title: Efficacy Study of Broken Rice Maltodextrin in In Vitro Wound Healing Assay.
abstract: Maltodextrins that contain both simple sugars and polymers of saccharides have been widely used as ingredients in food products and pharmaceutical delivery systems. To date, no much work has been reported on the applications of maltodextrin from broken rice (RB) sources. Therefore, the objective of this work was to investigate the in vitro wound healing efficacy of RB maltodextrin at different conditions. Wounds treated with lower dextrose equivalent (DE) range (DE 10-14) of maltodextrins at a concentration of 10% obtained from RB were found to be able to heal the wounds significantly faster (p < 0.01) than maltodextrin with higher DE ranges (DE 15-19 and DE 20-24) and concentrations of 5% and 20%. The findings from both BrdU and MTT assay further confirmed its wound healing properties as the NIH 3T3 fibroblast wounded cells were able to proliferate without causing cytotoxic effect when wounded cell was treated with maltodextrin. All these findings indicated that the RB maltodextrin could perform better than the commercial maltodextrin at the same DE range. This study showed that RB maltodextrins had better functionality properties than other maltodextrin sources and played a beneficial role in wound healing application.
authors.affiliation: Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Zahiah
authors.initials: Z
authors.lastname: Mohamed Amin
authors.affiliation: Biotechnology Research Center, Malaysian Agricultural Research & Development Institute (MARDI) Headquarters, P.O. Box 12301, 50774 Serdang, Selangor, Malaysia.
authors.forename: Soo Peng
authors.initials: SP
authors.lastname: Koh
authors.affiliation: Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Swee Keong
authors.initials: SK
authors.lastname: Yeap
authors.affiliation: Biotechnology Research Center, Malaysian Agricultural Research & Development Institute (MARDI) Headquarters, P.O. Box 12301, 50774 Serdang, Selangor, Malaysia.
authors.forename: Nur Syazwani
authors.initials: NS
authors.lastname: Abdul Hamid
authors.affiliation: Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Chin Ping
authors.initials: CP
authors.lastname: Tan
authors.affiliation: Biotechnology Research Center, Malaysian Agricultural Research & Development Institute (MARDI) Headquarters, P.O. Box 12301, 50774 Serdang, Selangor, Malaysia.
authors.forename: Kamariah
authors.initials: K
authors.lastname: Long
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D012275:Oryza / Q000737:chemistry*; D011134:Polysaccharides / Q000494:pharmacology*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D011134:Polysaccharides; C008315:maltodextrin; D001973:Bromodeoxyuridine