title: Preclinical combination of TP-0903, an AXL inhibitor and B-PAC-1, a procaspase-activating compound with ibrutinib in chronic lymphocytic leukemia.
authors.affiliation: a Department of Experimental Therapeutics , The University of Texas MD Anderson Cancer Center , Houston , TX , USA ;
authors.forename: Viralkumar
authors.initials: V
authors.lastname: Patel
authors.affiliation: b Department of Leukemia , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Keating
authors.affiliation: b Department of Leukemia , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors.forename: William G
authors.initials: WG
authors.lastname: Wierda
authors.affiliation: a Department of Experimental Therapeutics , The University of Texas MD Anderson Cancer Center , Houston , TX , USA ;|b Department of Leukemia , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors.forename: Varsha
authors.initials: V
authors.lastname: Gandhi
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives; D000970:Antineoplastic Agents / Q000494:pharmacology*; D020169:Caspases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006801:Humans; D006835:Hydrazones / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000378:metabolism*; D010879:Piperazines / Q000494:pharmacology*; D010880:Piperidines; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors*; D011720:Pyrazoles / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D013449:Sulfonamides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000094963:Axl Receptor Tyrosine Kinase; D000096926:Benzenesulfonamides
chemical_list: D000225:Adenine; D000970:Antineoplastic Agents; D020169:Caspases; D006835:Hydrazones; D010879:Piperazines; D010880:Piperidines; D011518:Proto-Oncogene Proteins; D011720:Pyrazoles; D011743:Pyrimidines; D020794:Receptor Protein-Tyrosine Kinases; D013449:Sulfonamides; D000094963:Axl Receptor Tyrosine Kinase; C000597017:2-(4-(4-(benzyloxy)benzyl)piperazin-1-yl)-N'-(3,5-di-tert-butyl-2-hydroxybenzylidene)acetohydrazide; C000606144:dubermatinib; D000096926:Benzenesulfonamides; C551803:ibrutinib; C000722289:AXL protein, human