title: Placental expression of D6 decoy receptor in preeclampsia.
abstract: OBJECTIVE
  The purpose of this study was to investigate the expression of the D6 decoy receptor that can bind chemokines and target them for degradation, resulting in inhibition of inflammation in placentas from preeclamptic and normal pregnancies.
  
  
  METHODS
  The current study was carried out in 35 pregnant women (23 patients with preeclampsia and 12 healthy, normotensive pregnant women) during the third trimester of pregnancy. The expressions of D6 decoy receptor in the placenta were determined with real time reverse transcriptase polymerase chain reaction and western blotting.
  
  
  RESULTS
  The mRNA and protein of D6 decoy receptor were detected in all of placentas from preeclamptic and normal pregnancies. Placental D6 decoy receptor mRNA expression was significantly lower in patients with preeclampsia than in patients with normal pregnancies. Western blot analyses revealed decreased protein expression in cases of preeclampsia.
  
  
  CONCLUSIONS
  The expression of the D6 decoy receptor in preeclamptic placentas was significantly lower than in normal placentas. Further studies are needed to clarify the underlying mechanisms that link decreased expression of placental D6 decoy receptor and preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Geum Joon
authors.initials: GJ
authors.lastname: Cho
authors.affiliation: Department of Obstetrics and Gynecology, Bundang Cheil Women's Hospital, Seongnam, Korea.
authors.forename: Eun Sung
authors.initials: ES
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hye Mi
authors.initials: HM
authors.lastname: Jin
authors.affiliation: Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Yeun Sun
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Oh
authors.affiliation: Department of Obstetrics and Gynecology, Kyunghee University College of Medicine, Seoul, Korea.
authors.forename: Hyun-Joo
authors.initials: HJ
authors.lastname: Seol
authors.affiliation: Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Soon-Cheol
authors.initials: SC
authors.lastname: Hong
authors.affiliation: Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hai-Joong
authors.initials: HJ
authors.lastname: Kim
keywords: D6 decoy receptor; Placenta; Preeclampsia