title: Assessment of Directly Observed Therapy (DOT) following tuberculosis regimen change in Addis Ababa, Ethiopia: a qualitative study.
abstract: BACKGROUND
  Tuberculosis remains a major public health problem in Ethiopia. In 2010 the TB treatment regimen was shortened from 8 to 6-months treatment. With this new regimen, the full course of treatment should be taken under Directly Observed Therapy (DOT) unlike the 8-month regimen where TB patients were only observed during the intensive phase, this has not been tried before and may be difficult to implement. Therefore this study aimed to investigate the experiences from both TB patients and health care providers' perspective of implementing DOT for the full course of TB treatment.
  
  
  METHODS
  Qualitative study consisted of 11 in-depth interviews and 4 Focus Group Discussions (FDGs) were conducted between March and April, 2014. Overall, 18 TB patients and 16 HCPs were involved from three selected public health facilities (2 Health Centers and 1 Hospital) in Addis Ababa, Ethiopia. Qualitative data analysis software (Open Code Version 3.5) was employed to identify the key issues from these interviews through coding, categorization and grouping into emergent themes.
  
  
  RESULTS
  Participants reported that making a daily visit to health facilities for DOT was difficult due to the distance of the facilities from their residences, lack of or high transportation cost and had undesired implications on their work and social lives. TB patients had to overcome many challenges to comply with TB treatment on a daily basis. HCPs also indicated the difficulties of implementing facility based daily DOT mainly due the implication it had on their TB patients and stated DOT had not always been implemented for the full course as recommended. HCPs also shared deep concern regarding the risk of acquiring multiple drug resistant TB.
  
  
  CONCLUSIONS
  This study indicated there are several challenges associated with facility based daily DOT as a method of TB treatment supervision in public health facilities in Addis Ababa. This may be indicative of the situation in other health facilities in Addis Ababa as well as elsewhere in the country. Hence the TB control program has to explore how best to improve TB treatment delivery options to ensure adequate treatment. A more patient-centered approach could be strengthened by further decentralizing the DOT to the community level in order to ensure adherence of patients to their TB treatment.
authors.affiliation: Tuberculosis research advisory committee of the Federal Ministry of Health, Addis Ababa, Ethiopia. danielfsh3@gmail.com.|KNCV Tuberculosis Foundation, Challenge TB, Country Office, Addis Ababa, Ethiopia. danielfsh3@gmail.com.
authors.forename: Daniel
authors.initials: D
authors.lastname: Fiseha
authors.affiliation: Addis Continental Institute of Public Health, Addis Ababa, Ethiopia. meazademissie@gmail.com.
authors.forename: Meaza
authors.initials: M
authors.lastname: Demissie
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D023801:Directly Observed Therapy; D005002:Ethiopia; D005260:Female; D017144:Focus Groups; D006268:Health Facilities; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D036301:Qualitative Research; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents