title: Cortical hyperostosis as a side-effect of prolonged use of prostaglandins.
abstract: Cortical hyperostosis is a very uncommon side-effect of prolonged prostaglandin therapy with distinctive radiological signs that may be accompanied by painful swelling of the limbs and responds rapidly to withdrawal of therapy.
authors.affiliation: 1Department of Pediatric Cardiology,La Paz Hospital,Madrid,Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Rivero Jiménez
authors.affiliation: 2Department of Pediatric Radiology,La Paz Hospital,Madrid,Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Bret-Zurita
authors.affiliation: 1Department of Pediatric Cardiology,La Paz Hospital,Madrid,Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: García-Guereta Silva
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D015576:Hyperostosis / Q000139:chemically induced*; D007223:Infant; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D008297:Male; D013997:Time Factors
chemical_list: D000527:Alprostadil
keywords: CHD; Cortical hyperostosis; ductus arteriosus; prostaglandin E1; side-effects