title: Periprocedural plasma fibrinogen levels and coronary stent outcome.
abstract: OBJECTIVE
  Percutaneous intervention is one of the treatment option for coronary artery disease. Reinfarction and restenosis is one of the complication of the procedure. So this study was conducted to assess plasma fibrinogen levels pre- and post coronary stenting and its relation with outcome.
  
  
  METHODS
  After obtaining informed consent, venous blood samples were collected at three timed points in relation to stenting - 24h before, 24h after and 72h after stenting to assess fibrinogen levels. Patients were followed up for six months. Repeat revascularization, myocardial infarction and symptomatic angina were considered as major adverse clinical events.
  
  
  RESULTS
  57 patients who underwent successful stenting and followed up for six months up were included in the study. Mean age was 53 years and 87.7% were males and 29.8% were diabetics. Baseline plasma fibrinogen level was significantly high in patients who developed repeat angina and myocardial infarction after the stenting [288.64±59.43 vs 393.75±32.97mg/dL, p=0.003] and it remained high during serial assessment [322.74±63.92 vs 422.00±55.28mg/dL, 326.23±65.81 vs 419.50±45.82mg/dL, 0.008, 0.012 respectively]. Patients who developed adverse events denied any drug default.
  
  
  CONCLUSIONS
  We conclude that plasma fibrinogen plays a significant role in the development of adverse events following stenting shown by high level of plasma fibrinogen in patients who developed adverse events.
authors.affiliation: Department of Biochemistry, PSGIMSR, Tamil Nadu, India. Electronic address: kavie2001@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Kavitha
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry, India.
authors.forename: M G
authors.initials: MG
authors.lastname: Sridhar
authors.affiliation: Department of Cardiology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry, India.
authors.forename: S
authors.initials: S
authors.lastname: Satheesh
mesh_terms: D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D017558:Elective Surgical Procedures; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011183:Postoperative Complications / Q000097:blood* / Q000453:epidemiology; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D005340:Fibrinogen
keywords: Cardiovascular disease; Coronary stenting; Fibrinogen; Reinfarction; Stent outcome