title: A "turn-on" fluorescent chemosensor for aluminum ion and cell imaging application.
abstract: A simple and efficient fluorescent chemosensor for Al(3+) is reported in the paper. The chemosensor is obtained by dehydration reaction of 2-hydroxy-1-naphthaldehyde and 2-aminophenol. The chemosensor has high selectivity and sensitivity for Al(3+) and displays fluorescence "off-on" switch signal. The detection limit of the chemosensor for Al(3+) can reach 1.0×10(-7) M in DMSO/H2O (1:9, v/v) solution. The mass spectra and Job's plot analysis confirm the 1:1 stoichiometry between chemosensor and Al(3+). Potential utilization of the probe as an intracellular sensor of Al(3+) in human cancer (HiSa) cells is also examined by confocal fluorescence microscopy.
authors.affiliation: School of Chinese Materia Medica, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, PR China.
authors.forename: Ailing
authors.initials: A
authors.lastname: Guo
authors.affiliation: Department of Chemistry, Taiyuan Normal University, Taiyuan 030031, PR China. Electronic address: ruitaozhu@126.com.
authors.forename: Ruitao
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Department of Chemistry, Taiyuan Normal University, Taiyuan 030031, PR China.
authors.forename: Yuehong
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Chemistry, Taiyuan Normal University, Taiyuan 030031, PR China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Dong
authors.affiliation: School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, PR China. Electronic address: lhfeng@sxu.edu.cn.
authors.forename: Liheng
authors.initials: L
authors.lastname: Feng
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007477:Ions; D057054:Molecular Imaging / Q000379:methods*; D009281:Naphthalenes / Q000737:chemistry; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D009281:Naphthalenes; D012996:Solutions; D000535:Aluminum
keywords: Aluminum ion; Cell imaging; Chemosensor; Fluorescence; Naphthalene