title: Effects of Multistrain Probiotic Supplementation on Glycemic and Inflammatory Indices in Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized Clinical Trial.
abstract: Nonalcoholic fatty liver disease (NAFLD) is a condition defined by exceeding triglycerides accumulation in the liver. The condition can develop into fibrosis, cirrhosis, and hepatocellular carcinoma. Considering the ever-increasing prevalence of NAFLD, the aim of the present study was to investigate the effects of probiotic supplementation on glycemic and inflammatory indices in patients with NAFLD.
  
  
  
  This randomized clinical trial was conducted on 42 patients with NAFLD who had been referred to a gastroenterology clinic. Subjects in the intervention and control groups consumed 2 capsules/day probiotic or placebo, respectively, for 8 weeks. Fasting blood sugar (FBS), insulin, insulin resistance, tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) were measured at baseline and at the end of the study.
  
  
  
  Means of FBS, insulin, insulin resistance, and IL-6 were significantly different between groups after intervention (p < 0.05), whereas TNF-α was not significantly modified (p > 0.05). In the probiotic group, insulin, insulin resistance, TNF-α, and IL-6 decreased significantly at the end of the study compared to the beginning of study.
  
  
  
  Considering the effects of probiotic supplementation on the reduction of glycemic and inflammatory indices in patients with NAFLD, consumption of probiotics is recommended as a complementary therapy in these patients.
authors.affiliation: a Health Research Center.
authors.forename: Abbaszadeh
authors.initials: A
authors.lastname: Sepideh
authors.affiliation: e Baqiyatallah University of Medical Sciences, Tehran, IRAN; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences , Tehran , IRAN.
authors.forename: Parastouei
authors.initials: P
authors.lastname: Karim
authors.affiliation: a Health Research Center.
authors.forename: Afshari
authors.initials: A
authors.lastname: Hossein
authors.affiliation: a Health Research Center.
authors.forename: Rostami
authors.initials: R
authors.lastname: Leila
authors.affiliation: a Health Research Center.
authors.forename: Mahmoudi
authors.initials: M
authors.lastname: Hamdollah
authors.affiliation: b Baqiyatallah Research Center for Gastroenterology and Liver Disease.
authors.forename: Ghamarchehreh
authors.initials: G
authors.lastname: Mohammad E
authors.affiliation: c Department of Epidemiology and Biostatistics , Health School.
authors.forename: Sepandi
authors.initials: S
authors.lastname: Mojtaba
authors.affiliation: d Exercise Physiology Research Center.
authors.forename: Samadi
authors.initials: S
authors.lastname: Mohammad
authors.affiliation: a Health Research Center.
authors.forename: Ghanizadeh
authors.initials: G
authors.lastname: Ghader
authors.affiliation: b Baqiyatallah Research Center for Gastroenterology and Liver Disease.
authors.forename: Alavian
authors.initials: A
authors.lastname: Seyed Moayed
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis*; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D000069196:Gastrointestinal Microbiome / Q000502:physiology; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D010919:Placebos; D019936:Probiotics / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D015850:Interleukin-6; D010919:Placebos; D014409:Tumor Necrosis Factor-alpha; C517652:hemoglobin A1c protein, human
keywords: blood glucose; cytokines; fatty liver; probiotic