title: Epidemiological, clinical, virological features of hepatitis B newly diagnosed in 2011 in Marseille University hospitals, southeastern France.
abstract: Hepatitis B virus (HBV) infection is a public health problem. In France, 0.68% of adults are chronically infected. We aimed to describe the epidemiological, virological and clinical characteristics of HBV infections newly diagnosed in 2011 in University hospitals of Marseille, the second largest French city. HBV serology was performed for 18,130 sera from 15,744 patients. A total of 167 patients were newly-diagnosed with HBV based upon the detection of hepatitis B surface antigen and anti-hepatitis B core antibodies. Clinico-epidemiological features were analyzed for 78 patients. Patients included a majority of men (59%), women being significantly younger with a mean age of 36 ± 17 versus 43.5 ± 16.2 years (P = 0.009). Country of birth was available for 52 patients and 35% of them originated from sub-Saharan Africa. Levels of the liver biological parameters were significantly lower in women compared to men, in whom mean alanine aminotransferase and gammaglutamyl transferase levels were 24 ± 39 versus 37 ± 36 IU/l (P = 0.0001) and 20 ± 20 versus 51 ± 53 IU/l (P = 0.0001), respectively. Co-infections with hepatitis C and human immunodeficiency viruses were found in 5% and 6% of the patients, respectively. HBV DNA was detectable in 90% of the HBeAg-negative patients. In addition, there was a positive correlation between the HBsAg titer and the HBV DNA level (P = 0.001). Genotype D was the most common HBV genotype and was found in 53% of the patients tested, followed by genotype E (21%). HBV remains a major concern with a slightly greater number of new diagnoses than in 2004. HBV genetic diversity was substantial in the present cohort.
authors.affiliation: IHU Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Service de Maladies Infectieuses, Centre Hospitalo-Universitaire Nord, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Sahada
authors.initials: S
authors.lastname: Moussa
authors.affiliation: IHU Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Service de Maladies Infectieuses, Centre Hospitalo-Universitaire Nord, Assistance Publique-Hôpitaux de Marseille, Marseille, France.|Aix-Marseille University, URMITE UM63 CNRS 7278 IRD 198 INSERM U1905, Marseille, France.
authors.forename: Souleymane
authors.initials: S
authors.lastname: Brah
authors.affiliation: IHU Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Service de Maladies Infectieuses, Centre Hospitalo-Universitaire Nord, Assistance Publique-Hôpitaux de Marseille, Marseille, France.|Aix-Marseille University, URMITE UM63 CNRS 7278 IRD 198 INSERM U1905, Marseille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Parola
authors.affiliation: Service d'Hépato-Gastro-Entérologie, Centre Hospitalo-Universitaire Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: René
authors.initials: R
authors.lastname: Gerolami
authors.affiliation: Service d'Hépato-Gastro-Entérologie, Centre Hospitalo-Universitaire Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Gamerre
authors.affiliation: Service de Gynecologie-Obstrétique, Centre Hospitalo-Universitaire Nord, Assistance Publique-Hôpitaux de Marseille, chemin des Bourrely, Marseille, France.
authors.forename: Léon
authors.initials: L
authors.lastname: Boubli
authors.affiliation: Assistance-Publique Hôpitaux de Marseille, Hôpitaux Sud, Service de Médecine en milieu pénitentiaire, Centre pénitentiaire de Marseille, Marseille, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Ruiz
authors.affiliation: IHU Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Service de Maladies Infectieuses, Centre Hospitalo-Universitaire Nord, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Ravaux
authors.affiliation: Aix-Marseille University, URMITE UM63 CNRS 7278 IRD 198 INSERM U1905, Marseille, France.
authors.forename: Saada
authors.initials: S
authors.lastname: Mokhtari
authors.affiliation: Assistance Publique-Hôpitaux de Marseille, hôpital Timone, Service Biostatistique et Technologies de l'Information et de la Communication, Marseille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Mancini
authors.affiliation: IHU Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Romera
authors.affiliation: IHU Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Motte
authors.affiliation: Aix-Marseille University, URMITE UM63 CNRS 7278 IRD 198 INSERM U1905, Marseille, France.|IHU Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Tamalet
authors.affiliation: Aix-Marseille University, URMITE UM63 CNRS 7278 IRD 198 INSERM U1905, Marseille, France.|IHU Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Colson
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000453:epidemiology; D005006:Ethnicity; D005260:Female; D005602:France / Q000453:epidemiology; D005838:Genotype; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000150:complications / Q000453:epidemiology* / Q000473:pathology* / Q000821:virology; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase
keywords: France; Marseille; hepatitis B surface antigen; hepatitis B virus; new diagnosis