title: Hyperchloremic metabolic acidosis following plasma exchange during myasthenia gravis crisis.
abstract: BACKGROUND
  Therapeutic plasma exchanges are increasingly used, notably during myasthenia gravis crisis. Repeated exchanges may induce severe adverse events.
  
  
  METHODS
  We reported a case of symptomatic hyperchloremic metabolic acidosis following a therapeutic plasma exchange. Analysis of 4% albumin substitution solution revealed a chloride concentration of 145 mmol/L, which could explain this acidosis.
  
  
  CONCLUSIONS
  Infusion of high volume of 4% albumin during plasma exchanges may produce hyerchloremic metabolic acidosis.
  
  
  CONCLUSIONS
  Special attention should be paid when repeated plasma exchanges are performed. J. Clin. Apheresis 31:479-480, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Service De Réanimation Neurologique, Hospices Civils De Lyon, Lyon, France. thomas.ritzenthaler@chu-lyon.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ritzenthaler
authors.affiliation: Service De Réanimation Neurologique, Hospices Civils De Lyon, Lyon, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Grousson
authors.affiliation: Service De Réanimation Neurologique, Hospices Civils De Lyon, Lyon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dailler
mesh_terms: D000138:Acidosis / Q000209:etiology*; D000328:Adult; D002712:Chlorides / Q000032:analysis*; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications / Q000628:therapy*; D010951:Plasma Exchange / Q000009:adverse effects*; D012709:Serum Albumin; D012996:Solutions / Q000737:chemistry
chemical_list: D002712:Chlorides; D012709:Serum Albumin; D012996:Solutions
keywords: acid-base disorders; hyperchloremic metabolic acidosis; myasthenia gravis; plasma exchange