title: Genome-wide association study identifies multiple susceptibility loci for glioma.
abstract: Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10(-9)) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10(-8)), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10(-11)), 12q21.2 (rs12230172, P=7.53 × 10(-11)) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10(-9)). Our findings provide further insights into the genetic basis of the different glioma subtypes.
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
authors.forename: Ben
authors.initials: B
authors.lastname: Kinnersley
authors.affiliation: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, F-75013 Paris, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Labussière
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
authors.forename: Amy
authors.initials: A
authors.lastname: Holroyd
authors.affiliation: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, F-75013 Paris, France.|Onconeurotek, F-75013 Paris, France.|AP-HP, GH Pitié-Salpêtrière, Service de Neurologie 2, F-75013 Paris, France.
authors.forename: Anna-Luisa
authors.initials: AL
authors.lastname: Di Stefano
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
authors.forename: Jayaram
authors.initials: J
authors.lastname: Vijayakrishnan
authors.affiliation: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, F-75013 Paris, France.|Onconeurotek, F-75013 Paris, France.|AP-HP, GH Pitié-Salpêtrière, Laboratoire de neuropathologie R Escourolle, F-75013 Paris, France.
authors.forename: Karima
authors.initials: K
authors.lastname: Mokhtari
authors.affiliation: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, F-75013 Paris, France.|Onconeurotek, F-75013 Paris, France.|AP-HP, GH Pitié-Salpêtrière, Service de Neurologie 2, F-75013 Paris, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Delattre
authors.affiliation: Department of Neurosurgery, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53105 Bonn, Germany.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Gousias
authors.affiliation: Department of Neurosurgery, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53105 Bonn, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schramm
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
authors.forename: Minouk J
authors.initials: MJ
authors.lastname: Schoemaker
authors.affiliation: Centre for Epidemiology and Biostatistics, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Fleming
authors.affiliation: Department of Biomedicine, Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany.|Division of Medical Genetics, Department of Biomedicine, University of Basel, 4056 Basel, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Herms
authors.affiliation: Department of Biomedicine, Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Heilmann
authors.affiliation: 1st Medical Department, University Clinic Schleswig-Holstein, Campus Kiel, House 6, Arnold-Heller-Straße 3, Kiel 24105, Germany.|Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Arnold-Heller-Straße 3, Kiel 24105, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
authors.forename: Heinz-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.affiliation: Department of Biomedicine, Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany.
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.|Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
authors.forename: Anthony
authors.initials: A
authors.lastname: Swerdlow
authors.affiliation: AP-HP, GH Pitié-Salpêtrière, Laboratoire de neuropathologie R Escourolle, F-75013 Paris, France.|Foundation Jean Dausset-CEPH, 27 Rue Juliette Dodu, 75010 Paris, France.|Génome Québec, Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3A 0G1.
authors.forename: Mark
authors.initials: M
authors.lastname: Lathrop
authors.affiliation: Department of Neurosurgery, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53105 Bonn, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Simon
authors.affiliation: Division of Hematology-Oncology, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Bondy
authors.affiliation: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, F-75013 Paris, France.|Onconeurotek, F-75013 Paris, France.|AP-HP, GH Pitié-Salpêtrière, Service de Neurologie 2, F-75013 Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Sanson
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D005910:Glioma / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged