title: Evaluation of two blood microsampling approaches for drug discovery PK studies in rats.
abstract: BACKGROUND
  Serial sampling in discovery rat PK studies could be performed via capillary microsampling (CMS) of blood or by using the Mitra™ device to collect dried blood samples.
  
  
  RESULTS
  Blood CMS results were compared with Mitra sampling results for four test compounds dosed in rat PK studies. The PK profiles obtained from CMS sampling were found to be very similar to those obtained from the Mitra sampling. For 15-µl blood CMS samples, freezing before the dilution step was found to be acceptable.
  
  
  CONCLUSIONS
  Blood CMS using 15-µl glass capillary microsamples works well for serial blood sampling in rat PK studies. The Mitra microsampling device provides an alternative method for collecting 10 µl of blood as a dried blood sample.
authors.affiliation: Drug Metabolism & Pharmacokinetics, Sanofi, Second Avenue, Waltham, MA 02451, USA.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Drug Metabolism & Pharmacokinetics, Sanofi, Second Avenue, Waltham, MA 02451, USA.
authors.forename: Walter
authors.initials: W
authors.lastname: Korfmacher
authors.affiliation: Drug Metabolism & Pharmacokinetics, Sanofi, Second Avenue, Waltham, MA 02451, USA.
authors.forename: Stacy
authors.initials: S
authors.lastname: Ho
authors.affiliation: Drug Metabolism & Pharmacokinetics, Sanofi, Second Avenue, Waltham, MA 02451, USA.
authors.forename: Liduo
authors.initials: L
authors.lastname: Shen
authors.affiliation: Drug Metabolism & Pharmacokinetics, Sanofi, Second Avenue, Waltham, MA 02451, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Drug Metabolism & Pharmacokinetics, Sanofi, Second Avenue, Waltham, MA 02451, USA.
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Drug Metabolism & Pharmacokinetics, Sanofi, Second Avenue, Waltham, MA 02451, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Agilux, 1 Innovation Drive, Worcester, MA 01605, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Snow
authors.affiliation: Drug Metabolism & Pharmacokinetics, Sanofi, Second Avenue, Waltham, MA 02451, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: O'Shea