title: Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy.
abstract: Weight gain and metabolic changes have been related to survival of early breast cancer patients (EBC). ''However, factors influencing metabolism post-diagnosis are not fully understood. We measured anthropometric [body mass index (BMI), body weight, waist and hip circumferences, and waist-to-hip ratio] and metabolic (levels of insulin, glucose, H1Ac, total, HDL, and LDL cholesterol, triglycerides, and the homeostasis model assessment score [HOMA]) parameters in 433 pre- and post-menopausal women with EBC at diagnosis and 3, 6, 9, 12, and 24 months thereafter. At diagnosis, compared with post-menopausal women, pre-menopausal patients were more likely to be leaner and to have a lower BMI, smaller waist and hip circumferences, and waist-to-hip ratio. They had also lower glucose, HbA1c, and triglyceride levels and a lower HOMA score. Furthermore, they were more likely to have an estrogen- and/or progesterone-positive tumor and a higher proliferating breast cancer. During the first two post-diagnosis years, all women showed a significant increase of weight (+0.72 kg/year, P < 0.001), waist circumference (+1.53 cm/year, P < 0.001), and plasma levels of LDL cholesterol (+5.4 mg/dl per year, P = 0.045) and triglycerides (+10.73 mg/dl per year, P = 0.017). In patients receiving chemotherapy only, there was a significant increase in hip circumference (+3.16 cm/year, P < 0.001) and plasma cholesterol levels (+21.26 mg/dl per year, P < 0.001). We showed that weight, body fat distribution, and lipid profile changed in EBC patients receiving adjuvant therapy. These changes occurred during the first 2 years after diagnosis and were not specifically related to chemotherapy, menopausal status, or initial body weight.
authors.affiliation: Department of Clinical Medicine and Surgery, Oncology Division, University of Naples "Federico II" Medical School, Via S. Pansini 5, 80131, Naples, Italy. grazia.arpino@unina.it.
authors.forename: Grazia
authors.identifier: http://orcid.org/0000-0002-4074-2530
authors.initials: G
authors.lastname: Arpino
authors.affiliation: Department of Clinical Medicine and Surgery, Oncology Division, University of Naples "Federico II" Medical School, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: De Angelis
authors.affiliation: Department of Clinical Medicine and Surgery, Oncology Division, University of Naples "Federico II" Medical School, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Buono
authors.affiliation: Endocrinology Division, University of Naples "Federico II" Medical School, Naples, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.affiliation: Department of Clinical Medicine and Surgery, Oncology Division, University of Naples "Federico II" Medical School, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Giuliano
authors.affiliation: Department of Clinical Medicine and Surgery, Oncology Division, University of Naples "Federico II" Medical School, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Malgieri
authors.affiliation: Department of Clinical Medicine and Surgery, Oncology Division, University of Naples "Federico II" Medical School, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Cicala
authors.affiliation: Department of Breast Medical Oncology, G. Pascale National Cancer Institute, Naples, Italy.
authors.forename: Michelino
authors.initials: M
authors.lastname: De Laurentiis
authors.affiliation: Department of Surgery, University of Naples "Federico II" Medical School, Naples, Italy.
authors.forename: Antonello
authors.initials: A
authors.lastname: Accurso
authors.affiliation: Division of Epidemiology, G. Pascale National Cancer Institute, Naples, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Crispo
authors.affiliation: Department of Surgery, University of Naples "Federico II" Medical School, Naples, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Limite
authors.affiliation: Department of Clinical Medicine and Surgery, Oncology Division, University of Naples "Federico II" Medical School, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Lauria
authors.affiliation: Department of Clinical and Molecular Pathology, University of Naples "Federico II" Medical School, Naples, Italy.
authors.forename: Bianca Maria
authors.initials: BM
authors.lastname: Veneziani
authors.affiliation: Department of Clinical Medicine and Surgery, Oncology Division, University of Naples "Federico II" Medical School, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Forestieri
authors.affiliation: Department of Epidemiology, University of Naples "Federico II" Medical School, Naples, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Bruzzese
authors.affiliation: Department of Clinical Medicine and Surgery, Oncology Division, University of Naples "Federico II" Medical School, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Sabino
authors.initials: S
authors.lastname: De Placido
mesh_terms: D000328:Adult; D001786:Blood Glucose; D050218:Body Fat Distribution; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy* / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D017698:Postmenopause; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014280:Triglycerides
keywords: Adjuvant therapy; Body weight and composition; Breast cancer; Glucose and lipid metabolism; Menopausal status