title: Quantitative imaging of light-triggered doxorubicin release.
abstract: The efficacy of chemotherapy is related, in large part, to the concentration of drug that reaches tumor sites. Doxorubicin (DOX) is a common anti-cancer drug that is also approved for use in liposomal form for the treatment of ovarian cancer. We recently developed a porphyrin-phospholipid (PoP)-liposome system that enables on demand release of DOX from liposomes using near infrared irradiation to improve DOX bioavailability. Owing to its intrinsic fluorescence, it is possible, and desirable, to quantify DOX concentration and distribution, preferably noninvasively. Here we quantified DOX distribution following light-triggered drug release in phantoms and an animal carcass using spatial frequency domain imaging. This study demonstrates the feasibility of non-invasive quantitative mapping of DOX distributions in target areas.
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA ; Department of Biomedical, Industrial & Human Factors Engineering, Wright State University, Dayton, OH, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Kress
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA ; Department of Biomedical, Industrial & Human Factors Engineering, Wright State University, Dayton, OH, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rohrbach
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Carter
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA.
authors.forename: Dandan
authors.initials: D
authors.lastname: Luo
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA.
authors.forename: Shuai
authors.initials: S
authors.lastname: Shao
authors.affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Shashikant
authors.initials: S
authors.lastname: Lele
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA.
authors.forename: Jonathan F
authors.initials: JF
authors.lastname: Lovell
authors.affiliation: Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA ; Department of Biomedical, Industrial & Human Factors Engineering, Wright State University, Dayton, OH, USA.
authors.forename: Ulas
authors.initials: U
authors.lastname: Sunar
keywords: (170.0110) Imaging systems; (170.0170) Medical optics and biotechnology; (170.3880) Medical and biological imaging; (170.6935) Tissue characterization