title: The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine.
abstract: A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions.
authors.affiliation: Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Roszkowski
authors.affiliation: National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland and ; National Centre for Nuclear Research, Andrzeja Sołtana 7, 05-400 Otwock-Świerk, Poland.
authors.forename: Jan K
authors.initials: JK
authors.lastname: Maurin
authors.affiliation: Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Czarnocki
keywords: chiral diamines; enantioselective reduction; epinastine; mianserin; ruthenium complexes