title: Compromised Prefrontal Cognitive Control Over Emotional Interference in Adolescents with Internet Gaming Disorder.
abstract: Increased reports of impulsivity and aggression in male adolescents with Internet gaming might reflect their dysfunction in emotion regulation, particularly in suppression of negative emotions, which should affect the various stages of Internet gaming disorder. This study tested the hypothesis that adolescents with Internet gaming disorder would be more disturbed by the emotional interference and demonstrate compromised dorsal anterior cingulate cortex (dACC) activation during a Stroop Match-to-Sample task. In addition, functional connectivity analysis was conducted to examine the interplays between neural correlates involved in emotional processing and how they were altered in adolescents with Internet gaming disorder. The Internet gaming disorder group demonstrated weaker dACC activation and stronger insular activations to interfering angry facial stimuli compared with the healthy control group. Negative functional connectivity between stronger insular activation and weaker dorsolateral prefrontal activation correlated with higher cognitive impulsivity in adolescents with Internet gaming disorder. These findings provide evidence of the compromised prefrontal cognitive control over emotional interference in adolescents with Internet gaming disorder.
authors.affiliation: 1 Department of Psychiatry, Yonsei University College of Medicine , Seoul, South Korea .|2 Institute of Behavioral Science in Medicine, Yonsei University College of Medicine , Seoul, South Korea .
authors.forename: Junghan
authors.initials: J
authors.lastname: Lee
authors.affiliation: 2 Institute of Behavioral Science in Medicine, Yonsei University College of Medicine , Seoul, South Korea .
authors.forename: Seojung
authors.initials: S
authors.lastname: Lee
authors.affiliation: 3 Department of Psychiatry, Catholic University of Korea College of Medicine , Seoul, South Korea .
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Chun
authors.affiliation: 3 Department of Psychiatry, Catholic University of Korea College of Medicine , Seoul, South Korea .
authors.forename: Hyun
authors.initials: H
authors.lastname: Cho
authors.affiliation: 3 Department of Psychiatry, Catholic University of Korea College of Medicine , Seoul, South Korea .
authors.forename: Dai-jin
authors.initials: DJ
authors.lastname: Kim
authors.affiliation: 1 Department of Psychiatry, Yonsei University College of Medicine , Seoul, South Korea .|2 Institute of Behavioral Science in Medicine, Yonsei University College of Medicine , Seoul, South Korea .
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Jung
mesh_terms: D000293:Adolescent; D016739:Behavior, Addictive / Q000503:physiopathology / Q000523:psychology*; D001931:Brain Mapping; D002648:Child; D003071:Cognition / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007175:Impulsive Behavior / Q000502:physiology*; D020407:Internet; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology*