title: Early Weight Loss as a Predictor of 2-Year Weight Loss and Resolution of Comorbidities After Sleeve Gastrectomy.
abstract: The objective of this study was to investigate whether early postoperative weight loss predicts weight loss 1 and 2 years after laparoscopic sleeve gastrectomy (LSG) and to determine its effect on the resolution of comorbidities.
  
  
  
  This was a prospective study of patients who underwent LSG at Jordan University Hospital from February 2009 to January 2014.
  
  
  
  One hundred ninety patients (mean age 34.0 ± 10.8 years; mean preoperative body mass index 46.2 ± 7.7 kg/m(2)) were included in the study. Of these, 146 were followed for 1 year and 73 were followed for 2 years. Thirty patients (20.5 %) had hypertension, 23 (15.8 %) had diabetes, 78 (53.4 %) had hyperlipidemia, 30 (20.5 %) had obstructive sleep apnea, and 50 (34.2 %) had more than one comorbidity. The percentage of excess weight loss (%EWL) was 22.7 ± 8.1, 75.1 ± 22.8, and 72.6 ± 17.5 at 1, 12, and 24 months, respectively. Fifty-five patients (37.7 %) had a 1-year %EWL of ≥80 %, and 29 (39.7 %) had a 2-year %EWL of ≥80 %. Linear regression analysis showed a strong correlation between 1-month %EWL and %EWL at 1 year (r (2) = 0.23, p < 0.001) and 2 years (r (2) = 0.28, p < 0.001). Resolution of comorbidities was associated with higher %EWL achieved at 1 year, but early postoperative weight loss did not have a significant effect on comorbidity resolution.
  
  
  
  Early postoperative weight loss can be used to identify and target poor responders.
authors.affiliation: Department of General Surgery, Faculty of Medicine, The University of Jordan, Amman, Jordan. fwfobeidat@gmail.com.|Minimally Invasive Gastrointestinal and Bariatric Surgery, Jordan University Hospital, Queen Rania St., P.O. Box 13046, Amman, 11942, Jordan. fwfobeidat@gmail.com.
authors.forename: Firas
authors.initials: F
authors.lastname: Obeidat
authors.affiliation: Department of General Surgery, Faculty of Medicine, The University of Jordan, Amman, Jordan.
authors.forename: Hiba
authors.initials: H
authors.lastname: Shanti
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D016014:Linear Models; D008297:Male; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome; D015431:Weight Loss
keywords: Bariatric surgery; Comorbidities; Early weight loss; Predictors; Sleeve gastrectomy