title: Active and passive case detection strategies for the control of leishmaniasis in Bangladesh.
abstract: METHODS
  Two subdistricts in Bangladesh, Fulbaria and Trishal, which are hyperendemic for leishmaniasis.
  
  
  OBJECTIVE
  To determine 1) the numbers of patients diagnosed with visceral leishmaniasis (VL) and post-kala azar dermal leishmaniasis (PKDL) using an active case detection (ACD) strategy in Fulbaria and a passive case detection (PCD) strategy in Trishal, and 2) the time taken from symptoms to diagnosis in the ACD subdistrict.
  
  
  METHODS
  A cross-sectional descriptive study of patients diagnosed from May 2010 to December 2011. The ACD strategy involved community education and outreach workers targeting households of index patients using symptom-based screening and rK-39 tests for suspected cases.
  
  
  RESULTS
  In the ACD subdistrict (Fulbaria) and PCD sub-district (Trishal), respectively 1088 and 756 residents were diagnosed with VL and 1145 and 37 with PKDL. In the ACD subdistrict, the median time to diagnosis for patients directly referred by outreach workers or self-referred was similar, at 60 days for VL and respectively 345 and 360 days for PKDL.
  
  
  CONCLUSIONS
  An ACD strategy at the subdistrict level resulted in an increased yield of VL and a much higher yield of PKDL. As PKDL acts as a reservoir for infection, a strategy of ACD and treatment can contribute to the regional elimination of leishmaniasis in the Indian sub-continent.
authors.affiliation: Médecins Sans Frontières (MSF), Amsterdam, The Netherlands.
authors.forename: A K
authors.initials: AK
authors.lastname: Das
authors.affiliation: International Union Against Tuberculosis and Lung Disease (The Union), Paris, France ; Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Harries
authors.affiliation: Center for International Health, University of Bergen, Norway.
authors.forename: S G
authors.initials: SG
authors.lastname: Hinderaker
authors.affiliation: Operational Research Unit, MSF, Luxembourg.
authors.forename: R
authors.initials: R
authors.lastname: Zachariah
authors.affiliation: Communicable Disease Control, Directorate General of Health Services, Ministry of Health and Family Welfare, Bangladesh.
authors.forename: B
authors.initials: B
authors.lastname: Ahmed
authors.affiliation: Communicable Disease Control, Directorate General of Health Services, Ministry of Health and Family Welfare, Bangladesh.
authors.forename: G N
authors.initials: GN
authors.lastname: Shah
authors.affiliation: Operational Research Unit, MSF, Luxembourg.
authors.forename: M A
authors.initials: MA
authors.lastname: Khogali
authors.affiliation: Médecins Sans Frontières (MSF), Amsterdam, The Netherlands.
authors.forename: G I
authors.initials: GI
authors.lastname: Das
authors.affiliation: Médecins Sans Frontières (MSF), Amsterdam, The Netherlands.
authors.forename: E M
authors.initials: EM
authors.lastname: Ahmed
authors.affiliation: Médecins Sans Frontières (MSF), Amsterdam, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Ritmeijer
keywords: Bangladesh; case detection strategies; post-kala azar dermal leishmaniasis; visceral leishmaniasis