title: Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses.
abstract: How does the body's immune system strike the delicate balance between under- and over-response? A new study shows that glucocorticoids limit the production of the proinflammatory cytokine interleukin-12 by dendritic cells in response to invading bacteria, thereby helping to avoid sepsis. Read the Research Article.
authors.affiliation: Freelance Science Writer, Sherborn, Massachusetts, United States of America.
authors.forename: Richard
authors.initials: R
authors.lastname: Robinson
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D057134:Antibodies, Neutralizing / Q000627:therapeutic use*; D003713:Dendritic Cells / Q000187:drug effects*; D005260:Female; D005938:Glucocorticoids / Q000819:agonists*; D018664:Interleukin-12 / Q000037:antagonists & inhibitors*; D008297:Male; D011965:Receptors, Glucocorticoid / Q000819:agonists*; D012772:Shock, Septic / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D057134:Antibodies, Neutralizing; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D018664:Interleukin-12