title: Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses.
abstract: We recently demonstrated that dual therapy combining AURKA and MDM2 antagonists is effective against melanoma in preclinical settings. Notably, besides inducing apoptosis, this regimen led to tumor senescence and stimulated the host's antitumor immune defenses. Treatments leveraging both cancer cell-intrinsic and extrinsic antitumor mechanisms can improve melanoma therapeutic outcomes.
authors.affiliation: Tennessee Valley Healthcare System; Department of Veterans Affairs , Nashville, TN USA ; Department of Cancer Biology; Vanderbilt University School of Medicine , Nashville, TN USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Vilgelm
authors.affiliation: Tennessee Valley Healthcare System; Department of Veterans Affairs , Nashville, TN USA ; Department of Cancer Biology; Vanderbilt University School of Medicine , Nashville, TN USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Richmond
keywords: Aurora kinase; apoptosis; melanoma; p53; senescence