title: Circulating Levels of Uric Acid and Risk for Metabolic Syndrome.
abstract: Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid, both mechanisms link elevated serum uric acid with metabolic syndrome. The aim of this study is to evaluate the probability for the development of metabolic syndrome in low-income young adults with hyperuricaemia.
  
  
  METHODS
  We evaluated 103 patients less than 40 years of age, from a low-income population, and without history of cardiovascular disease, in all of them the presence of metabolic syndrome was assessed in accordance with the International Diabetes Federation criteria. In all patients, fasting serum uric acid levels were measured; hyperuricaemia was defined as serum uric acid values 6.5 mg/dl in men and 5.1 mg/dl in women. Statistical analysis was performed with odds ratio.
  
  
  RESULTS
  83 of our patients (80.5%) suffered metabolic syndrome, the odds ratio for the presence of metabolic syndrome in patients with hyperuricaemia was 5.1 (p=0.002, I.C 1.8- 14.5). When patients were evaluated by gender a significantly association between hyperuricaemia and metabolic syndrome was found in women (odds ratio 3.6, p=0.048, C.I. 1.0-12.9), and men (odds ratio 10.2, p= 0.015, IC 1.5-13.2). When uric acid was correlated with the components of metabolic syndrome, we only found a positive correlation with waist circumference (r=0.483).
  
  
  CONCLUSIONS
  Our results showed a significant association between hyperuricemia and metabolic syndrome in low-income young adults in Mexico. DR is associated with estimated risk of CVD in type 2 diabetic patients.
authors.affiliation: Hospital General de Ticoman SS DF. Mexican Group for Basic and Clinical Research in Internal Medicine, Motozintla, Mexico.
authors.forename: Alberto F
authors.initials: AF
authors.lastname: Rubio-Guerra
authors.forename: Herlinda
authors.initials: H
authors.lastname: Morales-López
authors.forename: Ana K
authors.initials: AK
authors.lastname: Garro-Almendaro
authors.forename: German
authors.initials: G
authors.lastname: Vargas-Ayala
authors.forename: Montserrat B
authors.initials: MB
authors.lastname: Durán-Salgado
authors.forename: Saul
authors.initials: S
authors.lastname: Huerta-Ramírez
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Lozano-Nuevo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis*; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008800:Mexico; D011203:Poverty; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference
chemical_list: D014527:Uric Acid
keywords: Metabolic syndrome; hyperuricaemia; insulin resistance; low income young adults; uric acid; waist circumference