title: Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response.
abstract: Allergic rhinitis is highly prevalent worldwide. Immunotherapy has been shown to control its symptoms, however, up to 30% of patients may not respond. Previous studies of the immunological mechanisms involved in allergen-immunotherapy (AIT) have focused on the humoral and T-cell response and several studies have evaluated some B-cell subpopulations during AIT and their role in immunological tolerance. However, although B and plasma-cell subpopulations are two of the most important cellular subtypes involved in allergic reactions, their relation with AIT efficacy remains unelucidated. The objective was to analyze the effects of immunotherapy on different B and plasma-cell subpopulations and whether these changes correlate with the clinical response to the treatment. Although no changes are found in B-cell subpopulations, responder patients show increased levels of memory B-cells even before the beginning of treatment. Changes in plasma-cell subpopulations are found, mainly in circulating inflammatory plasma-cells that could affect the response to the allergen. Moreover, an early increase of specific-IgG4 and IgG4 secreting-cells was found. All these suggest that the determination of the memory B-cells before the initiation of the treatment, and the quantification of IgG4 and IgG4-secreting-cells in the first months of immunotherapy, could serve as markers for the clinical response to treatment.
authors.affiliation: Research Laboratory-Allergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Tahia D
authors.initials: TD
authors.lastname: Fernández
authors.affiliation: Research Laboratory-Allergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Gómez
authors.affiliation: Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Doña
authors.affiliation: Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Campo
authors.affiliation: Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Rondon
authors.affiliation: Research Laboratory-Allergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Gonzalez
authors.affiliation: Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Gomez
authors.affiliation: Research Laboratory-Allergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Palomares
authors.affiliation: Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Salas
authors.affiliation: Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Blanca
authors.affiliation: Research Laboratory-Allergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.|Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Cristobalina
authors.initials: C
authors.lastname: Mayorga
authors.affiliation: Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Torres
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology / Q000627:therapeutic use*; D000818:Animals; D016175:B-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002454:Cell Differentiation; D019070:Cell Lineage / Q000187:drug effects / Q000276:immunology; D040002:Dermatophagoides pteronyssinus / Q000276:immunology*; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007156:Immunologic Memory; D018655:Lymphocyte Count; D008297:Male; D010950:Plasma Cells / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D065631:Rhinitis, Allergic / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D015415:Biomarkers; D007074:Immunoglobulin G; D007073:Immunoglobulin E