title: Effect of Kiwifruit on Bone Resorption in Ovariectomized Mice.
abstract: Kiwifruit is a good source of dietary components and has beneficial effects for health. In this study, we investigated the effects of two types of kiwifruit, green kiwifruit (GRK) and gold kiwifruit (GOK), on bone metabolism in ovariectomized (OVX) mice. Seven-week-old female Balb/c-strain mice were divided into four groups: sham-operated (sham) group, OVX group, and OVX mice that were fed a GRK-supplemented diet or GOK-supplemented diet. Freeze-dried GRK and GOK were prepared and added in the diet at a concentration of 3 g/100 g. After 9 wk, the mice were sacrificed, and the serum, uterus, and femurs were obtained. Final body weight did not differ significantly among the four groups. Compared to the sham group, uterine weight was significantly lower and serum C-terminal telopeptide of type I collagen (CTx) levels and receptor activator of NF-κB ligand (RANKL) mRNA expression of the whole femur were significantly higher in the OVX group. Compared to the OVX group, GRK, but not GOK, reduced serum CTx concentrations and RANKL mRNA expression of the whole femur without changes in uterine weight. These results suggest that the GRK inhibited bone resorption, which might be due to a decrease in RANKL mRNA expression in OVX mice.
authors.affiliation: Institute of Food, Nutrition and Human Health, Massey University.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Katsumata
authors.forename: Frances M
authors.initials: FM
authors.lastname: Wolber
authors.forename: Miki
authors.initials: M
authors.lastname: Tadaishi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tousen
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ishimi
authors.forename: Marlena C
authors.initials: MC
authors.lastname: Kruger
mesh_terms: D029042:Actinidia; D000818:Animals; D001862:Bone Resorption / Q000178:diet therapy*; D024042:Collagen Type I / Q000097:blood; D004032:Diet / Q000379:methods; D005260:Female; D005269:Femur / Q000378:metabolism* / Q000473:pathology; D005638:Fruit; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size; D010052:Ovariectomy; D010455:Peptides / Q000097:blood; D053245:RANK Ligand / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D014599:Uterus / Q000378:metabolism* / Q000473:pathology
chemical_list: D024042:Collagen Type I; D010455:Peptides; D053245:RANK Ligand; D012333:RNA, Messenger; C505689:Tnfsf11 protein, mouse; C052929:collagen type I trimeric cross-linked peptide