title: The value of a rapid contrast-enhanced angio-MRI protocol in the detection of head and neck paragangliomas in SDHx mutations carriers: a retrospective study on behalf of the PGL.EVA investigators.
abstract: OBJECTIVE
  To assess the performance of a simplified MRI protocol consisting of a contrast-enhanced three-dimensional MR angiography (CE-MRA) in association with a post-contrast T1-weighted sequence (T1WIV) for the detection of HNPGLs in SDHx mutation carriers.
  
  
  METHODS
  This retrospective sub-study is based on the multicenter PGL.EVA cohort, which prospectively enrolled SDHx mutation carriers from 2005 to 2009; 157 index cases or relatives were included. CE-MRA and the T1WIV images were read solely with knowledge of the clinical data but blind to the diagnosis. Sensitivity, specificity and likelihood ratios for the simplified MRI protocol were compared to the full MRI protocol reading results and to the gold standard status obtained through the consensus of an expert committee.
  
  
  RESULTS
  The sensitivity and specificity of the readings of the simplified MRI protocol were, respectively, 88.7 % (95 % CI = 78.1-95.3) and 93.7 % (95 % CI = 86.8-97.7) versus 80.7 % (95 % CI = 68.6-89.6) and 94.7 % (95 % CI = 88.1-98.3) for the readings of the full MRI protocol.
  
  
  CONCLUSIONS
  The simplified post-contrast MRI with shorter duration (5 to 10 minutes) showed no performance difference compared to the lengthy standard full MRI and can be proposed for the detection of head and neck paragangliomas (HNPGLs) in SDHx mutation carriers.
  
  
  CONCLUSIONS
  • Rapid angio-MRI protocol and the usual lengthy protocol show equal diagnostic performance. • The CE-MRA is the key sequence for the detection of HNPGLs. • The T1WIV sequence assists in localizing HNPGLs.
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service de Radiologie, Hôpital Européen Georges Pompidou, F-75015, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Gravel
authors.affiliation: Assistance Publique-Hôpitaux de Marseille, Service d'Endocrinologie, Diabète et Maladies Métaboliques, Centre Hospitalier Universitaire la Timone, F-13000, Marseille, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Niccoli
authors.affiliation: Service d'Endocrinologie, Diabétologie, Nutrition, Centre Hospitalier Universitaire d'Angers, F-49933, Angers, France.|LUNAM Université, INSERM, U1063, F-49933, Angers, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Rohmer
authors.affiliation: Assistance Publique-Hôpitaux de Marseille, Service de Radiologie, Centre Hospitalier Universitaire la Timone, F-13000, Marseille, France.
authors.forename: Guy
authors.initials: G
authors.lastname: Moulin
authors.affiliation: Hospices civils de Lyon, Groupement Hospitalier Est, Fédération d'Endocrinologie, F-69003, Lyon, France.|Faculté de Médecine Lyon-Est, Université de Lyon, F-69372, Lyon, France.|INSERM UMR1052, UMR CNRS 5286, Cancer Research Center of Lyon, F-69008, Lyon, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Borson-Chazot
authors.affiliation: Groupement Hospitalier Est, Service de Radiologie, Hospices civils de Lyon, F-69003, Lyon, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Rousset
authors.affiliation: Service de Radiologie, Centre Hospitalier Universitaire d'Angers, F-49933, Angers, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Pasco-Papon
authors.affiliation: Service de Radiologie, Centre Hospitalo-Universitaire de Reims, F-51000, Reims, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Marcus
authors.affiliation: Service de Radiologie, Centre Hospitalo-Universitaire de Lille, F-59000, Lille, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Dubrulle
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service de Radiologie, Hôpital Cochin, F-75006, Paris, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Gouya
authors.affiliation: Service de Radiologie, Institut Gustave Roussy, F-94800, Villejuif, France.
authors.forename: François
authors.initials: F
authors.lastname: Bidault
authors.affiliation: Service de Radiologie, Centre Hospitalo-Universitaire de Nantes, F-44000, Nantes, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Dupas
authors.affiliation: Service de Neuroradiologie, Centre Hospitalo-Universitaire de Clermont-Ferrand, F-63000, Clermont Ferrand, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Gabrillargues
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité d'Épidémiologie et de Recherche Clinique, F-75015, Paris, France.|INSERM, Centre d'investigation Épidémiologique 4, F-75015, Paris, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Caumont-Prim
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service de Radiologie, Hôpital Européen Georges Pompidou, F-75015, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Hernigou
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service de Génétique, Hôpital Européen Georges Pompidou, 20-40, rue Leblanc, 75015, Paris, France. anne-paule.gimenez-roqueplo@egp.aphp.fr.|INSERM, UMR970, Paris Cardiovascular Research Center, F-75015, Paris, France. anne-paule.gimenez-roqueplo@egp.aphp.fr.|Sorbonne Paris Cité, Faculté de Médecine, Université Paris Descartes, F-75006, Paris, France. anne-paule.gimenez-roqueplo@egp.aphp.fr.
authors.forename: Anne-Paule
authors.initials: AP
authors.lastname: Gimenez-Roqueplo
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service de Radiologie, Hôpital Européen Georges Pompidou, F-75015, Paris, France.|Sorbonne Paris Cité, Faculté de Médecine, Université Paris Descartes, F-75006, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Halimi
mesh_terms: D000328:Adult; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010235:Paraganglioma / Q000175:diagnosis* / Q000235:genetics; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
keywords: Head and neck; Magnetic resonance angiography; Paraganglioma; SDH; Screening