title: Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice.
abstract: Two tetrapeptides, HAEE and RADD, which are ionic-complementary to the primary zinc recognition site of amyloid-β (Aβ), have been reported to inhibit zinc-induced dimerization of the Aβ metal-binding domain and slow Aβ aggregation in vitro. In the present study, we investigate the impact of HAEE and RADD on the development of cerebral β-amyloidosis in a mouse model of Alzheimer's disease. We have found chronic intravenous administration of each peptide results in significant decrease of amyloid plaque burden in the treated mice.
authors.affiliation: Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Faculté de Pharmacie, Marseille, France.|The Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: Philipp O
authors.initials: PO
authors.lastname: Tsvetkov
authors.affiliation: Branch of Shemyakin and Ovchinnikov Institute of bioorganic chemistry of Russian academy of sciences, Pushchino, Russia.
authors.forename: Ivan B
authors.initials: IB
authors.lastname: Cheglakov
authors.affiliation: Branch of Shemyakin and Ovchinnikov Institute of bioorganic chemistry of Russian academy of sciences, Pushchino, Russia.
authors.forename: Armen A
authors.initials: AA
authors.lastname: Ovsepyan
authors.affiliation: Kimonella Ventures Ltd., Limassol, Cyprus.
authors.forename: Oleg Y
authors.initials: OY
authors.lastname: Mediannikov
authors.affiliation: Kimonella Ventures Ltd., Limassol, Cyprus.
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Morozov
authors.affiliation: Branch of Shemyakin and Ovchinnikov Institute of bioorganic chemistry of Russian academy of sciences, Pushchino, Russia.
authors.forename: Georgy B
authors.initials: GB
authors.lastname: Telegin
authors.affiliation: Kimonella Ventures Ltd., Limassol, Cyprus.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Kozin
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D007275:Injections, Intravenous; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D009842:Oligopeptides / Q000627:therapeutic use*; D058225:Plaque, Amyloid / Q000188:drug therapy / Q000235:genetics; D053764:Presenilin-1 / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D014150:Antipsychotic Agents; D009842:Oligopeptides; D053764:Presenilin-1
keywords: Alzheimer’s disease; amyloid-β; mouse models; protein aggregation in vivo