title: Hippocampome.org: a knowledge base of neuron types in the rodent hippocampus.
abstract: Hippocampome.org is a comprehensive knowledge base of neuron types in the rodent hippocampal formation (dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex). Although the hippocampal literature is remarkably information-rich, neuron properties are often reported with incompletely defined and notoriously inconsistent terminology, creating a formidable challenge for data integration. Our extensive literature mining and data reconciliation identified 122 neuron types based on neurotransmitter, axonal and dendritic patterns, synaptic specificity, electrophysiology, and molecular biomarkers. All ∼3700 annotated properties are individually supported by specific evidence (∼14,000 pieces) in peer-reviewed publications. Systematic analysis of this unprecedented amount of machine-readable information reveals novel correlations among neuron types and properties, the potential connectivity of the full hippocampal circuitry, and outstanding knowledge gaps. User-friendly browsing and online querying of Hippocampome.org may aid design and interpretation of both experiments and simulations. This powerful, simple, and extensible neuron classification endeavor is unique in its detail, utility, and completeness.
authors.affiliation: Krasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
authors.forename: Diek W
authors.identifier: http://orcid.org/0000-0001-8635-0033
authors.initials: DW
authors.lastname: Wheeler
authors.affiliation: Krasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
authors.forename: Charise M
authors.initials: CM
authors.lastname: White
authors.affiliation: Krasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Rees
authors.affiliation: Krasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Komendantov
authors.affiliation: Krasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
authors.forename: David J
authors.identifier: http://orcid.org/0000-0001-6265-9917
authors.initials: DJ
authors.lastname: Hamilton
authors.affiliation: Krasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
authors.forename: Giorgio A
authors.initials: GA
authors.lastname: Ascoli
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000166:cytology*; D016247:Information Storage and Retrieval; D051188:Knowledge Bases; D009474:Neurons / Q000145:classification*; D012377:Rodentia
keywords: dentate gyrus; entorhinal cortex; literature mining; mouse; neural circuit; neuronal classification; neuroscience; potential connectome; rat