title: Dramatic Improvement of Diabetes Mellitus Following the Treatment of Coexisting Acromegaly and Cushing's Syndrome.
abstract: Endocrine diseases are frequently accompanied by diabetes mellitus and treatment of an underlying endocrine disease often improves glucose control. The co-occurrence of acromegaly and Cushing's syndrome is extremely rare. We herein describe a patient who showed a dramatic improvement in glucose control following treatment for co-existing acromegaly and Cushing's syndrome. An adrenal mass was incidentally discovered during a routine evaluation of a 56-year-old woman who was subsequently diagnosed with acromegaly and a unilateral cortisol-producing adrenal adenoma. Her blood glucose was poorly controlled despite receiving high-dose insulin therapy. After undergoing adrenalectomy for Cushing's syndrome, her insulin dosage was decreased by almost 50%. The insulin treatment was discontinued following the treatment of acromegaly.
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, South Korea.
authors.forename: Soo Kyoung
authors.initials: SK
authors.lastname: Kim
authors.forename: Bo Ra
authors.initials: BR
authors.lastname: Kim
authors.forename: Kyongyoung
authors.initials: K
authors.lastname: Kim
authors.forename: Sungsu
authors.initials: S
authors.lastname: Kim
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Jung
authors.forename: Jong Ryeal
authors.initials: JR
authors.lastname: Hahm
authors.forename: Jaehoon
authors.initials: J
authors.lastname: Jung
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D000315:Adrenalectomy; D001786:Blood Glucose / Q000378:metabolism*; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D033162:Incidental Findings; D007328:Insulin / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006854:Hydrocortisone; D007004:Hypoglycemic Agents; D007328:Insulin; C517652:hemoglobin A1c protein, human