title: Highly Selective Synthesis of Halomon, Plocamenone, and Isoplocamenone.
abstract: Over 160 chiral vicinal bromochlorinated natural products have been identified; however, a lack of synthetic methods for the selective incorporation of halogens into organic molecules has hindered their synthesis. Here we disclose the first total synthesis and structural confirmation of isoplocamenone and plocamenone, as well as the first selective and scalable synthesis of the preclinical anticancer natural product halomon. The synthesis of these inter-halogenated compounds has been enabled by our recently developed chemo-, regio-, and enantioselective dihalogenation reaction.
authors.affiliation: Department of Chemistry, Stanford University , Stanford, California 94305, United States.
authors.forename: Cyril
authors.initials: C
authors.lastname: Bucher
authors.affiliation: Department of Chemistry, Stanford University , Stanford, California 94305, United States.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Deans
authors.affiliation: Department of Chemistry, Stanford University , Stanford, California 94305, United States.
authors.forename: Noah Z
authors.initials: NZ
authors.lastname: Burns
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis*; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis*
chemical_list: D001688:Biological Products; D006846:Hydrocarbons, Halogenated; C076123:6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene