title: On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons.
abstract: In order to understand the biological role of lipids in cell membranes, it is necessary to determine the mesoscopic structure of well-defined model membrane systems. Neutron and X-ray scattering are non-invasive, probe-free techniques that have been used extensively in such systems to probe length scales ranging from angstroms to microns, and dynamics occurring over picosecond to millisecond time scales. Recent developments in the area of phase separated lipid systems mimicking membrane rafts will be presented, and the underlying concepts of the different scattering techniques used to study them will be discussed in detail.
authors.affiliation: University of Graz, Institute of Molecular Biosciences, Biophysics Division, NAWI Graz, Humboldtstr. 50/III, Graz, Austria. georg.pabst@uni-graz.at and BioTechMed-Graz, Graz, Austria.
authors.forename: Drew
authors.initials: D
authors.lastname: Marquardt
authors.affiliation: Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA. katsarasj@ornl.gov and Joint Institute for Neutron Sciences, Oak Ridge, Tennessee 37831, USA.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Heberle
authors.affiliation: Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA. katsarasj@ornl.gov and Joint Institute for Neutron Sciences, Oak Ridge, Tennessee 37831, USA.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Nickels
authors.affiliation: University of Graz, Institute of Molecular Biosciences, Biophysics Division, NAWI Graz, Humboldtstr. 50/III, Graz, Austria. georg.pabst@uni-graz.at and BioTechMed-Graz, Graz, Austria.
authors.forename: Georg
authors.initials: G
authors.lastname: Pabst
authors.affiliation: Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA. katsarasj@ornl.gov and Joint Institute for Neutron Sciences, Oak Ridge, Tennessee 37831, USA.
authors.forename: John
authors.initials: J
authors.lastname: Katsaras
mesh_terms: D002462:Cell Membrane / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D021962:Membrane Microdomains / Q000737:chemistry; D056004:Molecular Dynamics Simulation; D033363:Neutron Diffraction; D014961:X-Ray Diffraction
chemical_list: D008051:Lipid Bilayers