title: Elevated striatal reactivity across monetary and social rewards in bipolar I disorder.
abstract: Bipolar disorder (BD) is associated with increased reactivity to rewards and heightened positive affectivity. It is less clear to what extent this heightened reward sensitivity is evident across contexts and what the associated neural mechanisms might be. The present investigation used both a monetary and social incentive delay task among adults with remitted BD Type I (n = 24) and a healthy nonpsychiatric control group (HC; n = 25) using fMRI. Both whole-brain and region-of-interest analyses revealed elevated reactivity to reward receipt in the striatum, a region implicated in incentive sensitivity, in the BD group. Post hoc analyses revealed that greater striatal reactivity to reward receipt, across monetary and social reward tasks, predicted decreased self-reported positive affect when anticipating subsequent rewards in the HC but not in the BD group. Results point toward elevated striatal reactivity to reward receipt as a potential neural mechanism of persistent reward pursuit in BD.
authors.affiliation: Department of Psychology, Yale University.
authors.forename: Sunny J
authors.initials: SJ
authors.lastname: Dutra
authors.affiliation: Department of Psychology, University of Toronto.
authors.forename: William A
authors.initials: WA
authors.lastname: Cunningham
authors.affiliation: Department of Psychiatry, Yale University School of Medicine.
authors.forename: Hedy
authors.initials: H
authors.lastname: Kober
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado at Boulder.
authors.forename: June
authors.initials: J
authors.lastname: Gruber
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D003071:Cognition / Q000502:physiology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D065786:Delay Discounting / Q000502:physiology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D012201:Reward; D055815:Young Adult