title: Expression of Epithelial-Mesenchymal Transition-related Factors in Adherent Placenta.
abstract: Epithelial-mesenchymal transition is a key process influencing cancer progression and metastasis. The purpose of this study was to investigate the expression of epithelial-mesenchymal transition-related factors in chorionic villi and decidual cells in adherent placenta. The current study included 19 patients diagnosed with adherent placenta after hysterectomy. The expression of E-cadherin, Vimentin, Snail, and transforming growth factor-β in placental tissues was analyzed by immunohistochemical staining. Immunostaining intensity was semiquantitatively evaluated using the HSCORE algorithm. In the chorionic villi of the invasive part (placenta with invasion into myometrium), E-cadherin expression was significantly lower than that in the noninvasive part (placenta with no invasion). In the decidual cells of the invasive part, expression of transforming growth factor-β and Snail significantly increased. These results suggest that epithelial-mesenchymal transition may contribute to excessive trophoblast invasion into the myometrium in adherent placenta.
authors.affiliation: Department of Obstetrics and Gynecology (T.S., Y.M., K.T., H.M., H.Y.), Kobe University Graduate School of Medicine Department of Diagnostic Pathology (F.K., T.I.), Kobe University Hospital, Kobe, Japan.
authors.forename: Tokuro
authors.initials: T
authors.lastname: Shirakawa
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Miyahara
authors.forename: Kenji
authors.initials: K
authors.lastname: Tanimura
authors.forename: Hiroki
authors.initials: H
authors.lastname: Morita
authors.forename: Fumi
authors.initials: F
authors.lastname: Kawakami
authors.forename: Tomoo
authors.initials: T
authors.lastname: Itoh
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010921:Placenta Accreta / Q000473:pathology*; D011247:Pregnancy
chemical_list: D015415:Biomarkers