title: Block versus Random Amphiphilic Glycopolymer Nanopaticles as Glucose-Responsive Vehicles.
abstract: To explore the effect of polymer structure on their self-assembled aggregates and their unique characteristics, this study was devoted to developing a series of amphiphilic block and random phenylboronic acid-based glycopolymers by RAFT polymerization. The amphiphilic glycopolymers were successfully self-assembled into spherically shaped nanoparticles with narrow size distribution in aqueous solution. For block and random copolymers with similar monomer compositions, block copolymer nanoparticles exhibited a more regular transmittance change with the increasing glucose level, while a more evident variation of size and quicker decreasing tendency in I/I0 behavior in different glucose media were observed for random copolymer nanoparticles. Cell viability of all the polymer nanoparticles investigated by MTT assay was higher than 80%, indicating that both block and random copolymers had good cytocompatibility. Insulin could be encapsulated into both nanoparticles, and insulin release rate for random glycopolymer was slightly quicker than that for the block ones. We speculate that different chain conformations between block and random glycopolymers play an important role in self-assembled nanoaggregates and underlying glucose-sensitive behavior.
authors.affiliation: Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Tianqi
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Jinxia
authors.initials: J
authors.lastname: An
authors.affiliation: 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital, Tianjin Medical University , Tianjin 300070, China.
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Dai
authors.affiliation: Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Xinge
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Chaoxing
authors.initials: C
authors.lastname: Li
mesh_terms: D005947:Glucose / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers; D005947:Glucose