title: IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer.
abstract: Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.
authors.affiliation: Gray Institute for Radiation Oncology and Biology; Department of Oncology; University of Oxford ; Oxford, UK.
authors.forename: Serena
authors.initials: S
authors.lastname: Lunardi
authors.affiliation: Gray Institute for Radiation Oncology and Biology; Department of Oncology; University of Oxford ; Oxford, UK.
authors.forename: Su Yin
authors.initials: SY
authors.lastname: Lim
authors.affiliation: Gray Institute for Radiation Oncology and Biology; Department of Oncology; University of Oxford ; Oxford, UK ; These authors contributed equally to this work.
authors.forename: Ruth J
authors.initials: RJ
authors.lastname: Muschel
authors.affiliation: Gray Institute for Radiation Oncology and Biology; Department of Oncology; University of Oxford ; Oxford, UK ; Department of Radiation Oncology; University Hospitals Freiburg ; Freiburg, Germany ; These authors contributed equally to this work.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Brunner
keywords: CXCL10; IP-10; pancreatic cancer; pancreatic stellate cells; regulatory T cells