title: Synthesis of N-Aryl β-Amino Alcohols by Trifluoroacetic Acid Promoted Multicomponent Coupling of Aziridines, Arynes, and Water.
abstract: A transition-metal-free, three-component coupling involving N-substituted aziridines, arynes, and water promoted by trifluoroacetic acid (TFA) has been reported. The reaction furnished medicinally important N-aryl β-amino alcohol derivatives in moderate to good yields. In addition, the use of azetidines in this reaction afforded N-aryl γ-amino alcohol derivatives.
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL) , Dr. Homi Bhabha Road, Pune - 411008, India.
authors.forename: Tony
authors.initials: T
authors.lastname: Roy
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL) , Dr. Homi Bhabha Road, Pune - 411008, India.
authors.forename: Dnyaneshwar R
authors.initials: DR
authors.lastname: Baviskar
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL) , Dr. Homi Bhabha Road, Pune - 411008, India.
authors.forename: Akkattu T
authors.initials: AT
authors.lastname: Biju