title: STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells.
abstract: STAT4 is a critical mediator of inflammatory immunity and is required for all known IL-12 biological responses, including the induction of IFN-γ and development of Th1 cells. We demonstrate that IL-23, an IL-12-related cytokine, also requires STAT4 for optimal IL-17 secretion from memory T helper cells and NKT cells. Although IL-23 stimulation had modest effects on STAT4 activation, STAT4-deficiency results in reduced Il23r expression. These data demonstrate a restricted requirement for STAT4 in innate and adaptive IL-17-secreting T cell responses that might contribute to inflammatory immunity.
authors.affiliation: Department of Pediatrics; Herman B Wells Center for Pediatric Research ; Indianapolis, IN USA ; Department of Microbiology and Immunology; Indiana University School of Medicine ; Indianapolis, IN USA.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Glosson-Byers
authors.affiliation: Department of Pediatrics; Herman B Wells Center for Pediatric Research ; Indianapolis, IN USA.
authors.forename: Sarita
authors.initials: S
authors.lastname: Sehra
authors.affiliation: Department of Pediatrics; Herman B Wells Center for Pediatric Research ; Indianapolis, IN USA ; Department of Microbiology and Immunology; Indiana University School of Medicine ; Indianapolis, IN USA.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Kaplan
keywords: IL-23R; NKT; STAT4; Th17; memory Th