title: [Potential-dependent Cation Selective Ion Channels Formed by Peroxiredoxin 6 in the Lipid Bilayer].
abstract: The antioxidant enzyme peroxiredoxin 6 forms cation selective ion cluster-type channels in the lipid bilayer. Channel clustering as oligomeric structure consists of three or more subunits--channels with conductance of about 350 pS in the 200 mM KCl. Mean dwell time of the channel's open states decreases with increasing membrane voltage. A possible molecular mechanism of the observed potential-dependent inactivation of the channel cluster is discussed.
authors.forename: P A
authors.initials: PA
authors.lastname: Grigoriev
authors.forename: M G
authors.initials: MG
authors.lastname: Sharapov
authors.forename: V I
authors.initials: VI
authors.lastname: Novoselov
mesh_terms: D002414:Cations, Monovalent; D002712:Chlorides / Q000737:chemistry; D004553:Electric Conductivity; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000737:chemistry*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D008564:Membrane Potentials; D054465:Peroxiredoxin VI / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D011188:Potassium / Q000737:chemistry; D021122:Protein Subunits / Q000737:chemistry*; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D002414:Cations, Monovalent; D002712:Chlorides; D007473:Ion Channels; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D021122:Protein Subunits; D011994:Recombinant Proteins; D054465:Peroxiredoxin VI; D011188:Potassium