title: [Modifications of immunity in obesity: The impact on the risk of infection].
abstract: Incidence of obesity is constantly rising all over the world; obesity has developed into an important problem of public health. Clinical experience, supported by many clinical trials, shows that obesity constitutes a risk factor for numerous cardiovascular, metabolic, cancer and even infectious diseases. In this revue we summarize the present knowledge on immunological properties and functions of adipose tissue and their modifications in obese subjects, with a bending to a potentially deleterious chronic inflammatory state. We will discuss the negative impact of this chronic inflammation on physiological acute inflammatory reaction during infectious episodes. However, the modifications of anti-infectious immune response in obese subjects are not well known at present and need further investigations.
authors.affiliation: Service de médecine interne et de maladies infectieuses, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France. Electronic address: rmeckenstock@ch-versailles.fr.
authors.forename: R
authors.initials: R
authors.lastname: Meckenstock
authors.affiliation: Service de médecine interne et de maladies infectieuses, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: A
authors.initials: A
authors.lastname: Therby
mesh_terms: D000273:Adipose Tissue / Q000276:immunology / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D007239:Infections / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D009765:Obesity / Q000276:immunology* / Q000503:physiopathology
chemical_list: D016207:Cytokines
keywords: Immunity; Immunité; Infection; Obesity; Obésité