title: Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review.
abstract: Cholestyramine is a bile acid sequestrant that has been used in the treatment of hypercholesterolemia, pruritus due to elevated bile acid levels, and diarrhea due to bile acid malabsorption. This medication can rarely cause hyperchloremic nonanion gap metabolic acidosis, a complication featured in this report of an adult male with concomitant acute kidney injury. This case emphasizes the caution that must be taken in prescribing cholestyramine to patients who may also be volume depleted, in renal failure, or taking spironolactone.
authors.affiliation: University of Calgary, Suite G15, 1403-29 Street NW, Calgary, AB, Canada T2N 2T9.
authors.forename: Fareed B
authors.initials: FB
authors.lastname: Kamar
authors.affiliation: University of Toronto and University Health Network, Toronto General Hospital, Room 8N-842, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4.
authors.forename: Rory F
authors.initials: RF
authors.lastname: McQuillan