title: Effect of single nucleotide polymorphisms in the ATP-binding cassette B1 gene on the clinical outcome of traumatic brain injury.
abstract: The critical role of ATP-binding cassette B1 (ABCB1) in the function of the blood-brain barrier led us to conducted this prospective study in order to investigate the clinical outcome of patients suffering from severe traumatic brain injury. A total of 182 patients with traumatic brain injury were included in our study. Genotyping of ABCB1 C3435T and G2677T/A was conducted using polymerase chain reaction-restriction fragment length polymorphism. Using multivariate-logistic regression analysis, we found that patients carrying the CT+CC genotype of ABCB1 C3435T were more likely to have a better neurological outcome when compared with the TT genotype (odds ratio = 2.71, 95% confidence interval = 1.12-6.86). However, no significant association was found between the G2677T/A polymorphism and outcome of traumatic brain injury patients. Our study provides important information regarding the prognostic value of ABCB1 C3435T, and the ABCB1 C3435T polymorphism may be used as a predictive marker for the outcome of traumatic brain injury patients.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: D S
authors.initials: DS
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: H
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: D
authors.initials: D
authors.lastname: Geng
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000097:blood / Q000235:genetics; D000328:Adult; D000483:Alleles; D001812:Blood-Brain Barrier / Q000378:metabolism; D001930:Brain Injuries / Q000097:blood / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011446:Prospective Studies
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B