title: Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review.
abstract: DNA methylation, a process of adding a methyl group to DNA done by a DNA methyltransferase is a heritable (epigenetic) alteration leading to cancer, atherosclerosis, nervous disorders (Imprinting disorders), and cardiovascular diseases. The role of nutrition in DNA methylation is revealed by identification of methyl variable positions (MVP) on DNA. These regions are more susceptible to DNA methylations. Nutritional supplementation of folic acid and methionine in utero and in adults decreased epigenetic modifications due to its role in DNA metabolism (one carbon metabolism). Thus, in utero and adult supplementation of folic acid and methionine may reduce DNA methylation. This review attempts to highlight the process of DNA methylation, its effect on various diseases, and the probable protective role of nutrition.
authors.affiliation: Department of Microbiology, Prathima Institute of Medical Sciences.
authors.forename: Venkataramana
authors.initials: V
authors.lastname: Kandi
authors.affiliation: Biochemistry, Chalmeda Anand Rao Institute of Medical Sciences.
authors.forename: Sabitha
authors.initials: S
authors.lastname: Vadakedath
keywords: dna methylation; epigenetic modifications; imprinting disorders; methyltransferase