title: Fatigue in chronic inflammation - a link to pain pathways.
abstract: Fatigue is a frequent symptom in several inflammatory diseases, particularly in rheumatic diseases. Elements of disease activity and cognitive and behavior aspects have been reported as causes of fatigue in patients with rheumatoid arthritis. Fatigue could be associated with activity of inflammatory rheumatism. Indeed, biologic agents targeting inflammatory cytokines are effective in fatigue. Fatigue is also associated with pain and depressive symptoms. Different pathways could be involved in fatigue and interact: the immune system with increased levels of pro-inflammatory cytokines (interleukin-1 and -6 and tumor necrosis factor alpha), dysregulation of the hypothalamic-pituitary-adrenal axis and neurological phenomena involving the central and autonomic nervous systems. A pro-inflammatory process could be involved in pain and behavioral symptoms. Inflammation could be a common link between fatigue, pain, and depression.
authors.affiliation: Department of Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital, F-75012, Paris, France.|Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Pierre & Marie Curie University Paris 06 - INSERM UMR_S 938, Paris, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Louati
authors.affiliation: Department of Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital, F-75012, Paris, France. francis.berenbaum@sat.aphp.fr.|Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Pierre & Marie Curie University Paris 06 - INSERM UMR_S 938, Paris, France. francis.berenbaum@sat.aphp.fr.
authors.forename: Francis
authors.initials: F
authors.lastname: Berenbaum
mesh_terms: D002908:Chronic Disease; D016207:Cytokines / Q000097:blood; D003863:Depression / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D005221:Fatigue / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000097:blood; D008954:Models, Biological; D010146:Pain / Q000150:complications / Q000503:physiopathology*; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators