title: Fresh garlic amelioration of high-fat-diet induced fatty liver in albino rats.
abstract: OBJECTIVE
  To observe the effect of fresh garlic on high-fat-diet-induced fatty liver changes.
  
  
  METHODS
  The experimental study was conducted at the Jinnah Postgraduate Medical Centre, Karachi, from October to November 2008, and comprised adult albino rats weighing 200-240g each. The rats were divided into 5 groups according to dietary regimen for eight weeks each. Group A received control diet; Group B received high saturated fat diet; Group C received high unsaturated fat diet; Group D received high saturated fat diet with fresh garlic; and Group E received high unsaturated fat diet with garlic for 8 weeks. Liver tissue slides were stained with Oil red-O and haematoxylin and Periodic acid-Schiff-haematoxylin.
  
  
  RESULTS
  The 50 rats in the study were divided into five groups of 10(20%) each. There was marked deposition of fat in hepatocyte along with marked decrease in glycogen content in liver of rats in Groups B and C, with Group B showing more marked changes. The changes in fat and glycogen content were reversed and ameliorated close to Group A in rats belonging to Groups D and E.
  
  
  CONCLUSIONS
  Fresh garlic minimised the high-fat-diet-induced fatty liver changes in rats.
authors.affiliation: Department of Anatomy, Bahria University Medical and Dental College, Karachi.
authors.forename: Aisha
authors.initials: A
authors.lastname: Qamar
authors.affiliation: Department of Anatomy, Fatima Jinnah Dental College, Karachi.
authors.forename: Asma
authors.initials: A
authors.lastname: Siddiqui
authors.affiliation: Department of Anatomy, Hamdard College of Medicine and Dentistry, Hamdard University, Karachi.
authors.forename: Hemant
authors.initials: H
authors.lastname: Kumar
mesh_terms: D000818:Animals; D002079:Butter; D003314:Corn Oil; D059305:Diet, High-Fat / Q000009:adverse effects*; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D005260:Female; D005737:Garlic; D008297:Male; D008517:Phytotherapy; D051381:Rats
chemical_list: D003314:Corn Oil; D002079:Butter
keywords: Fatty liver, SFD (saturated fat diet), UFD (unsaturated fat diet), Garlic, Glycogen.