title: The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease.
abstract: BACKGROUND
  Huntington's disease (HD) is a dominantly inherited disease caused by a CAG expansion mutation in HTT. The age at onset of clinical symptoms is determined primarily by the length of this CAG expansion but is also influenced by other genetic and/or environmental factors.
  
  
  OBJECTIVE
  Recently, through genome-wide association studies (GWAS) aimed at discovering genetic modifiers, we identified loci associated with age at onset of motor signs that are significant at the genome-wide level. However, many additional HD modifiers may exist but may not have achieved statistical significance due to limited power.
  
  
  METHODS
  In order to disseminate broadly the entire GWAS results and make them available to complement alternative approaches, we have developed the internet website "GeM MOA" where genetic association results can be searched by gene name, SNP ID, or genomic coordinates of a region of interest.
  
  
  RESULTS
  Users of the Genetic Modifiers of Motor Onset Age (GeM MOA) site can therefore examine support for association between any gene region and age at onset of HD motor signs. GeM MOA's interactive interface also allows users to navigate the surrounding region and to obtain association p-values for individual SNPs.
  
  
  CONCLUSIONS
  Our website conveys a comprehensive view of the genetic landscape of modifiers of HD from the existing GWAS, and will provide the means to evaluate the potential influence of genes of interest on the onset of HD. GeM MOA is freely available at https://www.hdinhd.org/.
authors.affiliation: Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Correia
authors.affiliation: Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.
authors.forename: Denise
authors.initials: D
authors.lastname: Harold
authors.affiliation: Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.|Department of Neurology, Harvard Medical School, Boston, MA, USA.
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Holmans
authors.affiliation: Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.
authors.forename: Lesley
authors.initials: L
authors.lastname: Jones
authors.affiliation: Department of Neurology, University of Ulm, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Orth
authors.affiliation: Department of Neurology and Genome Science Institute, Boston University School of Medicine, Boston, MA, USA.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Myers
authors.affiliation: CHDI Foundation, Princeton, NJ, USA.
authors.forename: Seung
authors.initials: S
authors.lastname: Kwak
authors.affiliation: Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.|Department of Neurology, Harvard Medical School, Boston, MA, USA.
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Wheeler
authors.affiliation: Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.|Department of Neurology, Harvard Medical School, Boston, MA, USA.|Medical and Population Genetics Program, The Broad Institute of M.I.T. and Harvard, Cambridge, MA, USA.
authors.forename: Marcy E
authors.initials: ME
authors.lastname: MacDonald
authors.affiliation: Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.|Medical and Population Genetics Program, The Broad Institute of M.I.T. and Harvard, Cambridge, MA, USA.|Department of Genetics, Harvard Medical School, Boston, MA, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Gusella
authors.affiliation: Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.|Department of Neurology, Harvard Medical School, Boston, MA, USA.|Medical and Population Genetics Program, The Broad Institute of M.I.T. and Harvard, Cambridge, MA, USA.
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
mesh_terms: D017668:Age of Onset; D060045:Genes, Modifier; D055106:Genome-Wide Association Study; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D020407:Internet; D020641:Polymorphism, Single Nucleotide