title: RETROSPECTIVE METHOD VALIDATION AND UNCERTAINTY ESTIMATION FOR ACTINIDES DETERMINATION IN EXCRETA BY ALPHA SPECTROMETRY.
abstract: Two essential technical requirements of ISO 17025 guide for accreditation of testing and calibration laboratories are the validation of methods and the estimation of all sources of uncertainty that may affect the analytical result. Bioelimination Laboratory from Radiation Dosimetry Service of CIEMAT (Spain) uses alpha spectrometry to quantify alpha emitters (Pu, Am, Th, U and Cm isotopes) in urine and faecal samples from workers exposed to internal radiation. Therefore and as a step previous to achieving the ISO 17025 accreditation, the laboratory has performed retrospective studies based on the obtained results in the past few years to validate the analytical method. Uncertainty estimation was done identifying and quantifying all the contributions, and finally the overall combined standard uncertainty was calculated.
authors.affiliation: Bioelimination Laboratory, Radiation Dosimetry Service, CIEMAT, Avda. Complutense 40, 28040 Madrid, Spain carolina.hernandez@ciemat.es.
authors.forename: C
authors.initials: C
authors.lastname: Hernández
authors.affiliation: Bioelimination Laboratory, Radiation Dosimetry Service, CIEMAT, Avda. Complutense 40, 28040 Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Sierra
mesh_terms: D000068:Accreditation; D008671:Actinoid Series Elements / Q000032:analysis* / Q000652:urine*; D000512:Alpha Particles; D000576:Americium / Q000652:urine; D002138:Calibration; D003476:Curium / Q000652:urine; D005243:Feces; D006801:Humans; D011005:Plutonium / Q000652:urine; D011786:Quality Control; D011868:Radioisotopes / Q000032:analysis; D011874:Radiometry / Q000295:instrumentation / Q000379:methods*; D012015:Reference Standards; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013910:Thorium / Q000652:urine; D035501:Uncertainty; D014501:Uranium / Q000652:urine; D014556:Urine; D014867:Water
chemical_list: D008671:Actinoid Series Elements; D011868:Radioisotopes; D014867:Water; D014501:Uranium; D011005:Plutonium; D013910:Thorium; D003476:Curium; D000576:Americium