title: Silica-Supported Oligomeric Benzyl Phosphate (Si-OBP) and Triazole Phosphate (Si-OTP) Alkylating Reagents.
abstract: The syntheses of silica-supported oligomeric benzyl phosphates (Si-OBP(n)) and triazole phosphates (Si-OTP(n)) using ring-opening metathesis polymerization (ROMP) for use as efficient alkylating reagents is reported. Ease of synthesis and grafting onto the surface of norbornenyl-tagged (Nb-tagged) silica particles has been demonstrated for benzyl phosphate and triazole phosphate monomers. It is shown that these silica polymer hybrid reagents, Si-OBP(n) and Si-OTP(n), can be used to carry out alkylation reactions with an array of different nucleophiles to afford the corresponding benzylated and (triazolyl)methylated products in good yield and high purity.
authors.affiliation: Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Maity
authors.affiliation: Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
authors.forename: Saqib
authors.initials: S
authors.lastname: Faisal
authors.affiliation: Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
authors.forename: Alan
authors.initials: A
authors.lastname: Rolfe
authors.affiliation: Materia, Inc. , 60 North San Gabriel Boulevard, Pasadena, California 91107, United States.
authors.forename: Diana
authors.initials: D
authors.lastname: Stoianova
authors.affiliation: Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hanson
mesh_terms: D000478:Alkylation; D001593:Benzyl Compounds / Q000737:chemistry*; D008968:Molecular Conformation; D010316:Particle Size; D010710:Phosphates / Q000138:chemical synthesis / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D014230:Triazoles / Q000737:chemistry*
chemical_list: D001593:Benzyl Compounds; D010710:Phosphates; D014230:Triazoles; D012822:Silicon Dioxide