title: Consensus Paper: Cerebellar Development.
abstract: The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.
authors.affiliation: Department of Neuroscience Rita Levi Montalcini, University of Turin, via Cherasco 15, 10026, Turin, Italy. ketty.leto@unito.it.|Neuroscience Institute Cavalieri-Ottolenghi, University of Turin, Regione Gonzole 10, 10043, Orbassano, Torino, Italy. ketty.leto@unito.it.
authors.forename: Ketty
authors.initials: K
authors.lastname: Leto
authors.affiliation: Departments of Pathology & Immunology and Neuroscience, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX, 77030, USA.
authors.forename: Marife
authors.initials: M
authors.lastname: Arancillo
authors.affiliation: Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
authors.forename: Esther B E
authors.initials: EB
authors.lastname: Becker
authors.affiliation: Department of Neuroscience Rita Levi Montalcini, University of Turin, via Cherasco 15, 10026, Turin, Italy.|Neuroscience Institute Cavalieri-Ottolenghi, University of Turin, Regione Gonzole 10, 10043, Orbassano, Torino, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Buffo
authors.affiliation: Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4114 MRB III, Nashville, TN, 37232, USA.
authors.forename: Chin
authors.initials: C
authors.lastname: Chiang
authors.affiliation: Department of Microbiology and Physiological Systems and Program in Neuroscience, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605-2324, USA.
authors.forename: Baojin
authors.initials: B
authors.lastname: Ding
authors.affiliation: Seattle Children's Research Institute, Center for Integrative Brain Research, Seattle, WA, USA.|Department of Pediatrics, Genetics Division, University of Washington, Seattle, WA, USA.
authors.forename: William B
authors.initials: WB
authors.lastname: Dobyns
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, Institut de Biologie Paris Seine, France, 75005, Paris, France.|Centre National de la Recherche Scientifique, CNRS, UMR8246, INSERM U1130, Neuroscience Paris Seine, France, 75005, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dusart
authors.affiliation: Seattle Children's Research Institute, Center for Integrative Brain Research, Seattle, WA, USA.
authors.forename: Parthiv
authors.initials: P
authors.lastname: Haldipur
authors.affiliation: Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY, 10065, USA.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Hatten
authors.affiliation: Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Hoshino
authors.affiliation: Developmental Biology Program, Sloan Kettering Institute, New York, NY, 10065, USA.
authors.forename: Alexandra L
authors.initials: AL
authors.lastname: Joyner
authors.affiliation: Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kano
authors.affiliation: Department of Microbiology and Physiological Systems and Program in Neuroscience, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605-2324, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Kilpatrick
authors.affiliation: Department of Integrative Physiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Koibuchi
authors.affiliation: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
authors.forename: Silvia
authors.initials: S
authors.lastname: Marino
authors.affiliation: Department Human Anatomy, IMIB-Arrixaca, University of Murcia, Murcia, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Martinez
authors.affiliation: Seattle Children's Research Institute, Center for Integrative Brain Research, Seattle, WA, USA.
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Millen
authors.affiliation: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
authors.forename: Thomas O
authors.initials: TO
authors.lastname: Millner
authors.affiliation: Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Takaki
authors.initials: T
authors.lastname: Miyata
authors.affiliation: Department of Neuroscience Rita Levi Montalcini, University of Turin, via Cherasco 15, 10026, Turin, Italy.|Neuroscience Institute Cavalieri-Ottolenghi, University of Turin, Regione Gonzole 10, 10043, Orbassano, Torino, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Parmigiani
authors.affiliation: Anatomie und Zellbiologie, Anatomisches Institut, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Schilling
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Sekerková
authors.affiliation: Departments of Pathology & Immunology and Neuroscience, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX, 77030, USA.
authors.forename: Roy V
authors.initials: RV
authors.lastname: Sillitoe
authors.affiliation: Institut de la Vision, UPMC Université de Paris 06, Paris, 75012, France.
authors.forename: Constantino
authors.initials: C
authors.lastname: Sotelo
authors.affiliation: Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Uesaka
authors.affiliation: Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Wefers
authors.affiliation: MRC Centre for Developmental Neurobiology, King's College London, London, UK.
authors.forename: Richard J T
authors.initials: RJ
authors.lastname: Wingate
authors.affiliation: Department of Cell Biology & Anatomy and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, T2N 4NI, AB, Canada.
authors.forename: Richard
authors.initials: R
authors.lastname: Hawkes
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000166:cytology / Q000196:embryology* / Q000254:growth & development* / Q000503:physiopathology; D006801:Humans; D055495:Neurogenesis / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology
keywords: Cerebellum; Differentiation; Progenitors; Purkinje cells; Specification