title: Drosophila chitinous aECM and its cellular interactions during tracheal development.
abstract: The morphology of organs, and hence their proper physiology, relies to a considerable extent on the extracellular matrix (ECM) secreted by their cells. The ECM is a structure contributed to and commonly shared by many cells in an organism that plays an active role in morphogenesis. Increasing evidence indicates that the ECM not only provides a passive contribution to organ shape but also impinges on cell behaviour and genetic programmes. The ECM is emerging as a direct modulator of many aspects of cell biology, rather than as a mere physical network that supports cells. Here, we review how the apical chitinous ECM is generated in Drosophila trachea and how cells participate in the formation of this supracellular structure. We discuss recent findings on the molecular and cellular events that lead to the formation of this apical ECM (aECM) and how it is influenced and affects tracheal cell biology.
authors.affiliation: Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, Barcelona, Spain.|Institut de Recerca Biomedica de Barcelona (IRB Barcelona), Parc Cientific de Barcelona, Barcelona, Spain.
authors.forename: Arzu
authors.initials: A
authors.lastname: Öztürk-Çolak
authors.affiliation: Animal Genetics, Interfaculty Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany.|Institute of Biology Valrose (IBV), University of Nice-Sophia Antipolis, Université de Nice - Faculté des Sciences-Parc Valrose, Nice, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Moussian
authors.affiliation: Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, Barcelona, Spain.|Institut de Recerca Biomedica de Barcelona (IRB Barcelona), Parc Cientific de Barcelona, Barcelona, Spain.
authors.forename: Sofia J
authors.initials: SJ
authors.lastname: Araújo
mesh_terms: D000825:Animal Structures / Q000196:embryology*; D000818:Animals; D002686:Chitin / Q000378:metabolism*; D004331:Drosophila melanogaster; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000196:embryology*; D005109:Extracellular Matrix / Q000378:metabolism*; D038081:Organogenesis / Q000502:physiology*
chemical_list: D002686:Chitin
keywords: Drosophila; aECM; apical; chitin; taenidia; trachea