title: Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis.
abstract: IL-1β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and membrane-bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor-positive cells in an immunocompetent subset but also on the density of receptor expression. The objective of this study was to investigate the expression of IL-1β membrane-bound receptors (IL-1R1 and IL-1R2) in terms of the percentage of receptor-positive cells and the number of receptors per cell in different subsets of immune cells in RA patients before and after a course of basic (excluding anticytokine) therapy and in healthy individuals. The resulting data indicate differences in the expression of IL-1β receptors among T cells, B cells, and monocytes in healthy volunteers and in rheumatoid arthritis patients. The importance of determining both the relative percentage of cells expressing receptors to immunomodulatory cytokines and the number of membrane-bound receptors per cell is highlighted by evidence of unidirectional or multidirectional changing of these parameters according to cell subset and health status.
authors.affiliation: Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya Street 14, Novosibirsk 630099, Russia.
authors.forename: Alina A
authors.initials: AA
authors.lastname: Alshevskaya
authors.affiliation: Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya Street 14, Novosibirsk 630099, Russia.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Lopatnikova
authors.affiliation: Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya Street 14, Novosibirsk 630099, Russia.
authors.forename: Nadezhda S
authors.initials: NS
authors.lastname: Shkaruba
authors.affiliation: Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya Street 14, Novosibirsk 630099, Russia.
authors.forename: Oksana A
authors.initials: OA
authors.lastname: Chumasova
authors.affiliation: Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya Street 14, Novosibirsk 630099, Russia.
authors.forename: Aleksey E
authors.initials: AE
authors.lastname: Sizikov
authors.affiliation: I.M. Sechenov First Moscow State Medical University of the Ministry of Health, Bolshaya Pirogovskaya Street 2-4, Moscow 119991, Russia.
authors.forename: Aleksander V
authors.initials: AV
authors.lastname: Karaulov
authors.affiliation: Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya Street 14, Novosibirsk 630099, Russia.
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Kozlov
authors.affiliation: Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya Street 14, Novosibirsk 630099, Russia.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Sennikov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D001402:B-Lymphocytes / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism; D055815:Young Adult
chemical_list: D053583:Interleukin-1beta; D017472:Receptors, Interleukin-1