title: Cationic Cobalt(III)-Catalyzed Aryl and Alkenyl C-H Amidation: A Mild Protocol for the Modification of Purine Derivatives.
abstract: A cationic cobalt(III)-catalyzed direct C-H amidation of unactivated (hetero)arenes and alkenes by using 1,4,2-dioxazol-5-ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant-free conditions with a broad substrate scope. Moreover, 6-arylpurine compounds, which often exhibit high potency in antimycobacterial, cytostatic, and anti-HCV activities, can be smoothly amidated, thus offering a mild protocol for their late stage functionalization.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (P. R. China), Fax: (+86) 10-82805297 http://sklnbd.bjmu.edu.cn/nj/
authors.forename: Yujie
authors.initials: Y
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (P. R. China), Fax: (+86) 10-82805297 http://sklnbd.bjmu.edu.cn/nj/
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (P. R. China), Fax: (+86) 10-82805297 http://sklnbd.bjmu.edu.cn/nj/
authors.forename: Conghui
authors.initials: C
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (P. R. China), Fax: (+86) 10-82805297 http://sklnbd.bjmu.edu.cn/nj/
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (P. R. China), Fax: (+86) 10-82805297 http://sklnbd.bjmu.edu.cn/nj/. jiaoning@bjmu.edu.cn.|State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032 (P. R. China). jiaoning@bjmu.edu.cn.
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
keywords: CH functionalization; CN bond formation; amidation; cobalt; purine compounds