title: Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus.
abstract: We report two cases of brain metastasis in patients initially diagnosed with extremely early stage UPSC after extensive staging surgery. They did not receive either adjuvant chemotherapy or adjuvant pelvic or vaginal cuff radiation. At the same time that these patients were diagnosed with systemic metastasis, they both had a local "drop" metastasis in the vulva or the vaginal cuff. After the initial response to palliative chemotherapy, they both developed brain metastasis. The pattern of recurrence with the lack of adjuvant treatment underscores the urgent need in further evaluation of the potential benefits of adjuvant treatment, including chemotherapy and possibly in combination with radiation in this highly aggressive disease.
authors.affiliation: Department of Obstetrics and Gynecology, Maimonides Medical Center, United States.
authors.forename: Deepa M
authors.initials: DM
authors.lastname: Narasimhulu
authors.affiliation: Department of Obstetrics and Gynecology, Maimonides Medical Center, United States.
authors.forename: Neekianund
authors.initials: N
authors.lastname: Khulpateea
authors.affiliation: Department of Radiation Oncology, Maimonides Medical Center, United States.
authors.forename: Keith
authors.initials: K
authors.lastname: Meritz
authors.affiliation: Division of Hematology and oncology, Maimonides Medical Center, United States.
authors.forename: Yiquing
authors.initials: Y
authors.lastname: Xu
keywords: Adjuvant chemotherapy; Brain metastasis; Papillary serous carcinoma of the uterus; Pelvic radiation; Vaginal cuff radiation