title: Relationship between serum adiponectin and osteoprotegerin levels and coronary heart disease severity.
abstract: This study aimed to explore serum adiponectin and osteoprotegerin levels in patients with coronary heart disease (CHD) and their correlation with inflammatory and ischemia factors. From September 2010 to Augest 2010, 347 CHD patients were enrolled for a retrospective analysis. Serum lipoprotein phospholipase A2 (Lp-PLA2), hypersensitive C-reactive protein (hs-CRP), ischemia modified albumin (IMA), and adiponectin and osteoprotegerin levels were detected and analyzed. Serum adiponectin levels (ng/mL, CV was 4.3% at 250 ng/mL) were found to be negatively correlated with Lp-PLA2 (r = -0.958, P = 0.014) and hs-CRP (r = -0.958, P = 0.015) and positively correlated with IMA (r = 0.962, P = 0.025). Serum osteoprotegerin levels were positively correlated with Lp-PLA2 (r = 0.933, P = 0.027) and hs-CRP (r = 0.932, P = 0.022) and negatively correlated with IMA (r = -0.924, P = 0.017). In addition, serum adiponectin levels negatively correlated with osteoprotegerin levels. In conclusion, serum adiponectin level was negatively correlated with CHD progression, whereas serum osteoprotegerin level was positively correlated with CHD progression. Combined detection of adiponectin and osteoprotegerin levels may be of potential value in the clinical determination of CHD severity.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Shandong Jining Medical College, Jining, Shandong, China HuilingZhang123@126.com.
authors.forename: H L
authors.initials: HL
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Affiliated Hospital of Shandong Jining Medical College, Jining, Shandong, China.
authors.forename: X
authors.initials: X
authors.lastname: Jin
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D001483:Base Sequence; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human