title: David and Goliath: chemical perturbation of eukaryotes by bacteria.
abstract: Environmental microbes produce biologically active small molecules that have been mined extensively as antibiotics and a smaller number of drugs that act on eukaryotic cells. It is known that there are additional bioactives to be discovered from this source. While the discovery of new antibiotics is challenged by the frequent discovery of known compounds, we contend that the eukaryote-active compounds may be less saturated. Indeed, despite there being far fewer eukaryotic-active natural products these molecules interact with a far richer diversity of molecular and cellular targets.
authors.affiliation: Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
authors.forename: Louis K
authors.initials: LK
authors.lastname: Ho
authors.affiliation: Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. Justin.nodwell@utoronto.ca.
authors.forename: Justin R
authors.initials: JR
authors.lastname: Nodwell
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056890:Eukaryota / Q000737:chemistry / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products
keywords: Actinomycetes; Eukaryotes; Target diversity