title: Drug-Induced Diabetes Mellitus: Evidence for Statins and Other Drugs Affecting Glucose Metabolism.
abstract: Abnormalities of glucose metabolism and glucose tolerance, either because of a reduction in tissue sensitivity to insulin (e.g., in liver, skeletal muscle, and adipose tissues) and/or a reduction in pancreatic insulin secretion, are associated with a number of unwanted health outcomes. Even small increases in circulating glucose levels (often described as dysglycemia or prediabetes) may confer an increased risk of cardiovascular (CV) disease and progression to overt type 2 diabetes. A number of drug therapies, many of them used long term in chronic disease management, have adverse effects on glucose metabolism, diabetes risk, and glycemic control among patients with preexisting diabetes. In this study, we review the evidence, underlying mechanisms, and the clinical significance of drug-related adverse effects on glucose metabolism.
authors.affiliation: Division of Medical Sciences & GEM, School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby, UK.
authors.forename: U
authors.initials: U
authors.lastname: Anyanwagu
authors.affiliation: Division of Medical Sciences & GEM, School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby, UK.
authors.forename: I
authors.initials: I
authors.lastname: Idris
authors.affiliation: Division of Medical Sciences & GEM, School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby, UK.
authors.forename: R
authors.initials: R
authors.lastname: Donnelly
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D019338:Polypharmacy; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors