.lastname: Lu
authors.affiliation: Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu Province, China.
authors.forename: Tingyan
authors.initials: T
authors.lastname: Ruan
authors.affiliation: Department of Medical Oncology, Wujin People's Hospital Affiliated to Jiangsu University, 2 North Yongning Rd, Changzhou, 213002, Jiangsu Province, China. luwenbin0716@sina.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Lu
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000235:genetics; D018797:Cell Cycle Proteins; D002460:Cell Line; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D018450:Disease Progression; D015536:Down-Regulation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D057809:HEK293 Cells; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D011506:Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D051176:beta Catenin / Q000235:genetics
chemical_list: D015815:Cell Adhesion Molecules; D018797:Cell Cycle Proteins; C487620:HEPACAM protein, human; D011506:Proteins; D051176:beta Catenin
keywords: Beta-catenin/TCF; Cell growth and migration; HEPACAM; Non-small cell lung cancer