title: Stereotactic Radiotherapy in the Treatment of Lung Metastases from Bone and Soft-tissue Sarcomas.
abstract: BACKGROUND
  The purpose of this study was to evaluate local control and toxicity in a group of patients treated with stereotactic body radiotherapy (SBRT) for lung metastases (LM) from bone and soft tissue sarcomas.
  
  
  METHODS
  From October 2010 to July 2014, patients with LM from sarcomas not suitable for surgery were treated with daily cone-beam computed tomography-guided SBRT. The dose administered ranged from 30 to 60 Gy in 3-8 fractions. Acute and late toxicity were scored according to Common Terminology Criteria for Adverse Events version 4.0.
  
  
  RESULTS
  A total of 24 patients with 68 LM from sarcomas were treated with SBRT. The median follow-up after SBRT was 17 months (range=11-51 months). Two-year actuarial lesion local control and overall survival were 85.9% and 66.4%, respectively. No G3 or greater acute and late toxicities were observed.
  
  
  CONCLUSIONS
  SBRT is a safe and effective treatment for LM from sarcoma and might be used as an alternative option in patients unfit for surgery.
authors.affiliation: Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy rezarta.frakulli@gmail.com.
authors.forename: Rezarta
authors.initials: R
authors.lastname: Frakulli
authors.affiliation: Radiation Oncology Unit, Bellaria Hospital, Bologna, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Salvi
authors.affiliation: Radiation Oncology Unit, Bellaria Hospital, Bologna, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Balestrini
authors.affiliation: Radiation Oncology Unit, Bellaria Hospital, Bologna, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Parisi
authors.affiliation: Medical Physics Unit, Bellaria Hospital, Bologna, Italy.
authors.forename: Marcella
authors.initials: M
authors.lastname: Palombarini
authors.affiliation: Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Cammelli
authors.affiliation: General and Thoracic Surgery, Rizzoli Orthopaedic Institute, Bologna, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Rocca
authors.affiliation: General and Thoracic Surgery, Rizzoli Orthopaedic Institute, Bologna, Italy.
authors.forename: Mariacristina
authors.initials: M
authors.lastname: Salone
authors.affiliation: Department of Oncology, Rizzoli Orthopaedic Institute, Bologna, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Longhi
authors.affiliation: Department of Oncology, Rizzoli Orthopaedic Institute, Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrari
authors.affiliation: Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
authors.forename: Alessio G
authors.initials: AG
authors.lastname: Morganti
authors.affiliation: Radiation Oncology Unit, Bellaria Hospital, Bologna, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Frezza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D054893:Cone-Beam Computed Tomography; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011183:Postoperative Complications; D011379:Prognosis; D016634:Radiosurgery / Q000401:mortality*; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D055815:Young Adult
keywords: SBRT; lung metastases; sarcoma