title: Drug-induced skin toxicity and clinical nursing of VitK cream on colorectal cancer patients.
abstract: To discuss the impact of 0.1% vitamin K1 (VitK1) cream on cetuximab-induced skin toxicity for colorectal cancer patients. 60 colorectal cancer patients with cetuximab therapy after hospitalization, were divided into experimental group (Ward A) and control group (Ward B) according to personnel sequential number, with 30 cases in each group. Routine nursing was implemented on control group. For experimental group, on the routine nursing basis, 0.1% VitK1 cream was smeared on face, neck, chest, back and nail (toenail) edge with three times one day at the application of cetuximab day. After cetuximab applied in 8 weeks, both skin itch and dry skin for patients in experimental group were significantly improved compared those in control group, showing statistically significant difference (W=708.000, P=0.001: W=662. 500, P=0.000). 0.1% VitK1 cream was conducive to improve both skin itch and dry skin symptoms in the cetuximab-induced skin toxicity for colorectal cancer patients.
authors.affiliation: Medical Oncology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Li
authors.affiliation: Nursing Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China.
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Miao
authors.affiliation: Medical Oncology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Medical Oncology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China.
authors.forename: Yao-Zhen
authors.initials: YZ
authors.lastname: Ma
authors.affiliation: Medical Oncology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China.
authors.forename: Zhen-Chang
authors.initials: ZC
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000068818:Cetuximab; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000188:drug therapy*; D010837:Vitamin K 1 / Q000627:therapeutic use*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D009824:Ointments; D010837:Vitamin K 1; D000068818:Cetuximab