title: Finding translation in stress research.
abstract: In our ongoing efforts to advance understanding of human diseases, translational research across rodents and humans on stress-related mental disorders stands out as a field that is producing discoveries that illuminate mechanisms of risk and pathophysiology at a brisk rate. Here we offer a Perspective on how a productive translational research dialog between preclinical models and clinical studies of these disorders is being powered by an ever-developing appreciation of the shared neural circuits and genetic architecture that moderate the response to stress across species. Working from these deep foundations, we discuss the approaches, both traditional and innovative, that have the potential to deliver a new generation of risk biomarkers and therapeutic strategies for stress-related disorders.
authors.affiliation: Laboratory of NeuroGenetics, Department of Psychology &Neuroscience, Duke University, Durham, North Carolina, USA.
authors.forename: Ahmad R
authors.initials: AR
authors.lastname: Hariri
authors.affiliation: Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Holmes
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D001523:Mental Disorders / Q000209:etiology; D013315:Stress, Psychological / Q000503:physiopathology / Q000523:psychology*; D057170:Translational Research, Biomedical