title: Total synthesis of calothrixin B via sequential Sonogashira coupling/copper-catalyzed oxidative cyclization.
abstract: A total synthesis of the antimalarial indolo[3,2-j]phenanthridine alkaloid calothrixin B is reported. The key intermediate, ketoester 11, was assembled using sequential Sonogashira coupling and intra/intermolecular fashioned copper-catalyzed oxidative cyclization reactions.
authors.affiliation: School of Chemistry, University of Hyderabd, Hyderabad-500046, India. rnsc@uohyd.ernet.in.
authors.forename: Nagarajan
authors.initials: N
authors.lastname: Ramkumar
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Nagarajan
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D058451:Oxidative Coupling
chemical_list: D000962:Antimalarials; D026121:Indole Alkaloids; C418327:calothrixin B; D003300:Copper