title: Progress on the relationship between miR-125 family and tumorigenesis.
abstract: miRNA-125 family, which is a highly conserved miRNA family throughout evolution, is consist of miRNA-125a-3p, miRNA-125a-5p, miRNA-125b-1 and miRNA-125b-2.The aberrant expression of miR-125 familyis tightly related to tumorigenesis and tumor development. The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al. Through regulating these downstream targets miR-125 family is involved in regulating tumorigenesis and tumor development. Nowadays, miR-125b have already became a putative and valuable biomarker for cancer diagnosis, treatment and prognosis. In this review, we mainly summarize the dual function of miRNA-125 family in suppression and promotion of cancer cells and further elaborate its regulatory mechanisms from four facets, proliferation, apoptosis, invasion or metastasis and immune response.
authors.affiliation: Dalian 24 High School, Dalian 116023, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Neurosurgery, The Second Afiliated Hospital of Dalian Medical University, Dalian 116023, China.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, The Second Afiliated Hospital of Dalian Medical University, Dalian 116023, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
authors.forename: Jeiyoun
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Ultrasonography, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China.
authors.forename: Yuanyang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pathophysiology, Dalian Medical University, Dalian 116044, China.
authors.forename: Molin
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The Second Afiliated Hospital of Dalian Medical University, Dalian 116023, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yin
authors.affiliation: Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The Second Afiliated Hospital of Dalian Medical University, Dalian 116023, China. Electronic address: weiminghai1765@163.com.
authors.forename: Minghai
authors.initials: M
authors.lastname: Wei
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D006801:Humans; D035683:MicroRNAs / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D035683:MicroRNAs
keywords: MiR-125 family; Regulatory mechanism; Target genes; Tumor