title: Epirubicin-gold nanoparticles suppress hepatocellular carcinoma xenograft growth in nude mice.
abstract: We sought to investigate the effects of epirubicin-nanogold compounds (EPI-AuNP) on hepatocellular carcinoma xenograft growth in nude mice. EPI-AuNP was prepared and hepatoma xenograft model was established in nude mice. The mice were then randomly divided into four groups: the control group with injection of saline, the AuNP treatment group, the EPI treatment group and the EPI-AuNP treatment group. After two weeks, the hepatoma weight and volume of the xenografts were assessed. Our transmission electron microscopy revealed that epirubicin-gold nanoparticles caused significantly more structural changes of hepatocellular carcinoma cells HepG2. The tumor weight in the Epi-AuNP treatment group (0.80±0.11g) was significantly lower than that of the control group (2.48±0.15 g), the AuNP treatment group (1.67±0.17 g), and the EPI treatment group (1.39±0.10g) (P<0.01). Furthermore, the tumor volume of mice in the EPI-AuNP treatment group (0.27±0.06 cm³) was significantly smaller than that of the control group (2.23±0.34 cm³), the AuNP treatment group (1.21±0.25 cm³) and the EPI treatment group (0.81±0.11 cm³) (P<0.01). In conclusion, epirubicin-nanogold compounds (EPI-AuNP) have significant inhibitory effects on the growth of hepatocellular carcinoma cells in vivo.
authors.affiliation: Department of Surgery, Matilda Internatinal Hospital, Hong Kong, China. wmeng@netvigator.com.
authors.forename: William C S
authors.initials: WC
authors.lastname: Meng
authors.affiliation: Department of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Zhao
keywords: HUVEC; HepG2 cells; epirubicin; hepatoma xenograft; nanogold