title: Modulation of embryonic development due to mating with immunised males.
abstract: The modification of pre- and postnatal development conferred by immunogenic stimulation of mothers provides a population-level adaptation mechanism for non-genetic transfer of maternal experiences to progeny. However little is known about the transmission of paternal immune experiences to offspring. Here, we show that immune priming of males 3-9 days before mating affects the growth and humoral environment of developing embryos of outbred (ICR) and inbred (C57BL and BALB/c) mice. Antigenic stimulation of fathers caused a significant increase in embryonic bodyweight as measured on Day 16 of pregnancy and altered other gestation parameters, such as feto-placental ratio. Pregnant females mated with immunised males were also characterised by changes in humoral conditions as shown by measurements of blood and amniotic progesterone, testosterone and granulocyte-macrophage colony-stimulating factor (GM-CSF) cytokine concentrations. These results emphasise the role of paternal effects of immune priming on the in utero environment and fetal growth.
authors.affiliation: Department of Genetic Resources of Experimental Animals, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akad. Lavrentieva 10, Novosibirsk 630090, Russia.
authors.forename: Ludmila A
authors.initials: LA
authors.lastname: Gerlinskaya
authors.affiliation: Department of Genetic Resources of Experimental Animals, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akad. Lavrentieva 10, Novosibirsk 630090, Russia.
authors.forename: Svetlana O
authors.initials: SO
authors.lastname: Maslennikova
authors.affiliation: Department of Genetic Resources of Experimental Animals, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akad. Lavrentieva 10, Novosibirsk 630090, Russia.
authors.forename: Margaret V
authors.initials: MV
authors.lastname: Anisimova
authors.affiliation: Department of Genetic Resources of Experimental Animals, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akad. Lavrentieva 10, Novosibirsk 630090, Russia.
authors.forename: Nataly A
authors.initials: NA
authors.lastname: Feofanova
authors.affiliation: Department of Genetic Resources of Experimental Animals, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akad. Lavrentieva 10, Novosibirsk 630090, Russia.
authors.forename: Evgenii L
authors.initials: EL
authors.lastname: Zavjalov
authors.affiliation: Department of Genetic Resources of Experimental Animals, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akad. Lavrentieva 10, Novosibirsk 630090, Russia.
authors.forename: Galina V
authors.initials: GV
authors.lastname: Kontsevaya
authors.affiliation: Department of Genetic Resources of Experimental Animals, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akad. Lavrentieva 10, Novosibirsk 630090, Russia.
authors.forename: Yuri M
authors.initials: YM
authors.lastname: Moshkin
authors.affiliation: Department of Genetic Resources of Experimental Animals, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akad. Lavrentieva 10, Novosibirsk 630090, Russia.
authors.forename: Mikhail P
authors.initials: MP
authors.lastname: Moshkin
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000653:Amniotic Fluid / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000276:immunology*; D047108:Embryonic Development / Q000187:drug effects / Q000276:immunology*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D006433:Hemocyanins / Q000008:administration & dosage*; D007114:Immunization; D008297:Male; D051379:Mice; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D012098:Reproduction / Q000187:drug effects / Q000276:immunology*; D013739:Testosterone / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D013739:Testosterone; D011374:Progesterone; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin