title: [Risk factors for multidrug-resistant Klebsiella pneumoniae sepsis in children].
abstract: OBJECTIVE
  To explore the risk factors for sepsis caused by multidrug-resistant Klebsiella pneumonia (MDR-KP) and to provide a reference for the prevention of MDR-KP sepsis and rational use of antibiotics.
  
  
  METHODS
  A retrospective case-control study of 41 children with MDR-KP sepsis (case group) and 53 pediatric patients without MDR-KP sepsis (control group) between March 2010 and Febrary 2014 was conducted. Multiple logistic regression analysis was performed to estimate the independent risk factors for MDR-KP sepsis.
  
  
  RESULTS
  Compared with the control group, the case group had a longer length of stay in the PICU before infection (P<0.05), more prolonged duration of mechanical ventilation before infection (P<0.05), a larger total number of days of mechanical ventilation (P<0.05), more days of antibiotic use before infection (P<0.05), more types of antibiotics used before infection (P<0.05), and a higher mortality (P<0.05). The logistic regression analysis showed that more types of antibiotics used before infection and use of third-generation cephalosporin and carbapenems were independent risk factors for MDR-KP sepsis (P<0.05).
  
  
  CONCLUSIONS
  Rational use of antibiotics is an effective measure to prevent MDR-KP sepsis.
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, China. lijj@sj-hospital.org.
authors.forename: Chao
authors.initials: C
authors.lastname: Cheng
authors.forename: Ye-Xin
authors.initials: YX
authors.lastname: Lin
authors.forename: Jiu-Jun
authors.initials: JJ
authors.lastname: Li
authors.forename: Zhi-Jie
authors.initials: ZJ
authors.lastname: Zhang
mesh_terms: D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D007710:Klebsiella Infections / Q000188:drug therapy; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D016015:Logistic Models; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors