title: Raltegravir Pharmacokinetics in Patients on Asunaprevir-Daclatasvir.
abstract: Raltegravir pharmacokinetics was studied in 20 patients included in the ANRS HC30 QUADRIH Study before and after addition of anti-hepatitis C virus (anti-HCV) quadritherapy, including pegylated-interferon-ribavirin and asunaprevir plus daclatasvir. Raltegravir pharmacokinetic parameters remained unchanged whether administered on or off anti-HCV therapy. In addition, concentrations of raltegravir, asunaprevir, and daclatasvir were not affected by liver cirrhosis. These data suggest that in human immunodeficiency virus (HIV)-HCV-coinfected patients, whether cirrhotic or not, asunaprevir and daclatasvir could be administered safely with raltegravir.
authors.affiliation: AP-HP, Hôpital Bicêtre, Pharmacie Clinique, Le Kremlin Bicêtre, France Université Paris Sud, INSERM UMR 1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, France aurelie.barrail-tran@bct.aphp.fr.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Barrail-Tran
authors.affiliation: INSERM SC10-US019, Villejuif, France.
authors.forename: Corine
authors.initials: C
authors.lastname: Vincent
authors.affiliation: AP-HP, Hôpital Bicêtre, Pharmacie Clinique, Le Kremlin Bicêtre, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Furlan
authors.affiliation: Centre Hospitalier Intercommunal, Service d'Hépato-Gastro-Entérologie, Créteil, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rosa
authors.affiliation: CHU de Nice, Hôpital de l'Archet, Service de Médecine Interne, Nice, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Rosenthal
authors.affiliation: CH de Tourcoing Hôpital Gustave Dron, SRU Maladies Infectieuses et du Voyageur, Tourcoing, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Cheret
authors.affiliation: Hôpital Saint Louis Université Paris Diderot, Service des Maladies Infectieuses et Tropicales, Paris, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Molina
authors.affiliation: AP-HP, Hôpital Bicêtre, Pharmacie Clinique, Le Kremlin Bicêtre, France Université Paris Sud, INSERM UMR 1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Taburet
authors.affiliation: Infectious Diseases Department, Centre Hospitalo-Universitaire, and UMR 1347, Université de Bourgogne, Dijon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Piroth
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002219:Carbamates; D060085:Coinfection; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D016174:Hepacivirus / Q000187:drug effects / Q000502:physiology; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000627:therapeutic use; D007546:Isoquinolines / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011759:Pyrrolidines; D000068898:Raltegravir Potassium / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012254:Ribavirin / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use*; D014633:Valine / Q000031:analogs & derivatives
chemical_list: D000998:Antiviral Agents; D002219:Carbamates; D007093:Imidazoles; D016898:Interferon-alpha; D007546:Isoquinolines; D011759:Pyrrolidines; D011994:Recombinant Proteins; D013449:Sulfonamides; D011092:Polyethylene Glycols; D000068898:Raltegravir Potassium; D012254:Ribavirin; D014633:Valine; C549273:daclatasvir; C100416:peginterferon alfa-2a; C571889:asunaprevir