title: Simvastatin Protects Osteoblasts from the Deleterious Effects of the Liquid Milieu of Multiple Myeloma.
abstract: Lytic bone lesions are the main clinical manifestation of multiple myeloma. The intense variety in this cell microenvironment, composed mainly of fibroblasts, osteoblasts, osteoclasts, immune cells and mesenchymal cells, is influenced by the massive presence of neoplastic plasma cells. Studies with statins have reported their action in stimulating the formation and reducing bone resorption. The aim of this study was to verify the in vitro response of human osteoblasts exposed to the supernatant (liquid milieu) of multiple myeloma. The data obtained indicate that simvastatin has positive effects on the growth of osteoblasts and protection against the anti-proliferative effects of multiple myeloma supernatant.
authors.affiliation: State University of Ponta Grossa, Biological and Health Science Multidisciplinary Laboratory, Ponta Grossa, PR, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Jitumori
authors.affiliation: Department of Pharmaceutical Sciences, Universidade Estadual de Ponta Grossa, PR, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Fernandes
authors.affiliation: State University of Ponta Grossa, Biological and Health Science Multidisciplinary Laboratory, Ponta Grossa, PR, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Jitumori
authors.affiliation: State University of Ponta Grossa, Biological and Health Science Multidisciplinary Laboratory, Ponta Grossa, PR, Brazil. gmfavero@uepg.br.
authors.forename: G M
authors.initials: GM
authors.lastname: Favero