title: SPECIFIC SERUM IMMUNOGLOBULIN G AGAINST CHLAMYDIA PNEUMONIAE IN HEALTHY CHILDREN AND ADULTS IN SOUTH-EAST OF IRAN.
abstract: BACKGROUND
  Chlamydia pneumoniae (C. pneumonia) is an obligate intracellular bacterium and recognized as a risk factor for several diseases such as asthma, atherosclerosis and arthritis. The aim of this study was to determine the seroprevalence of C. pneumonia in healthy subjects in different age groups.
  
  
  METHODS
  The serum levels of anti C. pneumonia IgG were measured by using of ELISA.
  
  
  RESULTS
  Totally, 630 subjects (164 children and 466 adults) were included into study. The seroprevalence and the mean titer of anti C. pneumonia antibody were 11.3% and 14.48?2.18 RU/mL; at age 510 years, 15% and 17.47 +/- 2.40 RU/mL at age 11-20 years, 21% and 25.15 +/- 4.56 RU/mL at age 21-30 years group, 40% and 53.77 +/- 6.40 RU/mL at age 31-40 years, 94% and 146.41 +/- 8.95 RU/mL at age 41-50 years, 98% and 153.59 +/- 10.38 RU/mL at age 51-60 years, 96% and 138.80 +/- 12.78 RU/mL at age 61-70 years, respectively. The differences of the seroprevalence and the mean titer of anti C. pneumonia antibody between age groups were significant (p<0.0001). The sero-prevalence and the mean titer of anti C. pneumonia antibody were 11.6% and 14.33 +/- 1.49 RU/mL in children and 65.5% and 97.40 +/- 4.46 RU/mL in adults. The seroprevalence and the mean titer of anti C. pneumonia antibody were significantly higher in adults in comparison with those in children (p<0.0001).
  
  
  CONCLUSIONS
  These findings showed that the sero- prevalence and titer of anti C. pneumonia IgG were increased with advanced ages and were higher in adults as compared to children.
authors.forename: Maryam
authors.initials: M
authors.lastname: Nemati
authors.forename: Vahid
authors.initials: V
authors.lastname: Mirzaee
authors.forename: Ziba
authors.initials: Z
authors.lastname: Shaabani
authors.forename: Moein
authors.initials: M
authors.lastname: Zarrin
authors.forename: Sayed Ali
authors.initials: SA
authors.lastname: Mirabdolahi
authors.forename: Masoomeh
authors.initials: M
authors.lastname: Bagheri-Jamebozorgi
authors.forename: Mohammad-Taghi
authors.initials: MT
authors.lastname: Rezayati
authors.forename: Abdollah
authors.initials: A
authors.lastname: Jafarzadeh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D023521:Chlamydophila Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D015995:Prevalence; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; C048844:anti-IgG