title: Efficacy and Safety of High Specific Volume Polysaccharide-A New Type of Dietary Fiber for Treatment of Functional Constipation and IBS-C.
abstract: We investigated the efficacy and safety of a new type of dietary fiber (high specific volume polysaccharide) for use in treating constipation of different etiologies. Functional constipation patients and irritable bowel syndrome-constipation (IBS-C) patients were administrated high specific volume polysaccharide (HSVP) three times daily for a period of 2 wk to relieve their symptoms. Scores on a stool form scale, and patient reports of straining during a bowel movement, having sensations of an incomplete bowel movement or a blocked anorectum, and abnormal defecation intervals were recorded, graded, and scored by a functional constipation sample group. Similarly, a cohort of IBS-C patients reported their occurrence of abdominal discomfort or pain, abnormal stool formation, defecation frequency, and straining during a bowel movement. Additionally, both groups reported any adverse reactions associated with taking HSVP. All patients in both groups returned for follow-up visits, and no adverse reactions to treatment with HSVP were reported. In the functional constipation group, HSVP was effective for treating symptoms of constipation in 81.46% and 93.17% of patients after 7 and 14 d of dosing, respectively (both p<0.05). In the IBS-C group, symptoms of constipation were relieved in 71.67% and 88.34% of patients after 7 and 14 d of dosing, respectively (both p<0.05). High specific volume polysaccharide was shown be effective for treatment of functional constipation and IBS-C, without causing significant adverse events.
authors.affiliation: Digestive System Department, The Second Hospital of Jilin University.
authors.forename: Liang
authors.initials: L
authors.lastname: Cong
authors.forename: Jing-Ting
authors.initials: JT
authors.lastname: Ma
authors.forename: Zhen-Jing
authors.initials: ZJ
authors.lastname: Jin
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Duan
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Su
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.forename: Ling-Juan
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Jia
authors.initials: J
authors.lastname: Xu
authors.forename: Dong-Fu
authors.initials: DF
authors.lastname: Li
mesh_terms: D000328:Adult; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003672:Defecation / Q000187:drug effects*; D004043:Dietary Fiber / Q000008:administration & dosage*; D005243:Feces; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications*; D008297:Male; D011134:Polysaccharides / Q000008:administration & dosage*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D004043:Dietary Fiber; D011134:Polysaccharides