title: [Clinical value of CA 15-3 for early detection of relapse in locally advanced breast cancer].
abstract: This retrospective study evaluates the interest of CA 15-3 measurement for early detection of breast cancer recurrences. Among 804 patients with invasive breast cancer we selected 117 patients without recurrence (WR) for 5 years or more, 33 with a local recurrence (LR) and 149 with at least one distant metastasis (DM). The sensitivity of CA 15-3 depends on the type of recurrence ([LR] or [DM]), the localization of unique DM, the presence and the number of metastatic sites, on hormonal receptor status and tumor subtypes. The number of metastatic sites and hormonal receptor status are independent predictive criteria of an elevation of CA 15-3. The analysis of ROC curve in order to separate patients with DM and patients WR shows an AUC of 0.87 (p<0.0001). The optimal discriminative threshold is 26 kU/L. In conclusion, these data confirm that CA 15-3 increase depends on the kind of evolution and on initial tumor's hormonal status.
authors.affiliation: Centre Georges-François-Leclerc, département de biologie et pathologie des tumeurs, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Konan
authors.affiliation: Centre Georges-François-Leclerc, département de biologie et pathologie des tumeurs, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Goussot
authors.affiliation: Centre Georges-François-Leclerc, département d'oncologie médicale, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Desmoulins
authors.affiliation: Centre Georges-François-Leclerc, département d'oncologie médicale, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Lorgis
authors.affiliation: Centre Georges-François-Leclerc, département de chirurgie, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Coutant
authors.affiliation: Centre Georges-François-Leclerc, département d'oncologie médicale, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fumoleau
authors.affiliation: Centre Georges-François-Leclerc, département de biologie et pathologie des tumeurs, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Beltjens
authors.affiliation: Centre Georges-François-Leclerc, unité biostatistique et qualité de vie, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Dalban
authors.affiliation: Centre Georges-François-Leclerc, département de biologie et pathologie des tumeurs, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.
authors.forename: Sarab
authors.initials: S
authors.lastname: Lizard
authors.affiliation: Centre Georges-François-Leclerc, département de biologie et pathologie des tumeurs, 1, rue de Pr.-Marion, 21079 Dijon cedex, France. Electronic address: jmriedinger@cgfl.fr.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Riedinger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012044:Regression Analysis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D018396:Mucin-1
keywords: Breast cancer; CA 15-3; Cancer du sein; HER2; Hormonal status; Recurrence; Récepteurs hormonaux; Récidive