title: Application of response surface methodology to optimise supercritical carbon dioxide extraction of essential oil from Cyperus rotundus Linn.
abstract: Supercritical fluid extraction with carbon dioxide (SC-CO2 extraction) was performed to isolate essential oils from the rhizomes of Cyperus rotundus Linn. Effects of temperature, pressure, extraction time, and CO2 flow rate on the yield of essential oils were investigated by response surface methodology (RSM). The oil yield was represented by a second-order polynomial model using central composite rotatable design (CCRD). The oil yield increased significantly with pressure (p<0.0001) and CO2 flow rate (p<0.01). The maximum oil yield from the response surface equation was predicted to be 1.82% using an extraction temperature of 37.6°C, pressure of 294.4bar, extraction time of 119.8 min, and CO2 flow rate of 20.9L/h.
authors.affiliation: School of Chemistry & Chemical Engineering, Zhaoqing University, Zhaoqing 526061, People's Republic of China. Electronic address: hwwangcn@hotmail.com.
authors.forename: Hongwu
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Chemistry & Chemical Engineering, Zhaoqing University, Zhaoqing 526061, People's Republic of China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Chemistry & Chemical Engineering, Zhaoqing University, Zhaoqing 526061, People's Republic of China.
authors.forename: Shoulian
authors.initials: S
authors.lastname: Wei
authors.affiliation: School of Chemistry & Chemical Engineering, Zhaoqing University, Zhaoqing 526061, People's Republic of China.
authors.forename: Zijun
authors.initials: Z
authors.lastname: Yan
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry*; D029786:Cyperus / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D009822:Oils, Volatile; D010936:Plant Extracts; D002245:Carbon Dioxide
keywords: Cyperus rotundus Linn.; Essential oil; Optimisation; Response surface methodology; Supercritical carbon dioxide