title: ncRDeathDB: A comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system.
abstract: Programmed cell death (PCD) is a critical biological process involved in many important processes, and defects in PCD have been linked with numerous human diseases. In recent years, the protein architecture in different PCD subroutines has been explored, but our understanding of the global network organization of the noncoding RNA (ncRNA)-mediated cell death system is limited and ambiguous. Hence, we developed the comprehensive bioinformatics resource (ncRDeathDB, www.rna-society.org/ncrdeathdb ) to archive ncRNA-associated cell death interactions. The current version of ncRDeathDB documents a total of more than 4600 ncRNA-mediated PCD entries in 12 species. ncRDeathDB provides a user-friendly interface to query, browse and manipulate these ncRNA-associated cell death interactions. Furthermore, this resource will help to visualize and navigate current knowledge of the noncoding RNA component of cell death and autophagy, to uncover the generic organizing principles of ncRNA-associated cell death systems, and to generate valuable biological hypotheses.
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Deng
authors.initials: D
authors.lastname: Wu
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.|b Bioinformatics Center; School of Life Science; University of Electronic Science and Technology of China ; Chengdu , China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Kang
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Kongning
authors.initials: K
authors.lastname: Li
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Xiaoman
authors.initials: X
authors.lastname: Bi
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Nana
authors.initials: N
authors.lastname: Jin
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Hu
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Puwen
authors.initials: P
authors.lastname: Tan
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yi
authors.affiliation: c Department of Biochemistry and Molecular Biology, Shantou University Medical College ; Shantou , China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Shen
authors.affiliation: b Bioinformatics Center; School of Life Science; University of Electronic Science and Technology of China ; Chengdu , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: d Department of Pathology, Harbin Medical University ; Harbin , China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: c Department of Biochemistry and Molecular Biology, Shantou University Medical College ; Shantou , China.
authors.forename: Jianzhen
authors.initials: J
authors.lastname: Xu
authors.affiliation: a College of Bioinformatics Science and Technology; Harbin Medical University ; Harbin , China.|c Department of Biochemistry and Molecular Biology, Shantou University Medical College ; Shantou , China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D001343:Autophagy / Q000235:genetics*; D019295:Computational Biology; D030541:Databases, Genetic; D006801:Humans; D011506:Proteins / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D011506:Proteins; D022661:RNA, Untranslated
keywords: autophagy; cell death; crosstalk; database; ncRNA; network