title: Successful Scene Encoding in Presymptomatic Early-Onset Alzheimer's Disease.
abstract: BACKGROUND
  Brain regions critical to episodic memory are altered during the preclinical stages of Alzheimer's disease (AD). However, reliable means of identifying cognitively-normal individuals at higher risk to develop AD have not been established.
  
  
  OBJECTIVE
  To examine whether functional MRI can detect early functional changes associated with scene encoding in a group of presymptomatic presenilin-1 (PSEN1) E280A mutation carriers.
  
  
  METHODS
  Participants were 39 young, cognitively-normal individuals from an autosomal dominant early-onset AD kindred, located in Antioquia, Colombia. Participants performed a functional MRI scene encoding task and a post-scan subsequent memory test.
  
  
  RESULTS
  PSEN1 mutation carriers exhibited hyperactivation within medial temporal lobe regions (hippocampus,parahippocampal formation) during successful scene encoding compared to age-matched non-carriers.
  
  
  CONCLUSIONS
  Hyperactivation in medial temporal lobe regions during scene encoding is seen in individuals genetically-determined to develop AD years before their clinical onset. Our findings will guide future research with the ultimate goal of using functional neuroimaging in the early detection of preclinical AD.
authors.affiliation: Grupo de Neurociencias, Universidad de Antioquia, Medellín, Colombia.|Departments of Psychiatry and Neurology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Yakeel T
authors.initials: YT
authors.lastname: Quiroz
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Kim Celone
authors.initials: KC
authors.lastname: Willment
authors.affiliation: Instituto de Alta Tecnología Médica - IATM, Medellín, Colombia.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Castrillon
authors.affiliation: Center for Memory and Brain, Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
authors.forename: Martha
authors.initials: M
authors.lastname: Muniz
authors.affiliation: Grupo de Neurociencias, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Francisco
authors.initials: F
authors.lastname: Lopera
authors.affiliation: VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Budson
authors.affiliation: Center for Memory and Brain, Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.|Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
authors.forename: Chantal E
authors.initials: CE
authors.lastname: Stern
mesh_terms: D000328:Adult; D017668:Age of Onset; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology* / Q000523:psychology; D058070:Asymptomatic Diseases; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004252:DNA Mutational Analysis; D005260:Female; D006579:Heterozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009154:Mutation; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D053764:Presenilin-1 / Q000235:genetics*; D014796:Visual Perception / Q000502:physiology*
chemical_list: C508853:PSEN1 protein, human; D053764:Presenilin-1
keywords: Alzheimer’s disease; autosomal-dominant; functional MRI; memory encoding; presenilin-1