title: Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome.
abstract: Long noncoding RNAs (lncRNA) play key roles in regulating autoimmunity and immunity balance. LncRNA TMEVPG1, which is encoded by a gene located near the Ifn gene, contributes to interferon gamma expression. We investigated the expression of TMEVPG1 in patients with Sjögren syndrome (SS) to determine its role in the pathogenesis of SS. In this study, we detected the relative expression of TMEVPG1 in CD4(+) T cells of 25 SS patients and 25 healthy donors. Moreover, the proportion of Th1 cells and T-bet levels was also analyzed. Furthermore, we explored the correlation between the expression of TMEVPG1 and the level of autoantibodies, erythrocyte sedimentation rate (ESR) and IgG in SS patients. Our results indicated that the proportion of Th1 cells and the levels of TMEVPG1 and T-bet were increased in SS patients. In addition, the level of expression of TMEVPG1 was correlated with the level of SSA, ESR and IgG. Our data suggest that upregulation of lncRNA TMEVPG1 may be involved in the pathogenesis of Sjögren syndrome.
authors.affiliation: Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Dianli Road 8, Zhenjiang, 212002, China.|Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Dianli Road 8, Zhenjiang, 212002, China.
authors.forename: Huiyong
authors.initials: H
authors.lastname: Peng
authors.affiliation: Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China. tjj850913@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Dianli Road 8, Zhenjiang, 212002, China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Tang
authors.affiliation: Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Rui
authors.affiliation: Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Tian
authors.affiliation: Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China.
authors.forename: Yungang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Dianli Road 8, Zhenjiang, 212002, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pathology, The University of Hong Kong, Hong Kong, China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Lu
authors.affiliation: Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China.
authors.forename: Huaxi
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Dianli Road 8, Zhenjiang, 212002, China. sjwjs@ujs.edu.cn.|Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China. sjwjs@ujs.edu.cn.
authors.forename: Shengjun
authors.initials: S
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation; D055785:Gene Knockdown Techniques; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D062085:RNA, Long Noncoding / Q000235:genetics*; D012859:Sjogren's Syndrome / Q000235:genetics* / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D001323:Autoantibodies; D062085:RNA, Long Noncoding
keywords: Long noncoding RNA; Sjögren syndrome; T helper type 1 cells; TMEVPG1