title: Targeted drug delivery to the brain using magnetic nanoparticles.
abstract: Brain capillary endothelial cells denote the blood-brain barrier (BBB), and conjugation of nanoparticles with antibodies that target molecules expressed by these endothelial cells may facilitate their uptake and transport into the brain. Magnetic nanoparticles can be encapsulated in liposomes and carry large molecules with therapeutic potential, for example, siRNA, cDNA and polypeptides. An additional approach to enhance the transport of magnetic nanoparticles across the BBB is the application of extracranially applied magnetic force. Stepwise targeting of magnetic nanoparticles to brain capillary endothelial cells followed by transport through the BBB using magnetic force may prove a novel mechanism for targeted therapy of macromolecules to the brain.
authors.affiliation: Laboratory of Neurobiology, Section of Biomedicine, Department of Health Science & Technology, Aalborg University, Fredrik Bajers Vej 3 B, 9220 Aalborg East, Denmark.
authors.forename: Louiza Bohn
authors.initials: LB
authors.lastname: Thomsen
authors.affiliation: Laboratory of Neurobiology, Section of Biomedicine, Department of Health Science & Technology, Aalborg University, Fredrik Bajers Vej 3 B, 9220 Aalborg East, Denmark.
authors.forename: Maj Schneider
authors.initials: MS
authors.lastname: Thomsen
authors.affiliation: Laboratory of Neurobiology, Section of Biomedicine, Department of Health Science & Technology, Aalborg University, Fredrik Bajers Vej 3 B, 9220 Aalborg East, Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Moos
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*
chemical_list: D058185:Magnetite Nanoparticles