title: Induced pluripotent stem cells for cardiovascular disease: from product-focused disease modeling to process-focused disease discovery.
abstract: Induced pluripotent stem (iPS) cell technology offers an unprecedented opportunity to study patient-specific disease. This biotechnology platform enables recapitulation of individualized disease signatures in a dish through differentiation of patient-derived iPS cells. Beyond disease modeling, the in vitro process of differentiation toward genuine patient tissue offers a blueprint to inform disease etiology and molecular pathogenesis. Here, we highlight recent advances in patient-specific cardiac disease modeling and outline the future promise of iPS cell-based disease discovery applications.
authors.affiliation: Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.|Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA.|Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Campbell
authors.affiliation: Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.|Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA.|Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.|Department of Medical Genetics, Mayo Clinic, Rochester, MN, USA.
authors.forename: Andre
authors.initials: A
authors.lastname: Terzic
authors.affiliation: Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.|Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA.|Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.|Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.|Center for Transplantation & Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.|Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Nelson
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000379:methods; D002318:Cardiovascular Diseases / Q000628:therapy*; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D004195:Disease Models, Animal; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D010641:Phenotype; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods
keywords: cardiomyocyte; cardiomyopathy; channelopathy; disease discovery; disease modeling; disease pathogenesis; induced pluripotent-stem cell; regenerative medicine