title: miR-155 releases the brakes on antitumor T cells.
abstract: Homeostatic γCcytokines are essential to support the expansion and function of tumor-specific T cells, but their effects are constrained by suppressor of cytokine signaling (SOCS) proteins as well as phosphoinositide and tyrosine-specific phosphatases. The microRNA miR-155 counteracts these inhibitory hurdles to potentiate intracellular cytokine signaling and T cell antitumor immunity.
authors.affiliation: Experimental Transplantation and Immunology Branch; Center for Cancer Research; National Cancer Institute; National Institutes of Health ; Bethesda, MD USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Experimental Transplantation and Immunology Branch; Center for Cancer Research; National Cancer Institute; National Institutes of Health ; Bethesda, MD USA.
authors.forename: Luca
authors.initials: L
authors.lastname: Gattinoni
keywords: Ptpn2; SHIP-1; SOCS-1; adoptive immunotherapy; homeostatic γC cytokines; lymphodepletion; miR-155