title: Borinic acid catalysed peptide synthesis.
abstract: The catalytic synthesis of peptides is a major challenge in the modern organic chemistry hindered by the well-established use of stoichiometric coupling reagents. Herein, we describe for the first time that borinic acid is able to catalyse this reaction under mild conditions with an improved activity compared to our recently developed thiophene-based boronic acid. This catalyst is particularly efficient for peptide bond synthesis affording dipeptides in good yields without detectable racemization.
authors.affiliation: Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Normandie, CNRS, 6 boulevard du Maréchal Juin, 14050 Caen, France. jerome.blanchet@ensicaen.fr.
authors.forename: Tharwat Mohy
authors.initials: TM
authors.lastname: El Dine
authors.affiliation: Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Normandie, CNRS, 6 boulevard du Maréchal Juin, 14050 Caen, France. jerome.blanchet@ensicaen.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Rouden
authors.affiliation: Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Normandie, CNRS, 6 boulevard du Maréchal Juin, 14050 Caen, France. jerome.blanchet@ensicaen.fr.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Blanchet
mesh_terms: D001889:Borinic Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010452:Peptide Biosynthesis; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001889:Borinic Acids; D010455:Peptides