title: [Predictors of atrial fibrillation recurrence after catheter ablation in hypertrophic cardiomyopathy patients with atrial fibrillation].
abstract: OBJECTIVE
  To evaluate the efficacy of catheter ablation in Chinese hypertrophic cardiomyopathy (HCM) patients with atrial fibrillation (AF), and to determine the risk factors of AF recurrence.
  
  
  METHODS
  This study enrolled 40 HCM patients with AF who underwent primary AF ablation at Beijing Anzhen Hospital from June 2005 to June 2013. Ablation strategy included bilateral pulmonary vein isolation (PVI) for paroxysmal AF (n = 27) and PVI plus left atrial roof, mitral isthmus and tricuspid isthmus linear ablations for persistent AF (n = 13). AF recurrence was followed-up by means of electrocardiography or Holter monitoring. Risk factors associated with AF recurrence were determined by a Cox regression model and the predictive power was evaluated by receiver operating characteristic (ROC) curve.
  
  
  RESULTS
  After (34 ± 18) months follow-up, 30% (12/40) cases remained in sinus rhythm off antiarrhythmic drug, most AF recurrence (18/28, 64.3%) occurred within 1 year post ablation. Multivariate Cox regression demonstrated that left atrial dimension (LAD, HR = 1.124, 95% CI 1.051-1.202, P = 0.001) and female gender (HR = 3.304, 95% CI 1.397-7.817, P = 0.007) were independent risk factors of AF recurrence. The cut-off value of LAD at 43.5 mm predicted AF recurrence with sensitivity of 93.5% and specificity of 60.0%. Every 1 mm enlargement in LAD was associated with an increased risk of arrhythmia recurrence (HR = 1.095, 95% CI 1.031-1.163, P = 0.003).
  
  
  CONCLUSIONS
  AF ablation in Chinese HCM patients is safe and feasible. However, sinus rhythm maintenance rate is low at long-time follow-up. Most of the recurrent AF occurs within 1 year post AF ablation procedure. Left atrial diameter and female gender are independent risk factors of AF recurrence.
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Songnan
authors.initials: S
authors.lastname: Wen
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Nian
authors.initials: N
authors.lastname: Liu
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Songnan
authors.initials: S
authors.lastname: Li
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Man
authors.initials: M
authors.lastname: Ning
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Junping
authors.initials: J
authors.lastname: Kang
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Wu
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Ruan
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Chenxi
authors.initials: C
authors.lastname: Jiang
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Caihua
authors.initials: C
authors.lastname: Sang
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Ribo
authors.initials: R
authors.lastname: Tang
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Deyong
authors.initials: D
authors.lastname: Long
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Ronghui
authors.initials: R
authors.lastname: Yu
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Bai
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Jianzeng
authors.initials: J
authors.lastname: Dong
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Liu
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China; Email: chshma@vip.sina.com.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Ma
mesh_terms: D000889:Anti-Arrhythmia Agents; D001281:Atrial Fibrillation / Q000473:pathology / Q000628:therapy*; D000068476:Beijing; D002312:Cardiomyopathy, Hypertrophic; D017115:Catheter Ablation; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006325:Heart Atria / Q000033:anatomy & histology*; D006801:Humans; D008297:Male; D011667:Pulmonary Veins; D012372:ROC Curve; D012008:Recurrence; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents