title: Demodicosis in Renal Transplant Recipients.
abstract: Solid organ transplant recipients have an increased incidence of skin infections resulting from immunosuppression. Common pathogens include herpes simplex virus, varicella zoster virus, Gram-positive bacteria and dermatophytes; however, the contribution of multicellular parasitic organisms to dermatologic disease in this population remains less studied. Demodex folliculorum and brevis are commensal mites that reside on human skin. Proliferation of Demodex mites, or demodicosis, is associated with rosacea and rosacea-like disorders, particularly in immunocompromised populations, although their ability to cause disease is still the subject of debate. We present a case series of four renal transplant recipients with the singular chief complaint of acne rosacea who we diagnosed with demodicosis. Although one of the four patients showed complete resolution following initial antiparasitic therapy, the other three required subsequent antibacterial treatment to fully resolve their lesions. We suggest that demodicosis may be more prevalent than once thought in solid organ transplant recipients and showed that Demodex-associated acne rosacea can be effectively treated in this population.
authors.affiliation: Yale Transplant Dermatology Clinic, New Haven, CT.
authors.forename: R J
authors.initials: RJ
authors.lastname: Chovatiya
authors.affiliation: Yale Transplant Dermatology Clinic, New Haven, CT.
authors.forename: O R
authors.initials: OR
authors.lastname: Colegio
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000175:diagnosis / Q000209:etiology*; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D008924:Mite Infestations / Q000175:diagnosis / Q000209:etiology*; D008925:Mites / Q000472:pathogenicity*; D011183:Postoperative Complications; D011379:Prognosis; D012307:Risk Factors; D012393:Rosacea / Q000175:diagnosis / Q000209:etiology*; D066027:Transplant Recipients
chemical_list: D007166:Immunosuppressive Agents