title: Association Study of Matrix Metalloproteinases Gene Polymorphisms with Susceptibility to Rheumatoid Arthritis: A Meta-Analysis.
abstract: OBJECTIVE
  Association of matrix metalloproteinases (MMPs) gene polymorphisms with rheumatoid arthritis is controversial. We conduct a meta-analysis to clarify this dispute.
  
  
  METHODS
  We systematically searched the electronic PUBMED, EMBASE and CNKI databases for research articles about MMPs (MMP-1, MMP-2, MMP-3, MMP-9) gene polymorphisms and rheumatoid arthritis (RA) up to January 2015. According to the heterogeneity, fixed-effects or random-effects models were used to calculate crude odds ratios (ORs) and 95% confidence intervals (95% CIs).
  
  
  RESULTS
  A total of 11 articles involving 2143 cases and 2049 controls were included in this meta-analysis. Overall, no significant associations were observed between MMP-1-1607 1G/2G polymorphism and RA. Stratification by ethnicity, no significant associations were observed in Caucasian populations. Similarly, no significant associations were observed between MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms and RA in overall and Caucasian populations, respectively. However, a weak association was found between MMP-2-1306 C/T polymorphism and RA (C vs. T, OR = 0.813, 95%CI = 0.694-0.953, p = 0.010) in overall populations.
  
  
  CONCLUSIONS
  The present meta-analysis suggests that MMP-1-1607 1G/2G, MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms are not associated with the susceptibility of RA, but MMP-2 -1306 C/T is weakly associated with susceptibility to RA. Further studies with more sample size are needed for definitive conclusions.
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , PR China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University , Hefei , Anhui , PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , PR China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University , Hefei , Anhui , PR China.
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Tao
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , PR China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University , Hefei , Anhui , PR China.
authors.forename: Meng-Qin
authors.initials: MQ
authors.lastname: Zhao
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , PR China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University , Hefei , Anhui , PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , PR China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University , Hefei , Anhui , PR China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , PR China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University , Hefei , Anhui , PR China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , PR China and.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University , Hefei , Anhui , PR China.
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
chemical_list: D020782:Matrix Metalloproteinases
keywords: Matrix metalloproteinase; meta-analysis; polymorphism; rheumatoid arthritis; susceptibility