title: Targeting Treg signaling for the treatment of autoimmune diseases.
abstract: Regulatory T (Treg) cells are crucial players in the prevention of autoimmunity. Treg lineage commitment and functional stability are influenced by selected extracellular signals from the local environment, shaped by distinctive intracellular signaling network, and secured by their unique epigenetic profile. Recent advances in our understanding of the complex processes of Treg lineage differentiation, maintenance, and function has paved the way for developing strategies to manipulate these important cells for therapeutic benefit in many diseases. In this review, we will summarize recent advances in our understanding of Treg biology as well as Treg-targeted therapies in the context of autoimmune disease.
authors.affiliation: Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Allyson
authors.initials: A
authors.lastname: Spence
authors.affiliation: Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Joanna E
authors.initials: JE
authors.lastname: Klementowicz
authors.affiliation: UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: jeff.bluestone@ucsf.edu.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Bluestone
authors.affiliation: Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: qizhi.tang@ucsf.edu.
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Tang
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D002454:Cell Differentiation; D060833:Cellular Microenvironment; D044127:Epigenesis, Genetic; D006801:Humans; D007167:Immunotherapy; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*