title: Spreading the word: non-autonomous effects of apoptosis during development, regeneration and disease.
abstract: Apoptosis, in contrast to other forms of cell death such as necrosis, was originally regarded as a 'silent' mechanism of cell elimination designed to degrade the contents of doomed cells. However, during the past decade it has become clear that apoptotic cells can produce diverse signals that have a profound impact on neighboring cells and tissues. For example, apoptotic cells can release factors that influence the proliferation and survival of adjacent tissues. Apoptosis can also affect tissue movement and morphogenesis by modifying tissue tension in surrounding cells. As we review here, these findings reveal unexpected roles for apoptosis in tissue remodeling during development, as well as in regeneration and cancer.
authors.affiliation: Strang Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Pérez-Garijo
authors.affiliation: Strang Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA steller@rockefeller.edu.
authors.forename: Hermann
authors.initials: H
authors.lastname: Steller
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001343:Autophagy / Q000502:physiology; D048788:Growth and Development / Q000502:physiology*; D006801:Humans; D009024:Morphogenesis / Q000502:physiology*; D009336:Necrosis / Q000503:physiopathology; D009369:Neoplasms / Q000503:physiopathology*; D012038:Regeneration / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
keywords: Apoptosis; Morphogenesis; Signaling; Silent mechanism of cell elimination; Tissue remodeling