title: Palladium-Catalyzed Thioetherification of Quinolone Derivatives via Decarboxylative C-S Cross-Couplings.
abstract: A highly efficient and practical procedure for palladium-catalyzed direct thioetherification of quinolone derivatives with diaryl disulfides through decarboxylative C-S coupling has been established. The reaction could proceed smoothly under air in the presence of Pd(OAc)2 and Ag2 CO3 in DMSO. This protocol provides an appealing alternative to existing approaches to construct aryl sulfides of quinolone derivatives, which may be used as key intermediates in the synthesis of drug candidates.
authors.affiliation: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, China.|Pharmacy College, Zhejiang University of Technology, Hangzhou, 310014, China.
authors.forename: Chengcai
authors.initials: C
authors.lastname: Xia
authors.affiliation: Pharmacy College, Taishan Medical University, Tai'an, 271016, China.
authors.forename: Zhenjiang
authors.initials: Z
authors.lastname: Wei
authors.affiliation: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Pharmacy College, Zhejiang University of Technology, Hangzhou, 310014, China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Yu
authors.affiliation: Pharmacy College, Zhejiang University of Technology, Hangzhou, 310014, China.
authors.forename: Hanxiao
authors.initials: H
authors.lastname: Liao
authors.affiliation: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Shen
authors.affiliation: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, China. chxyzpf@hotmail.com.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhang
mesh_terms: D002244:Carbon / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry*; D018030:Silver Compounds / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry
chemical_list: D002254:Carbonates; D015363:Quinolones; D018030:Silver Compounds; D010165:Palladium; D013455:Sulfur; D002244:Carbon; C033260:silver carbonate
keywords: C−S coupling; decarboxylative; palladium; quinolone derivatives; thioetherification