title: Human pancreas development.
abstract: A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.
authors.affiliation: Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, UK Endocrinology Department, Central Manchester University Hospitals NHS Foundation Trust, Grafton St, Manchester M13 9WU, UK rachel.jennings@manchester.ac.uk neil.hanley@manchester.ac.uk.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Jennings
authors.affiliation: Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, UK.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Berry
authors.affiliation: Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, UK.
authors.forename: James P
authors.initials: JP
authors.lastname: Strutt
authors.affiliation: Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, UK Bioinformatics Unit, Faculty of Life Science, Manchester Academic Health Science Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, UK.
authors.forename: David T
authors.initials: DT
authors.lastname: Gerrard
authors.affiliation: Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, UK Endocrinology Department, Central Manchester University Hospitals NHS Foundation Trust, Grafton St, Manchester M13 9WU, UK rachel.jennings@manchester.ac.uk neil.hanley@manchester.ac.uk.
authors.forename: Neil A
authors.initials: NA
authors.lastname: Hanley
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology*; D009024:Morphogenesis / Q000502:physiology*; D010179:Pancreas / Q000196:embryology* / Q000254:growth & development*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D013045:Species Specificity
keywords: Development; Embryo; Endoderm; Fetal; Foregut; Gestation; Human; Liver; Pancreas; Stem cells; Transcription factor; β-cells