title: Long-term immunogenicity of single dose of live attenuated hepatitis A vaccine in Indian children.
abstract: OBJECTIVE
  To assess immunogenicity of a single dose of live attenuated hepatitis A vaccine in Indian children, ten years after immunization.
  
  
  METHODS
  Of 143 children vaccinated in 2004, 121 children were evaluated in 2014, clinically and for anti-HAV antibodies.
  
  
  RESULTS
  13 children were early vaccine failures who received two doses of HAV vaccine subsequently. 106 (98%) of 108 remaining children had seroprotective levels with a geometric mean titer of 100.5 mIU/mL. On analysis of all 121 children, the immunogenicity was 87.6%.
  
  
  CONCLUSIONS
  Single dose of live attenuated hepatitis A vaccine provides long-term immunity in Indian children.
authors.affiliation: Department of Pediatrics, KEM Hospital Research Centre, Pune; and *Department of Medical Affairs, Wockhardt Limited, Mumbai; India. Correspondence to: Dr Sheila Bhave, Department of Pediatrics, KEM Hospital Research Centre, Rasta Peth, Pune 411 011, India. kemhrc@vsnl.net.
authors.forename: Sheila
authors.initials: S
authors.lastname: Bhave
authors.forename: Amita
authors.initials: A
authors.lastname: Sapru
authors.forename: Ashish
authors.initials: A
authors.lastname: Bavdekar
authors.forename: Vaibhavi
authors.initials: V
authors.lastname: Kapatkar
authors.forename: Amey
authors.initials: A
authors.lastname: Mane
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006506:Hepatitis A / Q000517:prevention & control*; D035922:Hepatitis A Antibodies / Q000097:blood*; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006801:Humans; D007194:India; D007223:Infant; D014613:Vaccines, Attenuated / Q000276:immunology*; D055815:Young Adult
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D014613:Vaccines, Attenuated