title: [Early attachement relationships and epigenetic customization].
abstract: Recently, new findings in epigenetic science switched the focus from the observation of physiological intragenomic dynamics to the idea of an environmental co-construction of phenotypic expression. In psichodynamic field, objectual relations and attachement theoreticians emphasized the interpersonal dimension of individual development, focusing the attention on the relational matrix of self organization. The construction of stable affective-behavioral traits throughout different parenting styles has actually found a coincidence in ethological studies, which have explored the epigenetic processes underlying the relationship between caregiving and HPA stress responsiveness. An adequate parenting style seems to support affective regulation throughout psychobiological hidden moderators, which would tend to rebalance the physiological systems homeostasis; an unconfident attachment style would promote, on the other hand, the allostatic load rise. Sites of longlife epigenetic susceptibility have also been identified in humans; although associated with risk of maladaptive developing in adverse environmental conditions, they seem to confer protection under favorable conditions. This persisting possibility of reorganization of stable traits throughout lifetime, which seems to be activated by a relevant environmental input, grant to significant relationships, and to therapeutical one as well, an implicit reconditioning potential which could result into the configuration of new stable affective-behavioral styles.
authors.affiliation: UOS Igiene Mentale delle Relazioni Affettive e del Post Partum, UOC Psichiatria e Psicofarmacologia, DAI Neurologia e Psichiatria, Policlinico Umberto I, Sapienza Università di Roma.
authors.forename: Giordana
authors.initials: G
authors.lastname: Rocchi
authors.affiliation: UOS Igiene Mentale delle Relazioni Affettive e del Post Partum, UOC Psichiatria e Psicofarmacologia, DAI Neurologia e Psichiatria, Policlinico Umberto I, Sapienza Università di Roma.
authors.forename: Valentina
authors.initials: V
authors.lastname: Serio
authors.affiliation: UOS Igiene Mentale delle Relazioni Affettive e del Post Partum, UOC Psichiatria e Psicofarmacologia, DAI Neurologia e Psichiatria, Policlinico Umberto I, Sapienza Università di Roma.
authors.forename: Giuseppe Mattia
authors.initials: GM
authors.lastname: Carluccio
authors.affiliation: UOS Igiene Mentale delle Relazioni Affettive e del Post Partum, UOC Psichiatria e Psicofarmacologia, DAI Neurologia e Psichiatria, Policlinico Umberto I, Sapienza Università di Roma.
authors.forename: Isabella
authors.initials: I
authors.lastname: Marini
authors.affiliation: UOS Igiene Mentale delle Relazioni Affettive e del Post Partum, UOC Psichiatria e Psicofarmacologia, DAI Neurologia e Psichiatria, Policlinico Umberto I, Sapienza Università di Roma.
authors.forename: Valentina
authors.initials: V
authors.lastname: Meuti
authors.affiliation: UOS Igiene Mentale delle Relazioni Affettive e del Post Partum, UOC Psichiatria e Psicofarmacologia, DAI Neurologia e Psichiatria, Policlinico Umberto I, Sapienza Università di Roma.
authors.forename: Michela
authors.initials: M
authors.lastname: Zaccagni
authors.affiliation: UOS Igiene Mentale delle Relazioni Affettive e del Post Partum, UOC Psichiatria e Psicofarmacologia, DAI Neurologia e Psichiatria, Policlinico Umberto I, Sapienza Università di Roma.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Giacchetti
authors.affiliation: UOS Igiene Mentale delle Relazioni Affettive e del Post Partum, UOC Psichiatria e Psicofarmacologia, DAI Neurologia e Psichiatria, Policlinico Umberto I, Sapienza Università di Roma.
authors.forename: Franca
authors.initials: F
authors.lastname: Aceti
mesh_terms: D052636:Allostasis; D019052:Depression, Postpartum / Q000523:psychology*; D057890:Epigenomics; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D009473:Neuronal Plasticity; D009769:Object Attachment; D016487:Parenting / Q000523:psychology*