title: A novel glycobiomarker, Wisteria floribunda agglutinin macrophage colony-stimulating factor receptor, for predicting carcinogenesis of liver cirrhosis.
abstract: Recently, we identified a novel liver fibrosis glycobiomarker, Wisteria floribunda agglutinin (WFA)-reactive colony stimulating factor 1 receptor (WFA(+) -CSF1R), using a glycoproteomics-based strategy. The aim of this study was to assess the value of measuring WFA(+) -CSF1R levels for the prognosis of carcinogenesis and outcome in liver cirrhosis (LC) patients with hepatitis C virus (HCV). WFA(+) -CSF1R and Total-CSF1R levels were measured in serum samples from 214 consecutive HCV-infected patients to evaluate their impact on carcinogenesis and the survival of LC patients. Serum WFA(+) -CSF1R levels were significantly higher in LC patients than chronic hepatitis (CH) patients (p < 0.001). The AUC of WFA(+) -CSF1R for predicting overall survival, calculated by time-dependent ROC analysis, was 0.691 and the HR (per 1-SD increase) was 1.80 (95% CI, 1.23-2.62, p < 0.001). Furthermore, the survival rate of LC patients with high WFA(+) -CSF1R levels (≥ 310 ng/ml) was significantly worse than those with lower levels (p < 0.01). The AUC of WFA(+) /total-CSF1R percentage (WFA(+) -CSF1R%) for predicting the cumulative carcinogenesis rate was 0.760, with an HR of 1.66 (95% CI 1.26-2.20, p < 0.001). In fact, the carcinogenesis rate was significantly higher in LC patients with a high WFA(+) -CSF1R% (≥ 35%, p = 0.006). Assessing serum levels of WFA(+) -CSF1R has diagnostic value for predicting carcinogenesis and the survival of LC patients.
authors.affiliation: Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.|Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Iio
authors.affiliation: Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ocho
authors.affiliation: Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Akira
authors.initials: A
authors.lastname: Togayachi
authors.affiliation: Division of Advanced Medicine Promotion, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Nojima
authors.affiliation: Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kuno
authors.affiliation: Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Ikehara
authors.affiliation: Department of Gastroenterology, Japan Community Health care Organization, Chukyo Hospital, Nagoya, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Hasegawa
authors.affiliation: Clinical Research Center, National Nagasaki Medical Center, Omura, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yatsuhashi
authors.affiliation: Clinical Research Center, National Nagasaki Medical Center, Omura, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yamasaki
authors.affiliation: Department of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Matsudo, Japan.
authors.forename: Noritomo
authors.initials: N
authors.lastname: Shimada
authors.affiliation: Division of Gastroenterology, Department of Medicine, Kurume University, Kurume, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ide
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Shinkai
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Shunske
authors.initials: S
authors.lastname: Nojiri
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Fujiwara
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Joh
authors.affiliation: The Research Center of Japan, Hepatitis and Immunology, Kohnodai Hospital, International Medical Center, Ichikawa, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizokami
authors.affiliation: Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Narimatsu
authors.affiliation: Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.|The Hepatitis Glyco-biomarker Study Group: https://unit.aist.go.jp/rcmg/hepatitis-pi/en/index_hptts_e.html.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D037121:Plant Lectins / Q000097:blood / Q000378:metabolism*; D012372:ROC Curve; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000097:blood / Q000378:metabolism*; D034781:Receptors, N-Acetylglucosamine / Q000097:blood / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D037121:Plant Lectins; D034781:Receptors, N-Acetylglucosamine; C040129:wisteria lectin; D016186:Receptor, Macrophage Colony-Stimulating Factor
keywords: Wisteria floribunda agglutinin-reactive colony-stimulating factor 1 receptor; hepatocellular carcinoma; liver fibrosis; prognosis; serum biomarker