title: Proteins of Bartonella bacilliformis: Candidates for Vaccine Development.
abstract: Bartonella bacilliformis is the etiologic agent of Carrión's disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrión's disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and the human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine.
authors.affiliation: Hospital Universitario Fundacion Alcorcon, Calle Budapest 1, 28922 Madrid, Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Henriquez-Camacho
authors.affiliation: Instituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima 31, Peru.
authors.forename: Palmira
authors.initials: P
authors.lastname: Ventosilla
authors.affiliation: Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Minnick
authors.affiliation: ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic, Universitat de Barcelona, 08036 Barcelona, Spain.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Ruiz
authors.affiliation: Instituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima 31, Peru.
authors.forename: Ciro
authors.initials: C
authors.lastname: Maguiña