title: Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.
authors.affiliation: Health - Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft m.b.H., Graz, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Dragatin
authors.affiliation: Novartis Institutes for BioMedical Research, Basel, Switzerland.
authors.forename: Florine
authors.initials: F
authors.lastname: Polus
authors.affiliation: Health - Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft m.b.H., Graz, Austria.
authors.forename: Manfred
authors.initials: M
authors.lastname: Bodenlenz
authors.affiliation: Novartis Institutes for BioMedical Research, Basel, Switzerland.
authors.forename: Claudio
authors.initials: C
authors.lastname: Calonder
authors.affiliation: Department of General Dermatology, Medical University of Graz, Graz, Austria.
authors.forename: Birgit
authors.initials: B
authors.lastname: Aigner
authors.affiliation: Health - Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft m.b.H., Graz, Austria.
authors.forename: Katrin Irene
authors.initials: KI
authors.lastname: Tiffner
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Julia Katharina
authors.initials: JK
authors.lastname: Mader
authors.affiliation: Health - Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft m.b.H., Graz, Austria.
authors.forename: Maria
authors.initials: M
authors.lastname: Ratzer
authors.affiliation: Novartis Institutes for BioMedical Research, Basel, Switzerland.
authors.forename: Ralph
authors.initials: R
authors.lastname: Woessner
authors.affiliation: Health - Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft m.b.H., Graz, Austria.|Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Thomas Rudolf
authors.initials: TR
authors.lastname: Pieber
authors.affiliation: Beijing Novartis Pharma Co. Ltd., Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Novartis Institutes for BioMedical Research, Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Loesche
authors.affiliation: Health - Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft m.b.H., Graz, Austria.|Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Frank
authors.initials: F
authors.lastname: Sinner
authors.affiliation: Novartis Institutes for BioMedical Research, Basel, Switzerland.
authors.forename: Gerard
authors.initials: G
authors.lastname: Bruin
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology / Q000493:pharmacokinetics*; D061067:Antibodies, Monoclonal, Humanized; D001826:Body Fluids / Q000378:metabolism*; D001835:Body Weight; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007279:Injections, Subcutaneous; D020381:Interleukin-17 / Q000276:immunology; D010477:Perfusion; D011565:Psoriasis / Q000378:metabolism*; D013997:Time Factors
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C508717:IL17A protein, human; D020381:Interleukin-17; C555450:secukinumab
keywords: dermal open flow microperfusion; monoclonal antibody; pharmacokinetics; psoriasis; secukinumab