title: Association of the COL1A1 gene polymorphisms in Mexican postmenopausal women with fracture or with low bone mineral density at the hip.
abstract: OBJECTIVE
  Osteoporosis leads to high fracture risk and evidence suggests that genetic factors play an important role in this disease. The aim was to evaluate the association of two polymorphisms (-1997G/T, +1245G/T) in the collagen type1 alpha 1 gene (COL1A1) with fracture or with low bone mineral density (BMD) at the hip in postmenopausal Mexican women.
  
  
  METHODS
  BMD was determined by bone densitometry and the risk factors were collected with a questionnaire. Genotyping was performed by real-time PCR.
  
  
  RESULTS
  The polymorphisms were in Hardy-Weinberg equilibrium. The -1997G/+1245T haplotype showed, after adjustment for confounders, a fourfold increased risk of hip fracture [OR 4.32; p = 0.041 (95 % CI 1.07-17.43)]; while in the women with low BMD at the hip, the risk was increased threefold [OR 3.36; p = 0.022 (95 % CI 1.20-9.40)].
  
  
  CONCLUSIONS
  The results support the association of COL1A1 gene polymorphisms with fracture and with low BMD at the hip in Mexican population.
authors.affiliation: Departamento de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico.
authors.forename: Edith
authors.initials: E
authors.lastname: Falcón-Ramírez
authors.affiliation: Departamento de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico.
authors.forename: Alberto
authors.initials: A
authors.lastname: Hidalgo-Bravo
authors.affiliation: Departamento de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico.
authors.forename: Blanca Alicia
authors.initials: BA
authors.lastname: Barredo-Prieto
authors.affiliation: Servicio de Traumatología, Instituto Nacional de Rehabilitación, Mexico City, Mexico.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Pineda-Gómez
authors.affiliation: Departamento de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico. efalcon2005@gmail.com.
authors.forename: Margarita
authors.initials: M
authors.lastname: Valdés-Flores
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000235:genetics; D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006620:Hip Fractures / Q000235:genetics*; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics; D011110:Polymorphism, Genetic; D017698:Postmenopause
chemical_list: D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain
keywords: COL1A1 haplotypes; Hip fracture; Osteoporosis; Polymorphisms