title: Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease.
abstract: Autophagy is an evolutionarily-conserved process that delivers diverse cytoplasmic components to the lysosomal compartment for either recycling or degradation. This involves the removal of protein aggregates, the turnover of organelles, as well as the elimination of intracellular pathogens. In this situation, when only specific cargoes should be targeted to the lysosome, the potential targets can be selectively marked by the attachment of ubiquitin in order to be recognized by autophagy-receptors. Ubiquitination plays a central role in this process, because it regulates early signaling events during the induction of autophagy and is also used as a degradation-tag on the potential autophagic cargo protein. Here, we review how the ubiquitin-dependent steps of autophagy are balanced or counteracted by deubiquitination events. Moreover, we highlight the functional role of the corresponding deubiquitinating enzymes and discuss how they might be involved in the occurrence of cancer, neurodegenerative diseases or infection with pathogenic bacteria.
authors.affiliation: Biomedizinische Forschung, Human Brain Proteomics II, Leibniz-Institut für Analytische Wissenschaften - ISAS -e.V. 44139 Dortmund, Germany. fouzi.elmagraoui@isas.de.
authors.forename: Fouzi El
authors.initials: FE
authors.lastname: Magraoui
authors.affiliation: Biochemie Intrazellulärer Transportprozesse, Ruhr-Universität Bochum, 44801 Bochum, Germany. christina.reidick@rub.de.
authors.forename: Christina
authors.initials: C
authors.lastname: Reidick
authors.affiliation: Biomedizinische Forschung, Human Brain Proteomics II, Leibniz-Institut für Analytische Wissenschaften - ISAS -e.V. 44139 Dortmund, Germany. helmut.e.meyer@isas.de.
authors.forename: Hemut E
authors.initials: HE
authors.lastname: Meyer
authors.affiliation: Biochemie Intrazellulärer Transportprozesse, Ruhr-Universität Bochum, 44801 Bochum, Germany. harald.platta@rub.de.
authors.forename: Harald W
authors.initials: HW
authors.lastname: Platta
keywords: DUB; USP; autophagy; cancer; deubiquitination; mitophagy; neurodegeneration; ubiquitination