title: Allergic Rhinitis in Children: A Randomized Clinical Trial Targeted at Symptoms.
abstract: Allergic rhinitis (AR) underlies many symptoms and complications which severely affect children's quality of life. This two-arm study aimed at evaluate the efficacy and safety of the medical device Narivent(®) versus topical corticosteroids in the symptomatic management of allergic rhinitis in paediatric patients. A randomized study was conducted. Forty subjects with a diagnosis of allergic rhinitis were randomized to receive one puff of Narivent(®) into each nostril twice daily for 30 days (n = 20) or to receive one puff of topical intranasal corticosteroid into each nostril twice daily for 30 days (n = 20). In both treatment arms, severity of major symptoms related to AR, including nasal congestion, rhinorrhoea, sneezing and nasal itching, was assessed subjectively on a 0-100 mm visual analogue scale. Nasal congestion, rhinorrhoea and sneezing improved significantly after 30 days of treatment with Narivent(®). Similarly, in topical steroids group severity of all subjective symptoms decreased significantly. Narivent(®) appears to be efficacious in treating nasal congestion and other major symptoms in children with AR over a 30-day period, showing comparable results to intranasal corticosteroids therapy but with a better safety profile.
authors.affiliation: S.C. di Otorinolaringoiatria della A.O.R.N. Santobono Pausilipon di Napoli, Naples, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Mansi
authors.affiliation: S.C. di Otorinolaringoiatria della A.O.R.N. Santobono Pausilipon di Napoli, Naples, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: D'Agostino
authors.affiliation: Zeta Research Srl, Trieste, Italy.
authors.forename: Antonella Silvia
authors.initials: AS
authors.lastname: Scirè
authors.affiliation: Zeta Research Srl, Trieste, Italy.
authors.forename: Giada
authors.initials: G
authors.lastname: Morpurgo
authors.affiliation: Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Via Loredan, 18, 35121 Padua, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Gregori
authors.affiliation: E.N.T. Department, Maulana Azad Medical College and LN, New Delhi, India.
authors.forename: Achal
authors.initials: A
authors.lastname: Gulati
authors.affiliation: ENT Department San Giovanni Addolorata Hospital, Rome, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Damiani
keywords: Allergic rhinitis; Anti-inflammatory; Anti-oedematous; Children; Intranasal corticosteroids; Osmotically-acting medical device