title: A multicenter study of the early detection of synaptic dysfunction in Mild Cognitive Impairment using Magnetoencephalography-derived functional connectivity.
abstract: Synaptic disruption is an early pathological sign of the neurodegeneration of Dementia of the Alzheimer's type (DAT). The changes in network synchronization are evident in patients with Mild Cognitive Impairment (MCI) at the group level, but there are very few Magnetoencephalography (MEG) studies regarding discrimination at the individual level. In an international multicenter study, we used MEG and functional connectivity metrics to discriminate MCI from normal aging at the individual person level. A labeled sample of features (links) that distinguished MCI patients from controls in a training dataset was used to classify MCI subjects in two testing datasets from four other MEG centers. We identified a pattern of neuronal hypersynchronization in MCI, in which the features that best discriminated MCI were fronto-parietal and interhemispheric links. The hypersynchronization pattern found in the MCI patients was stable across the five different centers, and may be considered an early sign of synaptic disruption and a possible preclinical biomarker for MCI/DAT.
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Complutense University of Madrid and Technical University of Madrid, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Maestú
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Complutense University of Madrid and Technical University of Madrid, Madrid, Spain.
authors.forename: Jose-Maria
authors.initials: JM
authors.lastname: Peña
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Complutense University of Madrid and Technical University of Madrid, Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Garcés
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Complutense University of Madrid and Technical University of Madrid, Madrid, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: González
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Complutense University of Madrid and Technical University of Madrid, Madrid, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bajo
authors.affiliation: Department of Neurology, University of Pittsburgh, Pittsburgh, USA.
authors.forename: Anto
authors.initials: A
authors.lastname: Bagic
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Complutense University of Madrid and Technical University of Madrid, Madrid, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Cuesta
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center, Houston, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Funke
authors.affiliation: BioMag Laboratory, HUS Medical Imaging Center, Helsinki University Central Hospital, Hensinki, Finland.
authors.forename: Jyrki P
authors.initials: JP
authors.lastname: Mäkelä
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Complutense University of Madrid and Technical University of Madrid, Madrid, Spain.
authors.forename: Ernestina
authors.initials: E
authors.lastname: Menasalvas
authors.affiliation: Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Obu, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Nakamura
authors.affiliation: Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Aalto, Espoo, Finland ; Elekta Oy, Helsinki, Finland.
authors.forename: Lauri
authors.initials: L
authors.lastname: Parkkonen
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Complutense University of Madrid and Technical University of Madrid, Madrid, Spain.
authors.forename: Maria E
authors.initials: ME
authors.lastname: López
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Complutense University of Madrid and Technical University of Madrid, Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Del Pozo
authors.affiliation: Human Genome Research Institute, National Institutes of Health, Bethesda, USA.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Sudre
authors.affiliation: Department of Neurology, University of Utah, Salt Lake City, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Zamrini
authors.affiliation: Department of Neurology, University of Helsinki, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Pekkonen
authors.affiliation: Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
authors.forename: Richard N
authors.initials: RN
authors.lastname: Henson
authors.affiliation: Department of Neurology, University of Pittsburgh, Pittsburgh, USA ; Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA ; Department of Psychology, University of Pittsburgh, Pittsburgh, USA.
authors.forename: James T
authors.initials: JT
authors.lastname: Becker
mesh_terms: D000368:Aged; D001921:Brain / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000503:physiopathology*; D003344:Cortical Synchronization; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D013569:Synapses / Q000502:physiology*
keywords: Data mining; Functional connectivity; Machine learning; Magnetoencephalography; Mild Cognitive Impairment; Multicenter study; Synaptic dysfunction