title: [Effect of Heroin on DLG4 Expression in Hippocampus, Amygdala and Frontal Cortex of Rats].
abstract: OBJECTIVE
  To observe the expression of discs large homolog 4 (DLG4) protein in hippocampus, amygdala and frontal cortex of rats and evaluate postsynaptic density in heroin dependence.
  
  
  METHODS
  The rat heroin dependent model was established by increasing intraperitoneal injection of heroin. DLG4 proteins in hippocampus, amygdala and frontal cortex of heroin dependent 9, 18, 36 days rats were detected with immunohistochemical staining and compared with that in the control group.
  
  
  RESULTS
  DLG4 proteins in hippocampus, amygdala and frontal cortex were gradually reduced with extension of heroin dependent time.
  
  
  CONCLUSIONS
  Heroin dependence can affect postsynaptic density of hippocampus, amygdala and frontal cortex. The changes become more apparent with extension of heroin dependence time.
authors.forename: Liang-ming
authors.initials: LM
authors.lastname: Luo
authors.forename: Qun
authors.initials: Q
authors.lastname: Gong
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Liu
authors.forename: Ming-quan
authors.initials: MQ
authors.lastname: Zhao
authors.forename: Dong-dong
authors.initials: DD
authors.lastname: Chen
authors.forename: Yao-yao
authors.initials: YY
authors.lastname: Xie
authors.forename: Hua
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000076122:Disks Large Homolog 4 Protein; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D003932:Heroin / Q000494:pharmacology*; D006556:Heroin Dependence; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D051381:Rats
chemical_list: D000076122:Disks Large Homolog 4 Protein; C501449:Dlg4 protein, rat; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D003932:Heroin