title: The role of miRNAs in endometrial cancer.
abstract: miRNAs are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Since their discovery, miRNAs have been associated with every cell function including malignant transformation and metastasis. Endometrial cancer is the most common gynecologic malignancy. However, improvement should be made in interobserver agreement on histological typing and individualized therapeutic approaches. This article summarizes the role of miRNAs in endometrial cancer pathogenesis and treatment.
authors.affiliation: Second Department of Internal Medicine & Research Institute, Hematology Unit, Athens University Medical School, Attikon University Hospital, Athens, Greece.
authors.forename: Diamantina
authors.initials: D
authors.lastname: Vasilatou
authors.affiliation: GAIA Maternity Hospital, Maroussi, Athens, Greece.
authors.forename: Vasileios D
authors.initials: VD
authors.lastname: Sioulas
authors.affiliation: Second Department of Internal Medicine & Research Institute, Hematology Unit, Athens University Medical School, Attikon University Hospital, Athens, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Pappa
authors.affiliation: Second Department of Internal Medicine & Research Institute, Hematology Unit, Athens University Medical School, Attikon University Hospital, Athens, Greece.
authors.forename: Sotirios G
authors.initials: SG
authors.lastname: Papageorgiou
authors.affiliation: 2nd Department of Obstetrics & Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Nikolaos F
authors.initials: NF
authors.lastname: Vlahos
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis; D034622:RNA Interference; D016896:Treatment Outcome
chemical_list: D035683:MicroRNAs
keywords: endometrial cancer; metastasis; miR-200; miRNAs