title: Differences in Metabolic Programming Define the Site of Breast Cancer Cell Metastasis.
abstract: Although metabolic reprogramming is a hallmark of oncogenic transformation and growth of primary tumor cells, little is known about how metabolic alterations impact metastasis. In this issue of Cell Metabolism, Dupuy et al. (2015) show that primary breast cancer cells display metabolic heterogeneity, and that their distinct metabolic programs define their sites of metastasis.
authors.affiliation: Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
authors.forename: Heike
authors.initials: H
authors.lastname: Döppler
authors.affiliation: Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: storz.peter@mayo.edu.
authors.forename: Peter
authors.initials: P
authors.lastname: Storz
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D060847:Metabolic Engineering; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D017346:Protein Serine-Threonine Kinases