title: [Progress in research on imprinted gene associated with male infertility].
abstract: The connection between male infertility and abnormal methylation of imprinted genes has attracted much attention. Some imprinted genes, e.g., H19, MEG3, MEST and SNRPN, are known to be related with male infertility. Abnormal imprinted information may influence sperm concentration, motility and morphology, but the mechanism is still unclear. Sperm genomic imprinting reconstruction and erase respectively occur at the time of spermatogenesis and before embryo transfer. Many studies have shown that the probability of imprinting disorder syndrome of offspring born through assisted reproductive technology (ART) was significantly higher, leading to the worry about the safety of ART and speculation that the operation and in vitro environment may affect sperm imprinted information, which in turn may lead to imprinting diseases in the offspring. However, above connection still lacks convincing evidence. This paper has conducted a literature review of recent literature and explored the impact of abnormal methylation of imprinted genes on male fertility and the offspring.
authors.affiliation: Reproductive Medicine Center, First Hospital, Department of Medical Genetics, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China. Email: lrz410@126.com.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Wang
authors.forename: Ruixue
authors.initials: R
authors.lastname: Wang
authors.forename: Ruizhi
authors.initials: R
authors.lastname: Liu
mesh_terms: D018392:Genomic Imprinting; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D011506:Proteins / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics; D027724:Reproductive Techniques, Assisted
chemical_list: C094335:H19 long non-coding RNA; C498907:MEG3 non-coding RNA, human; D011506:Proteins; D062085:RNA, Long Noncoding; C103637:mesoderm specific transcript protein