title: Dominant lethal mutation test in male mice exposed to 900MHz radiofrequency fields.
abstract: Adult male ICR mice were exposed to continuous wave 900MHz radiofrequency fields (RF) at 1.6mW/cm(2) power intensity (whole body average specific absorption rate of 0.731W/kg) for 4 hour/day for 15 days. At the end of exposure, each mouse was caged with 3 mature virgin female mice for mating. After 7 days, each male mouse was transferred to a fresh cage and mated with a second batch of 3 females. This process was repeated for a total of 4 consecutive weeks. Sham exposed male mice and those subjected to an acute 2Gy γ-irradiation (GR) were handled similarly and used as un-exposed and positive controls, respectively. All females were sacrificed on the 18th day of gestation and presumptive mating and, the contents in their uteri were examined. The overall observations during the 4 weeks of mating indicated that the un-exposed female mice mated to RF-exposed male mice showed no significant differences in the percentage of pregnancies, total implants, live implants and dead implants when compared with those mated with sham-exposed mice. In contrast, female mice mated with GR-exposed males showed a consistent pattern of significant differences in the above indices in each and all 4 weeks of mating. Thus, the data indicated an absence of mutagenic potential of RF exposure in the germ cells of male mice.
authors.affiliation: School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu Province, PR China; Laboratory Animal Center, Nantong University, Nantong, Jiangsu Province, PR China. Electronic address: zsx@ntu.edu.cn.
authors.forename: Shunxing
authors.initials: S
authors.lastname: Zhu
authors.affiliation: School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu Province, PR China. Electronic address: zhangjie_78@suda.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Laboratory Animal Center, Nantong University, Nantong, Jiangsu Province, PR China. Electronic address: liuchun@ntu.edu.cn.
authors.forename: Chun
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu Province, PR China. Electronic address: 1041905580@qq.com.
authors.forename: Qina
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of Radiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. Electronic address: vijay@uthscsa.edu.
authors.lastname: Vijayalaxmi
authors.affiliation: Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive,San Antonio, TX 78229, USA. Electronic address: PRIHODAT@uthscsa.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Prihoda
authors.affiliation: School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu Province, PR China. Electronic address: tongjian@suda.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Tong
authors.affiliation: School of Public Health, Soochow University, 199 Renai Road, Suzhou, Jiangsu Province, PR China. Electronic address: yicao@suda.edu.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000818:Animals; D001835:Body Weight; D005260:Female; D005720:Gamma Rays; D005799:Genes, Dominant; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009153:Mutagens; D009154:Mutation; D018812:Paternal Exposure; D011247:Pregnancy; D011270:Pregnancy, Animal; D011846:Radio Waves
chemical_list: D009153:Mutagens
keywords: Dominant Lethal Mutations; Mice; Radiofrequency Fields