title: Enhanced mucosal healing with curcumin in animal oral ulcer model.
abstract: OBJECTIVE
  Oral ulcers are very common and can compromise the quality of life of patients with pain. The objective of this study was to evaluate mucosal healing with curcumin in an animal oral ulcer model.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Twenty New Zealand white rabbits were used. Round filter paper 6 mm in diameter was soaked with 15 μl 50% acetic acid and applied over the upper labial gingiva, creating a uniform circular ulcer. After creation of an oral ulcer, curcumin, the active substance in tumeric, was applied twice over the ulcer in the experimental group but not in the control group. The ulcer area was calculated by maximal (D) and minimal (d) diameter : π × D × d/4. All animals were weighed, and the area was measured on days 0, 7, and 14. On days 7 and 14, half of the animals were sacrificed and gingival specimens were acquired.
  
  
  RESULTS
  Curcumin treatment exhibited accelerated healing such that the gross appearance of the ulcer demonstrated a recognizable difference in wound healing between the curcumin-treated and control groups with time. Weight loss was observed after the creation of oral ulcer in the control group. However, the curcumin-treated group gained weight with time, resulting in a significant weight difference. On day 14, epithelial regeneration was completed in the treated group but incomplete in the control group.
  
  
  CONCLUSIONS
  Topical application of curcumin enhanced the wound-healing process of oral ulcer in the animal model, which implicate that curcumin can be used as an effective and safe medical tool in the treatment of oral ulcer.
  
  
  METHODS
  NA.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Gyeonggi.
authors.forename: Yun-Sung
authors.initials: YS
authors.lastname: Lim
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Seong Keun
authors.initials: SK
authors.lastname: Kwon
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Gyeonggi.
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Gyeonggi.
authors.forename: Chang Gun
authors.initials: CG
authors.lastname: Cho
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Gyeonggi.
authors.forename: Seok-Won
authors.initials: SW
authors.lastname: Park
authors.affiliation: the Department of Internal Medicine, Ilsan Hospital, Dongguk University.|Channelopathy Research Center, Dongguk University College of Medicine, Goyang, Gyeonggi.
authors.forename: Woo Kyung
authors.initials: WK
authors.lastname: Kim
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D003474:Curcumin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology*; D019226:Oral Ulcer / Q000188:drug therapy* / Q000473:pathology; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003474:Curcumin
keywords: Curcumin; mucosa; oral ulcer; wound healing