title: Recommendations for managing a suboptimal response to biologics for moderate-to-severe psoriasis: A Belgian perspective.
abstract: Over the past decade, biologics have become the gold standard in the treatment of moderate-to-severe psoriasis for patients who have failed or who have contraindications to traditional systemic treatments. However, although practical recommendations on how to treat a suboptimal response to biologics exist in other chronic inflammatory diseases, they are only just beginning to emerge for psoriasis. This article aims to formulate recommendations in the case of a suboptimal response of psoriasis to biologics in the Belgian setting. A Belgian taskforce of psoriasis experts was convened to review the results of a literature search and formulate recommendations based on the available evidence and provide expert opinion to address gaps in the evidence. The taskforce has proposed a treatment algorithm for patients with a primary non-response or a secondary loss of response to help address an unmet need. Expert recommendations have been developed to address treatment strategies in case of a primary or secondary suboptimal response to biologics in the treatment of moderate-to-severe psoriasis in Belgium.
authors.affiliation: a Department of Dermatology , Centre Hospitalier Universitaire de Liège , Liège , Belgium .
authors.forename: Michel
authors.initials: M
authors.lastname: de la Brassinne
authors.affiliation: b Department of Dermatology , Clinical Research, Cliniques Saint-Luc, Université Catholique de Louvain , Brussels , Belgium .
authors.forename: Pierre-Dominique
authors.initials: PD
authors.lastname: Ghislain
authors.affiliation: c Department of Dermatology , University of Ghent , Ghent , Belgium .
authors.forename: Jo L W
authors.initials: JL
authors.lastname: Lambert
authors.affiliation: d Department of Dermatology , University Hospital of Antwerp, University of Antwerp , Antwerp , Belgium .
authors.forename: Julien
authors.initials: J
authors.lastname: Lambert
authors.affiliation: e Department of Dermatology , University Hospitals Leuven , Leuven , Belgium , and.
authors.forename: Siegfried
authors.initials: S
authors.lastname: Segaert
authors.affiliation: f Department of Dermatology , Erasme University Hospital , Brussels , Belgium.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Willaert
mesh_terms: D001688:Biological Products / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D011565:Psoriasis / Q000628:therapy*
chemical_list: D001688:Biological Products
keywords: Algorithm; biologics; immunogenicity; psoriasis; secondary failure