title: Research progress in physicochemical characteristics of lactoferrin and its recombinant expression systems.
abstract: Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80 kDa that belongs to the transferrin family. Due to its unique physical and chemical properties, lactoferrin has a variety of biological functions including antibacterial, antiviral, anticancer, immunomodulatory activities and regulation of iron absorption. High-yield production of recombinant lactoferrin with biological activity and its application in clinical treatment have been a hot topic for long time. With the development of genetic engineering techniques, various expression systems have been developed to produce recombinant lactoferrin. In this review, we summarize physicochemical characteristics, biological activities, clinical studies and current recombinant expression systems of lactoferrin, in order to provide references for its clinical application.
authors.affiliation: 1. State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin 300071, China; 2. Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071, China;
authors.forename: Xiao-nan
authors.initials: XN
authors.lastname: Pang
authors.affiliation: Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hong
authors.affiliation: Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
authors.forename: Xi-wen
authors.initials: XW
authors.lastname: Chen
authors.affiliation: Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1. State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin 300071, China; 2. Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071, China;
authors.forename: De-fu
authors.initials: DF
authors.lastname: Chen
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D004926:Escherichia coli / Q000235:genetics; D005658:Fungi / Q000235:genetics; D005818:Genetic Engineering; D006031:Glycosylation; D006801:Humans; D007781:Lactoferrin / Q000737:chemistry* / Q000502:physiology*; D030821:Plants, Genetically Modified / Q000235:genetics; D011994:Recombinant Proteins / Q000096:biosynthesis*
chemical_list: D011994:Recombinant Proteins; D007781:Lactoferrin