title: Dose-limiting toxicity and maximum tolerated dose: still fit for purpose?
authors.affiliation: Cancer Research UK Centre for Drug Development, Angel Building, London EC1V 4AD, UK; Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Box 193, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. Electronic address: han.wong@nhs.net.
authors.forename: Han Hsi
authors.initials: HH
authors.lastname: Wong
authors.affiliation: Cancer Research UK Centre for Drug Development, Angel Building, London EC1V 4AD, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Halford
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D017321:Clinical Trials, Phase I as Topic / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D006801:Humans; D020714:Maximum Tolerated Dose; D061214:Patient Safety; D012107:Research Design; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents