title: Emerging roles of the Th17/IL-17-axis in glomerulonephritis.
abstract: Different T cell subsets have been implicated in the pathogenesis of glomerulonephritis. Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T cells (Th17 cells) to be involved in the renal inflammatory cascade associated with glomerulonephritis. In this review we outline different forms of glomerulonephritis and the contribution of the Th17/IL-17-axis in mediating the downstream effects and pathology associated with the disease. Learning more about the Th17/IL-17-axis can help to develop promising therapeutic strategy for the treatment of various forms of glomerulonephritis.
authors.affiliation: Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: Kritika
authors.initials: K
authors.lastname: Ramani
authors.affiliation: Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: psb13@pitt.edu.
authors.forename: Partha S
authors.initials: PS
authors.lastname: Biswas
mesh_terms: D000818:Animals; D005921:Glomerulonephritis / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D020381:Interleukin-17 / Q000276:immunology* / Q000378:metabolism; D007668:Kidney / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018448:Models, Immunological; D053722:Receptors, Interleukin-17 / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: C508717:IL17A protein, human; D018836:Inflammation Mediators; D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: Glomerulonephritis; IL-17; T-helper 17