title: Summary and Future Directions.
abstract: β-barrel outer membrane proteins (OMPs) are found in the outer membranes (OMs) of all gram-negative bacteria, yet exactly how they are folded and inserted remains unknown. The last decade has provided a wealth of discovery including the identification of the BAM complex, a multicomponent complex responsible for the biogenesis of all OMPs into the OM. It is anticipated that the next decade will further advance our knowledge of how the BAM complex is able to perform its unique and interesting function.
authors.affiliation: Department of Biological Sciences Markey Center for Structural Biology, Purdue University, West Lafayette, 47907, IN, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Noinaj
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, 20892, MD, USA. skbuchan@helix.nih.gov.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Buchanan
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism
chemical_list: D001425:Bacterial Outer Membrane Proteins
keywords: BAM complex; BamA; Lateral opening; OMP; Outer membrane protein; Protein folding; β-barrel membrane protein