title: Hyperforin alleviates mood deficits of adult rats suffered from early separation.
abstract: In this study, we aimed to explore the effect of hyperforin (Hyp) on adult rats suffered from early separation. Wistar infant rats were randomly divided into three groups: control group (CON), early separation from parents group (ESP), and early separation from parents+treatment with 3mg/kg/day Hyp group (ESP+Hyp). Postnatal rats of ESP group and ESP+Hyp group were separated from their mothers for 6h every day on the 14th day after birth, and this separation lasted for 3 weeks, while rats of CON group had no separation. Hyperforin was intragastric administrated on the 21th day after birth, and lasted for 2 weeks in ESP+Hyp group. After separation, adult rats were evaluated by using the open field test (OFT), novelty suppressed feeding test (NSF) and forced swimming test (FST). In OFT, time spent in central grids was much shorter in ESP group compared with that of CON group. After treatment with hyperforin, time spent in central area was much longer compared with that of ESP group. In NSF, the feeding latency of ESP group was much longer than that of CON group. After treatment with hyperforin, the feeding latency was shorter compared with that of ESP group. In FST, score of ESP group was markedly higher than that of CON group. Interestingly, the score was obviously lower in ESP+Hyp group than that of ESP group. In conclusion, these results suggest that hyperforin is able to alleviate anxiety and remit depression in ESP rats.
authors.affiliation: School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Tumor Microenvironment and Neuro-vascular Regulation, Nankai University, Tianjin 300071, China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Zhu
authors.affiliation: School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Tumor Microenvironment and Neuro-vascular Regulation, Nankai University, Tianjin 300071, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Tumor Microenvironment and Neuro-vascular Regulation, Nankai University, Tianjin 300071, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Qin
authors.affiliation: School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Tumor Microenvironment and Neuro-vascular Regulation, Nankai University, Tianjin 300071, China. Electronic address: zhuoyang@nankai.edu.cn.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D005106:Exploratory Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008426:Maternal Deprivation; D019964:Mood Disorders / Q000188:drug therapy* / Q000523:psychology; D009043:Motor Activity / Q000187:drug effects; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017208:Rats, Wistar; D013729:Terpenes / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D013729:Terpenes; D010696:Phloroglucinol; C001654:hyperforin
keywords: Anxiety; Depression; Early separation from parents; Hyperforin