title: The Outcome of Severe Internalizing and Disruptive Disorders from Preschool into Adolescence:A Follow-up Study.
abstract: OBJECTIVE
  In this study we aimed to examine the outcome of children's severe psychiatric disorders from preschool into later childhood and adolescence.
  
  
  METHODS
  Forty preschool children (28 boys and 12 girls) treated in a tertiary referral mental health center, evaluated at admission and 5.5 ± 1.2 years thereafter.
  
  
  RESULTS
  Seven (58.3%) children diagnosed with internalizing disorders at baseline were free of any psychiatric diagnosis at follow-up (p=0.02). Conversely, only one child (8.3%) diagnosed with comorbid disruptive-internalizing disorders at baseline was free of any psychiatric disorder at follow-up (p=1.0). Seven (43.7%) children diagnosed with disruptive disorders at baseline were free of psychiatric diagnoses at follow-up (p=0.02).
  
  
  CONCLUSIONS
  The small sample size and naturalistic nature of the study.
  
  
  CONCLUSIONS
  The trajectories of severe psychiatric disorders at preschool years are similar to those reported in community samples and differ according to the baseline diagnosis. Children with internalizing disorders show a much better recovery rate than those with comorbid disruptive and internalizing disorders.
authors.affiliation: Division of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tikva, Israel.
authors.forename: Sara
authors.initials: S
authors.lastname: Spitzer
authors.affiliation: Division of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tikva, Israel.
authors.forename: Ornit
authors.initials: O
authors.lastname: Freudenstein
authors.affiliation: Division of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Miriam
authors.initials: M
authors.lastname: Peskin
authors.affiliation: Division of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tikva, Israel.
authors.forename: Sam
authors.initials: S
authors.lastname: Tyano
authors.affiliation: Division of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tikva, Israel.
authors.forename: Assaf
authors.initials: A
authors.lastname: Shrira
authors.affiliation: Division of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tikva, Israel.
authors.forename: Tova
authors.initials: T
authors.lastname: Pearlson
authors.affiliation: Division of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tikva, Israel.
authors.forename: Aviad
authors.initials: A
authors.lastname: Eilam
authors.affiliation: Division of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Gil
authors.initials: G
authors.lastname: Zalsman
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel The Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry, Stanford University, California, U.S.A.
authors.forename: Tamar
authors.initials: T
authors.lastname: Green
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel The Child Psychiatry Department, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Doron
authors.initials: D
authors.lastname: Gothelf
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D041923:Adolescent Development; D002648:Child; D002652:Child Behavior / Q000523:psychology*; D002657:Child Development; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000523:psychology*