title: Priming the Surface of Orthopedic Implants for Osteoblast Attachment in Bone Tissue Engineering.
abstract: The development of better orthopedic implants is incessant. While current implants can function reliably in the human body for a long period of time, there are still a significant number of cases for which the implants can fail prematurely due to poor osseointegration of the implant with native bone. Increasingly, it is recognized that it is extremely important to facilitate the attachment of osteoblasts on the implant so that a proper foundation of extracellular matrix (ECM) can be laid down for the growth of new bone tissue. In order to facilitate the osseointegration of the implant, both the physical nanotopography and chemical functionalization of the implant surface have to be optimized. In this short review, however, we explore how simple chemistry procedures can be used to functionalize the surfaces of three major classes of orthopedic implants, i.e. ceramics, metals, and polymers, so that the attachment of osteoblasts on implants can be facilitated in order to promote implant osseointegration.
authors.affiliation: 2. Institute of Bioengineering and Nanotechnology, Nanos, Singapore 138669, Singapore.
authors.forename: Kiat Hwa
authors.initials: KH
authors.lastname: Chan
authors.affiliation: 1. Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou 350007, China.
authors.forename: Shuangmu
authors.initials: S
authors.lastname: Zhuo
authors.affiliation: 3. Institute of Bioengineering and Nanotechnology, Nanos, Singapore 138669, Singapore.
authors.forename: Ming
authors.initials: M
authors.lastname: Ni
mesh_terms: D001842:Bone and Bones / Q000502:physiology; D002448:Cell Adhesion; D002516:Ceramics / Q000737:chemistry; D006801:Humans; D008670:Metals / Q000737:chemistry; D009989:Orthotic Devices; D010006:Osteoblasts / Q000166:cytology*; D011108:Polymers / Q000737:chemistry; D019736:Prostheses and Implants; D013234:Stem Cells / Q000166:cytology; D017154:Stromal Cells / Q000166:cytology; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D008670:Metals; D011108:Polymers
keywords: orthopedic implant; osseointegration