title: Ischaemic stroke: decide rapidly.
abstract: A meta-analysis of individual data for 6756 patients showed that intravenous thrombolysis with alteplase improved survival without overt neurological deficits when started within 4.5 hours of the first symptoms of ischaemic stroke, at a cost of increased mortality due to cerebral haemorrhage during the week following thrombolysis.
mesh_terms: D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000401:mortality; D004334:Drug Administration Schedule; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D015201:Meta-Analysis as Topic; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D061665:Time-to-Treatment; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator