title: Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism.
abstract: Genomic instability and altered metabolism are key features of most cancers. Recent studies suggest that metabolic reprogramming is part of a systematic response to cellular DNA damage. Thus, defining the molecules that fine-tune metabolism in response to DNA damage will enhance our understanding of molecular mechanisms of tumorigenesis and have profound implications for the development of strategies for cancer therapy. Sirtuins have been established as critical regulators in cellular homeostasis and physiology. Here, we review the emerging data revealing a pivotal function of sirtuins in genome maintenance and cell metabolism, and highlight current advances about the phenotypic consequences of defects in these critical regulators in tumorigenesis. While many questions should be addressed about the regulation and context-dependent functions of sirtuins, it appears clear that sirtuins may provide a promising, exciting new avenue for cancer therapy.
authors.affiliation: Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.|Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.
authors.forename: Seung Min
authors.initials: SM
authors.lastname: Jeong
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
authors.forename: Marcia C
authors.initials: MC
authors.lastname: Haigis
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D002467:Cell Nucleus / Q000201:enzymology; D004734:Energy Metabolism; D042822:Genomic Instability; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D037761:Sirtuins / Q000502:physiology*
chemical_list: D037761:Sirtuins
keywords: cancer; genomic stability; metabolism; sirtuins