title: mTOR in health and in sickness.
abstract: Target of rapamycin (TOR) is a highly conserved protein kinase that plays a key role in mediating cell growth and homeostasis. It is activated by nutrients, growth factors, and cellular energy levels to control a number of anabolic and catabolic processes. It is a validated drug target implicated in a variety of diseases. In this review, we describe the molecular mode of action of TOR in the context of cellular and organismal physiology. We focus on mammalian TOR (mTOR) signaling in cancer and neurological disease and discuss usage of TOR inhibitors in the clinic.
authors.affiliation: Biozentrum, University of Basel, 4056, Basel, Switzerland. dritan.liko@unibas.ch.
authors.forename: Dritan
authors.initials: D
authors.lastname: Liko
authors.affiliation: Biozentrum, University of Basel, 4056, Basel, Switzerland.
authors.forename: Michael N
authors.initials: MN
authors.lastname: Hall
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases
keywords: Disease; Health; Rapalogs; Rapamycin; TOR; mTOR; mTOR inhibitors; mTORC1; mTORC2