title: Liver fluke-infested graft used for living-donor liver transplantation: case report and review of the literature.
abstract: Clonorchiasis is a cholangiopathy caused by foodborne trematode parasites, also known as liver flukes. Clonorchiasis is endemic in a wide geographical area extending from Eastern Europe to Southeast Asia. Infested hosts may remain asymptomatic for decades and consequently their liver can become available as a graft. To date, 20 liver transplantations with liver fluke-infested grafts have been reported in the literature. All of them occurred in Asian countries. We, here, report the first case to our knowledge in the Western world of living-donor liver transplantation (LDLT) with an Opisthorchis felineus-infested graft, and present a review of the literature. A 6-month-old girl with decompensated secondary biliary cirrhosis underwent an LDLT with a left lateral graft infested with O. felineus. After prompt diagnosis and adequate therapy, both donor and recipient had an uneventful postoperative course and long-term follow-up. Liver grafts infested with liver flukes do not pose a contraindication to liver donation from deceased or living donors, provided that a correct diagnosis and treatment are performed in a timely fashion.
authors.affiliation: General, Visceral and Transplant Surgery, University Hospital Tuebingen, Tuebingen, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Capobianco
authors.affiliation: Institute of Tropical Medicine, Travel Medicine, Human Parasitology, University Hospital Tuebingen, Tuebingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Frank
authors.affiliation: General, Visceral and Transplant Surgery, University Hospital Tuebingen, Tuebingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Königsrainer
authors.affiliation: Institute of Pathology, University Hospital Tuebingen, Tuebingen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Sipos
authors.affiliation: General, Visceral and Transplant Surgery, University Hospital Tuebingen, Tuebingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Menzel
authors.affiliation: Department of Pediatric Gastroenterology and Hepatology, University Hospital Tuebingen, Tuebingen, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Sturm
authors.affiliation: General, Visceral and Transplant Surgery, University Hospital Tuebingen, Tuebingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Nadalin
mesh_terms: D000328:Adult; D000818:Animals; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000635:transmission*; D005260:Female; D006801:Humans; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors
keywords: Clonorchis sinensis; Opisthorchis felineus; clonorchiasis; liver flukes; liver transplantation; living donor; living-donor liver transplantation; post-transplant infection