title: Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope.
abstract: Optical coherence tomography (OCT) is a useful imaging modality for detecting and monitoring diseases of the gastrointestinal tract and other tubular structures. The non-destructiveness of OCT enables time-serial studies in animal models. While turnkey commercial research OCT systems are plenty, researchers often require custom imaging probes. We describe the integration of a custom endoscope with a commercial swept-source OCT system and generalize this description to any imaging probe and OCT system. A numerical dispersion compensation method is also described. Example images demonstrate that OCT can visualize the mouse colon crypt structure and detect adenoma in vivo.
authors.affiliation: College of Optical Sciences, The University of Arizona, Tucson, Arizona, United States of America.
authors.forename: Weston A
authors.initials: WA
authors.lastname: Welge
authors.affiliation: College of Optical Sciences, The University of Arizona, Tucson, Arizona, United States of America; Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona, United States of America.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Barton
mesh_terms: D000236:Adenoma / Q000139:chemically induced / Q000175:diagnosis*; D000465:Algorithms; D000818:Animals; D001397:Azoxymethane; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000175:diagnosis*; D019723:Endoscopes; D004724:Endoscopy / Q000295:instrumentation / Q000379:methods*; D008815:Mice, Inbred Strains; D008962:Models, Theoretical; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*
chemical_list: D002273:Carcinogens; D001397:Azoxymethane