title: ExoCarta: A Web-Based Compendium of Exosomal Cargo.
abstract: Exosomes are membranous vesicles that are released by a variety of cells into the extracellular microenvironment and are implicated in intercellular communication. As exosomes contain RNA, proteins and lipids, there is a significant interest in characterizing the molecular cargo of exosomes. Here, we describe ExoCarta (http://www.exocarta.org), a manually curated Web-based compendium of exosomal proteins, RNAs and lipids. Since its inception, the database has been highly accessed (>54,000 visitors from 135 countries). The current version of ExoCarta hosts 41,860 proteins, >7540 RNA and 1116 lipid molecules from more than 286 exosomal studies annotated with International Society for Extracellular Vesicles minimal experimental requirements for definition of extracellular vesicles. Besides, ExoCarta features dynamic protein-protein interaction networks and biological pathways of exosomal proteins. Users can download most often identified exosomal proteins based on the number of studies. The downloaded files can further be imported directly into FunRich (http://www.funrich.org) tool for additional functional enrichment and interaction network analysis.
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address: S.Keerthikumar@latrobe.edu.au.
authors.forename: Shivakumar
authors.initials: S
authors.lastname: Keerthikumar
authors.affiliation: Department of Computer Science and Information Technology, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Chisanga
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: Dinuka
authors.initials: D
authors.lastname: Ariyaratne
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: Haidar
authors.initials: H
authors.lastname: Al Saffar
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: Sushma
authors.initials: S
authors.lastname: Anand
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: Kening
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: Monisha
authors.initials: M
authors.lastname: Samuel
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: Mohashin
authors.initials: M
authors.lastname: Pathan
authors.affiliation: Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: Markandeya
authors.initials: M
authors.lastname: Jois
authors.affiliation: Department of Computer Science and Information Technology, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: Naveen
authors.initials: N
authors.lastname: Chilamkurti
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
authors.forename: Lahiru
authors.initials: L
authors.lastname: Gangoda
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address: S.Mathivanan@latrobe.edu.au.
authors.forename: Suresh
authors.initials: S
authors.lastname: Mathivanan
mesh_terms: D062126:Databases, Chemical; D055354:Exosomes / Q000737:chemistry* / Q000378:metabolism*; D020407:Internet; D008055:Lipids / Q000032:analysis*; D020543:Proteome / Q000032:analysis*; D012313:RNA / Q000032:analysis*
chemical_list: D008055:Lipids; D020543:Proteome; D012313:RNA
keywords: FunRich; exosomes; extracellular vesicles; protein–protein interactions