title: Micelle-Based Adjuvants for Subunit Vaccine Delivery.
abstract: In the development of subunit vaccines with purified or recombinant antigens for cancer and infectious diseases, the design of improved and safe adjuvants able to efficiently target the antigen presenting cells, such as dendritic cells, represents a crucial challenge. Nanoparticle-based antigen delivery systems have been identified as an innovative strategy to improve the efficacy of subunit vaccines. Among them, self-assembled micellar nanoparticles from amphiphilic (macro)molecules have recently emerged as promising candidates. In this short review, we report on the recent research findings highlighting the versatility and potential of such systems in vaccine delivery.
authors.affiliation: Aix-Marseille Université, CNRS, CR UMR 7273, 13397 Marseille, France. thomas.trimaille@univ-amu.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Trimaille
authors.affiliation: Université Lyon 1, CNRS, LBTI UMR 5305, 69367 Lyon, France. bernard.verrier@ibcp.fr.
authors.forename: Bernard
authors.initials: B
authors.lastname: Verrier
keywords: amphiphilic copolymers; antigens; micelles; peptide amphiphiles