title: Stem cells and related factors involved in facial nerve function regeneration.
abstract: The facial nerve (VII) is one of the most important cranial nerves for head and neck surgeons. Its function is closely related to facial expressions that are individual for every person. After its injury or palsy, its functions can be either impaired or absent. Because of the presence of motor, sensory and parasympathetic fibers, the biology of its repair and function restoration depends on many factors. In order to achieve good outcome, many different therapies can be performed in order to restore as much of the nerve function as possible. When rehabilitation and physiotherapy are not sufficient, additional surgical procedures and therapies are taken into serious consideration. The final outcome of many of them is discussable, depending on nerve damage etiology. Stem cells in facial nerve repair are used, but long-term outcomes and results are still not fully known. In order to understand this therapeutic approach, clinicians and surgeons should understand the immunobiology of nerve repair and regeneration. In this review, potential stem cell usage in facial nerve regeneration procedures is discussed.
authors.affiliation: Department of Dental Anatomy, Medical University, Poland.
authors.forename: Kamil H
authors.initials: KH
authors.lastname: Nelke
authors.affiliation: Department of Maxillo-Facial Surgery, Wrocław Medical University, Poland.
authors.forename: Klaudiusz
authors.initials: K
authors.lastname: Łuczak
authors.affiliation: Department of Maxillo-Facial Surgery, Wrocław Medical University, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Pawlak
authors.affiliation: Department of Anesthesiology and Intensive Care Unit, Wrocław Medical University, Poland.
authors.forename: Lidia
authors.initials: L
authors.lastname: Łysenko
authors.affiliation: Department of Maxillo-Facial Surgery, Wrocław Medical University, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Gerber
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005154:Facial Nerve / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D009416:Nerve Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods; D013234:Stem Cells / Q000502:physiology*; D055815:Young Adult