title: Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy.
abstract: The high prevalence of Japanese cedar pollinosis in Japan is associated with a negative impact on the quality of life of patients, as well as significant loss of productivity among the workforce in early spring, thus representing a serious social problem. Furthermore, the prevalence is increasing, and has risen by more than 10% in this decade. Cry j 1 and Cry j 2 were identified as the major allergens in Japanese cedar pollen (JCP), and in 2004, the existence of other major and minor allergens were revealed by a combination of two-dimensional electrophoresis and immunoblotting analysis. Allergenome analysis identified a chitinase, a lipid transfer protein, a serine protease, and an aspartic protease as novel IgE-reactive allergens in patients with JCP allergy. Thaumatin-like protein (Cry j 3) was shown to be homologous to Jun a 3, a major allergen from mountain cedar pollen. Isoflavone reductase-like protein was also characterized in a study of a JCP cDNA library. The characterization of component allergens is required to clarify the sensitizer or cross-reactive elicitor allergens for component-resolved diagnosis (CRD). Increasing evidence from numerous clinical trials indicates that CRD can be used to design effective allergen-specific immunotherapy. In this review, we summarize the eight characterized JCP allergens and discuss the impact of CRD and characterization of novel allergens on allergen-specific immunotherapy.
authors.affiliation: RIKEN-TORII Joint Research Team, RIKEN Center for Integrative Medical Sciences, RIKEN (The Institute of Physical and Chemical Research), Kanagawa, Japan. Electronic address: takashi.fujimura@riken.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimura
authors.affiliation: Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan. Electronic address: skawa@hiroshima-u.ac.jp.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawamoto
mesh_terms: D000485:Allergens / Q000276:immunology*; D052179:Antigens, Plant / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D032485:Cryptomeria / Q000009:adverse effects*; D003888:Desensitization, Immunologic; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology; D007564:Japan; D011058:Pollen / Q000276:immunology*; D057285:Precision Medicine; D015995:Prevalence; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D007073:Immunoglobulin E
keywords: Allergen-specific immunotherapy; Component-resolved diagnosis; Japanese cedar pollinosis; Oral allergy syndrome; Seasonal rhinitis