title: Pyridoxine deficiency in adult patients with status epilepticus.
abstract: An 8-year-old girl treated at our facility for superrefractory status epilepticus was found to have a low pyridoxine level at 5 μg/L. After starting pyridoxine supplementation, improvement in the EEG for a 24-hour period was seen. We decided to look at the pyridoxine levels in adult patients admitted with status epilepticus. We reviewed the records on patients admitted to the neurological ICU for status epilepticus (SE). Eighty-one adult patients were identified with documented pyridoxine levels. For comparison purposes, we looked at pyridoxine levels in outpatients with epilepsy (n=132). Reported normal pyridoxine range is >10 ng/mL. All but six patients admitted for SE had low normal or undetectable pyridoxine levels. A selective pyridoxine deficiency was seen in 94% of patients with status epilepticus (compared to 39.4% in the outpatients) which leads us to believe that there is a relationship between status epilepticus and pyridoxine levels.
authors.affiliation: Department of Neurology, Ochsner Medical Center, New Orleans, LA, USA.
authors.forename: Hina N
authors.initials: HN
authors.lastname: Dave
authors.affiliation: Department of Neurology, Ochsner Medical Center, New Orleans, LA, USA. Electronic address: eramsay@ochsner.org.
authors.forename: Richard
authors.initials: R
authors.lastname: Eugene Ramsay
authors.affiliation: Department of Neurology, Ochsner Medical Center, New Orleans, LA, USA.
authors.forename: Fawad
authors.initials: F
authors.lastname: Khan
authors.affiliation: Department of Neurology, Ochsner Medical Center, New Orleans, LA, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Sabharwal
authors.affiliation: Department of Neurology, Ochsner Medical Center, New Orleans, LA, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Irland
mesh_terms: D000328:Adult; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D011736:Pyridoxine / Q000097:blood; D012640:Seizures / Q000503:physiopathology; D013226:Status Epilepticus / Q000150:complications* / Q000453:epidemiology; D026681:Vitamin B 6 Deficiency / Q000453:epidemiology / Q000209:etiology*; D014803:Vitamin B Complex / Q000097:blood; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D014803:Vitamin B Complex; D005680:gamma-Aminobutyric Acid; D011736:Pyridoxine
keywords: Adult; Epilepsy; Pyridoxine deficiency; Status epilepticus; Vitamin B6 deficiency