title: Effect of Huqian Wan on liver-Yin and kidney-Yin deficiency patterns in patients with knee osteoarthritis.
abstract: OBJECTIVE
  To observe the curative effect of Huqian Wan on liver and kidney-Yin deficiency knee osteoarthritis (KOA).
  
  
  METHODS
  One hundred patients were randomly divided, into a treatment (50 patients) and control group (50 patients). In the treatment group, patients orally took the Chinese medicine Huqian Wan. Control group patients orally took Votalin, 75 mg, once a day, for 8 weeks. The visual analog scale (VAS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and Medical Outcomes Study Short Form 36-Item Health Survey (SF 36) were used to evaluate the curative effect before treatment and after 8 and 16 weeks of treatment.
  
  
  RESULTS
  VAS and WOMAC scores significantly decreased and SF 36 scores significantly increased after treatment in both groups compared with before treatment (P < 0.05). There were significant differences in VAS, WOMAC, and SF 36 score changes between the two groups at week 16 (P < 0.05). There was a significant increase in VAS and WOMAC scores in the control groups (P < 0.05) between weeks 8 and 16, but no significant difference was found in the treatment group (P > 0.05).
  
  
  CONCLUSIONS
  Huqian Wan could effectively improve the clinical symptoms and quality of life in patients with KOA. It could also have a better and longer lasting curative effect without obvious adverse events compared with Votalin.
authors.forename: Chen
authors.initials: C
authors.lastname: Qiqing
authors.forename: Jin
authors.initials: J
authors.lastname: Hongting
authors.forename: He
authors.initials: H
authors.lastname: Bin
authors.forename: Wang
authors.initials: W
authors.lastname: Liang
authors.forename: Xiao
authors.initials: X
authors.lastname: Luwei
authors.forename: Tong
authors.initials: T
authors.lastname: Peijian
mesh_terms: D000368:Aged; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome; D016710:Yin Deficiency / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D004365:Drugs, Chinese Herbal