title: Nanoceria: a Potential Therapeutic for Dry AMD.
abstract: Age-related macular degeneration (AMD) is the leading cause of blinding diseases. The "dry" form of AMD is the most common form of AMD. In contrast to the treatable neovascular (wet) AMD, no effective treatment is available for dry AMD. In this review, we summarize the animal models and therapeutic strategies for dry AMD. The novel candidates as potential treatment targets and the potential effectiveness of nanoceria as a treatment of dry AMD are also discussed.
authors.affiliation: Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd, 73104, Oklahoma City, OK, USA. xue-cai@ouhsc.edu.
authors.forename: Xue
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd, 73104, Oklahoma City, OK, USA. james-mcginnis@ouhsc.edu.|Department of Ophthalmology, Dean McGee Eye Institute, Department of Cell Biology, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, 73104, Oklahoma City, OK, USA. james-mcginnis@ouhsc.edu.
authors.forename: James F
authors.initials: JF
authors.lastname: McGinnis
mesh_terms: D000818:Animals; D002563:Cerium / Q000627:therapeutic use*; D004195:Disease Models, Animal; D057092:Geographic Atrophy / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D051379:Mice; D051381:Rats; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors* / Q000378:metabolism; D057135:Wet Macular Degeneration / Q000188:drug therapy / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D002563:Cerium; C030583:ceric oxide
keywords: Animal models; Drusen; Dry AMD; Nanoceria; RPE; Therapeutic strategies