title: Aggregation-Induced-Emissive Molecule Incorporated into Polymeric Nanoparticulate as FRET Donor for Observing Doxorubicin Delivery.
abstract: Tetraphenylethene (TPE) derivatives characterized with distinct aggregation-induced-emission, attempted to aggregate with doxorubicin (Dox) to formulate the interior compartment of polymeric nanoparticulate, served as fluorescence resonance energy transfer (FRET) donor to promote emission of acceptor Dox. Accordingly, this FRET formulation allowed identification of Dox in complexed form by detecting FRET. Important insight into the Dox releasing can be subsequently explored by extracting complexed Dox (FRET) from the overall Dox via direct single-photon excitation of Dox. Of note, functional catiomers were used to complex with FRET partners for a template formulation, which was verified to induce pH-responsive release in the targeted subcellular compartment. Hence, this well-defined multifunctional system entitles in situ observation of the drug releasing profile and insight on drug delivery journey from the tip of injection vein to the subcellular organelle of the targeted cells.
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , Tianjin 300384, China.
authors.forename: Xiongqi
authors.initials: X
authors.lastname: Han
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , Tianjin 300384, China.
authors.forename: De-E
authors.initials: DE
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , Tianjin 300384, China.
authors.forename: Tieyan
authors.initials: T
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , Tianjin 300384, China.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Lu
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , Tianjin 300384, China.
authors.forename: Jianbiao
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Qixian
authors.initials: Q
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology , Tianjin 300384, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
mesh_terms: D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005030:Ethylenes / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000737:chemistry
chemical_list: D005030:Ethylenes; D011108:Polymers; D004317:Doxorubicin; C036216:ethylene
keywords: FRET; aggregation-induced-emission; poly(glycerol methacrylate) (PGMA); tetraphenylethene (TPE); tumor target; two-photon excitation