title: Matrix-remodeling associated 5 as a novel tissue biomarker predicts poor prognosis in non-small cell lung cancers.
abstract: BACKGROUND
  Matrix-remodeling associated 5 (MXRA5) has recently been one of the frequently mutated gene but its role in non-small cell lung cancer (NSCLC) remains unclear.
  
  
  OBJECTIVE
  To identify whether MXRA5 could be applied as a novel prognostic marker for NSCLC.
  
  
  RESULTS
  In this study, we proved that mRNA and protein expression of MXRA5 in 166 NSCLC patients' tissues by Quantitative Real-Time PCR and immunohistochemical staining respectively. Moreover, the correlation between MXRA5 protein expression and clinicopathological features and prognosis in NSCLC patients was evaluated. Our results revealed that the over-expression of MXRA5 was significantly correlated with age (P = 0.049), differentiation (P = 0.003), tumor-node-metastasis (TNM) stage (P = 0.017) and smoking cigarette (P = 0.007). In addition, it also showed that patients with higher MXRA5 protein expression had significantly shorter overall survival (P < 0.001). Multivariate analysis indicated that over-expression of MXRA5 protein was an independent prognostic factor for NSCLC.
  
  
  CONCLUSIONS
  MXRA5 protein is aberrantly expressed in NSCLC and the high MXRA5 expression is correlated with tumor progression and overall survival. These results indicated the potential value of MXRA5 as a novel therapeutic target for the treatment of NSCLC.
authors.affiliation: Department of Cardiothoracic surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Respiratory Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Cardiothoracic surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Cardiothoracic surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Ophthalmology and optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: William Robert
authors.initials: WR
authors.lastname: Kwapong
authors.affiliation: Department of Cardiothoracic surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Ju
authors.initials: J
authors.lastname: Mei
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011509:Proteoglycans / Q000096:biosynthesis* / Q000235:genetics; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C575909:MXRA5 protein, human; D011509:Proteoglycans
keywords: Matrix-remodeling associated 5; biomarker; non-small cell lung cancer; prognosis