title: Transition-Metal-Free N-Arylation of Pyrazoles with Diaryliodonium Salts.
abstract: A new synthetic method was developed for the N-arylation of pyrazoles using diaryliodonium salts. The transformation does not require any transition-metal catalyst and provides the desired N-arylpyrazoles rapidly under mild reaction condition in the presence of aqueous ammonia solution as a mild base without the use of inert atmosphere. The chemoselectivity of unsymmetric diaryliodonium salts was also explored with large number of examples.
authors.affiliation: MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny 1A, 1117 Budapest (Hungary), Fax: (+36) 1-372-2592.
authors.forename: Zsombor
authors.initials: Z
authors.lastname: Gonda
authors.affiliation: MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny 1A, 1117 Budapest (Hungary), Fax: (+36) 1-372-2592. novakz@elte.hu.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Novák
keywords: amination; heterocycles; iodonium salts; pyrazoles