title: Gender-specific protective effect of the -463G>A polymorphism of myeloperoxidase gene against the risk of essential hypertension in Russians.
abstract: The purpose of this study was to investigate whether a common polymorphism -463G>A (rs2333227) in the promoter of myeloperoxidase (MPO) gene, an oxidant enzyme producing hypohalogenic radicals, is associated with the risk of essential hypertension (EH) in Russian population. A total of 2044 unrelated subjects including 1256 EH patients and 788 normotensive controls were recruited for this study. Genotyping of the MPO gene polymorphism was done using TaqMan-based assay. A genotype -463GA was associated with decreased risk of EH (odds ratio = 0.82; 95% confidence interval: 0.68-1.00) at a borderline significance level (P = .05). The gender-stratified analysis showed that a carriage of the -463GA and -463AA genotypes is associated with decreased EH risk only in females (odds ratio = 0.74, 95% confidence interval: 0.56-0.96; P = .02). To the best of our knowledge, this is the first study reporting a negative association between the -463G>A polymorphism of the MPO gene and EH risk. Molecular mechanisms by which MPO gene is involved in the pathogenesis of EH are discussed.
authors.affiliation: Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation. Electronic address: olga.bushueva@inbox.ru.
authors.forename: Olga
authors.initials: O
authors.lastname: Bushueva
authors.affiliation: Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation.
authors.forename: Maria
authors.initials: M
authors.lastname: Solodilova
authors.affiliation: Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Ivanov
authors.affiliation: Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation.
authors.forename: Alexey
authors.initials: A
authors.lastname: Polonikov
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016001:Confidence Intervals; D000075222:Essential Hypertension; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012426:Russia; D012680:Sensitivity and Specificity; D012737:Sex Factors; D044465:White People / Q000235:genetics
chemical_list: D009195:Peroxidase
keywords: Essential hypertension; gender dimorphism; genetic polymorphism; myeloperoxidase; oxidative stress