title: Cerebral perfusional effects of 1-year rivastigmine treatment in Alzheimer disease: a case report.
abstract: It is described the case of a 74-years-old woman with probable Alzheimer Disease who showed good clinical response to rivastigmine associated with relevant improvement of cerebral perfusion after 1 year of treatment. The single-photon emission computed tomography (SPECT) scan showed a significant improvement in cortical uptake of the tracer in temporo-parietal and frontal regions in comparison to the examination performed before the treatment.
authors.affiliation: Department of Cardiovascular, Respiratory,&nbsp;Nefrologic, Anaesthesiologic and Geriatric&nbsp;Sciences, Sapienza University of Rome, Italy.
authors.forename: Evaristo
authors.initials: E
authors.lastname: Ettorre
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Bersani
authors.affiliation: Department of Cardiovascular, Respiratory,&nbsp;Nefrologic, Anaesthesiologic and Geriatric&nbsp;Sciences, Sapienza University of Rome, Italy.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Colella
authors.affiliation: Department of Cardiovascular, Respiratory,&nbsp;Nefrologic, Anaesthesiologic and Geriatric&nbsp;Sciences, Sapienza University of Rome, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Servello
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors.forename: Amedeo
authors.initials: A
authors.lastname: Minichino
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Megna
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Liberatore
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Biondi
authors.affiliation: Department of Cardiovascular, Respiratory,&nbsp;Nefrologic, Anaesthesiologic and Geriatric&nbsp;Sciences, Sapienza University of Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Marigliano
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology*; D001921:Brain / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D000068836:Rivastigmine / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016896:Treatment Outcome
chemical_list: D002800:Cholinesterase Inhibitors; D000068836:Rivastigmine