title: Ischemic placental syndrome--prediction and new disease monitoring.
abstract: The last decade has seen an improved understanding of the cause of the development of pathologies such as gestational hypertension, preeclampsia, intrauterine growth restriction, intrauterine fetal death or placental abruption. Nowadays, we know that most conditions within this group share the same pathogenesis, the cause of which is placental ischemia. The following review is an attempt to propose a new method for prediction, diagnosis and--above all--appropriate monitoring of pregnant women and fetuses developing the ischemic placental syndrome with the use of tests that are new but yet widely available in clinical diagnosis. They are closely related to the condition's pathogenesis, therefore their elevated levels may predate clinical symptoms, and--most importantly--they correlate with syndrome aggravation and the occurrence of complications. Perhaps, the new look will allow us to improve perinatal results by reducing mortality and severe complications in pregnant women and fetal deaths resulting from sudden intrauterine fetal death or placental abruption.
authors.affiliation: a Department of Gynecology and Obstetrics .
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kwiatkowski
authors.affiliation: b Department of Nephrology , Transplantology and Internal Medicine , and.
authors.forename: Ewa
authors.initials: E
authors.lastname: Kwiatkowska
authors.affiliation: a Department of Gynecology and Obstetrics .
authors.forename: Rafał
authors.initials: R
authors.lastname: Rzepka
authors.affiliation: a Department of Gynecology and Obstetrics .
authors.forename: Andrzej
authors.initials: A
authors.lastname: Torbe
authors.affiliation: c Department of Laboratory Diagnostics , Pomeranian University of Medicine , Szczecin , Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Dolegowska
mesh_terms: D015415:Biomarkers; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000209:etiology; D010922:Placenta Diseases / Q000175:diagnosis* / Q000209:etiology; D011247:Pregnancy
chemical_list: D015415:Biomarkers
keywords: Abruptio placenta; CRP; IUGR; fibronectin; preeclampsia; sFlt