title: Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome.
abstract: This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP 'C' allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.
authors.affiliation: Department of Genetics, University College of Science, Osmania University, Hyderabad-500007, Andhra Pradesh, India.
authors.forename: Sameera Fatima
authors.initials: SF
authors.lastname: Qureshi
authors.affiliation: Department of Genetics, University College of Science, Osmania University, Hyderabad-500007, Andhra Pradesh, India.
authors.forename: Altaf
authors.initials: A
authors.lastname: Ali
authors.affiliation: Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Andhra Pradesh, India.
authors.forename: Ananthapur
authors.initials: A
authors.lastname: Venkateshwari
authors.affiliation: Institute of Genetics and Krishna Institute of Medical Sciences, Andhra Pradesh, India.
authors.forename: Hygriv
authors.initials: H
authors.lastname: Rao
authors.affiliation: Institute of Maternal and Child Health, Calicut Medical College, Calicut 8, Kerala, India.
authors.forename: M P
authors.initials: MP
authors.lastname: Jayakrishnan
authors.affiliation: Care Hospital, Hyderabad, Andhra Pradesh, India.
authors.forename: Calambur
authors.initials: C
authors.lastname: Narasimhan
authors.affiliation: Sri Jayadeva Institute of Cardiovascular Science and Research, Karnataka, India.
authors.forename: Jayaprakash
authors.initials: J
authors.lastname: Shenthar
authors.affiliation: Centre for Cellular and Molecular Biology, Andhra Pradesh, India.
authors.forename: Kumarasamy
authors.initials: K
authors.lastname: Thangaraj
authors.affiliation: Department of Genetics, University College of Science, Osmania University, Hyderabad-500007, Andhra Pradesh, India.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Nallari
keywords: atrial natriuretic peptide; biomarker; cardiogenesis; long QT syndrome; polymorphisms