title: Molecular diversity of spirooxindoles. Synthesis and biological activity.
abstract: Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work. The spirooxindoles in this review are separated into three structural classes, and then further categorized into the method type from which the spirocycle is generated.
authors.affiliation: State Scientific Institution, "Institute for Single Crystals" of National Academy of Sciences of Ukraine, Lenina Pr., 60, Kharkov, 61002, Ukraine. tetjanka1@yandex.ru.
authors.forename: Tetyana L
authors.initials: TL
authors.lastname: Pavlovska
authors.affiliation: National University of Pharmacy, Pushkinska Str., 53, Kharkov, 61002, Ukraine. ruslan.red.chem@gmail.com.
authors.forename: Ruslan Gr
authors.initials: RG
authors.lastname: Redkin
authors.affiliation: State Scientific Institution, "Institute for Single Crystals" of National Academy of Sciences of Ukraine, Lenina Pr., 60, Kharkov, 61002, Ukraine. lipson@ukr.net.|State Institution "V.Ya. Danilevsky Institute of Endocrine Pathology Problems", Academy of Medical Sciences of Ukraine, Artema Str., 10, Kharkov, 61002, Ukraine. lipson@ukr.net.
authors.forename: Victoria V
authors.initials: VV
authors.lastname: Lipson
authors.affiliation: Dmytro Atamanyuk Mutabilis, 102 Av. Gaston Roussel, Romainville, 93230, France. 4dmytro@gmail.com.
authors.forename: Dmytro V
authors.initials: DV
authors.lastname: Atamanuk
mesh_terms: D061565:Cycloaddition Reaction; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D007211:Indoles; D013141:Spiro Compounds
keywords: Cycloadditions; DOS; Diversity-oriented synthesis; Highly functionalised molecules; Isatin; Multicomponent reactions (MCRs); Oxindoles; Spiroheterocyclic systems