title: Novel Mn3 [Co(CN)6]2@SiO2@Ag Core-Shell Nanocube: Enhanced Two-Photon Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Photothermal and Chemo-therapy.
abstract: The versatile Mn3[Co(CN)6]2@SiO2@Ag core-shell NCs are prepared by a simple coprecipitation method. Ag nanoparticles with an average diameter of 12 nm deposited on the surface of Mn3[Co(CN)6]2@SiO2 through S-Ag bonding are fabricated in ethanol solution by reducing silver nitrate (AgNO3 ) with NaBH4 . The NCs possess T1 -T2 dual-modal magnetic resonance imaging ability. The inner Prussian blue analogs (PBAs) Mn3[Co(CN)6]2 exhibit bright two-photon fluorescence (TPF) imaging when excited at 730 nm. Moreover, the TPF imaging intensity displays 1.85-fold enhancement after loading of Ag nanoparticles. Besides, the sample also has multicolor fluorescence imaging ability under 403, 488, and 543 nm single photon excitation. The as-synthesized Mn3[Co(CN)6]2@SiO2@Ag NCs show a DOX loading capacity of 600 mg g(-1) and exhibit an excellent ability of near-infrared (NIR)-responsive drug release and photothermal therapy (PTT) which is induced from the relative high absorbance in NIR region. The combined chemotherapy and PTT against cancer cells in vitro test shows high therapeutic efficiency. The multimodal treatment and imaging could lead to this material a potential multifunctional system for biomedical diagnosis and therapy.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science & Engineering, CAS High Magnetic Field Laboratory, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, P. R. China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Anhui Key Laboratory for Cellular Dynamics and Chemical Biology and School of Life Sciences, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, P. R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Anhui Key Laboratory for Cellular Dynamics and Chemical Biology and School of Life Sciences, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, P. R. China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science & Engineering, CAS High Magnetic Field Laboratory, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science & Engineering, CAS High Magnetic Field Laboratory, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, P. R. China.
authors.forename: Gaozheng
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science & Engineering, CAS High Magnetic Field Laboratory, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, P. R. China.
authors.forename: Ruhui
authors.initials: R
authors.lastname: Chen
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science & Engineering, CAS High Magnetic Field Laboratory, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, P. R. China.
authors.forename: Mengni
authors.initials: M
authors.lastname: He
authors.affiliation: Anhui Key Laboratory for Cellular Dynamics and Chemical Biology and School of Life Sciences, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, P. R. China.
authors.forename: Zhenbang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Radiology Department of the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, P. R. China.
authors.forename: Haibao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science & Engineering, CAS High Magnetic Field Laboratory, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, P. R. China.
authors.forename: Qianwang
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D003035:Cobalt / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D004317:Doxorubicin; D065546:Drug Liberation; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008819:Mice, Nude; D064847:Multimodal Imaging; D061848:Optical Imaging / Q000379:methods*; D017785:Photons; D010789:Phototherapy; D012822:Silicon Dioxide / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D003486:Cyanides; C027033:hexacyanocobaltate (III); D003035:Cobalt; D008345:Manganese; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: MRI; chemotherapy; photothermal therapy; two-photon fluorescence, imaging, nanocubes