title: Risk factors for mortality in patients with Staphylococcus aureus bloodstream infection.
abstract: In this two year retrospective analysis, we evaluated the epidemiology and risk factors for mortality of Staphylococcus aureus bloodstream infection (SaBSI). Methicillin-susceptible S. aureus (MSSA) was isolated in 84 (44.2%) and methicillin-resistant S. aureus (MRSA) in 106 episodes (55.8%). The mortality rate after 21 days was 16.4%. At univariate analysis older age, no removal of central venous catheter (CVC), prosthetic heart valves, severe sepsis, septic shock and high APACHE II score were significantly associated with mortality, whereas treatment duration > 48 hours, appropriate targeted therapy and prolonged treatment duration were significantly associated with survival. At multivariate analysis, prosthetic valves, septic shock and fever 48 hours after the diagnosis were significantly related to mortality. In this study, the mortality was associated with clinical rather than microbiological factors.
authors.affiliation: a Department of Medical Sciences , University of Turin, Infectious Diseases at Amedeo di Savoia Hospital , Turin , Italy.
authors.forename: Francesco Giuseppe
authors.initials: FG
authors.lastname: De Rosa
authors.affiliation: a Department of Medical Sciences , University of Turin, Infectious Diseases at Amedeo di Savoia Hospital , Turin , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Corcione
authors.affiliation: a Department of Medical Sciences , University of Turin, Infectious Diseases at Amedeo di Savoia Hospital , Turin , Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Motta
authors.affiliation: a Department of Medical Sciences , University of Turin, Infectious Diseases at Amedeo di Savoia Hospital , Turin , Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Petrolo
authors.affiliation: b Department of Surgical Sciences , University of Turin, Division of Anaesthesia and Critical Care, City of Health and Science, Molinette Hospital , Turin , Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Filippini
authors.affiliation: a Department of Medical Sciences , University of Turin, Infectious Diseases at Amedeo di Savoia Hospital , Turin , Italy.
authors.forename: Nicole
authors.initials: N
authors.lastname: Pagani
authors.affiliation: c Laboratory of Microbiology and Virology , City of Health and Science , Turin , Italy.
authors.forename: Lucina
authors.initials: L
authors.lastname: Fossati
authors.affiliation: d Department of Public Health and Paediatric Science , University of Turin, Laboratory of Microbiology and Virology, City of Health and Science , Turin , Italy.
authors.forename: Rossana
authors.initials: R
authors.lastname: Cavallo
authors.affiliation: a Department of Medical Sciences , University of Turin, Infectious Diseases at Amedeo di Savoia Hospital , Turin , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Perri
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents
keywords: Bloodstream infection; Mortality; Risk factors; Staphylococcus aureus