title: Adaptations of skeletal muscle mitochondria to exercise training.
abstract: Mitochondrial volume density (Mito(VD)) is composed of two distinct mitochondrial subpopulations--intermyofibrillar mitochondria (Mito(IMF)) and subsarcolemmal mitochondria (Mito(SS)). With exercise training, Mito(VD) may increase by up to 40% and is, for the most part, related to an increase in Mito(IMF). Exercise-induced adaptations in mitochondrial function depend on the intensity of training and appear to be explained predominately by an increased expression of mitochondrial enzymes that facilitate aerobic metabolism. Although mitochondrial content often increases with training, it seems that mitochondrial adaptations are not needed to facilitate maximal oxygen uptake, whereas such adaptations are of greater importance for endurance capacity.
authors.affiliation: Zürich Center for Integrative Human Physiology, Institute of Physiology, University of Zürich, Zürich, Switzerland.
authors.forename: Carsten
authors.initials: C
authors.lastname: Lundby
authors.affiliation: Zürich Center for Integrative Human Physiology, Institute of Physiology, University of Zürich, Zürich, Switzerland.|Health and Physical Education, School of Teaching and Learning, Western Carolina University, Cullowhee, NC, USA.|Physical Therapy Department, Western Carolina University, Cullowhee, NC, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Jacobs
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008931:Mitochondria, Muscle / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D064797:Physical Conditioning, Human / Q000502:physiology*