title: Fucoxanthin Inhibits the Inflammation Response in Paw Edema Model through Suppressing MAPKs, Akt, and NFκB.
abstract: Undaria pinnatifida is a well-known traditional Korean food with a variety of biological activities. Carrageenan (carr) is commonly used to induce paw edema in animal models. This study was designed to elucidate the processes underlying the anti-inflammatory effect of fucoxanthin isolated from the sporophyll of U. pinnatifida in carr-induced paw edema in ICR mice. Fucoxanthin significantly decreased carr-induced increased nitric oxide levels in the plasma of mice with carr-induced paw edema. Fucoxanthin protected catalase (CAT) and superoxide dismutase (SOD) activity against disruption in mice with carr-induced paw edema. In addition, fucoxanthin repressed carr-induced activation of inducible nitric oxide synthase, cyclooxygenase-2, and nuclear factor kappa B, as well as carr-induced phosphorylation of mitogen-activated protein kinase, extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38, and protein kinase B/Akt. These results suggest that fucoxanthin may have therapeutic potential as a treatment for patients with inflammatory diseases.
authors.affiliation: Department of Bio-Health Science, Gwangju University, Gwangju, 503-703, Republic of Korea.
authors.forename: Jun-Hui
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Bio-Health Science, Gwangju University, Gwangju, 503-703, Republic of Korea.
authors.forename: Na-Hyun
authors.initials: NH
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science, Chosun University, Gwangju, 501-759, Republic of Korea.
authors.forename: Sung-Jun
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Bio-Health Science, Gwangju University, Gwangju, 503-703, Republic of Korea.
authors.forename: Hyo-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Bio-Health Science, Gwangju University, Gwangju, 503-703, Republic of Korea. seungk@gwangju.ac.kr.
authors.forename: Seung
authors.initials: S
authors.lastname: Kim
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D004487:Edema / Q000517:prevention & control; D007249:Inflammation / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D009569:Nitric Oxide / Q000097:blood; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors*; D013482:Superoxide Dismutase / Q000378:metabolism; D024341:Xanthophylls / Q000494:pharmacology*
chemical_list: D016328:NF-kappa B; D024341:Xanthophylls; C025164:fucoxanthin; D009569:Nitric Oxide; D002374:Catalase; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; D013482:Superoxide Dismutase; D051057:Proto-Oncogene Proteins c-akt; D020928:Mitogen-Activated Protein Kinases
keywords: Anti-inflammation; Carrageenan; Fucoxanthin; Mitogen-activated protein kinases; Undaria pinnatifida (Harvey) Suringar