title: A new definition of biological effective dose: The dose distribution effects.
abstract: A new biological effective dose (BED) is proposed in this note. This new BED definition takes into account the fact that dose distribution is non-uniform for tumors in patients' treatments. This new BED can be calculated from the dose distribution within a tumor, making it practical and useful for clinical applications.
authors.affiliation: Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: Qinghui.zhang@gmail.com.
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Suqing
authors.initials: S
authors.lastname: Tian
authors.affiliation: Italian National Research Council - IBFM, Milan, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Borasi
mesh_terms: D006801:Humans; D011829:Radiation Dosage; D012015:Reference Standards; D012062:Relative Biological Effectiveness; D009626:Terminology as Topic
keywords: Biological effective dose; Dose volume histogram; Linear quadratic model; Stereotactic body radiation therapy