title: Two unresolved problems facing models of the Self-Nonself discrimination.
abstract: Although the Associative (linked) Recognition of Antigen (ARA) model for a Self (S)-Nonself (NS) discrimination, now over 50 years old, is built on a solid conceptual and experimental base, two unsettled questions remain. In examining these questions, unanticipated aspects of the ARA Model itself had to be reconsidered. This essay spells out these problems and suggests possible solutions.
authors.affiliation: Conceptual Immunology Group, The Salk Institute, 10010 N. Torrey Pines Rd., La Jolla, CA 92037-1099, USA. Electronic address: cohn@salk.edu.
authors.forename: Melvin
authors.initials: M
authors.lastname: Cohn
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism
chemical_list: D001324:Autoantigens; D011948:Receptors, Antigen, T-Cell
keywords: Antigen presenting cell; Autoimmunity; T cell receptor polyreactivity; T cell receptor signaling; Tolerance