title: Antihyperlipidemic Effects of Sour Cherries Characterized by Different In Vitro Antioxidant Power and Polyphenolic Composition.
abstract: The aims of the present study were to clarify in vivo effects of three sour cherry cultivars characterized by different polyphenolic composition in hyperlipidemic animals in a short term experiment. The three different sour cherry cultivars were chosen based on their total in vitro antioxidant capacity, total polyphenolic, monomeric anthocyanin and flavonoid content. Male Wistar rats were divided randomly into eight groups: rats kept on normal diet (control) and normal diet supplied with sour cherry powder of one of the three cultivars; others were kept on fat-rich diet and fat-rich diet supplied with sour cherry powder prepared from one of the three cultivars. The treatment lasted 10 days. Lyophilized sour cherry administered in the diet decreased both total cholesterol and LDL cholesterol levels, and increased the HDL cholesterol concentration in sera of hyperlipidemic animals. Significant differences were found in the efficacy of different sour cherry cultivars in case of hyperlipidemia. Sour cherries characterized by higher polyphenol content seem to have a more pronounced effect on serum cholesterol levels. Our results suggest that besides anthocyanins, colourless polyphenols also have lipid lowering effect.
authors.affiliation: Department of Applied Chemistry, Faculty of Food Science, Corvinus University of Budapest, Villányi street 29-43, Budapest, Hungary.|Institute for Extension and Development, University of Debrecen, Böszörményi street 138, Debrecen, Hungary.
authors.forename: Nóra
authors.initials: N
authors.lastname: Papp
authors.affiliation: Department of Pharmacognosy, Semmelweis University, Üllői street 26, Budapest, Hungary.
authors.forename: Anna
authors.initials: A
authors.lastname: Blázovics
authors.affiliation: Research Institute for Animal Breeding and Nutrition, Gesztenyés street 1, Herceghalom, Hungary.
authors.forename: Hedvig
authors.initials: H
authors.lastname: Fébel
authors.affiliation: Department of Inorganic and Organic Chemistry, Faculty of Experimental Sciences, University of Jaén, Campus Las Lagunillas, Jaén, Spain.
authors.forename: Sofía
authors.initials: S
authors.lastname: Salido
authors.affiliation: Department of Inorganic and Organic Chemistry, Faculty of Experimental Sciences, University of Jaén, Campus Las Lagunillas, Jaén, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Altarejos
authors.affiliation: Department of Anatomy, Histology and Embryology, Semmelweis University, Tűzoltó street 58, Budapest, Hungary.
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Fehér
authors.affiliation: Central Laboratory Pest, Semmelweis University, Nagyvárad square 4, Budapest, Hungary.
authors.forename: Ibolya
authors.initials: I
authors.lastname: Kocsis
authors.affiliation: Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, P.O. Box 286, Budapest, Hungary.
authors.forename: Klára
authors.initials: K
authors.lastname: Szentmihályi
authors.affiliation: Department of Applied Chemistry, Faculty of Food Science, Corvinus University of Budapest, Villányi street 29-43, Budapest, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Abrankó
authors.affiliation: Department of Genetics and Plant Breeding, Faculty of Horticultural Science, Corvinus University of Budapest, Villányi street 29-43, Budapest, Hungary. hegedus.vers@gmail.com.
authors.forename: Attila
authors.initials: A
authors.lastname: Hegedűs
authors.affiliation: Department of Applied Chemistry, Faculty of Food Science, Corvinus University of Budapest, Villányi street 29-43, Budapest, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Stefanovits-Bányai
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000032:analysis; D000975:Antioxidants / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D005419:Flavonoids / Q000032:analysis; D005638:Fruit / Q000737:chemistry*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D059808:Polyphenols / Q000032:analysis*; D000068220:Prunus avium / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D005419:Flavonoids; D000960:Hypolipidemic Agents; D059808:Polyphenols; D002784:Cholesterol
keywords: HPLC-DAD/ESI-MS analysis; Lipid lowering effect; Polyphenol; Sour cherry