title: Genetics and genomics of psychiatric disease.
abstract: Large-scale genomic investigations have just begun to illuminate the molecular genetic contributions to major psychiatric illnesses, ranging from small-effect-size common variants to larger-effect-size rare mutations. The findings provide causal anchors from which to understand their neurobiological basis. Although these studies represent enormous success, they highlight major challenges reflected in the heterogeneity and polygenicity of all of these conditions and the difficulty of connecting multiple levels of molecular, cellular, and circuit functions to complex human behavior. Nevertheless, these advances place us on the threshold of a new frontier in the pathophysiological understanding, diagnosis, and treatment of psychiatric disease.
authors.affiliation: Departments of Neurology, Psychiatry, and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. dhg@mednet.ucla jf@well.ox.ac.uk.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Geschwind
authors.affiliation: Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. dhg@mednet.ucla jf@well.ox.ac.uk.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Flint
mesh_terms: D004252:DNA Mutational Analysis; D018740:Genetic Heterogeneity; D023281:Genomics; D006801:Humans; D001523:Mental Disorders / Q000145:classification / Q000175:diagnosis* / Q000235:genetics*; D008957:Models, Genetic; D009154:Mutation; D012307:Risk Factors