title: Occurrence of Deep Vein Thrombosis among Hospitalized Non-Surgical Japanese Patients.
abstract: OBJECTIVE
  To estimate the frequency of deep vein thrombosis (DVT) among non-surgical inpatients, and to evaluate the D-dimer assay as a screening tool for DVT.
  
  
  METHODS
  Subjects were non-surgical inpatients aged 20 years or older who had been bedridden for at least 24 hours and had moderate-to-high risk factors for DVT. We assessed the presence of DVT by venous ultrasonography. Patients who received a diagnosis of venous thromboembolism (VTE) before admission, who had symptoms or findings of VTE at admission, or who had surgery or trauma within the past 3 months before admission were excluded.
  
  
  RESULTS
  DVT was confirmed in 96 of 525 patients (18.3%). In a logistic regression analysis, longer duration of hospitalization, higher D-dimer value, and history of cancer surgery were significantly associated with the occurrence of DVT. The D-dimer assay showed high sensitivity (96.1%) and high negative predictive value (97.6%).
  
  
  CONCLUSIONS
  Non-surgical inpatients with a long-term hospitalization or history of cancer surgery have a risk for DVT, and need to be considered for added DVT preventive measures as recommended in the prevention guidelines. In addition, the D-dimer assay is beneficial for the screening of DVT in medical practice.
authors.affiliation: Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Yamada
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hanzawa
authors.affiliation: Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.affiliation: Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Mashio
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Internal Medicine, Niigata National Hospital, National Hospital Organization, Kashiwazaki, Niigata, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Ikura
authors.affiliation: Development & Medical Affairs Division, GlaxoSmithKline K.K., Tokyo, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Development & Medical Affairs Division, GlaxoSmithKline K.K., Tokyo, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kaise
authors.affiliation: Development & Medical Affairs Division, GlaxoSmithKline K.K., Tokyo, Japan.
authors.forename: Hiromu
authors.initials: H
authors.lastname: Nakajima
authors.affiliation: Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ito
keywords: deep vein thrombosis; epidemiology; non-surgical patients; venous thromboembolism