title: Survivin as a Potential Target for Cancer Therapy.
abstract: In 1997 for the first time, survivin was described by Amborsini et al. as an anti-apoptotic protein. Subsequent studies revealed that survivin is a multifunctional protein that plays critical roles in several crucial cell processes such as apoptosis, cell cycle, chromosome movement, mitosis and cellular stress responses. Moreover, it's over- expression in cancer cells versus normal cells is associated with chemotherapy resistance, increased tumor recurrence, and shorter patient survival. All of these features make survivin a promising target for cancer therapy. Here, we review the potential characteristics of survivin as a tumor marker.
authors.affiliation: Department of Genetics, Faculty of Natural Sciences, University of Tabriz, Tabriz-Iran E-mail : babaei@tabrizu.ac.ir.
authors.forename: Elaheh
authors.initials: E
authors.lastname: Soleimanpour
authors.forename: Esmaeil
authors.initials: E
authors.lastname: Babaei
mesh_terms: D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism; D015316:Genetic Therapy; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000628:therapy; D000077022:Survivin; D014158:Transcription, Genetic / Q000187:drug effects; D015854:Up-Regulation
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin