title: Morphological Changes in Rat Uterine Tissues and Possibility of Spontaneous Labor as a Result of Injection of Multipotent Mesenchymal Stromal Cells against the Background of Hydrometra.
abstract: The possibility of pregnancy and labor was evaluated and tissue changes after injection of autologous bone marrow multipotent mesenchymal stromal cells with transfected GFP gene were studied in rats with experimental hydrometra. Injection of stromal cells to the uterine cicatrix increased the number of vessels (vascular walls or their elements) formed de novo with participation of injected cells. The animals produced progeny 2 estrous cycles earlier, the percentage of "puerperal" rats in this group was higher, their progeny was more numerous and they had the maximum numbers of little rats. The maternal mortality was lower after injection of stromal cells. Injection of stromal cells led to development of a trend to more rapid reparative processes in the uterus in animals with cicatricial stenosis of its lumen.
authors.affiliation: Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. imai@mail.ru.
authors.forename: I V
authors.initials: IV
authors.lastname: Maiborodin
authors.affiliation: Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Onoprienko
authors.affiliation: Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Chastikin
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000473:pathology; D005260:Female; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology; D018919:Neovascularization, Physiologic; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014591:Uterine Diseases / Q000628:therapy*; D014599:Uterus / Q000098:blood supply / Q000473:pathology*
keywords: angiogenesis; autologous bone marrow multipotent mesenchymal stromal cells; hydrometra; uterine cicatrix