title: The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production.
abstract: The term regulatory B cells (B regs) is ascribed to a heterogeneous population of B cells with the function of suppressing inflammatory responses. They have been described mainly during the last decade in the context of different immune-mediated diseases. Most of the work on B regs has been focused on IL-10-producing B cells. However, B cells can exert regulatory functions independently of IL-10 production. Here we discuss the phenotypes, development and effector mechanisms of B regs and advances in their role in autoimmunity, infections and cancer.
authors.affiliation: Centro de Investigaciones en Bioquímica Clínica e Inmunología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Melisa
authors.initials: M
authors.lastname: Gorosito Serrán
authors.affiliation: Centro de Investigaciones en Bioquímica Clínica e Inmunología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Facundo
authors.initials: F
authors.lastname: Fiocca Vernengo
authors.affiliation: Centro de Investigaciones en Bioquímica Clínica e Inmunología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Cristian G
authors.initials: CG
authors.lastname: Beccaria
authors.affiliation: Centro de Investigaciones en Bioquímica Clínica e Inmunología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Eva V
authors.initials: EV
authors.lastname: Acosta Rodriguez
authors.affiliation: Centro de Investigaciones en Bioquímica Clínica e Inmunología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Carolina L
authors.initials: CL
authors.lastname: Montes
authors.affiliation: Centro de Investigaciones en Bioquímica Clínica e Inmunología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: agruppi@fcq.unc.edu.ar.
authors.forename: Adriana
authors.initials: A
authors.lastname: Gruppi
mesh_terms: D000818:Animals; D015551:Autoimmunity; D060151:B-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000276:immunology*; D016753:Interleukin-10 / Q000096:biosynthesis*; D009369:Neoplasms / Q000276:immunology*
chemical_list: D016753:Interleukin-10
keywords: Immunoregulation; Regulatory B cell (B reg)