title: Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women.
abstract: A unique renal neoplasm characterized by eosinophilic cytoplasm and solid and cystic growth was recently reported in patients with tuberous sclerosis complex (TSC). We searched multiple institutional archives and consult files in an attempt to identify a sporadic counterpart. We identified 16 morphologically identical cases, all in women, without clinical features of TSC. The median age was 57 years (range, 31 to 75 y). Macroscopically, tumors were tan and had a solid and macrocystic (12) or only solid appearance (4). Average tumor size was 50 mm (median, 38.5 mm; range, 15 to 135 mm). Microscopically, the tumors showed solid areas admixed with variably sized macrocysts and microcysts that were lined by cells with a pronounced hobnail arrangement. The cells had voluminous eosinophilic cytoplasm with prominent granular cytoplasmic stippling and round to oval nuclei with prominent nucleoli. Scattered histiocytes and lymphocytes were invariably present. Thirteen of 16 patients were stage pT1; 2 were pT2, and 1 was pT3a. The cells demonstrated a distinct immunoprofile: nuclear PAX8 expression, predominant CK20-positive/CK7-negative phenotype, patchy AMACR staining, but no CD117 reactivity. Thirteen of 14 patients with follow-up were alive and without disease progression after 2 to 138 months (mean: 53 mo; median: 37.5 mo); 1 patient died of other causes. Although similar to a subset of renal cell carcinomas (RCCs) seen in TSC, we propose that sporadic "eosinophilic, solid, and cystic RCC," which occurs predominantly in female individuals and is characterized by distinct morphologic features, predominant CK20-positive/CK7-negative immunophenotype, and indolent behavior, represents a novel subtype of RCC.
authors.affiliation: *Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada †Department of Pathology, Charles University, Pilsen, Czech Republic ‡Cruces University Hospital, BioCruces Institute, University of the Basque Country (UPV/EHU), Barakaldo, Bizkaia, Spain §Nephropath, Little Rock, AR ‡‡Medical College Wisconsin, Milwaukee, WI §§El Camino Hospital, Mountain View ∥∥Stanford University Hospital, Stanford, CA ¶¶New York University Medical Center, New York, NY ***Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH ∥Carregi Hospital, Florence, Italy ¶Pitié-Salpêtrière Hospital #Hopital Cochin, Paris, France **Barts Cancer Institute, Queen Mary University of London, London, United Kingdom ††University Hospital Dubrava, Zagreb, Croatia ##Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.
authors.forename: Kiril
authors.initials: K
authors.lastname: Trpkov
authors.forename: Ondrej
authors.initials: O
authors.lastname: Hes
authors.forename: Michael
authors.initials: M
authors.lastname: Bonert
authors.forename: Jose I
authors.initials: JI
authors.lastname: Lopez
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Bonsib
authors.forename: Gabriella
authors.initials: G
authors.lastname: Nesi
authors.forename: Eva
authors.initials: E
authors.lastname: Comperat
authors.forename: Mathilde
authors.initials: M
authors.lastname: Sibony
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Berney
authors.forename: Petr
authors.initials: P
authors.lastname: Martinek
authors.forename: Stela
authors.initials: S
authors.lastname: Bulimbasic
authors.forename: Saul
authors.initials: S
authors.lastname: Suster
authors.forename: Ankur
authors.initials: A
authors.lastname: Sangoi
authors.forename: Asli
authors.initials: A
authors.lastname: Yilmaz
authors.forename: John P
authors.initials: JP
authors.lastname: Higgins
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Gill
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Przybycin
authors.forename: Cristina
authors.initials: C
authors.lastname: Magi-Galluzzi
authors.forename: Jesse K
authors.initials: JK
authors.lastname: McKenney
mesh_terms: D000328:Adult; D000368:Aged; D001315:Australia; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D055028:Comparative Genomic Hybridization; D018450:Disease Progression; D018572:Disease-Free Survival; D004804:Eosinophils / Q000737:chemistry / Q000473:pathology*; D005060:Europe; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009367:Neoplasm Staging; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D009656:North America; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor