title: Possible influence of AMPD1 on cholinergic neurotransmission and sleep.
abstract: It is known that adenosine excess due to monophosphate deaminase deficiency (AMPD1) can be linked to muscle problems. Recently, Perumal et al., 2014 reported a first case of possible impact of AMPD1 on sleep, REM sleep and cholinergic neurotransmission. We report a second patient with similar sleep complaints: long sleep duration with residual daytime sleepiness and a need to sleep after exercise. On polysomnography we observed a long sleep duration, with high sleep efficiency and a SOREMP; on MSLT a shortened sleep latency and 4 SOREMPS were observed. Frequency power spectral heart rate analysis during slow wave sleep, REM sleep and wakefulness revealed an increased parasympathetic tone. In conclusion, AMPD1 could have a profound influence on cholinergic neurotransmission and sleep; further studies are mandatory.
authors.forename: Bertien
authors.initials: B
authors.lastname: Buyse
authors.forename: Philip
authors.initials: P
authors.lastname: Van Damme
authors.forename: Catharina
authors.initials: C
authors.lastname: Belge
authors.forename: Dries
authors.initials: D
authors.lastname: Testelmans
mesh_terms: D000659:AMP Deaminase / Q000378:metabolism*; D000328:Adult; D059329:Cholinergic Neurons / Q000378:metabolism*; D005260:Female; D006339:Heart Rate; D006801:Humans; D010275:Parasympathetic Nervous System / Q000502:physiology; D017286:Polysomnography; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D009435:Synaptic Transmission; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology; D055815:Young Adult
chemical_list: D000659:AMP Deaminase; C514117:AMPD1 protein, human