title: An interesting case of an antihypertensive causing post-prostatectomy incontinence.
abstract: A 70-year-old man underwent a laparoscopic radical prostatectomy with preservation of bladder neck for T3aN0R0 prostate cancer in December 2009, (Gleason 4+3, negative surgical margin). His postoperative prostate-specific antigen rose from 0.01 to 0.05 ng/mL over 19 months. He had salvage radiotherapy in May 2012. Following radiotherapy, his urinary control worsened and he needed to wear up to four pads per day. He was being considered for an artificial urinary sphincter placement. He was also taking doxazosin for hypertension, which was discontinued. After stopping the doxazosin, his urinary control improved and he did not require any further intervention. Doctors should be aware of the effect of α-blockers on the internal sphincter and the risk of incontinence in patients post-prostate cancer treatment.
authors.affiliation: Department of MSc Advanced Surgical Practice, Cardiff University, Cardiff, UK Department of Urology, Wirral University Hospital, Wirral, UK.
authors.forename: Debashis
authors.initials: D
authors.lastname: Sarkar
authors.affiliation: Department of Urology, Wirral University Hospital, Wirral, UK.
authors.forename: Manal
authors.initials: M
authors.lastname: Kumar
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects*; D017292:Doxazosin / Q000009:adverse effects*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000097:blood / Q000601:surgery*; D016879:Salvage Therapy; D001743:Urinary Bladder / Q000601:surgery*; D014549:Urinary Incontinence / Q000209:etiology* / Q000628:therapy; D016741:Urinary Sphincter, Artificial
chemical_list: D000959:Antihypertensive Agents; D017430:Prostate-Specific Antigen; D017292:Doxazosin