title: Two markers in predicting the cardiovascular events in patients with polycystic ovary syndrome: increased P-wave and QT dispersion.
abstract: OBJECTIVE
  Polycystic ovary syndrome (PCOS) is a prevalent disease with many potential long-term cardiovascular risks. P-wave dispersion (Pdis) and QT dispersion (QTdis) have been shown to be noninvasive electrocardiographic predictors for development of cardiac arrhythmias. In this study we aimed to search Pdis and QTdis parameters in patients with PCOS.
  
  
  METHODS
  The study included 82 patients with PCOS and 74 age- and sex-matched healthy controls. Baseline 12-lead electrocardiographic and transthoracic echocardiographic measurements were evaluated. P-wave maximum duration (Pmax), P-wave minimum duration (Pmin), Pdis, QT interval, heart rate-corrected QT dispersion and QTdis were calculated by two cardiologists.
  
  
  RESULTS
  Patients wirh PCOS had significantly higher QT dispersion (49.5 ± 14.1 vs. 37.9 ± 12.6 ms, p < 0.001), and P wave dispersion (54.2 ± 11.4 vs. 45.9 ± 10.1 ms, p < 0.001) than the controls. Serum testosterone and estradiol levels was correlated with the Pdis (r = 0.677, p < 0.001 and r = 0.415, p < 0.001 respectively) and QTdis (r = 0.326, p < 0.001 and r = 0.321, p < 0.001 respectively).
  
  
  CONCLUSIONS
  Pdis and QTdis are simple and useful electrocardiographic markers which may be used in the prediction of the risk of adverse cardiovascular events in PCOS patients.
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey. sercardiocon@hotmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Akdag
authors.forename: N
authors.initials: N
authors.lastname: Cim
authors.forename: R
authors.initials: R
authors.lastname: Yildizhan
authors.forename: A
authors.initials: A
authors.lastname: Akyol
authors.forename: F
authors.initials: F
authors.lastname: Ozturk
authors.forename: N
authors.initials: N
authors.lastname: Babat
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D003430:Cross-Sectional Studies; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000473:pathology