title: Hematopoietic Stem Cell Transplant for Mycosis Fungoides and Sézary Syndrome.
abstract: Mycosis fungoides (MF) and Sézary syndrome (SS) are common types of primary cutaneous T-cell lymphoma. Early-stage MF has a favorable prognosis and responds well to skin-directed regimens. Patients with advanced-stage MF, transformed MF, and SS are treated with combined systemic and skin-directed therapies. However, the disease is incurable with standard regimens, and frequent relapses are common. Owing to the lack of improvement in overall survival with standard regimens, hematopoietic stem cell transplant (HSCT) has been explored as a potential curative option. This article reviews the role of HSCT in MF/SS and discusses data regarding conditioning regimens, treatment-related complications, and outcomes.
authors.affiliation: Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 16 East 60th Street, New York, NY 10022, USA.
authors.forename: Pooja
authors.initials: P
authors.lastname: Virmani
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
authors.forename: Jasmine
authors.initials: J
authors.lastname: Zain
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Rosen
authors.affiliation: Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 16 East 60th Street, New York, NY 10022, USA.
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Myskowski
authors.affiliation: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA; Department of Pathology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA; Memorial Sloan Kettering Cancer Center, 16 East 60th Street, New York, NY 10022, USA. Electronic address: cquerfeld@coh.org.
authors.forename: Christiane
authors.initials: C
authors.lastname: Querfeld
mesh_terms: D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D017710:Lymphocyte Transfusion / Q000009:adverse effects; D009182:Mycosis Fungoides / Q000601:surgery*; D019653:Myeloablative Agonists / Q000009:adverse effects / Q000627:therapeutic use; D012751:Sezary Syndrome / Q000601:surgery*; D012878:Skin Neoplasms / Q000601:surgery*; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods; D014182:Transplantation, Autologous / Q000009:adverse effects / Q000379:methods; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000379:methods
chemical_list: D019653:Myeloablative Agonists
keywords: Allogeneic hematopoietic stem cell transplant; Autologous hematopoietic stem cell transplant; Cutaneous T-cell lymphoma; Mycosis fungoides; Myeloablative; Reduced-intensity conditioning; Sézary syndrome