title: Peripheral eosinophilia - is it a predictable factor associated with eosinophilic cholecystitis?
abstract: OBJECTIVE
  The purpose of this study was to evaluate the role of peripheral eosinophilia as a predictable factor associated with Eosinophilic cholecystitis (EC) compared with other forms of cholecystitis in patients who underwent a cholecystectomy.
  
  
  METHODS
  Between January 2001 and May 2011, the histopathologic features of 3,539 cholecystectomy specimens were reviewed retrospectively. EC was diagnosed in 30 specimens (0.84%). Data from 30 consecutive patients with EC (eosinophilic cholecystitis group [E-group]) were compared with a retrospective control group of 60 patients (other cholecystitis group [O-group]) during the same period. The two groups were matched for age, gender, and the presence of cholelithiasis.
  
  
  RESULTS
  The median absolute eosinophil count 1 day post-operatively was 144 cells/mm(3) (range: 9-801 cells/mm(3)) in the E-group and 93 cells/mm(3) (range: 0-490 cells/mm(3)) in the O-group (p=0.036). Pre-operative peripheral eosinophilia was more common in the E-group than the O-group (20% vs. 3.3%, p=0.015). Multivariate analysis revealed that pre-operative peripheral eosinophilia was an independent significant predictable factor associated with EC (odds ratio=7.250, 1.365 <95% confidence interval<38.494, p=0.020).
  
  
  CONCLUSIONS
  In the present study, pre-operative peripheral eosinophilia was shown to be an independent predictable factor associated with EC. Further researches seem to be necessary to confirm this finding.
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Seung-Seop
authors.initials: SS
authors.lastname: Yeom
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Ho-Hyun
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Jung-Chul
authors.initials: JC
authors.lastname: Kim
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Young-Hoe
authors.initials: YH
authors.lastname: Hur
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Koh
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Chol-Kyoon
authors.initials: CK
authors.lastname: Cho
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Hyun-Jong
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Radiology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Shin
authors.affiliation: Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Hyung-Seok
authors.initials: HS
authors.lastname: Kim
keywords: Cholecystectomy; Eosinophilia; Eosinophilic cholecystitis; Predictable factor