title: In vitro methods for screening transdermal formulations.
abstract: This article provides a review of the critical in vitro assays utilized in transdermal drug development. In vitro assays such as percutaneous absorption testing and dissolution (drug release) testing are powerful tools for screening potential transdermal compounds and drug quality control, respectively. Several 2D single-cell cultures and 3D human skin equivalents are available for screening compounds with low irritation and sensitization potential. The role of each assay and its limitations and challenges will be further discussed below.
authors.affiliation: Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers - The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.|The Center for Dermal Research, New Jersey Center for Biomaterials, Rutgers - The State University of New Jersey, 145 Bevier Rd, Piscataway, NJ 08854, USA.
authors.forename: Pei-Chin
authors.initials: PC
authors.lastname: Tsai
authors.affiliation: Department of Biomedical Engineering, Rutgers - The State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA.
authors.forename: Serom
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers - The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.|The Center for Dermal Research, New Jersey Center for Biomaterials, Rutgers - The State University of New Jersey, 145 Bevier Rd, Piscataway, NJ 08854, USA.
authors.forename: Bozena
authors.initials: B
authors.lastname: Michniak-Kohn
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D006801:Humans; D066298:In Vitro Techniques; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry; D012867:Skin / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D012869:Skin Absorption
chemical_list: D004364:Pharmaceutical Preparations