title: Evaluation of Estrogen, Progesterone, and GCDFP-15 Expression in Uterine Leiomyomas.
abstract: Approximately, one fourth of women have leiomyomas. Leiomyomas are benign tumors that originated from smooth muscle cells. Estrogen is claimed to relate as a cause but exact mechanism has not fully understood. In this study, 95 leiomyoma cases that have been diagnosed by our department in years between 2010 and 2012 were examined. Age ranges of patients, sizes, locations, and numbers of leiomyomas were identified. Immunohistochemically ER (estrogen), PR (progesterone), and Gross cystic disease fluid protein-15 stains were performed to the paraffin blocks and their percentages of staining were noted. Statistically, submucosal and intramural locations were significantly related to ER and PR (p < 0,001). There were significant relationship between ER and PR in 30-50 years age group (p < 0,001). There were significant relationship between ER, PR and locations (p < 0,001), numbers (p < 0,001), sizes of leiomyomas (below 5 cm; p < 0,001), (between 5 and 10 cm; p = 0,037), larger than 10 cm; p = 0,002). Consequently, relationship between leiomyoma and ER, PR were revealed in this study. Also, relationship between leiomyoma locations and patient ages were identified statistically. There was no immunoreactivity with GCDFP-15 in leiomyomas.
authors.affiliation: Department of Pathology, Duzce University of Medical Faculty, Duzce, Turkey.
authors.forename: Havva
authors.initials: H
authors.lastname: Erdem
authors.affiliation: Department of Pathology, Duzce University of Medical Faculty, Duzce, Turkey.
authors.forename: Feyza
authors.initials: F
authors.lastname: Başar
authors.affiliation: Department of Pathology, Duzce University of Medical Faculty, Duzce, Turkey.
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Kadıoğlu
authors.affiliation: Department of Pathology, Duzce University of Medical Faculty, Duzce, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Oktay
authors.affiliation: Department of Biostatistic, Duzce University of Medical Faculty, Duzce, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Ankaralı
authors.affiliation: Department of Obstetrics and Gynecology, Düzce University of Medical Faculty, Duzce, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yavuzcan
authors.affiliation: Department of Biophysics, Duzce University of Medical Faculty, Duzce, Turkey.
authors.forename: Anzel
authors.initials: A
authors.lastname: Bahadır
authors.affiliation: Department of Obstetrics and Gynecology, Düzce University of Medical Faculty, Duzce, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Dilbaz
keywords: ER; GCDFP-15; PR; Uterine leiomyoma