title: Characteristics of Neovascular Age-Related Macular Degeneration in Brazilian Patients.
abstract: OBJECTIVE
  To report features of neovascular age-related macular degeneration (AMD) in Brazilian patients.
  
  
  METHODS
  Data were prospectively collected from patients diagnosed with neovascular AMD. Eyes were classified as having typical neovascular AMD, polypoidal choroidal vasculopathy (PCV), or retinal angiomatous proliferation (RAP).
  
  
  RESULTS
  In total, 265 eyes of 207 patients of predominantly Caucasian ancestry were included; 166 (62.6%) eyes had typical neovascular AMD, 65 (24.5%) eyes had PCV, and 34 (12.8%) eyes had RAP. RAP demonstrated a higher percentage of bilateral cases (p = 0.015). The mean foveal subfield thickness was significantly lower in eyes with PCV (p < 0.001). Cases with typical neovascular AMD had a higher percentage of predominantly classic and minimally classic lesions on fluorescein angiography (FA; p = 0.005).
  
  
  CONCLUSIONS
  In Brazilian patients, PCV and RAP represented 24.5 and 12.8% of neovascular AMD cases. Neovascular AMD subtypes differ in relation to clinical features, mean foveal subfield thickness and FA presentation.
authors.affiliation: Department of Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Frederico Braga
authors.initials: FB
authors.lastname: Pereira
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Veloso
authors.forename: Gregg T
authors.initials: GT
authors.lastname: Kokame
authors.forename: Márcio B
authors.initials: MB
authors.lastname: Nehemy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D011446:Prospective Studies; D015861:Retinal Neovascularization / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity; D057135:Wet Macular Degeneration / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A