title: Salivary metabolomics in the diagnosis of oral cancer and periodontal diseases.
abstract: Metabolomics is a systemic study of metabolites, which are small molecules generated by the process of metabolism. The metabolic profile of saliva can provide an early outlook of the changes associated with a wide range of diseases, including oral cancer and periodontal diseases. It is possible to measure levels of disease-specific metabolites using different methods as presented in this study. However, many challenges exist including incomplete understanding of the complicated metabolic pathways of different oral diseases. The review concludes with the discussion on future perspectives of salivary metabolomics from a clinician point of view. Salivary metabolomics may afford a new research avenue to identify local and systemic disorders but also to aid in the design and modification of therapies. A MEDLINE search using keywords "salivary metabolomics" returned 23 results in total, of which seven were omitted for being reviews or letters to the editor. The rest of the articles were used for preparation of the review, 13 of these were published in the last 5 years.
authors.affiliation: SIB Labs, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.|Institute of Dentistry, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors.forename: J J W
authors.initials: JJ
authors.lastname: Mikkonen
authors.affiliation: SIB Labs, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.|Institute of Dentistry, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors.forename: S P
authors.initials: SP
authors.lastname: Singh
authors.affiliation: Faculty of Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Herrala
authors.affiliation: SIB Labs, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.|Department of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Lappalainen
authors.affiliation: Institute of Dentistry, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.|Department of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Myllymaa
authors.affiliation: Institute of Dentistry, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.|Faculty of Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland.|Educational Dental Clinic, Kuopio University Hospital, Kuopio, Finland.
authors.forename: A M
authors.initials: AM
authors.lastname: Kullaa
mesh_terms: D006801:Humans; D055432:Metabolomics; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D010510:Periodontal Diseases / Q000175:diagnosis* / Q000378:metabolism; D012463:Saliva / Q000378:metabolism*; D013048:Specimen Handling / Q000379:methods
keywords: omic study; oral cancer; periodontal disease; saliva