title: Palladium-catalyzed cross-coupling reaction of azides with isocyanides.
abstract: An efficient palladium-catalyzed cross-coupling reaction of azides with isocyanides is developed, providing a general synthetic route to unsymmetric carbodiimides with excellent yields. This method shows a broad substrate scope, including not only aryl azides, but also unactivated benzyl and alkyl azides. Furthermore, from readily available substrates, Pd-catalyzed coupling with a tandem amine insertion cascade to obtain unsymmetric trisubstituted guanidines has been achieved in a one-pot fashion.
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd. 2, Beijing 100193, People's Repubic of China. zhangzhh@cau.edu.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd. 2, Beijing 100193, People's Repubic of China. zhangzhh@cau.edu.cn.
authors.forename: Zongyang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd. 2, Beijing 100193, People's Repubic of China. zhangzhh@cau.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Fu
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd. 2, Beijing 100193, People's Repubic of China. zhangzhh@cau.edu.cn.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Zhang