title: A triad of linezolid toxicity: hypoglycemia, lactic acidosis, and acute pancreatitis.
abstract: We present a case of suspected linezolid toxicity in a 34-year-old man with sickle cell disease and line-related vancomycin-resistant enterococcal bacteremia and tricuspid valve endocarditis. The patient developed sudden-onset hypoglycemia, lactic acidosis, and acute pancreatitis 11 days after initiation of linezolid. All adverse effects quickly resolved with drug cessation. The pathophysiology underlying this triad of linezolid toxicity is unclear, but may be related to mitochondrial dysfunction.
authors.affiliation: Department of Medicine (Johnson, Vaduganathan), Department of Pharmacy (Phillips), and Department of Pulmonary and Critical Care Medicine (O'Donnell), Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: P Connor
authors.initials: PC
authors.lastname: Johnson
authors.affiliation: Department of Medicine (Johnson, Vaduganathan), Department of Pharmacy (Phillips), and Department of Pulmonary and Critical Care Medicine (O'Donnell), Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Muthiah
authors.initials: M
authors.lastname: Vaduganathan
authors.affiliation: Department of Medicine (Johnson, Vaduganathan), Department of Pharmacy (Phillips), and Department of Pulmonary and Critical Care Medicine (O'Donnell), Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Kristy M
authors.initials: KM
authors.lastname: Phillips
authors.affiliation: Department of Medicine (Johnson, Vaduganathan), Department of Pharmacy (Phillips), and Department of Pulmonary and Critical Care Medicine (O'Donnell), Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Walter J
authors.initials: WJ
authors.lastname: O'Donnell