title: The impact of intrauterine infection on fetal brain damage assessed by S100B protein concentrations in umbilical cord arteries.
abstract: OBJECTIVE
  To assess the impact of intrauterine infection on fetal brain damage by measuring S100B protein concentration in umbilical cord arteries.
  
  
  METHODS
  In the intrauterine infection cases determined by pathology of 25 deliveries (Group I) and non-infection cases of 35 deliveries as control (Group C), we compared gestational age at delivery, birth weight, fetal heart rate monitoring during labor, Apgar score, umbilical cord artery pH and S100B protein concentrations in umbilical arteries measured by two-site immunoradiometric assay kit.
  
  
  RESULTS
  (1) There was no significant correlation between pH and concentration of S100B protein. (2) Gestational age at delivery was found to be earlier in Group I, resulting in lower birth weights, when compared with Group C. (3) There was no significant difference between two groups concerning Apgar scores, pH. (4) S100B protein concentrations in Group I was significantly higher than those of Group C (3.9 7 ± 0.66 versus 1.8 9 ± 0.56 μg/L, p < 0.05). (5) The concentration of S100B protein in severe chorioamnionitis (CAM) cases were significantly higher than those of mild CAM and control cases.
  
  
  CONCLUSIONS
  Higher concentration of S100B protein in Group I suggests that intrauterine infection itself has a serious risk factor on fetal brain damage.
authors.affiliation: a Department of Obstetrics and Gynecology , Tokyo Women's Medical University Yachiyo Medical Center , Chiba , Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Masaoka
authors.affiliation: a Department of Obstetrics and Gynecology , Tokyo Women's Medical University Yachiyo Medical Center , Chiba , Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nakajima
authors.affiliation: a Department of Obstetrics and Gynecology , Tokyo Women's Medical University Yachiyo Medical Center , Chiba , Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Morooka
authors.affiliation: a Department of Obstetrics and Gynecology , Tokyo Women's Medical University Yachiyo Medical Center , Chiba , Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Tashiro
authors.affiliation: a Department of Obstetrics and Gynecology , Tokyo Women's Medical University Yachiyo Medical Center , Chiba , Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Wada
authors.affiliation: a Department of Obstetrics and Gynecology , Tokyo Women's Medical University Yachiyo Medical Center , Chiba , Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Maruta
authors.affiliation: a Department of Obstetrics and Gynecology , Tokyo Women's Medical University Yachiyo Medical Center , Chiba , Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Iwane
authors.affiliation: a Department of Obstetrics and Gynecology , Tokyo Women's Medical University Yachiyo Medical Center , Chiba , Japan.
authors.forename: Miwako
authors.initials: M
authors.lastname: Yamashiro
mesh_terms: D000328:Adult; D001034:Apgar Score; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D001927:Brain Diseases / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D015592:Immunoradiometric Assay; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012307:Risk Factors; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D014552:Urinary Tract Infections / Q000097:blood / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human
keywords: Fetal brain damage; S100B protein; intrauterine infection