title: Chemo-, regio-, and stereo-selective perfluoroalkylations by a Grignard complex with zirconocene.
abstract: The synthesis of highly reactive perfluoroalkyl Grignard reagents with early transition metal zirconocene complexes and their new types of highly chemo-, regio-, and stereo-selective perfluoroalkylation reactions are reported with epoxides in particular. The zirconocene complex is advantageous in activating the perfluoroalkyl Grignard species. The zirconocene·Grignard complexes were clarified by DOSY. Both (1)H and (19)F DOSY analyses show that the addition of MAO and dioxane to the mixture of RFMgCl and Cp2ZrCl2 connects Cp2Zr and RFMg to generate the zirconocene/perfluoroalkyl-Grignard/dioxane complex.
authors.affiliation: Department of Applied Chemistry, Tokyo Institute of Technology, Ookayama 2-12-1, Meguro-ku, Tokyo 152-8552, Japan. mikami.k.ab@m.titech.ac.jp.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Fujiu
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Negishi
authors.forename: Jie
authors.initials: J
authors.lastname: Guang
authors.forename: Paul G
authors.initials: PG
authors.lastname: Williard
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kuroki
authors.forename: Koichi
authors.initials: K
authors.lastname: Mikami