title: Characterization of Five Zoonotic Streptococcus suis Strains from Germany, Including One Isolate from a Recent Fatal Case of Streptococcal Toxic Shock-Like Syndrome in a Hunter.
abstract: A Streptococcus suis isolate from a German hunter with streptococcal toxic shock-like syndrome (STSLS) and four additional zoonotic isolates were genotyped as mrp(+) epf* (variant 1890) sly(+) cps2(+). All five zoonotic German strains were characterized by high multiplication in human blood samples ex vivo, but induction of only low levels of proinflammatory cytokines compared to a Chinese STSLS strain.
authors.affiliation: Hessian State Laboratory, Department of Veterinary Medicine, Giessen, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Eisenberg
authors.affiliation: Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Marburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Hudemann
authors.affiliation: Institute of Medical Microbiology, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: Hamid M
authors.initials: HM
authors.lastname: Hossain
authors.affiliation: Hessian State Laboratory, Department of Veterinary Medicine, Giessen, Germany.
authors.forename: Angela
authors.initials: A
authors.lastname: Hewer
authors.affiliation: Medical Clinic II, Justus Liebig University Giessen, Gissen, Germany.
authors.forename: Khodr
authors.initials: K
authors.lastname: Tello
authors.affiliation: Medical Clinic II, Justus Liebig University Giessen, Gissen, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Bandorski
authors.affiliation: Central Facility for Microscopy, Helmholtz Centre for Infection Research, Braunschweig, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Rohde
authors.affiliation: Institute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Valentin-Weigand
authors.affiliation: Institute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany Institute for Bacteriology and Mycology, Centre of Infectious Diseases, College of Veterinary Medicine, University Leipzig, Leipzig, Germany christoph.baums@vetmed.uni-leipzig.de.
authors.forename: Christoph Georg
authors.initials: CG
authors.lastname: Baums
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D005838:Genotype; D005858:Germany; D006801:Humans; D012772:Shock, Septic / Q000382:microbiology; D013290:Streptococcal Infections / Q000382:microbiology* / Q000662:veterinary*; D017011:Streptococcus suis / Q000145:classification* / Q000235:genetics* / Q000254:growth & development / Q000302:isolation & purification
chemical_list: D016207:Cytokines