title: Thyroid function and autoimmunity during ovarian stimulation for intracytoplasmic sperm injection.
abstract: The aim of the present study was to assess changes in thyroid function and thyroid autoimmunity (TAI) throughout ovarian stimulation (OS) for intracytoplasmic sperm injection (ICSI) and the association of these changes with ICSI outcome. A flexible gonadotrophin-releasing hormone (GnRH) antagonist protocol was used in 42 women and their thyroid function and TAI were assessed at baseline and five times during OS (Days 3 and 5 of the menstrual cycle, the day of hCG administration, the day of ovum pick-up and the day of the pregnancy test). The primary outcome measure was the change in thyroid function throughout OS. No overall change was recorded in thyrotropin-stimulating hormone (TSH) concentrations throughout OS (P=0.066). In women who became pregnant (n=8), an increase in TSH concentrations was noted on the day of the pregnancy test compared with Day 3 of the menstrual cycle (3.410±1.200 vs 2.014±0.950μIU mL-1, respectively; P=0.001; mean ± s.d.). TAI was present in 11 of 42 women. Biochemical pregnancy was negatively correlated with changes in TSH (r=-0.7, P=0.004). No such association was noted regarding the live birth rate. The present study provides evidence that TSH concentrations could increase during OS, especially in women who become pregnant.
authors.affiliation: Unit of Reproductive Endocrinology and Unit of Human Reproduction, First Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki, Greece.
authors.forename: Gesthimani
authors.initials: G
authors.lastname: Mintziori
authors.affiliation: Unit of Reproductive Endocrinology and Unit of Human Reproduction, First Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki, Greece.
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Goulis
authors.affiliation: Unit of Reproductive Endocrinology and Unit of Human Reproduction, First Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki, Greece.
authors.forename: Efstratios M
authors.initials: EM
authors.lastname: Kolibianakis
authors.affiliation: Department of Biochemistry, Hormone Assay Laboratory, Hippokration Hospital, Thessaloniki, Greece.
authors.forename: Aristidis
authors.initials: A
authors.lastname: Slavakis
authors.affiliation: Unit of Reproductive Endocrinology and Unit of Human Reproduction, First Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki, Greece.
authors.forename: Julia
authors.initials: J
authors.lastname: Bosdou
authors.affiliation: Unit of Reproductive Endocrinology and Unit of Human Reproduction, First Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki, Greece.
authors.forename: Grigorios
authors.initials: G
authors.lastname: Grimbizis
authors.affiliation: Unit of Reproductive Endocrinology and Unit of Human Reproduction, First Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki, Greece.
authors.forename: Basil C
authors.initials: BC
authors.lastname: Tarlatzis
mesh_terms: D000328:Adult; D015551:Autoimmunity / Q000502:physiology*; D001723:Birth Rate; D005260:Female; D006801:Humans; D050498:Live Birth; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin