title: Mature T-cell leukemias: Molecular and Clinical Aspects.
abstract: Mature T-cell leukemias are a group of uncommon lymphoid neoplasms. These disorders have widely variable clinical features, ranging from indolent, slowly progressive processes to diseases with rapidly progressive courses, leading to death. Cytogenetic aberrations have long been identified in some of these diseases, and recent studies have found recurrent genetic mutations that contribute to their pathogenesis. Conventional multiagent chemotherapy lacks significant efficacy in this group of diseases and therapies vary from immunosuppression to treatment with monoclonal antibodies, antiviral agents, and hematopoietic stem cell transplantation. The recent expansion of knowledge regarding the underlying genetic basis of these disorders raises hope that new, more targeted therapeutic approaches will be available to patients in the near future.
authors.affiliation: Department of Pathology, University of Michigan, M5242 Medical Science 1 1301 Catherine St, Ann Arbor, MI, 48109, USA. ngbailey@umich.edu.
authors.forename: Nathanael G
authors.initials: NG
authors.lastname: Bailey
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania, 422 Curie Boulevard, Philadelphia, PA, 19104, USA. Kojo.Elenitoba-Johnson@uphs.upenn.edu.
authors.forename: Kojo S J
authors.initials: KS
authors.lastname: Elenitoba-Johnson
mesh_terms: D023281:Genomics; D006801:Humans; D015458:Leukemia, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
keywords: Adult T-cell leukemia/lymphoma; Genomics; Mature T-cell leukemia; Sézary syndrome; T-cell large granular lymphocytic leukemia; T-cell prolymphocytic leukemia