title: Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.
abstract: Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10(-5)). For three cis-eQTL associations (P<1.4 × 10(-3), FDR<0.05) at 1p36 (CDC42), 1p34 (CDCA8) and 2q31 (HOXD9), we evaluate the functional role of each candidate by perturbing expression of each gene in HGSOC precursor cells. Overexpression of HOXD9 increases anchorage-independent growth, shortens population-doubling time and reduces contact inhibition. Chromosome conformation capture identifies an interaction between rs2857532 and the HOXD9 promoter, suggesting this SNP is a leading causal variant. Transcriptomic profiling after HOXD9 overexpression reveals enrichment of HGSOC risk variants within HOXD9 target genes (P=6 × 10(-10) for risk variants (P<10(-4)) within 10 kb of a HOXD9 target gene in ovarian cells), suggesting a broader role for this network in genetic susceptibility to HGSOC.
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Kate
authors.initials: K
authors.lastname: Lawrenson
authors.affiliation: Medical College, Xiamen University, Xiamen 361102, China.|Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
authors.forename: Qiyuan
authors.initials: Q
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authors.affiliation: Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Kar
authors.affiliation: Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
authors.forename: Ji-Heui
authors.initials: JH
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authors.affiliation: Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tyrer
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Tassja J
authors.initials: TJ
authors.lastname: Spindler
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Janet
authors.initials: J
authors.lastname: Lee
authors.affiliation: Bioinformatics Service, Norris Medical Library, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Yibu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Departments of Pathology and Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Karst
authors.affiliation: Departments of Pathology and Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.
authors.forename: Ronny
authors.initials: R
authors.lastname: Drapkin
authors.affiliation: Department for Health Evidence, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.|Comprehensive Cancer Center, The Netherlands, PO Box 19079, 3501 DB Utrecht, The Netherlands.
authors.forename: Katja K H
authors.initials: KK
authors.lastname: Aben
authors.affiliation: Department of Epidemiology, Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California 92697, USA.
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
authors.affiliation: Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., 223040 Minsk, Belarus.
authors.forename: Natalia
authors.initials: N
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authors.affiliation: Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
authors.forename: Helen
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authors.lastname: Baker
authors.affiliation: Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA.
authors.forename: Elisa V
authors.initials: EV
authors.lastname: Bandera
authors.affiliation: Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA.|Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Bean
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
authors.forename: Matthias W
authors.initials: MW
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authors.affiliation: Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Andrew
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authors.affiliation: Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
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authors.initials: M
authors.lastname: Bisogna
authors.affiliation: Department of Gynecology and Obstetrics, Haukeland University Hospital, N-5058 Bergen, Norway.|Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
authors.forename: Line
authors.initials: L
authors.lastname: Bjorge
authors.affiliation: Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany.
authors.forename: Natalia
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authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland, 20892, USA.
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authors.initials: LA
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authors.affiliation: Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3.|Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
authors.forename: Angela
authors.initials: A
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authors.affiliation: Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
authors.forename: Fiona
authors.initials: F
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authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, 00100 Helsinki, Finland.|Department of Pathology, Helsinki University Central Hospital, FI-00014 Helsinki, Finland.
authors.forename: Ralf
authors.initials: R
authors.lastname: Butzow
authors.affiliation: Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.|Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia.|Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia.
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authors.affiliation: Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
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authors.affiliation: German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
authors.forename: Jenny
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authors.affiliation: Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
authors.forename: Georgia
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authors.affiliation: Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida 33612, USA.
authors.forename: Anne
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authors.affiliation: Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida 33612, USA.
authors.forename: Zhihua
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authors.affiliation: Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA.
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authors.initials: LS
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authors.affiliation: Harvard School of Public Health, Boston, Massachusetts 02215, USA.|Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.
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authors.initials: DW
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authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
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authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Agnieszka
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authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.affiliation: Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
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authors.affiliation: Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, 45136 Essen, Germany.|Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, 65199 Wiesbaden, Germany.
authors.forename: Andreas
authors.initials: A
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authors.affiliation: Department of Gynecology, Jena University Hospital-Friedrich Schiller University, 07737 Jena, Germany.
authors.forename: Matthias
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authors.affiliation: Faculty of Medicine, University of Southampton, Southampton SO16 5YA, UK.
authors.forename: Diana
authors.initials: D
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authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.initials: DT
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authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.|Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, USA.
authors.forename: Robert P
authors.initials: RP
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authors.affiliation: German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
authors.forename: Ursula
authors.initials: U
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authors.affiliation: University Hospital Erlangen, Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany.
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authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.|Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles California 90095, USA.
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authors.initials: PA
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authors.affiliation: Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA.
