title: Long-term stable lung function and second uncomplicated pregnancy on sirolimus in lymphangioleiomyomatosis (LAM).
abstract: We present a patient with lymphangioleiomyomatosis (LAM) on long-term sirolimus (now 79 months) who has had a second successful pregnancy. The second pregnancy on uninterrupted low-dose sirolimus (plasma levels 3-5 mg/L) was uncomplicated both with respect to mother and child suggesting that low-dose sirolimus might be safe in selected pregnant patients with stable LAM. The long-term time course in this patient is in agreement with recent reports of a long-term beneficial effect of sirolimus in LAM. In this patient, the pregnancies did not seem to impair the long-term improvement of lung-function on sirolimus.
authors.affiliation: Klinik für Kardiologie und Pneumologie, Klinikum Esslingen. familiefaehling@web.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Faehling
authors.forename: Vera
authors.initials: V
authors.lastname: Wienhausen-Wilke
authors.forename: Sabine
authors.initials: S
authors.lastname: Fallscheer
authors.forename: B
authors.initials: B
authors.lastname: Trinajstic-Schulz
authors.forename: J
authors.initials: J
authors.lastname: Weber
authors.forename: Matthias
authors.initials: M
authors.lastname: Leschke
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D050498:Live Birth; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D018192:Lymphangioleiomyomatosis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D010298:Parity; D011247:Pregnancy; D020127:Recovery of Function; D020123:Sirolimus / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D020123:Sirolimus