title: Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells.
abstract: Small-molecule perturbation of biological systems is able to tackle biological problems that are not accessible by classical genetic interference methods. Chemically induced dimerization (CID) has been used as a valuable tool to study various biological processes. Recent years have seen tremendous progress in the development of orthogonal and reversible CID systems. These new systems allow control over protein function with unprecedented precision and spatiotemporal resolution. While the primary application of CID has been on dissecting signal transductions, new emerging approaches have extended the scope of this technique to elucidating membrane and protein trafficking.
authors.affiliation: Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Str. 15, 44227 Dortmund, Germany; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Voß
authors.affiliation: Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Str. 15, 44227 Dortmund, Germany; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Klewer
authors.affiliation: Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Str. 15, 44227 Dortmund, Germany; Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany. Electronic address: yaowen.wu@mpi-dortmund.mpg.de.
authors.forename: Yao-Wen
authors.initials: YW
authors.lastname: Wu
mesh_terms: D000818:Animals; D001671:Biochemistry / Q000379:methods; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D055503:Protein Multimerization; D021381:Protein Transport; D011506:Proteins / Q000032:analysis / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011506:Proteins