title: The Impact of Bariatric Surgery on Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis.
abstract: Bariatric surgery has been proven to be a successful management strategy for morbid obesity, but limited studies exist on its effect on polycystic ovary syndrome (PCOS). A comprehensive search of electronic databases was completed. Meta-analysis was performed on PCOS, hirsutism, and menstrual irregularity outcomes following bariatric surgery. Thirteen primary studies involving a total of 2130 female patients were identified. The incidence of PCOS preoperatively was 45.6 %, which significantly decreased to 6.8 % (P < 0.001) and 7.1 % (P < 0.0002) at 12-month follow-up and study endpoint, respectively. The incidences of preoperative menstrual irregularity and hirsutism both significantly decreased at 12-month and at study end follow-up. Bariatric surgery effectively attenuates PCOS and its clinical symptomatology including hirsutism and menstrual irregularity in severely obese women.
authors.affiliation: Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Skubleny
authors.affiliation: Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. nswitzer@ualberta.ca.|2D, Walter C Mackenzie Health Sciences Centre, University of Alberta, 840-112 Street, T6G 2B7, Edmonton, Canada. nswitzer@ualberta.ca.
authors.forename: Noah J
authors.identifier: http://orcid.org/0000-0002-9273-1008
authors.initials: NJ
authors.lastname: Switzer
authors.affiliation: Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.|Centre for the Advancement of Minimally Invasive Surgery (CAMIS), Royal Alexandra Hospital, Edmonton, Canada.
authors.forename: Richdeep S
authors.initials: RS
authors.lastname: Gill
authors.affiliation: Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Dykstra
authors.affiliation: Centre for the Advancement of Minimally Invasive Surgery (CAMIS), Royal Alexandra Hospital, Edmonton, Canada.
authors.forename: Xinzhe
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Sagle
authors.affiliation: Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.|Centre for the Advancement of Minimally Invasive Surgery (CAMIS), Royal Alexandra Hospital, Edmonton, Canada.
authors.forename: Christopher
authors.initials: C
authors.lastname: de Gara
authors.affiliation: Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.|Centre for the Advancement of Minimally Invasive Surgery (CAMIS), Royal Alexandra Hospital, Edmonton, Canada.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Birch
authors.affiliation: Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.|Centre for the Advancement of Minimally Invasive Surgery (CAMIS), Royal Alexandra Hospital, Edmonton, Canada.
authors.forename: Shahzeer
authors.initials: S
authors.lastname: Karmali
mesh_terms: D050110:Bariatric Surgery; D005260:Female; D006628:Hirsutism / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008599:Menstruation Disturbances / Q000209:etiology / Q000628:therapy*; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000628:therapy*
keywords: Bariatric surgery; Obesity; Polycystic ovary syndrome