title: 1,6-Conjugated Addition-Mediated [2+1] Annulation: Approach to Spiro[2.5]octa-4,7-dien-6-one.
abstract: A formal 1,6-conjugated addition-mediated [2+1] annulation to synthesize spiro[2.5]octa-4,7-dien-6-one with p-quinone methides and sulfur ylides has been described. This domino-type process was highly diastereoselective and exhibited good functional group tolerance and scalability without the use of metals and bases.
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, P. R. China.
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, P. R. China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Fang
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, P. R. China.
authors.forename: Xuanyi
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, P. R. China.
authors.forename: Hequan
authors.initials: H
authors.lastname: Yao
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, P. R. China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin