title: Regenerative medicine: Hepatic progenitor cells up their game in the therapeutic stakes.
abstract: Bipotential hepatic progenitor cells (HPCs) are recognized as making modest contributions to hepatocyte regeneration, though never credited with major liver repopulation. A new study in mice demonstrates HPCs can make a massive contribution to hepatocyte replacement, suggesting HPCs have the potential to be an effective cell therapy for liver failure.
authors.affiliation: Centre for Tumour Biology, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Alison
authors.affiliation: Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Department of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
authors.forename: Wey-Ran
authors.initials: WR
authors.lastname: Lin
mesh_terms: D000818:Animals; D001652:Bile Ducts / Q000637:transplantation*; D019070:Cell Lineage; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000637:transplantation*; D005260:Female; D022781:Hepatocytes / Q000637:transplantation*; D008099:Liver; D008115:Liver Regeneration; D008297:Male; D033581:Stem Cell Transplantation; D013234:Stem Cells