title: Regulation of lipid disorders by ethanol extracts from Zingiber zerumbet in high-fat diet-induced rats.
abstract: The aim of this study was to investigate the antihyperlipidaemic effects of the ethanol extract of Zingiber zerumbet (L) Smith (EEZZ). After being fed a high-fat diet (HFD) for 2weeks, rats were dosed orally with EEZZ (100, 200 or 300mg/kg) or fenofibrate (100mg/kg) once daily for 8weeks. EEZZ (300mg/kg/day) produced effects similar to fenofibrate in reducing body weight gain, visceral fat-pad weights and plasma lipid levels. EEZZ caused reductions in hepatic triglyceride and cholesterol content, and lowered hepatic lipid droplet accumulation and the size of epididymal adipocytes. HFD-induced reductions in the hepatic proteins of peroxisome proliferator-activated receptor (PPAR) α, acyl-CoA oxidase (ACO) and cytochrome P450 isoform 4A1 (CYP4A1) were reversed by EEZZ. These results suggest that EEZZ reduced the accumulation of visceral fat and improved hyperlipidaemia in HFD-fed rats by increasing fatty acid oxidation, an effect which is likely to be mediated via up-regulation of hepatic PPARα.
authors.affiliation: School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan, ROC. Electronic address: 7419417@yahoo.com.tw.
authors.forename: Chia Ju
authors.initials: CJ
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Pao Chien Hospital, Pingtung City, Pingtung County, Taiwan, ROC. Electronic address: johnson0425.tzeng@gmail.com.
authors.forename: Thing-Fong
authors.initials: TF
authors.lastname: Tzeng
authors.affiliation: Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Township, Pingtung County, Taiwan, ROC. Electronic address: ssliou@mail.tajen.edu.tw.
authors.forename: Shorong-Shii
authors.initials: SS
authors.lastname: Liou
authors.affiliation: School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan, ROC. Electronic address: 2770727@yahoo.com.tw.
authors.forename: Yuan-Shiun
authors.initials: YS
authors.lastname: Chang
authors.affiliation: Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Township, Pingtung County, Taiwan, ROC. Electronic address: iml@mail.tajen.edu.tw.
authors.forename: I-Min
authors.initials: IM
authors.lastname: Liu
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D000431:Ethanol / Q000378:metabolism*; D020939:Zingiber officinale; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry*; D010940:Plant Proteins / Q000737:chemistry*; D051381:Rats
chemical_list: D000960:Hypolipidemic Agents; D010936:Plant Extracts; D010940:Plant Proteins; D000431:Ethanol
keywords: Acyl-CoA oxidase; Cytochrome P450 isoform 4A1; High-fat diet; Peroxisome proliferator activated receptor α; Zingiber zerumbet