title: Association Between Body Composition and Bone Mineral Density in Men on Hemodialysis.
abstract: Studies have revealed complex interactions between bone and fat, however there are few studies about this crosstalk in patients with chronic kidney disease. This study investigated possible relationship between bone mineral density (BMD) and body composition in patients who underwent hemodialysis. Twenty patients were enrolled in a cross-sectional study (47.0 [42.3-56.8] years, body mass index 26.0 ± 4.2 kg/m, dialysis vintage of 48.5 [26.7-95.7] months). Body composition and BMD were assessed by dual-energy X-ray absorptiometry. Leptin and parathormone levels were analyzed using Multiplex kits (R&D System Inc). Low bone mass in the femoral neck was reported in 54.8% of patients. Total BMD and total T-score were positively correlated with lean mass (r = 0.46, P = 0.04; r = 0.47, P = 0.04, respectively), but not with leptin or body fat mass. In conclusion, lean body mass is probably important to maintain bone health in male patients who underwent hemodialysis.
authors.affiliation: Graduate Program in Medical Sciences (SMSdAM), Fluminense Federal University, Rio de Janerio, Brazil; Fluminense Federal University Nutritional and Functional Assessment Laboratory (VW), Fluminense Federal University, Rio de Janerio, Brazil; and Graduate Program in Cardiovascular Sciences (DM), Fluminense Federal University, Rio de Janerio, Brazil.
authors.forename: Sandra M S de A
authors.initials: SM
authors.lastname: Marinho
authors.forename: Vivian
authors.initials: V
authors.lastname: Wahrlich
authors.forename: Denise
authors.initials: D
authors.lastname: Mafra
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D015519:Bone Density; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D006435:Renal Dialysis / Q000379:methods*; D051437:Renal Insufficiency / Q000503:physiopathology* / Q000628:therapy