title: Calcification of MC3T3-E1 cells on titanium and zirconium.
abstract: To confirm similarity of hard tissue compatibility between titanium and zirconium, calcification of MC3T3-E1 cells on titanium and zirconium was evaluated in this study. Mirror-polished titanium (Ti) and zirconium (Zr) disks and zirconium-sputter deposited titanium (Zr/Ti) were employed in this study. The surface of specimens were characterized using scanning electron microscopy and X-ray diffraction. Then, the cellular proliferation, differentiation and calcification of MC3T3-E1 cells on specimens were investigated. The surface of Zr/Ti was much smoother and cleaner than those of Ti and Zr. The proliferation of the cell was the same among three specimens, while the differentiation and calcification on Zr/Ti were faster than those on Ti and Zr. Therefore, Ti and Zr showed the identical hard tissue compatibility according to the evaluation with MC3T3-E1 cells. Sputter deposition may improve cytocompatibility.
authors.affiliation: Department of Maxillofacial Orthognathics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Umezawa
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Doi
authors.forename: Maki
authors.initials: M
authors.lastname: Ashida
authors.forename: Shoichi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Keiji
authors.initials: K
authors.lastname: Moriyama
authors.forename: Takao
authors.initials: T
authors.lastname: Hanawa
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002113:Calcification, Physiologic / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects; D014025:Titanium / Q000494:pharmacology*; D015040:Zirconium / Q000494:pharmacology*
chemical_list: D015040:Zirconium; D014025:Titanium