title: Circulating concentration of markers of angiogenic activity in patients with sarcoidosis and idiopathic pulmonary fibrosis.
abstract: BACKGROUND
  Angiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases. The aim of the study was to compare the angiogenic profile of patients with sarcoidosis and idiopathic pulmonary fibrosis (IPF) based on analysis of circulating factors.
  
  
  METHODS
  Serum concentrations of angiopoietin-2 (Ang-2), follistatin, granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin-8 (IL-8), platelet derived growth factor-BB (PDGF-BB), platelet endothelial cellular adhesion molecule-1 (PECAM-1) and vascular endothelial growth factors (VEGF) were measured in the patients and the healthy subjects.
  
  
  RESULTS
  Serum concentrations of G-CSF, follistatin, PECAM-1 and IL-8 were significantly higher in the IPF patients in comparison with the control group and the sarcoid patients. PDGF-BB concentrations were also significantly higher in serum of IPF patients than in sarcoid patients, but not than in the controls. In contrast, Ang-2 and VEGF concentrations did not differ significantly between the three groups. In the sarcoid patients, irrespective of the disease activity or the radiological stage, serum concentrations of these cytokines were similar to the control group.
  
  
  CONCLUSIONS
  These results indicate that differences may exist in angiogenic activity between patients with parenchymal lung diseases. In contrast to sarcoidosis, IPF is characterized by a higher serum concentration of different molecules involved in the angiogenic processes .
authors.affiliation: Department of Lung Diseases and Tuberculosis, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. zioradar@wp.pl.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Ziora
authors.affiliation: Department of Lung Diseases and Tuberculosis, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. darekjdr@poczta.onet.pl.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Jastrzębski
authors.affiliation: Department of Thoracic Surgery, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. m.adamek@e.pl.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Adamek
authors.affiliation: Department of Immunology and Microbiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. zczuba@sum.edu.pl.
authors.forename: Zenon
authors.initials: Z
authors.lastname: Czuba
authors.affiliation: Department of Lung Diseases and Tuberculosis, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. ftpulmza@sum.edu.pl.
authors.forename: Jerzy J
authors.initials: JJ
authors.lastname: Kozielski
authors.affiliation: Department of Internal Diseases, Dermatology and Allergology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. alicjag@mp.pl.
authors.forename: Alicja
authors.initials: A
authors.lastname: Grzanka
authors.affiliation: Department of Internal Diseases, Dermatology and Allergology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. alakasperska@gmail.com.
authors.forename: Alicja
authors.initials: A
authors.lastname: Kasperska-Zajac
mesh_terms: D000328:Adult; D000077214:Becaplermin; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D038681:Follistatin / Q000097:blood; D005541:Forced Expiratory Volume; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000097:blood*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood; D020574:Proto-Oncogene Proteins c-sis / Q000097:blood; D012507:Sarcoidosis / Q000097:blood; D017565:Sarcoidosis, Pulmonary / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood; D033921:Vesicular Transport Proteins / Q000097:blood; D014797:Vital Capacity
chemical_list: D015415:Biomarkers; C508606:CXCL8 protein, human; D038681:Follistatin; D016209:Interleukin-8; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D020574:Proto-Oncogene Proteins c-sis; C555023:VPS51 protein, human; D042461:Vascular Endothelial Growth Factor A; D033921:Vesicular Transport Proteins; D000077214:Becaplermin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor