title: Left Ventricular Hypertrophy Phenotype in Childhood-Onset Essential Hypertension.
abstract: The aim of this study was to determine the risk factors associated with left ventricular (LV) hypertrophy (LVH) among 89 untreated children with primary hypertension. Clinic hypertension was confirmed by 24-hour ambulatory blood pressure (BP) monitoring. LV mass (LVM) index was calculated as LVM (g)/height (m)(2.7) and LVH was defined as LVM index >95th percentile. Children with (n=32) and without (n=57) LVH were compared. Both obesity and systolic BP were independently associated with LVH, with a higher contribution by body mass index. Obesity contributed significantly, with a nearly nine-fold increased risk of LVH. There was evidence of effect modification by the presence or absence of obesity on the relationship between systolic BP and LVH, whereby the relationship existed mainly in nonobese rather than obese children. Hence, to achieve reversal of LVH, clinicians should take into account both BP control and weight management.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Children's Memorial Hermann Hospital, The University of Texas Health Science Center, Houston, TX.|Division of Pediatric Nephrology, Department of Pediatrics, Children's Memorial Hermann Hospital, The University of Texas Health Science Center, Houston, TX.
authors.forename: Monesha
authors.initials: M
authors.lastname: Gupta-Malhotra
authors.affiliation: Department of Pediatrics, Pediatric Research Center, The University of Texas Health Science Center, Houston, TX.
authors.forename: Syed Shahrukh
authors.initials: SS
authors.lastname: Hashmi
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Children's Memorial Hermann Hospital, The University of Texas Health Science Center, Houston, TX.
authors.forename: Tim
authors.initials: T
authors.lastname: Poffenbarger
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Children's Hospital of Arkansas, University of Arkansas for Medical Sciences, Little Rock, AR.
authors.forename: Karen
authors.initials: K
authors.lastname: McNiece-Redwine
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002648:Child; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology*; D008297:Male; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors