title: The role of renin-angiotensin aldosterone system related micro-ribonucleic acids in hypertension.
abstract: Micro-ribonucleic acids (miRNAs) are small (21-25 nucleotide) single-stranded, evolutionarily conserved non-protein-coding RNAs, which control diverse cellular functions by interacting with the 3' untranslated region of specific target messenger RNAs at the post-transcriptional level. Research shows that an aberrant expression profile of miRNAs has been linked to a series of diseases, including hypertension. In the past few decades, it has been demonstrated that excessive activation of the renin-angiotensin aldosterone system (RAAS) involves in the pathogenesis of hypertension. This article reviews the latest insights in the identification of RAAS-correlative miRNAs and the potential mechanisms for their roles in hypertension.
authors.affiliation: Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, Hubei Province, Hubei, China. E-mail. 337380615@qq.com.
authors.forename: Hui-Bo
authors.initials: HB
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
mesh_terms: D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000235:genetics*
chemical_list: D035683:MicroRNAs