title: Resveratrol caused apoptosis in QGY-7701 cells.
abstract: OBJECTIVE
  This study aims to evaluate the cytotoxicity of resveratrol in QGY-7701 cells using a cell viability assay and determine genetic damages after 24-h exposure to concentrations of 6, 12, and 24 µmol · L-1.
  
  
  METHODS
  Cell viability and genetic damages were determined using a WST-1 assay and Hoechst 33342 staining with single cell gel electrophoresis (SCGE), respectively. Reactive oxygen species (ROS) levels were also determined.
  
  
  RESULTS
  The results demonstrated that resveratrol inhibited QGY-7701 cell growth and decreased their viability in a dose-dependent manner. Furthermore, resveratrol caused nuclear morphological changes and DNA damage, promoted ROS levels, and induced cell apoptosis.
  
  
  CONCLUSIONS
  These results suggest that resveratrol may induce QGY-7701 cell apoptosis by triggering excessive ROS generation and DNA damage.
authors.affiliation: Department of Oncology, People's Hospital of Xintai City, Affiliated to Taishan Medical University, Xintai, Shandong Province, P. R. China. shdljp@126.com.
authors.forename: J-P
authors.initials: JP
authors.lastname: Li
mesh_terms: D017209:Apoptosis; D004249:DNA Damage / Q000235:genetics*; D006801:Humans; D017382:Reactive Oxygen Species; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D017382:Reactive Oxygen Species; D013267:Stilbenes; D000077185:Resveratrol