title: Implementation and validation of collapsed cone superposition for radiopharmaceutical dosimetry of photon emitters.
abstract: Two collapsed cone (CC) superposition algorithms have been implemented for radiopharmaceutical dosimetry of photon emitters. The straight CC (SCC) superposition method uses a water energy deposition kernel (EDKw) for each electron, positron and photon components, while the primary and scatter CC (PSCC) superposition method uses different EDKw for primary and once-scattered photons. PSCC was implemented only for photons originating from the nucleus, precluding its application to positron emitters. EDKw are linearly scaled by radiological distance, taking into account tissue density heterogeneities. The implementation was tested on 100, 300 and 600 keV mono-energetic photons and (18)F, (99m)Tc, (131)I and (177)Lu. The kernels were generated using the Monte Carlo codes MCNP and EGSnrc. The validation was performed on 6 phantoms representing interfaces between soft-tissues, lung and bone. The figures of merit were γ (3%, 3 mm) and γ (5%, 5 mm) criterions corresponding to the computation comparison on 80 absorbed doses (AD) points per phantom between Monte Carlo simulations and CC algorithms. PSCC gave better results than SCC for the lowest photon energy (100 keV). For the 3 isotopes computed with PSCC, the percentage of AD points satisfying the γ (5%, 5 mm) criterion was always over 99%. A still good but worse result was found with SCC, since at least 97% of AD-values verified the γ (5%, 5 mm) criterion, except a value of 57% for the (99m)Tc with the lung/bone interface. The CC superposition method for radiopharmaceutical dosimetry is a good alternative to Monte Carlo simulations while reducing computation complexity.
authors.affiliation: APHP-Service de médecine nucléaire, Hôpital Beaujon, F-92110 Clichy, France. INSERM U1149, Clichy, France.
authors.forename: Manuel
authors.initials: M
authors.lastname: Sanchez-Garcia
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gardin
authors.forename: Rachida
authors.initials: R
authors.lastname: Lebtahi
authors.forename: Arnaud
authors.initials: A
authors.lastname: Dieudonné
mesh_terms: D000465:Algorithms; D006801:Humans; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D017785:Photons / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals