title: A new player in chronic kidney disease mineral and bone disorder: tenascin-C.
abstract: OBJECTIVE
  Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a condition frequently observed in CKD. The search for a reliable and easy to use biomarker in the diagnosis of CKD-MBD is continuing. Tenascin-C (TN-C) is an important extracellular (ECM) protein synthesized by osteoblasts during bone growth and morphogenesis. The purpose of this study was to assess the relation between inflammation and MBD and TN-C in HD patients and to identify a new marker that can be used to help diagnose CKD-MBD.
  
  
  METHODS
  136 HD patients and 22 healthy controls were enrolled in this cross-sectional, observational multicenter study. Once patients' demographic and biochemical parameters had been recorded, peripheral blood samples were collected for TN-C measurement before the mid-week HD session. The relationship between TN-C levels and demographic and biochemical parameters was then assessed.
  
  
  RESULTS
  TN-C levels were significantly higher in the HD patient than in the control group (P&lt;.001). Intact parathormone (iPTH) affected TN-C levels in the HD patient group. TN-C levels was significantly higher in both the high (&gt;300 pg/ml) and low iPTH groups (&lt;150 pg/ml) compared to the 150-300 pg/ml iPTH group (P&lt;.001, &lt;.001 respectively).
  
  
  CONCLUSIONS
  This study showed, for the first time in the literature, high levels of TN-C in the low and high iPTH groups and that this elevation was associated with iPTH. We think that if our study is supported by further research, TN-C can be a biomarker capable of use in diagnosing CKD-MBD.
authors.affiliation: Department of Nephrology, Hatay Antakya State Hospital, Hatay - Turkey.
authors.forename: Gulsum
authors.initials: G
authors.lastname: Ozkan
authors.affiliation: Department of Nephrology, Karadeniz Technical University, School of Medicine, Trabzon - Turkey.
authors.forename: Sukru
authors.initials: S
authors.lastname: Ulusoy
authors.affiliation: Department of Internal Medicine, Karadeniz Technical University, School of Medicine, Trabzon - Turkey.
authors.forename: Beyhan
authors.initials: B
authors.lastname: Guvercin
authors.affiliation: Department of Clinical Biochemistry, Karadeniz Technical University, School of Medicine, Trabzon - Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Menteşe
authors.affiliation: Department of Clinical Biochemistry, Karadeniz Technical University, School of Medicine, Trabzon - Turkey.
authors.forename: Suleyman Caner
authors.initials: SC
authors.lastname: Karahan
authors.affiliation: Trabzon RNS Hemodialysis Center, Trabzon - Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Yavuz
mesh_terms: D015415:Biomarkers / Q000097:blood; D001851:Bone Diseases, Metabolic / Q000097:blood*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010281:Parathyroid Hormone / Q000097:blood; D051436:Renal Insufficiency, Chronic / Q000097:blood*; D019063:Tenascin / Q000097:blood*
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D019063:Tenascin