title: Addition of lipids to parenteral nutrition does not cause fungal infections.
abstract: Parenteral nutrition (PN) that includes lipid emulsion is considered to increase both bacterial and fungal central venous catheter-related bloodstream infections. This concept is based on several erroneous metrics: Reports in age-old literature at a time when preparing PN admixtures lacked stringent quality control, when its infusion, the techniques of insertion, maintenance of vascular access devices, and delivery systems were not well identified or enforced. Additionally, concepts of glucohomeostasis were different and higher glucose levels were accepted. We provide updated information with supporting literature to show that associating PN with lipids with an increase in bloodstream infections is not justified.
authors.affiliation: Division of Surgical Critical Care, Department of Surgery, Stroger Hospital of Cook County, Oak Park, IL, USA. Electronic address: ksriram41@hotmail.com.
authors.forename: Krishnan
authors.initials: K
authors.lastname: Sriram
authors.affiliation: Department of Surgery, Upstate Medical University, University Hospital, Syracuse, NY, USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Meguid
mesh_terms: D055499:Catheter-Related Infections / Q000209:etiology* / Q000382:microbiology; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects; D005658:Fungi; D006801:Humans; D008055:Lipids / Q000008:administration & dosage* / Q000009:adverse effects; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000379:methods
chemical_list: D005217:Fat Emulsions, Intravenous; D008055:Lipids
keywords: Bloodstream infections; Candidemia; Fungal infections; Lipid emulsions; Lipids; Parenteral nutrition