title: Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia.
abstract: OBJECTIVE
  Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate disease-specific early pregnancy serum cytokine profiles of women subsequently developing gestational hypertension or preeclampsia for new insight into the underlying pathogeneses and differences between the disorders.
  
  
  RESULTS
  The study cohort consisted of 548 pregnant Norwegian women who were either multiparous with previous gestational hypertension or preeclampsia or were nulliparous. Maternal sera at gestational weeks 11(0)-13(6) were assayed for 27 cytokines, C-reactive protein, total cholesterol, high-density lipoprotein, triglyceride, creatinine, calcium, uric acid, and placental growth factor. Compared with normotensive women, women with both hypertensive conditions presented an atherogenic lipid profile at early gestation, but only those later developing gestational hypertension had significantly higher serum levels of interleukin (IL)-5 and IL-12. Comparing the 2 hypertensive pregnancy disorders, women subsequently developing gestational hypertension had higher serum levels of IL-1β, IL-5, IL-7, IL-8, IL-13, basic fibroblast growth factor, and vascular endothelial growth factor than the women subsequently developing preeclampsia.
  
  
  CONCLUSIONS
  This study identifies early pregnancy differences in serum cytokine profiles for gestational hypertension and preeclampsia.
authors.affiliation: From the Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine (L.H.T., R.A., A.-C.I.), Department of Circulation and Medical Imaging (M.A., T.F.B.), and Department of Laboratory Medicine Children's and Women's Health (R.B.S., K.Å.S.), Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (L.H.T., M.A.); and National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (R.B.S., K.Å.S.). line.tangeras@ntnu.no ann-charlotte.iversen@ntnu.no.
authors.forename: Line H
authors.initials: LH
authors.lastname: Tangerås
authors.affiliation: From the Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine (L.H.T., R.A., A.-C.I.), Department of Circulation and Medical Imaging (M.A., T.F.B.), and Department of Laboratory Medicine Children's and Women's Health (R.B.S., K.Å.S.), Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (L.H.T., M.A.); and National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (R.B.S., K.Å.S.).
authors.forename: Marie
authors.initials: M
authors.lastname: Austdal
authors.affiliation: From the Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine (L.H.T., R.A., A.-C.I.), Department of Circulation and Medical Imaging (M.A., T.F.B.), and Department of Laboratory Medicine Children's and Women's Health (R.B.S., K.Å.S.), Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (L.H.T., M.A.); and National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (R.B.S., K.Å.S.).
authors.forename: Ragnhild B
authors.initials: RB
authors.lastname: Skråstad
authors.affiliation: From the Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine (L.H.T., R.A., A.-C.I.), Department of Circulation and Medical Imaging (M.A., T.F.B.), and Department of Laboratory Medicine Children's and Women's Health (R.B.S., K.Å.S.), Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (L.H.T., M.A.); and National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (R.B.S., K.Å.S.).
authors.forename: Kjell Å
authors.initials: KÅ
authors.lastname: Salvesen
authors.affiliation: From the Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine (L.H.T., R.A., A.-C.I.), Department of Circulation and Medical Imaging (M.A., T.F.B.), and Department of Laboratory Medicine Children's and Women's Health (R.B.S., K.Å.S.), Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (L.H.T., M.A.); and National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (R.B.S., K.Å.S.).
authors.forename: Rigmor
authors.initials: R
authors.lastname: Austgulen
authors.affiliation: From the Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine (L.H.T., R.A., A.-C.I.), Department of Circulation and Medical Imaging (M.A., T.F.B.), and Department of Laboratory Medicine Children's and Women's Health (R.B.S., K.Å.S.), Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (L.H.T., M.A.); and National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (R.B.S., K.Å.S.).
authors.forename: Tone F
authors.initials: TF
authors.lastname: Bathen
authors.affiliation: From the Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine (L.H.T., R.A., A.-C.I.), Department of Circulation and Medical Imaging (M.A., T.F.B.), and Department of Laboratory Medicine Children's and Women's Health (R.B.S., K.Å.S.), Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (L.H.T., M.A.); and National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway (R.B.S., K.Å.S.). line.tangeras@ntnu.no ann-charlotte.iversen@ntnu.no.
authors.forename: Ann-Charlotte
authors.initials: AC
authors.lastname: Iversen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood*; D009664:Norway; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators
keywords: cytokines; first trimester; gestational hypertension; inflammation; preeclampsia