title: Influence of GSTM1, GSTT1, and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk.
abstract: OBJECTIVE
  Diabetic neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). Genetic susceptibility and oxidative stress may play a role in the appearance of T2DM and diabetic neuropathy. We investigated the relation between polymorphism in genes related to oxidative stress such as GSTM1, GSTT1, and GSTP1 and the presence of T2DM and diabetic neuropathy (DN).
  
  
  METHODS
  Samples were collected from 84 patients with T2DM (42 patients with DN and 42 patients without DN) and 98 healthy controls and genotyped by using polymerase chain reaction and restriction fragment length polymorphism method.
  
  
  RESULTS
  GSTP1 Ile105Val polymorphism was associated with the risk of developing T2DM (p = 0.05) but not with the risk of developing DN in diabetic cases. GSTM1 and GSTT1 gene polymorphisms were associated with neither the risk of developing T2DM nor the risk of DN occurrence in diabetic patients. No association was observed between the patients with T2DM and DSPN (diabetic sensorimotor peripheral neuropathy) and T2DM without DSPN regarding investigated polymorphism.
  
  
  CONCLUSIONS
  Our data suggest that GSTP1 gene polymorphisms may contribute to the development of T2DM in Romanian population. GSTM1, GSTT1, and GSTP1 gene polymorphisms are not associated with susceptibility of developing diabetic neuropathy in T2DM patients.
authors.affiliation: Department of Pathophysiology, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
authors.forename: Adina
authors.initials: A
authors.lastname: Stoian
authors.affiliation: Department of Medical Genetics, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bănescu
authors.affiliation: Department of Neurology, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
authors.forename: Rodica Ioana
authors.initials: RI
authors.lastname: Bălaşa
authors.affiliation: Department of Neurology, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
authors.forename: Anca
authors.initials: A
authors.lastname: Moţăţăianu
authors.affiliation: Intensive Care Unit, Mureș County Hospital, Bernády György 6, 540000 Tîrgu Mureş, Romania.
authors.forename: Mircea
authors.initials: M
authors.lastname: Stoian
authors.affiliation: Department of Medical Genetics, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
authors.forename: Valeriu G
authors.initials: VG
authors.lastname: Moldovan
authors.affiliation: Department of Epidemiology, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
authors.forename: Septimiu
authors.initials: S
authors.lastname: Voidăzan
authors.affiliation: Department of Laboratory Medicine, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
authors.forename: Minodora
authors.initials: M
authors.lastname: Dobreanu
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003929:Diabetic Neuropathies / Q000235:genetics*; D005260:Female; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human