title: First magenetic resonance imaging studies on aluminium maltolate-treated aged New Zealand rabbits: an Alzheimer's animal model.
abstract: BACKGROUND
  Alzheimer's disease is a devastative neurodegenerative disorder. To date, there has been no animal model that could unravel the complete disease pathology. Magnetic resonance imaging has played a pivotal role in the quantitative assessment of brain tissue atrophy for a few decades. In particular, temporal lobe atrophy and ventricular dilatation have been found to be sensitive in Alzheimer's disease.
  
  
  METHODS
  The present study focused on the replication of these crucial pathological events to enable disease progression to be diagnosed at an early stage and stopped through the use of potential therapeutic strategies.
  
  
  RESULTS
  The objective of this study was to show temporal lobe atrophy and ventricular dilatation in aluminium maltolate-treated aged New Zealand rabbit, and our study was able to demonstrate this for the first time.
  
  
  CONCLUSIONS
  The present study makes this animal model a substantial one for further molecular level studies and opens up new targets for potential therapeutic strategies.
authors.affiliation: Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki-305-8573, Japan.
authors.forename: Obulesu
authors.initials: O
authors.lastname: Magisetty
authors.affiliation: Department of Biotechnology, Sri Krishnadevaraya University, Anantapur, India.
authors.forename: Muralidhara Rao
authors.initials: MR
authors.lastname: Dowlathabad
authors.affiliation: Department of Radiology, Vikram Hospital, Mysore, Karnataka, India.
authors.forename: Keshav P
authors.initials: KP
authors.lastname: Raichurkar
authors.affiliation: Department of Anatomy, JSS Medical College, Mysore, Karnataka, India.
authors.forename: Shamasundar N
authors.initials: SN
authors.lastname: Mannar
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001284:Atrophy / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009498:Neurotoxins / Q000633:toxicity*; D009942:Organometallic Compounds / Q000633:toxicity*; D011753:Pyrones / Q000633:toxicity*; D011817:Rabbits; D013702:Temporal Lobe / Q000473:pathology*
chemical_list: D009498:Neurotoxins; D009942:Organometallic Compounds; D011753:Pyrones; C067527:aluminum maltolate
keywords: Alzheimer's disease; MRI; aluminium maltolate; temporal lobe atrophy; ventricular dilatation