title: Intestine-Specific Delivery of Hydrophobic Bioactives from Oxidized Starch Microspheres with an Enhanced Stability.
abstract: An intestine-specific delivery system for hydrophobic bioactives with improved stability was developed. It consists of oxidized potato starch polymers, where the carboxyl groups were physically cross-linked via ferric ions. The model hydrophobic ingredients (β-carotene) were incorporated inside the starch microspheres via a double-emulsion method. Confocal laser scanning microscopy images showed that β-carotene were distributed homogeneously in the inner oil phase of the starch microspheres. The negative value of the ζ-potential of microspheres increased with increasing pH and decreasing ionic strength. In vitro release experiments showed that the microspheres were stable at acidic stomach conditions (pH < 2), whereas at neutral intestinal conditions (pH 7.0), they rupture to release the loaded β-carotene. The 1,1-diphenyl-2-picrylhydrazyl radical, 2,2-diphenyl-1-(2,4,6-trinitriphenyl), scavenging activity results suggested that microsphere-encapsulated β-carotene had an improved activity after thermal treatment at 80 °C. The storage stability of encapsulated β-carotene at room temperature was also enhanced. The starch microspheres showed potential as intestine-specific carriers with an enhanced stability.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Mengxuan
authors.initials: M
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Jiande
authors.initials: J
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Xianwu
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Zuseng
authors.initials: Z
authors.lastname: Li
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Qipeng
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology , Post Office Box 53, Beijing 100029, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007422:Intestines / Q000187:drug effects*; D008863:Microspheres; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D010316:Particle Size; D010936:Plant Extracts / Q000737:chemistry; D011198:Solanum tuberosum / Q000737:chemistry; D013213:Starch / Q000737:chemistry*; D019207:beta Carotene / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D010936:Plant Extracts; D019207:beta Carotene; D013213:Starch
keywords: encapsulation; microspheres; oxidized potato starch polymer; stability; β-carotene