title: Serum levels of the adipokines, free fatty acids, and oxidative stress markers in obese and non-obese preeclamptic patients.
abstract: OBJECTIVE
  To investigate the roles of adipokines, free fatty acid (FFA), and oxidative stress in obese and non-obese preeclamptic patients.
  
  
  METHODS
  Gestational age-matched obese preeclamptic (n=32), non-obese preeclamptic (n=32), and non-obese normotensive healthy (n=32) pregnant women were included in the study. Serum insulin, insulin resistance, leptin, nesfatin, ghrelin, chemerin, FFA levels, total antioxidant status, total oxidant status, and oxidative stress index were determined.
  
  
  RESULTS
  Leptin and nesfatin levels were significantly lower and ghrelin levels were significantly higher in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptic groups. Chemerin and FFA levels were significantly higher in obese preeclamptics as compared to non-obese preeclamptics and normotensive group. Total antioxidant status (TAS) levels were significantly higher in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptics. Total oxidative status (TOS) and oxidative stress index (OSI) levels were significantly lower in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptics.
  
  
  CONCLUSIONS
  Serum levels of adipokines, TOS, and FFAs were significantly higher in pregnants with preeclampsia as compared to non-obese normotensive controls. Chemerin and FFA levels were significantly higher in obese preeclamptics as compared to non-obese preeclamptics.
authors.forename: A
authors.initials: A
authors.lastname: Turgut
authors.forename: A
authors.initials: A
authors.lastname: Ozler
authors.forename: N Y
authors.initials: NY
authors.lastname: Goruk
authors.forename: S Y
authors.initials: SY
authors.lastname: Tunç
authors.forename: M E
authors.initials: ME
authors.lastname: Sak
authors.forename: M S
authors.initials: MS
authors.lastname: Evsen
authors.forename: O
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: T
authors.initials: T
authors.lastname: Gul
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D009765:Obesity; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D054392:Adipokines; D015415:Biomarkers; D005230:Fatty Acids, Nonesterified