title: Lipid Composition, Fatty Acids and Sterols in the Seaweeds Ulva armoricana, and Solieria chordalis from Brittany (France): An Analysis from Nutritional, Chemotaxonomic, and Antiproliferative Activity Perspectives.
abstract: Lipids from the proliferative macroalgae Ulva armoricana (Chlorophyta) and Solieria chordalis (Rhodophyta) from Brittany, France, were investigated. The total content of lipids was 2.6% and 3.0% dry weight for U. armoricana and S. chordalis, respectively. The main fractions of S. chordalis were neutral lipids (37%) and glycolipids (38%), whereas U. armoricana contained mostly neutral lipids (55%). Polyunsaturated fatty acids (PUFA) represented 29% and 15% of the total lipids in U. armoricana and S. chordalis, respectively. In both studied algae, the phospholipids were composed of PUFA for 18%. In addition, PUFA were shown to represent 9% and 4.5% of glycolipids in U. armoricana and S. chordalis, respectively. The essential PUFA were 16:4n-3, 18:4n-3, 18:2n-3, 18:2n-6, and 22:6n-3 in U. armoricana, and 20:4n-6 and 20:5n-3 in S. chordalis. It is important to notice that six 2-hydroxy-, three 3-hydroxy-, and two monounsaturated hydroxy fatty acids were also identified and may provide a chemotaxonomic basis for algae. These seaweeds contained interesting compounds such as squalene, α-tocopherol, cholest-4-en-3-one and phytosterols. The antiproliferative effect was evaluated in vitro on human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) with an IC50 of 23 μg/mL for monogalactosyldiacylglycerols isolated from S. chordalis and 24 μg/mL for digalactosyldiacylglycerols from U. armoricana. These results confirm the potentialities of valorization of these two species in the fields of health, nutrition and chemotaxonomy.
authors.affiliation: University of South Brittany, EA 3884, LBCM, IUEM, F-56000 Vannes, France. melha.kendel@gmail.com.
authors.forename: Melha
authors.initials: M
authors.lastname: Kendel
authors.affiliation: Faculté des Sciences Pharmaceutiques et Biologiques, LUNAM, Université de Nantes, Groupe Mer-Molécules-Santé MMS, EA 2160, Institut Universitaire Mer et Littoral FR3473 CNRS, 9 Rue Bias, BP 53508, F-44035 Nantes Cedex 1, France.
authors.forename: Gaëtane
authors.initials: G
authors.lastname: Wielgosz-Collin
authors.affiliation: Faculté des Sciences Pharmaceutiques et Biologiques, LUNAM, Université de Nantes, Groupe Mer-Molécules-Santé MMS, EA 2160, Institut Universitaire Mer et Littoral FR3473 CNRS, 9 Rue Bias, BP 53508, F-44035 Nantes Cedex 1, France. samuel.bertrand@univ-nantes.fr.
authors.forename: Samuel
authors.initials: S
authors.lastname: Bertrand
authors.affiliation: Faculté des Sciences Pharmaceutiques et Biologiques, LUNAM Université, Université de Nantes, IICIMED/ERATU-EA 1155 Cancer du Poumon et Cibles Moléculaires, 1 Rue Gaston Veil, BP 53508, F-44035 Nantes Cedex 01, France. christos.roussakis@univ-nantes.fr.
authors.forename: Christos
authors.initials: C
authors.lastname: Roussakis
authors.affiliation: University of South Brittany, EA 3884, LBCM, IUEM, F-56000 Vannes, France. nathalie.bourgougnon@univ-ubs.fr.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bourgougnon
authors.affiliation: University of South Brittany, EA 3884, LBCM, IUEM, F-56000 Vannes, France. gilles.bedoux@univ-ubs.fr.
authors.forename: Gilles
authors.initials: G
authors.lastname: Bedoux
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry*; D005602:France; D008055:Lipids / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry*; D044445:Ulva / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005227:Fatty Acids; D008055:Lipids; D013261:Sterols
keywords: Solieria chordalis; Ulva armoricana; chemotaxonomy; fatty acids; glycolipids; human lung cancer; hydroxy fatty acids; phospholipids; polyunsaturated fatty acids; sterols