title: Impact of intraprocedural thrombotic events on short- and long-term outcomes following percutaneous coronary intervention. Evidence from a meta-analysis.
abstract: BACKGROUND
  Data regarding the effects of intraprocedural thrombotic events (IPTE) are scarce. Hence we aim to perform a meta-analysis to examine the outcomes of IPTE compared to non-IPTE during PCI.
  
  
  METHODS
  We performed a literature search of all published full-length articles of studies that reported data on patients with IPTE compared with non-IPTE during PCI. We calculated odd ratios via random effects model.
  
  
  RESULTS
  A total of 26,697 patients, of which 1572 patients had IPTE, were included in this analysis. In-hospital, IPTE was associated with higher mortality (odds ratio (OR) 5.36, 95% confidence interval (CI) [2.31, 12.41]; p<0.0001), myocardial infarction (MI) and major bleeding compared to non-IPTE. At 30 days, IPTE was also associated with higher mortality (OR 4.57, 95% CI [2.43, 8.60]; p<0.0001), MI, repeat revascularization, stent thrombosis and major bleeding compared to non-IPTE group. IPTE was also associated with higher long-term mortality (OR 2.19, 95% CI [1.35, 3.53]; p=0.001). Among IPTE patients, intraprocedural stent thrombosis was associated with greater odds of MI compared to both no reflow and distal embolization events.
  
  
  CONCLUSIONS
  IPTE during PCI is associated with more adverse ischemic events, including mortality, during the index hospitalization, at 30 days and long-term.
authors.affiliation: Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: ramez.nairooz@gmail.com.
authors.forename: Ramez
authors.initials: R
authors.lastname: Nairooz
authors.affiliation: Division of Cardiology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA.
authors.forename: Dmitriy N
authors.initials: DN
authors.lastname: Feldman
authors.affiliation: Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Yogita
authors.initials: Y
authors.lastname: Rochlani
authors.affiliation: Division of Cardiology, New York Medical College-Westchester Medical Center, Valhalla, NY, USA.
authors.forename: Wilbert S
authors.initials: WS
authors.lastname: Aronow
authors.affiliation: Division of Cardiovascular medicine, University of Utah, Salt Lake City, UT, USA.
authors.forename: Partha
authors.initials: P
authors.lastname: Sardar
authors.affiliation: Department of Cardiology, Texas Tech University Health Sciences Center, El Paso, TX, USA.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Mukherjee
authors.affiliation: Department of Cardiology, Winthrop University Hospital, Mineola, NY, USA.
authors.forename: Srihari S
authors.initials: SS
authors.lastname: Naidu
authors.affiliation: Division of Cardiology, University of California, Irvine Medical Center, Orange, CA, USA.
authors.forename: Pranav
authors.initials: P
authors.lastname: Patel
mesh_terms: D054058:Acute Coronary Syndrome / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007431:Intraoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data*; D015607:Stents / Q000009:adverse effects; D013927:Thrombosis / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D016896:Treatment Outcome
keywords: Distal embolization; Intraprocedural thrombotic events; No reflow; PCI