title: The roles of CD147 in the progression of gliomas.
abstract: Gliomas are characterized by their invasiveness, angiogenesis, glycolysis and poor prognosis. Determining how to inhibit angiogenesis and glycolysis and induce cell death in gliomas is essential to the development of an effective therapy. CD147, a highly glycosylated transmembrane glycoprotein with two Ig-like extracellular domains that belongs to the immunoglobulin superfamily, plays an important role in the regulation of tumor invasiveness, angiogenesis and glycolysis by inducing the secretion of matrix metalloproteinases and vascular endothelial growth factor and by interacting with monocarboxylate transporters. In this review, we first summarize the roles played by CD147 in gliomas and then propose that CD147 may be a complementary prognostic biomarker and a possible therapeutic target for glioma treatment.
authors.affiliation: a 1 Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 71032, P.R. China.|b 2 Department of Cell Biology, College of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Fei
authors.affiliation: c 3 Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, P.R. China.
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Li
authors.affiliation: c 3 Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, P.R. China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Fei
authors.affiliation: b 2 Department of Cell Biology, College of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, P.R. China.
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D018450:Disease Progression; D005910:Glioma / Q000473:pathology* / Q000628:therapy; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000473:pathology; D011379:Prognosis
chemical_list: C497886:BSG protein, human; D014408:Biomarkers, Tumor; D051926:Basigin
keywords: CD147; angiogenesis; glioma; glycolysis; invasiveness