title: Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids.
abstract: The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.
authors.affiliation: Department of Drug Design, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.|Janssen Infectious Diseases BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium.
authors.forename: George P
authors.initials: GP
authors.lastname: Liao
authors.affiliation: Department of Drug Design, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.|Chemistry Department, Faculty of Science, Sohag University , Sohag 82524, Egypt.
authors.forename: Eman M M
authors.initials: EM
authors.lastname: Abdelraheem
authors.affiliation: Department of Drug Design, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Constantinos G
authors.initials: CG
authors.lastname: Neochoritis
authors.affiliation: Faculty of Chemistry, Jagiellonian University , 3 Ingardena Street, 30-060 Kraków, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kurpiewska
authors.affiliation: Faculty of Chemistry, Jagiellonian University , 3 Ingardena Street, 30-060 Kraków, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Kalinowska-Tłuścik
authors.affiliation: Janssen Infectious Diseases BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium.
authors.forename: David C
authors.initials: DC
authors.lastname: McGowan
authors.affiliation: Department of Drug Design, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D047028:Macrocyclic Compounds