title: Analysis of Cerebral Blood Flow with Single Photon Emission Computed Tomography in Mild Subcortical Ischemic Vascular Dementia.
abstract: OBJECTIVE
  The mechanism of cognitive dysfunction of subcortical ischemic vascular dementia (SIVaD) is not yet fully understood. The objective of this study was to investigate and compare the distribution of regional cerebral perfusion (CP) change in the mild forms of SIVaD, a relatively homogeneous subtype of vascular dementia, using statistical parametric mapping (SPM) analysis of the technetium-99m hexamethylproplyeneamineoxime (Tc-99m HMPAO) single photon emission computed tomography (SPECT).
  
  
  METHODS
  A total of 28 patients with mild SIVaD and 33 healthy controls were prospectively recruited and underwent SPECT imaging studies between January 2012 and May 2013. SPECT was performed to measure the regional CP, and SPM was applied to the analysis of the SPECT data.
  
  
  RESULTS
  The regional CP was significantly decreased in the bilateral insula, anterior and posterior cingulated gyrus, precentral gyrus, and subcallosal gyrus as well as the right inferior parietal lobule in the SIVaD patients compared to the controls (corrected p = 0.01). The pattern of CP abnormality correlated well with those previously reported in later forms of SIVaD.
  
  
  CONCLUSIONS
  Reduction of CP in the brain areas mentioned was present earlier on in the natural course of SIVaD pathophysiology. Our study suggests that cognitive dysfunction of SIVaD may be related to these regional CP deficits.
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seochogu Banpodong 505, 137-701 Seoul, South Korea ; Department of Nuclear Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seochogu Banpodong 505, 137-701 Seoul, South Korea.
authors.forename: Sonya Youngju
authors.initials: SY
authors.lastname: Park
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seochogu Banpodong 505, 137-701 Seoul, South Korea.
authors.forename: Hyukjin
authors.initials: H
authors.lastname: Yoon
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seochogu Banpodong 505, 137-701 Seoul, South Korea.
authors.forename: Narae
authors.initials: N
authors.lastname: Lee
authors.affiliation: Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 665 Bupyeong-dong, Bupyeong-gu, 403-720 Incheon, South Korea.
authors.forename: Jin Kyoung
authors.initials: JK
authors.lastname: Oh
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seochogu Banpodong 505, 137-701 Seoul, South Korea.
authors.forename: Ie Ryung
authors.initials: IeR
authors.lastname: Yoo
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seochogu Banpodong 505, 137-701 Seoul, South Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 665 Bupyeong-dong, Bupyeong-gu, 403-720 Incheon, South Korea.
authors.forename: Yong An
authors.initials: YA
authors.lastname: Chung
keywords: Cerebral blood flow; Dementia; SPECT; Statistical parametric mapping; Subcortical vascular dementia; White matter lesion