title: Selective V₂-Agonist of Vasopressin Desmopressin Stimulates Activity of Serum Hyaluronidase.
abstract: Effects of desmopressin (arginine vasopressin V2 receptor agonist) were studied for elucidation of the possible role of the kidneys in the regulation of blood hyaluronidase activity. Similar to vasopressin, intraperitoneal administration of desmopressin to Wistar rats increased blood hyaluronidase activity by 30%. Against the background of water load, nether desmopressin nor vasopressin increased blood hyaluronidase activity. The possibility of renal secretion of hyaluronidase into the blood as a mechanism of antidiuretic activity of vasopressin and its role in the regulation of water metabolism are discussed.
authors.affiliation: K. L. Khetagurov North Ossetian State University; Vladikavkaz Research Center of the Russian Academy of Sciences and the Government of the Republic of North Ossetia-Alania, Vladikavkaz, Russia. stanislavdzgoev@yandex.ru.
authors.forename: S G
authors.initials: SG
authors.lastname: Dzgoev
mesh_terms: D000818:Animals; D050034:Antidiuretic Agents / Q000494:pharmacology; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D005260:Female; D006821:Hyaluronoglucosaminidase / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008297:Male; D017208:Rats, Wistar; D017483:Receptors, Vasopressin / Q000819:agonists* / Q000378:metabolism
chemical_list: D050034:Antidiuretic Agents; D017483:Receptors, Vasopressin; D006821:Hyaluronoglucosaminidase; D003894:Deamino Arginine Vasopressin
keywords: blood plasma; desmopressin; hyaluronic acid; hyaluronidase; vasopressin