title: Clinical trials: Early phase clinical trials-are dose expansion cohorts needed?
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 485 Lexington Avenue, New York, NY 10065, USA.
authors.forename: Alexia
authors.initials: A
authors.lastname: Iasonos
authors.affiliation: University Pierre and Marie Curie-Paris 6, 4 Place Jussieu, 75005 Paris, France.
authors.forename: John
authors.initials: J
authors.lastname: O'Quigley
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D017321:Clinical Trials, Phase I as Topic / Q000706:statistics & numerical data*; D015331:Cohort Studies; D006801:Humans; D020714:Maximum Tolerated Dose; D009369:Neoplasms / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D018401:Sample Size
chemical_list: D000970:Antineoplastic Agents