title: In vitro cardiac tissue models: Current status and future prospects.
abstract: Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase of potential treatment strategies and better prognostic tools will require a concerted effort from interdisciplinary fields. Biomaterials-based cardiac tissue models are revolutionizing the area of preclinical research and translational applications. The goal of in vitro cardiac tissue modeling is to create physiological functional models of the human myocardium, which is a difficult task due to the complex structure and function of the human heart. This review describes the advances made in area of in vitro cardiac models using biomaterials and bioinspired platforms. The field has progressed extensively in the past decade, and we envision its applications in the areas of drug screening, disease modeling, and precision medicine.
authors.affiliation: Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Bioscience (QB3), Berkeley, CA 94720, USA.
authors.forename: Anurag
authors.initials: A
authors.lastname: Mathur
authors.affiliation: Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Bioscience (QB3), Berkeley, CA 94720, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Bioscience (QB3), Berkeley, CA 94720, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Loskill
authors.affiliation: Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA.
authors.forename: Shaheen
authors.initials: S
authors.lastname: Jeeawoody
authors.affiliation: Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Bioscience (QB3), Berkeley, CA 94720, USA. Electronic address: kehealy@berkeley.edu.
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Healy
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D053595:Embryonic Stem Cells / Q000166:cytology; D006321:Heart / Q000502:physiology*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000166:cytology; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels
keywords: Biomaterials; Cardiac tissue models; Disease modeling; Drug screening; In vitro cardiac tissue engineering; Regenerative medicine; Tissue engineering