title: Brief Report: Prevalence of Latent Rheumatic Heart Disease Among HIV-Infected Children in Kampala, Uganda.
abstract: Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent RHD in 488 HIV-infected children aged 5-18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% confidence interval: 0.26% to 2.23%), which is lower than the published prevalence rates of 1.5%-4% among Ugandan children. There may be protective factors that decrease the risk of RHD in HIV-infected children.
authors.affiliation: *Case Western Reserve University School of Medicine, Cleveland, OH; †University Hospitals Case Medical Center, Cleveland, OH; ‡Joint Clinical Research Center, Kampala, Uganda; §Makerere University School of Medicine, Kampala, Uganda; and ‖Uganda Heart Institute, Kampala, Uganda.
authors.forename: Brigette
authors.initials: B
authors.lastname: Gleason
authors.forename: Grace
authors.initials: G
authors.lastname: Mirembe
authors.forename: Judith
authors.initials: J
authors.lastname: Namuyonga
authors.forename: Emmy
authors.initials: E
authors.lastname: Okello
authors.forename: Peter
authors.initials: P
authors.lastname: Lwabi
authors.forename: Irene
authors.initials: I
authors.lastname: Lubega
authors.forename: Sulaiman
authors.initials: S
authors.lastname: Lubega
authors.forename: Victor
authors.initials: V
authors.lastname: Musiime
authors.forename: Cissy
authors.initials: C
authors.lastname: Kityo
authors.forename: Robert A
authors.initials: RA
authors.lastname: Salata
authors.forename: Chris T
authors.initials: CT
authors.lastname: Longenecker
mesh_terms: D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008297:Male; D015995:Prevalence; D012214:Rheumatic Heart Disease / Q000150:complications / Q000453:epidemiology*; D014454:Uganda / Q000453:epidemiology