title: [Campylobacteriosis at the Department of Infectious Diseases of the University Hospital Brno in 2011-2013: a retrospective study].
abstract: OBJECTIVE
  To provide basic clinical, laboratory, and microbiological characteristics of adult patients with campylobacteriosis admitted to the Department of Infectious Diseases University Hospital Brno (UHB), in 2011-2013.
  
  
  METHODS
  A retrospective analysis of clinical and laboratory parameters of 160 patients hospitalized with campylobacteriosis at the Department of Infectious Diseases, UHB from 1 January 2011 to 31 December 2013.
  
  
  RESULTS
  There was no lethality or bacteremia reported in the study group of 160 adult patients (n=160) with campylobacteriosis. A more severe form of the disease with signs of systemic inflammatory response syndrome (SIRS) occurred in 24 patients, i.e. 15% of the study population. Transient mild to moderate leukocytopenia and thrombocytopenia were seen in 16 (10.0%) and 24 patients (15.0%), respectively, and seven patients (4.4%) had bicytopenia. The following factors correlated statistically significantly with the intestinal form of the disease and SIRS: age under 70 years (p=0.037), absence of arterial hypertension (p=0.044), immunosuppressive treatment (p=0.008), leukocyte count in the peripheral blood over 12.0×10(9)/l (p=0.023), and body temperature over 38.0 °C (p<0.001). Antibiotic treatment was used in 96.3% of patients with the intestinal form and in 100.0% of patients with SIRS. The average duration of antibiotic treatment was 8.8 and 9.3 days, respectively. Postantibiotic colitis due to Clostridium difficile occurred in seven patients (4.4%). There were no organ or autoimmune complications observed.
  
  
  CONCLUSIONS
  Campylobacteriosis with SIRS occurs preferentially in persons under 70 years of age. Empirical antibiotic treatment is used too frequently without being adequately deescalated.
authors.forename: P
authors.initials: P
authors.lastname: Polák
authors.forename: M
authors.initials: M
authors.lastname: Vrba
authors.forename: Z
authors.initials: Z
authors.lastname: Bortlíček
authors.forename: J
authors.initials: J
authors.lastname: Juránková
authors.forename: M
authors.initials: M
authors.lastname: Freibergerová
authors.forename: P
authors.initials: P
authors.lastname: Husa
authors.forename: J
authors.initials: J
authors.lastname: Kamelander
authors.forename: M
authors.initials: M
authors.lastname: Dastych
mesh_terms: D000328:Adult; D002169:Campylobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D016360:Clostridioides difficile / Q000235:genetics / Q000302:isolation & purification*; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006760:Hospitalization; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018746:Systemic Inflammatory Response Syndrome / Q000453:epidemiology / Q000382:microbiology
keywords: campylobacteriosis - invasive disease - antibiotic resistance.