title: The brain at risk: the sepsis syndrome and lessons from preclinical experiments.
abstract: There is a growing awareness of the chronic brain injury that results from the sepsis syndrome. We review experiments in several animal models of sepsis and show in one model, cecal ligation and puncture (CLP), that permanent structural pathology matures after the initial event. Specifically, we observed after exposure to CLP significant decreased spine density on the apical tree, but not the basal tree, of dendrites in the CA1 region of the dorsal hippocampus that was accompanied by a significantly diminished arbor of the apical dendrites, by 8 weeks, but not after 2 weeks. These novel data from dendritic arborizations elaborate information about a cohort of mice that had behaved in spatial memory tasks. These results raise questions about the relationship between long-term behavioral consequences and intervention strategies.
authors.affiliation: Laboratory of Biomedical Science, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA. bvolpe1@nshs.edu.|Department of Molecular Medicine, Hofstra North Shore LIJ Medical School, Hempstead, NY, USA. bvolpe1@nshs.edu.
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Volpe
authors.affiliation: Autoimmunity Center, Feinstein Institute for Medical Research, Manhasset, NY, USA.
authors.forename: Rose Ann
authors.initials: RA
authors.lastname: Berlin
authors.affiliation: Department of Science Education, Hofstra North Shore LIJ Medical School, Hempstead, NY, USA.
authors.forename: Maya
authors.initials: M
authors.lastname: Frankfurt
mesh_terms: D000818:Animals; D000067289:Behavior Observation Techniques; D020208:Brain Injury, Chronic / Q000276:immunology*; D056547:CA1 Region, Hippocampal / Q000473:pathology*; D002432:Cecum / Q000601:surgery; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D008569:Memory Disorders / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D009473:Neuronal Plasticity / Q000276:immunology; D009474:Neurons / Q000473:pathology*; D018805:Sepsis / Q000276:immunology* / Q000503:physiopathology
keywords: CA1 hippocampus; Cecal ligation and puncture; Golgi analysis; Sepsis syndrome