title: Blumea balsamifera Oil for the Acceleration of Healing of Burn Injuries.
abstract: Blumea balsamifera oil (BBO) is a main extract obtained from Blumea balsamifera (L.) DC (Ainaxiang) leaves, which are widely used as a traditional medicine by the Miao and Li Nations to promote skin trauma or burn injury healing. This study was initiated to investigate the healing efficacy in deep second-degree burn model in rats. The rats were treated by BBO for 21 consecutive days. The rate of healing, scabs dropped time and re-epithelialization time were observed every three days for 21 days after burn injury. The samples were collected from different treated rats by sacrificing the animals on the 1st, 2nd, 5th, 9th, 14th, and 21st day post-burn creation. Then, the water content of burn tissue was measured. Plasma interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α) levels were evaluated, and the tissue expressions of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and transforming growth factor-beta (TGF-β) were determined along with skin histopathology. The results showed that the water content of tissue was significantly reduced, the scabs dropped time shortened, and healing accelerated after treatment with BBO in the burn injury rats. Furthermore, the expressions of growth factors were significantly increased in the tissue; however, the levels of inflammatory factors on plasma decreased. This study confirms the efficacy of BBO consumption on burn injuries.
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. fujianfanzuowang@126.com.|School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. fujianfanzuowang@126.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. fujianfanzuowang@126.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. fujianfanzuowang@126.com.
authors.forename: Zuo-Wang
authors.initials: ZW
authors.lastname: Fan
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. blumeachina@126.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. blumeachina@126.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. blumeachina@126.com.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Pang
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. jimojijie29@163.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. jimojijie29@163.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. jimojijie29@163.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. fulai.yu@163.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. fulai.yu@163.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. fulai.yu@163.com.
authors.forename: Fu-Lai
authors.initials: FL
authors.lastname: Yu
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. wang_dan1414@163.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. wang_dan1414@163.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. wang_dan1414@163.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. yangquan7208@vip.163.com.
authors.forename: Quan
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. maqing_song@126.com.|School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. maqing_song@126.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. maqing_song@126.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. maqing_song@126.com.
authors.forename: Qing-Song
authors.initials: QS
authors.lastname: Ma
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. lxt2015cool@126.com.|School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. lxt2015cool@126.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. lxt2015cool@126.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. lxt2015cool@126.com.
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Li
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. zj602395791@126.com.|School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. zj602395791@126.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. zj602395791@126.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. zj602395791@126.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Zou
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. 13602428576@163.com.|School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. 13602428576@163.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. 13602428576@163.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. 13602428576@163.com.
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Zhang
authors.affiliation: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. w499494265n@126.com.|School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. w499494265n@126.com.|Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China. w499494265n@126.com.|Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China. w499494265n@126.com.
authors.forename: Li-Fen
authors.initials: LF
authors.lastname: Wu
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008297:Male; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D010938:Plant Oils / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D062326:Re-Epithelialization / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D009822:Oils, Volatile; D010938:Plant Oils
keywords: Blumea balsamifera (L.) oil (BBO); cytokine; deep second-degree burn; growth factor; inflammatory factor