title: New platinum(II)-bipyridyl corrole complexes: Synthesis, characterization and binding studies with DNA and HSA.
abstract: A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure.
authors.affiliation: Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal; Departament of Chemistry, Universidade Federal de Santa Catarina, UFSC, 88040-970 Florianópolis, SC, Brazil; Departamento de Química, Universidade Federal de Santa Maria, UFSM, 97115-900 Santa Maria, RS, Brazil.
authors.forename: Bernardo A
authors.initials: BA
authors.lastname: Iglesias
authors.affiliation: Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal; CICECO Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: jbarata@ua.pt.
authors.forename: Joana F B
authors.initials: JFB
authors.lastname: Barata
authors.affiliation: Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal; Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
authors.forename: Patrícia M R
authors.initials: PMR
authors.lastname: Pereira
authors.affiliation: Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Portugal.
authors.forename: Henrique
authors.initials: H
authors.lastname: Girão
authors.affiliation: Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal; Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Portugal; Center of Investigation in Environment, Genetics and Oncobiology, 3001-301 Coimbra, Portugal.
authors.forename: Rosa
authors.initials: R
authors.lastname: Fernandes
authors.affiliation: Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal; Department of Organic and Macromolecular Chemistry, Ghent University, B-9000 Gent, Belgium.
authors.forename: João P C
authors.initials: JPC
authors.lastname: Tomé
authors.affiliation: Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: gneves@ua.pt.
authors.forename: Maria G P M S
authors.initials: MGPMS
authors.lastname: Neves
authors.affiliation: Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal.
authors.forename: José A S
authors.initials: JAS
authors.lastname: Cavaleiro
mesh_terms: D015082:2,2'-Dipyridyl / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D004587:Electrophoresis, Agar Gel; D006801:Humans; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D012709:Serum Albumin / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D009944:Organoplatinum Compounds; D011166:Porphyrins; D012709:Serum Albumin; D015082:2,2'-Dipyridyl; D004247:DNA; C427203:calf thymus DNA
keywords: Corroles; Deoxyribonucleic acid (DNA); Human serum albumin (HSA); Plasmid DNA (pDNA); Platinum(II) complexes; trans-A(2)B corroles