title: Characteristics and outcome of patients with difficult weaning from mechanical ventilation: an 18 years' experience of a respiratory intermediate unit attached to a pulmonary department.
abstract: BACKGROUND
  Respiratory dysfunction often persists in post intensive care unit (ICU) patients and intermediate care facilities have been established to ensure the continuous of appropriate care.
  
  
  METHODS
  The data of patients with difficult weaning from mechanical ventilation admitted to a respiratory intermediate unit (RIU) attached to a pulmonary department of a General Hospital, were retrospectively analyzed. Clinical characteristics, weaning from mechanical ventilation and tracheostomy, ICU readmission and RIU mortality were examined over a period of 18 years (1993- 2010) that was randomly divided into three six-year-periods.
  
  
  RESULTS
  A total of 548 patients (age 56.7±17.9 years) [mean ± standard deviation (SD)], of whom 80% with tracheostomy in place and 37.6% with pressure ulcers, were examined. The ICU stay was 30.1±24.7 days (mean ± SD) and increased over time (p<0.05). Patients' baseline disorders were: chronic respiratory disease (41.3%), chronic cardiovascular diseases (10.6%), neuromuscular disease (22.8%) and miscellaneous (25.3%). The length of RIU stay (22.8±19.5 days) was constant over the examined periods but an increase in age and maintenance of tracheostomy were observed; 80% of patients were liberated from mechanical ventilation and 58.5% from tracheostomy, whereas the RIU mortality was 15%.
  
  
  CONCLUSIONS
  In their vast majority patients with chronic respiratory failure, who were admitted to RIU,were weaned from mechanical ventilation, although in a substantial percentage the maintenance of tracheostomy was mandatory after discharge. Hippokratia 2015, 19 (1): 37-40.
authors.affiliation: Pulmonary Department, 'G. Papanikolaou' General Hospital, Thessaloniki, Greece.
authors.forename: V
authors.initials: V
authors.lastname: Tsara
authors.affiliation: Pulmonary Department, 'G. Papanikolaou' General Hospital, Thessaloniki, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Moisiadis
authors.affiliation: Pulmonary Department, 'G. Papanikolaou' General Hospital, Thessaloniki, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Antoniadou
authors.affiliation: Pulmonary Department, 'G. Papanikolaou' General Hospital, Thessaloniki, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Serasli
keywords: RICU; Respiratory intermediate unit; chronic respiratory failure; mechanical ventilation; tracheostomy