title: TELOMERE AND TELOMERASE MODULATION BY BERGAMOT POLYPHENOLIC FRACTION IN EXPERIMENTAL PHOTOAGEING IN HUMAN KERATINOCYTES.
abstract: Photoageing represents the addition of extrinsic chronic ultraviolet radiation-induced damage on intrinsic ageing and accounts for most age-associated changes in skin appearance. In this study, we evaluated the effect of 38% BPF, a highly concentrated extract of the bergamot fruit (Citrus bergamia) on UVB-induced photoageing by examining inflammatory cytokine expression, telomere length/telomerase alterations and cellular viability in human immortalized HaCaT keratinocytes. Our results suggest that 38% BPF protects HaCaT cells against UVB-induced oxidative stress and markers of photoageing in a dose-dependent manner and could be a useful supplement in skin care products. Together with antioxidant properties, BPF, a highly concentrated extract of the bergamot fruit, appears to modulate basic cellular signal transduction pathways leading to anti-proliferative, anti-aging and immune modulating responses.
authors.affiliation: Department of Health Sciences; University of Catanzaro Magna Graecia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Nisticò
authors.affiliation: Interregional Research Center For Food Safety and Health, Department of Health Sciences, University of Catanzaro Magna Graecia, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Ehrlich
authors.affiliation: School of Pharmacy; University of Catanzaro Magna Graecia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gliozzi
authors.affiliation: School of Pharmacy; University of Catanzaro Magna Graecia, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Maiuolo
authors.affiliation: Department of Health Sciences; University of Catanzaro Magna Graecia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Del Duca
authors.affiliation: School of Pharmacy; University of Catanzaro Magna Graecia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Muscoli
authors.affiliation: Interregional Research Center For Food Safety and Health, Department of Health Sciences, University of Catanzaro Magna Graecia, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Mollace
mesh_terms: D002461:Cell Line, Transformed; D002957:Citrus / Q000737:chemistry*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology*; D015595:Skin Aging / Q000187:drug effects / Q000528:radiation effects; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D059808:Polyphenols; D019098:Telomerase