title: The Choice of Hemodialysis Membrane Affects Bisphenol A Levels in Blood.
abstract: Bisphenol A (BPA), a component of some dialysis membranes, accumulates in CKD. Observational studies have linked BPA exposure to kidney and cardiovascular injury in humans, and animal studies have described a causative link. Normal kidneys rapidly excrete BPA, but insufficient excretion may sensitize patients with CKD to adverse the effects of BPA. Using a crossover design, we studied the effect of dialysis with BPA-containing polysulfone or BPA-free polynephron dialyzers on BPA levels in 69 prevalent patients on hemodialysis: 28 patients started on polysulfone dialyzers and were switched to polynephron dialyzers; 41 patients started on polynephron dialyzers and were switched to polysulfone dialyzers. Results were grouped for analysis. Mean BPA levels increased after one hemodialysis session with polysulfone dialyzers but not with polynephron dialyzers. Chronic (3-month) use of polysulfone dialyzers did not significantly increase predialysis serum BPA levels, although a trend toward increase was detected (from 48.8±6.8 to 69.1±10.1 ng/ml). Chronic use of polynephron dialyzers reduced predialysis serum BPA (from 70.6±8.4 to 47.1±7.5 ng/ml, P<0.05). Intracellular BPA in PBMCs increased after chronic hemodialysis with polysulfone dialyzers (from 0.039±0.002 to 0.043±0.001 ng/10(6) cells, P<0.01), but decreased with polynephron dialyzers (from 0.045±0.001 to 0.036±0.001 ng/10(6) cells, P<0.01). Furthermore, chronic hemodialysis with polysulfone dialyzers increased oxidative stress in PBMCs and inflammatory marker concentrations in circulation. In vitro, polysulfone membranes released significantly more BPA into the culture medium and induced more cytokine production in cultured PBMCs than did polynephron membranes. In conclusion, dialyzer BPA content may contribute to BPA burden in patients on hemodialysis.
authors.affiliation: Renal, Vascular and Diabetes Laboratory, and.
authors.forename: Enrique
authors.initials: E
authors.lastname: Bosch-Panadero
authors.affiliation: Renal, Vascular and Diabetes Laboratory, and Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; smas@fjd.es.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Mas
authors.affiliation: Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain;
authors.forename: Didier
authors.initials: D
authors.lastname: Sanchez-Ospina
authors.affiliation: Division of Nephrology, Hospital Universitario de Burgos, Burgos, Spain;
authors.forename: Vanesa
authors.initials: V
authors.lastname: Camarero
authors.affiliation: Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain; Red Española de Investigación Renal, Madrid, Spain;
authors.forename: Maria V
authors.initials: MV
authors.lastname: Pérez-Gómez
authors.affiliation: Division of Nephrology, Hospital Universitario de Burgos, Burgos, Spain;
authors.forename: Isabel
authors.initials: I
authors.lastname: Saez-Calero
authors.affiliation: Division of Nephrology, Hospital Universitario de Burgos, Burgos, Spain;
authors.forename: Pedro
authors.initials: P
authors.lastname: Abaigar
authors.affiliation: Renal, Vascular and Diabetes Laboratory, and Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain; Red Española de Investigación Renal, Madrid, Spain; Department of Medicine, UAM Medical School, Madrid, Spain; and Fundación Renal Íñigo Álvarez de Toledo/Instituto Reina Sofía de Investigación en Nefrología, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz
authors.affiliation: Renal, Vascular and Diabetes Laboratory, and Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain; Department of Medicine, UAM Medical School, Madrid, Spain; and Fundación Renal Íñigo Álvarez de Toledo/Instituto Reina Sofía de Investigación en Nefrología, Madrid, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Egido
authors.affiliation: Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain; Red Española de Investigación Renal, Madrid, Spain; Department of Medicine, UAM Medical School, Madrid, Spain; and Fundación Renal Íñigo Álvarez de Toledo/Instituto Reina Sofía de Investigación en Nefrología, Madrid, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: González-Parra
mesh_terms: D000368:Aged; D001559:Benzhydryl Compounds / Q000097:blood*; D001672:Biocompatible Materials; D018592:Cross-Over Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008567:Membranes, Artificial; D010636:Phenols / Q000097:blood*; D011108:Polymers; D011446:Prospective Studies; D006435:Renal Dialysis; D013450:Sulfones; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D010636:Phenols; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: ESRD; hemodialysis; oxidative stress