title: [Early diagnosis of prostate cancer by combined use of Trp-p8 expression and PSA density of the transition zone].
abstract: OBJECTIVE
  To study the expression of the Trp-p8 protein in the prostate tissue of the PSA "grey zone" with different PSA density of the transition zone (PSADTZ) and explore the value of determining Trp-p8 expression and PSADTZ in the early diagnosis of prostate cancer (PCa).
  
  
  METHODS
  This study involved 30 cases of benign prostatic hyperplasia (BPH) and another 30 cases of PCa with different PSADTZ values. Using a data imaging and analysis system, we determined the expression levels of Trp-p8 in BPH and PCa tissues and analyzed their correlation with PSADTZ.
  
  
  RESULTS
  The expression of Trp-p8 was weak or negative in the BPH but strong in the PCa tissue and even stronger in the PCa tissue with high PSADTZ (F = 34. 05, P < 0.05).
  
  
  CONCLUSIONS
  The Trp-p8 protein is expressed differently in BPH and PCa tissues of the PSA " grey zone" and its expression is positively correlated with PSADTZ. Determination of the Trp-p8 expression and PSADTZ contributes to the early diagnosis of prostate cancer.
authors.forename: Xin-sheng
authors.initials: XS
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Pan-xing
authors.initials: PX
authors.lastname: Wu
authors.forename: Shui-jiao
authors.initials: SJ
authors.lastname: Liu
authors.forename: Jian-yu
authors.initials: JY
authors.lastname: Zhou
authors.forename: Shi-xiong
authors.initials: SX
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism*; D017430:Prostate-Specific Antigen / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D050053:TRPM Cation Channels / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D050053:TRPM Cation Channels; C425966:TRPM8 protein, human; D017430:Prostate-Specific Antigen