title: Cancer-Cell-Specific Nuclear-Targeted Drug Delivery by Dual-Ligand-Modified Mesoporous Silica Nanoparticles.
abstract: Mesoporous silica nanoparticles are modified with dual targeting ligands, i.e., folic acid and dexamethasone, to construct a cancer-cell-specific nuclear-targeted delivery system. The resulting nanocarriers can not only enhance the inhibition efficacy of doxorubicin on Hela cells through active nucleus accumulation but also reduce toxic side effects on noncancer cells though receptor-mediated selective cellular uptake.
authors.affiliation: School of Chemical Engineering, The University of Adelaide, Adelaide, SA, 5005, Australia.
authors.forename: Lin
authors.initials: L
authors.lastname: Xiong
authors.affiliation: School of Chemical Engineering, The University of Adelaide, Adelaide, SA, 5005, Australia.
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.affiliation: Department of Chemistry and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, Quebec City, QC, G1V 0A6, Canada.
authors.forename: Freddy
authors.initials: F
authors.lastname: Kleitz
authors.affiliation: School of Chemical Engineering, The University of Adelaide, Adelaide, SA, 5005, Australia.
authors.forename: Shi Zhang
authors.initials: SZ
authors.lastname: Qiao
mesh_terms: D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004705:Endocytosis / Q000187:drug effects; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D057446:Hydrodynamics; D008024:Ligands; D013058:Mass Spectrometry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D055672:Static Electricity; D013818:Thermogravimetry
chemical_list: D008024:Ligands; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: cancer therapy; dexamethasone; doxorubicin; drug delivery; mesoporous silica