title: The association between maternal dietary micronutrient intake and neonatal anthropometry - secondary analysis from the ROLO study.
abstract: BACKGROUND
  Micronutrients are necessary for fetal growth. However increasingly pregnant women are nutritionally replete and little is known about the effect of maternal micronutrient intakes on fetal adiposity in mothers with increased BMI. The aim of this study was to examine the association of maternal dietary micronutrient intake with neonatal size and adiposity in a cohort at risk of macrosomia.
  
  
  METHODS
  This was a cohort analysis of 554 infants from the ROLO study. Three day food diaries from each trimester were collected. Neonatal weight, length, circumferences and skinfold thicknesses were measured at birth. Multiple linear regression was used to identify associations between micronutrient intakes and neonatal anthropometry.
  
  
  RESULTS
  Birthweight was negatively associated with maternal trimester 3 vitamin D intake and positively associated with trimester 3 vitamin B12 intake R2adj 19.8% (F = 13.19, p <0.001). Birth length was positively associated with trimester 3 magnesium intake R2adj 12.9% (F = 8.06, p <0.001). In terms of neonatal central adiposity; abdominal circumference was positively associated with maternal trimester 3 retinol intake and negatively associated with trimester 3 vitamin E and selenium intake R2adj 11.9% (F = 2.93, p = 0.002), waist:length ratio was negatively associated with trimester 3 magnesium intake R2adj 20.1% (F = 3.92, p <0.001) and subscapular:triceps skinfold ratio was negatively associated with trimester 1 selenium intake R2adj7.2% (F = 2.00, p = 0.047).
  
  
  CONCLUSIONS
  Maternal micronutrient intake was associated with neonatal anthropometry even in women not at risk of malnutrition. Further research is necessary to determine optimal micronutrient intake in overweight and obese pregnant women.
  
  
  BACKGROUND
  Current Controlled Trials ISRCTN54392969.
authors.affiliation: UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Horan
authors.affiliation: UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland.
authors.forename: Ciara A
authors.initials: CA
authors.lastname: McGowan
authors.affiliation: UCD Institute of Food and Health, University College Dublin, Dublin 4, Ireland.
authors.forename: Eileen R
authors.initials: ER
authors.lastname: Gibney
authors.affiliation: UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland.
authors.forename: Jean M
authors.initials: JM
authors.lastname: Donnelly
authors.affiliation: UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland. fionnuala.mcauliffe@ucd.ie.
authors.forename: Fionnuala M
authors.initials: FM
authors.lastname: McAuliffe
mesh_terms: D050154:Adiposity / Q000502:physiology; D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D015331:Cohort Studies; D004032:Diet / Q000706:statistics & numerical data*; D015930:Diet Records; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D006801:Humans; D018977:Micronutrients / Q000008:administration & dosage*; D009035:Mothers; D011247:Pregnancy
chemical_list: D018977:Micronutrients