title: Targeting Polycomb systems to regulate gene expression: modifications to a complex story.
abstract: Polycomb group proteins are transcriptional repressors that are essential for normal gene regulation during development. Recent studies suggest that Polycomb repressive complexes (PRCs) recognize and are recruited to their genomic target sites through a range of different mechanisms, which involve transcription factors, CpG island elements and non-coding RNAs. Together with the realization that the interplay between PRC1 and PRC2 is more intricate than was previously appreciated, this has increased our understanding of the vertebrate Polycomb system at the molecular level.
authors.affiliation: Department of Biochemistry, South Parks Road, University of Oxford, OX1 3QU.
authors.forename: Neil P
authors.initials: NP
authors.lastname: Blackledge
authors.affiliation: Department of Biochemistry, South Parks Road, University of Oxford, OX1 3QU.
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Rose
authors.affiliation: Department of Biochemistry, South Parks Road, University of Oxford, OX1 3QU.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Klose
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D002843:Chromatin / Q000235:genetics; D018899:CpG Islands / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics*; D006657:Histones / Q000378:metabolism; D006801:Humans; D051379:Mice; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism*; D063151:Polycomb Repressive Complex 2 / Q000378:metabolism*; D022661:RNA, Untranslated / Q000235:genetics; D016601:RNA-Binding Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D018797:Cell Cycle Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones; C116662:PRC1 protein, human; D022661:RNA, Untranslated; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D063151:Polycomb Repressive Complex 2; D063150:Polycomb Repressive Complex 1