title: Semiquantitative and Quantitative Analyses of Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Thyroid Nodules.
abstract: OBJECTIVE
  This study was aimed to determine the utility of quantitative dynamic contrast-enhanced magnetic resonance imaging (MRI) in differentiating benign and malignant lesions in patients with known thyroid gland lesions scheduled for resection.
  
  
  METHODS
  Patients scheduled for resection of a thyroid mass were prospectively enrolled. Dynamic contrast-enhanced MRI scans of the neck were performed before surgery. After resection, patients were divided into benign and malignant groups. Quantitative and semiquantitative MRI kinetic measurements of benign and malignant lesions were compared and analyzed.
  
  
  RESULTS
  Twelve benign and 9 malignant lesions were identified in 19 patients. Mean Ktrans, Ve, and Kep for benign lesions were 1.69 ± 1.59 min, 0.44 ± 0.21 min, and 4.51 ± 2.96 min, respectively; for the malignant lesions, 0.96 ± 0.57 min, 0.45 ± 0.19 min, and 3.57 ± 3.53 min, respectively (P = 0.1886, 0.8036, and 0.3028, respectively). Tpeak, ERmax, slopemax, and iAUGC60 for benign lesions were 7.00 ± 8.09 seconds, 293.27 ± 141.25 seconds, 76.45 ± 65.80 seconds, and 63.46 ± 46.84, respectively; for malignant lesions, 8.11 ± 8.55 seconds, 227.6 ± 113.37 seconds, 81.17 ± 109.71 seconds, and 43.69 ± 26.19, respectively (P = 0.7525, 0.4941, 0.4474, and 0.3028, respectively).
  
  
  CONCLUSIONS
  Dynamic contrast-enhanced MRI pattern of kinetics was not significantly different for benign and malignant lesions of the thyroid using quantitative or semiquantitative methods.
authors.affiliation: From the *Department of Radiology, †Division of Otolaryngology-Head and Neck Surgery, and ‡Department of Pathology, The George Washington University Medical Center, Washington, DC; §iCAD, Inc, Nashua, NH; and ∥Department of Epidemiology and Biostatistics, The George Washington University, Washington, DC.
authors.forename: Eliel
authors.initials: E
authors.lastname: Ben-David
authors.forename: Nader
authors.initials: N
authors.lastname: Sadeghi
authors.forename: M Katayoon
authors.initials: MK
authors.lastname: Rezaei
authors.forename: Naira
authors.initials: N
authors.lastname: Muradyan
authors.forename: Derek
authors.initials: D
authors.lastname: Brown
authors.forename: Arjun
authors.initials: A
authors.lastname: Joshi
authors.forename: M Reza
authors.initials: MR
authors.lastname: Taheri
mesh_terms: D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies; D016606:Thyroid Nodule / Q000473:pathology*
chemical_list: D003287:Contrast Media