title: Antioxidant, antifungal and antiviral activities of chitosan from the larvae of housefly, Musca domestica L.
abstract: Antioxidant activity of the chitosan from the larvae of Musca domestica L. was evaluated in two different reactive oxygen species assays, and inhibitory effects against seven fungi were also tested. The results showed that the chitosan had scavenging activity for hydroxyl and superoxide radicals which were similar to that of ascorbic acid. Also the chitosan exhibited excellent antifungal activity, especially in the low concentration, it could significantly inhibit the growth of Rhizopus stolonifer. Besides, antiviral results demonstrated that the chitosan could effectively inhibit the infection of AcMNPV and BmNPV. These results suggested that the chitosan from the larvae of housefly could be effectively used as a natural antioxidant to protect the human body from free radicals and retard the progress of many chronic diseases. Furthermore, the chitosan with antiviral and antifungal activity might provide useful information for antiviral breeding technology of economic insect and development of plant pathological control.
authors.affiliation: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Huazhong Normal University, Wuhan 430079, PR China; Key Laboratory of Insect Resource Utilization & Sustainable Pest Management of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ai
authors.affiliation: Key Laboratory of Insect Resource Utilization & Sustainable Pest Management of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
authors.forename: Furong
authors.initials: F
authors.lastname: Wang
authors.affiliation: Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Huazhong Normal University, Wuhan 430079, PR China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Key Laboratory of Insect Resource Utilization & Sustainable Pest Management of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Key Laboratory of Insect Resource Utilization & Sustainable Pest Management of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address: ccnuaihui@yahoo.com.cn.
authors.forename: Chaoliang
authors.initials: C
authors.lastname: Lei
mesh_terms: D000818:Animals; D000935:Antifungal Agents; D000975:Antioxidants; D000998:Antiviral Agents; D048271:Chitosan / Q000737:chemistry*; D006793:Houseflies / Q000737:chemistry*; D007814:Larva / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D000998:Antiviral Agents; D048271:Chitosan
keywords: Antifungal activity; Antioxidant activity; Antiviral activity; Chitosan; Musca domestica L.