title: Progressive supranuclear palsy and Parkinson's disease overlap: A clinicopathological case report.
abstract: We describe a woman with a 13-year history of postural instability, vertical gaze palsy and dopa-responsive parkinsonism - a clinical profile that corresponds to progressive supranuclear palsy (PSP) and Parkinson's disease (PD). The patient died at the age of 82 years. Neuropathological features included neuronal loss and gliosis in the substantia nigra, locus ceruleus, dorsal motor nucleus of the vagus, thoracic intermediolateral nucleus and nucleus basalis of Meynert, in addition to the typical pathology of PSP. Immunohistochemical studies demonstrated that PSP-tau pathology was localized in the central nervous system, but Lewy body-related α-synucleinopathy was extensive in the central and peripheral nervous systems. Although PSP and PD may represent independent processes, this case could provide insight into a common defect in either protein phosphorylation or the proteinase surveillance system that contributes to human aging.
authors.affiliation: Department of Neurology, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders.|Department of Neurology, Nagoya University Graduate School of Medicine.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Araki
authors.affiliation: Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sumikura
authors.affiliation: Department of Neurology, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders.
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsudaira
authors.affiliation: Department of Neurology, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders.
authors.forename: Akira
authors.initials: A
authors.lastname: Sugiura
authors.affiliation: Department of Neurology, Saitama International Medical Center, Saitama Medical College.
authors.forename: Masaki
authors.initials: M
authors.lastname: Takao
authors.affiliation: Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Murayama
authors.affiliation: Department of Neurology, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Obi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D006801:Humans; D010300:Parkinson Disease / Q000150:complications* / Q000473:pathology*; D013494:Supranuclear Palsy, Progressive / Q000150:complications* / Q000473:pathology*
keywords: Parkinson's disease; alpha-synuclein; overlap; progressive supranuclear palsy; tau