title: Association of a (TTTA)n microsatellite and a TCT del/ins polymorphisms in the aromatase gene (CYP19) with hip fracture risk in Mexican postmenopausal women.
abstract: A (TTTA)n polymorphism in the aromatase gene has been studied in relation to bone mineral density (BMD). The low number of TTTA repeats has been associated with low BMD and fracture risk. The aim of this study was to search for associations of TTTA copy number with hip fracture and lumbar spine osteoporosis in Mexican peri and postmenopausal women. The allele with seven repeats was present in the two reported versions, with or without a TCT deletion upstream of the microsatellite (A1 and A2, respectively). After adjustment by confounders, the A1 allele and the A1A1 genotype were significantly associated with an elevated risk of fracture (p = 0.034, OR = 3.2 [95% CI, 1.09-9.41] and p = 0.019, OR = 2.26 [95% CI, 1.14-4.49], respectively) and the A2 allele was associated with protection of hip fracture (p = 0.04, OR = 0.48, [95% CI, 0.22-1.05]) as the A2A2 genotype (p = 0.048, OR = 0.29 [95% CI, 0.06-1.16]). The analysis allowed us to defining the usefulness of the (TTTA)n polymorphism in the aromatase gene as an indicator of hip fracture risk in Mexican population.
authors.affiliation: a Dirección de Investigación, Genética, Instituto Nacional de Rehabilitación , México D.F. , México and.
authors.forename: Leonora
authors.initials: L
authors.lastname: Casas-Avila
authors.affiliation: a Dirección de Investigación, Genética, Instituto Nacional de Rehabilitación , México D.F. , México and.
authors.forename: Margarita
authors.initials: M
authors.lastname: Valdés-Flores
authors.affiliation: a Dirección de Investigación, Genética, Instituto Nacional de Rehabilitación , México D.F. , México and.
authors.forename: Antonio
authors.initials: A
authors.lastname: Miranda-Duarte
authors.affiliation: a Dirección de Investigación, Genética, Instituto Nacional de Rehabilitación , México D.F. , México and.
authors.forename: Valeria
authors.initials: V
authors.lastname: Ponce de León-Suárez
authors.affiliation: b Departmento de Medicina Genómica y Toxicología Ambiental , Instituto de Investigaciones Biomédicas, UNAM , México D.F. , México.
authors.forename: Clementina
authors.initials: C
authors.lastname: Castro-Hernández
authors.affiliation: b Departmento de Medicina Genómica y Toxicología Ambiental , Instituto de Investigaciones Biomédicas, UNAM , México D.F. , México.
authors.forename: Julieta
authors.initials: J
authors.lastname: Rubio-Lightbourn
authors.affiliation: a Dirección de Investigación, Genética, Instituto Nacional de Rehabilitación , México D.F. , México and.
authors.forename: Alberto
authors.initials: A
authors.lastname: Hidalgo-Bravo
mesh_terms: D000368:Aged; D000483:Alleles; D001141:Aromatase / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006620:Hip Fractures / Q000235:genetics*; D006801:Humans; D008159:Lumbar Vertebrae; D008800:Mexico; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics; D011110:Polymorphism, Genetic; D017698:Postmenopause
chemical_list: D001141:Aromatase
keywords: Aromatase polymorphisms; hip fracture; osteoporosis; postmenopausal women