title: Cardiovascular protective effect of polysaccharide from Ophiopogon japonicus in diabetic rats.
abstract: Ophiopogon japonicus (Thunb.) Ker-Gawl is a well known traditional Chinese medicine used to treat cardiovascular and chronic inflammatory diseases for thousands of years. The present study was set up to investigate the protective effects of O. japonicus polysaccharide (OJP1) on cardiovascular injuries in diabetic rats. Results showed that OJP1 significantly reduced the MDA concentration and increased the activities of GPx, CAT and SOD in heart of diabetic rats. The levels of AGE, hs-CRP, sICAM-1, NO and ET-1 in diabetic rats were significantly reversed by OJP1 treatment. In addition, the level of ET-1 mRNA was decreased significantly, whereas eNOS mRNA level was increased after administration of OJP1. Meanwhile, the histopathological analysis showed that OJP1 alleviates the heart injury in diabetic rats. Together, these results suggest that OJP1 maintains the antioxidant enzyme levels and improves cardiovascular performance in diabetic rats.
authors.affiliation: Institute of Glycobiological Engineering/School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China; Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Sairong
authors.initials: S
authors.lastname: Fan
authors.affiliation: Institute of Glycobiological Engineering/School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China; Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Yingge
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Institute of Glycobiological Engineering/School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China; Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Institute of Glycobiological Engineering/School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China; Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Jin
authors.affiliation: Institute of Glycobiological Engineering/School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China; Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Lu
authors.affiliation: Institute of Glycobiological Engineering/School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China; Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: xmchen01@163.com.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D001786:Blood Glucose; D002317:Cardiovascular Agents; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental; D004195:Disease Models, Animal; D019332:Endothelin-1 / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism; D031441:Ophiopogon / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D020011:Protective Agents; D051381:Rats; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D002317:Cardiovascular Agents; D019332:Endothelin-1; D010936:Plant Extracts; D011134:Polysaccharides; D020011:Protective Agents; D000067759:Receptor for Advanced Glycation End Products; D002374:Catalase; D005979:Glutathione Peroxidase; D052250:Nitric Oxide Synthase Type III; D013482:Superoxide Dismutase
keywords: Antioxidant; Cardiovascular complication; Diabetes; Myocardial injury; Ophiopogon japonica polysaccharides