title: Cutaneous and pleural involvement in a patient with multiple myeloma.
abstract: Multiple myeloma (MM) is a malignant proliferation of a single clone of plasma cells and an excess of monoclonal immunoglobulin production. It is rarely associated with cutaneous and pleural involvement. We report a new case of a 62-year-old woman with a history of a symptomatic MM. Three months after chemotherapy initiation, she presented with subcutaneous nodules. Ultrasound-guided needle biopsy confirmed the diagnosis of cutaneous plasmacytomas. She underwent local radiation therapy leading to complete regression of subcutaneous nodules. One month later, she developed dyspnoea. Thoracic CT scan showed pleural thickening associated with pleural effusion. Pleural biopsy confirmed the diagnosis of pleural plasmacytoma. Chemotherapy including vincristine, doxorubicin and dexamethasone was administered. Cutaneous involvement and pleural effusion accompanying MM are uncommon. They are associated with poor prognosis.
authors.affiliation: Charles Nicolle Hospital, Tunis, Tunisia.
authors.forename: Olfa
authors.initials: O
authors.lastname: Saidane
authors.affiliation: Department of Rheumatology, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Maroua
authors.initials: M
authors.lastname: Slouma
authors.affiliation: Tunis El Manar University, Tunis, Tunisia.
authors.forename: Slim
authors.initials: S
authors.lastname: Haouet
authors.affiliation: Tunis El Manar University, Tunis, Tunisia.
authors.forename: Leila
authors.initials: L
authors.lastname: Abdelmoula
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D020405:Dermis / Q000473:pathology*; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000473:pathology*; D010954:Plasmacytoma / Q000188:drug therapy / Q000556:secondary*; D010994:Pleura / Q000473:pathology*; D010996:Pleural Effusion / Q000209:etiology; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000556:secondary*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary*; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin