title: Brain Amyloid Deposition Is Associated With Lower Instrumental Activities of Daily Living Abilities in Older Adults. Results From the MAPT Study.
abstract: BACKGROUND
  Brain amyloid deposition is one of the key pathological hallmarks underlying the cognitive changes associated with Alzheimer's disease. Growing interest has been given to the earliest clinical manifestations of amyloid plaques. However, the relationship between amyloid status and activities of everyday function remains largely unknown. In the present study, we examined the relationship between instrumental activities of daily living performance (using the ADL-PI score) and amyloid status in older adults.
  
  
  METHODS
  Cross-sectional analyses of data from the Multidomain Alzheimer Preventive Trial (MAPT) were performed. Volunteers underwent a brain 18F-AV45 positron emission tomography examination. Bivariate analysis and regression models were conducted to study the relationships between brain amyloid deposition and the total ADL-PI score.
  
  
  RESULTS
  We included 271 participants (women = 60%; age = 76±4 years). Amyloid positron emission tomography was positive (standard uptake value ≥1.17) for 103 participants (38%). The ADL-PI score was lower in amyloid positive participants than in their amyloid negative counterparts (38.8 vs 40.3, p = .007). This association was also confirmed in regression models adjusted for age, gender, and familial history of Alzheimer's disease (odds ratio = 0.94; 95% confidence interval 0.89-0.99; p = .02). This finding was consistent in cognitively normal individuals and in those with mild cognitive impairment, using the clinical dementia rating scale.
  
  
  CONCLUSIONS
  This study highlighted an association between early functional limitations and brain amyloid deposition in elderly subjects. These symptoms could be the clinical manifestations of amyloid plaques even in the absence of overt dementia. Further prospective studies are warranted for examining the evolution of ADL-PI score over the course of Alzheimer's disease.
authors.affiliation: Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France. APHP, Department of Geriatrics, Bichat Hospital, Paris, France. INSERM UMR 1027, Toulouse, France. Doctoral School of Public Health - ED420, Paris-Sud University, France. mlilamand@hotmail.fr.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Lilamand
authors.affiliation: Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France. INSERM UMR 1027, Toulouse, France. University Paul Sabatier Toulouse III, France.
authors.forename: Matteo
authors.initials: M
authors.lastname: Cesari
authors.affiliation: Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France. Department of Psychiatry, University of Cambridge.
authors.forename: Natalia
authors.initials: N
authors.lastname: del Campo
authors.affiliation: Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France. INSERM UMR 1027, Toulouse, France. University Paul Sabatier Toulouse III, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Cantet
authors.affiliation: Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France. INSERM UMR 1027, Toulouse, France. University Paul Sabatier Toulouse III, France.
authors.forename: Maria
authors.initials: M
authors.lastname: Soto
authors.affiliation: Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France. INSERM UMR 1027, Toulouse, France. University Paul Sabatier Toulouse III, France.
authors.forename: Pierre-Jean
authors.initials: PJ
authors.lastname: Ousset
authors.affiliation: Nuclear Medicine Department, CHU Purpan, Toulouse, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Payoux
authors.affiliation: INSERM UMR 1027, Toulouse, France. University Paul Sabatier Toulouse III, France. Department of Public Health, CHU Toulouse, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Andrieu
authors.affiliation: Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France. INSERM UMR 1027, Toulouse, France. University Paul Sabatier Toulouse III, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease; D000682:Amyloid / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000378:metabolism*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011446:Prospective Studies
chemical_list: D000682:Amyloid
keywords: ADL-PI.; Alzheimer’s disease; Amyloid plaques; PET imaging