title: Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory.
abstract: While mesenchymal stem cells (MSCs) are rapidly cleared from the body following systemic transplantation, their therapeutic benefits typically persist. In this issue, Liu et al. (2015) reveal that the ability of transplanted MSCs to alleviate osteoporosis in systemic lupus erythematosus is maintained through epigenetic changes conferred by secretory action of the MSCs.
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA; Department of Medicine, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
authors.forename: Kelvin S
authors.initials: KS
authors.lastname: Ng
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA; Department of Medicine, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Kuncewicz
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA; Department of Medicine, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: bwhkarp@gmail.com.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Karp
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D005260:Female; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051881:Receptor, Notch1 / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051881:Receptor, Notch1