title: Basal cell carcinoma of the skin (part 1): epidemiology, pathology and genetic syndromes.
abstract: Basal cell carcinoma (BCC) is the most common skin cancer worldwide with increasing incidence, but difficult to assess due to the current under registration practice. Despite the low mortality rate, BCC is a cause of great morbidity and an economic burden to health services. There are several risk factors that increase the risk of BCC and partly explain its incidence. Low-penetrance susceptibility alleles, as well as genetic alterations in signaling pathways, namely SHH pathway, also contribute to the carcinogenesis. BCC associate with several genetic syndromes, of which basal cell nevus syndrome is the most common.
authors.affiliation: Faculty of Medicine, Porto University, 4099-002 Porto, Portugal.
authors.forename: Tiago Ribeiro
authors.initials: TR
authors.lastname: Correia de Sá
authors.affiliation: Faculty of Medicine, Porto University, 4099-002 Porto, Portugal.
authors.forename: Roberto
authors.initials: R
authors.lastname: Silva
authors.affiliation: Faculty of Medicine, Porto University, 4099-002 Porto, Portugal.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Lopes
mesh_terms: D000818:Animals; D001478:Basal Cell Nevus Syndrome / Q000235:genetics / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008019:Life Style; D012307:Risk Factors; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism*
keywords: basal cell carcinoma; basal cell nevus syndrome; epidemiology; genetics; pathology