title: Circadian Kisspeptin expression in human term placenta.
abstract: Kisspeptin is an essential gatekeeper of reproductive function. During pregnancy high circulating levels of kisspeptin have been described, however the clear role of this neuropeptide in pregnancy remains unknown. We tested the existence of rhythmic kisspeptin expression in human full-term placenta from healthy pregnant women at six different time points during the day. The data obtained by Western blotting were fitted to a mathematical model (Fourier series), demonstrating, for the first time, the existence of a circadian rhythm in placental kisspeptin expression.
authors.affiliation: Area of Physiology, Department of Functional Biology, University of Oviedo, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: de Pedro
authors.affiliation: Area of Physiology, Department of Functional Biology, University of Oviedo, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Morán
authors.affiliation: Area of Computer Science and Artificial Intelligence, Department of Computer Science, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Díaz
authors.affiliation: Area of Physiology, Department of Functional Biology, University of Oviedo, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Murias
authors.affiliation: Department of Gynecology and Obstetrics, Central University Hospital of Asturias (HUCA), Spain.
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Plaza
authors.affiliation: Area of Physiology, Department of Functional Biology, University of Oviedo, Spain.
authors.forename: C
authors.initials: C
authors.lastname: González
authors.affiliation: Area of Physiology, Department of Functional Biology, University of Oviedo, Spain. Electronic address: elenadr@uniovi.es.
authors.forename: E
authors.initials: E
authors.lastname: Díaz
mesh_terms: D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D059648:Kisspeptins / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D059648:Kisspeptins
keywords: Circadian rhythm; Fourier series; Full-term placenta; Kisspeptin; Western blot