title: Moving Toward the Ground State.
abstract: Transferring mouse ESCs to a media supplemented with Mek and Gsk3β inhibitors (2i) provokes marked transcriptional and epigenetic changes, embodying a shift toward ground-state pluripotency. In this issue of Cell Stem Cell, Kolodziejczyk et al. (2015) examine population structures of ESCs while Galonska et al. (2015) unravel the mechanisms underlying regulatory network rewiring during 2i-mediated reprogramming.
authors.affiliation: Yale Stem Cell Center and Department of Genetics, Yale University, 10 Amistad Street, New Haven, CT 06520, USA.
authors.forename: Ishan
authors.initials: I
authors.lastname: Kumar
authors.affiliation: Yale Stem Cell Center and Department of Genetics, Yale University, 10 Amistad Street, New Haven, CT 06520, USA. Electronic address: natalia.ivanova@yale.edu.
authors.forename: Natalia
authors.initials: N
authors.lastname: Ivanova
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D000066450:Mouse Embryonic Stem Cells / Q000502:physiology*; D012313:RNA / Q000235:genetics*; D059467:Transcriptome
chemical_list: D012313:RNA