title: Bone Mineral Density and Fracture Risk Assessment to Optimize Prosthesis Selection in Total Hip Replacement.
abstract: The variability in patient outcome and propensity for surgical complications in total hip replacement (THR) necessitates the development of a comprehensive, quantitative methodology for prescribing the optimal type of prosthetic stem: cemented or cementless. The objective of the research presented herein was to describe a novel approach to this problem as a first step towards creating a patient-specific, presurgical application for determining the optimal prosthesis procedure. Finite element analysis (FEA) and bone mineral density (BMD) calculations were performed with ten voluntary primary THR patients to estimate the status of their operative femurs before surgery. A compilation model of the press-fitting procedure was generated to define a fracture risk index (FRI) from incurred forces on the periprosthetic femoral head. Comparing these values to patient age, sex, and gender elicited a high degree of variability between patients grouped by implant procedure, reinforcing the notion that age and gender alone are poor indicators for prescribing prosthesis type. Additionally, correlating FRI and BMD measurements indicated that at least two of the ten patients may have received nonideal implants. This investigation highlights the utility of our model as a foundation for presurgical software applications to assist orthopedic surgeons with selecting THR prostheses.
authors.affiliation: Institute for Biomedical and Neural Engineering, Háskólinn í Reykjavík, Menntavegur 1, 101 Reykjavík, Iceland.
authors.forename: Þröstur
authors.initials: Þ
authors.lastname: Pétursson
authors.affiliation: Institute for Biomedical and Neural Engineering, Háskólinn í Reykjavík, Menntavegur 1, 101 Reykjavík, Iceland.
authors.forename: Kyle Joseph
authors.initials: KJ
authors.lastname: Edmunds
authors.affiliation: Institute for Biomedical and Neural Engineering, Háskólinn í Reykjavík, Menntavegur 1, 101 Reykjavík, Iceland.
authors.forename: Magnús Kjartan
authors.initials: MK
authors.lastname: Gíslason
authors.affiliation: Institute for Biomedical and Neural Engineering, Háskólinn í Reykjavík, Menntavegur 1, 101 Reykjavík, Iceland.
authors.forename: Benedikt
authors.initials: B
authors.lastname: Magnússon
authors.affiliation: Department of Rehabilitation, Landspítali, Norðurmýri, 101 Reykjavík, Iceland.
authors.forename: Gígja
authors.initials: G
authors.lastname: Magnúsdóttir
authors.affiliation: Department of Rehabilitation, Landspítali, Norðurmýri, 101 Reykjavík, Iceland.
authors.forename: Grétar
authors.initials: G
authors.lastname: Halldórsson
authors.affiliation: Institute for Biomedical and Neural Engineering, Háskólinn í Reykjavík, Menntavegur 1, 101 Reykjavík, Iceland ; Orthopaedic Clinic, Landspitali Hospital, Norðurmýri, 101 Reykjavík, Iceland ; Medical Faculty, Háskóli Íslands, Sæmundargötu 2, 101 Reykjavík, Iceland.
authors.forename: Halldór
authors.initials: H
authors.lastname: Jónsson
authors.affiliation: Institute for Biomedical and Neural Engineering, Háskólinn í Reykjavík, Menntavegur 1, 101 Reykjavík, Iceland ; Department of Science, Landspítali University Hospital, Norðurmýri, 101 Reykjavík, Iceland.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gargiulo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000295:instrumentation*; D001843:Bone Cements; D015519:Bone Density; D005260:Female; D005264:Femoral Fractures / Q000209:etiology / Q000517:prevention & control; D005270:Femur Head / Q000000981:diagnostic imaging; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D008953:Models, Anatomic; D008954:Models, Biological; D015233:Models, Statistical; D011474:Prosthesis Design; D011475:Prosthesis Failure; D018570:Risk Assessment; D012984:Software; D014057:Tomography, X-Ray Computed
chemical_list: D001843:Bone Cements