title: Serum leptin concentration in women of reproductive age with euthyroid autoimmune thyroiditis.
abstract: BACKGROUND
  Autoimmune thyroid disease (AITD) with elevated anti-thyroid peroxidase antibody (aTPO) levels appears in 12-25% of all women, apart from thyroid dysfunction. High titers of aTPO are more common in women with polycystic ovary syndrome and endometriosis. Elevated aTPO has been associated with infertility and poorer quality of life among euthyroid women, and may be related to other factors.
  
  
  OBJECTIVE
  The aim of the study was to measure differences in serum leptin concentration between AITD+ and AITD- patients. Setting, patients and main outcome measures: The sample was comprised of 74 women who were hospitalized in the Department of Gynecological Endocrinology, Medical University of Warsaw. Data collected included age, body mass index (BMI), and serum aTPO, serum thyroid stimulating hormone (TSH), serum fT4, serum follitropin (FSH), serum estradiol and serum leptin. AITD positive status was defined as serum aTPO greater than 5.6 mIU/ml.
  
  
  RESULTS
  Serum leptin concentrations were significantly higher in AITD+ patients compared to AITD- patients (17.13 ng/ml [SD 7.66] versus 12.78 ng/ml [SD 7.28]; p < 0.05). No differences by AITD status were found in age, BMI, TSH, FSH, estradiol and fT4.
  
  
  CONCLUSIONS
  Serum leptin concentrations were higher in patients with AITD than in patients without AITD.
authors.affiliation: a Department of Gynecological Endocrinology and.
authors.forename: Artur
authors.initials: A
authors.lastname: Drobniak
authors.affiliation: b Department of Health Care , Medical University of Warsaw , Warsaw , Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kanecki
authors.affiliation: a Department of Gynecological Endocrinology and.
authors.forename: Monika
authors.initials: M
authors.lastname: Grymowicz
authors.affiliation: a Department of Gynecological Endocrinology and.
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Radowicki
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D033862:Iron-Binding Proteins / Q000276:immunology*; D020738:Leptin / Q000097:blood*; D013967:Thyroiditis, Autoimmune / Q000097:blood*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D033862:Iron-Binding Proteins; D020738:Leptin; C056658:TPO protein, human; D007453:Iodide Peroxidase
keywords: Body mass index; leptin; thyroid