title: Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United States.
abstract: OBJECTIVE
  To report the clinical outcomes of uveitis patients at the University of Virginia.
  
  
  METHODS
  Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. Parametric and nonparametric methods were used to analyze the change in best-corrected visual acuity (BCVA) in relation to demographics, diagnoses, management, and complications.
  
  
  RESULTS
  The study included 644 eyes of 491 patients. Patients with mild visual loss (logMAR <0.4) at presentation were younger than those with severe visual loss (SVL, logMAR >1.0) (P=0.002). Females were more likely to have mild visual loss as compared to males (P=0.025). Median overall BCVA was logMAR 0.18 at initial and final presentation (P=1.00). Vision loss at diagnosis was a predictor for moderate visual loss (MVL, logMAR 0.4 to <1.0) to SVL at last follow-up (P<0.001). Eyes with ocular hypertension were positively associated with MVL and SVL as compared to normotensive eyes (1.89 times at baseline, 2.62 times at last follow-up). Median BCVA was 0.18 logMAR for the anterior uveitis (AU) and 0.48 logMAR for the non-AU patients (P<0.001). AU patients were less likely to have SVL than non-AU group (P<0.001). AU group received local corticosteroids more frequently and systemic corticosteroids less commonly than non-AU patients (P<0.001). AU patients with MVL to SVL were more likely to have ophthalmic surgery (cataract, glaucoma or pars plana vitrectomy [PPV]) than those without MVL or SVL (P<0.001). Non-AU patients with MVL to SVL were more likely to have PPV than those without MVL or SVL (P=0.001).
  
  
  CONCLUSIONS
  Mean overall BCVA remained stable. Favorable visual results were associated with younger age, female gender, and AU. Poor visual prognosis was concomitant with SVL at presentation and ocular hypertension. Ocular surgery (cataract extraction and glaucoma filtration) was more frequently performed for AU patients with MVL to SVL than those AU patients who did not experience moderate to SVL. PPV was commonly performed for both AU and non-AU patients with MVL to SVL.
authors.affiliation: Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Asima
authors.initials: A
authors.lastname: Bajwa
authors.affiliation: Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Chang Sup
authors.initials: CS
authors.lastname: Lee
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
authors.forename: Jim
authors.initials: J
authors.lastname: Patrie
authors.affiliation: Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Xin
authors.affiliation: Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Ashvini K
authors.initials: AK
authors.lastname: Reddy
keywords: best corrected visual acuity; clinical outcome; uveitis; visual loss; visual outcome