title: Prevalence and risk factors of coronary artery disease in patients with chronic viral hepatitis.
abstract: OBJECTIVE
  Patients with chronic viral hepatitis usually present metabolic abnormalities and hemodynamic changes, which are known factors associated with the development of coronary artery disease (CAD). This study aims to determine the risk factors of incident CAD in these patients.
  
  
  METHODS
  We identified 193 patients who subsequently developed CAD amongst 37,840 cases diagnosed as chronic viral hepatitis from January 2007 through December 2013.
  
  
  RESULTS
  In these patients, 141 had hepatitis B virus infections and 52 had hepatitis C virus infections. There was a male preponderance (65.9%). The median age at the diagnosis of hepatitis was 51 years. In the univariate analysis, patients aged ≥ 51 years had shorter median periods from the diagnosis of hepatitis to the onset of CAD than patients aged < 51 years (50 versus 96 months, p < 0.001), and patients with hypertension had shorter median durations compared to those without hypertension (48 versus 96 months, p < 0.001). Statistical significance also existed between patients with different etiologies (p = 0.004). In the multivariate analysis by Cox regression, age at the diagnosis of hepatitis (p < 0.001; hazard ratio (HR), 1.041; 95% CI, 1.027-1.056) and hypertension (with versus without, p < 0.001; HR, 1.925; 95% CI, 1.419-2.611) were revealed.
  
  
  CONCLUSIONS
  Age at diagnosis of hepatitis and hypertension appeared to be independent risk factors of incident CAD in these patients. This topic deserves further studies.
authors.affiliation: a 1 Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University , Beijing 100029, China.
authors.forename: Chunya
authors.initials: C
authors.lastname: Wang
authors.affiliation: b 2 Clinical Trial Center, Beijing 302 Hospital (302 Hospital of PLA) , Beijing 100039, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Zhao
authors.affiliation: a 1 Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University , Beijing 100029, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Luo
authors.affiliation: c 3 Department of Statistics, Academy of Military Medical Science , Beijing 100850, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Liu
authors.affiliation: d 4 Medical Record Center, Beijing 302 Hospital (302 Hospital of PLA) , Beijing 100039, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: e 5 Department of Special Medical Service, Beijing Anzhen Hospital, Capital Medical University , Beijing 100029, China.
authors.forename: Quanming
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000367:Age Factors; D017668:Age of Onset; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000453:epidemiology*; D005260:Female; D019694:Hepatitis B, Chronic / Q000453:epidemiology*; D019698:Hepatitis C, Chronic / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016016:Proportional Hazards Models; D012307:Risk Factors; D012737:Sex Factors
keywords: Coronary artery disease; chronic viral hepatitis; prevalence; risk factor