title: Compensatory Effect between Aortic Stiffening and Remodelling during Ageing.
abstract: The arterial tree exhibits a complex spatio-temporal wave pattern, whose healthy behaviour depends on a subtle balance between mechanical and geometrical properties. Several clinical studies demonstrated that such a balance progressively breaks down during ageing, when the aorta stiffens and remodels by increasing its diameter. These two degenerative processes however, have different impacts on the arterial wave pattern. They both tend to compensate for each other, thus reducing the detrimental effect they would have had if they had arisen individually. This remarkable compensatory mechanism is investigated by a validated multi-scale model, with the aim to elucidate how aortic stiffening and remodelling quantitatively impact the complex interplay between forward and reflected backward waves in the arterial network. We focus on the aorta and on the pressure at the ventricular-aortic interface, which epidemiological studies demonstrate to play a key role in cardiovascular diseases.
authors.affiliation: DIATI, Politecnico di Torino, Torino, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Guala
authors.affiliation: DIATI, Politecnico di Torino, Torino, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Camporeale
authors.affiliation: DIATI, Politecnico di Torino, Torino, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Ridolfi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001011:Aorta / Q000503:physiopathology*; D001783:Blood Flow Velocity; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D012307:Risk Factors; D055815:Young Adult