title: Hormonal determinants of erectile dysfunction and lower urinary tract symptoms in middle-aged and elderly men with prediabetes.
abstract: OBJECTIVE
  Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) are common in diabetic men. The aim of this study was to investigate hormonal determinants, the prevalence and severity of ED and LUTS in middle-aged and elderly men with prediabetes (PD).
  
  
  METHODS
  We investigated 176 men with PD and 184 healthy peers. PD was defined according American Diabetes Association. ED according IIEF scale and LUTS according IPSS scale were assessed. Total testosterone (TT), calculated free testosterone (cFT), dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor 1 (IGF-1) were measured.
  
  
  RESULTS
  The prevalence of ED in patients with PD was higher than in control group (30 versus 24%) as well as the prevalence and severity of ED and LUTS in elderly (60-80 years) and middle-aged (40-59 years) men with PD was higher than in healthy peers. In middle-aged pre-diabetic men, the more severe LUTS symptoms were associated with low TT and DHEAS, while in elderly men with low cFT and DHEAS. The higher prevalence of ED in middle-aged men with PD was associated with cFT and DHEAS, while in elderly pre-diabetic men with TT and IGF-1.
  
  
  CONCLUSIONS
  The prevalence and severity of LUTS and ED symptoms were higher in pre-diabetic men than in healthy peers. Hormonal determinants of these symptoms are different in middle-aged and elderly patients with PD.
authors.affiliation: a Department of Internal Diseases , Diabetology and Endocrinology, Medical University of Warsaw Poland and.
authors.forename: Michał
authors.initials: M
authors.lastname: Rabijewski
authors.affiliation: b Department of Endocrinology , Medical Centre for Postgraduate Education , Warsaw , Poland.
authors.forename: Lucyna
authors.initials: L
authors.lastname: Papierska
authors.affiliation: a Department of Internal Diseases , Diabetology and Endocrinology, Medical University of Warsaw Poland and.
authors.forename: Roman
authors.initials: R
authors.lastname: Kuczerowski
authors.affiliation: a Department of Internal Diseases , Diabetology and Endocrinology, Medical University of Warsaw Poland and.
authors.forename: Paweł
authors.initials: P
authors.lastname: Piątkiewicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D007172:Erectile Dysfunction / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D059411:Lower Urinary Tract Symptoms / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000150:complications*; D015995:Prevalence
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: Anabolic hormones; erectile dysfunctions; low urinary tract symptoms; prediabetes