title: Long-Range Chromatin Interactions.
abstract: To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.
authors.affiliation: University of Massachusetts Medical School, Worcester, Massachusetts 01605.
authors.forename: Job
authors.initials: J
authors.lastname: Dekker
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism / Q000502:physiology*; D002874:Chromosome Mapping; D002875:Chromosomes / Q000648:ultrastructure; D005786:Gene Expression Regulation; D015723:Gene Library; D023281:Genomics; D006801:Humans; D051379:Mice; D005810:Multigene Family; D012343:RNA, Transfer / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D002843:Chromatin; D014157:Transcription Factors; D012343:RNA, Transfer