title: Antithrombotic activity of fractions and components obtained from raspberry leaves (Rubus chingii).
abstract: The 70% ethanol fraction from an aqueous extract of raspberry leaves was shown to be the most antithrombotic fraction in in vitro and in vivo tests. The total flavonoids and phenolics in this fraction were 0.286g/g and 0.518g/g by colorimetry. Six compounds, including salicylic acid, kaempferol, quercetin, tiliroside, quercetin 3-O-β-d-glucopyranoside and kaempferol 3-O-β-d-glucopyranoside, were isolated from the active fraction. Among them, kaempferol, quercetin and tiliroside obviously delayed plasma recalcification time (PRT) in blood.
authors.affiliation: Department of Pharmacognosy, Shenyang Pharmaceutical University, 48#, Wenhua Road 103, Shenhe District, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Han
authors.affiliation: Department of Pharmacognosy, Shenyang Pharmaceutical University, 48#, Wenhua Road 103, Shenhe District, PR China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Pharmacognosy, Shenyang Pharmaceutical University, 48#, Wenhua Road 103, Shenhe District, PR China.
authors.forename: Chun
authors.initials: C
authors.lastname: Ye
authors.affiliation: Department of Pharmacognosy, Shenyang Pharmaceutical University, 48#, Wenhua Road 103, Shenhe District, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Pharmacognosy, Shenyang Pharmaceutical University, 48#, Wenhua Road 103, Shenhe District, PR China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Pharmacognosy, Shenyang Pharmaceutical University, 48#, Wenhua Road 103, Shenhe District, PR China. Electronic address: yinjun2002@yahoo.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
mesh_terms: D005343:Fibrinolytic Agents / Q000032:analysis / Q000737:chemistry*; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D065856:Rubus / Q000737:chemistry*
chemical_list: D005343:Fibrinolytic Agents; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts
keywords: Antithrombotic activity; Flavonoids; Raspberry leaves