title: RISK OF RETINAL VEIN OCCLUSION WITH CENTRAL SEROUS CHORIORETINOPATHY.
abstract: OBJECTIVE
  To investigate the risk of retinal vein occlusion (RVO) after central serous chorioretinopathy (CSCR).
  
  
  METHODS
  The study included 2882 CSCR patients and 17,292 control patients matched by age, sex, number of visits to an ophthalmologist, diabetes mellitus, hypertension, and hyperlipidemia from January 2001 to December 2010 from the Taiwan Longitudinal Health Insurance Database 2000. Information for each patient was collected until December 2011. Cox proportional hazard regression analysis was used to obtain the adjusted hazard ratio for RVO. The RVO-free survival rate was calculated using Kaplan-Meier analysis.
  
  
  RESULTS
  There was a significantly higher risk of RVO in CSCR patients than in controls (incidence rate ratio = 3.07, 95% confidence interval = 1.86-5.07). After adjustment for potential confounders, the adjusted hazard ratio for developing RVO in the CSCR patients was 3.15 times higher than that of the controls (adjusted hazard ratio = 3.15, 95% confidence interval = 1.91-5.21).
  
  
  CONCLUSIONS
  Central serous chorioretinopathy increases the risk of RVO. For CSCR patients, the authors recommend thorough retinal vessel evaluation, regular follow-up, and education regarding RVO for patients with CSCR.
authors.affiliation: *Departments of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan; †Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan; ‡Department of Education, University of Taipei, Taipei, Taiwan; §Medical Research, Chi Mei Medical Center, Tainan, Taiwan; ¶Department of Hospital and Health-Care Administration, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan; **Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan; ††Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan, Taiwan; and ‡‡Graduate Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yuh-Shin
authors.initials: YS
authors.lastname: Chang
authors.forename: Chun
authors.initials: C
authors.lastname: Chang
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Weng
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
authors.forename: Ren-Long
authors.initials: RL
authors.lastname: Jan
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000150:complications*; D016208:Databases, Factual / Q000706:statistics & numerical data; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D012170:Retinal Vein Occlusion / Q000453:epidemiology* / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013624:Taiwan