title: PAX3 and PAX7 as upstream regulators of myogenesis.
abstract: Like other subclasses within the PAX transcription factor family, PAX3 and PAX7 play important roles in the emergence of a number of different tissues during development. PAX3 regulates neural crest and, together with its orthologue PAX7, is also expressed in parts of the central nervous system. In this chapter we will focus on their role in skeletal muscle. Both factors are key regulators of myogenesis where Pax3 plays a major role during early skeletal muscle formation in the embryo while Pax7 predominates during post-natal growth and muscle regeneration in the adult. We review the expression and functions of these factors in the myogenic context. We also discuss mechanistic aspects of PAX3/7 function and modulation of their activity by interaction with other proteins, as well as the post-transcriptional and transcriptional regulation of their expression.
authors.affiliation: Department of Developmental and Stem Cell Biology, CNRS URA 2578, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France. Electronic address: margaret.buckingham@pasteur.fr.
authors.forename: Margaret
authors.initials: M
authors.lastname: Buckingham
authors.affiliation: INSERM U955 IMRB, Team 10, 94000 Creteil, France; UPEC Paris Est-Creteil University, Faculty of Medicine, F-94000 Creteil, France; Etablissement Français du Sang, 94017 Creteil, France; Université Paris Est, Ecole Nationale Veterinaire d'Alfort, 94700 Maison Alfort, France. Electronic address: frederic.relaix@inserm.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Relaix
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D006801:Humans; D024510:Muscle Development / Q000502:physiology*; D000072041:PAX3 Transcription Factor; D051763:PAX7 Transcription Factor / Q000502:physiology*; D051761:Paired Box Transcription Factors / Q000502:physiology
chemical_list: D000072041:PAX3 Transcription Factor; C489409:PAX3 protein, human; D051763:PAX7 Transcription Factor; C497321:PAX7 protein, human; D051761:Paired Box Transcription Factors
keywords: Muscle stem cells; Myogenesis; Pax3; Pax7