title: Dengue vaccines: what we know, what has been done, but what does the future hold?
abstract: Dengue, a disease caused by any of the four serotypes of dengue viruses, is the most important arthropod-borne viral disease in the world in terms of both morbidity and mortality. The infection by these viruses induces a plethora of clinical manifestations ranging from asymptomatic infections to severe diseases with involvement of several organs. Severe forms of the disease are more frequent in secondary infections by distinct serotypes and, consequently, a dengue vaccine must be tetravalent. Although several approaches have been used on the vaccine development, no vaccine is available against these viruses, especially because of problems on the development of a tetravalent vaccine. Here, we describe briefly the vaccine candidates available and their ability to elicit a protective immune response. We also discuss the problems and possibilities of any of the vaccines in final development stage reaching the market for human use.
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, BR.
authors.forename: Emiliana Pereira
authors.initials: EP
authors.lastname: Abrão
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, BR.
authors.forename: Danillo Lucas Alves
authors.initials: DL
authors.lastname: Espósito
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, BR.
authors.forename: Flávio
authors.initials: F
authors.lastname: Lauretti
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, BR.
authors.forename: Benedito Antonio Lopes
authors.initials: BA
authors.lastname: da Fonseca
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology; D001938:Brazil; D002986:Clinical Trials as Topic; D003715:Dengue / Q000517:prevention & control*; D053059:Dengue Vaccines; D003716:Dengue Virus / Q000276:immunology; D017277:Drug Approval; D006801:Humans
chemical_list: D000914:Antibodies, Viral; D053059:Dengue Vaccines