title: Nano-Engineered Environment for Nerve Regeneration: Scaffolds, Functional Molecules and Stem Cells.
abstract: One of the most complex systems in the human body is the nervous system, which is divided into the central and peripheral nervous systems. The regeneration of the CNS is a complex and challenging biological phenomenon hindered by the low regenerative capacity of neurons and the prohibition factors in response to nerve injuries. To date, no effective approach can achieve complete recovery and fully restore the functions of the nervous system once it has been damaged. Developments in neuroscience have identified properties of the local environment with a critical role in nerve regeneration. Advances in biomaterials and biomedical engineering have explored new approaches of constructing permissive environments for nerve regeneration, thereby enabling optimism with regard to nerve-injury treatment. This article reviews recent progress in nanoengineered environments for aiding nerveinjury repair and regeneration, including nanofibrous scaffolds, functional molecules, and stem cells.
authors.forename: Liumin
authors.initials: L
authors.lastname: He
authors.forename: Lingling
authors.initials: L
authors.lastname: Tian
authors.forename: Yuqiao
authors.initials: Y
authors.lastname: Sun
authors.forename: Yongnu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
authors.forename: Kwok-Fai
authors.initials: KF
authors.lastname: So
authors.affiliation: Guangdong-Hongkong- Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou 510632, China.
authors.forename: Seeram
authors.initials: S
authors.lastname: Ramakrishna
authors.forename: Wutian
authors.initials: W
authors.lastname: Wu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D006801:Humans; D036103:Nanotechnology / Q000379:methods*; D009416:Nerve Regeneration / Q000187:drug effects; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials