title: Effect of nutritional counseling and long term isomaltulose based liquid formula (MHN-01) intake on metabolic syndrome.
abstract: The isomaltulose based liquid formula (MHN-01), suppresses postprandial plasma glucose and insulin levels in healthy persons and patients with impaired glucose tolerance (IGT) or type 2 diabetes. MHN-01 intake as a part of breakfast also suppresses glucose and insulin levels after lunch, suggesting second meal effect. The objective of this study was to investigate the effects of nutritional counseling and long-term (24 weeks) MHN-01 ingestion on biomarkers of metabolic syndrome. Forty-one subjects with criteria of metabolic syndrome participated in this study composed with the control period (0-12 week) followed by nutritional counseling and the experimental period (12-36 week) followed by 200 kcal (837 kJ) of MHN-01 or dextrin-based standard balanced liquid formula (SBF) loading as a part of breakfast. In 16 of 41 subjects became to out of criteria for liquid formula loading study during control period (unqualified group). In the unqualified group, several biomarkers were improved. In experimental period, serum HbA1c levels significantly increased in SBF group (n = 12) but did not change in MHN-01 group (n = 10). Thus, intake of 837 kJ MHN-01 as a part of breakfast may be effective for suppression of deteriorating glucose metabolism in metabolic syndrome.
authors.affiliation: Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Takeda
authors.affiliation: Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
authors.forename: Hisami
authors.initials: H
authors.lastname: Yamanaka-Okumura
authors.affiliation: Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Taketani
authors.affiliation: Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Nobuya
authors.initials: N
authors.lastname: Inagaki
authors.affiliation: Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Hosokawa
authors.affiliation: Department of Clinical Nutrition, School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Shide
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maegawa
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kondo
authors.affiliation: Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kawasaki
authors.affiliation: Division of Dietary Service, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Shinozaki
authors.affiliation: Endocrinology and Metabolism, Tokushima University Medical and Dental Hospital, 2-50-1 Kuramoto-cho, Tokushima 770-8503, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Fujinaka
authors.affiliation: Director, Matsubara Mayflower Hospital, 944-55 Fujita, Kato, Hyogo 673-1462, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Matsubara
authors.affiliation: Faculty of Statistic and Computer Science, College of Nursing Art and Science, University of Hyogo, 13-71 Kitaoji-cho, Akashi, Hyogo 673-8588, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Katayama
authors.affiliation: Food Science Research Labs., R&D Div., Meiji Co., Ltd., 540 Narita, Odawara, Kanagawa 250-0862, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Sasaki
authors.affiliation: Food Science Research Labs., R&D Div., Meiji Co., Ltd., 540 Narita, Odawara, Kanagawa 250-0862, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kawashima
authors.affiliation: Food Science Research Labs., R&D Div., Meiji Co., Ltd., 540 Narita, Odawara, Kanagawa 250-0862, Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Aonuma
keywords: diabetes; impaired glucose tolerance; insulin; postprandial hyperglycemia