title: The asymmetric synthesis of polycyclic 3-spirooxindole alkaloids via the cascade reaction of 2-isocyanoethylindoles.
abstract: A highly enantioselective dearomative cascade reaction between 2-isocyanoethylindoles and 3-alkenyl-oxindoles was realized using a chiral N,N'-dioxide-Mg(II) complex catalyst. This reaction provides a straightforward access to polycyclic 3-spirooxindoles bearing cyclopenta[b]indole units with four contiguous stereocenters in excellent yields and moderate to good stereoselectivities via a Michael/Friedel-Crafts/Mannich cascade.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
authors.forename: Hongjiang
authors.initials: H
authors.lastname: Mei
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
authors.forename: Baiwei
authors.initials: B
authors.lastname: Ma
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D000078183:Oxindoles; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D007211:Indoles; D008024:Ligands; D000078183:Oxindoles; D011083:Polycyclic Compounds; D013141:Spiro Compounds; C022960:2-oxindole