title: From Sex Determination to Initial Folliculogenesis in Mammalian Ovaries: Morphogenetic Waves along the Anteroposterior and Dorsoventral Axes.
abstract: Gonadal sex in most mammals is determined based on sex differentiation of the supporting cell lineages. In mouse XY gonads, SRY induces SOX9 upregulation and subsequent FGF9 expression by embryonic day 11.5 (E11.5), leading to the differentiation of Sertoli cells. XX gonads, lacking SRY action, start on the ovarian program through the actions of WNT4 and FOXL2 from around E11.5-12.0. These 2 ovarian factors, together with retinoic acid (RA) action, promote feminization partially through the repression of the masculinizing activities of SOX9, FGF9 and DMRT1. RA initiates meiosis in female germ cell cysts, in which intercellular bridges between interconnected germ cells rapidly undergo cyst breakdown by E17.5. Ovarian morphogenesis is characterized by continuous recruitment of pre-granulosa progenitor cells from the coelomic epithelia during the embryonic stage, which results in the formation of ovigerous cords and tight packing of non-interconnected oocytes (i.e. oocyte nests) at the perinatal stages. At birth, the oocyte nests break down into single oocytes surrounded by granulosa cells, leading to the assembly of primordial follicles. This review focuses on recent advances in the molecular and cellular events of initial ovarian differentiation, meiotic initiation, germ cell nest breakdown, and primordial follicle formation based on anatomical and morphogenetic aspects.
authors.affiliation: Department of Experimental Animal Model for Human Disease, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Masami
authors.initials: M
authors.lastname: Kanai-Azuma
authors.forename: Yoshiakira
authors.initials: Y
authors.lastname: Kanai
mesh_terms: D000818:Animals; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics; D005865:Gestational Age; D008322:Mammals / Q000196:embryology*; D008540:Meiosis; D051379:Mice; D009024:Morphogenesis / Q000235:genetics; D006080:Ovarian Follicle / Q000196:embryology* / Q000254:growth & development; D010053:Ovary / Q000196:embryology*; D055758:SOX9 Transcription Factor / Q000502:physiology; D019849:Sex Determination Processes / Q000235:genetics / Q000502:physiology*; D012733:Sex Differentiation / Q000235:genetics / Q000502:physiology; D051876:Sex-Determining Region Y Protein; D014212:Tretinoin / Q000502:physiology; D060449:Wnt Signaling Pathway / Q000502:physiology; D051176:beta Catenin / Q000502:physiology
chemical_list: D051858:Forkhead Transcription Factors; D055758:SOX9 Transcription Factor; D051876:Sex-Determining Region Y Protein; D051176:beta Catenin; D014212:Tretinoin