title: Effect of Polydextrose Intake on Constipation in Japanese Dialysis Patients: A Triple-Blind, Randomized, Controlled Trial.
abstract: The objective of the present study was to evaluate bowel habits induced by ingestion of 10 g polydextrose (PDX) fed to Japanese hemodialysis (HD) patients. This was a randomized, placebo-controlled, triple-blind, parallel-group controlled, 8-wk study. A total of 50 HD outpatients capable of self-management (51-79 y of age) were recruited at H Clinic, Japan. Inclusion criteria for participation in the study were ingestion of one or more laxative tablets for more than 3 mo and having received HD for more than 6 mo. The participants were randomly assigned to 2 groups: A (0 g polydextrose/d; control), B (10 g polydextrose/d; PDX). The primary outcome measure was stool frequency. Secondary outcomes were stool consistency, abdominal pain, intestinal bloating and clinical biochemistry indexes. PDX had no significant effect on blood biochemistry indexes. The PDX group showed significant improvements in bowel function (stool frequency increased from 3.0 times per week to 7.5 times per week) and reported no laxation problems (abdominal distention, cramps, and diarrhea) (p<0.01). Regular consumption of the PDX products increased dietary fiber intake to recommended levels and improved bowel habits.
authors.affiliation: Medical Corporations Hidaka Rehabilitation Hospital.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Shimada
authors.forename: Nobuo
authors.initials: N
authors.lastname: Nagano
authors.forename: Saori
authors.initials: S
authors.lastname: Goto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ito
authors.forename: Takaaki
authors.initials: T
authors.lastname: Tsutsui
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ando
authors.forename: Hiroharu
authors.initials: H
authors.lastname: Kamioka
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ogawa
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced; D000368:Aged; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003672:Defecation / Q000187:drug effects; D004043:Dietary Fiber / Q000627:therapeutic use*; D005243:Feces; D005260:Female; D005503:Food Additives / Q000627:therapeutic use; D005936:Glucans / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D054368:Laxatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012107:Research Design
chemical_list: D004043:Dietary Fiber; D005503:Food Additives; D005936:Glucans; D054368:Laxatives; C033375:polydextrose