title: Predictors of intestinal pseudo-obstruction in systemic lupus erythematosus complicated by digestive manifestations: data from a Southern China lupus cohort.
abstract: OBJECTIVE
  To determine factors that may predict intestinal pseudo-obstruction (IpsO) in systemic lupus erythematosus (SLE) patients complicated by digestive manifestations.
  
  
  METHODS
  SLE patients with digestive manifestations (n = 135) were followed at Southern Medical University affiliated Nanfang Hospital from 2000 until 2013. Demographic variables, clinical features, and laboratory data were compared between the two groups. Univariate and multivariate logistic regression models were used to establish factors that predispose to IpsO in these patients.
  
  
  RESULTS
  At the end of the study period, 32 (23.7%) patients had developed IpsO. Mortality (9 patients) was infrequent and the cause of death was unrelated to IpsO. Independent predictors of IpsO in SLE were ureterectasia, anti-U1 RNP(+), peritonitis, and low C3 levels.
  
  
  CONCLUSIONS
  Regular abdominal X-ray examinations are recommended in SLE patients with ureterectasia, anti-U1 RNP(+), peritonitis, or low C3 levels, as early diagnosis and therapy may prevent unnecessary surgical intervention and improve the disease course.
authors.affiliation: Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: W
authors.initials: W
authors.lastname: Lai
authors.affiliation: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: C
authors.initials: C
authors.lastname: Yuan
authors.affiliation: School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.
authors.forename: S
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: D
authors.initials: D
authors.lastname: Cui
authors.affiliation: Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Ren
authors.affiliation: Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China minyanggz@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Yang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002423:Cause of Death; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003176:Complement C3 / Q000032:analysis; D004066:Digestive System Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D004108:Dilatation, Pathologic; D015536:Down-Regulation; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D016015:Logistic Models; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010538:Peritonitis / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014513:Ureter / Q000473:pathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; C038245:C3 protein, human; D003176:Complement C3
keywords: Systemic lupus erythematosus; digestive manifestations; intestinal pseudo-obstruction; logistic regression; predictor