title: Antioxidant status in women with uterine leiomyoma: relation with sex hormones.
abstract: Uterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients with leiomyoma are influenced by changes in sex hormones and gonadotropins (estradiol (E2), progesterone, FSH, and LH) during menstrual cycle and in postmenopause. The material consisted of blood and uterine tissue specimens. Hormone concentrations were determined and assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and lipid hydroperoxides concentration were performed. In blood of examined women, a significant difference in catalase, glutathione peroxidase and glutathione reductase activity was recorded among the phases. There was also a positive correlation between the estradiol/progesterone concentration and the catalase activity. Progesterone negatively correlated with lipid hydroperoxides level. In myoma tissue, we recorded a phase-related difference in lipid hydroperoxides level and activities of superoxide dismutase, glutathione peroxidase activities, and glutathione reductase. Negative correlation was observed between FSH and glutathione peroxidase. The results suggest that antioxidant status in patients with uterine leiomyoma is influenced by the changes in sex hormones during the menstrual cycle and in postmenopause, indicating a role of the observed relationship in the leiomyoma etiology.
authors.affiliation: "Vinča" Institute of Nuclear Sciences, Belgrade, RS.
authors.forename: Snežana
authors.initials: S
authors.lastname: Pejić
authors.affiliation: "Vinča" Institute of Nuclear Sciences, Belgrade, RS.
authors.forename: Ana
authors.initials: A
authors.lastname: Todorović
authors.affiliation: "Vinča" Institute of Nuclear Sciences, Belgrade, RS.
authors.forename: Vesna
authors.initials: V
authors.lastname: Stojiljković
authors.affiliation: "Vinča" Institute of Nuclear Sciences, Belgrade, RS.
authors.forename: Ljubica
authors.initials: L
authors.lastname: Gavrilović
authors.affiliation: "Vinča" Institute of Nuclear Sciences, Belgrade, RS.
authors.forename: Nataša
authors.initials: N
authors.lastname: Popović
authors.affiliation: "Vinča" Institute of Nuclear Sciences, Belgrade, RS.
authors.forename: Snežana B
authors.initials: SB
authors.lastname: Pajović
mesh_terms: D000328:Adult; D005260:Female; D012739:Gonadal Steroid Hormones / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007889:Leiomyoma / Q000201:enzymology* / Q000378:metabolism; D008597:Menstrual Cycle / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000032:analysis* / Q000378:metabolism; D017698:Postmenopause / Q000378:metabolism; D014594:Uterine Neoplasms / Q000201:enzymology*
chemical_list: D012739:Gonadal Steroid Hormones; D010088:Oxidoreductases