title: Matrix metalloproteinases and psychosocial factors in acute coronary syndrome patients.
abstract: Psychosocial factors have been linked to cardiovascular diseases independently of traditional risk factors. The impact of psychosocial factors on plaque destabilizing factors, such as matrix metalloproteinases (MMPs) has been proposed although scarcely studied.
  
  
  OBJECTIVE
  To evaluate the relationships between hostility, perceived stress and social support with MMPs activity in patients after an Acute Myocardial Infarction (AMI).
  
  
  METHODS
  Blood samples were obtained from 76 patients on admission, post-angioplasty, 24h, 7 days and 3 months after AMI. Hostility, perceived stress and social support were evaluated by validated questionnaires.
  
  
  RESULTS
  Social support was positively correlated with patientś ejection fraction (r=0.453, p=0.009). Patients with higher infarct size presented increased MMP-2 activity at admission (p=0.04). Patients with one diseased vessel had more social support than those with three diseased vessels (p=0.05). The highest values of MMP-2 and MMP-9 activity were observed at the acute event, decreasing, with the lowest activity at 3 months post-AMI (p<0.001). Only in patients with low social support, hostility correlated with MMP-2 activity, from AMI onset (r=0.645, p=0.013), to 7 days post AMI (r=0.557, p=0.038). Hostility explained up to 28% of the variance in MMP-2 activity (R(2)=0.28, p=0.005). Finally, in patients with high hostility, MMP-9 was positively correlated with IL-1β (r=0.468, p=0.02).
  
  
  CONCLUSIONS
  This study adds weight to the idea that two psychosocial factors, namely hostility and social support, acting jointly, may affect MMP-2 activity. Moreover, in hostile patients, there is a link between IL-1β and MMP-9. These findings support the role of psychosocial factors in plaque destabilization and in the inflammatory process in AMI.
authors.affiliation: Lipids and Atherosclerosis Laboratory, Clinical Biochemistry Department, INFIBIOC, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
authors.forename: Nahuel
authors.initials: N
authors.lastname: Fernandez Machulsky
authors.affiliation: Hemodynamic Unit, Cardiology Division, General Hospital Dr. Cosme Argerich, Buenos Aires, Argentina.
authors.forename: Juan
authors.initials: J
authors.lastname: Gagliardi
authors.affiliation: Endocrinology Laboratory, Clinical Biochemistry Department, INFIBIOC, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
authors.forename: Bibiana
authors.initials: B
authors.lastname: Fabre
authors.affiliation: Lipids and Atherosclerosis Laboratory, Clinical Biochemistry Department, INFIBIOC, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
authors.forename: Verónica
authors.initials: V
authors.lastname: Miksztowicz
authors.affiliation: Lipids and Atherosclerosis Laboratory, Clinical Biochemistry Department, INFIBIOC, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
authors.forename: Micaela
authors.initials: M
authors.lastname: Lombardo
authors.affiliation: Hemodynamic Unit, Cardiology Division, General Hospital Dr. Cosme Argerich, Buenos Aires, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: García Escudero
authors.affiliation: Hemodynamic Unit, Cardiology Division, General Hospital Dr. Cosme Argerich, Buenos Aires, Argentina.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gigena
authors.affiliation: Hemodynamic Unit, Cardiology Division, General Hospital Dr. Cosme Argerich, Buenos Aires, Argentina.
authors.forename: Federico
authors.initials: F
authors.lastname: Blanco
authors.affiliation: Institute of Cardiovascular Physiopathology and Department of Pathology, Faculty of Medicine, University of Buenos Aires, Argentina.
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Gelpi
authors.affiliation: Lipids and Atherosclerosis Laboratory, Clinical Biochemistry Department, INFIBIOC, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
authors.forename: Laura
authors.initials: L
authors.lastname: Schreier
authors.affiliation: Behavior Medicine, Faculty of Medicine & Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
authors.forename: Yori
authors.initials: Y
authors.lastname: Gidron
authors.affiliation: Lipids and Atherosclerosis Laboratory, Clinical Biochemistry Department, INFIBIOC, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina. Electronic address: gaberg@ffyb.uba.ar.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Berg
mesh_terms: D054058:Acute Coronary Syndrome / Q000378:metabolism* / Q000523:psychology / Q000628:therapy; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D003402:Creatine Kinase / Q000378:metabolism; D052279:Creatine Kinase, MB Form / Q000378:metabolism; D005260:Female; D006791:Hostility; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000523:psychology / Q000628:therapy; D011446:Prospective Studies; D012944:Social Support; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology
chemical_list: C508585:IL1B protein, human; D053583:Interleukin-1beta; D002097:C-Reactive Protein; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D020782:Matrix Metalloproteinases; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; D006854:Hydrocortisone
keywords: Acute coronary syndrome; Hostility; Metalloproteinase; Social support