title: Wingspan Stenting for Severe Symptomatic Intracranial Atherosclerotic Stenosis in 433 Patients Treated at a Single Medical Center.
abstract: OBJECTIVE
  To investigate the safety and outcome of intracranial stenting for intracranial atherosclerotic stenosis (IAS).
  
  
  METHODS
  Between July 2007 and April 2013, 433 consecutive patients with IAS > 70% underwent intracranial Wingspan stenting, and the data were prospectively analyzed.
  
  
  RESULTS
  Intracranial stenting was successful in 429 patients (99.1%), and the mean stenosis rate was improved from prestenting (82.3 ± 7.6)% to poststenting (16.6 ± 6.6)%. During the 30-day perioperative period, 29 patients (6.7%) developed stroke. The total perioperative stroke rate was significantly (P < 0.01) higher in the basilar artery area than in others, whereas the hemorrhagic stroke rate was significantly (P < 0.05) greater in the middle cerebral artery area than in others. The experience accumulation stage (13%) had a significantly (P < 0.05) higher stroke rate than the technical maturation stage (4.8%). Clinical follow-up 6-69 months poststenting revealed ipsilateral stroke in 20 patients (5.5%). The one- and two-year cumulative stroke rates were 9.5% and 11.5%, respectively; the two-year cumulative stroke rate was significantly (P < 0.05) greater in the experience accumulation stage (18.8%) than in the technical maturation stage (9.1%).
  
  
  CONCLUSIONS
  Wingspan stenting for intracranial atherosclerotic stenosis is safe and the long-term stroke rate after stenting is low in a Chinese subpopulation.
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Tian-Xiao
authors.initials: TX
authors.lastname: Li
authors.affiliation: Department of Medical Research, Shijiazhuang First Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China.
authors.forename: Bu-Lang
authors.initials: BL
authors.lastname: Gao
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Dong-Yang
authors.initials: DY
authors.lastname: Cai
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Zi-Liang
authors.initials: ZL
authors.lastname: Wang
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Liang-Fu
authors.initials: LF
authors.lastname: Zhu
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Jiang-Yu
authors.initials: JY
authors.lastname: Xue
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Bai
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Ying-Kun
authors.initials: YK
authors.lastname: He
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D003251:Constriction, Pathologic / Q000628:therapy; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015607:Stents; D016896:Treatment Outcome; D055815:Young Adult