title: Enlargement of choroid plexus in complex regional pain syndrome.
abstract: The choroid plexus, located in brain ventricles, has received surprisingly little attention in clinical neuroscience. In morphometric brain analysis, we serendipitously found a 21% increase in choroid plexus volume in 12 patients suffering from complex regional pain syndrome (CRPS) compared with age- and gender-matched healthy subjects. No enlargement was observed in a group of 8 patients suffering from chronic pain of other etiologies. Our findings suggest involvement of the choroid plexus in the pathogenesis of CRPS. Since the choroid plexus can mediate interaction between peripheral and brain inflammation, our findings pinpoint the choroid plexus as an important target for future research of central pain mechanisms.
authors.affiliation: Department of Neuroscience and Biomedical Engineering, Aalto University, FI-00076 AALTO, Espoo 02150, Finland.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Neuroscience and Biomedical Engineering, Aalto University, FI-00076 AALTO, Espoo 02150, Finland.|Aalto NeuroImaging, Aalto University, Espoo 02150, Finland.|Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Hotta
authors.affiliation: Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Maria K
authors.initials: MK
authors.lastname: Lehtinen
authors.affiliation: Department of Neuroscience and Biomedical Engineering, Aalto University, FI-00076 AALTO, Espoo 02150, Finland.|Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland.
authors.forename: Nina
authors.initials: N
authors.lastname: Forss
authors.affiliation: Department of Neuroscience and Biomedical Engineering, Aalto University, FI-00076 AALTO, Espoo 02150, Finland.
authors.forename: Riitta
authors.initials: R
authors.lastname: Hari
mesh_terms: D000328:Adult; D000368:Aged; D002831:Choroid Plexus / Q000473:pathology*; D020918:Complex Regional Pain Syndromes / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008875:Middle Aged