title: New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer.
abstract: Although the profile of safety of tumor-targeted oncolytic virus (TOV) is encouraging, the antitumor efficacy of TOV alone is disappointing. Interleukin-10 (IL-10) plays an important role in carcinogenesis and anti-virus immunity. Here we report that tumor-targeted oncolytic vaccinia virus (VV) armed with IL10 shows promising potential for treatment of pancreatic cancer (PaCa).
authors.affiliation: Center for Molecular Oncology; Barts Cancer Institute; Queen Mary University of London ; London, UK.
authors.forename: Louisa S
authors.initials: LS
authors.lastname: Chard
authors.affiliation: Center for Molecular Oncology; Barts Cancer Institute; Queen Mary University of London ; London, UK ; Sino-British Research Centre for Molecular Oncology; National Centre for International Research in Cell and Gene Therapy; Zhengzhou University ; Zhengzhou, China.
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Lemoine
authors.affiliation: Center for Molecular Oncology; Barts Cancer Institute; Queen Mary University of London ; London, UK ; Sino-British Research Centre for Molecular Oncology; National Centre for International Research in Cell and Gene Therapy; Zhengzhou University ; Zhengzhou, China.
authors.forename: Yaohe
authors.initials: Y
authors.lastname: Wang
keywords: IL-10; immunotherapy; oncolytic virus; pancreatic cancer; vaccinia virus