title: Surgical excision of ovarian endometriomas: Does it truly impair ovarian reserve? Long term anti-Müllerian hormone (AMH) changes after surgery.
abstract: OBJECTIVE
  The long-term effects of laparoscopic cystectomy on ovarian reserve in patients with unilateral and bilateral ovarian endometriomas were evaluated.
  
  
  METHODS
  A total of 22 patients undergoing laparoscopic cystectomy for unilateral endometrioma (n = 10) and bilateral endometriomas (n = 12) were included in the study.
  
  
  RESULTS
  Serum anti-Müllerian hormone (AMH) levels significantly decreased from the baseline value (3.98 ± 3.27 ng/mL) one (1.67 ± 1.56 ng/mL), three (2.01 ± 1.70 ng/mL), and six months (2.43 ± 2.39 ng/mL) postoperatively. There was no difference between preoperative and 12 month postoperative AMH levels (4.01 ± 3.39 ng/mL) (P > 0.05). Patients with bilateral endometriomas had a significantly higher rate of decline in AMH levels 12 months after surgery than patients with monolateral endometriomas (P = 0.035), but in both groups there was no difference in AMH levels at one and 12 months postoperatively (P > 0.05).
  
  
  CONCLUSIONS
  AMH levels temporarily decreased after laparoscopic cystectomy for ovarian endometriomas, with complete recovery of preoperative AMH values at 12 months postoperatively. This pattern was equal in patients with bilateral and unilateral ovarian involvement. Patients with bilateral cysts have higher rates of decline of AMH levels compared to patients with unilateral affection.
authors.affiliation: Department of Biomedical Science for the Health, University of Milan, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Vignali
authors.affiliation: Gynecologic Oncology and Minimally Invasive Pelvic Surgery Unit, Sacred Heart Hospital, Verona, Italy.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mabrouk
authors.affiliation: Department of Biomedical Science for the Health, University of Milan, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Ciocca
authors.affiliation: Department of Biomedical Science for the Health, University of Milan, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Alabiso
authors.affiliation: Department of Biomedical Science for the Health, University of Milan, Italy.
authors.forename: Allegra
authors.initials: A
authors.lastname: Barbasetti di Prun
authors.affiliation: Molecular Biology Laboratory, Istituto Auxologico Italiano, Milan, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Gentilini
authors.affiliation: Department of Biomedical Science for the Health, University of Milan, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Busacca
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D004715:Endometriosis / Q000097:blood / Q000601:surgery*; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D010049:Ovarian Diseases / Q000097:blood / Q000601:surgery*; D065851:Ovarian Reserve / Q000502:physiology*
chemical_list: D054304:Anti-Mullerian Hormone
keywords: AMH; endometriosis; laparoscopy; ovarian reserve