title: Response evaluation in mesothelioma: Beyond RECIST.
abstract: Malignant pleural mesothelioma (MPM) typically demonstrates a non-spherical growth pattern, so it is often difficult to accurately categorize change in tumour burden using size-based tumour response criteria (e.g., WHO (World Health Organisation), RECIST (Response Evaluation Criteria in Solid Tumours) and modified RECIST). Functional imaging techniques are applied to derive quantitative measurements of tumours, which reflect particular aspects of the tumour pathophysiology. By quantifying how these measurements change with treatment, it is possible to observe treatment effects. In this review, we survey the existing roles of CT and MRI for the management of MPM, including the currently applied size measurement criteria for the assessment of treatment response. New functional imaging techniques, such as positron emission tomography (PET), diffusion-weighted MRI (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) that may potentially improve the assessment of treatment response will be highlighted and discussed.
authors.affiliation: EPSRC-CR UK Cancer Imaging Centre, Institute of Cancer Research, UK.
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
authors.affiliation: EPSRC-CR UK Cancer Imaging Centre, Institute of Cancer Research, UK; Department of Radiology, Royal Marsden Hospital, UK.
authors.forename: Nina
authors.initials: N
authors.lastname: Tunariu
authors.affiliation: EPSRC-CR UK Cancer Imaging Centre, Institute of Cancer Research, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Collins
authors.affiliation: EPSRC-CR UK Cancer Imaging Centre, Institute of Cancer Research, UK.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Blackledge
authors.affiliation: Department of Radiology, Royal Marsden Hospital, UK.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Riddell
authors.affiliation: EPSRC-CR UK Cancer Imaging Centre, Institute of Cancer Research, UK.
authors.forename: Martin O
authors.initials: MO
authors.lastname: Leach
authors.affiliation: Department of Medical Oncology, Royal Marsden Hospital, UK.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Popat
authors.affiliation: EPSRC-CR UK Cancer Imaging Centre, Institute of Cancer Research, UK; Department of Radiology, Royal Marsden Hospital, UK. Electronic address: dowmukoh@icr.ac.uk.
authors.forename: Dow-Mu
authors.initials: DM
authors.lastname: Koh
mesh_terms: D019468:Disease Management; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D008654:Mesothelioma / Q000175:diagnosis* / Q000628:therapy; D000086002:Mesothelioma, Malignant; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods; D066066:Response Evaluation Criteria in Solid Tumors; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: CT; DCE-MRI; DWI; Mesothelioma; PET; Treatment response evaluation