title: High-Dose Oral Ibuprofen in Treatment of Patent Ductus Arteriosus in Full-Term Neonates.
abstract: BACKGROUND
  Patent ductus arteriosus (PDA) is an important risk for heart failure due to left to right shunt in term neonates.
  
  
  OBJECTIVE
  In this study, we evaluated the effect of high dose ibuprofen in closure of PDA in term neonates.
  
  
  METHODS
  We used double dose ibuprofen (20 mg/kg, 10 mg/kg, and 10 mg/kg) for 3 - 30 day old term neonates with PDA who were admitted in the neonatal wards of Shiraz University of Medical Sciences. The results of this study were compared to the data of the previous study in our center which used the low dose of ibuprofen (10 mg/kg, 5 mg/kg, and 5 mg/kg).
  
  
  RESULTS
  29 full term neonates received high-dose ibuprofen, in 18 neonates, PDA was closed after 4 days (62.1% versus 43.3% for the standard dose and 4.7% for the control group in the previous study) (P = 0.001). The results showed no significant correlation between the closure rate and gestational age, postnatal age, sex, and weight. In the 4(th) day of treatment, size of the pulmonic end of ductus arteriosus decreased from 2.09 mm to 0.77 mm compared to 1.68 mm to 0.81 mm in the standard dose of oral ibuprofen and 2.1 mm to 1.4 mm in the control group (P = 0.046).
  
  
  CONCLUSIONS
  This study indicated that high-dose oral ibuprofen was more effective in closing or decreasing the size of PDA.
authors.affiliation: Department of Pediatrics, Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Pourarian
authors.affiliation: Department of Pediatrics, Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Rezaie
authors.affiliation: Cardiac and Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Amoozgar
authors.affiliation: Cardiac and Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Ali-Mohammad
authors.initials: AM
authors.lastname: Shakiba
authors.affiliation: Cardiac and Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Edraki
authors.affiliation: Cardiac and Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Mehdizadegan
keywords: Ductus Arteriosus; High Dose Oral Ibuprofen; Patient; Term Neonate