title: Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines.
abstract: The anti-tumor activity of imidazolium salts is highly dependent upon the substituents on the nitrogen atoms of the imidazolium cation. We have synthesized and characterized a series of naphthalene-substituted imidazolium salts and tested them against a variety of non-smallcell lung cancer cell lines. Several of these complexes displayed anticancer activity comparable to cisplatin. These compounds induced apoptosis in the NCI-H460 cell line as determined by Annexin V staining, caspase-3, and PARP cleavage. These results strongly suggest that this class of compounds can serve as potent chemotherapeutic agents.
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Wright
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Deblock
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Patrick O
authors.initials: PO
authors.lastname: Wagers
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Ernest
authors.initials: E
authors.lastname: Duah
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Nikki K
authors.initials: NK
authors.lastname: Robishaw
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Kerri L
authors.initials: KL
authors.lastname: Shelton
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Marie R
authors.initials: MR
authors.lastname: Southerland
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: DeBord
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Kortney M
authors.initials: KM
authors.lastname: Kersten
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Lucas J
authors.initials: LJ
authors.lastname: McDonald
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Stiel
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Panzner
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Claire A
authors.initials: CA
authors.lastname: Tessier
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Sailaja
authors.initials: S
authors.lastname: Paruchuri
authors.affiliation: Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Wiley J
authors.initials: WJ
authors.lastname: Youngs
keywords: Anti-tumor; Anticancer; Apoptosis; Imidazolium cation; Imidazolium salt