title: [Molecular aspects of the pathogenesis and current approaches to pharmacological correction of Alzheimer's disease].
abstract: This review addresses the current hypotheses of the pathogenesis of Alzheimer's disease (AD) and methods of its pharmacological corrections. The following topics are reviewed: a role of ß-amyloid in the pathogenesis of AD, a role of tau-protein in the pathogenesis of AD, main hypotheses of the pathogenesis, the relationship between ß-amyloid and tau-protein, the dysfunction of synapses in AD, a neuroimmune hypothesis, treatment approaches.
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow Region.
authors.forename: M S
authors.initials: MS
authors.lastname: Kukharsky
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow Region.
authors.forename: R K
authors.initials: RK
authors.lastname: Ovchinnikov
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow Region.
authors.forename: S O
authors.initials: SO
authors.lastname: Bachurin
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects; D058990:Molecular Targeted Therapy; D058225:Plaque, Amyloid / Q000378:metabolism; D013569:Synapses / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins