title: Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser.
abstract: A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
authors.forename: Jordan
authors.initials: J
authors.lastname: Atchison
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
authors.forename: Sukanta
authors.initials: S
authors.lastname: Kamila
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
authors.forename: Conor
authors.initials: C
authors.lastname: McEwan
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
authors.forename: Heather
authors.initials: H
authors.lastname: Nesbitt
authors.affiliation: Engineering Research Institute, University of Ulster, Jordanstown, Northern Ireland BT37 0QB, UK.
authors.forename: James
authors.initials: J
authors.lastname: Davis
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
authors.forename: Colin
authors.initials: C
authors.lastname: Fowley
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
authors.forename: Bridgeen
authors.initials: B
authors.lastname: Callan
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: McHale
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
authors.forename: John F
authors.initials: JF
authors.lastname: Callan
mesh_terms: D000818:Animals; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D016513:Mice, SCID; D010190:Pancreatic Neoplasms / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species