title: Association between immunoreactivity to Anisakis spp. antigens and high-risk pregnancy.
abstract: Numerous factors contribute to perinatal risk, many of which remain undefined. This study sought to determine the frequency of fish intake in postpartum women, and to establish a relationship between the rates of immunoreactivity for antigens from Anisakis spp. and high-risk pregnancy. In this prospective noninterventional study, a structured questionnaire was administered and serum was collected from postpartum women at two perinatal centers (a high-risk birth unit [HRBU] and a low-risk birth unit [LRBU]) in the Niteroi municipality of Brazil. Anisakis species-specific IgG and IgE were measured by ELISA. The chisquared test was performed, and odds ratios (ORs) with their 95% confidence intervals were estimated. The t-test or Mann-Whitney test was applied to continuous, normally distributed variables. In total, 309 women (170 from HRBU, 139 from LRBU) between 24.8 and 26.7 years old with a median of 6 to 8 prenatal visits were enrolled. Women in the two units exhibited differences in some variables, including prenatal care (p = 0.01), maternal and fetal risk (p = 0.00; OR = 6.17), and gestational age (p = 0.00), but no differences in fish consumption (p = 0.29), frequency of fish intake (p = 0.40), allergic symptoms (p = 0.51), or frequency of anti-Anisakis reactivity (p = 0.22). Logistic regression analysis revealed that only age was independently associated with postpartum anti-Anisakis reactivity. This study confirmed a low prevalence of fish intake and suggested that Anisakis spp. had no impact on high-risk pregnancies among this postpartum study population.
authors.forename: Israel
authors.initials: I
authors.lastname: Figueiredo
authors.forename: Mauricio
authors.initials: M
authors.lastname: Vericimo
authors.forename: Luciana
authors.initials: L
authors.lastname: Terra
authors.forename: Taylane
authors.initials: T
authors.lastname: Ferreira
authors.forename: Sergio Carmona
authors.initials: SC
authors.lastname: São Clemente
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Teixeira
mesh_terms: D000818:Animals; D017129:Anisakiasis / Q000175:diagnosis* / Q000453:epidemiology / Q000469:parasitology; D017163:Anisakis / Q000276:immunology / Q000302:isolation & purification*; D000947:Antigens, Helminth / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000175:diagnosis* / Q000469:parasitology; D018566:Pregnancy, High-Risk; D015995:Prevalence; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D000947:Antigens, Helminth; D007074:Immunoglobulin G; D007073:Immunoglobulin E