title: Current understanding of the neurobiology of major depressive disorder.
abstract: Depression is highly prevalent worldwide and associated with significant morbidity and mortality. Approximately 340 million people worldwide suffer from depression at any given time. Based on estimates from the World Health Organization (WHO), depression is responsible for the greatest proportion of burden associated with non-fatal health outcomes and accounts for approximately 12% total years lived with disability. Probably no single risk factor can be completely isolated in major depressive disorder (MDD), as interactions between many sources of vulnerability are the most likely explanation. Buttressing the identification of grief, demoralization, hopelessness and styles of psychological coping of the depressed patient are vital, ongoing scientific developments that flow from an increased understanding of this interplay amongst the immune system, endocrine system and brain. The rapidly accumulating body of neurobiological knowledge has catalyzed fundamental changes in how we conceptualize depressive symptoms and has important implications regarding the treatment and even prevention of depressive symptoms in patients.
authors.affiliation: University of Medicine and Pharmacy of Craiova, Romania; victor_gheorman1@yahoo.com.
authors.forename: Anca Livia
authors.initials: AL
authors.lastname: Chiriţă
authors.forename: Victor
authors.initials: V
authors.lastname: Gheorman
authors.forename: Dan
authors.initials: D
authors.lastname: Bondari
authors.forename: Ion
authors.initials: I
authors.lastname: Rogoveanu
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology* / Q000517:prevention & control; D004644:Emotions; D004703:Endocrine System; D005786:Gene Expression Regulation; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D007107:Immune System; D008959:Models, Neurological; D009479:Neuropeptides / Q000737:chemistry; D018377:Neurotransmitter Agents / Q000378:metabolism; D012307:Risk Factors; D013315:Stress, Psychological
chemical_list: D009479:Neuropeptides; D018377:Neurotransmitter Agents