title: Localized intestinal perforations as a potential complication of brain hypothermic therapy for perinatal asphyxia.
abstract: Brain hypothermic therapy (BHT) is becoming a frequently used standard of care for perinatal asphyxia. Although cardiovascular side effects, coagulation disorders, renal impairment, electrolyte abnormalities, impaired liver function, opportunistic infections, and skin lesions are well-known adverse effects of BHT in newborns, little information is available on the clinical features of intestinal perforation-related BHT. We herein report a case of therapeutic brain cooling for perinatal asphyxia complicated by localized intestinal perforation. In practice, the neonatologist should be aware that intestinal perforation in an infant with perinatal asphyxia is possible, particularly following BHT.
authors.affiliation: a Department of Pediatrics and.
authors.forename: Naoto
authors.initials: N
authors.lastname: Nishizaki
authors.affiliation: a Department of Pediatrics and.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Maiguma
authors.affiliation: a Department of Pediatrics and.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Obinata
authors.affiliation: b Department of Pediatric Surgery , Juntendo University Urayasu Hospital , Chiba , Japan , and.
authors.forename: Tadaharu
authors.initials: T
authors.lastname: Okazaki
authors.affiliation: c Department of Pediatrics , Juntendo University School of Medicine , Tokyo , Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications / Q000628:therapy*; D001921:Brain / Q000503:physiopathology; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology* / Q000628:therapy; D007231:Infant, Newborn; D007416:Intestinal Perforation / Q000209:etiology*; D008297:Male; D011247:Pregnancy
keywords: Brain hypothermic therapy; hypoxic-ischemic encephalopathy; localized intestinal perforation; perinatal asphyxia