title: Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery.
abstract: The outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs targeting cell surface adhesive receptors, receptor tyrosine kinases, and modulation of several molecules of extracellular matrices (ECMs), the complex composite of collagens, glycoproteins, proteoglycans, and glycosaminoglycans that dictates tissue architecture. Cancer tissue invasive processes progress by various oncogenic strategies, including interfering with ECM molecules and their interactions with invasive cells. In this review, we describe how the ECM components, proteoglycans and glycosaminoglycans, influence tumor cell signaling. In particular this review describes how the glycosaminoglycan hyaluronan (HA) and its major receptor CD44 impact invasive behavior of tumor cells, and provides useful insight when designing new therapeutic strategies in the treatment of cancer.
authors.affiliation: Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Suniti
authors.initials: S
authors.lastname: Misra
authors.affiliation: Department of Biomedical Engineering/ND20, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Vincent C
authors.initials: VC
authors.lastname: Hascall
authors.affiliation: Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA.
authors.forename: Ilia
authors.initials: I
authors.lastname: Atanelishvili
authors.affiliation: Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Moreno Rodriguez
authors.affiliation: Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Roger R
authors.initials: RR
authors.lastname: Markwald
authors.affiliation: Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Shibnath
authors.initials: S
authors.lastname: Ghatak