title: Predictors and Timing of ATT Initiation among HIV-TB Patients at ART Centers of Karnataka, India: Two Year Follow-Up.
abstract: BACKGROUND
  In India, TB and HIV co-infection remains as a serious public health problem. From 2006 onwards, the intensified TB-HIV collaborative activities are being jointly implemented by National AIDS Control Programme (NACP) and Revised National TB Control programme (RNTCP) at high HIV burden states.
  
  
  OBJECTIVE
  To determine (a) the predictors of outcome among a cohort of HIV-TB co-infected patients after two years after initiation of ART treatment. (b) prognostic significance of time difference between the initiation of ATT and ART in HIV-TB co-infected patients.
  
  
  METHODS
  Patients registered at sixteen ART centres in Karnataka, from October through December 2009 formed the study cohort and were followed till December 2011.
  
  
  RESULTS
  A total of 604 HIV-TB patients were registered. Follow-up (a) at the end of one year had shown 63.6% (377)patients with unfavorable TB treatment outcomes (b) at the end of second year, 55.6% (336)patients were alive on ART treatment. The variables male, smear negative TB, CD4 count less than 50cells per cumm and unfavorable TB outcome were significantly associated with unfavorable ART treatment outcome.
  
  
  CONCLUSIONS
  The programmes need to review the existing strategies and strengthen HIV-TB collaborative activities for timely treatment initiation with intensive monitoring of HIV-TB patients on treatment.
authors.affiliation: State TB office, Bangalore, Karnataka, India.
authors.forename: Suresh
authors.initials: S
authors.lastname: Shastri
authors.affiliation: ESIC Medical College and PGIMSR, Bangalore, Karnataka, India.
authors.forename: Sharath Burugina
authors.initials: SB
authors.lastname: Nagaraja
authors.affiliation: International Union Against Tuberculosis and Lung Disease (The Union), South East Asia Office Regional Office, New Delhi, India.
authors.forename: Jaya Prasad
authors.initials: JP
authors.lastname: Tripathy
authors.affiliation: International Union Against Tuberculosis and Lung Disease (The Union), South East Asia Office Regional Office, New Delhi, India.
authors.forename: Srinath
authors.initials: S
authors.lastname: Satyanarayana
authors.affiliation: National AIDS Control Organization, New Delhi, India.
authors.forename: Bharat Bhushan
authors.initials: BB
authors.lastname: Rewari
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000188:drug therapy / Q000382:microbiology / Q000821:virology; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007194:India; D007223:Infant; D007231:Infant, Newborn; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D011379:Prognosis; D016016:Proportional Hazards Models; D013997:Time Factors; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D000998:Antiviral Agents