title: Mind the gap: the mismatch between clinical and imaging metrics in ALS.
abstract: Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and as such deliver biomarkers relevant to diagnosis, prognosis and monitoring disease progression. However, a correlation between imaging parameters and clinical metrics has thus far been inconsistent across studies. We discuss the contributing factors to this clinical-imaging correlation gap as well as its implications for future research.
authors.affiliation: a Department of Neurology , Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht , Utrecht , The Netherlands.
authors.forename: Esther
authors.initials: E
authors.lastname: Verstraete
authors.affiliation: b Nuffield Department of Clinical Neurosciences , Oxford University , Oxford , UK.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Turner
authors.affiliation: c Hans-Berger Department of Neurology , University Hospital Jena , Jena , Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Grosskreutz
authors.affiliation: d Neuroimaging Research Unit and Department of Neurology , Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University , Milan , Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
authors.affiliation: e Department of Neurology , University of Miami Miller School of Medicine , Miami, Florida , USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Benatar
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology* / Q000503:physiopathology; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009046:Motor Neurons / Q000473:pathology*; D011712:Pyramidal Tracts / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology*