title: Electron-based fragmentation methods in mass spectrometry: An overview.
abstract: Tandem mass spectrometry (MS/MS) provides detailed information for structural characterization of biomolecules. The combination of electron capture dissociation (ECD) techniques with Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) often provides unique ion-electron reactions and fragmentation channels in MS/MS. ECD is often a complimentary, sometimes even a superior tool to conventional MS/MS techniques. This article is aimed at providing a short overview of ECD-based fragmentation techniques (ExD) and optimization of ECD experiments for FTICR mass analyzers. Most importantly, it is meant to pique the interest of potential users for this exciting research field. © 2015 Wiley Periodicals, Inc. Mass Spec Rev 36:4-15, 2017.
authors.affiliation: Institute of Bioanalytical Chemistry, Saarland University, Campus B2.2, Saarbrücken, 66123, Germany.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Institute of Bioanalytical Chemistry, Saarland University, Campus B2.2, Saarbrücken, 66123, Germany.
authors.forename: Dietrich A
authors.initials: DA
authors.lastname: Volmer
keywords: ExD; FTICR-MS; fragmentation; ion-electron reactions