title: Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy.
abstract: The amidation reaction between C60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C60 compound (3). The water soluble deacetylated compound, Glc-pendant C60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.
authors.affiliation: Graduate School of Material Science, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0192, Japan. yano-shigenobu@ms.naist.jp.
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Yano
authors.forename: Masami
authors.initials: M
authors.lastname: Naemura
authors.forename: Akio
authors.initials: A
authors.lastname: Toshimitsu
authors.forename: Motofusa
authors.initials: M
authors.lastname: Akiyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kikuchi
authors.forename: Xiande
authors.initials: X
authors.lastname: Shen
authors.forename: Qian
authors.initials: Q
authors.lastname: Duan
authors.forename: Atsushi
authors.initials: A
authors.lastname: Narumi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Inoue
authors.forename: Kei
authors.initials: K
authors.lastname: Ohkubo
authors.forename: Shunichi
authors.initials: S
authors.lastname: Fukuzumi
mesh_terms: D000107:Acetylation; D000577:Amides / Q000737:chemistry*; D002470:Cell Survival; D037741:Fullerenes / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D010778:Photochemotherapy; D026082:Singlet Oxygen / Q000737:chemistry*
chemical_list: D000577:Amides; D037741:Fullerenes; D026082:Singlet Oxygen; D005947:Glucose; C069837:fullerene C60