title: Copper-catalyzed arylation of biguanide derivatives via C-N cross-coupling reactions.
abstract: An efficient copper-catalyzed cross-coupling reaction of biguanide hydrochloride derivatives with both aryl iodides and bromides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl halides containing functionalities such as nitriles, sulfonamides, ethers, and halogens. Alkyl and cyclic substituted biguanidines were also well tolerated.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China. chenzhang@zju.edu.cn.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.forename: Ai-Qing
authors.initials: AQ
authors.lastname: Bao
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.forename: Shunna
authors.initials: S
authors.lastname: Guo
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Jun-Zhi
authors.initials: JZ
authors.lastname: Xu
authors.forename: Rihao
authors.initials: R
authors.lastname: Zhang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Cui