title: Pertussis in children in the İstanbul Faculty of Medicine: results for four years.
abstract: We investigated the frequency of pertussis among children in the İstanbul Faculty of Medicine Hospital during a period of four years. Clinical specimens were obtained from children who exhibited symptoms of whooping cough; a portion of the cases were confirmed microbiologically by PCR as pertussis. A total of 410 nasopharyngeal aspirates were taken for detection of Bordetella pertussis/parapertussis. The age groups of the patients were 0-4 months (n=201), >4 -12 months (n=49), 1-4 years (n=79), 5-9 years (n=46), 10-14 years (n=27) and >15 years (n=8). 106 (26%) of all samples were positive for B. pertussis/parapertussis by the PCR method. The Bordetella PCR positivity rates were 36% in 2010, 29% in 2011, 15% in 2012 and 15% in 2013. Due to administration of the DTaP-IPV vaccination at seven years of age starting in 2010, pertussis was not detected in the 5-9 age group after that year. According to this result, the five doses of pertussis vaccination administered as the national vaccine scheme are effective in protecting against the infection. A booster dose for adolescents at 14 years of age as well as a cocoon strategy might also be considered in our country.
authors.affiliation: Department of Medical Microbiology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul, Turkey. loksuz34@yahoo.com.
authors.forename: Lütfiye
authors.initials: L
authors.lastname: Öksüz
authors.forename: Selda
authors.initials: S
authors.lastname: Hançerli
authors.forename: Ayper
authors.initials: A
authors.lastname: Somer
authors.forename: Nuran
authors.initials: N
authors.lastname: Salman
authors.forename: Nezahat
authors.initials: N
authors.lastname: Gürler
mesh_terms: D000293:Adolescent; D001886:Bordetella pertussis / Q000235:genetics / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016133:Polymerase Chain Reaction; D013997:Time Factors; D014421:Turkey / Q000453:epidemiology; D014917:Whooping Cough / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial