title: Pathophysiology of Osteonecrosis of the Jaws.
abstract: Osteonecrosis of the jaw (ONJ) is a multifactorial disease in patients with primary or metastatic bone malignancy or osteoporosis undergoing systemic antiresorptive therapy, where pathophysiology has not yet been fully determined. The staging of ONJ is based on severity of symptoms and extent of clinical and radiographic findings. Treatment strategies range from conservative local wound care to aggressive resective surgery of all necrotic bone. The first ONJ cases were reported in 2003 and 2004, and although significant progress has been made in our understanding of the disease, much more work needs to be done to completely explain its pathophysiology.
authors.affiliation: Section of Oral and Maxillofacial Surgery, Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, 10833 Le Conte Ave., Los Angeles, CA 90095-1668, USA. Electronic address: taghaloo@dentistry.ucla.edu.
authors.forename: Tara
authors.initials: T
authors.lastname: Aghaloo
authors.affiliation: Section of Special Patient Care, Division of Advanced Prosthodontics and Section of Restorative Dentistry, Division of Regenerative and Constitutive Sciences, UCLA School of Dentistry, 10833 Le Conte Ave., Los Angeles, CA 90095-1668, USA.
authors.forename: Renna
authors.initials: R
authors.lastname: Hazboun
authors.affiliation: Section of Oral and Maxillofacial Radiology, Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, 10833 Le Conte Ave., Los Angeles, CA 90095-1668, USA; Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Tetradis
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000503:physiopathology* / Q000628:therapy; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: Antiresorptive; Bisphosphonates; MRONJ; Osteonecrosis of the jaws (ONJ); Pathophysiology