title: Viral hepatitis: A new HCV cell culture model for the next clinical challenges.
abstract: Despite advances in hepatitis C treatment, substantial clinical hurdles remain to achieve universal cure and global control of infection. Saeed et al. identified SEC14L2 as a host factor permitting replication of clinical HCV isolates in cell culture, providing a novel system to model infection of patient-derived viruses.
authors.affiliation: Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg, 67000 Strasbourg, France.
authors.forename: Che C
authors.initials: CC
authors.lastname: Colpitts
authors.affiliation: Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg, 67000 Strasbourg, France.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Baumert
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000821:virology*; D002352:Carrier Proteins / Q000378:metabolism*; D018929:Cell Culture Techniques; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000254:growth & development*; D058605:Host-Derived Cellular Factors / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D002352:Carrier Proteins; D058605:Host-Derived Cellular Factors; D008074:Lipoproteins; D015534:Trans-Activators