title: Effects of artemisinin sustained-release granules on mixed alga growth and microcystins production and release.
abstract: To safely and effectively apply artemisinin sustained-release granules to control and prevent algal water-blooms, the effects of artemisinin and its sustained-release granules on freshwater alga (Scenedesmus obliquus (S. obliquus) and Microcystis aeruginosa (M. aeruginosa)), as well as the production and release of microcystins (MCs) were studied. The results showed that artemisinin sustained-release granules inhibited the growth of M. aeruginosa (above 95% IR) and S. obliquus (about 90% IR), with M. aeruginosa more sensitive. The artemisinin sustained-release granules had a longer inhibition effect on growth of pure algae and algal coexistence than direct artemisinin dosing. The artemisinin sustained-release granules could decrease the production and release of algal toxins due to the continued stress of artemisinin released from artemisinin sustained-release granules. There was no increase in the total amount of MC-LR in the algal cell culture medium.
authors.affiliation: Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, 210098, Nanjing, China. nilixiao@hhu.edu.cn.
authors.forename: Lixiao
authors.initials: L
authors.lastname: Ni
authors.affiliation: Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, 210098, Nanjing, China.
authors.forename: Danye
authors.initials: D
authors.lastname: Li
authors.affiliation: Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, 210098, Nanjing, China.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Hu
authors.affiliation: Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, 210098, Nanjing, China.
authors.forename: Peifang
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Environmental Science and Engineering, School of Geography Science, Nanjing Normal University, 210097, Nanjing, China.
authors.forename: Shiyin
authors.initials: S
authors.lastname: Li
authors.affiliation: Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, 210098, Nanjing, China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, 210098, Nanjing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Desert Research Institute, Las Vegas, NV, 89119, USA.
authors.forename: Kumud
authors.initials: K
authors.lastname: Acharya
mesh_terms: D037621:Artemisinins / Q000494:pharmacology*; D000460:Chlorophyta / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000494:pharmacology; D005068:Eutrophication; D052998:Microcystins / Q000096:biosynthesis / Q000378:metabolism*; D046931:Microcystis / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
chemical_list: D037621:Artemisinins; D003692:Delayed-Action Preparations; D052998:Microcystins; C031327:artemisinin
keywords: Algal coexistence; Artemisinin sustained-release granules; Microcystins; Production; Release