title: Role of stem cells in spondyloarthritis: Pathogenesis, treatment and complications.
abstract: Spondyloarthritis (SpA) is a family of interrelated inflammatory arthritis that includes ankylosing spondylitis (AS), psoriatic arthritis, reactive arthritis, arthritis related to inflammatory bowel disease and undifferentiated SpA. The classification, epidemiology, pathogenesis and treatment of SpA have been extensively reviewed in the published literature. Reviews on the use of stem cells in various autoimmune diseases in general are also common. However, a review on the role of stem cells in SpA is currently lacking. This review focuses on the involvement of stem cells in the pathogenesis of SpA and the application of different types of stem cells in the treatment of SpA. It also addresses some of the complications which may arise as a result of the use of stem cells in the treatment of SpA.
authors.affiliation: Faculty of Medicine, SEGi University, No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia. Electronic address: rebeccawongsy@gmail.com.
authors.forename: Rebecca S Y
authors.initials: RS
authors.lastname: Wong
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D018501:Antirheumatic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D019653:Myeloablative Agonists / Q000627:therapeutic use; D010006:Osteoblasts / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D012720:Severity of Illness Index; D025241:Spondylarthritis / Q000276:immunology / Q000473:pathology* / Q000628:therapy
chemical_list: D018501:Antirheumatic Agents; D016207:Cytokines; D019653:Myeloablative Agonists
keywords: Complications; Pathogenesis; Spondyloarthritis; Stem cells; Treatment