title: Cyclin D1 and Ki-67 expression correlates to tumor staging in tongue squamous cell carcinoma.
abstract: BACKGROUND
  The immunohistochemical expression of Cyclin D1 and Ki-67 were analyzed in tongue squamous cell carcinomas (SCC), relating them to the clinical and morphological exhibition of these tumors.
  
  
  METHODS
  Twenty-nine patients fulfilled the inclusion criteria; clinical data included gender, age, ethnicity and use of licit drugs such as alcohol and tobacco. The TNM staging and histopathological differentiation grading was assessed for each case. In addition, T1 patients were gathered with T2 patients; and T3 patients were gathered with T4 patients to assemble two distinct groups: (T1/T2) and (T3/T4).
  
  
  RESULTS
  The mean follow-up time was 24 months and 30% of the patients died as a consequence of the disease, while 23.3% lived with the disease and 46.7% lived lesion-free. T1 and T2 tumors showed statistically lesser Ki-67 and Cyclin D1 staining when compared to T3 and T4 tumors.
  
  
  CONCLUSIONS
  Ki-67 and Cyclin D1 pose as auxiliary tools when determining the progression of tongue SCC at the time of diagnosis.
authors.affiliation: Departamento de Clínica e Cirurgia, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 Centro, Alfenas, MG, Brasil ZIP CODE: 37130-000, eduardopereiraguimaraes@gmail.com.
authors.forename: Eduardo-Pereira
authors.initials: EP
authors.lastname: Guimarães
authors.forename: Marina-Lara
authors.initials: ML
authors.lastname: de Carli
authors.forename: Felipe-Fornias
authors.initials: FF
authors.lastname: Sperandio
authors.forename: João-Adolfo-Costa
authors.initials: JA
authors.lastname: Hanemann
authors.forename: Alessandro-Antônio-Costa
authors.initials: AA
authors.lastname: Pereira
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D019938:Cyclin D1 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: C530104:CCND1 protein, human; D019394:Ki-67 Antigen; D019938:Cyclin D1