title: How to outsmart NK cell tolerance.
abstract: Immune tolerance induced by regulatory mechanisms is an integral and fundamental part of immunity. In therapeutic settings, however, tolerance may significantly limit efficacy. Here, we summarize possible strategies to enhance therapeutic antibody dependent cellular cytotoxicity by overcoming NK cell tolerance.
authors.affiliation: Department of Biomedicine; University Hospital Basel ; Basel, Switzerland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Terszowski
authors.affiliation: Roche Pharma Research and Early Development; Roche Innovation Center Zurich ; Schlieren, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Klein
authors.affiliation: Department of Biomedicine; University Hospital Basel ; Basel, Switzerland.
authors.forename: Laurent
authors.initials: L
authors.lastname: Schmied
authors.affiliation: Department of Biomedicine; University Hospital Basel ; Basel, Switzerland ; Roche Pharma Research and Early Development; Roche Innovation Center Zurich ; Schlieren, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Stern
keywords: ADCC; CD20; HLA; KIR; NK cell tolerance; lirilumab; obinutuzumab; rituximab