title: Proteomic approaches to identify circulating biomarkers in patients with abdominal aortic aneurysm.
abstract: Abdominal aortic aneurysm (AAA) is a common condition with high mortality when ruptured. Most clinicians agree that small AAAs are best managed by ultrasonographic surveillance. However, it has been stated in recent reviews that a serum/plasma biomarker that predicts AAA rupture risk would be a powerful tool in stratifying patients with small AAAs. Identification of such circulating biomarkers with traditional hypothesis driven studies has been unsuccessful. In this review we summarize six studies using different proteomic approaches to find new, potential plasma AAA biomarker candidates. In conclusion, by using proteomic approaches novel potential plasma biomarkers for AAA have been identified.
authors.affiliation: Department of Natural Sciences, Mid Sweden University Sundsvall, Sweden.
authors.forename: Dan
authors.initials: D
authors.lastname: Bylund
authors.affiliation: Department of Natural Sciences, Mid Sweden University Sundsvall, Sweden ; Department of Laboratory Medicine, Sundsvall County Hospital Sweden.
authors.forename: Anders E
authors.initials: AE
authors.lastname: Henriksson
keywords: Aortic aneurysm; biomarker; proteomics