title: Design, synthesis and structure-activity relationship of novel diphenylamine derivatives.
abstract: Diphenylamine derivatives have been reported with good fungicidal, insecticidal, acaricidal, rodenticidal and/or herbicidal activities. To find new lead compound of this kind, a series of novel diphenylamine derivatives were designed and synthesized by the approach of Intermediate Derivatization Methods. All compounds were identified by (1)H NMR and elemental analysis. Bioassays demonstrated that some compounds substituted at 2,4,6-positions or 2,4,5-positions of phenyl ring B exhibited excellent fungicidal activities. The optimal compounds P30 and P33 showed 80% and 85% control respectively against cucumber downy mildew at 12.5mgL(-1), both 100% control against rice blast at 0.3mgL(-1) and both 100% control against cucumber gray mold at 0.9mgL(-1). The relationship between structure and fungicidal activities was discussed as well.
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd, Shenyang 110021, China.
authors.forename: Huichao
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd, Shenyang 110021, China.
authors.forename: Aiying
authors.initials: A
authors.lastname: Guan
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd, Shenyang 110021, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Huang
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd, Shenyang 110021, China. Electronic address: liuchangling@vip.163.com.
authors.forename: Chang-Ling
authors.initials: CL
authors.lastname: Liu
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd, Shenyang 110021, China.
authors.forename: Zhinian
authors.initials: Z
authors.lastname: Li
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd, Shenyang 110021, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xie
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd, Shenyang 110021, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lan
mesh_terms: D018553:Cucumis sativus / Q000382:microbiology; D004159:Diphenylamine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005658:Fungi / Q000187:drug effects*; D005659:Fungicides, Industrial / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012275:Oryza / Q000382:microbiology; D010935:Plant Diseases / Q000382:microbiology / Q000517:prevention & control*; D013329:Structure-Activity Relationship
chemical_list: D005659:Fungicides, Industrial; D004159:Diphenylamine
keywords: Diphenylamine derivatives; Fungicidal activity; Intermediate Derivatization Methods; Structure–activity relationship