title: Factors Influencing Hematopoietic Stem Cell Donation Intention in Hong Kong: A Web-Based Survey.
abstract: BACKGROUND
  Hematopoietic stem cell transplantation (HSCT) has become increasingly common for treatment of severe hematological disorders. However, the number of compatible hematopoietic stem cell (HSC) donors is usually limited. Expanding donor pool size would enhance matching success by increasing donor frequency and introducing allelic diversity within the registry. Identifying factors that affect public willingness towards HSC donation allows better strategic recruitment planning to facilitate donor pool expansion. Previous studies in white populations showed knowledge, family attitude, trust towards the healthcare system, fear, self-identity, and social identity are important factors related to HSC donation intention. However, given the differences in cultural and society values that exist across different regions, in particular between the East and West, whether these factors influence HSC donation willingness in Hong Kong remained to be determined. The objective of this study was to identify factors associated with HSC donation motivation in Hong Kong.
  
  
  METHODS
  A large-scale, cross-sectional, observational study involving 3479 local participants.
  
  
  RESULTS
  There is a positive correlation of HSC donation intention with younger age (18-32, OR: 1.80, p≤0·001) and higher education (OR: 1·47, p≤0.001). Better HSCT knowledge is also related to greater HSC donation intention (OR: 2.55, p£0.001).
  
  
  CONCLUSIONS
  Our data suggests HSCT education could help to improve donor recruitment and that more resources should be allocated for public education.
authors.affiliation: Division of Transplantation and Immunogenetics, Department of Pathology and Clinical Biochemistry, Queen Mary Hospital, Hong Kong, Hong Kong.
authors.forename: Janette
authors.initials: J
authors.lastname: Kwok
authors.affiliation: Division of Transplantation and Immunogenetics, Department of Pathology and Clinical Biochemistry, Queen Mary Hospital, Hong Kong, Hong Kong.
authors.forename: Eva
authors.initials: E
authors.lastname: Leung
authors.affiliation: Division of Transplantation and Immunogenetics, Department of Pathology and Clinical Biochemistry, Queen Mary Hospital, Hong Kong, Hong Kong.
authors.forename: William
authors.initials: W
authors.lastname: Wong
authors.affiliation: Departmental of Pathology, North District Hospital, Hong Kong, Hong Kong.
authors.forename: Kate
authors.initials: K
authors.lastname: Leung
authors.affiliation: Department of Blood Collection and Donor Recruitment, Hong Kong Red Cross Blood Transfusion Service, Hong Kong, Hong Kong.
authors.forename: Cheuk Kwong
authors.initials: CK
authors.lastname: Lee
authors.affiliation: Division of Behavioural Sciences, School of Public Health, Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
authors.forename: Wendy
authors.initials: W
authors.lastname: Lam
authors.affiliation: Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, Hong Kong.
authors.forename: Patrick
authors.initials: P
authors.lastname: Ip
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D003466:Cultural Characteristics; D005260:Female; D006293:Health Promotion / Q000458:organization & administration*; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data* / Q000639:trends; D006723:Hong Kong; D006801:Humans; D015994:Incidence; D020407:Internet; D019520:Living Donors / Q000193:education* / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020380:Needs Assessment; D012307:Risk Factors; D012737:Sex Factors; D014019:Tissue Donors / Q000193:education / Q000706:statistics & numerical data; D009927:Tissue and Organ Procurement / Q000458:organization & administration*; D055815:Young Adult