title: Polymorphism of MDM2 promoter 309 (rs 2279744) and the risk of PCOS.
abstract: This study aimed at evaluating possible association between MDM2 SNP309 polymorphism (rs 2279744) and polycystic ovary syndrome (PCOS). One hundred and twenty-five women with PCOS and two hundred and fifty women without PCOS were collected from the department of reproductive medicine of college hospital in this case-control study. Peripheral blood samples were collected from all participants and DNA was extracted, MDM2 SNP309 polymorphism (rs 2279744) was determined from the 125 cases and 250 controls. Women were grouped into PCOS (n = 125) group and control group (n = 250). Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the association between MDM2 SNP309 polymorphism (rs 2279744) and PCOS. The distribution of T allele was significant higher in PCOS cases than controls. MDM2 SNP 309 T allele is associated with PCOS.
authors.affiliation: a Lab of Molecular Genetics of Aging & Tumor, Faculty of Medicine , Kunming University of Science and Technology , Kunming , Yunnan , China , and.|b Department of Reproductive Medicine , The Second Affiliated Hospital of Kunming Medical University , Kunming , Yunnan , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chan
authors.affiliation: a Lab of Molecular Genetics of Aging & Tumor, Faculty of Medicine , Kunming University of Science and Technology , Kunming , Yunnan , China , and.
authors.forename: Hongguo
authors.initials: H
authors.lastname: Jiang
authors.affiliation: b Department of Reproductive Medicine , The Second Affiliated Hospital of Kunming Medical University , Kunming , Yunnan , China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Yang
authors.affiliation: b Department of Reproductive Medicine , The Second Affiliated Hospital of Kunming Medical University , Kunming , Yunnan , China.
authors.forename: Dongya
authors.initials: D
authors.lastname: Li
authors.affiliation: b Department of Reproductive Medicine , The Second Affiliated Hospital of Kunming Medical University , Kunming , Yunnan , China.
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.affiliation: a Lab of Molecular Genetics of Aging & Tumor, Faculty of Medicine , Kunming University of Science and Technology , Kunming , Yunnan , China , and.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.affiliation: a Lab of Molecular Genetics of Aging & Tumor, Faculty of Medicine , Kunming University of Science and Technology , Kunming , Yunnan , China , and.
authors.forename: Wenru
authors.initials: W
authors.lastname: Tang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012306:Risk
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
keywords: MDM2; PCOS; polymorphism