title: Rhodium-catalyzed Asymmetric Hydrogenation of α-Dehydroamino Ketones: A General Approach to Chiral α-amino Ketones.
abstract: Rhodium/DuanPhos-catalyzed asymmetric hydrogenation of aliphatic α-dehydroamino ketones has been achieved and afforded chiral α-amino ketones in high yields and excellent enantioselectives (up to 99 % ee), which could be reduced further to chiral β-amino alcohols by LiAlH(tBuO)3 with good yields. This protocol provides a readily accessible route for the synthesis of chiral α-amino ketones and chiral β-amino alcohols.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, China.
authors.forename: Wenchao
authors.initials: W
authors.lastname: Gao
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, China.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, China. huilv@whu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Lv
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, China. xumu@whu.edu.cn.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D006865:Hydrogenation; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*
chemical_list: D007659:Ketones; D012238:Rhodium
keywords: P ligands; asymmetric catalysis; hydrogenation; rhodium; α-amino ketones