title: Cobalt(III)-Catalyzed Dehydrative [4+2] Annulation of Oxime with Alkyne by C-H and N-OH Activation.
abstract: Efficient, scalable cobalt-catalyzed redox-neutral [4+2] annulation of readily available oximes and alkyne is reported. The developed synthetic methodology is widely applicable and tolerates various functional groups including heterocycles. A stable Cp*Co(III) neutral complex is employed as the catalyst for this redox-neutral [4+2] annulation reaction, which progresses smoothly by way of a reversible cyclometallation without any external oxidizing agent, and produces only water as the side product.
authors.affiliation: Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur (India).
authors.forename: Malay
authors.initials: M
authors.lastname: Sen
authors.affiliation: Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur (India).
authors.forename: Deepti
authors.initials: D
authors.lastname: Kalsi
authors.affiliation: Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur (India). basker@iitk.ac.in.
authors.forename: Basker
authors.initials: B
authors.lastname: Sundararaju
keywords: CH activation; annulation; cobalt; heterocycles; isoquinoline