title: Association between oral feeding intolerance and quality of life in acute pancreatitis: A prospective cohort study.
abstract: OBJECTIVE
  Oral feeding intolerance (OFI) is a common complication of nutritional management in acute pancreatitis (AP) and is associated with significantly worse clinical outcomes and increased cost of treatment. However, changes in patient-reported outcomes associated with OFI during AP and effect of OFI on quality of life (QoL) have, to our knowledge, never been studied. The aim of this study was to investigate the relationship between OFI and QoL in patients with AP.
  
  
  METHODS
  We conducted a prospective cohort study of patients with AP. Patients were grouped according to whether they developed OFI during hospitalization. QoL was recorded daily during hospitalization and at 1 and 4 wk after discharge. One-way analysis of covariance and repeated measures analysis were conducted. P < 0.05 was accepted as statistically significant.
  
  
  RESULTS
  The study included 131 patients with AP. Fifty-two (40%) developed OFI during hospitalization. Overall QoL was significantly impaired in the OFI group (mean difference = -16.1; 95% confidence interval, -24.4 to -7.8; P ≤ 0.001). Five individual domains-physical limitations, psychological function, sleep, pain, and visceral function-were significantly impaired in the OFI group during hospitalization. Overall QoL improved significantly within each group from hospitalization to follow-up (P < 0.001) with no significant difference between the two groups at follow-up (mean difference = -2; 95% confidence interval, -7.1 to 3.2; P = 0.449).
  
  
  CONCLUSIONS
  QoL is significantly impaired in patients with AP who develop OFI. Nutritional management of acute pancreatitis needs to be optimized to prevent the occurrence of OFI.
authors.affiliation: Department of Surgery, University of Auckland, Auckland, New Zealand.
authors.forename: Sayali A
authors.initials: SA
authors.lastname: Pendharkar
authors.affiliation: Department of Surgery, University of Auckland, Auckland, New Zealand.
authors.forename: Varsha
authors.initials: V
authors.lastname: Asrani
authors.affiliation: Department of Surgery, University of Auckland, Auckland, New Zealand.
authors.forename: Stephanie L M
authors.initials: SL
authors.lastname: Das
authors.affiliation: Department of Surgery, University of Auckland, Auckland, New Zealand.
authors.forename: Landy M
authors.initials: LM
authors.lastname: Wu
authors.affiliation: Department of Surgery, University of Auckland, Auckland, New Zealand.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Grayson
authors.affiliation: Department of Surgery, University of Auckland, Auckland, New Zealand.
authors.forename: Lindsay D
authors.initials: LD
authors.lastname: Plank
authors.affiliation: Department of Surgery, University of Auckland, Auckland, New Zealand.
authors.forename: John A
authors.initials: JA
authors.lastname: Windsor
authors.affiliation: Department of Surgery, University of Auckland, Auckland, New Zealand. Electronic address: Max.petrov@gmail.com.
authors.forename: Maxim S
authors.initials: MS
authors.lastname: Petrov
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D004435:Eating; D001068:Feeding and Eating Disorders / Q000209:etiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology*; D018529:Nutritional Support; D010146:Pain / Q000209:etiology*; D010195:Pancreatitis / Q000150:complications* / Q000628:therapy; D011788:Quality of Life; D012890:Sleep; D014839:Vomiting / Q000209:etiology*
keywords: Acute pancreatitis; Oral feeding intolerance; Patient-reported outcomes; Quality of life