title: Association between polymorphisms of the CRH and POMC genes with economic traits in Korean cattle (Hanwoo).
abstract: The corticotrophin-releasing hormone (CRH) and proo-piomelanocortin (POMC) genes are considered to play an important role in the growth and development of mammals. In this study, the bovine CRH and POMC genes were characterized to detect genetic variation at these loci in relation to economic traits in Korean cattle (Hanwoo). Nine single nucleotide polymorphisms (SNPs; C148T, A186G, A234C, G269A, G1030A, G1084A, A1136C, G1179C, and A1439G) were detected in the CRH gene, and six SNPs (C7017T, A7027T, C7050T, G7063T, C7160T, and C7221T) were detected in the POMC gene. Three SNPs in the CRH gene (G1030A, G1084A, and G1179C) were missense mutations, and three SNPs in the POMC gene (C7017T, A7027T, and C7160T) were missense mutations. Statistical analysis indicated that one CRH polymorphism (G1084A) was signifi-cantly (P = 0.05) associated with the longissimus dorsi muscle area (LMA), and a POMC polymorphism (C7221T) significantly influenced LMA and marbling scores. A significant interaction was detected be-tween CRH and POMC in relation to carcass weight and LMA. These results indicate that CRH and POMC may be candidate genes for car-cass traits, and suggest that the interaction between CRH and POMC strongly affects carcass traits in cattle.
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Seong
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong, Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Kong
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics; D001947:Breeding; D002417:Cattle; D003346:Corticotropin-Releasing Hormone / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D056726:Genetic Association Studies; D005838:Genotype; D008297:Male; D008460:Meat; D018482:Muscle, Skeletal / Q000378:metabolism; D020125:Mutation, Missense; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011333:Pro-Opiomelanocortin / Q000235:genetics*; D019655:Quantitative Trait, Heritable
chemical_list: D011333:Pro-Opiomelanocortin; D003346:Corticotropin-Releasing Hormone