title: Mitoepigenetics: The different shades of grey.
abstract: Epigenetic modifications of the nuclear genome have been well studied and it is established that these modifications play a key role in nuclear gene expression. However, the status of mitochondrial epigenetic modifications has not been delved in detail. The recent technological advancements in the genome analyzing tools and techniques, have helped in investigating mitochondrial epigenetic modifications with greater resolution and studies have indicated a regulatory role of the mitochondrial epigenome. Association of mitochondrial DNA methylation with various disease conditions, drug treatment, aging, exposure to environmental pollutants etc. has lent credence to this belief. Herein, we have reviewed studies on mitochondrial epigenetic modifications with a focus to comprehend its regulatory role in gene expression and disease association.
authors.affiliation: Genomics and Molecular Medicine, CSIR Institute of Genomics and Integrative Biology (CSIR IGIB), Mathura Road, Delhi, 110 020 Delhi, India; Academy of Scientific and Innovative Research (AcSIR), CSIR IGIB South Campus, Mathura Road, Delhi, 110020 Delhi, India.
authors.forename: Sourav
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Departments of Genetics, Pathology, Environmental Health, University of Alabama at Birmingham, Birmingham, Alabama; Center for Free Radical Biology, Center for Aging and UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama; Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA 35294.
authors.forename: Keshav K
authors.initials: KK
authors.lastname: Singh
authors.affiliation: Genomics and Molecular Medicine, CSIR Institute of Genomics and Integrative Biology (CSIR IGIB), Mathura Road, Delhi, 110 020 Delhi, India; Academy of Scientific and Innovative Research (AcSIR), CSIR IGIB South Campus, Mathura Road, Delhi, 110020 Delhi, India.
authors.forename: Shantanu
authors.initials: S
authors.lastname: Sengupta
authors.affiliation: GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR IGIB), Mathura Road, Delhi, 110 020 Delhi, India; Academy of Scientific and Innovative Research (AcSIR), CSIR IGIB South Campus, Mathura Road, Delhi, 110020 Delhi, India. Electronic address: vinods@igib.in.
authors.forename: Vinod
authors.initials: V
authors.lastname: Scaria
mesh_terms: D000818:Animals; D019175:DNA Methylation; D004272:DNA, Mitochondrial / Q000235:genetics* / Q000378:metabolism*; D044127:Epigenesis, Genetic; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D010944:Plants
chemical_list: D004272:DNA, Mitochondrial
keywords: Epigenetics; Methylation; Mitochondria; Mitochondrial DNA methylation; Mitoepigenetics