title: Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival.
abstract: Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained by Ki-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal ; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Campus of Gualtar, 4710-057 Braga, Portugal ; Surgery Department, Hospitalar Center Trás-os-Montes e Alto Douro, Unidade Hospitalar de Chaves, Avenida Dr. Francisco Sá Carneiro, 5400-279 Chaves, Portugal.
authors.forename: Sandra F
authors.initials: SF
authors.lastname: Martins
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal ; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Campus of Gualtar, 4710-057 Braga, Portugal.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Amorim
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
authors.forename: Sílvia Coelho
authors.initials: SC
authors.lastname: Mota
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
authors.forename: Luís
authors.initials: L
authors.lastname: Costa
authors.affiliation: Pathology Department, Braga Hospital, Sete Fontes, São Victor, 4710-243 Braga, Portugal.
authors.forename: Fernando
authors.initials: F
authors.lastname: Pardal
authors.affiliation: Coloproctology Unit, Braga Hospital, Sete Fontes, São Victor, 4710-243 Braga, Portugal.
authors.forename: Mesquita
authors.initials: M
authors.lastname: Rodrigues
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal ; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Campus of Gualtar, 4710-057 Braga, Portugal ; Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of Sao Paulo, 01246-903 São Paulo, SP, Brazil ; Molecular Oncology Research Centre, 14784-400 Barretos, SP, Brazil.
authors.forename: Adhemar
authors.initials: A
authors.lastname: Longatto-Filho
mesh_terms: D015179:Colorectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008207:Lymphatic Metastasis; D008297:Male; D011237:Predictive Value of Tests; D015996:Survival Rate
chemical_list: D019394:Ki-67 Antigen