title: Metastatic lobular carcinoma of breast mimics primary cervix carcinoma: two case reports and a review of the literature.
abstract: Invasive lobular carcinoma (ILC) of the breast exhibits unusual clinicopathological, radiological, histological, and metastatic patterns. We present here two cases of ILC of the breast that presented with an unusual pattern of metastasis involving the uterus. Our first patient presented to her primary gynaecologist with profuse vaginal bleeding and underwent total abdominal hysterectomy and bilateral salpingo-oophrectomy. She had fibroadenoma excised from her left breast four years previously. Histopathology revealed lobular carcinoma diffusely infiltrating uterus, cervix, and bilateral ovaries. Retrospective examination of the left breast showed induration along the previous fibroadenoma excision scar. A biopsy from the scar suggested lobular carcinoma. Our second patient presented with a hard indurated cervix mass that mimicked primary cervix carcinoma. She had ILC of the right breast four years previously for which she underwent mastectomy followed by adjuvant chemotherapy and radiotherapy. She was on tamoxifen. Further evaluation at presentation with imaging showed extensive intra-abdominal disease involving peritoneum with moderate ascites, adnexal masses, and confluent para-aortic nodal mass. A cervix biopsy confirmed metastasis from lobular carcinoma. Metastatic involvement of the genital tract should be considered in women with a history of breast cancer who present with abnormal vaginal bleeding, suspicious pelvic examination, or radiological findings. We suggest such patient be vigorously screened with biopsy even if the patient is disease-free for several years. It is crucial to differentiate the metastasis from primary carcinoma of the genital tract as there are vast differences in the management of each.
authors.affiliation: Department of Medical Oncology, Regional Cancer Centre, Medical College Campus, Post Bag No 2417, Trivandrum 695011, India.
authors.forename: Rajitha
authors.initials: R
authors.lastname: Lokadasan
authors.affiliation: Department of Radiotherapy, Regional Cancer Centre, Trivandrum 695011, India.
authors.forename: K
authors.initials: K
authors.lastname: Ratheesan
authors.affiliation: Department of Pathology, Regional Cancer Centre, Trivandrum 695011, India.
authors.forename: Renu
authors.initials: R
authors.lastname: Sukumaran
authors.affiliation: Department of Pathology, Regional Cancer Centre, Trivandrum 695011, India.
authors.forename: Sindhu P
authors.initials: SP
authors.lastname: Nair
keywords: breast; cervix; endometrium; female genital tract; lobular carcinoma; metastatic