title: Neurological deterioration in cauda equina syndrome is probably progressive and continuous. Implications for clinical management.
abstract: Fifty-six human and animal studies of cauda equina syndrome (CES) were reviewed. The evidence from human studies was poor (level IV). Evidence from animal studies and limited evidence from human studies suggest that structural and functional neurological losses are a progressive, continuous process. The longer the cauda equina nerve roots are compressed the greater the harm and the poorer the extent of recovery. This should prompt diagnosis and surgery for all CES patients as soon as practicably possible.
authors.affiliation: a Newcastle Nuffield Hospital , Newcastle upon Tyne , UK.
authors.forename: Nicholas V
authors.initials: NV
authors.lastname: Todd
mesh_terms: D000818:Animals; D019317:Evidence-Based Medicine; D006801:Humans; D019636:Neurodegenerative Diseases / Q000473:pathology* / Q000628:therapy*; D011128:Polyradiculopathy / Q000473:pathology* / Q000628:therapy*; D020127:Recovery of Function
keywords: cauda equina syndrome; continuum of injury; evidence-based medicine; surgical treatment; thresholds of injury