title: Baclofen and pregnancy: birth defects and withdrawal symptoms.
abstract: A comparison of 134 pregnant women who had taken baclofen in early pregnancy and 400 pregnant controls showed an increased risk of major malformations. Several infants exposed to baclofen until birth exhibited withdrawal symptoms.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001418:Baclofen / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000633:toxicity*; D009357:Neonatal Abstinence Syndrome / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen