title: Systematically identify key genes in inflammatory and non-inflammatory breast cancer.
abstract: Although the gene expression in breast tumor stroma, playing a critical role in determining inflammatory breast cancer (IBC) phenotype, has been proved to be significantly different between IBC and non-inflammatory breast cancer (non-IBC), more effort needs to systematically investigate the gene expression profiles between tumor epithelium and stroma and to efficiently uncover the potential molecular networks and critical genes for IBC and non-IBC. Here, we comprehensively analyzed and compared the transcriptional profiles from IBC and non-IBC patients using hierarchical clustering, protein-protein interaction (PPI) network, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) database analyses, and identified PDGFRβ, SUMO1, COL1A1, FYN, CAV1, COL5A1 and MMP2 to be the key genes for breast cancer. Interestingly, PDGFRβ was found to be the hub gene in both IBC and non-IBC; SUMO1 and COL1A1 were respectively the key genes for IBC and non-IBC. These analysis results indicated that those key genes might play important role in IBC and non-IBC and provided some clues for future studies.
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Fan
authors.initials: F
authors.lastname: Chai
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Minghao
authors.initials: M
authors.lastname: Wang
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. Electronic address: jiangjunchq@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016000:Cluster Analysis; D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D030541:Databases, Genetic; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D063990:Gene Ontology; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D060066:Protein Interaction Maps; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000235:genetics*; D025842:SUMO-1 Protein / Q000235:genetics*
chemical_list: D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D025842:SUMO-1 Protein; C495501:SUMO1 protein, human; C000605860:PDGFRB protein, human; D020797:Receptor, Platelet-Derived Growth Factor beta
keywords: Inflammatory breast cancer; PDGFRβ, SUMO1 and COL1A1; Tumor microenvironment; non-inflammatory breast cancer