title: Proteostasis trumps YAP in colon cancer.
abstract: In this issue of Science Signaling, Zhang et al. find a new role for verteporfin in the control of colorectal cancer progression through the selective induction of proteotoxicity rather than through inhibition of the transcription cofactor YAP. The study further documents the potential strategy of targeting proteostasis to kill cancer cells.
authors.affiliation: Oncogenesis Stress Signaling Laboratory, ER440 INSERM, Université de Rennes 1, Rennes, France. Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France.
authors.forename: Tony
authors.initials: T
authors.lastname: Avril
authors.affiliation: Oncogenesis Stress Signaling Laboratory, ER440 INSERM, Université de Rennes 1, Rennes, France. Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France. eric.chevet@inserm.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Chevet
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000037:antagonists & inhibitors*; D000230:Adenocarcinoma / Q000188:drug therapy*; D000236:Adenoma / Q000188:drug therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D006801:Humans; D009363:Neoplasm Proteins / Q000187:drug effects*; D010750:Phosphoproteins / Q000037:antagonists & inhibitors*; D011166:Porphyrins / Q000494:pharmacology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D010750:Phosphoproteins; D011166:Porphyrins