title: Filoviruses: One of These Things is (not) Like the Other.
abstract: The family Filoviridae contains several of the most deadly pathogens known to date and the current Ebola virus disease (EVD) outbreak in Western Africa, due to Ebola virus (EBOV) infection, highlights the need for active and broad research into filovirus pathogenesis. However, in comparison, the seven other known filovirus family members are significantly understudied. Many of these, including Marburgviruses and Ebolaviruses other than EBOV, are also highly virulent and fully capable of causing widespread epidemics. This review places the focus on these non-EBOV filoviruses, including known immunological and pathological data. The available animal models, research tools and currently available therapeutics will also be discussed along with an emphasis in the large number of current gaps in knowledge of these less highlighted filoviruses. It is evident that much research is yet to be done in order to bring the non-EBOV filovirus field to the forefront of current research and, importantly, to the development of more effective vaccines and therapeutics to combat potential future outbreaks.
authors.affiliation: Immunology Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. scottmanthony@gmail.com.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Anthony
authors.affiliation: University of New Mexico, Center for Global Health, Department of Internal Medicine. sbradfute@salud.unm.edu.
authors.forename: Steven B
authors.initials: SB
authors.lastname: Bradfute
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends; D004195:Disease Models, Animal; D004196:Disease Outbreaks; D016563:Filoviridae / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D018702:Filoviridae Infections / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology / Q000821:virology*; D006801:Humans; D014774:Virulence
keywords: Ebola; Ebolavirus; Filoviridae; Marburg; Marburgvirus; animal models; correlates of immunity; filovirus; hemorrhagic