title: Differential Diagnosis for Multiple Sclerosis-related Optic Neuritis.
abstract: OBJECTIVE
  To analyze clinical features and main causes of multiple sclerosis-related optic neuritis (MS-ON), providing evidence for the differential diagnosis of MS-ON.
  
  
  METHODS
  Clinical data were collected from 527 patients, 123 males and 404 females, diagnosed with MS-ON between June 2008 and June 2013. Visual acuity, optometry, visual field, slit-lamp microscopy, indirect ophthalmoscopy (20D), optical coherence tomography (OCT) and magnetic resonance imaging (MRI) were performed. Venous blood was sampled for detection of autoimmune antibodies and Aquaporin (AQP- 4).
  
  
  RESULTS
  Fifty nine cases were diagnosed with neuromyelitis optica-related optic neuritis (NMO-ON), 27 Sjogren's syndrome-related optic neuropathy, 22 tumors, 21 anterior ischemic optic neuropathy, 15 radiation-induced optic neuropathy, 14 optic neuropathy-related infection, 17 genetic eye diseases and 10 open angle glaucoma. Among 168 MS-ON patients undergoing optic nerve MRI,90 cases (53.57%) had a lesion < 15 mm in size, 15-30 mm in 76 (45.24%) and > 30 mm in two (1.19%).
  
  
  CONCLUSIONS
  MS-ON is more commonly misdiagnosed with NMO-ON and Sjogren's syndrome, when compared to optic neuropathy, tumors and ischemic optic neuropathy.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Liang
authors.forename: Shihui
authors.initials: S
authors.lastname: Wei
authors.forename: Hongyang
authors.initials: H
authors.lastname: Li
mesh_terms: D001323:Autoantibodies / Q000097:blood; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications*; D009471:Neuromyelitis Optica / Q000150:complications; D009902:Optic Neuritis / Q000175:diagnosis* / Q000209:etiology*; D018917:Optic Neuropathy, Ischemic / Q000150:complications; D012859:Sjogren's Syndrome / Q000150:complications; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D001323:Autoantibodies