title: Motors, anchors, and connectors: orchestrators of organelle inheritance.
abstract: Organelle inheritance is a process whereby organelles are actively distributed between dividing cells at cytokinesis. Much valuable insight into the molecular mechanisms of organelle inheritance has come from the analysis of asymmetrically dividing cells, which transport a portion of their organelles to the bud while retaining another portion in the mother cell. Common principles apply to the inheritance of all organelles, although individual organelles use specific factors for their partitioning. Inheritance factors can be classified as motors, which are required for organelle transport; anchors, which immobilize organelles at distinct cell structures; or connectors, which mediate the attachment of organelles to motors and anchors. Here, we provide an overview of recent advances in the field of organelle inheritance and highlight how motor, anchor, and connector molecules choreograph the segregation of a multicopy organelle, the peroxisome. We also discuss the role of organelle population control in the generation of cellular diversity.
authors.affiliation: Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada; email: rick.rachubinski@ualberta.ca.
authors.forename: Barbara
authors.initials: B
authors.lastname: Knoblach
authors.affiliation: Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada; email: rick.rachubinski@ualberta.ca.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Rachubinski
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D048749:Cytokinesis / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins; D015388:Organelles / Q000502:physiology*; D020675:Peroxisomes / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000502:physiology
chemical_list: D008565:Membrane Proteins
keywords: Saccharomyces cerevisiae; organelle division; organelle population control; organelle retention; organelle transport; peroxisomes