title: Perceptual abnormalities related to sensory gating deficit are core symptoms in adults with ADHD.
abstract: This study investigated and compared perceptual abnormalities related to sensory gating deficit in adult patients with Attention Deficit Disorder with Hyperactivity (A-ADHD) and adult patients with schizophrenia. Subjects were evaluated with the Sensory Gating Inventory (SGI). We compared SGI scores between patients with A-ADHD, patients with schizophrenia and healthy subjects. We also assessed the relationship between SGI scores and clinical symptoms, and evaluated the ability of the SGI to detect perceptual abnormalities in A-ADHD. Seventy adult patients with ADHD reported higher SGI scores than the 70 healthy subjects and the 70 patients with schizophrenia. The inattention factor of the ASRS correlated significantly with the overall SGI score. The ROC AUC for the overall SGI score in the A-ADHD group (versus the healthy group) illustrated good performance. The findings suggest that i) perceptual abnormalities are core symptoms of adult patients with ADHD and ii) the attention of patients with A-ADHD may be involuntarily drowned by many irrelevant environmental stimuli leading to their impaired attention on relevant stimuli. They also confirm that the SGI could be a useful self-report instrument to diagnose the clinical features of A-ADHD.
authors.affiliation: Bordeaux Sleep Clinique, Pellegrin University Hospital, 33076 Bordeaux, France; Bordeaux University, USR CNRS 3413 SANPSY, Research Unit, 33000 Bordeaux, France. Electronic address: jarthur.micoulaud@gmail.com.
authors.forename: Jean-Arthur
authors.initials: JA
authors.lastname: Micoulaud-Franchi
authors.affiliation: Department of Neurology and Sleep Medicine, Gui-de-Chauliac University Hospital, 34000 Montpellier, France; Inserm U1061, Research Unit, 34000 Montpellier, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Lopez
authors.affiliation: Department of Psychiatry, Sainte-Marguerite University Hospital, 13009 Marseille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Vaillant
authors.affiliation: Department of Psychiatry, Sainte-Marguerite University Hospital, 13009 Marseille, France; Aix-Marseille University, EA 3279, Public Health, Chronic Diseases and Quality of Life, Research Unit, 13005 Marseille, France.
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Richieri
authors.affiliation: Department of Psychiatry, Sainte-Marguerite University Hospital, 13009 Marseille, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: El-Kaim
authors.affiliation: Bordeaux Sleep Clinique, Pellegrin University Hospital, 33076 Bordeaux, France; Bordeaux University, USR CNRS 3413 SANPSY, Research Unit, 33000 Bordeaux, France; Department of Children Psychiatry, Charles Perrens Hospital, 33000 Bordeaux, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bioulac
authors.affiliation: Bordeaux Sleep Clinique, Pellegrin University Hospital, 33076 Bordeaux, France; Bordeaux University, USR CNRS 3413 SANPSY, Research Unit, 33000 Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Philip
authors.affiliation: Department of Psychiatry, Sainte-Marguerite University Hospital, 13009 Marseille, France; Aix-Marseille University, EA 3279, Public Health, Chronic Diseases and Quality of Life, Research Unit, 13005 Marseille, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
authors.affiliation: Department of Psychiatry, Sainte-Marguerite University Hospital, 13009 Marseille, France; Aix-Marseille University, EA 3279, Public Health, Chronic Diseases and Quality of Life, Research Unit, 13005 Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Lancon
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D010555:Personality Inventory; D012372:ROC Curve; D012565:Schizophrenic Psychology; D055139:Sensory Gating; D063189:Symptom Assessment / Q000379:methods; D055815:Young Adult
keywords: Adult; Attention Deficit Disorder with Hyperactivity; Perceptual distortion; Questionnaires; Sensory gating