title: Pressure Myography to Study the Function and Structure of Isolated Small Arteries.
abstract: Small arteries play an important role in regulation of peripheral resistance and organ perfusion. Here we describe a series of methods allowing measurements in pressurized segments of small arteries from the systemic and coronary circulation of mice as well as other species. The pressure myography techniques described include measurements of wall structure, wall stress, strain, and myogenic tone. The pressurized perfused small arteries also allow evaluation of responses to increases in pressure, flow, and drugs, where the main readout is changes in vascular diameter.
authors.affiliation: Department of Biomedicine, Aarhus University, DK-8000, Aarhus C, Denmark. olav_schjoerring@hotmail.com.|Department of Pulmonary and Cardiovascular Pharmacology, Aarhus University, DK-8000, Aarhus C, Denmark. olav_schjoerring@hotmail.com.|Department of Anesthesiology, Aalborg University Hospital, Aalborg, Denmark. olav_schjoerring@hotmail.com.
authors.forename: Olav L
authors.initials: OL
authors.lastname: Schjørring
authors.affiliation: Department of Biomedicine, Aarhus University, DK-8000, Aarhus C, Denmark.|Department of Pulmonary and Cardiovascular Pharmacology, Aarhus University, DK-8000, Aarhus C, Denmark.
authors.forename: Rune
authors.initials: R
authors.lastname: Carlsson
authors.affiliation: Department of Biomedicine, Aarhus University, DK-8000, Aarhus C, Denmark. us@biomed.au.dk.|Department of Pulmonary and Cardiovascular Pharmacology, Aarhus University, DK-8000, Aarhus C, Denmark. us@biomed.au.dk.
authors.forename: Ulf
authors.initials: U
authors.lastname: Simonsen
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology*; D001696:Biomechanical Phenomena; D003331:Coronary Vessels / Q000502:physiology; D004210:Dissection; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D051379:Mice; D008833:Microcirculation; D008955:Models, Cardiovascular; D009213:Myography / Q000379:methods*; D011312:Pressure; D012039:Regional Blood Flow; D012815:Signal Processing, Computer-Assisted; D059289:Vascular Stiffness; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents
keywords: Endothelium; Flow; Mice; Microvasculature; Myogenic tone; Pharmacology; Pressure; Small arteries; Stiffness; Structure