title: Application of IEUBK model in lead risk assessment of children aged 61-84 months old in central China.
abstract: Few studies have focused on the accuracy of using the Integrated Exposure Uptake Biokinetic (IEUBK) model in Chinese children with site- and age-specific exposure data. This study aimed to validate the accuracy and sensitivity of the IEUBK model in lead risk assessment of Chinese children aged 61-84 months old. A total of 760 children were enrolled from two respective counties in Central China by using random cluster sampling method. Blood lead levels (BLLs) of all subjects were determined using graphite furnace atomic absorption spectrometry, as well as that in the environmental media, such as air, drinking water, soil, dust and food. Age- and site-specific time-activity patterns and water consumption were evaluated by using questionnaires for children. Exposure parameters including outdoor and indoor activity time, ventilation rate and water consumption in this study were different from the default values of the IEUBK model. Statistical analysis revealed no significant differences between the predicted and observed BLLs. Diet and soil/dust lead intake contributed approximately 83.39% (57.40%-93.84% range) and 15.18% (3.25%-41.60% range) of total lead intake, respectively. These findings showed that the IEUBK model is suitable for lead risk assessment of Chinese children aged 61-84 months old and diet acts as an important lead source.
authors.affiliation: MOE Key Lab of Environment and Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Hu
authors.affiliation: MOE Key Lab of Environment and Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Liu
authors.affiliation: Hanyang Center for Disease Prevention and Control, Wuhan, Hubei, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: MOE Key Lab of Environment and Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
authors.forename: Na
authors.initials: N
authors.lastname: Yao
authors.affiliation: MOE Key Lab of Environment and Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
authors.forename: Linxiang
authors.initials: L
authors.lastname: Ye
authors.affiliation: MOE Key Lab of Environment and Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China. Electronic address: lwq95@126.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: MOE Key Lab of Environment and Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China. Electronic address: zhouyk@mails.tjmu.edu.cn.
authors.forename: Yikai
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D002675:Child, Preschool; D002681:China; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000032:analysis*; D004787:Environmental Pollution / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007854:Lead / Q000032:analysis*; D008297:Male; D008962:Models, Theoretical
chemical_list: D004785:Environmental Pollutants; D007854:Lead
keywords: Exposure parameters; Health risk assessment; Integrated exposure uptake biokinetic model; Lead; Source analysis