title: Risk-adapted strategies for the treatment of Hodgkin lymphoma.
abstract: BACKGROUND
  Over the past several decades, Hodgkin lymphoma (HL) has become a highly treatable lymphoid malignancy with excellent response rates and long-term disease-free survival. Late-toxicities, however, continue to be an area of significant concern. Recent studies have evaluated novel approaches to limit long-term toxicity without adversely impacting short-term survival. While early or interim PET scan has been correlated with PFS and OS in HL, the modification of therapy based on interim PET (response-adapted therapy) has been evaluated in retrospective and prospective cohorts. This paper will review evidence for the role of response-adapted therapy in HL.
  
  
  METHODS
  Data from completed and ongoing retrospective and prospective cohorts of HL patients were reviewed utilizing pubmed and clinicaltrials.org and pertinent studies culled to compile this review article.
  
  
  CONCLUSIONS
  While response-adapted therapy represents a promising area of research which may ultimately become standard-of-care, current data does not unequivocally endorse this approach, which should be used with caution outside of a clinical trial.
authors.affiliation: a 1 Washington University, Division of Oncology, Department of Medicine , St Louis, MO 63110, USA.|b 2 Washington University School of Medicine, Division of Oncology, Department of Internal Medicine , 660 S. Euclid Avenue, Campus Box 8056, St. Louis, MO 63110, USA +1 31 43 62 56 54 ; +1 31 44 54 79 41 ; KCARSON@DOM.wustl.edu.
authors.forename: Jesse
authors.initials: J
authors.lastname: Keller
authors.affiliation: a 1 Washington University, Division of Oncology, Department of Medicine , St Louis, MO 63110, USA.|b 2 Washington University School of Medicine, Division of Oncology, Department of Internal Medicine , 660 S. Euclid Avenue, Campus Box 8056, St. Louis, MO 63110, USA +1 31 43 62 56 54 ; +1 31 44 54 79 41 ; KCARSON@DOM.wustl.edu.|c 3 Research Service, St. Louis Veterans Affairs Medical Center , 501 N. Grand Blvd Suite 300, St. Louis, MO 63103, USA.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Carson
mesh_terms: D018572:Disease-Free Survival; D006689:Hodgkin Disease / Q000473:pathology / Q000628:therapy*; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
keywords: Hodgkin lymphoma; interim PET; risk stratification