title: Evaluation of Factor VIII as a Risk Factor in Indian Patients with DVT.
abstract: Introduction. Elevated factor VIII population in the Indian population has not been studied as a possible risk factor for deep vein thrombosis (DVT). High factor VIII level is considered a predisposing factor for DVT and its recurrence. However it is known to vary between populations and its exact role in the etiopathogenesis of thrombophilia remains unknown. Material and Methods. Factor VIII levels of patients with DVT who had undergone a prothrombotic workup as a part of their workup was compared to normal age matched controls in a 1 : 3 ratio. Results. There were 75 patients with DVT who had undergone a prothrombotic workup in the course of their treatment for lower limb DVT. In these, 64% had levels of factor VIII more than 150 as compared to 63% of normal controls (p > 0.05, not significant). Conclusion. Elevated factor VIII in the Indians may not be associated with the same thrombotic risk as seen in the West. We find a variation in the levels of factor VIII with a different "normal" than what is reported in other populations. This needs further study to elucidate the role of factor VIII in the evaluation and treatment of thrombophilia.
authors.affiliation: Department of Vascular Surgery, The Christian Medical College, Vellore 632004, India.
authors.forename: Darpanarayan
authors.initials: D
authors.lastname: Hazra
authors.affiliation: Department of Vascular Surgery, The Christian Medical College, Vellore 632004, India.
authors.forename: Indrani
authors.initials: I
authors.lastname: Sen
authors.affiliation: Department of Vascular Surgery, The Christian Medical College, Vellore 632004, India.
authors.forename: Edwin
authors.initials: E
authors.lastname: Stephen
authors.affiliation: Department of Vascular Surgery, The Christian Medical College, Vellore 632004, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Agarwal
authors.affiliation: Department of Transfusion Medicine and Immunohaematology, The Christian Medical College, Vellore 632004, India.
authors.forename: Sukesh Chandran
authors.initials: SC
authors.lastname: Nair
authors.affiliation: Department of Transfusion Medicine and Immunohaematology, The Christian Medical College, Vellore 632004, India.
authors.forename: Joy
authors.initials: J
authors.lastname: Mammen