title: Long Non-Coding RNAs as Master Regulators in Cardiovascular Diseases.
abstract: Cardiovascular disease is the leading cause of death in the United States, accounting for nearly one in every seven deaths. Over the last decade, various targeted therapeutics have been introduced, but there has been no corresponding improvement in patient survival. Since the mortality rate of cardiovascular disease has not been significantly decreased, efforts have been made to understand the link between heart disease and novel therapeutic targets such as non-coding RNAs. Among multiple non-coding RNAs, long non-coding RNA (lncRNA) has emerged as a novel therapeutic in cardiovascular medicine. LncRNAs are endogenous RNAs that contain over 200 nucleotides and regulate gene expression. Recent studies suggest critical roles of lncRNAs in modulating the initiation and progression of cardiovascular diseases. For example, aberrant lncRNA expression has been associated with the pathogenesis of ischemic heart failure. In this article, we present a synopsis of recent discoveries that link the roles and molecular interactions of lncRNAs to cardiovascular diseases. Moreover, we describe the prevalence of circulating lncRNAs and assess their potential utilities as biomarkers for diagnosis and prognosis of heart disease.
authors.affiliation: Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. karcher@gru.edu.
authors.forename: Krystal
authors.initials: K
authors.lastname: Archer
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. zbroskova@gru.edu.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Broskova
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. abayoumi@gru.edu.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Bayoumi
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. jteoh@gru.edu.
authors.forename: Jian-peng
authors.initials: JP
authors.lastname: Teoh
authors.affiliation: Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. adavila@gru.edu.
authors.forename: Alec
authors.initials: A
authors.lastname: Davila
authors.affiliation: Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. yaotang@gru.edu.|Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. yaotang@gru.edu.
authors.forename: Yaoliang
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. hsu@gru.edu.
authors.forename: Huabo
authors.initials: H
authors.lastname: Su
authors.affiliation: Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. ilkim@gru.edu.|Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. ilkim@gru.edu.
authors.forename: Il-man
authors.initials: IM
authors.lastname: Kim
mesh_terms: D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D005786:Gene Expression Regulation; D006801:Humans; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D015415:Biomarkers; D062085:RNA, Long Noncoding
keywords: chromatin; epigenetic regulation; gene regulation; heart disease; non-coding RNAs