title: Nanoimprinted Patterned Pillar Substrates for Surface-Enhanced Raman Scattering Applications.
abstract: A pragmatic method to deposit silver nanoparticles on polydopamine-coated nanoimprinted pillars for use as surface-enhanced Raman scattering (SERS) substrates was developed. Pillar arrays consisting of poly(methyl methacrylate) (PMMA) that ranged in diameter from 300 to 500 nm were fabricated using nanoimprint lithography. The arrays had periodicities from 0.6 to 4.0 μm. A polydopamine layer was coated on the pillars in order to facilitate the reduction of silver ions to create silver nucleation sites during the electroless deposition of sliver nanoparticles. The size and density of silver nanoparticles were controlled by adjusting the growth time for the optimization of the SERS performance. The size of the surface-adhered nanoparticles ranged between 75 and 175 nm, and the average particle density was ∼30 particles per μm(2). These functionalized arrays had a high sensitivity and excellent signal reproducibility for the SERS-based detection of 4-methoxybenzoic acid. The substrates were also able to allow the SERS-based differentiation of three types of bacteriophages (λ, T3, and T7).
authors.affiliation: Department of Food Science, University of Massachusetts , 102 Holdsworth Way, Amherst, Massachusetts 01003, United States.
authors.forename: Juhong
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts , 120 Governors Drive, Amherst, Massachusetts 01003, United States.
authors.forename: Yinyong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Food Science, University of Massachusetts , 102 Holdsworth Way, Amherst, Massachusetts 01003, United States.
authors.forename: Kang
authors.initials: K
authors.lastname: Huang
authors.affiliation: Department of Food Science, University of Massachusetts , 102 Holdsworth Way, Amherst, Massachusetts 01003, United States.
authors.forename: Panxue
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Food Science, University of Massachusetts , 102 Holdsworth Way, Amherst, Massachusetts 01003, United States.
authors.forename: Lili
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts , 120 Governors Drive, Amherst, Massachusetts 01003, United States.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Carter
authors.affiliation: Department of Food Science, University of Massachusetts , 102 Holdsworth Way, Amherst, Massachusetts 01003, United States.
authors.forename: Sam R
authors.initials: SR
authors.lastname: Nugen
mesh_terms: D001435:Bacteriophages / Q000737:chemistry / Q000302:isolation & purification; D062425:Hydroxybenzoate Ethers / Q000032:analysis; D053768:Metal Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*; D013499:Surface Properties
chemical_list: D062425:Hydroxybenzoate Ethers; D012834:Silver; C004520:4-anisic acid
keywords: bacteriophage discrimination; nanoimprint lithography; pillar array; silver nanoparticle; surface-enhanced Raman scattering