title: Inflammatory bowel disease on the risk of acute pancreatitis: A population-based cohort study.
abstract: OBJECTIVE
  To determine whether inflammatory bowel disease (IBD) influences the risk of acute pancreatitis.
  
  
  METHODS
  We identified 11,909 patients diagnosed with IBD between 2000 and 2010 from Taiwan National Health Insurance Research Database as the study cohort. A comparison cohort comprised 47,636 age-matched patients without IBD. Both cohorts were followed-up until the end of 2010 or until being censored. Cox proportional hazards regression models were used to study the effects of IBD on the risks of acute pancreatitis.
  
  
  RESULTS
  The overall incidence of acute pancreatitis was 3.56-fold higher in the study cohort than in the comparison cohort (31.8 vs 8.91 per 10,000 person-years, crude hazard ratio [HR] = 3.56, 95% confidence interval [CI] = 2.96-4.28). After adjustment for age, sex, and comorbidities, namely alcohol-related disease, biliary stone, hypertension, hyperlipidemia, diabetes mellitus, obesity, hepatitis B, hepatitis C, hypertriglyceridemia, cardiovascular diseases, chronic kidney disease, chronic obstructive pulmonary disease, and hypercalcemia, the adjusted HR for acute pancreatitis was 2.93-fold higher (95% CI = 2.40-3.58) in the study cohort than in the comparison cohort.
  
  
  CONCLUSIONS
  IBD is a risk factor for acute pancreatitis.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Feng Yuan Hospital Ministry of Health and Welfare, Taichung, Taiwan.
authors.forename: Yu-Tso
authors.initials: YT
authors.lastname: Chen
authors.affiliation: Division of Gastroenterology and Hepatology, Kuang Tien General Hospital, Taichung, Taiwan.
authors.forename: Jiann-Sheng
authors.initials: JS
authors.lastname: Su
authors.affiliation: Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Tseng
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Chia-Chang
authors.initials: CC
authors.lastname: Chen
authors.affiliation: School of Medicine, China Medical University, Taichung, Taiwan.|Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.affiliation: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.|Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D019973:Alcohol-Related Disorders / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D019992:Databases as Topic; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D042882:Gallstones / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000453:epidemiology / Q000209:etiology*; D011159:Population Surveillance; D016016:Proportional Hazards Models; D012306:Risk
keywords: Crohn's disease; acute pancreatitis; inflammatory bowel disease; ulcerative colitis