title: Did studies on HFOV fail to improve ARDS survival because they did not decrease VILI? On the potential validity of a physiological concept enounced several decades ago.
abstract: High frequency oscillatory ventilation (HFOV) has been the subject of extensive physiological research for 30 years and even more so of an intense debate on its potential usefulness in the treatment of acute respiratory distress syndrome (ARDS). This technique has been enthusiastically promoted by some teams until two high-quality randomized clinical trials in adults with ARDS showed that HFOV did not decrease and might have even increased mortality. As a consequence of these results, physiological concepts such as atelectrauma and biotrauma on which ARDS management with HFOV were based should be reexamined. In contrast, the concept of volutrauma, i.e., end-inspiratory overdistension, as the cause for ventilator-induced lung injury might help explain excess mortality during mechanical ventilation of ARDS when inspiratory volumes are too high. This is what might have happened during one of the recent studies on HFOV. Failure of this complex technique must be put in perspective with the dramatic improvement of ARDS prognosis with very simple interventions such as tidal volume reduction, early pharmacological paralysis, and prone positioning which all limited end-inspiratory volume.
authors.affiliation: Service de Réanimation Médico-Chirurgicale, Hôpital Louis Mourier, AP-HP, 92700, Colombes, France. didier.dreyfuss@lmr.aphp.fr.|UMR 1137, IAME, INSERM, 75018, Paris, France. didier.dreyfuss@lmr.aphp.fr.|UMR 1137, IAME, Univ Paris Diderot, Sorbonne Paris Cité, 75018, Paris, France. didier.dreyfuss@lmr.aphp.fr.
authors.forename: Didier
authors.initials: D
authors.lastname: Dreyfuss
authors.affiliation: Service de Réanimation Médico-Chirurgicale, Hôpital Louis Mourier, AP-HP, 92700, Colombes, France.|UMR 1137, IAME, INSERM, 75018, Paris, France.|UMR 1137, IAME, Univ Paris Diderot, Sorbonne Paris Cité, 75018, Paris, France.
authors.forename: Jean-Damien
authors.initials: JD
authors.lastname: Ricard
authors.affiliation: Service de Réanimation Médico-Chirurgicale, Hôpital Louis Mourier, AP-HP, 92700, Colombes, France.|UMR 1137, IAME, INSERM, 75018, Paris, France.|UMR 1123, ECEVE, Univ Paris Diderot, Sorbonne Paris Cité, 75018, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Gaudry
mesh_terms: D006612:High-Frequency Ventilation; D006801:Humans; D010829:Physiological Phenomena; D015203:Reproducibility of Results; D012128:Respiratory Distress Syndrome / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy*; D015996:Survival Rate; D013997:Time Factors; D055397:Ventilator-Induced Lung Injury / Q000517:prevention & control*
keywords: Atelectrauma; HFOV; PEEP; Ventilator-induced lung injury; Volutrauma