title: Improved simultaneous estimation of tracer kinetic models with artificial immune network based optimization method.
abstract: Tracer kinetic modeling (TKM) is a promising quantitative method for physiological and biochemical processes in vivo. In this paper, we investigated the applications of an immune-inspired method to better address the issues of Simultaneous Estimation (SIME) of TKM with multimodal optimization. Experiments of dynamic FDG PET imaging experiments and simulation studies were carried out. The proposed artificial immune network (TKM_AIN) shows more scalable and effective when compared with the gradient-based Marquardt-Levenberg algorithm and the scholastic-based simulated annealing method.
authors.affiliation: Information Center, Affiliated Hospital of Jiangnan University, No. 200, Huihe Road, Wuxi 214062, China. Electronic address: liuli_sytu@hotmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.affiliation: Key Laboratory of Nuclear Medicine, Ministry of Health, No. 20, Qianrong Road, Wuxi 214063, China.
authors.forename: H
authors.initials: H
authors.lastname: Ding
authors.affiliation: Key Laboratory of Nuclear Medicine, Ministry of Health, No. 20, Qianrong Road, Wuxi 214063, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Huang
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D007700:Kinetics; D051379:Mice; D008813:Mice, Inbred ICR; D008954:Models, Biological; D018448:Models, Immunological; D016571:Neural Networks, Computer; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D010091:Oximes / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography / Q000379:methods / Q000706:statistics & numerical data; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D013269:Stochastic Processes
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C060156:technetium Tc 99m teboroxime
keywords: Artificial immune network; Compartment model; Dynamic PET; Parameter estimation; Tracer kinetic modeling