title: Influence of adiponectin gene variants and plasma fatty acids on systemic inflammation state association-A cross-sectional population-based study, São Paulo, Brazil.
abstract: METHODS
  Interactions between adiponectin genetic variants and plasma fatty acid profile can modulate plasma inflammatory biomarker concentration and the risk for metabolic diseases. The aim of this study was to investigate the interaction between single nucleotide polymorphisms of the adiponectin gene and plasma fatty acid profile in modulating the odds for systemic inflammation in a cross-sectional population-based study.
  
  
  RESULTS
  Inflammatory patterns comprised 11 inflammatory biomarkers. Among participants of the Health Survey of São Paulo, 262 adults (19-59 years) met the inclusion criteria. Anthropometric parameters, blood pressure, plasma inflammatory biomarker concentration, and fatty acid profile were measured and five single nucleotide polymorphisms of the adiponectin gene (rs2241766, rs1501299, rs16861209, rs17300539, and rs266729) genotyped. Individuals in the upper 50th percentile for plasma araquidonic acid, n-3 highly unsaturated fatty acid and estimated delta-5-desaturase activity, had reduced odds of being in the inflammatory cluster (OR (95% CI) = 0.55 (0.32-0.95), 0.50 (0.28-0.88) and 0.48 (0.28-0.83), respectively). Gene-plasma fatty acid profile interaction was found between rs2241766 and n-3 (p = 0.019), rs16861209 and araquidonic acid and docosapentaenoic acid (p = 0.044, p = 0.037, respectively), and rs17300539 and saturated fatty acid (p = 0.019).
  
  
  CONCLUSIONS
  Plasma fatty acid profile can interact with adiponectin gene variants to modulate the risk for systemic inflammatory state.
authors.affiliation: Nutrition Department, School of Public Health of University of São Paulo, Brazil.
authors.forename: Marina
authors.initials: M
authors.lastname: Maintinguer Norde
authors.affiliation: Nutrition Department, School of Public Health of University of São Paulo, Brazil.
authors.forename: Érica
authors.initials: É
authors.lastname: Oki
authors.affiliation: Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of São Paulo, Brazil.
authors.forename: Inar Alves
authors.initials: IA
authors.lastname: de Castro
authors.affiliation: Department of Epidemiology, School of Public Health of University of São Paulo, Brazil.
authors.forename: José Maria
authors.initials: JM
authors.lastname: Pacheco Souza
authors.affiliation: Nutrition Department, School of Public Health of University of São Paulo, Brazil.
authors.forename: Nágila Raquel
authors.initials: NR
authors.lastname: Teixeira Damasceno
authors.affiliation: Nutrition Department, School of Public Health of University of São Paulo, Brazil.
authors.forename: Regina
authors.initials: R
authors.lastname: Mara Fisberg
authors.affiliation: Nutrition Department, School of Public Health of University of São Paulo, Brazil.
authors.forename: Dirce Maria
authors.initials: DM
authors.lastname: Lobo Marchioni
authors.affiliation: Nutrition Department, School of Public Health of University of São Paulo, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Macedo Rogero
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D001938:Brazil; D016000:Cluster Analysis; D003430:Cross-Sectional Studies; D005227:Fatty Acids / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000378:metabolism; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D005227:Fatty Acids
keywords: Adiponectin; Plasma fatty acid; Single nucleotide polymorphism; Systemic inflammation