title: A lncRNA to repair DNA.
abstract: Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al [1] identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al [1] thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.
authors.affiliation: NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jiri
authors.initials: J
authors.lastname: Lukas
authors.affiliation: IVBMB, University of Zurich, Zurich, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Altmeyer
mesh_terms: D019313:BRCA1 Protein / Q000378:metabolism*; D004249:DNA Damage; D059765:Homologous Recombination; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism*
chemical_list: D019313:BRCA1 Protein; D062085:RNA, Long Noncoding