title: Refractory Dermatomyositis Complicated with Myelodysplastic Syndrome.
abstract: We herein describe a case of refractory dermatomyositis (DM) complicated with myelodysplastic syndrome (MDS). Despite intensive immunosuppressive therapies, the activity of myositis, skin ulcers, and interstitial pneumonia did not improve. The patient ultimately died following the progression of interstitial pneumonia. There are few reports of DM accompanying MDS to date, and any association in the pathogenesis between the two is still unclear. However, underlying MDS may have the potential to influence the therapeutic response of DM.
authors.affiliation: Division of Hematology and Rheumatology, Department of Internal Medicine, National Defense Medical College, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Horikoshi
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Kusanagi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamamura
authors.forename: Reiko
authors.initials: R
authors.lastname: Takahashi
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Itoh
mesh_terms: D000368:Aged; D003882:Dermatomyositis / Q000150:complications / Q000473:pathology*; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000473:pathology*; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000473:pathology*; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology*