title: Parallel Parkin: Cdc20 Takes a New Partner.
abstract: CDC20 and CDH1 are well-established substrate receptors for the Anaphase Promoting Complex/Cyclosome (APC/C). In this issue of Molecular Cell, Lee et al. (2015) show that these adaptors can also target cell cycle proteins for destruction through a second ubiquitin ligase, Parkin.
authors.affiliation: Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Fernando
authors.initials: F
authors.lastname: Meza-Gutierrez
authors.affiliation: Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Frances V
authors.initials: FV
authors.lastname: Hundley
authors.affiliation: Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: dpt4darwin@gmail.com.
authors.forename: David P
authors.initials: DP
authors.lastname: Toczyski
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D064199:Cdc20 Proteins / Q000378:metabolism*; D042822:Genomic Instability; D006801:Humans; D008938:Mitosis; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D015820:Cadherins; D064199:Cdc20 Proteins; D044767:Ubiquitin-Protein Ligases