title: Lack of CD151/integrin α3β1 complex is predictive of poor outcome in node-negative lobular breast carcinoma: opposing roles of CD151 in invasive lobular and ductal breast cancers.
abstract: BACKGROUND
  The proposed involvement of CD151 in breast cancer (BCa) progression is based on findings from studies in invasive ductal carcinoma (IDC). The IDC and invasive lobular carcinoma (ILC) represent distinct disease entities. Here we evaluated clinical significance of CD151 alone and in association with integrin α3β1 in patients with ILC in context of the data of our recent IDC study.
  
  
  METHODS
  Expression of CD151 and/or integrin α3β1 was evaluated in ILC samples (N=117) using immunohistochemistry. The findings were analysed in relation to our results from an IDC cohort (N=182) demonstrating a prognostic value of an expression of CD151/integrin α3β1 complex in patients with HER2-negative tumours.
  
  
  RESULTS
  Unlike in the IDCs, neither CD151 nor CD151/α3β1 complex showed any correlation with any of the ILC characteristics. Lack of both CD151 and α3β1 was significantly correlated with poor survival (P=0.034) in lymph node-negative ILC N(-) cases. The CD151(-)/α3β1(-) patients had 3.12-fold higher risk of death from BCa in comparison with the rest of the ILC N(-) patients.
  
  
  CONCLUSIONS
  Biological role of CD151/α3β1 varies between ILC and IDC. Assessment of CD151/α3β1 might help to identify ILC N(-) patients with increased risk of distant metastases.
authors.affiliation: Department of Pathology, Medical University of Łódź, ul. Pomorska 251, 92-213 Łódź, Poland.
authors.forename: Hanna M
authors.initials: HM
authors.lastname: Romanska
authors.affiliation: Department of Chemotherapy, Medical University of Łódź and M. Kopernik Memorial Hospital, ul. Paderewskiego 4, 93-509 Łódź, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Potemski
authors.affiliation: Department of Chemotherapy, Medical University of Łódź and M. Kopernik Memorial Hospital, ul. Paderewskiego 4, 93-509 Łódź, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Krakowska
authors.affiliation: Department of Molecular Enzymology, Intercollegiate Faculty of Biotechnology, Medical University of Gdańsk, ul. Dębinki 1, 80-210 Gdansk, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Mieszkowska
authors.affiliation: Department of Cellular Pathology, University of Birmingham, Birmingham, UK.
authors.forename: Shalini
authors.initials: S
authors.lastname: Chaudhri
authors.affiliation: Department of Pathology, Medical University of Łódź, ul. Pomorska 251, 92-213 Łódź, Poland.
authors.forename: Radzisław
authors.initials: R
authors.lastname: Kordek
authors.affiliation: Department of Pathology, Medical University of Łódź, ul. Pomorska 251, 92-213 Łódź, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Kubiak
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK.
authors.forename: Valerie
authors.initials: V
authors.lastname: Speirs
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Hanby
authors.affiliation: Department of Molecular Enzymology, Intercollegiate Faculty of Biotechnology, Medical University of Gdańsk, ul. Dębinki 1, 80-210 Gdansk, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Sadej
authors.affiliation: School of Cancer Sciences of the University of Birmingham, Birmingham B15 2TT, UK.
authors.forename: Fedor
authors.initials: F
authors.lastname: Berditchevski
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D039201:Integrin alpha3beta1 / Q000378:metabolism*; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D060185:Tetraspanin 24 / Q000378:metabolism*
chemical_list: D039201:Integrin alpha3beta1; D018719:Erb-b2 Receptor Tyrosine Kinases; D060185:Tetraspanin 24; C508053:ERBB2 protein, human