title: Ultrafine Betulin Formulation with Biocompatible Carriers Exhibiting Improved Dissolution Rate.
abstract: The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Myza
authors.forename: Tatyana P
authors.initials: TP
authors.lastname: Shakhtshneidera
authors.forename: Mikhail A
authors.initials: MA
authors.lastname: Mikhailenkob
authors.forename: Andrey G
authors.initials: AG
authors.lastname: Ogienkoc
authors.forename: Ekaterina G
authors.initials: EG
authors.lastname: Bogdanovaa
authors.forename: Anna A
authors.initials: AA
authors.lastname: Ogienkoe
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Kuznetsovaf
authors.forename: Elena V
authors.initials: EV
authors.lastname: Boldyrevaa
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Boldyreva
mesh_terms: D029662:Betula / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility; D014315:Triterpenes / Q000737:chemistry*; D000094062:Betulinic Acid
chemical_list: D004337:Drug Carriers; D005998:Glycine; D010936:Plant Extracts; D011092:Polyethylene Glycols; D014315:Triterpenes; C002503:betulin; D000094062:Betulinic Acid