title: The expression and significance of XIAP and C-jun on Condyloma acuminatum.
abstract: Objective of the study was to investigate the expression and significance of XIAP and c-jun in Condyloma acuminatum. The immunohistochemistry SABC method was adopted to detect the expression of XIAP and c-jun in Condyloma acuminatum. The positive expression rate of XIAP and c-jun in Condyloma acuminatum was 80% (32/40) and 90% (36/40) separately and the intensity of expression was usually ++ ~ +++. While in control group, the positive expression rate of XIAP and c-jun was 27.8% (5/18) and 16.7 % (3/18) separately, and the intensity of expression was - ~ ++. There was statistical significance of the positive expression rate and the expression intensity of XIAP and c-jun between the two groups (P<0.05). Besides, the positive correlation existed between expression of XIAP and c-jun (r=0.306 P<0.01). The over-expression of XIAP and c-jun in Condyloma acuminatum may be associated with the growth of Condyloma acuminatum.
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
authors.forename: Guang-wen
authors.initials: GW
authors.lastname: Yin
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
authors.forename: Yun-hui
authors.initials: YH
authors.lastname: Huang
authors.forename: Fei-juan
authors.initials: FJ
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D003218:Condylomata Acuminata / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016755:Proto-Oncogene Proteins c-jun / Q000032:analysis*; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000032:analysis*
chemical_list: D016755:Proto-Oncogene Proteins c-jun; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human