title: Metastasized pancreatic neuroendocrine tumor in a teenage girl: a case report.
abstract: BACKGROUND
  Metastasized pancreatic neuroendocrine tumors are extremely rare malignancies, especially in children. Therefore, therapeutic options are limited, and few standardized therapy regimens exist.
  
  
  METHODS
  We report a case of a 14-year-old white girl. In 2011 she was diagnosed with a metastasized, well-differentiated pancreatic neuroendocrine tumor with expression of synaptophysin and chromogranin A. We describe her clinical course with special attention to her individual therapeutic regimens while bringing together several disciplines of medicine.
  
  
  CONCLUSIONS
  In patients such as ours, surgical intervention may be the only therapy that will lead to long-term survival.
authors.affiliation: Department of Pediatric Surgery, University Hospital Heidelberg, INF 110, 69120, Heidelberg, Germany. tina.tremmel@med.uni-heidelberg.de.
authors.forename: Tina
authors.initials: T
authors.lastname: Tremmel
authors.affiliation: Department of Pediatric Surgery, University Hospital Basel, Spitalstrasse 33, 4056, Basel, Switzerland. stefan.holland-cunz@ukbb.ch.
authors.forename: Stefan
authors.initials: S
authors.lastname: Holland-Cunz
authors.affiliation: Department of Pediatric Surgery, University Hospital Heidelberg, INF 110, 69120, Heidelberg, Germany. patrick.guenther@med.uni-heidelberg.de.
authors.forename: Patrick
authors.initials: P
authors.lastname: Günther
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols; D053379:Chromogranin A / Q000378:metabolism*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D015282:Octreotide / Q000008:administration & dosage / Q000031:analogs & derivatives; D009942:Organometallic Compounds / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D016577:Pancreaticoduodenectomy; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D013163:Splenomegaly / Q000209:etiology; D016708:Synaptophysin / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D053379:Chromogranin A; C499142:Ga(III)-DOTATOC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D016708:Synaptophysin; D015282:Octreotide