title: Effect of sinapic acid on 1,2 dimethylhydrazine induced aberrant crypt foci, biotransforming bacterial enzymes and circulatory oxidative stress status in experimental rat colon carcinogenesis.
abstract: OBJECTIVE
  This study was aimed to investigate the effect of sinapic acid (SA) on 1,2-dimethylhydrazine (DMH) induced experimental rat colon carcinogenesis.
  
  
  METHODS
  Rats were assorted into six groups, group 1 served as control, group 2 received SA (80 mg/kg b.w.) post orally every day until the end of the experimental period of 16 weeks, groups 3-6 rats were injected DMH (20 mg/kg b.w.) subcutaneously once a week for first four weeks. In addition, groups 4-6 rats received different doses of SA (20, 40 and 80 mg/kg b.w.).
  
  
  RESULTS
  Our results showed that DMH induced rats revealed significantly increased ACF development and multiplicity, which were significantly inhibited on supplementation with SA. Moreover, elevated levels/activities of circulatory oxidative stress markers, faecal and colonic mucosal bacterial enzymes were observed in DMH exposed rats, which were diminished on supplementation with SA.
  
  
  CONCLUSIONS
  Overall, our findings revealed that supplementation with SA offers significant protection against DMH induced rat colon carcinogenesis and the effect of SA at the dose of 40 mg/kg b.w. was more pronounced as compared to the other two doses. (Tab.5, Fig. 3, Ref. 46)
authors.forename: C
authors.initials: C
authors.lastname: Balaji
authors.forename: J
authors.initials: J
authors.lastname: Muthukumaran
authors.forename: N
authors.initials: N
authors.lastname: Nalini
mesh_terms: D019813:1,2-Dimethylhydrazine / Q000633:toxicity; D058739:Aberrant Crypt Foci / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D063646:Carcinogenesis / Q000139:chemically induced / Q000187:drug effects*; D002374:Catalase / Q000187:drug effects / Q000378:metabolism; D003106:Colon / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology*; D003373:Coumaric Acids / Q000494:pharmacology*; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009374:Neoplasms, Experimental; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D003373:Coumaric Acids; C073734:sinapinic acid; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D019813:1,2-Dimethylhydrazine
keywords: aberrant crypt foci; bacterial enzymes.; colon cancer; sinapic acid