title: Effect of Increased Radiotoxicity on Survival of Patients with Non-small Cell Lung Cancer Treated with Curatively Intended Radiotherapy.
abstract: OBJECTIVE
  To elucidate the impact of different forms of radiation toxicities (esophagitis, radiation pneumonitis, mucositis and hoarseness), on the survival of patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Data were individually collected retrospectively for all patients diagnosed with NSCLC subjected to curatively intended radiotherapy (≥50 Gy) in Sweden during the time period 1990 to 2000.
  
  
  RESULTS
  Esophagitis was the only radiation-induced toxicity with an impact on survival (hazard ratio=0.83, p=0.016). However, in a multivariate model, with clinical- and treatment-related factors taken into consideration, the impact of esophagitis on survival was no longer statistically significant (hazard ratio=0.88, p=0.17).
  
  
  CONCLUSIONS
  The effect on survival seen in univariate analysis may be related to higher radiation dose and to the higher prevalence of chemotherapy in this group. The results do not suggest that the toxicities examined have any detrimental effect on overall survival.
authors.affiliation: Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden Department of Oncology, Gävle Hospital, Gävle, Sweden Holgersson@regiongavleborg.se.
authors.forename: Georg
authors.initials: G
authors.lastname: Holgersson
authors.affiliation: Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden Department of Oncology, Gävle Hospital, Gävle, Sweden.
authors.forename: Stefan
authors.initials: S
authors.lastname: Bergström
authors.affiliation: Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Liv
authors.affiliation: Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden Department of Oncology, Gävle Hospital, Gävle, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Nilsson
authors.affiliation: Department of Oncology, Gävle Hospital, Gävle, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Edlund
authors.affiliation: Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden Department of Oncology, Gävle Hospital, Gävle, Sweden.
authors.forename: Carl
authors.initials: C
authors.lastname: Blomberg
authors.affiliation: Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Nyman
authors.affiliation: Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Signe
authors.initials: S
authors.lastname: Friesland
authors.affiliation: Department of Oncology, Uppsala University Hospital, Uppsala, Sweden.
authors.forename: Simon
authors.initials: S
authors.lastname: Ekman
authors.affiliation: Department of Radiation Sciences and Oncology, Umeå University Hospital, Umeå, Sweden.
authors.forename: Thomas
authors.initials: T
authors.lastname: Asklund
authors.affiliation: Department of Radiation Sciences and Oncology, Umeå University Hospital, Umeå, Sweden.
authors.forename: Roger
authors.initials: R
authors.lastname: Henriksson
authors.affiliation: Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden Department of Oncology, Gävle Hospital, Gävle, Sweden Department of Radiation Sciences and Oncology, Umeå University Hospital, Umeå, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Bergqvist
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy; D004941:Esophagitis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D017564:Radiation Pneumonitis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D015996:Survival Rate
keywords: NSCLC; esophagitis; radiotherapy; survival; toxicity