title: Do post-stroke patients benefit from robotic verticalization? A pilot-study focusing on a novel neurophysiological approach.
abstract: BACKGROUND
  Tilt-table equipped with the dynamic foot-support (ERIGO) and the functional electric stimulation could be a safe and suitable device for stabilization of vital signs, increasing patient's motivation for further recovery, decreasing the duration of hospitalization, and accelerating the adaptation to vertical posture in bedridden patients with brain-injury. Moreover, it is conceivable that verticalization may improve cognitive functions, and induce plastic changes at sensory motor and vestibular system level that may in turn facilitate motor functional recovery.
  
  
  OBJECTIVE
  To test the safety and effectiveness of ERIGO treatment on motor and cognitive functions, cortical plasticity within vestibular and sensory-motor systems in a bedridden post-stroke sample.
  
  
  METHODS
  20 patients were randomly divided in two groups that performed ERIGO training (30 sessions) (G1) or physiotherapist-assisted verticalization training (same duration) (G2), beyond conventional neurorehabilitation treatment. Motor and cognitive functions as well as sensory-motor and vestibular system plasticity were investigated either before (T0) or after (T1) the rehabilitative protocols.
  
  
  RESULTS
  Both the verticalization treatments were well-tolerated. Notably, the G1 patients had a significant improvement in cognitive function (p = 0.03), global motor function (p = 0.006), sensory-motor (p < 0.001) and vestibular system plasticity (p = 0.02) as compared to G2.
  
  
  CONCLUSIONS
  ERIGO training could be a valuable tool for the adaptation to the vertical position with a better global function improvement, as also suggested by the sensory-motor and vestibular system plasticity induction.
authors.forename: Rocco Salvatore
authors.initials: RS
authors.lastname: Calabrò
authors.forename: Antonino
authors.initials: A
authors.lastname: Naro
authors.forename: Margherita
authors.initials: M
authors.lastname: Russo
authors.forename: Antonino
authors.initials: A
authors.lastname: Leo
authors.forename: Tina
authors.initials: T
authors.lastname: Balletta
authors.forename: Ileana
authors.initials: I
authors.lastname: Saccá
authors.forename: Rosaria
authors.initials: R
authors.lastname: De Luca
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000503:physiopathology* / Q000523:psychology / Q000534:rehabilitation*; D002540:Cerebral Cortex / Q000503:physiopathology; D003071:Cognition; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D026741:Physical Therapy Modalities / Q000009:adverse effects / Q000295:instrumentation*; D010865:Pilot Projects; D011187:Posture; D020127:Recovery of Function / Q000502:physiology; D012047:Rehabilitation Centers; D012371:Robotics; D020521:Stroke / Q000503:physiopathology* / Q000523:psychology; D000071939:Stroke Rehabilitation; D016896:Treatment Outcome
keywords: ERIGO; bedridden condition; sensory-motor plasticity; stroke; verticalization; vestibular system