title: Advantage of soybean isoflavone as antiandrogen on acne vulgaris.
abstract: BACKGROUND
  Acne vulgaris (AV) is the commonest skin disorder, whereas soybean isoflavone had been proved as antiandrogen that is it can inhibit the enzyme 3ß-hydroxysteroid dehydrogenase,17ß-hydroxysteroid dehydrogenase and 5α-reductase. The purpose of this study is to prove the advantage of soybean isoflavone as antiandrogen on AV.
  
  
  METHODS
  this study is a clinical study using randomized pretest-posttest control group design. This study is a study with 40 samples randomized into 2 groups, i.e. placebo group and 160 mgs of isoflavone group, the duration is 12 weeks, conducted a double-blind manner. The dependent variabel is total of AV lesion, whereas the intermediate variable is DHT that will be examined using ELISA. Defferential test and multivariate analysis were performed on dependent, independent and intermediate variables.
  
  
  RESULTS
  This study found that the difference in mean of total AV lesion before treatment was not significant (p: 0.099), whereas after treatment it differed significantly (p: 0.000), with significant delta difference (p: 0.000). Difference of mean DHT level before treatment was not significant (p: 0.574), whereas after treatment it differed significantly (p: 0.000), with significant delta difference (p: 0.000). Delta of DHT (p: 0.003) (r: 0.736) had significant influence on delta of total AV lesion (P < 0.05).
  
  
  CONCLUSIONS
  This study concludes that supplementation with 160 mgs/day of soybean isoflavone can reduce total AV lesion as a result of decreased DHT level.
authors.affiliation: Department of Dermatology and Venereology; Faculty of Medicine Diponegoro University; Hospital Kariadi ; Semarang, Indonesia.
authors.forename: Puguh
authors.initials: P
authors.lastname: Riyanto
authors.affiliation: Department of Dermatology and Venereology; Faculty of Medicine Diponegoro University; Hospital Kariadi ; Semarang, Indonesia.
authors.forename: Prasetyowati
authors.initials: P
authors.lastname: Subchan
authors.affiliation: Department of Nurition; Faculty of Medicine Diponegoro University; Hospital Kariadi ; Semarang, Indonesia.
authors.forename: Rosa
authors.initials: R
authors.lastname: Lelyana
keywords: DHT; acne vulgaris; soybean isoflavone