title: Effect of cholestin on toxicity of vitamin A in rats.
abstract: A study was undertaken to investigate the effect of cholestin on the toxicity of vitamin A in male wistar rats. The rats were divided into six groups and fed different diets with or without supplement of 1% cholestin and 25,000-50,000 (IU) vitamin A for 2 months. Hence, the symptoms of vitamin A toxicity in rats included loss of body weight, hepatotoxicity and nephrotoxicity. However, these toxic effects of vitamin A were significantly reduced when the rats fed a diet supplemented with cholestin. Furthermore, the level of vitamin A in the serum of rats treated with cholestin and vitamin A was higher than that of the rats treated with vitamin A alone. It indicated that cholestin might play a role in reducing the toxic effect of vitamin A in rats.
authors.affiliation: School of Health Diet and Industry Management, Chung Shan Medical University, Taichung, Taiwan, ROC; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC. Electronic address: yhyeh@csmu.edu.tw.
authors.forename: Yen-Hung
authors.initials: YH
authors.lastname: Yeh
authors.affiliation: Department of Beauty Science, Chienkuo Technology University, Changhua, Taiwan, ROC.
authors.forename: Ya-Ting
authors.initials: YT
authors.lastname: Lee
authors.affiliation: Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan, ROC.
authors.forename: You-Liang
authors.initials: YL
authors.lastname: Hsieh
mesh_terms: D000818:Animals; D001688:Biological Products / Q000009:adverse effects* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004032:Diet; D019587:Dietary Supplements; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000737:chemistry / Q000633:toxicity*
chemical_list: D001688:Biological Products; C117343:red yeast rice; D014801:Vitamin A
keywords: Cholestin; Hepatotoxicity; Nephrotoxicity; Toxicity; Vitamin A