title: Crystal structure of 4,6-di-amino-2,2-dimethyl-3-[3-(2,4,5-tri-chloro-phen-oxy)prop-oxy]-2,3-di-hydro-1,3,5-triazin-1-ium chloride methanol monosolvate.
abstract: In the title methanol-solvated salt, C14H19Cl3N5O2 (+)·Cl(-)·CH3OH, the triazine mol-ecule is protonated at one of the triazine N atoms. In the crystal, the triazine cations are linked through a pair of N-H⋯N hydrogen bonds, with graph-set R 2 (2)(8), forming an inversion dimer. The protonated N atom and the 2- and 4-amino groups of the triazine cation inter-act with the chloride anion through N-H⋯Cl hydrogen bonds, leading to the formation of a tape structure running along the b-axis direction. A short Cl⋯Cl contact [3.2937 (9) Å] is observed in the tape. The methanol mol-ecule is linked to the chloride anion and the triazine cation, respectively, by an O-H⋯Cl hydrogen bond and a C-H⋯O inter-action.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, and Center for Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Pattarapol
authors.initials: P
authors.lastname: Khongsuk
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, and Center for Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Samran
authors.initials: S
authors.lastname: Prabpai
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, and Center for Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Palangpon
authors.initials: P
authors.lastname: Kongsaeree
keywords: anti­folate drug; anti­malarial; crystal structure; hydrogen bonding; triazine