title: Ciliary subcompartments and cysto-proteins.
abstract: Renal cystic diseases are conditions in which parts of or entire nephrons become enlarged and create fluid-filled cysts. These cysts occur in many genetic diseases. Most of the products of causative genes, termed cysto-proteins, are localized in cilia and/or centrioles. In addition, mutant mice lacking cilia develop renal cysts. Therefore, cilia are thought to have an important role in renal cystogenesis. The cilium is a tiny projection from the cell surface; however, it can be divided into several subcompartments. These subcompartments have specific roles. This review attempts to classify cysto-proteins based on their localization in ciliary subcompartments with the aim of defining relationships among them and of identifying their exact intraciliary functions.
authors.affiliation: Division of Developmental Biology, Department of Anatomy, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kawara-machi, Kamigyo-ku, Kyoto, 602-8566, Japan. tyoko@koto.kpu-m.ac.jp.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D002923:Cilia / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D052177:Kidney Diseases, Cystic / Q000378:metabolism*; D051379:Mice
keywords: Cilia; Ciliopathy; Inv compartment; Renal cyst; Transition zone