title: Acute and long-term effects of hyperbaric oxygen therapy on hemorheological parameters in patients with various disorders.
abstract: Inhalation of 100% oxygen in a hyperbaric chamber has been accepted as a useful treatment for patients with various pathologies who suffer from hypoxia. The oxidative effects of hyperbaric oxygen (HBO) on RBCs have been investigated in animals but there is not enough data on hemorheological parameters in patients following HBO treatment (HBOT).In this study, we investigated the effect of HBO on hemorheological and haematological parameters during treatment. Red blood cell (RBC) deformability and aggregation, blood and plasma viscosity and superoxide dismutase activity were investigated in patients who underwent HBOT. Hematological parameters were determined by an electronic hematology analyzer. A Laser-assisted Optical Rotational Cell Analyzer (LORCA) was used to measure RBC deformability. RBC aggregation was measured for cells in autologous plasma and for cells resuspended in PBS containing Dextran70 (3% ) by using a Myrenne Aggregometer. A Wells-Brookfield cone/plate rotational viscometer was used for viscosity measurements. According to our results, a significant decrement of the hematocrit and the RBC count was observed after the 20th session of HBOT compared to the baseline, but none of the hemorheological parameters changed significantly. Our results showed that HBOT did not cause any significant changes in hemorheological parameters, thereby not representing any problems for the patients.
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Capa, Istanbul, Turkey.
authors.forename: Mukaddes
authors.initials: M
authors.lastname: Sinan
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Capa, Istanbul, Turkey.
authors.forename: Nesrin Zeynep
authors.initials: NZ
authors.lastname: Ertan
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Underwater and Hyperbaric Medicine, Capa, Istanbul, Turkey.
authors.forename: Bengusu
authors.initials: B
authors.lastname: Mirasoglu
authors.affiliation: Koc University, Faculty of Medicine, Department of Physiology, Sariyer, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yalcin
authors.affiliation: Koc University, Faculty of Medicine, Department of Physiology, Sariyer, Istanbul, Turkey.
authors.forename: Nazlı
authors.initials: N
authors.lastname: Atac
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Underwater and Hyperbaric Medicine, Capa, Istanbul, Turkey.
authors.forename: Akin Savas
authors.initials: AS
authors.lastname: Toklu
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Biochemistry, Capa, Istanbul, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Basaran-Kucukgergin
authors.affiliation: Koc University, Faculty of Medicine, Department of Physiology, Sariyer, Istanbul, Turkey.
authors.forename: Oguz Kerim
authors.initials: OK
authors.lastname: Baskurt
mesh_terms: D015687:Cell Hypoxia / Q000276:immunology*; D005260:Female; D018056:Hemorheology / Q000276:immunology*; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D008875:Middle Aged
keywords: HBOT; RBC aggregation; SOD; deformability; viscosity