title: Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis.
abstract: OBJECTIVE
  To investigate the association between cyclo-oxygenase-2 (COX-2) polymorphism and the risk of hepatocellular carcinoma (HCC) development.
  
  
  METHODS
  Systematic review and meta-analysis of COX-2 polymorphism and risk of HCC development among people with or without HCC.
  
  
  METHODS
  EMBASE, PubMed, Public Library of Science, SCOPUS, Web of Knowledge and Chinese National Knowledge Infrastructure were searched for all clinical and experimental case-control studies of COX-2 polymorphism and HCC risk. Studies published up to March 2015 were included.
  
  
  METHODS
  Ten studies were included for data extraction, which were mainly from Asian countries.
  
  
  RESULTS
  2538 people with HCC and 3714 without HCC were found to satisfy the inclusion criteria and included in the review. The associations of specific genotypes in the eight polymorphic variants of COX-2 and the risk of HCC development were analysed. GG genotype at the A-1195G polymorphism may be associated with a reduced risk of HCC development: the OR across all studies was 0.87 (95% CI 0.75 to 1.02) for the G allele versus the A allele, 0.72 (0.53 to 0.97) for GG versus AA, 0.72 (0.57 to 0.92) for GG versus GA+AA and 1.05 (0.77 to 1.44) for AA versus GA+GG. Similar results were found when the meta-analysis was repeated separately for the Chinese subgroup. However, more reliable data are needed to demonstrate associations between variants in G-765C, T+8473C, A-1290G, G-899C and introns 1, 5 and 6 polymorphisms and the risk of HCC development.
  
  
  CONCLUSIONS
  Only the COX-2 A-1195G gene polymorphism may be associated with a decreased risk of HCC development. These conclusions should be verified in further studies.
authors.affiliation: Hepatobiliary Surgery Department, First Affiliated Hospital of Guangxi Medical University, Nanning, PR China.
authors.forename: Si-Cong
authors.initials: SC
authors.lastname: Lu
authors.affiliation: Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Zhong
authors.affiliation: Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
authors.forename: Jun-Tao
authors.initials: JT
authors.lastname: Tan
authors.affiliation: Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
authors.forename: Hua-Lin
authors.initials: HL
authors.lastname: Tang
authors.affiliation: Hepatobiliary Surgery Department, First Affiliated Hospital of Guangxi Medical University, Nanning, PR China.
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Liu
authors.affiliation: Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
authors.forename: Bang-De
authors.initials: BD
authors.lastname: Xiang
authors.affiliation: Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
authors.forename: Le-Qun
authors.initials: LQ
authors.lastname: Li
authors.affiliation: Hepatobiliary Surgery Department, First Affiliated Hospital of Guangxi Medical University, Nanning, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D004273:DNA, Neoplasm; D051546:Cyclooxygenase 2
keywords: cyclooxygenase-2; hepatocellular carcinoma; polymorphism; susceptibility