title: Thermodynamic Analysis of Allosteric and Chelate Cooperativity in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes.
abstract: A detailed thermodynamic analysis of the axle-wheel binding in di- and trivalent secondary ammonium/[24]crown-8 pseudorotaxanes is presented. Isothermal titration calorimetry (ITC) data and double mutant cycle analyses reveal an interesting interplay of positive as well as negative allosteric and positive chelate cooperativity thus providing profound insight into the effects governing multivalent binding in these pseudorotaxanes.
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin , Takustraße 3, 14195 Berlin, Germany.
authors.forename: Karol
authors.initials: K
authors.lastname: Nowosinski
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin , Takustraße 3, 14195 Berlin, Germany.
authors.forename: Larissa K S
authors.initials: LK
authors.lastname: von Krbek
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin , Takustraße 3, 14195 Berlin, Germany.
authors.forename: Nora L
authors.initials: NL
authors.lastname: Traulsen
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin , Takustraße 3, 14195 Berlin, Germany.
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Schalley
mesh_terms: D043844:Crown Ethers / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D043844:Crown Ethers; D000644:Quaternary Ammonium Compounds; D043862:Rotaxanes