title: Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice.
abstract: We explored the potential protective effects of tauroursodeoxycholic acid (TUDCA) on cone photoreceptor survival in a model of rapid retinal degeneration, the ß-Pde6 (rd1) (rd1) mouse model. We injected two strains of rd1 mice (B6.C3-Pde6b (rd1) Hps4(le)/J and C57BL/6J-Pde6b (rd1-2)/J mice) daily from postnatal day (P) 6 to P21 with TUDCA or vehicle. At P21, retinal function was evaluated with light-adapted electroretinography (ERG) and retinal structure was observed with plastic or frozen sections. TUDCA treatment partially preserved function and structure in B6.C3-Pde6b (rd1) Hps4(le)/J mice but only partially preserved structure in C57BL/6J-Pde6b (rd1-2)/J mice. Our results suggest a possible intervention for patients undergoing rapid retinal degeneration.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. eric.lawson90@gmail.com.|Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. eric.lawson90@gmail.com.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Lawson
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. shagun88@gmail.com.|Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. shagun88@gmail.com.
authors.forename: Shagun K
authors.initials: SK
authors.lastname: Bhatia
authors.affiliation: Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. moonkwon.han@gmail.com.
authors.forename: Moon K
authors.initials: MK
authors.lastname: Han
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. mhaung@emory.edu.|Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. mhaung@emory.edu.
authors.forename: Moe H
authors.initials: MH
authors.lastname: Aung
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. vciavat@emory.edu.|Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. vciavat@emory.edu.
authors.forename: Vincent
authors.initials: V
authors.lastname: Ciavatta
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. jboatri@emory.edu.
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Boatright
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. mpardue@emory.edu.|Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. mpardue@emory.edu.
authors.forename: Machelle T
authors.initials: MT
authors.lastname: Pardue
mesh_terms: D000818:Animals; D002452:Cell Count; D004195:Disease Models, Animal; D004596:Electroretinography; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D020419:Photoreceptor Cells, Vertebrate / Q000187:drug effects / Q000473:pathology; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D012174:Retinitis Pigmentosa / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D013045:Species Specificity; D013655:Taurochenodeoxycholic Acid / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D020011:Protective Agents; D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine
keywords: Bile acids; Retinal degeneration; Retinitis pigmentosa; TUDCA; Tauroursodeoxycholic acid; rd1 mice