title: Do CHA2 DS2 VASc and HAS-BLED scores influence 'real-world' anticoagulation management in atrial fibrillation? 1556 patient registry from the reference cardiology centre.
abstract: BACKGROUND
  Although recommendations for the antithrombotic management of atrial fibrillation (AF) are based on strong evidence, the European guidelines are not fully implemented into practice.
  
  
  OBJECTIVE
  The objective of this study is to analyse antithrombotic treatment in AF in Poland after the publication of the European Society of Cardiology Guidelines in 2012.
  
  
  METHODS
  We retrospectively studied 1556 patients with AF from the Reference Cardiology University Centre in Poland in 2012-2014.
  
  
  RESULTS
  CHA2 DS2 VASc and HAS-BLED scores were 3.5 ± 1.7 and 2.4 ± 1.1. Anti-vitamin K agent were prescribed in 59%, with non-vitamin K antagonist oral anticoagulants in 12%, acetylsalicylic acid (ASA) alone in 18%. Older patients (p < 0.0001) and with paroxysmal AF were less likely to receive oral anticoagulation (OAC, p < 0.0001). The risk of stroke according to CHA2 DS2 VASc score was higher in patients who did not receive OAC (p < 0.0001). The use of OAC increased with increasing CHA2 DS2 VASc score but was less frequent in score ≥ 4. The risk of bleeding was higher in patients without OAC (p < 0.0001). The odds of non-vitamin K antagonist oral anticoagulants use were lower for older patients, patients with ischaemic heart disease, chronic heart failure, anaemia, HAS-BLED ≥ 3 and valvular AF. ASA was given in 39% of the patients, especially in paroxysmal AF (p < 0.0001). The odds of ASA alone were higher for older patients, with ischaemic heart disease and history of myocardial infarction (p < 0.0001). The odds of use of ASA as the only treatment were 5.5 times higher for HAS-BLED ≥ 3 (p < 0.0001).
  
  
  CONCLUSIONS
  Antithrombotic management in AF is well implemented in Polish conditions, but we show the lack of pattern concerning who is being treated with OAC and ASA when it comes to the risk of stroke and bleeding.
authors.affiliation: Department of Cardiology, Medical University in Bialystok, Bialystok, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Lopatowska
authors.affiliation: Department of Cardiology, Medical University in Bialystok, Bialystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Tomaszuk-Kazberuk
authors.affiliation: Department of Cardiology, Medical University in Bialystok, Bialystok, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Mlodawska
authors.affiliation: Department of Invasive Cardiology, Medical University in Bialystok, Bialystok, Poland.|Department of Clinical Medicine, Medical University in Bialystok, Bialystok, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Bachorzewska-Gajewska
authors.affiliation: Second Department of Nephrology and Hypertension with Dialysis Unit, Medical University in Bialystok, Bialystok, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Malyszko
authors.affiliation: Department of Invasive Cardiology, Medical University in Bialystok, Bialystok, Poland.
authors.forename: Slawomir
authors.initials: S
authors.lastname: Dobrzycki
authors.affiliation: Department of Cardiology, Medical University in Bialystok, Bialystok, Poland.
authors.forename: Wlodzimierz J
authors.initials: WJ
authors.lastname: Musial
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000097:blood / Q000188:drug therapy*; D015415:Biomarkers; D002309:Cardiology; D003657:Decision Making; D005260:Female; D006299:Health Services for the Aged; D006801:Humans; D002546:Ischemic Attack, Transient / Q000139:chemically induced / Q000453:epidemiology*; D008297:Male; D011044:Poland / Q000453:epidemiology; D017410:Practice Guidelines as Topic; D012042:Registries; D012189:Retrospective Studies
chemical_list: D000925:Anticoagulants; D015415:Biomarkers
keywords: CHA2DS2VASc score; HAS-BLED score; anticoagulation treatment; atrial fibrillation; pharmacoepidemiology