title: [Genetic Association of ADRA2A and ADRB3 Genes with Metabolic Syndrome among the Tatars].
abstract: An association study was performed for genetic polymorphisms in ADRB3 (rs4994) and ADRA2A (rs1800544, rs553668) genes to estimate their effect on quantitative parameters, including glucose, insulin, and HOMA-IR index in women from the Tatar population of Russia. It has been shown that CT and CC are associated with metabolic syndrome and increased insulin. It was shown that ADRA2A (rs1800544) gene polymorphism was associated with high levels of insulin and an increased HOMA-IR index in GG- and GC-genotype carriers.
authors.forename: O V
authors.initials: OV
authors.lastname: Kochetova
authors.forename: T V
authors.initials: TV
authors.lastname: Viktorova
authors.forename: O E
authors.initials: OE
authors.lastname: Mustafina
authors.forename: A A
authors.initials: AA
authors.lastname: Karpov
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
mesh_terms: D001786:Blood Glucose / Q000235:genetics; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D007328:Insulin / Q000097:blood / Q000235:genetics; D024821:Metabolic Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012426:Russia / Q000208:ethnology
chemical_list: C547768:ADRA2A protein, human; C568534:ADRB3 protein, human; D001786:Blood Glucose; D007328:Insulin; D018341:Receptors, Adrenergic, alpha-2; D022702:Receptors, Adrenergic, beta-3