title: Intelligence May Moderate the Cognitive Profile of Patients with ASD.
abstract: BACKGROUND
  The intelligence of individuals with Autism Spectrum Disorder (ASD) varies considerably. The pattern of cognitive deficits associated with ASD may differ depending on intelligence. We aimed to study the absolute and relative severity of cognitive deficits in participants with ASD in relation to IQ.
  
  
  METHODS
  A total of 274 children (M age = 12.1, 68.6% boys) participated: 30 ASD and 22 controls in the below average Intelligence Quotient (IQ) group (IQ<85), 57 ASD and 54 controls in the average IQ group (85<IQ<115) and 41 ASD and 70 controls in the above average IQ group (IQ>115). Matching for age, sex, Full Scale IQ (FSIQ), Verbal IQ (VIQ), Performance IQ (PIQ) and VIQ-PIQ difference was performed. Speed and accuracy of social cognition, executive functioning, visual pattern recognition and basic processing speed were examined per domain and as a composite score.
  
  
  RESULTS
  The composite score revealed a trend significant IQ by ASD interaction (significant when excluding the average IQ group). In absolute terms, participants with below average IQs performed poorest (regardless of diagnosis). However, in relative terms, above average intelligent participants with ASD showed the most substantial cognitive problems (particularly for social cognition, visual pattern recognition and verbal working memory) since this group differed significantly from the IQ-matched control group (p < .001), whereas this was not the case for below-average intelligence participants with ASD (p = .57).
  
  
  CONCLUSIONS
  In relative terms, cognitive deficits appear somewhat more severe in individuals with ASD and above average IQs compared to the below average IQ patients with ASD. Even though high IQ ASD individuals enjoy a certain protection from their higher IQ, they clearly demonstrate cognitive impairments that may be targeted in clinical assessment and treatment. Conversely, even though in absolute terms ASD patients with below average IQs were clearly more impaired than ASD patients with average to above average IQs, the differences in cognitive functioning between participants with and without ASD on the lower end of the IQ spectrum were less pronounced. Clinically this may imply that cognitive assessment and training of cognitive skills in below average intelligent children with ASD may be a less fruitful endeavour. These findings tentatively suggest that intelligence may act as a moderator in the cognitive presentation of ASD, with qualitatively different cognitive processes affected in patients at the high and low end of the IQ spectrum.
authors.affiliation: Radboud University Nijmegen Medical Centre, Nijmegen, Donders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, The Netherlands; Karakter, Child and Adolescent Psychiatry University Centre Nijmegen, Nijmegen, the Netherlands.
authors.forename: Nanda
authors.initials: N
authors.lastname: Rommelse
authors.affiliation: Radboud University Nijmegen Medical Centre, Nijmegen, Donders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, The Netherlands.
authors.forename: Ilse
authors.initials: I
authors.lastname: Langerak
authors.affiliation: Radboud University Nijmegen Medical Centre, Nijmegen, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, Nijmegen, The Netherlands.
authors.forename: Jolanda
authors.initials: J
authors.lastname: van der Meer
authors.affiliation: Karakter, Child and Adolescent Psychiatry University Centre Nijmegen, Nijmegen, the Netherlands; Radboud University Nijmegen Medical Centre, Nijmegen, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, Nijmegen, The Netherlands.
authors.forename: Yvette
authors.initials: Y
authors.lastname: de Bruijn
authors.affiliation: Radboud University Nijmegen Medical Centre, Nijmegen, Donders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, The Netherlands; Karakter, Child and Adolescent Psychiatry University Centre Nijmegen, Nijmegen, the Netherlands.
authors.forename: Wouter
authors.initials: W
authors.lastname: Staal
authors.affiliation: Radboud University Nijmegen Medical Centre, Nijmegen, Donders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, The Netherlands; Karakter, Child and Adolescent Psychiatry University Centre Nijmegen, Nijmegen, the Netherlands.
authors.forename: Anoek
authors.initials: A
authors.lastname: Oerlemans
authors.affiliation: Karakter, Child and Adolescent Psychiatry University Centre Nijmegen, Nijmegen, the Netherlands; Radboud University Nijmegen Medical Centre, Nijmegen, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, Nijmegen, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Buitelaar
mesh_terms: D000067877:Autism Spectrum Disorder / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D007361:Intelligence Tests; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D014888:Wechsler Scales