title: A case of metastatic adenocarcinoma on a background of penoscrotal extramammary Paget's disease.
abstract: A 77-year-old man presented with a chronic lesion located in the left penoscrotal area. Apart from pruritus, bleeding and an occasional discharge from this area, he also reported reduced appetite and weight loss. Examination revealed an ulcerated skin lesion attached to a firm subcutaneous mass. Wide local excision of the lesion revealed invasive adenocarcinoma on a background of extramammary Paget's disease. Staging studies showed disseminated metastatic disease within the lymph nodes, and liver and bone metastases. He was treated with carboplatin and paclitaxel chemotherapy initially, but then continued only on Carboplatin chemotherapy due to side effects from Paclitaxel. Eleven weeks after the start of his chemotherapy, his restaging imaging showed reduced lymphadenopathy, unchanged liver metastasis and sclerosis of bone metastasis. With completion of chemotherapy, repeat imaging showed stable disease. The patient is currently on follow-up.
authors.affiliation: Department of Urology, University College London Hospital, London, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Christodoulidou
authors.affiliation: Department of Histopathology, University College London Hospital, London, UK.
authors.forename: Pramit
authors.initials: P
authors.lastname: Khetrapal
authors.affiliation: Department of Oncology, University College London Hospital, London, UK.
authors.forename: Anita
authors.initials: A
authors.lastname: Mitra
authors.affiliation: Department of Urology, University College London Hospital, London, UK.
authors.forename: Asif
authors.initials: A
authors.lastname: Muneer
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary; D000368:Aged; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D005834:Genital Neoplasms, Male / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010145:Paget Disease, Extramammary / Q000188:drug therapy / Q000473:pathology*; D035583:Rare Diseases