title: Association of a Human FABP1 Gene Promoter Region Polymorphism with Altered Serum Triglyceride Levels.
abstract: Liver fatty acid-binding protein (L-FABP), also known as fatty acid-binding protein 1 (FABP1), is a key regulator of hepatic lipid metabolism. Elevated FABP1 levels are associated with an increased risk of cardiovascular disease (CVD) and metabolic syndromes. In this study, we examine the association of FABP1 gene promoter variants with serum FABP1 and lipid levels in a Chinese population. Four promoter single-nucleotide polymorphisms (SNPs) of FABP1 gene were genotyped in a cross-sectional survey of healthy volunteers (n = 1,182) from Fuzhou city of China. Results showed that only the rs2919872 G>A variant was significantly associated with serum TG concentration(P = 0.032).Compared with the rs2919872 G allele, rs2919872 A allele contributed significantly to reduced serum TG concentration, and this allele dramatically decreased the FABP1 promoter activity(P < 0.05). The rs2919872 A allele carriers had considerably lower serum FABP1 levels than G allele carriers (P < 0.01). In the multivariable linear regression analysis, the rs2919872 A allele was negatively associated with serum FABP1 levels (β = -0.320, P = 0.003), while serum TG levels were positively associated with serum FABP1 levels (β = 0.487, P = 0.014). Our data suggest that compared with the rs2919872 G allele, the rs2919872 A allele reduces the transcriptional activity of FABP1 promoter, and thereby may link FABP1 gene variation to TG level in humans.
authors.affiliation: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
authors.forename: Xian-E
authors.initials: XE
authors.lastname: Peng
authors.affiliation: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China.
authors.forename: Yun-Li
authors.initials: YL
authors.lastname: Wu
authors.affiliation: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
authors.forename: Yi-Bing
authors.initials: YB
authors.lastname: Zhu
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
authors.forename: Rong-Dong
authors.initials: RD
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou, China.
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Lu
authors.affiliation: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000235:genetics*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; D014280:Triglycerides