title: Implementing systems medicine within healthcare.
abstract: The cause of a complex disease cannot be pinpointed to a single origin; rather, a highly complex network of many factors that interact on different levels over time and space is disturbed. This complexity requires novel approaches to diagnosis, treatment, and prevention. To foster the necessary shift to a pro-active systems medicine, proof-of-concept studies are needed. Here, we highlight several systems approaches that have been shown to work within the field of respiratory medicine, and we propose the next steps for broader implementation.
authors.affiliation: Forschungszentrum Jülich GmbH, Jülich, Germany. m.kirschner@fz-juelich.de.
authors.forename: Marc
authors.initials: M
authors.lastname: Kirschner
authors.affiliation: Biomax Informatics AG, Planegg, Germany.
authors.forename: Angela
authors.initials: A
authors.lastname: Bauch
authors.affiliation: Hospital Clinic, Barcelona, Spain.
authors.forename: Alvar
authors.initials: A
authors.lastname: Agusti
authors.affiliation: BTA Bayerische Telemed Allianz, Ingolstadt, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Hilke
authors.affiliation: Reha-Zentrum Bad Griesbach, Bad Griesbach-Therme, Germany.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Merk
authors.affiliation: Clinique Universitaire de Pneumologie, CHU de Grenoble, La Tronche, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Pison
authors.affiliation: Linkcare Health Services, Barcelona, Spain.
authors.forename: Jim
authors.initials: J
authors.lastname: Roldan
authors.affiliation: CSU-Bürgerbüro, Dachau, Germany.
authors.forename: Bernard
authors.initials: B
authors.lastname: Seidenath
authors.affiliation: Deutsche Patientenliga Atemwegserkrankungen e.V, Oppenheim, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Wilken
authors.affiliation: CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.
authors.forename: Emiel F
authors.initials: EF
authors.lastname: Wouters
authors.affiliation: Helmholtz Zentrum München GmbH, Neuherberg, Germany.
authors.forename: Hans-Werner
authors.initials: HW
authors.lastname: Mewes
authors.affiliation: Biomax Informatics AG, Planegg, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Heumann
authors.affiliation: Biomax Informatics AG, Planegg, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Maier
mesh_terms: D003695:Delivery of Health Care; D019468:Disease Management; D006801:Humans; D013597:Systems Analysis