title: Pathogenesis and Cerebrospinal Fluid Hydrodynamics of the Chiari I Malformation.
abstract: This article summarizes the current understanding of the pathophysiology of the Chiari I malformation that is based on observations of the anatomy visualized by modern imaging with MRI and prospective studies of the physiology of patients before and after surgery. The pathogenesis of a Chiari I malformation of the cerebellar tonsils is grouped into 4 general mechanisms.
authors.affiliation: Department of Neurological Surgery, University of Virginia Health System, P.O. Box 800212, Charlottesville, VA 22908, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Buell
authors.affiliation: Surgical Neurology Branch, National Institutes of Health, 10 Center Drive, 10/3D20, MSC-1414, Bethesda, MD 20892, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Heiss
authors.affiliation: Department of Neurological Surgery, University of Virginia Health System, P.O. Box 800212, Charlottesville, VA 22908, USA. Electronic address: EHO4U@hscmail.mcc.virginia.edu.
authors.forename: Edward H
authors.initials: EH
authors.lastname: Oldfield
mesh_terms: D001139:Arnold-Chiari Malformation / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D002555:Cerebrospinal Fluid; D003388:Cranial Fossa, Posterior / Q000473:pathology / Q000601:surgery*; D006801:Humans; D057446:Hydrodynamics; D008279:Magnetic Resonance Imaging / Q000379:methods; D012886:Skull / Q000601:surgery
keywords: Chiari I malformation; Hydrocephalus; Posterior fossa