title: Caregiver treatment satisfaction is improved together with children's asthma control: Prospective study for budesonide monotherapy in school-aged children with uncontrolled asthma symptoms.
abstract: BACKGROUND
  If asthmatic children cannot obtain sufficient control of their disease, not only do they suffer from asthma symptoms, but the daily life activities of their caregivers are also disrupted. We investigated the effectiveness of an inhaled corticosteroid (ICS) for symptom control in previously ICS-untreated school-aged asthmatic children as well as caregiver treatment satisfaction (CTS).
  
  
  METHODS
  A multicenter, open-label, single-arm study on 12-week ICS (budesonide Turbuhaler®) monotherapy was undertaken in subjects aged 5-15 years with bronchial asthma not treated with ICS during the previous 3 months. At 0, 4, 8, and 12 weeks after start of ICS administration, Japanese Pediatric Asthma Control Program (JPAC) scores, and CTS scores were summated and lung function measured. At weeks 0 and 12, questionnaires on caregiver anxiety were also assessed.
  
  
  RESULTS
  Seventy-five patients were enrolled, and 69 assessed. Ninety percent of subjects had been treated with asthma controller medication except ICS before study enrollment. JPAC score and CTS score were improved significantly at weeks 4, 8, and 12 (p < 0.001). With regard to CTS, more than half of caregivers showed a perfect score at weeks 8 and 12. There was a significant correlation between JPAC score and CTS score. Lung function and caregiver anxiety were also improved, and good compliance with treatment was observed during the intervention.
  
  
  CONCLUSIONS
  If treating ICS-untreated school-aged asthmatic children with uncontrolled symptoms, ICS monotherapy can improve CTS along with improving asthma control.
authors.affiliation: Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan. Electronic address: shigemi@dokkyomed.ac.jp.
authors.forename: Shigemi
authors.initials: S
authors.lastname: Yoshihara
authors.affiliation: Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan; Department of Pediatrics, Nishikata Hospital, Tochigi, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Kanno
authors.affiliation: Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Fukuda
authors.affiliation: Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Arisaka
authors.affiliation: Arita Clinic of Pediatrics and Pediatric Allergy, Hiroshima, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Arita
authors.affiliation: Sekine Pediatric Clinic, Chiba, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Sekine
authors.affiliation: Department of Pediatrics, The Fraternity Memorial Hospital, Tokyo, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamaguchi
authors.affiliation: Tsuchida Kodomo Clinic, Kanagawa, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuchida
authors.affiliation: Yamada Gastrointestinal Internal Medicine and Pediatric Clinic, Tochigi, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: Watanabe Pediatric Allergy Clinic, Hokkaido, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Shimizu Pediatrics and Allergy Clinic, Saitama, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Nishikawa Clinic, Kagawa, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nishikawa
authors.affiliation: Department of Pediatrics, National Hospital Organization Shimoshizu National Hospital, Chiba, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nishimuta
mesh_terms: D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D019819:Budesonide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017028:Caregivers / Q000523:psychology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D017060:Patient Satisfaction; D010549:Personal Satisfaction; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D019819:Budesonide
keywords: Asthma symptoms; Budesonide monotherapy; Caregiver treatment satisfaction; JPAC; Pediatric asthma