title: Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology.
abstract: Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects.
authors.affiliation: Laboratory of Respiratory Biology, Department of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors.forename: Jaime M
authors.initials: JM
authors.lastname: Cyphert
authors.affiliation: Laboratory of Respiratory Biology, Department of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors.forename: Carol S
authors.initials: CS
authors.lastname: Trempus
authors.affiliation: Laboratory of Respiratory Biology, Department of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors.forename: Stavros
authors.initials: S
authors.lastname: Garantziotis