title: Photoacoustic imaging of cerebral hypoperfusion during acupuncture.
abstract: Using acupuncture to treat cerebral hypoperfusion is a hot topic. However, there is a lack of effective tools to clarify the therapeutic effect of acupuncture on cerebral hypoperfusion. Here, we show in a mouse model of cerebral hypoperfusion that photoacoustic tomography (PAT) can noninvasively image cerebral vasculature and track total hemoglobin (HbT) concentration changes in cerebral hypoperfusion with acupuncture stimulation on the YangLingQuan (GB34) point. We measured the changes of HbT concentration and found that the HbT concentration in hypoperfusion regions was clearly lower than that in the control regions when the acupuncture was absent; however, it was significantly increased when the acupuncture was implemented on the GB34 point. We also observed the increase of vessel size and the generation of new vessels in cerebral hypoperfusion during acupuncture. Laser speckle imaging (LSI) was employed to validate some of the PAT findings.
authors.affiliation: School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, 610054, China.
authors.forename: B Z
authors.initials: BZ
authors.lastname: Chen
authors.affiliation: School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, 610054, China.
authors.forename: J G
authors.initials: JG
authors.lastname: Yang
authors.affiliation: School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, 610054, China.
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.affiliation: Institute of Laboratory Animals of Sichuan Academy of Medical Sciences and Sichuan Province People's Hospital, Chengdu, 610054, China.
authors.forename: D W
authors.initials: DW
authors.lastname: Zeng
authors.affiliation: Institute of Laboratory Animals of Sichuan Academy of Medical Sciences and Sichuan Province People's Hospital, Chengdu, 610054, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Institute of Laboratory Animals of Sichuan Academy of Medical Sciences and Sichuan Province People's Hospital, Chengdu, 610054, China.
authors.forename: N
authors.initials: N
authors.lastname: Yang
authors.affiliation: School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, 610054, China ; Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
authors.forename: H B
authors.initials: HB
authors.lastname: Jiang
keywords: (170.2655) Functional monitoring and imaging; (170.5120) Photoacoustic imaging