title: Equisetin, reutericyclin and streptolodygin as natural product lead structures for novel antibiotic libraries.
abstract: The emergence of antimicrobial resistance has created a need for the development of novel antibacterial therapies to treat infection. Natural products that exhibit antibacterial activity offer validated starting points for library generation, and the authors report here that small molecule mimics of tetramate-containing natural products may show antibacterial activity and offer the potential for further optimization.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, Mansfield Rd, University of Oxford, OX1 3TA, UK.
authors.forename: Yong-Chul
authors.initials: YC
authors.lastname: Jeong
authors.affiliation: Chemistry Research Laboratory, University of Oxford, Mansfield Rd, University of Oxford, OX1 3TA, UK.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Moloney
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology; D013720:Tenuazonic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C416127:reutericyclin; C024509:equisetin; D013720:Tenuazonic Acid