title: Competition and collaboration between different actin assembly pathways allows for homeostatic control of the actin cytoskeleton.
abstract: Tremendous insight into actin-associated proteins has come from careful biochemical and cell biological characterization of their activities and regulation. However, many studies of their cellular behavior have only considered each in isolation. Recent efforts reveal that assembly factors compete for polymerization-competent actin monomers, suggesting that actin is homeostatically regulated. It seems that a major regulatory component is competition between Arp2/3-activating nucleation promoting factors and profilin for actin monomers. The result is differential delivery of actin to different pathways, allowing for simultaneous assembly of competing F-actin structures and collaborative building of higher order cellular structures. Although there are likely to be additional factors that regulate actin homeostasis, especially in a cell type-dependent fashion, we advance the notion that competition between actin assembly factors results in a tunable system that can be adjusted according to extracellular and intracellular cues.
authors.affiliation: a UNC Lineberger Comprehensive Cancer Center; University of North Carolina at Chapel Hill ; Chapel Hill , NC USA.|b Department of Cell Biology and Physiology; University of North Carolina at Chapel Hill ; Chapel Hill , NC USA.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Rotty
authors.affiliation: a UNC Lineberger Comprehensive Cancer Center; University of North Carolina at Chapel Hill ; Chapel Hill , NC USA.|b Department of Cell Biology and Physiology; University of North Carolina at Chapel Hill ; Chapel Hill , NC USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Bear
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D051304:Profilins / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D051304:Profilins; D029702:Schizosaccharomyces pombe Proteins
keywords: Arp2/3 complex; Ena/VASP; actin; formin; motility; profilin