title: Villitis of unknown aetiology: Clinical implications in preterm population.
abstract: Villitis of unknown aetiology (VUE) is a chronic inflammatory process of chorionic villi which is reported to occur in up to 15% of term placentas. The present study aimed to investigate the association between VUE and perinatal complications in a population who delivered before term. Patients with VUE had a significantly higher rate of intrauterine growth restriction than the control group (47.1% vs. 20.6%, p < 0.01). In addition patients with VUE had a higher rate of deliveries due to absent diastolic flow on umbilical artery doppler than the control group (17.6% vs. 4.4%, p: 0.03). The rate of spontaneous preterm birth or pre-eclampsia was similar in patients with VUE and control groups. The present study provides some evidence that VUE is associated with abnormal perinatal outcomes in pregnant women who give birth before term.
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Research and Training Hospital , Ankara , Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Iskender
authors.affiliation: b Department of Pathology , Zekai Tahir Burak Research and Training Hospital , Ankara , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Zergeroglu
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Research and Training Hospital , Ankara , Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Kaymak
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Research and Training Hospital , Ankara , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Çelen
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Research and Training Hospital , Ankara , Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Danisman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002824:Chorionic Villi / Q000473:pathology; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology*; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D010922:Placenta Diseases / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology*; D011446:Prospective Studies; D012039:Regional Blood Flow; D018608:Ultrasonography, Doppler; D014469:Umbilical Arteries / Q000000981:diagnostic imaging; D055815:Young Adult
keywords: Perinatal complications; preterm delivery; villitis of unknown aetiology