title: Metabonomic Study of Biochemical Changes in Human Hair of Heroin Abusers by Liquid Chromatography Coupled with Ion Trap-Time of Flight Mass Spectrometry.
abstract: Hair analysis is with the advantage of non-invasive collection and long surveillance window. The present study employed a sensitive and reliable liquid chromatography coupled with ion trap-time of flight mass spectrometry method to study the metabonomic characters in the hair of 58 heroin abusers and 72 non-heroin abusers. Results indicated that certain endogenous metabolites, such as sorbitol and cortisol, were accelerated, and the level of arachidonic acid, glutathione, linoleic acid, and myristic acid was decreased in hair of heroin abusers. The metabonomic study is helpful for further understanding of heroin addiction and clinical diagnosis.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, People's Republic of China.|Shenzhen Institute for Drug Control, Shenzhen, 518057, People's Republic of China.
authors.forename: Pu
authors.initials: P
authors.lastname: Xie
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen, 518057, People's Republic of China.
authors.forename: Tie-jie
authors.initials: TJ
authors.lastname: Wang
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen, 518057, People's Republic of China.
authors.forename: Guo
authors.initials: G
authors.lastname: Yin
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen, 518057, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen, 518057, People's Republic of China.
authors.forename: Li-he
authors.initials: LH
authors.lastname: Xiao
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, People's Republic of China. kaishunbi.syphu@gmail.com.
authors.forename: Kai-shun
authors.initials: KS
authors.lastname: Bi
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D005978:Glutathione / Q000032:analysis; D006197:Hair / Q000737:chemistry / Q000378:metabolism*; D006556:Heroin Dependence / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D019787:Linoleic Acid / Q000032:analysis; D008297:Male; D055442:Metabolome; D008875:Middle Aged; D019814:Myristic Acid / Q000032:analysis; D013012:Sorbitol / Q000032:analysis; D015813:Substance Abuse Detection / Q000379:methods
chemical_list: D019814:Myristic Acid; D016718:Arachidonic Acid; D013012:Sorbitol; D019787:Linoleic Acid; D005978:Glutathione; D006854:Hydrocortisone
keywords: Heroin abusers; Human hair; Ion trap-TOF-MS; Metabonomics