title: Validation of the Spanish version of the Baylor Profound Mental Status Examination.
abstract: BACKGROUND
  There are no short valid instruments to evaluate cognitive status in severe Alzheimer's disease (AD) patients in the Spanish language.
  
  
  OBJECTIVE
  To validate the Spanish version of the Baylor Profound Mental Status Examination (BPMSE-Sp).
  
  
  METHODS
  The Baylor Profound Mental Status Examination (BPMSE) was translated to Spanish and back translated. Validation was conducted in 100 patients with severe probable AD with a Mini-Mental State Examination (MMSE) <12. We assessed internal consistency (Cronbach's alpha), concurrent validity (Pearson's correlations) with the MMSE, Severe Impairment Battery (SIB), Neuropsychiatric Inventory Short Form (NPI-Q) and the Functional Assessment Staging and reliability.
  
  
  RESULTS
  The mean age of patients was 84.9; 74% were female; 64% were institutionalized. The mean MMSE was 5.6; the mean BPMSE-Sp was 13.6; the mean BPMSE-Sp behavior was 1.2; the mean SIB was 42.2; and the mean NPI-Q was 4.7. BPMSE-Sp presented good internal consistency (Cronbach α= 0.84). There were significant correlations between the BPMSE-Sp and MMSE (r = 0.86, p <  0.001), and between the BPMSE-Sp and SIB (r = 0.92, p <  0.001). Inter-rater and test-retest reliability were in both cases excellent, ranging between 0.96 and 0.99 (p <  0.001). BPMSE-Sp had fewer floor and ceiling effects than the MMSE.
  
  
  CONCLUSIONS
  The BPMSE-Sp is a valid tool for use in daily practice and research in the evaluation of cognitive function of patients with severe AD.
authors.affiliation: Department of Geriatrics, Hospital General de Villarrobledo, Albacete, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Salmerón
authors.affiliation: Department of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Huedo
authors.affiliation: Department of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
authors.forename: Melisa
authors.initials: M
authors.lastname: López-Utiel
authors.affiliation: Department of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Soler-Moratalla
authors.affiliation: Department of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Flores-Ruano
authors.affiliation: Department of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Fernández-Sánchez
authors.affiliation: Department of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Noguerón
authors.affiliation: Department of Neurology and Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Rachelle S
authors.initials: RS
authors.lastname: Doody
authors.affiliation: Department of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Abizanda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008609:Mental Status Schedule / Q000592:standards*; D009483:Neuropsychological Tests; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013030:Spain
keywords: Alzheimer’s disease; Baylor Profound Mental Status Examination; severe dementia; validation