title: Investigation on Abnormal Iron Metabolism and Related Inflammation in Parkinson Disease Patients with Probable RBD.
abstract: OBJECTIVE
  To investigate potential mechanisms involving abnormal iron metabolism and related inflammation in Parkinson disease (PD) patients with probable rapid eye movement sleep behavior disorder (PRBD).
  
  
  METHODS
  Total 210 PD patients and 31 controls were consecutively recruited. PD patients were evaluated by RBD Screening Questionnaire (RBDSQ) and classified into PRBD and probable no RBD (NPRBD) groups. Demographics information were recorded and clinical symptoms were evaluated by series of rating scales. Levels of iron and related proteins and inflammatory factors in cerebrospinal fluid (CSF) and serum were detected. Comparisons among control, NPRBD and PRBD groups and correlation analyses between RBDSQ score and levels of above factors were performed.
  
  
  RESULTS
  (1) The frequency of PRBD in PD patients is 31.90%. (2) PRBD group has longer disease duration, more advanced disease stage, severer motor symptoms and more non-motor symptoms than NPRBD group. (3) In CSF, levels of iron, transferrin, NO and IL-1β in PRBD group are prominently increased. RBDSQ score is positively correlated with the levels of iron, transferrin, NO and IL-1β in PD group. Iron level is positively correlated with the levels of NO and IL-1β in PD group. (4) In serum, transferrin level is prominently decreased in PRBD group. PGE2 level in PRBD group is drastically enhanced. RBDSQ score exhibits a positive correlation with PGE2 level in PD group.
  
  
  CONCLUSIONS
  PRBD is common in PD patients. PRBD group has severer motor symptoms and more non-motor symptoms. Excessive iron in brain resulted from abnormal iron metabolism in central and peripheral systems is correlated with PRBD through neuroinflammation.
authors.affiliation: Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Shu-Yang
authors.initials: SY
authors.lastname: Yu
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zuo
authors.affiliation: Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Ying-Shan
authors.initials: YS
authors.lastname: Piao
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Chen-Jie
authors.initials: CJ
authors.lastname: Cao
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Ze-Jie
authors.initials: ZJ
authors.lastname: Chen
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Teng-Hong
authors.initials: TH
authors.lastname: Lian
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors.forename: Gai-Fen
authors.initials: GF
authors.lastname: Liu
authors.affiliation: Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Ya-Jie
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Department of Neurology and Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 10053, China.
authors.forename: Piu
authors.initials: P
authors.lastname: Chan
authors.affiliation: Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
authors.affiliation: Department of Physiology, Capital Medical University, Beijing, 100069, China.
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Wang
authors.affiliation: Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China; Beijing Key Laboratory on Parkinson Disease, Beijing, 100053, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000378:metabolism*; D020187:REM Sleep Behavior Disorder / Q000150:complications / Q000378:metabolism*
chemical_list: D007501:Iron