title: Oral glucose tolerance test significantly impacts the prevalence of abnormal glucose tolerance among Indian women with polycystic ovary syndrome: lessons from a large database of two tertiary care centers on the Indian subcontinent.
abstract: OBJECTIVE
  To estimate the prevalence of abnormal glucose tolerance (AGT) among Indian women with polycystic ovary syndrome (PCOS) and analyze the role of oral glucose tolerance (OGTT) test on its estimation.
  
  
  METHODS
  Cross-sectional clinical study.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  A total of 2,014 women with PCOS diagnosed on the basis of the Rotterdam 2003 criteria were enrolled, and the data of 1,746 subjects were analyzed.
  
  
  METHODS
  In addition to recording clinical, biochemical, and hormone parameters, a 75 g OGTT was administered.
  
  
  METHODS
  Prevalence of AGT and impact of age, body mass index (BMI), family history, and OGTT on its prevalence.
  
  
  RESULTS
  The mean age of subjects was 23.8 ± 5.3 years, with a mean BMI of 24.9 ± 4.4 kg/m(2). The overall prevalence of AGT was 36.3% (6.3% diabetes and 30% impaired fasting plasma glucose/impaired glucose tolerance) using American Diabetes Association criteria. The glucose intolerance showed a rising trend with advancing age (30.3%, 35.4%, 51%, and 58.8% in the second, third, fourth, and fifth decades, respectively) and increasing BMI. Family history of diabetes mellitus was present in 54.6% (953/1,746) subjects, and it did not correlate with any of the studied parameters except waist circumference and BMI. Sensitivity was better with 2-hour post-OGTT glucose values as compared with fasting plasma glucose, since using fasting plasma glucose alone would have missed the diagnosis in 107 (6.1%) subjects.
  
  
  CONCLUSIONS
  We conclude that AGT is high among young Indian women with PCOS and that it is not predicted by family history of type 2 DM. OGTT significantly improves the detection rate of AGT among Indian women with PCOS.
authors.affiliation: Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India. Electronic address: ashraf.endo@gmail.com.
authors.forename: Mohd Ashraf
authors.initials: MA
authors.lastname: Ganie
authors.affiliation: Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Dhingra
authors.affiliation: Department of Geriatric Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sobia
authors.initials: S
authors.lastname: Nisar
authors.affiliation: Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Vishnubhatla
authors.initials: V
authors.lastname: Sreenivas
authors.affiliation: Department of Immunology and Molecular Medicine, Sheri-Kashmir Institute of Medical Sciences, Kashmir, India.
authors.forename: Zaffar Amin
authors.initials: ZA
authors.lastname: Shah
authors.affiliation: Department of Endocrinology, Sheri-Kashmir Institute of Medical Sciences, Kashmir, India.
authors.forename: Aafia
authors.initials: A
authors.lastname: Rashid
authors.affiliation: Department of Endocrinology, Sheri-Kashmir Institute of Medical Sciences, Kashmir, India.
authors.forename: Shariq
authors.initials: S
authors.lastname: Masoodi
authors.affiliation: Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Nandita
authors.initials: N
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D005951:Glucose Tolerance Test; D006801:Humans; D007194:India / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D011237:Predictive Value of Tests; D015995:Prevalence; D015203:Reproducibility of Results; D062606:Tertiary Care Centers; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: IR; OGTT; PCOS; abnormal glucose tolerance; diabetes mellitus; family history; hyperandrogenism