title: Contribution of chaperones to STAT pathway signaling.
abstract: Aberrant STAT signaling is associated with the development and progression of many cancers and immune related diseases. Recent findings demonstrate that proteostasis modulators under clinical investigation for cancer therapy have a significant impact on STAT signaling, which may be critical for mediating their anti-cancer effects. Chaperones are critical for protein folding, stability and function and, thus, play an essential role in the maintenance of proteostasis. In this review we discuss the role of chaperones in STAT and tyrosine kinase (TK) protein folding, modulation of STAT and TK activity, and degradation of TKs. We highlight the important role of chaperones in STAT signaling, and how this knowledge has provided a framework for the development of new therapeutic avenues of targeting STAT signaling related pathologies.
authors.affiliation: Section of Infectious Disease; Department of Pediatrics; Baylor College of Medicine ; Houston, TX USA.
authors.forename: Claire E
authors.initials: CE
authors.lastname: Bocchini
authors.affiliation: Section of Infectious Disease; Department of Medicine; Baylor College of Medicine ; Houston, TX USA.
authors.forename: Moses M
authors.initials: MM
authors.lastname: Kasembeli
authors.affiliation: Department of Biochemistry & Molecular Biology; Baylor College of Medicine ; Houston, TX USA.
authors.forename: Soung-Hun
authors.initials: SH
authors.lastname: Roh
authors.affiliation: Section of Infectious Disease; Department of Medicine; Baylor College of Medicine ; Houston, TX USA ; Department of Biochemistry & Molecular Biology; Baylor College of Medicine ; Houston, TX USA ; Department of Molecular & Cellular Biology; Baylor College of Medicine ; Houston, TX USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Tweardy
keywords: JAK; RTK; SRC; STAT; chaperone; chaperonin; heat shock proteins; tyrosine kinase