title: [Bone Cell Biology Assessed by Microscopic Approach. The effect of parathyroid hormone and teriparatide on bone].
abstract: Continuous exposure to parathyroid hormone (PTH) leads to hypercalcemia and a decrease in bone volume, which is referred to as its catabolic effect, while intermittent exogenously administered PTH leads to an anabolic effect on bone. Intermittent administration of PTH dramatically increases bone remodeling and modeling through their direct and indirect effects on the functional cells of bone remodeling units and their precursors. These effects on bone metabolism differ according to dosing frequency of PTH. Therefore, different dosing frequency of PTH shows different therapeutic effects on bone in terms of bone volume and bone quality in patients with osteoporosis.
authors.affiliation: Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takahata
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002454:Cell Differentiation; D006801:Humans; D010011:Osteocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010012:Osteogenesis; D010281:Parathyroid Hormone / Q000494:pharmacology*; D019379:Teriparatide / Q000494:pharmacology*
chemical_list: D010281:Parathyroid Hormone; D019379:Teriparatide