title: Family Perception and 6-Month Symptomatic and Functioning Outcomes in Young Adolescents at Clinical High Risk for Psychosis in a General Population in China.
abstract: Given the difficulty of treating schizophrenia and other forms of psychosis, researchers have shifted focus to early detection and intervention of individuals at clinical high risk (CHR) for psychosis. Previous studies have shown that elements in family functioning could predict symptom outcome in CHR individuals. However, associations between self reported family functioning and symptom or functioning outcome of CHR individuals was rarely reported. Our study aimed to investigate the characteristics and the role of family functioning in the development of CHR individuals among young adolescents.
  
  
  
  A sample of 32 CHR individuals was recruited from 2800 university students. The characteristics of family perception were evaluated by both Family Assessment Device (FAD) and Family cohesion and adaptability evaluation Scale II (FACES II). 6 month follow up data was available with 25 of the recruited CHR individuals. Baseline socio-demographic characteristics and family functioning were compared between CHR and control group. We also measured the associations between different dimensions of perceived family functioning and both severity of prodromal symptoms and global functioning at baseline and 6-month follow up.
  
  
  
  CHR individuals showed more maladaptive family functioning compared to control in nearly all of the dimensions of FAD and FACES II except for Affective Involvement. Better Problem Solving and Affective Responsiveness predicted less severe positive and negative symptoms respectively. Family cohesion and adaptability were not only correlated with the baseline severity of general symptoms, but also positively associated with the general and disorganized symptom outcome.
  
  
  
  This study contributed preliminary evidence towards the associations between family perception and symptom outcome of CHR individuals. It also provided evidence for the importance of family interventions on CHR individuals.
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Faculty of Humanities and Behavior Medicine, Tongji University School of Medicine, Shanghai, China.
authors.forename: JingYu
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Psychosomatic Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: FaZhan
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Tongji university counseling center, Tongji University, Shanghai, China.
authors.forename: YuHong
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: ChenYu
authors.initials: C
authors.lastname: Zhan
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: XiaoWen
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: XiaoYan
authors.initials: X
authors.lastname: Fang
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: HaoJie
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: JiaBei
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China; Faculty of Humanities and Behavior Medicine, Tongji University School of Medicine, Shanghai, China.
authors.forename: XuDong
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002681:China; D003710:Demography; D005190:Family / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000473:pathology; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014175:Translating; D055815:Young Adult