title: Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25.
abstract: Interleukin-23 (IL-23) is a conventional proinflammatory cytokine that plays a role in tumor progression by inducing inflammation in the tumor microenvironment. However, the role of IL-23 in thyroid cancer migration and invasion remains unclear. In the present study, we observed that the treatment with IL-23, induced migration and invasion in human thyroid cancer cells. Additional data demonstrate that SOCS4 negatively regulates IL-23-mediated migration and invasion. On investigating the mechanisms involved in IL-23 mediated migration and invasion, we observed that miR-25 promotes the migration and invasion of thyroid cancer cells by directly binding to the 3'-UTR of SOCS4 that leads to the inhibition of SOCS4. In addition, we also demonstrated that IL-23 increases miR-25 expression levels, and overexpressed miR-25 is involved in IL-23-associated SOCS4 inhibition and cell migration and invasion. Together, our data suggest that IL-23 induces migration and invasion in thyroid cancer cells by mediating the miR-25/SOCS4 signaling pathway.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Remin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, the People's Republic of China.
authors.forename: Zhidan
authors.initials: Z
authors.lastname: Mei
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Remin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, the People's Republic of China.
authors.forename: Shiming
authors.initials: S
authors.lastname: Chen
authors.affiliation: Research Institute of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, the People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Research Institute of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, the People's Republic of China.
authors.forename: Bokui
authors.initials: B
authors.lastname: Xiao
authors.affiliation: Research Institute of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, the People's Republic of China.
authors.forename: Fen
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Remin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, the People's Republic of China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Remin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, the People's Republic of China; Research Institute of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, the People's Republic of China.
authors.forename: Zezhang
authors.initials: Z
authors.lastname: Tao
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D002465:Cell Movement / Q000187:drug effects; D004273:DNA, Neoplasm / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology; D006801:Humans; D053759:Interleukin-23 / Q000494:pharmacology*; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D034741:RNA, Small Interfering / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D013964:Thyroid Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured; D015854:Up-Regulation
chemical_list: D020413:3' Untranslated Regions; D004273:DNA, Neoplasm; D053759:Interleukin-23; C543351:MIRN25 microRNA, human; D035683:MicroRNAs; D034741:RNA, Small Interfering; C473084:SOCS4 protein, human; D050826:Suppressor of Cytokine Signaling Proteins