title: Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii.
abstract: The ascomycete Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. Three new steroids (1-3), two of which are present as glycosides, with an untypical pattern of carbon-carbon double bounds, were obtained from fungal extracts, as well as the known xanthocillin X dimethyl ether (4). Compounds 2 and 4 were evaluated in an Alzheimer's disease cellular assay and found capable of preventing the enhanced production of amyloid β-42 in Aftin-5 treated cells. Aβ-42 lowering agents are considered as candidates for the treatment of neurodegenerative Alzheimer's disease.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Harms
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.
authors.forename: Damun
authors.initials: D
authors.lastname: Nesaei-Mosaferan
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Hufendieck
authors.affiliation: ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Meijer
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany. Electronic address: g.koenig@uni-bonn.de.
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000096:biosynthesis*; D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D002070:Butadienes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D010446:Peptide Fragments / Q000096:biosynthesis*; D011161:Porifera / Q000382:microbiology*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D016229:Amyloid beta-Peptides; D002070:Butadienes; D010446:Peptide Fragments; D013261:Sterols; C075222:amyloid beta-protein (1-42); C000611288:xanthocillin X dimethyl ether
keywords: Alzheimer’s disease; Dichotomomyces cejpii; Ergosterol derivatives