title: [THE EFFECT OF CHRONIC INTOXICATION WITH LOW DOSES OF CHLORPYRIFOS ON THE BEHAVIORAL PARAMETERS OF FEMALE RATS].
abstract: We explored the effect of chronic chlorpyrifos intake on the behavior of female laboratory rats. The animals were exposed to chlorpyrifos in doses 5 and 10 mg/kg daily for a month long and tested with behavioral tests: Morris water maze, Open field test, and Dark/light box. Everyday chlorpyrifos intake in dose 10 mg/kg was revealed to cause long- and short-term spatial memory lesion, decrease in total activity, sharp changes in the level of anxiety (it significantly increased at the start of xenobiotic intake, and then normalized with time). Similar trends, though less intense, were observed in the group exposed to 5 mg/kg chlorpyrifos. From the survey results it can be concluded that long-term (30 days long) intake of even low doses of chlorpyrifos can cause adverse effects on the functional state of nervous system.
authors.forename: S V
authors.initials: SV
authors.lastname: Grabovska
authors.forename: Y T
authors.initials: YT
authors.lastname: Salyha
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000503:physiopathology / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects*; D004390:Chlorpyrifos / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D018782:Maze Learning / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D065852:Spatial Memory / Q000187:drug effects*
chemical_list: D002800:Cholinesterase Inhibitors; D007306:Insecticides; D004390:Chlorpyrifos