title: Translating depression biomarkers for improved targeted therapies.
abstract: Mood disorders are among the most common medical conditions and cause amongst the greatest disease burden. Currently approved antidepressants target monoamine pathways; these medicines take many weeks to relieve symptoms, and most patients do not have sustained responses. This review will highlight recent advances in translational science identifying dysfunctional biochemical processes and neuronal circuits associated with mood disorders. We will also summarize strategies for targeting these pathways and for enhancing synaptic plasticity to develop most effective and rapidly acting antidepressant therapies.
authors.affiliation: Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210 Merryfield Row, San Diego, CA 92121, United States. Electronic address: dbredt@its.jnj.com.
authors.forename: David S
authors.initials: DS
authors.lastname: Bredt
authors.affiliation: Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210 Merryfield Row, San Diego, CA 92121, United States.
authors.forename: Maura L
authors.initials: ML
authors.lastname: Furey
authors.affiliation: Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210 Merryfield Row, San Diego, CA 92121, United States.
authors.forename: Guang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210 Merryfield Row, San Diego, CA 92121, United States.
authors.forename: Tim
authors.initials: T
authors.lastname: Lovenberg
authors.affiliation: Neuroscience at Janssen Pharmaceutical Companies of Johnson & Johnson, 1125 Trenton Harbourton Rd, Titusville, NJ 08560, United States.
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Drevets
authors.affiliation: Neuroscience at Janssen Pharmaceutical Companies of Johnson & Johnson, 1125 Trenton Harbourton Rd, Titusville, NJ 08560, United States.
authors.forename: Husseini K
authors.initials: HK
authors.lastname: Manji
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis*; D003863:Depression / Q000188:drug therapy*; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D015415:Biomarkers
keywords: Biomarker; Bipolar; Depression; Glutamate; Imaging; Mood; Neuropharmacology; Synaptic plasticity