title: Linking pattern recognition and salicylic acid responses in Arabidopsis through ACCELERATED CELL DEATH6 and receptors.
abstract: The Arabidopsis membrane protein ACCELERATED CELL DEATH 6 (ACD6) and the defense signal salicylic acid (SA) are part of a positive feedback loop that regulates the levels of at least 2 pathogen-associated molecular patterns (PAMP) receptors, including FLAGELLIN SENSING 2 (FLS2) and CHITIN ELICITOR RECEPTOR (LYSM domain receptor-like kinase 1, CERK1). ACD6- and SA-mediated regulation of these receptors results in potentiation of responses to FLS2 and CERK1 ligands (e.g. flg22 and chitin, respectively). ACD6, FLS2 and CERK1 are also important for callose induction in response to an SA agonist even in the absence of PAMPs. Here, we report that another receptor, EF-Tu RECEPTOR (EFR) is also part of the ACD6/SA signaling network, similar to FLS2 and CERK1.
authors.affiliation: a Department of Molecular Genetics and Cell Biology ; The University of Chicago ; Chicago , IL USA.
authors.forename: Chika
authors.initials: C
authors.lastname: Tateda
authors.affiliation: a Department of Molecular Genetics and Cell Biology ; The University of Chicago ; Chicago , IL USA.
authors.forename: Zhongqin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: a Department of Molecular Genetics and Cell Biology ; The University of Chicago ; Chicago , IL USA.
authors.forename: Jean T
authors.initials: JT
authors.lastname: Greenberg
mesh_terms: D017487:Ankyrins / Q000378:metabolism*; D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D016923:Cell Death; D060467:Disease Resistance; D005936:Glucans / Q000378:metabolism; D010935:Plant Diseases; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D020156:Salicylic Acid / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C480953:ACD6 protein, Arabidopsis; D017487:Ankyrins; D029681:Arabidopsis Proteins; C545106:EFR protein, Arabidopsis; D005936:Glucans; D051192:Receptors, Pattern Recognition; C048306:callose; D011494:Protein Kinases; C411853:FLS2 protein, Arabidopsis; C525882:CERK1 protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases; D020156:Salicylic Acid
keywords: ACCELERATED CELL DEATH 6 (ACD6); EF-TU RECEPTOR (EFR); callose; pathogen-associated molecular patterns (PAMPs); plant defense, salicylic acid (SA)