title: [Pattern of lymphatic metastasis and risk factor of esophageal carcinoma that invades less than adventitia].
abstract: OBJECTIVE
  To explore the pattern of lymphatic metastasis and risk factors of esophageal carcinoma that invades less than adventitia.
  
  
  METHODS
  Clinical data of 484 patients receiving esophagectomy from January 2011 to August 2014 were reviewed, whose carcinoma invaded less than adventitia. The lymph node metastasis pattern of the primary tumor and corresponding influence factor were analyzed.
  
  
  RESULTS
  Total lymph node metastatic rate was 32.0% (155/484). Sixteen of 61 upper thoracic esophageal carcinoma patients (26.2%) had lymphatic metastasis. Fifty-five of 201 middle thoracic esophageal carcinoma patients (27.4%) had lymphatic metastasis. Eighty-four of 222 lower thoracic esophageal carcinoma patients(37.8%) had lymphatic metastasis. The deeper tumor invaded, the easier lymph node metastasis occurred, as well as the lower of the tumor differentiation and the larger of the tumor diameter. Multivariate analysis revealed lesion diameter (P=0.005), differentiation degree (P=0.007) and invasion depth (P=0.001) were independent risk factors of lymphatic metastasis in esophageal cancer that invaded less than adventitia.
  
  
  CONCLUSIONS
  Depth of tumor invasion, diameter of tumor and tumor differentiation are risk factors of lymph node metastasis of esophageal carcinoma that invades less than adventitia.
authors.affiliation: Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. gaoshugeng@sina.vip.com.
authors.forename: Moyan
authors.initials: M
authors.lastname: Zhang
authors.forename: Ruochuan
authors.initials: R
authors.lastname: Zang
authors.forename: Wendong
authors.initials: W
authors.lastname: Lei
authors.forename: Qi
authors.initials: Q
authors.lastname: Xue
authors.forename: Shugeng
authors.initials: S
authors.lastname: Gao
mesh_terms: D063194:Adventitia / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000473:pathology*; D016629:Esophagectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors