title: [Effect of Ju-Pi-Tang on Cisplatin-induced Emetic Model in Minks].
abstract: OBJECTIVE
  To study the antiemetic effect of Ju-Pi-Tang from Jin Kui Yao Lue on cisplatin-induced emetic model in minks, and to observe the immunoexpression of peripheral and central c-fos and substance P.
  
  
  METHODS
  The minks were randomly divided into blank control group, Ju-Pi-Tang blank control group, model group, ondansetron group, aprepitant group, Ju-Pi-Tang (in high-, mid-, and low-dose) groups. Every group was administered with the antiemetic agent or distilled water on 24 h before cisplatin injection. The antiemetic effect of drugs was investigated in the emetic model of minks induced by cisplatin in 72 h observation. Immunohistochemistry was used to compare the differences of c-fos and substance P expression in the area postrema of brain and distal ileum tissues.
  
  
  RESULTS
  During observation period,compared with model group,the frequency cisplatin induced retching and vomiting was significantly reduced by Ju-Pi-Tang in high- and mid-dose groups, during the 0-24 h acute period, the number of retching of Ju-Pi-Tang in high-dose group was decreased more than aprepitant group, during the 24-72 h delayed period, the number of both retching and vomiting was decreased more than ondansetron group, after 72 h of cisplatin administration, compared with model group, the grey levels of c-fos and substance P expression in distal ileum and brain tissues of Ju-Pi-Tang groups were higher significantly.
  
  
  CONCLUSIONS
  Ju-Pi-Tang has a good effect against cisplatin-induced emesis in minks.
authors.forename: Ran-ran
authors.initials: RR
authors.lastname: Liu
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Yang
authors.forename: Yu-ling
authors.initials: YL
authors.lastname: Yang
authors.forename: Zhan-tao
authors.initials: ZT
authors.lastname: Liu
authors.forename: Wang
authors.initials: W
authors.lastname: Yue
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D000077608:Aprepitant; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002945:Cisplatin / Q000009:adverse effects*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D008907:Mink; D009025:Morpholines / Q000494:pharmacology; D017294:Ondansetron / Q000494:pharmacology; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D004365:Drugs, Chinese Herbal; D009025:Morpholines; D000077608:Aprepitant; D017294:Ondansetron; D002945:Cisplatin