title: Drug-induced hypersensitivity syndrome by liposomal amphotericin-B: a case report.
abstract: BACKGROUND
  Liposomal amphotericin-B (Ambisome(®)) is widely used antifungal drug for treatments of invasive fungal infections. The use of liposomal amphotericin-B is increasing in medical setting because of its tolerability and potent antifungal activity.
  
  
  METHODS
  In a case of a 76 year-old Japanese female was admitted with subarachnoid hemorrhage, the ethnicity of the patient is Asian, we experienced that liposomal amphotericin-B was the culprit drug for Drug-induced hypersensitivity syndrome, also known as drug rash with eosinophilia and systemic symptoms in view of a clear temporal relationship between liposomal amphotericin-B administration and the onset of symptoms, the remission of the symptomatological pattern after liposomal amphotericin-B withdrawal.
  
  
  CONCLUSIONS
  The present case report shows that prolonged liposomal amphotericin-B treatment can be associated with drug rash with eosinophilia and systemic symptoms. We recommend careful monitoring of neutrophil counts in a prolonged treatment course with liposomal amphotericin-B.
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. hagimao@aichi-med-u.ac.jp.|Department of Pharmacy, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan. hagimao@aichi-med-u.ac.jp.
authors.forename: Mao
authors.initials: M
authors.lastname: Hagihara
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. y.yamagishi@mac.com.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yamagishi
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. hirai.jun.326@mail.aichi-med-u.ac.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Hirai
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. koizumi.yuusuke.846@mail.aichi-med-u.ac.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Koizumi
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. hideok@aichi-med-u.ac.jp.|Department of Pharmacy, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan. hideok@aichi-med-u.ac.jp.
authors.forename: Hideo
authors.initials: H
authors.lastname: Kato
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. hamayuki@aichi-med-u.ac.jp.|Department of Pharmacy, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan. hamayuki@aichi-med-u.ac.jp.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Hamada
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. matu3911@aichi-med-u.ac.jp.|Department of Pharmacy, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan. matu3911@aichi-med-u.ac.jp.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Matsuura
authors.affiliation: Department of Infection Control and Prevention, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. mikamo@aichi-med-u.ac.jp.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001132:Arm / Q000473:pathology; D004342:Drug Hypersensitivity / Q000188:drug therapy*; D005260:Female; D006801:Humans; D013577:Syndrome
chemical_list: D000900:Anti-Bacterial Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B