title: Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD).
abstract: p62/sequestosome-1 is a multidimensional protein that interacts with many signaling factors, and regulates a variety of cellular functions including inflammation, apoptosis, and autophagy. Our previous work has revealed in the retinal pigment epithelium (RPE) that p62 promotes autophagy and simultaneously enhances an Nrf2-mediated antioxidant response to protect against acute oxidative stress. Several recent studies demonstrated that p62 contributes to NFkB mediated inflammation and inflammasome activation under certain circumstances, raising the question of whether p62 protects against or contributes to tissue injury. Herein, we will review the general characteristics of p62, focusing on its pro- and anti-cell survival roles within different physiological/pathological contexts, and discuss the potential of p62 as a therapeutic target for AMD.
authors.affiliation: Wilmer Eye Institute, Johns Hopkins School of Medicine, 400 N Broadway, Rm 3001-D, the Smith Building, 21287, Baltimore, MD, USA. leiwang.011@gmail.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Wilmer Eye Institute, Johns Hopkins School of Medicine, 400 N Broadway, Rm 3001-D, the Smith Building, 21287, Baltimore, MD, USA. kebrahi2@jhmi.edu.
authors.forename: Katayoon B
authors.initials: KB
authors.lastname: Ebrahimi
authors.affiliation: Wilmer Eye Institute, Johns Hopkins School of Medicine, 400 N Broadway, Rm 3001-D, the Smith Building, 21287, Baltimore, MD, USA. mchyn1@jhu.edu.
authors.forename: Michelle
authors.initials: M
authors.lastname: Chyn
authors.affiliation: Wilmer Eye Institute, Johns Hopkins School of Medicine, 400 N Broadway, Rm 3001-D, the Smith Building, 21287, Baltimore, MD, USA. mcano1@jhmi.edu.
authors.forename: Marisol
authors.initials: M
authors.lastname: Cano
authors.affiliation: Wilmer Eye Institute, Johns Hopkins School of Medicine, 400 N Broadway, Rm 3001-D, the Smith Building, 21287, Baltimore, MD, USA. jthanda@jhmi.edu.
authors.forename: James T
authors.initials: JT
authors.lastname: Handa
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D001343:Autophagy; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D008268:Macular Degeneration / Q000378:metabolism*; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D055213:Retinal Pigment Epithelium / Q000378:metabolism*; D000071456:Sequestosome-1 Protein; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D058847:Inflammasomes; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495635:NFE2L2 protein, human; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein
keywords: AMD; Autophagy; NFKB; Neurodegeneration; Nrf2; PB1; RPE; p62; sqstm1