title: Primary Intraosseous Squamous Cell Carcinoma of the Jaws: 6 New Cases, Experience, and Literature Comparison.
abstract: OBJECTIVE
  To analyze the clinical, histologic, radiologic, therapeutic, and prognostic aspects of 6 cases of an uncommon head and neck malignancy and compare these results with data in the literature.
  
  
  METHODS
  The medical histories of all patients treated in the Maxillofacial Surgery Unit in San Gerardo Hospital (Monza, Italy) for primitive intraosseous squamous cell carcinoma (PIOSCC) of the jaw were reviewed. All patients were considered suitable for inclusion in the study, specifically those whose oral mucosa had not been compromised and who did not have distant metastases.
  
  
  RESULTS
  Six patients were included (4 male, 2 female). The odontogenic origin was histologically shown in only 2 patients. The male-to-female ratio was 2:1, and the malignancy occurred in the posterior mandible in 50% of cases. The most common symptoms were swelling and pain, but no sensory disturbances were observed. Radiologic findings indicated considerable variation in presentation, including small cystic lesions, which might complicate a pathologic diagnosis. All patients in the study were treated with surgery, and 2 patients received adjuvant radiotherapy. Cervical node metastases were present in 33% of patients. All patients are currently alive and free of disease.
  
  
  CONCLUSIONS
  PIOSCC is a rare malignancy of the head and neck. Diagnosis can be difficult during the early stages of disease owing to a lack of clinical symptoms or radiologic presentation. Treatment is surgical and, like every other cancer, must be adequate to cure the cancer.
authors.affiliation: Chief Assistant, Department of Oral and Maxillofacial Surgery, University of Milan Bicocca and Hospital San Gerardo, Monza, Italy. Electronic address: pietro.boni81@gmail.com.
authors.forename: Pietro
authors.initials: P
authors.lastname: Boni
authors.affiliation: Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Milan Bicocca and Hospital San Gerardo, Monza, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Sozzi
authors.affiliation: Chief Assistant, Department of Oral and Maxillofacial Surgery, University of Milan Bicocca and Hospital San Gerardo, Monza, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Novelli
authors.affiliation: Assistant Professor, Department of Pathology, University of Milan Bicocca and Hospital San Gerardo, Monza, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Pagni
authors.affiliation: Chief Assistant, Department of Pathology, University of Milan Bicocca and Hospital San Gerardo, Monza, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Valente
authors.affiliation: Professor and Chief, Department of Oral and Maxillofacial Surgery, University of Milan Bicocca and Hospital San Gerardo, Monza, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Bozzetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008441:Maxillary Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D037981:Neck Dissection / Q000379:methods; D018714:Radiotherapy, Adjuvant; D019651:Plastic Surgery Procedures / Q000379:methods