title: ANARCI: antigen receptor numbering and receptor classification.
abstract: BACKGROUND
  Antibody amino-acid sequences can be numbered to identify equivalent positions. Such annotations are valuable for antibody sequence comparison, protein structure modelling and engineering. Multiple different numbering schemes exist, they vary in the nomenclature they use to annotate residue positions, their definitions of position equivalence and their popularity within different scientific disciplines. However, currently no publicly available software exists that can apply all the most widely used schemes or for which an executable can be obtained under an open license.
  
  
  RESULTS
  ANARCI is a tool to classify and number antibody and T-cell receptor amino-acid variable domain sequences. It can annotate sequences with the five most popular numbering schemes: Kabat, Chothia, Enhanced Chothia, IMGT and AHo.
  
  
  METHODS
  ANARCI is available for download under GPLv3 license at opig.stats.ox.ac.uk/webapps/anarci. A web-interface to the program is available at the same address.
  
  
  BACKGROUND
  deane@stats.ox.ac.uk.
authors.affiliation: Department of Statistics, Oxford University, Oxford, UK.
authors.forename: James
authors.initials: J
authors.lastname: Dunbar
authors.affiliation: Department of Statistics, Oxford University, Oxford, UK.
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Deane
mesh_terms: D000906:Antibodies / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D008958:Models, Molecular; D011948:Receptors, Antigen, T-Cell / Q000145:classification* / Q000235:genetics* / Q000276:immunology; D012984:Software
chemical_list: D000906:Antibodies; D007135:Immunoglobulin Variable Region; D011948:Receptors, Antigen, T-Cell