title: [Research on biological detoxification of Chinese medicine containing aristolochic acid A by ten microorganisms].
abstract: This paper was aim to screen microorganisms with attenualed efficiency for Chinese medicine containing aristolochic acid A by liquid-state fermentation. Twelve Chinese medicine were detected by UPLC and aristolochic acid A was only founded in four species of Aristolochia, those were Caulis Aristolochiae Manshuriensis, Aristolochiae Radix, Aistolochia Contorta Bunge and Herba Aristolochiae Mollissima,but not in the others. With the four Chinese medicine containing aristolochic acid A as raw material, ten microorganisms were tested, and the content of aristolochic acid A was detected by UPLC. The results showed that one microorganism can decrease content of aristolochic acid A in all those four Chinese medicine.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
authors.forename: Zhou-jin
authors.initials: ZJ
authors.lastname: Tan
authors.forename: Bo-hou
authors.initials: BH
authors.lastname: Xia
authors.forename: Jia-chi
authors.initials: JC
authors.lastname: Xie
authors.forename: Lin-mei
authors.initials: LM
authors.lastname: Lin
authors.forename: Duan-fang
authors.initials: DF
authors.lastname: Liao
mesh_terms: D034341:Aristolochic Acids / Q000032:analysis / Q000378:metabolism*; D001419:Bacteria / Q000378:metabolism*; D001711:Biotransformation; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry / Q000382:microbiology*
chemical_list: D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; C000228:aristolochic acid I