title: CHIKUNGUNYA-ASSOCIATED UVEITIS AND EXUDATIVE RETINAL DETACHMENT: A CASE REPORT.
abstract: OBJECTIVE
  To report the first known case of bilateral granulomatous panuveitis secondary to chikungunya fever in the United States, acquired by a U.S. citizen traveling from an endemic region.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 47-year-old woman presented with 10 days of bilateral decreased vision and photophobia concurrent with a febrile illness contracted while visiting the Dominican Republic. She presented with bilateral granulomatous panuveitis and exudative retinal detachments. Extensive workup was negative with the exception of positive chikungunya virus immunoglobulin G and immunoglobulin M titers. Initially, she responded to corticosteroid treatment but developed recurrent inflammation 3 months after completing the initial treatment. Immunomodulatory therapy was initiated at the time of recurrence, and with immunomodulatory therapy alone her inflammation has been controlled for 6 months.
  
  
  CONCLUSIONS
  The prevalence of chikungunya fever-related uveitis is increasing with the recent epidemics throughout the Americas. Inflammation can occur during the febrile illness or months later and can manifest in a variety of ways. Posterior segment inflammation is more commonly a delayed presentation. Previous reports suggest that chikungunya fever-related uveitis responds well to corticosteroid therapy. This is the first reported case of recurrent inflammation. Given the wide variety of presentations, chikungunya fever-related uveitis should be included in the differential diagnosis of all at-risk patients presenting with acute ocular inflammation, particularly those traveling from endemic regions.
authors.affiliation: *Department of Ophthalmology, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York; and †Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Nicole K
authors.initials: NK
authors.lastname: Scripsema
authors.forename: Emile
authors.initials: E
authors.lastname: Sharifi
authors.forename: C Michael
authors.initials: CM
authors.lastname: Samson
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kedhar
authors.forename: Richard B
authors.initials: RB
authors.lastname: Rosen
mesh_terms: D065632:Chikungunya Fever / Q000150:complications*; D005122:Exudates and Transudates; D005260:Female; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D015864:Panuveitis / Q000209:etiology*; D012163:Retinal Detachment / Q000209:etiology*