title: Sizing up the key determinants of the CD8(+) T cell response.
abstract: Naive CD8(+) T cells give rise to cytotoxic T lymphocytes (CTLs), which promote the effective eradication of viruses and tumours. Although the past decades have seen enormous advances in cellular immunology, a precise understanding of the key elements that determine the specificity and magnitude of primary CTL responses has been lacking. However, recent technological advances have allowed us to more accurately identify, characterize and quantitate key determinants that define the specificity and magnitude of CD8(+) T cell-mediated immunity. This Review discusses the technical and conceptual advances that have markedly changed our understanding of the determinants of primary CTL responses.
authors.affiliation: John Curtin School of Medical Research, The Australian National University, Canberra ACT 0200, Australia.|Research School of Biology, The Australian National University, Canberra ACT 0200, Australia.
authors.forename: David C
authors.initials: DC
authors.lastname: Tscharke
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3141, Australia.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Croft
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.|Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38103, USA.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Doherty
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: La Gruta
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002465:Cell Movement; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D007156:Immunologic Memory; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D011948:Receptors, Antigen, T-Cell