title: Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury.
abstract: Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3(rd) day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations. ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury.
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Physiology and Pharmacology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Siyavash
authors.initials: S
authors.lastname: Joukar
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Physiology and Pharmacology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Najafipour
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Cardiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Fateme
authors.initials: F
authors.lastname: Mirzaeipour
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Cardiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Nasri
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Mahboubeh Yeganeh Haj
authors.initials: MY
authors.lastname: Ahmadi
authors.affiliation: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Marziyeh
authors.initials: M
authors.lastname: Badinloo
keywords: arterial blood pressure; heart function; isoproterenol; myocardial injury; semelil