title: Physical Activity and Risk of Male Breast Cancer.
abstract: The association between leisure-time physical activity (LTPA) and male breast cancer risk is unclear. In the Male Breast Cancer Pooling Project, with 449 cases and 13,855 matched controls, we used logistic regression with study stratification to generate adjusted ORs and 95% confidence intervals (CI) for LTPA tertiles and male breast cancer risk. Compared with low LTPA, medium and high LTPA were not associated with male breast cancer risk (OR, 1.01; 95% CI, 0.79-1.29; 0.90, 0.69-1.18, respectively). In joint-effects analyses, compared with the referent of high body mass index (BMI; ≥25 kg/m(2))/low LTPA, neither medium nor high PA was associated with risk among high BMI men, but normal BMI men (<25 kg/m(2)) with low or medium LTPA were at a nonsignificant ∼16% reduced risk and those with high LTPA were at a 27% reduced risk (OR, 0.73; 95% CI, 0.50-1.07). Physical activity alone may not confer protection against male breast cancer risk.
authors.affiliation: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland. Aremhe2@mail.nih.gov.
authors.forename: Hannah
authors.initials: H
authors.lastname: Arem
authors.affiliation: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland.
authors.forename: Louise A
authors.initials: LA
authors.lastname: Brinton
authors.affiliation: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Moore
authors.affiliation: American Cancer Society, Atlanta, Georgia.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gapstur
authors.affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, California.
authors.forename: Laurel A
authors.initials: LA
authors.lastname: Habel
authors.affiliation: Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Johnson
authors.affiliation: Cancer Research Center of Hawaii, Honolulu, Hawaii.
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Valerie A
authors.initials: VA
authors.lastname: McCormack
authors.affiliation: Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Karin B
authors.initials: KB
authors.lastname: Michels
authors.affiliation: Divisions of Preventive Medicine and Aging, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Howard D
authors.initials: HD
authors.lastname: Sesso
authors.affiliation: Cancer Registry of Norway, Oslo, Norway.
authors.forename: Giske
authors.initials: G
authors.lastname: Ursin
authors.affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, California.
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Van Den Eeden
authors.affiliation: Cancer Registry of Norway, Oslo, Norway. Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden. Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.
authors.forename: Elisabete
authors.initials: E
authors.lastname: Weiderpass
authors.affiliation: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Cook
authors.affiliation: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Matthews
mesh_terms: D018567:Breast Neoplasms, Male / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D015331:Cohort Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D012307:Risk Factors