title: LINE-1 activity as molecular basis for genomic instability associated with light exposure at night.
abstract: The original hypothesis that exposure to light at night increases risk of breast cancer via suppression of nocturnal melatonin production was proposed over 2 decades ago. In 2007, shift work that involves circadian disruption has been recognized by the World Health Organization as a probable human carcinogen. Our discovery of melatonin-dependent regulation of LINE-1 retrotransposon expression and mobilization is the latest addition to the list of cellular genes and processes that are affected by light exposure at night. This finding establishes an unexpected health relevant connection between this endogenous DNA damaging agent and environmental light exposure. It also offers an appealing hypothesis pertaining to the origin of genomic instability in the genomes of individuals with light at night- or age-associated disruption of melatonin signaling.
authors.affiliation: Department of Structural and Cellular Biology; Tulane Cancer Center; Tulane Cancer for Aging; Tulane Center for Circadian Biology; Tulane University ; New Orleans, LA USA.
authors.forename: Victoria P
authors.initials: VP
authors.lastname: Belancio
keywords: DNA damage; LINE-1; aging; cancer; genomic instability; light exposure at night; melatonin; melatonin receptor; retroelements; shift-work