title: Individual participant data meta-analysis of primary laryngeal lymphoma: Focusing on the clinical characteristics and prognosis.
abstract: OBJECTIVE
  Primary lymphoma of the larynx is rare. The symptoms are ambiguous and nonspecific, and confirmation of the diagnosis is often difficult. To better understand the clinical characteristics of this distressing disease, we performed an individual participant data meta-analysis focusing on the diagnoses and treatment outcomes.
  
  
  METHODS
  Systematic review article.
  
  
  METHODS
  A literature search of the MEDLINE, Embase, and Cochrane library databases was conducted using the following Medical Subject Headings and keywords: "primary," "lymphoma," "cancer," and "larynx." The individual data of 57 patients from 41 articles were selected based on the inclusion criteria for the analysis.
  
  
  RESULTS
  The mean age of the 57 patients at the time of diagnosis was 53.9 ± 18 years, and there was a preponderance of male patients (male:female = 35:22). The mean follow-up was 33.2 ± 40.5 months. The most common symptom was hoarseness (70.2%). Extension of the lymphoma was found in the supraglottic larynx (63.2%). B-symptoms were noted in only 14.0% of patients. The treatment method and disease extent were not significant factors. The significant prognostic factors were the biopsy frequency (P = .000), B-symptoms (P = .032), and cell type (P < .001).
  
  
  CONCLUSIONS
  From an analysis of larynx lymphoma patients, accurate biopsy, the presence of B-symptoms, and the cell type of the lymphoma are important to the prognosis. However, the treatment method was not effective in predicting the prognosis.
  
  
  METHODS
  NA.
authors.affiliation: Department of Otolaryngology, Gyeongsang National University, Jinju.|College of Nursing, Gyeongsang National University, Jinju.
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Dong-A University Hospital Regional Cardiocerebrovascular Center (R.B.K.), Busan, South Korea.
authors.forename: Rock Bum
authors.initials: RB
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology, Gyeongsang National University, Jinju.|Institute of Health Sciences, Gyeongsang National University, Jinju.
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Woo
mesh_terms: D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D007830:Larynx / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology* / Q000628:therapy; D008297:Male; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Larynx; laryngeal neoplasm; lymphoma; prognosis; treatment