title: Host-Guest Interaction-Mediated Construction of Hydrogels and Nanovesicles for Drug Delivery.
abstract: Hand-in-hand or head-to-head: A novel naphthalimide derivative is successfully designed and synthesized, which can self-assemble to produce hydrogels. When injecting this compound into CB[8] solution, the nanovesicles are obtained with a narrow size distribution. The cytotoxicity assay confirms that doxorubicin-loaded nanocarriers show therapeutic effects to cancer cells.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371.
authors.forename: Xing-Dong
authors.initials: XD
authors.lastname: Xu
authors.affiliation: Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology, SE-, 10691, Stockholm, Sweden.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371.
authors.forename: Hongzhong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371.
authors.forename: Qiuyu
authors.initials: Q
authors.lastname: Qu
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371.
authors.forename: Lingzhi
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology, SE-, 10691, Stockholm, Sweden.
authors.forename: Hans
authors.initials: H
authors.lastname: Ågren
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371.|School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D016923:Cell Death / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D018613:Microscopy, Confocal; D056004:Molecular Dynamics Simulation; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D066244:Proton Magnetic Resonance Spectroscopy; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D014468:Umbelliferones / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D012996:Solutions; D014468:Umbelliferones; C031477:7-hydroxycoumarin
keywords: drug delivery; host-guest interaction; hydrogel; nanovesicle; self-assembly