title: In vivo anti-inflammatory, analgesic and antipyretic activities of a medicinal plant, Caesalpinia bonducella F.
abstract: This research examined antipyretic, anti-inflammatory, and analgesic activities of ethanolic extract of C. bonducella whole seeds in experimental albino rats. Three doses, 100, 200 and 400 mg/kg of the whole seed ethanolic extract prepared as a suspension in 2 ml of 2% gum acacia were used. Acute inflammatory and antipyretic activities were evaluated in experimental animals by carrageenan induced paw edema and brewer's yeast-induced pyrexia models, respectively. A significant (p<0.05) reduction in paw volumes, and pyrexia was noted in experimental animals when compared with control animals. The ethanol see extract (400 mg/kg) displayed in vivo anti-inflammatory, antipyretic and analgesic in terms of reduction in paw edema, % writhes inhibition and rectal temperature by (0.24±0.03), (31.38%) and (36.2±0.1), respectively. Overall the whole ethanolic seed extract at all tested concentrations produced significant (p<0.05) anti-inflammatory, antipyretic and analgesic activities. The results obtained in this study clearly indicated the ethno-medicinal potential of C. bonducella in curing pain and inflammation related disorders, supporting its efficacy as a natural analgesic, antipyretic and anti-inflammatory agent.
authors.affiliation: Department of Food Science and Technology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
authors.forename: Shruti
authors.initials: S
authors.lastname: Shukla
authors.affiliation: Department of Botany, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Mehta
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D029911:Caesalpinia; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D058633:Antipyretics; D010936:Plant Extracts