title: Epigenetic control of podocyte differentiation: a new target of the renin-angiotensin system in kidney disease.
abstract: Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Denis
authors.initials: D
authors.lastname: Feliers
mesh_terms: D000419:Albuminuria / Q000517:prevention & control*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D008297:Male; D050199:Podocytes / Q000187:drug effects*; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy*; D012084:Renin-Angiotensin System / Q000187:drug effects*; D013777:Tetrazoles / Q000494:pharmacology*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D051741:Kruppel-Like Transcription Factors; D013777:Tetrazoles