title: Basal Ganglia Activity Mirrors a Benefit of Action and Reward on Long-Lasting Event Memory.
abstract: The expectation of reward is known to enhance a consolidation of long-term memory for events. We tested whether this effect is driven by positive valence or action requirements tied to expected reward. Using a functional magnetic resonance imaging (fMRI) paradigm in young adults, novel images predicted gain or loss outcomes, which in turn were either obtained or avoided by action or inaction. After 24 h, memory for these images reflected a benefit of action as well as a congruence of action requirements and valence, namely, action for reward and inaction for avoidance. fMRI responses in the hippocampus, a region known to be critical for long-term memory function, reflected the anticipation of inaction. In contrast, activity in the putamen mirrored the congruence of action requirement and valence, whereas other basal ganglia regions mirrored overall action benefits on long-lasting memory. The findings indicate a novel type of functional division between the hippocampus and the basal ganglia in the motivational regulation of long-term memory consolidation, which favors remembering events that are worth acting for.
authors.affiliation: Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK.
authors.forename: Raphael
authors.initials: R
authors.lastname: Koster
authors.affiliation: Aging Research Centre, Karolinska Institute, SE-11330 Stockholm, Sweden Max Planck Centre for Computational Psychiatry and Ageing, University College London, London, UK.
authors.forename: Marc
authors.initials: M
authors.lastname: Guitart-Masip
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK Max Planck Centre for Computational Psychiatry and Ageing, University College London, London, UK.
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Dolan
authors.affiliation: Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK Otto von Guericke University Magdeburg, Institute of Cognitive Neurology and Dementia Research, D-39120 Magdeburg, Germany German Center for Neurodegenerative Diseases, D-39120 Magdeburg, Germany.
authors.forename: Emrah
authors.initials: E
authors.lastname: Düzel
mesh_terms: D000293:Adolescent; D000328:Adult; D001479:Basal Ganglia / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D057567:Memory, Long-Term / Q000502:physiology*; D009042:Motivation / Q000502:physiology; D009043:Motor Activity; D011597:Psychomotor Performance / Q000502:physiology*; D012201:Reward; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
keywords: Pavlovian; decision-making; fMRI; hippocampus