title: Emerging malnutrition during hospitalisation independently predicts poor 3-month outcomes after acute stroke: data from a Chinese cohort.
abstract: OBJECTIVE
  Questions exist regarding the causal relationship between malnutrition and stroke outcomes. This study aimed to determine whether nutritional status changes or malnutrition during hospitalisation could predict 3-month outcomes in acute stroke patients.
  
  
  METHODS
  During a 10-month period, patients who suffered their first stroke within 7 days after stroke onset were included in this prospective multi-centre study. The demographic parameters, stroke risk and severity factors, malnutrition risk factors and dysphagia were recorded. Nutritional status was assessed by 3 anthropometric and 3 biochemical indices. Changes in nutritional status were defined by comparing the admission values with the 2-week values. A Modified Rankin Scale score of 3-6 was defined as a poor outcome at the 3-month follow-up. Univariate and multiple logistic regression analyses were used to investigate the power of nutritional status changes in predicting poor patient outcomes.
  
  
  RESULTS
  Data from 760 patients were analysed. Poor outcomes were observed in 264 (34.7%) patients. Malnutrition prevalence was 3.8% at admission and 7.5% after 2-weeks in hospital, which could not predict 3-month outcome. Emerging malnutrition was observed in 36 patients (4.7%) during the 2-week hospitalisation period and independently predicted poor 3-month outcomes after adjusting for confounding factors (odds ratio 1.37, 95% confidence interval 1.03-1.83).
  
  
  CONCLUSIONS
  Emerging malnutrition during hospitalisation independently predicted poor 3-month outcomes in acute stroke patients in this study.
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Anxin
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wei
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Yu
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Shengyun
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.affiliation: Tianjin Medical University General Hospital, Tianjing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Xue
authors.affiliation: Tianjin Medical University General Hospital, Tianjing, China.
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Renji Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Renji Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yu
authors.affiliation: Branch of Shanghai First People's Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Shaoshi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Branch of Shanghai First People's Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Zhenli
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Branch of Shanghai First People's Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Tianheng
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Xia
authors.affiliation: Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Maolin
authors.initials: M
authors.lastname: He
authors.affiliation: Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Hubei General Hospital, Wuhan University, Wuhan, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Hubei General Hospital, Wuhan University, Wuhan, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Ruijin Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Shengdi
authors.initials: S
authors.lastname: Chen
authors.affiliation: Ruijin Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Ruijin Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Guidong
authors.initials: G
authors.lastname: Liu
authors.affiliation: Guangdong General Hospital, Guangzhou, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Guangdong General Hospital, Guangzhou, China.
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Tangshan Worker Hospital, Hebei Medical University, Tangshan, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Ma
authors.affiliation: Tangshan Worker Hospital, Hebei Medical University, Tangshan, China.
authors.forename: Fengqun
authors.initials: F
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authors.affiliation: Nanjing Drum Tower Hospital, Nanjing University Medical School, China, Nanjing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Nanjing Drum Tower Hospital, Nanjing University Medical School, China, Nanjing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.affiliation: Nanjing Drum Tower Hospital, Nanjing University Medical School, China, Nanjing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Disease (NCRC-ND), Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. Email: yongjunwang1962@gmail.com.
authors.forename: Yongjun
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authors.lastname: Wang
mesh_terms: D000368:Aged; D015984:Causality; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000453:epidemiology*; D008875:Middle Aged; D009752:Nutritional Status; D016017:Odds Ratio; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000453:epidemiology*