title: Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression.
abstract: Histone lysine acetylation is well known for being important in the epigenetic regulation of gene expression in eukaryotic cells. Recent studies have uncovered a plethora of acetylated proteins involved in important metabolic pathways, such as photosynthesis and respiration in plants. Enzymes involved in histone acetylation and deacetylation are being identified as regulators of acetylation of metabolic enzymes. Importantly, key metabolites, such as acetyl-CoA and NAD(+), are involved in protein acetylation and deacetylation processes, and their cellular levels may regulate the activity of histone acetyltransferases (HAT) and deacetylases (HDAC). Further research is required to determine whether and how HATs and HDACs sense cellular metabolite signals to control gene expression and metabolic enzyme activity through lysine acetylation and deacetylation.
authors.affiliation: Institute of Plant Sciences Paris-Saclay (IPS2), University Paris-sud 11, 91405 Orsay, France.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Institute of interdisciplinary Scientific Research, Jianghan University, 430056, Wuhan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Institute of Plant Sciences Paris-Saclay (IPS2), University Paris-sud 11, 91405 Orsay, France. Electronic address: dao-xiu.zhou@u-psud.fr.
authors.forename: Dao-Xiu
authors.initials: DX
authors.lastname: Zhou
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism; D000107:Acetylation; D044127:Epigenesis, Genetic; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010944:Plants / Q000201:enzymology*
chemical_list: D006657:Histones; D009243:NAD; D000105:Acetyl Coenzyme A; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases; D008239:Lysine
keywords: HAT; HDAC; NAD(+); acetyl-CoA; gene expression; metabolism