title: Expansile crosslinked polymersomes for pH sensitive delivery of doxorubicin.
abstract: We report a new crosslinked polymersome with pH-responsive swelling properties through acidic hydrolysis of hydrophobic contents from the amphiphilic polymer chains. Its unique stability under physiological conditions and large swelling capability under low pH conditions give this polymersome promising potential for anticancer drug delivery.
authors.affiliation: Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA. Lu.Lichun@mayo.edu and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Xifeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA. Lu.Lichun@mayo.edu and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Yaszemski
authors.affiliation: Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA. Lu.Lichun@mayo.edu and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Lichun
authors.initials: L
authors.lastname: Lu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics; D002470:Cell Survival; D004317:Doxorubicin / Q000737:chemistry* / Q000494:pharmacology*; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011108:Polymers; D004317:Doxorubicin