title: Advances in the clinical research of the minimally invasive treatment for the posterior edge of vertebral-body defects by spinal metastases.
abstract: Spinal metastasis is one of the commonly observed complications in the advanced stages of cancer patients, and is a serious threat to human life and health. Malignant tumor invasion usually leads to defects in the posterior margins of the vertebral body, which caused significant cancer pains to patients and increased the risk of surgery. Currently, minimally invasive treatments of vertebral defects caused by spinal metastases include percutaneous vertebroplasty (PVP) combined with radiofrequency ablation and PVP combined with125I seed implantation. These minimally invasive techniques have particular superiority to control pain in patients with spinal metastases, improve nerve function, reduce the incidence of fractures and surgical risk, and improve the quality of life. The present study reviewed the progress in clinical research on vertebral defects caused by spinal metastases, and the mechanisms and minimally invasive treatment.
authors.affiliation: Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650118, P.R. China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650118, P.R. China.
authors.forename: Zuozhang
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650118, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
authors.affiliation: Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650118, P.R. China.
authors.forename: Zongqin
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650118, P.R. China.
authors.forename: Mingyan
authors.initials: M
authors.lastname: Ren
authors.affiliation: Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650118, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Han
keywords: clinical research; minimally invasive treatment; posterior vertebral-body defects; spinal metastases