title: SIRT1 and insulin resistance.
abstract: Sirtuin 1 (SIRT1) is a prototype mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. Growing evidence suggests that SIRT1 regulates glucose and lipid metabolism through its deacetylase activity. In this review, we have summarized the recent progress in SIRT1 research with a particular focus on the role of SIRT1 in insulin resistance at different metabolic tissues. Recent data indicate that activated SIRT1 improves the insulin sensitivity of liver, skeletal muscle and adipose tissues and protects the function and cell mass of pancreatic β-cells. These findings suggest that SIRT1 might be a new therapeutic target for the prevention of disease related to insulin resistance, such as metabolic syndrome and type 2 diabetes mellitus.
authors.affiliation: Department of Endocrinology, the 3rd Hospital of Hebei Medical University, Ziqiang Road 139, Shijiazhuang, Hebei Province, China, 050051.
authors.forename: Yue
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Ophthalmology, the 3rd Hospital of Hebei Medical University, Ziqiang Road 139, Shijiazhuang, Hebei Province, China, 050051.
authors.forename: Xinli
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Physiology; Hebei Medical University, Zhongshan Road 361, Shijiazhuang, Hebei Province, China, 050017.
authors.forename: Huijie
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Internal Neurology, the 3rd Hospital of Hebei Medical University, Ziqiang Road 139, Shijiazhuang, Hebei Province, China, 050051.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, the 3rd Hospital of Hebei Medical University, Ziqiang Road 139, Shijiazhuang, Hebei Province, China, 050051.
authors.forename: Peng
authors.initials: P
authors.lastname: Xue
authors.affiliation: Department of Endocrinology, the 3rd Hospital of Hebei Medical University, Ziqiang Road 139, Shijiazhuang, Hebei Province, China, 050051. Electronic address: liuyanjiangcn@hotmail.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D004789:Enzyme Activation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008958:Models, Molecular; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism*; D056564:Sirtuin 1 / Q000737:chemistry / Q000378:metabolism*
chemical_list: D007328:Insulin; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D005947:Glucose
keywords: Insulin resistance; Organ; Sirtuins; Tissue; Type 2 diabetes mellitus