title: Comparing Endurance and Resistance Training with Standard Care during Chemotherapy for Patients with Primary Breast Cancer.
abstract: OBJECTIVE
  Previous findings suggest that physical activity during breast cancer treatment can reduce side-effects and improve clinical outcome. In the present study, endurance (ET) and resistance training (RT) in 67 patients with breast cancer undergoing chemotherapy were compared with standard-care (SC).
  
  
  METHODS
  Study end-points were muscular strength, endurance and subjective perceived exertion during the endurance stress test (Borg scale) and quality of life (QoL) measured by standardized report form of the European Organization for Research and Treatment of Cancer (EORTC QLQ C30+BR23) before and after 12 weeks of treatment.
  
  
  RESULTS
  The RT and ET groups improved significantly in muscular strength compared to the SC group. Endurance decreased in all groups after treatment (p>0.05 for all groups); the maximum endurance loss occurred in the SC group (p=0.001). The subjective perceived exertion at 100 W remained stable in the RT group (p=1.00) decreased most in the SC group (p=0.3) and to a lesser extent in the ET group (p=0.02). In the RT group, QoL improved significantly (p=0.011). There was also a trend for improvement of QoL in the ET group (p=0.09) whereas that of the SC group decreased (p=0.8).
  
  
  CONCLUSIONS
  Results highlight improvements in strength, endurance and QoL from exercise training and support its implementation in standard of care during chemotherapy for patients with breast cancer.
authors.affiliation: Comprehensive Cancer Center North, Kiel, Germany Thorsten.schmidt@uksh.de.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schmidt
authors.affiliation: Institute of Sport Science, Kiel, Germany.
authors.forename: Burkhard
authors.initials: B
authors.lastname: Weisser
authors.affiliation: University Hospital for Women, Kiel, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Dürkop
authors.affiliation: University Hospital for Women, Kiel, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Jonat
authors.affiliation: University Hospital for Women, Kiel, Germany.
authors.forename: Marion
authors.initials: M
authors.lastname: Van Mackelenbergh
authors.affiliation: Comprehensive Cancer Center North, Kiel, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Röcken
authors.affiliation: University Hospital for Women, Kiel, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Mundhenke
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000534:rehabilitation*; D018479:Early Intervention, Educational; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D053580:Muscle Strength; D009367:Neoplasm Staging; D010807:Physical Endurance; D011379:Prognosis; D011446:Prospective Studies; D055070:Resistance Training; D059039:Standard of Care; D011795:Surveys and Questionnaires
keywords: Breast cancer; chemotherapy; exercise; physical activity