title: Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases.
abstract: Astroglia are a major cellular constituent of the central nervous system (CNS) and play crucial roles in brain development, function, and integrity. Increasing evidence demonstrates that astroglia dysfunction occurs in a variety of neurological disorders ranging from CNS injuries to genetic diseases and chronic degenerative conditions. These new insights herald the concept that transplantation of astroglia could be of therapeutic value in treating the injured or diseased CNS. Recent technological advances in the generation of human astroglia from stem and progenitor cells have been prominent. We propose that a better understanding of the suitability of astroglial cells in transplantation as well as of their therapeutic effects in animal models may lead to the establishment of astroglia-based therapies to treat neurological diseases.
authors.affiliation: Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, USA; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Sacramento, CA, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, University of California, Davis, CA, USA.
authors.forename: Albert
authors.initials: A
authors.lastname: Chan
authors.affiliation: Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, USA; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Sacramento, CA, USA.
authors.forename: Han
authors.initials: H
authors.lastname: Wen
authors.affiliation: College of Dentistry, University of Illinois, Chicago, IL, USA.
authors.forename: Seung-Hyuk
authors.initials: SH
authors.lastname: Chung
authors.affiliation: Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, USA; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Sacramento, CA, USA. Electronic address: wbdeng@ucdavis.edu.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Deng
authors.affiliation: Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, USA; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Sacramento, CA, USA; Department of Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, NE, USA. Electronic address: peng.jiang@unmc.edu.
authors.forename: Peng
authors.initials: P
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000637:transplantation*; D018929:Cell Culture Techniques / Q000379:methods; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006801:Humans; D009422:Nervous System Diseases / Q000628:therapy*; D013234:Stem Cells / Q000166:cytology*