title: Expression of Heat Shock Protein 27 in Benign Prostatic Hyperplasia with Chronic Inflammation.
abstract: BACKGROUND
  Heat shock protein 27 (HSP 27) is known as a mediator in immune response and has been recently found to be expressed in prostate cancer. This study aimed to investigate the role of HSP27 in inflammatory BPH.
  
  
  METHODS
  Hospitalized BPH patients who received TURP were divided into 4 groups by the presence and degrees of chronic inflammation: non-inflammatory BPH (NI BPH), mild-inflammatory BPH (MI BPH), moderate-inflammatory BPH (MOI BPH), and severe-inflammatory BPH (SI BPH). Expressions of HSP 27, TNF-α, IL-6, and CD3 in prostate tissues and serum of patients were detected by immunohistochemistry and ELISA.
  
  
  RESULTS
  Expression of HSP27 in BPH with histological inflammation was significantly higher than in non-inflammatory BPH. In inflammatory BPH groups, HSP27 expression gradually increased along with increasing inflammation. There was a significant correlation between the expression of TNF-α, IL-6, CD3 and HSP27 among different inflammatory BPH groups.
  
  
  CONCLUSIONS
  HSP27 expression level is associated with the degree of chronic inflammation in BPH and may participate in the pathological process in inflammatory BPH.
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Anesthesiology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
authors.forename: Xiuli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
authors.forename: Yuexian
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
authors.forename: Wenping
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Urology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
authors.forename: Shijie
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
authors.forename: Wenqing
authors.initials: W
authors.lastname: Cai
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D017252:CD3 Complex / Q000097:blood; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D018120:Finasteride / Q000627:therapeutic use; D005786:Gene Expression Regulation; D055551:HSP27 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism*; D006360:Heat-Shock Proteins; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood; D059411:Lower Urinary Tract Symptoms / Q000628:therapy; D008297:Male; D018832:Molecular Chaperones; D011467:Prostate / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism; D020728:Transurethral Resection of Prostate; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000317:Adrenergic alpha-Antagonists; D014408:Biomarkers, Tumor; D017252:CD3 Complex; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; C508600:IL6 protein, human; D015850:Interleukin-6; D018832:Molecular Chaperones; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D018120:Finasteride