title: Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread.
abstract: A 61-year-old woman was referred to surgery for incidentally found colonic polyps during a health examination. Physical examination revealed widespread eczematous skin lesion without pruritus in the perianal and vulvar area. Abdominopelvic computed tomography showed an approximately 4-cm-sized, soft tissue lesion in the right perianal area. Inguinal lymph node dissection and Mils' operation extended to perianal and perivulvar skin was performed. Histologically, the anal canal lesion was composed of mucin-containing signet ring cells, which were similar to those found in Pagetoid skin lesions. It was diagnosed as an anal canal signet ring cell carcinoma (SRCC) with perianal and vulvar Pagetoid spread and bilateral inguinal lymph node metastasis. Anal canal SRCC is rare, and the current case is the third reported case in the English literature. Seven additional cases were retrieved from the world literature. Here, we describe this rare case of anal canal SRCC with perianal Pagetoid spread and provide a literature review.
authors.affiliation: Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Na Rae
authors.initials: NR
authors.lastname: Kim
authors.affiliation: Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Hyun Yee
authors.initials: HY
authors.lastname: Cho
authors.affiliation: Department of General Surgery, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Jeong-Heum
authors.initials: JH
authors.lastname: Baek
authors.affiliation: Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Juhyeon
authors.initials: J
authors.lastname: Jeong
authors.affiliation: Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Seung Yeon
authors.initials: SY
authors.lastname: Ha
authors.affiliation: Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Jae Yeon
authors.initials: JY
authors.lastname: Seok
authors.affiliation: Department of General Surgery, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Park
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Sun Jin
authors.initials: SJ
authors.lastname: Sym
authors.affiliation: Department of Radiation Oncology, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Kyu Chan
authors.initials: KC
authors.lastname: Lee
authors.affiliation: Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Dong Hae
authors.initials: DH
authors.lastname: Chung
keywords: Anal canal; Carcinoma, signet ring cell; Paget disease, extramammary