title: An Overview and Update of Chronic Myeloid Leukemia for Primary Care Physicians.
abstract: Chronic myeloid leukemia (CML) accounts for approximately 15% of adult leukemias. Forty percent of patients with CML are asymptomatic, in whom the disease is detected solely based on laboratory abnormalities. Since the introduction of tyrosine kinase inhibitor therapy in 2001, CML has become a chronic disease for the majority of patients. Primary care physicians may be the first to recognize a new diagnosis of CML. In patients with known CML, the primary care physician may be the first to detect disease progression or adverse effects to therapy. This article provides an overview of the clinical presentation, diagnostic approach, and treatment considerations of CML.
authors.affiliation: College of Medicine, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Austin
authors.initials: A
authors.lastname: Granatowicz
authors.affiliation: Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California (USC)/Norris Cancer Center, USC University Hospital, Los Angeles, USA.
authors.forename: Caroline I
authors.initials: CI
authors.lastname: Piatek
authors.affiliation: Department of Pathology, Veterans Affairs West Los Angeles Medical Center, Los Angeles, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Moschiano
authors.affiliation: Consultant Adult Hematology/BMT, Princess Noorah Oncology Center, Jeddah, Kingdom of Saudi Arabia.
authors.forename: Ihab
authors.initials: I
authors.lastname: El-Hemaidi
authors.affiliation: Division of General Internal Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Joel D
authors.initials: JD
authors.lastname: Armitage
authors.affiliation: Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California (USC)/Norris Cancer Center, USC University Hospital, Los Angeles, USA.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Akhtari
keywords: Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Primary Health Care