title: Evaluation of Biodistribution of Functionalized Magnetic Core/Carbon-Shell Nanoparticles in Systemic Method of Administration.
abstract: We studied new magnetic nanocomposites consisting of a core(Fe) and carbon-shell inert to biological media. Iron-carbon nanoparticles circulate in the bloodstream for several minutes and are primarily accumulated in the liver; less intensive accumulation was found in the spleen and minimum in the lungs, kidneys, and heart. Accumulation of nanoparticles in the liver leads to the development of destructive processes and is accompanied by activation of compensatory-adaptive mechanisms. In the liver and spleen, structural changes are mild and mainly relate to changes in the microvasculature. In 6 months, the total content of nanoparticles in all tissues decreased due to their elimination from the body and the structure of the organs returned to normal.
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.|Ural Federal University n. a. First President of Russia B. N. Yeltsin, Ekaterinburg, Russia.
authors.forename: B G
authors.initials: BG
authors.lastname: Yushkov
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia. artashyan@inbox.ru.|Ural Federal University n. a. First President of Russia B. N. Yeltsin, Ekaterinburg, Russia. artashyan@inbox.ru.
authors.forename: O S
authors.initials: OS
authors.lastname: Artashyan
authors.affiliation: Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Medvedeva
authors.affiliation: Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Byzov
authors.affiliation: Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Uimin
authors.affiliation: Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Ermakov
authors.affiliation: Ural Federal University n. a. First President of Russia B. N. Yeltsin, Ekaterinburg, Russia.
authors.forename: M Yu
authors.initials: MY
authors.lastname: Bykova
authors.affiliation: Ural Federal University n. a. First President of Russia B. N. Yeltsin, Ekaterinburg, Russia.
authors.forename: I M
authors.initials: IM
authors.lastname: Petrova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics*; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008297:Male; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D058185:Magnetite Nanoparticles
keywords: biodistribution; iron-carbon nanoparticles