title: Damarane-type Saponins from Gynostemma longipes and their Cytotoxic Activity.
abstract: Two new damarane-type saponins, named gylongiposides II-III (1 and 2), along with one known compound, (23S)-3β,20ξ,21ξ-trihydroxy-19-oxo-21,23-epoxydammar-24-ene 3-O-α-L-rhamnopyranosyl-(1-->2)-[-D-xylopyranosyl-(1-->3)]-α-L-arabinopyranoside, were isolated from the leaves of Gynostemma longipes C.Y.Wu. Their structures were determined by 1D- and 2D-NMR and HR-ESI-MS spectra. Compounds 1-3 exhibited moderate activity against four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7, with IC50 values ranging from 9.8 +/- 2.1 to 49.6 +/- 2.6 μM.
authors.forename: Pham Tuan
authors.initials: PT
authors.lastname: Anh
authors.forename: Pham Thank
authors.initials: PT
authors.lastname: Ky
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Cue
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Pham Hai
authors.initials: PH
authors.lastname: Yen
authors.forename: Tran Minh
authors.initials: TM
authors.lastname: Ngoc
authors.forename: Hoang Le Tuan
authors.initials: Hle T
authors.lastname: Anh
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Do Thi
authors.initials: do T
authors.lastname: Trang
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D029774:Gynostemma / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins