title: Effects of vitamin D supplementation as an adjuvant therapy in coronary artery disease patients.
abstract: OBJECTIVE
  Low vitamin D status has been shown to be associated with coronary artery disease. We planned to research the effects of vitamin D3 supplementation on the severity of coronary artery disease.
  
  
  METHODS
  We investigated the effect of 0.5 μg vitamin D3 per day in a randomized, placebo-controlled, double-blind study in 90 stable coronary artery disease patients residing in Beijing. Coronary angiography was performed before and after 6 months of treatment that took place between January and June. 25-Hydroxyvitamin D was measured by chemiluminescence assay. Coronary artery disease severity was assessed by using the SYNTAX scores.
  
  
  RESULTS
  In vitamin D supplementation group, there was a significant increase in mean 25-hydroxyvitamin D levels from baseline (19.9 ± 9.8 ng/ml) to 6 months (35.8 ± 12.1 ng/ml; p < 0.001). At 6 months, the primary end point, a difference in the fall of SYNTAX score between the groups was -2.5 (95% CI -5.1 to -0.5; p < 0.001) under intention to treat analysis. Compared with the control group, patients treated with vitamin D3 also had greater decreases in high sensitivity C-reactive protein and renin-angiotensin system activity (p < 0.05).
  
  
  CONCLUSIONS
  Vitamin D supplementation has beneficial effects on coronary artery disease; it can be an adjuvant therapy for patients with coronary artery disease.
authors.affiliation: a Department of Gerontology , The Second Affiliated Hospital of Zhengzhou University at Zhengzhou , Zhengzhou , China.
authors.forename: Zhaoke
authors.initials: Z
authors.lastname: Wu
authors.affiliation: b Department of Gerontology , Shanxi Provincial People's Hospital at Xi'an , Xi'an , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: a Department of Gerontology , The Second Affiliated Hospital of Zhengzhou University at Zhengzhou , Zhengzhou , China.
authors.forename: Shenshen
authors.initials: S
authors.lastname: Zhu
authors.affiliation: c Department of Cardiology , The First Affiliated Hospital of Zhengzhou University at Zhengzhou , Zhengzhou , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002681:China; D002762:Cholecalciferol / Q000627:therapeutic use*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D057194:Intention to Treat Analysis; D008297:Male; D008875:Middle Aged; D012084:Renin-Angiotensin System; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D015415:Biomarkers; D014807:Vitamin D; D002762:Cholecalciferol; D002097:C-Reactive Protein; C104450:25-hydroxyvitamin D
keywords: Adjuvant therapy; SYNTAX scores; coronary artery disease; supplementation; vitamin D