title: Wave Intensity Analysis Can Identify Eccentric Cardiac Hypertrophy in Hypertensive Patients With Varied Left Ventricular Configurations.
abstract: OBJECTIVE
  The primary aim of this study was to determine whether wave intensity can discriminate cases of eccentric hypertrophy in patients with essential hypertension who have varied left ventricular configurations.
  
  
  METHODS
  A total of 155 hypertensive patients with different ventricular configurations (27 normal configuration, 42 concentric remodeling, 62 concentric hypertrophy, and 24 eccentric hypertrophy) were recruited. We performed a noninvasive wave intensity analysis of the common carotid artery and conventional echocardiography. Blood pressure and flow velocity were measured in the right carotid artery of all patients.
  
  
  RESULTS
  The left ventricular ejection fraction (LVEF) in the eccentric hypertrophy group was significantly lower than the values in the other groups (P < .05). The R-W1 interval/W1-W2 interval ratio (where W1 indicates the first positive peak and W2 the second positive peak) in the eccentric hypertrophy group was much higher than the values in the other groups (P < .05). However, there were no significant differences in W1, W2, and negative area among these groups. Pearson correlation analysis showed that R-W1/W1-W2, R-W1, and W1-W2were correlated with the LVEF, whereas there was no correlation between W1, W2, negative area, and the reflection coefficient with the LVEF.
  
  
  CONCLUSIONS
  We propose that by using the R-W1/W1-W2 ratio, wave intensity analysis can identify hypertensive patients with eccentric hypertrophy without the need for echocardiography.
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China (G.-Q.D., H.-R.L., S.C., P.D., Y.W., J.-W.T.); and Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China (J.-Y.X.).
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Du
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China (G.-Q.D., H.-R.L., S.C., P.D., Y.W., J.-W.T.); and Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China (J.-Y.X.).
authors.forename: Hai-Ru
authors.initials: HR
authors.lastname: Li
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China (G.-Q.D., H.-R.L., S.C., P.D., Y.W., J.-W.T.); and Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China (J.-Y.X.).
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Xue
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China (G.-Q.D., H.-R.L., S.C., P.D., Y.W., J.-W.T.); and Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China (J.-Y.X.).
authors.forename: Shuang
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China (G.-Q.D., H.-R.L., S.C., P.D., Y.W., J.-W.T.); and Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China (J.-Y.X.).
authors.forename: Pei
authors.initials: P
authors.lastname: Du
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China (G.-Q.D., H.-R.L., S.C., P.D., Y.W., J.-W.T.); and Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China (J.-Y.X.).
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China (G.-Q.D., H.-R.L., S.C., P.D., Y.W., J.-W.T.); and Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China (J.-Y.X.) jiaweitian@126.com.
authors.forename: Jia-Wei
authors.initials: JW
authors.lastname: Tian
mesh_terms: D001795:Blood Pressure Determination / Q000379:methods; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: blood pressure; echocardiography; hypertension; left ventricular configuration; wave intensity