title: Interstitial deletion at 11q14.2-11q22.1 may cause severe learning difficulties, mental retardation and mild heart defects in 13-year old male.
abstract: Interstitial deletions of the long arm of chromosome 11 are rare, and they could be assumed as non-recurrent chromosomal rearrangements due to high variability of the size and the breakpoints of the deleted region. The exact region of the deletion was difficult to be determined before the use of molecular cytogenetic techniques such as array comparative genomic hybridization (aCGH). Here, a 13-year old boy with severe learning difficulties, mental retardation and mild heart defects is described. Conventional G-band karyotyping was performed and it is found that the patient is a carrier of a de novo interstitial deletion on the long arm of chromosome 11, involving 11q14 and 11q22 breakpoints. Further investigation, using aCGH, specified the deleted region to 11q14.2-11q22.1. There was a difficulty in correlating the genotype with the phenotype of the patient due to lack of similar cases in literature. More studies should be done in order to understand the genetic background that underlies the phenotypic differences observed in similar cases.
authors.affiliation: Access to genome P.C., Clinical Laboratory Genetics, 33A Ethn. Antistaseos str, 55134 Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Papoulidis
authors.affiliation: Access to genome P.C., Clinical Laboratory Genetics, 33A Ethn. Antistaseos str, 55134 Thessaloniki, Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Paspaliaris
authors.affiliation: Access to genome P.C., Clinical Laboratory Genetics, 33A Ethn. Antistaseos str, 55134 Thessaloniki, Greece.
authors.forename: Elisavet
authors.initials: E
authors.lastname: Siomou
authors.affiliation: Department of Medical Genetics, University of Cagliari, Binaghi Hospital, Cagliari, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Orru
authors.affiliation: Department of Medical Genetics, University of Cagliari, Binaghi Hospital, Cagliari, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Murru
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Heraklion, Heraklion, Crete Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Sifakis
authors.affiliation: Embryoiatriki-genetiki Ltd, 49 Kifisias Ave., Athens, Greece.
authors.forename: Petros
authors.initials: P
authors.lastname: Nikolaidis
authors.affiliation: Department of Gynecology, Larissa Medical School, University of Thessaly, Larissa, Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Garas
authors.affiliation: Department of Gynecology, Larissa Medical School, University of Thessaly, Larissa, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Sotiriou
authors.affiliation: Developmental Assessment Unit, Second Department of Paediatrics, P&A Kyriakou Children's Hospital, University of Athens, 11527 Athens, Greece.
authors.forename: Loretta
authors.initials: L
authors.lastname: Thomaidis
authors.affiliation: Access to genome P.C., Clinical Laboratory Genetics, 33A Ethn. Antistaseos str, 55134 Thessaloniki, Greece ; Department of Medical Genetics, University of Cagliari, Binaghi Hospital, Cagliari, Italy.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Manolakos