title: Cognitive Performance at Late Adolescence and the Risk for Impaired Fasting Glucose Among Young Adults.
abstract: BACKGROUND
  Although dysglycemia is a risk factor for cognitive decline, it is unknown whether cognitive performance among young and apparently healthy adults affect the risk for impaired fasting glucose (IFG).
  
  
  OBJECTIVE
  This study aimed to characterize the relationship between cognitive function and the risk for IFG among young adults.
  
  
  METHODS
  This was a retrospective cohort study utilizing data collected at pre-military recruitment assessments with information collected at the screening center of Israeli Army Medical Corps.
  
  
  METHODS
  Normoglycemic adults (n = 17 348) (free of IFG and diabetes; mean age 31.0 ± 5.6 y; 87% men) of the Metabolic Lifestyle and Nutrition Assessment in Young Adults (MELANY) cohort with data regarding their General Intelligence Score (GIS), a comprehensive measure of cognitive function, at age 17 y.
  
  
  METHODS
  Fasting plasma glucose was assessed every 3-5 y at scheduled visits. Cox proportional hazards models were applied.
  
  
  METHODS
  The main outcome of the study was incident IFG (≥ 100 mg/dL and <126 mg/dL) at scheduled visits.
  
  
  RESULTS
  During a median followup of 6.6 y, 1478 cases of IFG were recorded (1402 men). After adjustment for age and sex, participants in the lowest GIS category had a 1.9-fold greater risk for incident IFG compared with those in the highest GIS category. In multivariable analysis adjusted for age, sex, body mass index, fasting plasma glucose, family history of diabetes, country of origin, socioeconomic status, education, physical activity, smoking status, alcohol consumption, breakfast consumption, triglyceride level, white blood cell count, the risk for IFG was nearly doubled in the lowest GIS category compared with the highest GIS category (hazard ratio, 1.8; 95% confidence interval, 1.4-2.3; P < .001). These results persisted when GIS was treated as a continuous variable and when the model was adjusted also for body mass index at the end of followup.
  
