title: Amphotericin B Resistant Apophysomyces elegans Causing Rhino-oculo-Cerebral Mucormycosis in an Immunocompetent Host.
abstract: Mucormycosis, an angioinvasive infection is caused by the ubiquitous filamentous fungi of the order Mucorales and class Mucormycetes. Reports of this disease are on the rise over the past few decades. Rhino-oculo-Cerebral presentation associated with uncontrolled diabetes is the predominant characteristic of this entity. We report here a case of rhinooculocerebral mucormycosis (ROCM) due to Apophysomyces elegans (A. elegans) in a 45-year-old diabetic lady with background illness of hypothyroidism and polyradiculoneuropathy. Though this condition is usually managed with surgical debridement of the affected tissue and medical therapy with Amphotericin B, the isolate recovered in our case was found to be resistant to Amphotericin B.
authors.affiliation: Professor, Department of Microbiology, Himalayan Institute of Medical Sciences , Jolly Grant, Dehradun, India; Additional Professor, Department of Microbiology, AIIMS Bhopal, Bhopal, India .
authors.forename: Debasis
authors.initials: D
authors.lastname: Biswas
authors.affiliation: Associate Professor, Department of Microbiology, Himalayan Institute of Medical Sciences , Jolly Grant, Dehradun, India .
authors.forename: Aarti
authors.initials: A
authors.lastname: Kotwal
authors.affiliation: Associate Professor, Department of Microbiology, Himalayan Institute of Medical Sciences , Jolly Grant, Dehradun, India .
authors.forename: Barnali
authors.initials: B
authors.lastname: Kakati
authors.affiliation: Professor, Department of Medicine, Himalayan Institute of Medical Sciences , Jolly Grant, Dehradun, India .
authors.forename: Sohaib
authors.initials: S
authors.lastname: Ahmad
keywords: Antifungal susceptibility profile; Diabetes; Mucormycosis