title: Applicability of modified Glasgow Prognostic Score in the assessment of elderly patients with cancer: A pilot study.
abstract: OBJECTIVE
  To evaluate the relationship between inflammatory parameters through the modified Glasgow Prognostic Score (mGPS) and other clinical characteristics of elderly patients with cancer, including frailty evaluated by the Edmonton Frailty Scale (EFS).
  
  
  METHODS
  We included patients from the oncology service at Faculdade de Medicina do ABC with a confirmed diagnosis of solid tumor aged 65 years or more at diagnosis. Patients were assessed by applying the translated and validated to Portuguese version of the EFS and also had blood sample collection for the evaluation of C-reactive protein (CRP) and albumin for calculation of the mGPS.
  
  
  RESULTS
  We included 52 patients of both sexes, with median age of 72.5 years, of these 67.3% had localized disease and 32.7% metastatic disease. The mGPS presented 17.3% of high-risk patients. The frailty evaluated by EFS occurred in 57.6% of patients. Patients with both abnormal parameters (CRP and albumin) in the mGPS had significantly higher scores on EFS when compared to those with no change (6 vs. 9.56 points, p=0.021). The mGPS correlated also with clinical staging (p=0.019) and performance status (p=0.039).
  
  
  CONCLUSIONS
  Inflammatory parameters correlate significantly with frailty, more advanced clinical stage and poor functional status.
authors.affiliation: Department of Clinical Oncology, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, CEP. 09060-650 Santo André, São Paulo, Brazil.
authors.forename: Viviane
authors.initials: V
authors.lastname: Lealdini
authors.affiliation: Department of Oncology and Hematology Discipline, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, CEP. 09060-650 Santo André, São Paulo, Brazil. Electronic address: damilatrufelli@yahoo.com.br.
authors.forename: Damila Cristina
authors.initials: DC
authors.lastname: Trufelli
authors.affiliation: Department of Clinical Oncology, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, CEP. 09060-650 Santo André, São Paulo, Brazil.
authors.forename: Fernanda Borges Ferreira
authors.initials: FB
authors.lastname: da Silva
authors.affiliation: Department of Clinical Oncology, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, CEP. 09060-650 Santo André, São Paulo, Brazil.
authors.forename: Savia Raquel Costa
authors.initials: SR
authors.lastname: Normando
authors.affiliation: Department of Clinical Oncology, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, CEP. 09060-650 Santo André, São Paulo, Brazil.
authors.forename: Elisa Watanabe
authors.initials: EW
authors.lastname: Camargo
authors.affiliation: Department of Public Health, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, CEP. 09060-650 Santo André, São Paulo, Brazil.
authors.forename: Leandro Luongo de
authors.initials: LL
authors.lastname: Matos
authors.affiliation: Department of the Clinical Laboratory, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, CEP. 09060-650 Santo André, São Paulo, Brazil.
authors.forename: Fernando Luiz Affonso
authors.initials: FL
authors.lastname: Fonseca
authors.affiliation: Department of Oncology and Hematology Discipline, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, CEP. 09060-650 Santo André, São Paulo, Brazil.
authors.forename: Patricia Xavier
authors.initials: PX
authors.lastname: Santi
authors.affiliation: Department of Clinical Oncology, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, CEP. 09060-650 Santo André, São Paulo, Brazil.
authors.forename: Auro
authors.initials: A
authors.lastname: Del Giglio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D010865:Pilot Projects; D011379:Prognosis; D012709:Serum Albumin / Q000032:analysis; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D012709:Serum Albumin; D002097:C-Reactive Protein
keywords: Elderly; Neoplasia; Prognosis