title: Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy.
abstract: Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia.
authors.affiliation: Division of Nano and Energy Convergence Research, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 711-873, Korea. kimhc@dgist.ac.kr ejkim@dgist.ac.kr.
authors.forename: Hyun-Chul
authors.initials: HC
authors.lastname: Kim
authors.forename: Eunjoo
authors.initials: E
authors.lastname: Kim
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Jeong
authors.forename: Tae-Lin
authors.initials: TL
authors.lastname: Ha
authors.forename: Sang-Im
authors.initials: SI
authors.lastname: Park
authors.forename: Se Guen
authors.initials: SG
authors.lastname: Lee
authors.forename: Sung Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D006979:Hyperthermia, Induced; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D008823:Micelles; D004317:Doxorubicin