title: Stable Tricyclic Antitubercular Ozonides Derived from Artemisinin.
abstract: New, highly stable tricyclic antitubercular ozonides 9 and 10 derived from artemisinin are reported in 39 and 9% yields, respectively. The ozonide groups of 9 and 10 were found to be stable under strong basic and acidic conditions. The absolute configuration of ozonides 9 was confirmed by X-ray crystallography. Ozonide 10 shows promising antitubercular activity against M. tuberculosis H37Ra and M. tuberculosis H37Rv with MIC values of 0.39 and 3.12 μg/mL, respectively.
authors.affiliation: Department of Chemistry & Materials Research Centre, Malaviya National Institute of Technology , Jawaharlal Nehru Marg, Jaipur 302017, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Chaudhary
authors.affiliation: Department of Chemistry & Materials Research Centre, Malaviya National Institute of Technology , Jawaharlal Nehru Marg, Jaipur 302017, India.
authors.forename: Vashundhra
authors.initials: V
authors.lastname: Sharma
authors.affiliation: Department of Chemistry & Materials Research Centre, Malaviya National Institute of Technology , Jawaharlal Nehru Marg, Jaipur 302017, India.
authors.forename: Pradeep K
authors.initials: PK
authors.lastname: Jaiswal
authors.forename: Anil N
authors.initials: AN
authors.lastname: Gaikwad
authors.forename: Sudhir K
authors.initials: SK
authors.lastname: Sinha
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Puri
authors.forename: Ashoke
authors.initials: A
authors.lastname: Sharon
authors.forename: Prakas R
authors.initials: PR
authors.lastname: Maulik
authors.forename: Vinita
authors.initials: V
authors.lastname: Chaturvedi
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D037621:Artemisinins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
chemical_list: C503429:1,2,4-trioxane; D000962:Antimalarials; D000995:Antitubercular Agents; D037621:Artemisinins; D006571:Heterocyclic Compounds; C031327:artemisinin