title: Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy.
abstract: Retinitis pigmentosa and cone/cone-rod dystrophy are inherited retinal diseases characterized by the progressive loss of rod and/or cone photoreceptors. To evaluate the status of rod/cone photoreceptors and visual function, visual acuity and visual field tests, electroretinogram, and optical coherence tomography are typically used. In addition to these examinations, fundus autofluorescence (FAF) has recently garnered attention. FAF visualizes the intrinsic fluorescent material in the retina, which is mainly lipofuscin contained within the retinal pigment epithelium. While conventional devices offer limited viewing angles in FAF, the recently developed Optos machine enables recording of wide-field FAF. With wide-field analysis, an association between abnormal FAF areas and visual function was demonstrated in retinitis pigmentosa and cone-rod dystrophy. In addition, the presence of "patchy" hypoautofluorescent areas was found to be correlated with symptom duration. Although physicians should be cautious when interpreting wide-field FAF results because the peripheral parts of the image are magnified significantly, this examination method provides previously unavailable information.
authors.affiliation: Departments of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara, Shogoin, Sakyo, 606-8507, Kyoto, Japan. aquio@kuhp.kyoto-u.ac.jp.
authors.forename: Akio
authors.initials: A
authors.lastname: Oishi
authors.affiliation: Departments of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara, Shogoin, Sakyo, 606-8507, Kyoto, Japan. mah0ham@kuhp.kyoto-u.ac.jp.
authors.forename: Maho
authors.initials: M
authors.lastname: Oishi
authors.affiliation: Departments of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara, Shogoin, Sakyo, 606-8507, Kyoto, Japan. kenboo@kuhp.kyoto-u.ac.jp.
authors.forename: Ken
authors.initials: K
authors.lastname: Ogino
authors.affiliation: Departments of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara, Shogoin, Sakyo, 606-8507, Kyoto, Japan. moro@kuhp.kyoto-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Morooka
authors.affiliation: Departments of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara, Shogoin, Sakyo, 606-8507, Kyoto, Japan. nagaeye@kuhp.kyoto-u.ac.jp.
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D005453:Fluorescence; D005654:Fundus Oculi; D006801:Humans; D008062:Lipofuscin / Q000737:chemistry* / Q000378:metabolism; D009887:Ophthalmoscopy; D055213:Retinal Pigment Epithelium / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000175:diagnosis* / Q000378:metabolism; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence
chemical_list: D008062:Lipofuscin
keywords: Cone rod dystrophy; Fundus autofluorescence; Retinitis pigmentosa; Stargardt disease; Ultra-widefield scanning laser ophthalmos­cope