title: Successful treatment of HCV-associated cryoglobulinemia with ombitasvir/paritaprevir/ritonavir, dasabuvir and ribavirin: A case report.
abstract: Cryoglobulinemia is an important extrahepatic manifestation of chronic hepatitis C virus infection. Current treatments are suboptimal, resulting in relapse or refractoriness in 30-40% of patients. Hereby, we describe the case of a 40-year old man with severe hepatitis C virus-associated cryoglobulinemia, effectively treated with an interferon-free combination regimen. The patient was treated for 12 weeks with ombitasvir/paritaprevir/ritonavir, dasabuvir and ribavirin. Rapid clinical and immunological response, i.e., the resolution of symptoms and disappearance of serum cryoglobulins, ensued as early as 4 weeks after initiating direct acting antiviral therapy. Our reported case directs the attention to the possible consequences and importance of new, effective, interferon-free antiviral treatments in devastating lymphoproliferative and immunological manifestations of chronic hepatitis C virus infection.
authors.affiliation: St István and St László Hospital, Hepatology Center, 1097, Nagyvárad sqr. 1, Budapest, Hungary. Electronic address: michael@makara.md.
authors.forename: Mihály
authors.initials: M
authors.lastname: Makara
authors.affiliation: Semmelweis University, Doctoral School for Clinical Medicine, 1085, Üllői str. 26, Budapest, Hungary; Eberhard Karl University, Institute for Tropical Medicine, 72074, Wilhelmstr. 27, Tuebingen, Germany. Electronic address: mihaly.sulyok@uni-tuebingen.de.
authors.forename: Mihály
authors.initials: M
authors.lastname: Sulyok
authors.affiliation: St István and St László Hospital, Department of Hematology and Stem Cell Transplantation, 1097, Nagyvárad sqr.1, Budapest, Hungary. Electronic address: csacsotto@gmail.com.
authors.forename: Ottó
authors.initials: O
authors.lastname: Csacsovszki
authors.affiliation: Eberhard Karl University, Institute for Tropical Medicine, 72074, Wilhelmstr. 27, Tuebingen, Germany. Electronic address: dr.sulyokzita@gmail.com.
authors.forename: Zita
authors.initials: Z
authors.lastname: Sulyok
authors.affiliation: St István and St László Hospital, Department of Hematology and Stem Cell Transplantation, 1097, Nagyvárad sqr.1, Budapest, Hungary. Electronic address: drvnistvan@gmail.com.
authors.forename: István
authors.initials: I
authors.lastname: Vályi-Nagy
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D003449:Cryoglobulinemia / Q000175:diagnosis* / Q000473:pathology*; D004359:Drug Therapy, Combination / Q000379:methods; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents
keywords: Cryoglobulinemia; Direct acting antivirals; HCV