title: LASSBio-1425, an analog of thalidomide, decreases triglyceride and increases HDL cholesterol levels by inhibition of TNF-α production.
authors.affiliation: Laboratory of Experimental Pharmacology (LAFE), Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University (UFF), Room 204-A, 24210-130 Niterói, RJ, Brazil.
authors.forename: Milla Machado
authors.initials: MM
authors.lastname: Fumian
authors.affiliation: Laboratory of Experimental Pharmacology (LAFE), Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University (UFF), Room 204-A, 24210-130 Niterói, RJ, Brazil.
authors.forename: Nadia Alice Vieira
authors.initials: NA
authors.lastname: da Motta
authors.affiliation: Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio®), Federal University of Rio de Janeiro (UFRJ), Center for Health Sciences (CCS), P.O. Box 68024, 21944-971 Rio de Janeiro, RJ, Brazil.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Maia
authors.affiliation: Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio®), Federal University of Rio de Janeiro (UFRJ), Center for Health Sciences (CCS), P.O. Box 68024, 21944-971 Rio de Janeiro, RJ, Brazil.
authors.forename: Carlos Alberto Manssour
authors.initials: CA
authors.lastname: Fraga
authors.affiliation: Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio®), Federal University of Rio de Janeiro (UFRJ), Center for Health Sciences (CCS), P.O. Box 68024, 21944-971 Rio de Janeiro, RJ, Brazil.
authors.forename: Eliezer Jesus
authors.initials: EJ
authors.lastname: Barreiro
authors.affiliation: Laboratory of Experimental Pharmacology (LAFE), Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University (UFF), Room 204-A, 24210-130 Niterói, RJ, Brazil. Electronic address: fernandabrito@vm.uff.br.
authors.forename: Fernanda Carla
authors.initials: FC
authors.lastname: Ferreira de Brito
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000037:antagonists & inhibitors / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D014280:Triglycerides / Q000037:antagonists & inhibitors / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D013792:Thalidomide
keywords: Anti-inflammatory agents; Antiplatelet drugs; Atherosclerosis; Hypercholesterolemic diet; Lipid-lowering drugs; Phthalimide derivative