title: sAβPPα Improves Hippocampal NMDA-Dependent Functional Alterations Linked to Healthy Aging.
abstract: This study shows a decrease in soluble amyloid-β protein precursor-α (sAβPPα) levels, but no change in sAβPPβ, in the rat hippocampus during healthy aging, associated with the weaker expression of N-methyl-D-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) in the CA1 area of hippocampal slices. Exogenous application of recombinant sAβPPα increases NMDAR activation in aged animals and could rescue the age-related LTP deficits described. In contrast, it does not affect basal synaptic transmission or glutamate release. These results indicate that improving synaptic sAβPPα availability at synapses helps in reducing the functional NMDAR-related deregulation of hippocampal networks linked to aging.
authors.forename: Laura
authors.initials: L
authors.lastname: Moreno
authors.forename: Christiane
authors.initials: C
authors.lastname: Rose
authors.forename: Arun
authors.initials: A
authors.lastname: Mohanraj
authors.forename: Bernadette
authors.initials: B
authors.lastname: Allinquant
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Billard
authors.forename: Patrick
authors.initials: P
authors.lastname: Dutar
mesh_terms: D000375:Aging / Q000502:physiology*; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D004558:Electric Stimulation; D004591:Electrophoresis, Polyacrylamide Gel; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008839:Microelectrodes; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000378:metabolism; D046509:Tissue Culture Techniques
chemical_list: D016564:Amyloid beta-Protein Precursor; D016194:Receptors, N-Methyl-D-Aspartate; D011994:Recombinant Proteins; D053829:Amyloid Precursor Protein Secretases
keywords: Alzheimer’s disease; NMDA receptors; amyloid-β protein precursor; glutamate; memory; mouse hippocampus; synaptic plasticity; α-secretase