title: High genetic abundance of Rpi-blb2/Mi-1.2/Cami gene family in Solanaceae.
abstract: BACKGROUND
  Three NBS-LRR genes, Rpi-blb2, Mi-1.2, and Cami, constitute a very special plant resistance gene family. These genes confer resistance against 4 distantly related pathogen species in 3 different Solanaceae hosts. To characterize this noted resistance, we conducted a series of studies on this gene family.
  
  
  RESULTS
  First, homologs of this gene family were identified in the pepper, tomato and potato genomes. This revealed a large variation in copy number within this gene family among species and a great divergence was found both between and within species. To gain more information pertaining to gene resistance within this family, 121 LRR regions were cloned in 16 different wild/cultivated potato accessions. Again, frequent copy number variations and a high level of divergence between homolog were observed common among accessions. The divergence within species was so high that it reaches the level of divergence between species. Also, frequent frameshift mutations and abundant gene conversion events were identified in these LRR regions.
  
  
  CONCLUSIONS
  Our findings suggest that this family harbors an unusually high level of genetic abundance, making it of particular interest. Together with other reported examples, our study also provides evidence that multi-resistance is a common trait in R gene families like this.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210000, China. swjszln0524@163.com.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Jiangsu Academy of Agricultural Sciences, Nanjing, 210000, China. 513428834@qq.com.
authors.forename: Qijun
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210000, China. rongchaogao@gmail.com.
authors.forename: Rongchao
authors.initials: R
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210000, China. sihaiyang@nju.edu.cn.
authors.forename: Sihai
authors.initials: S
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210000, China. haoxuanl@126.com.
authors.forename: Haoxuan
authors.initials: H
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210000, China. xiaohuizhang@nju.edu.cn.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhang
mesh_terms: D056915:DNA Copy Number Variations; D017343:Genes, Plant; D014644:Genetic Variation; D010802:Phylogeny; D055750:Phytophthora infestans / Q000502:physiology; D010935:Plant Diseases / Q000235:genetics* / Q000276:immunology* / Q000469:parasitology; D019657:Solanaceae / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000469:parasitology