title: Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy.
abstract: The interaction of simple and ternary Cu(II) complexes of 1,10-phenanthrolines with DNA has been studied extensively because of their various interesting and important functions such as DNA cleavage activity, cytotoxicity towards cancer cells, and DNA based asymmetric catalysis. Such functions are closely related to the DNA binding modes of the complexes such as intercalation, groove binding, and electrostatic surface binding. A variety of spectroscopic methods have been used to study the DNA binding mode of the Cu(II) complexes. Of all these methods, DNA-fiber electron paramagnetic resonance (EPR) spectroscopy affords unique information on the DNA binding structures of the complexes. In this review we summarize the results of our DNA-fiber EPR studies on the DNA binding structure of the complexes and discuss them together with the data accumulated by using other measurements.
authors.affiliation: Department of Applied Chemistry, Chuo University, Kasuga, Bunkyou-ku, Tokyo 112-8551, Japan. chikira@kc.chuo-u.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Chikira
authors.affiliation: Department of Pharmaceutical Chemistry, International Medical University, Kuala Lumpur 57000, Malaysia. NgChewHee@imu.edu.my.
authors.forename: Chew Hee
authors.initials: CH
authors.lastname: Ng
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India. palaniandavarm@gmail.com.
authors.forename: Mallayan
authors.initials: M
authors.lastname: Palaniandavar
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D007364:Intercalating Agents / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D008958:Models, Molecular; D010618:Phenanthrolines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D056831:Coordination Complexes; D007364:Intercalating Agents; D008024:Ligands; D010618:Phenanthrolines; D003300:Copper; D004247:DNA; C025205:1,10-phenanthroline
keywords: 1,10-phenanthrolines; Cu(II) complexes; DNA binding structures; DNA conformation; DNA fiber; electron paramagnetic resonance