title: [Comparison of propofol and midazolam on patients undergoing spinal surgery with intraoperative wake-up test: randomized clinical trial].
abstract: OBJECTIVE
  Instrumentation in correction operations for spinal deformities carries a 0.5-5% risk of injuring the spinal cord. The wake-up test is used for early detection of these injuries. In this study we compared the effects of propofol and midazolam during wake-up test in scoliosis surgery.
  
  
  METHODS
  Thirty patients were randomly assigned as group P and group M. Anesthesia was induced with propofol 2.5mgkg(-1) for group P or midazolam 0.5mgkg(-1) for group M with remifentanil 0.5μgkg(-1) and cisatracurium 0.15mgkg(-1) for both groups. At the maintenance of anesthesia O2/air and infusions of remifentanil and cisatracurium were used. In group P, propofol 6-10mgkg(-1)h(-1) and in group M, midazolam 0.5mgmgkg(-1) were preferred. Approximately 15min before the wake-up test, all drugs were discontinued. At the wake-up test, anesthesiologist asked the patients to open their eyes and squeeze his/her hand at every 30s until the patients responded. Then patients were told to wiggle their toes. Hemodynamic parameters, time of eye-opening, appropriate movement upon verbal command were evaluated. BIS frequency throughout the operation was recorded.
  
  
  RESULTS
  The eye opening time was 9±2.15min in group P and 7±3.15min in group M. Motor movement time was 12±2.55min in group P and 21.25±3.93min in group M.
  
  
  CONCLUSIONS
  Propofol provided better wake-up conditions and conducted a better neurologic assessment within the same BIS values than midazolam.
authors.affiliation: Departamento de Anestesiologia e Reanimação, Faculdade de Medicina da Universidade Hacettepe, Ancara, Turquia.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Canbay
authors.affiliation: Hospital Estadual de Biga, Biga, Canakkale, Turquia. Electronic address: basakugurlu@me.com.
authors.forename: Basak
authors.initials: B
authors.lastname: Altiparmak
authors.affiliation: Departamento de Anestesiologia e Reanimação, Faculdade de Medicina da Universidade Hacettepe, Ancara, Turquia.
authors.forename: Nalan
authors.initials: N
authors.lastname: Celebi
authors.affiliation: Departamento de Anestesiologia e Reanimação, Faculdade de Medicina da Universidade Hacettepe, Ancara, Turquia.
authors.forename: Heves
authors.initials: H
authors.lastname: Karagoz
authors.affiliation: Departamento de Anestesiologia e Reanimação, Faculdade de Medicina da Universidade Hacettepe, Ancara, Turquia.
authors.forename: Fatma
authors.initials: F
authors.lastname: Saricaoglu
keywords: BIS; Cirurgia de coluna; Midazolam; Propofol; Spine surgery; Teste de despertar; Wake‐up test