title: A Sickle Cell Disease Patient with Severe Tricuspid Regurgitation and Early Developed Pulmonary Hypertension.
abstract: Pulmonary hypertension (PH) worsens the mortality of the patients with sickle cell disease (SCD). The exact mechanism of PH development/progression in SCD, including the role of tricuspid regurgitation (TR), remains unclear. We herein report an unusual SCD case, complicated by chronic thromboembolic disorder, who developed severe TR and an accelerated progression of PH. Tricuspid valve surgery significantly ameliorated the patient's symptoms and reduced hospital readmission. The early detection and management of the reversible disorder accelerating the PH development in SCD patients may alter the clinical course, improve the quality of life, and potentially affect the long-term outcome.
authors.affiliation: Department of Medicine, SUNY Upstate Medical University, USA.
authors.forename: Gaurang
authors.initials: G
authors.lastname: Vaidya
authors.forename: Muhammad
authors.initials: M
authors.lastname: Sarwar
authors.forename: Zongxia
authors.initials: Z
authors.lastname: Sun
authors.forename: Tiemin
authors.initials: T
authors.lastname: Wei
authors.forename: Kan
authors.initials: K
authors.lastname: Liu
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D018450:Disease Progression; D004452:Echocardiography; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D011379:Prognosis; D011788:Quality of Life; D016896:Treatment Outcome; D014262:Tricuspid Valve Insufficiency / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery