title: Longevity and aging. Mechanisms and perspectives.
abstract: Longevity can mostly be determined with relative accuracy from birth and death registers when available. Aging is a multifactorial process, much more difficult to quantitate. Every measurable physiological function declines with specific speeds over a wide range. The mechanisms involved are also different, genetic factors are of importance for longevity determinations. The best-known genes involved are the Sirtuins, active at the genetic and epigenetic level. Aging is multifactorial, not "coded" in the genome. There are, however, a number of well-studied physical and biological parameters involved in aging, which can be determined and quantitated. We shall try to identify parameters affecting longevity as well as aging and suggest some reasonable predictions for the future.
authors.affiliation: Laboratoire de recherche ophtalmologique, hôpital Hôtel-Dieu, université Paris 5, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, France.
authors.forename: J
authors.initials: J
authors.lastname: Labat-Robert
authors.affiliation: Laboratoire de recherche ophtalmologique, hôpital Hôtel-Dieu, université Paris 5, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, France. Electronic address: lrobert5@orange.fr.
authors.forename: L
authors.initials: L
authors.lastname: Robert
mesh_terms: D000375:Aging / Q000235:genetics* / Q000473:pathology; D000818:Animals; D005602:France / Q000453:epidemiology; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000235:genetics*; D009026:Mortality / Q000266:history
keywords: Aging; Longevity; Longévité; Maillard reaction; Réaction de Maillard; Sirtuines; Sirtuins; Supercentenaires; Supercentenarians; Vieillissement