title: Senescence as a general cellular response to stress: A mini-review.
abstract: Cellular senescence was initially described as the phenomenon of limited cell divisions that normal cells in culture can undergo during long-term-cultivation. Later it was found that senescence may be induced by various stress factors. The intriguing resemblance between stress-induced and replicative senescence makes questionable the distinction between both types and suggests that the cellular senescence is a common outcome of stress response. Growing evidences support the idea that stress-induced senescence is the cell-type specific.
authors.affiliation: Department of Cell Signalization and Transport, Institute of Cytology RAS, St. Petersburg, Russia.
authors.forename: Irina
authors.initials: I
authors.lastname: Fridlyanskaya
authors.affiliation: Department of Cell Signalization and Transport, Institute of Cytology RAS, St. Petersburg, Russia. Electronic address: al.l.l@mail.ru.
authors.forename: Larisa
authors.initials: L
authors.lastname: Alekseenko
authors.affiliation: Department of Cell Signalization and Transport, Institute of Cytology RAS, St. Petersburg, Russia.
authors.forename: Nikolay
authors.initials: N
authors.lastname: Nikolsky
mesh_terms: D017209:Apoptosis; D002455:Cell Division; D016922:Cellular Senescence; D006801:Humans; D013234:Stem Cells / Q000166:cytology*; D013312:Stress, Physiological
keywords: Apoptosis; Senescence; Stem cells; Stress response