title: Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case.
abstract: A 43-year-old Japanese woman visited for a hepatic tumor incidentally found. We suspected eosinophilic granuloma of the liver (EGL) due to visceral larva migrans (VLM). However, neither past history nor medical interview indicated a risk of parasitosis. Blood testing revealed eosinophilia, serum examination showed normal results for immunoglobulin E, and enzyme-linked immunosorbent assay yielded negative for Toxocara and Anisakis. Gastric and colonic endoscopy revealed normal features. Several imagings showed central necrosis of the tumor. After informed consent, laparoscopic resection was performed. Histopathological examination showed EGL without parasites. No recurrence had occurred postoperatively. Most reports documented that EGL are caused by VLM. However, parasites are not always demonstrable on serum, histopathological, or immunochemical examinations. When acting as allergens to induce type I responses, microscopic agents other than parasites in the intestinal tract could induce eosinophilic inflammation in the liver. Accumulation of more cases should help clarify other pathogeneses for EGL.
authors.affiliation: 1 Department of Surgery and.
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: 1 Department of Surgery and.
authors.forename: Toru
authors.initials: T
authors.lastname: Miyazaki
authors.affiliation: 1 Department of Surgery and.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kurashima
authors.affiliation: 1 Department of Surgery and.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ohata
authors.affiliation: 1 Department of Surgery and.
authors.forename: Masato
authors.initials: M
authors.lastname: Okawa
authors.affiliation: 1 Department of Surgery and.
authors.forename: Shogo
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: 1 Department of Surgery and.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Uenishi
authors.affiliation: 2 Department of Gastroenterology, Ishikiri Seiki Hospital, Osaka, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Miyaji
authors.affiliation: 2 Department of Gastroenterology, Ishikiri Seiki Hospital, Osaka, Japan.
authors.forename: Nobusuke
authors.initials: N
authors.lastname: Fukumoto
mesh_terms: D000328:Adult; D000818:Animals; D003937:Diagnosis, Differential; D016099:Endoscopy, Gastrointestinal; D004797:Enzyme-Linked Immunosorbent Assay; D004803:Eosinophilic Granuloma / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D033162:Incidental Findings; D010535:Laparoscopy; D007816:Larva Migrans, Visceral / Q000150:complications; D008107:Liver Diseases / Q000175:diagnosis* / Q000601:surgery*
chemical_list: D007073:Immunoglobulin E
keywords: Eosinophilic granuloma of the liver; Hepatic granuloma; Parasitosis; Toxocara; Type I allergy