title: Chromatin dynamics after DNA damage: The legacy of the access-repair-restore model.
abstract: Eukaryotic genomes are packaged into chromatin, which is the physiological substrate for all DNA transactions, including DNA damage and repair. Chromatin organization imposes major constraints on DNA damage repair and thus undergoes critical rearrangements during the repair process. These rearrangements have been integrated into the "access-repair-restore" (ARR) model, which provides a molecular framework for chromatin dynamics in response to DNA damage. Here, we take a historical perspective on the elaboration of this model and describe the molecular players involved in damaged chromatin reorganization in human cells. In particular, we present our current knowledge of chromatin assembly coupled to DNA damage repair, focusing on the role of histone variants and their dedicated chaperones. Finally, we discuss the impact of chromatin rearrangements after DNA damage on chromatin function and epigenome maintenance.
authors.affiliation: Epigenome Integrity group, UMR 7216 CNRS, Paris Diderot University, Sorbonne Paris Cité, 35 rue Hélène Brion, 75205 Paris cedex 13, France. Electronic address: sophie.polo@univ-paris-diderot.fr.
authors.forename: Sophie E
authors.initials: SE
authors.lastname: Polo
authors.affiliation: Chromatin Dynamics group, UMR 3664 CNRS, Institut Curie Research Center, PSL Research University, 26 rue d'Ulm, 75248 Paris cedex 05, France. Electronic address: genevieve.almouzni@curie.fr.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Almouzni
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000235:genetics; D004249:DNA Damage; D004260:DNA Repair; D056890:Eukaryota / Q000235:genetics / Q000378:metabolism; D006657:Histones; D006801:Humans; D018832:Molecular Chaperones
chemical_list: D006657:Histones; D018832:Molecular Chaperones; D004247:DNA
keywords: Chromatin assembly; DNA damage repair; Epigenome maintenance; Histone chaperones; Histone variants