title: Endoscopic submucosal dissection for early gastric cancer in elderly patients: a meta-analysis.
abstract: BACKGROUND
  The effectiveness of endoscopic submucosal dissection (ESD) has been increasingly reported. However, studies addressing the safety and application value of ESD in elderly patients with early gastric cancer (EGC) were still lacking. This meta-analysis was intended to evaluate the feasibility and safety of ESD in elderly patients with EGC.
  
  
  METHODS
  A systematic search was conducted in PubMed, EBSCO, Cochrane Library, EMBASE, and Web of Science. Studies were screened out if data of elderly and non-elderly gastric cancer patients were reported separately. The qualities of included studies were assessed using Newcastle-Ottawa Quality Assessment Scale. The pooled odd ratios (ORs) with 95 % confidence intervals (CIs) were calculated. Statistical analysis was conducted using the Review Manager 5.2 (Cochrane Collaboration, Oxford, UK).
  
  
  RESULTS
  Nine studies (eight in Japan, one in China), including a total of 30,100 lesions, met the inclusion criteria. The "en bloc" and histological complete resection rates of the elderly and non-elderly groups were similar [OR, 0.98, 95 % CI, 0.56 to 1.71; P = 0.93 and OR, 0.79, 95 % CI, 0.58 to 1.07; P = 0.13, respectively]. As for procedure-related complications, similar perforation rates [OR, 1.19, 95 % CI, 0.94 to 1.51; P = 0.15], and bleeding rates [OR, 1.13, 95 % CI, 0.83 to 1.56); P = 0.43] between the elderly and non-elderly groups were observed. Whereas, the elderly patients had a higher procedure-related pneumonia rate compared with non-elderly ones [OR, 2.18, 95 % CI, 1.55 to 3.08; P < 0.01].
  
  
  CONCLUSIONS
  The ESD procedure appears to be a safe technique in elderly patients with EGC while appropriate approach should be taken to avoid procedure-related pneumonia.
authors.affiliation: Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China.|Institute of Gastroenterology, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China.
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Lin
authors.affiliation: Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, People's Republic of China.|Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou, Peoples' Republic of China.
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China.|Institute of Gastroenterology, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China.
authors.forename: Meng
authors.initials: M
authors.lastname: Xue
authors.affiliation: Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China. chensj77@hotmail.com.|Institute of Gastroenterology, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China. chensj77@hotmail.com.
authors.forename: Shu-jie
authors.initials: SJ
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China. jianmin_si@zju.edu.cn.|Institute of Gastroenterology, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China. jianmin_si@zju.edu.cn.
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Si
mesh_terms: D000367:Age Factors; D000368:Aged; D004210:Dissection; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery; D005773:Gastroscopy; D006801:Humans; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome