title: In children with Hashimoto's thyroiditis the evolution over time of thyroid status may differ according to the different presentation patterns.
abstract: OBJECTIVE
  to report the salient literature news concerning the relationships between thyroid function presenting patterns and subsequent biochemical evolution of Hashimoto's thyroiditis (HT) in pediatric age.
  
  
  METHODS
  the most recent reports from pediatric literature concerning biochemical thyroid function patterns at HT presentation and their spontaneous changes over time were analyzed and shortly commented.
  
  
  RESULTS
  from the analysis of pediatric literature on this theme, it emerges that HT in children may present with a very heterogeneous biochemical picture ranging from overt hypothyroidism to overt hyperthyroidism. The presenting biochemical pattern may also condition its subsequent evolution over time.
  
  
  CONCLUSIONS
  a) the most common biochemical pattern at HT diagnosis in children is euthyroidism, followed by overt hypothyroidism, subclinical hypothyroidism (SH) and hyperthyroidism; b) the association with HT negatively affects the evolution over time of SH; c) in the cases with either Turner syndrome or Down syndrome the evolution over time of SH is more severe than in those without these chromosomopathies.
authors.affiliation: Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy. zirillig@gmail.com.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Zirilli
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Velletri
authors.forename: Federica
authors.initials: F
authors.lastname: Porcaro
authors.forename: Gilberto
authors.initials: G
authors.lastname: Candela
authors.forename: Pina
authors.initials: P
authors.lastname: Maisano
authors.forename: Giuseppina
authors.initials: G
authors.lastname: La Monica
mesh_terms: D002648:Child; D018450:Disease Progression; D050031:Hashimoto Disease / Q000378:metabolism*; D006801:Humans; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D013963:Thyroid Hormones