title: Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study.
abstract: This study examined changes in prefrontal oxy-Hb levels measured by NIRS (Near-Infrared Spectroscopy) during a facial-emotion recognition task in healthy adults, testing a mediational/moderational model of these variables. Fifty-three healthy adults (male = 35, female = 18) aged between 22 to 37 years old (mean age = 24.05 years old) provided saliva samples, completed a EMBU questionnaire (Swedish acronym for Egna Minnen Beträffande Uppfostran [My memories of upbringing]), and participated in a facial-emotion recognition task during NIRS recording. There was a main effect of maternal rejection on RoxH (right frontal activation during an ambiguous task), and a gene × environment (G × E) interaction on RoxH, suggesting that individuals who carry the SL or LL genotype and who endorse greater perceived maternal rejection show less right frontal activation than SL/LL carriers with lower perceived maternal rejection. Finally, perceived parenting style played a mediating role in right frontal activation via the 5-HTTLPR genotype. Early-perceived parenting might influence neural activity in an uncertain situation i.e. rating ambiguous faces among individuals with certain genotypes. This preliminary study makes a small contribution to the mapping of an influence of gene and behaviour on the neural system. More such attempts should be made in order to clarify the links.
authors.affiliation: Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, Hiroshima, Japan; Phoenix Leader Education Program, Hiroshima University, Hiroshima City, Hiroshima, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Nishikawa
authors.affiliation: Department of Psychology, Graduate School of Education, Hiroshima University, Higashi Hiroshima City, Hiroshima, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Toshima
authors.affiliation: Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, Hiroshima, Japan; Phoenix Leader Education Program, Hiroshima University, Hiroshima City, Hiroshima, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D000483:Alleles; D004644:Emotions; D005149:Facial Expression; D000066499:Facial Recognition; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D005838:Genotype; D006801:Humans; D008297:Male; D009424:Nervous System Physiological Phenomena; D016487:Parenting; D010465:Perception; D010865:Pilot Projects; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins