title: Innate Lymphoid Cells in Cancer.
abstract: The world of lymphocytes has recently expanded. A group of cells, innate lymphoid cells (ILC), has been defined. It includes lymphoid cells that have been known for decades, such as natural killer (NK) cells and lymphoid tissue-inducer (LTi) cells. NK cells recognize a vast array of tumor cells, which they help to eliminate through cytotoxicity and the production of cytokines, such as IFNγ. Advances in our understanding of NK-cell biology have led to a growing interest in the clinical manipulation of these cells in cancer. The other ILCs are found mostly in the mucosae and mucosal-associated lymphoid tissues, where they rapidly initiate immune responses to pathogens without the need for specific sensitization. Here, we outline the basic features of ILCs and review the role of ILCs other than NK cells in cancer. Much of the role of these ILCs in cancer remains unknown, but several findings should lead to further efforts to dissect the contribution of different ILC subsets to the promotion, maintenance, or elimination of tumors at various anatomic sites. This will require the development of standardized reagents and protocols for monitoring the presence and function of ILCs in human blood and tissue samples.
authors.affiliation: Department of Pediatric Hematology and Oncology, Timone Enfants Hospital and Aix Marseille University, Marseille, France.
authors.forename: Blandine
authors.initials: B
authors.lastname: Vallentin
authors.affiliation: Department of Pediatric Hematology and Oncology, Timone Enfants Hospital and Aix Marseille University, Marseille, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Barlogis
authors.affiliation: Immunologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Piperoglou
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Cypowyj
authors.affiliation: BD Biosciences, Le Pont-de-Claix, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Zucchini
authors.affiliation: BD Biosciences, Le Pont-de-Claix, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Chéné
authors.affiliation: BD Biosciences, Le Pont-de-Claix, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Navarro
authors.affiliation: Immunologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Farnarier
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France. Immunologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France. vivier@ciml.univ-mrs.fr vely@ciml.univ-mrs.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France. Immunologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France. vivier@ciml.univ-mrs.fr vely@ciml.univ-mrs.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Vély
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D010641:Phenotype