title: RIOK3 keeps MDA5 inactive.
authors.affiliation: Department of Microbiology and Immunology, Graduate School of Medecine, Hokkaido University, Sapporo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Takashima
authors.affiliation: Department of Microbiology and Immunology, Graduate School of Medecine, Hokkaido University, Sapporo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oshiumi
authors.affiliation: Department of Microbiology and Immunology, Graduate School of Medecine, Hokkaido University, Sapporo, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Seya
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000276:immunology / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D007113:Immunity, Innate; D000072640:Interferon-Induced Helicase, IFIH1; D017346:Protein Serine-Threonine Kinases / Q000276:immunology / Q000378:metabolism*; D012330:RNA, Double-Stranded / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012367:RNA, Viral / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D012330:RNA, Double-Stranded; D012334:RNA, Neoplasm; D012367:RNA, Viral; D017346:Protein Serine-Threonine Kinases; C534426:RIO kinase 3, human; C452815:IFIH1 protein, human; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1
keywords: MDA5 phosphorylation; RIO kinase; RNA sensing; autoimmune disorder; type I interferon