title: Antibody profile in Indian severe haemophilia A patients with and without FVIII inhibitors.
abstract: Diagnosis and management of haemophilia patients with inhibitors is often tricky due to the heterogeneous nature of the antibodies with regard to their kinetics, as well as the co-existence of other interfering antibodies. Plasma samples from severe haemophilia A patients from India with and without FVIII inhibitors were analysed for the presence of possible co-existing antibodies such as lupus anticoagulants (LA), anti-cardiolipin antibodies (ACLA), anti-β2-glycoprotein-I (anti-β2-GP-I) antibodies, viral transfusion transmitted disease (HIV, HBsAg, HCV) related antibodies, anti-cyclic citrullinated peptides (anti-CCP), and anti-nuclear antibodies. A high incidence of LA and anti-HCV antibodies was detected in Indian haemophilia A patients similar to earlier reports. More importantly, a relatively high incidence of autoantibodies to nuclear antigens (18.62%) and anti-CCP antibodies (1.38%) associated with autoimmune disorders was also seen in these congenital haemophilia A patients with and without inhibitors. Knowledge on the antibody profile in these haemophilia patients especially in those with FVIII inhibitors along with correlation with the clinical manifestations and other risk factors for inhibitor development could possibly shed more light on the complex immune response in these patients.
authors.affiliation: National Institute of Immunohaematology (ICMR), 13th Floor, New Multistoreyed Building, KEM Hospital Campus, Parel, Mumbai 400012, India.
authors.forename: Patricia
authors.initials: P
authors.lastname: Pinto
authors.affiliation: National Institute of Immunohaematology (ICMR), 13th Floor, New Multistoreyed Building, KEM Hospital Campus, Parel, Mumbai 400012, India.
authors.forename: Shrimati
authors.initials: S
authors.lastname: Shetty
authors.affiliation: INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie-Paris 6, UMRS 1138, Paris, France; Université Paris Descartes, UMRS 1138, Paris, France; Laboratoire International Associé INSERM (France) - ICMR, India.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Lacroix-Desmazes
authors.affiliation: INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie-Paris 6, UMRS 1138, Paris, France; Université Paris Descartes, UMRS 1138, Paris, France; Laboratoire International Associé INSERM (France) - ICMR, India.
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
authors.affiliation: INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie-Paris 6, UMRS 1138, Paris, France; Université Paris Descartes, UMRS 1138, Paris, France; Laboratoire International Associé INSERM (France) - ICMR, India.
authors.forename: Srini
authors.initials: S
authors.lastname: Kaveri
authors.affiliation: National Institute of Immunohaematology (ICMR), 13th Floor, New Multistoreyed Building, KEM Hospital Campus, Parel, Mumbai 400012, India. Electronic address: kanjakshaghosh@hotmail.com.
authors.forename: Kanjaksha
authors.initials: K
authors.lastname: Ghosh
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D005169:Factor VIII / Q000276:immunology; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D056724:Immunity, Humoral; D007167:Immunotherapy; D007194:India; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D014777:Virus Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D007518:Isoantibodies; C078147:F8 protein, human; D005169:Factor VIII
keywords: Autoantibodies; FVIII; Haemophilia A; India; Inhibitors