title: Research on the Pathological Mechanism and Drug Treatment Mechanism of Depression.
abstract: Depression is one of the prevalent and persistent psychiatric illnesses. It brings heavy socioeconomic burden such as healthcare expenditures and even higher suicide rates. Despite many hypotheses about its mechanism have been put forward, so far it is still unclear, not to mention the precise and effective diagnostic or therapeutic methods. In this paper, the current conditions of pathological and pharmacological mechanism of depression were reviewed systematically. Firstly, the most recent hypotheses and metabolomics based research including hereditary, neurotransmitter systems, brain derived neurotrophic factor (BDNF), hyperactivity of the hypothalamic pituitary adrenal (HPA) axis and inflammatory as well as metabolomics were summarized. Secondly, the present situation and development on antidepressant drugs at home and abroad were reviewed. Finally, a conclusion and prospect on the pathological and pharmacological mechanism of depression were provided primarily.
authors.forename: Guo-jiang
authors.initials: GJ
authors.lastname: Peng
authors.forename: Jun-sheng
authors.initials: JS
authors.lastname: Tian
authors.forename: Xiao-xia
authors.initials: XX
authors.lastname: Gao
authors.forename: Yu-zhi
authors.initials: YZ
authors.lastname: Zhou
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, PR China.
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Qin
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000473:pathology; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D012106:Research / Q000639:trends
chemical_list: D000928:Antidepressive Agents