title: CHRNA5 rs16969968 Polymorphism Association with Risk of Lung Cancer--Evidence from 17,962 Lung Cancer Cases and 77,216 Control Subjects.
abstract: BACKGROUND
  Genetic studies have shown a possible relationship between the rs16969968 polymorphism in CHRNA5 and the risk of lung cancer. However, the results have been conflicting. Thus we rigorously conducted a meta-analysis to clarify any association.
  
  
  METHODS
  A total of 10 case-control studies involving 17,962 lung cancer cases and 77,216 control subjects were analysed. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the strength of the association.
  
  
  RESULTS
  We found the CHRNA5 rs16969968 polymorphism to be associated with the risk of lung cancer (AA vs GG: OR=1.60, 95%CI=1.51-1.71). On stratified analysis by smoking status, a statistically significant increased risk was observed in the smoking group (AA vs GG: OR=1.80, 95%CI=1.61-2.01). However, this polymorphism was not associated with lung cancer risk in Asians (AA vs GG: OR=0.95, 95%CI=0.35-2.59), whereas it was linked to increased risk of lung cancer among Caucasians (AA vs GG: OR=1.65, 95%CI=1.55-1.76).
  
  
  CONCLUSIONS
  Our meta-analysis provided statistical evidence for a strong association between rs16969968 polymorphism and the risk of lung cancer, especially in smokers and Caucasians. Application of this relationship may contribute to identification of individuals at high risk of lung cancer and indicate a chemoprevention target.
authors.affiliation: Department of Critical Care Medicine, Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, China E-mail : caocdoctor@163.com, yuhongjinnb@sina.com.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Xu
authors.forename: Guan-Nan
authors.initials: GN
authors.lastname: Wang
authors.forename: Zhou-Zhou
authors.initials: ZZ
authors.lastname: Dong
authors.forename: Tao-Hong
authors.initials: TH
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Cao
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Jin
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011978:Receptors, Nicotinic / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking; D044465:White People / Q000235:genetics*
chemical_list: C447158:CHRNA5 protein, human; D009419:Nerve Tissue Proteins; D011978:Receptors, Nicotinic