title: Correlation between polymorphisms in the IL-17A and IL-17F genes and development of coronary artery disease.
abstract: A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People's Hospital between May 2012 and May 2014. The IL-17A rs2275913 and IL-17F rs763780 genes were genotyped by polymerase chain reaction combined with a restriction fragment length polymorphism (PCR-RFLP). Logistic regression analysis revealed that individuals with the AA genotype of rs2275913 were associated with increased risk of CAD, compared to those with the GG genotype in a codominant model [adjusted odds ratio (OR) = 1.96; 95% confidence interval (CI) = 1.10-3.53]. On the other hand, the AA genotype of rs2275913 was correlated with moderately increased risk of CAD compared to the GG + GA genotype (adjusted OR = 1.76; 95%CI = 1.02-3.07) in a recessive model. However, no significant differences were observed between polymorphisms at the IL-17F rs763780 locus and CAD risk, in codominant, dominant, and recessive models. In conclusion, the results of our study suggested that the IL-17A rs2275913 polymorphism may affect the development of CAD; however, no significant association was observed between the IL-17F rs763780 polymorphism and risk of CAD.
authors.affiliation: Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: G Y
authors.initials: GY
authors.lastname: Geng
authors.affiliation: Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: H L
authors.initials: HL
authors.lastname: Liu
authors.affiliation: Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Mao
authors.affiliation: Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: N
authors.initials: N
authors.lastname: Ba
mesh_terms: D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D003710:Demography; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17