title: Advanced therapies of skin injuries.
abstract: The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.
authors.affiliation: Faculty of Mechanical Engineering, Laboratory for Characterisation and Processing of Polymers, University of Maribor, Smetanova 17, 2000, Maribor, Slovenia.
authors.forename: Tina
authors.initials: T
authors.lastname: Maver
authors.affiliation: Faculty of Medicine, Department of Pharmacology and Experimental Toxicology, University of Maribor, Taborska ulica 8, 2000, Maribor, Slovenia. uros.maver@um.si.
authors.forename: Uroš
authors.initials: U
authors.lastname: Maver
authors.affiliation: Faculty of Mechanical Engineering, Laboratory for Characterisation and Processing of Polymers, University of Maribor, Smetanova 17, 2000, Maribor, Slovenia.
authors.forename: Karin Stana
authors.initials: KS
authors.lastname: Kleinschek
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia.
authors.forename: Irena Mlinarič
authors.initials: IM
authors.lastname: Raščan
authors.affiliation: University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Dragica Maja
authors.initials: DM
authors.lastname: Smrke
mesh_terms: D001458:Bandages; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D022125:Lacerations / Q000175:diagnosis / Q000628:therapy*; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D012867:Skin / Q000293:injuries*; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial
keywords: Allograft; Autograft; Scaffold; Tissue engineering; Tissue-engineered skin