title: Increased serum peroxiredoxin 5 levels in myasthenia gravis.
abstract: Extracellular peroxiredoxin 5 (PRX5) is known to be an inflammatory mediator. The serum PRX5 levels of 40 patients with anti-acetylcholine receptor antibody-positive MG and those of 40 controls were measured. PRX5 levels in patients with MG were higher than those in the controls (P=0.045). Thymoma-associated MG patients showed higher PRX5 levels than late-onset MG patients and controls (P<0.05). There were significant associations between the serum PRX5 levels and high mobility group box 1 levels. PRX5 elevation in MG could be related to the neuromuscular junction breakdown and plays a pivotal role in the pathogenic inflammation of MG.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan. Electronic address: auzawa@chiba-u.jp.
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Uzawa
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan; Department of Neurology, Neurology Chiba Clinic, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kawaguchi
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kanai
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Himuro
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Oda
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood; D005260:Female; D024243:HMGB1 Protein / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood* / Q000276:immunology / Q000503:physiopathology*; D019636:Neurodegenerative Diseases / Q000097:blood; D054464:Peroxiredoxins / Q000097:blood*; D011950:Receptors, Cholinergic / Q000276:immunology; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D015854:Up-Regulation / Q000502:physiology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; D011950:Receptors, Cholinergic; C515974:PRDX5 protein, human; D054464:Peroxiredoxins
keywords: Anti-acetylcholine receptor antibody; High mobility group box 1; Myasthenia gravis; Peroxiredoxin; Thymoma