title: Natural Products and Cancer Stem Cells.
abstract: The development of modern technologies casts a new light on the natural products as an invaluable source of lead compounds that could guide drug discovery. Cancer stem cells are a subpopulation of cancer cells with a high clonogenic capacity and the ability to reform the parental tumours upon transplantation. They have been proposed to drive tumorigenesis and metastases. In this review, we present the ability of forty-nine different natural products to influence the biology of cancer stem cells.
authors.forename: Cristina
authors.initials: C
authors.lastname: Marucci
authors.forename: Gaia
authors.initials: G
authors.lastname: Fumagalli
authors.forename: Francesco
authors.initials: F
authors.lastname: Calogero
authors.forename: Alessandra
authors.initials: A
authors.lastname: Silvani
authors.forename: Michael S
authors.initials: MS
authors.lastname: Christodoulou
authors.forename: Nadine
authors.initials: N
authors.lastname: Martinet
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy. daniele.passarella@unimi.it.
authors.forename: Daniele
authors.initials: D
authors.lastname: Passarella
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D055808:Drug Discovery / Q000379:methods; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000502:physiology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D005419:Flavonoids