title: TRP genes family expression in colorectal cancer.
abstract: Colorectal cancer (CRC) is the most common cancer of the gastrointestinal tract. Different factors are responsible for the development of CRC. Transient Receptor Potential (TRP) which is an important component of calcium channel is associated with several pathological conditions like cancer, neurodegenerative and cardiovascular diseases. Thirty members of the family of TRP ion channel in mammals have been determined till now. The aim of this study is to investigate TRPM, TRPV and TRPC gene expression levels in tumor tissues of CRC patients and to analyze the relationship of expression in tumor tissue of CRC with other known prognostic factors.
  
  
  METHODS
  In this study, 93 CRC patients were included. The level of TRP gene expression in paraffin blocks of normal and cancerous colorectal tissue samples were studied at the level of mRNA with Real-time PCR.
  
  
  RESULTS
  The mRNA expression level of TRPV3, TRPV4, TRPV5, TRPM4 and TRPC6 genes in 37 female and 56 male patients diagnosed with CRC was revealed lower in tumor tissue as compared to normal tissue (p < 0.05). No statistically significant differences of mRNA expression levels of other TRP genes were found.
  
  
  CONCLUSIONS
  TRP gene family like TRPV3, TRPV4, TRPV5, TRPM4 and TRPC6 may be thought as potential genes contributing to tumorigenesis as their expression decreases in CRC as compared to normal tissues.
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Gaziantep University, Gaziantep TR-27310, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Sozucan
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Gaziantep University, Gaziantep TR-27310, Turkey.
authors.forename: M E
authors.initials: ME
authors.lastname: Kalender
authors.affiliation: Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep TR-27310, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Sari
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Gaziantep University, Gaziantep TR-27310, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Suner
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Gaziantep University, Gaziantep TR-27310, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Oztuzcu
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Gaziantep University, Gaziantep TR-27310, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Arman
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Adiyaman University, Adiyaman TR-02040, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Yumrutas
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Adiyaman University, Adiyaman TR-02040, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Bozgeyik
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Gazi University, Ankara TR-06560, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Cengiz
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Gaziantep University, Gaziantep TR-27310, Turkey.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Igci
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Sutcu Imam University, Kahramanmaras, TR-46100, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Balakan
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Gaziantep University, Gaziantep TR-27310, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Camci
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D005810:Multigene Family; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D050051:Transient Receptor Potential Channels / Q000235:genetics*
chemical_list: D050051:Transient Receptor Potential Channels