title: The Mosaic of Rottlerin.
abstract: The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C δ (PKCδ) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl3 as a catalyst.
authors.affiliation: School of Chemistry, The University of New South Wales , Sydney, New South Wales 2052, Australia.
authors.forename: Kenneth K C
authors.initials: KK
authors.lastname: Hong
authors.affiliation: School of Chemistry, The University of New South Wales , Sydney, New South Wales 2052, Australia.
authors.forename: Graham E
authors.initials: GE
authors.lastname: Ball
authors.affiliation: School of Chemistry, The University of New South Wales , Sydney, New South Wales 2052, Australia.
authors.forename: David StC
authors.initials: DS
authors.lastname: Black
authors.affiliation: School of Chemistry, The University of New South Wales , Sydney, New South Wales 2052, Australia.
authors.forename: Naresh
authors.initials: N
authors.lastname: Kumar
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry; D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D010766:Phosphorylation; D051745:Protein Kinase C-delta / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000098:Acetophenones; D020533:Angiogenesis Inhibitors; D001578:Benzopyrans; D047188:Chalcones; C000606269:kamalachalcone A; C085746:rottlerin; D051745:Protein Kinase C-delta