title: Forty Years of Clathrin-coated Vesicles.
abstract: The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975 was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered the molecular details of clathrin and its associated proteins, including how they assemble into a coated vesicle and how they select cargo. Unexpected connections have been found with signalling, development, neuronal transmission, infection, immunity and genetic disorders. But there are still a number of unanswered questions, including how clathrin-mediated trafficking is regulated and how the machinery evolved.
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Robinson
mesh_terms: D000818:Animals; D003585:Cell Biology / Q000266:history*; D002966:Clathrin / Q000737:chemistry / Q000266:history / Q000378:metabolism; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D021381:Protein Transport
chemical_list: D002966:Clathrin
keywords: adaptin; adaptor; dynamin; endocytosis; sorting signals; trans-Golgi network