title: Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo.
abstract: Pigment epithelium-derived factor (PEDF) is a natural protein of the retina with demonstrable neurotrophic properties, found in the interphotoreceptor matrix in intimate contact with photoreceptors. This review summarizes the effects of PEDF on photoreceptors in several animal models of retinal degeneration.
authors.affiliation: Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, NIH-NEI BG.6. Room 134. 6 Center Drive MSC 0608, 20892-0608, Bethesda, MD, USA. polatof@mail.nih.gov.
authors.forename: Federica
authors.initials: F
authors.lastname: Polato
authors.affiliation: Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, NIH-NEI BG.6. Room 134. 6 Center Drive MSC 0608, 20892-0608, Bethesda, MD, USA. becerras@nei.nih.gov.
authors.forename: S Patricia
authors.initials: SP
authors.lastname: Becerra
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D009154:Mutation; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism*; D020419:Photoreceptor Cells, Vertebrate / Q000378:metabolism*; D020011:Protective Agents / Q000378:metabolism*; D012162:Retinal Degeneration / Q000235:genetics / Q000378:metabolism*; D015843:Serpins / Q000235:genetics / Q000378:metabolism*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D009414:Nerve Growth Factors; D020011:Protective Agents; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor
keywords: Animal models; Neuroprotection; PEDF; Photoreceptor; Retinal degeneration