title: Antimalarial Drugs for the Treatment of Oral Erosive Lichen Planus.
abstract: BACKGROUND
  Treatment of oral erosive lichen planus is considered a therapeutic challenge. Various systemic and topical agents aimed at controlling the symptoms, rather than curing the lesions, have been used with varying results.
  
  
  OBJECTIVE
  To evaluate the response to treatment with antimalarial drugs in patients with oral erosive lichen planus.
  
  
  METHODS
  Eight patients diagnosed with oral erosive lichen planus were treated with antimalarial agents. The first clinical evaluation was made after a month of treatment and then every 2-3 months. Baseline ophthalmologic examinations were performed, and laboratory values were monitored before and during treatment.
  
  
  RESULTS
  All studied patients who had previously been resistant to other treatments responded favorably. Pain relief and reduced erythema and erosions were observed after of a mean of 2.4 months.
  
  
  CONCLUSIONS
  Antimalarials may be useful for the treatment of oral erosive lichen planus. They are easily administered and affordable, with few adverse effects.
authors.affiliation: Department of Dermatology, Instituto Valenciano de Oncologx00ED;a, Valencia, Spain.
authors.forename: Nancy
authors.initials: N
authors.lastname: Rivas-Tolosa
authors.forename: Celia
authors.initials: C
authors.lastname: Requena
authors.forename: Beatriz
authors.initials: B
authors.lastname: Llombart
authors.forename: Rebeca
authors.initials: R
authors.lastname: Alcalá
authors.forename: Carlos
authors.initials: C
authors.lastname: Serra-Guillén
authors.forename: Laura
authors.initials: L
authors.lastname: Calomarde
authors.forename: Eduardo
authors.initials: E
authors.lastname: Nagore
authors.forename: Carlos
authors.initials: C
authors.lastname: Guillén
authors.forename: Onofre
authors.initials: O
authors.lastname: Sanmartín
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000962:Antimalarials / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials