title: [The effects of Shadu Cao Mixture on immune functions of immunosuppression mice].
abstract: OBJECTIVE
  To investigate the effects of Shadu Cao Mixture (SDCM, traditional Chinese medicine) on immune functions of immunosuppression mice.
  
  
  METHODS
  Fifty BALB/C mice were randomly divided into blank control group, model group, SDCM low-dose, middle-dose and high-dose group. Except the blank control group, other groups were intraperitoneal injected with cyclophosphamide (40 mg/kg) to establish immunosuppression mice model. The blank control group and model group received gavage administration with nonnal saline, while the other groups received gavage administration with different doses of SDCM (10, 20, 40 m/kg for 15 days) respectively. The number of leukocytes and serum levels of interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood, spleen index, and the function of NK cells were measured.
  
  
  RESULTS
  Compared with the model group , SDCM increased the number of leukocytes and serum concentrations of IL-2, TNF-α and IFN-γ in peripheral blood and improved the spleen index and the function of NK cells significantly (P < 0.05-0.01).
  
  
  CONCLUSIONS
  SDCM could remarkably enhance the immune functions of immunosuppression mice induced by cyclophosphamide.
authors.forename: Shun-fei
authors.initials: SF
authors.lastname: Lu
authors.forename: Liang-liang
authors.initials: LL
authors.lastname: Wang
authors.forename: Jun-wan
authors.initials: JW
authors.lastname: Lu
authors.forename: Bing-jin
authors.initials: BJ
authors.lastname: Liu
authors.forename: Ying-peng
authors.initials: YP
authors.lastname: Tong
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Cheng
authors.forename: Ting-mei
authors.initials: TM
authors.lastname: Ye
mesh_terms: D000818:Animals; D003520:Cyclophosphamide; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007165:Immunosuppression Therapy; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D003520:Cyclophosphamide