title: Systematic Review and Meta-Analysis of the Effects of Exercise for Those With Cancer-Related Lymphedema.
abstract: OBJECTIVE
  To evaluate the effects of exercise on cancer-related lymphedema and related symptoms, and to determine the need for those with lymphedema to wear compression during exercise.
  
  
  METHODS
  CINAHL, Cochrane, EBSCOhost, MEDLINE, PubMed, ProQuest Health and Medical Complete, ProQuest Nursing and Allied Health Source, ScienceDirect, and SPORTDiscus databases were searched for trials published before January 1, 2015.
  
  
  METHODS
  Randomized and nonrandomized controlled trials and single-group pre-post studies published in English were included. Twenty-one (exercise) and 4 (compression and exercise) studies met inclusion criteria.
  
  
  METHODS
  Data were extracted into tabular format using predefined data fields by 1 reviewer and assessed for accuracy by a second reviewer. Study quality was evaluated using the Effective Public Health Practice Project Quality Assessment Tool.
  
  
  RESULTS
  Data were pooled using a random-effects model to assess the effects of acute and long-term exercise on lymphedema and lymphedema-associated symptoms, with subgroup analyses for exercise mode and intervention length. There was no effect of exercise (acute or intervention) on lymphedema or associated symptoms, with standardized mean differences from all analyses ranging between -0.2 and 0.1 (P values ≥.22). Findings from subgroup analyses for exercise mode (aerobic, resistance, mixed, other) and intervention duration (>12wk or ≤12wk) were consistent with these findings-that is, no effect on lymphedema or associated symptoms. There were too few studies evaluating the effect of compression during regular exercise to conduct a meta-analysis.
  
  
  CONCLUSIONS
  Individuals with secondary lymphedema can safely participate in progressive, regular exercise without experiencing a worsening of lymphedema or related symptoms. However, there is insufficient evidence to support or refute the current clinical recommendation to wear compression garments during regular exercise.
authors.affiliation: School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Queensland, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia. Electronic address: b6.singh@qut.edu.au.
authors.forename: Ben
authors.initials: B
authors.lastname: Singh
authors.affiliation: School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Queensland, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
authors.forename: Tracey
authors.initials: T
authors.lastname: Disipio
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia; School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Peake
authors.affiliation: School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Queensland, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
authors.forename: Sandra C
authors.initials: SC
authors.lastname: Hayes
mesh_terms: D058128:Compression Bandages; D015444:Exercise; D006801:Humans; D008209:Lymphedema / Q000209:etiology / Q000628:therapy*; D009369:Neoplasms / Q000150:complications*
keywords: Exercise; Exercise therapy; Lymphedema; Neoplasms; Rehabilitation; Weight lifting