title: Gene-pseudogene evolution: a probabilistic approach.
abstract: Over the last decade, methods have been developed for the reconstruction of gene trees that take into account the species tree. Many of these methods have been based on the probabilistic duplication-loss model, which describes how a gene-tree evolves over a species-tree with respect to duplication and losses, as well as extension of this model, e.g., the DLRS (Duplication, Loss, Rate and Sequence evolution) model that also includes sequence evolution under relaxed molecular clock. A disjoint, almost as recent, and very important line of research has been focused on non protein-coding, but yet, functional DNA. For instance, DNA sequences being pseudogenes in the sense that they are not translated, may still be transcribed and the thereby produced RNA may be functional.
authors.forename: Owais
authors.initials: O
authors.lastname: Mahmudi
authors.forename: Bengt
authors.initials: B
authors.lastname: Sennblad
authors.forename: Lars
authors.initials: L
authors.lastname: Arvestad
authors.forename: Katja
authors.initials: K
authors.lastname: Nowick
authors.forename: Jens
authors.initials: J
authors.lastname: Lagergren
mesh_terms: D004247:DNA / Q000235:genetics*; D019143:Evolution, Molecular; D020440:Gene Duplication; D010802:Phylogeny; D011544:Pseudogenes / Q000235:genetics*
chemical_list: D004247:DNA