title: Perampanel in the treatment of focal and idiopathic generalized epilepsies and of status epilepticus.
abstract: Perampanel is the latest approved antiepileptic drug in focal and generalized epilepsies and has a distinct and selective mode of action on AMPA-receptors. Several thousand patients have received perampanel within randomized placebo-controlled trials, open-label extension trials and post-marketing observational studies. Significant median partial-onset seizure reduction rates of 23% for 4 mg/day, 26-31% for 8 mg/day and 18-35% for 12 mg/day were reported. Likewise 50 percent responder rates were 29% for 4 mg/day, 33-38% for 8 mg/day and 34-36% for 12 mg/day. Primary generalized tonic-clonic seizures were reduced by 76.5% (8 mg) vs 38.4% (placebo) in a recent controlled trial. Overall, perampanel is well tolerated and the main adverse events are dizziness, somnolence and fatigue. There are also anecdotal reports on use in progressive myoclonic epilepsies and status epilepticus. Perampanel will likely remain an important, possibly broad-spectrum AED with a significant market share, especially in patients with drug-refractory epilepsies.
authors.affiliation: a 1 Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe-University , Frankfurt am Main, Germany.|b 2 Epilepsy Center Hessen and Department of Neurology, Philipps-University , Marburg, Germany.
authors.forename: Adam
authors.initials: A
authors.lastname: Strzelczyk
authors.affiliation: a 1 Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe-University , Frankfurt am Main, Germany.
authors.forename: Laurent M
authors.initials: LM
authors.lastname: Willems
authors.affiliation: a 1 Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe-University , Frankfurt am Main, Germany.
authors.forename: Sophia
authors.initials: S
authors.lastname: Willig
authors.affiliation: a 1 Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe-University , Frankfurt am Main, Germany.|b 2 Epilepsy Center Hessen and Department of Neurology, Philipps-University , Marburg, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Rosenow
authors.affiliation: a 1 Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe-University , Frankfurt am Main, Germany.|b 2 Epilepsy Center Hessen and Department of Neurology, Philipps-University , Marburg, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bauer
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D009570:Nitriles; D011728:Pyridones / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*; D013226:Status Epilepticus / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D009570:Nitriles; D011728:Pyridones; D018091:Receptors, AMPA; C551441:perampanel
keywords: epilepsy; myoclonus; perampanel; seizure; status epilepticus