title: Patient Psoas Muscle Mass as a Predictor of Complications and Survival After Radical Cystectomy.
abstract: As a treatment for high-risk bladder cancer, radical cystectomy (RC) remains a highly morbid operation with complication rates of 40-60% and mortality rates as high as 9% in the first 90 days after surgery (Aziz et al., Eur Urol 66(1):156-163, 2014; Shabsigh et al., Eur Urol 55(1):164-174, 2009). Many patients suffer from a failure-to-thrive syndrome associated with anorexia, weight loss, dehydration, and immobility. In elderly patients, failure-to-thrive may result in loss of independence and a cascade of events that increases the risk of perioperative morbidity and mortality, ultimately resulting in impaired survival. Psoas muscle mass has been used to predict morbidity and mortality after major surgical procedures in vulnerable populations with substantial comorbidities. Increasingly, psoas muscle mass is also being used to predict outcomes after RC. If patients with a high risk of impaired survival are identified preoperatively, prehabilitative interventions can be integrated into their preparation for surgical treatment (Porserud et al., Clin Rehab 28(5):451-459, 2014; Friedman et al., Nutr Clin Pract: Off Publ Am Soc Parenter Enter Nutr 30(2):175-179, 2015). This chapter discusses the role of psoas muscle mass as a predictor of negative surgical outcomes after cystectomy.
authors.affiliation: Oregon Health and Science University, Portland, OR, USA. hamd.ahmd@gmail.com.
authors.forename: Hamed
authors.initials: H
authors.lastname: Ahmadi
authors.affiliation: University of Michigan, 7303 CCGC, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109-5946, USA. jmontie@umich.edu.
authors.forename: James E
authors.initials: JE
authors.lastname: Montie
authors.affiliation: University of Michigan, 7303 CCGC, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109-5946, USA. aweizer@med.umich.edu.
authors.forename: Alon Z
authors.initials: AZ
authors.lastname: Weizer
authors.affiliation: University of Michigan, 7303 CCGC, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109-5946, USA. tomorgan@med.umich.edu.
authors.forename: Todd
authors.initials: T
authors.lastname: Morgan
authors.affiliation: University of Michigan, 7303 CCGC, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109-5946, USA. montrose@med.umich.edu.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Montgomery
authors.affiliation: University of Michigan, 7303 CCGC, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109-5946, USA. ctlee@umich.edu.
authors.forename: Cheryl T
authors.initials: CT
authors.lastname: Lee
mesh_terms: D015653:Cystectomy / Q000009:adverse effects*; D006801:Humans; D011183:Postoperative Complications / Q000453:epidemiology; D016658:Psoas Muscles; D055948:Sarcopenia / Q000628:therapy; D016896:Treatment Outcome
keywords: Complications; Morphomics; Psoas area; Radical cystectomy; Sarcopenia; Survival