title: N-Heterocyclic Carbene-Catalyzed Activation of Esters of N-Hydroxyphthalimide: A Highly Enantioselective Route to Chiral Dihydropyridinones Bearing an All Carbon Quaternary Stereogenic Center.
abstract: An N-heterocyclic carbene-catalyzed highly enantioselective [3 + 3] annulation reaction of N-hydroxyphthalimide (NHPI) 3,3-disubstituted acrylates and N-Ts ketimines was developed. In most cases, the desired chiral dihydropyridinone products bearing an all carbon quaternary stereogenic center could be obtained in good yields with excellent enantioselectivities (>99% ee's), which demonstrated the NHPI acrylates as a kind of excellent substrate in NHC-catalysis.
authors.affiliation: College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University , Hangzhou 310036, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University , Hangzhou 310036, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zeng
authors.affiliation: College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University , Hangzhou 310036, China.
authors.forename: Danbo
authors.initials: D
authors.lastname: Xie
authors.affiliation: College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University , Hangzhou 310036, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Chen
authors.affiliation: College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University , Hangzhou 310036, China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Ding
authors.affiliation: College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University , Hangzhou 310036, China.
authors.forename: Anna
authors.initials: A
authors.lastname: Wang
authors.affiliation: College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University , Hangzhou 310036, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Yang
authors.affiliation: College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University , Hangzhou 310036, China.
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhong