title: What is the Contribution of Genetics to Periodontal Risk?
abstract: This review addresses the multicausal etiology of periodontitis, in which genetic factors play a role. The various proposed causes for periodontitis always work simultaneously, but the relative contribution of each of these varies from case to case. We are still at an early stage to identify the genes involved, in comparison with other chronic diseases. To date, the genetic variations firmly and repeatedly associated with periodontitis in some populations are found within the following genes: ANRIL, COX2, IL1, IL10, DEFB1, whereas many other proposed periodontitis candidate genes have not been firmly proven or replicated.
authors.affiliation: Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, VU University Amsterdam, Gustav Mahlerlaan 3004, Amsterdam 1081 LA, The Netherlands. Electronic address: b.g.loos@acta.nl.
authors.forename: Bruno G
authors.initials: BG
authors.lastname: Loos
authors.affiliation: Department of Mathematics, Center for Research and Applications of Nonlinear Systems, University of Patras, Panepistimioupoli Patron 265 04, Patras, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Papantonopoulos
authors.affiliation: Department of Periodontology, Operative and Preventive Dentistry, Center of Dento-Maxillo-Facial Medicine, Faculty of Medicine, University of Bonn, Regina-Pacis-Weg 3, Bonn 53113, Germany.
authors.forename: Søren
authors.initials: S
authors.lastname: Jepsen
authors.affiliation: Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, VU University Amsterdam, Gustav Mahlerlaan 3004, Amsterdam 1081 LA, The Netherlands.
authors.forename: Marja L
authors.initials: ML
authors.lastname: Laine
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D010518:Periodontitis / Q000235:genetics*
keywords: Candidate gene; Complex disease; Etiology; GWAS; Genetics; Multi-causality; Periodontitis