title: Topical use of Matricaria recutita L (Chamomile) Oil in the Treatment of Monosymptomatic Enuresis in Children: A Double-Blind Randomized Controlled Trial.
abstract: OBJECTIVE
  To evaluate the efficacy of topical use of Matricaria recutita L oil in the treatment of enuresis in children.
  
  
  METHODS
  Eighty patients diagnosed as monosymptomatic nocturnal or daytime enuresis were allocated to receive Matricaria recutita L (chamomile) oil or placebo topically for 6 weeks in a double-blind randomized placebo-controlled trial with a parallel design. Patients were evaluated prior to and following 8 weeks of the intervention in terms of frequency of enuresis and any observed adverse events.
  
  
  RESULTS
  The mean frequency of enuresis at the first, second, and third 2 weeks was lower in the intervention group compared with the placebo group, and the differences were statistically significant (P < .001, P = .03, and P < .001, respectively). There was no report of any adverse event in the study groups.
  
  
  CONCLUSIONS
  The findings of this study showed that the topical use of (chamomile) oil can decrease the frequency of nocturia in children with monosymptomatic nocturnal or daytime enuresis.
authors.affiliation: Persian Medicine & Pharmacy Research Center, School of traditional Medicine, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Sharifi
authors.affiliation: Persian Medicine & Pharmacy Research Center, School of traditional Medicine, Tehran University of Medical Science, Tehran, Iran bagherminaei@yahoo.com.
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Minaie
authors.affiliation: Department of Medicine, Qom Branch, Islamic Azad University, Qom, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Qasemzadeh
authors.affiliation: Department of Pediatric Nephrology, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Nematollah
authors.initials: N
authors.lastname: Ataei
authors.affiliation: Department of Medicine, Qom Branch, Islamic Azad University, Qom, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Gharehbeglou
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Heydari
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D031168:Matricaria / Q000737:chemistry*; D053206:Nocturnal Enuresis / Q000188:drug therapy*; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts
keywords: Matricaria recutita; enuresis; herbal medicine; traditional medicine; urinary incontinence