title: Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities.
abstract: Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1) and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 (g(mL(-1).
authors.affiliation: School of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Guo
authors.affiliation: Institute of Traditional Chinese Medicine, Heilongjiang Traditional Chinese Medicine Academy of Sciences, Harbin 110016, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Institute of Traditional Chinese Medicine, Heilongjiang Traditional Chinese Medicine Academy of Sciences, Harbin 110016, China.
authors.forename: Xue-Ying
authors.initials: XY
authors.lastname: Guo
authors.affiliation: School of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Cui
authors.affiliation: School of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.affiliation: Institute of Traditional Chinese Medicine, Heilongjiang Traditional Chinese Medicine Academy of Sciences, Harbin 110016, China.
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Huo
authors.affiliation: Institute of Traditional Chinese Medicine, Heilongjiang Traditional Chinese Medicine Academy of Sciences, Harbin 110016, China. Electronic address: zyyjy@163.com.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy*; D045744:Cell Line, Tumor; D006801:Humans; D031324:Juglans / Q000737:chemistry*; D009284:Naphthols / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D009754:Nuts / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: C000608797:4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one; C000608798:4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one; D000972:Antineoplastic Agents, Phytogenic; D009284:Naphthols; D010936:Plant Extracts
keywords: Anticancer activity; Juglans mandshurica; Juglanstetralone A; Juglanstetralone B; Walnut husk