title: Application of an Asthma Screening Questionnaire in Children with Sickle Cell Disease.
abstract: Objective:Asthma in sickle cell disease (SCD) patients is associated with elevated morbidity and mortality. Early detection and initiation of treatment may therefore lead to improved outcome. Utility of an asthma screening questionnaire to identify obstructive airway disease and physician diagnosed asthma in children with SCD at an outpatient setting as an effective, easy-to-administer screening tool has not previously been evaluated in this population.Methods:A previously validated asthma screening questionnaire and spirometry were prospectively administered to 41 SCD children at a routine clinic visit.Results:Prevalence of obstructive airway was 51.2% (n= 21) and physician diagnosis of asthma 33.3% (n= 13). Sensitivity (40%) and specificity (75%) of the questionnaire was poor in detecting obstructive airway disease, but sensitivity (77%), specificity (100%), positive predictive value (100%), and negative predictive value (90%) were high in detecting physician diagnosis of asthma.Conclusion:An asthma screening questionnaire could be a useful tool in identifying at-risk SCD children who may benefit from further management.
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas.
authors.forename: Aravind
authors.initials: A
authors.lastname: Yadav
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas. ; Division of Pediatrics Hematology-Oncology, Department of Pediatrics, University of Miami-Miller School of Medicine , Miami, FL.
authors.forename: Fernando F
authors.initials: FF
authors.lastname: Corrales-Medina
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas.
authors.forename: James M
authors.initials: JM
authors.lastname: Stark
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas.
authors.forename: S Shahrukh
authors.initials: SS
authors.lastname: Hashmi
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas.
authors.forename: Mary P
authors.initials: MP
authors.lastname: Carroll
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas.
authors.forename: Keely G
authors.initials: KG
authors.lastname: Smith
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas.
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Meulmester
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas.
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Brown
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas.
authors.forename: Cindy
authors.initials: C
authors.lastname: Jon
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center , Houston Medical School, Houston, Texas.
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Mosquera