title: Changes in the Mother-Placenta-Fetus System Under the Effect of α-Tocopherol in Albino Rats with Normal Pregnancy.
abstract: The effects of α-tocopherol on the function of the mother-placenta-fetus system and structural changes in the placenta in normal pregnancy were studied in albino rats. The results indicated that inhibition of free radical processes by injections of α-tocopherol in normal pregnancy led to disorders in the feto-maternal circulation, which was proven by morphological changes in the placenta. The disorders in the uteroplacental circulation manifested in the development of small-for-date fetuses and erythrocytosis.
authors.affiliation: Ivanovo State Medical Academy, the Ministry of Health of the Russian Federation, Ivanovo, Russia. asivanova@mail.ru.
authors.forename: A S
authors.initials: AS
authors.lastname: Ivanova
authors.affiliation: V. N. Gorodkov Research Institute of Maternity and Childhood, the Ministry of Health of the Russian Federation, Ivanovo, Russia.
authors.forename: L P
authors.initials: LP
authors.lastname: Peretyatko
authors.affiliation: V. N. Gorodkov Research Institute of Maternity and Childhood, the Ministry of Health of the Russian Federation, Ivanovo, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Sitnikova
authors.affiliation: Ivanovo State Medical Academy, the Ministry of Health of the Russian Federation, Ivanovo, Russia.|V. N. Gorodkov Research Institute of Maternity and Childhood, the Ministry of Health of the Russian Federation, Ivanovo, Russia.
authors.forename: S B
authors.initials: SB
authors.lastname: Nazarov
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005333:Fetus / Q000187:drug effects*; D015227:Lipid Peroxidation; D008431:Maternal-Fetal Exchange; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress; D010920:Placenta / Q000187:drug effects* / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism; D024502:alpha-Tocopherol / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D042582:Vascular Endothelial Growth Factor C; D019001:Nitric Oxide Synthase; D024502:alpha-Tocopherol
keywords: morphology; mother–placenta–fetus system; α-tocopherol