title: Can living donor liver transplantation offer similar outcomes to deceased donor liver transplantation using expanded selection criteria for hepatocellular carcinoma?
abstract: OBJECTIVE
  To compare the outcomes of living donor liver transplantation (LDLT) versus deceased donor liver transplantation (DDLT) for patients with hepatocellular carcinoma (HCC) in different selection criteria.
  
  
  METHODS
  Data of patients with HCC who underwent liver transplantation between 2005 and 2013 at our center were reviewed. Clinical data of LDLT recipients and DDLT recipients were compared. The postoperative recurrence-free survival (RFS) rate and overall survival (OS) rate after LDLT versus DDLT were compared in the Milan recipients, the University of California, San Francisco (UCSF) recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients.
  
  
  RESULTS
  Data of 255 patients were retrospectively reviewed in this study. Seventeen DDLT recipient and 9 LDLT recipients died during the perioperative period. Among the remaining 229 recipients (NLDLT=66, NDDLT=163), 96 patients met the Milan criteria, 123 recipients met the UCSF criteria, 135 patients met the up-to-seven criteria, 216 patients met the Hangzhou criteria, and 229 recipients met the Chengdu criteria. The overall RFS and OS rates of the Milan recipients, the UCSF recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients after LDLT and DDLT were all similar.
  
  
  CONCLUSIONS
  Using well-studied selection criteria, LDLT offers similar outcomes to DDLT for patient with HCC, even using expanded selection criteria.
authors.affiliation: Li-Ping Chen, Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu-610041, China. Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Chen
authors.affiliation: Chuan Li, Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.affiliation: Tian-Fu Wen, Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.
authors.forename: Tian-Fu
authors.initials: TF
authors.lastname: Wen
authors.affiliation: Lu-Nan Yan, Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.
authors.forename: Lu-Nan
authors.initials: LN
authors.lastname: Yan
authors.affiliation: Bo Li, Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Jia-Yin Yang, Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Yang
keywords: Alpha-fetoprotein (AFP); Deceased donor liver transplantation; Deceased donor liver transplantation (DDLT); Hepatocellular carcinoma; Hepatocellular carcinoma (HCC); Living donor liver transplantation; Living donor liver transplantation (LDLT); Microvascular invasion (MVI); Milan criteria; Model for end-stage liver disease (MELD); Outcomes; Recurrence-free survival (RFS) rate and overall survival (OS); University of California, San Francisco (UCSF)