title: Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids.
abstract: OBJECTIVE
  The aim of the study is to evaluate the association of steroid metabolism and respiratory gene polymorphisms in neonates exposed to antenatal corticosteroids (ACS) with respiratory outcomes, small for gestational age (SGA), and response to repeat ACS.
  
  
  METHODS
  This candidate gene study is a secondary analysis of women enrolled in a randomized controlled trial of single versus weekly courses of ACS. Nineteen single nucleotide polymorphisms (SNPs) in 13 steroid metabolism and respiratory function genes were evaluated. DNA was extracted from placenta or fetal cord serum and analyzed with TaqMan genotyping. Each SNP was evaluated for association via logistic regression with respiratory distress syndrome (RDS), continuous positive airway pressure (CPAP)/ventilator use (CPV), and SGA.
  
  
  RESULTS
  CRHBP, CRH, and CRHR1 minor alleles were associated with an increased risk of SGA. HSD11B1 and SCNN1B minor alleles were associated with an increased likelihood of RDS. Carriage of minor alleles in SerpinA6 was associated with an increased risk of CPV. CRH and CRHR1 minor alleles were associated with a decreased likelihood of CPV.
  
  
  CONCLUSIONS
  Steroid metabolism and respiratory gene SNPs are associated with respiratory outcomes and SGA in patients exposed to ACS. Risks for respiratory outcomes are affected by minor allele carriage as well as by treatment with multiple ACS.
authors.affiliation: Departments of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa.
authors.forename: K S
authors.initials: KS
authors.lastname: Borowski
authors.affiliation: University of Utah, Salt Lake City, Utah.
authors.forename: E A S
authors.initials: EA
authors.lastname: Clark
authors.affiliation: The George Washington University Biostatistics Center, Washington, District of Columbia.
authors.forename: Y
authors.initials: Y
authors.lastname: Lai
authors.affiliation: Drexel University, Philadelphia, Pennsylvania.
authors.forename: R J
authors.initials: RJ
authors.lastname: Wapner
authors.affiliation: Wayne State University, Detroit, Michigan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sorokin
authors.affiliation: Departments of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.
authors.forename: A M
authors.initials: AM
authors.lastname: Peaceman
authors.affiliation: Departments of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio.
authors.forename: J D
authors.initials: JD
authors.lastname: Iams
authors.affiliation: Departments of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: K J
authors.initials: KJ
authors.lastname: Leveno
authors.affiliation: Departments of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, North Carolina.
authors.forename: M
authors.initials: M
authors.lastname: Harper
authors.affiliation: Departments of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: S N
authors.initials: SN
authors.lastname: Caritis
authors.affiliation: Columbia University, New York, New York.
authors.forename: M
authors.initials: M
authors.lastname: Miodovnik
authors.affiliation: Departments of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio.
authors.forename: B M
authors.initials: BM
authors.lastname: Mercer
authors.affiliation: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: J M
authors.initials: JM
authors.lastname: Thorp
authors.affiliation: University of Miami, Miami, Florida.
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Sullivan
authors.affiliation: The University of Texas Health Science Center at Houston, Houston, Texas.
authors.forename: S M
authors.initials: SM
authors.lastname: Ramin
authors.affiliation: Departments of Obstetrics and Gynecology, Brown University, Providence, Rhode Island.
authors.forename: M W
authors.initials: MW
authors.lastname: Carpenter
authors.affiliation: University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: D J
authors.initials: DJ
authors.lastname: Rouse
authors.affiliation: Departments of Obstetrics and Gynecology, University of Tennessee, Memphis, Tennessee.
authors.forename: B
authors.initials: B
authors.lastname: Sibai
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000009:adverse effects*; D000328:Adult; D005260:Female; D005838:Genotype; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000139:chemically induced*; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*; D012129:Respiratory Function Tests
chemical_list: D000305:Adrenal Cortex Hormones