title: A challenging case of ocular melanoma.
abstract: Ocular melanoma is a rare malignancy found in clinical practice. In this paper, we present a case of highly aggressive ocular melanoma, which was surgically removed at the Department of Ophthalmology and diagnosed at the Department of Pathology, Emergency University Hospital, Bucharest, Romania, using conventional histopathological techniques. Uveal melanoma, a subset of ocular melanoma, has a distinct behavior in comparison to cutaneous melanoma and has a widely divergent prognosis. Approximately half of patients with ocular melanoma will develop metastatic disease, predominantly with hepatic, pulmonary or cerebral location, over a 10 to 15 years period. No systemic therapy was associated with an evident clinical outcome for patients with advanced disease and overall survival rate remains poor.
authors.affiliation: Department of Pathology, Emergency University Hospital, Bucharest, Romania; eldarlight@yahoo.com.
authors.forename: Mariana
authors.initials: M
authors.lastname: Costache
authors.forename: Adrian Vasile
authors.initials: AV
authors.lastname: Dumitru
authors.forename: Oana Maria
authors.initials: OM
authors.lastname: Pătraşcu
authors.forename: Daniela Alina
authors.initials: DA
authors.lastname: Popa-Cherecheanu
authors.forename: Patricia
authors.initials: P
authors.lastname: Bădilă
authors.forename: Jeni Cătălina
authors.initials: JC
authors.lastname: Miu
authors.forename: Alexandru
authors.initials: A
authors.lastname: Procop
authors.forename: Manuela
authors.initials: M
authors.lastname: Popa
authors.forename: Mircea Ştefan
authors.initials: MŞ
authors.lastname: Tampa
authors.forename: Maria
authors.initials: M
authors.lastname: Sajin
authors.forename: Olga
authors.initials: O
authors.lastname: Simionescu
authors.forename: Monica Mihaela
authors.initials: MM
authors.lastname: Cîrstoiu
mesh_terms: D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009885:Ophthalmology; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012878:Skin Neoplasms; D013997:Time Factors; D014604:Uveal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D000096142:Cutaneous Malignant Melanoma; D000098943:Uveal Melanoma