title: Prognostic value of Muc5AC in gastric cancer: A meta-analysis.
abstract: OBJECTIVE
  To assess the correlation between decreased Muc5AC expression and patients' survival and clinicopathological characteristics by conducting a meta-analysis.
  
  
  METHODS
  Literature searches were performed in PubMed and EMBASE, and 11 studies met our criteria. Summary hazard ratios or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the effect. For the pooled analysis of the correlation between decreased Muc5AC expression and clinicopathological characteristics (tumour invasion depth, lymph node metastasis, tumour-node-metastasis stage, tumour size, venous invasion and lymphatic invasion), ORs and their variance were combined to estimate the effect.
  
  
  RESULTS
  Eleven retrospective cohort studies comprising 2135 patients were included to assess the association between Muc5AC expression and overall survival and/or clinicopathological characteristics. Decreased Muc5AC expression was significantly correlated with poor overall survival of gastric cancer patients (pooled HR = 1.35, 95%CI: 1.08-1.7). Moreover, decreased Muc5AC expression was also significantly associated with tumour invasion depth (pooled OR = 2.12, 95%CI: 1.56-2.87) and lymph node metastasis (pooled OR = 1.56, 95%CI: 1.00-2.44) in gastric cancer.
  
  
  CONCLUSIONS
  Decreased Muc5AC expression might be a poor prognostic predictor for gastric cancer.
authors.affiliation: Chuan-Tao Zhang, Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Province Traditional Chinese Medicine Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Chuan-Tao
authors.initials: CT
authors.lastname: Zhang
authors.affiliation: Chuan-Tao Zhang, Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Province Traditional Chinese Medicine Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Ke-Cheng
authors.initials: KC
authors.lastname: He
authors.affiliation: Chuan-Tao Zhang, Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Province Traditional Chinese Medicine Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Pan
authors.affiliation: Chuan-Tao Zhang, Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Province Traditional Chinese Medicine Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Chuan-Tao Zhang, Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Province Traditional Chinese Medicine Hospital, Chengdu 610041, Sichuan Province, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D016009:Chi-Square Distribution; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC / Q000032:analysis*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016019:Survival Analysis; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; C524678:MUC5AC protein, human; D055271:Mucin 5AC
keywords: Gastric cancer; Muc5AC; Prognosis