title: New drug regimens for HIV in pregnancy and a national strategic plan to manage HIV: A South African perspective.
abstract: In South Africa, new drug regimens (WHO treatment Option B) used to manage HIV infection in pregnancy and the national strategic plan on HIV have resulted in improved health outcomes. Among these outcomes are reductions in the following: mother-to-child transmission (MTCT) of HIV to 2.4%; maternal deaths attributable to HIV; and adverse reactions due to antiretroviral therapy (ART). The present article describes these new drug regimens and the national strategic HIV management plan, as well as their challenges and the implications of improved health outcomes. Such outcomes imply that further decreases in MTCT of HIV, and HIV attributable maternal deaths are possible if potential challenges are addressed and treatment option B+ offered. A confidential enquiry into each case of MTCT is advocated to reduce vertical transmission rates to zero levels.
authors.affiliation: Department of Obstetrics and Gynecology, Edendale Hospital, Pietermaritzburg, and University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Nnabuike C
authors.initials: NC
authors.lastname: Ngene
authors.affiliation: Women's Health and HIV Research Group, University of KwaZulu-Natal, Durban, South Africa. Electronic address: jmog@ukzn.ac.za.
authors.forename: Jagidesa
authors.initials: J
authors.lastname: Moodley
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D009313:National Health Programs / Q000706:statistics & numerical data*; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D013019:South Africa
chemical_list: D019380:Anti-HIV Agents
keywords: Antiretroviral; HIV; Mother-to-child transmission; Pregnancy; South Africa; Strategic planning