title: Transducer-like Enhancer of Split 1 as a Novel Immuno- histochemical Marker for Diagnosis of Synovial Sarcoma.
abstract: BACKGROUND
  Synovial sarcoma is a mesenchymal neoplasm that accounts for around 10% of all soft tissue sarcomas. The diagnosis of synovial sarcoma can be a challenging task, particularly with small biopsy specimens.
  
  
  OBJECTIVE
  We investigated transducer-like enhancer of split 1 (TLE1), monoclonal antibody, expression by immunohistochemical analysis in a group of 74 synovial sarcoma cases, 20 cases of MPNST, 12 cases of neurofibroma, 15 cases of schwannoma, 5 cases of MFH, 10 cases of lieomyosarcoma and 10 cases of solitary fibrous tumor.
  
  
  METHODS
  Whole tissue sections were examined: (39 biphasic and 35 monophasic). Nuclear immunoreactivity was scored as negative (<5% of cells positive), 1+(mild /5-25%), 2+ (moderate/25-50%), and 3+ (strong >50%).
  
  
  RESULTS
  Overall, 71 (96%) of 74 synovial sarcomas were positive for TLE1, including 37 biphasic (95%) and 34 monophasic (97%) tumors. Other spindle cell tumors showed very low or absent staining of TLE1.
  
  
  CONCLUSIONS
  We conclude that TLE1 is a sensitive marker and can be a useful diagnostic marker for synovial sarcoma, particularly the monophasic forms.
authors.affiliation: Pathology Department,Faculty of Medicine, Tanta University, Egypt E-mail : dr-aliaaatef@hotmail.com.
authors.forename: Aliaa
authors.initials: A
authors.lastname: Atef
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alrashidy
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D056970:Co-Repressor Proteins; D051677:Histiocytoma, Malignant Fibrous / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000737:chemistry*; D009442:Neurilemmoma / Q000737:chemistry*; D009455:Neurofibroma / Q000737:chemistry*; D012097:Repressor Proteins / Q000032:analysis*; D013584:Sarcoma, Synovial / Q000737:chemistry* / Q000175:diagnosis* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000737:chemistry* / Q000175:diagnosis* / Q000473:pathology; D054364:Solitary Fibrous Tumors / Q000737:chemistry*
chemical_list: D014408:Biomarkers, Tumor; D056970:Co-Repressor Proteins; D012097:Repressor Proteins; C499043:TLE1 protein, human