title: Stereotactic Radiotherapy in the Retreatment of Recurrent Cervical Cancers, Assessment of Toxicity, and Treatment Response: Initial Results and Literature Review.
abstract: To evaluate the role of stereotactic body radiation therapy in the retreatment of locally recurrent cervical cancers. Brachytherapy is the main choice to treat gynecologic cancers.
  
  
  
  Patients with recurrent cervical cancer, previously submitted to radiotherapy, were treated with stereotactic body radiation therapy using a CyberKnife system (Accuray Incorporated, Sunnyvale, California) with a fiducial tracking system.
  
  
  
  From August 2011 to October 2014, 5 patients have been treated. Median age was 81 years (range, 70-84 years). Two patients were diagnosed with adenocarcinoma endometrioid and 3 with squamous cell carcinoma. Toxicity was scored according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. After a median follow-up of 12 months (range, 8-34 months), no severe (>grade 3) acute/late genitourinary or low gastrointestinal toxicity was observed.
  
  
  
  Our preliminary results of stereotactic body radiation therapy "simulating" high dose rate for recurrent cervical cancers confirm a minimal toxicity and an optimal outcome. The stereotactic body radiation therapy is an alternative to high dose rate brachytherapy for gynecologic tumors.
authors.affiliation: Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, Messina, Italy apontoriero@unime.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pontoriero
authors.affiliation: Operative Unit of Radiation Oncology, A.O.U. "G. Martino," Messina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Iatì
authors.affiliation: University School of Medicine, Department of Biomedical Sciences and Morphological and Functional Images, University of Mesina, Messina, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Aiello
authors.affiliation: Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, Messina, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pergolizzi
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D016634:Radiosurgery / Q000379:methods; D011879:Radiotherapy Dosage; D019233:Retreatment / Q000379:methods; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
keywords: CyberKnife; gynecologic cancer; recurrent cervical cancer; stereotactic body radiation therapy