title: Effect of Royal Jelly on new bone formation in rapid maxillary expansion in rats.
abstract: BACKGROUND
  The aim of this study was to evaluate the effects of long and short term systemic usage of royal jelly on bone formation in the expanded maxillary suture in a rat model.
  
  
  METHODS
  Twenty eight Wistar albino rats were randomly divided into 4 equal groups: Control (C); Only Expansion (OE), Royal Jelly (RJ) group, Royal Jelly was given to rats by oral gavage only during the expansion and retention period; Royal Jelly plus Nursery (RJN) group, Royal Jelly was given to rats by oral gavage during their nursery phase of 40 days and during the retention period. After the 5 day expansion period was completed, the rats underwent 12 days of mechanical retention. All rats were sacrificed in same time. Histological examination was performed to determine the number of osteoclasts, number of osteoblasts, number of capillaries, inflammatory cell infiltration, and new bone formation.
  
  
  RESULTS
  New bone formation, number of osteoclasts, number of osteoblasts, and the number of capillaries in the expanded maxillary sutures were higher in the RJ and RJN groups than in the other groups. Statistical analysis also demonstrated that new bone formation and the number of osteoblasts was also highest in the RJN group.
  
  
  CONCLUSIONS
  The systemic administration of Royal Jelly in conjunction with rapid maxillary expansion may increase the quality of regenerated bone.
authors.affiliation: Abant Izzet Baysal University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery Bolu, Turkey, toptasorcun@yahoo.com.
authors.forename: Fatih
authors.initials: F
authors.lastname: Özan
authors.forename: Bayram
authors.initials: B
authors.lastname: Çörekçi
authors.forename: Orçun
authors.initials: O
authors.lastname: Toptaş
authors.forename: Koray
authors.initials: K
authors.lastname: Halicioğlu
authors.forename: Celal
authors.initials: C
authors.lastname: Irgin
authors.forename: Fahri
authors.initials: F
authors.lastname: Yilmaz
authors.forename: Yasin
authors.initials: Y
authors.lastname: Hezenci
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000494:pharmacology*; D007301:Insect Hormones / Q000494:pharmacology*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D010155:Palatal Expansion Technique; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D000099219:Royal Jelly
chemical_list: D005227:Fatty Acids; D007301:Insect Hormones; D000099219:Royal Jelly