title: Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China.
abstract: BACKGROUND
  Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been reported to be strongly associated with type 2 diabetes mellitus (T2DM) in Icelandic, Danish and American populations and further replicated in other European populations, African Americans, Mexican Americans, and Asian populations. The aim of the present study was to investigate the association of TCF7L2 gene polymorphisms with T2DM in a Uygur population of China.
  
  
  METHODS
  877 T2DM patients and 871 controls were selected for the present study. Two single nucleotide polymorphisms (SNPs) (rs12255372 and rs7901695) were genotyped by using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. The associations of SNPs and haplotypes with T2DM and linkage disequilibrium (LD) structure of the TCF7L2 gene were analyzed.
  
  
  RESULTS
  For total participants and male, the distribution of rs12255372 alleles and the dominant model (Guanine Guanine (GG) genotype vs. Guanine Thymine (GT) genotype + Thymine Thymine (TT) genotype) showed significant difference between T2DM and control subjects (for allele: p = 0.013 and p = 0.002, respectively; for dominant model: p = 0.028 and p = 0.008, respectively). The distribution of rs7901695 alleles and the dominant model (TT genotype vs. Thymine Cytosine (TC) genotype + Cytosine Cytosine (CC) genotype) for total participants and male showed significant difference between T2DM and control subjects (for allele: both p = 0.001; for dominant model: p = 0.006 and p = 0.008, respectively).
  
  
  CONCLUSIONS
  Our data suggested that the genetic polymorphisms of the TCF7L2 gene were associated with T2DM in the Uygur population of China.
authors.affiliation: Xinjiang Key Laboratory of Metabolic Disease Research, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. yaohua01@sina.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Yao
authors.affiliation: Department of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830011, China. zhiqiangwang1987@sina.com.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830011, China. wangtingting2013@sina.com.
authors.forename: Tingting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830011, China. mayan16@sina.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830011, China. yinxia_su@163.com.
authors.forename: Yinxia
authors.initials: Y
authors.lastname: Su
authors.affiliation: Xinjiang Key Laboratory of Metabolic Disease Research, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. maqi1212@126.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Xinjiang Key Laboratory of Metabolic Disease Research, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. wl78154189@sina.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Xinjiang Key Laboratory of Metabolic Disease Research, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. zhujun6677@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000328:Adult; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000235:genetics; D005260:Female; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics* / Q000378:metabolism
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein
keywords: Case–control study; Single nucleotide polymorphism; TCF7L2; Type 2 diabetes mellitus