title: Reduced occurrence of ventilator-associated pneumonia after cardiac surgery using preoperative 0.2% chlorhexidine oral rinse: results from a single-centre single-blinded randomized trial.
abstract: Since mechanical ventilation after cardiac surgery increases the risk of ventilator-associated pneumonia (VAP), we conducted a prospective randomized controlled trial to investigate the effect of preoperative 0.2% chlorhexidine on postoperative VAP. Ninety-four patients scheduled for heart surgery were randomized to a chlorhexidine group (N = 47) or control (saline) group (N = 47). On the day before surgery, patients gargled three times with 0.2% chlorhexidine or saline 30 min after each meal and 5 min after teeth brushing at bedtime. VAP occurred in 8.5% of the chlorhexidine group and in 23.4% of the controls. Preoperative chlorhexidine mouthwash reduced the incidence of postoperative VAP significantly.
authors.affiliation: Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China. Electronic address: fjxhlyj@163.com.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: X Z
authors.initials: XZ
authors.lastname: Huang
authors.affiliation: Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: F
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: S L
authors.initials: SL
authors.lastname: Li
authors.affiliation: Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: F
authors.initials: F
authors.lastname: Lin
authors.affiliation: Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Ye
authors.affiliation: Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: M L
authors.initials: ML
authors.lastname: Chen
authors.affiliation: Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002710:Chlorhexidine / Q000627:therapeutic use*; D004202:Disinfectants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology* / Q000517:prevention & control*; D011446:Prospective Studies; D016037:Single-Blind Method; D013903:Thoracic Surgery; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004202:Disinfectants; D009067:Mouthwashes; D002710:Chlorhexidine
keywords: Cardiac surgery; Chlorhexidine; Prophylaxis; Ventilator-associated pneumonia