title: Long noncoding RNAs could be potential key players in the pathophysiology of Sjögren's syndrome.
abstract: Long noncoding RNAs (lncRNAs) are a recently discovered class of noncoding functional RNAs encoded by metazoan genomes. Recent studies suggest a larger regulatory role for lncRNAs in critical biological and disease processes. Mounting evidence on the role of lncRNAs in regulating key processes of the immune system prompted us to hypothesize the role of lncRNAs as key regulators of the pathophysiology of Sjögren's syndrome (SS). We used two similar approaches based on reanalysis of microarray expression datasets and curation of lncRNA-protein coding gene interactions from literature to derive support for our hypothesis. We also discuss potential caveats to our approach and suggest approaches to validate the hypothesis. Our analysis suggests the potential larger and hitherto unknown role of lncRNA regulatory networks in modulating the expression of key genes involved in the pathogenesis of SS and thereby modulating the pathophysiology of SS.
authors.affiliation: Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India.
authors.forename: Pulukool
authors.initials: P
authors.lastname: Sandhya
authors.affiliation: Open Source Drug Discovery Unit, Delhi, India.|Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, Delhi, India.
authors.forename: Kandarp
authors.initials: K
authors.lastname: Joshi
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, Delhi, India.|GN Ramachandran Knowledge Centre for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.
authors.forename: Vinod
authors.initials: V
authors.lastname: Scaria
mesh_terms: D019295:Computational Biology; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010641:Phenotype; D062085:RNA, Long Noncoding / Q000235:genetics*; D012307:Risk Factors; D012469:Salivary Glands / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology
chemical_list: D005819:Genetic Markers; D062085:RNA, Long Noncoding
keywords: Sjögren's syndrome; autoimmunity; expression; interactome; lncRNA; regulatory network