title: Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study.
abstract: The aim of this study was to investigate the efficacy of insulin degludec used for basal-bolus insulin regimen after switching from twice-daily basal insulin in Japanese patients with type 1 diabetes mellitus. The subjects were 22 type 1 diabetes patients treated with basal-bolus insulin regimen with twice-daily basal insulin. Basal insulin was switched to once-daily injection of insulin degludec with 10% dose reduction. HbA1c and fasting plasma glucose (FPG) were measured before and 12 weeks after switching. The frequency of hypoglycemic episodes, standard deviation (SD) of blood glucose, and mean of daily difference (MODD) were evaluated by continuous glucose monitoring (CGM) before and 4 weeks after switching. HbA1c and FPG before and 12 weeks after switching were comparable (HbA1c 8.5 ± 1.4 versus 8.7 ± 1.6%, P = 0.28; FPG 203.2 ± 81.2 versus 206.5 ± 122.4 mg/dL, P = 0.91). The frequency of hypoglycemia during nighttime was not significantly different at 4 weeks after switching (14.4 ± 17.0 versus 11.1 ± 15.0%, P = 0.45). In addition, SD and MODD before and 4 weeks after switching were also comparable. In conclusion, glycemic control under once-daily insulin degludec injection was almost comparable to that under twice-daily basal insulin injections in Japanese type 1 diabetes patients. This study was registered with ID: UMIN000010474.
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Tosaka
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan ; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Kanazawa
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Fuki
authors.initials: F
authors.lastname: Ikeda
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Mayu
authors.initials: M
authors.lastname: Iida
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Sato
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Toyoyoshi
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan ; Sportology Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Tamura
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ogihara
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Mita
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Goto
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Ohmura
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Fujitani
authors.affiliation: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan ; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan ; Sportology Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan ; Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Watada