title: Molecular prognostic prediction in liver cirrhosis.
abstract: The natural history of cirrhosis varies and therefore prognostic prediction is critical given the sizable patient population. A variety of clinical prognostic indicators have been developed and enable patient risk stratification although their performance is somewhat limited especially within relatively earlier stage of disease. Molecular prognostic indicators are expected to refine the prediction, and potentially link a subset of patients with molecular targeted interventions that counteract poor prognosis. Here we overview clinical and molecular prognostic indicators in the literature, and discuss critical issues to successfully define, evaluate, and deploy prognostic indicators as clinical scores or tests. The use of liver biopsy has been diminishing due to sampling variability on fibrosis assessment and emergence of imaging- or lab test-based fibrosis assessment methods. However, recent rapid developments of genomics technologies and selective molecular targeted agents has highlighted the need for biopsy tissue specimen to explore and establish molecular information-guided personalized/stratified clinical care, and eventually achieve "precision medicine".
authors.affiliation: Nicolas Goossens, Shigeki Nakagawa, Yujin Hoshida, Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Goossens
authors.affiliation: Nicolas Goossens, Shigeki Nakagawa, Yujin Hoshida, Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nakagawa
authors.affiliation: Nicolas Goossens, Shigeki Nakagawa, Yujin Hoshida, Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Hoshida
mesh_terms: D000818:Animals; D005819:Genetic Markers; D023281:Genomics; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D025202:Molecular Diagnostic Techniques; D018579:Patient Selection; D057285:Precision Medicine; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D005819:Genetic Markers
keywords: Biomarker; Cirrhosis; Gene expression; Hepatocellular carcinoma; Prognosis