title: Peripheral Biomarker Candidates of Posttraumatic Stress Disorder.
abstract: There is high variability in the manifestation of physical and mental health problems following exposure to trauma and disaster. Although most people may show a range of acute symptoms in the aftermath of traumatic events, chronic and persistent mental disorders may not be developed in all individuals who were exposed to traumatic events. The most common long-term pathological consequence after trauma exposure is posttraumatic stress disorder (PTSD). However, comorbid conditions including depression, anxiety disorder, substance use-related problems, and a variety of other symptoms may frequently be observed in individuals with trauma exposure. Post-traumatic syndrome (PTS) is defined collectively as vast psychosocial problems that could be experienced in response to traumatic events. It is important to predict who will continue to suffer from physical and mental health problems and who will recover following trauma exposure. However, given the heterogeneity and variability in symptom manifestations, it is difficult to find identify biomarkers which predict the development of PTSD. In this review, we will summarize the results of recent studies with regard to putative biomarkers of PTSD and suggest future research directions for biomarker discovery for PTSD.
authors.affiliation: Ewha Brain Institute, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kang
authors.affiliation: Ewha Brain Institute, Ewha Womans University, Seoul 03760, Korea.
authors.forename: Sujung
authors.initials: S
authors.lastname: Yoon
authors.affiliation: Ewha Brain Institute, Ewha Womans University, Seoul 03760, Korea. ; Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul 03760, Korea. ; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
authors.forename: In Kyoon
authors.initials: IK
authors.lastname: Lyoo
keywords: biomarkers; inflammation; neuroendocrine system; neurotransmission; posttraumatic stress disorder (PTSD); posttraumatic syndrome (PTS)