title: Associations of polymorphisms in NAT2 gene with risk and metastasis of osteosarcoma in young Chinese population.
abstract: Osteosarcoma is the most common primary malignancy of bone in young individuals. Genetic factors may play an important role in the tumorigenesis of osteosarcoma. Here we carried out a case-control study to investigate seven NAT2 single-nucleotide polymorphisms (rs1799929, rs120, rs1041983, rs1801280, rs1799930, rs1799931, and rs1801279) on the risk and prognosis of osteosarcoma. This study included 260 young osteosarcoma cases and 286 controls. The TaqMan method was used to determine genotypes. We found that rs1799931 G>A polymorphisms were associated with a decreased risk of osteosarcoma in young Chinese population, and rs1041983 CT genotype seemed to play a protective role in the risk of osteosarcoma. However, further analysis showed that rs1041983 polymorphisms were associated with an elevated risk of tumor metastasis, predicting poor prognosis. This study provided the first evidence for the associations between NAT2 polymorphisms and osteosarcoma risk and metastasis in Chinese population.
authors.affiliation: Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Zhengxiang
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China ; Department of Orthopedics, The First People's Hospital of Wenling, Wenling, People's Republic of China.
authors.forename: Zhenghui
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Dongliang
authors.initials: D
authors.lastname: Wang
keywords: NAT2; SNP; metastasis; osteosarcoma; susceptibility