title: The Use of Mathematical Modelling for Improving the Tissue Engineering of Organs and Stem Cell Therapy.
abstract: Regenerative medicine is a multidisciplinary field where continued progress relies on the incorporation of a diverse set of technologies from a wide range of disciplines within medicine, science and engineering. This review describes how one such technique, mathematical modelling, can be utilised to improve the tissue engineering of organs and stem cell therapy. Several case studies, taken from research carried out by our group, ACTREM, demonstrate the utility of mechanistic mathematical models to help aid the design and optimisation of protocols in regenerative medicine.
authors.forename: Greg
authors.initials: G
authors.lastname: Lemon
authors.forename: Sebastian
authors.initials: S
authors.lastname: Sjoqvist
authors.forename: Mei Ling
authors.initials: ML
authors.lastname: Lim
authors.forename: Neus
authors.initials: N
authors.lastname: Feliu
authors.forename: Alexandra B
authors.initials: AB
authors.lastname: Firsova
authors.forename: Risul
authors.initials: R
authors.lastname: Amin
authors.forename: Ylva
authors.initials: Y
authors.lastname: Gustafsson
authors.forename: Annika
authors.initials: A
authors.lastname: Stuewer
authors.forename: Elena
authors.initials: E
authors.lastname: Gubareva
authors.forename: Johannes
authors.initials: J
authors.lastname: Haag
authors.forename: Philipp
authors.initials: P
authors.lastname: Jungebluth
authors.affiliation: Laboratory of Bioengineering and Regenerative Medicine, Kazan Federal University, Kazan, Russia.
authors.forename: Paolo
authors.initials: P
authors.lastname: Macchiarini
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D009928:Organ Specificity; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry