title: Upregulation of integrin expression on monocytes in multiple sclerosis patients treated with natalizumab.
abstract: Natalizumab is a humanized monoclonal antibody against the α4 subunit of VLA-4 integrin that is used to treat conditions such as multiple sclerosis (MS). Although its effects on lymphocytes have been widely described, little is known about its effects on monocytes. Here we described the effects of natalizumab treatment on peripheral blood monocytes from a small cohort of MS patients in terms of relative frequencies and surface integrin (CD49d and CD18) expression. We showed that natalizumab treatment altered the surface integrin expression on monocyte subsets in the peripheral compartment, suggesting a role for them as mediators of natalizumab effects.
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Dallari
authors.affiliation: Department of General Neurology, National Neurological Institute C. Mondino, Pavia, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Franciotta
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Carluccio
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Signorini
authors.affiliation: Department of General Neurology, National Neurological Institute C. Mondino, Pavia, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Gastaldi
authors.affiliation: Department of General Neurology, National Neurological Institute C. Mondino, Pavia, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Colombo
authors.affiliation: Department of General Neurology, National Neurological Institute C. Mondino, Pavia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bergamaschi
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Elia
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Villani
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy; Fondazione Ettore Sansavini, Health Science Foundation, Lugo, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Ferrante
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy. Electronic address: serena.delbue@unimi.it.
authors.forename: Serena
authors.initials: S
authors.lastname: Delbue
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D016023:Integrins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000145:classification / Q000187:drug effects*; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000473:pathology*; D000069442:Natalizumab / Q000494:pharmacology* / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D015703:Antigens, CD; D007155:Immunologic Factors; D016023:Integrins; D000069442:Natalizumab
keywords: Monocytes; Multiple sclerosis; Natalizumab