title: Successful recanalization post endovascular therapy is associated with a decreased risk of intracranial haemorrhage: a retrospective study.
abstract: BACKGROUND
  The risks of intracranial haemorrhage (ICH) post intra-arterial therapy (IAT) for stroke are not well understood. We aimed to study the influence of recanalization status post IAT for anterior circulation stroke and posterior circulation stroke on ICH development.
  
  
  METHODS
  Retrospective analysis of 193 patients in a prospectively collected database of IAT stroke patients was performed. Successful recanalization was defined as a Thrombolysis in Cerebral Infarction Score of 2b or 3 and symptomatic ICH (SICH) as parenchymal hematoma type 2 (PH2) with neurological deterioration. The association between the recanalization status and ICH/SICH was investigated using logistic regression models adjusted for baseline characteristics selected by univariate analyses.
  
  
  RESULTS
  One hundred and thirty-six patients had successful recanalization post procedure, 41 patients developed ICH and 10 patients SICH. There was a statistically significant baseline imbalance between the groups with and without successful recanalization on gender, baseline National Institute of Health Stroke Scale (NIHSS) score, the use of intravenous tPA and intra-arterial urokinase (p < 0.05). Logistic regression analysis adjusted for the above variables and the time to digital subtraction angiography demonstrated a statistically significant association between successful recanalization and ICH (odds ratio 0.42; 95% CI 0.19, 0.95; p = 0.04).
  
  
  CONCLUSIONS
  Successful recanalization post endovascular therapy is statistically significantly and negatively associated with ICH.
authors.affiliation: Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia. david.wang@mh.org.au.
authors.forename: David T
authors.initials: DT
authors.lastname: Wang
authors.affiliation: Florey Institute of Neuroscience and Mental Health, Melbourne, Australia. leonidc@unimelb.edu.au.|RMIT University, Melbourne, Australia. leonidc@unimelb.edu.au.
authors.forename: Leonid
authors.initials: L
authors.lastname: Churilov
authors.affiliation: Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia. Richard.Dowling@mh.org.au.
authors.forename: Richard
authors.initials: R
authors.lastname: Dowling
authors.affiliation: Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia. peter.mitchell@mh.org.au.
authors.forename: Peter
authors.initials: P
authors.lastname: Mitchell
authors.affiliation: Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, 300 Grattan St, Parkville, Victoria, 3050, Australia. bernard.yan@mh.org.au.
authors.forename: Bernard
authors.initials: B
authors.lastname: Yan
mesh_terms: D000368:Aged; D001315:Australia / Q000453:epidemiology; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020521:Stroke / Q000628:therapy*; D015912:Thrombolytic Therapy