title: Excessive dietary phosphorus intake impairs endothelial function in young healthy men: a time- and dose-dependent study.
abstract: Excessive dietary phosphorus (P) has been speculated to be a risk factor for cardiovascular disease (CVD). Here, we performed a double-blinded crossover study to investigate the time- and dose-dependent effects of dietary P intake on endothelial function in healthy subjects. Sixteen healthy male volunteers were given meals containing 400, 800, and 1,200 mg P (P400, P800, and P1200 meals, respectively) with at least 7 days between doses. There were no differences in nutritional composition among the experimental diets except for P content. Blood biochemistry data and flow-mediated dilation (%FMD) of the brachial artery were measured while fasted, at 0 h, 1 h, 2 h, and 4 h after meal ingestion, and the next morning while fasted. The P800 and P1200 meals significantly increased serum P levels at 1-4 h after ingestion. A significant decrease in %FMD was observed between 1-4 h,while the P400 meal did not affect %FMD. We observed no differences among meals in serum P levels or %FMD the next morning. A significant negative correlation was observed between %FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people.
authors.affiliation: Department of Clinical Nutrition and Food Management, University of Tokushima Graduate School.
authors.forename: Tamae
authors.initials: T
authors.lastname: Nishi
authors.forename: Emi
authors.initials: E
authors.lastname: Shuto
authors.forename: Mariko
authors.initials: M
authors.lastname: Ogawa
authors.forename: Miho
authors.initials: M
authors.lastname: Ohya
authors.forename: Misaki
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Masashi
authors.initials: M
authors.lastname: Masuda
authors.forename: Misaki
authors.initials: M
authors.lastname: Katsumoto
authors.forename: Hisami
authors.initials: H
authors.lastname: Yamanaka-Okumura
authors.forename: Tohru
authors.initials: T
authors.lastname: Sakai
authors.forename: Eiji
authors.initials: E
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakaue
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Taketani
mesh_terms: D000328:Adult; D001916:Brachial Artery / Q000502:physiology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D008297:Male; D010758:Phosphorus / Q000097:blood; D016226:Phosphorus, Dietary / Q000008:administration & dosage*; D013997:Time Factors; D014664:Vasodilation
chemical_list: D016226:Phosphorus, Dietary; D010758:Phosphorus