title: In Vitro Activities of Ceftazidime-Avibactam, Aztreonam-Avibactam, and a Panel of Older and Contemporary Antimicrobial Agents against Carbapenemase-Producing Gram-Negative Bacilli.
abstract: Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC, 32 NDM, 11 IMP, 8 OXA-48, 4 OXA-181, 2 OXA-232, 5 IMI, 4 VIM, and 3 SME producers), aztreonam-avibactam was active against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC-, IMI-, SME-, and most OXA-48 group-producing isolates (93%) but not metallo-β-lactamase producers. Among older and contemporary antimicrobials, the most active were colistin, tigecycline, and fosfomycin, with overall susceptibilities of 88%, 79%, and 78%, respectively.
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA Department of Infectious Diseases, Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore.
authors.forename: Shawn
authors.initials: S
authors.lastname: Vasoo
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Cunningham
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Nicolynn C
authors.initials: NC
authors.lastname: Cole
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Peggy C
authors.initials: PC
authors.lastname: Kohner
authors.affiliation: Clinical Microbiology, Department of Laboratory Medicine, Tan Tock Seng Hospital Singapore.
authors.forename: Sanjay R
authors.initials: SR
authors.lastname: Menon
authors.affiliation: Forest Research Institute, Inc., Jersey City, New Jersey, USA.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Krause
authors.affiliation: Forest Research Institute, Inc., Jersey City, New Jersey, USA.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Harris
authors.affiliation: Clinical Microbiology, Department of Laboratory Medicine, Tan Tock Seng Hospital Singapore.
authors.forename: Partha P
authors.initials: PP
authors.lastname: De
authors.affiliation: Department of Pathology, Singapore General Hospital, Singapore.
authors.forename: Tse Hsien
authors.initials: TH
authors.lastname: Koh
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA patel.robin@mayo.edu.
authors.forename: Robin
authors.initials: R
authors.lastname: Patel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D053961:Azabicyclo Compounds / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D002442:Ceftazidime / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology; D004338:Drug Combinations; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000254:growth & development; D005578:Fosfomycin / Q000494:pharmacology; D015870:Gene Expression; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D000078304:Tigecycline; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D001426:Bacterial Proteins; D004338:Drug Combinations; C000595613:avibactam, ceftazidime drug combination; D005578:Fosfomycin; D000078304:Tigecycline; C543519:avibactam; D002442:Ceftazidime; D001618:beta-Lactamases; C063912:carbapenemase; D008911:Minocycline; D001398:Aztreonam; D003091:Colistin