title: Cytoplasmic mRNA turnover and ageing.
abstract: Messenger RNA (mRNA) turnover that determines the lifetime of cytoplasmic mRNAs is a means to control gene expression under both normal and stress conditions, whereas its impact on ageing and age-related disorders has just become evident. Gene expression control is achieved at the level of the mRNA clearance as well as mRNA stability and accessibility to other molecules. All these processes are regulated by cis-acting motifs and trans-acting factors that determine the rates of translation and degradation of transcripts. Specific messenger RNA granules that harbor the mRNA decay machinery or various factors, involved in translational repression and transient storage of mRNAs, are also part of the mRNA fate regulation. Their assembly and function can be modulated to promote stress resistance to adverse conditions and over time affect the ageing process and the lifespan of the organism. Here, we provide insights into the complex relationships of ageing modulators and mRNA turnover mechanisms.
authors.affiliation: Biomedical Research Foundation of the Academy of Athens, Center of Basic Research II, Athens 11527, Greece; Faculty of Biology, School of Science, University of Athens, Athens, Greece.
authors.forename: Fivos
authors.initials: F
authors.lastname: Borbolis
authors.affiliation: Biomedical Research Foundation of the Academy of Athens, Center of Basic Research II, Athens 11527, Greece. Electronic address: synticha@bioacademy.gr.
authors.forename: Popi
authors.initials: P
authors.lastname: Syntichaki
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D014176:Protein Biosynthesis; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger
keywords: Ageing; P-body; Protein synthesis; Stress granule; mRNA decay