title: Significance of obstructive sleep apnea in the patient with pulmonary hypertension.
abstract: OBJECTIVE
  The purpose of this review was to evaluate the consequence of obstructive sleep apnea (OSA) in pulmonary hypertension by reviewing the current literature and understanding potential pathophysiological mechanisms.
  
  
  RESULTS
  Small studies have suggested a high prevalence of comorbid OSA in those with known pulmonary hypertension. Pathophysiological mechanisms are highly suggestive of potential deleterious effect of OSA on pulmonary hemodynamics.
  
  
  CONCLUSIONS
  Clearly, current research work on comorbid OSA and pulmonary hypertension is still in its infancy and the field is ripe for future investigation. The significance of OSA in this population has yet to be fully determined.
authors.affiliation: aSleep Research Laboratory, University Health Network/Toronto Rehabilitation Institute bDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Milan
authors.initials: M
authors.lastname: Minic
authors.forename: Clodagh M
authors.initials: CM
authors.lastname: Ryan
mesh_terms: D000818:Animals; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000503:physiopathology*; D015995:Prevalence; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology*