title: Elevated Hemoglobin Concentration Affects Acute Severe Head Trauma After Recovery from Surgery of Neurologic Function in the Tibetan Plateau.
abstract: BACKGROUND
  Long-lived inhabitants of the plateau region have a higher hemoglobin concentration, which is the leading cause of damage in various organs, especially the nervous system. The aim of this study was to investigate the effect of hemoglobin concentration on mortality and neural functions after decompressive craniectomy in patients with hypoxia.
  
  
  METHODS
  Patients with acute severe head trauma were classified into an elevated hemoglobin concentration group (EHb) and a moderate hemoglobin concentration group (MHb). The survival rate was evaluated by comparing the Glasgow Coma Score on days 1, 3, 7, and 15 after surgery (Kaplan-Meier survival curve). The Glasgow Outcome Scale classification method was used to evaluate recovery of neural function.
  
  
  RESULTS
  The Glasgow Coma Score scores on days 3, 7, and 15 were lower in the EHb group compared with the MHb group (P < 0.05). Mortality was significantly higher in the EHb group compared with the MHb group (P < 0.05). After 6 months, the Glasgow Outcome Scale of the MHb group was significantly higher than that of the EHb group (P < 0.05).
  
  
  CONCLUSIONS
  Elevated hemoglobin concentration has a serious impact on neurologic recovery and mortality, as seen in patients with acute severe head trauma after decompressive craniectomy.
authors.affiliation: Department of Neurosurgery, PLA 115th Hospital, Lin Zhi, Tibet, China. Electronic address: weilinjie8888@163.com.
authors.forename: Linjie
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, PLA 115th Hospital, Lin Zhi, Tibet, China.
authors.forename: Quanhong
authors.initials: Q
authors.lastname: Xi
authors.affiliation: Department of Neurosurgery, PLA 115th Hospital, Lin Zhi, Tibet, China.
authors.forename: Chaoyuan
authors.initials: C
authors.lastname: Wen
authors.affiliation: Department of Neurosurgery, PLA 115th Hospital, Lin Zhi, Tibet, China.
authors.forename: DongPing
authors.initials: D
authors.lastname: Ye
authors.affiliation: Department of Neurosurgery, PLA 115th Hospital, Lin Zhi, Tibet, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000531:Altitude; D001930:Brain Injuries / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D015331:Cohort Studies; D056424:Decompressive Craniectomy; D005260:Female; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000150:complications / Q000401:mortality; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D020127:Recovery of Function; D015996:Survival Rate; D018609:Tibet; D055815:Young Adult
chemical_list: D006454:Hemoglobins
keywords: Acute severe head trauma; Elevated hemoglobin concentration group; Hemoglobin concentration; Moderate hemoglobin concentration group