title: Bioresorbable scaffolds in daily clinical routine: a practical review of all-comers results.
abstract: OBJECTIVE
  Bioresorbable scaffolds (BRS) are a major advancement in interventional cardiology, but experience with BRS use in daily routine is currently limited. Here, we review technical features of commercially available BRS and place them in context with current clinical scientific evidence.
  
  
  RESULTS
  Everolimus and novolimus-eluting poly-L-lactic acid (PLLA)-based BRS are commercially available in Europe. The everolimus-eluting BRS is the most widely investigated BRS and several all-comers investigations with this device are ongoing. Of the patients in these studies, 37-100% underwent catheterization due to acute coronary syndrome and up to 25% were diabetic. Up to 64.7% of all lesions treated were considered to be complex. Follow-up varied between 30 days and 1 year. The target lesion revascularization rate was up to 10% and scaffold thrombosis was 0-3%.
  
  
  CONCLUSIONS
  Accumulating data on BRS application are now available. Several studies have demonstrated that BRS implantation is technically feasible in a variety of different patient subsets and clinical presentations, and follow-up results support BRS use. Patients with acute coronary syndrome represent the most investigated subpopulation, and results suggest that BRS use for this indication is reasonable.
authors.affiliation: aUniversity of Giessen, Medizinische Klinik I, Department of Cardiology, Giessen bDeutsches Herzzentrum München, Munich cKerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Wiebe
authors.forename: Christian W
authors.initials: CW
authors.lastname: Hamm
authors.forename: Holger M
authors.initials: HM
authors.lastname: Nef
mesh_terms: D020341:Absorbable Implants; D020099:Coated Materials, Biocompatible; D003324:Coronary Artery Disease / Q000601:surgery*; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011474:Prosthesis Design; D054457:Tissue Scaffolds; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible