title: Salinazinones A and B: Pyrrolidinyl-Oxazinones from Solar Saltern-Derived Streptomyces sp. KMF-004.
abstract: Salinazinones A (1) and B (2), two unprecedented pyrrolidinyl-oxazinones, were isolated from the culture broth of Streptomyces sp. KMF-004 from a solar saltern at Aphae Island, Korea. The structures of these salinazinones, which are unusual and consist of 2-methylpropenyl-1,3-oxazin-6-one bearing 1-oxopyrrolidinyl substituents, were assigned by spectral and chemical analyses using Mosher's method, circular dichroism (CD), and calculated ECD. Salinazinones are the first examples of a natural alkaloid class composed of an oxazinone-pyrrolidone conjugate.
authors.affiliation: Natural Products Research Center, Korea Institute of Science and Technology (KIST) , Gangneung, Gangwon-do 210-340, Republic of Korea.
authors.forename: Min Cheol
authors.initials: MC
authors.lastname: Kim
authors.affiliation: Natural Products Research Center, Korea Institute of Science and Technology (KIST) , Gangneung, Gangwon-do 210-340, Republic of Korea.|Department of Marine Molecular Biotechnology, Gangneung-Wonju National University , Gangwon-do 210-702, Republic of Korea.
authors.forename: Jung Hwan
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Republic of Korea.
authors.forename: Bora
authors.initials: B
authors.lastname: Shin
authors.affiliation: College of Pharmacy, Gachon University , Yeonsu-gu, Incheon 40-799, Republic of Korea.|Gachon Institute of Pharmaceutical Science, Gachon University , Yeonsu-gu, Incheon 406-799, Republic of Korea.
authors.forename: Lalita
authors.initials: L
authors.lastname: Subedi
authors.affiliation: Natural Products Research Center, Korea Institute of Science and Technology (KIST) , Gangneung, Gangwon-do 210-340, Republic of Korea.
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Cha
authors.affiliation: Natural Products Research Center, Korea Institute of Science and Technology (KIST) , Gangneung, Gangwon-do 210-340, Republic of Korea.
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Park
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Republic of Korea.
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
authors.affiliation: College of Pharmacy, Gachon University , Yeonsu-gu, Incheon 40-799, Republic of Korea.|Gachon Institute of Pharmaceutical Science, Gachon University , Yeonsu-gu, Incheon 406-799, Republic of Korea.
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Natural Products Research Center, Korea Institute of Science and Technology (KIST) , Gangneung, Gangwon-do 210-340, Republic of Korea.
authors.forename: Hak Cheol
authors.initials: HC
authors.lastname: Kwon
mesh_terms: D000818:Animals; D002942:Circular Dichroism; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D056910:Republic of Korea; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D008070:Lipopolysaccharides; D010078:Oxazines; D011759:Pyrrolidines; C000604289:salinazinone A; C000604290:salinazinone B; D009569:Nitric Oxide