title: Screening for colorectal cancer in Italy: 2011-2012 survey.
abstract: We utilised the IMPATTO study's archives to describe the 2000-2008 colorectal cancer (CRC) incidence rate trends in Italy, once screening programmes based on the faecal immunochemical test were implemented in different areas. Data on CRCs diagnosed in Italy from 2000 to 2008 in subjects aged 40-79 years were collected by 23 cancer registries. Incidence rate trends were evaluated as a whole and by macro-area (North-Centre and South-Islands), presence of a screening programme, sex, ten-year age class, anatomic site, stage at diagnosis, and pattern of diagnosis (screen-detected, non-screen-detected). The annual percent change (APC) of incidence rate trends, with 95% confidence intervals (95%CI), were computed. The study included 46,857 CRCs diagnosed in subjects aged 40-79 years, of which 2,806 were screen-detected. The incidence rates in the North-Centre were higher than in the South and on the Islands. During the study period, screening programmes had been implemented only in the North-Centre and had a significant effect on incidence rates, with an initial sharp increase in incidence, followed by a decrease that started in the 3rd-4th years of screening. These incidence rate trends were exclusively due to modifications in the rates of stage I cases. After screening programmes started, incidence increased in all anatomic sites, particularly in the distal colon. The differential figures introduced by the implementation of screening programmes warrant a continuous surveillance of CRC incidence and mortality trends to monitor the impact of screening at a national level.
authors.affiliation: Registro tumori del Veneto, Padova. manuel.zorzi@regione.veneto.it.
authors.forename: Manuel
authors.initials: M
authors.lastname: Zorzi
authors.forename: Lucia
authors.initials: L
authors.lastname: Mangone
authors.forename: Romano
authors.initials: R
authors.lastname: Sassatelli
authors.forename: Susanna
authors.initials: S
authors.lastname: Baracco
authors.forename: Mario
authors.initials: M
authors.lastname: Budroni
authors.forename: Marine
authors.initials: M
authors.lastname: Castaing
authors.forename: Claudia
authors.initials: C
authors.lastname: Cirilli
authors.forename: Rosanna
authors.initials: R
authors.lastname: Cusimano
authors.forename: Mario
authors.initials: M
authors.lastname: Fusco
authors.forename: Adriano
authors.initials: A
authors.lastname: Giacomin
authors.forename: Paolo
authors.initials: P
authors.lastname: Giorgi Rossi
authors.forename: Carlo
authors.initials: C
authors.lastname: Naldoni
authors.forename: Fabio
authors.initials: F
authors.lastname: Pannozzo
authors.forename: Silvano
authors.initials: S
authors.lastname: Piffer
authors.forename: Antonella
authors.initials: A
authors.lastname: Puppo
authors.forename: Francesco
authors.initials: F
authors.lastname: Tisano
authors.forename: Marco
authors.initials: M
authors.lastname: Zappa
mesh_terms: D000328:Adult; D000368:Aged; D003113:Colonoscopy / Q000706:statistics & numerical data*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D055088:Early Detection of Cancer; D005260:Female; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009780:Occult Blood