title: Quantification of 4'-geranyloxyferulic acid (GOFA) in honey samples of different origin by validated RP-HPLC-UV method.
abstract: Natural honey has been employed as a nutraceutical agent with benefits and therapeutic promises for humans for many centuries. It has been largely used as food and medicine by all generations, traditions, and civilizations, both ancient and modern. Several chemicals having beneficial effects for human health have been reported as components of natural honey and these include sugars, organic acids, aminoacids, minerals, and vitamins. Also some important phytochemicals have been described and these comprise tannins, flavonoids, terpenes, saponins, and alkaloids. In this note it is described the successful application of a RP HPLC-UV-vis method for the separation and quantification of 4'-geranyloxyferulic acid (GOFA) in four honey samples of different origin. Concentration values showed a great variation between the four samples tested, being chestnut honey the one richest in GOFA (7.87 mg/g). The findings described herein represent the first example reported in the literature of the characterization of an oxyprenylated phenylpropanoid in honey.
authors.affiliation: Dipartimento di Farmacia, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, CH, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.affiliation: Dipartimento di Farmacia, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, CH, Italy.
authors.forename: Vito Alessandro
authors.initials: VA
authors.lastname: Taddeo
authors.affiliation: Dipartimento di Farmacia, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, CH, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Fiorito
authors.affiliation: Dipartimento di Farmacia, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, CH, Italy. Electronic address: francesco.epifano@unich.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000592:standards; D003373:Coumaric Acids / Q000032:analysis*; D006722:Honey / Q000032:analysis*; D006801:Humans; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet / Q000379:methods / Q000592:standards
chemical_list: C552732:4'-geranyloxyferulic acid; D003373:Coumaric Acids
keywords: Cancer chemoprevention; Diet; Geranyloxyferulic acid; Honey; Oxyprenylated secondary metabolites; Prenyloxyphenylpropanoids