title: Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain.
abstract: Several arenavirus pathogens, such as Lassa and Junin viruses, inhibit macrophage activation, the molecular mechanism of which is unclear. We show that lymphocytic choriomeningitis virus (LCMV) can also inhibit macrophage activation, in contrast to Pichinde and Tacaribe viruses, which are not known to naturally cause human diseases. Using a recombinant Pichinde virus system, we show that the LCMV Z N-terminal domain (NTD) mediates the inhibition of macrophage activation and immune functions.
authors.affiliation: Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA.
authors.forename: Junji
authors.initials: J
authors.lastname: Xing
authors.affiliation: Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chai
authors.affiliation: Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA.
authors.forename: Hinh
authors.initials: H
authors.lastname: Ly
authors.affiliation: Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA liangy@umn.edu.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Liang
mesh_terms: D000818:Animals; D001117:Arenaviridae Infections / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000821:virology; D051379:Mice; D018052:Pichinde virus / Q000276:immunology*; D017434:Protein Structure, Tertiary
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C117526:p11 Z protein, Lymphocytic choriomeningitis virus