title: Activation-Induced Cytidine Deaminase and Switched Memory B Cells as Predictors of Effective In Vivo Responses to the Influenza Vaccine.
abstract: Aging impairs humoral immune responses, leading to increased frequency and severity of infectious diseases and reduced protective effects of vaccination. We have identified B-cell biomarkers that are reduced by aging and that can be used as predictive markers of the response of an individual to vaccination. The identification of these biomarkers will have an impact on the development of effective vaccines to protect the elderly from infections and other debilitating diseases.
authors.affiliation: Department of Microbiology and Immunology, University of Miami Miller School of Medicine, RMSB #3146A, 1600 NW 10th Ave, Miami, FL, 33136, USA. dfrasca@med.miami.edu.
authors.forename: Daniela
authors.initials: D
authors.lastname: Frasca
authors.affiliation: Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
authors.forename: Alain
authors.initials: A
authors.lastname: Diaz
authors.affiliation: Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
authors.forename: Bonnie B
authors.initials: BB
authors.lastname: Blomberg
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism*; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D006801:Humans; D017578:Immunoglobulin Class Switching / Q000235:genetics* / Q000276:immunology*; D007156:Immunologic Memory; D018189:Immunomagnetic Separation / Q000379:methods; D007252:Influenza Vaccines / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*
chemical_list: D007252:Influenza Vaccines; D003564:Cytidine Deaminase
keywords: Activation-induced cytidine deaminase; Antibody vaccine response; Class switch recombination