title: Palladium-catalyzed three-component reaction of N-tosyl hydrazones, isonitriles and amines leading to amidines.
abstract: A palladium-catalyzed three-component reaction between N-tosyl hydrazones, aryl isonitriles and amines was developed, leading to amidines in moderate to good yields. This procedure features the rapid construction of amidine frameworks with high diversity and complexity. Ketenimines serve as intermediates, which encounter nucleophilic attack by amines to produce amidines.
authors.affiliation: School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou, 213164, P. R. China. jiangcheng@cczu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Dai
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Yu
authors.forename: Jiang
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000578:Amidines; D000588:Amines; D006835:Hydrazones; D009570:Nitriles; D009942:Organometallic Compounds; D010165:Palladium