title: Amyotrophic lateral sclerosis progression: Iran-ALS clinical registry, a multicentre study.
abstract: This study was designed to evaluate ALS progression among different subgroups of Iranian patients. Three hundred and fifty-eight patients from centres around the country were registered and their progression rate was evaluated using several scores including Manual Muscle Test scoring (MMT) and the revised ALS Functional Rating Scale (ALSFRS-R). Progression rate was analysed separately in subgroups regarding gender, onset site, stage of disease and riluzole consumption. A significant difference in MMT deterioration rate (p = 0.01) was noted between those who used riluzole and those who did not. No significant difference was observed in progression rates between male/female and bulbar-onset/limb-onset groups using riluzole. In conclusion, riluzole has a significant effect on muscle force deterioration rate but not functional scale. Progression rate was not influenced by site of onset or gender.
authors.affiliation: a Iranian Center of Neurological Research, Department of Neurology , Tehran University of Medical Sciences , Tehran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Shamshiri
authors.affiliation: a Iranian Center of Neurological Research, Department of Neurology , Tehran University of Medical Sciences , Tehran.
authors.forename: Farzad
authors.initials: F
authors.lastname: Fatehi
authors.affiliation: b Department of Community Medicine , Iran University of Medical Sciences , Tehran.
authors.forename: Farnoush
authors.initials: F
authors.lastname: Davoudi
authors.affiliation: c Sanofi-Medical Department , Tehran.
authors.forename: Elham
authors.initials: E
authors.lastname: Mir
authors.affiliation: c Sanofi-Medical Department , Tehran.
authors.forename: Behin
authors.initials: B
authors.lastname: Pourmirza
authors.affiliation: a Iranian Center of Neurological Research, Department of Neurology , Tehran University of Medical Sciences , Tehran.
authors.forename: Roya
authors.initials: R
authors.lastname: Abolfazli
authors.affiliation: d Department of Neurology , Isfahan University of Medical Sciences , Isfahan.
authors.forename: Masoud
authors.initials: M
authors.lastname: Etemadifar
authors.affiliation: a Iranian Center of Neurological Research, Department of Neurology , Tehran University of Medical Sciences , Tehran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Harirchian
authors.affiliation: e Department of Neurology , Shahid Beheshti Medical University.
authors.forename: Koroush
authors.initials: K
authors.lastname: Gharagozli
authors.affiliation: f Department of Neurology , Tabriz University of Medical Sciences.
authors.forename: Hormoz
authors.initials: H
authors.lastname: Ayromlou
authors.affiliation: d Department of Neurology , Isfahan University of Medical Sciences , Isfahan.
authors.forename: Keivan
authors.initials: K
authors.lastname: Basiri
authors.affiliation: g Department of Neurology , Iran University of Medical Sciences , Tehran.
authors.forename: Babak
authors.initials: B
authors.lastname: Zamani
authors.affiliation: g Department of Neurology , Iran University of Medical Sciences , Tehran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rohani
authors.affiliation: h Department of Neurology , Kerman University of Medical Sciences , Kerman.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Sedighi
authors.affiliation: i Department of Neurology , Gilan University of Medical Sciences.
authors.forename: Ali
authors.initials: A
authors.lastname: Roudbari
authors.affiliation: e Department of Neurology , Shahid Beheshti Medical University.
authors.forename: Hossein
authors.initials: H
authors.lastname: Delavar Kasmaei
authors.affiliation: j Department of Neurology , Mashhad University of Medical Sciences.
authors.forename: Karim
authors.initials: K
authors.lastname: Nikkhah
authors.affiliation: k Aja Medical University , Tehran , Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Ranjbar Naeini
authors.affiliation: a Iranian Center of Neurological Research, Department of Neurology , Tehran University of Medical Sciences , Tehran.
authors.forename: Shahriar
authors.initials: S
authors.lastname: Nafissi
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D010244:Bulbar Palsy, Progressive / Q000209:etiology / Q000503:physiopathology*; D018450:Disease Progression; D005121:Extremities / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011446:Prospective Studies; D012042:Registries; D019782:Riluzole / Q000627:therapeutic use
chemical_list: D018696:Neuroprotective Agents; D019782:Riluzole
keywords: Amyotrophic lateral sclerosis; Manual Muscle Test scoring; progression rate; revised ALS Functional Rating Scale