title: Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus.
abstract: Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.
authors.affiliation: School of Medicine, University of California Riverside, Riverside, California 92521, USA.
authors.forename: Ilhem
authors.initials: I
authors.lastname: Messaoudi
authors.affiliation: The Division of Biology &Biomedical Sciences, Washington University in St. Louis, St. Louis, Missouri 63110, USA.
authors.forename: Gaya K
authors.initials: GK
authors.lastname: Amarasinghe
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Basler
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D019142:Hemorrhagic Fever, Ebola / Q000209:etiology* / Q000276:immunology; D057131:Immune Evasion; D007113:Immunity, Innate; D007372:Interferons / Q000096:biosynthesis; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D000072019:Kelch-Like ECH-Associated Protein 1; D008379:Marburg Virus Disease / Q000209:etiology* / Q000276:immunology; D050794:STAT1 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D014764:Viral Proteins / Q000502:physiology; D054334:Viral Regulatory and Accessory Proteins / Q000737:chemistry / Q000502:physiology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1; D050794:STAT1 Transcription Factor; C446938:VP24 protein, Ebola virus; C080980:VP35 protein, filovirus; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; D007372:Interferons