title: Radiosynovectomy of Proximal Interphalangeal Joint Synovitis in Rheumatoid Arthritis Treated with Rhenium-188 Labeled Tin-colloid and Imaging with Single-photon Emission Computerized Tomography/Computed Tomography: A First Case Report.
abstract: Rheumatoid arthritis (RA) is a chronic disease that is mainly characterized by the asymmetric erosive synovitis, particularly affecting peripheral joints. Radiation synovectomy or radiosynovectomy (RSV), also known as radiosynoviorthesis was first described in 1950's as an adjuvant treatment for RA. RSV is based on the irradiation of the joint synovium by the intra-articular administration of various β-emitting radiopharmaceuticals. As a generator-produced β-emitting radionuclide, the importance of rhenium-188 (Re-188) for radionuclide therapy is increasing rapidly. There are previous reports which used Re-188 tin colloid in knee joint synovitis, but use of Re-188 tin colloid in small joint is not yet reported. We describe the use of Re-188 tin colloid in a 45-year-old female who presented with right 4(th) proximal interphalangeal joint synovitis due to rheumatoid arthritis.
authors.affiliation: Department of Nuclear Medicine and PET/CT, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Koramadai Karuppusamy
authors.initials: KK
authors.lastname: Kamaleshwaran
authors.affiliation: Department of Rheumatology, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Venkataraman
authors.initials: V
authors.lastname: Rajamani
authors.affiliation: Department of Orthopedics, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Boopathi
authors.initials: B
authors.lastname: Krishnan
authors.affiliation: Radiopharmaceuticals Chemistry Section, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.
authors.forename: Madhav
authors.initials: M
authors.lastname: Mallia
authors.affiliation: Department of Nuclear Medicine and PET/CT, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Kalarikal
authors.affiliation: Department of Nuclear Medicine and PET/CT, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Vyshakh
authors.initials: V
authors.lastname: Mohanan
authors.affiliation: Department of Nuclear Medicine and PET/CT, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.
authors.forename: Ajit Sugunan
authors.initials: AS
authors.lastname: Shinto
keywords: Radiosynovectomy; rhenium-188 tin colloid; single-photon emission computerized tomography/computed tomography; small joint