title: Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103-and XCR1+CD103+dendritic cells.
abstract: The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered. We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melanoma model where tumor establishment and expansion is within the skin. Two migratory populations defined as CD103-XCR1+and CD103+XCR1+efficiently cross-presented melanoma-derived antigen, with the CD103-XCR1+DCs surprisingly dominating this process. These results are critical for understanding how antitumor CD8+T cell immunity is coordinated to tumor antigens present within the skin.
authors.affiliation: Telethon Kids Institute; University of Western Australia ; Subiaco, Australia.
authors.forename: Ben
authors.initials: B
authors.lastname: Wylie
authors.affiliation: Telethon Kids Institute; University of Western Australia ; Subiaco, Australia.
authors.forename: Elke
authors.initials: E
authors.lastname: Seppanen
authors.affiliation: T cell Laboratory; School of Molecular Science; La Trobe University ; Bundoora, Victoria, Australia.
authors.forename: Kun
authors.initials: K
authors.lastname: Xiao
authors.affiliation: Telethon Kids Institute; University of Western Australia ; Subiaco, Australia.
authors.forename: Rachael
authors.initials: R
authors.lastname: Zemek
authors.affiliation: T cell Laboratory; School of Molecular Science; La Trobe University ; Bundoora, Victoria, Australia.
authors.forename: Damien
authors.initials: D
authors.lastname: Zanker
authors.affiliation: CSL Limited; Bio21 Institute ; Parkville, Victoria, Australia.
authors.forename: Sandro
authors.initials: S
authors.lastname: Prato
authors.affiliation: Telethon Kids Institute; University of Western Australia ; Subiaco, Australia.
authors.forename: Bree
authors.initials: B
authors.lastname: Foley
authors.affiliation: Telethon Kids Institute; University of Western Australia ; Subiaco, Australia.
authors.forename: Prue H
authors.initials: PH
authors.lastname: Hart
authors.affiliation: Molecular Immunology; Robert Koch Institute ; Berlin, Germany.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Kroczek
authors.affiliation: T cell Laboratory; School of Molecular Science; La Trobe University ; Bundoora, Victoria, Australia.
authors.forename: Weisan
authors.initials: W
authors.lastname: Chen
authors.affiliation: Telethon Kids Institute; University of Western Australia ; Subiaco, Australia.
authors.forename: Jason
authors.initials: J
authors.lastname: Waithman
keywords: Cancer; cross-presentation; dendritic cells; melanoma; tumor immunity