title: ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM.
abstract: Regarding public health in Brazil, a new scenario emerged with the establishment of universal rotavirus (RV) vaccination programs. Herein, the data from the five years of surveillance (2007-2012) of G- and P-type RV strains isolated from individuals with acute gastroenteritis in Brazil are reported. A total of 6,196 fecal specimens were investigated by ELISA and RT-PCR. RVs were detected in 19.1% (1,181/6,196). The peak of RV incidence moved from June-August to September. RV was detected less frequently (19.5%) among children ≤ 5 years than in older children and adolescents (6-18 years) (40.6%). Genotype distribution showed a different profile for each year: G2P[4] strains were most prevalent during 2007-2010, G9P[8] in 2011, and G12P[8] in 2012. Mixed infections (G1+G2P[4], G2+G3P[4]+P[8], G2+G12P[8]), unusual combinations (G1P[4], G2P[6]), and rare strains (G3P[3]) were also identified throughout the study period. Widespread vaccination may alter the RV seasonal pattern. The finding of RV disease affecting older children and adolescents after vaccine implementation has been reported worldwide. G2P[4] emergence most likely follows a global trend seemingly unrelated to vaccination, and G12, apparently, is emerging in the Brazilian population. The rapidly changing RV genotype patterns detected during this study illustrate a dynamic population of co-circulating wildtype RVs in Brazil.
authors.affiliation: Adolfo Lutz Institute, Sao Paulo, SP, BR.
authors.forename: Adriana
authors.initials: A
authors.lastname: Luchs
authors.affiliation: Adolfo Lutz Institute, Sao Paulo, SP, BR.
authors.forename: Audrey
authors.initials: A
authors.lastname: Cilli
authors.affiliation: Adolfo Lutz Institute, Sao Paulo, SP, BR.
authors.forename: Simone Guadagnucci
authors.initials: SG
authors.lastname: Morillo
authors.affiliation: Adolfo Lutz Institute, Sao Paulo, SP, BR.
authors.forename: Rita de Cássia Compagnoli
authors.initials: Rde C
authors.lastname: Carmona
authors.affiliation: Adolfo Lutz Institute, Sao Paulo, SP, BR.
authors.forename: Maria do Carmo Sampaio Tavares
authors.initials: Mdo C
authors.lastname: Timenetsky
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000821:virology*; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics*; D012189:Retrospective Studies; D012401:Rotavirus / Q000235:genetics*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology*; D022243:Rotavirus Vaccines; D012621:Seasons; D055815:Young Adult
chemical_list: D012367:RNA, Viral; D022243:Rotavirus Vaccines