title: Soluble Fermentable Dietary Fibre (Pectin) Decreases Caloric Intake, Adiposity and Lipidaemia in High-Fat Diet-Induced Obese Rats.
abstract: Consumption of a high fat diet promotes obesity and poor metabolic health, both of which may be improved by decreasing caloric intake. Satiety-inducing ingredients such as dietary fibre may be beneficial and this study investigates in diet-induced obese (DIO) rats the effects of high or low fat diet with or without soluble fermentable fibre (pectin). In two independently replicated experiments, young adult male DIO rats that had been reared on high fat diet (HF; 45% energy from fat) were given HF, low fat diet (LF; 10% energy from fat), HF with 10% w/w pectin (HF+P), or LF with 10% w/w pectin (LF+P) ad libitum for 4 weeks (n = 8/group/experiment). Food intake, body weight, body composition (by magnetic resonance imaging), plasma hormones, and plasma and liver lipid concentrations were measured. Caloric intake and body weight gain were greatest in HF, lower in LF and HF+P, and lowest in the LF+P group. Body fat mass increased in HF, was maintained in LF, but decreased significantly in LF+P and HF+P groups. Final plasma leptin, insulin, total cholesterol and triglycerides were lower, and plasma satiety hormone PYY concentrations were higher, in LF+P and HF+P than in LF and HF groups, respectively. Total fat and triglyceride concentrations in liver were greatest in HF, lower in LF and HF+P, and lowest in the LF+P group. Therefore, the inclusion of soluble fibre in a high fat (or low fat) diet promoted increased satiety and decreased caloric intake, weight gain, adiposity, lipidaemia, leptinaemia and insulinaemia. These data support the potential of fermentable dietary fibre for weight loss and improving metabolic health in obesity.
authors.affiliation: Ingestive Behaviour Group, Obesity & Metabolic Health Division, Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen AB21 9SB, Scotland, United Kingdom.
authors.forename: Clare L
authors.initials: CL
authors.lastname: Adam
authors.affiliation: Ingestive Behaviour Group, Obesity & Metabolic Health Division, Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen AB21 9SB, Scotland, United Kingdom.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Thomson
authors.affiliation: Ingestive Behaviour Group, Obesity & Metabolic Health Division, Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen AB21 9SB, Scotland, United Kingdom.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Williams
authors.affiliation: Ingestive Behaviour Group, Obesity & Metabolic Health Division, Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen AB21 9SB, Scotland, United Kingdom.
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Ross
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage*; D059305:Diet, High-Fat / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D002149:Energy Intake; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver; D008297:Male; D009765:Obesity / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D010368:Pectins / Q000008:administration & dosage*; D017207:Rats, Sprague-Dawley
chemical_list: D019440:Anti-Obesity Agents; D008055:Lipids; D010368:Pectins