title: Individual and Joint Associations of Methylenetetrahydrofolate Reductase C677T Genotype and Plasma Homocysteine With Dyslipidemia in a Chinese Population With Hypertension.
abstract: We aimed to examine the cross-sectional associations of plasma total homocysteine (tHcy) concentrations and methylenetetrahydrofolate reductase ( MTHFR) C677T genotype with dyslipidemia. A total of 231 patients with mild-to-moderate essential hypertension were enrolled from the Huoqiu and Yuexi communities in Anhui Province, China. Plasma tHcy levels were measured by high-performance liquid chromatography. Genotyping was performed by TaqMan allelic discrimination technique. Compared with MTHFR 677 CC + CT genotype carriers, TT genotype carriers had higher odds of hypercholesterolemia (adjusted odds ratio [OR] [95% confidence interval (CI)]: 2.7 [1.4-5.2]; P = .004) and higher odds of abnormal low-density lipoprotein cholesterol (adjusted OR [95% CI]: 2.3 [1.1-4.8]; P = .030). The individuals with the TT genotype had higher concentrations of log(tHcy) than those with the 677 CC + CT genotype (adjusted β [standard error]: .2 [0.03]; P < .001). Patients with tHcy ≥ 10 μmol/L had significantly higher odds of hypercholesterolemia (adjusted OR [95% CI]: 2.4 [1.2-4.7]; P = .010). Furthermore, patients with both the TT genotype and the tHcy ≥ 10 μmol/L had the highest odds of hypercholesterolemia (adjusted OR [95% CI]: 4.1 [1.8-9.4]; P = .001) and low-density lipoprotein cholesterol (adjusted OR [95% CI]: 2.4 [1.0-6.0]; P = .064). This study suggests that both tHcy and the MTHFR C677T gene polymorphism may be important determinants of the incidence of dyslipidemia in Chinese patients with essential hypertension. Further studies are needed to confirm the role of tHcy and the MTHFR C677T mutation in the development of dyslipidemia in a larger sample.
authors.affiliation: 1 School of Life Sciences, Anhui University, Hefei, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 1 School of Life Sciences, Anhui University, Hefei, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Li
authors.affiliation: 2 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Venners
authors.affiliation: 3 HSL, Institute for Aging Research, Harvard Medical School, Boston, MA, USA.|4 Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Yi-Hsiang
authors.initials: YH
authors.lastname: Hsu
authors.affiliation: 1 School of Life Sciences, Anhui University, Hefei, China.|5 Institute of Biomedicine, Anhui Medical University, Hefei, China.
authors.forename: Shanqun
authors.initials: S
authors.lastname: Jiang
authors.affiliation: 6 Department of Statistics, University of Virginia, Charlottesville, VA, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Weinstock
authors.affiliation: 5 Institute of Biomedicine, Anhui Medical University, Hefei, China.
authors.forename: Binyan
authors.initials: B
authors.lastname: Wang
authors.affiliation: 5 Institute of Biomedicine, Anhui Medical University, Hefei, China.
authors.forename: Genfu
authors.initials: G
authors.lastname: Tang
authors.affiliation: 5 Institute of Biomedicine, Anhui Medical University, Hefei, China.|7 Division of Epidemiology and Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, IL, USA.
authors.forename: Xiping
authors.initials: X
authors.lastname: Xu
mesh_terms: D044466:Asian People; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000209:etiology*; D000075222:Essential Hypertension; D005838:Genotype; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood; D006973:Hypertension / Q000097:blood*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*
chemical_list: D008078:Cholesterol, LDL; D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: MTHFR C677T; dyslipidemia; hyperhomocysteinemia; polymorphism