title: Circulating thrombospondine-2 in patients with moderate-to-severe chronic heart failure due to coronary artery disease.
abstract: Chronic heart failure (CHF) remains a leading cause of morbidity and mortality. In the current study, we aimed to evaluate the predictive value of circulating thrombospondin-2 (TSP-2) for cumulative survival in patients with ischemic CHF due to coronary artery disease (CAD). The results showed that during a median follow-up of 2.18 years, 21 participants died and 106 subjects were hospitalized repeatedly. The median circulating levels of TSP-2 in patients who survived and those who died were 0.63 ng/mL (95%CI=0.55-0.64 ng/mL) and 1.03 ng/mL (95% CI=0.97-1.07 ng/mL) (P<0.001). Circulating TSP-2 independently predicted all-cause mortality (OR=1.27; 95%CI=1.08-1.59; P=0.002), CHF-related death (OR=1.16; 95%CI=1.02-1.50; P<0.001), and also CHF-related rehospitalization (OR=1.12; 95%CI=1.07-1.25; P<0.001). In conclusion, among CAD patients with symptomatic CHF, increased circulating TSP-2 is correlated with increased 3-year CHF-related death, all-cause mortality, and risk for recurrent hospitalization.
authors.affiliation: Department of Internal Medicine; Department of Clinical Pharmacology, State Medical University, Zaporozhye 69035, Ukraine. dr_berezin@mail.ru.
authors.forename: Alexander E
authors.initials: AE
authors.lastname: Berezin
authors.affiliation: Department of Internal Medicine; Department of Clinical Pharmacology, State Medical University, Zaporozhye 69035, Ukraine.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Kremzer
authors.affiliation: Department of Internal Medicine; Department of Clinical Pharmacology, State Medical University, Zaporozhye 69035, Ukraine.
authors.forename: Tatayna A
authors.initials: TA
authors.lastname: Samura
keywords: chronic heart failure; hospitalization; prognosis; survival; thrombospondine-2