title: Topical application of olive oil macerate of Momordica charantia L. promotes healing of excisional and incisional wounds in rat buccal mucosa.
abstract: OBJECTIVE
  In Turkish folk medicine Momordica charantia L. is used for wound healing. The aim of the present study is to investigate this folkloric knowledge and confirm the plant's potential effect on buccal mucosa wound in the rat.
  
  
  METHODS
  Wound healing activity of olive oil macerate of Momordica charantia L. was investigated in linear incision and circular excision wound models created in the buccal mucosa of the rat. The tissues were histopathologically evaluated, moreover, hydroxyproline contents of the tissues were determined. The anti-inflammatory activity was also assessed by using Whittle method with some modifications.
  
  
  RESULTS
  Olive oil macerate of M. charantia showed significant wound healing activity both in incision (45.1%) and excision (89.8%) wound models and demonstrated anti-inflammatory activity with the inhibition value of 31.3% at the dose of 100mg/kg.
  
  
  CONCLUSIONS
  The experimental data revealed that M. charantia showed significant wound healing and anti-inflammatory effect.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
authors.forename: Mert
authors.initials: M
authors.lastname: İlhan
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.
authors.forename: Ismail Eser
authors.initials: IE
authors.lastname: Bolat
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
authors.forename: İpek
authors.initials: İ
authors.lastname: Süntar
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Harika
authors.initials: H
authors.lastname: Kutluay Köklü
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Dilek A
authors.initials: DA
authors.lastname: Uğar Çankal
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200 Afyonkarahisar, Turkey.
authors.forename: Hikmet
authors.initials: H
authors.lastname: Keleş
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey. Electronic address: esrak@gazi.edu.tr.
authors.forename: Esra
authors.initials: E
authors.lastname: Küpeli Akkol
mesh_terms: D000287:Administration, Topical; D000818:Animals; D008297:Male; D029777:Momordica charantia; D009061:Mouth Mucosa / Q000293:injuries*; D000069463:Olive Oil / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000069463:Olive Oil; D010936:Plant Extracts
keywords: Anti-inflammatory; Cucurbitaceae; Excision; Incision; Momordica charantia; Tensiometer; Wound healing