title: Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats.
abstract: BACKGROUND
  Cisplatin (CP) is a chemotherapy drug and nephrotoxicity is considered as its major side effect. Aerobic exercise is well known as an approach to reduce the side effects of many drugs.
  
  
  OBJECTIVE
  This study was designed to determine the protective role of aerobic exercise against CP-induced nephrotoxicity.
  
  
  METHODS
  Thirty male Wistar rats were randomly divided into four groups. Group I had aerobic exercise on a treadmill one hour per day and five days per week for eight weeks. Then, the exercise protocol was continued for another week, but during this week, the animals also received CP (2.5 mg/kg/day; ip). Group II underwent the same protocol as group I without exercise in the last week during the CP therapy. Groups III and IV were assigned as positive and negative control groups, and were treated with CP and saline without exercise, respectively. Finally, the animals were sacrificed for the biochemical measurement and tissue histopathology investigation.
  
  
  RESULTS
  CP alone without exercise increased serum levels of blood urea nitrogen (BUN), creatinine (Cr), and malondialdehyde (MDA); and kidney nitrite level, while treadmill exercise in group I significantly ameliorated these parameters (P < 0.05). Kidney and serum levels of MDA and nitrite did not alter significantly. Also, the severity of kidney tissue damage decreased significantly in groups I and II (P < 0.05).
  
  
  CONCLUSIONS
  Aerobic exercise may reduce CP-induced nephrotoxicity with a favorable effect on renal function by increasing activation of antioxidant system.
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Physical Education, Faculty of Physical Education, Isfahan University, Isfahan, IR Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Zeynali
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Isfahan -MN Institute of Basic and Applied Sciences Research, Isfahan, IR Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nematbakhsh
authors.affiliation: Department of Physical Education, Faculty of Physical Education, Isfahan University, Isfahan, IR Iran.
authors.forename: Hossain
authors.initials: H
authors.lastname: Mojtahedi
authors.affiliation: Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Aliasghar
authors.initials: A
authors.lastname: Poorshahnazari
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Talebi
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pezeshki
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Safoora
authors.initials: S
authors.lastname: Mazaheri
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Moslemi
keywords: Cisplatin; Exercise; Nephrotoxicity; Rats