title: Impaired target detection in schizophrenia and the ventral attentional network: Findings from a joint event-related potential-functional MRI analysis.
abstract: Schizophrenia patients have abnormal neural responses to salient, infrequent events. We integrated event-related potentials (ERP) and fMRI to examine the contributions of the ventral (salience) and dorsal (sustained) attention networks to this dysfunctional neural activation. Twenty-one schizophrenia patients and 22 healthy controls were assessed in separate sessions with ERP and fMRI during a visual oddball task. Visual P100, N100, and P300 ERP waveforms and fMRI activation were assessed. A joint independent components analysis (jICA) on the ERP and fMRI data were conducted. Patients exhibited reduced P300, but not P100 or N100, amplitudes to targets and reduced fMRI neural activation in both dorsal and ventral attentional networks compared with controls. However, the jICA revealed that the P300 was linked specifically to activation in the ventral (salience) network, including anterior cingulate, anterior insula, and temporal parietal junction, with patients exhibiting significantly lower activation. The P100 and N100 were linked to activation in the dorsal (sustained) network, with no group differences in level of activation. This joint analysis approach revealed the nature of target detection deficits that were not discernable by either imaging methodology alone, highlighting the utility of a multimodal fMRI and ERP approach to understand attentional network deficits in schizophrenia.
authors.affiliation: Veterans Affairs Greater Los Angeles Healthcare System, MIRECC, Bldg. 210, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA ; Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Wynn
authors.affiliation: Veterans Affairs Greater Los Angeles Healthcare System, MIRECC, Bldg. 210, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Jimenez
authors.affiliation: San Francisco Veterans Affairs Medical Center, Northern California Institute for Research and Education, 4150 Clement Street, 151NC, San Francisco, CA 94121-1545, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Roach
authors.affiliation: Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Korb
authors.affiliation: Veterans Affairs Greater Los Angeles Healthcare System, MIRECC, Bldg. 210, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA ; Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Junghee
authors.initials: J
authors.lastname: Lee
authors.affiliation: Veterans Affairs Greater Los Angeles Healthcare System, MIRECC, Bldg. 210, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA ; Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: William P
authors.initials: WP
authors.lastname: Horan
authors.affiliation: San Francisco Veterans Affairs Medical Center, Northern California Institute for Research and Education, 4150 Clement Street, 151NC, San Francisco, CA 94121-1545, USA ; University of California, San Francisco, School of Medicine, 4150 Clement Street, San Francisco, CA 94143, USA.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Ford
authors.affiliation: Veterans Affairs Greater Los Angeles Healthcare System, MIRECC, Bldg. 210, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA ; Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Green
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300; D005071:Evoked Potentials; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D012559:Schizophrenia / Q000503:physiopathology*; D014796:Visual Perception / Q000502:physiology*
keywords: ERP; Joint ICA; Oddball; Salience network; fMRI