title: Age-associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair.
abstract: Mesenchymal stem cells (MSCs) represent an ideal source of autologous cell-based therapy for chronic wounds. Functional characteristics of MSCs may benefit wound healing by exerting their multi-regenerative potential. However, cell ageing resulting from chronic degenerative diseases or donor age could cause inevitable effects on the regenerative abilities of MSCs. A variety of studies have shown the relationship between MSC ageing and age-related dysfunction, but few associate these age-related impacts on MSCs with their ability of repairing chronic wounds, which are common in the elderly population. Here, we discuss the age-associated changes of MSCs and describe the potential impacts on MSC-based therapy for chronic wounds. Furthermore, critical evaluation of the current literatures is necessary for understanding the underlying mechanisms of MSC ageing and raising the corresponding concerns on considering their possible use for chronic wound repair.
authors.affiliation: Key Laboratory of Wound Repair and Regeneration of PLA, The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P. R. China.|School of Medicine, Nankai University, Tianjin, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yao
authors.affiliation: Key Laboratory of Wound Repair and Regeneration of PLA, The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P. R. China.|Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, P. R. China.|Hainan Branch of the Chinese PLA General Hospital, Sanya, P. R. China.
authors.forename: Sha
authors.initials: S
authors.lastname: Huang
authors.affiliation: Key Laboratory of Wound Repair and Regeneration of PLA, The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P. R. China.|Department of Oncology, Dongtai People's Hospital, Dongtai, P. R. China.
authors.forename: Dongyun
authors.initials: D
authors.lastname: Gao
authors.affiliation: Key Laboratory of Wound Repair and Regeneration of PLA, The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P. R. China.|Graduate School of Tianjin Medical University, Tianjin, P. R. China.
authors.forename: Jiangfan
authors.initials: J
authors.lastname: Xie
authors.affiliation: Key Laboratory of Wound Repair and Regeneration of PLA, The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P. R. China.|Department of Thoracic and Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, P. R. China.
authors.forename: Nanbo
authors.initials: N
authors.lastname: Liu
authors.affiliation: Key Laboratory of Wound Repair and Regeneration of PLA, The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P. R. China.|Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, P. R. China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fu
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation / Q000502:physiology*; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D008875:Middle Aged; D012038:Regeneration / Q000502:physiology; D012307:Risk Factors; D012867:Skin / Q000293:injuries; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000175:diagnosis* / Q000628:therapy*
keywords: Ageing; Chronic wound; Mesenchymal stem cells (MSCs); Regenerative capabilities