title: A model of poststroke fatigue based on sensorimotor deficits.
abstract: OBJECTIVE
  This review examines recent studies in poststroke fatigue that might contribute in understanding the pathophysiology of poststroke fatigue. Poststroke fatigue is a common problem in stroke survivors. Little is known about the pathophysiology of chronic fatigue in stroke survivors. It has long been thought of as a neuropsychiatric problem. However, there is gathering evidence to the contrary. In this study, we propose a new model of poststroke fatigue based on recent findings of corticomotor neurophysiological, behavioural, and perceptual deficits in the poststroke fatigue population.
  
  
  CONCLUSIONS
  The current evidence suggests that poststroke fatigue may not be a neuropsychiatric problem but a problem of the sensorimotor system. Future studies need to address the causal link between sensorimotor deficits and poststroke fatigue.
authors.affiliation: aSobell Department of Motor Neuroscience, UCL Institute of Neurology bThe National Hospital for Neurology and Neurosurgery cUCLPartners Centre for Neurorehabilitation, London, UK.
authors.forename: Annapoorna
authors.initials: A
authors.lastname: Kuppuswamy
authors.forename: John
authors.initials: J
authors.lastname: Rothwell
authors.forename: Nick
authors.initials: N
authors.lastname: Ward
mesh_terms: D005221:Fatigue / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D008959:Models, Neurological; D066191:Sensorimotor Cortex / Q000503:physiopathology*; D020521:Stroke / Q000150:complications*