title: [Testosterone deficiency, metabolic syndrome and diabetes mellitus].
abstract: Testosterone deficiency in adult age is associated with a decrease in libido, energy, hematocrit, muscle mass and bone mineral density, as well as with depression. More recently, testosterone deficiency has also been associated with various components of the metabolic syndrome, which in turn is associated with a five-fold increase in the risk of cardiovascular disease. Low testosterone levels are associated with increased insulin resistance, increase in fat mass, low HDL cholesterol, higher triglyceride levels and hypertension. Testosterone replacement therapy in patients with testosterone deficiency and type 2 diabetes mellitus and/or metabolic syndrome has shown reductions in insulin resistance, total cholesterol, LDL cholesterol and triglycerides and improvement in glycemic control and anthropometric parameters.
authors.affiliation: Servicio de Medina Interna-Endocrinología y Nutrición, Centre d́Atenció Integral Dos de Maig, Barcelona, España; Departamento de Medicina, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: Mercè
authors.initials: M
authors.lastname: Fernández-Miró
authors.affiliation: Departamento de Medicina, Universitat Autònoma de Barcelona, Barcelona, España; Servicio de Endocrinología y Nutrición, Hospital del Mar, Barcelona, España; Instituto Hospital del Mar de Investigaciones Médicas (IMIM), Barcelona, España. Electronic address: Jchillaron@parcdesalutmar.cat.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Chillarón
authors.affiliation: Departamento de Medicina, Universitat Autònoma de Barcelona, Barcelona, España; Servicio de Endocrinología y Nutrición, Hospital del Mar, Barcelona, España; Instituto Hospital del Mar de Investigaciones Médicas (IMIM), Barcelona, España.
authors.forename: Juan
authors.initials: J
authors.lastname: Pedro-Botet
mesh_terms: D050154:Adiposity; D000375:Aging / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism*; D004198:Disease Susceptibility; D042241:Early Diagnosis; D005058:Eunuchism / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D020249:Hormone Replacement Therapy; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology / Q000503:physiopathology; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D007006:Hypogonadism / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000378:metabolism*; D013739:Testosterone / Q000172:deficiency* / Q000627:therapeutic use
chemical_list: D013739:Testosterone
keywords: Déficit de testosterona; Hipogonadismo; Hipogonadismo y diabetes; Hypogonadism; Hypogonadism and diabetes; Testosterone deficiency