title: Synthesis of Biscoumarin and Dihydropyran Derivatives and Evaluation of Their Antibacterial Activity.
abstract: In an attempt to find a new class antibacterial agents, a series of biscoumarins (1-4) and dihydropyrans (5-13) were successfully prepared. The molecular structures of four representative compounds, that is, 4, 5, 8 and 12 were confirmed by single crystal X-ray diffraction study. These synthesized compounds were screened for their antibacterial activity in vitro against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), USA 300 (Los Angeles County clone, LAC), Staphylococcus epidermidis (S. epidermidis ATCC 14990), methicillin-resistant S. epidermidis (MRSE XJ 75284) and Escherichia coli (E. coli ATCC 25922). Additionally, there are two classical intramolecular O-H···O hydrogen bonds (HBs) in biscoumarins 1-4 and the corresponding HB energies were further performed with the density functional theory (DFT) [B3LYP/6-31G*] method.
authors.affiliation: School of Chemical Engineering, Xi'an University, Xi'an 710065, China. lijing3157@aliyun.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China. lvcwei@fmmu.edu.cn.
authors.forename: Chang-Wei
authors.initials: CW
authors.lastname: Lv
authors.affiliation: School of Chemical Engineering, Xi'an University, Xi'an 710065, China. xjli@xawl.edu.cn.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Li
authors.affiliation: Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, China. qu_di1990@126.com.
authors.forename: Di
authors.initials: D
authors.lastname: Qu
authors.affiliation: Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, China. hzh_0001@163.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, China. yangziyi@fmmu.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Jia
authors.affiliation: Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, China. xxluo3@fmmu.edu.cn.
authors.forename: Xiao-Xing
authors.initials: XX
authors.lastname: Luo
authors.affiliation: Department of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China. sjwklixia@sina.com.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, China. mingkai@fmmu.edu.cn.
authors.forename: Ming-Kai
authors.initials: MK
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; D011714:Pyrans
keywords: S. aureus; S. epidermidis; biscoumarins; dihydropyran