title: Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads.
abstract: In recent years, the studies on the roles of caffeic acid phenethyl ester (CAPE) in several disease models and cell cultures are tremendously growing. It is such a great molecule that was used by ancient times to ameliorate some diseases and nowadays, it is used by modern medicine to test the effectiveness. In this mini-review article, the protection capability of CAPE, as a liposoluble antioxidant and a potent nuclear factor kappa B inhibitor, on oxidative and non-oxidative ovary, and testis damages has been summarized. In view of our laboratory findings/experience and those reported in the hitherto literature, we suggest that CAPE possesses protective effects for pathologies of the reproductive organs induced by untoward effects of harmful molecules such as free oxygen radicals, pesticides, methotrexate, and MK-801 (dizocilpine).
authors.affiliation: Departments of Medical Biology, Faculty of Turgut Ozal University Medical, Ankara, Turkey ; Department of Biochemistry, Faculty of Gaziosmanpasa University Medical, Tokat, Turkey.
authors.forename: Sumeyya
authors.initials: S
authors.lastname: Akyol
authors.affiliation: Department of Biochemistry, Faculty of Gaziosmanpasa University Medical, Tokat, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Akbas
authors.affiliation: Department of Biochemistry, Faculty of Gaziosmanpasa University Medical, Tokat, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Butun
authors.affiliation: Department of Anatomy, Faculty of Turgut Ozal University Medical, Ankara, Turkey.
authors.forename: Muhsin
authors.initials: M
authors.lastname: Toktas
authors.affiliation: Department of Biochemistry, Faculty of Gaziosmanpasa University Medical, Tokat, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ozyurt
authors.affiliation: Department of Biochemistry, Faculty of Gaziosmanpasa University Medical, Tokat, Turkey.
authors.forename: Semsettin
authors.initials: S
authors.lastname: Sahin
authors.affiliation: Department of Biochemistry, Faculty of Hacettepe University Medical, Ankara, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Akyol
keywords: Caffeic acid phenethyl ester; gonads; ovary; oxidative damage; protection; testis