title: VBN-based nomograms provide critical voiding parameters which can be used for invasive or non-invasive flow interpretation of women at risk of obstruction over time.
abstract: To design a simple office-based method to evaluate characteristic parameters from free uroflowmetries (FF) or pressure flow studies (PFs). This method can be applied by any physician to any recording, for instance in the follow-up of women at risk of developing outflow obstruction over time after surgical interventions.
  
  
  
  Using pressure-flow studies (PFs), a reliable evaluation of urethral obstruction (U) and detrusor contractility (k) parameters could be obtained from the maximum flow rate and detrusor pressure at maximum flow rate. Nomograms for these parameters were derived from theoretical computations using the VBN model. Then, to allow an evaluation of the real urethral obstruction, a protocol was designed incorporating FF data in the follow-up of women suspected of urethral obstruction.
  
  
  
  Two nomograms were obtained: (1) A urethral obstruction nomogram allowing to define a Woman Obstruction Index (WOI = pdet.Qmax- 0.5*Qmax) which has the same structure than the A-G number in men. (2) A detrusor contractility nomogram which was generalized to all initial bladder volumes. The curves were fitted by algebraic equations easily programmable on any handheld device.
  
  
  
  Using a mathematical model of micturition and data extracted from PFs, two nomograms on urethral obstruction and detrusor contractility were designed. This tool offers a rapid and practical method for the clinician to follow women at risk of obstruction over time. Its applications will be the purpose of further studies. Neurourol. Urodynam. 36:37-42, 2017. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Université Pierre et Marie CURIE (Paris 06) Paris and Hôpital Rothschild, Paris, France.
authors.forename: Françoise A
authors.initials: FA
authors.lastname: Valentini
authors.affiliation: Université Pierre et Marie CURIE (Paris 06) Paris and Hôpital Rothschild, Paris, France.
authors.forename: Pierre P
authors.initials: PP
authors.lastname: Nelson
authors.affiliation: University of Texas Southwestern, Dallas, Texas.
authors.forename: Philippe E
authors.initials: PE
authors.lastname: Zimmern
mesh_terms: D000465:Algorithms; D005260:Female; D006801:Humans; D009119:Muscle Contraction; D049451:Nomograms; D011312:Pressure; D018570:Risk Assessment; D014521:Urethra / Q000503:physiopathology; D014524:Urethral Obstruction / Q000175:diagnosis* / Q000503:physiopathology; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000503:physiopathology; D001748:Urinary Bladder Neck Obstruction / Q000175:diagnosis* / Q000503:physiopathology; D014554:Urination; D014563:Urodynamics
keywords: VBN modelling; bladder outlet obstruction; detrusor contractility; nomograms; urodynamics