title: Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions.
abstract: Non-Hodgkin's lymphomas (NHLs) are malignant neoplasms which are clinically and biologically diverse. Their incidence is constantly increasing and despite treatment advances, there is a need for novel targeted therapies. Here, we identified Lectin-like transcript 1 (LLT1) as a biomarker of germinal center (GC)-derived B-cell NHLs. LLT1 identifies GC B cells in reactive tonsils and lymph nodes and its expression is maintained in B-cell NHLs which derive from GC, including Burkitt lymphoma (BL), follicular lymphoma (FL), and GC-derived diffuse large B-cell lymphoma (DLBCL). We further show that LLT1 expression by tumors dampens natural killer (NK) cell functions following interaction with its receptor CD161, uncovering a potential immune escape mechanism. Our results pinpoint LLT1 as a novel biomarker of GC-derived B-cell NHLs and as a candidate target for innovative immunotherapies.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275 ; Valbonne, France ; Université de Nice-Sophia Antipolis ; Valbonne, France ; Laboratory "Cancer, Immune control and Escape,", Cordeliers Research Center; UMRS1138 ; Paris, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Germain
authors.affiliation: Université de Rennes 1; INSERM, Unité 917; EFS Bretagne; UMS 3480CNRS 018INSERM Biosit ; Rennes, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Guillaudeux
authors.affiliation: Biopharmaceutical Research Unit, Novo Nordisk A/S , DK-2760; Måløv, Denmark.
authors.forename: Elisabeth D
authors.initials: ED
authors.lastname: Galsgaard
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275 ; Valbonne, France ; Université de Nice-Sophia Antipolis ; Valbonne, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Hervouet
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275 ; Valbonne, France ; Université de Nice-Sophia Antipolis ; Valbonne, France.
authors.forename: Nedra
authors.initials: N
authors.lastname: Tekaya
authors.affiliation: Université de Rennes 1; INSERM, Unité 917; EFS Bretagne; UMS 3480CNRS 018INSERM Biosit ; Rennes, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Gallouet
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275 ; Valbonne, France ; Université de Nice-Sophia Antipolis ; Valbonne, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Fassy
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275 ; Valbonne, France ; Université de Nice-Sophia Antipolis ; Valbonne, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Bihl
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275 ; Valbonne, France ; Université de Nice-Sophia Antipolis ; Valbonne, France.
authors.forename: Gwenola
authors.initials: G
authors.lastname: Poupon
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275 ; Valbonne, France ; Université de Nice-Sophia Antipolis ; Valbonne, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Lazzari
authors.affiliation: Biopharmaceutical Research Unit, Novo Nordisk A/S , DK-2760; Måløv, Denmark.
authors.forename: Pieter
authors.initials: P
authors.lastname: Spee
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275 ; Valbonne, France ; Université de Nice-Sophia Antipolis ; Valbonne, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Anjuère
authors.affiliation: Université de Rennes 1; INSERM, Unité 917, EFS Bretagne; CHU de Rennes, Service d'Hématologie, UMS 3480CNRS 018INSERM Biosit ; Rennes, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Pangault
authors.affiliation: Université de Rennes 1; INSERM, Unité 917, EFS Bretagne; CHU de Rennes, Service d'Hématologie, UMS 3480CNRS 018INSERM Biosit ; Rennes, France.
authors.forename: Karin
authors.initials: K
authors.lastname: Tarte
authors.affiliation: Université de Rennes 1; INSERM, Unité 917, EFS Bretagne; CHU de Rennes, Service d'Hématologie, UMS 3480CNRS 018INSERM Biosit ; Rennes, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Tas
authors.affiliation: Département d'Oncologie Moléculaire; Centre de Recherche en Cancérologie de Marseille; INSERM UMR89 , IFR137; Marseille, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Xerri
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275 ; Valbonne, France ; Université de Nice-Sophia Antipolis ; Valbonne, France.
authors.forename: Veronique M
authors.initials: VM
authors.lastname: Braud
keywords: CD161; LLT1; germinal center; natural killer cells; non-Hodgkin's B-cell lymphoma