title: Early intrauterine development of mixed giant intracranial teratoma in newborn: a case report.
abstract: Teratoma is one of the most frequent fetal intracranial tumors, but it usually grows very quickly and the fetus is generally a stillborn. Rare cases have slow development or are located in areas that afford immediate surgery after birth with variable chances of survival. Even more rare cases survive days or weeks, but with no chance of surgical treatment and with prolonged palliative care. We present a 34 weeks premature infant, born by C-section with a giant intracranial tumor, whose origin could not be ascertained, occupied almost all-intracranial space and survived 25 days with supportive care. The histological examination established a G3 mixed teratoma, predominantly with immature cells from all three embryonic layers. The cerebellum was normal and infra-mesencephalic structures were present. The infant presented with severe anemia and mild respiratory distress, and was out of neurosurgical therapeutic resources. Antenatal examination was normal until 30 weeks, when fetal ultrasound described a degree of hydrocephalus, but no tumor was individualized.
  
  
  CONCLUSIONS
  G3 type complex teratoma, even rare, can be localized at cerebral level and get giant development and growth only in the third trimester of pregnancy, ending with a neonate that has no chance of survival. Such cases cannot benefit of therapeutic interruption of pregnancy and generate serious difficulties for parents and clinicians.
authors.affiliation: Department of Mother and Child Medicine, Division of Neonatology, "Grigore T. Popa" University of Medicine and Pharmacy, "Cuza Voda" Clinical Hospital of Obstetrics and Gynecology, Iassy, Romania; luminita.paduraru@gmail.com.
authors.forename: Luminiţa
authors.initials: L
authors.lastname: Păduraru
authors.forename: Daniela Claudia
authors.initials: DC
authors.lastname: Scripcaru
authors.forename: Gabriela Ildiko
authors.initials: GI
authors.lastname: Zonda
authors.forename: Andreea Luciana
authors.initials: AL
authors.lastname: Avasiloaiei
authors.forename: Maria
authors.initials: M
authors.lastname: Stamatin
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002356:Cartilage / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D002585:Cesarean Section; D004848:Epithelium / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000473:pathology; D007231:Infant, Newborn; D007234:Infant, Premature; D007422:Intestines / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011379:Prognosis; D013724:Teratoma / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D016216:Ultrasonography, Prenatal