title: Integrate and boost: bioscaffolds nurture the cardiac regenerative paradigm.
abstract: The traditional cardiac regenerative paradigm using non-modified adult stem cells with various routes of delivery into the myocardial target has thus far yielded unconvincing clinical outcomes. Besides factors related to heterogeneity in trial methodology, inter-patient variability and the rare incidence of adult stem cells with intrinsic repair potency underscore the importance of further optimization and standardization of regenerative platforms. Cardiac tissue engineering seizing upon the advances of cellular, molecular, and biomaterial development is shaping the next generation of the regenerative paradigm and thereby fostering disruptive curative treatments in heart failure.
authors.affiliation: Cardiovascular Center, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium. jozef.bartunek@olvz-aalst.be.
authors.forename: Jozef
authors.initials: J
authors.lastname: Bartunek
authors.affiliation: Cardiovascular Center, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Vanderheyden
authors.affiliation: Division of Cardiovascular Diseases, Center for Regenerative Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN, 55902, USA.
authors.forename: Atta
authors.initials: A
authors.lastname: Behfar
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology / Q000637:transplantation; D000818:Animals; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D012038:Regeneration; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds