title: A novel delivery platform based on Bacteriophage MS2 virus-like particles.
abstract: Our objective here is to review the novel delivery platform based on Bacteriophage MS2 virus-like particles (VLPs), including introduction to their structure, their potential as a delivery platform, and their expected use in medicine and other fields. Bacteriophage MS2 VLPs are nanoparticles devoid of viral genetic material and can self-assemble from the coat protein into an icosahedral capsid. As a novel delivery platform, they possess numerous features that make them suitable and attractive for targeted delivery of RNAs or DNAs, epitope peptides, and drugs within the protein capsid. In short, as a novel delivery platform, MS2 VLPs are suitable for delivery of targeted agents and hold promise for use in diagnostics, vaccines, and therapeutic modalities.
authors.affiliation: National Center for Clinical Laboratories, Beijing Hospital, Beijing 100029, China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China; Departments of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.affiliation: National Center for Clinical Laboratories, Beijing Hospital, Beijing 100029, China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China. Electronic address: jmli63hn@gmail.com.
authors.forename: Jinming
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques; D006801:Humans; D017909:Levivirus / Q000235:genetics* / Q000502:physiology; D014771:Virion / Q000235:genetics* / Q000502:physiology; D019065:Virus Assembly
keywords: Bacteriophage MS2; Delivery platform; In vitro diagnostic; Therapy; Vaccine; Virus-like particles