title: [Antimycoplasmic Activity of Fermentation Broth of Trichoderma harzianum Rifai F-180, an Organism Producing L-Lysine-α-Oxidase, an Antitumor and Antiviral Enzyme].
abstract: A concentrate of the fermentation broth of Trichoderma harzianum Rifai F-180, an organism producing L-lysine-α-oxidase, an antitumor and antiviral enzyme, with the activity in the fermentation broth of 0.54-0.56 U/mI was recovered. The effect of the concentrate on the mycoplasmas growth was investigated for the first time. Two representatives of Mycoplasmafaceae, i.e. Mycoplasma hominis and Mycoplasma fermentans and one representative of Aholeplasmataceae. i. e. Aholeplasma laidlawii were used. It was shown that the fermentation broth inhibited the growth of Mycoplasma hominis after the preliminary exposure. The inhibition rate depended on the mycoplasma inoculation dose and the fermentation broth concentration.
authors.forename: I P
authors.initials: IP
authors.lastname: Smirnova
authors.forename: I V
authors.initials: IV
authors.lastname: Rakovskaya
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000737:chemistry* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification; D003470:Culture Media / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005285:Fermentation; D016858:Mycoplasma fermentans / Q000187:drug effects / Q000254:growth & development; D019535:Mycoplasma hominis / Q000187:drug effects* / Q000254:growth & development; D014242:Trichoderma / Q000737:chemistry / Q000201:enzymology* / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D003470:Culture Media; D000594:Amino Acid Oxidoreductases; C041123:L-lysine oxidase