title: Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns.
abstract: To compare patterns of gene expression following preconditioning cyclic light rearing versus preconditioning aerobic exercise. BALB/C mice were preconditioned either by rearing in 800 lx 12:12 h cyclic light for 8 days or by running on treadmills for 9 days, exposed to toxic levels of light to cause light-induced retinal degeneration (LIRD), then sacrificed and retinal tissue harvested. Subsets of mice were maintained for an additional 2 weeks and for assessment of retinal function by electroretinogram (ERG). Both preconditioning protocols partially but significantly preserved retinal function and morphology and induced similar leukemia inhibitory factor (LIF) gene expression pattern. The data demonstrate that exercise preconditioning and cyclic light preconditioning protect photoreceptors against LIRD and evoke a similar pattern of retinal LIF gene expression. It may be that similar stress response pathways mediate the protection provided by the two preconditioning modalities.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. mchrene@emory.edu.
authors.forename: Micah A
authors.initials: MA
authors.lastname: Chrenek
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. jana.t.sellers@emory.edu.
authors.forename: Jana T
authors.initials: JT
authors.lastname: Sellers
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. eric.lawson90@gmail.com.|Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. eric.lawson90@gmail.com.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Lawson
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. priscila.cunha@emory.edu.
authors.forename: Priscila P
authors.initials: PP
authors.lastname: Cunha
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. Jessica.johnson@emory.edu.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Johnson
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. preston.girardot@emory.edu.
authors.forename: Preston E
authors.initials: PE
authors.lastname: Girardot
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. cristina.kendall@gmail.com.
authors.forename: Cristina
authors.initials: C
authors.lastname: Kendall
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. zlalunar@hotmail.com.|Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. zlalunar@hotmail.com.
authors.forename: Moon K
authors.initials: MK
authors.lastname: Han
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. ahanif@emory.edu.|Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. ahanif@emory.edu.
authors.forename: Adam
authors.initials: A
authors.lastname: Hanif
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. vciavat@emory.edu.|Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. vciavat@emory.edu.
authors.forename: Vincent T
authors.initials: VT
authors.lastname: Ciavatta
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. mgognia@emory.edu.|Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. mgognia@emory.edu.
authors.forename: Marissa A
authors.initials: MA
authors.lastname: Gogniat
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. litjn@emory.edu.
authors.forename: John M
authors.initials: JM
authors.lastname: Nickerson
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. mpardue@emory.edu.|Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. mpardue@emory.edu.
authors.forename: Machelle T
authors.initials: MT
authors.lastname: Pardue
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. jboatri@emory.edu.|Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. jboatri@emory.edu.
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Boatright
mesh_terms: D000818:Animals; D004596:Electroretinography; D053605:Leukemia Inhibitory Factor / Q000235:genetics; D008027:Light / Q000009:adverse effects; D008297:Male; D008807:Mice, Inbred BALB C; D017440:Photoperiod; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012160:Retina / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D012162:Retinal Degeneration / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D059467:Transcriptome / Q000235:genetics* / Q000528:radiation effects
chemical_list: D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse
keywords: Aerobic exercise; Cyclic light rearing; Light-induced retinal degeneration; Preconditioning; Retinal degeneration