title: Effects of 5-aminolevulinic acid on a murine model of diet-induced obesity.
abstract: The effects of 5-aminolevulinic acid (5-ALA) on obesity were investigated using a murine model (diet-induced obese mice). Diet-induced obese mice were divided into 4 groups: a control group (C group), which was fed a high-fat diet; a low-5-ALA dose (10 mg/kg/day) group (10A group); a moderate-5-ALA dose (30 mg/kg/day) group (30A group); and a high-5-ALA dose (100 mg/kg/day) group (100A group). 5-ALA was administered by mixing the high fat diet for 8 weeks. Body weight increases in the 30A and 100A groups were significantly smaller compared with those of the C group. Body fat measurements by X-ray computed tomography indicated that the 100A group showed a tendency toward low visceral fat quantities during the final week of the study. Visceral fat weights in the 30A and 100A groups were slightly low. The levels of serum alanine aminotransferase (ALT) and total cholesterol (TC) in the 10A group was slightly low, whereas the 30A and 100A groups showed significantly lower ALT and TC values. Liver lipid concentration showed a dose-dependent decrease with ALA. Thus, in this diet-induced obese murine model, administration of 5-ALA had a significantly beneficial impact on the visceral fat, serum ALT and TC, and liver lipid concentration.
authors.affiliation: Nutrition Research Department, Food Science Research Laboratories, Meiji Co., Ltd., 540 Naruda, Odawara, Kanagawa 250-0862, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Koganei
authors.affiliation: Nutrition Research Department, Food Science Research Laboratories, Meiji Co., Ltd., 540 Naruda, Odawara, Kanagawa 250-0862, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Saitou
authors.affiliation: SBI Pharma Co., Ltd., Izumi Garden Tower 20F, 1-6-1 Roppongi, Minato, Tokyo 106-6020, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tsuchiya
authors.affiliation: SBI Pharma Co., Ltd., Izumi Garden Tower 20F, 1-6-1 Roppongi, Minato, Tokyo 106-6020, Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Abe
authors.affiliation: SBI Pharma Co., Ltd., Izumi Garden Tower 20F, 1-6-1 Roppongi, Minato, Tokyo 106-6020, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Biomaterial in Tokyo Co., Ltd., 5-4-19-301B Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Horinouchi
authors.affiliation: Biomaterial in Tokyo Co., Ltd., 5-4-19-301B Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Izumi
authors.affiliation: Nutrition Research Department, Food Science Research Laboratories, Meiji Co., Ltd., 540 Naruda, Odawara, Kanagawa 250-0862, Japan.
authors.forename: Taketo
authors.initials: T
authors.lastname: Yamaji
authors.affiliation: Nutrition Research Department, Food Science Research Laboratories, Meiji Co., Ltd., 540 Naruda, Odawara, Kanagawa 250-0862, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takahashi
keywords: 5-aminolevulinic acid; diet-induced obese mouse model; high fat diet; lipid metabolism; visceral fat