title: The importance of age and menopausal status in endometrial complex hyperplasia with atypia.
abstract: The effects of menopausal status and age on the intra-operative and post-operative pathology results of patients operated on with a pre-operative diagnosis of complex hyperplasia with atypia (CHA) were assessed. A hundred and eleven patients diagnosed in our centre between January 1993 and March 2013 were included. Cancer was detected in the paraffin blocks (PBs) of 52 (46.8%) patients. Among these, 50 patients had stage-IA disease. In 31.1% of the pre-menopausal patients and 66% of the post-menopausal patients, PB revealed cancer (p < 0.0001). The results of frozen section (FS) and PB were concordant in 51% and 70% in the pre-menopausal and post-menopausal patients, respectively (p = 0.041). In the patients operated on with a pre-operative diagnosis of CHA, the probability of detecting cancer in PB increases with increasing age and menopause. The reliability of FS is limited in younger and pre-menopausal patients.
authors.affiliation: a EtlikZubeydeHanim Women's Health Teaching and Research Hospital, Gynecologic Oncology Division , Kecioren, Ankara , Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Ureyen
authors.affiliation: a EtlikZubeydeHanim Women's Health Teaching and Research Hospital, Gynecologic Oncology Division , Kecioren, Ankara , Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Karalok
authors.affiliation: a EtlikZubeydeHanim Women's Health Teaching and Research Hospital, Gynecologic Oncology Division , Kecioren, Ankara , Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Tasci
authors.affiliation: a EtlikZubeydeHanim Women's Health Teaching and Research Hospital, Gynecologic Oncology Division , Kecioren, Ankara , Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Turkmen
authors.affiliation: a EtlikZubeydeHanim Women's Health Teaching and Research Hospital, Gynecologic Oncology Division , Kecioren, Ankara , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Koc
authors.affiliation: a EtlikZubeydeHanim Women's Health Teaching and Research Hospital, Gynecologic Oncology Division , Kecioren, Ankara , Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ozgul
authors.affiliation: a EtlikZubeydeHanim Women's Health Teaching and Research Hospital, Gynecologic Oncology Division , Kecioren, Ankara , Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Tulunay
authors.affiliation: a EtlikZubeydeHanim Women's Health Teaching and Research Hospital, Gynecologic Oncology Division , Kecioren, Ankara , Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Turan
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D004714:Endometrial Hyperplasia / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D005629:Frozen Sections; D006801:Humans; D008875:Middle Aged; D016612:Paraffin Embedding; D017698:Postmenopause; D017697:Premenopause
keywords: Age; endometrial cancer; endometrial complex hyperplasia with atypia; frozen section; menopausal status