title: HERITABILITY OF BRAIN NETWORK TOPOLOGY IN 853 TWINS AND SIBLINGS.
abstract: Anatomical brain networks change throughout life and with diseases. Genetic analysis of these networks may help identify processes giving rise to heritable brain disorders, but we do not yet know which network measures are promising for genetic analyses. Many factors affect the downstream results, such as the tractography algorithm used to define structural connectivity. We tested nine different tractography algorithms and four normalization methods to compute brain networks for 853 young healthy adults (twins and their siblings). We fitted genetic structural equation models to all nine network measures, after a normalization step to increase network consistency across tractography algorithms. Probabilistic tractography algorithms with global optimization (such as Probtrackx and Hough) yielded higher heritability statistics than "greedy" algorithms (such as FACT) which process small neighborhoods at each step. Some global network measures (probtrackx-derived GLOB and ST) showed significant genetic effects, making them attractive targets for genome-wide association studies.
authors.affiliation: Dept. of Neurology, University of California, Los Angeles, CA 90095, USA ; Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA.
authors.forename: L
authors.initials: L
authors.lastname: Zhan
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA.
authors.forename: N
authors.initials: N
authors.lastname: Jahanshad
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA.
authors.forename: J
authors.initials: J
authors.lastname: Faskowitz
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA.
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA.
authors.forename: G
authors.initials: G
authors.lastname: Prasad
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
authors.forename: N G
authors.initials: NG
authors.lastname: Martin
authors.affiliation: School of Psychology, University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: G I
authors.initials: GI
authors.lastname: de Zubicaray
authors.affiliation: Centre for Advanced Imaging, University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: K L
authors.initials: KL
authors.lastname: McMahon
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Wright
authors.affiliation: Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Thompson
keywords: Brain Network; ICC; Normalization; Tractography; diffusion MRI