title: Death in the fast lane: what's next for necroptosis?
abstract: Necroptosis is a form of programmed cell death that is both mechanistically and morphologically distinct from apoptosis, the canonical mechanism of cell suicide. Although early descriptions of necroptosis date back decades, the last 5 years have seen a proliferation of studies of this process. This surge in interest has included the recent publication of several excellent, in-depth reviews of the literature [Chan FK-M et al. (2014) Annu Rev Immunol 33, 141210135520002; Weinlich R & Green DR (2014) Mol Cell 56, 469-480; Silke J et al. (2015) Nat Immunol 16, 689-697; Linkermann A & Green DR (2014) N Engl J Med 370, 455-465]. Rather than contribute another summary to this well-summarized field, in this Minireview I will briefly discuss key recent findings, then touch on some of the major outstanding questions - the known unknowns - that remain.
authors.affiliation: Department of Immunology, University of Washington, Seattle, WA, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Oberst
mesh_terms: D000067531:Alarmins / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000502:physiology; D053181:Caspase 8 / Q000502:physiology; D016923:Cell Death / Q000276:immunology / Q000502:physiology*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000502:physiology; D008954:Models, Biological; D009336:Necrosis; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology; D000069452:Pathogen-Associated Molecular Pattern Molecules / Q000378:metabolism; D011494:Protein Kinases / Q000502:physiology; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000502:physiology
chemical_list: D000067531:Alarmins; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D051034:Inhibitor of Apoptosis Proteins; D000069452:Pathogen-Associated Molecular Pattern Molecules; D011494:Protein Kinases; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; D053181:Caspase 8
keywords: MLKL; RIPK1; RIPK3; apoptosis; caspase-8; necroptosis