title: Burden of serious fungal infections in the Czech Republic.
abstract: We have estimated the number of serious fungal infections in the Czech Republic. All published epidemiology papers reporting Czech fungal infection rates were identified. Where no data existed, we used specific populations at risk and fungal infection frequencies in those populations. Population statistics were obtained from the 2011 Census data, prevalence and incidence data for at-risk conditions were obtained from publicly accessible healthcare statistics and relevant surveys. We estimate that 152,840 Czech women suffer with recurrent vaginal thrush. Allergic bronchopulmonary aspergillosis is likely in 4739 adults and 6581 more have severe asthma with fungal sensitisation. Hypersensitivity pneumonitits secondary to fungi is estimated in 1050 cases and 365 people may have chronic pulmonary aspergillosis. Oesophageal candidiasis is estimated in 210 HIV-positive people. There are 12 cases of Pneumocystis pneumonia in HIV population and 60 more cases in non-HIV population. There are an estimated 526 cases of candidaemia, 79 cases of Candida peritonitis and 297 cases of invasive aspergillosis a year. About 176,000 (1.67%) Czech people suffer from severe fungal infections each year, predominantly from recurrent vaginitis and allergic respiratory conditions. Substantial uncertainty surrounds these estimates except for invasive aspergillosis in haematology and candidaemia in critical care.
authors.affiliation: Department of Infectious Diseases, České Budějovice Hospital, České Budějovice, Czech Republic.
authors.forename: Aleš
authors.initials: A
authors.lastname: Chrdle
authors.affiliation: Laboratory of Parasitology and Mycology, České Budějovice Hospital, České Budějovice, Czech Republic.
authors.forename: Nad'a
authors.initials: N
authors.lastname: Mallátová
authors.affiliation: Department of Respiratory Medicine, First Faculty of Medicine of Charles University, Thomayer University Hospital, Prague, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Vašáková
authors.affiliation: Department of Haematology, First Faculty of Medicine of Charles University, General University Hospital, Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Haber
authors.affiliation: The University of Manchester, Manchester Academic Health Science Centre, National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK.
authors.forename: David W
authors.initials: DW
authors.lastname: Denning
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000453:epidemiology / Q000382:microbiology; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000453:epidemiology / Q000382:microbiology; D001249:Asthma / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D058387:Candidemia / Q000453:epidemiology / Q000382:microbiology; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology; D017281:Cost of Illness; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000191:economics / Q000453:epidemiology* / Q000382:microbiology; D011014:Pneumonia / Q000453:epidemiology / Q000382:microbiology; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology; D015995:Prevalence; D055732:Pulmonary Aspergillosis / Q000453:epidemiology / Q000382:microbiology; D014627:Vaginitis / Q000453:epidemiology / Q000382:microbiology; D055815:Young Adult
keywords: Czech Republic; disease burden; epidemiology; fungal infections