title: Glucose-Lowering Efficacy of Water Extract of Malvastrum coromandelianum in Type 2 Diabetes Subjects: A Double Blind, Randomized Controlled Trial.
abstract: BACKGROUND
  Water extract from Malvastrum coromandelianum (Linn.) Garcke (MC) has been shown to have glucose lowering effect, short- and long-term safety in animal studies. A preliminary study in human reveals safety and its potential use as an adjunctive treatment to antihyperglycemic medications.
  
  
  OBJECTIVE
  To investigate the glycemic-lowering efficacy ofMC in type 2 diabetes subjects.
  
  
  METHODS
  A multicenter randomized, double-blind, placebo-controlled trial was conducted. Seventy-one diabetes subjects, who were treated with either diet control or single oral anti-diabetic drug (sulphonylurea or biguanide) with HbA1C between 6.5-9%, were recruited. Subjects were randomized to take MC tablets in a total dose of 1,200 mg/day or placebo for 12 weeks. Clinical parameters, glycemic control, HOMA-IR and HOMA-β were assessed.
  
  
  RESULTS
  Both MC (n = 34) and placebo (n = 37) groups had comparable baseline characteristics with a mean baseline HbA1C of 7.6 ± 0.82 vs. 7.5 ± 0.8%, respectively. During the study, HbA1C did not differ statistically after 4, 8 and 12 weeks of treatment (7.7 ± 0.97 vs. 7.6 ± 1.0, 7.9 ± 1.09 vs. 7.8 ± 1.03 and 7.8 ± 1.1 vs. 7.6 ± 1.1%, respectively). The body weight, insulin resistance and insulin secretion were also similar between groups (p > 0.05). No episode of hypoglycemia was reported.
  
  
  CONCLUSIONS
  MC in a dosage of 1,200 mg/day does not have glucose lowering efficacy in type 2 diabetes.
authors.forename: Thipaporn
authors.initials: T
authors.lastname: Tharavanij
authors.forename: Kammal Kumar
authors.initials: KK
authors.lastname: Pawa
authors.forename: Puritat
authors.initials: P
authors.lastname: Maungboon
authors.forename: Pitvara
authors.initials: P
authors.lastname: Panpitpat
authors.forename: Suthon
authors.initials: S
authors.lastname: Porntisan
authors.forename: Wirote
authors.initials: W
authors.lastname: Thangcharoende
authors.forename: Adis
authors.initials: A
authors.lastname: Tasanarong
authors.forename: Garnpimol C
authors.initials: GC
authors.lastname: Ritthidej
authors.forename: Sukanya
authors.initials: S
authors.lastname: Jesadanont
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000097:blood / Q000494:pharmacology*; D008297:Male; D019660:Malvaceae; D008875:Middle Aged; D010936:Plant Extracts / Q000097:blood / Q000494:pharmacology*; D016896:Treatment Outcome; D014867:Water
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014867:Water