title: Association of FGFR3 and FGFR4 gene polymorphisms with breast cancer in Chinese women of Heilongjiang province.
abstract: BACKGROUND
  The fibroblast growth factor (FGF) receptor pathway is activated in many tumors. FGFR2 has been identified as a breast cancer susceptibility gene. Common variation in other FGF receptors might also affect breast cancer risk. We carried out a case-control study to investigate associations of variants in FGFR3 and FGFR4 with breast cancer in women from Heilongjiang Province.
  
  
  METHODS
  SNP rs2234909 and rs3135848 in FGFR3 and rs1966265 and rs351855 in FGFR4 were successfully genotyped in 747 breast cancer patients and 716 healthy controls using the SNaPshot method. The associations between SNPs and breast cancer were examined by logistic regression. The associations between SNPs and disease characteristics were examined by chi-square tests or one-way ANOVA as needed.
  
  
  RESULTS
  The minor alleles of rs1966265 and rs351855 in FGFR4 were strongly associated with breast cancer in the population, with odds ratios of 1.335 (95%CI = 1.154-1.545) and 1.364 (95%CI = 1.177-1.580), respectively. However, no significant associations were detected between other SNPs and breast cancer. Analyses of the disease characteristics showed that SNP rs351855 was associated with lymph-node-positive breast cancer with a dose-dependent effect of the minor allele (P = 0.008).
  
  
  CONCLUSIONS
  SNPs rs1966265 and rs351855 in FGFR4 were associated with breast cancer in a northern Chinese population.
authors.affiliation: Department of Breast Surgery, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Yongdong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Breast Surgery, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Breast Surgery, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Department of Breast Surgery, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Yanlv
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Breast Surgery, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Da
authors.initials: D
authors.lastname: Pang
mesh_terms: D000328:Adult; D000483:Alleles; D000704:Analysis of Variance; D044466:Asian People; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics*; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000235:genetics*; D012044:Regression Analysis
chemical_list: C496365:FGFR3 protein, human; C496371:FGFR4 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3; D051499:Receptor, Fibroblast Growth Factor, Type 4
keywords: Chinese; FGFR; breast cancer; genetic susceptibility; polymorphism