title: [Development of Preventive Therapy by Clarification of Mechanisms of Environmental-Factor-Mediated Diseases].
abstract: Environmental factors affecting human health are generally classified into physical, chemical and biological factors. In this review article, we focus on ultraviolet (UV) as a physical factor, heavy metals as a chemical factor and Japanese cedar pollens as a biological factor. Since we believe that progress based on both fieldwork research and experimental research is essential in hygiene study, we included the results of both the research approached. We first introduced the mechanism of development of and prevention of UV-mediated skin melanoma in our experimental research after showing our epidemiological research on UV-mediated DNA damage in humans. We then introduced our evaluation of toxicity and development of a remediation system in our experimental research on heavy metals after showing our fieldwork research for the monitoring of drinking water from wells in Asian countries. We finally introduced the results of pathogenic analysis of pollinosis in our clinical study. We would be very happy if young researchers would re-realize the importance of experimental research as well as epidemiological research in hygiene study.
authors.affiliation: Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine.
authors.forename: Masashi
authors.initials: M
authors.lastname: Kato
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Omata
authors.forename: Machiko
authors.initials: M
authors.lastname: Iida
authors.forename: Mayuko Y
authors.initials: MY
authors.lastname: Kumasaka
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Ohgami
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Cunchao
authors.initials: C
authors.lastname: Zou
authors.forename: Chihiro
authors.initials: C
authors.lastname: Nakano
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kato
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ohgami
authors.forename: Shoko
authors.initials: S
authors.lastname: Ohnuma
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yajima
mesh_terms: D000818:Animals; D032485:Cryptomeria; D004249:DNA Damage; D060766:Drinking Water; D004781:Environmental Exposure / Q000009:adverse effects; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000009:adverse effects; D006801:Humans; D008545:Melanoma / Q000209:etiology / Q000517:prevention & control; D019216:Metals, Heavy / Q000009:adverse effects; D051379:Mice; D011058:Pollen / Q000009:adverse effects; D006255:Rhinitis, Allergic, Seasonal; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control; D014466:Ultraviolet Rays / Q000009:adverse effects; D014874:Water Pollutants, Chemical / Q000009:adverse effects; D014877:Water Pollution, Chemical / Q000517:prevention & control*
chemical_list: D060766:Drinking Water; D004785:Environmental Pollutants; D019216:Metals, Heavy; D014874:Water Pollutants, Chemical