title: Fluoxetine exposure during adolescence increases preference for cocaine in adulthood.
abstract: Currently, there is a high prevalence of antidepressant prescription rates within juvenile populations, yet little is known about the potential long-lasting consequences of such treatments, particularly on subsequent responses to drugs of abuse. To address this issue at the preclinical level, we examined whether adolescent exposure to fluoxetine (FLX), a selective serotonin reuptake inhibitor, results in changes to the sensitivity of the rewarding properties of cocaine in adulthood. Separate groups of male c57bl/6 mice were exposed to FLX (0 or 20 mg/kg) for 15 consecutive days either during adolescence (postnatal days [PD] 35-49) or adulthood (PD 65-79). Twenty-one days after FLX treatment, behavioral responsivity to cocaine (0, 2.5, 5, 10, or 20 mg/kg) conditioned place preference was assessed. Our data shows that mice pretreated with FLX during adolescence, but not during adulthood, display an enhanced dose-dependent preference to the environment paired with cocaine (5 or 10 mg/kg) when compared to age-matched saline pretreated controls. Taken together, our findings suggest that adolescent exposure to FLX increases sensitivity to the rewarding properties of cocaine, later in life.
authors.affiliation: Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA.|Department of Psychology, California State University, San Bernardino, CA, USA.
authors.forename: Sergio D
authors.initials: SD
authors.lastname: Iñiguez
authors.affiliation: Department of Psychology, California State University, San Bernardino, CA, USA.
authors.forename: Lace M
authors.initials: LM
authors.lastname: Riggs
authors.affiliation: Department of Psychology, California State University, San Bernardino, CA, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Nieto
authors.affiliation: Department of Biomedical Sciences, Florida State University, FL, USA.
authors.forename: Katherine N
authors.initials: KN
authors.lastname: Wright
authors.affiliation: Department of Psychology, California State University, San Bernardino, CA, USA.
authors.forename: Norma N
authors.initials: NN
authors.lastname: Zamora
authors.affiliation: Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Cruz
authors.affiliation: Department of Psychology, California State University, Long Beach, CA, USA.
authors.forename: Arturo R
authors.initials: AR
authors.lastname: Zavala
authors.affiliation: Department of Physiology, Michigan State University, Michigan, MI, USA.
authors.forename: Alfred J
authors.initials: AJ
authors.lastname: Robison
authors.affiliation: Department of Physiology, Michigan State University, Michigan, MI, USA.
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Mazei-Robison
mesh_terms: D000367:Age Factors; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005473:Fluoxetine / Q000494:pharmacology*; D005518:Food Preferences / Q000187:drug effects; D008297:Male; D008810:Mice, Inbred C57BL; D012201:Reward; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D013997:Time Factors
chemical_list: D003042:Cocaine; D018765:Dopamine Uptake Inhibitors; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors