title: Lack of association of the iNOS gene polymorphism with risk of cancer: a systematic review and Meta-Analysis.
abstract: In order to investigate the association between the iNOS gene polymorphisms and susceptibility to cancer, a search of English papers was done using Pubmed, the Cochrane Library, Embase, ISI Web of Science, Google (scholar) database, and all Chinese reports were conducted using CBMDisc, Chongqing VIP database, and CNKI database. A total of eight studies were included in this meta-analysis including 1,920 cases and 2,373 controls. The results indicated that the polymorphisms in iNOS gene (C150T(Ser(608) Leu) polymorphism and polymorphic (CCTTT)n repeats) had no association with cancer risk for all genetic models. This meta-analysis suggested that the polymorphisms in the iNOS gene were not associated with cancer risk.
authors.affiliation: Department of Anesthesiology, Central Hospital, Shenyang Medical College. Shenyang, 110024, China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Jiao
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital, China Medical University. Shenyang, 110001, China.
authors.forename: Jingyang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, China.
authors.forename: Desheng
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital, China Medical University. Shenyang, 110001, China.|Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
chemical_list: D052247:Nitric Oxide Synthase Type II