title: Implications of dietary salt intake for multiple sclerosis pathogenesis.
abstract: In recent years it has become increasingly clear that, alongside genetic risk factors, environmental factors strongly influence the incidence and severity of multiple sclerosis (MS). Based on observations from epidemiological studies, the potential contribution of dietary habits has lately been a matter of debate. Recently it was shown that high salt conditions promote pathogenic T-cell responses and aggravate autoimmunity in an animal model of MS, suggesting that high dietary salt intake might promote central nervous system (CNS) autoimmunity. However, so far, not much is known about the influence of dietary salt intake on MS disease pathology. Here, we discuss the association of dietary salt levels and MS with a special focus on the mechanisms of salt-mediated modulation of the different cell types critically involved in the pathophysiology of MS.
authors.affiliation: University of Muenster, Department of Neurology, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Hucke
authors.affiliation: University of Muenster, Department of Neurology, Germany.
authors.forename: Heinz
authors.initials: H
authors.lastname: Wiendl
authors.affiliation: University of Muenster, Department of Neurology, Germany luisa.klotz@ukmuenster.de.
authors.forename: Luisa
authors.initials: L
authors.lastname: Klotz
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D004032:Diet / Q000706:statistics & numerical data; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D042783:Endothelial Cells / Q000276:immunology*; D004847:Epithelial Cells / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D064307:Microbiota / Q000276:immunology*; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology; D012307:Risk Factors; D017673:Sodium Chloride, Dietary / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D017673:Sodium Chloride, Dietary
keywords: Immunology; T cells; dietary salt intake; environmental factors; macrophages; multiple sclerosis