title: Intradural-extramedullary haemangioblastoma with paraspinal extension in a dog.
abstract: METHODS
  An 8-year-old spayed female cross-breed dog was evaluated following a 2-month history of thoracic limb weakness. Neurological examination revealed a spinal cord lesion between C1 and C5 segments. Magnetic resonance imaging (MRI) revealed that almost 70% of the spinal canal between C1 and C2 was occupied by an intradural extramedullary mass that was connected to a paraspinal mass from the cranial aspect of C2 to the cranial aspect of C3. The dog was anaesthetised and a dorsal, right-sided hemilaminectomy was performed. A durotomy was performed to expose a multilobular mass located principally along the right dorsal-lateral aspect of the spinal cord. The mass did not appear to infiltrate the cord parenchyma. The abnormal tissue was removed as completely as possible using gentle dissection and submitted for histological evaluation. The histological findings were consistent with an intradural-extramedullary haemangioblastoma with paraspinal extension. Following surgery, no neurological deterioration was detected. A metronomic-dosing chemotherapy protocol was administered to prevent progression or recurrence of the tumour. Follow-up MRI studies were performed 3, 6 and 12 months after the surgery, confirming complete tumour removal and the absence of recurrence.
  
  
  CONCLUSIONS
  Haemangioblastoma is an extremely rare neoplasm in animals and only two cases of this tumour have been reported, but in other anatomical locations. Haemangioblastomas in human patients are more commonly located in the cerebellum and intradural-extramedullary growth is extremely rare. The dog in this study responded favourably to combined surgery and metronomic chemotherapy and was clinically normal 1 year after surgery.
authors.affiliation: Veterinary University Hospital, School of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Binanti
authors.affiliation: Veterinary University Hospital, School of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.
authors.forename: D
authors.initials: D
authors.lastname: De Zani
authors.affiliation: Veterinary University Hospital, School of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Fantinato
authors.affiliation: Private practitioner, Bergamo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Allevi
authors.affiliation: Veterinary University Hospital, School of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Sironi
authors.affiliation: Veterinary University Hospital, School of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.
authors.forename: D D
authors.initials: DD
authors.lastname: Zani
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D066193:Cervical Cord / Q000473:pathology / Q000601:surgery; D002574:Cervical Vertebrae / Q000473:pathology* / Q000601:surgery*; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D004285:Dogs; D005260:Female; D018325:Hemangioblastoma / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D007796:Laminectomy / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: dogs; haemangioblastoma; immunohistochemistry; magnetic resonance imaging; spinal neoplasm