title: Right hippocampus size is negatively correlated with leptin serum levels in bipolar disorder.
abstract: Obesity is more frequent in bipolar disorder. Adipokines are associated with depression and obesity via the inflammatory process. Twenty-six DSM-IV patients with BD and 39 controls were enrolled to assess the relationship between serum leptin and adiponectin with hippocampal volumes. Among patients, there was a significant negative correlation between right hippocampal volume and serum leptin levels. This result sum for the hypothesis of a pro-inflammatory state associated with BD and the prevalent co-morbid obesity.
authors.affiliation: Laboratory of Molecular Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; CNPq, National Institute for Translational Medicine, Porto Alegre, Brazil.
authors.forename: Miréia
authors.initials: M
authors.lastname: Vianna-Sulzbach
authors.affiliation: Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil.
authors.forename: Natalia P
authors.initials: NP
authors.lastname: Rocha
authors.affiliation: Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil.
authors.forename: Antonio Lucio
authors.initials: AL
authors.lastname: Teixeira
authors.affiliation: Laboratory of Molecular Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; CNPq, National Institute for Translational Medicine, Porto Alegre, Brazil.
authors.forename: Eduarda D
authors.initials: ED
authors.lastname: Rosa
authors.affiliation: Laboratory of Molecular Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; CNPq, National Institute for Translational Medicine, Porto Alegre, Brazil.
authors.forename: André A S
authors.initials: AA
authors.lastname: Goldani
authors.affiliation: Laboratory of Molecular Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; CNPq, National Institute for Translational Medicine, Porto Alegre, Brazil; Programa de Pos- Graduacao em Ciencias Medicas: Psiquiatria, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Marcia
authors.initials: M
authors.lastname: Kauer-Sant Anna
authors.affiliation: Laboratory of Molecular Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; CNPq, National Institute for Translational Medicine, Porto Alegre, Brazil; Programa de Pos- Graduacao em Ciencias Medicas: Psiquiatria, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. Electronic address: cgama@hcpa.edu.br.
authors.forename: Clarissa S
authors.initials: CS
authors.lastname: Gama
mesh_terms: D054392:Adipokines / Q000097:blood; D052242:Adiponectin / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010865:Pilot Projects
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin
keywords: Adipokines; Bipolar Disorder; Hippocampal volume