title: Role of linezolid therapeutic drug monitoring in the treatment of MRSA tracheo-pulmonary infection in a 10-month-old infant.
abstract: The paper reports on the use of therapeutic drug monitoring for linezolid in the decision-making process to continue or not its administration in an infant. Linezolid is effective against methicillin-resistant Staphylococcus aureus but is off-label in pediatrics. The use of therapeutic drug monitoring, as in our case, allows an informed decision on administration of the drug (in this case on withdrawal) increasing patients safety.
authors.affiliation: a Infectious Diseases Unit , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genoa , Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Castagnola
authors.affiliation: b Laboratory of Analysis , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genoa , Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Cangemi
authors.affiliation: b Laboratory of Analysis , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genoa , Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bandettini
authors.affiliation: c Tracheal Surgery Team , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genoa , Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Torre
authors.affiliation: d Cardiological Surgery Unit , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genoa , Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Zannini
authors.affiliation: e Intensive Care Unit , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genoa , Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Tuo
authors.affiliation: e Intensive Care Unit , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genoa , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Moscatelli
mesh_terms: D000900:Anti-Bacterial Agents / Q000097:blood / Q000627:therapeutic use*; D016903:Drug Monitoring; D006801:Humans; D007223:Infant; D000069349:Linezolid / Q000097:blood / Q000627:therapeutic use*; D008171:Lung Diseases / Q000097:blood / Q000188:drug therapy*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D013203:Staphylococcal Infections / Q000097:blood / Q000188:drug therapy*; D014133:Tracheal Diseases / Q000097:blood / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000069349:Linezolid
keywords: Linezolid; Paediatrics; Therapeutic drug monitoring