title: [A CASE OF UROTHELIAL CARCINOMA OF THE URINARY BLADDER WITH SQUAMOUS DIFFERENTIATION RESPONDING TO PACLITAXEL AND CARBOPLATIN NEOADJUVANT CHEMOTHERAPY].
abstract: A 42-year-old man was referred to our hospital for macrohematuria. Computer tomography and magnetic resonance imaging revealed right hydronephrosis and a retroperitoneal mass, located next to right side of the bladder. Cystoscopy showed a protruded lesion covered with normal mucosa at the right lateral wall. The patient underwent transurethral resection of the bladder tumor and biopsies of the bladder wall. Histological examination showed squamous cell carcinoma. Neoadjuvant chemotherapy using paclitaxel and carboplatin (TC) was performed. A total cystectomy, right nephroureterectomy and construction of the ileal conduit were performed after one course of systemic chemotherapy. Histological examination showed urothelial carcinoma with squamous cell differentiation. Unexpectedly, a small amount of CIS was detected only in the vicinity of the TUR scar. The patient received 2 cycles of TC chemotherapy as adjuvant chemotherapy. Unfortunately, 11 months later, local recurrence and liver metastasis were detected. He died 17 months after the surgery.
authors.forename: Eri
authors.initials: E
authors.lastname: Banno
authors.forename: Aki
authors.initials: A
authors.lastname: Nishino
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nagai
authors.forename: Muneo
authors.initials: M
authors.lastname: Yasuda
authors.forename: Hideo
authors.initials: H
authors.lastname: Tahara
authors.forename: Shigeo
authors.initials: S
authors.lastname: Kino
authors.forename: Norihumi
authors.initials: N
authors.lastname: Kanno
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D017239:Paclitaxel / Q000008:administration & dosage; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D014523:Urethral Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013520:Urologic Surgical Procedures
chemical_list: D016190:Carboplatin; D017239:Paclitaxel