title: [Induced differentiation of stem cells into androgen-secreting cells].
abstract: Leydig cells are the major source of androgens in males. Stem cells can be induced to differentiate into androgen-secreting Leydig like cells, whose functions are regulated by the hypothalamus and pituitary, so that they precisely secret the necessary hormones to maintain physiological function. Therefore, the establishment of an effective protocol to induce the differentiation of stem cells into androgen-secreting cells is very helpful for the treatment of hypogonadism caused by abnormalities of Leydig cells. This review outlines the recent findings concerning the differentiation of stem cells into androgen-secreting cells.
authors.forename: Zhi-yuan
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
mesh_terms: D000728:Androgens / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D007006:Hypogonadism / Q000628:therapy; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D010902:Pituitary Gland / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*
chemical_list: D000728:Androgens