title: Histone deacetylase inhibitors and epigenetic regulation in lymphoid malignancies.
abstract: A vast majority of lymphomas and leukaemias are results of translocations. These translocations produce various genetic and epigenetic changes that lead to oncogenesis. This opens an opportunity to use a relatively new class of anti-cancer agents, inhibitors of histone deacetylases (HDACi) to target lymphoid malignancies. Surprisingly, the rational basis for treatment of lymphomas with HDACi is far from clear, although some positive results have been obtained. Here we analyze the effect of histone deacetylase (HDAC) inhibitors on lymphoid malignancies.
authors.affiliation: UMR 8126 CNRS, Univ Paris-Sud, Université Paris-Saclay, Institut Gustave Roussy, 94805, Villejuif, France.|LIA1066 « Laboratoire franco-russe de recherche en oncologie », Villejuif, France.
authors.forename: Diana
authors.initials: D
authors.lastname: Markozashvili
authors.affiliation: Institut de Recherche Intégrée en Cancérologie (IRCIV), Institut de Cancérologie Gustave Roussy, Villejuif, France.|Institut National de la Santé et de la Recherche Médicale (INSERM) unité (U) 1009, Université Paris Sud, Institut de Cancérologie Gustave Roussy, 94805, Villejuif, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Ribrag
authors.affiliation: UMR 8126 CNRS, Univ Paris-Sud, Université Paris-Saclay, Institut Gustave Roussy, 94805, Villejuif, France. vassetzky@igr.fr.|LIA1066 « Laboratoire franco-russe de recherche en oncologie », Villejuif, France. vassetzky@igr.fr.
authors.forename: Yegor S
authors.initials: YS
authors.lastname: Vassetzky
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D044127:Epigenesis, Genetic / Q000187:drug effects / Q000235:genetics*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors
keywords: Epigenetics; Histone deacetylase inhibitors; Lymphoma