title: Changes in the Morphological and Immunological Characteristics of Mel Ibr Melanoma Cells in Response to Chicken Embryo Extract.
abstract: Exposure of Mel Ibr human melanoma cells to chicken embryo extract resulted in the appearance of a subclone with morphological and growth characteristics similar to those of embryonic stem cells. The subclone differed from the parental line cells by a sharply reduced percentage of HLA-DR(+) and CD54(+) cells, a significantly elevated percentage of CD63(+) cells, and appearance of CD133(+) and Oct-4A(+) cells. Hence, the subclone cells were characterized by the same features as stem tumor cells and could be responsible for further progress of tumor growth.
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. nsuraeva@yandex.ru.
authors.forename: N M
authors.initials: NM
authors.lastname: Suraeva
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: L F
authors.initials: LF
authors.lastname: Morozova
authors.affiliation: All-Russian Research Institute of Preservation Technology, Moscow Region, Vidnoe, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Samoilov
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Burova
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Golubeva
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Baryshnikova
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Baryshnikov
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D048430:Cell Shape / Q000187:drug effects; D002642:Chick Embryo; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008545:Melanoma / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy; D014020:Tissue Extracts / Q000494:pharmacology
chemical_list: D015703:Antigens, CD; D000970:Antineoplastic Agents; D014020:Tissue Extracts
keywords: chicken embryo extract; dedifferentiation; melanoma cell line; subclone