title: Immunogenic properties and mycoplasmal pneumonia of swine (MPS) lung lesions in Large White pigs selected for higher peripheral blood immune capacity.
abstract: Immunogenic properties and mycoplasmal pneumonia of swine (MPS) lung lesions were compared between the immunity-selected Large White line and the non-selected Large White line. The selected Large White line showed a higher level of pulmonary MPS lesions compared with the non-selected Large White line. Subsequent to vaccination, the percentage of natural killer cells and T cells (CD3(+) CD4(+) CD8(-) and CD3(+) CD4(-) CD8(+) T cells) were significantly increased in the non-selected line but remained unchanged in the immunity-selected Large White line. Secretion of Mycoplasma hyopneumoniae vaccine-specific immunoblogulin G and phagocyte activity in peripheral blood were significantly higher in the immunity-selected Large White line than in the non-selected line. Expression of interleukin (IL)-4 and IL-6 messenger RNA in hilar lymph nodes was significantly lower in the immunity-selected Large White line than in the non-selected line. However, expression of IL-10 in all immune tissues was significantly higher in the immunity-selected Large White line. These results suggest that the selection for high immunity was not effective in increasing resistance to MPS lung lesions.
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Liushiqi
authors.initials: L
authors.lastname: Borjigin
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shimazu
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Katayama
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Meihua
authors.initials: M
authors.lastname: Li
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Takumi
authors.initials: T
authors.lastname: Satoh
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Haruki
authors.initials: H
authors.lastname: Kitazawa
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Sang-Gun
authors.initials: SG
authors.lastname: Roh
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Aso
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Katoh
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Food, Agriculture and Environment, Miyagi University, Sendai.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Suda
authors.affiliation: Miyagi Prefecture Animal Industry Experiment Station, Osaki, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Sakuma
authors.affiliation: Miyagi Prefecture Animal Industry Experiment Station, Osaki, Japan.
authors.forename: Mituru
authors.initials: M
authors.lastname: Nakajo
authors.affiliation: Graduate School of Agricultural Science, Tohoku University.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology; D001769:Blood / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D016753:Interleukin-10; D015847:Interleukin-4; D015850:Interleukin-6; D007694:Killer Cells, Natural / Q000276:immunology; D008168:Lung / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D009177:Mycoplasma pneumoniae / Q000276:immunology; D010587:Phagocytosis; D011019:Pneumonia, Mycoplasma / Q000276:immunology* / Q000662:veterinary*; D013552:Swine / Q000276:immunology*; D013553:Swine Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D015850:Interleukin-6; D016753:Interleukin-10; D015847:Interleukin-4
keywords: disease resistance; immunogenic property; mycoplasmal pneumonia lesion; pig