title: Genetic polymorphisms in TNFSF13 and FDX1 are associated with IgA nephropathy in the Han Chinese population.
abstract: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, and its pathogenesis is influenced by both genetic and environmental factors. In this study, we evaluated 23 tag single-nucleotide polymorphisms (tSNPs) in 21 IgAN-associated genes, in 200 subjects with IgAN and 310 healthy gender- and age-matched unrelated control subjects with no history of renal disease or hypertension. Using the co-dominant model, we found that two genotypes of rs3803800 in TNFSF13 were associated with an increased risk of IgAN: "GA" (OR = 1.03, 95% CI = 0.71-1.51, p = 0.018) and "AA" (OR = 2.45, 95% CI = 1.29-4.65, p = 0.018). The "AA" genotype was also associated with an increased risk of IgAN in the recessive model (OR = 2.41, 95% CI = 1.30-4.46, p = 0.018), as was the genotype "AA" rs10488764 in FDX1 (OR = 1.88, 95% CI = 1.01-3.53, p = 0.048). Interestingly, we found that the allele "A" of rs3803800 in TNFSF13 is associated with a decreased risk of IgAN in females (OR = 0.43, 95% CI = 0.20-0.95, p = 0.009), but with an increased risk in males (OR = 1.78, 95% CI = 0.86-3.66, p = 0.009). Our findings, combined with previously reported results, suggest that TNFSF13 and FDX1 have potential roles in IgAN in the Han Chinese population. This information may be useful in the development of early prognostics for IgAN.
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China; Forensic Medicine College, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Niu
authors.affiliation: Forensic Medicine College, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Liyi
authors.initials: L
authors.lastname: Xie
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Jiping
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Wanhong
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Nephrology, Shanxi Province Hospital, Xi'an 710069, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Jin
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Yaning
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Yin
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Yingzhou
authors.initials: Y
authors.lastname: Geng
authors.affiliation: Department of Nephrology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhang
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an 710069, China.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Chen
authors.affiliation: Forensic Medicine College, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Shengbin
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005288:Ferredoxins / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000235:genetics*; D055815:Young Adult
chemical_list: D005288:Ferredoxins; C114631:TNFSF13 protein, human; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13
keywords: Case–control study; IgA nephropathy (IgAN); Tag single nucleotide polymorphism (tSNP)