title: Pulmonary Sporotrichosis: An Evolving Clinical Paradigm.
abstract: In recent decades, sporotrichosis, caused by thermally dimorphic fungi Sporothrix schenckii complex, has become an emerging infection in many parts of the world. Pulmonary infection with S. schenckii still remains relatively uncommon, possibly due to underrecognition. Pulmonary sporotrichosis presents with distinct clinical and radiological patterns in both immunocompetent and immunocompromised hosts and can often result in significant morbidity and mortality despite treatment. Current understanding regarding S. schenckii biology, epidemiology, immunopathology, clinical diagnostics, and treatment options has been evolving in the recent years with increased availability of molecular sequencing techniques. However, this changing knowledge has not yet been fully translated into a better understanding of the clinical aspects of pulmonary sporotrichosis, as such current management guidelines remain unsupported by high-level clinical evidence. This article examines recent advances in the knowledge of sporotrichosis and its application to the difficult challenges of managing pulmonary sporotrichosis.
authors.affiliation: Department of General Medicine, The Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: Ar K
authors.initials: AK
authors.lastname: Aung
authors.affiliation: Department of Infectious Diseases, The Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: Denis W
authors.initials: DW
authors.lastname: Spelman
authors.affiliation: The Lung Health Clinic, Hollywood Hospital and the Sir Charles Gairdner Hospital Nedlands, and The School of Medicine and Pharmacology University of Western Australia, Perth, WA, Australia.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Thompson
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D019468:Disease Management; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000382:microbiology*; D011859:Radiography; D012307:Risk Factors; D013175:Sporothrix; D013174:Sporotrichosis / Q000175:diagnosis* / Q000453:epidemiology*
chemical_list: D000935:Antifungal Agents