title: Falls and Depression in Men: A Population-Based Study.
abstract: The link between falls and depression has been researched in the elderly; however, little information is available on this association in younger adults, particularly men. This study sought to investigate the link between major depressive disorder (MDD) and falls in a population-based sample of 952 men (24-97 years). MDD was diagnosed utilizing the Structured Clinical Interview for DSM-IV-TR Research Version, Non-Patient edition, and categorized as 12-month/past/never. Body mass index and gait were measured; falls, smoking status, psychotropic medication use, and alcohol intake were self-reported as part of the Geelong Osteoporosis Study 5-year follow-up assessment. Thirty-four (3.6%) men met criteria for 12-month MDD, and 110 (11.6%) for past MDD. Of the 952 men, 175 (18.4%) reported falling at least once during the past 12 months. Fallers were older (66 [interquartile range: 48-79] vs. 59 [45-72] years, p = .001) and more likely to have uneven gait ( n = 16, 10% vs. n = 31, 4%, p = .003) than nonfallers. Participants with 12-month MDD had more than twice the odds of falling (age-adjusted odds ratio: 2.22, 95% confidence interval [1.03, 4.80]). The odds of falling were not associated with past depression ( p = .4). Further adjustments for psychotropic drug use, gait, body mass index, smoking status, blood pressure, and alcohol did not explain these associations. Given the 2.2-fold greater likelihood of falling associated with depression was not explained by age or psychotropic drug use, further research is warranted.
authors.affiliation: 1 IMPACT Strategic Research Centre, Deakin University, Geelong, Victoria, Australia.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Stuart
authors.affiliation: 1 IMPACT Strategic Research Centre, Deakin University, Geelong, Victoria, Australia.|2 The University of Melbourne, Victoria, Australia.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Pasco
authors.affiliation: 1 IMPACT Strategic Research Centre, Deakin University, Geelong, Victoria, Australia.|2 The University of Melbourne, Victoria, Australia.|3 Murdoch Children's Research Institute, Sydney, New South Wales, Australia.|4 Black Dog Institute, Sydney, New South Wales, Australia.
authors.forename: Felice N
authors.initials: FN
authors.lastname: Jacka
authors.affiliation: 1 IMPACT Strategic Research Centre, Deakin University, Geelong, Victoria, Australia.|2 The University of Melbourne, Victoria, Australia.|5 Orygen, Parkville, Victoria, Australia.|6 Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
authors.affiliation: 1 IMPACT Strategic Research Centre, Deakin University, Geelong, Victoria, Australia.
authors.forename: Lana J
authors.initials: LJ
authors.lastname: Williams
mesh_terms: D000058:Accidental Falls / Q000706:statistics & numerical data*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001315:Australia; D015331:Cohort Studies; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents
keywords: SCID-1/NP; depression; falls; osteoporosis; psychotropic medication