title: Ablative fractional laser resurfacing with topical paromomycin as adjunctive treatment for a recalcitrant cutaneous leishmaniasis wound.
abstract: OBJECTIVE
  Leishmaniasis is a vector borne disease that can cause disease manifestations that range from localized skin ulceration to lethal visceral disease. With increased global travel, cutaneous leishmaniasis (CL) is becoming more common in developed nations. However, current treatment options are limited.
  
  
  METHODS
  We report a 16-year-old female who presented with several non-tender, non-healing CL wounds on her bilateral upper and lower extremities. Ablative fractional laser resurfacing (AFR) was used in conjunction with topical paromomycin via laser-assisted delivery to treat the largest non-healing CL wound on the patient's distal lower extremity.
  
  
  RESULTS
  Upon follow-up after two treatments with AFR, the patient's wound healed completely without evidence of infection and with minimal scarring.
  
  
  CONCLUSIONS
  AFR with laser-assisted delivery of topical paromomycin represents a novel treatment option for resistant, non-healing CL wounds. The technique may prove additionally useful for concurrent mitigation of scarring related to CL.
authors.affiliation: Department of Dermatology, Naval Medical Center, San Diego, California.
authors.forename: Andrew
authors.initials: A
authors.lastname: Basnett
authors.affiliation: Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California.|University of California San Diego School of Medicine, San Diego, California.
authors.forename: Tuyet A
authors.initials: TA
authors.lastname: Nguyen
authors.affiliation: University of California San Diego School of Medicine, San Diego, California.|Division of Pediatric Infectious Disease, Rady Children's Hospital, San Diego, California.
authors.forename: Christopher
authors.initials: C
authors.lastname: Cannavino
authors.affiliation: Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California.|University of California San Diego School of Medicine, San Diego, California.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Krakowski
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D054020:Lasers, Gas / Q000627:therapeutic use*; D016773:Leishmaniasis, Cutaneous / Q000628:therapy*; D010303:Paromomycin / Q000627:therapeutic use*
chemical_list: D000981:Antiprotozoal Agents; D010303:Paromomycin
keywords: adolescent; cutaneous leishmaniasis; laser; laser-assisted delivery; paromomycin; pediatric; surgery; therapy