title: A Central Hyporeflective Subretinal Lucency Correlates With a Region of Focal Leakage on Fluorescein Angiography in Eyes With Central Serous Chorioretinopathy.
abstract: OBJECTIVE
  To correlate the appearance of a hyporeflective lucency on spectral-domain optical coherence tomography (SD-OCT) with a focal leak on fluorescein angiography (FA) in eyes with central serous chorioretinopathy (CSC).
  
  
  METHODS
  Multimodal imaging of 18 patients with CSC who had hyperreflective fibrin surrounding a hyporeflective lucency on SD-OCT was analyzed to investigate any potential correlation with an active leak on FA. The lucent area was evaluated using en face imaging and followed for resolution of the active leak.
  
  
  RESULTS
  High-resolution SD-OCT images of the lucency were found to correlate with the active leak. In certain cases, the lucent area could be visualized as communicating with a defect in a pigment epithelial detachment. En face imaging of the lucency revealed a smoke-stack appearance, and resolution of the leak correlated with the disappearance of the lucency on SD-OCT.
  
  
  CONCLUSIONS
  Visualization of a lucency within surrounding fibrin may suggest an active leak. En face imaging of the lucency may provide insight into the pathophysiology of the smoke-stack leak on FA.
authors.forename: Nicolas A
authors.initials: NA
authors.lastname: Yannuzzi
authors.forename: Sarah
authors.initials: S
authors.lastname: Mrejen
authors.forename: Vittorio
authors.initials: V
authors.lastname: Capuano
authors.forename: Kavita V
authors.initials: KV
authors.lastname: Bhavsar
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: K Bailey
authors.initials: KB
authors.lastname: Freund
mesh_terms: D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D002199:Capillary Permeability; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D010778:Photochemotherapy; D012171:Retinal Vessels / Q000378:metabolism / Q000473:pathology*; D013148:Spironolactone / Q000627:therapeutic use; D058471:Subretinal Fluid / Q000378:metabolism*; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity / Q000502:physiology
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D013148:Spironolactone