title: Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study.
abstract: The beneficial effects of probiotics are now widely reported, although there are only a few studies on their anti-aging effects. We have found that Lactobacillus plantarum HY7714 (HY7714) improves skin hydration and has anti-photoaging effects, and in the present study, we have further evaluated the anti-aging effect of HY7714 via a randomized, double blind, placebo-controlled clinical trial. The trial included 110 volunteers aged 41 and 59 years who have dry skin and wrinkles. Participants took 1 × 10(10) CFU/day of HY7714 (probiotic group) or a placebo (placebo group) for 12 weeks. Skin hydration, wrinkles, skin gloss, and skin elasticity were measured every 4 weeks during the study period. There were significant increases in the skin water content in the face (p < 0.01) and hands (p < 0.05) at week 12 in the probiotic group. Transepidermal water loss decreased significantly in both groups at weeks 4, 8, and 12 (p < 0.001 compared with baseline), and was suppressed to a greater extent in the face and forearm in the probiotic group at week 12. Volunteers in the probiotic group had a significant reduction in wrinkle depth at week 12, and skin gloss was also significantly improved by week 12. Finally, skin elasticity in the probiotic group improved by 13.17% (p < 0.05 vs. controls) after 4 weeks and by 21.73% (p < 0.01 vs. controls) after 12 weeks. These findings are preliminary confirmation of the anti-aging benefit to the skin of L. plantarum HY7714 as a nutricosmetic agent.
authors.affiliation: Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea.
authors.forename: Dong Eun
authors.initials: DE
authors.lastname: Lee
authors.affiliation: Graduate School of International Agricultural Technology, Institute of Green Bio Science & Technology, Seoul National University, Pyeongchang 232-916, Republic of Korea.
authors.forename: Chul-Sung
authors.initials: CS
authors.lastname: Huh
authors.affiliation: Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea.
authors.forename: Jehyeon
authors.initials: J
authors.lastname: Ra
authors.affiliation: Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea.
authors.forename: Il-Dong
authors.initials: ID
authors.lastname: Choi
authors.affiliation: Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea.
authors.forename: Ji-Woong
authors.initials: JW
authors.lastname: Jeong
authors.affiliation: Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea.
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Dermapro Skin Research Center, DERMAPRO Ltd., Seoul 137-843, Republic of Korea.
authors.forename: Ja Hyun
authors.initials: JH
authors.lastname: Ryu
authors.affiliation: Dermapro Skin Research Center, DERMAPRO Ltd., Seoul 137-843, Republic of Korea.
authors.forename: Young Kyoung
authors.initials: YK
authors.lastname: Seo
authors.affiliation: Dermapro Skin Research Center, DERMAPRO Ltd., Seoul 137-843, Republic of Korea.
authors.forename: Jae Sook
authors.initials: JS
authors.lastname: Koh
authors.affiliation: Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea.
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea.
authors.forename: Jae-Hun
authors.initials: JH
authors.lastname: Sim
authors.affiliation: Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea.
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Ahn
mesh_terms: D004311:Double-Blind Method; D005260:Female; D006801:Humans; D048191:Lactiplantibacillus plantarum / Q000502:physiology*; D008875:Middle Aged; D010919:Placebos / Q000008:administration & dosage; D019936:Probiotics / Q000008:administration & dosage*; D015595:Skin Aging; D012879:Skin Physiological Phenomena; D016896:Treatment Outcome
chemical_list: D010919:Placebos
keywords: Anti-wrinkle; Lactobacillus plantarum; Skin elasticity; Skin gloss; Skin hydration