title: Metastatic Adenocarcinoma of Unknown Origin Presenting as Small Bowel Perforation: A Case Report and Literature Review.
abstract: Metastatic malignant tumors that originate from occult primaries are defined as "cancers of unknown origin." We herein present the case of a 59-year-old man who presented with small bowel perforation secondary to metastatic adenocarcinoma of an unknown primary site. Imaging exhibited two pulmonary nodules, neither of which was dominant, along with mediastinal and retroperitoneal lymphadenopathy. Immunohistochemical profiling of the small bowel biopsy specimens revealed the tumor was most likely pulmonary in origin.
authors.affiliation: Northwest Hospital, Randallstown, MD, USA ; Saba University School of Medicine, Devens, MA, USA.
authors.forename: Samir
authors.initials: S
authors.lastname: Alkabie
authors.affiliation: Northwest Hospital, Randallstown, MD, USA ; Sinai Hospital, Baltimore, MD, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Bello
authors.affiliation: Sinai Hospital, Baltimore, MD, USA.
authors.forename: Roberto F
authors.initials: RF
authors.lastname: Martinez
authors.affiliation: Northwest Hospital, Randallstown, MD, USA.
authors.forename: W Peter
authors.initials: WP
authors.lastname: Geis
authors.affiliation: Northwest Hospital, Randallstown, MD, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Ballo
keywords: cancer of unknown primary site; diagnosis; immunohistochemistry; metastatic adenocarcinoma; occult primary; pulmonary primary; small bowel perforation