title: Photopatternable Biodegradable Aliphatic Polyester with Pendent Benzophenone Groups.
abstract: Highly efficient photo-cross-linking reactions enable numerous applications in biomaterials. Here, a photopatternable biodegradable aliphatic polyester with benzophenone pendent groups was synthesized by copper-catalyzed alkyne-azide cycloaddition, affording polyesters that undergo UV-induced cross-linking to yield photopatterned films. Using this material, a self-folding multilayer structure containing polyester/hydrogel bilayer hinges was fabricated. Upon swelling of the hydrogel layer, the construct folds into a triangular tube, which subsequently unfolds due to lipase-catalyzed degradation of the polyester layer. The ability to precisely design such degradation-induced structural changes offers potential for biomaterials and medical applications, such as evolving and responsive 2D and 3D tissue engineering scaffolds.
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts Amherst , 120 Governors Drive, Amherst, Massachusetts 01003, United States.
authors.forename: Dayong
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts Amherst , 120 Governors Drive, Amherst, Massachusetts 01003, United States.
authors.forename: Chia-Chih
authors.initials: CC
authors.lastname: Chang
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts Amherst , 120 Governors Drive, Amherst, Massachusetts 01003, United States.
authors.forename: Beth
authors.initials: B
authors.lastname: Cooper
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts Amherst , 120 Governors Drive, Amherst, Massachusetts 01003, United States.
authors.forename: Angela
authors.initials: A
authors.lastname: Silvers
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts Amherst , 120 Governors Drive, Amherst, Massachusetts 01003, United States.
authors.forename: Todd
authors.initials: T
authors.lastname: Emrick
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts Amherst , 120 Governors Drive, Amherst, Massachusetts 01003, United States.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Hayward
mesh_terms: D001577:Benzophenones / Q000737:chemistry*; D006801:Humans; D011091:Polyesters / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D011091:Polyesters