title: Stereotactic body radiotherapy for head and neck cancer: an addition to the armamentarium against head and neck cancer.
abstract: In the recent years, stereotactic body radiation therapy (SBRT) has emerged as a potential therapy for head and neck malignancies. Although early results appear to be promising, serious acute and late effects have been observed, mainly in patients who have had prior external beam radiotherapy. This review will discuss the radiobiology of SBRT, clinical rationale and outcomes for SBRT in head and neck cancers and focus on the benefits and potential limitations in both de novo and re-irradiation settings.
authors.affiliation: Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
authors.forename: Irene
authors.initials: I
authors.lastname: Karam
authors.affiliation: Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
authors.forename: Ian
authors.initials: I
authors.lastname: Poon
authors.affiliation: Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
authors.forename: Justin
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
authors.forename: Stanley
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Otolaryngology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
authors.forename: Kevin
authors.initials: K
authors.lastname: Higgins
authors.affiliation: Department of Otolaryngology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
authors.forename: Danny
authors.initials: D
authors.lastname: Enepekides
authors.affiliation: Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
authors.forename: Arjun
authors.initials: A
authors.lastname: Sahgal
authors.affiliation: Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, 11100 Euclid Avenue, LTR B181, Cleveland, OH, USA.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Lo
mesh_terms: D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D006801:Humans; D009367:Neoplasm Staging; D019106:Postoperative Hemorrhage / Q000209:etiology; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods; D019233:Retreatment / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome
keywords: carotid blowout; head and neck cancer; local control; overall survival; radiobiology; re-irradiation; stereotactic body radiotherapy; toxicity