title: Impact of left ventricular function on health-related quality of life in coronary artery disease patients.
abstract: OBJECTIVE
  The aim of the study was to investigate the relation between health-related quality of life (HRQoL) and left ventricular systolic and diastolic function parameters in stable coronary artery disease (CAD) patients with mild and moderate heart failure.
  
  
  METHODS
  This study included 758 CAD patients. Left ventricular ejection fraction (LVEF) and ratio of peak velocities of early (E) and late (A) diastolic mitral inflow, ratio E/A, deceleration time, isovolumic relaxation time were assessed. Patients completed the SF-36 questionnaire.
  
  
  RESULTS
  There were no strong and significant associations between echocardiographic measures and HRQoL in NYHA I-II class patients. In NYHA III class in univariate linear regression analyses significant associations were found between LVEF and physical functioning (β=0.230, P=0.009) and role limitations due to physical problems (β=0.230, P=0.009) and these associations remain significant after adjustment for age, gender, hypertension, angina pectoris class, nitrate, ACE inhibitors and diuretics use. E/A ratio was significantly associated only with mental health domain (β=0.188, P=0.048), and this association remains significant after all adjustments.
  
  
  CONCLUSIONS
  In stable CAD patients with NYHA I-II functional class HRQoL was not strongly associated with left ventricular function; in NYHA III functional class patients' greater systolic function mainly was associated with better physical health and better diastolic function, with better mental health.
authors.affiliation: Behavioral Medicine Institute, Medical Academy, Lithuanian University of Health Sciences, Palanga, Lithuania.
authors.forename: Margarita
authors.initials: M
authors.lastname: Staniūtė
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Vaškelytė
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Eglė
authors.initials: E
authors.lastname: Rumbinaitė
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Birutė
authors.initials: B
authors.lastname: Kaminskaitė
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Sigita
authors.initials: S
authors.lastname: Samsanavičienė
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Sigita
authors.initials: S
authors.lastname: Plungienė
authors.affiliation: Behavioral Medicine Institute, Medical Academy, Lithuanian University of Health Sciences, Palanga, Lithuania. Electronic address: jbro@ktl.mii.lt.
authors.forename: Julija
authors.initials: J
authors.lastname: Brožaitienė
authors.affiliation: Behavioral Medicine Institute, Medical Academy, Lithuanian University of Health Sciences, Palanga, Lithuania.
authors.forename: Robertas
authors.initials: R
authors.lastname: Bunevičius
mesh_terms: D000787:Angina Pectoris / Q000150:complications; D003324:Coronary Artery Disease / Q000150:complications / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D011788:Quality of Life; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D016277:Ventricular Function, Left
keywords: Coronary artery disease; Health-related quality of life; Left ventricular function