title: Autocrine signaling of type 1 interferons in successful anticancer chemotherapy.
abstract: Anthracycline-based chemotherapies are particularly effective if they succeed in reinstating immunosurveillance by the induction of immunogenic cell death (ICD) in the tumor. Recently, we discovered that ICD is coupled to the induction of type 1 interferons (IFNs-I) that act in an autocrine fashion on cancer cells, thereby increasing their immunogenic potential.
authors.affiliation: Gustave Roussy Cancer Campus ; Villejuif, France ; Université Paris XI, Faculté de Médecine; Le Kremlin Bicêtre , France ; INSERM; U1138 ; Paris, France.
authors.forename: Erika
authors.initials: E
authors.lastname: Vacchelli
authors.affiliation: Gustave Roussy Cancer Campus ; Villejuif, France ; Université Paris XI, Faculté de Médecine; Le Kremlin Bicêtre , France ; INSERM, U1015 ; Villejuif, France ; Regina Elena National Cancer Institute ; Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Sistigu
authors.affiliation: Gustave Roussy Cancer Campus ; Villejuif, France ; Université Paris XI, Faculté de Médecine; Le Kremlin Bicêtre , France ; INSERM, U1015 ; Villejuif, France.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamazaki
authors.affiliation: Regina Elena National Cancer Institute ; Rome, Italy ; University of Rome "Tor Vergata", Department of Biology ; Rome, Italy.
authors.forename: Ilio
authors.initials: I
authors.lastname: Vitale
authors.affiliation: Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM; U1138 ; Paris, France ; INSERM, U1015 ; Villejuif, France ; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507 ; Villejuif, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
authors.affiliation: Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM; U1138 ; Paris, France ; Metabolomics Platform, Gustave Roussy Cancer Campus; Villejuif , France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers ; Paris, France ; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP ; Paris, France ; Université Paris Descartes, Sorbonne Paris Cité ; Paris, France ; Department of Biology and Pathology, Gustave Roussy Cancer Campus ; Villejuif, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
keywords: IFN; TLR3; cancer; immunogenic chemotherapy; tumor immunity