title: Maternal serum atrial natriuretic peptide (ANP) and brain-type natriuretic peptide (BNP) levels in gestational diabetes mellitus.
abstract: OBJECTIVE
  The aim of the study is to evaluate maternal serum atrial natriuretic peptide (ANP) and brain-type natriuretic peptide (BNP) levels in patients with getational diabetes mellitus compared with a control group.
  
  
  METHODS
  We have measured maternal serum ANP and BNP levels in 35 otherwise healthy and 45 gestational diabetic women between gestational week 24 and 28 referred to our unit in a cross-sectional study. Independent samples t-test or the Mann-Whitney U-test was used for comparison of two groups where appropriate.
  
  
  RESULTS
  Mean maternal serum homeostasis model assessment of insulin resistance (HOMA-IR), HbA1c, fasting glucose and insulin levels in gestational diabetes mellitus (GDM) group were significantly higher than the control group (p < 0.01). Mean maternal serum ANP and BNP levels of women with GDM were significantly lower than the control group (12.9 ± 9.9 versus 34.8 ± 16.9 pg/ml, p < 0.001; 416.6 ± 209.7 versus 629.7 ± 162.2 mg/dl, p < 0.001, respectively). Maternal serum ANP and BNP levels were negatively correlated with insulin levels, HbA1c and HOMA-IR values (p < 0.05).
  
  
  CONCLUSIONS
  Maternal serum ANP and BNP levels are significantly lower in patients with GDM. These biomarkers might be valuable in clinical setting for identifying high-risk women for developing diabetes during pregnancy.
authors.affiliation: a Department of Obstetrics and Gynecology , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey .
authors.forename: Mehmet Aytac
authors.initials: MA
authors.lastname: Yuksel
authors.affiliation: a Department of Obstetrics and Gynecology , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey .
authors.forename: Ebru
authors.initials: E
authors.lastname: Alici Davutoglu
authors.affiliation: b Department of Obstetrics and Gynecology , Istanbul Okmeydani Research and Training Hospital , Istanbul , Turkey , and.
authors.forename: Ilkbal
authors.initials: I
authors.lastname: Temel Yuksel
authors.affiliation: c Department of Biochemistry , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Kucur
authors.affiliation: c Department of Biochemistry , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ekmekci
authors.affiliation: c Department of Biochemistry , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Balci Ekmekci
authors.affiliation: a Department of Obstetrics and Gynecology , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey .
authors.forename: Sezin
authors.initials: S
authors.lastname: Uludag
authors.affiliation: a Department of Obstetrics and Gynecology , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey .
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Uludag
authors.affiliation: a Department of Obstetrics and Gynecology , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey .
authors.forename: Riza
authors.initials: R
authors.lastname: Madazli
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor
keywords: Atrial natriuretic peptide; brain-type natriuretic peptide; gestational diabetes mellitus