title: [Early epithelial lesions in prophylactic annexectomies in patients at high risk of ovarian cancer: Report of a series of 93 cases].
abstract: OBJECTIVE
  Tubal lesions detected in specimen of risk reducing salpingo oophorectomy (RRSO) for mutation BRCA1/2 seems to play a role in ovarian carcinogenesis. The main objective of this study is to evaluate the prevalence of occult neoplasia, of Serous Tubal Intraepithelial Carcinoma (STIC), and signature P53 in a cohort of patients who underwent a risk reducing salpingo oophorectomy.
  
  
  METHODS
  From January 2010 to January 2014 unicentric, retrospective study on a consecutive cases cohort of RRSO for patients with a high risk of ovarian neoplasia (mutation BRCA 1/2 or family history). Pathological specimen should be analysed according to the SEE-FIM protocol.
  
  
  RESULTS
  Ninety-three RRSO were recorded. Among them, 44% of the patients had the germ line mutation BRCA1, 30.1% BRAC2 and 18.2% had no identified mutation. In all, 33.3% of the RRSO reveal a signature P53, in the fimbria for 93.9%, 7.9% of them were bilateral. 1,1‰ (n=1) of the patients presented a unilateral STIC. We obtained 4.3% of occult neplasia: 3 ovarian high-grade serous carcinomas and 1 tubal high-grade serous carcinoma. Only the tubal carcinoma coexists with STIC.
  
  
  CONCLUSIONS
  5,4% of the patients who underwent RRSO had a diagnostic of occult neoplasia. One percent of the patients had an isolated STIC. These results agree with recent data of the literature. Extensive examination of the Fallopian tube opens up a new way to understand ovarian carcinogenesis.
authors.affiliation: Département d'oncologie chirurgicale, institut de cancérologie de l'Ouest-René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain cedex, France. Electronic address: gabrielleselmes@hotmail.fr.
authors.forename: G
authors.initials: G
authors.lastname: Selmes
authors.affiliation: Département de chirurgie de l'IUCT-O, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
authors.forename: G
authors.initials: G
authors.lastname: Ferron
authors.affiliation: Département de biostatistiques de l'IUCT-O, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
authors.forename: T
authors.initials: T
authors.lastname: Filleron
authors.affiliation: Département de chirurgie de l'IUCT-O, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
authors.forename: D
authors.initials: D
authors.lastname: Querleu
authors.affiliation: Département d'anatomopathologie de l'IUCT-O, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
authors.forename: E
authors.initials: E
authors.lastname: Mery
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000517:prevention & control*; D018095:Germ-Line Mutation; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology* / Q000517:prevention & control*; D010052:Ovariectomy; D011446:Prospective Studies; D012189:Retrospective Studies; D058994:Salpingectomy
keywords: Annexectomie prophylactique; BRCA; Carcinome séreux tubaire in situ; Risk reducing salpingo oophorectomy; Serous tubal intraepithelial carcinoma; Signature P53