title: [Effect of Curcumin on Cerebral Ischemia-reperfusion Injury in Rats].
abstract: OBJECTIVE
  To investigate the effect of curcumin on cerebral ischemia-reperfusion injury in rats and its mechanism.
  
  
  METHODS
  250 male SD rats were randomly divided into five groups:sham group (Sham group), ischemia-reperfusion group (I/R group), curcumin groups with dosage of 30 mg/kg (Cur30 group), 100 mg/kg (Cur100 group) and 300 mg/kg (Cur300 group). The brain tissue damage degree, leukocyte cells infiltration, levels of TNF-α and MMP-9 expressions, and blood-brain barrier permeability were detected.
  
  
  RESULTS
  At the same time point,the score of brain tissue injury,number of leukocyte, expression of MMP-9 and TNF-α, and Evans blue dye of I/R group and Curs group were higher than those of Sham group (P < 0.05). The score of brain tissue damage degree, number of leukocyte, expression of MMP-9 and TNF-α, and Evans blue dye of Cur groups were lower than those of I/R group (P < 0.05). The Cur100 group had the best effect.
  
  
  CONCLUSIONS
  Curcumin can decrease cerebral ischemia reperfusion pathological damage significantly and suppressed the expression of MMP-9 and TNF-α, and Evans blue dye, brain tissue damage, leukocyte infiltration, which may be involved in protective mechanisms of curcumin.
authors.forename: Ling-yan
authors.initials: LY
authors.lastname: Dai
authors.forename: Bi-huan
authors.initials: BH
authors.lastname: Cheng
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy*; D003474:Curcumin / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha; D020780:Matrix Metalloproteinase 9; C572337:Mmp9 protein, rat; D003474:Curcumin