title: The role of S100 proteins and their receptor RAGE in pancreatic cancer.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with low survival rates. Current therapeutic treatments have very poor response rates due to the high inherent chemoresistance of the pancreatic-cancer cells. Recent studies have suggested that the receptor for advanced glycation end products (RAGE) and its S100 protein ligands play important roles in the progression of PDAC. We will discuss the potential role of S100 proteins and their receptor, RAGE, in the development and progression of pancreatic cancer.
authors.affiliation: Department of Pharmaceutical Sciences, North Dakota State University, PO Box 6050, Department 2665, Fargo, ND 58108-6050, USA. Electronic address: Estelle.Leclerc@ndsu.edu.
authors.forename: Estelle
authors.initials: E
authors.lastname: Leclerc
authors.affiliation: Department of Pharmaceutical Sciences, North Dakota State University, PO Box 6050, Department 2665, Fargo, ND 58108-6050, USA.
authors.forename: Stefan W
authors.initials: SW
authors.lastname: Vetter
keywords: Pancreatic ductal adenocarcinoma; RAGE; S100 proteins