title: Ovarian infertility is associated with cardiovascular disease risk factors in later life: A Japanese cross-sectional study.
abstract: OBJECTIVE
  This study aimed to clarify the association between ovarian infertility and cardiovascular disease risk factors in later life in Japanese women.
  
  
  METHODS
  The Japan Nurses' Health Study (JNHS) is a cohort study of Japanese women's health. Data from the JNHS baseline survey (n = 49,927) between 2001 and 2007 were used in a cross-sectional, retrospective analysis. A total of 44,601 women were classified into three categories: ovarian infertility group (n=1167), other infertility group (n = 4619), and no infertility group (n = 38,815). Logistic regression analysis compared with the no infertility group was performed.
  
  
  METHODS
  Age-adjusted odds ratios (ORs) and multivariable-adjusted ORs for hypertension, hypercholesterolemia, and diabetes mellitus (DM).
  
  
  RESULTS
  The prevalence of obese women (BMI ≥ 25) who were < 45 years old in the ovarian infertility group was significantly higher compared with that in the other groups. Women in the ovarian infertility group were at risk for hypertension at ≥ 45 years old (age-adjusted OR: 1.65%, confidence interval [CI]: 1.23-2.21); for hypercholesterolemia at < 45 and ≥ 45 years old (age-adjusted OR: 1.42, 95% CI: 1.06-1.88 at < 45 years; age-adjusted OR: 1.39, 95% CI: 1.06-1.81 at ≥ 45 years); and for DM at < 45 years old (age-adjusted OR: 2.92, 95% CI: 1.57-5.46).
  
  
  CONCLUSIONS
  Japanese women with ovarian infertility (most women have polycystic ovary syndrome) are at high risk of hypertension from 45 years of age, hypercholesterolemia at all ages, and diabetes mellitus (DM) before 45 years old.
authors.affiliation: Department of Obstetrics and Gynecology, Niigata City General Hospital, Niigata 950-1197, Japan. Electronic address: takumi@hosp.niigata.niigata.jp.
authors.forename: Takumi
authors.initials: T
authors.lastname: Kurabayashi
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki, Aomori 036-8562, Japan. Electronic address: mizunuma@cc.hirosaki-u.ac.jp.
authors.forename: Hideki
authors.initials: H
authors.lastname: Mizunuma
authors.affiliation: Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, Japan. Electronic address: t.kubota.gyne@tmd.ac.jp.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kubota
authors.affiliation: Unit of Community Health Sciences, School of Health Sciences, Gunma University, Maebashi, Gunma 371-8511, Japan. Electronic address: khayashi@gunma-u.ac.jp.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology*; D006973:Hypertension / Q000453:epidemiology*; D007247:Infertility, Female / Q000453:epidemiology*; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Cardiovascular disease; Health study (JNHS); Japan nurses’; Ovarian infertility; Polycystic ovary syndrome; Women’s health