title: PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapment on Polytetrafluoroethylene Surface for Application in Periodontal Diseases.
abstract: Inert polytetrafluoroethylene (PTFE) membranes for periodontal regeneration suffer from weak osteoconductive properties. In this work, a strategy for hydroxyapatite (HAp) coating on PTFE films through an adhesive layer of self-polymerized 3,4-dihydroxy-DL-phenylalanine (polyDOPA) was developed to improve surface properties. Physico-chemical and morphological analysis demonstrated the deposition of polyDOPA and HAp, with an increase in surface roughness and wettability. A discontinuous coating was present after 14 days in PBS and MC3T3-E1 cells proliferation and adhesion were improved. Results confirmed the potential application of polyDOPA/HAp-coated films for periodontal disease treatments.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Torino, Italy.|Department of Biomedical Engineering, 740 Penfield - Genome Building, Room 4300, McGillUniversity, Montreal, H3A 0G1 Quebec, Canada.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Nardo
authors.affiliation: Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Torino, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Chiono
authors.affiliation: Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Torino, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Ciardelli
authors.affiliation: Department of Biomedical Engineering, 740 Penfield - Genome Building, Room 4300, McGillUniversity, Montreal, H3A 0G1 Quebec, Canada. maryam.tabrizian@mcgill.ca.
authors.forename: Maryam
authors.initials: M
authors.lastname: Tabrizian
mesh_terms: D000818:Animals; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D008567:Membranes, Artificial; D051379:Mice; D010510:Periodontal Diseases / Q000378:metabolism / Q000628:therapy; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D011138:Polytetrafluoroethylene / Q000737:chemistry / Q000494:pharmacology
chemical_list: D020099:Coated Materials, Biocompatible; D007211:Indoles; D008567:Membranes, Artificial; D011108:Polymers; C568283:polydopamine; D011138:Polytetrafluoroethylene; D017886:Durapatite
keywords: 3,4-dihydroxy-DL-phenylalanine (DOPA); hydroxyapatite; polytetrafluoroethylene coating; scaffold; surface modification