title: Candida lusitaniae MICs to the echinocandins are elevated but FKS-mediated resistance is rare.
abstract: MIC values were generated for caspofungin, micafungin, and anidulafungin against 106 isolates of C. lusitaniae, and these values were compared to established epidemiologic cutoff values. The majority of isolates were wild type both by MIC value as well as by FKS1 hotspot sequencing. Although C. lusitaniae isolates have MIC values to the echinocandins that are elevated compared to other common species, with regard to known mechanisms of resistance to the echinocandins, isolates with MIC values at or below the epidemiological cutoff values of 0.5 and 1 μg/mL for micafungin and anidulafungin, respectively, should be considered wild type.
authors.affiliation: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: gyi2@cdc.gov.
authors.forename: Shawn R
authors.initials: SR
authors.lastname: Lockhart
authors.affiliation: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Cau D
authors.initials: CD
authors.lastname: Pham
authors.affiliation: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Kuykendall
authors.affiliation: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Carol B
authors.initials: CB
authors.lastname: Bolden
authors.affiliation: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Angela A
authors.initials: AA
authors.lastname: Cleveland
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005964:Glucosyltransferases / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D017422:Sequence Analysis, DNA
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D005964:Glucosyltransferases
keywords: Candida lusitaniae; Echinocandin; Epidemiological cutoff value; FKS