title: Clinical Relevance of Different Handgrip Strength Indexes and Mobility Limitation in the Elderly Adults.
abstract: BACKGROUND
  More efficient clinical indexes are needed to identify older people most likely to present mobility impairments. The aim of the present study was to determine which handgrip strength (HS) indexes are clinically relevant to detect risk of mobility limitation in the elderly adults. In addition, we attempted to determine an optimal cutoff point for the most relevant index.
  
  
  METHODS
  Data are from 469 men and 609 women aged 60 years and older recruited in the Hangu area of Tianjin, China. Participants scoring in the top 20% on the Timed Up and Go Test or in the slowest 20% for the 4-m walk test were defined as having mobility limitation.
  
  
  RESULTS
  The prevalence of mobility limitation was 27.6% in women and 24.5% in men. The area under the receiver-operating characteristic curve for HS/body fat mass was 0.723 (95% confidence interval [CI] = 0.658-0.788) in men and for HS/weight was 0.684 (95% CI = 0.628-0.739) in women. These values were indicated higher levels of mobility limitation compared with HS and other relative HS indexes. The cutoffs of the most relevant index in men and women that effectively identified individuals at risk of mobility limitation were 1.884 and 0.281, respectively.
  
  
  CONCLUSIONS
  HS/body fat mass and HS/weight appear to be the indices best associated with mobility limitation for men and women, respectively. Optimal cutoffs for clinically relevant index have the potential to identify elderly adults at risk of mobility limitation.
authors.affiliation: Department of Rehabilitation Medicine, Cardiovascular Clinical College of Tianjin Medical University, TEDA International Cardiovascular Hospital, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Renwei
authors.initials: R
authors.lastname: Dong
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Xiuyang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Rehabilitation Medicine, Cardiovascular Clinical College of Tianjin Medical University, TEDA International Cardiovascular Hospital, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China. guoqijp@gmail.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Jiazhong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Suxing
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Han
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Li
authors.initials: L
authors.lastname: Kang
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Menglu
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Fu
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.
authors.forename: Liye
authors.initials: L
authors.lastname: Jia
authors.affiliation: Department of Rehabilitation Medicine, Tianjin Hospital, Tianjin, China.
authors.forename: Liancheng
authors.initials: L
authors.lastname: Wang
authors.affiliation: Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
authors.forename: Kaijun
authors.initials: K
authors.lastname: Niu
mesh_terms: D000273:Adipose Tissue; D000368:Aged; D000375:Aging / Q000502:physiology*; D015992:Body Mass Index; D001835:Body Weight; D002681:China / Q000453:epidemiology; D005080:Exercise Test / Q000379:methods; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D018737:Hand Strength; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D015995:Prevalence; D012372:ROC Curve; D018570:Risk Assessment / Q000379:methods
keywords: Aging; Mobility limitation; ROC analysis; Relative handgrip strength indexes