title: Serum γ-glutamyltranspeptidase and oxidative stress in subjectively healthy women: an association with menopausal stages.
abstract: BACKGROUND
  Gamma-glutamyltransferase (γ-GT) is used as a marker of alcohol-related pathology, while γ-GT is recently considered to be an oxidative stress marker.
  
  
  OBJECTIVE
  The present study aimed to investigate the correlation between the oxidative status and γ-GT levels, in association with menopausal stages.
  
  
  METHODS
  In total, 252 women, who were subjectively healthy, were divided into three groups: premenopausal, perimenopausal, and postmenopausal. The circulating oxidative status was evaluated by the diacron-reactive oxygen metabolite (d-ROM) test. In addition to serum γ-GT, routine blood investigations, including lipid, glucose, and inflammatory parameters, were performed.
  
  
  RESULTS
  The median γ-GT level was 17 U/L and the mean d-ROM level was 335 Carr U in all subjects. On multiple regression analysis, independent significant positive correlations were observed between d-ROM and high-sensitivity CRP levels in three groups, while there was a significant positive correlation between d-ROM and γ-GT levels only in the premenopausal group but not in the perimenopausal and postmenopausal groups.
  
  
  CONCLUSIONS
  The significant relationship between d-ROM and γ-GT at active estrogen stage may indicate a different oxidative stress condition by memopausal stage. The reasons of this relationship should be further explored.
  
  
  CONCLUSIONS
  A positive relationship between d-ROM and γ-GT levels, both as known as oxidative stress-related markers, could exist in premenopausal women.
authors.affiliation: JT. Chen Clinic, Akasaka-Kaikan B1F, 2-13-5 Akasaka, Minato-Ku, Tokyo, 107-0052, Japan. chin-cl@m.jcnnet.jp.
authors.forename: Jui-Tung
authors.initials: JT
authors.lastname: Chen
authors.affiliation: Division of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D008055:Lipids; D005723:gamma-Glutamyltransferase
keywords: Alanine aminotransferase; Antioxidant; C-Reactive protein; Reactive oxygen species; γ-GT