title: Continued pregnancy and vaginal delivery after 32 weeks of gestation for monoamniotic twins.
abstract: OBJECTIVE
  To report the outcomes of 38 monoamniotic twin pregnancies managed homogeneously to assess whether continuing the pregnancy past 32 weeks of gestation and vaginal delivery are reasonable options.
  
  
  METHODS
  Single-centre retrospective study including all monoamniotic pregnancies managed over a 20-year period at Port-Royal Obstetrics Department, Paris, France.
  
  
  METHODS
  In the study department, both continuation of the pregnancy up to 36 weeks of gestation and vaginal delivery are allowed for monoamniotic pregnancies in some conditions. Perinatal outcomes are described and then compared according to mode of delivery for patients who gave birth at or after 32 weeks of gestation.
  
  
  RESULTS
  Three of the 38 pregnancies included fetal malformations; in two of these cases, both fetuses died in utero at 26 weeks of gestation. In cases without malformations, one twin died in utero in two women at 28.0 and 29.2 weeks of gestation, and both fetuses died in two other women at 24.0 and 24.5 weeks of gestation. Mean gestational age at delivery was 32.9 weeks (range 24.0-36.3). Five women gave birth between 22 and 26 weeks of gestation, six women gave birth between 27 and 31 weeks of gestation, and 27 women gave birth at or after 32 weeks of gestation (26 after excluding those with fetal malformations). No intrauterine or neonatal deaths were observed at or after 32 weeks of gestation. The 28 infants delivered vaginally did not differ significantly from the 22 infants born by caesarean section in terms of umbilical artery pH or 5-min Apgar scores.
  
  
  CONCLUSIONS
  Continuation of monoamniotic pregnancies beyond 32 weeks of gestation and trial of vaginal delivery are both reasonable options if the parents agree, and optimal surveillance is provided.
authors.affiliation: Maternité Port-Royal, University Paris-Descartes, Department of Obstetrics and Gynaecology, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; PremUp Foundation for Scientific Cooperation in Connection with Pregnancy and Prematurity, Paris, France; DHU Risk in Pregnancy, Paris, France. Electronic address: olivia.anselem@cch.aphp.fr.
authors.forename: O
authors.initials: O
authors.lastname: Anselem
authors.affiliation: Maternité Port-Royal, University Paris-Descartes, Department of Obstetrics and Gynaecology, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; PremUp Foundation for Scientific Cooperation in Connection with Pregnancy and Prematurity, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Mephon
authors.affiliation: Maternité Port-Royal, University Paris-Descartes, Department of Obstetrics and Gynaecology, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; PremUp Foundation for Scientific Cooperation in Connection with Pregnancy and Prematurity, Paris, France; DHU Risk in Pregnancy, Paris, France; INSERM U1153, Obstetrical, Perinatal and Paediatric Epidemiology Research Team, Research Centre for Epidemiology and Biostatistics Sorbonne Paris Cité, Paris Descartes University, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Le Ray
authors.affiliation: Maternité Port-Royal, University Paris-Descartes, Department of Obstetrics and Gynaecology, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; PremUp Foundation for Scientific Cooperation in Connection with Pregnancy and Prematurity, Paris, France; DHU Risk in Pregnancy, Paris, France; INSERM U1153, Obstetrical, Perinatal and Paediatric Epidemiology Research Team, Research Centre for Epidemiology and Biostatistics Sorbonne Paris Cité, Paris Descartes University, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Marcellin
authors.affiliation: Maternité Port-Royal, University Paris-Descartes, Department of Obstetrics and Gynaecology, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; PremUp Foundation for Scientific Cooperation in Connection with Pregnancy and Prematurity, Paris, France; DHU Risk in Pregnancy, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Cabrol
authors.affiliation: Maternité Port-Royal, University Paris-Descartes, Department of Obstetrics and Gynaecology, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; PremUp Foundation for Scientific Cooperation in Connection with Pregnancy and Prematurity, Paris, France; DHU Risk in Pregnancy, Paris, France; INSERM U1153, Obstetrical, Perinatal and Paediatric Epidemiology Research Team, Research Centre for Epidemiology and Biostatistics Sorbonne Paris Cité, Paris Descartes University, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Goffinet
mesh_terms: D000328:Adult; D001034:Apgar Score; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005865:Gestational Age; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D008297:Male; D011247:Pregnancy; D011255:Pregnancy Maintenance; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D012189:Retrospective Studies; D014469:Umbilical Arteries; D055815:Young Adult
keywords: Fetal death; Fetal surveillance; Mode of delivery; Monoamniotic twin pregnancies; Perinatal mortality