title: Clinical Outcomes in Early-stage NSCLC Treated with Stereotactic Body Radiotherapy Versus Surgical Resection.
abstract: BACKGROUND
  Surgical resection is the treatment of first choice for patients with stage I-II non-small cell lung cancer (NSCLC). However, stereotactic body radiotherapy (SBRT) has been shown to be a good alternative treatment.
  
  
  METHODS
  Overall survival (OS), progression-free survival (PFS) and recurrence rates were compared between patients with stage I-II NSCLC treated with SBRT (n=53) and those treated with surgical resection (n=175). The propensity score method was used to correct for confounding by indication.
  
  
  RESULTS
  Before correction, the OS and PFS rates at 1 and 3 years were significantly different between SBRT and surgery, in favor of surgery. After correction, the OS and PFS after SBRT were not significantly different compared to surgery. The recurrence rates for the two treatments were also similar both before and after correction.
  
  
  CONCLUSIONS
  This retrospective study showed that clinical outcomes after SBRT are equal to those after surgery in patients with stage I-II NSCLC.
authors.affiliation: Department of Pulmonology, St. Antonius Hospital, Nieuwegein, the Netherlands.
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Kastelijn
authors.affiliation: Department of Radiotherapy, University Medical Centre Utrecht, Utrecht, the Netherlands.
authors.forename: Sherif Y
authors.initials: SY
authors.lastname: El Sharouni
authors.affiliation: Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands.
authors.forename: Frederik N
authors.initials: FN
authors.lastname: Hofman
authors.affiliation: Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands.
authors.forename: Bart P
authors.initials: BP
authors.lastname: Van Putte
authors.affiliation: Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the Netherlands.
authors.forename: Evelyn M
authors.initials: EM
authors.lastname: Monninkhof
authors.affiliation: Department of Radiotherapy, University Medical Centre Utrecht, Utrecht, the Netherlands.
authors.forename: Marco
authors.initials: M
authors.lastname: Van Vulpen
authors.affiliation: Department of Pulmonology, St. Antonius Hospital, Nieuwegein, the Netherlands f.schramel@antoniusziekenhuis.nl.
authors.forename: Franz M N H
authors.initials: FM
authors.lastname: Schramel
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000368:Aged; D018287:Carcinoma, Large Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000401:mortality*; D011379:Prognosis; D016634:Radiosurgery / Q000401:mortality*; D012189:Retrospective Studies; D015996:Survival Rate; D013908:Thoracotomy / Q000401:mortality*
keywords: Non-small cell lung cancer; clinical outcome; stage I-II; stereotactic body radiotherapy; surgery