title: Re-examination of genetic and nutritional factors related to trichothecene biosynthesis in Fusarium graminearum.
abstract: Disruption of two Fusarium genes that negatively regulate trichothecene biosynthesis was reported to cause a drastic increase in trichothecene production. However, careful inspection of these genes revealed that neither was significantly related to trichothecene production. Agmatine medium maintained the expression of trichothecene genes at significant levels, resulting in a 2-3-fold increase in the final yield, as compared to glutamine medium.
authors.affiliation: a Department of Biological Mechanisms and Functions , Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya , Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kitou
authors.affiliation: a Department of Biological Mechanisms and Functions , Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya , Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nakajima
authors.affiliation: a Department of Biological Mechanisms and Functions , Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya , Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Maeda
authors.affiliation: a Department of Biological Mechanisms and Functions , Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya , Japan.
authors.forename: Qi
authors.initials: Q
authors.lastname: Jin
authors.affiliation: b Division of Functional Genomics, Advanced Science Research Centre , Kanazawa University , Kanazawa , Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Nishiuchi
authors.affiliation: a Department of Biological Mechanisms and Functions , Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya , Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kanamaru
authors.affiliation: a Department of Biological Mechanisms and Functions , Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya , Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: a Department of Biological Mechanisms and Functions , Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya , Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kimura
mesh_terms: D000376:Agmatine / Q000378:metabolism / Q000494:pharmacology; D003470:Culture Media / Q000494:pharmacology; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism; D005670:Fusarium / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D005973:Glutamine / Q000378:metabolism / Q000494:pharmacology; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic; D014255:Trichothecenes / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D003470:Culture Media; D005656:Fungal Proteins; D014157:Transcription Factors; D014255:Trichothecenes; D005973:Glutamine; D000376:Agmatine
keywords: Tri6; agmatine; transcription regulator; trichothecene production