title: Rapid and sensitive multiresidue analysis of pesticides in tobacco using low pressure and traditional gas chromatography tandem mass spectrometry.
abstract: Public exposure to pesticide residues through the main/side-stream smoke of tobacco (Nicotiana tabacum L.) is an international concern. This article reports optimization and validation of large-scale multiresidue analysis methods involving low pressure and traditional gas chromatography tandem mass spectrometry in compliance with the guidance residue levels (GRLs) of Cooperative Centre for Scientific Research Relative to Tobacco (CORESTA). Analysis by low pressure GC-MS/MS offered three times rapid turn around time over the traditional GC-MS/MS with limits of quantifications (LOQs) less than 2μg/L for all the 259 test compounds and the recoveries in the range of 70-118% (±20%) at 10 and 20μg/kg levels of fortification.
authors.affiliation: National Referral Laboratory, ICAR-National Research Centre for Grapes, P.O. Manjri Farm, Pune 412 307, India.
authors.forename: Zareen S
authors.initials: ZS
authors.lastname: Khan
authors.affiliation: National Referral Laboratory, ICAR-National Research Centre for Grapes, P.O. Manjri Farm, Pune 412 307, India.
authors.forename: Rushali
authors.initials: R
authors.lastname: Girame
authors.affiliation: National Referral Laboratory, ICAR-National Research Centre for Grapes, P.O. Manjri Farm, Pune 412 307, India.
authors.forename: Sagar C
authors.initials: SC
authors.lastname: Utture
authors.affiliation: ICAR-Central Tobacco Research Institute, Rajahmundry, Andhra Pradesh 533 105, India.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Ghosh
authors.affiliation: National Referral Laboratory, ICAR-National Research Centre for Grapes, P.O. Manjri Farm, Pune 412 307, India. Electronic address: kbgrape@yahoo.com.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Banerjee
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D010573:Pesticide Residues / Q000032:analysis*; D012906:Smoke / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000379:methods; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D010573:Pesticide Residues; D012906:Smoke
keywords: GC–MS/MS; Low pressure GC–MS/MS; Method validation; Multiresidue analysis of pesticides in tobacco