title: Role of the nucleolus in neurodegenerative diseases with particular reference to the retina: a review.
abstract: The nucleolus has emerged as a key regulator of cellular growth and the response to stress, in addition to its traditionally understood function in ribosome biogenesis. The association between nucleolar function and neurodegenerative disease is increasingly being explored. There is also recent evidence indicating that the nucleolus may well be crucial in the development of the eye. In this present review, the role of the nucleolus in retinal development as well as in neurodegeneration with an emphasis on the retina is discussed.
authors.affiliation: Ophthalmic Research Laboratories, Royal Adelaide Hospital, Adelaide, South Australia, Australia.|Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Paul I
authors.initials: PI
authors.lastname: Sia
authors.affiliation: Ophthalmic Research Laboratories, Royal Adelaide Hospital, Adelaide, South Australia, Australia.|Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: John Pm
authors.initials: JP
authors.lastname: Wood
authors.affiliation: Ophthalmic Research Laboratories, Royal Adelaide Hospital, Adelaide, South Australia, Australia.|Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Glyn
authors.initials: G
authors.lastname: Chidlow
authors.affiliation: Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
authors.forename: Shiwani
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
authors.forename: Jamie
authors.initials: J
authors.lastname: Craig
authors.affiliation: Ophthalmic Research Laboratories, Royal Adelaide Hospital, Adelaide, South Australia, Australia.|Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Casson
mesh_terms: D002466:Cell Nucleolus / Q000502:physiology*; D049109:Cell Proliferation / Q000502:physiology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D012160:Retina / Q000254:growth & development*; D012162:Retinal Degeneration / Q000503:physiopathology*
keywords: glaucoma; neurodegeneration; nucleolar stress; nucleolus; retinal development