title: Hybrid stent device of flow-diverting effect and stent-assisted coil embolization formed by fractal structure.
abstract: This paper presents a novel hybrid medical stent device. This hybrid stent device formed by fractal mesh structures provides a flow-diverting effect and stent-assisted coil embolization. Flow-diverter stents decrease blood flow into an aneurysm to prevent its rupture. In general, the mesh size of a flow-diverter stent needs to be small enough to prevent blood flow into the aneurysm. Conventional flow-diverter stents are not available for stent-assisted coil embolization, which is an effective method for aneurysm occlusion, because the mesh size is too small to insert a micro-catheter for coil embolization. The proposed hybrid stent device is capable of stent-assisted coil embolization while simultaneously providing a flow-diverting effect. The fractal stent device is composed of mesh structures with fine and rough mesh areas. The rough mesh area can be used to insert a micro-catheter for stent-assisted coil embolization. Flow-diverting effects of two fractal stent designs were composed to three commercially available stent designs. Flow-diverting effects were analyzed using computational fluid dynamics (CFD) analysis and particle image velocimetry (PIV) experiment. Based on the CFD and PIV results, the fractal stent devices reduce the flow velocity inside an aneurism just as much as the commercially available flow-diverting stents while allowing stent-assisted coil embolization.
authors.affiliation: Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Aichi, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kojima
authors.affiliation: Department of Neurosurgery of Fujita, Health University, Nagoya, Aichi, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Irie
authors.affiliation: Department of Mechanical Science and Engineering, Nagoya University, Nagoya, Aichi, Japan.
authors.forename: Kouhei
authors.initials: K
authors.lastname: Masunaga
authors.affiliation: Department of Mechanical Science and Engineering, Nagoya University, Nagoya, Aichi, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sakai
authors.affiliation: Center for Micro-Nano Mechatronics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8603, Japan. nakajima@mein.nagoya-u.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Aichi, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: Faculty of Science and Engineering, Meijo University, Siogamaguchi 1-501, Tenpaku-ku, Nagoya, Aichi, 468-8502, Japan. tofukuda@meijo-u.ac.jp.|Institute for Advanced Research, Nagoya University, Nagoya, Aichi, Japan. tofukuda@meijo-u.ac.jp.|Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China. tofukuda@meijo-u.ac.jp.
authors.forename: Toshio
authors.initials: T
authors.lastname: Fukuda
authors.affiliation: Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Aichi, Japan.
authors.forename: Fumihito
authors.initials: F
authors.lastname: Arai
authors.affiliation: Ichinomiyanishi Hospital, Nagoya, Aichi, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Negoro
mesh_terms: D000783:Aneurysm / Q000628:therapy; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D017709:Fractals; D018056:Hemorheology; D019047:Phantoms, Imaging; D011474:Prosthesis Design; D011673:Pulsatile Flow; D015607:Stents
keywords: Aneurysm; Computational fluid dynamics; Flow-diverting effect; Fractal structure; Particle image velocimetry; Stent device