title: Effects of Whole Body Vibration Exercise associated with Quadriceps Resistance Exercise on functioning and quality of life in patients with knee osteoarthritis: a randomized controlled trial.
abstract: OBJECTIVE
  To determine effects of Whole Body Vibration Exercise (WBVE) associated with quadriceps resistance exercises (QRE) versus QRE only on pain, physical function, biomarkers in serum and urine, activities of daily living (ADL), and quality of life in patients with knee osteoarthitis (OA).
  
  
  METHODS
  Randomized-controlled trial .
  
  
  METHODS
  Rehabilitation medicine outpatient department of West China Hospital, Chengdu, Sichuan, People's Republic of China.
  
  
  METHODS
  Forty-nine patients were assigned to WBVE+QRE and 50 to QRE .
  
  
  METHODS
  Primary outcomes included pain assessed with visual analogue scale (VAS), Timed up & go test (TUG), 6-min walk distance test (6MWD), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Secondary outcomes comprised range of motion, muscular strength, serum COMP and urinary CTX-II, Lequesne Index (LI), and SF-36. All outcomes were analyzed with mixed effects regression.
  
  
  RESULTS
  Compared with QRE, WBVE+QRE showed signiﬁcantly greater improvement in VAS at 4weeks ( p=0.03), in VAS ( p<0.01), 6MWD ( p=0.01), WOMAC pain ( p=0.01), and WOMAC physical function ( p=0.02) at 16 weeks, and in all primary outcomes at 24 weeks (all p<0.01).
  
  
  CONCLUSIONS
  Over a six months period, WBVE in combination with QRE was superior to QRE in most outcomes.
authors.affiliation: 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.|2 Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, People's Republic of China.
authors.forename: Pu
authors.initials: P
authors.lastname: Wang
authors.affiliation: 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.|2 Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.|2 Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, People's Republic of China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
authors.affiliation: 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.|2 Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, People's Republic of China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Wei
authors.affiliation: 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.|2 Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, People's Republic of China.
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Yang
authors.affiliation: 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.|2 Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, People's Republic of China.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.affiliation: 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Zhongjie
authors.initials: Z
authors.lastname: Lei
authors.affiliation: 3 Institute for Disaster Management and Reconstruction of Sichuan University and Hong Kong Polytechnic University, Chengdu, Sichuan, People's Republic of China.|5 Department of Health Sciences and Health Policy, University of Lucerne, Lucerne, Switzerland.
authors.forename: Jan D
authors.initials: JD
authors.lastname: Reinhardt
authors.affiliation: 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.|2 Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, People's Republic of China.
authors.forename: Chengqi
authors.initials: C
authors.lastname: He
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D016001:Confidence Intervals; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000534:rehabilitation*; D010147:Pain Measurement; D011379:Prognosis; D052097:Quadriceps Muscle / Q000502:physiology; D011788:Quality of Life; D016059:Range of Motion, Articular / Q000502:physiology; D055070:Resistance Training / Q000379:methods*; D018570:Risk Assessment; D012720:Severity of Illness Index; D016037:Single-Blind Method; D013624:Taiwan; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D014732:Vibration / Q000627:therapeutic use*
keywords: COMP; CTX-II; Osteoarthritis; pain; physical function; resistance exercise; whole body vibration