title: The Role of Systemic Retinoids in the Treatment of Cutaneous T-Cell Lymphoma.
abstract: Retinoids are natural and synthetic vitamin A analogs with effects on cell proliferation, differentiation, and apoptosis. They have significant activity in hematologic malignancies and have been studied extensively in cutaneous T-cell lymphoma. Retinoids bind to nuclear receptors and exert their effects through moderation of gene expression. Retinoic acid receptor and retinoic X receptor exert regulatory activity in vivo, binding to distinct ligands. Studies investigating systemic retinoids as monotherapy and in combination with other agents active against cutaneous lymphoma are reviewed. Side effects associated with retinoids include teratogenicity, dyslipidemias, and hypothyroidism, which should be carefully monitored in patients receiving treatment.
authors.affiliation: Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Suite 330S, Philadelphia, PA 19104, USA.
authors.forename: Auris O
authors.initials: AO
authors.lastname: Huen
authors.affiliation: Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Suite 330S, Philadelphia, PA 19104, USA. Electronic address: Ellen.Kim@uphs.upenn.edu.
authors.forename: Ellen J
authors.initials: EJ
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000077610:Bexarotene; D003131:Combined Modality Therapy; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D007037:Hypothyroidism / Q000139:chemically induced; D007155:Immunologic Factors / Q000627:therapeutic use*; D007372:Interferons / Q000627:therapeutic use; D009182:Mycosis Fungoides / Q000188:drug therapy*; D011701:PUVA Therapy; D012176:Retinoids / Q000627:therapeutic use*; D012751:Sezary Syndrome / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013764:Tetrahydronaphthalenes / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors; D012176:Retinoids; D013764:Tetrahydronaphthalenes; D007372:Interferons; D000077610:Bexarotene
keywords: Acitretin; Bexarotene; Cutaneous T-cell lymphoma; Isotretinoin; Mycosis fungoides; Retinoids; Rexinoids; Sézary syndrome