title: Biotransformation of (-)-(10E,15S)-10,11-Dehydrocurvularin.
abstract: (-)-(10E,15S)-10,11-Dehydrocurvularin (1), produced from an associated-fungus of Scolopendra subspinipes mutilans on a gram scale, was microbiologically converted to curvularin (2) and 5-methoxycurvularin (3) by Antrodiella semisupina in 61% totally isolated yield. The structures of these compounds were elucidated on the basis of spectroscopic and mass spectrometric analysis. The undescribed assignments of 1H and 13C NMR spectral data for 5-methoxycurvularin (2) has now been explicitly provided. The cytotoxic activities of compounds 1-3 against four human cancer cell lines were evaluated. Dehydrocurvularin (1) showed moderate cytotoxicity against Caski and Hep-G2, and curvularin (2) was selectively cytotoxic against MDA-MB-231.
authors.forename: Zhangshuang
authors.initials: Z
authors.lastname: Deng
authors.forename: Aiping
authors.initials: A
authors.lastname: Deng
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
authors.forename: Dachun
authors.initials: D
authors.lastname: Gong
authors.forename: Kun
authors.initials: K
authors.lastname: Zou
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Guo
mesh_terms: D001711:Biotransformation; D000077743:Diterpene Alkaloids; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal; D056945:Hep G2 Cells; D006801:Humans; D020072:Polyporales / Q000378:metabolism*; D015025:Zearalenone / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D000077743:Diterpene Alkaloids; D004365:Drugs, Chinese Herbal; D015025:Zearalenone; C574917:scolopendra alkaloids; C013455:curvularin