title: Characterisation of inflammatory processes in Helicobacter pylori-induced gastric lymphomagenesis in a mouse model.
abstract: Gastric MALT lymphoma (GML) can be induced by Helicobacter pylori infection in BALB/c mice thymectomised at day 3 post-birth (d3Tx). This represented a unique opportunity to investigate the inflammatory process involved in the recruitment, proliferation and structuration of lymphoid infiltrates in the gastric mucosa of mice developing GML. Complementary molecular and proteomic approaches demonstrated that Th1 and Th2 cytokines were upregulated, along with activators/regulators of the lymphoid response and numerous chemokines. Interleukin-4, interferon γ, lymphotoxin-α and -β were significantly upregulated and correlated with the inflammatory scores for all the d3Tx mice. GML lesions in d3Tx mice infected with H. pylori were associated with the presence of the inflammatory response. The dysregulation of numerous members of the tumour necrosis factor superfamily was also evident and suggests that they could play an important role in GML pathology, especially in light of their ability to promote and control lymphocyte proliferation.
authors.affiliation: University of Bordeaux, Bacteriology Laboratory, Bordeaux, France.|Inserm U853, Bordeaux, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Floch
authors.affiliation: University of Bordeaux, Bacteriology Laboratory, Bordeaux, France.|Inserm U853, Bordeaux, France.
authors.forename: Amandine Marine
authors.initials: AM
authors.lastname: Laur
authors.affiliation: Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Korolik
authors.affiliation: University of Bordeaux, Bacteriology Laboratory, Bordeaux, France.|Inserm U853, Bordeaux, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Chrisment
authors.affiliation: University of Bordeaux, Bordeaux, France.
authors.forename: David
authors.initials: D
authors.lastname: Cappellen
authors.affiliation: University of Bordeaux, Bordeaux, France.
authors.forename: Yamina
authors.initials: Y
authors.lastname: Idrissi
authors.affiliation: University of Bordeaux, Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Dubus
authors.affiliation: University of Bordeaux, Bacteriology Laboratory, Bordeaux, France.|Inserm U853, Bordeaux, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Mégraud
authors.affiliation: University of Bordeaux, Bacteriology Laboratory, Bordeaux, France.|Inserm U853, Bordeaux, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lehours
mesh_terms: D000818:Animals; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology*; D016480:Helicobacter pylori; D007249:Inflammation / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D016133:Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
chemical_list: D016207:Cytokines
keywords: MALT lymphoma; TNF; animal model; chemokines; cytokines