title: A New C23 Steroid from the Venom of Bufo bufo gargarizans.
abstract: A new C23 steroid, (3β,5β,14β)-methyl (3-hydroxy-14,15-epoxy-20-oxo-21-norcholan-24-oate) (1), together with four known ones (2-5), were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated on the basis of extensive spectroscopic analysis. The cytotoxicity of these compounds was also evaluated against human hepatocarcinoma HepG2 cells. Compound 3 showed significant cytotoxicity with an IC50 value of 16.8 +/- 0.7 μM.
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Luo
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Tian
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000664:Amphibian Venoms / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002023:Bufo bufo; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000664:Amphibian Venoms; D000970:Antineoplastic Agents; D013256:Steroids