title: A rare case of concomitant tuberculosis of the nose, paranasal sinuses and larynx: clinical, histological and immunohistochemical aspects. A case report.
abstract: Extrapulmonary tuberculosis is a rare condition determined by Mycobacterium tuberculosis. It can affect any organ, and has a higher incidence with the increase of HIV infection, or in countries with high pulmonary tuberculosis. Diagnosis is difficult, mostly because of non-specific symptoms and a low rate of presentation for medical consult when symptoms do occur. Complete diagnosis is usually set by histological, immunohistochemical examinations, and also with Polymerase Chain Reaction (PCR) in selected cases. The authors present a case of concomitant tuberculosis of the nose, paranasal sinuses and subglottic larynx, without primary involvement of the lungs. The diagnosis was imposed by histological examination and immunostaining of probes obtained in surgery. The treatment was surgical debridement followed by specific antituberculosis medication.
authors.affiliation: Department of Anatomy, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; ibulescu@gmail.com.
authors.forename: Vlad Andrei
authors.initials: VA
authors.lastname: Budu
authors.forename: Ioan Alexandru
authors.initials: IA
authors.lastname: Bulescu
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schnaider
authors.forename: Cristiana Gabriela
authors.initials: CG
authors.lastname: Popp
authors.forename: Claudia Lucia
authors.initials: CL
authors.lastname: Toma
authors.forename: Carmen Aurelia
authors.initials: CA
authors.lastname: Mogoantă
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Mühlfay
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D003287:Contrast Media / Q000737:chemistry; D006644:Histiocytes / Q000166:cytology; D006801:Humans; D007150:Immunohistochemistry; D007830:Larynx / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008443:Maxillary Sinus / Q000382:microbiology / Q000473:pathology*; D009666:Nose / Q000382:microbiology / Q000473:pathology*; D016133:Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D003287:Contrast Media