title: Gastrointestinal Stromal Tumors in Northeastern Iran: 46 Cases During 2003-2012.
abstract: BACKGROUND Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. They are usually C-kit positive and seen slightly more common in men. These tumors are seen in the GI tract from the esophagus to the anus with occasional invasion or metastasis. METHODS In this retrospective study, we evaluated the prevalence of c-kit positive stromal tumors of the GI tract based on age, site of involvement, size of tumor, local invasion, and Immunohistochemical markers. The study was conducted in Mashhad University of Medical Sciences in Iran during 2003-2012. RESULTS Of the total 46 patients, 18 (39.1%) were men and 28(60.9%) were women with a mean age of 58.07 years (range: 18-93). Common sites of tumor were stomach, small intestine, esophagus and rectum, respectively. The number of mitoses per 50 HPF varied between zero and 160 mitoses. Overall, 23 cases had 5 mitoses 50/HPF (50%) and 23 tumors expressed <5 mitoses/50 HPF (50%). Local invasion and metastasis were observed in seven cases with extension to liver, pancreas, pregastric tissue, omentum, mesentery and appendix. Positive reaction for CD34, S100, actin and desmin was seen in 47.8%, 13%, 21.7%, and 4.3% of the patients, respectively. CONCLUSION Most patients were women. The prevalence of tumors in the esophagus was higher than the rectum. Invasion and metastasis did not correlate with mitotic rate, site and size of tumor. We suggest evaluation of genetic, racial and geographical or other unknown risk factors.
authors.affiliation: Assistant Professor , Internal Medicine Department, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Salari
authors.affiliation: Assistant Professor, Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mitra
authors.initials: M
authors.lastname: Ahadi
authors.affiliation: Assistant Professor, Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Mousalreza
authors.initials: SM
authors.lastname: Hoseini
authors.affiliation: Assistant Professor, Department of Gastroenterology and Hepatology, Nayshabour Faculty of Medical Sciences, Nayshabour, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Mokhtari
authors.affiliation: Anatomoclinical Department, Razavi Hospital, Mashhad, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Gafarzadehgan
authors.affiliation: Anatomoclinical Department, Razavi Hospital, Mashhad, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Hashemian
authors.affiliation: Researcher, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Benyamin
authors.initials: B
authors.lastname: Esmaeili
authors.affiliation: Associate Professor, Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Vossoughinia
keywords: GIST; Gastrointestinal stromal tumors; Iran