title: Revealing the complexity of retroviral repression.
abstract: Retroviral restriction is a complex phenomenon that, despite remarkable recent progress, is far from being well understood. In this Preview, we introduce an insightful study by Yang et al. that represents the first attempt to identify the global determinants of retroviral repression in pluripotent mammalian cells.
authors.affiliation: The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Gernot
authors.initials: G
authors.lastname: Wolf
authors.affiliation: The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: todd.macfarlan@nih.gov.
authors.forename: Todd S
authors.initials: TS
authors.lastname: Macfarlan
mesh_terms: D000818:Animals; D053595:Embryonic Stem Cells / Q000821:virology*; D020077:Endogenous Retroviruses / Q000235:genetics*; D011533:Proviruses / Q000235:genetics*