title: Quantitative Assessment of Parkinsonian Tremor Based on an Inertial Measurement Unit.
abstract: Quantitative assessment of parkinsonian tremor based on inertial sensors can provide reliable feedback on the effect of medication. In this regard, the features of parkinsonian tremor and its unique properties such as motor fluctuations and dyskinesia are taken into account. Least-square-estimation models are used to assess the severities of rest, postural, and action tremors. In addition, a time-frequency signal analysis algorithm for tremor state detection was also included in the tremor assessment method. This inertial sensor-based method was verified through comparison with an electromagnetic motion tracking system. Seven Parkinson's disease (PD) patients were tested using this tremor assessment system. The measured tremor amplitudes correlated well with the judgments of a neurologist (r = 0.98). The systematic analysis of sensor-based tremor quantification and the corresponding experiments could be of great help in monitoring the severity of parkinsonian tremor.
authors.affiliation: Quanzhou Institute of Equipment Manufacturing, Haixi Institutes, Chinese Academy of Sciences, Bolan Av., Jinjiang 362200, China. dhd@fjirsm.ac.cn.|Institute of Micro Technology and Medical Device Technology, Technische Universitaet Muenchen, 85748 Garching, Germany. dhd@fjirsm.ac.cn.
authors.forename: Houde
authors.initials: H
authors.lastname: Dai
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China. zpy19802000@163.com.
authors.forename: Pengyue
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Institute of Micro Technology and Medical Device Technology, Technische Universitaet Muenchen, 85748 Garching, Germany. tim.lueth@tum.de.
authors.forename: Tim C
authors.initials: TC
authors.lastname: Lueth
mesh_terms: D061725:Accelerometry / Q000295:instrumentation; D000465:Algorithms; D015374:Biosensing Techniques / Q000295:instrumentation*; D003943:Diagnostic Techniques, Neurological / Q000295:instrumentation; D055590:Electromagnetic Phenomena; D006801:Humans; D063731:Mobile Applications; D018670:Monitoring, Ambulatory / Q000295:instrumentation; D009038:Motion; D010300:Parkinson Disease / Q000175:diagnosis*; D012720:Severity of Illness Index; D014202:Tremor / Q000175:diagnosis*
keywords: Inertial measurement unit; Parkinson’s disease; technical validation; tremor quantification; wearable system