title: Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon.
abstract: Presbyopia is a common age-related condition that prevents people from focusing on near objects. The etiology of presbyopia continues to be debated, but the end effect of all postulated mechanisms is the lack of deformation of the human lens. Using our understanding of the biomechanical properties of the natural human lens, we created a unique accommodating intraocular lens. Although this lens can be used for lenticular disease such as myopia and hyperoperopia, this study addresses the needs of cataract patients with presbyopia.
  
  
  
  The lens was implanted into presbyopic human cadaver eyes. Focal length of the lens was measured with simulated muscle contraction. Lens dimensions were measured using artificial tissue and a finite-element analysis (FEA) to simulate accommodation. Lens power was measured at various fill volumes. Accelerated soak testing for an equivalent of 7.4 years was performed and lens weight and optical transmittance were measured.
  
  
  
  Previously presbyopic human eyes were able to accommodate between 2.0 and 7.4 diopters after lens implantation. FEA and lens measurements demonstrated a change in curvature of the anterior and posterior portions of the lens during accommodation. After accelerated aging, lens weight remained unchanged and optical transmission was 96%. Lens power increased with fill volume.
  
  
  
  A deformable liquid lens reversed presbyopia, can be individualized by optically adjusting for each patient, is stable for long periods of time, and is compatible with minimally invasive surgical techniques.
  
  
  
  A deformable liquid-filled lens can significantly improve accommodation over the presbyopic natural lens.
authors.forename: Charles M T
authors.initials: CM
authors.lastname: DeBoer
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Lee
authors.forename: Brooks P
authors.initials: BP
authors.lastname: Wheelan
authors.forename: Craig
authors.initials: C
authors.lastname: Cable
authors.forename: Wendian
authors.initials: W
authors.lastname: Shi
authors.forename: Yu-Chong
authors.initials: YC
authors.lastname: Tai
authors.forename: Mark S
authors.initials: MS
authors.lastname: Humayun
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology*; D032701:Biomimetics / Q000295:instrumentation*; D006801:Humans; D007910:Lenses, Intraocular; D055617:Micro-Electrical-Mechanical Systems; D008954:Models, Biological; D055095:Optics and Photonics / Q000295:instrumentation*; D011305:Presbyopia; D011474:Prosthesis Design