title: [Study on protective effect of Sijunzi decoction (red/white ginseng) on H2O2-induced H9c2 cardiomyocytes apoptosis].
abstract: In this study, efforts were made to screen out the drug concentration of Sijunzi decoction (red ginseng) for in vitro intervention of H9c2 cardiomyocytes, select high, medium and low groups for subsequent experiments, establish the H2O2-induced myocardial cell apoptosis to investigate the protective effect of Sijunzi decoction (white/red ginseng), provide reference ginseng ingredients in Sijunzi decoction used to treat ischemic heart disease and reflect its curative effect, and observe its impacts on SOD, MAD, LDH and other indexes to preliminarily define the action mechanism. According to the results, red ginseng in Sijunzi decoction showed a better protective effect on H2O2-induced myocardial cell injury than that of white ginseng. Both of them could enhance SOD activity and reduce MDA production and LDH release, so as to significantly reduce the amount of apoptotic myocardial cells and play protective role.
authors.forename: Na
authors.initials: N
authors.lastname: Sun
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Shan
authors.initials: S
authors.lastname: Xu
authors.forename: Peng-peng
authors.initials: PP
authors.lastname: Liu
authors.forename: Tian-zhu
authors.initials: TZ
authors.lastname: Jia
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D005894:Panax / Q000737:chemistry*; D020011:Protective Agents / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D006861:Hydrogen Peroxide