title: Comparison of clinical effect of dopamine and norepinephrine in the treatment of septic shock.
abstract: This study aims to compare the clinical effect of dopamine and nor epinephrine in the treatment of septic shock. Fifty cases with septic shock were randomly divided into two groups. Patients in both two groups revived after taking effective liquid. Then dopamine was pumped into central veins of patients in the research group (group DA) in 2 μ/(kg•min) upon the conventional treatment, while nor epinephrine was pumped into patients in the control group (group NE) in 0.1 μ/(kg•min), besides conventional treatment. The improvement of haemodynamics and microcirculation perfusion indexes were compared between two groups before and after treatment, as well as the improvement of tissue oxygen metabolism. The results demonstrated that, central venous pressure (CVP), mean arterial pressure (MAP), urine volume and central venous oxygen saturation (Scv O2) in both groups before treatment was not statistically significant (P>0.05); 6 h after treatment, CVP, MAP, urine volume and Scv O2 of group NE were higher than group DA; 12h and 24h after treatment, blood lactic acid clearance of group NE was superior than group DA (P<0.05). All the above findings suggested that, both dopamine and nor epinephrine are beneficial to improve microcirculation and tissue oxygen metabolism in the treatment of septic shock, and the clinical effect of nor epinephrine was distinctly better than dopamine.
authors.affiliation: ICU, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Du
authors.affiliation: ICU, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Lirui
authors.initials: L
authors.lastname: Wang
authors.affiliation: ICU, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Shi
authors.affiliation: ICU, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004298:Dopamine / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D004298:Dopamine; D009638:Norepinephrine