title: Promising effects of 3rd line cyclophosphamide, adriamycin and vincristine (CAV) and 4th line ifosfamide and carboplatin chemotherapy in refractory small cell lung cancer.
abstract: Third and fourth line chemotherapy agents are not helpful in the setting of extensive stage small cell lung cancer (SCLC). We describe the case of a 43-year-old Korean patient with T4N3M1b extensive stage SCLC who responded remarkably well to treatment and experienced a prolonged progression-free survival (PFS) period following treatment with fourth line ifosfamide and carboplatin after experiencing disease progression with three previous regimens. Additionally, third line cyclophosphamide, doxorubicin (Adriamycin), and vincristine demonstrated long-term PFS periods.
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Sang Ok
authors.initials: SO
authors.lastname: Jung
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea ; Cancer Institute of Chungnam National University Deajeon, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Ju-Ock
authors.initials: JO
authors.lastname: Kim
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Jung
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Hee Sun
authors.initials: HS
authors.lastname: Park
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Moon
authors.affiliation: Department of Nuclear Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea ; Cancer Institute of Chungnam National University Deajeon, Korea.
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Lee
keywords: Cyclophosphamide; ifosfamide; refractory; small cell lung carcinoma