title: Lipid droplets and associated proteins in the skin: basic research and clinical perspectives.
abstract: Lipid droplets (LDs), the major organelles handling fat storage, comprise a hydrophobic neutral lipid core surrounded by a phospholipid monolayer embedded with a protein miscellany. Although lipids of the stratum corneum are essential for the skin barrier, and progressive lipid accumulation culminating in cell disruption is the hallmark of sebaceous differentiation, only a few studies touched on skin LD and associated proteins so far. Here, after briefly introducing the basic facts about LD and associated proteins, we discuss how forthcoming studies may unveil novel players in skin lipid metabolism and candidate target proteins for treating skin diseases.
authors.affiliation: Gene Center, Institute of Molecular Animal Breeding and Biotechnology, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany. marlon.schneider@lmu.de.
authors.forename: Marlon R
authors.initials: MR
authors.lastname: Schneider
authors.affiliation: Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, People's Republic of China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D000078404:Epidermal Cells; D004817:Epidermis / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D066292:Lipid Droplets / Q000378:metabolism*; D050356:Lipid Metabolism / Q000502:physiology*; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012627:Sebaceous Glands / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; C502539:CIDEA protein, human; C112511:CIDEB protein, human; C472088:CIDEC protein, human; D002352:Carrier Proteins; D000070778:Perilipin-1; D010750:Phosphoproteins; D011506:Proteins
keywords: Lipid droplets; Perilipins; Sebaceous glands; Stratum corneum