title: PIMASERTIB AND SEROUS RETINAL DETACHMENTS.
abstract: OBJECTIVE
  To report a case of multifocal serous retinal detachments associated with pimasertib.
  
  
  METHODS
  The authors report a 26-year-old patient who developed bilateral multifocal serous retinal detachments appearing 2 days after starting pimasertib (as part of a clinical trial investigating its use in low-grade metastatic ovarian cancer) and rapidly resolving 3 days after stopping it.
  
  
  CONCLUSIONS
  The mechanism of MEK inhibitor induced visual toxicity remains unclear. The pathophysiology of multifocal serous retinal detachments as a complication of pimasertib is still poorly understood.
authors.affiliation: Departments of *Ophthalmology and Vision Sciences, and †Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Alaa
authors.initials: A
authors.lastname: AlAli
authors.forename: Ahmad
authors.initials: A
authors.lastname: Bushehri
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Park
authors.forename: Hatem
authors.initials: H
authors.lastname: Krema
authors.forename: Wai-Ching
authors.initials: WC
authors.lastname: Lam
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D009536:Niacinamide / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000556:secondary; D047428:Protein Kinase Inhibitors; D012160:Retina / Q000187:drug effects / Q000473:pathology*; D012163:Retinal Detachment / Q000139:chemically induced* / Q000175:diagnosis; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
chemical_list: C550600:N-(2,3-dihydroxypropyl)-1-((2-fluoro-4-iodophenyl)amino)isonicotinamide; D047428:Protein Kinase Inhibitors; D009536:Niacinamide