title: Parametric analysis of the biomechanical response of head subjected to the primary blast loading--a data mining approach.
abstract: Traumatic brain injury due to primary blast loading has become a signature injury in recent military conflicts and terrorist activities. Extensive experimental and computational investigations have been conducted to study the interrelationships between intracranial pressure response and intrinsic or 'input' parameters such as the head geometry and loading conditions. However, these relationships are very complicated and are usually implicit and 'hidden' in a large amount of simulation/test data. In this study, a data mining method is proposed to explore such underlying information from the numerical simulation results. The heads of different species are described as a highly simplified two-part (skull and brain) finite element model with varying geometric parameters. The parameters considered include peak incident pressure, skull thickness, brain radius and snout length. Their interrelationship and coupling effect are discovered by developing a decision tree based on the large simulation data-set. The results show that the proposed data-driven method is superior to the conventional linear regression method and is comparable to the nonlinear regression method. Considering its capability of exploring implicit information and the relatively simple relationships between response and input variables, the data mining method is considered to be a good tool for an in-depth understanding of the mechanisms of blast-induced brain injury. As a general method, this approach can also be applied to other nonlinear complex biomechanical systems.
authors.affiliation: a Department of Mechanical Engineering , Embry-Riddle Aeronautical University , Daytona Beach , Florida , USA.|b Bioengineering Center , Wayne State University , Detroit , Michigan , USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.affiliation: b Bioengineering Center , Wayne State University , Detroit , Michigan , USA.
authors.forename: Anil
authors.initials: A
authors.lastname: Kalra
authors.affiliation: b Bioengineering Center , Wayne State University , Detroit , Michigan , USA.
authors.forename: Tal
authors.initials: T
authors.lastname: Saif
authors.affiliation: c College of Computer and Information Science , Northeastern University , Boston , Massachusetts , USA.
authors.forename: Zaihan
authors.initials: Z
authors.lastname: Yang
authors.affiliation: b Bioengineering Center , Wayne State University , Detroit , Michigan , USA.
authors.forename: King H
authors.initials: KH
authors.lastname: Yang
authors.affiliation: b Bioengineering Center , Wayne State University , Detroit , Michigan , USA.
authors.forename: Albert I
authors.initials: AI
authors.lastname: King
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D001753:Blast Injuries / Q000473:pathology* / Q000503:physiopathology*; D003198:Computer Simulation; D057225:Data Mining; D005107:Explosions; D020342:Finite Element Analysis; D006257:Head / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans
keywords: DOCE; Primary blast induced TBI; data mining; decision tree; finite element analysis