title: Zinc Triflate Catalyzed C-Benzylation: Chemo- and Regioselective Route to Amido Substituted Diaryl and Arylheteroarylmethanes.
abstract: An unprecedented zinc triflate catalyzed selective C-benzylation of anilides and heteroaryl amides with benzyl chlorides having electron-donating group at para-position is reported. The protocol offers moderate to high yield of para-amido substituted diaryl and arylheteroarylmethanes, uses cheap and easily available benzyl chlorides as the benzylating agent, catalytic amount of zinc triflate, and takes place under ambient conditions. Aminodiarylmethane derivatives can be obtained by hydrolysis of the corresponding amides. The methodology has also been applied for preparing dimethoxydiarylmethanes in good yields, which are the key precursors for synthesis of phenolic natural products.
authors.affiliation: Daiichi Sankyo India Pharma Pvt. Ltd. , Sector-18, Gurgaon, Haryana 122015, India.
authors.forename: Mahesh Subhashrao
authors.initials: MS
authors.lastname: Deshmukh
authors.affiliation: Department of Chemistry, Indian Institute of Technology , New Delhi 110016, India.
authors.forename: Ananya
authors.initials: A
authors.lastname: Srivastava
authors.affiliation: Daiichi Sankyo India Pharma Pvt. Ltd. , Sector-18, Gurgaon, Haryana 122015, India.
authors.forename: Biswajit
authors.initials: B
authors.lastname: Das
authors.affiliation: Department of Chemistry, Indian Institute of Technology , New Delhi 110016, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Jain