title: Leukemia cutis with lymphoglandular bodies: a clue to acute lymphoblastic leukemia cutis.
abstract: Leukemia cutis describes cutaneous lesions produced by infiltrates of leukemic cells. It usually manifests contemporaneously with the initial diagnosis of systemic leukemia, but may also precede or follow systemic leukemia. Most cases are associated with acute myeloid leukemia. Adult B-cell lymphoblastic leukemia cutis is very rare. We report a 59-year-old woman with a history of B-cell acute lymphoblastic leukemia who relapsed with aleukemic lymphoblastic leukemia cutis. Lymphoglandular bodies were conspicuous on biopsy and may serve as a morphologic clue to lymphocytic differentiation while molecular and immunophenotypic studies are pending. The patient was successfully treated with local radiation therapy and oral ponatinib.
authors.affiliation: University of Kansas School of Medicine.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Obiozor
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Ganguly
authors.forename: Garth R
authors.initials: GR
authors.lastname: Fraga
mesh_terms: D064591:Allografts; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D036101:Cord Blood Stem Cell Transplantation; D000069439:Dasatinib / Q000008:administration & dosage; D020405:Dermis / Q000648:ultrastructure*; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors / Q000235:genetics; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D016130:Immunophenotyping; D017254:Leukemic Infiltration / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D010677:Philadelphia Chromosome; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy / Q000628:therapy; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011724:Pyridazines / Q000627:therapeutic use; D012008:Recurrence; D012074:Remission Induction; D012535:Scalp / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D009363:Neoplasm Proteins; D047428:Protein Kinase Inhibitors; D011724:Pyridazines; C545373:ponatinib; D016044:Fusion Proteins, bcr-abl; D000069439:Dasatinib