title: Association of IOP with Systemic Factors in a Korean Cohort.
abstract: OBJECTIVE
  To assess the relationship of intraocular pressure (IOP) to age, sex, and other demographic and health characteristics in a Korean cohort.
  
  
  METHODS
  This retrospective cross-sectional study included subjects (n = 155,198) without glaucoma. All participants underwent health screening at the Kangbuk Samsung Hospital from August 2012 to July 2013. Anthropometric measurements, systemic health characteristics, and ocular examination including noncontact tonometry were performed on all participants. Additionally, sociodemographic and behavioral questionnaires were obtained. The systemic variables were analyzed by multiple regression analysis to identify their relationship with IOP.
  
  
  RESULTS
  The mean IOP tended to be highest in subjects in their 50s and lowest in subjects in their 20s and 60s for both Korean men and women. This pattern remained the same after adjusting for several demographic and health characteristics. The mean IOP for men was significantly higher than that for women (p < 0.001), but the difference between sexes decreased with increasing age. In the univariate analysis, almost all systemic factors showed a positive association with IOP except for high-density lipoprotein cholesterol. By multiple regression analysis, IOP was positively associated with sex (male), current smoking status, systolic blood pressure, fasting plasma glucose, body mass index, total cholesterol, and high-density lipoprotein (p ≤ 0.001).
  
  
  CONCLUSIONS
  In a Korean cohort, the mean IOP was highest in subjects in their 50s. The mean IOP for men was significantly higher than that for women. Several systemic factors were significantly correlated with IOP.
authors.affiliation: *MD †MPH Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (YJK, JMK, SHS, JHB); Department of Ophthalmology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea (YSC); Division of Biostatistics, Department of Medical Information, Kangbuk Samsung Hospital, Seoul, Republic of Korea (MYL); Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea (CKY); and Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea (KHP).
authors.forename: Yang Jae
authors.initials: YJ
authors.lastname: Kim
authors.forename: Yeoun Sook
authors.initials: YS
authors.lastname: Chun
authors.forename: Mi Yeon
authors.initials: MY
authors.lastname: Lee
authors.forename: Joon Mo
authors.initials: JM
authors.lastname: Kim
authors.forename: Seong Hee
authors.initials: SH
authors.lastname: Shim
authors.forename: Chungkwon
authors.initials: C
authors.lastname: Yoo
authors.forename: Jeong Hun
authors.initials: JH
authors.lastname: Bae
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000886:Anthropometry; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D012189:Retrospective Studies; D012737:Sex Factors; D011795:Surveys and Questionnaires; D014065:Tonometry, Ocular; D055815:Young Adult