title: Hydrophilic Molecularly Imprinted Resorcinol-Formaldehyde-Melamine Resin Prepared in Water with Excellent Molecular Recognition in Aqueous Matrices.
abstract: Hydrophilic molecularly imprinted resorcinol-formaldehyde-melamine resin (MIRFM) is synthesized in water and shows excellent molecular recognition in aqueous matrices. The double functional monomers resorcinol and melamine, and the cross-linker formaldehyde, are all hydrophilic, and then the hydrophilic groups (such as hydroxyls, imino groups, and ether linkages) can be introduced into MIRFM, which make the material compatible with aqueous samples. The general principle is demonstrated by the synthesis of MIRFM using sulfanilamide as a dummy template for the selective recognition to sulfonamides (SAs) in milk samples. Resorcinol and melamine can interact with the template mainly by hydrogen bonding and π-π interaction, which makes MIRFM and the analytes have strong affinity. Besides, melamine can improve the rigidity of MIRFM and accelerate the polymerization process, so there is no need to add base or acid as a catalyst, which guarantees the success of molecular imprinting. MIRFM shows higher recovery and improved purification effect for SAs, in comparison to silica, HLB, C18, and SCX. Because of its excellent hydrophilicity and specificity, MIRFM is promising to be applied in biological, environmental, and clinical fields.
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University , Baoding, 071002, China.
authors.forename: Tianwei
authors.initials: T
authors.lastname: Lv
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University , Baoding, 071002, China.|Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University , Baoding, 071002, China.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Yan
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University , Baoding, 071002, China.
authors.forename: Jiankun
authors.initials: J
authors.lastname: Cao
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University , Baoding, 071002, China.
authors.forename: Shiru
authors.initials: S
authors.lastname: Liang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005557:Formaldehyde / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D054802:Molecular Imprinting; D012118:Resorcinols / Q000737:chemistry*; D052616:Solid Phase Extraction; D017550:Spectroscopy, Fourier Transform Infrared; D014227:Triazines / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D012118:Resorcinols; D014227:Triazines; D014867:Water; D005557:Formaldehyde; C011907:melamine; C031389:resorcinol