title: p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.
abstract: p62/SQSTM1 is a stress-inducible cellular protein that is conserved among metazoans but not in plants and fungi. p62/SQSTM1 has multiple domains that mediate its interactions with various binding partners and it serves as a signaling hub for diverse cellular events such as amino acid sensing and the oxidative stress response. In addition, p62/SQSTM1 functions as a selective autophagy receptor for degradation of ubiqutinated substrates. In the present review, we describe the current knowledge about p62 with regard to mammalian target of rapamycin complex 1 activation, the Keap1-Nrf2 pathway and selective autophagy.
authors.affiliation: Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Katsuragi
authors.affiliation: Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ichimura
authors.affiliation: Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Komatsu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001343:Autophagy; D004789:Enzyme Activation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000819:agonists / Q000378:metabolism; D000072019:Kelch-Like ECH-Associated Protein 1; D000076222:Mechanistic Target of Rapamycin Complex 1; D008954:Models, Biological; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000819:agonists / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000819:agonists / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs; D000071456:Sequestosome-1 Protein; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D047908:Intracellular Signaling Peptides and Proteins; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1; D046912:Multiprotein Complexes; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases
keywords: Keap1-Nrf2 system; mTORC1; p62/Sqstm1; selective autophagy; ubiquitination