title: Benzophenone and its analogs bind to human glyoxalase 1.
abstract: Benzophenone is a popular photophore for photoaffinity-labeling. It is also an important framework for drug development; many drugs contain benzophenone or analogous frameworks. The current work reports that benzophenone and its analogs bind to human glyoxalase 1. The binding, however, has little effect on the catalytic activity of this enzyme. The implications of the finding in terms of both drug development and photoaffinity-labeling are discussed.
authors.affiliation: Department of Chemistry, Hunter College and The CUNY Graduate Center, 695 Park Avenue, New York, NY 10065, USA.
authors.forename: Doina M
authors.initials: DM
authors.lastname: Mihai
authors.affiliation: Department of Chemistry, Hunter College and The CUNY Graduate Center, 695 Park Avenue, New York, NY 10065, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Hall
authors.affiliation: School of Life Sciences, Tsinghua University, Haidian District, Beijing 100084, China.
authors.forename: Haiteng
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Process & Analytical Chemistry, Merck & Co., Inc., Rahway, NJ 07065, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Welch
authors.affiliation: Department of Chemistry, Hunter College and The CUNY Graduate Center, 695 Park Avenue, New York, NY 10065, USA.
authors.forename: Akira
authors.initials: A
authors.lastname: Kawamura
mesh_terms: D001577:Benzophenones / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000378:metabolism*; D015394:Molecular Structure; D011485:Protein Binding
chemical_list: D001577:Benzophenones; C047723:benzophenone; D007791:Lactoylglutathione Lyase
keywords: Doxorubicin; Fenofibrate; GLO1; Ketoprofen; Off-target; Photoaffinity-labeling