title: Understanding the biosynthesis of platelets-derived extracellular vesicles.
abstract: Platelet-derived extracellular vesicles (PEVs) are described as sub-cellular vesicles released into circulation upon platelets shear stress, activation, injury, or apoptosis. They are considered as universal biomarkers in a wide range of physiological and pathological processes. They are of tremendous significance for the prediction, diagnosis, and observation of the therapeutic success of many diseases. Understanding their biosynthesis and therefore functional properties would contribute to a better understanding of the pathological mechanisms leading to various diseases in which their levels are raised and they are implicated. The review takes a critical look at the historical background of PEVs, their structural components, the mechanism of their formation, physiological, and exogenous stimuli inducing their release and their detection. It concludes by highlighting on the importance of undertaking in-depth studies into PEVs biosynthesis and subsequently gaining a better understanding of their biological role in general.
authors.affiliation: Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana 143, Korle-Bu, Accra, Ghana.
authors.forename: Samuel
authors.initials: S
authors.lastname: Antwi-Baffour
authors.affiliation: Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana 143, Korle-Bu, Accra, Ghana.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Adjei
authors.affiliation: Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana 143, Korle-Bu, Accra, Ghana.
authors.forename: Claudia
authors.initials: C
authors.lastname: Aryeh
authors.affiliation: Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana 143, Korle-Bu, Accra, Ghana.
authors.forename: Ransford
authors.initials: R
authors.lastname: Kyeremeh
authors.affiliation: College of Agriculture and Natural Sciences, School of Biological Sciences, Department of Molecular Biology and Biotechnology, University of Cape Coast Cape Coast, Ghana.
authors.forename: Foster
authors.initials: F
authors.lastname: Kyei
authors.affiliation: Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana 143, Korle-Bu, Accra, Ghana.
authors.forename: Mahmood A
authors.initials: MA
authors.lastname: Seidu
keywords: Actin; biomarkers; centrifugation; extracellular vesicles; phosphatidylserine; phospholipids