title: Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants.
abstract: Basic transcriptional machinery in eukaryotes is assisted by a number of cofactors, which either increase or decrease the rate of transcription. Mediator complex is one such cofactor, and recently has drawn a lot of interest because of its integrative power to converge different signaling pathways before channeling the transcription instructions to the RNA polymerase II machinery. Like yeast and metazoans, plants do possess the Mediator complex across the kingdom, and its isolation and subunit analyses have been reported from the model plant, Arabidopsis. Genetic, and molecular analyses have unraveled important regulatory roles of Mediator subunits at every stage of plant life cycle starting from flowering to embryo and organ development, to even size determination. It also contributes immensely to the survival of plants against different environmental vagaries by the timely activation of its resistance mechanisms. Here, we have provided an overview of plant Mediator complex starting from its discovery to regulation of stoichiometry of its subunits. We have also reviewed involvement of different Mediator subunits in different processes and pathways including defense response pathways evoked by diverse biotic cues. Wherever possible, attempts have been made to provide mechanistic insight of Mediator's involvement in these processes.
authors.affiliation: Plant Mediator Lab, National Institute of Plant Genome Research New Delhi, India.
authors.forename: Subhasis
authors.initials: S
authors.lastname: Samanta
authors.affiliation: Plant Mediator Lab, National Institute of Plant Genome Research New Delhi, India.
authors.forename: Jitendra K
authors.initials: JK
authors.lastname: Thakur
keywords: Arabidopsis; RNA polymerase II; abiotic stress; defense signaling; development; mediator complex; rice; transcription