title: Synthesis of Tricyclic Spiranoid Lactones via I2/Sm(II)- and I2/Pd(0)-Mediated Cyclizations of a Common Cycloalkylmethylene Precursor.
abstract: A general synthesis of phylogenetically and structurally different tricyclic angularly fused spiranoid lactones, frequently observed as scaffold segments of various biochemical compounds and drugs of natural origin, is demonstrated via controlled cyclization of simple and easily accessible cycloalkylmethylene key precursors. The rapid composition of the key architecture yields an assembly of stable bicyclic iodolactones, which are converted to form a wide range of angularly fused tricyclic scaffolds.
authors.affiliation: The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem , Jerusalem 91120, Israel.
authors.forename: Yelena
authors.initials: Y
authors.lastname: Mostinski
authors.affiliation: The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem , Jerusalem 91120, Israel.
authors.forename: Viviana
authors.initials: V
authors.lastname: Valerio
authors.affiliation: The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem , Jerusalem 91120, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Lankri
authors.affiliation: The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem , Jerusalem 91120, Israel.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Tsvelikhovsky