title: Effectiveness of long-acting risperidone in a patient with comorbid intellectual disability, catatonic schizophrenia, and oneiroid syndrome.
abstract: A patient with comorbid intellectual disability, catatonic schizophrenia, and recurrent oneiroid state of consciousness improved on long-acting risperidone and remains well at the three-year follow-up. We report a case treated with 50 mg long-acting risperidone administered every 14 days, who has been followed-up for three years. We studied his regional cerebral blood flow through technetium-99 m hexamethylpropyleneamine oxime single-photon emission computed tomography after two years of treatment. Symptoms of catatonic schizophrenia improved after two months of treatment, followed suit by oneiroid syndrome remission. Two years later, his brain perfusion was normal. No side effect has occurred since the patient was started on long-acting risperidone. Long-acting risperidone proved to be safe and effective in treating symptoms of catatonia and oneiroid syndrome.
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy Department of Neuropsychiatry, Suore Hospitaliere of the Sacred Heart of Jesus, Viterbo, Italy seratadaniele@gmail.com.
authors.forename: Daniele
authors.initials: D
authors.lastname: Serata
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy Department of Neuropsychiatry, Suore Hospitaliere of the Sacred Heart of Jesus, Viterbo, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Rapinesi
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy.
authors.forename: Georgios Demetrios
authors.initials: GD
authors.lastname: Kotzalidis
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Alessi
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy.
authors.forename: Delfina
authors.initials: D
authors.lastname: Janiri
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy.
authors.forename: Anna Claudia
authors.initials: AC
authors.lastname: Massolo
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy Department of Neuropsychiatry, Suore Hospitaliere of the Sacred Heart of Jesus, Viterbo, Italy.
authors.forename: Vittoria Rachele
authors.initials: VR
authors.lastname: Ferri
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Criscuolo
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy.
authors.forename: Gemma
authors.initials: G
authors.lastname: Callovini
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy.
authors.forename: Gloria
authors.initials: G
authors.lastname: Angeletti
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy School of Medicine and Psychology, Unit of Psychiatry, Sant'Andrea Hospital, Rome, Italy Department of Neuropsychiatry, Suore Hospitaliere of the Sacred Heart of Jesus, Viterbo, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Girardi
authors.affiliation: NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University, Rome, Italy Department of Psychiatric Rehabilitation, P. Alberto Mileno Onlus Foundation, Vasto (CH), Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Del Casale
mesh_terms: D000328:Adult; D000551:Ambroxol; D014150:Antipsychotic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects; D004325:Dreams / Q000523:psychology; D005500:Follow-Up Studies; D006801:Humans; D008607:Intellectual Disability / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D011877:Radionuclide Imaging; D018967:Risperidone / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012560:Schizophrenia, Catatonic / Q000150:complications* / Q000188:drug therapy*; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D000551:Ambroxol; D018967:Risperidone
keywords: Schizophrenia; catatonia; intellectual disability; long-acting; oneiroid state; risperidone; single-photon emission computed tomography (SPECT)