title: Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles.
abstract: We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6-20 times more selective than the parent drugs.
authors.affiliation: Department of Bioengineering, Beckman Institute for Advanced Science and Technology, Materials Science and Engineering, Carle Foundation Hospital, University of Illinois at Urbana-Champaign, and Carle Foundation Hospital, 502 N. Busey, Urbana, USA. dipanjan@illinois.edu.
authors.forename: S K
authors.initials: SK
authors.lastname: Misra
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: I
authors.initials: I
authors.lastname: Srivastava
authors.forename: M K
authors.initials: MK
authors.lastname: Imgruet
authors.forename: R W
authors.initials: RW
authors.lastname: Graff
authors.forename: A
authors.initials: A
authors.lastname: Ohoka
authors.forename: T L
authors.initials: TL
authors.lastname: Kampert
authors.forename: H
authors.initials: H
authors.lastname: Gao
authors.forename: D
authors.initials: D
authors.lastname: Pan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship; D064726:Triple Negative Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D011108:Polymers; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D004250:DNA Topoisomerases, Type II