title: Mitochondria Cripple without Krüppel.
abstract: Proper mitochondrial biogenesis and removal is crucial in maintaining a healthy heart. Liao et al now show key roles for cardiac KLF4 in mitochondrial homeostasis via its interaction with the ERR/PGC-1 module, and mitochondrial clearance via regulation of mitophagy. Disruption of KLF4 leads to profoundly injured mitochondria and cardiac failure.
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, 3400 Civic Blvd, Philadelphia PA 19104, USA; Harvard Medical School, 330 Brookline Ave, Boston MA 02215, USA.
authors.forename: Cholsoon
authors.initials: C
authors.lastname: Jang
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, 3400 Civic Blvd, Philadelphia PA 19104, USA. Electronic address: zarany@mail.med.upenn.edu.
authors.forename: Zolt
authors.initials: Z
authors.lastname: Arany
mesh_terms: D000818:Animals; D006801:Humans; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors