title: Crystal structure of 1,3-dihy-droxy-2-(hy-droxy-meth-yl)propan-2-aminium 2-(4-iso-butyl-phen-yl)propano-ate: a simple organic salt of racemic ibuprofen.
abstract: In the title organic salt of ibuprofen with trometamol, C4H12NO3 (+)·C13H17O2 (-), the carb-oxy-lic acid group of ibuprofen has transferred its proton to the amino N atom of trometamol. In the crystal, the trometamol cations are linked via N-H⋯O hydrogen bonds, forming chains along [001]. To these chains are attached the ibuprofen anions via O-H⋯O and N-H⋯O hydrogen bonds. The chains are linked via further N-H⋯O and O-H⋯O hydrogen bonds, forming sheets parallel to (100). Two C atoms of the propano-ate substituent in the ibuprofen anion are disordered over two sets of sites and were refined with a fixed occupancy ratio of 0.7:0.3.
authors.affiliation: Department of Chemistry and Chemical Engineering, Minjiang University, Fuzhou 350108, People's Republic of China.
authors.forename: Benyong
authors.initials: B
authors.lastname: Lou
keywords: chains; crystal structure; hydrogen bonding; ibuprofen; mol­ecular salt; sheets; trometamol