title: l-Scoulerine attenuates behavioural changes induced by methamphetamine in zebrafish and mice.
abstract: Methamphetamine (METH), a substance with a high potential for abuse and addiction, is a serious worldwide public health problem. METH addicts often show extreme paranoia, anxiety, and depression. Thus, there is no effective medication for the treatment of METH-induced abnormalities. In the present study, we investigated the effects of l-Scoulerine (l-SLR), a tetrahydroprotoberberine (THPBS) alkaloid, on METH-induced anxiety-like behaviour in zebrafish and METH-induced addictive behavior in mice. In the novel tank test, acute administration of METH (2 mg/L) induced a significant decrease in the number of total vertical transitions and time spent in the upper zone. Moreover, METH produced significant avoidance behaviour showing increased swimming time in the central area and high speed movement in the mirror area in the mirror stimulation test; these anxiety-like changes were attenuated by l-SLR. Chronic administration of METH (2 mg/kg) produced a steady increase in locomotor activity and conditioned place preference in mice. l-SLR (5 mg/kg) failed to reduce acute METH-induced hyperlocomotion, but attenuated chronic METH-induced behavioural sensitization and significantly blocked the expression of conditioned place preference induced by METH in mice. The present study suggests that l-SLR may be a promising agent for the treatment of addiction and anxiety induced by METH.
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Guiyun
authors.initials: G
authors.lastname: Mi
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Jin
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Enmao
authors.initials: E
authors.lastname: Ye
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Liu
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
authors.forename: Zehui
authors.initials: Z
authors.lastname: Gong
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing 100850, China. Electronic address: yanghongju618@sina.com.
authors.forename: Hongju
authors.initials: H
authors.lastname: Yang
authors.affiliation: Beijing Institute of Basic Medical Sciences, Beijing 100850, China. Electronic address: yangzhengchina@aliyun.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
mesh_terms: D019969:Amphetamine-Related Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D000818:Animals; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000503:physiopathology; D001600:Berberine Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D002491:Central Nervous System Agents / Q000737:chemistry / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011897:Random Allocation; D013037:Spatial Behavior / Q000187:drug effects; D015027:Zebrafish
chemical_list: D001600:Berberine Alkaloids; D002491:Central Nervous System Agents; D000697:Central Nervous System Stimulants; D008694:Methamphetamine; C010941:discretamine
keywords: Conditioned place preference; Methamphetamine; Sensitization; Zebrafish