title: Studies on batch formulation of a kit for the preparation of the 99mTc-Ubiquicidin (29-41): An infection imaging agent.
abstract: The aim of this study was to formulate an indigenous cold kit of Ubiquicidin, UBI (29-41), for easy preparation of (99m)Tc-UBI (29-41) to be used as an infection imaging agent. A two component kit with the peptide and SnCl2 as vial 1 and optimum amount of NaOH as vial 2 was successfully formulated as seen from the consistent radiochemical and pharmaceutical purity of the product over six consecutive batches of kits. The utility of the kit could be demonstrated through in-vitro and in vivo specificity of (99m)Tc-UBI (29-41).
authors.affiliation: Quality Control - Radiopharmaceuticals, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai 400703, India.
authors.forename: Chanda
authors.initials: C
authors.lastname: Arjun
authors.affiliation: Isotope Production & Applications Division, Bhabha Atomic Research Centre (BARC), Mumbai 400085, India. Electronic address: archanamkhrj@gmail.com.
authors.forename: Archana
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: Isotope Production & Applications Division, Bhabha Atomic Research Centre (BARC), Mumbai 400085, India.
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Bhatt
authors.affiliation: Division of Animal Oncology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Navi Mumbai 410210, India.
authors.forename: Pradip
authors.initials: P
authors.lastname: Chaudhari
authors.affiliation: Quality Control - Radiopharmaceuticals, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai 400703, India.
authors.forename: Krishna Mohan
authors.initials: KM
authors.lastname: Repaka
authors.affiliation: Division of Physical and Chemical Sciences, International Atomic Energy Agency, 1400 Vienna, Austria.
authors.forename: Meera
authors.initials: M
authors.lastname: Venkatesh
authors.affiliation: Quality Control - Radiopharmaceuticals, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai 400703, India; Isotope Production & Applications Division, Bhabha Atomic Research Centre (BARC), Mumbai 400085, India.
authors.forename: Grace
authors.initials: G
authors.lastname: Samuel
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005612:Freeze Drying; D006801:Humans; D007239:Infections / Q000000981:diagnostic imaging*; D051379:Mice; D015609:Organotechnetium Compounds / Q000302:isolation & purification* / Q000493:pharmacokinetics; D010446:Peptide Fragments / Q000302:isolation & purification* / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000302:isolation & purification* / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds; D010446:Peptide Fragments; D019275:Radiopharmaceuticals; C485080:technetium 99m ubiquicidin(29-41)
keywords: (99m)Tc-UBI (29-41); Infection imaging; Kit formulation; Ubiquicidin (29–41)