title: An Optimization-Driven Analysis Pipeline to Uncover Biomarkers and Signaling Paths: Cervix Cancer.
abstract: Establishing how a series of potentially important genes might relate to each other is relevant to understand the origin and evolution of illnesses, such as cancer. High-throughput biological experiments have played a critical role in providing information in this regard. A special challenge, however, is that of trying to conciliate information from separate microarray experiments to build a potential genetic signaling path. This work proposes a two-step analysis pipeline, based on optimization, to approach meta-analysis aiming to build a proxy for a genetic signaling path.
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA.
authors.forename: Enery
authors.initials: E
authors.lastname: Lorenzo
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA.
authors.forename: Katia
authors.initials: K
authors.lastname: Camacho-Caceres
authors.affiliation: Pittsburgh Supercomputing Center, 300 S. Craig Street, Pittsburgh, PA 15213, USA.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Ropelewski
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Rosas
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Ortiz-Mojer
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: Perez-Marty
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Irizarry
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA.
authors.forename: Valerie
authors.initials: V
authors.lastname: Gonzalez
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA.
authors.forename: Jesús A
authors.initials: JA
authors.lastname: Rodríguez
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Cabrera-Rios
authors.affiliation: Bio IE Lab, The Applied Optimization Group at UPRM, Industrial Engineering Department, University of Puerto Rico at Mayaguez, Call Box 9000, Mayagüez, PR 00681, USA ; Department of Pharmacology and Toxicology, Ponce School of Medicine, PO Box 700, Ponce, PR 00732, USA.
authors.forename: Clara
authors.initials: C
authors.lastname: Isaza
keywords: cancer biology; signaling pathways; traveling salesman problem