title: Intracerebroventricular injection of adiponectin regulates locomotor activity in rats.
abstract: Enhancing exercise motivation is the best way to prevent obesity and diabetes. In this study, we examined whether adiponectin affects locomotion activity in Wister and Spontaneously-Running Tokushima-Shikoku (SPORTS) rats using two types of behavioral assays: home cage and wheel running activity. SPORTS rats were established from an original line from Wister strain that had shown high level of wheel running activity in our laboratory. Injection of adiponectin into the lateral ventricle of Wister rats and SPORTS rats decreased home cage activity, but no change was observed in the food intake and oxygen consumption. This result indicates the possibility that adiponectin can reduce non-exercise activity thermogenesis (NEAT) and physical activity via the central nervous system. In contrast, injection of adiponectin did not change wheel running activity in SPORTS rats. We produced hypothalamus-destructed model rat using monosodium glutamate (MSG) to elucidate the regulation site of adiponectin. Injection of adiponectin into MSG-treated SPORTS rats did not change amount of home cage activity and food intake, suggesting that adiponectin action on home cage activity was in the hypothalamic area. These results suggest that adiponectin regulates locomotion activity through mediobasal hypothalamus.
authors.affiliation: Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Miyatake
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shiuchi
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Ueta
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Akari
authors.initials: A
authors.lastname: Futami
authors.forename: Fukiko
authors.initials: F
authors.lastname: Sato
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Kitamura
authors.forename: Rie
authors.initials: R
authors.lastname: Tsutsumi
authors.forename: Nagakatsu
authors.initials: N
authors.lastname: Harada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakaya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakaue
mesh_terms: D052242:Adiponectin / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D007031:Hypothalamus / Q000187:drug effects* / Q000502:physiology; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000494:pharmacology
chemical_list: D052242:Adiponectin; D012970:Sodium Glutamate