title: Genetically engineered mouse models for studying inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that is mediated by very complex mechanisms controlled by genetic, immune, and environmental factors. More than 74 kinds of genetically engineered mouse strains have been established since 1993 for studying IBD. Although mouse models cannot fully reflect human IBD, they have provided significant contributions for not only understanding the mechanism, but also developing new therapeutic means for IBD. Indeed, 20 kinds of genetically engineered mouse models carry the susceptibility genes identified in human IBD, and the functions of some other IBD susceptibility genes have also been dissected out using mouse models. Cutting-edge technologies such as cell-specific and inducible knockout systems, which were recently employed to mouse IBD models, have further enhanced the ability of investigators to provide important and unexpected rationales for developing new therapeutic strategies for IBD. In this review article, we briefly introduce 74 kinds of genetically engineered mouse models that spontaneously develop intestinal inflammation.
authors.affiliation: Department of Immunology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizoguchi
authors.affiliation: Department of Immunology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Takeuchi
authors.affiliation: Department of Immunology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Himuro
authors.affiliation: Department of Immunology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Okada
authors.affiliation: Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Fruit Street, Boston, MA, 02114, USA.
authors.forename: Emiko
authors.initials: E
authors.lastname: Mizoguchi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics; D004195:Disease Models, Animal; D018390:Gene Targeting; D052138:Genes, Neoplasm / Q000235:genetics; D005818:Genetic Engineering; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D009363:Neoplasm Proteins / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
chemical_list: D016207:Cytokines; D009363:Neoplasm Proteins
keywords: ER stress; IBD susceptibility gene; epithelial barrier; immunoregulation; knockout mice; mouse models