title: [THE IMPACT OF LOWER URINARY TRACT SYMPTOMS ON GENERIC HEALTH-RELATED QUALITY OF LIFE IN MALE PATIENTS WITHOUT CO-MORBIDITY].
abstract: OBJECTIVE
  We investigated the impact of lower urinary tract symptoms (LUTS) on generic health-related quality of life (HRQOL) in male patients without co-morbidity.
  
  
  METHODS
  From 2003 to 2011, a total 567 men who presented out urological department completed the questionnaires including International Prostate Symptom Score (IPSS), incontinence-frequency score (IFS) from the UCLA prostate cancer index, MOS 36-Item Short-Form Health Survey (SF-36). Among 230 patients with no coexisting morbidity, the relations between each LUTS score of IPSS indices and IFS and 8 domain scores of SF-36 were analyzed by Pearson's product-moment correlation and stepwise multiple regression analysis.
  
  
  RESULTS
  Univariate analysis showed that the IFS had a significant correlation with all of 8 domain scores of SF-36, and also the IPSS item scores of urgency, nocturia and straining correlated significantly with multiple domain scores of SF-36. In multiple regression analysis, the proportionate contributions of LUTS to each SF-36 domain scores were low (R2 was 10% or less). Incontinence was considered as the most influential factor that had a negative impact on HRQOL in 7 SF-36 domains of physical functioning, role-physical, bodily pain, general health perception, vitality, social functioning and mental health. Additionally, nocturia, straining and urgency were significantly associated with deficit of HRQOL in 4 SF-36 domains (role-physical, general health perception, role-emotional, mental health), 2 domains (bodily pain, social functioning) and 1 domain (role-emotional) of SF-36, respectively. CONCLUSION; Among LUTS, incontinence, nocturia and straining were the most important symptoms in association with the negative impact on generic HRQOL measured by SF-36.
authors.forename: Takuya
authors.initials: T
authors.lastname: Okada
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kono
authors.forename: Keiyu
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Norihiko
authors.initials: N
authors.lastname: Masuda
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shiraishi
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Negoro
authors.forename: Noriaki
authors.initials: N
authors.lastname: Utsunomiya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsunemori
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Okubo
authors.forename: Takehiko
authors.initials: T
authors.lastname: Segawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Moroi
authors.forename: Koei
authors.initials: K
authors.lastname: Muguruma
authors.forename: Mutsushi
authors.initials: M
authors.lastname: Kawakita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011788:Quality of Life; D011795:Surveys and Questionnaires