title: Developmental expression of estrogen receptor beta in the brain of prairie voles (Microtus ochrogaster).
abstract: Here, for the first time, the expression of estrogen receptor beta (ERβ) is characterized in the brains of the highly prosocial prairie vole (Microtus ochrogaster). ERβ immunoreactivity was compared in weanlings (postnatal Day 21) and adult males and females. The results indicate several major findings. First, unlike ERα, ERβ expression is not sexually dimorphic. Second, the adult pattern of ERβ-IR is established at the time of weaning, as there were no age-dependent effects on distribution. Finally, ERβ does not appear to be as widely distributed in voles compared with rats and mice. High levels of ERβ-IR were observed in several regions/nuclei within the medial pre-optic area, ventrolateral pre-optic nuclei, and in the hypothalamus, especially in the paraventricular and supraoptic nuclei. The visualization of ERβ in prairie voles is important as the socially monogamous prairie vole functions as a human relevant model system for studying the expression of social behavior and social deficit disorders. Future studies will now be able to determine the effect of treatments on the expression and/or development of ERβ in this highly social species.
authors.affiliation: Department of Biology and Integrated Bioscience Program, The University of Akron, Akron, OH, 44325.
authors.forename: Stephanie D
authors.initials: SD
authors.lastname: Ploskonka
authors.affiliation: Department of Biology and Integrated Bioscience Program, The University of Akron, Akron, OH, 44325.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Eaton
authors.affiliation: Department of Biological Sciences, University of Illinois Chicago, Chicago, IL, 60607.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Carr
authors.affiliation: Department of Biological Sciences, University of Illinois Chicago, Chicago, IL, 60607.
authors.forename: Jennifer V
authors.initials: JV
authors.lastname: Schmidt
authors.affiliation: Department of Biology and Integrated Bioscience Program, The University of Akron, Akron, OH, 44325. bcushing@utep.edu.|Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX, 79968. bcushing@utep.edu.
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Cushing
mesh_terms: D000367:Age Factors; D000818:Animals; D003411:Arvicolinae; D001522:Behavior, Animal; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D012737:Sex Factors; D012919:Social Behavior
chemical_list: D047629:Estrogen Receptor beta
keywords: hypothalamus; medial pre-optic area; pre-optic area; social monogamy