title: Histiocytoid Sweet syndrome treated with azathioprine: a case report.
abstract: Histiocytoid Sweet syndrome (HSS) is a rare histologic variation of Sweet syndrome (SS) predominantly exhibiting mononuclear histiocytoid cells instead of neutrophils. We report a 22-year-old woman with HSS, who, after minimal improvement with colchicine and dapsone, had significant improvement of her cutaneous eruption and systemic symptoms following empiric treatment with azathioprine. Since azathioprine has historically been known to cause SS, this case highlights a previously unreported treatment response for the histiocytoid variant.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Miller
authors.forename: Nicole
authors.initials: N
authors.lastname: Lee
authors.affiliation: University of Alabama at Birmingham. nsami@uab.edu.
authors.forename: Naveed
authors.initials: N
authors.lastname: Sami
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use*; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006644:Histiocytes / Q000473:pathology*; D015614:Histiocytosis / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D035583:Rare Diseases; D012720:Severity of Illness Index; D016463:Sweet Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine