title: Combination treatment with excimer laser and narrowband UVB light in vitiligo patients.
abstract: BACKGROUND
  For the treatment of vitiligo, narrowband UVB (NBUVB) light is considered the most effective for nonsegmental vitiligo, while excimer laser treatment is commonly used for localized vitiligo. However, treatment areas may potentially be missed with excimer laser treatment.
  
  
  OBJECTIVE
  We aimed to evaluate the effect of combinational treatment with NBUVB light and excimer laser on vitiligo.
  
  
  METHODS
  All patients were first treated with NBUVB; excimer laser was then applied in conjunction with NBUVB phototherapy due to a slow response or no further improvement with continuous NBUVB treatment alone. To minimize adverse effects, a fixed dose of NBUVB was administered, and the dose of excimer laser was increased based on patient response.
  
  
  RESULTS
  Among 80 patients, 54 patients showed responses after combination with excimer laser; however, 26 patients (32.5%) showed no remarkable change after combination therapy. Of the 26 patients who showed no further response, 12 patients (46.1%) presented with vitiligo on the acral areas, which are known to the least responsive sites.
  
  
  CONCLUSIONS
  Our study suggests that combined treatment of NBUVB and excimer laser in vitiligo may enhance the treatment response without remarkable side effects, therefore might also increase the compliance of the patients to the treatment.
authors.affiliation: Department of Dermatology, Severance Hospital & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sungsik
authors.initials: S
authors.lastname: Shin
authors.affiliation: Korea Institute of Vitiligo Research & Drs Woo and Hann's Skin Center, Seoul, Korea.
authors.forename: Seung-Kyung
authors.initials: SK
authors.lastname: Hann
authors.affiliation: Department of Dermatology, Severance Hospital & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Oh
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D014466:Ultraviolet Rays; D014820:Vitiligo / Q000628:therapy*
keywords: NBUVB light; combination treatment; excimer laser; vitiligo