title: Photoacoustic imaging of salivary glands.
abstract: In this work, we utilized photoacoustic imaging (PAI) with co-registered ultrasound (US) to non-invasively assess salivary gland function in vivo. A significant increase in salivary gland oxygen saturation was observed on PAI within minutes after gustatory stimulation of healthy mice reflective of the hyperemic response associated with secretion of saliva. Good correlation was seen between PAI and Doppler sonography. Salivary adenoid cystic carcinomas showed higher oxygen saturation compared to surrounding salivary gland tissue. Our results demonstrate the potential clinical utility of PAI for visualization of salivary gland physiology and pathology.
authors.affiliation: Laboratory for Translational Imaging, Department of Molecular and Cellular Biophysics and Biochemistry, Roswell Park Cancer Institute, Buffalo, New York 14263, USA ; Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
authors.forename: Laurie J
authors.initials: LJ
authors.lastname: Rich
authors.affiliation: Laboratory for Translational Imaging, Department of Molecular and Cellular Biophysics and Biochemistry, Roswell Park Cancer Institute, Buffalo, New York 14263, USA ; Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA ; Department of Head and Neck Surgery, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
authors.forename: Mukund
authors.initials: M
authors.lastname: Seshadri
keywords: (170.3880) Medical and biological imaging; (170.4580) Optical diagnostics for medicine; (170.4940) Otolaryngology; (170.5120) Photoacoustic imaging; (170.7170) Ultrasound