title: The relationship between perioperative administration of inhaled corticosteroid and postoperative respiratory complications after pulmonary resection for non-small-cell lung cancer in patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  Inhaled corticosteroid (ICS) treatment has been shown to increase the risk of respiratory complications in patients with stable chronic obstructive pulmonary disease (COPD). However, the effects of perioperative ICS treatment on postoperative respiratory complications after lung cancer surgery have not been elucidated. The aim of this study was to investigate whether perioperative ICS treatment would increase the risk of postoperative respiratory complications after lung cancer surgery in patients with COPD.
  
  
  METHODS
  We retrospectively analyzed 174 consecutive COPD patients with non-small-cell lung cancer (NSCLC) who underwent lobectomy or segmentectomy between January 2007 and December 2014. Subjects were grouped based on whether or not they were administered perioperative ICS treatment. Postoperative cardiopulmonary complications were compared between the groups.
  
  
  RESULTS
  There were no statistically significant differences in the incidence of postoperative respiratory complications (P = 0.573) between the perioperative ICS treatment group (n = 16) and the control group (n = 158). Perioperative ICS treatment was not significantly associated with postoperative respiratory complications in the univariate or multivariate analysis (odds ratio [OR] = 0.553, 95% confidence interval [CI] = 0.069-4.452, P = 0.578; OR = 0.635, 95% CI = 0.065-6.158, P = 0.695, respectively). Kaplan-Meier analysis showed that there were no statistically significant differences in the postoperative respiratory complications-free durations between the groups (P = 0.566), even after propensity score matching (P = 0.551).
  
  
  CONCLUSIONS
  There was no relationship between perioperative ICS administration and the incidences of postoperative respiratory complications after surgical resection for NSCLC in COPD patients.
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Yamanashi
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan. marumo@kuhp.kyoto-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Marumo
authors.affiliation: Department of Thoracic Surgery, Japanese Red Cross Otsu Hospital, Shiga, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shoji
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Fukui
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Sumitomo
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Otake
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Sakuramoto
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Motonari
authors.initials: M
authors.lastname: Fukui
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Cheng-Long
authors.initials: CL
authors.lastname: Huang
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000601:surgery*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology*; D008175:Lung Neoplasms / Q000150:complications / Q000601:surgery*; D008297:Male; D019990:Perioperative Care / Q000379:methods; D011013:Pneumonectomy; D011014:Pneumonia / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology*; D001261:Pulmonary Atelectasis / Q000453:epidemiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy*; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000453:epidemiology; D012131:Respiratory Insufficiency / Q000453:epidemiology / Q000628:therapy; D020775:Thoracic Surgery, Video-Assisted; D014139:Tracheostomy
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Inhaled corticosteroid; Lung cancer surgery; Postoperative respiratory complications