title: MALAT1 long non-coding RNA in cancer.
abstract: A recent massive parallel sequencing analysis has shown the fact that more than 80% of the human genome is transcribed into RNA. Among many kinds of the non-protein coding RNAs, we focus on the metastasis associated lung adenocarcinoma transcript 1 (MALAT1) that is a long non-coding RNA upregulated in metastatic carcinoma cells. Two molecular functions of MALAT1 have been proposed, one is the control of alternative splicing and the other is the transcriptional regulation. In this review, we document the molecular characteristics and functions of MALAT1 and shed light on the implication in the molecular pathology of various cancers. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.
authors.affiliation: Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Chemical Genetics Laboratory, RIKEN, Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address: ryoshi@fujita-hu.ac.jp.
authors.forename: Rei
authors.initials: R
authors.lastname: Yoshimoto
authors.affiliation: Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
authors.forename: Akila
authors.initials: A
authors.lastname: Mayeda
authors.affiliation: Chemical Genetics Laboratory, RIKEN, Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: RNA Biology Laboratory, RIKEN, Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakagawa
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D062085:RNA, Long Noncoding / Q000096:biosynthesis* / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: C557041:MALAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding
keywords: Cancer; MALAT1; Noncoding RNA; Splicing