title: A review of 42 cases of intestinal pseudo-obstruction in patients with systemic lupus erythematosus based on case reports.
abstract: Intestinal pseudo-obstruction (IpsO) is considered a severe manifestation of systemic lupus erythematosus (SLE) characterized by clinical and radiological evidence of intestinal obstruction with no identifiable mechanical lesion. We performed a systematic review to document IpsO in SLE. Twenty-eight articles with 42 patients were included. The median age of onset of IpsO was 27.5 (10-57) years. The female to male ratio was 38:4. Twenty-two (52.4%) patients had IpsO as the initial presentation of their underlying lupus. Three (7.1%) patients manifested in inactive lupus. The duration of abdominal symptoms before admitted ranged from 3 days to 3 years, however most of the patients responded well to systemic corticosteroid or immunosuppressive treatment within 2 days to about 3 months. Concomitant ureterohydronephrosis was present in approximately three-fourths of the cases. More interestingly, 4 patients presented hepatobiliary dilatation without mechanical obstruction together with IPO and ureterohydronephrosis. In conclusion, IpsO is an uncommon but important manifestation of SLE. The finding of coexisting ureterohydronephrosis and hepatobiliary dilatation suggests that there may be generalized visceral muscle dysmotility. Early recognition of IpsO is necessary to institute appropriate medical treatment and to avoid inappropriate surgical intervention.
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: yfywk2014@163.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Jin
authors.affiliation: Department of Gerontology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Haining
authors.initials: H
authors.lastname: Zhi
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Haiwei
authors.initials: H
authors.lastname: Du
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Rongjiang
authors.initials: R
authors.lastname: Shao
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Shanyi
authors.initials: S
authors.lastname: Ge
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Surgery, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Junhua
authors.initials: J
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D012698:Serologic Tests; D055815:Young Adult
chemical_list: D001323:Autoantibodies
keywords: Diagnose; Intestinal pseudo-obstruction; Systemic lupus erythematosus; Treatment