title: The Evidence-Based Approach to Adult-Onset Idiopathic Nephrotic Syndrome.
abstract: Adult-onset nephrotic syndrome (NS) differs from its pediatric counterpart in several important ways. Most importantly, NS in adults is more etiologically heterogeneous compared to children, and thus treatment approaches rely heavily on the histological diagnosis provided by renal biopsy. The evidence-based approach to treatment of adult NS has been critically examined by the Kidney Disease Improving Global Outcomes (KDIGO) guidelines in glomerulonephritis, published in 2012. Here, we examine the strengths and limits of those guidelines and review recent work that expands the evidence-based approach.
authors.affiliation: Division of Nephrology, Department of Medicine, Columbia University Medical Center, Columbia University College of Physicians and Surgeons , New York, NY , USA.
authors.forename: Pietro A A
authors.initials: PA
authors.lastname: Canetta
authors.affiliation: Division of Nephrology, Department of Medicine, Columbia University Medical Center, Columbia University College of Physicians and Surgeons , New York, NY , USA.
authors.forename: Jai
authors.initials: J
authors.lastname: Radhakrishnan
keywords: KDIGO guidelines; clinical practice guidelines; focal segmental glomerulosclerosis; minimal-change disease; nephrotic syndrome