title: Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging.
abstract: The combination of therapy and diagnosis has been emerging as a promising strategy for cancer treatment. To realize chemotherapy, photothermal therapy, and magnetic resonance imaging (MRI) in one system, we have synthesized a new magnetic nanoparticle (Gd@SiO2-DOX/ICG-PDC) integrating doxorubicin (DOX), indocyanine green (ICG), and gadolinium(III)-chelated silica nanospheres (Gd@SiO2) with a poly(diallyldimethylammonium chloride) (PDC) coating. PDC coating serves as a polymer layer to protect from quick release of drugs from the nanocarriers and increase cellular uptake. The DOX release from Gd@SiO2-DOX/ICG-PDC depends on pH and temperature. The process will be accelerated in the acidic condition than in a neutral pH 7.4. Meanwhile, upon laser irradiation, the photothermal effects promote DOX release and improve the therapeutic efficacy compared to either DOX-loaded Gd@SiO2 or ICG-loaded Gd@SiO2. Moreover, MRI results show that the Gd@SiO2-PDC nanoparticles are safe T1-type MRI contrast agents for imaging. The Gd@SiO2-PDC nanoparticles loaded with DOX and ICG can thus act as a promising theranostic platform for multimodal cancer treatment.
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100190, P. R. China.|Sino-Danish Center for Education and Research , Beijing 100190, P. R. China.
authors.forename: Mingjing
authors.initials: M
authors.lastname: Cao
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Pengyang
authors.initials: P
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100190, P. R. China.|Laboratory of Fiber Materials and Modern Textile, The Growing Base for State Key Laboratory, Qingdao University , Qingdao 266003, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Kou
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Laboratory of Fiber Materials and Modern Textile, The Growing Base for State Key Laboratory, Qingdao University , Qingdao 266003, P. R. China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Li
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Jiayang
authors.initials: J
authors.lastname: Li
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016923:Cell Death / Q000187:drug effects; D002614:Chelating Agents / Q000737:chemistry*; D004705:Endocytosis / Q000187:drug effects; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D007477:Ions; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy*; D010789:Phototherapy; D012822:Silicon Dioxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D056928:X-Ray Absorption Spectroscopy
chemical_list: D000970:Antineoplastic Agents; D002614:Chelating Agents; D007477:Ions; D012822:Silicon Dioxide; D005682:Gadolinium
keywords: chemotherapy; drug delivery; gadolinium(III)-chelated silica nanospheres; magnetic resonance imaging; mesoporous silica nanoparticles; multimodal therapy; photothermal therapy