title: [Adherence to oral 5-aminosalicylic acid by patients with quiescent ulcerative colitis: a questionnaire survey].
abstract: For patients with ulcerative colitis, adherence to 5-aminosalicylic acid (5-ASA) is generally expected to ensure better maintenance of remission. Over the past 2 years, we have conducted a questionnaire survey in our hospital of 120 outpatients with quiescent ulcerative colitis to assess their adherence to oral 5-ASA. Of them, 112 patients responded. The overall adherence rate was 57%; however, the adherence rate for 5-ASA taken once a day was 95%, which was significantly higher than that for 5-ASA taken twice or three times a day (50%; P=0.00044). Univariate analysis revealed that the factors associated with high adherence included the following: type of 5-ASA derivative, intake of fewer drugs being at a time, and once-daily intake of 5-ASA. However, once-daily intake of 5-ASA was the only factor found to have a statistically significant effect using multivariate analysis. The adherence rate improved from 23% to 100% when the prescription for 5-ASA was changed from two or three times daily to once daily (P=0.000054).
authors.affiliation: Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kato
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Kani
authors.forename: Taisuke
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Yamamoto
authors.forename: Sumiko
authors.initials: S
authors.lastname: Nagoshi
authors.forename: Koji
authors.initials: K
authors.lastname: Yakabi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D012074:Remission Induction; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine