title: Neonatal BO Incompatibility Is Associated With a Positive Cord Blood Direct Antiglobulin Test in Infants of Black Ethnicity.
abstract: ABO hemolytic disease of the newborn occurs almost exclusively in infants of blood group A and B who are born to group O mothers. Positive Direct Antiglobulin Test (DAT) can identify those infants who are at risk of developing the ABO hemolytic disease. Earlier studies have suggested that BO incompatibility is associated with a positive DAT in black infants. In this study we sought to determine whether ABO incompatibility type could be associated with a higher rate of DAT positivity or clinical hemolytic disease. We reviewed the electronic medical records of all ABO-incompatible births over a 2-year period. There were 1537 ABO-incompatible births during the study period. DAT was more commonly positive among BO incompatible (21.5% in BO vs. 14.8% in AO, P=0.001) and black (18.8% in blacks vs. 10.8% in nonblacks, P=0.003) infants. DAT positivity was significantly associated with both severe hyperbilirubinemia (P=0.028) and hemolytic anemia (P<0.001). BO incompatibility was significantly associated with hemolytic anemia, but not severe hyperbilirubinemia, in the infants tested.
authors.affiliation: *Hematology/Oncology, Children's Hospital of Michigan ‡Hematology/Oncology, Karmanos Cancer Institute §Transfusion Medicine, Harper University Hospital †Wayne State University, Detroit, MI.
authors.forename: Bülent
authors.initials: B
authors.lastname: Özgönenel
authors.forename: Geetika
authors.initials: G
authors.lastname: Kukreja
authors.forename: Barbara
authors.initials: B
authors.lastname: O'Malley
authors.forename: Martin H
authors.initials: MH
authors.lastname: Bluth
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics / Q000276:immunology*; D000328:Adult; D000745:Anemia, Hemolytic, Congenital / Q000097:blood / Q000208:ethnology / Q000235:genetics; D044383:Black People / Q000235:genetics*; D001787:Blood Group Incompatibility / Q000208:ethnology / Q000276:immunology*; D003298:Coombs Test; D004899:Erythroblastosis, Fetal / Q000097:blood* / Q000208:ethnology / Q000235:genetics; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000208:ethnology / Q000235:genetics; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology; D012189:Retrospective Studies
chemical_list: D000017:ABO Blood-Group System; D007518:Isoantibodies