title: There is Kisspeptin - And Then There is Kisspeptin.
abstract: While kisspeptin was initially found to function as a metastasis suppressor, after identification of its receptor KISS1R and their expression profiles in tissues such as the hypothalamus and adrenals, kisspeptin and KISS1R were predominantly assigned endocrine functions, including regulating puberty and fertility through their actions on hypothalamic gonadotropin releasing hormone production. More recently, an alter ego for kisspeptin has emerged, with a significant role in regulating glucose homeostasis, insulin secretion, as well as food intake and body composition, and deficient kisspeptin signaling results in reduced locomotor activity and increased adiposity. This review highlights these recent observations on the role of kisspeptin in metabolism as well as several key questions that need to be addressed in the future.
authors.affiliation: Divisions of Metabolism and Pediatric Endocrinology, Departments of Medicine, Pediatrics, Biological Chemistry and Physiology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: mhussai4@jhmi.edu.
authors.forename: Mehboob A
authors.initials: MA
authors.lastname: Hussain
authors.affiliation: Divisions of Metabolism and Pediatric Endocrinology, Departments of Medicine, Pediatrics, Biological Chemistry and Physiology, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Woo-Jin
authors.initials: WJ
authors.lastname: Song
authors.affiliation: Divisions of Metabolism and Pediatric Endocrinology, Departments of Medicine, Pediatrics, Biological Chemistry and Physiology, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Wolfe
mesh_terms: D000818:Animals; D005260:Female; D005934:Glucagon / Q000235:genetics / Q000378:metabolism; D006801:Humans; D059648:Kisspeptins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D012528:Satiety Response / Q000502:physiology
chemical_list: D059648:Kisspeptins; D043562:Receptors, G-Protein-Coupled; D005934:Glucagon
keywords: Kisspeptin; glucagon; insulin; obesity; satiety; sexual dimorphism