title: Isolation of Monovalerianester A, an Inhibitor of Fat Accumulation, from Valeriana fauriei.
abstract: The rhizomes and roots of Valeriana fauriei were extracted with 80% aqueous ethanol. This extract was found to exhibit potent inhibitory effects on fat accumulation in 3T3-LI murine adipocytes. After several steps of chromatographic purification, we succeeded in identifying monovalerianester A as an inhibitor of fat accumulation. Thus, monovalerianester A and the crude extract of the rhizomes and roots of V. fauriei may have therapeutic potential for the treatment of obesity.
authors.forename: Keiji
authors.initials: K
authors.lastname: Yuki
authors.forename: Mariko
authors.initials: M
authors.lastname: Ikeda
authors.forename: Shosuke
authors.initials: S
authors.lastname: Yoshida
authors.forename: Osamu
authors.initials: O
authors.lastname: Ohno
authors.forename: Kiyotake
authors.initials: K
authors.lastname: Suenaga
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uemura
authors.forename: Kenji
authors.initials: K
authors.lastname: Miyamoto
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D005223:Fats / Q000378:metabolism*; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry*; D014632:Valerian / Q000737:chemistry*
chemical_list: D005223:Fats; D010936:Plant Extracts