title: H2S: A Novel Gasotransmitter that Signals by Sulfhydration.
abstract: Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S.
authors.affiliation: The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: bpaul8@jhmi.edu.
authors.forename: Bindu D
authors.initials: BD
authors.lastname: Paul
authors.affiliation: The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: ssnyder@jhmi.edu.
authors.forename: Solomon H
authors.initials: SH
authors.lastname: Snyder
mesh_terms: D064426:Gasotransmitters / Q000378:metabolism*; D006862:Hydrogen Sulfide / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D064426:Gasotransmitters; D006862:Hydrogen Sulfide
keywords: cysteine; gasotransmitter; hydrogen sulfide; sulfhydration