title: Treating non-motor symptoms of Parkinson's disease with transplantation of stem cells.
abstract: Parkinson's disease (PD) treatment-based research has focused on developing therapies for the management of motor symptoms. Non-motor symptoms do not respond to treatments targeting motor deficits, thus necessitating an urgent need to develop new modalities that cater to both motor and non-motor deficits. Stem cell transplantation is potentially therapeutic for PD, but the disease non-motor symptoms have been primarily neglected in such cell therapy regimens. Many types of stem cells are currently available for transplantation therapy, including adult tissue (e.g., bone marrow, placenta)-derived mesenchymal stem cells. The fact that mesenchymal stem cells can replace and rescue degenerated dopaminergic and non-dopaminergic cells suggests their potential for the treatment of motor as well as non-motor symptoms of PD, which is discussed in this article.
authors.affiliation: a Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.
authors.forename: Paolina
authors.initials: P
authors.lastname: Pantcheva
authors.affiliation: a Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.
authors.forename: Stephanny
authors.initials: S
authors.lastname: Reyes
authors.affiliation: a Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Hoover
authors.affiliation: a Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.
authors.forename: Sussannah
authors.initials: S
authors.lastname: Kaelber
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Borlongan
mesh_terms: D000818:Animals; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*
keywords: Parkinson’s disease; mesenchymal stem cells; motor symptoms; non-motor symptoms; stem cell therapy