title: [Association of TNF-alpha and IL-13 genes polymorphisms with bronchial asthma].
abstract: OBJECTIVE To assess the association of polymorphisms of TNF-alpha gene (rs1799724, rs1800630, rs1799964 and rs769178) and IL-13 gene (rs2158177 and rs1295687) with susceptibility to asthma among ethnic Chinese in Qingdao region. METHODS For 400 asthma patients and 200 healthy subjects, above polymorphisms were detected with a SNaPshot method. RESULTS For rs2158177, the frequency of genotype of GG in the asthma group was significantly lower than the control group (2.8% vs. 5%, OR = 0.31, 95%CI: 0.12-0.82, P = 0.021). No significant difference was detected in the genotypic frequencies for the remaining 5 polymorphisms between the two groups (All P > 0.05). CONCLUSION The study has indicated that rs2158177 polymorphism of the IL-13 gene is associated with asthma in ethnic Han Chinese from Qingdao. No association has been found between polymorphisms of TNF-alpha gene with susceptibility to asthma.
authors.affiliation: Department of Pneumology, Department of Cardiology, Qingdao Hiser Medical Center, Qingdao, Shangdong 266033, P.R. China. Email: at_mountain@163.com.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Liang
authors.forename: Zhaoshan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Zhongqiang
authors.initials: Z
authors.lastname: Ji
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Wang
authors.forename: Weilin
authors.initials: W
authors.lastname: Xue
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000235:genetics*; D005260:Female; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D018793:Interleukin-13; D014409:Tumor Necrosis Factor-alpha