title: Impact of lung disease on respiratory impedance in young children with cystic fibrosis.
abstract: This study aimed to evaluate the ability of the forced oscillation technique (FOT) to detect underlying lung disease in preschool children with cystic fibrosis (CF) diagnosed following newborn screening.184 children (aged 3-6 years) with CF underwent lung function testing on 422 occasions using the FOT to assess respiratory resistance and reactance at the time of their annual bronchoalveolar lavage collection and chest computed tomography scan. We examined associations between FOT outcomes and the presence and progression of respiratory inflammation, infection and structural lung disease.Children with CF who had pronounced respiratory disease, including free neutrophil elastase activity, infection with pro-inflammatory pathogens and structural lung abnormalities had similar FOT outcomes to those children without detectable lung disease. In addition, the progression of lung disease over 1 year was not associated with worsening FOT outcomes.We conclude that the forced oscillation technique is relatively insensitive to detect underlying lung disease in preschool children with CF. However, FOT may still be of value in improving our understanding of the physiological changes associated with early CF lung disease.
authors.affiliation: Telethon Kids Institute, University of Western Australia, Subiaco, Australia Cystic Fibrosis Research and Treatment Centre, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Ramsey
authors.affiliation: Murdoch Childrens Research Institute, Parkville, Australia Department of Respiratory Medicine, Royal Children's Hospital, Parkville, Australia Department of Paediatrics, University of Melbourne, Parkville, Australia.
authors.forename: Sarath C
authors.initials: SC
authors.lastname: Ranganathan
authors.affiliation: Telethon Kids Institute, University of Western Australia, Subiaco, Australia Queensland Children's Medical Research Institute, The University of Queensland, Herston, Australia.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Gangell
authors.affiliation: Telethon Kids Institute, University of Western Australia, Subiaco, Australia.
authors.forename: Lidija
authors.initials: L
authors.lastname: Turkovic
authors.affiliation: Telethon Kids Institute, University of Western Australia, Subiaco, Australia.
authors.forename: Judy
authors.initials: J
authors.lastname: Park
authors.affiliation: Murdoch Childrens Research Institute, Parkville, Australia Department of Respiratory Medicine, Royal Children's Hospital, Parkville, Australia.
authors.forename: Billy
authors.initials: B
authors.lastname: Skoric
authors.affiliation: Telethon Kids Institute, University of Western Australia, Subiaco, Australia Department of Respiratory Medicine, Princess Margaret Hospital for Children, Subiaco, Australia.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Stick
authors.affiliation: Queensland Children's Medical Research Institute, The University of Queensland, Herston, Australia.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Sly
authors.affiliation: Telethon Kids Institute, University of Western Australia, Subiaco, Australia Graham.Hall@telethonkids.org.au.
authors.forename: Graham L
authors.initials: GL
authors.lastname: Hall
mesh_terms: D000403:Airway Resistance / Q000502:physiology*; D018893:Bronchoalveolar Lavage; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000276:immunology; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008168:Lung / Q000000981:diagnostic imaging / Q000276:immunology / Q000503:physiopathology*; D008171:Lung Diseases / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D009504:Neutrophils / Q000276:immunology; D012129:Respiratory Function Tests / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8