title: Gastrointestinal stromal tumour metastatic to the epididymis.
abstract: Gastrointestinal stromal tumours (GIST) are mesenchymal neoplasms with a propensity to metastasise to the liver and peritoneal cavity. Since the advent of tyrosine kinase inhibitors, outcomes for patients with metastatic GIST have improved dramatically. Secondary to the longevity in survival, patients may develop metastatic disease in very unusual locations, which poses significant diagnostic dilemmas and management challenges. We report a case of a patient with GIST who presented with an epididymal metastasis manifesting as a scrotal mass. Resistance to targeted medical therapies continues to pose a challenge, and our case highlights the importance of a multidisciplinary approach in such patients, including long-term follow-up.
authors.affiliation: Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahmad
authors.affiliation: Department of Pathology, Roger Williams Medical Center, Providence, Rhode Island, USA.
authors.forename: Norman Peter
authors.initials: NP
authors.lastname: Libbey
authors.affiliation: Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island, USA.
authors.forename: Ponnandai
authors.initials: P
authors.lastname: Somasundar
authors.affiliation: Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island, USA.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Katz
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D004822:Epididymis / Q000648:ultrastructure*; D005770:Gastrointestinal Neoplasms / Q000473:pathology* / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology* / Q000601:surgery; D005834:Genital Neoplasms, Male / Q000556:secondary* / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010671:Phenylurea Compounds / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D012611:Scrotum / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D011725:Pyridines; C559147:regorafenib; D000068877:Imatinib Mesylate