title: Skin-Directed Therapies in Cutaneous T-Cell Lymphoma.
abstract: Early stage mycosis fungoides represents the most common clinical presentation of cutaneous lymphoma, with skin-directed therapies long established in its treatment. These therapies continue to change as new treatment regimens emerge. Other skin-directed treatments include light and radiation therapy. Therapies with higher levels of evidence and less systemic toxicity are usually preferred as first-line treatment. However, even these established therapies, like topical corticosteroids and carmustine, lack randomized clinical trials to establish their efficacy. Research is also needed to further define the role of combination topical therapies and how skin-directed therapies can be used as adjuvants to systemic medications.
authors.affiliation: Department of Dermatology, University of Minnesota, 516 Delaware Street S.E., Mail Code 98, Phillips-Wangensteen Building, Suite 4-240, Minneapolis, MN 55455, USA.
authors.forename: Cuong V
authors.initials: CV
authors.lastname: Nguyen
authors.affiliation: Department of Dermatology, University of Minnesota, 516 Delaware Street S.E., Mail Code 98, Phillips-Wangensteen Building, Suite 4-240, Minneapolis, MN 55455, USA. Electronic address: Bohja003@umn.edu.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Bohjanen
mesh_terms: D000279:Administration, Cutaneous; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009182:Mycosis Fungoides / Q000188:drug therapy*; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use; D012751:Sezary Syndrome / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D003879:Dermatologic Agents; D012176:Retinoids
keywords: Cancer; Lymphoma; Mycosis fungoides; Skin-directed therapy; T cell