title: Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm.
abstract: OBJECTIVE
  To demonstrate ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s for choroidal imaging in normal and diseased eyes over a ∼60° field of view. To investigate and correlate wide-field three-dimensional (3D) choroidal thickness (ChT) and vascular patterns using ChT maps and coregistered high-definition en face images extracted from a single densely sampled Megahertz-OCT (MHz-OCT) dataset.
  
  
  METHODS
  High-definition, ∼60° wide-field 3D datasets consisting of 2088 × 1024 A-scans were acquired using a 1.68 MHz prototype SS-OCT system at 1050 nm based on a Fourier-domain mode-locked laser. Nine subjects (nine eyes) with various chorioretinal diseases or without ocular pathology are presented. Coregistered ChT maps, choroidal summation maps, and depth-resolved en face images referenced to either the retinal pigment epithelium or the choroidal-scleral interface were generated using manual segmentation.
  
  
  RESULTS
  Wide-field ChT maps showed a large inter- and intraindividual variance in peripheral and central ChT. In only four of the nine eyes, the location with the largest ChT was coincident with the fovea. The anatomy of the large lumen vessels of the outer choroid seems to play a major role in determining the global ChT pattern. Focal ChT changes with large thickness gradients were observed in some eyes.
  
  
  CONCLUSIONS
  Different ChT and vascular patterns could be visualized over ∼60° in patients for the first time using OCT. Due to focal ChT changes, a high density of thickness measurements may be favorable. High-definition depth-resolved en face images are complementary to cross sections and thickness maps and enhance the interpretation of different ChT patterns.
authors.affiliation: Lehrstuhl für BioMolekulare Optik Fakultät für Physik, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Kathrin J
authors.initials: KJ
authors.lastname: Mohler
authors.affiliation: Lehrstuhl für BioMolekulare Optik Fakultät für Physik, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Draxinger
authors.affiliation: Lehrstuhl für BioMolekulare Optik Fakultät für Physik, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Klein
authors.affiliation: Lehrstuhl für BioMolekulare Optik Fakultät für Physik, Ludwig-Maximilians-Universität München, Munich, Germany 2Institut für Biomedizinische Optik, Universität zu Lübeck, Lübeck, Germany.
authors.forename: Jan Philip
authors.initials: JP
authors.lastname: Kolb
authors.affiliation: Lehrstuhl für BioMolekulare Optik Fakultät für Physik, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wieser
authors.affiliation: Augenklinik Herzog Carl Theodor, Munich, Germany.
authors.forename: Christos
authors.initials: C
authors.lastname: Haritoglou
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Anselm
authors.initials: A
authors.lastname: Kampik
authors.affiliation: Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Aljoscha S
authors.initials: AS
authors.lastname: Neubauer
authors.affiliation: Lehrstuhl für BioMolekulare Optik Fakultät für Physik, Ludwig-Maximilians-Universität München, Munich, Germany 2Institut für Biomedizinische Optik, Universität zu Lübeck, Lübeck, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Huber
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Armin
authors.initials: A
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000368:Aged; D002829:Choroid / Q000098:blood supply* / Q000473:pathology*; D015862:Choroid Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D055213:Retinal Pigment Epithelium / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*