title: Combined anti-ages and antioxidant activities of different solvent extracts of Solanum elaeagnifolium Cav (Solanacea) fruits during ripening and related to their phytochemical compositions.
abstract: Oxidative stress and advanced glycation end products (AGEs) are known as key factors for the development of diabetic complications such as retinopathy, cataract as well as atherosclerosis and neurodegenerative diseases, including Alzheimer's diseases. In this context, natural products have been previously identified as promising sources for antioxidant and anti-glycation compounds. The current study focuses on the evaluation of antioxidant and glycation inhibitory activities of different solvent extracts of Solanum elaeagnifolium Cav (Solanaceae) fruits at different ripening stages. The results showed that antioxidant and anti-AGEs activities were significantly influenced by solvents polarities and ripening stages of S. elaeagnifolium Cav. With one exception, methanolic extract of overripe S. elaeagnifolium Cav fruit showed important protective effects against cellular oxidative stress. The aqueous extract showed the highest ABTS(+) scavenging ability. Principal component analysis showed that total phenolic and flavonoid contents correlated well with observed antioxidants and anti-glycation activities. These results bring attention to the possible use of S. elaeagnifolium Cav as a valuable source of bioactive compounds exhibiting antioxidant effects and potentially alleviating diabetic complications.
authors.affiliation: Laboratory of Bioactive Substances, Biotechnology Center, Technopark of Borj-Cedria, BP 901, 2050 Hammam-Lif, Tunisia ; University of Angers, Laboratoire des Substances d'Origine Naturelle et Analogues Structuraux, SONAS-EA 921, IFR 149 QUASAV, 16 Bd Daviers, 49045 Angers, France.
authors.forename: Mejri
authors.initials: M
authors.lastname: Houda
authors.affiliation: University of Angers, Laboratoire des Substances d'Origine Naturelle et Analogues Structuraux, SONAS-EA 921, IFR 149 QUASAV, 16 Bd Daviers, 49045 Angers, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Derbré
authors.affiliation: Laboratory of Bioactive Substances, Biotechnology Center, Technopark of Borj-Cedria, BP 901, 2050 Hammam-Lif, Tunisia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Jedy
authors.affiliation: Laboratoire de Biochimie, Département de Biologie, Faculté des Sciences de Tunis, Université Tunis El-Manar, Tunis 2092, Tunisie.
authors.forename: Nizar
authors.initials: N
authors.lastname: Tlili
authors.affiliation: Laboratory LASEVE, Université du Québec a Chicoutimi, 555 Boulevard de l'Université à Chicoutimi, Québec, Canada G7H 2B1.
authors.forename: Jean
authors.initials: J
authors.lastname: Legault
authors.affiliation: University of Angers, Laboratoire des Substances d'Origine Naturelle et Analogues Structuraux, SONAS-EA 921, IFR 149 QUASAV, 16 Bd Daviers, 49045 Angers, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Richomme
authors.affiliation: Laboratory of Bioactive Substances, Biotechnology Center, Technopark of Borj-Cedria, BP 901, 2050 Hammam-Lif, Tunisia.
authors.forename: Ferid
authors.initials: F
authors.lastname: Limam
authors.affiliation: Laboratory of Bioactive Substances, Biotechnology Center, Technopark of Borj-Cedria, BP 901, 2050 Hammam-Lif, Tunisia.
authors.forename: Moufida
authors.initials: M
authors.lastname: Saidani-Tounsi
keywords: Solanum elaeagnifolium Cav; advanced glycation endproduct (AGEs); in vitro and ex-vivo antioxidant activities; phenolic compounds