title: Impedance matching network for high frequency ultrasonic transducer for cellular applications.
abstract: An approach for the design of an impedance matching network (IMN) for high frequency ultrasonic transducers with large apertures based on impedance analysis for cellular applications is presented in this paper. The main objectives were to maximize energy transmission from the excitation source to the ultrasonic transducers for cell manipulation and to achieve low input parameters for the safe operation of an ultrasonic transducer because the piezoelectric material in high frequency ultrasonic transducers is prone to breakage due to its being extremely thin. Two ultrasonic transducers, which were made of lithium niobate single crystal with the thickness of 15 μm, having apertures of 4.3 mm (fnumber=1.23) and 2.6mm (fnumber=0.75) were tested. L-type IMN was selected for high sensitivity and compact design of the ultrasonic transducers. The target center frequency was chosen as the frequency where the electrical admittance (|Y|) and phase angle (θz) from impedance analysis was maximal and zero, respectively. The reference center frequency and reference echo magnitude were selected as the center frequency and echo magnitude, measured by pulse-echo testing, of the ultrasonic transducer without IMN. Initial component values and topology of IMN were determined using the Smith chart, and pulse-echo testing was analyzed to verify the performance of the ultrasonic transducers with and without IMN. After several iterations between changing component values and topology of IMN, and pulse-echo measurement of the ultrasonic transducer with IMN, optimized component values and topology of IMN were chosen when the measured center frequency from pulse-echo testing was comparable to the target frequency, and the measured echo magnitude was at least 30% larger than the reference echo magnitude. Performance of an ultrasonic transducer with and without IMN was tested by observing a tangible dent on the surface of a plastic petridish and single cell response after an acoustic pulse was applied on a target cell.
authors.affiliation: Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Min Gon
authors.initials: MG
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: sangpil@usc.edu.
authors.forename: Sangpil
authors.initials: S
authors.lastname: Yoon
authors.affiliation: Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Hyung Ham
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: K Kirk
authors.initials: KK
authors.lastname: Shung
mesh_terms: D002469:Cell Separation / Q000295:instrumentation*; D058948:Cell Tracking / Q000295:instrumentation*; D017076:Computer-Aided Design; D017097:Electric Impedance; D004582:Electronics, Medical; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation*; D008846:Micromanipulation / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers; D014463:Ultrasonography / Q000295:instrumentation*
keywords: Impedance analysis; L-type impedance matching network; Large aperture high frequency ultrasonic transducer; Optimization of impedance matching network; Single-cell application