title: Occlusal traits in children with neurofibromatosis type 1.
abstract: OBJECTIVE
  Literature is poor of data about the occlusion in children affected by neurofibromatosis type 1 (NF1). This case-control study investigated the occlusal traits in a group of children with NF1.
  
  
  METHODS
  A hundred and fifteen children with NF1 were enrolled; non-NF1 controls were sequentially selected among subjects referred to the Pediatric Dentistry Department.
  
  
  METHODS
  All patients underwent a clinical dental examination and a panoramic radiography. The following orthodontic variables were considered: molar relationship, overjet, overbite, cross-bite, scissor bite, and crowding/spacing.
  
  
  RESULTS
  Class III molar relationship resulted significantly (p = 0.01) more common in children with NF1 than in the control group as well as the unilateral posterior cross-bite (p = 0.0017). Forty-three children with NF1 (37.3%) showed radiographic abnormalities; in one case, a plexiform neurofibroma was detected.
  
  
  CONCLUSIONS
  An early orthodontic evaluation might be planned in the management of children with NF1 to prevent or decrease the need for extensive orthodontic interventions.
authors.affiliation: Department of Paediatric Dentistry, Dental School, University of Brescia, Brescia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Bardellini
authors.affiliation: Department of Paediatric Dentistry, Dental School, University of Brescia, Brescia, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Tonni
authors.affiliation: Unit of Child Neurology and Psychiatry, Spedali Civili, Brescia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Micheli
authors.affiliation: Unit of Child Neurology and Psychiatry, Spedali Civili, Brescia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Molinaro
authors.affiliation: Department of Paediatric Dentistry, Dental School, University of Brescia, Brescia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Amadori
authors.affiliation: Department of Paediatric Dentistry, Dental School, University of Brescia, Brescia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Flocchini
authors.affiliation: Department of Paediatric Dentistry, Dental School, University of Bologna, Alma Mater Studiorum, Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Piana
authors.affiliation: Department of Paediatric Dentistry, Dental School, University of Brescia, Brescia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Majorana
mesh_terms: D016022:Case-Control Studies; D002648:Child; D006801:Humans; D008310:Malocclusion; D009456:Neurofibromatosis 1; D057887:Overbite
keywords: child; dental occlusion; neurofibromatoses