title: Efficacy and safety of combined cataract surgery with 2 trabecular microbypass stents versus ab interno trabeculotomy.
abstract: OBJECTIVE
  To compare the outcomes of combined cataract surgery with trabecular microbypass stents and ab interno trabeculotomy in patients with open-angle glaucoma.
  
  
  METHODS
  University of Toronto, Toronto, Ontario, and University of Montreal, Montreal, Quebec, Canada, and Glaucoma Associates of Texas, Dallas, Texas, USA.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Patients with primary open-angle, pseudoexfoliative, or pigmentary dispersion glaucoma were included. Primary outcome measures were intraocular pressure (IOP), postoperative medications, success (IOP ≤18 mm Hg, no glaucoma medications or reoperations), and postoperative adverse events.
  
  
  RESULTS
  The average patient age was 76.5 years ± 12 [SD]. Forty-nine eyes had phacoemulsification and 2 had stent implantations; 52 eyes had phacoemulsification and trabeculotomy surgery with a 12-month postoperative follow-up. The analysis of variance indicated a significant reduction in mean IOP from baseline to 12 months for stent (19.6 ± 5.3 mm Hg to 14.3 ± 3.1 mm Hg; P < .001) and trabeculotomy (20.6 ± 6.8 mm Hg to 17.3 ± 6.5 mm Hg; P < .001) and lower mean IOP at 12 months in the stent group (P = .01). The median number of glaucoma medications decreased from baseline to 12 months in both groups and was lower in the stent group at 3, 6, and 12 months. Thirty-nine percent (19 eyes) in the stent group and 14% (7 eyes) in the trabeculotomy group achieved success at 12 months (P = .006). The incidence of hyphema was lower in the stent group (P = .008).
  
  
  CONCLUSIONS
  Both types of surgery achieved a significant reduction in IOP and medication use at 12 months, with the stent group achieving higher success and a reduced incidence of postoperative hyphema.
  
  
  BACKGROUND
  Dr. Ahmed is a consultant to and investigator for Glaukos Corp., Ivantis, Inc., Transcend Medical, Inc., and Aquesys, Inc., and has received speaker honoraria from Neomedix, Inc. Dr. Saheb has received travel funding from Glaukos Corp., Ivantis, Inc., and Transcend Medical, Inc., and a research grant from Ivantis, Inc. Dr. Harasymowycz has received a research grant from Ivantis, Inc. Dr. Fellman is a consultant to Endo Optiks, Inc., and has received honoraria from Optous and research funds from Ivantis, Inc., Glaukos Corp., and Transcend Medical, Inc. No other author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the University of Toronto (Khan), Toronto, Ontario, McGill University Health Centre (Saheb), University of Montreal (Harasymowycz), Montreal, Quebec, and Credit Valley EyeCare (Ahmed), Mississauga, Ontario, Canada; the Glaucoma Center of Texas (Neelakantan) and Glaucoma Associates of Texas (Fellman, Vest), Dallas, Texas, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Khan
authors.affiliation: From the University of Toronto (Khan), Toronto, Ontario, McGill University Health Centre (Saheb), University of Montreal (Harasymowycz), Montreal, Quebec, and Credit Valley EyeCare (Ahmed), Mississauga, Ontario, Canada; the Glaucoma Center of Texas (Neelakantan) and Glaucoma Associates of Texas (Fellman, Vest), Dallas, Texas, USA.
authors.forename: Hady
authors.initials: H
authors.lastname: Saheb
authors.affiliation: From the University of Toronto (Khan), Toronto, Ontario, McGill University Health Centre (Saheb), University of Montreal (Harasymowycz), Montreal, Quebec, and Credit Valley EyeCare (Ahmed), Mississauga, Ontario, Canada; the Glaucoma Center of Texas (Neelakantan) and Glaucoma Associates of Texas (Fellman, Vest), Dallas, Texas, USA.
authors.forename: Arvind
authors.initials: A
authors.lastname: Neelakantan
authors.affiliation: From the University of Toronto (Khan), Toronto, Ontario, McGill University Health Centre (Saheb), University of Montreal (Harasymowycz), Montreal, Quebec, and Credit Valley EyeCare (Ahmed), Mississauga, Ontario, Canada; the Glaucoma Center of Texas (Neelakantan) and Glaucoma Associates of Texas (Fellman, Vest), Dallas, Texas, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Fellman
authors.affiliation: From the University of Toronto (Khan), Toronto, Ontario, McGill University Health Centre (Saheb), University of Montreal (Harasymowycz), Montreal, Quebec, and Credit Valley EyeCare (Ahmed), Mississauga, Ontario, Canada; the Glaucoma Center of Texas (Neelakantan) and Glaucoma Associates of Texas (Fellman, Vest), Dallas, Texas, USA.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Vest
authors.affiliation: From the University of Toronto (Khan), Toronto, Ontario, McGill University Health Centre (Saheb), University of Montreal (Harasymowycz), Montreal, Quebec, and Credit Valley EyeCare (Ahmed), Mississauga, Ontario, Canada; the Glaucoma Center of Texas (Neelakantan) and Glaucoma Associates of Texas (Fellman, Vest), Dallas, Texas, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Harasymowycz
authors.affiliation: From the University of Toronto (Khan), Toronto, Ontario, McGill University Health Centre (Saheb), University of Montreal (Harasymowycz), Montreal, Quebec, and Credit Valley EyeCare (Ahmed), Mississauga, Ontario, Canada; the Glaucoma Center of Texas (Neelakantan) and Glaucoma Associates of Texas (Fellman, Vest), Dallas, Texas, USA. Electronic address: ike.ahmed@utoronto.ca.
authors.forename: Iqbal Ike K
authors.initials: II
authors.lastname: Ahmed
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D054855:Drug-Eluting Stents; D017889:Exfoliation Syndrome / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D020327:Glaucoma Drainage Implants; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods*; D019919:Prosthesis Implantation / Q000379:methods; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D014129:Trabecular Meshwork / Q000601:surgery; D014130:Trabeculectomy / Q000379:methods*