title: Alpha-Lipoic Acid Attenuates Oxidative Damage in Organs After Sepsis.
abstract: Sepsis progression is linked with the imbalance between reactive oxygen species and antioxidant enzymes. Thus, the aim of this study was to evaluate the effect of alpha-lipoic acid (ALA), a powerful antioxidant, in organs of rats submitted to sepsis. Male Wistar rats were subjected to sepsis by cecal ligation puncture (CLP) and treated with ALA or vehicle. After CLP (12 and 24 h), the myeloperoxidase (MPO) activity, protein and lipid oxidative damage, and antioxidant enzymes in the liver, kidney, heart, and lung were evaluated. ALA was effective in reducing MPO activity, lipid peroxidation in the liver, and protein carbonylation only in the kidney in 12 h after CLP. In 12 h, SOD activity increased in the kidney and CAT activity in the liver and kidney with ALA treatment. Thus, ALA was able to reduce the inflammation and oxidative stress in the liver and kidney after sepsis in rats.
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory-FICEXP, Graduate Program in Health Sciences, University of South Santa Catarina, Avenida José Acácio Moreira, 787, 88704-900, Tubarão, SC, Brazil. fabricia.petronilho@unisul.br.
authors.forename: Fabricia
authors.initials: F
authors.lastname: Petronilho
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory-FICEXP, Graduate Program in Health Sciences, University of South Santa Catarina, Avenida José Acácio Moreira, 787, 88704-900, Tubarão, SC, Brazil.
authors.forename: Drielly
authors.initials: D
authors.lastname: Florentino
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory-FICEXP, Graduate Program in Health Sciences, University of South Santa Catarina, Avenida José Acácio Moreira, 787, 88704-900, Tubarão, SC, Brazil.
authors.forename: Lucinéia Gainski
authors.initials: LG
authors.lastname: Danielski
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory-FICEXP, Graduate Program in Health Sciences, University of South Santa Catarina, Avenida José Acácio Moreira, 787, 88704-900, Tubarão, SC, Brazil.
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Vieira
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory-FICEXP, Graduate Program in Health Sciences, University of South Santa Catarina, Avenida José Acácio Moreira, 787, 88704-900, Tubarão, SC, Brazil.
authors.forename: Maryane Modolon
authors.initials: MM
authors.lastname: Martins
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory-FICEXP, Graduate Program in Health Sciences, University of South Santa Catarina, Avenida José Acácio Moreira, 787, 88704-900, Tubarão, SC, Brazil.
authors.forename: Andriele
authors.initials: A
authors.lastname: Vieira
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory-FICEXP, Graduate Program in Health Sciences, University of South Santa Catarina, Avenida José Acácio Moreira, 787, 88704-900, Tubarão, SC, Brazil.
authors.forename: Sandra
authors.initials: S
authors.lastname: Bonfante
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory-FICEXP, Graduate Program in Health Sciences, University of South Santa Catarina, Avenida José Acácio Moreira, 787, 88704-900, Tubarão, SC, Brazil.
authors.forename: Mariana Pereira
authors.initials: MP
authors.lastname: Goldim
authors.affiliation: Experimental Pathophysiology Laboratory-FISIOPAT, Graduate Program in Health Sciences, University of Southern of Santa Catarina, Criciuma, SC, Brazil.
authors.forename: Francieli
authors.initials: F
authors.lastname: Vuolo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism; D002432:Cecum / Q000601:surgery; D007249:Inflammation / Q000188:drug therapy; D007668:Kidney / Q000201:enzymology / Q000473:pathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008168:Lung / Q000201:enzymology / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D020556:Neutrophil Infiltration / Q000187:drug effects / Q000276:immunology; D018384:Oxidative Stress / Q000187:drug effects*; D009195:Peroxidase / Q000378:metabolism; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D018805:Sepsis / Q000276:immunology / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism; D008063:Thioctic Acid / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D008063:Thioctic Acid; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase
keywords: alpha-lipoic acid; organ failure; oxidative damage; sepsis