  
  CONCLUSIONS
  This study demonstrates that lower cognitive function at late adolescence is independently associated with an elevated risk IFG in both men and women.
authors.affiliation: The Sackler School of Medicine (T.C.-Y., A.A., E.D., A.K., G.T.), Tel Aviv University, Tel Aviv, Israel; Department of Endocrinology (T.C.-Y., M.K.-M., A.K.), Sheba Medical Center, Tel Hashomer, Israel; Gertner Institute for Epidemiology (T.C.-Y.), Tel Hashomer, Israel; The Israel Defense Forces Medical Corps (E.F., E.D., D.T., G.T.), Israel; Division of Endocrinology & Metabolism, and Population Healthy Research Institute (H.C.G.), McMaster University & Hamilton Health Sciences, Hamilton, Canada; The Israel Ministry of Health (A.A.), Jerusalem, Israel; Department of Medicine B (G.T.), Sheba Medical Center, Tel Hashomer 52621, Israel; and The Dr Pinchas Bornstein Talpiot Medical Leadership Program (G.T.), Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Tali
authors.initials: T
authors.lastname: Cukierman-Yaffe
authors.affiliation: The Sackler School of Medicine (T.C.-Y., A.A., E.D., A.K., G.T.), Tel Aviv University, Tel Aviv, Israel; Department of Endocrinology (T.C.-Y., M.K.-M., A.K.), Sheba Medical Center, Tel Hashomer, Israel; Gertner Institute for Epidemiology (T.C.-Y.), Tel Hashomer, Israel; The Israel Defense Forces Medical Corps (E.F., E.D., D.T., G.T.), Israel; Division of Endocrinology & Metabolism, and Population Healthy Research Institute (H.C.G.), McMaster University & Hamilton Health Sciences, Hamilton, Canada; The Israel Ministry of Health (A.A.), Jerusalem, Israel; Department of Medicine B (G.T.), Sheba Medical Center, Tel Hashomer 52621, Israel; and The Dr Pinchas Bornstein Talpiot Medical Leadership Program (G.T.), Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Kasher-Meron
authors.affiliation: The Sackler School of Medicine (T.C.-Y., A.A., E.D., A.K., G.T.), Tel Aviv University, Tel Aviv, Israel; Department of Endocrinology (T.C.-Y., M.K.-M., A.K.), Sheba Medical Center, Tel Hashomer, Israel; Gertner Institute for Epidemiology (T.C.-Y.), Tel Hashomer, Israel; The Israel Defense Forces Medical Corps (E.F., E.D., D.T., G.T.), Israel; Division of Endocrinology & Metabolism, and Population Healthy Research Institute (H.C.G.), McMaster University & Hamilton Health Sciences, Hamilton, Canada; The Israel Ministry of Health (A.A.), Jerusalem, Israel; Department of Medicine B (G.T.), Sheba Medical Center, Tel Hashomer 52621, Israel; and The Dr Pinchas Bornstein Talpiot Medical Leadership Program (G.T.), Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Eyal
authors.initials: E
authors.lastname: Fruchter
authors.affiliation: The Sackler School of Medicine (T.C.-Y., A.A., E.D., A.K., G.T.), Tel Aviv University, Tel Aviv, Israel; Department of Endocrinology (T.C.-Y., M.K.-M., A.K.), Sheba Medical Center, Tel Hashomer, Israel; Gertner Institute for Epidemiology (T.C.-Y.), Tel Hashomer, Israel; The Israel Defense Forces Medical Corps (E.F., E.D., D.T., G.T.), Israel; Division of Endocrinology & Metabolism, and Population Healthy Research Institute (H.C.G.), McMaster University & Hamilton Health Sciences, Hamilton, Canada; The Israel Ministry of Health (A.A.), Jerusalem, Israel; Department of Medicine B (G.T.), Sheba Medical Center, Tel Hashomer 52621, Israel; and The Dr Pinchas Bornstein Talpiot Medical Leadership Program (G.T.), Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Hertzel C
authors.initials: HC
authors.lastname: Gerstein
authors.affiliation: The Sackler School of Medicine (T.C.-Y., A.A., E.D., A.K., G.T.), Tel Aviv University, Tel Aviv, Israel; Department of Endocrinology (T.C.-Y., M.K.-M., A.K.), Sheba Medical Center, Tel Hashomer, Israel; Gertner Institute for Epidemiology (T.C.-Y.), Tel Hashomer, Israel; The Israel Defense Forces Medical Corps (E.F., E.D., D.T., G.T.), Israel; Division of Endocrinology & Metabolism, and Population Healthy Research Institute (H.C.G.), McMaster University & Hamilton Health Sciences, Hamilton, Canada; The Israel Ministry of Health (A.A.), Jerusalem, Israel; Department of Medicine B (G.T.), Sheba Medical Center, Tel Hashomer 52621, Israel; and The Dr Pinchas Bornstein Talpiot Medical Leadership Program (G.T.), Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Arnon
authors.initials: A
authors.lastname: Afek
authors.affiliation: The Sackler School of Medicine (T.C.-Y., A.A., E.D., A.K., G.T.), Tel Aviv University, Tel Aviv, Israel; Department of Endocrinology (T.C.-Y., M.K.-M., A.K.), Sheba Medical Center, Tel Hashomer, Israel; Gertner Institute for Epidemiology (T.C.-Y.), Tel Hashomer, Israel; The Israel Defense Forces Medical Corps (E.F., E.D., D.T., G.T.), Israel; Division of Endocrinology & Metabolism, and Population Healthy Research Institute (H.C.G.), McMaster University & Hamilton Health Sciences, Hamilton, Canada; The Israel Ministry of Health (A.A.), Jerusalem, Israel; Department of Medicine B (G.T.), Sheba Medical Center, Tel Hashomer 52621, Israel; and The Dr Pinchas Bornstein Talpiot Medical Leadership Program (G.T.), Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Estela
authors.initials: E
authors.lastname: Derazne
authors.affiliation: The Sackler School of Medicine (T.C.-Y., A.A., E.D., A.K., G.T.), Tel Aviv University, Tel Aviv, Israel; Department of Endocrinology (T.C.-Y., M.K.-M., A.K.), Sheba Medical Center, Tel Hashomer, Israel; Gertner Institute for Epidemiology (T.C.-Y.), Tel Hashomer, Israel; The Israel Defense Forces Medical Corps (E.F., E.D., D.T., G.T.), Israel; Division of Endocrinology & Metabolism, and Population Healthy Research Institute (H.C.G.), McMaster University & Hamilton Health Sciences, Hamilton, Canada; The Israel Ministry of Health (A.A.), Jerusalem, Israel; Department of Medicine B (G.T.), Sheba Medical Center, Tel Hashomer 52621, Israel; and The Dr Pinchas Bornstein Talpiot Medical Leadership Program (G.T.), Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Dorit
authors.initials: D
authors.lastname: Tzur
authors.affiliation: The Sackler School of Medicine (T.C.-Y., A.A., E.D., A.K., G.T.), Tel Aviv University, Tel Aviv, Israel; Department of Endocrinology (T.C.-Y., M.K.-M., A.K.), Sheba Medical Center, Tel Hashomer, Israel; Gertner Institute for Epidemiology (T.C.-Y.), Tel Hashomer, Israel; The Israel Defense Forces Medical Corps (E.F., E.D., D.T., G.T.), Israel; Division of Endocrinology & Metabolism, and Population Healthy Research Institute (H.C.G.), McMaster University & Hamilton Health Sciences, Hamilton, Canada; The Israel Ministry of Health (A.A.), Jerusalem, Israel; Department of Medicine B (G.T.), Sheba Medical Center, Tel Hashomer 52621, Israel; and The Dr Pinchas Bornstein Talpiot Medical Leadership Program (G.T.), Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Avraham
authors.initials: A
authors.lastname: Karasik
authors.affiliation: The Sackler School of Medicine (T.C.-Y., A.A., E.D., A.K., G.T.), Tel Aviv University, Tel Aviv, Israel; Department of Endocrinology (T.C.-Y., M.K.-M., A.K.), Sheba Medical Center, Tel Hashomer, Israel; Gertner Institute for Epidemiology (T.C.-Y.), Tel Hashomer, Israel; The Israel Defense Forces Medical Corps (E.F., E.D., D.T., G.T.), Israel; Division of Endocrinology & Metabolism, and Population Healthy Research Institute (H.C.G.), McMaster University & Hamilton Health Sciences, Hamilton, Canada; The Israel Ministry of Health (A.A.), Jerusalem, Israel; Department of Medicine B (G.T.), Sheba Medical Center, Tel Hashomer 52621, Israel; and The Dr Pinchas Bornstein Talpiot Medical Leadership Program (G.T.), Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Gilad
authors.initials: G
authors.lastname: Twig
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003071:Cognition / Q000502:physiology*; D015331:Cohort Studies; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007361:Intelligence Tests; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D009765:Obesity / Q000453:epidemiology; D011236:Prediabetic State / Q000150:complications; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008075:Lipoproteins, HDL; D014280:Triglycerides