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authors.initials: BL
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authors.affiliation: Shanghai Cancer Institute, Shanghai 200030, China.
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authors.initials: YT
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authors.affiliation: Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.|Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
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authors.initials: GG
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authors.affiliation: Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.|Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
authors.forename: Marc T
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authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
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authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.initials: P
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authors.affiliation: Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, 45136 Essen, Germany.|Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, 65199 Wiesbaden, Germany.
authors.forename: Philipp
authors.initials: P
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authors.affiliation: Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia.
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authors.initials: HN
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authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hein
authors.affiliation: Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, 45136 Essen, Germany.|Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, 65199 Wiesbaden, Germany.
authors.forename: Florian
authors.initials: F
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authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Michelle A T
authors.initials: MA
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authors.affiliation: Departments of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany.
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authors.affiliation: Institute of Cancer Epidemiology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.|Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, 1165 Copenhagen, Denmark.
authors.forename: Estrid
authors.initials: E
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authors.affiliation: Gyn Clinic, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Claus
authors.initials: C
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authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan.
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authors.initials: S
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authors.affiliation: Department of Statistical Science, Duke University, Durham, North Carolina 27708, USA.
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authors.initials: ES
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authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
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authors.affiliation: Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
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authors.initials: P
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authors.affiliation: Department of Gynecology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
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authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland, 20892, USA.
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authors.initials: BT
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authors.forename: Beth Y
authors.initials: BY
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authors.affiliation: Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.|Department of Gynaecology, The Juliane Marie Centre, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Susanne
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authors.affiliation: Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina 29435, USA.
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authors.affiliation: Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA.|Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.
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authors.affiliation: Radboud University Medical Mentre, Radboud Institute for Health Sciences, 6500 HB Nijmegen, The Netherlands.
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authors.affiliation: Department of Gynecology and Obstetrics, Haukeland University Hospital, N-5058 Bergen, Norway.|Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
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authors.initials: J
authors.lastname: Kupryjanczyk
authors.affiliation: Vesalius Research Center, VIB, 3000 Leuven, Belgium.|Laboratory for Translational Genetics, Department of Oncology, University of Leuven, B-3000 Leuven, Belgium.
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authors.initials: D
authors.lastname: Lambrechts
authors.affiliation: Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
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authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Alice W
authors.initials: AW
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authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
authors.forename: Shashi
authors.initials: S
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authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, 00100 Helsinki, Finland.
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authors.initials: A
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authors.affiliation: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
authors.forename: Jenny
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authors.affiliation: Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
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authors.affiliation: College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas 77004, USA.
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authors.forename: Jolanta
authors.initials: J
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authors.affiliation: Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
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authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jan
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authors.affiliation: Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, 1165 Copenhagen, Denmark.
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authors.initials: L
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authors.affiliation: Department of Gynaecology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
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authors.initials: LF
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authors.affiliation: Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, 819-0395 Fukuoka, Japan.
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authors.affiliation: Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
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authors.initials: V
authors.lastname: McGuire
authors.affiliation: Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
authors.forename: John R
authors.initials: JR
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authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, 00100 Helsinki, Finland.
authors.forename: Heli
authors.initials: H
authors.lastname: Nevanlinna
authors.affiliation: Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, University of Glasgow, Glasgow G61 1QH, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: McNeish
authors.affiliation: Department of Women's Cancer, Institute for Women's Health, University College London, London W1T 7DN, UK.
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authors.initials: U
authors.lastname: Menon
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.|Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, USA.|Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA.|Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA.
authors.forename: Francesmary
authors.initials: F
authors.lastname: Modugno
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
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authors.initials: KB
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authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10017, USA.
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authors.affiliation: Department of Pathology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Lotte
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authors.affiliation: The University of Texas School of Public Health, Houston, Texas 77030, USA.
authors.forename: Roberta B
authors.initials: RB
authors.lastname: Ness
authors.affiliation: Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Mat Adenan Noor
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authors.affiliation: Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
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authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10017, USA.
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authors.initials: SH
authors.lastname: Olson
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10017, USA.
