title: Correlations between forced oscillation technique parameters and pulmonary densitovolumetry values in patients with acromegaly.
abstract: The aims of this study were to evaluate the forced oscillation technique (FOT) and pulmonary densitovolumetry in acromegalic patients and to examine the correlations between these findings. In this cross-sectional study, 29 non-smoking acromegalic patients and 17 paired controls were subjected to the FOT and quantification of lung volume using multidetector computed tomography (Q-MDCT). Compared with the controls, the acromegalic patients had a higher value for resonance frequency [15.3 (10.9-19.7) vs 11.4 (9.05-17.6) Hz, P=0.023] and a lower value for mean reactance [0.32 (0.21-0.64) vs 0.49 (0.34-0.96) cm H2O/L/s2, P=0.005]. In inspiratory Q-MDCT, the acromegalic patients had higher percentages of total lung volume (TLV) for nonaerated and poorly aerated areas [0.42% (0.30-0.51%) vs 0.25% (0.20-0.32%), P=0.039 and 3.25% (2.48-3.46%) vs 1.70% (1.45-2.15%), P=0.001, respectively]. Furthermore, the acromegalic patients had higher values for total lung mass in both inspiratory and expiratory Q-MDCT [821 (635-923) vs 696 (599-769) g, P=0.021 and 844 (650-945) vs 637 (536-736) g, P=0.009, respectively]. In inspiratory Q-MDCT, TLV showed significant correlations with all FOT parameters. The TLV of hyperaerated areas showed significant correlations with intercept resistance (rs=-0.602, P<0.001) and mean resistance (rs=-0.580, P<0.001). These data showed that acromegalic patients have increased amounts of lung tissue as well as nonaerated and poorly aerated areas. Functionally, there was a loss of homogeneity of the respiratory system. Moreover, there were correlations between the structural and functional findings of the respiratory system, consistent with the pathophysiology of the disease.
authors.affiliation: Programa de Pós-Graduação em Ciências Médicas, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: G B
authors.initials: GB
authors.lastname: Camilo
authors.affiliation: Laboratório de Fisiologia da Respiração, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: A R S
authors.initials: AR
authors.lastname: Carvalho
authors.affiliation: Programa de Pós-Graduação em Ciências Médicas, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: D C
authors.initials: DC
authors.lastname: Machado
authors.affiliation: Programa de Pós-Graduação em Ciências Médicas, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: R
authors.initials: R
authors.lastname: Mogami
authors.affiliation: Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, RJ, BR.
authors.forename: L
authors.initials: L
authors.lastname: Kasuki
authors.affiliation: Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, RJ, BR.
authors.forename: M R
authors.initials: MR
authors.lastname: Gadelha
authors.affiliation: Programa de Pós-Graduação em Ciências Médicas, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: P L
authors.initials: PL
authors.lastname: Melo
authors.affiliation: Programa de Pós-Graduação em Ciências Médicas, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BR.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lopes
mesh_terms: D000172:Acromegaly / Q000503:physiopathology / Q000628:therapy*; D000328:Adult; D016022:Case-Control Studies; D035641:Chest Wall Oscillation; D003430:Cross-Sectional Studies; D003720:Densitometry; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology*; D008170:Lung Compliance; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D018709:Statistics, Nonparametric
chemical_list: D019382:Human Growth Hormone