title: Intergenomic interactions between mitochondrial and Y-linked genes shape male mating patterns and fertility in Drosophila melanogaster.
abstract: Under maternal inheritance, mitochondrial genomes are prone to accumulate mutations that exhibit male-biased effects. Such mutations should, however, place selection on the nuclear genome for modifier adaptations that mitigate mitochondrial-incurred male harm. One gene region that might harbor such modifiers is the Y-chromosome, given the abundance of Y-linked variation for male fertility, and because Y-linked modifiers would not exert antagonistic effects in females because they would be found only in males. Recent studies in Drosophila revealed a set of nuclear genes whose expression is sensitive to allelic variation among mtDNA- and Y-haplotypes, suggesting these genes might be entwined in evolutionary conflict between mtDNA and Y. Here, we test whether genetic variation across mtDNA and Y haplotypes, sourced from three disjunct populations, interacts to affect male mating patterns and fertility across 10 days of early life in D. melanogaster. We also investigate whether coevolved mito-Y combinations outperform their evolutionarily novel counterparts, as predicted if the interacting Y-linked variance is comprised of modifier adaptations. Although we found no evidence that coevolved mito-Y combinations outperformed their novel counterparts, interactions between mtDNA and Y-chromosomes affected male mating patterns. These interactions were dependent on male age; thus male reproductive success was shaped by G × G × E interactions.
authors.affiliation: School of Biological Sciences, Monash University, Clayton, 3800, Victoria, Australia. winston.yee@monash.edu.
authors.forename: Winston K W
authors.initials: WK
authors.lastname: Yee
authors.affiliation: School of Biological Sciences, Monash University, Clayton, 3800, Victoria, Australia.|Department of Zoology/Ecology, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Rogell
authors.affiliation: Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, 02115.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Lemos
authors.affiliation: School of Biological Sciences, Monash University, Clayton, 3800, Victoria, Australia.
authors.forename: Damian K
authors.initials: DK
authors.lastname: Dowling
mesh_terms: D000483:Alleles; D000818:Animals; D005075:Biological Evolution; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005260:Female; D005298:Fertility / Q000235:genetics*; D017344:Genes, Insect; D050259:Genes, Mitochondrial; D050173:Genes, Y-Linked; D014644:Genetic Variation; D006239:Haplotypes; D008297:Male; D012098:Reproduction / Q000235:genetics
keywords: Adaptation; genomic conflict; male fertility; mitonuclear; mtDNA; sexual conflict