title: Umbilical blood gas analysis in preeclamptic versus healthy pregnancies with preterm birth.
abstract: OBJECTIVE
  Comparing the value of umbilical cord arterial blood gas (UC-ABG) analysis in the prediction of neonatal mortality and morbidity in the preeclamptic versus healthy pregnancies with preterm birth.
  
  
  METHODS
  Eight hundred sixteen preterm (born at <37 gestational weeks) neonates with no other morbidities who were born by cesarean section were evaluated. Immediately after delivery, UC-ABG analysis was performed and the neonates were followed.
  
  
  RESULTS
  Preeclamptic women had lower umbilical cord blood (UCB) pH (7.2 4 ± 0.1 versus 7.2 7 ± 0.08, p = 0.008) and higher UCB base deficit (BD) (3.5 ± 3.7 versus 2.2 ± 3.4, p = 0.005) compared with controls. In the preeclamptic group, UCB metabolic acidosis (pH < 7.15 and B.D > 8) was not independently associated with neonatal morbidity or mortality, while in the control group UCB metabolic acidosis was independently associated with low 10-min Apgar (OR, 4.9; 95%CI 1.37-18.03), respiratory distress syndrome (OR, 2.37; 95%CI 1.05-6.17), intraventricular hemorrhage (OR, 3.01; 95%CI 1.13-7.99), and neonatal mortality (OR, 17.33; 95%CI 4.51-66.53).
  
  
  CONCLUSIONS
  The preterm neonates born to preeclamptic mothers have lower UCB pH and higher BD. In these neonates, UCB acidosis is not independently associated with any adverse neonatal outcomes. In contrast, in the preterm neonates born to healthy mothers, UCB metabolic acidosis is independently associated with neonatal mortality and morbidity.
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences , Tehran , Iran .|b Breastfeeding Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences , Tehran , Iran , and.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Sheikh
authors.affiliation: c Pediatrics Intensive Care Unit, Bahrami Children Hospital, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mojdeh Habibi
authors.initials: MH
authors.lastname: Zoham
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences , Tehran , Iran .
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Hantoushzadeh
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences , Tehran , Iran .|b Breastfeeding Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences , Tehran , Iran , and.
authors.forename: Mamak
authors.initials: M
authors.lastname: Shariat
authors.affiliation: b Breastfeeding Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences , Tehran , Iran , and.
authors.forename: Hosein
authors.initials: H
authors.lastname: Dalili
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences , Tehran , Iran .
authors.forename: Elaheh
authors.initials: E
authors.lastname: Amini
mesh_terms: D000138:Acidosis / Q000378:metabolism*; D001784:Blood Gas Analysis / Q000379:methods*; D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D008297:Male; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies
keywords: Acidosis; IVH; RDS; cord; morbidity; mortality