title: [A Case of Repetitive Cardiac Arrest due to Coronary Vasospasm after Sugammadex Administration].
abstract: A 58-year-old man with no history of cardiac disease was scheduled for a cerebral aneurysm clipping surgery. Anesthesia was administered with propofol, rocuronium, fentanyl, and remifentanil. At the end of the surgery, extubation was performed 3 min after the administration of 200 mg sugammadex, along with a simultaneous blood-pressure decrease with ST elevation on lead II. Cardiopulmonary resuscitation was per- formed owing to the occurrence of lethal arrhythmia, and the patient was successfully resuscitated. Subsequent emergent coronary angiography revealed normal coronary arteries. Twelve days after the first surgery, a tracheostomy was performed owing to persistent disturbance of consciousness. Anesthesia was administered with sevoflurane, fentanyl, and rocuronium. Sugammadex 200 mg was administered after the insertion of a tracheal cannula, and 5 min later, the blood pressure were gradually decreased with ST depression on lead V5. Finally, cardiopulmonary resuscitation was required, and the patient recovered again. An acetylcholine provocation test performed later showed positive results. We suspect sugammadex to be the cause of coronary vasospasm, because the time courses of the two cardiac arrest episodes after sugammadex administration were very similar. Therefore, clinicians should consider sugammadex as one of the causative agents of cardiac arrest in the operating room.
authors.forename: Koji
authors.initials: K
authors.lastname: Hoshino
authors.forename: Rui
authors.initials: R
authors.lastname: Kato
authors.forename: Sayaka
authors.initials: S
authors.lastname: Nagasawa
authors.forename: Masahito
authors.initials: M
authors.lastname: Kozu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000503:physiopathology; D004562:Electrocardiography; D006323:Heart Arrest / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012151:Resuscitation; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000009:adverse effects*
chemical_list: D047408:gamma-Cyclodextrins; D000077122:Sugammadex