title: Therapeutic Potential of Date Palm Pollen for Testicular Dysfunction Induced by Thyroid Disorders in Male Rats.
abstract: Hyper- or hypothyroidism can impair testicular function leading to infertility. The present study was designed to examine the protective effect of date palm pollen (DPP) extract on thyroid disorder-induced testicular dysfunction. Rats were divided into six groups. Group I was normal control. Group II received oral DPP extract (150 mg kg(-1)), group III (hyperthyroid group) received intraperitoneal injection of L-thyroxine (L-T4, 300 μg kg(-1); i.p.), group IV received L-T4 plus DPP extract, group V (hypothyroid group) received propylthiouracil (PTU, 10 mg kg(-1); i.p.) and group VI received PTU plus DPP extract. All treatments were given every day for 56 days. L-T4 or PTU lowered genital sex organs weight, sperm count and motility, serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T), testicular function markers and activities of testicular 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase (17β-HSD). Moreover, L-T4 or PTU increased estradiol (E2) serum level, testicular oxidative stress, DNA damage and apoptotic markers. Morphometric and histopathologic studies backed these observations. Treatment with DPP extract prevented LT4- or PTU induced changes. In addition, supplementation of DPP extract to normal rats augmented sperm count and motility, serum levels of LH, T and E2 paralleled with increased activities of 3β-HSD and 17β-HSD as well as testicular antioxidant status. These results provide evidence that DPP extract may have potential protective effects on testicular dysfunction induced by altered thyroid hormones.
authors.affiliation: Hormone Evaluation Department, National Organization for Drug Control and Research, Giza, Egypt.
authors.forename: Akram M
authors.initials: AM
authors.lastname: El-Kashlan
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Nooh
authors.affiliation: Hormone Evaluation Department, National Organization for Drug Control and Research, Giza, Egypt.
authors.forename: Wafaa A
authors.initials: WA
authors.lastname: Hassan
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors.forename: Sherine M
authors.initials: SM
authors.lastname: Rizk
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D008297:Male; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D065749:Phoeniceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011058:Pollen / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013091:Spermatogenesis / Q000187:drug effects; D013733:Testicular Diseases / Q000188:drug therapy* / Q000209:etiology; D013959:Thyroid Diseases / Q000150:complications* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D010936:Plant Extracts