title: TLR5 signaling, commensal microbiota and systemic tumor promoting inflammation: the three parcae of malignant progression.
abstract: We have reported that TLR5-mediated recognition of commensal microbiota modulates systemic tumor-promoting inflammation and malignant progression of tumors at distal locations. Approximately 7-10% of the general population harbors a deleterious single nucleotide polymorphism in TLR5, implicating a novel role for genetic variation during the initiation and progression of cancer.
authors.affiliation: Tumor Microenvironment and Metastasis Program; The Wistar Institute ; Philadelphia, PA USA.
authors.forename: Melanie R
authors.initials: MR
authors.lastname: Rutkowski
authors.affiliation: Tumor Microenvironment and Metastasis Program; The Wistar Institute ; Philadelphia, PA USA.
authors.forename: Jose R
authors.initials: JR
authors.lastname: Conejo-Garcia
keywords: cancer; inflammation; microbiota; toll-like receptor; tumor immunology; tumor macroenvironment; tumor microenvironment; tumor-induced immune suppression