title: Introduction to special issue on biomarker-based clinical trial designs in oncology.
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Sargent.Daniel@mayo.edu.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sargent
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Mandrekar.Sumithra@mayo.edu.
authors.forename: Sumithra
authors.initials: S
authors.lastname: Mandrekar
authors.affiliation: Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA. GROTHEY.AXEL@mayo.edu.
authors.forename: Axel
authors.initials: A
authors.lastname: Grothey
mesh_terms: D014408:Biomarkers, Tumor / Q000502:physiology*; D002986:Clinical Trials as Topic / Q000379:methods*; D055808:Drug Discovery / Q000379:methods; D016903:Drug Monitoring / Q000379:methods / Q000639:trends; D006801:Humans; D008495:Medical Oncology / Q000379:methods*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D012107:Research Design
chemical_list: D014408:Biomarkers, Tumor