title: Cytotoxic and Antimalarial Alkaloids from the Twigs of Dasymaschalon obtusipetalum.
abstract: One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC50 values of 2.46 ± 0.12 and 1.38 ± 0.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity.
authors.forename: Atchara
authors.initials: A
authors.lastname: Jaidee
authors.forename: Thanika
authors.initials: T
authors.lastname: Promchai
authors.forename: Kongkiat
authors.initials: K
authors.lastname: Trisuwan
authors.forename: Surat
authors.initials: S
authors.lastname: Laphookhieo
authors.forename: Roonglawan
authors.initials: R
authors.lastname: Rattanajak
authors.forename: Sumalee
authors.initials: S
authors.lastname: Kamchonwongpaisan
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Pyne
authors.forename: Thunwadee
authors.initials: T
authors.lastname: Ritthiwigrom
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D014709:Vero Cells
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic