title: Optical coherence tomography imaging of the basal ganglia: feasibility and brief review.
abstract: Optical coherence tomography (OCT) is a promising medical imaging technique that uses light to capture real-time cross-sectional images from biological tissues in micrometer resolution. Commercially available optical coherence tomography systems are employed in diverse applications, including art conservation and diagnostic medicine, notably in cardiology and ophthalmology. Application of this technology in the brain may enable distinction between white matter and gray matter, and obtainment of detailed images from within the encephalon. We present, herein, the in vivo implementation of OCT imaging in the rat brain striatum. For this, two male 60-day-old rats (Rattus norvegicus, Albinus variation, Wistar) were stereotactically implanted with guide cannulas into the striatum to guide a 2.7-French diameter high-definition OCT imaging catheter (Dragonfly™, St. Jude Medical, USA). Obtained images were compared with corresponding histologically stained sections to collect imaging samples. A brief analysis of OCT technology and its current applications is also reported, as well as intra-cerebral OCT feasibility on brain mapping during neurosurgical procedures.
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: W O Contreras
authors.initials: WO
authors.lastname: Lopez
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: J S
authors.initials: JS
authors.lastname: Ângelos
authors.affiliation: Laboratório de Neuromodulação e Dor Experimental, Hospital Sírio-Libanês, São Paulo, SP, Brasil.
authors.forename: R C R
authors.initials: RC
authors.lastname: Martinez
authors.affiliation: Instituto do Coração, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: C K
authors.initials: CK
authors.lastname: Takimura
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: M J
authors.initials: MJ
authors.lastname: Teixeira
authors.affiliation: Instituto do Coração, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: P A
authors.initials: PA
authors.lastname: Lemos Neto
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: E T
authors.initials: ET
authors.lastname: Fonoff
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000033:anatomy & histology*; D003199:Computer Systems / Q000592:standards; D003342:Corpus Striatum / Q000033:anatomy & histology; D003936:Diagnosis, Computer-Assisted; D005240:Feasibility Studies; D008297:Male; D017208:Rats, Wistar; D013238:Stereotaxic Techniques; D041623:Tomography, Optical Coherence / Q000592:standards