title: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A case report and review of literature.
abstract: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described inflammatory disease of central nervous system with distinct clinical and radiological features. The etiopathogenesis of this rare entity remains to be understood. The histopathological findings closely resemble chronic inflammatory diseases like sarcoidosis and malignancies like lymphoma. With advancements in serology, immunopathology and radiology CLIPPERS is identified as a distinct entity that differs considerably in its clinical presentation, immunopathology, radiological findings and response to steroids. We describe a case that presented to us with progressive quadriparesis and lower cranial nerve deficits whose radiological and pathological findings were consistent with CLIPPERS. The patient had a good outcome with long term immunosuppression.
authors.affiliation: Department of Neurosurgery, Apollo Health City, Jubilee Hills, Hyderabad, Andhra Pradesh, India.
authors.forename: Soma Madhan
authors.initials: SM
authors.lastname: Reddy
authors.affiliation: Department of Neurosurgery, Apollo Health City, Jubilee Hills, Hyderabad, Andhra Pradesh, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Lath
authors.affiliation: Department of Pathology, Apollo Health City, Jubilee Hills, Hyderabad, Andhra Pradesh, India.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Swain
authors.affiliation: Department of Neurosurgery, Apollo Health City, Jubilee Hills, Hyderabad, Andhra Pradesh, India.
authors.forename: Alok
authors.initials: A
authors.lastname: Ranjan
keywords: Brainstem mass; CLIPPERS; pontine lesion