title: Occupational Exposure to Veterinary Workers from the Positron Emission Tomography Imaging Agent 64Cu-ATSM.
abstract: Cu-ATSM is an emerging radiopharmaceutical for diagnostic use in positron emission tomography (PET), but to date there are no studies that assess the potential occupational doses to workers in either human or veterinary medicine. This study was aimed at determining the external radiation dose to veterinary workers from clinical PET/CT (PET combined with computed tomography) procedures using Cu-ATSM. To determine the dose to the workers, each worker was assigned two Electronic Personal Dosimeters (EPDs) to be worn on the chest and waist during the entirety of each procedure. The workers monitored during this study included a radiobiologist, a nuclear medicine technologist, an anesthesiologist, and a veterinary surgeon. Seven canine patients were imaged with an average mass of 33.7 kg (a range of 20.0-55.1 kg) with an average injected activity of 5 MBq kg. The dose range for the radiobiologist was 2-17 μSv (mean of 7.1 μSv), for the nuclear medicine technologist 0-14 μSv (mean of 5.6 μSv), for the anesthesiologist 0-12 μSv (mean of 4.0 μSv), and for the surgeon 0-10 μSv (mean of 3.6 μSv). In a comparison between the results of this study and published literature on occupational exposures from veterinary FDG PET/CT procedures, Cu-ATSM veterinary PET/CT procedures, on a per patient bias, exposed workers to less radiation.
authors.affiliation: *Colorado State University, Department of Environment and Radiological Health Sciences, Fort Collins, Co.
authors.forename: Lucas D
authors.initials: LD
authors.lastname: Hetrick
authors.forename: Susan L
authors.initials: SL
authors.lastname: Kraft
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Johnson
mesh_terms: D000818:Animals; D056831:Coordination Complexes; D003301:Copper Radioisotopes / Q000009:adverse effects*; D004285:Dogs; D006801:Humans; D016273:Occupational Exposure; D009942:Organometallic Compounds / Q000032:analysis*; D049268:Positron-Emission Tomography / Q000009:adverse effects* / Q000379:methods*; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods; D011874:Radiometry / Q000295:instrumentation / Q000379:methods*; D019275:Radiopharmaceuticals / Q000009:adverse effects*; D013882:Thiosemicarbazones / Q000032:analysis*; D014730:Veterinary Medicine / Q000379:methods*
chemical_list: D056831:Coordination Complexes; D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013882:Thiosemicarbazones; C089548:copper (II) diacetyl-di(N(4)-methylthiosemicarbazone)