title: Diagnostic Dilemma in Sequential Branch Retinal Vein and Artery Occlusion.
abstract: OBJECTIVE
  To report on an unusual case of a branch retinal vein occlusion followed by occlusion of the respective branch retinal artery of the same eye 7 years later, in a young, otherwise healthy man with marginal elevation of antiphospholipid antibodies.
  
  
  METHODS
  On first presentation, a 30-year-old male patient was diagnosed as having a branch retinal vein occlusion with the sole risk factor of slightly increased diastolic pressure. On second presentation, 7 years later, a transient occlusion of the respective branch retinal artery was diagnosed on the same patient. Extensive ophthalmologic and general medical evaluations were performed including cardiovascular, coagulation, and immunology testing. Coagulopathy screening revealed slightly elevated titers of anticardiolipin IgM and anti-beta 2 glycoprotein-I IgM antibodies, and aspirin prophylaxis was initiated.
  
  
  CONCLUSIONS
  Retinal vascular occlusions are typically associated with well-defined, classical risk factors in older people. In younger, otherwise healthy patients, further autoimmune hypercoagulable disorders are often causal. Our case suggests the contribution of slightly elevated antiphospholipid IgM antibodies, although this remains to be proven.
authors.affiliation: *MD Department of Ophthalmology, University Hospitals and School of Medicine, Geneva, Switzerland (A Consigli, DR, GS, A Chronopoulos); and Department of Immunology and Allergy, University Hospitals and School of Medicine, Geneva, Switzerland (CC, GT).
authors.forename: Andrea
authors.initials: A
authors.lastname: Consigli
authors.forename: Daniel
authors.initials: D
authors.lastname: Roquelaure
authors.forename: Georges
authors.initials: G
authors.lastname: Souteyrand
authors.forename: Carlo
authors.initials: C
authors.lastname: Chizzolini
authors.forename: Gabriele
authors.initials: G
authors.lastname: Thumann
authors.forename: Argyrios
authors.initials: A
authors.lastname: Chronopoulos
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D001241:Aspirin / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005451:Fluorescein Angiography; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D015356:Retinal Artery Occlusion / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D012170:Retinal Vein Occlusion / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D012307:Risk Factors; D014792:Visual Acuity / Q000502:physiology; D053482:beta 2-Glycoprotein I / Q000276:immunology
chemical_list: D017153:Antibodies, Anticardiolipin; D005343:Fibrinolytic Agents; D007075:Immunoglobulin M; D016682:Lupus Coagulation Inhibitor; D053482:beta 2-Glycoprotein I; D001241:Aspirin