title: Renal Function Recovery with Total Artificial Heart Support.
abstract: Heart failure patients requiring total artificial heart (TAH) support often have concomitant renal insufficiency (RI). We sought to quantify renal function recovery in patients supported with TAH at our institution. Renal function data at 30, 90, and 180 days after TAH implantation were analyzed for patients with RI, defined as hemodialysis supported or an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 m. Between January 2008 and December 2013, 20 of the 46 (43.5%) TAH recipients (age 51 ± 9 years, 85% men) had RI, mean preoperative eGFR of 48 ± 7 ml/min/1.73 m. Renal function recovery was noted at each follow-up interval: increment in eGFR (ml/min/1.73 m) at 30, 90, and 180 days was 21 ± 35 (p = 0.1), 16.5 ± 18 (p = 0.05), and 10 ± 9 (p = 0.1), respectively. Six patients (30%) required preoperative dialysis. Of these, four recovered renal function, one remained on dialysis, and one died. Six patients (30%) required new-onset dialysis. Of these, three recovered renal function and three died. Overall, 75% (15 of 20) of patients' renal function improved with TAH support. Total artificial heart support improved renal function in 75% of patients with pre-existing significant RI, including those who required preoperative dialysis.
authors.affiliation: From the *Department of Surgery, Division of Cardiothoracic Surgery, and †Department of Medicine, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Quader
authors.forename: Adam M
authors.initials: AM
authors.lastname: Goodreau
authors.forename: Keyur B
authors.initials: KB
authors.lastname: Shah
authors.forename: Gundars
authors.initials: G
authors.lastname: Katlaps
authors.forename: Richard
authors.initials: R
authors.lastname: Cooke
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Smallfield
authors.forename: Inna F
authors.initials: IF
authors.lastname: Tchoukina
authors.forename: Luke G
authors.initials: LG
authors.lastname: Wolfe
authors.forename: Vigneshwar
authors.initials: V
authors.lastname: Kasirajan
mesh_terms: D000328:Adult; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000601:surgery*; D006354:Heart, Artificial; D006801:Humans; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D051437:Renal Insufficiency / Q000209:etiology / Q000601:surgery*