title: Non-motor symptoms and quality of life in patients with Parkinson's disease in Northeastern Mexico.
abstract: Parkinson's disease (PD) is a multisystem disorder, and besides the classical motor symptoms it is now known that patients also suffer from a variety of non-motor symptoms that adversely affect quality of life (QOL). Since data on Hispanic populations on this issue are scarce, our aim was to study the association of non-motor symptoms and QOL in patients with PD. This study is a cross-sectional observational study involving patients with PD using the following instruments: Quality of Life Questionnaire (PDQ-8), Unified Parkinson's Disease Rating Scale part III (UPDRS part III), and Non-Motor Symptom Scale (NMSS). We included 52 patients, with a median age of 64 years. Sleep/fatigue and mood/cognitive domains were the most common non-motor symptoms. Only sleep/fatigue, mood/cognition and gastrointestinal domains were associated with worse PDQ-8 scores. After adjusting for confounding variables, NMSS scores were significantly associated with a high PDQ-8 score. Higher NMSS scores were associated with and predicted higher PDQ-8 scores. The focus of management in PD should shift to a comprehensive strategy that incorporates care of non-motor symptoms and improves QOL.
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64700, Monterrey, Nuevo León, Mexico.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Estrada-Bellmann
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64700, Monterrey, Nuevo León, Mexico. crcamara83@hotmail.com.
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Camara-Lemarroy
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64700, Monterrey, Nuevo León, Mexico.
authors.forename: Hector J
authors.initials: HJ
authors.lastname: Calderon-Hernandez
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64700, Monterrey, Nuevo León, Mexico.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Rocha-Anaya
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64700, Monterrey, Nuevo León, Mexico.
authors.forename: Hector J
authors.initials: HJ
authors.lastname: Villareal-Velazquez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology / Q000209:etiology; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology*; D015995:Prevalence; D011788:Quality of Life; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000209:etiology; D011795:Surveys and Questionnaires
keywords: Cognition; Non-motor symptoms; Parkinson’s disease; Quality of life; Sleep