title: Platelet count combined with right liver volume and spleen volume measured by magnetic resonance imaging for identifying cirrhosis and esophageal varices.
abstract: OBJECTIVE
  To determine whether the combination of platelet count (PLT) with spleen volume parameters and right liver volume (RV) measured by magnetic resonance imaging (MRI) could predict the Child-Pugh class of liver cirrhosis and esophageal varices (EV).
  
  
  METHODS
  Two hundred and five cirrhotic patients with hepatitis B and 40 healthy volunteers underwent abdominal triphasic-enhancement MRI and laboratory examination of PLT in 10(9)/L. Cirrhotic patients underwent endoscopy for detecting EV. Spleen maximal width (W), thickness (T) and length (L) in mm together with spleen volume (SV) and RV in mm(3) were measured by MRI, and spleen volume index (SI) in mm(3) was obtained by W × T × L. SV/PLT, SI/PLT and RV × PLT/SV (RVPS) were calculated and statistically analyzed to assess cirrhosis and EV.
  
  
  RESULTS
  SV/PLT (r = 0.676) and SI/PLT (r = 0.707) increased, and PLT (r = -0.626) and RVPS (r = -0.802) decreased with the progress of Child-Pugh class (P < 0.001 for all). All parameters could determine the presence of cirrhosis, distinguish between each class of Child-Pugh class, and identify the presence of EV [the areas under the curve (AUCs) = 0.661-0.973]. Among parameters, RVPS could best determine presence and each class of cirrhosis with AUCs of 0.973 and 0.740-0.853, respectively; and SV/PLT could best identify EV with an AUC of 0.782.
  
  
  CONCLUSIONS
  The combination of PLT with SV and RV could predict Child-Pugh class of liver cirrhosis and identify the presence of esophageal varices.
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Chen
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Tian-Wu
authors.initials: TW
authors.lastname: Chen
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhang
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Zhen-Lin
authors.initials: ZL
authors.lastname: Li
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Nan-Lin
authors.initials: NL
authors.lastname: Zeng
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ren
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Xu
authors.affiliation: Xiao-Li Chen, Tian-Wu Chen, Xiao-Ming Zhang, Nan-Lin Zeng, Hang Li, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Jia-Ni
authors.initials: JN
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001792:Blood Platelets; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009929:Organ Size; D010976:Platelet Count; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013154:Spleen / Q000473:pathology*; D055815:Young Adult
keywords: Cirrhosis; Hepatic lobe; Magnetic resonance imaging; Platelet count; Spleen