title: Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis.
abstract: OBJECTIVE
  Several studies have evaluated the association between CYP1A1 polymorphisms and the susceptibility of chronic obstructive pulmonary disease (COPD) with inconclusive results. We performed the first comprehensive meta-analysis to summarize the association between CYP1A1 polymorphisms and COPD risk.
  
  
  METHODS
  A systematic literature search was conducted (up to April 2015) in five online databases: PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), WeiPu, and WanFang databases. The strength of association was calculated by odds ratio (OR) and corresponding 95% confidence interval (CI).
  
  
  RESULTS
  Seven case-control studies with 1050 cases and 1202 controls were included. Our study suggested a significant association between the MspI polymorphism and COPD risk (CC versus TC + TT: OR = 1.57, CI: 1.09-2.26, P = 0.02; CC versus TT: OR = 1.73, CI: 1.18-2.55, P = 0.005). For the Ile/Val polymorphism, a significant association with COPD risk was observed (GG versus AG + AA: OR = 2.75, CI: 1.29-5.84, P = 0.009; GG versus AA: OR = 3.23, CI: 1.50-6.93, P = 0.003; AG versus AA: OR = 1.39, CI: 1.01-1.90, P = 0.04). Subgroup analysis indicated a significant association between the MspI variation and COPD risk among Asians (CC versus TC + TT: OR = 1.70, CI: 1.06-2.71, P = 0.03; CC versus TT: OR = 1.84, CI: 1.11-3.06, P = 0.02).
  
  
  CONCLUSIONS
  The MspI and Ile/Val polymorphisms might alter the susceptibility of COPD, and MspI polymorphism might play a role in COPD risk among Asian population.
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Cheng-Di
authors.initials: CD
authors.lastname: Wang
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Chen
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Huang
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Wang
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Chen
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Ya-Mei
authors.initials: YM
authors.lastname: Jiang
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Ya-Zhou
authors.initials: YZ
authors.lastname: He
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Ji
mesh_terms: D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017594:Publication Bias; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology* / Q000235:genetics*
chemical_list: C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1