title: Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering.
abstract: Proper blood vessel networks are necessary for constructing and re-constructing tissues, promoting wound healing, and delivering metabolic necessities throughout the body. Conversely, an understanding of vascular dysfunction has provided insight into the pathogenesis and progression of diseases both common and rare. Recent advances in stem cell-based regenerative medicine - including advances in stem cell technologies and related progress in bioscaffold design and complex tissue engineering - have allowed rapid advances in the field of vascular biology, leading in turn to more advanced modeling of vascular pathophysiology and improved engineering of vascularized tissue constructs. In this review we examine recent advances in the field of stem cell-derived vasculature, providing an overview of stem cell technologies as a source for vascular cell types and then focusing on their use in three primary areas: studies of vascular development and angiogenesis, improved disease modeling, and the engineering of vascularized constructs for tissue-level modeling and cell-based therapies.
authors.affiliation: Medical Scientist Training Program, School of Medicine, Johns Hopkins University, Baltimore, MD, United States; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.
authors.forename: Justin
authors.initials: J
authors.lastname: Lowenthal
authors.affiliation: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, United States; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, United States; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, United States. Electronic address: gerecht@jhu.edu.
authors.forename: Sharon
authors.initials: S
authors.lastname: Gerecht
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001808:Blood Vessels / Q000166:cytology*; D064987:Cell- and Tissue-Based Therapy; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000166:cytology; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D008833:Microcirculation; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials
keywords: Blood vessels; Embryonic stem cell; Endothelial cells; Induced pluripotent stem cell; Pluripotent stem cell; Smooth muscle; Stem cell; Stem cell therapy; Tissue engineered blood vessels; Tissue engineered vasculature; Vascular; Vascular biology; Vasculature