title: Remote Control of the Planar Chirality in Peptide-Bound Metallomacrocycles and Dynamic-to-Static Planar Chirality Control Triggered by Solvent-Induced 3(10)-to-α-Helix Transitions.
abstract: The dynamic planar chirality in a peptide-bound Ni(II)-salphen-based macrocycle can be remotely controlled. First, a right-handed (P)-3(10)-helix is induced in the dynamic helical oligopeptides by a chiral amino acid residue far from the macrocyclic framework. The induced planar chirality remains dynamic in chloroform and acetonitrile, but is almost completely locked in fluoroalcohols as a result of the solvent-induced transition of the peptide chains from a 3(10)-helix to a wider α-helix, which freezes the rotation of the pendant peptide units around the macrocycle.
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603 (Japan) http://helix.mol.nagoya-u.ac.jp/
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Mamiya
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603 (Japan) http://helix.mol.nagoya-u.ac.jp/. ousaka@apchem.nagoya-u.ac.jp.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ousaka
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603 (Japan) http://helix.mol.nagoya-u.ac.jp/. yashima@apchem.nagoya-u.ac.jp.
authors.forename: Eiji
authors.initials: E
authors.lastname: Yashima
mesh_terms: D047028:Macrocyclic Compounds / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D047028:Macrocyclic Compounds; D008670:Metals; D010455:Peptides; D012997:Solvents
keywords: chirality; macrocycles; peptides; self-assembly; supramolecular chemistry