title: Real-time monitoring of rolling circle amplification using aggregation-induced emission: applications in biological detection.
abstract: We report that QATPE, an aggregation-induced emission-active tetraphenylethene dye, can be used as a non-sequence-specific ssDNA probe for real-time monitoring of all rolling circle amplification (RCA) reactions, thus making RCA more suitable for biosensing applications.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, People's Republic of China. kongdem@nankai.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300071, People's Republic of China.
authors.forename: Hong-Xin
authors.initials: HX
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, People's Republic of China. kongdem@nankai.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300071, People's Republic of China.
authors.forename: Meng-Yao
authors.initials: MY
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, People's Republic of China. kongdem@nankai.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300071, People's Republic of China.
authors.forename: Chen-Di
authors.initials: CD
authors.lastname: Niu
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, People's Republic of China. kongdem@nankai.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300071, People's Republic of China.
authors.forename: De-Ming
authors.initials: DM
authors.lastname: Kong
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D021141:Nucleic Acid Amplification Techniques
chemical_list: D004277:DNA, Single-Stranded