title: Serum and Vitreous Concentrations of Omentin-1 in Diabetic Retinopathy.
abstract: OBJECTIVE
  Omentin, a new discovered adipokine, is implicated to inhibit inflammation. Inflammation is one important mechanism of diabetic retinopathy (DR). The purpose of this work was to evaluate serum and vitreous concentrations of omentin-1 in patients with diabetic retinopathy (DR).
  
  
  METHODS
  This study enrolled 204 diabetic patients (60 without DR, 49 with NPDR, and 95 with PDR) and 65 control subjects.
  
  
  RESULTS
  Serum and vitreous omentin-1 levels in PDR patients were markedly decreased compared with those in the other three groups. NPDR patients showed reduced vitreous omentin-1 compared with patients without DR. In addition, control subjects had significantly higher levels of serum and vitreous omentin-1 compared with diabetic patients without DR, NPDR patients, and PDR patients. In addition, serum/vitreous omentin-1 ratio was positively correlated with the development and severity of DR.
  
  
  CONCLUSIONS
  Serum and vitreous omentin-1 levels, as well as serum/vitreous omentin-1 ratio, are correlated with the presence and severity of DR.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Wencui
authors.initials: W
authors.lastname: Wan
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Qiuming
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Fengyan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Guangying
authors.initials: G
authors.lastname: Zheng
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Wan
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Jin
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D003930:Diabetic Retinopathy / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins