title: Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management.
abstract: Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis. In this review, we present a case of cyclophosphamide-induced cardiomyopathy requiring mechanical circulatory support. We also describe the pathophysiology, clinical manifestations, and risk factors for this important clinical entity and propose early detection and management strategies.
authors.affiliation: University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Sumandeep
authors.initials: S
authors.lastname: Dhesi
authors.affiliation: University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Chu
authors.affiliation: University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Gregg
authors.initials: G
authors.lastname: Blevins
authors.affiliation: University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Ian
authors.initials: I
authors.lastname: Paterson
authors.affiliation: University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Loree
authors.initials: L
authors.lastname: Larratt
authors.affiliation: University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Gavin Y
authors.initials: GY
authors.lastname: Oudit
authors.affiliation: University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Kim
keywords: cardiomyopathy; cardiotoxicity; cyclophosphamide; heart failure; mechanical circulatory support; myocarditis