title: Improvement of Desferrioxamine B Production of Streptomyces pilosus ATCC 19797 With Use of Protease Inhibitor and Minerals Related to Its Activity.
abstract: The relationship between protease and Desferal production was assayed. Experiments were performed using a cultivation of Streptomyces pilosus ATCC 19797 in soybean broth medium containing 2% soybean flour and 2% mannitol. The metabolism of the trihydroxamic acid sidrophore desferrioxamine B and protease production by a S. pilosus in nine continues days after culture were investigated as well as the effect of protease inhibitors was examined. It is found that the Desferal formation decreased with increased protease production. Also the effect of protease inhibitors and minerals in determined day of protease production in the culture medium by S. pilosus has been investigated.
authors.affiliation: Department of Pilot Biotechnology, Pasteur Institute of Iran, No. 358, 12 Farvardin Street, Pasteur Avenue, Pasteur Square, 13169-43551 Tehran, Iran.
authors.forename: Mehri
authors.initials: M
authors.lastname: Mortazavi
authors.affiliation: Department of Pilot Biotechnology, Pasteur Institute of Iran, No. 358, 12 Farvardin Street, Pasteur Avenue, Pasteur Square, 13169-43551 Tehran, Iran.
authors.forename: Azim
authors.initials: A
authors.lastname: Akbarzadeh
keywords: Deferrioxamine B production; Protease; Streptomyces pilosus