title: Feasibility of a Modified Biopsy Needle for Irreversible Electroporation Ablation and Periprocedural Tissue Sampling.
abstract: To test the feasibility of modified biopsy needles as probes for irreversible electroporation ablation and periprocedural biopsy.
  
  
  
  Core biopsy needles of 16-G/9-cm were customized to serve as experimental ablation probes. Computed tomography-guided percutaneous irreversible electroporation was performed in in vivo porcine kidneys with pairs of experimental (n = 10) or standard probes (n = 10) using a single parameter set (1667 V/cm, ninety 100 µs pulses). Two biopsy samples were taken immediately following ablation using the experimental probes (n = 20). Ablation outcomes were compared using computed tomography, simulation, and histology. Biopsy and necropsy histology were compared.
  
  
  
  Simulation-suggested ablations with experimental probes were smaller than that with standard electrodes (455.23 vs 543.16 mm2), although both exhibited similar shape. Computed tomography (standard: 556 ± 61 mm2, experimental: 515 ± 67 mm2; P = .25) and histology (standard: 313 ± 77 mm2, experimental: 275 ± 75 mm2; P = .29) indicated ablations with experimental probes were not significantly different from the standard. Histopathology indicated similar morphological changes in both groups. Biopsies from the ablation zone yielded at least 1 core with sufficient tissue for analysis (11 of the 20).
  
  
  
  A combined probe for irreversible electroporation ablation and periprocedural tissue sampling from the ablation zone is feasible. Ablation outcomes are comparable to those of standard electrodes.
authors.affiliation: Interventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA thomas.wimmer@medunigraz.at.|Division of General Radiology, Department of Radiology, Medical University of Graz, Graz, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Wimmer
authors.affiliation: Interventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Govindarajan
authors.initials: G
authors.lastname: Srimathveeravalli
authors.affiliation: Interventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Silk
authors.affiliation: Laboratory of Comparative Pathology, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, The Rockefeller University, New York, NY, USA.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Monette
authors.affiliation: Interventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Narendra
authors.initials: N
authors.lastname: Gutta
authors.affiliation: Interventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Majid
authors.initials: M
authors.lastname: Maybody
authors.affiliation: Interventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Erinjery
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Coleman
authors.affiliation: Interventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Solomon
authors.affiliation: Interventional Radiology Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Constantinos T
authors.initials: CT
authors.lastname: Sofocleous
mesh_terms: D055011:Ablation Techniques / Q000295:instrumentation* / Q000379:methods*; D000818:Animals; D001707:Biopsy, Needle / Q000295:instrumentation* / Q000379:methods*; D018274:Electroporation / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D007668:Kidney / Q000601:surgery; D009339:Needles; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods
keywords: ablation technique; computed tomography; core needle biopsy; irreversible electroporation; kidney