title: Magnetic Resonance Imaging of the Atherosclerotic Mouse Aorta.
abstract: Plaque development has been extensively studied using magnetic resonance imaging (MRI) in animal models of rapidly progressing atherosclerosis, such as apolipoprotein E-knockout (apoE-KO) mice. Preclinical MRI plays a significant role in the study of experimental atherosclerosis. Currently, MRI is capable of detecting luminal narrowing, plaque size, and morphology with high accuracy and reproducibility, providing reliable measurements of plaque burden. Therefore, MRI offers a noninvasive approach to serially monitor the progression of the disease. Compared with other imaging modalities, MRI appears to have the greatest potential for plaque characterization, through the use of multiple contrast weightings (e.g., T1, T2, and proton density). Here, we illustrate a standard procedure to image the aorta of atherosclerotic mice using noninvasive MRI.
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. jmateo@cnic.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Mateo
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.|CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Benito
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
authors.forename: Samuel
authors.initials: S
authors.lastname: España
authors.affiliation: The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine, New York, NY, USA.
authors.forename: Javier
authors.initials: J
authors.lastname: Sanz
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.|Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Jiménez-Borreguero
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.|The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine, New York, NY, USA.
authors.forename: Valentín
authors.initials: V
authors.lastname: Fuster
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.|CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.|Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Ruiz-Cabello
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000473:pathology*; D001018:Aortic Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D001706:Biopsy; D004195:Disease Models, Animal; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D018345:Mice, Knockout; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D015203:Reproducibility of Results
chemical_list: D001057:Apolipoproteins E
keywords: Aorta; Atherosclerosis; Magnetic resonance imaging (MRI); Plaque; apoE-KO mice