title: Highly-efficient and versatile fluorous-tagged Cu(I)-catalyzed azide-alkyne cycloaddition ligand for preparing bioconjugates.
abstract: A novel ligand (FBTTBE) for Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) has been developed, which demonstrates not only superior catalytic efficiency but also the ease of removing toxic copper species. FBTTBE has also been successfully applied in the synthesis of radiometal-labeled peptide and antibody without observable transchelation with the non-radioactive Cu(i) catalyst.
authors.affiliation: Department of Radiology, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA. zengd@upmc.edu.
authors.forename: Lingyi
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Radiology, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA. zengd@upmc.edu.
authors.forename: Yongkang
authors.initials: Y
authors.lastname: Gai
authors.affiliation: Department of Radiology, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA. zengd@upmc.edu.
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Anderson
authors.affiliation: Department of Radiology, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA. zengd@upmc.edu.
authors.forename: Dexing
authors.initials: D
authors.lastname: Zeng
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000818:Animals; D000906:Antibodies / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D061565:Cycloaddition Reaction; D005461:Fluorine / Q000737:chemistry*; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D008024:Ligands; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000175:diagnosis; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D000480:Alkynes; D000906:Antibodies; D001386:Azides; D008024:Ligands; D009942:Organometallic Compounds; D010455:Peptides; D005461:Fluorine; D003300:Copper