title: Determinants of preclinical atherosclerosis are different in type 1 and type 2 diabetic women.
abstract: Diabetes mellitus type 2 ranks among the strongest predictors of cardiovascular diseases (CVD) while the association of type 1 diabetes with CVD is more complex. We studied differences between type 1 and 2 diabetic women regarding association of cardiovascular risk factors with preclinical atherosclerosis expressed as intima-media thickness of common carotid (IMT CCA) and femoral arteries (IMT CFA) measured by high resolution ultrasound. Women with type 1 (n=203) and type 2 diabetes (n=123) were examined with regard to the presence of cardiovascular risk factors. In type 1 diabetic women strong association between IMT CCA and body mass index, waist circumference, and total body fat was found in contrast to type 2 diabetic women. In type 2 diabetic women strong association between IMT CCA and fasting glucose, glycated hemoglobin, and atherogenic index of plasma (log TG/HDL cholesterol) was observed in contrast to type 1 diabetic women. In type 1 diabetic women, IMT CFA was associated with body fat in contrast to type 2 diabetic women. Preclinical atherosclerosis in type 1 diabetic women was strongly associated with factors reflecting body fat and its distribution, while in type 2 diabetic women preclinical atherosclerosis was associated with markers reflecting glucose and lipid metabolic disorders.
authors.affiliation: Clinic of Internal Medicine, Second Medical Faculty and Teaching Hospital Motol, Charles University in Prague, Prague, Czech Republic. pavlina.pithova@fnmotol.cz.
authors.forename: P
authors.initials: P
authors.lastname: Piťhová
authors.forename: K
authors.initials: K
authors.lastname: Štechová
authors.forename: J
authors.initials: J
authors.lastname: Piťha
authors.forename: V
authors.initials: V
authors.lastname: Lánská
authors.forename: M
authors.initials: M
authors.lastname: Kvapil
mesh_terms: D000328:Adult; D000367:Age Factors; D050197:Atherosclerosis / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D001786:Blood Glucose