title: Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer.
abstract: BACKGROUND
  The aim of this study is to analyze the impact of first degree relative (FDR) of young breast cancer patients.
  
  
  METHODS
  Data were used from our prospective population-based cohort study which started in 1983. The family history (FH) was registered with regard to FDR: the presence or absence of invasive breast cancer in none vs. one or more FDRs at any age.
  
  
  RESULTS
  A total of 1109 women, ≤50 years with 1128 breast conserving treatments was seen. The incidence of FDR was 17.0% for one FDR and 3.2% ≥2 FDR. The three groups, none, 1 or ≥2 FDR, were comparable. The local failure rate is comparable for all three groups. Women with a positive FH and metachronous bilateral breast cancer (MBBC) showed a lower local failure (HR 0.2; 95% CI 0.05-0.8). A positive FH was an independent predictor for a better disease-specific survival (HR 0.6; 95% CI 0.4-0.9).
  
  
  CONCLUSIONS
  A positive FH, based on FDR implies a better prognosis in relation to survival for young women treated with BCT. In contrast to no FH for FDR, MBBC in women with a positive FH was not associated with an increased risk of local recurrence.
authors.affiliation: a Department of Radiation Oncology , Medisch Spectrum Twente , Enschede , The Netherlands .
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Jobsen
authors.affiliation: b Department of Epidemiology , Medisch Spectrum Twente , Enschede , The Netherlands .|c Departement of Research Methodology, Measurement, and Data Analysis , Faculty of Behavioral Science, University of Twente , The Netherlands .
authors.forename: Job
authors.initials: J
authors.lastname: van der Palen
authors.affiliation: d Laboratory for Pathology Oost Nederland , Hengelo , The Netherlands .
authors.forename: Mariël
authors.initials: M
authors.lastname: Brinkhuis
authors.affiliation: a Department of Radiation Oncology , Medisch Spectrum Twente , Enschede , The Netherlands .
authors.forename: Francisca
authors.initials: F
authors.lastname: Ong
authors.affiliation: e Department of Radiation Oncology , Leiden University Medical Centre , Leiden , The Netherlands , and.|f Radiotherapy Centre West, Medical Centre Haaglanden , The Hague , The Netherlands.
authors.forename: Henk
authors.initials: H
authors.lastname: Struikmans
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D010375:Pedigree; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors