title: Synthesis of nanohydrogels based on tragacanth gum biopolymer and investigation of swelling and drug delivery.
abstract: The present article deals with preparation of pH responsive nanohydrogels based on tragacanth gum (TG) biopolymer for drug delivery. The nanohydrogels were prepared using different chemical reagents such as 3-aminopropyltriethoxysilane (APTES) modifier and glyceroldiglycidylether (GDE), polyvinyl alcohol (PVA), and glutaraldehyde (GA) as cross-linkers. The obtained nanohydrogels were characterized using different techniques such as scanning electron microscope (SEM), elemental analysis, FT-IR, zeta sizer and thermogravimetric analysis (TGA). The gel content increased with increasing the cross-linkers contents and reached to a maximum of 90%. The swelling behavior of nanohydrogels was investigated in terms of the effect of pH (2.2, 7.4 and 9), temperature (27, 37 and 60°C), and reaction time (2-24h). Loading of Indomethacin (IND) as a model drug showed dependence on the network structure of nanohydrogels. The total in vitro IND release showed dependence on the network structure of nanohydrogels and was in the range of 50-80% at pH 9 after 24h.
authors.affiliation: Polymer Research Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
authors.forename: Masoomeh
authors.initials: M
authors.lastname: Sadat Hosseini
authors.affiliation: Polymer Research Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Hemmati
authors.affiliation: Polymer Research Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran. Electronic address: ghaemy@umz.ac.ir.
authors.forename: Mousa
authors.initials: M
authors.lastname: Ghaemy
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D001704:Biopolymers / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005976:Glutaral; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000008:administration & dosage; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D053149:Plant Gums / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013816:Thermodynamics; D014144:Tragacanth / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001704:Biopolymers; D004337:Drug Carriers; D020100:Hydrogels; D053149:Plant Gums; D014144:Tragacanth; D005976:Glutaral; D007213:Indomethacin
keywords: Drug delivery; Nanohydrogel; Swelling behavior; Tragacanth gum