title: Treatment of peritoneal metastases from colorectal cancer.
abstract: Peritoneal seedings of a colorectal tumor represent the second most frequent site of metastasis (after the liver). In the era of 5-fluorouracil (5-FU)-only chemotherapy, the prognosis was poor for colorectal cancer with peritoneal metastases. Within the last few years, new chemotherapeutic and targeted agents have improved the prognosis; however, the response to these treatments seems to be lower than that for liver metastases. The combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have further improved both disease-free survival and overall survival. Keeping this in mind, every patient presenting with peritoneal metastases from colorectal cancer should be evaluated and receive adequate treatment, if possible in the above-mentioned combination. This paper reviews recent advancements in the therapy of peritoneal carcinomatosis.
authors.affiliation: Department of Surgery, St. John of God Hospital Regensburg, Regensburg, Germany loreen.maerz@bazmherzige-regensburg.de.
authors.forename: Loreen
authors.initials: L
authors.lastname: März
authors.affiliation: Department of Surgery, St. John of God Hospital Regensburg, Regensburg, Germany.
authors.forename: Pompiliu
authors.initials: P
authors.lastname: Piso
keywords: colorectal cancer; cytoreductive surgery; intraperitoneal chemotherapy; peritoneal metastases