title: New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y2) isolated from the South China Sea.
abstract: Three new depsidones, botryorhodines E-G (1-3), and two new isoindolinones, meyeroguillines A and B (7 and 9), along with five known compounds were isolated from an endophytic fungus Meyerozyma guilliermondii, derived from the mangrove plant Kandelia obovata. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry (HREIMS). Compounds 1-6 exhibited strong α-glucosidase inhibitory activity with IC50 values ranging from 2.1 to 13.3 μM. Moreover, kinetic studies of compounds 2 and 6 showed that both of them were noncompetitive inhibitors of α-glucosidase.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xin gang West Road, Guangzhou 510275, China ; Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou 510080, China.
authors.forename: Senhua
authors.initials: S
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xin gang West Road, Guangzhou 510275, China ; Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou 510080, China.
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xin gang West Road, Guangzhou 510275, China ; Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou 510080, China.
authors.forename: Yayue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou 510080, China ; School of Life Sciences and Biomedical Center, Sun Yat-Sen University, 135 Xin gang West Road, Guangzhou 510275, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou 510080, China.
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xin gang West Road, Guangzhou 510275, China ; Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou 510080, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
keywords: Meyerozyma guilliermondii; depsidone; endophytic fungus; isoindolinone; α-glucosidase inhibitory activity