title: Flat Electroretinography and Acute Visual Loss After Ocriplasmin Injection for Vitreomacular Adhesion Complicating Macular Schisis.
abstract: A 53-year-old woman with macular and diffuse retinoschisis complicated by presumed vitreomacular traction underwent unilateral intravitreal ocriplasmin injection. Within hours after injection, she noted a loss of vision and the perception of "negative" images in the treated eye. Electrophysiologic testing revealed flat waveforms, and optical coherence tomography (OCT) showed initial decreased central macular thickness at day 1, followed by massive increased macular thickness with subfoveal neurosensory retinal detachment at 1 week. Her central macular thickness on OCT slowly returned to baseline during a period of 1 month until development of a macula-off rhegmatogenous retinal detachment at 6 months after injection. The authors believe this unique case of vitreomacular adhesion and macular schisis complicated by post-injection visual loss and electroretinography changes may offer further insight into this unusual complication.
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Hale
authors.forename: Angela K
authors.initials: AK
authors.lastname: Au
authors.forename: Naomi S
authors.initials: NS
authors.lastname: Falk
authors.forename: Pawan
authors.initials: P
authors.lastname: Bhatnagar
authors.forename: Paul M
authors.initials: PM
authors.lastname: Beer
mesh_terms: D000208:Acute Disease; D001766:Blindness / Q000139:chemically induced* / Q000503:physiopathology; D004596:Electroretinography / Q000187:drug effects*; D005260:Female; D005341:Fibrinolysin / Q000009:adverse effects*; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D008875:Middle Aged; D010446:Peptide Fragments / Q000009:adverse effects*; D012160:Retina / Q000503:physiopathology; D041441:Retinoschisis / Q000209:etiology*; D000267:Tissue Adhesions / Q000150:complications / Q000188:drug therapy; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D020255:Vitreous Detachment / Q000150:complications / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents; D010446:Peptide Fragments; C054561:microplasmin; D005341:Fibrinolysin