title: Crawling with Virus: Translational Insights from a Neonatal Mouse Model on the Pathogenesis of Respiratory Syncytial Virus in Infants.
abstract: The infant immune response to respiratory syncytial virus (RSV) remains incompletely understood. Here we review the use of a neonatal mouse model of RSV infection to mimic severe infection in human infants. We describe numerous age-specific responses, organized by cell type, observed in RSV-infected neonatal mice and draw comparisons (when possible) to human infants.
authors.affiliation: Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
authors.forename: Dahui
authors.initials: D
authors.lastname: You
authors.affiliation: Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
authors.forename: Jordy
authors.initials: J
authors.lastname: Saravia
authors.affiliation: Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
authors.forename: David
authors.initials: D
authors.lastname: Siefker
authors.affiliation: Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
authors.forename: Bishwas
authors.initials: B
authors.lastname: Shrestha
authors.affiliation: Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee, USA scormier@uthsc.edu.
authors.forename: Stephania A
authors.initials: SA
authors.lastname: Cormier
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions; D006801:Humans; D051379:Mice; D018357:Respiratory Syncytial Virus Infections / Q000473:pathology* / Q000821:virology*; D012136:Respiratory Syncytial Viruses / Q000502:physiology*