title: Age-Stratified Prevalence of Mild Cognitive Impairment and Dementia in European Populations: A Systematic Review.
abstract: The prevalence of mild cognitive impairment (MCI) and dementia according to age remain uncertain. We systematically extracted age-stratified estimates of MCI and dementia prevalence reported in European studies published since 1995, and performed meta-analyses for dementia. We identified 10 relevant studies on MCI and 26 studies on dementia. Studies on MCI presented substantial heterogeneity preventing a meta-analysis, with a majority reporting an increase in prevalence at ≥75 years old. Pooled prevalence of dementia rose continuously from 55 years of age, reaching 44.7% (39.8; 49.6) in those ≥95 years of age. Homogenization of MCI criteria, and additional studies in Northern European population would be warranted.
authors.affiliation: Roche Products Limited, Hexagon Place, 6 Falcon way, Shire Park, Welwyn Garden City, UK.
authors.forename: Myriam
authors.initials: M
authors.lastname: Alexander
authors.affiliation: Roche Products Limited, Hexagon Place, 6 Falcon way, Shire Park, Welwyn Garden City, UK.|Institute of Psychiatry, King's College London, De Crespigny Park, London, UK.
authors.forename: Gayan
authors.initials: G
authors.lastname: Perera
authors.affiliation: Janssen Pharmaceutical Research and Development, Titusville, NJ, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Ford
authors.affiliation: Janssen Research & Development, LLC, Fremont, CA, USA.
authors.forename: H Michael
authors.initials: HM
authors.lastname: Arrighi
authors.affiliation: Roche Products Limited, Hexagon Place, 6 Falcon way, Shire Park, Welwyn Garden City, UK.
authors.forename: Nadia
authors.initials: N
authors.lastname: Foskett
authors.affiliation: Boehringer Ingelheim, Reims, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Debove
authors.affiliation: Janssen Pharmaceutical Research and Development, Titusville, NJ, USA.
authors.forename: Gerald
authors.initials: G
authors.lastname: Novak
authors.affiliation: Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
authors.forename: Mark Forrest
authors.initials: MF
authors.lastname: Gordon
mesh_terms: D000367:Age Factors; D060825:Cognitive Dysfunction / Q000453:epidemiology*; D003704:Dementia / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D006801:Humans; D015995:Prevalence
keywords: Dementia; epidemiology; mild cognitive impairment; prevalence