title: Correlation of cadherin-17 protein expression with clinicopathological features and prognosis of patients with sporadic gastric cancer.
abstract: This study aimed to explore the correlations between cadherin-17 (CDH17) protein expression and the clinicopathological features and prognosis of patients with sporadic gastric cancer (GC). Nine relevant studies of 1,960 patients were identified using electronic database searches supplemented with a manual search in strict accordance with inclusion and exclusion criteria. Statistical analyses were conducted using STATA 12.0 statistical software. Relative risks and 95% confidence intervals were determined, and Z test was used to measure the significance of the overall effect size. A total of nine eligible cohort studies were included in this meta-analysis. The expression of CDH17 in patients with diffuse GC was significantly higher than in those with intestinal-type GC. Moreover, the tumor depth of invasion differed significantly between patients with positive CDH17 (CDH17+) and negative CDH17 (CDH17-) GC. However, there were no significant differences between CDH17+ and CDH17- GC patients with respect to tumor node metastasis clinical stages, histological grades, or lymph node metastasis. Despite the differences in invasive depth, there was no significant difference in 5-year survival rates between CDH17+ and CDH17- GC patients. Our meta-analysis provides evidence that CDH17 protein expression may be associated with the development of GC, suggesting that CDH17 is an important biomarker that could be useful for the early diagnosis of GC. However, CDH17 levels do not appear to impact overall survival.
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou, Hebei Province, China.
authors.forename: W
authors.initials: W
authors.lastname: Meng
authors.affiliation: Department of Medical Oncology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China.
authors.forename: T
authors.initials: T
authors.lastname: Gu
authors.affiliation: Department of Medical Oncology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China.
authors.forename: L M
authors.initials: LM
authors.lastname: Gao
authors.affiliation: First Affiliated Hospital, Hebei North University, Zhangjiakou, Hebei Province, China.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Zong
authors.affiliation: Department of Anesthesiology, Guilin Medical University, Guilin, Guangxi Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Meng
authors.affiliation: Department of Medical Oncology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China.
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Fu
authors.affiliation: School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Guo
mesh_terms: D015820:Cadherins / Q000378:metabolism*; D016001:Confidence Intervals; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000378:metabolism*; D011379:Prognosis; D012044:Regression Analysis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
chemical_list: C490584:CDH17 protein, human; D015820:Cadherins; D009363:Neoplasm Proteins