title: Total Synthesis of Codeine.
abstract: In this paper, a new strategy towards the synthesis of codeine and morphine is reported. This new approach features a cascade cyclization to construct the dihydrofuran ring, and an intramolecular palladium catalyzed C-H olefination of unactivated aliphatic alkene to install the morphinan ring system.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, No 2, North Cuihu Road, Kunming, Yunnan 650091 (P. R. China).
authors.forename: Qilin
authors.initials: Q
authors.lastname: Li
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, No 2, North Cuihu Road, Kunming, Yunnan 650091 (P. R. China). zhanghb@ynu.edu.cn.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003061:Codeine / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D005663:Furans / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009020:Morphine / Q000138:chemical synthesis / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D005663:Furans; D010165:Palladium; D009020:Morphine; D003061:Codeine
keywords: CH olefination; alkaloids; codeine; palladium; total synthesis