title: A comparison of volumetric modulated arc therapy and sliding-window intensity-modulated radiotherapy in the treatment of Stage I-II nasal natural killer/T-cell lymphoma.
abstract: This article is aimed to compare the dosimetric differences between volumetric modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) for Stage I-II nasal natural killer/T-cell lymphoma (NNKTL). Ten patients with Stage I-II NNKTL treated with IMRT were replanned with VMAT (2 arcs). The prescribed dose of the planning target volume (PTV) was 50Gy in 25 fractions. The VMAT plans with the Anisotropic Analytical Algorithm (Version 8.6.15) were based on an Eclipse treatment planning system; the monitor units (MUs) and treatment time (T) were scored to measure the expected treatment efficiency. All the 10 patients under the study were subject to comparisons regarding the quality of target coverage, the efficiency of delivery, and the exposure of normal adjacent organs at risk (OARs). The study shows that VMAT was associated with a better conformal index (CI) and homogeneity index (HI) (both p < 0.05) but slightly higher dose to OARs than IMRT. The MUs with VMAT (650.80 ± 24.59) were fewer than with IMRT (1300.10 ± 57.12) (relative reduction of 49.94%, p = 0.00) when using 2-Gy dose fractions. The treatment time with VMAT (3.20 ± 0.02 minutes) was shorter than with IMRT (7.38 ± 0.18 minutes) (relative reduction of 56.64%, p = 0.00). We found that VMAT and IMRT both provide satisfactory target dosimetric coverage and OARs sparing clinically. Likely to deliver a bit higher dose to OARs, VMAT in comparison with IMRT, is still a better choice for treatment of patients with Stage I-II NNKTL, thanks to better dose distribution, fewer MUs, and shorter delivery time.
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China.
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China.
authors.forename: Fu
authors.initials: F
authors.lastname: Jin
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China.
authors.forename: Mingsong
authors.initials: M
authors.lastname: Zhong
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China.
authors.forename: Huanli
authors.initials: H
authors.lastname: Luo
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China.
authors.forename: Da
authors.initials: D
authors.lastname: Qiu
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China.
authors.forename: Han
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China.
authors.forename: Guanglei
authors.initials: G
authors.lastname: He
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, PR China. Electronic address: zjajf@126.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000532:radiotherapy*; D058958:Organs at Risk; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated
keywords: Head and Neck Cancer; Intensity-modulated radiation therapy; Nasal natural killer/T-cell lymphoma; Radiation therapy; VMAT