title: Convenient synthesis of α,β-unsaturated γ-butyrolactones and γ-butyrolactams via decarboxylative iodination of paraconic acids and β-carboxyl-γ-butyrolactams using 1,3-diiodo-5,5-dimethylhydantoin.
abstract: A convenient synthetic approach to α,β-unsaturated γ-butyrolactones and α,β-unsaturated γ-butyrolactams is developed. The reaction proceeds via decarboxylative iodination of paraconic acids and β-carboxyl-γ-butyrolactams, employing 1,3-diiodo-5,5-dimethylhydantoin (DIH) under irradiation, followed by dehydroiodination of β-iodo-γ-butyrolactones and γ-butyrolactams providing good yields of α,β-unsaturated γ-butyrolactones and γ-butyrolactams, which are synthetically useful building blocks in organic synthesis.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. darunee.soo@mahidol.ac.th.
authors.forename: Supasorn
authors.initials: S
authors.lastname: Phae-Nok
authors.forename: Chutima
authors.initials: C
authors.lastname: Kuhakarn
authors.forename: Manat
authors.initials: M
authors.lastname: Pohmakotr
authors.forename: Vichai
authors.initials: V
authors.lastname: Reutrakul
authors.forename: Darunee
authors.initials: D
authors.lastname: Soorukram