title: Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice.
abstract: OBJECTIVE
  Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice.
  
  
  METHODS
  Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus.
  
  
  RESULTS
  TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity.
  
  
  CONCLUSIONS
  The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior.
authors.affiliation: Technocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), India.
authors.forename: Raj
authors.initials: R
authors.lastname: Chanchal
authors.affiliation: Technocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), India.
authors.forename: Arumugam
authors.initials: A
authors.lastname: Balasubramaniam
authors.affiliation: Technocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), India.
authors.forename: Raj
authors.initials: R
authors.lastname: Navin
authors.affiliation: Technocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), India.
authors.forename: Sayyed
authors.initials: S
authors.lastname: Nadeem
keywords: Burying behavior; Fluoxetine; Tabernaemontana divaricata