title: Antimelanogenic Effects of Picrionoside A Isolated from the Leaves of Korean Ginseng.
abstract: This study was initiated to isolate active metabolites from the leaves of Panax ginseng. Among them, picrionoside A, a megastigmane glucoside, was isolated from the leaves of P. ginseng C. A. MAYER and its chemical structure was determined based on spectroscopic methods, including FAB-MS, one-dimensional (1D)-NMR, 2D-NMR, and IR spectroscopy. Picrionoside A from P. ginseng has not been investigated previously, and its biological or pharmaceutical activities have not been reported elsewhere. The IC50 value of mushroom tyrosinase-inhibitory activity of picrionoside A was 9.8 µM, and the rate of inhibition of synthesized melanin content in melan-a cells was 17.1% at a concentration of 80 µM without cytotoxicity. Furthermore, picrionoside A dramatically reduced body pigmentation in the zebrafish model. Taken together, the results suggest that picrionoside A isolated from the leaves of P. ginseng may be an effective skin-whitening agent that could be a potent candidate material in the cosmetic industry.
authors.affiliation: Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA.
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Lee
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Jeong
authors.forename: Yong Tae
authors.initials: YT
authors.lastname: Jeong
authors.forename: Mi-Kyoung
authors.initials: MK
authors.lastname: Lee
authors.forename: Kyeong-Hwa
authors.initials: KH
authors.lastname: Seo
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Geum-Soog
authors.initials: GS
authors.lastname: Kim
authors.forename: Seung-Eun
authors.initials: SE
authors.lastname: Lee
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000818:Animals; D002460:Cell Line; D053138:Cyclohexenes / Q000302:isolation & purification / Q000494:pharmacology*; D004625:Embryo, Nonmammalian; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D008543:Melanins / Q000378:metabolism*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D005894:Panax; D018515:Plant Leaves / Q000737:chemistry; D062327:Skin Lightening Preparations / Q000302:isolation & purification / Q000494:pharmacology*; D015027:Zebrafish
chemical_list: D053138:Cyclohexenes; D005960:Glucosides; D008543:Melanins; D062327:Skin Lightening Preparations; C000609212:picrionoside A; D014442:Monophenol Monooxygenase