title: A predictable but life-threatening complication of hydroxyurea in a patient with sickle cell anaemia: an experience learned from a Jehovah's Witness.
abstract: It is well known that hydroxyurea can cause pancytopaenia secondary to bone marrow suppression, which is reversible with short-term discontinuation of the therapy. However, it is important to note that bone marrow suppressive effects caused by hydroxyurea could be easily potentiated in patients with sickle cell anaemia complicated by chronic kidney disease (CKD). We present a case of a Jehovah's Witness with sickle cell anaemia, who developed severe bone marrow suppression due to the combined effects of hydroxyurea and CKD, resulting in a prolonged recovery period after discontinuation of hydroxyurea.
authors.affiliation: Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, New York, USA.
authors.forename: Aung Myint
authors.initials: AM
authors.lastname: Tun
authors.affiliation: St George's University School of Medicine, St. George's, Grenada.
authors.forename: Ei Ei
authors.initials: EE
authors.lastname: Naing
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, The Brooklyn Hospital Center, Brooklyn, New York, USA.
authors.forename: Nay Min
authors.initials: NM
authors.lastname: Tun
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, The Brooklyn Hospital Center, Brooklyn, New York, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Guevara
mesh_terms: D000755:Anemia, Sickle Cell / Q000188:drug therapy* / Q000628:therapy; D001803:Blood Transfusion; D001853:Bone Marrow; D001855:Bone Marrow Diseases / Q000209:etiology*; D004791:Enzyme Inhibitors / Q000009:adverse effects; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D033221:Jehovah's Witnesses; D008297:Male; D008875:Middle Aged; D012068:Religion and Medicine; D051436:Renal Insufficiency, Chronic / Q000150:complications*
chemical_list: D004791:Enzyme Inhibitors; D006918:Hydroxyurea