title: Characteristics of coronary artery lesion in patients with and without diabetes mellitus.
abstract: OBJECTIVE
  The goal of this study was to compare the coronary atherosclerotic burden in patients with and without type-2 diabetes by using CT coronary angiography (CTCA).
  
  
  METHODS
  A total of 206 diabetic (mean age 67 ± 11 years; male: 136) and 523 non-diabetic patients (mean age 62 ± 13 years; male: 323) without history of coronary artery disease (CAD) underwent CTCA. The per-patient number of diseased coronary segments was determined, and each diseased segment was classified as showing obstructive lesion (luminal narrowing >50 %) or not. Coronary angiography was then performed to confirm diagnosis.
  
  
  RESULTS
  Diabetics showed a higher rate of abnormal CAD (76 vs. 53 % of patients; p < 0.0001) and fewer normal coronary arteries (24 vs. 47 %; p < 0.0001) compared with non-diabetics. Multi-vessel disease was seen more frequently in patients with diabetes than in patients without diabetes [15 % (n = 22) vs. 7 % (n = 62), respectively; p = 0.0004]. The per-patient number of segments with plaque (4.5 vs. 2.0, respectively; p < 0.0001) and the number of segments with obstructive disease (0.9 vs. 0.5, respectively; p = 0.0001) were higher for diabetic patients than for non-diabetic patients.
  
  
  CONCLUSIONS
  Diabetes was associated with higher coronary plaque burden.
authors.affiliation: VIP Department of Cardiovascular Medicine, Affiliated Beijing Anzhen Hospital of Capital Medical University, Beijing, 100029, People's Republic of China.
authors.forename: S
authors.initials: S
authors.lastname: Jia
authors.affiliation: VIP Department of Cardiovascular Medicine, Affiliated Beijing Anzhen Hospital of Capital Medical University, Beijing, 100029, People's Republic of China. sjshcn@163.com.
authors.forename: S
authors.initials: S
authors.lastname: Mi
authors.affiliation: VIP Department of Cardiovascular Medicine, Affiliated Beijing Anzhen Hospital of Capital Medical University, Beijing, 100029, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: VIP Department of Cardiovascular Medicine, Affiliated Beijing Anzhen Hospital of Capital Medical University, Beijing, 100029, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Zheng
authors.affiliation: VIP Department of Cardiovascular Medicine, Affiliated Beijing Anzhen Hospital of Capital Medical University, Beijing, 100029, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Yang
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D014057:Tomography, X-Ray Computed
keywords: CT coronary angiography; Coronary artery disease; Diabetes mellitus