title: Six-month quality-of-life and functional status of acute respiratory distress syndrome survivors compared to patients at risk: a population-based study.
abstract: BACKGROUND
  The long-term attributable burden related to acute respiratory distress syndrome (ARDS) is not fully investigated. The aim of this study is to evaluate the quality of life (QOL) and functional status at 6 months after hospitalization in patients at risk for ARDS who did and did not develop the syndrome.
  
  
  METHODS
  This is a population-based prospective cohort study of adult patients from Olmsted County, Minnesota, with or at risk for ARDS hospitalized from October 2008 to July 2011. The primary outcomes were changes in QOL and functional status, measured through 12-Item Short Form Survey (SF-12) and Barthel Index (BI) respectively, from baseline to 6 months, compared between survivors who did and did not develop ARDS.
  
  
  RESULTS
  Of 410 patients with or at risk for ARDS, 98 had baseline surveys collected and 67 responded to a 6-month survey (26 ARDS, 41 non-ARDS). Both ARDS and non-ARDS groups had lower physical component of SF-12 at baseline compared to general population (P < 0.001 for both). ARDS patients had poorer baseline functional status compared to non-ARDS (mean BI 80 ± 25 vs. 88 ± 22, P = 0.03). No significant differences were observed for the change between 6 months and baseline BI (delta 2.3 for ARDS vs. 2.0 for non-ARDS, P = 0.5), or mental (delta 2.7 vs. 2.4, P = 0.9) or physical (delta -3 vs. -3.3, P = 0.9) component of SF-12 between survivors with and without ARDS.
  
  
  CONCLUSIONS
  In this population-based study, decreased QOL and functional status 6 months after hospitalization were largely explained by baseline condition, with similar recovery in survivors who did and did not develop ARDS.
authors.affiliation: Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC) Group, Mayo Clinic, Rochester, MN, USA. mibiehl@yahoo.com.br.|Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA. mibiehl@yahoo.com.br.|Sanford USD Medical Center, 1205 S. Grange Avenue, Suite 407, Sioux Falls, SD, USA. mibiehl@yahoo.com.br.
authors.forename: Michelle
authors.initials: M
authors.lastname: Biehl
authors.affiliation: Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC) Group, Mayo Clinic, Rochester, MN, USA. kashyap.rahul@mayo.edu.
authors.forename: Rahul
authors.initials: R
authors.lastname: Kashyap
authors.affiliation: Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC) Group, Mayo Clinic, Rochester, MN, USA. doola2002@gmail.com.|Wichita Falls Family Practice Residency Program (WFFRP), North Central Texas Medical Foundation, Wichita Falls, TX, USA. doola2002@gmail.com.
authors.forename: Adil H
authors.initials: AH
authors.lastname: Ahmed
authors.affiliation: Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC) Group, Mayo Clinic, Rochester, MN, USA. mreriani@yahoo.com.|Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA. mreriani@yahoo.com.
authors.forename: Martin K
authors.initials: MK
authors.lastname: Reriani
authors.affiliation: Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC) Group, Mayo Clinic, Rochester, MN, USA. uofoma@geisinger.edu.|Department of Critical Care Medicine, Geisinger Medical Center, Danville, PA, USA. uofoma@geisinger.edu.
authors.forename: Uchenna R
authors.initials: UR
authors.lastname: Ofoma
authors.affiliation: Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC) Group, Mayo Clinic, Rochester, MN, USA. wilson.gregory@mayo.edu.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Wilson
authors.affiliation: Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC) Group, Mayo Clinic, Rochester, MN, USA. li.guangxi@mayo.edu.|Department of Medicine, Guang An Men Hospital, China Academy of Chinese Medical Science, Beijing, China. li.guangxi@mayo.edu.
authors.forename: Guangxi
authors.initials: G
authors.lastname: Li
authors.affiliation: Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC) Group, Mayo Clinic, Rochester, MN, USA. mikedabike62@gmail.com.|Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA. mikedabike62@gmail.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Malinchoc
authors.affiliation: Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA. jsloan@mayo.edu.
authors.forename: Jeff A
authors.initials: JA
authors.lastname: Sloan
authors.affiliation: Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC) Group, Mayo Clinic, Rochester, MN, USA. gajic.ognjen@mayo.edu.|Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA. gajic.ognjen@mayo.edu.
authors.forename: Ognjen
authors.initials: O
authors.lastname: Gajic
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012128:Respiratory Distress Syndrome / Q000150:complications*; D012307:Risk Factors; D017741:Survivors / Q000706:statistics & numerical data*