title: miRNAs: early prognostic biomarkers for Type 2 diabetes mellitus?
abstract: Type 2 diabetes mellitus (T2DM) has reached epidemic proportions and is associated with peripheral insulin resistance. The currently used therapies aim to delay progression of T2DM. Their efficacy could drastically be improved if implemented at earlier stages. Classical diagnostic markers (blood glucose and HbA1C) are generally detected once metabolic imbalance has already set in. Therefore, development of biomarkers for early diagnosis would help identify individuals at risk for developing T2DM. Along with genetic predisposition, epigenetics also plays a major role in T2DM development. In this review, we discuss the potential role of early diagnostic markers such as circulating miRNAs, studies done so far and challenges to be considered while taking into account the novel role of miRNAs as prognostic biomarkers.
authors.affiliation: Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune 411007, India.
authors.forename: Parnika
authors.initials: P
authors.lastname: Bhatia
authors.affiliation: Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune 411007, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Raina
authors.affiliation: Department of Chemistry, Indian Institute of Science Education & Research, Dr. Homi Bhabha Road, Pashan, Pune 411008, India.
authors.forename: Jeetender
authors.initials: J
authors.lastname: Chugh
authors.affiliation: Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune 411007, India.
authors.forename: Shilpy
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000097:blood; D011379:Prognosis
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: HbA1C; Type 2 diabetes mellitus; biomarker; miRNA; pancreatic β-cell