title: Gray matter volume alterations in first-episode drug-naïve patients with deficit and nondeficit schizophrenia.
abstract: Different patterns of gray matter volume (GMV) abnormalities have been reported between chronic patients with deficit schizophrenia (DS), relative to nondeficit schizophrenia (NDS) patients. However, it is not clear whether these differences are characteristic to the pathophysiology of DS or due to the effects of medications or illness durations. To address this issue, GMV in 88 first-episode, drug-naive patients with schizophrenia (44 DS and 44 NDS), 67 of their first-degree relatives and 84 healthy controls were assessed using voxel- based morphometry (VBM) and compared between groups. Correlations between GMV and clinical symptoms in patients were also assessed. Compared to controls, DS patients displayed more severe GMV reduction in the cerebellar culmen than NDS patients. GMV reduction in culmen was also observed in the first-degree relatives of DS (but not NDS) patients, suggesting possible different genetic risk in DS and NDS. The left insula was significantly smaller in DS patients than both NDS patients and controls, and smaller GMV of this region was associated with more severe negative symptoms in patients. Our results collectively indicate that DS might represent a distinct subtype of schizophrenia from NDS and the GMV change in left insula may be a morphological signature of DS.
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lei
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Mingli
authors.initials: M
authors.lastname: Li
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Zongling
authors.initials: Z
authors.lastname: He
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Han
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Chaohua
authors.initials: C
authors.lastname: Huang
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Wanjun
authors.initials: W
authors.lastname: Guo
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Yinfei
authors.initials: Y
authors.lastname: Li
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Huaxi MRI center, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Clinical Neuroscience, King's College London, Medical Research Council (MRC) Centre for Neurodegeneration Research, Institute of Psychiatry, London, UK.
authors.forename: Xun
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Biomedical Engineering, The Huck Institutes of the Life Sciences,The Pennsylvania State University, W-341 Millennium Science Complex, University Park, PA 16802, USA.
authors.forename: Nanyin
authors.initials: N
authors.lastname: Zhang
authors.affiliation: The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D054022:Cerebrum / Q000378:metabolism / Q000473:pathology; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D012559:Schizophrenia / Q000145:classification* / Q000175:diagnosis* / Q000378:metabolism; D055815:Young Adult
keywords: Deficit Schizophrenia; Gray matter volume; Voxel-based morphometry