title: A high stiffness bio-inspired hydrogel from the combination of a poly(amido amine) dendrimer with DOPA.
abstract: A robust biodegradable hydrogel is constructed from two components containing G4.0 PAMAM and DOPA, which displays excellent interconnected porous 3D networks, higher mechanical strength, low and stable swelling and good biocompatibility. A mouse CSD model in vivo evidences that moderate bone-like tissue and extensive bony tissue are observed when the hydrogel is implanted.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. xrjia@pku.edu.cn and Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, Peking University, Beijing 100871, P. R.China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. xrjia@pku.edu.cn and State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Peking University, Beijing 100871, P. R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. xrjia@pku.edu.cn and Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, Peking University, Beijing 100871, P. R.China.
authors.forename: Yiyang
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. xrjia@pku.edu.cn and Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, Peking University, Beijing 100871, P. R.China.
authors.forename: Zejun
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, College of Stomatology, Chongqing Medical University, Chongqing 400016, P. R. China. ysdentist@hotmail.com.
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, College of Stomatology, Chongqing Medical University, Chongqing 400016, P. R. China. ysdentist@hotmail.com.
authors.forename: Sheng
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. xrjia@pku.edu.cn and Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, Peking University, Beijing 100871, P. R.China.
authors.forename: Xinru
authors.initials: X
authors.lastname: Jia
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000737:chemistry*; D004295:Dihydroxyphenylalanine / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D055595:Mechanical Phenomena; D051379:Mice; D016062:Porosity
chemical_list: D050091:Dendrimers; C104700:PAMAM Starburst; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D004295:Dihydroxyphenylalanine