title: Geranylgeranylacetone Suppresses N-Methyl-N-nitrosourea-Induced Photoreceptor Cell Loss in Mice.
abstract: Retinitis pigmentosa is a disease characterized by the loss of photoreceptor cells. The N-methyl-N-nitrosourea (MNU)-induced retinal degeneration model is widely used to study the mechanism of these retinal degenerative disorders because of its selective photoreceptor cell death. As for the cell death mechanism of MNU, calcium-calpain activation and lipid peroxidation processes are involved in the initiation of this cell death. Although such molecular mechanisms of the MNU-induced cell death have been described, the total image of the cell death is still obscure. Heat shock protein 70 (HSP70) has been shown to function as a chaperon molecule to protect cells against environmental and physiological stresses. In this study, we investigated the effect of geranylgeranylacetone (GGA), an accylic polyisoprenoid, on MNU-induced photoreceptor cell loss. HSP70 induction by GGA was effective against MNU-induced photoreceptor cell loss as a result of its ability to prevent HSP70 degradation. The data indicate that GGA may help to suppress the onset and progression of retinitis pigmentosa.
authors.affiliation: Graduate School and Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3 Minamitamagaki, 513-8670, Suzuka, Japan. koriyama@suzuka-u.ac.jp.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Koriyama
authors.affiliation: Wellness Promotion Science Center, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, 920-0942, Kanazawa, Japan. kazuhiro@staff.kanazawa-u.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ogai
authors.affiliation: Department of Clinical Laboratory Sciences, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, 920-0942, Kanazawa, Japan. sugitani@staff.kanazawa-u.ac.jp.
authors.forename: Kayo
authors.initials: K
authors.lastname: Sugitani
authors.affiliation: Department of Clinical Laboratory Sciences, Department of Molecular Neurobiology, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, 920-0942, Kanazawa, Japan. ef.ef.soylatte.ts@gmail.com.
authors.forename: Suguru
authors.initials: S
authors.lastname: Hisano
authors.affiliation: Department of Molecular Neurobiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, 920-8640, Kanazawa, Japan. satoru@med.kanazawa-u.ac.jp.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kato
mesh_terms: D000477:Alkylating Agents / Q000633:toxicity; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D004224:Diterpenes / Q000494:pharmacology*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008770:Methylnitrosourea / Q000633:toxicity*; D008810:Mice, Inbred C57BL; D020419:Photoreceptor Cells, Vertebrate / Q000187:drug effects* / Q000378:metabolism; D012174:Retinitis Pigmentosa / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000477:Alkylating Agents; D004224:Diterpenes; D018840:HSP70 Heat-Shock Proteins; D008770:Methylnitrosourea; C031049:geranylgeranylacetone
keywords: Geranylgeranylacetone; Heat shock protein 70; N-methyl-N-nitrosourea; Photoreceptor cell death; Retinitis pigmentosa