title: Liposomal Bupivacaine: A Comparative Study of More Than 1000 Total Joint Arthroplasty Cases.
abstract: Pain after total joint arthroplasty (TJA) can be severe and difficult to control. A single-dose local analgesic delivers bupivacaine in a liposomal time-release platform. In 2248 consecutive patients with hip and knee arthroplasty, half (Pre) were treated using a well-established multimodal analgesia, including periarticular injection (PAI), and half had the PAI substituted for a liposomal bupivacaine injection technique (Post). Pain scores were significantly lower for patients in the Post group for both hip and knee procedures. A large series of patients who had TJA experienced pain relief after the introduction of liposomal bupivacaine as part of an established multimodal protocol.
authors.affiliation: Plano Orthopedic Sports Medicine & Spine Center, 5228 W Plano Pkwy, Plano, TX 75093, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Barrington
authors.affiliation: Texas Center for Joint Replacement, 6020 West Parker Road, Suite 470, Plano, TX 75093, USA.
authors.forename: Oluseun
authors.initials: O
authors.lastname: Olugbode
authors.affiliation: Exponent, Inc, 149 Commonwealth Drive, Menlo Park, CA 94025, USA. Electronic address: slovald@exponent.com.
authors.forename: Scott
authors.initials: S
authors.lastname: Lovald
authors.affiliation: Exponent, Inc, 3440 Market Street, Suite 600, Philadelphia, PA 19104, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Ong
authors.affiliation: Exponent, Inc, 149 Commonwealth Drive, Menlo Park, CA 94025, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Watson
authors.affiliation: Texas Center for Joint Replacement, 6020 West Parker Road, Suite 470, Plano, TX 75093, USA.
authors.forename: Roger H
authors.initials: RH
authors.lastname: Emerson
mesh_terms: D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage*; D050806:Arthroplasty, Replacement, Finger; D019645:Arthroplasty, Replacement, Knee; D002045:Bupivacaine / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D000779:Anesthetics, Local; D003692:Delayed-Action Preparations; D008081:Liposomes; D002045:Bupivacaine
keywords: Analgesia; Hip arthroplasty; Knee arthroplasty; Liposomal bupivacaine; Pain control