title: Low cord blood serum levels of vitamin D: cause or effect of fetal macrosomia?
abstract: Aim: The aim of the study was to compare cord blood vitamin D levels of macrosomic large for gestational age (LGA) and appropriate gestational age (AGA) newborns.
  
  
  METHODS
  Seventy-nine healthy, normal term newborns were included in the study. They were divided by birth weight into two groups: 37 in the LGA group above 4,000 g, and 42 newborns in the AGA group birth weight between 3,000 g and 4,000 g. Cord blood samples from groups were collected. Circulating 25(OH)D was measured as 25 hydroxyvitamin D3 (25(OH)D3) by high-performance liquid chromatography (HPLC) in serum using a kit.
  
  
  RESULTS
  Maternal characterstics (age, body mass index [BMI], and gestational age) did not differ between the AGA and LGA groups. Cord blood 25 OH vitamin D levels were significantly low in neonates with LGA (p = 0,02).
  
  
  CONCLUSIONS
  The authors found that macrosomic infants had low levels of vitamin D. Providing vitamin D supplements to pregnant women may prevent macrosomia. Randomized controlled trials are needed to prove this assertion.
authors.forename: S
authors.initials: S
authors.lastname: Yilmaz
authors.forename: A
authors.initials: A
authors.lastname: Aktulay
authors.forename: C
authors.initials: C
authors.lastname: Demirtas
authors.forename: Y
authors.initials: Y
authors.lastname: Engin-Ustun
mesh_terms: D000328:Adult; D001724:Birth Weight; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D019587:Dietary Supplements; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005320:Fetal Macrosomia / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood*
chemical_list: D014807:Vitamin D