title: Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats.
abstract: OBJECTIVE
  The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology.
  
  
  METHODS
  In the present study, arsenic in the form of sodium arsenite was administered orally to male Charles Foster rats for 45 days. Thereafter, ethanolic root extract of Withania somnifera was administered for 30 days to observe its ameliorative effect on male reproductive system.
  
  
  RESULTS
  The study revealed that after administration of sodium arsenite, there was a decrease in the sperm counts and sperm motility accompanied by an increased incidence of sperm abnormalities and hormonal imbalance leading to infertility. However, after administration of Withania somnifera, there was significant reversal in the parameters denoting that it not only possesses antioxidant and rejuvenating property but also maintains the cellular integrity of testicular cells leading to normal functioning of it.
  
  
  CONCLUSIONS
  The study concludes that Withania somnifera possesses phytoremedial effect. It is one of the best antidotes against arsenic-induced reproductive toxicity.
authors.affiliation: Mahavir Cancer Institute & Research Centre, Patna, Bihar, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Mahavir Cancer Institute & Research Centre, Patna, Bihar, India.
authors.forename: Ranjit
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Mahavir Cancer Institute & Research Centre, Patna, Bihar, India.
authors.forename: Mohammad Samuir
authors.initials: MS
authors.lastname: Rahman
authors.affiliation: Mahavir Cancer Institute & Research Centre, Patna, Bihar, India.
authors.forename: Mohammad Asif
authors.initials: MA
authors.lastname: Iqubal
authors.affiliation: Mahavir Cancer Institute & Research Centre, Patna, Bihar, India.
authors.forename: Gautam
authors.initials: G
authors.lastname: Anand
authors.affiliation: Mahavir Cancer Institute & Research Centre, Patna, Bihar, India.
authors.forename: Pintoo Kumar
authors.initials: PK
authors.lastname: Niraj
authors.affiliation: Mahavir Cancer Institute & Research Centre, Patna, Bihar, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ali
keywords: Rats; Sodium arsenite; Sperm Count; Testicular toxicity; Testosterone; W. somnifera