title: [The life cycle of Rubella Virus].
abstract: Rubella virus (RV), an infectious agent of rubella, is the sole member of the genus Rubivirus in the family of Togaviridae. RV has a positive-stranded sense RNA as a genome. A natural host of RV is limited to human, and rubella is considered to be a childhood disease in general. When woman is infected with RV during early pregnancy, her fetus may develop severe birth defects known as congenital rubella syndrome. In this review, the RV life cycle from the virus entry to budding is illustrated in comparison with those of member viruses of the genus alphavirus in the same family. The multiple functions of the RV capsid protein are also introduced.
authors.affiliation: Department of Virology III, National Institute of Infectious Diseases.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Sakata
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Mori
mesh_terms: D000293:Adolescent; D000524:Alphavirus; D020816:Amino Acid Motifs; D036022:Capsid Proteins / Q000737:chemistry / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D016679:Genome, Viral; D006801:Humans; D007223:Infant; D008018:Life Cycle Stages; D008297:Male; D011247:Pregnancy; D017434:Protein Structure, Tertiary; D012409:Rubella / Q000151:congenital / Q000517:prevention & control; D012411:Rubella Vaccine; D012412:Rubella virus / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity; D057074:Virus Release
chemical_list: D036022:Capsid Proteins; D012411:Rubella Vaccine