title: [Enhancing of drug bioavailability using liquisolid system formulation].
abstract: One of the modern technologies of how to ensure sufficient bioavailability of drugs with limited water solubility is represented by the preparation of liquisolid systems. The functional principle of these formulations is the sorption of a drug in a liquid phase to a porous carrier (aluminometasilicates, microcrystalline cellulose, etc.). After addition of further excipients, in particular a coating material (colloidal silica), a powder is formed with the properties suitable for conversion to conventional solid unit dosage forms for oral administration (tablets, capsules). The drug is subsequently administered to the GIT already in a dissolved state, and moreover, the high surface area of the excipients and their surface hydrophilization by the solvent used, facilitates its contact with and release to the dissolution medium and GI fluids. This technology, due to its ease of preparation, represents an interesting alternative to the currently used methods of bioavailability improvement. The article follows up, by describing the specific aspects influencing the preparation of liquid systems, on the already published papers about the bioavailability of drugs and the possibilities of its technological improvement.Key words: liquisolid systems bioavailability porous carrier coating material preformulation studies.
authors.forename: Jan
authors.initials: J
authors.lastname: Gajdziok
authors.forename: Barbora
authors.initials: B
authors.lastname: Vraníková
mesh_terms: D001682:Biological Availability; D002214:Capsules; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D005079:Excipients / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D016062:Porosity; D011208:Powders; D012822:Silicon Dioxide / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013607:Tablets
chemical_list: D002214:Capsules; D005079:Excipients; D004364:Pharmaceutical Preparations; D011208:Powders; D012997:Solvents; D013607:Tablets; D012822:Silicon Dioxide