title: Alcohol and Other Addictive Disorders Following Bariatric Surgery: Prevalence, Risk Factors and Possible Etiologies.
abstract: Bariatric surgery is currently the most effective intervention for significant and sustained weight loss in obese individuals. While patients often realize numerous improvements in obesity-related comorbidities and health-related quality of life, a small minority of patients have less optimal outcomes following bariatric surgery. The literature on the emergence of alcohol use disorders (AUDs) following bariatric surgery has grown in the past several years and collectively provides convincing evidence that a significant minority of patients develop new-onset AUDs following bariatric surgery. Rouxen-Y gastric bypass (RYGB) has generally been associated with the risk of developing an AUD, while laparoscopic adjustable gastric banding generally has not, in several large studies. One theory that has been discussed at some length is the idea of 'addiction transfer' wherein patients substitute one 'addiction' (food) for a new 'addiction' (alcohol) following surgery. Animal work suggests a neurobiological basis for increased alcohol reward following RYGB. In addition, several pharmacokinetic studies have shown rapid and dramatically increased peak alcohol concentrations following RYGB. The prevalence of alcohol and other addictive disorders and potential etiological contributors to post-operative AUDs will be explored.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND, USA.|Neuropsychiatric Research Institute, Fargo, ND, USA.
authors.forename: Kristine J
authors.initials: KJ
authors.lastname: Steffen
authors.affiliation: Neuropsychiatric Research Institute, Fargo, ND, USA.
authors.forename: Scott G
authors.initials: SG
authors.lastname: Engel
authors.affiliation: Department of Psychology, George Mason University, Fairfax, VA, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Wonderlich
authors.affiliation: University of Arkansas, Fayettville, AR, USA.
authors.forename: Garrett A
authors.initials: GA
authors.lastname: Pollert
authors.affiliation: Department of Neuroscience, University of North Dakota, ND, USA.
authors.forename: Cindy
authors.initials: C
authors.lastname: Sondag
mesh_terms: D019973:Alcohol-Related Disorders / Q000453:epidemiology* / Q000209:etiology; D050110:Bariatric Surgery / Q000009:adverse effects*; D016739:Behavior, Addictive / Q000453:epidemiology* / Q000209:etiology; D015390:Gastric Bypass / Q000009:adverse effects; D006801:Humans; D009765:Obesity / Q000523:psychology / Q000601:surgery*; D015995:Prevalence; D012307:Risk Factors
keywords: alcohol; bariatric surgery