title: Frequency-dependent changes in the amplitude of low-frequency fluctuations in internet gaming disorder.
abstract: Neuroimaging studies have revealed that the task-related functional brain activities are impaired in internet gaming disorder (IGD) subjects. However, little is known about the alternations in spontaneous brain activities about them. Recent studies have proposed that the brain activities of different frequency ranges are generated by different nervous activities and have different physiological and psychological functions. Thus, in this study, we set to explore the spontaneous brain activities in IGD subjects by measuring the fractional amplitude of low-frequency fluctuation (fALFF), to investigate band-specific changes of resting-state fALFF. We subdivided the frequency range into five bands based on literatures. Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus. Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus. Those brain regions are proved related to the executive function and decision-making. These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.
authors.affiliation: Department of Psychology, Zhejiang Normal University, Jinhua China ; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.affiliation: Cognitive and Brain Disease Research Center, Hangzhou Normal University, Hangzhou China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou China.
authors.forename: Xize
authors.initials: X
authors.lastname: Jia
authors.affiliation: Cognitive and Brain Disease Research Center, Hangzhou Normal University, Hangzhou China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zang
authors.affiliation: Department of Psychology, Zhejiang Normal University, Jinhua China ; Institute of Psychological Research, Zhejiang Normal University, Jinhua China.
authors.forename: Guangheng
authors.initials: G
authors.lastname: Dong
keywords: amplitude of low-frequency fluctuation; internet gaming disorder; resting-state functional magnetic resonance imaging