title: Physicochemical and functional performance of pectin extracted by QbD approach from Tamarindus indica L. pulp.
abstract: The aim of present investigation was to utilize quality by design (QbD) approach for extraction of tamarind pectin (TP) from Tamarindus indica L. pulp employing purity descriptors as indicator. The software generated quadratic equations showed significant effect of polarity index as compared to pulp concentration and boiling temperature on percentage yield and purity characteristics of TP. An insignificant effect on purity descriptors and percentage yield of TP upon replacement of acetone with methanol during predicted vs observed correlation studies (being similar polarity index of 5.1) pointed towards overwhelming influence of solvent polarity. Further, the FTIR-ATR, (1)H NMR, DSC and mass spectroscopy suggested TP was rhamnogalacturonan pectin with no tartaric acid content. TP was found to have significantly higher antioxidant activity as compare to apple pomace pectin, citrus peel pectin and commercial pectin. Overall, the physicochemical properties and antioxidant potential of TP could be utilized as an excipient for food and pharmaceutical industry.
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
authors.forename: Radhika
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kamboj
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
authors.forename: Rajneet
authors.initials: R
authors.lastname: Khurana
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
authors.forename: Gursharan
authors.initials: G
authors.lastname: Singh
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India. Electronic address: vikas_pbi@rediffmail.com.
authors.forename: Vikas
authors.initials: V
authors.lastname: Rana
mesh_terms: D002240:Carbohydrate Sequence; D005591:Chemical Fractionation / Q000379:methods*; D008969:Molecular Sequence Data; D010368:Pectins / Q000737:chemistry* / Q000302:isolation & purification*; D012212:Rheology; D029861:Tamarindus / Q000737:chemistry*
chemical_list: D010368:Pectins
keywords: Antioxidant activity; Characterization; Design of experiments; Rhamnogalacturonan; Tamarind pectin