title: Association between methicillin-resistant Staphylococcus pseudintermedius carriage and the development of surgical site infections following tibial plateau leveling osteotomy in dogs.
abstract: OBJECTIVE
  To evaluate the association between preoperative carriage of methicillin-resistant Staphylococcus pseudintermedius (MRSP) and the development of surgical site infections (SSIs) following tibial plateau leveling osteotomy (TPLO) in dogs.
  
  
  METHODS
  Prospective multicenter study.
  
  
  METHODS
  549 dogs.
  
  
  METHODS
  At 7 veterinary hospitals, swab specimens were obtained from the pharynx, nares, rectum, and skin of dogs admitted for TPLO. Specimens were submitted for culture of MRSP. For each dog, information regarding preoperative and postoperative antimicrobial administration, comorbidities, contact with other dogs, and whether the dog developed an SSI was obtained. Univariable and multivariable analyses were performed to identify variables associated with preoperative and postoperative MRSP colonization and the development of an SSI.
  
  
  RESULTS
  Of the 549 study dogs, 24 (4.4%) were identified as MRSP carriers before TPLO and 37 (6.7%) developed an SSI after TPLO. Bacteriologic culture was performed on specimens obtained from 32 of the 37 SSIs, and MRSP was isolated from 11 (34%). Carriers of MRSP (OR, 6.72; 95% confidence interval [CI], 2.12 to 21.4) and Bulldogs (OR, 11.1; 95% CI, 2.07 to 59.3) were at risk for development of an SSI after TPLO, whereas postoperative administration of antimicrobials (OR, 0.36; 95% CI, 0.15 to 0.91) appeared to protect against development of an SSI.
  
  
  CONCLUSIONS
  Results indicated that carriage of MRSP were a risk factor for development of an SSI after TPLO and measures to rapidly identify and treat MRSP carriers are warranted. Postoperative administration of antimicrobials protected against development of an SSI after TPLO.
authors.forename: Alim
authors.initials: A
authors.lastname: Nazarali
authors.forename: Ameet
authors.initials: A
authors.lastname: Singh
authors.forename: Noel M M
authors.initials: NM
authors.lastname: Moens
authors.forename: Matthieu
authors.initials: M
authors.lastname: Gatineau
authors.forename: Colin
authors.initials: C
authors.lastname: Sereda
authors.forename: David
authors.initials: D
authors.lastname: Fowler
authors.forename: Stanley E
authors.initials: SE
authors.lastname: Kim
authors.forename: Agatha
authors.initials: A
authors.lastname: Kisiel
authors.forename: Debbie
authors.initials: D
authors.lastname: Reynolds
authors.forename: Brendon R
authors.initials: BR
authors.lastname: Ringwood
authors.forename: Charles W
authors.initials: CW
authors.lastname: Bruce
authors.forename: Thomas W G
authors.initials: TW
authors.lastname: Gibson
authors.forename: Joyce
authors.initials: J
authors.lastname: Rousseau
authors.forename: J Scott
authors.initials: JS
authors.lastname: Weese
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000209:etiology / Q000382:microbiology*; D004285:Dogs; D005260:Female; D008297:Male; D016106:Methicillin Resistance; D010027:Osteotomy / Q000009:adverse effects / Q000662:veterinary*; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000382:microbiology / Q000662:veterinary*; D013210:Staphylococcus / Q000187:drug effects*; D013530:Surgical Wound Infection / Q000382:microbiology / Q000662:veterinary*; D013977:Tibia / Q000601:surgery