title: Fragility Fractures in Patients with Rheumatoid Arthritis and Osteoarthritis Compared with the General Population.
abstract: OBJECTIVE
  To determine the rate ratios of hip and distal radius fractures in patients with rheumatoid arthritis (RA), hip osteoarthritis (OA), and knee OA.
  
  
  METHODS
  Cohort study using healthcare data (1998-2012) covering the entire population of the Skåne region of Sweden.
  
  
  RESULTS
  We found an increased rate of hip fracture in both female [standardized fracture rate ratio (SFR) 1.54, 95% CI 1.40-1.70] and male patients with RA (SFR 1.81, 95% CI 1.51-2.17). The hip fracture rate in female OA was reduced by 10-20%, and trochanteric fracture tended to have a higher rate ratio compared with the cervical.
  
  
  CONCLUSIONS
  The 50-80% increased rate of hip fracture adds to the total burden of RA while the shifted distribution of cervical/trochanteric fractures in OA is in support of subchondral bone alterations.
authors.affiliation: From the Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan; Orthopedics, Department of Clinical Sciences, Lund University; Epidemiology and Register Centre South, Skåne University Hospital, Region Skåne, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA.Y. Yamamoto, PT, Department of Rehabilitation, Nagoya University Hospital; A. Turkiewicz, MSc, Orthopedics, Department of Clinical Sciences, Lund University; H. Wingstrand, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University; M. Englund, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University, and Epidemiology and Register Centre South, Skåne University Hospital, and Clinical Epidemiology Research and Training Unit, Boston University School of Medicine.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: From the Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan; Orthopedics, Department of Clinical Sciences, Lund University; Epidemiology and Register Centre South, Skåne University Hospital, Region Skåne, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA.Y. Yamamoto, PT, Department of Rehabilitation, Nagoya University Hospital; A. Turkiewicz, MSc, Orthopedics, Department of Clinical Sciences, Lund University; H. Wingstrand, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University; M. Englund, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University, and Epidemiology and Register Centre South, Skåne University Hospital, and Clinical Epidemiology Research and Training Unit, Boston University School of Medicine.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Turkiewicz
authors.affiliation: From the Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan; Orthopedics, Department of Clinical Sciences, Lund University; Epidemiology and Register Centre South, Skåne University Hospital, Region Skåne, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA.Y. Yamamoto, PT, Department of Rehabilitation, Nagoya University Hospital; A. Turkiewicz, MSc, Orthopedics, Department of Clinical Sciences, Lund University; H. Wingstrand, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University; M. Englund, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University, and Epidemiology and Register Centre South, Skåne University Hospital, and Clinical Epidemiology Research and Training Unit, Boston University School of Medicine.
authors.forename: Hans
authors.initials: H
authors.lastname: Wingstrand
authors.affiliation: From the Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan; Orthopedics, Department of Clinical Sciences, Lund University; Epidemiology and Register Centre South, Skåne University Hospital, Region Skåne, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA.Y. Yamamoto, PT, Department of Rehabilitation, Nagoya University Hospital; A. Turkiewicz, MSc, Orthopedics, Department of Clinical Sciences, Lund University; H. Wingstrand, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University; M. Englund, MD, PhD, Orthopedics, Department of Clinical Sciences, Lund University, and Epidemiology and Register Centre South, Skåne University Hospital, and Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. martin.englund@med.lu.se.
authors.forename: Martin
authors.initials: M
authors.lastname: Englund
mesh_terms: D000367:Age Factors; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016022:Case-Control Studies; D005260:Female; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D006620:Hip Fractures / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D015207:Osteoarthritis, Hip / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D020370:Osteoarthritis, Knee / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D011859:Radiography; D011885:Radius Fractures / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D012016:Reference Values; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology
chemical_list: D018501:Antirheumatic Agents
keywords: EPIDEMIOLOGY; FRACTURES; OSTEOARTHRITIS; OSTEOPOROSIS; RHEUMATOID ARTHRITIS