title: [First report of invasive fungal disease by Candida fabianii in a non-neonatal paediatric patient].
abstract: BACKGROUND
  Invasive fungal diseases have increased in recent years. Candida species are the most common aetiology. Candida albicans, Candida parapsilosis, Candida tropicalis, Candida glabrata and Candida krusei are the cause of most of them. The aim of this work is to describe the first isolation of Candida fabianii in the blood of a non-neonatal paediatric patient.
  
  
  METHODS
  A 2 year-old male with short bowel syndrome, severe malnutrition, and hypophosphataemic rickets deficiency was admitted to paediatric intensive care due to a respiratory tract infection and suspicion of an intestinal pseudo-obstruction. He received several cycles of broad-spectrum antibiotics for several infections due to Pseudomonas aeruginosa and Escherichia coli. After the surgical correction of the intestinal disorder he suffered a new episode of sepsis where yeasts were isolated by culture. The species identification was performed by means of mass spectrometry (MALDI-TOF system, Bruker Daltonic). The identity of the isolate was C.fabianii (anamorph)/Pichia fabianii (teleomorph) with a score of 2.149. Antifungal treatment with caspofungin was prescribed, with good progress of the patient.
  
  
  CONCLUSIONS
  Molecular techniques are important for the identification of these species, although mass spectrometry offered a reliable and rapid diagnosis. Treatment with caspofungin was effective.
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Puerta del Mar, Cádiz, España. Electronic address: carlosflogon@gmail.com.
authors.forename: Jose Carlos
authors.initials: JC
authors.lastname: Flores-González
authors.affiliation: Servicio de Microbiología, Hospital Universitario Puerta del Mar, Cádiz, España.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Guerrero-Lozano
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Puerta del Mar, Cádiz, España.
authors.forename: Juan Jesús
authors.initials: JJ
authors.lastname: Pérez-Guerrero
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Puerta del Mar, Cádiz, España.
authors.forename: Arturo
authors.initials: A
authors.lastname: Hernández-González
authors.affiliation: Servicio de Microbiología, Hospital Universitario Puerta del Mar, Cádiz, España.
authors.forename: Fátima
authors.initials: F
authors.lastname: Galán-Sánchez
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Puerta del Mar, Cádiz, España.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Quintero-Otero
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Puerta del Mar, Cádiz, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rubio-Quiñones
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Puerta del Mar, Cádiz, España.
authors.forename: Servando
authors.initials: S
authors.lastname: Pantoja-Rosso
mesh_terms: D058365:Candidiasis, Invasive / Q000175:diagnosis / Q000188:drug therapy; D002675:Child, Preschool; D006801:Humans; D008297:Male
keywords: Candida fabianii; Candidaemia; Candidemia; Caspofungin; Caspofungina; Infección fúngica invasora; Invasive fungal diseases