title: [ROLE OF SEROTONIN IN THE REGULATION OF RESPIRATION AND BILE SECRETORY FUNCTION OF THE LIVER].
abstract: In acute experiments on laboratory male rats we have shown that serotonin (10 mkg/kg, intraportal) increased the oxygen consumption of by liver on 28.8% (P < 0.001) and reduced oxygen tension levels on 19.3% (P < 0.001). The action of serotonin on tissue respiration in liver realized through 5-HT(2) receptors because previous blockade by ketanserin (3 mg/kg) led to remove the effects of exogenous serotonin and inhibition of the action of endogenous autacoid. Serotonin reduced the amount of secreted bile on 13.5% (P < 0.05), and increases the concentration of conjugated bile acids and decreases the content of free cholate, indicating enhanced conjugation with taurine and glycine in the liver cells. However, serotonin didn't stimulate synthesis of primary bile acids. Introduction of serotonin in the conditions of 5-HT2 receptors blockade by ketanserin also led to speed decrease of bile secretion, but in this case stimulating effect of autacoid on bile acid conjugation with taurine and glycine wasn't manifested and content of free cholate wasn't reduced.
authors.forename: P I
authors.initials: PI
authors.lastname: Yanchuk
authors.forename: S M
authors.initials: SM
authors.lastname: Athamnah
authors.forename: E M
authors.initials: EM
authors.lastname: Reshetnik
authors.forename: J A
authors.initials: JA
authors.lastname: Levadyanska
authors.forename: N O
authors.initials: NO
authors.lastname: Nikitina
authors.forename: S P
authors.initials: SP
authors.lastname: Veselsky
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D019826:Cholic Acid / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D007275:Injections, Intravenous; D007650:Ketanserin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D011169:Portal Vein; D051381:Rats; D017208:Rats, Wistar; D044348:Receptors, Serotonin, 5-HT2 / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013654:Taurine / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D044348:Receptors, Serotonin, 5-HT2; D012702:Serotonin Antagonists; D013654:Taurine; D012701:Serotonin; D007650:Ketanserin; D019826:Cholic Acid; D005998:Glycine