title: Proton magnetic resonance spectroscopy and outcome in term neonates with chorioamnionitis.
abstract: OBJECTIVE
  Evaluate brain metabolites, which reflect neuroinflammation, and relate to neurodevelopmental outcomes in healthy term neonates exposed to chorioamnionitis.
  
  
  METHODS
  Thirty-one healthy term neonates with documented fetal inflammatory response after maternal chorioamnionitis underwent magnetic resonance spectroscopy (MRS), with voxels placed in basal ganglia (BG) and frontal white matter. Bayley III examinations were performed at 12 months of age.
  
  
  RESULTS
  Infants with below average outcomes did not show the same increase in NAA/Cho ratios postnatally as the group with normal outcomes. Decreased NAA/Cho and increased Lac/Cr in BG correlated with lower motor and cognitive composite scores, respectively, controlling for postnatal age. In males, increased lactate/NAA in BG were associated with lower motor scores. Funisitis severity was associated with decreased NAA/Cho and increased mI/NAA in males.
  
  
  CONCLUSIONS
  In healthy term newborns with chorioamnionitis, MRS ratios shortly after birth may provide evidence of occult neuroinflammation, which may be associated with worse performance on 1-year neurodevelopmental tests.
authors.affiliation: Department of Neuroscience's Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC, USA.|Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Johnson
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Jenkins
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Bentzley
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: D
authors.initials: D
authors.lastname: Lambert
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: K
authors.initials: K
authors.lastname: Hope
authors.affiliation: Department of Clinical Psychology, University of Massachusetts, Boston, MA, USA.
authors.forename: L G
authors.initials: LG
authors.lastname: Rollins
authors.affiliation: Department of Medical Physics, Nottingham University Hospitals NHS Trust, Nottingham, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Morgan
authors.affiliation: Department of Neuroscience's Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: T
authors.initials: T
authors.lastname: Brown
authors.affiliation: Department of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: V
authors.initials: V
authors.lastname: Ramakrishnan
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.|Department of Radiology, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Mulvihill
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Katikaneni
mesh_terms: D001479:Basal Ganglia / Q000737:chemistry; D001921:Brain / Q000473:pathology*; D002794:Choline / Q000032:analysis; D002821:Chorioamnionitis / Q000473:pathology*; D003401:Creatine / Q000032:analysis; D004151:Dipeptides / Q000032:analysis; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007249:Inflammation / Q000503:physiopathology; D019344:Lactic Acid / Q000032:analysis; D008297:Male; D015999:Multivariate Analysis; D065886:Neurodevelopmental Disorders / Q000503:physiopathology; D059906:Neuroimaging / Q000379:methods*; D011247:Pregnancy; D066244:Proton Magnetic Resonance Spectroscopy; D012044:Regression Analysis; D047929:Term Birth
chemical_list: D004151:Dipeptides; C027172:isospaglumic acid; D019344:Lactic Acid; D003401:Creatine; D002794:Choline