title: Fbxw7 suppresses cancer metastasis by inhibiting niche formation.
abstract: Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.
authors.affiliation: Department of Molecular and Cellular Biology; Medical Institute of Bioregulation; Kyushu University ; Fukuoka, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Yumimoto
authors.affiliation: Department of Molecular and Cellular Biology; Medical Institute of Bioregulation; Kyushu University ; Fukuoka, Japan.
authors.forename: Keiichi I
authors.initials: KI
authors.lastname: Nakayama
keywords: F-box protein; chemokine; metastasis; niche; ubiquitin ligase