title: A comparative study of red and blue light-emitting diodes and low-level laser in regeneration of the transected sciatic nerve after an end to end neurorrhaphy in rabbits.
abstract: This study aimed at evaluating the effects of red and blue light-emitting diodes (LED) and low-level laser (LLL) on the regeneration of the transected sciatic nerve after an end-to-end neurorrhaphy in rabbits. Forty healthy mature male New Zealand rabbits were randomly assigned into four experimental groups: control, LLL (680 nm), red LED (650 nm), and blue LED (450 nm). All animals underwent the right sciatic nerve neurotmesis injury under general anesthesia and end-to-end anastomosis. The phototherapy was initiated on the first postoperative day and lasted for 14 consecutive days at the same time of the day. On the 30th day post-surgery, the animals whose sciatic nerves were harvested for histopathological analysis were euthanized. The nerves were analyzed and quantified the following findings: Schwann cells, large myelinic axons, and neurons. In the LLL group, as compared to other groups, an increase in the number of all analyzed aspects was observed with significance level (P < 0.05). This finding suggests that postoperative LLL irradiation was able to accelerate and potentialize the peripheral nerve regeneration process in rabbits within 14 days of irradiation.
authors.affiliation: Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran. dr_ashrafzadeh@yahoo.com.
authors.forename: Mohammad Ashrafzadeh
authors.initials: MA
authors.lastname: Takhtfooladi
authors.affiliation: Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
authors.forename: Davood
authors.initials: D
authors.lastname: Sharifi
mesh_terms: D000818:Animals; D003116:Color; D008027:Light; D028022:Low-Level Light Therapy; D008297:Male; D009416:Nerve Regeneration / Q000528:radiation effects*; D019635:Neurosurgical Procedures; D011184:Postoperative Period; D011817:Rabbits; D012584:Sciatic Nerve / Q000166:cytology / Q000502:physiology* / Q000528:radiation effects / Q000601:surgery*; D012666:Semiconductors
keywords: Blue LED; Low-level laser; Nerve regeneration; Photobiomodulation; Red LED; Sciatic