title: Spatial Moran Models I. Stochastic Tunneling in the Neutral Case.
abstract: We consider a multistage cancer model in which cells are arranged in ad-dimensional integer lattice. Starting with all wild-type cells, we prove results about the distribution of the first time when two neutral mutations have accumulated in some cell in dimensionsd≥ 2, extending work done by Komarova [12] ford= 1.
authors.affiliation: Department of Mathematics, Box 90320, Duke U., Durham NC 27708-0320.
authors.forename: Richard
authors.initials: R
authors.lastname: Durrett
authors.affiliation: Department of Mathematics, Box 90320, Duke U., Durham NC 27708-0320.
authors.forename: Stephen
authors.initials: S
authors.lastname: Moseley
keywords: biased voter model; cancer progression; stochastic tunneling