title: The Association of Glucose Metabolism and Eigenvector Centrality in Alzheimer's Disease.
abstract: Both fluorine-18-labeled fluorodeoxyglucose ([(18)F]FDG) positron emission tomography, examining glucose metabolism, and resting-state functional magnetic resonance imaging (rs-fMRI), using covarying blood oxygen levels, can be used to explore neuronal dysfunction in Alzheimer's disease (AD). Both measures are reported to identify similar brain regions affected in AD patients. The spatial overlap and association of [(18)F]FDG with rs-fMRI in AD patients and controls were examined to investigate whether these two measures are associated, and if so, to what extent. For 24 AD patients and 18 controls, [(18)F]FDG and rs-fMRI data were available. [(18)F]FDG standardized uptake value ratios (SUVr), with cerebellar gray matter (GM) as reference tissue, were calculated. Eigenvector centrality (EC) mapping was used to spatially analyze the functional brain network. Group differences were calculated for [(18)F]FDG and eigenvector centrality mapping (ECM) values in four cortical regions (occipital, parietal, frontal, and temporal) and across voxels, with age, gender, and GM as covariates. Correlation of [(18)F]FDG with ECM was calculated within groups. Both lowered [(18)F]FDG SUVr and EC values were seen in the parietal and occipital cortex of AD patients. However, [(18)F]FDG yielded more robust and widespread brain areas affected in AD patients; hypometabolism was also observed in the temporal cortex and regions within frontal brain areas. Poor spatial overlap of both measures was observed. No associations were found between local [(18)F]FDG SUVr and ECM. In conclusion, agreement of [(18)F]FDG and ECM in AD patients seems moderate at best. [(18)F]FDG was most accurate in distinguishing AD patients from controls.
authors.affiliation: 1 Department of Radiology and Nuclear Medicine, VU University Medical Center , Amsterdam, The Netherlands .
authors.forename: Sofie M
authors.initials: SM
authors.lastname: Adriaanse
authors.affiliation: 1 Department of Radiology and Nuclear Medicine, VU University Medical Center , Amsterdam, The Netherlands .
authors.forename: Alle Meije
authors.initials: AM
authors.lastname: Wink
authors.affiliation: 2 Department of Neurology and Alzheimer Center, VU University Medical Center , Amsterdam, The Netherlands .
authors.forename: Betty M
authors.initials: BM
authors.lastname: Tijms
authors.affiliation: 1 Department of Radiology and Nuclear Medicine, VU University Medical Center , Amsterdam, The Netherlands .|2 Department of Neurology and Alzheimer Center, VU University Medical Center , Amsterdam, The Netherlands .
authors.forename: Rik
authors.initials: R
authors.lastname: Ossenkoppele
authors.affiliation: 2 Department of Neurology and Alzheimer Center, VU University Medical Center , Amsterdam, The Netherlands .
authors.forename: Sander C J
authors.initials: SC
authors.lastname: Verfaillie
authors.affiliation: 1 Department of Radiology and Nuclear Medicine, VU University Medical Center , Amsterdam, The Netherlands .
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Lammertsma
authors.affiliation: 1 Department of Radiology and Nuclear Medicine, VU University Medical Center , Amsterdam, The Netherlands .
authors.forename: Ronald
authors.initials: R
authors.lastname: Boellaard
authors.affiliation: 2 Department of Neurology and Alzheimer Center, VU University Medical Center , Amsterdam, The Netherlands .
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
authors.affiliation: 1 Department of Radiology and Nuclear Medicine, VU University Medical Center , Amsterdam, The Netherlands .
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D000814:Aniline Compounds / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000378:metabolism
chemical_list: D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: Alzheimer's disease; brain metabolism; graph theory; positron emission tomography; resting-state functional connectivity fMRI