title: Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.
abstract: OBJECTIVE
  Evidence suggests that substance P (SP) is involved in chronic joint inflammation, such as the pathogenesis of rheumatoid arthritis and osteoarthritis. The goal of the research was to evaluate the correlation between chronic pain and changes in the SP level in patients with chronic inflammation of the connective tissue.
  
  
  METHODS
  Patients with osteoarthritis and rheumatoid arthritis were enrolled in this study. The relationship between chronic pain intensity and the serum SP concentration was evaluated in these groups of patients with osteoarthritis and rheumatoid arthritis.
  
  
  RESULTS
  The results showed a positive correlation between the serum SP concentrations and chronic pain intensity.
  
  
  CONCLUSIONS
  1. The SP serum concentration was significantly different between the groups of patients with OA and RA. 2. There was a positive correlation between the serum SP concentration and chronic pain intensity in OA and RA patients.
authors.affiliation: Department of Anaesthesiology, Medical Centre for Postgraduate Education, Adam Gruca Clinical Hospital, Postgraduate Medical Education Centre, Otwock, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Lisowska
authors.affiliation: Faculty of Production Engineering, Warsaw University of Life Sciences, Warsaw, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Lisowski
authors.affiliation: Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Siewruk
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000473:pathology; D059350:Chronic Pain / Q000378:metabolism* / Q000473:pathology; D003238:Connective Tissue / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism / Q000473:pathology; D013373:Substance P / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism / Q000502:physiology; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology
chemical_list: D013373:Substance P