title: Successful treatment with intravenous high-dose immunoglobulin for cardiomyopathy in dermatomyositis complicated with rapid progressive interstitial pneumonia.
abstract: Cardiomyopathy and rapid progressive interstitial pneumonia (IP) are potentially fatal complications in polymyositis/dermatomyositis. We experienced a dermatomyositis patient with multiple adverse prognostic factors, complicating rapid progressive IP, macrophage activation syndrome (MAS), and cardiomyopathy. IP and MAS improved with strong immunosuppressive therapy, despite which cardiomyopathy developed. Therefore, we applied intravenous high-dose immunoglobulin therapy (IVIg), and cardiac function improved dramatically. This is the first report to present the effectiveness of IVIg for cardiomyopathy in dermatomyositis.
authors.affiliation: Department of Respiratory Medicine, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yoshimatsu
authors.affiliation: Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kotani
authors.affiliation: Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
authors.forename: Youhei
authors.initials: Y
authors.lastname: Fujiki
authors.affiliation: Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Oda
authors.affiliation: Department of Cardiology, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Kataoka
authors.affiliation: Department of Respiratory Medicine, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Yamairi
authors.affiliation: Department of Rheumatology, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Hata
authors.affiliation: Department of Respiratory Medicine, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Otani
authors.affiliation: Department of Respiratory Medicine, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Kamimori
authors.affiliation: Department of Respiratory Medicine, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujiwara
mesh_terms: D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D003882:Dermatomyositis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D018450:Disease Progression; D004452:Echocardiography; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000276:immunology; D055501:Macrophage Activation Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D007166:Immunosuppressive Agents
keywords: clinical aspects (myositis and related syndromes); drug treatment (myositis and related syndromes); myositis and related syndromes