title: Mesenchymal Stem Cells and Cell Therapy for Bone Repair.
abstract: Mesenchymal stem cells (MSCs) represent a new therapeutic paradigm for a number of diseases because they possess unique biological characteristics such as multipotency, immunomodulation and production of cytokines. Currently, 425 MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating the safety and efficacy of MSCs. Here, we provide an overview of the clinical status of MSCs by searching the public clinical trials database http://clinicaltrials.gov. Particularly, the role of MSCs in clinical trials to treat bone defects and injuries is highlighted.
authors.forename: Shihua
authors.initials: S
authors.lastname: Wang
authors.forename: Pengchao
authors.initials: P
authors.lastname: Xu
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Li
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Su
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Wan
authors.forename: Linyuan
authors.initials: L
authors.lastname: Fan
authors.forename: Kan
authors.initials: K
authors.lastname: Yin
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Peking Union Medical College Hospital, Center of Excellence in Tissue Engineering Chinese Academy of Medical Sciences, Beijing, China. China.
authors.forename: Robert Chunhua
authors.initials: RC
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D002986:Clinical Trials as Topic; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D014945:Wound Healing