title: EBV-associated Burkitt lymphoma in Taiwan is not age-related.
abstract: This study retrospectively investigated 54 cases of sporadic Burkitt lymphoma in Taiwan with histopathology review, immunohistochemistry, Epstein-Barr virus (EBV) in situ hybridization (EBER) and fluorescence in situ hybridization (FISH). The great majority revealed typical immunophenotype and 89% (47/53) cases expressed myc protein. EBER was positive in 20% (11/54) of cases, more frequently with nodal presentation, but not significantly associated with age (pediatric vs. adult), abdominal vs. extra-abdominal presentation or overall survival (OS). MYC and IGH were rearranged in 94% (46/49) and 85% (41/48) of cases, respectively. The concordance rate between myc expression and MYC translocation was 83% (40/48). By univariate analysis, OS was statistically associated with age, with or without chemotherapy, central nervous system (CNS) involvement, CNS prophylaxis and leukemic transformation, but not gender, nodal vs. extranodal involvement, stage, immunohistochemistry, EBER, myc expression, MYC translocation or radiotherapy. By multivariate analysis, CNS involvement at presentation and administration of chemotherapy were statistically associated with OS.
authors.affiliation: a Department of Pathology , Shuang Ho Hospital, Taipei Medical University , New Taipei City , Taiwan .
authors.forename: Bo-Jung
authors.initials: BJ
authors.lastname: Chen
authors.affiliation: b Department of Pathology , Chi-Mei Medical Center , Tainan , Taiwan .|c Department of Nursing , National Tainan Institute of Nursing , Tainan , Taiwan .
authors.forename: Sheng-Tsung
authors.initials: ST
authors.lastname: Chang
authors.affiliation: d Department of Healthcare Administration and Medical Informatics , Kaohsiung Medical University , Kaohsiung , Taiwan .
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Weng
authors.affiliation: e Department of Pathology , Kaohsiung Chang Gung Memorial Hospital-Kaohsiung Medical Center , Kaohsiung , Taiwan .|f College of Medicine , Kaohsiung and Chang Gung University , Kaohsiung , Taiwan .
authors.forename: Wan-Ting
authors.initials: WT
authors.lastname: Huang
authors.affiliation: g Department of Pathology , St. Martin De Porres Hospital , Chiayi , Taiwan .|h School of Medicine , Fu-Jen Catholic University , New Taipei City , Taiwan .
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Chu
authors.affiliation: i Department of Pathology and Laboratory Medicine , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan .|j National Defense Medical Center , Taipei , Taiwan .
authors.forename: Pin-Pen
authors.initials: PP
authors.lastname: Hsieh
authors.affiliation: k Department of Pathology , Sin-Lau Christian Hospital , Tainan , Taiwan .
authors.forename: Yun-Chih
authors.initials: YC
authors.lastname: Jung
authors.affiliation: b Department of Pathology , Chi-Mei Medical Center , Tainan , Taiwan .
authors.forename: Chun-Chi
authors.initials: CC
authors.lastname: Kuo
authors.affiliation: l Department of Pathology , National Cheng Kung University Hospital , Tainan , Taiwan , and.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Chuang
authors.affiliation: b Department of Pathology , Chi-Mei Medical Center , Tainan , Taiwan .|m Department of Pathology, College of Medicine , Taipei Medical University and National Taiwan University , Taipei , Taiwan.
authors.forename: Shih-Sung
authors.initials: SS
authors.lastname: Chuang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology; D016896:Treatment Outcome; D055815:Young Adult
keywords: Burkitt lymphoma; EBV; MYC; Taiwan; fluorescence in situ hybridization