title: [Dual antiplatelet therapy and haemoglobin level: An observational study].
abstract: BACKGROUND
  To determine the degree of association between dual antiplatelet therapy (DAPT) (clopidogrel plus acetylsalicylic acid) and haemoglobin (Hb) in clinical practice.
  
  
  METHODS
  A retrospective longitudinal analysis was conducted on all patients on DAPT for at least 6 months. The required sample size was 63 patients. Hb value was determined before DAPT and at least 6 months after, as well as length of treatment, drugs, and diseases that might reduce the Hb. Changes in Hb after DAPT and the emergence or worsening of pre-existing anaemia was determined. Before and after Hb was compared using the t-test for paired samples. The occurrence of anaemia was considered dependent variable in a logistic regression analysis.
  
  
  RESULTS
  A total of 122 cases were included. There were 92 (75.4%) males, and the mean age was 74.5 (SD 9.9) years. DAPT duration was 19.3 (11.8) months. The pre-treatment Hb was 14.3 (1.4) g/dl and 12.8 (1.9) g/dl post-treatment. The prevalence of pre-DAPT anaemia was 9.1% (11 cases), and 45.9% post-treatment (56 cases). Comparison of means showed a decrease of 1.5g/dl (1.6) (95% CI; 1.2-1.8, P<.001). Anaemia post-treatment was associated with concomitant causes of anaemia, bleeding in the follow-up, and inversely with pre-treatment Hb level.
  
  
  CONCLUSIONS
  DAPT is associated with a decrease in Hb. Anaemia or worsening of previous anaemia appeared in about half of the subjects, and this effect was most likely in patients with bleeding in the follow-up and if other causes of anaemia were present.
authors.affiliation: Centro de Salud Ribadavia, Servizo Galego de Saúde (SERGAS), Ribadavia, Ourense, España.
authors.forename: M P
authors.initials: MP
authors.lastname: Quinteiro-Alonso
authors.affiliation: Centro de Salud San Amaro, Servizo Galego de Saúde (SERGAS), San Amaro, Ourense, España.
authors.forename: M
authors.initials: M
authors.lastname: González-Cao
authors.affiliation: Centro de Salud O Carballiño, Servizo Galego de Saúde (SERGAS), O Carballiño, Ourense, España.
authors.forename: C
authors.initials: C
authors.lastname: Barreales-Cardín
authors.affiliation: Centro de Salud Cea, Servizo Galego de Saúde (SERGAS), San Cristovo de Cea, Ourense, España. Electronic address: gabriel.diaz.gravalos@sergas.es.
authors.forename: G J
authors.initials: GJ
authors.lastname: Díaz-Grávalos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D001241:Aspirin / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D000077144:Clopidogrel; D004359:Drug Therapy, Combination; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D015995:Prevalence; D012189:Retrospective Studies; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin
keywords: Anaemia; Anemia; Drug therapy combination; Inhibidores de agregación plaquetaria/efectos adversos; Platelet aggregation inhibitors/adverse effects; Quimioterapia combinada