title: In-situ Real-Time Monitoring of Volatile Organic Compound Exposure and Heart Rate Variability for Patients with Multiple Chemical Sensitivity.
abstract: In-situ real-time monitoring of volatile organic compound (VOC) exposure and heart rate variability (HRV) were conducted for eight multiple chemical sensitivity (MCS) patients using a VOC monitor, a Holter monitor, and a time-activity questionnaire for 24 h to identify the relationship between VOC exposure, biological effects, and subjective symptoms in actual life. The results revealed no significantly different parameters for averaged values such as VOC concentration, HF (high frequency), and LF (low frequency) to HF ratio compared with previous data from healthy subjects (Int. J. Environ. Res. Public Health 2010, 7, 4127-4138). Significant negative correlations for four subjects were observed between HF and amounts of VOC change. These results suggest that some patients show inhibition of parasympathetic activities along with VOC exposure as observed in healthy subjects. Comparing the parameters during subjective symptoms and normal condition, VOC concentration and/or VOC change were high except for one subject. HF values were low for five subjects during subjective symptoms. Examining the time-series data for VOC exposure and HF of each subject showed that the subjective symptoms, VOC exposure, and HF seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed.
authors.affiliation: Department of Environmental Medicine and Behavioral Science, Kinki University Faculty of Medicine, 377-2, Ohno-higashi, Osakasayama, Osaka 589-8511, Japan. mizukoshi@med.kindai.ac.jp.|Institute of Applied Brain Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan. mizukoshi@med.kindai.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizukoshi
authors.affiliation: Environmental Health Laboratory, California Department of Public Health, 850 Marina Bay Pkwy, Richmond, CA 94804, USA. kkumagai@cdph.ca.gov.
authors.forename: Kazukiyo
authors.initials: K
authors.lastname: Kumagai
authors.affiliation: Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea. nyamamoto@snu.ac.kr.
authors.forename: Naomichi
authors.initials: N
authors.lastname: Yamamoto
authors.affiliation: Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3-3-1 Kichijoji-kitamachi, Musashino, Tokyo 180-8633, Japan. noguchi@ejs.seikei.ac.jp.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Noguchi
authors.affiliation: Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan. kyoshiuc-tky@umin.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshiuchi
authors.affiliation: Institute of Applied Brain Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan. hikumano@waseda.jp.|Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan. hikumano@waseda.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kumano
authors.affiliation: Department of Anatomy and Cellular Biology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. sakabek@tokai-u.jp.
authors.forename: Kou
authors.initials: K
authors.lastname: Sakabe
authors.affiliation: The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8654, Japan. yukio@kaiseigakuen.jp.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yanagisawa
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis*; D015716:Electrocardiography, Ambulatory; D004784:Environmental Monitoring; D005260:Female; D006339:Heart Rate; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D018777:Multiple Chemical Sensitivity / Q000503:physiopathology*; D055549:Volatile Organic Compounds / Q000032:analysis*
chemical_list: D000393:Air Pollutants; D055549:Volatile Organic Compounds
keywords: HRV; MCS; VOC; real-time monitoring