title: Adaptive regulation of glucose transport, glycolysis and respiration for cell proliferation.
abstract: The cell must utilise nutrients to generate energy as a means of sustaining its life. As the environment is not necessarily abundant in nutrients and oxygen, the cell must be able to regulate energy metabolism to adapt to changes in extracellular and intracellular conditions. Recently, several key regulators of energy metabolism have been reported. This review describes the recent advances in molecular regulation of energy metabolism, focusing mainly on glycolysis and its shunt pathways. Human diseases, such as cancer and neurodegenerative disorders, are also discussed in relation to failure of energy metabolism regulation.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Toyoda
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Saitoh
mesh_terms: D001692:Biological Transport; D049109:Cell Proliferation / Q000502:physiology*; D019069:Cell Respiration / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism
chemical_list: D005947:Glucose