title: Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma.
abstract: The morphology of the pathognomonic Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma was described over a century ago, yet it was only relatively recently that the B-cell origin of these cells was identified. In a proportion of cases, HRS cells harbour monoclonal forms of the B lymphotropic Epstein-Barr virus (EBV). This review summarises current knowledge of the pathogenesis of Hodgkin lymphoma with a particular emphasis on the contribution of EBV.
authors.affiliation: School of Cancer Sciences and Centre for Human Virology, College of Medical and Dental Sciences, University of Birmingham, Birmingham, Edgbaston, B15 2TT, UK. P.G.Murray@bham.ac.uk.
authors.forename: Paul
authors.initials: P
authors.lastname: Murray
authors.affiliation: School of Cancer Sciences and Centre for Human Virology, College of Medical and Dental Sciences, University of Birmingham, Birmingham, Edgbaston, B15 2TT, UK. A.I.BELL@bham.ac.uk.
authors.forename: Andrew
authors.initials: A
authors.lastname: Bell
mesh_terms: D000818:Animals; D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology*; D006801:Humans