title: Gene-Diet Interactions in Age-Related Macular Degeneration.
abstract: Age-related macular degeneration (AMD) is a prevalent blinding disease, accounting for roughly 50 % of blindness in developed nations. Very significant advances have been made in terms of discovering genetic susceptibilities to AMD as well as dietary risk factors. To date, nutritional supplementation is the only available treatment option for the dry form of the disease known to slow progression of AMD. Despite an excellent understanding of genes and nutrition in AMD, there is remarkably little known about gene-diet interactions that may identify efficacious approaches to treat individuals. This review will summarize our current understanding of gene-diet interactions in AMD with a focus on animal models and human epidemiological studies.
authors.affiliation: USDA-JM Human Nutrition Research Center on Aging (HNRCA), Tufts University, 02111, Boston, MA, USA. Sheldon.rowan@tufts.edu.|Department of Ophthalmology, Tufts University School of Medicine, 02111, Boston, MA, USA. Sheldon.rowan@tufts.edu.
authors.forename: Sheldon
authors.initials: S
authors.lastname: Rowan
authors.affiliation: USDA-JM Human Nutrition Research Center on Aging (HNRCA), Tufts University, 02111, Boston, MA, USA. Allen.taylor@tufts.edu.|Department of Ophthalmology, Tufts University School of Medicine, 02111, Boston, MA, USA. Allen.taylor@tufts.edu.|Friedman School of Nutrition Science and Policy, Tufts University, 02111, Boston, MA, USA. Allen.taylor@tufts.edu.
authors.forename: Allen
authors.initials: A
authors.lastname: Taylor
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D004195:Disease Models, Animal; D018450:Disease Progression; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008268:Macular Degeneration / Q000178:diet therapy* / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors
keywords: ARMS2; Age-related macular degeneration; CFH; Gene-diet interaction; Genetic susceptibility; Glycemic index; High fat diet; Knockout mice; Nutrition; Retinal pigmented epithelium