title: [History of incompability among medicinals of "Glycyrrhiza antagonistic to Sargassum, Euphorbia Pekinensis, Kansui, and Genkwa" and its modern recognition].
abstract: The allegation of "Glycyrrhiza antagonistic to Sargassum, Euphorbia Pekinensis, Kansui, and Genkwa", being one of the hypotheses of "18 antagonisms" in TCM pharmacology, is referring to the antagonistic action among the Radix et Rhizoma Glycyrrhiza and Radix Euphorbiae Kansui, Radix Euphorbiae Pekinensis, Flos Genkwa, and Sargassum when compounded together in a single recipe. By reviewing its history concerted with modern knowledge, it can be found that the theory of "seven emotions" was originated from Shennong's Classic of Materia Medica; while the Variorum of the Classic of Materia Medica firstly and definitely records that Radix et Rhizoma Glycyrrhizae is forbidden to be used with Radix Kansui, Flos Genkwa, Radix Euphorbiae Pekinensis, Sargassum together in a single formula. It was summarized into a Chinese poetic sentence as above-mentioned later. In the works of later ages, including Chinese Pharmacopoeia, A Great Dictionary of Chinese Materia Medica, and China's Herbology, etc., all enhance the understanding of the prohibited combination of Radix et Rhizoma Glycyrrhizae and its incompatible herbs. Nevertheless, there are discrepancies between the results of modern experimental and clinical studies on this problem, which, needless to say, should be resolved by further investigations.
authors.affiliation: Foreign Language College, Nanjing, 210023, China.
authors.forename: Chenxue
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Institute of Literature in Chinese Medicine, Nanjing, 210023, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Bian
authors.affiliation: School of Basic Medical Science, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Fan
mesh_terms: D002681:China; D032364:Daphne / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000266:history / Q000494:pharmacology / Q000592:standards; D028481:Euphorbia / Q000737:chemistry; D006035:Glycyrrhiza / Q000737:chemistry*; D049668:History, 15th Century; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D049691:History, Medieval; D008419:Materia Medica / Q000266:history*; D008516:Medicine, Chinese Traditional / Q000266:history* / Q000592:standards; D018517:Plant Roots / Q000737:chemistry; D044647:Sargassum / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D008419:Materia Medica