title: Gene × Environment Determinants of Stress- and Anxiety-Related Disorders.
abstract: The burgeoning field of gene-by-environment (G×E) interactions has revealed fascinating biological insights, particularly in the realm of stress-, anxiety-, and depression-related disorders. In this review we present an integrated view of the study of G×E interactions in stress and anxiety disorders, including the evolution of genetic association studies from genetic epidemiology to contemporary large-scale genome-wide association studies and G×E studies. We convey the importance of consortia efforts and collaboration to gain the large sample sizes needed to move the field forward. Finally, we discuss several robust and well-reproduced G×E interactions and demonstrate how epidemiological identification of G×E interactions has naturally led to a plethora of basic research elucidating the mechanisms of high-impact genetic variants.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322.|McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, email: kressler@mclean.harvard.edu.
authors.forename: Sumeet
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322.
authors.forename: Abigail
authors.initials: A
authors.lastname: Powers
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322.|Atlanta VA Medical Center, US Department of Veterans Affairs, Decatur, Georgia 30033.
authors.forename: Bekh
authors.initials: B
authors.lastname: Bradley
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322.|McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, email: kressler@mclean.harvard.edu.
authors.forename: Kerry J
authors.initials: KJ
authors.lastname: Ressler
mesh_terms: D001008:Anxiety Disorders / Q000235:genetics* / Q000523:psychology*; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D012307:Risk Factors; D012931:Social Environment
keywords: anxiety; depression; epigenetics; gene-by-environment interaction; genome-wide association study; posttraumatic stress disorder; stress; trauma