title: Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the spiramycin producer.
abstract: Streptomyces ambofaciens ATCC23877 is a soil bacterium industrially exploited for the production of the macrolide spiramycin which is used in human medicine as an antibacterial and anti-toxoplasmosis chemical. Its genome consists of a 8.3 Mbp linear chromosome and a 89 kb circular plasmid. The complete genome sequence reported here will enable us to investigate Streptomyces genome evolution and to discover new secondary metabolites with potential applications notably in human medicine.
authors.affiliation: Université de Lorraine, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy F-54506, France; INRA, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy F-54506, France.
authors.forename: Annabelle
authors.initials: A
authors.lastname: Thibessard
authors.affiliation: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Orsay, France.
authors.forename: Drago
authors.initials: D
authors.lastname: Haas
authors.affiliation: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Orsay, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Gerbaud
authors.affiliation: Université de Lorraine, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy F-54506, France; INRA, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy F-54506, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Aigle
authors.affiliation: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Orsay, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lautru
authors.affiliation: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Orsay, France. Electronic address: jean-luc.pernodet@i2bc.paris-saclay.fr.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Pernodet
authors.affiliation: Université de Lorraine, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy F-54506, France; INRA, Dynamique des Génomes et Adaptation Microbienne, UMR 1128, Vandœuvre-lès-Nancy F-54506, France. Electronic address: pierre.leblond@univ-lorraine.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Leblond
mesh_terms: D002876:Chromosomes, Bacterial / Q000235:genetics; D019143:Evolution, Molecular; D016680:Genome, Bacterial / Q000235:genetics*; D010957:Plasmids / Q000235:genetics; D012988:Soil Microbiology; D015572:Spiramycin / Q000378:metabolism*; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism*
chemical_list: D015572:Spiramycin
keywords: Gene clusters; Genome instability; Genome sequence; Streptomyces ambofaciens