title: Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa.
abstract: Twelve new inositol derivatives, classified into myoinositol (1-6) and l-inositol (10-15) types, along with five known analogues were isolated from the whole plant of Inula cappa. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the tested compounds showed anti-inflammatory activities against the production of NO in RAW264.7 macrophages stimulated by lipopolysaccharide, with IC50 values ranging from 7 to 23 μM.
authors.affiliation: Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, Chinese Academy of Sciences and The Chinese University of Hong Kong , Hong Kong, People's Republic of China.
authors.forename: Jiewei
authors.initials: J
authors.lastname: Wu
authors.affiliation: Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, Chinese Academy of Sciences and The Chinese University of Hong Kong , Hong Kong, People's Republic of China.
authors.forename: Chunping
authors.initials: C
authors.lastname: Tang
authors.affiliation: Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, Chinese Academy of Sciences and The Chinese University of Hong Kong , Hong Kong, People's Republic of China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Yao
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, Chinese Academy of Sciences and The Chinese University of Hong Kong , Hong Kong, People's Republic of China.
authors.forename: Changqiang
authors.initials: C
authors.lastname: Ke
authors.forename: Linyin
authors.initials: L
authors.lastname: Feng
authors.affiliation: Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, Chinese Academy of Sciences and The Chinese University of Hong Kong , Hong Kong, People's Republic of China.|School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong , Shatin, NT, Hong Kong, SAR, People's Republic of China.
authors.forename: Ge
authors.initials: G
authors.lastname: Lin
authors.affiliation: Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, Chinese Academy of Sciences and The Chinese University of Hong Kong , Hong Kong, People's Republic of China.|School of Life Science and Technology, ShanghaiTech University , Shanghai 201203, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007294:Inositol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D038143:Inula / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D007294:Inositol