title: Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis.
abstract: Pustulosis palmaris et plantaris or palmoplantar pustulosis (PPP) is a refractory pustular eruption of the palms and soles with unknown etiology. In addition to skin lesions, PPP patients may present with severe joint pain and pustulotic arthro-osteitis (PAO), especially of the sternoclavicular joint. PAO is sometimes regarded as a variant of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. Hence, macrolide and tetracycline antibiotics are used for the treatment of PPP with PAO. We report 3 cases of PPP with PAO that did not improve upon administration of macrolide antibiotics with NSAIDs. After administration of cefcapene pivoxil hydrochloride (CFPN-PI), a third-generation cephalosporin, the swelling and sternoclavicular joint pain were promptly reduced and dramatically improved in all 3 cases. We review the conventional antibiotic treatments used currently and propose CFPN-PI as a potentially new therapy for PPP or PPP + PAO.
authors.affiliation: Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Japan.
authors.forename: Masamoto
authors.initials: M
authors.lastname: Murakami
authors.forename: Kana
authors.initials: K
authors.lastname: Masuda
authors.forename: Ryo
authors.initials: R
authors.lastname: Utsunomiya
authors.forename: Fumiko
authors.initials: F
authors.lastname: Oda
authors.forename: Chika
authors.initials: C
authors.lastname: Namba
authors.forename: Koji
authors.initials: K
authors.lastname: Sayama
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000188:drug therapy*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy*; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C425944:cefcapene pivoxil hydrochloride