title: Preparation of Self-Activated Fluorescence Mesoporous Silica Hollow Nanoellipsoids for Theranostics.
abstract: The newly developed multifunctional (self-activated fluorescent, mesoporous, and biocompatible) hollow mesoporous silica nanoellipsoids (f-hMS) are potentially useful as a delivery system of drugs for therapeutics and imaging purposes. For the synthesis of f-hMS, self-activated fluorescence hydroxyapatite (fHA) was used as a core template. A mesoporous silica shell was obtained by silica formation and subsequent removal of the fHA core, which resulted in a hollow-cored f-hMS. Although the silica shell provided a highly mesoporous structure, enabling an effective loading of drug molecules, the fluorescent property of fHA was also well-preserved in the f-hMS. Cytochrome c and doxorubicin, used as a model protein and anticancer drug, respectively, were shown to be effectively loaded onto f-hMS and were then released in a sustainable and controllable manner. The f-hMS was effectively taken up by the cells and exhibited fluorescent labeling while preserving excellent cell viability. Overall, the f-hMS nanoreservoir may be useful as a multifunctional carrier system for drug delivery and cell imaging.
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), ‡Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, and §Department of Biomaterials Science, School of Dentistry, Dankook University , Cheonan 330-714, South Korea.
authors.forename: Rajendra Kumar
authors.initials: RK
authors.lastname: Singh
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), ‡Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, and §Department of Biomaterials Science, School of Dentistry, Dankook University , Cheonan 330-714, South Korea.
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), ‡Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, and §Department of Biomaterials Science, School of Dentistry, Dankook University , Cheonan 330-714, South Korea.
authors.forename: Chinmaya
authors.initials: C
authors.lastname: Mahapatra
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), ‡Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, and §Department of Biomaterials Science, School of Dentistry, Dankook University , Cheonan 330-714, South Korea.
authors.forename: Kapil Dev
authors.initials: KD
authors.lastname: Patel
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), ‡Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, and §Department of Biomaterials Science, School of Dentistry, Dankook University , Cheonan 330-714, South Korea.
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Kim
mesh_terms: D005453:Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D000068936:Theranostic Nanomedicine
chemical_list: D012822:Silicon Dioxide