title: First report of spumigin production by the toxic Sphaerospermopsis torques-reginae cyanobacterium.
abstract: High resolution mass spectrometry investigation of an extract of the toxic cyanobacterium Sphaerospermopsis torques-reginae ITEP-024 led to the discovery of four new spumigin congeners. The structures for these peptides were postulated on the basis of accurate mass data and isotopic pattern information of both full scan and product ion spectra. This is the first reported evidence of spumigins on Sphaerospermopsis species.
authors.affiliation: School of Pharmaceutical Science, University of São Paulo, Avenida Lineu Prestes 580, Bl 17 05508-900, São Paulo, SP, Brazil.
authors.forename: Miriam
authors.initials: M
authors.lastname: Sanz
authors.affiliation: School of Pharmaceutical Science, University of São Paulo, Avenida Lineu Prestes 580, Bl 17 05508-900, São Paulo, SP, Brazil.
authors.forename: Felipe Augusto
authors.initials: FA
authors.lastname: Dörr
authors.affiliation: School of Pharmaceutical Science, University of São Paulo, Avenida Lineu Prestes 580, Bl 17 05508-900, São Paulo, SP, Brazil. Electronic address: ernani@usp.br.
authors.forename: Ernani
authors.initials: E
authors.lastname: Pinto
mesh_terms: D005591:Chemical Fractionation; D002853:Chromatography, Liquid; D000458:Cyanobacteria / Q000737:chemistry / Q000378:metabolism*; D008387:Marine Toxins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D013058:Mass Spectrometry; D009842:Oligopeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D008387:Marine Toxins; D009842:Oligopeptides
keywords: HPLC-ESI-QTOF-MS; Mass spectrometry; Sphaerospermopsis; Spumigin