title: Serum levels of phytoestrogens as biomarkers of intake in Mexican women.
abstract: Phytoestrogens have generated interest in human health in view of their potential effect to reduce the risk of developing chronic diseases. Serum levels of phytoestrogens have been proposed as an alternative to measure the exposure of phytoestrogens. We evaluated the use of serum as a biomarker of phytoestrogen's intake in healthy women. Phytoestrogens in serum (luteolin, kaempferol, equol, biochanin A, formononetin, quercetin, naringenin, coumestrol, secoisolariciresinol, genistein, matairesinol, enterolactone, enterodiol, daidzein, glycitein and resveratrol) were analyzed by HPLC-ESI-MS. Subjects were asked to recall all foods and beverages consumed the previous 24 h. Association of dietary intake and serum concentrations was performed by Spearman correlation. Correlations were found for naringenin (r = 0.47, p < 0.001), luteolin (r = 0.4 p < 0.001), genistein (r = 0.32, p < 0.01) enterolactone (r = 0.35, p = 0.0553), coumestrol (r = 0.26, p = 0.0835) and resveratrol (r = 0.29, p = 0.0517). Serum levels as biomarkers of intake along with a 24-h recall would be useful in order to investigate the relationship between phytoestrogens and health.
authors.affiliation: a Department of Food Science and.
authors.forename: Susana Alejandra
authors.initials: SA
authors.lastname: Palma-Duran
authors.affiliation: b Department of Nutrition , Centro De Investigación En Alimentación Y Desarrollo, a.C. Hermosillo , Sonora , México.
authors.forename: Graciela
authors.initials: G
authors.lastname: Caire-Juvera
authors.affiliation: a Department of Food Science and.
authors.forename: María del Refugio
authors.initials: Mdel R
authors.lastname: Robles-Burgeño
authors.affiliation: b Department of Nutrition , Centro De Investigación En Alimentación Y Desarrollo, a.C. Hermosillo , Sonora , México.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Ortega-Vélez
authors.affiliation: a Department of Food Science and.
authors.forename: María de Lourdes
authors.initials: Mde L
authors.lastname: Gutiérrez-Coronado
authors.affiliation: a Department of Food Science and.
authors.forename: María del Carmen Bermúdez
authors.initials: Mdel C
authors.lastname: Almada
authors.affiliation: b Department of Nutrition , Centro De Investigación En Alimentación Y Desarrollo, a.C. Hermosillo , Sonora , México.
authors.forename: Karina
authors.initials: K
authors.lastname: Chávez-Suárez
authors.affiliation: b Department of Nutrition , Centro De Investigación En Alimentación Y Desarrollo, a.C. Hermosillo , Sonora , México.
authors.forename: Melissa
authors.initials: M
authors.lastname: Campa-Siqueiros
authors.affiliation: a Department of Food Science and.
authors.forename: Patricia
authors.initials: P
authors.lastname: Grajeda-Cota
authors.affiliation: b Department of Nutrition , Centro De Investigación En Alimentación Y Desarrollo, a.C. Hermosillo , Sonora , México.
authors.forename: María del Socorro
authors.initials: Mdel S
authors.lastname: Saucedo-Tamayo
authors.affiliation: a Department of Food Science and.
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Valenzuela-Quintanar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D004032:Diet; D005260:Female; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D048789:Phytoestrogens / Q000008:administration & dosage / Q000097:blood; D012016:Reference Values
chemical_list: D015415:Biomarkers; D048789:Phytoestrogens
keywords: 24-h recall; HPLC-ESI-MS; coumestrol; flavonoids; lignans; resveratrol