title: The Biology and Clinical Utility of EBV Monitoring in Blood.
abstract: Epstein-Barr virus (EBV) DNA in blood can be quantified in peripheral blood mononuclear cells, in circulating cell-free (CCF) DNA specimens, or in whole blood. CCF viral DNA may be actively released or extruded from viable cells, packaged in virions or passively shed from cells during apoptosis or necrosis. In infectious mononucleosis, viral DNA is detected in each of these kinds of specimens, although it is only transiently detected in CCF specimens. In nasopharyngeal carcinoma, CCF EBV DNA is an established tumor marker. In EBV-associated Hodgkin lymphoma and in EBV-associated extranodal NK-/T-cell lymphoma, there is growing evidence for the utility of CCF DNA as a tumor marker.
authors.affiliation: Department of Oncology, Johns Hopkins School of Medicine, 389 CRB1 1650 Orleans, Baltimore, MD, 21287, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kanakry
authors.affiliation: Department of Oncology, Johns Hopkins School of Medicine, 389 CRB1 1650 Orleans, Baltimore, MD, 21287, USA. rambind1@jhmi.edu.
authors.forename: Richard
authors.initials: R
authors.lastname: Ambinder
mesh_terms: D004279:DNA, Viral / Q000097:blood* / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000097:blood* / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D014779:Virus Replication
chemical_list: D004279:DNA, Viral
keywords: Circulating cell‐free DNA; EBV monitoring; Nasopharyngeal cancer; Plasma EBV DNA; Tumor marker