title: Free energy cost of reducing noise while maintaining a high sensitivity.
abstract: Living systems need to be highly responsive, and also to keep fluctuations low. These goals are incompatible in equilibrium systems due to the fluctuation dissipation theorem (FDT). Here, we show that biological sensory systems, driven far from equilibrium by free energy consumption, can reduce their intrinsic fluctuations while maintaining high responsiveness. By developing a continuum theory of the E. coli chemotaxis pathway, we demonstrate that adaptation can be understood as a nonequilibrium phase transition controlled by free energy dissipation, and it is characterized by a breaking of the FDT. We show that the maximum response at short time is enhanced by free energy dissipation. At the same time, the low frequency fluctuations and the adaptation error decrease with the free energy dissipation algebraically and exponentially, respectively.
authors.affiliation: Max Planck Institute for the Physics of Complex Systems, Noethnitzer Strasse 38, 01187 Dresden, Germany.
authors.forename: Pablo
authors.initials: P
authors.lastname: Sartori
authors.affiliation: IBM T.J. Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, New York 10598, USA.
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Tu
mesh_terms: D000220:Adaptation, Biological; D005246:Feedback; D016014:Linear Models; D008954:Models, Biological; D008956:Models, Chemical; D008962:Models, Theoretical; D009622:Noise; D013816:Thermodynamics