title: One of these is not like the others.
abstract: A Mycobacterium tuberculosis metA mutant that is auxotrophic for methionine is unlike other auxotrophic mutants of this important species as methionine starvation results in rapid death instead of cessation of growth. Evidence suggests that this phenotype results from starvation affecting essential pathways that utilize S-adenosylmethionine in addition to methionine.
authors.affiliation: Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA. Electronic address: martin_pavelka@urmc.rochester.edu.
authors.forename: Martin S
authors.initials: MS
authors.lastname: Pavelka
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D006801:Humans; D008715:Methionine / Q000378:metabolism*; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000378:metabolism*; D012436:S-Adenosylmethionine / Q000378:metabolism*; D014376:Tuberculosis / Q000382:microbiology
chemical_list: D000596:Amino Acids; D012436:S-Adenosylmethionine; D008715:Methionine
keywords: S-adenosylmethionine; auxotroph; methionine; tuberculosis