title: Genetic variations in vitamin D receptor were associated with the outcomes of hepatitis C virus infection among Chinese population.
abstract: Vitamin D has been considered as an immune modulator, and exerted the effect through the vitamin D receptor (VDR). This study investigated the associations of single-nucleotide polymorphisms (SNPs) of VDR with the outcomes of Hepatitis C virus (HCV) infection. Three SNPs (rs2228570, rs757343 and rs739837) were genotyped by TaqMan assay among Chinese population, including 538 HCV spontaneous clearance subjects, 834 persistent infection subjects and 1030 uninfected subjects. Binary logistic analyses were used to control the effects of confounding factors. The results showed that subjects with the rs757343 A allele and rs739837 A allele had the significantly reduced risk of HCV susceptibility (all PBonferroni<0.05 in dominant/additive model). In the stratified analysis, the protection of rs757343 A allele and rs739837 A allele against HCV infection remained effective in some subgroups. In addition, patients carrying rs739837 CA genotype were less prone to develop persistent infection (PBonferroni=0.033) and such effect still work in several subgroups in the stratified analysis. Furthermore, haplotype analysis indicated that when compared with the most frequent GC haplotype, the haplotype carrying AA (odds ratio (OR)=0.66, 95% confidence interval (CI)=0.56-0.78) and GA (OR=0.64, 95% CI=0.47-0.85) suggested a protective effect. Our findings indicated that the polymorphisms of VDR are associated with the outcomes of HCV infection among Chinese population.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Jiangsu, China.
authors.forename: Meng-ping
authors.initials: MP
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Jiangsu, China.
authors.forename: Jin-wei
authors.initials: JW
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Jiangsu, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China.
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Han
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Jiangsu, China.|Institute of Epidemiology and Microbiology, Huadong Research Institute for Medicine and Biotechnics, Jiangsu, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Jiangsu, China.
authors.forename: Zhi-hang
authors.initials: ZH
authors.lastname: Peng
authors.affiliation: School of Nursing, Nanjing Medical University, Jiangsu, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Medical Affairs, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Jiangsu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Jiangsu, China.
authors.forename: Rong-bin
authors.initials: RB
authors.lastname: Yu
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yue
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006526:Hepatitis C / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol