title: Quantifying barcodes of dendritic spines using entropy-based metrics.
abstract: Spine motility analysis has become the mainstay for investigating synaptic plasticity but is limited in its versatility requiring complex, non automatized instrumentations. We describe an entropy-based method for determining the spatial distribution of dendritic spines that allows successful estimation of spine motility from still images. This method has the potential to extend the applicability of spine motility analysis to ex vivo preparations.
authors.affiliation: Institute of Genetics and Biophysics "Adriano Buzzati Traverso", CNR, Naples, 80131, Italy.|Department of Medicine and Health Sciences, Univ. Molise, Campobasso, 86100, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Viggiano
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, United Kingdom.|Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Srivastava
authors.affiliation: Institute of Genetics and Biophysics "Adriano Buzzati Traverso", CNR, Naples, 80131, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Speranza
authors.affiliation: Institute of Genetics and Biophysics "Adriano Buzzati Traverso", CNR, Naples, 80131, Italy.|Department of Pharmacy, University of Naples "Federico II", Naples, 80131, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Perrone-Capano
authors.affiliation: Institute of Genetics and Biophysics "Adriano Buzzati Traverso", CNR, Naples, 80131, Italy.
authors.forename: G C
authors.initials: GC
authors.lastname: Bellenchi
authors.affiliation: Institute of Genetics and Biophysics "Adriano Buzzati Traverso", CNR, Naples, 80131, Italy.
authors.forename: U
authors.initials: U
authors.lastname: di Porzio
authors.affiliation: Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
authors.forename: N J
authors.initials: NJ
authors.lastname: Buckley
mesh_terms: D000465:Algorithms; D000818:Animals; D003712:Dendrites; D049229:Dendritic Spines; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009473:Neuronal Plasticity; D009474:Neurons / Q000166:cytology* / Q000502:physiology*