title: Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities.
abstract: This study sought to investigate the anticholinesterase and antioxidative properties of quercetin and its glycosylated conjugate, rutin. The in vitro inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities, inhibition of Fe(2+)-induced lipid peroxidation in rat's brain homogenates, radicals scavenging, and Fe(2+)-chelating abilities of the flavonoids were investigated in vitro with concentrations of the samples ranging from 0.06 to 0.6 mM. Quercetin had significantly higher AChE and BChE inhibitory abilities than rutin. Quercetin also had stronger inhibition of Fe(2+)-induced lipid peroxidation in rat's brain homogenates. Similarly, quercetin had higher radical scavenging abilities than rutin. Quercetin also had stronger Fe(2+)-chelating ability than rutin. The inhibition of cholinesterases and antioxidative properties are possible mechanisms by which the flavonoids can be used in the management of oxidative stress-induced neurodegeneration.
authors.affiliation: Federal University of Technology, Akure, Nigeria.
authors.forename: Ayokunle O
authors.initials: AO
authors.lastname: Ademosun
authors.affiliation: Federal University of Technology, Akure, Nigeria goboh2001@yahoo.com.
authors.forename: Ganiyu
authors.initials: G
authors.lastname: Oboh
authors.affiliation: Federal University of Technology, Akure, Nigeria.
authors.forename: Fatai
authors.initials: F
authors.lastname: Bello
authors.affiliation: Federal University of Technology, Akure, Nigeria.
authors.forename: Peluola O
authors.initials: PO
authors.lastname: Ayeni
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D002091:Butyrylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D012431:Rutin / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D012431:Rutin; D011794:Quercetin; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase
keywords: Alzheimer’s disease; acetylcholinesterase; antioxidant; butyrylcholinesterase