title: Association between NF-κBI and NF-κBIA polymorphisms and coronary artery disease.
abstract: Coronary artery disease (CAD) is the leading cause of fatalities worldwide. Nuclear factor (NF)-κB is a transcription factor that controls cell proliferation, differentiation and immunity. To the best of our knowledge, the present study is the first investigation of the association between CAD andNF-κB1-94 W/D/NF-κBIA3'-untranslated region (3'-UTR) A→G polymorphisms. The study population comprised 226 CAD patients and 201 controls. There was no significant difference inNF-κB1A3'-UTR A→G in the allele and genotype frequencies between case and control populations. The D allele frequency ofNF-κB1-94 in the case group was significantly higher compared to the control group (P=0.028, odds ratio=1.37). The genotype frequency ofNF-κB1-94 DD in the case group was significantly higher compared to the controls (P=0.028). Linkage analysis showed a close linkage among these 2 genes (P<0.001 for case and control), and AD and GD haplotypes were associated with CAD (P<0.001; P=0.015, respectively).NF-κB1-94 DD genotype can be a significant risk factor for the development of CAD.
authors.affiliation: Department of Medical Biology, Cumhuriyet University, 58140 Sivas, Turkey.
authors.forename: Serdal
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey.
authors.forename: Özge
authors.initials: Ö
authors.lastname: Korkmaz
authors.affiliation: Department of Molecular Biology and Genetics, Faculty of Science, Cumhuriyet University, 58140 Sivas, Turkey.
authors.forename: Nil
authors.initials: N
authors.lastname: Özbilüm
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey.
authors.forename: Öcal
authors.initials: Ö
authors.lastname: Berkan
keywords: coronary artery disease; genetic polymorphism; nuclear factor-κB1; nuclear factor-κBIA