title: Transdifferentiation of differentiated stem cells contributes to remyelination.
abstract: Evidence suggests that transdifferentiation of mesenchymal stem cells (MSCs) into various neuronal cells contributes to functional recovery after experimental spinal cord injury. Qiu et al. have recently published an exciting article in Stem Cell Research & Therapy demonstrating the transdifferentiation of already differentiated MSCs that contributes to remyelination of injured/regenerating axons, and thereby to functional recovery of spinal cord injured animals. The authors highlight the importance of interaction between neurotrophin-3 and tropomyosin receptor kinase C for the observed effects. This study provided important evidence that manipulation of rat bone marrow-derived MSCs before transplantation could enhance the therapeutic benefit of cell-based treatment.
authors.affiliation: Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, 1 Illini Drive, Peoria, IL, 61605, USA. bharathc@uic.edu.
authors.forename: Bharath
authors.initials: B
authors.lastname: Chelluboina
authors.affiliation: Department of Neurosurgery, University of Illinois College of Medicine at Peoria, 530 N.E. Glen Oak Ave., Peoria, IL, 61637, USA. ddinh@uic.edu.|Illinois Neurological Institute, OSF Saint Francis Medical Center, 530 N.E. Glen Oak Ave., Peoria, IL, 61637, USA. ddinh@uic.edu.
authors.forename: Dzung H
authors.initials: DH
authors.lastname: Dinh
authors.affiliation: Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, 1 Illini Drive, Peoria, IL, 61605, USA. krishnav@uic.edu.
authors.forename: Krishna Kumar
authors.initials: KK
authors.lastname: Veeravalli
mesh_terms: D000818:Animals; D054338:Cell Transdifferentiation; D002478:Cells, Cultured; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D009186:Myelin Sheath / Q000502:physiology*; D009414:Nerve Growth Factors / Q000502:physiology; D051381:Rats; D020812:Receptor, trkC / Q000378:metabolism; D012038:Regeneration; D044968:Regenerative Medicine
chemical_list: D009414:Nerve Growth Factors; D020812:Receptor, trkC