title: Incidence, causes and phenotypes of acute seizures in Kenyan children post the malaria-decline period.
abstract: BACKGROUND
  Acute seizures are a common cause of paediatric admissions to hospitals in Africa, and malaria is an important cause of seizures in endemic areas. Malaria has declined in the past decade whilst neonatal admissions have increased, both which may affect the incidence and phenotypes of acute seizures in African children.
  
  
  METHODS
  We examined the effect of recent decline in malaria and the increasing burden of neonatal admissions on the incidence, causes and phenotypes of acute seizures admitted to hospital from 2009-2013. We used logistic regression to measure associations and Poisson regression to calculate the incidence and rate ratios.
  
  
  RESULTS
  The overall incidence of acute seizures over the 5-year period was 312 per 100,000/year (95% CI, 295-329): 116 per 100,000/year (95% CI, 106-127) for complex seizures and 443 per 100,000 live births (95% CI, 383-512) for neonatal seizures. Over the period, there was an increase in incidence of seizures-attributable to malaria (SAM) (incidence rate ratio (IRR) = 1.25; p < 0.001), but neither non-SAM (IRR = 1.03; p = 0.569) nor neonatal seizures (IRR = 0.99; p = 0.905). Important causes of acute seizures were malaria (33%) and respiratory tract infections (19%); and for neonatal seizures were neonatal sepsis (51%), hypoglycemia (41%) and hypoxic-ischemic encephalopathy (21%). Mortality occurred in 6% of all acute seizures, being more common in complex seizures (8%) and neonatal seizures (10 %) than other seizures (p < 0.001 for both comparisons).
  
  
  CONCLUSIONS
  Acute seizures remain common in children despite a decline in the incidence of malaria; suggesting that causes for these seizures need to be prevented in the community.
authors.affiliation: KEMRI-Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya. seremkipyego@hotmail.com.
authors.forename: George K
authors.initials: GK
authors.lastname: Serem
authors.affiliation: KEMRI-Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya. cnewton@kemri-wellcome.org.|Department of Psychiatry, University of Oxford, Oxford, UK. cnewton@kemri-wellcome.org.
authors.forename: Charles Rjc
authors.initials: CR
authors.lastname: Newton
authors.affiliation: KEMRI-Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya. skariuki@kemri-wellcome.org.|Nuffield Department of Medicine, University of Oxford, Oxford, UK. skariuki@kemri-wellcome.org.
authors.forename: Symon M
authors.initials: SM
authors.lastname: Kariuki
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000453:epidemiology; D020925:Hypoxia-Ischemia, Brain / Q000453:epidemiology; D015994:Incidence; D007223:Infant; D007630:Kenya / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology*; D008297:Male; D012141:Respiratory Tract Infections / Q000453:epidemiology; D012640:Seizures / Q000453:epidemiology* / Q000209:etiology*; D018805:Sepsis / Q000453:epidemiology