title: Large-Scale Nanoelectrode Arrays to Monitor the Dopaminergic Differentiation of Human Neural Stem Cells.
abstract: A novel cell-based biosensing platform is developed using a combination of sequential laser interference lithography and electrochemical deposition methods. This enables the sensitive discrimination of dopaminergic cells from other types of neural cells in a completely nondestructive manner. This platform and detection strategy may become an effective noninvasive in situ monitoring tool that can be used to determine stem cell fate for various regenerative applications.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
authors.forename: Tae-Hyung
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.|Department of Chemical & Biomolecular Engineering, Sogang University, Seoul, 121-742, Republic of Korea.
authors.forename: Cheol-Heon
authors.initials: CH
authors.lastname: Yea
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
authors.forename: Sy-Tsong Dean
authors.initials: ST
authors.lastname: Chueng
authors.affiliation: Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
authors.forename: Perry To-Tien
authors.initials: PT
authors.lastname: Yin
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Conley
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
authors.forename: Kholud
authors.initials: K
authors.lastname: Dardir
authors.affiliation: School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 500-712, Republic of Korea.
authors.forename: Yusin
authors.initials: Y
authors.lastname: Pak
authors.affiliation: School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 500-712, Republic of Korea.
authors.forename: Gun Young
authors.initials: GY
authors.lastname: Jung
authors.affiliation: Department of Chemical & Biomolecular Engineering, Sogang University, Seoul, 121-742, Republic of Korea.
authors.forename: Jeong-Woo
authors.initials: JW
authors.lastname: Choi
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.|Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
authors.forename: Ki-Bum
authors.initials: KB
authors.lastname: Lee
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D002454:Cell Differentiation; D004298:Dopamine / Q000378:metabolism; D059290:Dopaminergic Neurons / Q000166:cytology / Q000378:metabolism*; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D006801:Humans; D007980:Levodopa / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D016716:PC12 Cells; D051381:Rats; D017971:Tin Compounds / Q000737:chemistry
chemical_list: D017971:Tin Compounds; D007980:Levodopa; C109984:indium tin oxide; D006046:Gold; D004298:Dopamine
keywords: dopaminergic differentiation; electrochemical detection; large-scale nanopatterning; nanoelectrode arrays; neural stem cells