title: Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T.
abstract: OBJECTIVE
  To noninvasively assess liver fibrosis using combined-contrast-enhanced (CCE) magnetic resonance imaging (MRI) and texture analysis.
  
  
  METHODS
  In this IRB-approved, HIPAA-compliant prospective study, 46 adults with newly diagnosed HCV infection and recent liver biopsy underwent CCE liver MRI following intravenous administration of superparamagnetic iron oxides (ferumoxides) and gadolinium DTPA (gadopentetate dimeglumine). The image texture of the liver was quantified in regions-of-interest by calculating 165 texture features. Liver biopsy specimens were stained with Masson trichrome and assessed qualitatively (METAVIR fibrosis score) and quantitatively (% collagen stained area). Using L 1 regularization path algorithm, two texture-based multivariate linear models were constructed, one for quantitative and the other for quantitative histology prediction. The prediction performance of each model was assessed using receiver operating characteristics (ROC) and correlation analyses.
  
  
  RESULTS
  The texture-based predicted fibrosis score significantly correlated with qualitative (r = 0.698, P < 0.001) and quantitative (r = 0.757, P < 0.001) histology. The prediction model for qualitative histology had 0.814-0.976 areas under the curve (AUC), 0.659-1.000 sensitivity, 0.778-0.930 specificity, and 0.674-0.935 accuracy, depending on the binary classification threshold. The prediction model for quantitative histology had 0.742-0.950 AUC, 0.688-1.000 sensitivity, 0.679-0.857 specificity, and 0.696-0.848 accuracy, depending on the binary classification threshold.
  
  
  CONCLUSIONS
  CCE MRI and texture analysis may permit noninvasive assessment of liver fibrosis.
authors.affiliation: Departments of Radiology, University of California, San Diego, CA 92103, USA ; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Road, NE2.210B, Dallas, TX 75390-9085, USA.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yokoo
authors.affiliation: Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California, San Diego, CA 92093, USA.
authors.forename: Tanya
authors.initials: T
authors.lastname: Wolfson
authors.affiliation: Departments of Radiology, University of California, San Diego, CA 92103, USA ; Departments of Medicine, University of California, San Diego, CA 92103, USA ; Department of Target Therapy Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Iwaisako
authors.affiliation: Departments of Pathology, University of California, San Diego, CA 92103, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Peterson
authors.affiliation: Department of Pathology, Penn State Hershey Medical Center, Hershey, PA 17033, USA.
authors.forename: Haresh
authors.initials: H
authors.lastname: Mani
authors.affiliation: Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Goodman
authors.affiliation: Departments of Radiology, University of California, San Diego, CA 92103, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Changchien
authors.affiliation: Departments of Radiology, University of California, San Diego, CA 92103, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Middleton
authors.affiliation: Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California, San Diego, CA 92093, USA.
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Gamst
authors.affiliation: Departments of Medicine, University of California, San Diego, CA 92103, USA.
authors.forename: Sameer M
authors.initials: SM
authors.lastname: Mazhar
authors.affiliation: Departments of Radiology, University of California, San Diego, CA 92103, USA.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kono
authors.affiliation: Departments of Medicine, University of California, San Diego, CA 92103, USA ; VA San Diego Healthcare System, San Diego, CA 92161, USA.
authors.forename: Samuel B
authors.initials: SB
authors.lastname: Ho
authors.affiliation: Departments of Radiology, University of California, San Diego, CA 92103, USA.
authors.forename: Claude B
authors.initials: CB
authors.lastname: Sirlin
mesh_terms: D003287:Contrast Media; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D003287:Contrast Media