title: Microbiological Assessment of Polymyxin B Components Tested Alone and in Combination.
abstract: We investigated the antimicrobial activity of four polymyxin B components, B1, B2, B3, and isoleucine (Ile)-B1, individually and in combination. B3 was the most active agent against all organisms tested except Acinetobacter baumannii, for which Ile-B1 was most active. One combination met the criteria for synergy, B3 plus Ile-B1. No combinations exhibited antagonism. The dominant components of polymyxin B products (B1 and B2) were associated with the lowest probability of improved antibacterial activity when combined.
authors.affiliation: Department of Pharmaceutical Services, University of California, Los Angeles, Los Angeles, California, USA.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Kassamali
authors.affiliation: Department of Clinical Services and Administration, University of Houston, Houston, Texas, USA.
authors.forename: Randall A
authors.initials: RA
authors.lastname: Prince
authors.affiliation: Colleges of Pharmacy and Medicine, University of Illinois at Chicago, Chicago, Illinois, USA danziger@uic.edu.
authors.forename: Larry H
authors.initials: LH
authors.lastname: Danziger
authors.affiliation: Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Rotschafer
authors.affiliation: JMI Laboratories, North Liberty, Iowa, USA.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Rhomberg
authors.affiliation: JMI Laboratories, North Liberty, Iowa, USA.
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects / Q000254:growth & development; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002210:Caprylates / Q000737:chemistry*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002210:Caprylates; D011112:Polymyxin B