title: Metabolomics in childhood diabetes.
abstract: Recent increases in the incidence of both type 1 (T1D) and type 2 diabetes (T2D) in children and adolescents point to the importance of environmental factors in the development of these diseases. Metabolomic analysis explores the integrated response of the organism to environmental changes. Metabolic profiling can identify biomarkers that are predictive of disease incidence and development, potentially providing insight into disease pathogenesis. This review provides an overview of the role of metabolomic analysis in diabetes research and summarizes recent research relating to the development of T1D and T2D in children.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, 80045, USA.
authors.forename: Brigitte I
authors.initials: BI
authors.lastname: Frohnert
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, 80045, USA.
authors.forename: Marian J
authors.initials: MJ
authors.lastname: Rewers
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006801:Humans; D055432:Metabolomics / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: autoimmunity; diabetes; lipidomics; metabolomics