title: [Advances in research of SCARB2 functions and related disorders].
abstract: SCARB2 (scavenger receptor class B, member 2) is a lysosomal membrane glucoprotein, which is encoded by SCARB2 gene. It takes vital parts in the physiological and pathological processes including the transportation of beta-glucocerebrosidase to the lysosome, infection of EV71 and load-induced cardiac myocyte hypertrophy. This article has reviewed the molecular structure and functions of SCARB2 gene and its protein, as well as their relationship with diseases.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China. Email: wjling8002@126.com.
authors.forename: Miao
authors.initials: M
authors.lastname: He
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Beisha
authors.initials: B
authors.lastname: Tang
authors.forename: Junling
authors.initials: J
authors.lastname: Wang
mesh_terms: D006232:Hand, Foot and Mouth Disease / Q000235:genetics; D006801:Humans; D051907:Lysosomal Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D020191:Myoclonic Epilepsies, Progressive / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics; D051116:Receptors, Scavenger / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
chemical_list: D051907:Lysosomal Membrane Proteins; D051116:Receptors, Scavenger; C074299:SCARB2 protein, human