title: Strategies For Immobilization Of Bioactive Organic Molecules On Titanium Implant Surfaces - A Review.
abstract: Numerous approaches have been used to improve the tissue-implant interface of titanium (Ti) and titanium alloy (Ti6Al4V). They all aim at increasing cell migration and attachment to the metal, preventing unspecific protein adsorption and improving post-implantation healing process. Promising methods for titanium and titanium alloy surface modification are based on the immobilization of biologically active organic molecules. New and interesting biochemical approaches to such surface modification include layer-by-layer deposition of polyelectrolyte films, phage display-selected surface binding peptides and self-assembled DNA monolayer systems. The present review summarizes the scientific information about these methods, which are at in vitro or in vivo development stages, and hopes to promote their future application in dental implantology and in oral and maxillofacial surgery.
authors.affiliation: EA4203 Laboratoire de Bioingénierie et Nanoscience, Université de Montpellier, Montpellier, France
authors.forename: Ivan V
authors.initials: IV
authors.lastname: Panayotov
authors.affiliation: Department of Maxillofacial Surgery, Faculty of Dental Medicine, Medical University, Plovdiv, Bulgaria
authors.forename: Boyan S
authors.initials: BS
authors.lastname: Vladimirov
authors.affiliation: EA4203 Laboratoire de Bioingénierie et Nanoscience, Université de Montpellier, Montpellier, France
authors.forename: Pierre-Yves C
authors.initials: PY
authors.lastname: Dutilleul
authors.affiliation: EA4203 Laboratoire de Bioingénierie et Nanoscience, Université de Montpellier, Montpellier, France
authors.forename: Bernard
authors.initials: B
authors.lastname: Levallois
authors.affiliation: EA4203 Laboratoire de Bioingénierie et Nanoscience, Université de Montpellier, Montpellier, France
authors.forename: Frédéric
authors.initials: F
authors.lastname: Cuisinier
mesh_terms: D000327:Adsorption; D000497:Alloys; D000595:Amino Acid Sequence; D001798:Blood Proteins / Q000737:chemistry; D015921:Dental Implants; D055767:Immobilized Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D013499:Surface Properties; D014025:Titanium
chemical_list: D000497:Alloys; D001798:Blood Proteins; D015921:Dental Implants; D055767:Immobilized Proteins; C031462:titanium alloy (TiAl6V4); D014025:Titanium