title: Tubulointerstitial Nephritis and Uveitis Syndrome: Case Report and Review of the Literature.
abstract: OBJECTIVE
  To review the literature on tubulointerstitial nephritis and uveitis (TINU) syndrome, and to report a case of a patient with relapsing polychondritis (RP) and TINU syndrome.
  
  
  METHODS
  TINU syndrome is a rare oculorenal inflammatory disorder. It is more common in young women with autoimmune conditions, infections, systemic disease, and previous use of medications. We report the case of a 62-year-old woman with relapsing polychondritis and a 2-year history of acute, recurrent, asymmetric, bilateral, anterior, non-granulomatous uveitis accompanied by tubulointerstitial nephritis.
  
  
  RESULTS
  The patient was diagnosed with TINU syndrome associated with relapsing polychondritis. No cases of this association have been reported in the literature. The clinical features of TINU syndrome are discussed based on the published works.
  
  
  CONCLUSIONS
  TINU is an uncommon syndrome; only about 200 cases have been reported in the literature related to infections, systemic disease, and previous use of medications such as antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). We found that it can be associated with relapsing polychondritis; therefore, it is important to investigate symptoms of this disease since TINU syndrome can co-exist with it.
authors.affiliation: a Uveitis Service, Fundación Oftalmológica Nacional, Rosario University , Bogotá , Colombia and.
authors.forename: María Camila
authors.initials: MC
authors.lastname: Aguilar
authors.affiliation: a Uveitis Service, Fundación Oftalmológica Nacional, Rosario University , Bogotá , Colombia and.
authors.forename: Marcela
authors.initials: M
authors.lastname: Lonngi
authors.affiliation: a Uveitis Service, Fundación Oftalmológica Nacional, Rosario University , Bogotá , Colombia and.|b School of Medicine and Health Science, Study Group on Public Health, Immunology Service, Rosario University , Bogotá , Colombia.
authors.forename: Alejandra
authors.initials: A
authors.lastname: de-la-Torre
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011081:Polychondritis, Relapsing / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids
keywords: Acute tubulointerstitial nephritis; TINU syndrome; nephropathy; relapsing polychondritis; uveitis