title: Humoral Immunity to Cytomegalovirus Glycoprotein B in Patients With Breast Cancer and Matched Controls: Contribution of Immunoglobulin γ, κ, and Fcγ Receptor Genes.
abstract: Increasing evidence implicates human cytomegalovirus (HCMV) in the etiopathogenesis of breast cancer. Antibodies to this virus in patients with breast cancer have been reported, but no large-scale studies have been conducted to determine whether the antibody levels differ between patients and matched controls. Using specimens from a large (1712 subjects) multiethnic case-control study, we aimed to determine whether the levels of antibodies to the HCMV glycoprotein B (gB) differed between patients and controls and whether they were associated with particular immunoglobulin γ marker (GM), κ marker (KM), and Fcγ receptor (FcγR) genotypes. A combined analysis showed that anti-gB immunoglobulin G antibody levels were higher in healthy controls than in patients (P < .0001). Stratified analyses showed population-specific differences in the magnitude of anti-gB antibody responsiveness and in the contribution of particular GM, KM, and FcγR genotypes to these responses. These findings may have implications for HCMV-based immunotherapy against breast cancer and other HCMV-associated diseases.
authors.affiliation: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston.
authors.forename: Janardan P
authors.initials: JP
authors.lastname: Pandey
authors.affiliation: Department of Biostatistics, Virginia Commonwealth University, Richmond.
authors.forename: Guimin
authors.initials: G
authors.lastname: Gao
authors.affiliation: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston.
authors.forename: Aryan M
authors.initials: AM
authors.lastname: Namboodiri
authors.affiliation: Division of Epidemiology, National Cancer Center, Tokyo.
authors.forename: Motoki
authors.initials: M
authors.lastname: Iwasaki
authors.affiliation: Department of Surgery, Nagano Matsushiro General Hospital, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kasuga
authors.affiliation: Nikkei Disease Prevention Center, São Paulo, Brazil.
authors.forename: Gerson S
authors.initials: GS
authors.lastname: Hamada
authors.affiliation: Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D001943:Breast Neoplasms / Q000150:complications*; D016022:Case-Control Studies; D003586:Cytomegalovirus Infections / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins; D017452:Receptors, IgG; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus
keywords: FcγR genes; GM/KM allotypes; glycoprotein B; human cytomegalovirus; humoral immunity