title: Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy.
abstract: An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical microinflammation with influx of macrophages and consequent generation of myriad proinflammatory cytokines and ensuing kidney damage. Among various proinflammatory cytokines, tumor necrosis factor-α (TNF-α) has attracted the most attention, since it amplifies the inflammatory network of cytokines, leading to worsening of the progression of diabetic nephropathy. The article by Awad et al. examines the role of TNF-α in the pathogenesis of experimental diabetic nephropathy.
authors.affiliation: Department of Nephrology and Renal Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Pathology, Northwestern University, Chicago, Illinois, USA.|Department of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Yashpal S
authors.initials: YS
authors.lastname: Kanwar
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D018836:Inflammation Mediators; D014409:Tumor Necrosis Factor-alpha