title: Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects.
abstract: OBJECTIVE
  Optical coherence tomography angiography (OCTA) is a novel, non-invasive OCT technique capable of imaging the retinal vasculature. This study aims to evaluate the retinal microvasculature in diabetic human subjects with OCTA and assess potential clinical applications.
  
  
  METHODS
  Cross-sectional study of 33 subjects with diabetic retinopathy. OCTA was performed on 3 mm × 3 mm sections using a swept-source OCTA prototype and a phase- and intensity-based contrasting algorithm. OCT angiograms were studied with corresponding clinical examination and fluorescein angiograms, when available, to assess accuracy and clinical utility.
  
  
  RESULTS
  OCTA was able to demonstrate most clinically relevant vascular changes in subjects with diabetic retinopathy, including microaneurysms, impaired vascular perfusion, some forms of intraretinal fluid, vascular loops, intraretinal microvascular abnormalities, neovascularization, and cotton-wool spots that were largely consistent with fluorescein angiography.
  
  
  CONCLUSIONS
  OCTA generates high-resolution angiograms that illustrate many of the clinically relevant findings in diabetic retinopathy and offers a novel complement or alternative to fluorescein angiography. Although currently an investigational technique, OCTA in combination with standard OCT imaging is at least as good as fluorescein angiography in the evaluation of the macular complications of diabetic retinopathy.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Matsunaga
authors.forename: Jack J
authors.initials: JJ
authors.lastname: Yi
authors.forename: Lisa Olmos
authors.initials: LO
authors.lastname: De Koo
authors.forename: Hossein
authors.initials: H
authors.lastname: Ameri
authors.forename: Carmen A
authors.initials: CA
authors.lastname: Puliafito
authors.forename: Amir H
authors.initials: AH
authors.lastname: Kashani
mesh_terms: D000368:Aged; D000783:Aneurysm / Q000175:diagnosis / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000175:diagnosis* / Q000503:physiopathology; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D015861:Retinal Neovascularization / Q000175:diagnosis / Q000503:physiopathology; D012171:Retinal Vessels / Q000473:pathology*; D058471:Subretinal Fluid; D041623:Tomography, Optical Coherence