title: Sargaquinoic Acid Inhibits TNF-α-Induced NF-κB Signaling, Thereby Contributing to Decreased Monocyte Adhesion to Human Umbilical Vein Endothelial Cells (HUVECs).
abstract: Sargaquinoic acid (SQA) has been known for its antioxidant and anti-inflammatory properties. This study investigated the effects of SQA isolated from Sargassum serratifolium on the inhibition of tumor necrosis factor (TNF)-α-induced monocyte adhesion to human umbilical vein endothelial cells (HUVECs). SQA decreased the expression of cell adhesion molecules such as intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 as well as chemotactic cytokines such as interleukin-8 and monocyte chemoattractant protein-1 in TNF-α-treated HUVECs. As a result, SQA prevented monocyte adhesion to TNF-α-induced adhesion. SQA also inhibited TNF-α-induced nuclear factor kappa B (NF-κB) translocation into the nucleus by preventing proteolytic degradation of inhibitor κB-α. Overall, SQA protects against TNF-α-induced vascular inflammation through inhibition of the NF-κB pathway in HUVECs. These data suggest that SQA may be used as a therapeutic agent for vascular inflammatory diseases such as atherosclerosis.
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University , Busan 608-737, South Korea.
authors.forename: Wi-Gyeong
authors.initials: WG
authors.lastname: Gwon
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University , Busan 608-737, South Korea.
authors.forename: Bonggi
authors.initials: B
authors.lastname: Lee
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University , Busan 608-737, South Korea.
authors.forename: Eun-Ji
authors.initials: EJ
authors.lastname: Joung
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University , Busan 608-737, South Korea.
authors.forename: Min-Woo
authors.initials: MW
authors.lastname: Choi
authors.affiliation: Food and Safety Research Division, National Fisheries Research and Development Institute , Gijang-gun, Busan 619-705, South Korea.
authors.forename: Nayoung
authors.initials: N
authors.lastname: Yoon
authors.affiliation: Division of Food and Nutrition, Chonnam National University , Buk-gu, Gwangju 500-757, South Korea.
authors.forename: Taisun
authors.initials: T
authors.lastname: Shin
authors.affiliation: Department of Marine Biology, Pukyong National University , Busan 608-737, South Korea.
authors.forename: Chul-Woong
authors.initials: CW
authors.lastname: Oh
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University , Busan 608-737, South Korea.
authors.forename: Hyeung-Rak
authors.initials: HR
authors.lastname: Kim
mesh_terms: D000475:Alkenes / Q000494:pharmacology*; D016227:Benzoquinones / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D009000:Monocytes / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D044647:Sargassum / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D000475:Alkenes; D016227:Benzoquinones; D016328:NF-kappa B; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; C477718:sargaquinoic acid; D018799:Intercellular Adhesion Molecule-1
keywords: adhesion molecule; anti-inflammation; human umbilical vein endothelial cell; nuclear factor-κB; sargaquinoic acid