title: Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.
abstract: We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Olejniczak
authors.affiliation: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA. aalmutairi@ucsd.edu.
authors.forename: Viet Anh
authors.initials: VA
authors.lastname: Nguyen Huu
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Jacques
authors.initials: J
authors.lastname: Lux
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Grossman
authors.affiliation: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA. aalmutairi@ucsd.edu.
authors.forename: Sha
authors.initials: S
authors.lastname: He
authors.affiliation: Department of NanoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA. aalmutairi@ucsd.edu and Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
authors.forename: Adah
authors.initials: A
authors.lastname: Almutairi
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D004952:Esters / Q000737:chemistry / Q000528:radiation effects; D005452:Fluoresceins / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000528:radiation effects*; D009757:Nylons / Q000737:chemistry / Q000528:radiation effects*; D010078:Oxazines / Q000737:chemistry; D010782:Photolysis; D000067996:RAW 264.7 Cells
chemical_list: D004952:Esters; D005452:Fluoresceins; D005456:Fluorescent Dyes; D009757:Nylons; D010078:Oxazines; C044808:nile red; C018506:diacetylfluorescein