title: Proliferation control in neural stem and progenitor cells.
abstract: Neural circuit function can be drastically affected by variations in the number of cells that are produced during development or by a reduction in adult cell number owing to disease. For this reason, unique cell cycle and cell growth control mechanisms operate in the developing and adult brain. In Drosophila melanogaster and in mammalian neural stem and progenitor cells, these mechanisms are intricately coordinated with the developmental age and the nutritional, metabolic and hormonal state of the animal. Defects in neural stem cell proliferation that result in the generation of incorrect cell numbers or defects in neural stem cell differentiation can cause microcephaly or megalencephaly.
authors.affiliation: Institute of Molecular Biotechnology, Dr. Bohr Gasse 3, 1030, Vienna, Austria.|Chronic Diseases Research Center, NOVA Medical School, Rua Camara Pestana, 6, 1150-082 Lisbon, Portugal.
authors.forename: Catarina C F
authors.initials: CC
authors.lastname: Homem
authors.affiliation: Institute of Molecular Biotechnology, Dr. Bohr Gasse 3, 1030, Vienna, Austria.
authors.forename: Marko
authors.initials: M
authors.lastname: Repic
authors.affiliation: Institute of Molecular Biotechnology, Dr. Bohr Gasse 3, 1030, Vienna, Austria.
authors.forename: Jürgen A
authors.initials: JA
authors.lastname: Knoblich
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000502:physiology*; D004331:Drosophila melanogaster; D006801:Humans; D051379:Mice; D008831:Microcephaly / Q000473:pathology; D019579:Neocortex / Q000166:cytology* / Q000254:growth & development / Q000502:physiology*; D058953:Neural Stem Cells / Q000502:physiology*; D009457:Neuroglia / Q000502:physiology; D013234:Stem Cells / Q000502:physiology