title: New designed nerve conduits with a porous ionic cross-linked alginate/chitisan structure for nerve regeneration.
abstract: A new fabrication process for designing nerve conduits with a porous ionic cross-linked alginate/chitosan composite for nervous regeneration could be prepared. New designed nerve conduits with a porous ionic cross-linked alginate/chitosan composite were developed for nervous regeneration. Nerve conduits (NCs) represent a promising alternative to conventional treatments for peripheral nerve repair. NCs composed of various polysaccharides such as sodium alginate were designed and prepared by lyophilization as potential matrices for tissue engineering. The use of a porous ionic cross-linked alginate/chitosan composite could provide penetration channels that would lead to the products' increasing penetration rate properties. Furthermore, the use of a porous ionic cross-linked alginate/chitosan composite also has a highly cross-linked structure, which would give the products relatively good mechanical properties. Furthermore, the drug could be incorporated into nerve conduits as a new drug-carrying system for nerve regeneration because of its porous and cross-linked structures.
authors.affiliation: Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan.
authors.forename: Jen-Ray
authors.initials: JR
authors.lastname: Chaw
authors.affiliation: Department of Life Science, Fu Jen Catholic University, New Taipei City, Taiwan.
authors.forename: Hsia-Wei
authors.initials: HW
authors.lastname: Liu
authors.affiliation: Department of Materials Science and Engineering, National Tsing-Hua University, Hsinchu, 30013, Taiwan.|Department of Biomedical Engineering, Ming-Chuan University, 5 De Ming Rd., Gui Shan District, Taoyuan, 333, Taiwan.
authors.forename: Yu-Chao
authors.initials: YC
authors.lastname: Shih
authors.affiliation: Department of Biomedical Engineering, Ming-Chuan University, 5 De Ming Rd., Gui Shan District, Taoyuan, 333, Taiwan.|Metal Industries Research & Development Centre, 6F, No.162-24, Sec.3, Hsin-Yi Rd., Taipei 10658, Taiwan.
authors.forename: Ching-Cheng
authors.initials: CC
authors.lastname: Huang
mesh_terms: D020341:Absorbable Implants; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D019544:Equipment Failure Analysis; D020723:Glucuronic Acid / Q000737:chemistry; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D007477:Ions; D008422:Materials Testing; D009416:Nerve Regeneration / Q000502:physiology*; D010525:Peripheral Nerves / Q000254:growth & development*; D016062:Porosity; D011474:Prosthesis Design; D054457:Tissue Scaffolds
chemical_list: D000464:Alginates; D003432:Cross-Linking Reagents; D006603:Hexuronic Acids; D007477:Ions; D020723:Glucuronic Acid; D048271:Chitosan
keywords: Cross-linking reaction; composite; drug-release systems