title: Liquisolid technology: What it can do for NSAIDs delivery?
abstract: Liquisolid technology is also known as powder solution technology and is the technique which deals with the solubility term. This technology has been used to modify the dissolution rate of many drugs. Using this technique, many drugs exhibited enhanced or retarded dissolution rate. Non-steroidal anti-inflammatory drugs are among the highly important medications whose bioavailability is affected by the lower dissolution rate. In order to enhance the dissolution rate and subsequently the bioavailability of some of these drugs, liquisolid technology was used. This study reviewed the application of this useful technique for enhancing the dissolution rate of these important drugs and also the obtained results have been discussed in more details.
authors.affiliation: Drug Applied Research Centre and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Azharshekoufeh B
authors.affiliation: Biotechnology Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Shokri
authors.affiliation: Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran.
authors.forename: Khosro
authors.initials: K
authors.lastname: Adibkia
authors.affiliation: Drug Applied Research Centre and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran; Biotechnology Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran. Electronic address: javadzadehy@yahoo.com.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Javadzadeh
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D016503:Drug Delivery Systems; D033362:Powder Diffraction; D012995:Solubility
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Bioavailability; Dissolution rate; Liquisolid; NSAIDs