title: Activity of Monoamine Oxidase in the Nigrostriatal System at Presymptomatic and Early Symptomatic Stages of Parkinsonism in Mice.
abstract: Activities of monoamine oxidases A and B were examined on the models of presymptomatic and early symptomatic stages of Parkinson's disease developed in mice treated with MPTP, a specific neurotoxin affecting dopaminergic neurons. Activity of monoamine oxidases A, the key enzyme of dopamine degradation, is increased in neuronal somas during the symptomatic stage, and it is augmented in the axons during both stages. Neuronal activity of monoamine oxidases A is higher during the symptomatic stage than that during the presymptomatic stage, which can explain depletion of intercellular dopamine and appearance of motor disturbances. Activity of monoamine oxidase B in the striatum is reduced during the presymptomatic stage, but returns to the control level during the symptomatic stage. Variation in monoamine oxidase activity seems to reflect the compensatory mechanisms triggered in degrading nigrostriatal dopaminergic system.
authors.affiliation: N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: G R
authors.initials: GR
authors.lastname: Khakimova
authors.affiliation: N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Kozina
authors.affiliation: V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Buneeva
authors.affiliation: V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Aksenova
authors.affiliation: V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Medvedev
authors.affiliation: N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia. mugryumov@mail.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Ugryumov
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D058070:Asymptomatic Diseases; D003342:Corpus Striatum / Q000201:enzymology; D008297:Male; D008810:Mice, Inbred C57BL; D008995:Monoamine Oxidase / Q000378:metabolism*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000201:enzymology*; D013378:Substantia Nigra / Q000201:enzymology*
chemical_list: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D008995:Monoamine Oxidase
keywords: MPTP, Parkinson’s disease; dopamine; mice; monoamine oxidase