title: Stimulation of In Vivo Antitumor Immunity with Hollow Mesoporous Silica Nanospheres.
abstract: The use of appropriate adjuvants that support the generation of robust and long-lasting antitumor immune responses is crucial for tumor immunotherapy owing to the immunosuppressive environment of the growing tumor. However, the most commonly used adjuvant, aluminum hydroxide, is ineffective for generating such immune responses and therefore not suitable for cancer immunotherapy. It is now shown that plain hollow mesoporous silica nanospheres markedly improve the antitumor immunity, the Th1 and Th2 immunity, and the CD4(+) and CD8(+) effector memory T cell population in bone marrow in vivo and may thus be used as immunoadjuvants to treat cancer in humans.
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan. xp-wang@aist.go.jp.
authors.forename: Xiupeng
authors.identifier: http://orcid.org/0000-0001-7737-384X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ito
authors.affiliation: Biomedical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sogo
authors.affiliation: Biomedical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Noriko M
authors.initials: NM
authors.lastname: Tsuji
authors.affiliation: School of Life Dentistry at Tokyo, The Nippon Dental University, Fujimi, Chiyoda-ku Tokyo, 102-0071, Japan.
authors.forename: Tadao
authors.initials: T
authors.lastname: Ohno
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D054118:Nanospheres; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D012822:Silicon Dioxide
keywords: adjuvants; antitumor immunity; cancer; immune memory; silica nanospheres