title: Combined application of ultrasound and SPECT/CT has incremental value in detecting parathyroid tissue in SHPT patients.
abstract: OBJECTIVE
  The goal of this study is to investigate whether combined application of ultrasound and 99mTc-sestamibi SPECT/CT had the incremental value in accurately detecting parathyroid tissue in patients with SHPT over either method alone.
  
  
  METHODS
  Sixty patients with SHPT on hemodialysis were evaluated preoperatively with parathyroid 99mTc-sestamibi SPECT/CT scintigraphy and ultrasound prior to parathyroidectomy. The sensitivity, specificity and accuracy of 99mTc-sestamibi SPECT/CT scintigraphy, ultrasound and combined application were determined respectively.
  
  
  RESULTS
  The sensitivity, specificity and accuracy of ultrasound were 81% (155/192), 47% (17/36) and 82% (172/228), respectively. The sensitivity, specificity and accuracy of 99mTc-sestamibi SPECT/CT were 85% (163/192), 58% (21/36) and 89% (184/228) respectively. The accuracy of 99mTc-sestamibi SPECT/CT in the diagnosis of parathyroid tissue in patients with SHPT is significantly higher than that of ultrasound. The sensitivity, specificity and accuracy of combined application of ultrasound and 99mTc-sestamibi SPECT/CT were 93% (178/192), 61% (22/36) and 97% (200/228). The sensitivity, specificity and accuracy of combined application of ultrasound and 99mTc-sestamibi SPECT/CT were higher than those of either ultrasound or 99mTc-sestamibi SPECT/CT.
  
  
  CONCLUSIONS
  The combined application of ultrasound and 99mTc-sestamibi SPECT/CT had incremental value in accurately detecting parathyroid tissue in patients with SHPT over either method alone.
authors.affiliation: Capital Medical University, Beijing Friendship Hospital, Department of Nuclear Medicine, 95, Yong An Road, Xi Cheng district, 100050 Beijing, People's Republic of China.
authors.forename: L L
authors.initials: LL
authors.lastname: Yuan
authors.affiliation: Capital Medical University, Beijing Friendship Hospital, Department of Nuclear Medicine, 95, Yong An Road, Xi Cheng district, 100050 Beijing, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Kan
authors.affiliation: Capital Medical University, Beijing Friendship Hospital, Radiology Department, 95, Yong An Road, Xi Cheng district, 100050 Beijing, People's Republic of China. Electronic address: 2428726601@qq.com.
authors.forename: D Q
authors.initials: DQ
authors.lastname: Ma
authors.affiliation: Capital Medical University, Beijing Friendship Hospital, Department of Nuclear Medicine, 95, Yong An Road, Xi Cheng district, 100050 Beijing, People's Republic of China. Electronic address: 13681221974@163.com.
authors.forename: J G
authors.initials: JG
authors.lastname: Yang
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging*; D008297:Male; D064847:Multimodal Imaging; D019275:Radiopharmaceuticals; D000072098:Single Photon Emission Computed Tomography Computed Tomography; D017256:Technetium Tc 99m Sestamibi; D014463:Ultrasonography
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
keywords: 99mTc-sestamibi; Chronic kidney disease; SPECT/CT; Secondary hyperparathyroidism; Ultrasound