title: Nanosponge Carriers- An Archetype Swing in Cancer Therapy: A Comprehensive Review.
abstract: Nanotechnology and nanomedicines are emerging research meadows; which chiefly focuses on creating and manipulating materials at a nanometer level for the betterment in imaging, diagnosis and treatment of a range of diseases together with cancer. Cyclodextrin-based nanosponges, anticipated as a new-fangled nanosized delivery system, are ground-breaking hyper-crosslinked cyclodextrin polymers nanostructured within a three-dimensional network. Nanosponges based systems hold the potential of elevating the solubility, absorption, penetration, bioavailability, in vivo stability, targeted as well as sustained delivery, and therapeutic efficiency of numerous anticancer agents. The extension of nanosponges based drug delivery systems is an exhilarating and demanding research pasture, predominantly to overcome aforementioned problems allied to existing anticancer formulations and for the further progressions in cancer therapies. Nanosponges in cancer therapy, particularly cyclodextrin based nanosponges are brought up in this review. By quoting diverse attempts made in pertinent direction, efforts have been made to exemplify the characteristics, suitability and versatility of cyclodextrin based nanosponges for their promising applications in cancer treatment.
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysuru-570 015, Karnataka, India.
authors.forename: Riyaz Ali M
authors.initials: RA
authors.lastname: Osmani
authors.forename: Umme
authors.initials: U
authors.lastname: Hani
authors.forename: Rohit R
authors.initials: RR
authors.lastname: Bhosale
authors.forename: Parthasarathi K
authors.initials: PK
authors.lastname: Kulkarni
authors.forename: Seetharaman
authors.initials: S
authors.lastname: Shanmuganathan
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002986:Clinical Trials as Topic; D003505:Cyclodextrins / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D049329:Nanostructures; D009369:Neoplasms / Q000188:drug therapy*; D010316:Particle Size
chemical_list: D000970:Antineoplastic Agents; D003505:Cyclodextrins; C041953:cyclodextrin polymer; D002482:Cellulose