title: Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis.
abstract: Adult-generated dentate granule neurons have emerged as major contributors to hippocampal plasticity. New neurons are generated from neural stem cells through a complex sequence of proliferation, differentiation, and maturation steps. Development of the new neuron is dependent on the precise temporal activity of transcription factors, which coordinate the expression of stage-specific genetic programs. Here, we review current knowledge in transcription factor-mediated regulation of mammalian neural stem cells and neurogenesis and will discuss potential mechanisms of how transcription factor networks, on one hand, allow for precise execution of the developmental sequence and, on the other hand, allow for adaptation of the rate and timing of adult neurogenesis in response to complex stimuli. Understanding transcription factor-mediated control of neuronal development will provide new insights into the mechanisms underlying neurogenesis-dependent plasticity in health and disease.
authors.affiliation: Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
authors.forename: Ruth
authors.initials: R
authors.lastname: Beckervordersandforth
authors.affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Zhang
authors.affiliation: Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
authors.forename: Dieter Chichung
authors.initials: DC
authors.lastname: Lie
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D049109:Cell Proliferation; D006624:Hippocampus / Q000196:embryology / Q000502:physiology*; D006801:Humans; D051379:Mice; D058953:Neural Stem Cells / Q000378:metabolism; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology; D013569:Synapses / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors