title: Herpes Simplex Virus Endotheliitis following Descemet's Membrane Endothelial Keratoplasty.
abstract: OBJECTIVE
  To report a case of herpes simplex virus (HSV) endotheliitis following simultaneous phacoemulsification, intraocular lens (IOL) implantation and descemet's membrane endothelial keratoplasty (DMEK).
  
  
  METHODS
  A;45 year-old female with corneal endothelial decompensation and a mature cataract, and history of anterior uveitis underwent simultaneous phacoemulsification, IOL implantation and DMEK. Increased corneal edema and descemet's membrane (DM) detachment occurred on postoperative day 3 and 5, respectively. One week after surgery, active keratic precipitates (KPs) appeared. Polymerase chain reaction (PCR) analysis was performed on an aqueous sample which was positive for herpes simplex virus (HSV). After initiating oral acyclovir and frequent topical corticosteroids, the corneal edema resolved and the donor tissue became spontaneously reattached to the recipient corneal stroma.
  
  
  CONCLUSIONS
  HSV endotheliitis may occur in the early postoperative period after DMEK and manifest as endothelial dysfunction leading to donor detachment. Anti-viral medication may help treat the acute phase and reduce the risk of recurrence.
authors.affiliation: Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Siamak
authors.initials: S
authors.lastname: Zarei-Ghanavati
authors.affiliation: Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Alizadeh
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA.
authors.forename: Sonia H
authors.initials: SH
authors.lastname: Yoo
keywords: Descemet's Membrane Endothelial Keratoplasty; Endotheliitis; Herpes Simplex Virus