title: A Self-Assembled Albumin-Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging.
abstract: A photoacoustic nanoprobe is self-assembled from human serum albumin and two types of dye molecules, one is inert to pH and the other is pH sensitive. This probe and the quantitative ratiometric photoacoustic pH imaging method are shown to have high safety, be easy-to-operate, and have depth-independent accuracy for real-time in vivo pH imaging of entire tumors. These features make them promising for future cancer prognosis and therapeutic planning.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Polymer Science and Engineering, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Jiawen
authors.initials: J
authors.lastname: Chen
authors.affiliation: School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Department of Polymer Science and Engineering, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Zhenping
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D001565:Benzoates / Q000737:chemistry; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry*; D061848:Optical Imaging / Q000379:methods*; D010078:Oxazines / Q000737:chemistry; D061088:Photoacoustic Techniques / Q000379:methods*; D011487:Protein Conformation; D012709:Serum Albumin / Q000737:chemistry*
chemical_list: D001565:Benzoates; D005456:Fluorescent Dyes; C000601126:IR825 dye; D007211:Indoles; D010078:Oxazines; D012709:Serum Albumin; C039203:phenoxazine
keywords: albumin; in vivo pH detection; nanoprobes; photoacoustic imaging; self-assembly