title: Understanding the molecular basis of disease is crucial to improving the design and construction of herpesviral vectors for veterinary vaccines.
abstract: Viral infections are associated with production losses in many animal production industries. Important examples of this are Marek's disease (MD) and bovine respiratory disease (BRD) which are significant issues in the chicken and cattle industries, respectively. Viruses play key roles in MD and BRD development and consequently have also been utilised in vaccination strategies to control these diseases. Despite the widespread availability and use of vaccines to control these diseases both are still major issues for their respective industries. Here the dual role of members of viruses from the family Herpesviridae in causation and control of MD and BRD will be discussed. The technologies that may lead to the development of improved vaccines to provide more sustainable control of MD and BRD will also be identified.
authors.affiliation: The University of Queensland, Queensland Alliance for Agriculture and Food Innovation (QAAFI), Centre for Animal Science, Level 3 Ritchie Building, Research Road, Brisbane 4072, QLD, Australia. Electronic address: t.mahony@uq.edu.au.
authors.forename: T J
authors.initials: TJ
authors.lastname: Mahony
mesh_terms: D000818:Animals; D002417:Cattle; D002645:Chickens; D055808:Drug Discovery / Q000379:methods; D006564:Herpesviridae / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D022283:Herpesvirus Vaccines / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*; D007241:Infectious Bovine Rhinotracheitis / Q000517:prevention & control / Q000821:virology*; D008380:Marek Disease / Q000517:prevention & control / Q000821:virology*; D014730:Veterinary Medicine / Q000379:methods*
chemical_list: D022283:Herpesvirus Vaccines
keywords: Bovine herpesvirus 1; Bovine respiratory disease; Gallid herpesvirus 2; Marek's disease; Meleagrid herpesvirus 1; Veterinary vaccine