title: Triple-negative breast carcinoma: heterogeneity in immunophenotypes and pharmacokinetic behavior.
abstract: OBJECTIVE
  To evaluate the morphokinetic, pharmacokinetic, and diffusion characteristics of triple-negative breast cancers on magnetic resonance (MR) imaging and to analyze whether there is a relation between these parameters and the time to progression.
  
  
  METHODS
  This was a retrospective observational study of a consecutive series of 100 patients with histologically confirmed triple-negative breast cancer studied at our center between January 2005 and December 2010. We reviewed the findings on MR locoregional extension studies, the histological findings, and the follow-up of patients until August 2014.
  
  
  RESULTS
  The most common MR findings for these tumors were a rounded mass (47.3%), well-defined borders (53.7%), ring enhancement (46.2%), type 3 curves (50.5%), hyperintensity within the tumor on T2-weighted sequences, high ADC values (1.04 × 10(-3) mm2/s), and increased capillary permeability (Kep) (0.94 min(-1)). No significant association was observed between the morphokinetic or pharmacokinetic characteristics and the time to progression. The in situ component in the surgical specimens was high, although its expression was low. During follow-up, 25% of patients had metastases, with a predilection for the visceral organs, and survival was low.
  
  
  CONCLUSIONS
  Tumors with the triple-negative phenotype mostly presented in MR as rounded tumors with well-defined borders and ring enhancement. We found no significant association between the morphokinetic or pharmacokinetic characteristics and the time to progression.
authors.affiliation: Área de Radiología Ginecológica y Mamaria, UDIAT Centre Diagnòstic, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí-UAB, Sabadell, España. Electronic address: m.vilagran@tauli.cat.
authors.forename: M
authors.initials: M
authors.lastname: Vilagran Fraguell
authors.affiliation: Área de Radiología Ginecológica y Mamaria, UDIAT Centre Diagnòstic, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí-UAB, Sabadell, España.
authors.forename: M
authors.initials: M
authors.lastname: Sentís Crivillé
authors.affiliation: Área de Radiología Ginecológica y Mamaria, UDIAT Centre Diagnòstic, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí-UAB, Sabadell, España.
authors.forename: J
authors.initials: J
authors.lastname: del Riego Ferrari
authors.affiliation: Servicio de Anatomía Patológica, UDIAT Centre Diagnòstic, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí-UAB, Sabadell, España.
authors.forename: F J
authors.initials: FJ
authors.lastname: Andreu Navarro
authors.affiliation: Servicio de Oncología, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí-UAB, Sabadell, España.
authors.forename: E
authors.initials: E
authors.lastname: Dalmau Portulàs
authors.affiliation: Área de Radiología Mamaria, Fundació Privada Hospital Asil de Granollers, Hospital Universitari, Hospital General de Granollers, Granollers, España.
authors.forename: J
authors.initials: J
authors.lastname: Planas Roquerols
authors.affiliation: Servicio de Epidemiología y Cribado de Cáncer, UDIAT Centre Diagnòstic, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí-UAB, Sabadell, España.
authors.forename: M
authors.initials: M
authors.lastname: Lluïsa Baré
mesh_terms: D002277:Carcinoma / Q000000981:diagnostic imaging; D006801:Humans; D016130:Immunophenotyping; D008279:Magnetic Resonance Imaging; D010599:Pharmacokinetics; D012189:Retrospective Studies; D064726:Triple Negative Breast Neoplasms / Q000000981:diagnostic imaging*
keywords: Breast cancer; Cáncer de mama; Fenotipo triple negativo; Magnetic resonance imaging; Resonancia magnética; Triple-negative phenotype