title: Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient.
abstract: We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient. Hepatotoxicity induced by masitinib, a tyrosine kinase inhibitor, is usually transient with mild elevation of transaminases, although acute hepatitis has been not reported to date. The hepatitis was resolved after masitinib was discontinued and a combination of prednisone and azathioprine was started. The transaminases returned to baseline normal values five months later. This is the first case in the hepatitis literature associated with masitinib. The autoimmune role of this drug-induced liver injury is discussed. Physicians should be aware of this potential complication.
authors.affiliation: Maria Salvado, Josep Gamez, ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Salvado
authors.affiliation: Maria Salvado, Josep Gamez, ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Victor
authors.initials: V
authors.lastname: Vargas
authors.affiliation: Maria Salvado, Josep Gamez, ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Vidal
authors.affiliation: Maria Salvado, Josep Gamez, ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Macarena
authors.initials: M
authors.lastname: Simon-Talero
authors.affiliation: Maria Salvado, Josep Gamez, ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Jessica
authors.initials: J
authors.lastname: Camacho
authors.affiliation: Maria Salvado, Josep Gamez, ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Gamez
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000188:drug therapy*; D001379:Azathioprine / Q000627:therapeutic use; D001549:Benzamides; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D010880:Piperidines; D011241:Prednisone / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D011725:Pyridines; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D013844:Thiazoles / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001549:Benzamides; D007166:Immunosuppressive Agents; D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D013844:Thiazoles; C526575:masitinib; D001379:Azathioprine; D011241:Prednisone
keywords: Amyotrophic lateral sclerosis; Autoimmune-like hepatitis; Autoimmunity; Drug-induced liver injury; Idiosyncratic drug hepatotoxicity; Masitinib; Tirosine kinase inhibitors