title: Peste des petits ruminants.
abstract: Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants.
authors.affiliation: The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, United Kingdom; National Institute for Animal Biotechnology, Miyapur, Hyderabad, India. Electronic address: satya.parida@pirbright.ac.uk.
authors.forename: S
authors.initials: S
authors.lastname: Parida
authors.affiliation: The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Muniraju
authors.affiliation: The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Mahapatra
authors.affiliation: Indian Veterinary Research Institute, Mukteswar, India.
authors.forename: D
authors.initials: D
authors.lastname: Muthuchelvan
authors.affiliation: Animal and Plant Health Agency, Weybridge, Surrey, KT15 3NB United Kingdom.
authors.forename: H
authors.initials: H
authors.lastname: Buczkowski
authors.affiliation: Animal and Plant Health Agency, Weybridge, Surrey, KT15 3NB United Kingdom.
authors.forename: A C
authors.initials: AC
authors.lastname: Banyard
mesh_terms: D000349:Africa / Q000453:epidemiology; D000818:Animals; D001208:Asia / Q000453:epidemiology; D058507:Host Specificity; D008877:Middle East / Q000453:epidemiology; D029021:Peste-des-Petits-Ruminants / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D018107:Peste-des-petits-ruminants virus / Q000145:classification / Q000235:genetics* / Q000502:physiology; D012418:Ruminants / Q000276:immunology / Q000821:virology*; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D014765:Viral Vaccines
keywords: Control and eradication; Country-wise virus circulation; Live attenuated vaccine; Molecular evolution; PPR; Pathogenesis; Potential DIVA and multivalent vaccine; Reverse genetics