title: Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields.
abstract: The paper describes the concept of magneto-mechanical actuation of single-domain magnetic nanoparticles (MNPs) in super-low and low frequency alternating magnetic fields (AMFs) and its possible use for remote control of nanomedicines and drug delivery systems. The applications of this approach for remote actuation of drug release as well as effects on biomacromolecules, biomembranes, subcellular structures and cells are discussed in comparison to conventional strategies employing magnetic hyperthermia in a radio frequency (RF) AMF. Several quantitative models describing interaction of functionalized MNPs with single macromolecules, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented. The optimal characteristics of the MNPs and an AMF for effective magneto-mechanical actuation of single molecule responses in biological and bio-inspired systems are discussed. Altogether, the described studies and phenomena offer opportunities for the development of novel therapeutics both alone and in combination with magnetic hyperthermia.
authors.affiliation: Nanocenter, G. R. Derzhavin Tambov State University, Tambov 392000, Russian Federation; Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, 117234, Russian Federation.
authors.forename: Yuri I
authors.initials: YI
authors.lastname: Golovin
authors.affiliation: Nanocenter, G. R. Derzhavin Tambov State University, Tambov 392000, Russian Federation.
authors.forename: Sergey L
authors.initials: SL
authors.lastname: Gribanovsky
authors.affiliation: Nanocenter, G. R. Derzhavin Tambov State University, Tambov 392000, Russian Federation.
authors.forename: Dmitry Y
authors.initials: DY
authors.lastname: Golovin
authors.affiliation: Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, 117234, Russian Federation; Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA.
authors.forename: Natalia L
authors.initials: NL
authors.lastname: Klyachko
authors.affiliation: Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, 117234, Russian Federation; National University of Science and Technology MISiS, Leninskiy pr., 9, Moscow 119049, Russian Federation.
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Majouga
authors.affiliation: Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA.
authors.forename: Аlyssa M
authors.initials: АM
authors.lastname: Master
authors.affiliation: Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Sokolsky
authors.affiliation: Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, 117234, Russian Federation; Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: kabanov@email.unc.edu.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kabanov
mesh_terms: D016503:Drug Delivery Systems; D006979:Hyperthermia, Induced; D060526:Magnetic Fields; D050997:Nanomedicine; D053758:Nanoparticles / Q000008:administration & dosage*
keywords: Alternating magnetic field; Magnetic nanoparticles; Magneto-mechanical actuation; Nanomedicine