title: Next generation dengue vaccines: A review of the preclinical development pipeline.
abstract: Dengue represents a significant and growing public health problem across the globe, with approximately half of the world's population at risk. The increasing and expanding burden of dengue has highlighted the need for new tools to prevent dengue, including development of dengue vaccines. Recently, the first dengue vaccine candidate was evaluated in Phase 3 clinical trials, and other vaccine candidates are under clinical evaluation. There are also a number of candidates in preclinical development, based on diverse technologies, with promising results in animal models and likely to move into clinical trials and could eventually be next-generation dengue vaccines. This review provides an overview of the various technological approaches to dengue vaccine development with specific focus on candidates in preclinical development and with evaluation in non-human primates.
authors.affiliation: Initiative for Vaccine Research, Department of Immunizations, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.
authors.forename: Kirsten S
authors.initials: KS
authors.lastname: Vannice
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Roehrig
authors.affiliation: Initiative for Vaccine Research, Department of Immunizations, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland. Electronic address: hombachj@who.int.
authors.forename: Joachim
authors.initials: J
authors.lastname: Hombach
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003715:Dengue / Q000453:epidemiology / Q000517:prevention & control*; D053059:Dengue Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D006801:Humans; D011323:Primates
chemical_list: D053059:Dengue Vaccines
keywords: Dengue vaccine; Vaccine development