title: Serum Fatty Acid Binding Protein 4 Concentrations Are Positively and Independently Associated with Blood Pressure and Abdominal Fat among Parameters in Health Check-Ups in Ordinary Middle-Aged Japanese Males.
abstract: We wished to examine potential associations among blood concentrations of fatty acid-binding protein (FABP) 4 and parameters in health check-ups such as abdominal fat area (AFA) and blood pressure (BP) in middle-aged Japanese males. We conducted a cross-sectional study of males who participated in health check-ups in Japan. We excluded participants diagnosed with metabolic diseases by the time of their check-up. A total of 305 subjects (30-64 [mean±standard deviation, 47.3±8.5] y) were recruited. Areas of total-abdominal, visceral and subcutaneous fat were measured using computed tomography. We compared the association of serum concentrations of FABP4 with various clinical parameters by Pearson product-moment correlation coefficient (PPMCC) analyses, and by step-wise multivariate linear regression analyses (MLRA). PPMCC analyses showed that blood concentrations of FABP4 were positively associated with: body mass index; areas of fat (total abdominal, visceral, subcutaneous); systolic BP; diastolic BP; total cholesterol; low-density lipoprotein-cholesterol; triacylglycerol; activities of γ-glutamyl transpeptidase, aspartate aminotransferase and alanine aminotransferase; white blood cell count; and levels of creatinine. Step-wise MLRA showed that AFAs (visceral and subcutaneous) and diastolic BP were positively and independently associated with serum concentrations of FABP4 among the parameters tested. These data suggest that serum concentrations of FABP4 are independently and positively associated with BP and AFA among parameters measured in health check-ups in middle-aged Japanese males.
authors.affiliation: Laboratory of Nutritional Physiology, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences.
authors.forename: Masami
authors.initials: M
authors.lastname: Yamada
authors.forename: Kazuki
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Kazue
authors.initials: K
authors.lastname: Honma
authors.forename: Rie
authors.initials: R
authors.lastname: Miyauchi
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Kasezawa
authors.forename: Kazushige
authors.initials: K
authors.lastname: Tohyama
authors.forename: Toshinao
authors.initials: T
authors.lastname: Goda
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D006801:Humans; D007564:Japan; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010808:Physical Examination / Q000379:methods*; D000637:Transaminases / Q000097:blood; D014280:Triglycerides / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D014280:Triglycerides; D002784:Cholesterol; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D000637:Transaminases; D000410:Alanine Transaminase