title: Deferasirox-induced serious adverse reaction in a pediatric patient: pharmacokinetic and pharmacogenetic analysis.
authors.affiliation: DEA Intensive Care Unit, IRCCS "Bambino Gesù" Children Hospital, Piazza S. Onofrio 4, Rome, 00165, Italy. marco.marano@opbg.net.
authors.forename: M
authors.initials: M
authors.lastname: Marano
authors.affiliation: Department of Pediatrics "Tor Vergata University", Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bottaro
authors.affiliation: Laboratory of Analytical Biochemistry, IRCCS "Bambino Gesù" Children Hospital, Rome, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Goffredo
authors.affiliation: DEA Intensive Care Unit, IRCCS "Bambino Gesù" Children Hospital, Piazza S. Onofrio 4, Rome, 00165, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Stoppa
authors.affiliation: DEA, IRCCS "Bambino Gesù" Children Hospital, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pisani
authors.affiliation: Department of Pediatrics, Section of Pediatrics Haematology and Oncology, University of Sassari, Sassari, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Marinaro
authors.affiliation: Department of Pediatric Medicine, Division of Metabolism, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Deodato
authors.affiliation: Department of Pediatric Medicine, Division of Metabolism, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Dionisi-Vici
authors.affiliation: Scientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy.|Department of Biomedical and Clinical Sciences L. Sacco, Unit of Clinical Pharmacology, CNR Institute of Neuroscience, "Luigi Sacco" University Hospital, University of Milano, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Clementi
authors.affiliation: Department of Biomedical and Clinical Sciences, Unit of Clinical Pharmacology, "Luigi Sacco" University Hospital, University of Milano, Milan, Italy.
authors.forename: F S
authors.initials: FS
authors.lastname: Falvella
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D001565:Benzoates / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D002675:Child, Preschool; D000077588:Deferasirox; D005260:Female; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D007502:Iron Chelating Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D013789:Thalassemia / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D014230:Triazoles / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D000099148:UGT1A1 Enzyme
chemical_list: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D001565:Benzoates; D000077588:Deferasirox; D014453:Glucuronosyltransferase; D007502:Iron Chelating Agents; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009363:Neoplasm Proteins; D014230:Triazoles; D000099148:UGT1A1 Enzyme; C116614:ABCG2 protein, human
keywords: Adverse events; Deferasirox; Hyperammonemia; Hyperchloremic metabolic acidosis