title: Neuroendocrine tumor arising de novo in the left upper thigh: a case report.
abstract: Neuroendocrine tumors (NETs) originate in the neuroendocrine cells of the neural crest (Kulchitsky cells). If neuroendocrine tumors arising in the digestive tract or lung may occasionally result in skin metastases, primary soft tissue or skin NETs are infrequent. The current paper presents the case of an elderly woman patient with neuroendocrine tumors arising de novo in the left upper thigh, accompanied by lymph nodes metastases in the left groin and in the left pelvic sidewall, in close vicinity of the iliac vessels. The diagnosis of NET was performed based on immunohistochemical tests. Such tumors show a slow growth and, generally, have a good prognosis. It is emphasized that complete surgical excision, in some cases associated with adjuvant external radiotherapy is the optimal therapeutic modality in dealing with such lesions.
authors.affiliation: Department of General Surgery, Railroads Clinical Hospital, Craiova, Romania; dripaun@gmail.com.
authors.forename: Ion
authors.initials: I
authors.lastname: Păun
authors.forename: Andrei
authors.initials: A
authors.lastname: Costin
authors.forename: Mariana
authors.initials: M
authors.lastname: Păun
authors.forename: Mihaela
authors.initials: M
authors.lastname: Ţenovici
authors.forename: Claudia Valentina
authors.initials: CV
authors.lastname: Georgescu
authors.forename: Corneliu Cristian
authors.initials: CC
authors.lastname: Georgescu
authors.forename: Vlad Denis
authors.initials: VD
authors.lastname: Constantin
mesh_terms: D000368:Aged; D005260:Female; D006119:Groin / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008168:Lung / Q000473:pathology; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D009432:Neural Crest / Q000473:pathology; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010388:Pelvis / Q000473:pathology; D011379:Prognosis; D011878:Radiotherapy; D012867:Skin / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D013848:Thigh / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D019394:Ki-67 Antigen