title: Association of Salivary Helicobacter pylori Infection with Oral Diseases: a Cross-sectional Study in a Chinese Population.
abstract: OBJECTIVE
  The aim of this study was to detect the prevalence of oral H.pylori among adults and to investigate the correlation between H.pylori infection and common oral diseases.
  
  
  METHODS
  A cross-sectional study was performed among adults Chinese who took their annual oral healthy examination at The First Affiliated Hospital, Zhejiang University School of Medicine, China.
  
  
  RESULTS
  The study included 1050 subjects in total and oral H.pylori infection occurred in 60.29% of the subjects. The prevalence rates of oral H.pylori in patients with periodontal diseases (63.42%) and caries (66.91%) were significantly increased than those without oral diseases (54.07%), respectively (P < 0.05), while the difference between subjects with recurrent aphthous stomatitis and controls was not significant. In addition, the differences of positive rates of H.pylori with or without history of gastric ulcer were statistically significant (69.47% vs 58.26%, P<0.05). Presenting with periodontal diseases (OR 1.473;95% CI 1.021 to 2.124), caries (OR 1.717; 1.127 to 2.618), and having history of gastric ulcer (OR 1.631; 1.164 to 2.285) increased the risk of H.pylori infection.
  
  
  CONCLUSIONS
  Oral H.pylori infection is common in adult Chinese, which is significantly associated with oral diseases including periodontal diseases and caries.
authors.affiliation: 1. Department of Stomatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Yi-Jian
authors.initials: YJ
authors.lastname: Ding
authors.affiliation: 2. Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Tian-Lian
authors.initials: TL
authors.lastname: Yan
authors.affiliation: 3. Department of Stomatology, Red Corss Hospital, Hangzhou 310003, China.
authors.forename: Xin-Lan
authors.initials: XL
authors.lastname: Hu
authors.affiliation: 1. Department of Stomatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: 2. Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Chao-Hui
authors.initials: CH
authors.lastname: Yu
authors.affiliation: 2. Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: You-Ming
authors.initials: YM
authors.lastname: Li
authors.affiliation: 2. Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Qun-Yan
authors.initials: QY
authors.lastname: Wang
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003731:Dental Caries / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000453:epidemiology* / Q000382:microbiology; D010510:Periodontal Diseases / Q000453:epidemiology / Q000382:microbiology; D012307:Risk Factors; D012463:Saliva / Q000382:microbiology*; D013276:Stomach Ulcer / Q000382:microbiology; D013280:Stomatitis / Q000453:epidemiology / Q000382:microbiology
keywords: Helicobacter pylori; caries; periodontal diseases; recurrent aphthous stomatitis; saliva H.pylori antigen test