title: Does early-start renal replacement therapy improve outcomes for patients with acute kidney injury?
abstract: There is a paucity of high-quality evidence to guide clinicians on thresholds for commencement of renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI), and wide international practice variation. Wald et al. report a pilot randomized trial examining accelerated use of RRT for moderate AKI in the intensive care unit, providing a workable design for a definitive trial examining the timing of RRT in critical illness.
authors.affiliation: Adult Critical Care Unit, Royal London Hospital, Barts Health NHS Trust, London, UK.
authors.forename: John R
authors.initials: JR
authors.lastname: Prowle
authors.affiliation: UCL Centre for Nephrology, Royal Free Hospital, University College London Medical School, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Davenport
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D017582:Renal Replacement Therapy; D061665:Time-to-Treatment; D057832:Watchful Waiting