title: Comparative Analysis of Prostate Volume as a Predictor of Outcome in Prostate Artery Embolization.
abstract: OBJECTIVE
  To determine the role of prostate volume as a predictor of outcome after prostatic artery embolization (PAE).
  
  
  METHODS
  From January 2012 to September 2014, 78 consecutive patients undergoing PAE were evaluated at baseline and 1, 3, and 6 months. Analysis was performed comparing prostate volume groups (group 1, < 50 cm3; group 2, 50-80 cm(3); group 3, > 80 cm3) at baseline and follow-up to assess for differences in outcomes of American Urological Association (AUA) symptom index, quality of life (QOL)-related symptoms, and International Index of Erectile Function (IIEF).
  
  
  RESULTS
  Mean baseline prostate volumes were 37.5 cm(3) in group 1 (n = 16), 65.7 cm3 in group 2 (n = 26), and 139.4 cm3 in group 3 (n = 36). There were no significant differences in baseline age, AUA symptom index, QOL, or IIEF between groups. Bilateral embolization was successful in 75 of 78 patients (96%). Two patients underwent unilateral embolization, and treatment failed in one patient as a result of bilateral atherosclerotic occlusion. A significant reduction in AUA symptom index was achieved within groups from baseline to 1, 3, and 6 months (n = 77): in group 1, from 27.2 to 14.0, 12.9, and 15.9, respectively (P = .002); in group 2, from 25.6 to 17.1, 16.3, and 13.5, respectively (P < .0001); and in group 3, from 26.5 to 15.2, 12.5, and 13.6, respectively (P < .0001). There was also a significant improvement in QOL. Comparative analysis demonstrated no statistically significant differences in AUA symptom index, QOL, or IIEF between groups. Two minor complications occurred: groin hematoma and a urinary tract infection.
  
  
  CONCLUSIONS
  PAE offers similar clinical benefits to patients with differing gland sizes and may offer a reasonable alternative for poor candidates for urologic surgery.
authors.affiliation: Department of Cardiovascular and Interventional Radiology, Association of Alexandria Radiologists,Alexandria, Virginia.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Bagla
authors.affiliation: MedStar Georgetown University Hospital, Department of Medicine 3800 Reservoir Rd. NW, Washington, DC 20007. Electronic address: sandeep.bagla@gmail.com.
authors.forename: John B
authors.initials: JB
authors.lastname: Smirniotopoulos
authors.affiliation: Department of Cardiovascular and Interventional Radiology, Association of Alexandria Radiologists,Alexandria, Virginia.
authors.forename: Julie C
authors.initials: JC
authors.lastname: Orlando
authors.affiliation: Department of Cardiovascular and Interventional Radiology, Association of Alexandria Radiologists,Alexandria, Virginia.
authors.forename: Arletta
authors.initials: A
authors.lastname: van Breda
authors.affiliation: Department of Cardiovascular and Interventional Radiology, Association of Alexandria Radiologists,Alexandria, Virginia.
authors.forename: Venu
authors.initials: V
authors.lastname: Vadlamudi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000473:pathology* / Q000628:therapy*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome