title: Chronic liver disease: Correlation of CEUS-based microperfusion and indocyanine green clearance.
abstract: OBJECTIVE
  To evaluate whether changes of dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation during chronic liver disease are correlated with the extent of impaired liver function, expressed by the indocyanine green (ICG) clearance.
  
  
  METHODS
  19 patients underwent CEUS examinations with previous or consecutive ICG clearance test. The ICG plasma disappearance rate (ICG-PDR) was determined using the noninvasive pulse-densitometric LiMON system. Quantification of peak enhancement (PE), rise time (RT) and the wash-in rate (WiR) was performed in the liver parenchyma (ROIliver) as well as in the portal vein (ROIportal vein) using a novel quantification software (VueBoxTM). To compare quantification parameters, patients were classified in patients representing a healthy population (ICG-PDR >16, n = 8) and those representing patients with liver disease (ICG-PDR ≤16, n = 11).
  
  
  RESULTS
  ROIportal vein showed significant differences comparing healthy patients and patients with liver disease for all perfusion parameters: PE and WiR were significantly higher in patients without liver disease (p = 0.048; p = 0.039). RT was significantly lower in healthy population (p = 0.039). Comparing perfusion parameters for ROIliver, PE was significantly higher in patients without liver disease (p = 0.039). There was no significant difference for RT (p = 0.804) and WiR (p = 0.058), respectively.
  
  
  CONCLUSIONS
  Within the framework of this study CEUS derived estimation of microcirculation did not prove to be a reliable estimator of liver function. RT, PE and WiR measured in the portal vein were significant perfusion factors in predicting liver function.
authors.affiliation: Institute for Radiology, University Hospital Regensburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Haimerl
authors.affiliation: Institute for Radiology, University Hospital Regensburg, Germany.
authors.forename: E-M
authors.initials: EM
authors.lastname: Jung
authors.affiliation: Institute for Radiology, University Hospital Regensburg, Germany.
authors.forename: L P
authors.initials: LP
authors.lastname: Beyer
authors.affiliation: Institute for Radiology, University Hospital Regensburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Pregler
authors.affiliation: Institute for Radiology, University Hospital Regensburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Dollinger
authors.affiliation: Department of Radiology, District Hospital of Orthopedics and Trauma Surgery, Piekary Śląskie, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Sieroń
authors.affiliation: Institute for Radiology, University Hospital Regensburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Niessen
authors.affiliation: Institute for Radiology, University Hospital Regensburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Stroszczynski
authors.affiliation: Institute for Radiology, University Hospital Regensburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Wiggermann
mesh_terms: D000368:Aged; D002908:Chronic Disease; D004396:Coloring Agents / Q000378:metabolism; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008107:Liver Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D010477:Perfusion; D014463:Ultrasonography
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green
keywords: CEUS; Chronic liver disease; ICG-test; liver function; microcirculation