title: Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases.
abstract: Oxidative stress plays a role in many different forms of neurodegenerative ocular disease. The imbalance between the generation of endogenous reactive oxygen species (ROS) and their corresponding neutralization by endogenous antioxidant defense systems leads to cellular oxidative stress, oxidation of different bio-macromolecules, and eventually retinal disease. As a result, the administration of supplemental endogenous antioxidant materials or exogenous ROS scavengers is an interesting therapeutic approach for the treatment of forms of ocular disease associated with oxidative stress. Thus far, different dietary antioxidant supplements have been proven to be clinically reliable and effective, and different antioxidant gene therapy approaches are under investigation. In addition, various metal oxide nanoparticles were shown to be effective in defending against oxidative stress-associated injury. These benefits are due to free radical scavenging properties of the materials arising from non-stoichiometric crystal defects and oxygen deficiencies. Here we discuss the application of this approach to the protection of the retina.
authors.affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., BMSB 781, 73104, Oklahoma City, OK, USA. rajendra-mitra@ouhsc.edu.
authors.forename: Rajendra N
authors.initials: RN
authors.lastname: Mitra
authors.affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., BMSB 781, 73104, Oklahoma City, OK, USA. shannon-Conley@ouhsc.edu.
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Conley
authors.affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., BMSB 781, 73104, Oklahoma City, OK, USA. muna-naash@ouhsc.edu.
authors.forename: Muna I
authors.initials: MI
authors.lastname: Naash
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D005128:Eye Diseases / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D050997:Nanomedicine / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D012160:Retina / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D028581:Lanthanoid Series Elements; D017382:Reactive Oxygen Species
keywords: Age-related macular degeneration; Antioxidant; Diabetic retinopathy; Enzymes; Glaucoma; Light damage; Mice; Nanoparticle; Oxidative stress; ROS; Rat; Rescue; Retinitis pigmentosa; Vitamins