title: Serum levels of soluble vascular cell adhesion molecules may correlate with the severity of dengue virus-1 infection in adults.
abstract: The damage of vascular endothelial cells has been speculated to be involved in the pathogenesis of dengue virus (DENV) infection. However, little is known about the role of soluble vascular cell adhesion molecule-1 (sVCAM-1) in predicting the severity of dengue infection in adults. In this study, 51 adults with DENV-1 infection (21 with severe dengue and 30 with dengue fever (DF) were included, and their serum levels of sVCAM-1 and other parameters were determined. The results indicated that the levels of sVCAM-1 were elevated on days 1-3 to 16.75 (11.55-34.74) ng/mL in the severe dengue patients. These levels increased rapidly to peak values of 43.53 (37.15-47.02) ng/mL on days 10-12 and then declined; however, the values were maintained at a high level (38.07 (26.06-39.63) ng/mL). Other parameters, including reduced platelet (PLT) counts, neutrophil (NEU) counts and increased levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and creatine kinase (CK), were also observed in the severe dengue group but not in the DF group. The levels of cytokines, such as interleukin (IL)-6, IL-10, interferon γ (IFNγ), and tumor necrosis factor α (TNF-α), were transiently increased in the severe dengue patients. Among the aforementioned parameters, only sVCAM-1 levels were significantly elevated earlier and more persistently in the severe dengue patients than in the DF patients. sVCAM-1 positively correlated with the levels of ALT, AST, LDH, TNF-α, and IL-6 and negatively correlated with the levels of PLT, NEU, and viremia. Notably, the high levels of sVCAM-1 were closely associated with the severe dengue patients. In conclusion, sVCAM-1 may be a superior indicator for monitoring the severity of dengue.
authors.affiliation: Institute of Infectious Diseases, Guangzhou 8th People's Hospital, Guangzhou Medical University , Guangzhou 510060, Guangdong Province, China.
authors.forename: Baolin
authors.initials: B
authors.lastname: Liao
authors.affiliation: Institute of Infectious Diseases, Guangzhou 8th People's Hospital, Guangzhou Medical University , Guangzhou 510060, Guangdong Province, China.
authors.forename: Yangbo
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Institute of Infectious Diseases, Guangzhou 8th People's Hospital, Guangzhou Medical University , Guangzhou 510060, Guangdong Province, China.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Hu
authors.affiliation: Department of Infectious Diseases, The Third People's Hospital of Huizhou , Huizhou 516002, Guangdong Province, China.
authors.forename: Weize
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Institute of Infectious Diseases, Guangzhou 8th People's Hospital, Guangzhou Medical University , Guangzhou 510060, Guangdong Province, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Yao
authors.affiliation: Institute of Infectious Diseases, Guangzhou 8th People's Hospital, Guangzhou Medical University , Guangzhou 510060, Guangdong Province, China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Hong
authors.affiliation: Institute of Infectious Diseases, Guangzhou 8th People's Hospital, Guangzhou Medical University , Guangzhou 510060, Guangdong Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Infectious Diseases, Guangzhou 8th People's Hospital, Guangzhou Medical University , Guangzhou 510060, Guangdong Province, China.
authors.forename: Xiayi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Infectious Diseases, Guangzhou 8th People's Hospital, Guangzhou Medical University , Guangzhou 510060, Guangdong Province, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Tang
authors.affiliation: Institute of Infectious Diseases, Guangzhou 8th People's Hospital, Guangzhou Medical University , Guangzhou 510060, Guangdong Province, China.
authors.forename: Fuchun
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000328:Adult; D017677:Age Distribution; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood; D003715:Dengue / Q000097:blood*; D003716:Dengue Virus / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012367:RNA, Viral / Q000097:blood; D012307:Risk Factors; D012720:Severity of Illness Index; D012744:Sex Ratio; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*; D014766:Viremia / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D012367:RNA, Viral; D019010:Vascular Cell Adhesion Molecule-1
keywords: cytokines; dengue virus; sVCAM-1; severe dengue; vascular endothelial cells