title: Chemical composition and cytotoxicity of the essential oil from different parts of Datura metel L.
abstract: The essential oil from different parts of Datura metel L. were extracted using hydrodistillation and GC-MS was used to analyse the essential oil. The main components of flowers were ketone (23.61%) and ethyl palmitate (15.84%). The main components of leaves were ketone (18.84%) and phytol (18.71%). Ketone (39.45%) and phytol (31.32%) were the major components of petioles. Palmitic acid (30.60%) and ethyl linoleate (21.56%) were the major components of seeds. The major ingredient of roots was palmitic acid (52.61%). The main ingredients of the stems were palmitic acid (38.38%) and ethyl linoleate (17.38%). All the different parts of essential oil were screened for cytotoxicity. The roots and stems showed the inhibitory effects against HepG-2 with IC50 levels of 613.88 and 341.12 mg/L. The leaves and roots showed the inhibitory effects against HeLa with IC50 levels of 267.76 and 348.35 mg/L. All the six parts have inhibitory effects against SGC-7901 cell lines.
authors.affiliation: a Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin , China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xue
authors.affiliation: a Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin , China.
authors.forename: Yichun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: a Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.affiliation: a Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin , China.
authors.forename: Changfu
authors.initials: C
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin , China.
authors.forename: Bingyou
authors.initials: B
authors.lastname: Yang
authors.affiliation: a Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin , China.
authors.forename: Haixue
authors.initials: H
authors.lastname: Kuang
authors.affiliation: a Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin , China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D058530:Datura metel / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D009822:Oils, Volatile / Q000032:analysis* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile
keywords: Datura metel L.; GC–MS; cytotoxicity; essential oil