title: Non-functional parathyroid carcinoma: a case report and review of the literature.
abstract: Non-functional parathyroid carcinoma is an exceedingly rare disease with 31 reported cases since 1909. Because of the scarce number of cases of non-functional parathyroid carcinoma, there are no evidence-based recommendations for its optimal treatment. Surgery, including en bloc resection of the carcinoma, ipsilateral thyroid lobe and isthmus together with a neck dissection only in case of lymph node involvement, is the main treatment for non-functioning parathyroid carcinoma. The patient usually has a poorer prognosis because of detection at advanced stages, the relative ineffectiveness of adjuvant treatment modalities and the lack of adequate parameters for clinical follow-up. In this report, we present a case of non-functional parathyroid carcinoma at our institution, and we review the previous literature to discuss the latest advances in the diagnosis and treatment of this rare disease.
authors.affiliation: a Department of Head and Neck Surgery ; Shandong Cancer Hospital & Institute ; Jinan , China.|b Department of Medicine and Life Sciences College of Shandong Academy of Medical Sciences ; Jinan University ; Jinan , China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: c Department of Radiation Oncology ; Shandong Cancer Hospital & Institute ; Jinan , China.
authors.forename: Dali
authors.initials: D
authors.lastname: Han
authors.affiliation: a Department of Head and Neck Surgery ; Shandong Cancer Hospital & Institute ; Jinan , China.
authors.forename: Wanjun
authors.initials: W
authors.lastname: Chen
authors.affiliation: a Department of Head and Neck Surgery ; Shandong Cancer Hospital & Institute ; Jinan , China.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: a Department of Head and Neck Surgery ; Shandong Cancer Hospital & Institute ; Jinan , China.
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a Department of Head and Neck Surgery ; Shandong Cancer Hospital & Institute ; Jinan , China.
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.affiliation: d Department of Pathology ; Shandong Cancer Hospital & Institute ; Jinan , China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Gao
authors.affiliation: a Department of Head and Neck Surgery ; Shandong Cancer Hospital & Institute ; Jinan , China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Zou
authors.affiliation: a Department of Head and Neck Surgery ; Shandong Cancer Hospital & Institute ; Jinan , China.
authors.forename: Aiju
authors.initials: A
authors.lastname: Yang
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000601:surgery; D010280:Parathyroid Glands / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D014463:Ultrasonography
keywords: carcinoma; non-functional; parathyroid; surgery