title: Evaluation of stability and capsular bag opacification with a foldable intraocular lens coupled with a protective membrane in the rabbit model.
abstract: OBJECTIVE
  To evaluate the stability and capsular bag opacification of a smooth or a patterned silicone protective membrane implanted in the bag with secondary placement of an intraocular lens (IOL).
  
  
  METHODS
  John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Twelve New Zealand rabbits had bilateral implantation of a protective membrane and an IOL or an IOL alone. Three groups of 8 eyes each received the IOL and the smooth protective membrane, the IOL and the patterned membrane, or the IOL alone. Slitlamp examination was performed weekly for 4 weeks. The rabbits were then humanely killed and their globes enucleated. Capsular bag opacification was scored based on the Miyake-Apple view, and the eyes underwent histopathology.
  
  
  RESULTS
  At 4 weeks, the mean central posterior capsule opacification (PCO) score was 0.28 ± 0.32 (SD) in all eyes with a protective membrane and 2.08 ± 1.28 in eyes with the IOL alone (P < .00001, Student t test). Peripheral PCO and Soemmerring ring formation were also significantly less in eyes with the protective membrane. Histopathologically, the posterior capsules were relatively clear in most IOLs with the protective membrane. The smooth and patterned protective membranes showed a significant difference in overall capsular bag opacification formation compared with the IOLs without the membrane.
  
  
  CONCLUSIONS
  The circular geometry of the protective membrane led to expansion of the capsular bag and appeared to prevent capsular bag opacification. Further studies are warranted to assess whether the pattern on the device's posterior surface further enhances this effect.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Kramer
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Electronic address: liliana.werner@hsc.utah.edu.
authors.forename: Liliana
authors.initials: L
authors.lastname: Werner
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Kyle
authors.initials: K
authors.lastname: MacLean
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Aabid
authors.initials: A
authors.lastname: Farukhi
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Gareth L
authors.initials: GL
authors.lastname: Gardiner
authors.affiliation: From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Nick
authors.initials: N
authors.lastname: Mamalis
mesh_terms: D000818:Animals; D058442:Capsule Opacification / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D020099:Coated Materials, Biocompatible; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D023421:Models, Animal; D018918:Phacoemulsification; D011474:Prosthesis Design; D011817:Rabbits; D012826:Silicone Elastomers
chemical_list: D020099:Coated Materials, Biocompatible; D012826:Silicone Elastomers