title: Effect of GBA Mutations on Phenotype of Parkinson's Disease: A Study on Chinese Population and a Meta-Analysis.
abstract: GBA has been identified as a genetic risk factor for PD. Whether the clinical manifestations of PD patients with or without GBA mutations are different has still not reached a consensus. We firstly detected the GBA mutation L444P in 1147 Chinese PD patients and simultaneously evaluated their corresponding clinical data. Then we compared the phenotypes between 646 PD patients with GBA mutations and 10344 PD patients without GBA mutations worldwide through meta-analysis. Through the method of meta-analysis, there was significant difference in age at onset (MD = -3.10 [95% CI: -4.88, -1.32]), bradykinesia as an initial symptom (OR = 1.49 [95% CI: 1.15, 1.94]), having family history (OR = 1.50 [95% CI: 1.18, 1.91]), and dementia (OR = 3.21 [95% CI: 1.97, 5.24]) during the comparison between PD patients with and without GBA mutations. While, in the aspect of tremor as an initial symptom (OR = 0.81 [95% CI: 0.64, 1.03]), the severity of motor symptoms such as H-Y (MD = 0.06 [95% CI: -0.06, 0.17]) and UPDRS-III (MD = 1.61 [95% CI: -0.65, 3.87]) and having dyskinesia (OR = 1.60 [95% CI: 0.90, 2.84]) during the comparison between the two groups revealed no statistical differences. Our results suggested that the phenotypes of PD patients with GBA mutations are different from GBA noncarriers.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Changsha, Hunan 410008, China.
authors.forename: Qi-Ying
authors.initials: QY
authors.lastname: Sun
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shu
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Changsha, Hunan 410008, China ; State Key Laboratory of Medical Genetics, Changsha, Hunan 410008, China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Guo
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Changsha, Hunan 410008, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Changsha, Hunan 410008, China.
authors.forename: Xin-Xiang
authors.initials: XX
authors.lastname: Yan
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Changsha, Hunan 410008, China ; State Key Laboratory of Medical Genetics, Changsha, Hunan 410008, China ; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital University of Medical Sciences, Beijing 100069, China.
authors.forename: Bei-Sha
authors.initials: BS
authors.lastname: Tang