title: Polyunsaturated fatty acids and inflammation.
abstract: Inflammation is a protective process for life that aims to restore body homeostasis by targeting the injury and by inducing repair mechanisms. This process can also become excessive and lead to chronic inflammation and organ fibrosis. Polyunsaturated fatty acids play a key role in inflammatory processes and their resolution. Indeed, numerous lipid mediators derived from n-3 or n-6 PUFA such as eicosanoids, endocannabinoids, or proresolving lipids are able to target transcription factors to modulate gene expression. One other important action mechanism is by modification of cell membrane composition. The purpose of the present review is to describe the potential mechanisms by which PUFA influence inflammatory processes. To illustrate this purpose, we focused on the interactions between PUFA and intestinal inflammation as an integrative example.
authors.affiliation: INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 22, Boulevard Gambetta, Rouen Cedex, 76183, France.
authors.forename: Rachel
authors.initials: R
authors.lastname: Marion-Letellier
authors.affiliation: INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 22, Boulevard Gambetta, Rouen Cedex, 76183, France.|Department of Gastroenterology, Rouen University Hospital, 1 Rue De Germont, Rouen Cedex, 76031, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Savoye
authors.affiliation: Division of Gastroenterology, University of Calgary, AB, Canada.
authors.forename: Subrata
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D006801:Humans; D007249:Inflammation / Q000178:diet therapy* / Q000378:metabolism
chemical_list: D005231:Fatty Acids, Unsaturated
keywords: Colitis; Crohn's disease; G-protein-mediated signaling; NF-kB | AP-1; fatty acids; genetic models