title: Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells.
abstract: Tumors are metabolically heterogeneous, and subpopulations of tumorigenic cells have been recently described to rely more on mitochondrial respiration than glycolysis for energy production. In this issue, Sancho et al. (2015) demonstrate that MYC is a master switch regulating metabolic programs in different subpopulations of pancreatic tumor cells.
authors.affiliation: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: aviale@mdanderson.org.
authors.forename: Andrea
authors.initials: A
authors.lastname: Viale
authors.affiliation: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Giulio F
authors.initials: GF
authors.lastname: Draetta
mesh_terms: D000818:Animals; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors