title: Giving Time Purpose: The Synechococcus elongatus Clock in a Broader Network Context.
abstract: Early research on the cyanobacterial clock focused on characterizing the genes needed to keep, entrain, and convey time within the cell. As the scope of assays used in molecular genetics has expanded to capture systems-level properties (e.g., RNA-seq, ChIP-seq, metabolomics, high-throughput screening of genetic variants), so has our understanding of how the clock fits within and influences a broader cellular context. Here we review the work that has established a global perspective of the clock, with a focus on (a) an emerging network-centric view of clock architecture, (b) mechanistic insights into how temporal and environmental cues are transmitted and integrated within this network,
authors.affiliation: Center for Circadian Biology, University of California San Diego, La Jolla, USA, 92093.|Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, USA, 92093.
authors.forename: Ryan K
authors.initials: RK
authors.lastname: Shultzaberger
authors.affiliation: Center for Circadian Biology, University of California San Diego, La Jolla, USA, 92093.|Division of Biological Sciences, University of California San Diego, La Jolla, USA, 92093.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Boyd
authors.affiliation: Center for Circadian Biology, University of California San Diego, La Jolla, USA, 92093.|Division of Biological Sciences, University of California San Diego, La Jolla, USA, 92093.
authors.forename: Spencer
authors.initials: S
authors.lastname: Diamond
authors.affiliation: Center for Circadian Biology, University of California San Diego, La Jolla, USA, 92093.|Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, USA, 92093.
authors.forename: Ralph J
authors.initials: RJ
authors.lastname: Greenspan
authors.affiliation: Center for Circadian Biology, University of California San Diego, La Jolla, USA, 92093.|Division of Biological Sciences, University of California San Diego, La Jolla, USA, 92093.
authors.forename: Susan S
authors.initials: SS
authors.lastname: Golden
mesh_terms: D000220:Adaptation, Biological; D005075:Biological Evolution; D002940:Circadian Rhythm / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D015398:Signal Transduction; D046940:Synechococcus / Q000166:cytology / Q000502:physiology*
keywords: RpaA; circadian rhythms; global regulation; kai oscillator