title: Enhanced depth imaging optical coherence tomography in adult-onset foveomacular vitelliform dystrophy.
abstract: OBJECTIVE
  To compare mean choroidal thickness in patients with adult-onset foveomacular vitelliform dystrophy (AOFVD) and healthy subjects, to analyze patients with AOFVD in order to evaluate choroidal thickness disease-related changes, also in relation to the different stages of AOFVD disease and to the retinal pigment epithelium (RPE) features, and to correlate mean choroidal thickness with age in both groups.
  
  
  METHODS
  In this prospective observational cross-sectional study, a total of 63 eyes of 51 consecutive subjects were examined, consisting of a control group (n = 28 eyes) and the AOFVD group (n = 35 eyes). A complete ophthalmologic examination, fundus autofluorescence, and spectral-domain optical coherence tomography were performed in all patients.
  
  
  RESULTS
  Mean subfoveal choroidal thickness was 214.78 ± 62.35 µm in healthy subjects and 222.31 ± 73.29 µm in the AOFVD group (p = 0.33). In the vitelliruptive group, the mean choroidal thickness was significantly thicker than in the control group at each choroidal location. Mean choroidal thickness was significantly increased in the pseudohypopyon stage when compared to the vitelliform one (+66.34 µm, p = 0.02). Eyes with subretinal fluid (SRF) showed significantly thicker choroid when compared with those without SRF. No significant correlations were found between age and choroidal thickness in the study group.
  
  
  CONCLUSIONS
  The study of the choroid in patients with AOFVD suggested a possible role in the pathologic changes during the different stages of disease, and could help us to evaluate progression of the disease. Greater choroidal thickness associated with SRF and RPE bumps are signs of RPE alterations and could be related to evolution of the AOFVD lesion to a different stage.
authors.affiliation: Department of Medical-Surgical Sciences and Biotechnologies, U.O.S.D. Ophthalmology, Sapienza University of Rome, Terracina (Latina) - Italy.
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Grenga
authors.affiliation: Department of Medical-Surgical Sciences and Biotechnologies, U.O.S.D. Ophthalmology, Sapienza University of Rome, Terracina (Latina) - Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Fragiotta
authors.affiliation: Department of Medical-Surgical Sciences and Biotechnologies, U.O.S.D. Ophthalmology, Sapienza University of Rome, Terracina (Latina) - Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cutini
authors.affiliation: Department of Surgical Specialties, Ophthalmology Clinic, University of Messina, Messina - Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Meduri
authors.affiliation: Department of Medical-Surgical Sciences and Biotechnologies, U.O.S.D. Ophthalmology, Sapienza University of Rome, Terracina (Latina) - Italy.
authors.forename: Enzo Maria
authors.initials: EM
authors.lastname: Vingolo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D058471:Subretinal Fluid; D041623:Tomography, Optical Coherence / Q000379:methods*; D057826:Vitelliform Macular Dystrophy / Q000175:diagnosis*