title: Genome Wide Association Analysis Reveals New Production Trait Genes in a Male Duroc Population.
abstract: In this study, 796 male Duroc pigs were used to identify genomic regions controlling growth traits. Three production traits were studied: food conversion ratio, days to 100 KG, and average daily gain, using a panel of 39,436 single nucleotide polymorphisms. In total, we detected 11 genome-wide and 162 chromosome-wide single nucleotide polymorphism trait associations. The Gene ontology analysis identified 14 candidate genes close to significant single nucleotide polymorphisms, with growth-related functions: six for days to 100 KG (WT1, FBXO3, DOCK7, PPP3CA, AGPAT9, and NKX6-1), seven for food conversion ratio (MAP2, TBX15, IVL, ARL15, CPS1, VWC2L, and VAV3), and one for average daily gain (COL27A1). Gene ontology analysis indicated that most of the candidate genes are involved in muscle, fat, bone or nervous system development, nutrient absorption, and metabolism, which are all either directly or indirectly related to growth traits in pigs. Additionally, we found four haplotype blocks composed of suggestive single nucleotide polymorphisms located in the growth trait-related quantitative trait loci and further narrowed down the ranges, the largest of which decreased by ~60 Mb. Hence, our results could be used to improve pig production traits by increasing the frequency of favorable alleles via artificial selection.
authors.affiliation: Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, MOA Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China.
authors.forename: Kejun
authors.initials: K
authors.lastname: Wang
authors.affiliation: Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, 510642, People's Republic of China.
authors.forename: Dewu
authors.initials: D
authors.lastname: Liu
authors.affiliation: Research Methods Group| Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), 60 Musk Ave/cnr. Blamey St, Kelvin Grove, QLD 4059, Australia.
authors.forename: Jules
authors.initials: J
authors.lastname: Hernandez-Sanchez
authors.affiliation: Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, MOA Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, MOA Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China.
authors.forename: Chengkun
authors.initials: C
authors.lastname: Liu
authors.affiliation: Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, 510642, People's Republic of China.
authors.forename: Zhenfang
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, MOA Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China.
authors.forename: Meiying
authors.initials: M
authors.lastname: Fang
authors.affiliation: State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, 100094, People's Republic of China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
mesh_terms: D000818:Animals; D055106:Genome-Wide Association Study; D006239:Haplotypes; D008297:Male; D008460:Meat / Q000032:analysis*; D008462:Meat-Packing Industry; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D025341:Principal Component Analysis; D040641:Quantitative Trait Loci / Q000235:genetics; D034421:Sus scrofa / Q000235:genetics* / Q000254:growth & development*