title: Chlorhexidine-silver sulfadiazine- or rifampicin-miconazole-impregnated venous catheters decrease the risk of catheter-related bloodstream infection similarly.
abstract: BACKGROUND
  The objective of this study was to compare the incidence of catheter-related bloodstream infection (CRBSI) with the use of second-generation chlorhexidine-silver sulfadiazine (CHSS)-impregnated catheters, rifampicin-miconazole (RM)-impregnated catheters, and standard catheters.
  
  
  METHODS
  Retrospective study of patients admitted to an intensive care unit who received CHSS, RM, or standard catheters in femoral venous access.
  
  
  RESULTS
  We diagnosed 18 CRBSIs in 245 patients with standard catheters in 2,061 days, zero CRBSI in 169 patients with CHSS-impregnated catheters in 1,489 days, and zero CRBSI in 227 patients with RM-impregnated catheters in 2,009 days. Patients with standard catheters compared with CHSS- and RM-impregnated catheters showed a higher rate of CRBSI (7.3%, 0%, and 0%, respectively; P < .001) and higher incidence density of CRBSI (8.7, 0, and 0 per 1,000 catheter days, respectively; P < .001). We found in the exact Poisson regression that standard catheters were associated with a higher CRBSI incidence than CHSS-impregnated catheters (P < .001) and RM-impregnated catheters (P < .001), controlling for catheter duration. We found in survival analysis that standard catheters were associated with a lower CRBSI-free time than CHSS-impregnated catheters (P < .001) and RM-impregnated catheters (P < .001).
  
  
  CONCLUSIONS
  We found that CHSS- and RM-impregnated catheters decreased similarly the risk of CRBSI.
authors.affiliation: Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. Electronic address: lorentemartin@msn.com.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lorente
authors.affiliation: Department of Microbiology and Infection Control, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Lecuona
authors.affiliation: Research Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Jiménez
authors.affiliation: Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Raja
authors.affiliation: Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors.forename: Judith
authors.initials: J
authors.lastname: Cabrera
authors.affiliation: Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors.forename: Oswaldo
authors.initials: O
authors.lastname: Gonzalez
authors.affiliation: Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Diosdado
authors.affiliation: Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Marca
authors.affiliation: Department of Critical Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors.forename: María L
authors.initials: ML
authors.lastname: Mora
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D016470:Bacteremia / Q000517:prevention & control*; D055499:Catheter-Related Infections / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000379:methods; D062905:Central Venous Catheters / Q000009:adverse effects / Q000382:microbiology*; D002710:Chlorhexidine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D008297:Male; D008825:Miconazole / Q000008:administration & dosage; D008875:Middle Aged; D012189:Retrospective Studies; D012293:Rifampin / Q000008:administration & dosage; D012306:Risk; D012837:Silver Sulfadiazine / Q000008:administration & dosage
chemical_list: D000890:Anti-Infective Agents; D008825:Miconazole; D002710:Chlorhexidine; D012293:Rifampin; D012837:Silver Sulfadiazine
keywords: Bacteremia; Central venous catheter; Chlorhexidine; Impregnated-catheter; Silver sulfadiazine