title: Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer.
abstract: Continuous energy supply, a necessary condition for life, excites a state far from thermodynamic equilibrium, in particular coherent electric polar vibrations depending on water ordering in the cell. Disturbances in oxidative metabolism and coherence are a central issue in cancer development. Oxidative metabolism may be impaired by decreased pyruvate transfer to the mitochondrial matrix, either by parasitic consumption and/or mitochondrial dysfunction. This can in turn lead to disturbance in water molecules' ordering, diminished power, and coherence of the electromagnetic field. In tumors with the Warburg (reverse Warburg) effect, mitochondrial dysfunction affects cancer cells (fibroblasts associated with cancer cells), and the electromagnetic field generated by microtubules in cancer cells has low power (high power due to transport of energy-rich metabolites from fibroblasts), disturbed coherence, and a shifted frequency spectrum according to changed power. Therapeutic strategies restoring mitochondrial function may trigger apoptosis in treated cells; yet, before this step is performed, induction (inhibition) of pyruvate dehydrogenase kinases (phosphatases) may restore the cancer state. In tumor tissues with the reverse Warburg effect, Caveolin-1 levels should be restored and the transport of energy-rich metabolites interrupted to cancer cells. In both cancer phenotypes, achieving permanently reversed mitochondrial dysfunction with metabolic-modulating drugs may be an effective, specific anti-cancer strategy.
authors.affiliation: Institute of Photonics and Electronics, Czech Academy of Sciences, Chaberská 57, 182 51 Prague 8, Czech Republic. pokorny@ufe.cz.
authors.forename: Jiří
authors.initials: J
authors.lastname: Pokorný
authors.affiliation: Institute of Physics, Czech Academy of Sciences, Na Slovance 2, 182 21 Prague 8, Czech Republic. pokorny@fzu.cz.
authors.forename: Jan
authors.initials: J
authors.lastname: Pokorný
authors.affiliation: Institute of Translational Pharmacology, National Research Council-CNR, Via Fosso del Cavaliere 100, Rome 00133, Italy. contact@albertofoletti.ch.|Clinical Biophysics International Research Group, via Maggio 21, Lugano 6900, Switzerland. contact@albertofoletti.ch.
authors.forename: Alberto
authors.initials: A
authors.lastname: Foletti
authors.affiliation: Department of Obstetrics and Gynaecology, 1st Faculty of Medicine, Charles University in Prague, Apolinářská 18, 128 00 Prague 2, Czech Republic. jitka.kobilkova@centrum.cz.
authors.forename: Jitka
authors.initials: J
authors.lastname: Kobilková
authors.affiliation: Faculty of Electrical Engineering, Czech Technical University in Prague, Technická 2, 166 27 Prague 6, Czech Republic. vrba@fel.cvut.cz.
authors.forename: Jan
authors.initials: J
authors.lastname: Vrba
authors.affiliation: Faculty of Biomedical Engineering, Czech Technical University in Kladno, Sitná Square 3105, 272 01 Kladno, Czech Republic. jan.vrba@fbmi.cvut.cz.
authors.forename: Jan
authors.initials: J
authors.lastname: Vrba
keywords: LDH virus; cancer biophysics; disturbed coherence; microtubule oscillations; mitochondrial dysfunction; water ordering