title: Effect of Chronic Psychological Stress on Liver Metastasis of Colon Cancer in Mice.
abstract: Metastasis to the liver is a main factor in colorectal cancer mortality. Previous studies suggest that chronic psychological stress is important in cancer progression, but its effect on liver metastasis has not been investigated. To address this, we established a liver metastasis model in BALB/c nude mice to investigate the role of chronic stress in liver metastasis. Our data suggest that chronic stress elevates catecholamine levels and promotes liver metastasis. Chronic stress was also associated with increased tumor associated macrophages infiltration into the primary tumor and increased the expression of metastatic genes. Interestingly, β-blocker treatment reversed the effects of chronic stress on liver metastasis. Our results suggest the β-adrenergic signaling pathway is involved in regulating colorectal cancer progression and liver metastasis. Additionally, we submit that adjunctive therapy with a β-blocker may complement existing colorectal cancer therapies.
authors.affiliation: Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liang
authors.affiliation: Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Ao
authors.initials: A
authors.lastname: Li
authors.affiliation: Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Sun
mesh_terms: D000818:Animals; D015153:Blotting, Western; D003110:Colonic Neoplasms / Q000473:pathology* / Q000523:psychology; D004195:Disease Models, Animal; D005434:Flow Cytometry; D019073:HT29 Cells / Q000637:transplantation; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000523:psychology / Q000556:secondary*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D060888:Real-Time Polymerase Chain Reaction; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications*
chemical_list: D011943:Receptors, Adrenergic, beta