title: Intussusception Cases Among Children Admitted to Referral Hospitals in Kenya, 2002-2013: Implications for Monitoring Postlicensure Safety of Rotavirus Vaccines in Africa.
abstract: To describe the epidemiology of intussusception before introduction of the rotavirus vaccine, we reviewed the records of 280 patients younger than 5 years who were hospitalized in Kenya between 2002 and 2013. The patients who died (18 [6.4%]) had sought care later after symptom onset than the patients who survived (median, 5 vs 3 days, respectively; P = .04). Seeking prompt care may improve therapeutic outcomes.
authors.affiliation: Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya.|Department of Epidemiology, School of Health Sciences, University of Tampere, Finland.
authors.forename: Richard
authors.initials: R
authors.lastname: Omore
authors.affiliation: Department of Surgery.
authors.forename: Francis
authors.initials: F
authors.lastname: Osawa
authors.affiliation: Department of Pediatrics and Child Health, School of Medicine, University of Nairobi, Kenya.
authors.forename: Janet
authors.initials: J
authors.lastname: Musia
authors.affiliation: Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Brian
authors.initials: B
authors.lastname: Rha
authors.affiliation: Division of Disease Surveillance and Response, Ministry of Public Health and Sanitation, Nairobi, Kenya.
authors.forename: Amina
authors.initials: A
authors.lastname: Ismail
authors.affiliation: Enteric Viruses Research Group, Institute of Primate Research, Nairobi, Kenya.
authors.forename: Nicholas Mukaria
authors.initials: NM
authors.lastname: Kiulia
authors.affiliation: Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya.
authors.forename: Fenny
authors.initials: F
authors.lastname: Moke
authors.affiliation: Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya.
authors.forename: John
authors.initials: J
authors.lastname: Vulule
authors.affiliation: Kenyatta National Hospital, Nairobi, Kenya.
authors.forename: Anthony Mungai
authors.initials: AM
authors.lastname: Wainaina
authors.affiliation: Aga Khan University Hospital, Nairobi, Kenya.
authors.forename: John
authors.initials: J
authors.lastname: Tole
authors.affiliation: Aga Khan University Hospital, Nairobi, Kenya.
authors.forename: Stanley Mugambi
authors.initials: SM
authors.lastname: Machoki
authors.affiliation: Department of Epidemiology, School of Health Sciences, University of Tampere, Finland.
authors.forename: J Pekka
authors.initials: JP
authors.lastname: Nuorti
authors.affiliation: Global Health Institute, Emory University, Atlanta, Georgia.|Global Disease Detection Division, Kenya Office of the US Centers for Disease Control and Prevention, Nairobi, Kenya.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Breiman
authors.affiliation: Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
authors.affiliation: Global Disease Detection Division, Kenya Office of the US Centers for Disease Control and Prevention, Nairobi, Kenya.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Montgomery
authors.affiliation: Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Tate
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000453:epidemiology* / Q000401:mortality; D007630:Kenya / Q000453:epidemiology; D008297:Male; D061214:Patient Safety; D011358:Product Surveillance, Postmarketing; D012017:Referral and Consultation; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000008:administration & dosage*
chemical_list: D022243:Rotavirus Vaccines
keywords: Kenya; childhood mortality; intussusception; risk factors