title: Observation of sound-induced corneal vibrational modes by optical coherence tomography.
abstract: The mechanical stability of the cornea is critical for maintaining its normal shape and refractive function. Here, we report an observation of the mechanical resonance modes of the cornea excited by sound waves and detected by using phase-sensitive optical coherence tomography. The cornea in bovine eye globes exhibited three resonance modes in a frequency range of 50-400 Hz. The vibration amplitude of the fundamental mode at 80-120 Hz was ~8 µm at a sound pressure level of 100 dB (2 Pa). Vibrography allows the visualization of the radially symmetric profiles of the resonance modes. A dynamic finite-element analysis supports our observation.
authors.affiliation: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, 40 Blossom St., Boston, MA, 02140, USA.
authors.forename: B Imran
authors.initials: BI
authors.lastname: Akca
authors.affiliation: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, 40 Blossom St., Boston, MA, 02140, USA.
authors.forename: Ernest W
authors.initials: EW
authors.lastname: Chang
authors.affiliation: Instituto de Óptica, Consejo Superior de Investigaciónes Cientificas, Madrid, Spain.
authors.forename: Sabine
authors.initials: S
authors.lastname: Kling
authors.affiliation: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, 40 Blossom St., Boston, MA, 02140, USA ; The Harvard-MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
authors.forename: Antoine
authors.initials: A
authors.lastname: Ramier
authors.affiliation: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, 40 Blossom St., Boston, MA, 02140, USA ; Department of Bioengineering, 2217 Jeong H. Kim Engineering Building, University of Maryland, College Park, MD, 20742, USA.
authors.forename: Giuliano
authors.initials: G
authors.lastname: Scarcelli
authors.affiliation: Instituto de Óptica, Consejo Superior de Investigaciónes Cientificas, Madrid, Spain ; susana@io.cfmac.csic.es.
authors.forename: Susana
authors.initials: S
authors.lastname: Marcos
authors.affiliation: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, 40 Blossom St., Boston, MA, 02140, USA.
authors.forename: Seok H
authors.initials: SH
authors.lastname: Yun
keywords: (100.3010) Image reconstruction techniques; (170.4470) Ophthalmology; (170.4500) Optical coherence tomography