title: The Efficacy of One Molar Contrast Material in the Evaluation of Breast Lesions with MR Imaging.
abstract: BACKGROUND
  To investigate the efficacy of 1 molar (containing 1 mol/mL gadobutrol) contrast material in the differentiation of malignant and benign breast lesions with MRI.
  
  
  METHODS
  Thirty-seven women (age range: 22-77 years, mean: 43.7 years) with 76 breast lesions were included in this study. Dynamic post-contrast images with 0.2 mL/kg gadobutrol (Gadovist) injection were obtained in all patients. Contrast-to-noise-ratio (CNR) of the lesions, as well as their contrast enhancement patterns (ring, heterogeneous, homogenous), and perilesional increased vascularity were studied.
  
  
  RESULTS
  Fifty-six benign and 20 malignant lesions were examined histopathologically. In malignant cases, heterogeneous and peripheral enhancements were most commonly determined, whereas homogeneous enhancement was most commonly determined in benign cases. CNR was 450% in malignant lesions, and 60% in benign lesions.
  
  
  CONCLUSIONS
  Type II/III contrast-time curves, ring/heterogeneous enhancement, prominent increase in CNR, and perilesional vascularity increase are important findings determining malignancy, whereas Type I curves, homogenous enhancement, a slight increase in CNR, and absence of perilesional vascularity increase support findings of benign breast lesions. By increasing CNR and providing increased perilesional vascularity, Gadovist can help in the determination of malignant breast lesions.
authors.affiliation: Department of Radiology, Yüzüncü Yıl University Medical Faculty, Van, Turkey.
authors.forename: Nursen
authors.initials: N
authors.lastname: Toprak
authors.affiliation: Department of Radiology, Yüzüncü Yıl University Medical Faculty, Van, Turkey.
authors.forename: Ozkan
authors.initials: O
authors.lastname: Unal
authors.affiliation: Department of Radiology, Gazi University Medical Faculty, Ankara, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Avcu
keywords: Breast; Gadolinium DTPA; Magnetic Resonance Imaging