title: Association of serum N-terminal pro-brain natriuretic peptide levels with the severity of preeclampsia.
abstract: OBJECTIVE
  To investigate whether serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels could be used as a marker to determine the severity of preeclampsia.
  
  
  METHODS
  This prospective cohort study included pregnant women with preeclampsia and severe preeclampsia and normotensive pregnant controls admitted between January 2013 and July 2014. Preeclampsia was graded according to the recently revised criteria of the American College of Obstetricians and Gynecologists (ACOG). Serum NT-proBNP levels were compared among the groups.
  
  
  RESULTS
  Of the 49 women with preeclampsia, 25 had severe preeclampsia. The controls were 27 normotensive pregnant women admitted during the same period. Serum NT-proBNP levels were significantly higher in the preeclampsia groups than in the control group (p < 0.001). In addition, NT-proBNP levels were significantly higher in the severe preeclampsia group compared with both the preeclampsia group (p < 0.001) and the control group (p < 0.001).
  
  
  CONCLUSIONS
  The ACOG has recently revised the grading of hypertensive diseases of pregnancy and the criteria for severe preeclampsia. In line with these revised guidelines, serum NT-proBNP levels appear to be a useful marker to evaluate the severity of preeclampsia.
authors.affiliation: a Department of Obstetrics and Gynecology , School of Medicine, Kahramanmaras Sutcu Imam University , Kahramanmaraş , Turkey and.
authors.forename: Murat
authors.initials: M
authors.lastname: Bakacak
authors.affiliation: a Department of Obstetrics and Gynecology , School of Medicine, Kahramanmaras Sutcu Imam University , Kahramanmaraş , Turkey and.
authors.forename: Salih
authors.initials: S
authors.lastname: Serin
authors.affiliation: a Department of Obstetrics and Gynecology , School of Medicine, Kahramanmaras Sutcu Imam University , Kahramanmaraş , Turkey and.
authors.forename: Onder
authors.initials: O
authors.lastname: Ercan
authors.affiliation: a Department of Obstetrics and Gynecology , School of Medicine, Kahramanmaras Sutcu Imam University , Kahramanmaraş , Turkey and.
authors.forename: Bülent
authors.initials: B
authors.lastname: Köstü
authors.affiliation: b Department of Obstetrics and Gynecology , Private Caka Vatan Hospital , Kahramanmaraş , Turkey.
authors.forename: Zeyneb
authors.initials: Z
authors.lastname: Bakacak
authors.affiliation: a Department of Obstetrics and Gynecology , School of Medicine, Kahramanmaras Sutcu Imam University , Kahramanmaraş , Turkey and.
authors.forename: Hakan
authors.initials: H
authors.lastname: Kiran
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: N-terminal pro-brain natriuretic peptide; preeclampsia; severe preeclampsia