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authors.initials: I
authors.lastname: Orlow
authors.affiliation: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Orsulic
authors.affiliation: Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Rachel Palmieri
authors.initials: RP
authors.lastname: Weber
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Celeste L
authors.initials: CL
authors.lastname: Pearce
authors.affiliation: Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA.|Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.
authors.forename: Tanja
authors.initials: T
authors.lastname: Pejovic
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, 00100 Helsinki, Finland.
authors.forename: Liisa M
authors.initials: LM
authors.lastname: Pelttari
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Permuth-Wey
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Phelan
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.|Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: Malcolm C
authors.initials: MC
authors.lastname: Pike
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02215, USA.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Poole
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Ramus
authors.affiliation: Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut 06510, USA.
authors.forename: Harvey A
authors.initials: HA
authors.lastname: Risch
authors.affiliation: Department of Gynecologic-Oncology, Princess Margaret Hospital, and Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 2J7.
authors.forename: Barry
authors.initials: B
authors.lastname: Rosen
authors.affiliation: Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.|Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Rossing
authors.affiliation: Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Rothstein
authors.affiliation: German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Rudolph
authors.affiliation: Department of Gynecology, Jena University Hospital-Friedrich Schiller University, 07737 Jena, Germany.
authors.forename: Ingo B
authors.initials: IB
authors.lastname: Runnebaum
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Iwona K
authors.initials: IK
authors.lastname: Rzepecka
authors.affiliation: Department of Gynecology and Obstetrics, Haukeland University Hospital, N-5058 Bergen, Norway.|Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
authors.forename: Helga B
authors.initials: HB
authors.lastname: Salvesen
authors.affiliation: Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina 27710, USA.|Institut für Humangenetik Wiesbaden, 65187 Wiesbaden, Germany.
authors.forename: Joellen M
authors.initials: JM
authors.lastname: Schildkraut
authors.affiliation: Institut für Humangenetik Wiesbaden, 65187 Wiesbaden, Germany.
authors.forename: Ira
authors.initials: I
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authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
authors.forename: Thomas A
authors.initials: TA
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authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
authors.forename: Xiao-Ou
authors.initials: XO
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authors.affiliation: Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, 96813, USA.
authors.forename: Yurii B
authors.initials: YB
authors.lastname: Shvetsov
authors.affiliation: Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK.
authors.forename: Nadeem
authors.initials: N
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authors.affiliation: Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
authors.forename: Weiva
authors.initials: W
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authors.affiliation: Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
authors.forename: Honglin
authors.initials: H
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authors.affiliation: Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Melissa C
authors.initials: MC
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authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
authors.forename: Lara
authors.initials: L
authors.lastname: Sucheston
authors.affiliation: Department of Gynecology and Obstetrics, Haukeland University Hospital, N-5058 Bergen, Norway.|Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
authors.forename: Ingvild L
authors.initials: IL
authors.lastname: Tangen
authors.affiliation: Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia.|University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Soo-Hwang
authors.initials: SH
authors.lastname: Teo
authors.affiliation: Harvard School of Public Health, Boston, Massachusetts 02215, USA.|Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Terry
authors.affiliation: Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.|Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
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authors.initials: PJ
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authors.affiliation: Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
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authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
authors.forename: Ya-Yu
authors.initials: YY
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authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02215, USA.
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authors.initials: SS
authors.lastname: Tworoger
authors.affiliation: Department of Gynaecology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
authors.forename: Anne M
authors.initials: AM
authors.lastname: van Altena
authors.affiliation: Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
authors.forename: Els
authors.initials: E
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authors.affiliation: Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
authors.forename: Ignace
authors.initials: I
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authors.affiliation: Department of Health Science Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
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authors.initials: RA
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authors.affiliation: Department of Obstetrics and Gynecology, University of Ulm, 89075 Ulm, Germany.
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authors.initials: S
authors.lastname: Wang-Gohrke
authors.affiliation: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
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authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland, 20892, USA.
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authors.initials: N
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authors.affiliation: Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
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authors.initials: AS
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authors.affiliation: Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
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authors.initials: KG
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authors.affiliation: Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, 96813, USA.
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authors.initials: LR
authors.lastname: Wilkens
authors.affiliation: Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, 50603 Kuala Lumpur, Malaysia.|University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, 50603 Kuala Lumpur, Malaysia.
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authors.initials: YL
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authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Xifeng
authors.initials: X
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authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Anna H
authors.initials: AH
authors.lastname: Wu
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland, 20892, USA.
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authors.initials: H
authors.lastname: Yang
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Epidemiology, Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California 92697, USA.
authors.forename: Argyrios
authors.initials: A
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authors.affiliation: Cancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center &Research Institute, Tampa, Florida 33612, USA.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Monteiro
authors.affiliation: Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Pharoah
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Simon A
authors.initials: SA
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authors.affiliation: Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Freedman
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D045744:Cell Line, Tumor; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000378:metabolism; D053589:Nuchal Cord; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism; D011485:Protein Binding; D040641:Quantitative Trait Loci
chemical_list: C088822:HOXD9 protein, human; D018398:Homeodomain Proteins; D009363:Neoplasm Proteins