title: Translating the effects of mTOR on secretory senescence.
abstract: Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization.
authors.affiliation: University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Tomimatsu
authors.affiliation: University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
authors.forename: Masashi
authors.initials: M
authors.lastname: Narita
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic; D014176:Protein Biosynthesis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D020871:RNA Stability; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D020123:Sirolimus / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D014158:Transcription, Genetic; D000099190:MAP-Kinase-Activated Kinase 2
chemical_list: D053582:Interleukin-1alpha; D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D020123:Sirolimus; D058570:TOR Serine-Threonine Kinases; D000099190:MAP-Kinase-Activated Kinase 2