title: Effect of exercise on markers of vascular health in renal transplant recipients.
abstract: The cornerstone of cardiovascular risk management is lifestyle intervention including exercise which could exert favorable impact also in renal transplant recipients. Nevertheless, reliable assessment of the effect of lifestyle interventions is complicated and the available data in this population are not consistent. The aim of the study was to evaluate the effect of physical activity on selected laboratory markers of vascular health including circulating stem cells, endothelial progenitor cells, microparticles, and plasma asymmetric dimethyl arginine in renal transplant recipients. Nineteen men and 7 women were recruited in 6-month program of standardized and supervised exercise. Control group consisted of 23 men and 13 women of similar age and body mass index not included into the program. One year after the transplantation, the main difference between intervention and control group was found in the change of endothelial progenitor cells (p=0.006). Surprisingly, more favorable change was seen in the control group in which endothelial progenitor cells significantly increased compared to the intervention group. The explanation of this finding might be a chronic activation of reparative mechanisms of vascular system in the population exposed to multiple risk factors which is expressed as relatively increased number of endothelial progenitor cells. Therefore, their decrease induced by exercise might reflect stabilization of these processes.
authors.affiliation: Laboratory for Atherosclerosis Research, Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. japi@ikem.cz.
authors.forename: J
authors.initials: J
authors.lastname: Piťha
authors.forename: I
authors.initials: I
authors.lastname: Králová Lesná
authors.forename: P
authors.initials: P
authors.lastname: Stávek
authors.forename: A
authors.initials: A
authors.lastname: Mahrová
authors.forename: J
authors.initials: J
authors.lastname: Racek
authors.forename: A
authors.initials: A
authors.lastname: Sekerková
authors.forename: V
authors.initials: V
authors.lastname: Teplan
authors.forename: M
authors.initials: M
authors.lastname: Štollová
mesh_terms: D000328:Adult; D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D001808:Blood Vessels / Q000502:physiology*; D055252:Cell-Derived Microparticles; D066026:Endothelial Progenitor Cells; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: C487735:dimethylarginine; D001120:Arginine