title: Pseudogenes in Human Cancer.
abstract: Recent advances in the analysis of RNA sequencing data have shown that pseudogenes are highly specific markers of cell identity and can be used as diagnostic and prognostic markers. Furthermore, genetically engineered mouse models have recently provided compelling support for a causal link between altered pseudogene expression and cancer. In this review, we discuss the most recent milestones reached in the pseudogene field and the use of pseudogenes as cancer classifiers.
authors.affiliation: Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori , Pisa , Italy ; Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche , Pisa , Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Poliseno
authors.affiliation: Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori , Pisa , Italy ; University of Siena , Siena , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Marranci
authors.affiliation: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA , USA.
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Pandolfi
keywords: animal models of cancer; cancer; ceRNAs; diagnostic markers; mutagenic factors; prognostic markers; pseudogenes