title: Osteoporosis and sarcopenia: two diseases or one?
abstract: OBJECTIVE
  This article reviews recently published evidence for common pathways explaining bone and muscle wasting in normal ageing and pathological conditions.
  
  
  RESULTS
  Numerous studies support the concept of a bone-muscle unit, where constant cross-talking between the two tissues takes place, involving molecules released by the skeletal muscle secretome, which affects bone, and osteokines secreted by the osteoblasts and osteocytes, which, in turn, impact muscle cells.
  
  
  CONCLUSIONS
  New chemical entities aiming at concomitantly treating osteoporosis and sarcopenia could be developed by targeting pathways that centrally regulate bone and muscle or emerging pathways that facilitate the communication between the two tissues.
authors.affiliation: aDepartment of Public Health, Epidemiology and Health Economics bSupport Unit in Epidemiology and Biostatistics, University of Liège, Liège, Belgium.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Reginster
authors.forename: Charlotte
authors.initials: C
authors.lastname: Beaudart
authors.forename: Fanny
authors.initials: F
authors.lastname: Buckinx
authors.forename: Olivier
authors.initials: O
authors.lastname: Bruyère
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D010006:Osteoblasts / Q000378:metabolism*; D010024:Osteoporosis / Q000188:drug therapy / Q000378:metabolism*; D019899:Paracrine Communication; D055948:Sarcopenia / Q000188:drug therapy / Q000378:metabolism*; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D006728:Hormones; D014807:Vitamin D