title: Obstructive sleep apnea in Prader-Willi syndrome: risks and advantages of adenotonsillectomy.
abstract: Obstructive sleep apnea is a well-known clinical manifestation of Prader-Willi syndrome. The aim of our study is to evaluate the efficacy of adenotonsillectomy for the treatment of the disorder as well as the improvement of their post-operative quality of life. Five patients with moderate to severe obstructive sleep apneas and adenotonsillar hypertrophy of grade III-IV underwent adenotonsillectomy. Pre- and postoperative apneas and Quality of Life were assessed respectively with a polysomnography with multi-sleep latency test and with the pediatric Quality of Life questionnaire, performed before and 6 months after surgery. A decrease of apnea/hypopnea index values has been detected between pre- and post-surgery (t=2.64, P=0.005), as well as oxygen desaturation index values (t=5.51, P=0.005), multi-sleep latency test (t=4.54, P=0.01), and of the values of pediatric Quality of Life questionnaire. No correlation has been detected between body mass index and apnea/hypopnea index, oxygen desaturation index and multi-sleep latency test values pre- and post-adenotonsillectomy. A correlation has been found between multi-sleep latency test and oxygen desaturation index values post-surgery (P=0.04). No post-operative complications were observed. Our data underline the efficacy of surgery in Prader-Willi patients with adenotonsillar hypertrophy in order to improve their quality of life.
authors.affiliation: Otorhinolaryngology Unit, San Raffaele Hospital and Vita-Salute University, Milan. giordano.leone@hsr.it.
authors.forename: Leone
authors.initials: L
authors.lastname: Giordano
authors.forename: Salvatore
authors.initials: S
authors.lastname: Toma
authors.forename: Francesca
authors.initials: F
authors.lastname: Palonta
authors.forename: Roberto
authors.initials: R
authors.lastname: Teggi
authors.forename: Marco
authors.initials: M
authors.lastname: Zucconi
authors.forename: Stefania
authors.initials: S
authors.lastname: Di Candia
authors.forename: Mario
authors.initials: M
authors.lastname: Bussi
mesh_terms: D000233:Adenoidectomy / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D011218:Prader-Willi Syndrome / Q000150:complications* / Q000601:surgery; D011788:Quality of Life; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000209:etiology* / Q000601:surgery; D011795:Surveys and Questionnaires; D014068:Tonsillectomy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D010100:Oxygen