title: Combined Therapeutic and Monitoring Ultrasonic Catheter for Cardiac Ablation Therapies.
abstract: This study evaluated the feasibility of a combined therapeutic and diagnostic ultrasonic catheter for cardiac ablation therapies. Ultrasound can be used to determine when diseased cardiac tissues have become fully coagulated through a method known as local harmonic motion imaging (LHMI). LHMI is an imaging modality for treatment monitoring that uses acoustic radiation force, displacement tracking and the different mechanical properties of viable and ablated tissues. In this study, we developed catheters that are capable of LHMI measurements. Experiments were conducted in phantoms, ex vivo cardiac samples and the in vivo beating hearts of healthy porcine subjects. In vivo experiments revealed that four of four epicardial sonications revealed a decrease in measured displacements from LHMI experiments and that when lower power was used, no lesions formed and there was no corresponding decrease in measured displacement amplitudes. In addition, two of three endocardial lesions were confirmed and corresponded to a decrease in the measured displacement amplitude.
authors.affiliation: Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Electronic address: mcarias@sri.utoronto.ca.
authors.forename: Mathew
authors.initials: M
authors.lastname: Carias
authors.affiliation: Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Kullervo
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation*; D004452:Echocardiography / Q000295:instrumentation*; D005240:Feasibility Studies; D008297:Male; D019047:Phantoms, Imaging; D013552:Swine; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation*
keywords: Arrhythmia; Cardiac ablation; Highintensity focused ultrasound; Local harmonic motion imaging