title: The Effect of a Golden Hour Policy on the Morbidity and Mortality of Combat Casualties.
abstract: OBJECTIVE
  The term golden hour was coined to encourage urgency of trauma care. In 2009, Secretary of Defense Robert M. Gates mandated prehospital helicopter transport of critically injured combat casualties in 60 minutes or less.
  
  
  OBJECTIVE
  To compare morbidity and mortality outcomes for casualties before vs after the mandate and for those who underwent prehospital helicopter transport in 60 minutes or less vs more than 60 minutes.
  
  
  METHODS
  A retrospective descriptive analysis of battlefield data examined 21,089 US military casualties that occurred during the Afghanistan conflict from September 11, 2001, to March 31, 2014. Analysis was conducted from September 1, 2014, to January 21, 2015.
  
  
  METHODS
  Data for all casualties were analyzed according to whether they occurred before or after the mandate. Detailed data for those who underwent prehospital helicopter transport were analyzed according to whether they occurred before or after the mandate and whether they occurred in 60 minutes or less vs more than 60 minutes. Casualties with minor wounds were excluded. Mortality and morbidity outcomes and treatment capability-related variables were compared.
  
  
  RESULTS
  For the total casualty population, the percentage killed in action (16.0% [386 of 2411] vs 9.9% [964 of 9755]; P < .001) and the case fatality rate ([CFR] 13.7 [469 of 3429] vs 7.6 [1344 of 17,660]; P < .001) were higher before vs after the mandate, while the percentage died of wounds (4.1% [83 of 2025] vs 4.3% [380 of 8791]; P = .71) remained unchanged. Decline in CFR after the mandate was associated with an increasing percentage of casualties transported in 60 minutes or less (regression coefficient, -0.141; P < .001), with projected vs actual CFR equating to 359 lives saved. Among 4542 casualties (mean injury severity score, 17.3; mortality, 10.1% [457 of 4542]) with detailed data, there was a decrease in median transport time after the mandate (90 min vs 43 min; P < .001) and an increase in missions achieving prehospital helicopter transport in 60 minutes or less (24.8% [181 of 731] vs 75.2% [2867 of 3811]; P < .001). When adjusted for injury severity score and time period, the percentage killed in action was lower for those critically injured who received a blood transfusion (6.8% [40 of 589] vs 51.0% [249 of 488]; P < .001) and were transported in 60 minutes or less (25.7% [205 of 799] vs 30.2% [84 of 278]; P < .01), while the percentage died of wounds was lower among those critically injured initially treated by combat support hospitals (9.1% [48 of 530] vs 15.7% [86 of 547]; P < .01). Acute morbidity was higher among those critically injured who were transported in 60 minutes or less (36.9% [295 of 799] vs 27.3% [76 of 278]; P < .01), those severely and critically injured initially treated at combat support hospitals (severely injured, 51.1% [161 of 315] vs 33.1% [104 of 314]; P < .001; and critically injured, 39.8% [211 of 530] vs 29.3% [160 of 547]; P < .001), and casualties who received a blood transfusion (50.2% [618 of 1231] vs 3.7% [121 of 3311]; P < .001), emphasizing the need for timely advanced treatment.
  
  
  CONCLUSIONS
  A mandate made in 2009 by Secretary of Defense Gates reduced the time between combat injury and receiving definitive care. Prehospital transport time and treatment capability are important factors for casualty survival on the battlefield.
authors.affiliation: Joint Trauma System, United States Army Institute of Surgical Research, Joint Base San Antonio-Ft Sam Houston, Texas2Uniformed Services University of the Health Sciences, Bethesda, Maryland3Texas A&M Health Science Center College of Medicine, College Stat.
authors.forename: Russ S
authors.initials: RS
authors.lastname: Kotwal
authors.affiliation: Joint Trauma System, United States Army Institute of Surgical Research, Joint Base San Antonio-Ft Sam Houston, Texas.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Howard
authors.affiliation: Joint Trauma System, United States Army Institute of Surgical Research, Joint Base San Antonio-Ft Sam Houston, Texas.
authors.forename: Jean A
authors.initials: JA
authors.lastname: Orman
authors.affiliation: Joint Trauma System, United States Army Institute of Surgical Research, Joint Base San Antonio-Ft Sam Houston, Texas.
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Tarpey
authors.affiliation: Joint Trauma System, United States Army Institute of Surgical Research, Joint Base San Antonio-Ft Sam Houston, Texas2Uniformed Services University of the Health Sciences, Bethesda, Maryland.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Bailey
authors.affiliation: Uniformed Services University of the Health Sciences, Bethesda, Maryland.
authors.forename: Howard R
authors.initials: HR
authors.lastname: Champion
authors.affiliation: Joint Trauma System, United States Army Institute of Surgical Research, Joint Base San Antonio-Ft Sam Houston, Texas.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Mabry
authors.affiliation: Center for Translational Injury Research, The University of Texas Medical School at Houston.
authors.forename: John B
authors.initials: JB
authors.lastname: Holcomb
authors.affiliation: Joint Trauma System, United States Army Institute of Surgical Research, Joint Base San Antonio-Ft Sam Houston, Texas2Uniformed Services University of the Health Sciences, Bethesda, Maryland.
authors.forename: Kirby R
authors.initials: KR
authors.lastname: Gross
mesh_terms: D000328:Adult; D055826:Afghan Campaign 2001-; D017732:Air Ambulances / Q000706:statistics & numerical data*; D001803:Blood Transfusion / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008887:Military Medicine; D008889:Military Personnel / Q000706:statistics & numerical data*; D016134:Organizational Policy; D012189:Retrospective Studies; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D014947:Wounds and Injuries / Q000401:mortality* / Q000628:therapy