title: Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction.
abstract: OBJECTIVE
  Low-T3 syndrome is common in patients with acute myocardial infarction (AMI). Recent experimental and clinical data have suggested a potential negative impact of low-T3 syndrome on myocardial function in patients with AMI. The aim of this study was to assess left ventricular (LV) myocardial function in patients with low-T3 syndrome and to investigate the association between hormonal profile and the severity of LV dysfunction using speckle-tracking echocardiography (STE).
  
  
  METHODS
  In 130 patients with first-onset ST-segment elevation acute myocardial infarction (STEMI), conventional 2D and speckle-tracking echocardiography within 48-72h after the hospitalization was performed, and blood samples for TSH, fT4, fT3, and anti-TPO levels were obtained to investigate thyroid hormone production within 24h and on the fourth day after the onset of STEMI symptoms.
  
  
  RESULTS
  The patients were divided into two groups according to their serum level of fT3: group 1 with fT3 concentration below 3.2pmol/L (n=34) and group 2 with normal fT3 (>3.2pmol/L) level (n=96). LV ejection fraction (EF) tended to be lower in the low fT3 group. The systolic longitudinal strain did not differ between the groups, but the late diastolic longitudinal strain rate was lower in group 1 (P=0.011). The systolic basal LV rotation positively correlated with the level of fT3 (r=0.4; P<0.001), while a negative correlation was detected between myocardial rotational parameters - systolic apical rotation (r=-0.2; P<0.05), torsion (r=-0.3; P<0.001), and diastolic apical rotation rate (r=-0.3; P<0.01) - and fT3 levels.
  
  
  CONCLUSIONS
  The late diastolic longitudinal LV strain rate and LV rotation evaluated by speckle-tracking echocardiography were impaired in patients with low-T3 syndrome after AMI.
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: editajank1@gmail.com.
authors.forename: Edita
authors.initials: E
authors.lastname: Jankauskienė
authors.affiliation: Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: pauliusorda@gmail.com.
authors.forename: Paulius
authors.initials: P
authors.lastname: Orda
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: egle.rumbinaite@gmail.com.
authors.forename: Eglė
authors.initials: E
authors.lastname: Rumbinaitė
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: Diana.Peksiene@lsmuni.lt.
authors.forename: Diana
authors.initials: D
authors.lastname: Žaliaduonytė-Pekšienė
authors.affiliation: Department of Laboratory Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: rasastepkons@gmail.com.
authors.forename: Rasa
authors.initials: R
authors.lastname: Steponavičiutė
authors.affiliation: Department of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: aurelija.krasauskiene@gmail.com.
authors.forename: Aurelija
authors.initials: A
authors.lastname: Krasauskienė
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: jvaskelyte@gmail.com.
authors.forename: Jolanta Justina
authors.initials: JJ
authors.lastname: Vaškelytė
authors.affiliation: Behavioral Medicine Institute, Medical Academy, Lithuanian University of Health Sciences, Palanga, Lithuania.
authors.forename: Robertas
authors.initials: R
authors.lastname: Bunevičius
mesh_terms: D000368:Aged; D003971:Diastole; D004452:Echocardiography / Q000379:methods; D005067:Euthyroid Sick Syndromes / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013318:Stroke Volume; D013599:Systole; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016277:Ventricular Function, Left
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
keywords: Acute myocardial infarction; Low-T3 syndrome; Speckle-tracking echocardiography; Systolic and diastolic left ventricular function