title: "Messieurs, c'est les microbes qui auront le dernier mot": Gentlemen, it is the microbes who have the last word (Louis Pasteur)-Fusobacterium nucleatumprotect tumors from killing by immune cells.
abstract: Fusobacterium nucleatumis present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.
authors.affiliation: The Lautenberg Center of General and Tumor Immunology; IMRIC; The Hebrew University Hadassah Medical School ; Jerusalem, Israel ; The Rheumatology Research Center; Hadassah-Hebrew University ; Jerusalem, Israel.
authors.forename: Chamutal
authors.initials: C
authors.lastname: Gur
authors.affiliation: The Lautenberg Center of General and Tumor Immunology; IMRIC; The Hebrew University Hadassah Medical School ; Jerusalem, Israel.
authors.forename: Ofer
authors.initials: O
authors.lastname: Mandelboim
authors.affiliation: The Institute of Dental Sciences; The Hebrew University-Hadassah School of Dental Medicine ; Jerusalem, Israel.
authors.forename: Gilad
authors.initials: G
authors.lastname: Bachrach
keywords: NK cells; colon adenocarcinoma; fusobacteria; tumor immunity