title: Diagnostic performance and radiation dose of lower extremity CT angiography using a 128-slice dual source CT at 80 kVp and high pitch.
abstract: BACKGROUND
  Multi-detector computed tomography (MDCT) angiography is now used for the diagnosing patients with peripheral arterial disease. The dose of radiation is related to variable factors, such as tube current, tube voltage, and helical pitch.
  
  
  OBJECTIVE
  To assess the diagnostic performance and radiation dose of lower extremity CT angiography (CTA) using a 128-slice dual source CT at 80 kVp and high pitch in patients with critical limb ischemia (CLI).
  
  
  METHODS
  Twenty-eight patients (mean, 64.1 years; range, 39-80 years) with CLI were enrolled in this retrospective study and underwent CTA using a 128-slice dual source CT at 80 kVp and high pitch and subsequent intra-arterial digital subtraction angiography (DSA), which was used as a reference standard for assessing diagnostic performance.
  
  
  RESULTS
  For arterial segments with significant disease (>50% stenosis), overall sensitivity, specificity, and accuracy of lower extremity CTA were 94.8% (95% CI, 91.7-98.0%), 91.5% (95% CI, 87.7-95.2%), and 93.1% (95% CI, 90.6-95.6%), respectively, and its positive and negative predictive values were 91.0% (95% CI, 87.1-95.0%), and 95.1% (95% CI, 92.1-98.1%), respectively. Mean radiation dose delivered to lower extremities was 266.6 mGy.cm.
  
  
  CONCLUSIONS
  Lower extremity CTA using a 128-slice dual source CT at 80 kVp and high pitch was found to have good diagnostic performance for the assessment of patients with CLI using an extremely low radiation dose.
authors.affiliation: Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea kschoo0618@naver.com.
authors.forename: Ki Seok
authors.initials: KS
authors.lastname: Choo
authors.affiliation: Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Ung Bae
authors.initials: UB
authors.lastname: Jeon
authors.affiliation: Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Tae Un
authors.initials: TU
authors.lastname: Kim
authors.affiliation: Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Jae Yeon
authors.initials: JY
authors.lastname: Hwang
authors.affiliation: Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Jeong A
authors.initials: JA
authors.lastname: Yeom
authors.affiliation: Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Hee Seok
authors.initials: HS
authors.lastname: Jeong
authors.affiliation: Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Yoon Young
authors.initials: YY
authors.lastname: Choi
authors.affiliation: Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Nam
authors.affiliation: Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Republic of Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Jeong
authors.affiliation: Department of Cardiology, Kim Hae Jungang Hospital, Republic of Korea.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Lim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D000072226:Computed Tomography Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging*; D035002:Lower Extremity / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
keywords: Diagnosis; arteries; lower extremity; multi-detector computed tomography; radiography