title: Stage-related results in treatment of hip osteonecrosis with core-decompression and autologous mesenchymal stem cells.
abstract: Our aim is to analyse the clinical outcome of a series of patients affected by avascular necrosis of the femoral head and treated with core-decompression technique and autologous stromal cells of the bone marrow.We enrolled in our study 29 patients with 31 hips in total affected by avascular necrosis of the femoral head. The clinical and radiological outcome has been assessed through self-administered questionnaires (HHS, VAS and SF12) X-ray and Magnetic Resonance.Of all the examined hips, 25 showed a relief of the symptoms and a resolution of the osteonecrosis, 11 of these were at Stage I and 14 at Stage II. The progression of the disease occurred in 6 hips (2 Stage II, 2 Stage III and 2 Stage IV). Our results show a significant decrease in joint pain level and a success in avoiding or delaying the need of hip replacement in early stages of osteonecrosis.
authors.forename: Pietro
authors.initials: P
authors.lastname: Persiani
authors.forename: Claudia
authors.initials: C
authors.lastname: De Cristo
authors.forename: Jole
authors.initials: J
authors.lastname: Graci
authors.forename: Giovanni
authors.initials: G
authors.lastname: Noia
authors.forename: Michele
authors.initials: M
authors.lastname: Gurzì
authors.forename: Ciro
authors.initials: C
authors.lastname: Villani
mesh_terms: D000328:Adult; D019299:Decompression, Surgical / Q000379:methods*; D018450:Disease Progression; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome