title: Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives.
abstract: Metal complexes of the type [Ni(LC)2(X)2], 1 and 2, [Co(LC)2(X)2], 3 and 4 (LC: lidocaine, X = dca (dicyanamide), 1 and 3, X = NCS(-), 2 and 4) have been synthesized and characterized. The geometries of 1-4 were confirmed by single crystal X-ray crystallography. The complexes are water soluble and stable in aqueous solution. The interaction of 1-4 with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) was investigated using UV-visible and fluorescence spectrophotometric methods. A gel electrophoresis assay demonstrated that the complexes cleave pUC19 plasmid DNA. The in vitro free radical scavenging, antimicrobial activity and cytotoxic potential of all the complexes were examined.
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran; School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland.
authors.forename: Leila
authors.initials: L
authors.lastname: Tabrizi
authors.affiliation: School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland. Electronic address: p.mcardle@nuigalway.ie.
authors.forename: Patrick
authors.initials: P
authors.lastname: McArdle
authors.affiliation: School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland. Electronic address: andrea.erxleben@nuigalway.ie.
authors.forename: Andrea
authors.initials: A
authors.lastname: Erxleben
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Chiniforoshan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008012:Lidocaine / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D016166:Free Radical Scavengers; D003035:Cobalt; D009532:Nickel; D008012:Lidocaine
keywords: BSA binding; Cobalt(II) complexes; Cytotoxicity; DNA binding; DNA cleavage; Lidocaine; Nickel(II) complexes