title: UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration.
abstract: Neurodegenerative diseases are a leading cause of disability and early death. A common feature of these conditions is disruption of protein homeostasis. Ubiquitin-like modifier activating enzyme 1 (UBA1), the E1 ubiquitin-activating enzyme, sits at the apex of the ubiquitin cascade and represents an important regulator of cellular protein homeostasis. Critical contributions of UBA1-dependent pathways to the regulation of homeostasis and degeneration in the nervous system are emerging, including specific disruption of UBA1 in spinal muscular atrophy (SMA) and Huntington's disease (HD). In this review we discuss recent findings that put UBA1 at the centre of cellular homeostasis and neurodegeneration, highlighting the potential for UBA1 to act as a promising therapeutic target for a range of neurodegenerative diseases.
authors.affiliation: Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
authors.forename: Ewout J N
authors.initials: EJN
authors.lastname: Groen
authors.affiliation: Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK. Electronic address: t.gillingwater@ed.ac.uk.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Gillingwater
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000628:therapy; D044764:Ubiquitin-Activating Enzymes / Q000502:physiology
chemical_list: C471538:UBA1 protein, human; D044764:Ubiquitin-Activating Enzymes