title: Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C-N Coupling with Chiral Bisphosphine Mono-oxides.
abstract: A novel approach to hemiaminal synthesis via palladium-catalyzed C-N coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir, and has been applied to the synthesis of chiral N,N-acetals.
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Hongming
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Belyk
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Jingjun
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Qinghao
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Alan
authors.initials: A
authors.lastname: Hyde
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Yining
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Steven
authors.initials: S
authors.lastname: Oliver
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Tudge
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Louis-Charles
authors.initials: LC
authors.lastname: Campeau
authors.affiliation: Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Campos