title: Changes in antimicrobial susceptibility patterns of Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus over the past decade.
abstract: BACKGROUND
  Development of antimicrobial resistance is an ongoing and increasing problem. To provide the best possible treatment for patients it is crucial that clinicians are aware of the local antimicrobial susceptibility patterns. The aim of this study was to present an overview of the percentage of bacterial isolates that are covered by the most commonly used antibiotics in the area of Copenhagen and to provide clinicians with a practical tool to help chose the right antimicrobial treatment for their patients.
  
  
  METHODS
  We conducted a study of all bacteria isolates tested for antimicrobial susceptibility at Hvidovre Hospital, Denmark, from 2004 to 2008. Due to a suspected rise in resistance in Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae after this period, updated data for these bacteria are shown for selected antibiotics until 2014. The department receives samples from hospitals as well as from primary healthcare. Only one isolate per species per patient per year was included.
  
  
  RESULTS
  A total of 224,033 bacteria isolates were included in this study. The antimicrobial susceptibility of the various bacteria is presented in a table. No clinically relevant changes in resistance patterns were noted up to 2014.
  
  
  CONCLUSIONS
  A comprehensive and manageable inventory of the resistance patterns of the major bacteria covering the 2004-2008 period is presented. Clinicians are encouraged to use the pocket-size table as guidance when choosing antibiotic treatment.
  
  
  BACKGROUND
  none.
  
  
  BACKGROUND
  not relevant.
authors.forename: Toke Seierøe
authors.initials: TS
authors.lastname: Barfod
authors.forename: Elisabeth Arnberg
authors.initials: EA
authors.lastname: Wibroe
authors.affiliation: julie_brauner@hotmail.com.
authors.forename: Julie Vestergaard
authors.initials: JV
authors.lastname: Braüner
authors.forename: Jenny Dahl
authors.initials: JD
authors.lastname: Knudsen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D003718:Denmark; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents