title: Sleep Apnea Research in Animals. Past, Present, and Future.
abstract: Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of the upper airway during sleep. Animal models have been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animals with spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.
authors.affiliation: Division of Pulmonary and Critical Care Medicine Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Swati
authors.initials: S
authors.lastname: Chopra
authors.affiliation: Division of Pulmonary and Critical Care Medicine Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Vsevolod Y
authors.initials: VY
authors.lastname: Polotsky
authors.affiliation: Division of Pulmonary and Critical Care Medicine Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Jun
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000266:history / Q000639:trends; D004059:Diffusion of Innovation; D004195:Disease Models, Animal; D005544:Forecasting; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology*; D011379:Prognosis; D012119:Respiration; D012890:Sleep; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000209:etiology / Q000266:history / Q000503:physiopathology* / Q000628:therapy; D013045:Species Specificity
keywords: animal; fragmentation; intermittent hypoxia; sleep apnea