title: APOE Affects the Volume and Shape of the Amygdala and the Hippocampus in Mild Cognitive Impairment and Alzheimer's Disease: Age Matters.
abstract: This paper examines how age intervenes in the effects of APOE ɛ4 allele on the volume and shape morphometrics of the hippocampus and the amygdala in mild cognitive impairment (MCI) and Alzheimer's disease. We evaluate the structural morphological differences between ɛ4 carriers and non-carriers in two age-dependent subgroups; younger than 75 years (Young-Old) and older than 80 years (Very-Old). While we show that the four structures of interest atrophy significantly in the ɛ4 carriers, relative to the non-carriers, of the Young-Old group, this effect is not observed in their Very-Old counterparts. The structures in the right hemisphere are found to be more affected by the APOE genotype than those in the left hemisphere and we identify the relevant regions in which significant atrophy occurs to be parts of the basolateral, centromedial, and lateral nucleus subregions of the amygdala and the CA1 and subiculum subregions of the hippocampus. We also observe that the APOE genotype only affects MCI patients that deteriorated to dementia within 3 years while leaving their "non-converting" counterparts unaffected.
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Dominic
authors.initials: D
authors.lastname: Holland
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.|Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Anders M
authors.initials: AM
authors.lastname: Dale
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.|Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.|Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Michael I
authors.initials: MI
authors.lastname: Miller
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000473:pathology*; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology*; D000679:Amygdala / Q000473:pathology*; D053327:Apolipoprotein E4 / Q000235:genetics*; D060825:Cognitive Dysfunction / Q000235:genetics / Q000473:pathology*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006579:Heterozygote; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009929:Organ Size
chemical_list: D053327:Apolipoprotein E4
keywords: Age intervention; Alzheimer’s disease; amygdala; apolipoprotein E; conversion; hippocampus; mild cognitive impairment; shape morphometrics