title: Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum.
abstract: Two enantiomeric pairs of meroterpenoids, (-)- and (+)-rhodonoids A (1a and 1b) and B (2a and 2b), were isolated unprecedentedly from partially racemic mixtures that naturally occurred in Rhododendron capitatum. Their structures were fully determined by spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. Compounds 1a and 1b are the first examples of meromonoterpenes featuring a unique 6/6/6/4 ring system. Compounds 2a and 2b showed PTP1B inhibitory activity.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University , 826 Zhang Heng Road, Shanghai 201203, China.
authors.forename: Hai-Bing
authors.initials: HB
authors.lastname: Liao
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University , 826 Zhang Heng Road, Shanghai 201203, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Lei
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guo Shou Jing Road, Shanghai 201203, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Gao
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guo Shou Jing Road, Shanghai 201203, China.
authors.forename: Jing-Ya
authors.initials: JY
authors.lastname: Li
authors.affiliation: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guo Shou Jing Road, Shanghai 201203, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University , 826 Zhang Heng Road, Shanghai 201203, China.
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D029793:Rhododendron / Q000737:chemistry*; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D013729:Terpenes; C000604291:rhodonoid A; C000604292:rhodonoid B; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1