title: LEARNING NONRIGID DEFORMATIONS FOR CONSTRAINED POINT-BASED REGISTRATION FOR IMAGE-GUIDED MR-TRUS PROSTATE INTERVENTION.
abstract: This paper presents and validates a low-dimensional nonrigid registration method for fusing magnetic resonance imaging (MRI) and trans-rectal ultrasound (TRUS) in image-guided prostate biopsy. Prostate cancer is one of the most prevalent forms of cancer and the second leading cause of cancer-related death in men in the United States. Conventional clinical practice uses TRUS to guide prostate biopsies when there is a suspicion of cancer. Pre-procedural MRI information can reveal lesions and may be fused with intra-procedure TRUS imaging to provide patient-specific, localization of lesions for targeting. The state-of-the-art MRI-TRUS nonrigid image fusion process relies upon semi-automated segmentation of the prostate in both the MRI and TRUS images. In this paper, we develop a fast, automated nonrigid registration approach to MRI-TRUS fusion based on a statistical deformation model of intra-procedural deformations derived from a clinical sample.
authors.affiliation: Department of Diagnostic Radiology, Yale University, New Haven, CT, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Onofrey
authors.affiliation: Department of Diagnostic Radiology, Yale University, New Haven, CT, USA ; Department of Biomedical Engineering, Yale University, New Haven, CT, USA ; Department of Electrical Engineering, Yale University, New Haven, CT, USA.
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Staib
authors.affiliation: Department of Eigen, Grass Valley, CA, USA.
authors.forename: Saradwata
authors.initials: S
authors.lastname: Sarkar
authors.affiliation: Department of Eigen, Grass Valley, CA, USA.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Venkataraman
authors.affiliation: Department of Diagnostic Radiology, Yale University, New Haven, CT, USA ; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
authors.forename: Xenophon
authors.initials: X
authors.lastname: Papademetris
keywords: image-guided intervention; nonrigid registration; prostate biopsy; robust point matching; statistical deformation model