title: Sex commonalities and differences in the relationship between resilient personality and the intrinsic connectivity of the salience and default mode networks.
abstract: Increased resilience is associated with better health outcomes and reduced morbidity in response to injury and homeostatic perturbations. Proper functioning of the salience network (SN) and modulation of the default mode network (DMN) by SN may play a role in adaptively responding to stress. Here, we demonstrate that resilient personality in healthy subjects is associated with SN and DMN connectivity patterns and that these patterns are influenced by sex. While connectivity of SN with several brain regions including right anterior insula was significantly associated with resilient personality in both men and women, results suggest that increased functional integration of anterior DMN preferentially benefits women while increased functional integration of posterior DMN preferentially benefits men in terms of resilience. These findings may relate to previous demonstrations that men and women engage different information processing and behavioral strategies to achieve resilience and highlight the importance of considering sex in resilience research.
authors.affiliation: Oppenheimer Family Center for Neurobiology of Stress, UCLA, Los Angeles, CA, United States; Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States; Pain and Interoception Network (PAIN), UCLA, Los Angeles, CA, United States. Electronic address: lisa@lisakilpatrick.com.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Kilpatrick
authors.affiliation: Oppenheimer Family Center for Neurobiology of Stress, UCLA, Los Angeles, CA, United States.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Istrin
authors.affiliation: Oppenheimer Family Center for Neurobiology of Stress, UCLA, Los Angeles, CA, United States; Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States.
authors.forename: Arpana
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Oppenheimer Family Center for Neurobiology of Stress, UCLA, Los Angeles, CA, United States; Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States; Department of Psychiatry, UCLA, Los Angeles, CA, United States; Department of Physiology, UCLA, Los Angeles, CA, United States; Pain and Interoception Network (PAIN), UCLA, Los Angeles, CA, United States.
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Naliboff
authors.affiliation: Oppenheimer Family Center for Neurobiology of Stress, UCLA, Los Angeles, CA, United States; Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States; Department of Psychiatry, UCLA, Los Angeles, CA, United States; Department of Physiology, UCLA, Los Angeles, CA, United States; Pain and Interoception Network (PAIN), UCLA, Los Angeles, CA, United States; VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Tillisch
authors.affiliation: Oppenheimer Family Center for Neurobiology of Stress, UCLA, Los Angeles, CA, United States; Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States; Department of Psychiatry, UCLA, Los Angeles, CA, United States; Department of Physiology, UCLA, Los Angeles, CA, United States; Pain and Interoception Network (PAIN), UCLA, Los Angeles, CA, United States.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Labus
authors.affiliation: Oppenheimer Family Center for Neurobiology of Stress, UCLA, Los Angeles, CA, United States; Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States; Department of Psychiatry, UCLA, Los Angeles, CA, United States; Department of Physiology, UCLA, Los Angeles, CA, United States; Pain and Interoception Network (PAIN), UCLA, Los Angeles, CA, United States.
authors.forename: Emeran A
authors.initials: EA
authors.lastname: Mayer
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology*; D010551:Personality / Q000502:physiology*; D055500:Resilience, Psychological; D012727:Sex Characteristics; D055815:Young Adult
keywords: Default mode network; NEO personality inventory; Resilience; Resting state networks; Salience network; Sex differences