title: Augmentation cystoplasty: Urodynamic and metabolic outcomes at 10-year follow-up.
abstract: OBJECTIVE
  To review the urodynamic outcomes, renal function and metabolic complications after augmentation cystoplasty with at least 10 years of follow-up.
  
  
  METHODS
  Augmentation cystoplasty performed in two tertiary referral centers from 1995 to 2004 were reviewed. Ten years or more postoperative course was studied by review of the clinical notes, urodynamic reports and laboratory results.
  
  
  RESULTS
  A total of 40 patients were included in this study. The mean age at surgery was 43 years, and 47.5% of patients were female. Median follow up was 13 years. Bladder capacity significantly increased from 283 ± 151 to 492 ± 123 mL (P < 0.01), with a percentage change of +130%. The compliance of the bladder was increased by 87%, and detrusor overactivity decreased by 54.2%. There were no significant changes in preoperative and postoperative estimated glomerular filtration rate (68.3 mL/min vs. 76.6 mL/min, P = 0.798). Three patients (7.5%) had more than one episode of symptomatic urinary tract infection per year.
  
  
  CONCLUSIONS
  The present study confirms the effectiveness of augmentation cystoplasty in increasing bladder capacity, improving bladder compliance and reducing detrusor overactivity. The preservation of renal function and low metabolic complication rate provide solid evidence for carrying out this time-honored procedure in patients with neurogenic or non-neurogenic bladder dysfunction.
authors.affiliation: Division of Urology, Department of Surgery, Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: Kwun-Chung
authors.initials: KC
authors.lastname: Cheng
authors.affiliation: Division of Urology, Department of Surgery, Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: Chi-Fai
authors.initials: CF
authors.lastname: Kan
authors.affiliation: Division of Urology, Department of Surgery, Tuen Mun Hospital, New Territories, Hong Kong.
authors.forename: Peggy Sau-Kwan
authors.initials: PS
authors.lastname: Chu
authors.affiliation: Division of Urology, Department of Surgery, Tuen Mun Hospital, New Territories, Hong Kong.
authors.forename: Chi-Wai
authors.initials: CW
authors.lastname: Man
authors.affiliation: Pedder Clinic, Central, Hong Kong.
authors.forename: Bill Tak-Hing
authors.initials: BT
authors.lastname: Wong
authors.affiliation: Division of Urology, Department of Surgery, Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: Lap-Yin
authors.initials: LY
authors.lastname: Ho
authors.affiliation: Division of Urology, Department of Surgery, Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: Wing-Hang
authors.initials: WH
authors.lastname: Au
mesh_terms: D000138:Acidosis / Q000188:drug therapy / Q000209:etiology*; D000328:Adult; D003106:Colon / Q000637:transplantation; D003187:Compliance; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007082:Ileum / Q000637:transplantation; D007669:Kidney Calculi / Q000209:etiology*; D008297:Male; D009929:Organ Size; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies; D013270:Stomach / Q000637:transplantation; D001743:Urinary Bladder / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D001750:Urinary Bladder, Neurogenic / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D053201:Urinary Bladder, Overactive / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D014552:Urinary Tract Infections / Q000209:etiology*; D014563:Urodynamics
keywords: bladder augmentation; enterocystoplasty; urinary bladder, neurogenic; urinary bladder, overactive