title: Review: Effect study of sex hormone in the multiple sclerosis of common neurological disorders.
abstract: Multiple sclerosis (MS) is one of most common neurological disorders, mainly affecting women. The central nervous system (CNS) of this autoimmune disease is characterized by intermittent or chronic damage to the myelin sheaths (demyelination), local inflammation and axonal degeneration. During the early relapsing/remitting stages of MS, myelin can regenerate. However, as the disease progresses, both amount and activity of regenerated axons becomes insufficient, leading to impaired axon conduction, neurodegeneration and the worsening symptoms. Epidemiological study found that distinct symptom alleviation of diseases at a certain periods would be shown in women during pregnancy. The following basic researches indicated that sex hormones especially progesterone can significantly reduce the disease severity, moreover, the protective effect of sex hormone on the nervous system has become the research focus.
authors.affiliation: Maternal and Child Health Hospital of Zhengzhou City, Zhengzhou City, Henan Province, PR China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Xin
authors.forename: Dayong
authors.initials: D
authors.lastname: Xu
authors.affiliation: Maternal and Child Health Hospital of Zhengzhou City, Zhengzhou City, Henan Province, PR China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Yang
authors.affiliation: Maternal and Child Health Hospital of Zhengzhou City, Zhengzhou City, Henan Province, PR China.
authors.forename: Aizhen
authors.initials: A
authors.lastname: Liu
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Maternal and Child Health Hospital of Zhengzhou City, Zhengzhou City, Henan Province, PR China.
authors.forename: Baozhi
authors.initials: B
authors.lastname: Guo
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000627:therapeutic use*; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D009416:Nerve Regeneration
chemical_list: D012739:Gonadal Steroid Hormones