title: Role of the Timed Up and Go Test in Patients With Chronic Obstructive Pulmonary Disease.
abstract: OBJECTIVE
  The Timed Up and Go (TUG) test is a measure of functional mobility. It is a short test and requires minimal space. We determined the potential role of TUG test as a measure of function in patients with chronic obstructive pulmonary disease (COPD) and compared with controls. Furthermore, we wanted to determine the association and reliability of TUG test time to fall history.
  
  
  METHODS
  Patients with COPD (n = 119) and controls with a smoking history (n = 58) were recruited. The TUG test, 6-minute walk distance and subsequent BODE score, spirometry, and history of falls were assessed. The TUG test was measured across observers and on separate days within the same individual.
  
  
  RESULTS
  The TUG test time was greater in patients, 11.9 ± 3.7 seconds, than controls, 9.5 ± 1.8 seconds (P < .001). The TUG test was inversely related to 6-minute walk distance in patients (r =-0.74) and controls (r =-0.71); P < .001. In patients, TUG test was related to BODE score (r = 0.53; P < .001) but not spirometry measurements. A receiver operator curve analysis of 0.77 in patients indicated reasonable ability for TUG test to indicate those who had fallen in the past year. A TUG of ≥12 seconds had 74% sensitivity and specificity for a history of a fall in the past year. Inter- and intraobserver values indicated minimal differences between measurements.
  
  
  CONCLUSIONS
  These results support a potential role for the TUG test to be incorporated into community COPD assessment to stratify patients functionally, particularly where time and space are limited. Future studies are required to assess impact of interventions on TUG test and determine the predictive ability to identify future falls.
authors.affiliation: Nottingham Respiratory Research Unit, School of Medicine, University of Nottingham (Mr Al Haddad and Drs John and Bolton), and Nottingham Respiratory Research Unit, City Hospital, NUH Trust (Drs John and Bolton and Ms Hussain), Nottingham, United Kingdom.
authors.forename: Maath A
authors.initials: MA
authors.lastname: Al Haddad
authors.forename: Michelle
authors.initials: M
authors.lastname: John
authors.forename: Samia
authors.initials: S
authors.lastname: Hussain
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: Bolton
mesh_terms: D000058:Accidental Falls; D000368:Aged; D004185:Disability Evaluation; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012372:ROC Curve; D015203:Reproducibility of Results; D013147:Spirometry; D016138:Walking / Q000502:physiology