title: Glyconanomaterials for Combating Bacterial Infections.
abstract: Bacterial infections constitute an increasing problem to human health in response to build-up of resistance to present antibiotics and sluggish development of new pharmaceuticals. However, a means to address this problem is to pinpoint the drug delivery to-and into-the bacteria. This results in a high local concentration of the drug, circumventing the increasingly high doses otherwise necessary. Combined with other effectors, such as covalent attachment to carriers, rendering the drugs less degradable, and the combination with efflux inhibitors, old drugs can be revived. In this context, glyconanomaterials offer exceptional potential, since these materials can be tailored to accommodate different effectors. In this Concept article, we describe the different advantages of glyconanomaterials, and point to their potential in antibiotic "revitalization".
authors.affiliation: Department of Chemistry, KTH - Royal Institute of Technology, Stockholm (Sweden). ramstrom@kth.se.
authors.forename: Olof
authors.initials: O
authors.lastname: Ramström
authors.affiliation: Department of Chemistry, KTH - Royal Institute of Technology, Stockholm (Sweden). Mingdi_Yan@uml.edu.|Department of Chemistry, University of Massachusetts Lowell, Lowell, MA (USA). Mingdi_Yan@uml.edu.
authors.forename: Mingdi
authors.initials: M
authors.lastname: Yan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000737:chemistry* / Q000187:drug effects*; D001424:Bacterial Infections; D016503:Drug Delivery Systems; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibiotics; carbohydrates; materials science; nanostructures; supramolecular chemistry