title: The Influence of Diabetes Mellitus on Proliferation and Osteoblastic Differentiation of MSCs.
abstract: BACKGROUND
  Diabetes mellitus (DM) is a widespread chronic metabolic disease which has high mortality due to its complications. In addition to traditional medication, stem cell transplantation therapeutics has become a brand-new and prospective remedy for DM. With strong self-renewal and multi-potential ability, mesenchymal stem cells (MSCs) are considered as ideal cell sources of cell therapy for DM and many other diseases. However, not only do endogenous MSCs fail to replace the impaired islet cells, but also transplanted MSCs fail to cure many patients complicated with DM. Besides, quite a few DM patients suffer from high risk of fracture and low efficiency of bone regeneration, which are often associated with the osteoblastic differentiation of MSCs. Recently, a number of researches have investigated that the changes in micro-environment by DM can affect biological characteristics of MSCs through many factors.
  
  
  CONCLUSIONS
  In this review, we summarize the developments in the influence of DM on proliferation and osteoblastic differentiation of MSCs, and moreover, osteoporosis, obesity and metabolism syndrome, as they are closely related to DM.
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.|Shaanxi Key Laboratory of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.|Department of Stomatology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, P.R.China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tan
authors.affiliation: Department of Stomatology, General Hospital of Beijing Military Area, Beijing, P.R.China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Anesthesiology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, P.R.China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.|Shaanxi Key Laboratory of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xue
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.|Shaanxi Key Laboratory of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.|Department of Stomatology, Qingdao First Sanatorium of Jinan Military Area Command, Qingdao, Shandong, P.R.China.
authors.forename: Guangsheng
authors.initials: G
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.|Shaanxi Key Laboratory of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.
authors.forename: Guangying
authors.initials: G
authors.lastname: Dong
authors.affiliation: Department of Anesthesiology, General Hospital of Beijing Military Area, Beijing, P.R.China.
authors.forename: Hang
authors.initials: H
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.|Shaanxi Key Laboratory of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R.China.
authors.forename: Qintao
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D002454:Cell Differentiation; D049109:Cell Proliferation; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D010012:Osteogenesis
keywords: Diabetes mellitus; mesenchymal stem cells; metabolism syndrome; obesity; osteoblastic differentiation; osteoporosis; proliferation