title: Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance.
abstract: Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In particular, great interest has been given to polyphenols and especially to a specific subset of molecules, i.e. anthocyanins. Several lines of evidence suggest that anthocyanins have positive effects on human health by inducing a number of biological activities. This review will give an overview on the influence of dietary anthocyanins on preventing and managing type 2 diabetes. In particular, in vitro and in vivo studies will be presented. The article also reviews the potential clinical impact of the antidiabetic activity of anthocyanins and outlines the major challenges of using anthocyanins for diabetes treatment.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Turrini
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Ferruzzi
authors.affiliation: Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto, 237 47921 Rimini, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Fimognari
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage* / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000517:prevention & control*; D005638:Fruit / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000187:drug effects; D065089:Glycoside Hydrolase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007333:Insulin Resistance; D018384:Oxidative Stress / Q000187:drug effects; D014675:Vegetables / Q000737:chemistry; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
chemical_list: D000872:Anthocyanins; D017127:Glycation End Products, Advanced; D065089:Glycoside Hydrolase Inhibitors; D000516:alpha-Amylases
keywords: Anthocyanins; anthocyanidins; antioxidant activity; cyanidin; diabetes; enzymatic mechanisms; non-enzymatic
  mechanisms