title: EBNA2 and Its Coactivator EBNA-LP.
abstract: While all herpesviruses can switch between lytic and latent life cycle, which are both driven by specific transcription programs, a unique feature of latent EBV infection is the expression of several distinct and well-defined viral latent transcription programs called latency I, II, and III. Growth transformation of B-cells by EBV in vitro is based on the concerted action of Epstein-Barr virus nuclear antigens (EBNAs) and latent membrane proteins(LMPs). EBV growth-transformed B-cells express a viral transcriptional program, termed latency III, which is characterized by the coexpression of EBNA2 and EBNA-LP with EBNA1, EBNA3A, -3B, and -3C as well as LMP1, LMP2A, and LMP2B. The focus of this review will be to discuss the current understanding of how two of these proteins, EBNA2 and EBNA-LP, contribute to EBV-mediated B-cell growth transformation.
authors.affiliation: Department of Gene Vectors, Helmholtz Center Munich, German Research Center for Environmental Health, Marchioninistr. 25, 81377, Munich, Germany. kempkes@helmholtz-muenchen.de.
authors.forename: Bettina
authors.initials: B
authors.lastname: Kempkes
authors.affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA. pling@bcm.edu.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Ling
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000821:virology; D002472:Cell Transformation, Viral; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics / Q000378:metabolism*; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C402641:EBNA-2 protein, Human herpesvirus 4; C402640:EBNA-LP protein, Human herpesvirus 4; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins
keywords: CBF1; EBNA2; EBNA‐LP; Target genes; Transactivation