title: Therapeutic Targeting of microRNAs in Cancer: Future Perspectives.
abstract: Preclinical Research The discovery of microRNAs (miRNAs) and their link with cancer has opened a new era in cancer therapeutics. Approximately, 18 - 24 nucleotides long, miRNAs can up-regulate or down-regulate gene expression in many cancer types and are respectively categorized as oncogenes (oncomirs) or tumor suppressors. Expression profiles of miRNAs with biomarker potential can be used for the classification, diagnosis, therapeutic treatment, and prognosis of different cancer types. miRNA mimics and miRNA antagonists are the two main approaches to miRNA-based cancer therapies that respectively inhibit oncomirs or restore the expression of tumor suppressive miRNAs. This review serves to provide some general insight into miRNA biogenesis, cancer related miRNAs, and miRNA therapeutics.
authors.affiliation: Faculty of Science and Letters, Department of Biology, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey.
authors.forename: Lütfi
authors.initials: L
authors.lastname: Tutar
authors.affiliation: Graduate School of Natural and Applied Sciences, Department of Bioengineering and Sciences, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey.
authors.forename: Esen
authors.initials: E
authors.lastname: Tutar
authors.affiliation: Faculty of Natural Sciences and Engineering, Department of Bioengineering, Gaziosmanpasa University, Tokat, Turkey.
authors.forename: Aykut
authors.initials: A
authors.lastname: Özgür
authors.affiliation: Faculty of Pharmacy, Department of Basic Sciences, Division of Biochemistry, Cumhuriyet University, Sivas, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tutar
mesh_terms: D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000819:agonists / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000187:drug effects*; D058990:Molecular Targeted Therapy / Q000639:trends; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: cancer; microRNA; oncomir; therapeutics; tumor suppressor