title: Histone Deacetylase: Therapeutic Targets in Retinal Degeneration.
abstract: Previous studies report that retinitis pigmentosa (RP) patients treated with the histone deacetylase inhibitor (HDACi) valproic acid (VPA) present with improved visual fields and delayed vision loss. However, other studies report poor efficacy and safety of HDACi in other cohorts of retinal degeneration patients. Furthermore, the molecular mechanisms by which HDACi can improve visual function is unknown, albeit HDACi can attenuate pro-apoptotic stimuli and induce expression of neuroprotective factors. Thus, further analysis of HDACi is warranted in pre-clinical models of retinal degeneration including zebrafish. Analysis of HDAC expression in developing zebrafish reveals diverse temporal expression patterns during development and maturation of visual function.
authors.affiliation: School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, 4, Dublin, Ireland. conor.daly@ucdconnect.ie.
authors.forename: Conor
authors.initials: C
authors.lastname: Daly
authors.affiliation: Department of Genetics, Yale University School of Medicine, 06520, New Haven, CT, USA. jun.yin@yale.edu.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, 4, Dublin, Ireland. brendan.kennedy@ucd.ie.
authors.forename: Breandán N
authors.initials: BN
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004195:Disease Models, Animal; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D051379:Mice; D010786:Photoreceptor Cells / Q000187:drug effects / Q000378:metabolism; D012162:Retinal Degeneration / Q000378:metabolism / Q000517:prevention & control*; D014635:Valproic Acid / Q000494:pharmacology; D014794:Visual Fields / Q000187:drug effects*; D015027:Zebrafish
chemical_list: D056572:Histone Deacetylase Inhibitors; D014635:Valproic Acid; D006655:Histone Deacetylases
keywords: Histone deacetylase; Histone deacetylase inhibtors; Retinal degen­eration; Retinitis pigmentosa; Zebrafish