title: Dual antiplatelet compared to triple antithrombotic therapy in anterior wall acute myocardial infarction complicated by depressed left ventricular ejection fraction.
abstract: Current guidelines recommend triple antithrombotic therapy (TT) consisting of warfarin, aspirin, and a P2Y12 inhibitor following an anterior ST elevation myocardial infarction (STEMI) complicated by extensive wall motion abnormalities. This recommendation, however, is based on data collected before percutaneous coronary intervention (PCI) became the standard of care for the treatment of STEMI. We designed a retrospective study of patients who received PCI for anterior STEMI over an 8-year period to compare rates of thromboembolic and bleeding events between patients receiving dual antiplatelet therapy (DAPT) and those receiving TT, including warfarin. Patients were included if the predischarge echocardiogram showed extensive wall motion abnormality and an ejection fraction ≤35%. Patients with known left ventricular thrombus were excluded. A total of 124 patients met the criteria, with 80 patients in the DAPT group and 44 in the TT group. The median age was 58 years in the TT group and 64 years in the DAPT group (P < 0.04), with an average ejection fraction of 31%. Thromboembolic events occurred in 4 patients (5%) in the DAPT group compared with 3 patients (6.8%) in the TT group (P = 0.70). Bleeding occurred in 2 patients in the DAPT group and 4 patients in the TT group (2.5% in DAPT vs. 9.1% in TT group, P = 0.18). No differences in rates of clinical embolism or left ventricular thrombus were found. Our data support recent findings that warfarin may not be indicated for patients following PCI for anterior STEMI, even when significant wall motion abnormalities and reduced ejection fraction ≤35% are present.
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health Science Center, and Baylor Scott & White Health, Temple, Texas.
authors.forename: Ola O
authors.initials: OO
authors.lastname: Oyetayo
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health Science Center, and Baylor Scott & White Health, Temple, Texas.
authors.forename: Kipp
authors.initials: K
authors.lastname: Slicker
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health Science Center, and Baylor Scott & White Health, Temple, Texas.
authors.forename: Lisa
authors.initials: L
authors.lastname: De La Rosa
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health Science Center, and Baylor Scott & White Health, Temple, Texas.
authors.forename: Wesley
authors.initials: W
authors.lastname: Lane
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health Science Center, and Baylor Scott & White Health, Temple, Texas.
authors.forename: Dane
authors.initials: D
authors.lastname: Langsjoen
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health Science Center, and Baylor Scott & White Health, Temple, Texas.
authors.forename: Chhaya
authors.initials: C
authors.lastname: Patel
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health Science Center, and Baylor Scott & White Health, Temple, Texas.
authors.forename: Kevin
authors.initials: K
authors.lastname: Brough
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health Science Center, and Baylor Scott & White Health, Temple, Texas.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Michel
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Texas A&M Health Science Center and Baylor Scott & White Health, Temple, Texas (Oyetayo); the Division of Cardiology (Slicker, De La Rosa, Michel, Chiles) and Department of Internal Medicine (Lane, Langsjoen, Patel, Brough), College of Medicine, Texas A&M Health Science Center, and Baylor Scott & White Health, Temple, Texas.
authors.forename: Christopher
authors.initials: C
authors.lastname: Chiles