title: IgA nephropathy in Brazil: apropos of 600 cases.
abstract: IgA nephropathy (IgAN) is th e commonest primary glomerular disease worldwide. Studies on its prevalence in Brazil are however scarce. Databases and clinical records from 10 reference centres were retrospectively reviewed. Clinical and laboratory features at the moment of the biopsy were retrieved (age, gender, presence of hematuria, serum creatinine [mg/dL], proteinuria [g/24 h]). Renal biopsy findings were classified according to Haas single grade classification scheme and the Oxford Classification of IgAN. 600 cases of IgAN were identified, of which 568 (94.7 %) were on native kidneys. Male to female ratio was 1.24:1. Patients averaged 32.76 ± 15.12 years old (range 4-89, median 32). Proteinuria and hematuria were observed, respectively in 56.63 and 72.29 % of patients. The association of both these findings occurred in 37.95 % of the cases. Serum creatinine averaged 1.65 ± 0.67 mg/dL (median 1.5 mg/dL) at diagnosis. Segmental sclerosis and mesangial hypercellularity were the main glomerular findings (47.6 and 46.2 %) The commonest combination by Oxford Classification of IgAN, was M0 E0 S0 T0 (22.4 %). Chronic tubulo-interstitial lesions with an extension wider than 25 % of the renal cortex could be identified in 32.2 % of the cases. Tubular atrophy and interstitial fibrosis were more strongly associated with higher 24-h proteinuria and serum creatinine levels. Segmental sclerosis (S1) showed a stronger tendency of association with the presence of tubulo-interstitial lesions (T1 and T2) than other glomerular variables. To the best of our knowledge this is the largest series of IgAN in Brazil. It depicts the main biopsy findings and their possible clinical correlates. Our set of data is comparable to previous reports.
authors.affiliation: Department of Pathology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil ; Department of Medical Pathology, Federal University of Paraná (UFPR), Curitiba, Brazil ; Brazilian Kidney Club, Brazilian Society of Pathology (SBP), São Paulo, Brazil ; Departamento de Patologia Médica, Rua Padre Camargo, 280, 6. andar, Curitiba, PR 80060-240 Brazil.
authors.forename: Maria Fernanda
authors.initials: MF
authors.lastname: Soares
authors.affiliation: Department of Pathology, Federal Fluminense University (UFF), Niterói, Brazil ; Brazilian Kidney Club, Brazilian Society of Pathology (SBP), São Paulo, Brazil.
authors.forename: M L R
authors.initials: ML
authors.lastname: Caldas
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Oswaldo Cruz Foundation (CPqGM-FIOCRUZ), Salvador, Brazil ; Brazilian Kidney Club, Brazilian Society of Pathology (SBP), São Paulo, Brazil.
authors.forename: W L C
authors.initials: WL
authors.lastname: Dos-Santos
authors.affiliation: Santos Metropolitan University (UNIMES) and Ana Costa Hospital, Santos, Brazil ; Brazilian Kidney Club, Brazilian Society of Pathology (SBP), São Paulo, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Sementilli
authors.affiliation: Department of Pathology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil ; Brazilian Kidney Club, Brazilian Society of Pathology (SBP), São Paulo, Brazil.
authors.forename: P
authors.initials: P
authors.lastname: Furtado
authors.affiliation: Clinics Hospital, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil ; Federal University of Ouro Preto (UFOP), Ouro Prêto, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Araújo
authors.affiliation: Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil ; Brazilian Kidney Club, Brazilian Society of Pathology (SBP), São Paulo, Brazil.
authors.forename: K L
authors.initials: KL
authors.lastname: Pegas
authors.affiliation: Division of Health Sciences, Federal University of Parana (UFPR), Curitiba, Brazil.
authors.forename: R R
authors.initials: RR
authors.lastname: Petterle
authors.affiliation: Department of Pathology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil ; Brazilian Kidney Club, Brazilian Society of Pathology (SBP), São Paulo, Brazil.
authors.forename: M F
authors.initials: MF
authors.lastname: Franco
keywords: Berger’s disease; Epidemiology; IgA nephropathy; Pathology