title: In Brief: Endothelial-to-mesenchymal transition.
abstract: Recent evidence has highlighted the role of endothelial-to-mesenchymal transition (EndoMT) in the onset and progression of a number of human pathologies. EndoMT involves the loss of an endothelial signature to generate unspecialized mesenchymal-like cells, susceptible to being re-differentiated into mesodermal cell types, including osteoblasts, chondrocytes, and adipocytes. Therefore, modulation of the molecular pathways controlling EndoMT can be considered as a therapeutic approach for particular human diseases. In addition, EndoMT may be harnessed for tissue engineering by producing multipotent mesenchymal cells able to differentiate into mutiple cell types.
authors.affiliation: Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden University Medical Center, The Netherlands.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Sanchez-Duffhues
authors.affiliation: Department of Anatomy and Embryology, Leiden University Medical Center, The Netherlands.
authors.forename: Valeria
authors.initials: V
authors.lastname: Orlova
authors.affiliation: Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden University Medical Center, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Ten Dijke
mesh_terms: D000818:Animals; D054338:Cell Transdifferentiation / Q000502:physiology*; D042783:Endothelial Cells / Q000473:pathology*; D006801:Humans; D008648:Mesoderm / Q000473:pathology*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
chemical_list: D016212:Transforming Growth Factor beta; D051176:beta Catenin
keywords: EndoMT; TGF-β; endothelial cell; β-catenin