title: Nuclear Reformation at the End of Mitosis.
abstract: Cells have developed highly sophisticated ways to accurately pass on their genetic information to the daughter cells. In animal cells, which undergo open mitosis, the nuclear envelope breaks down at the beginning of mitosis and the chromatin massively condenses to be captured and segregated by the mitotic spindle. These events have to be reverted in order to allow the reformation of a nucleus competent for DNA transcription and replication, as well as all other nuclear processes occurring in interphase. Here, we summarize our current knowledge of how, in animal cells, the highly compacted mitotic chromosomes are decondensed at the end of mitosis and how a nuclear envelope, including functional nuclear pore complexes, reassembles around these decondensing chromosomes.
authors.affiliation: Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, 72076 Tübingen, Germany.
authors.forename: Anna Katharina
authors.initials: AK
authors.lastname: Schellhaus
authors.affiliation: Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, 72076 Tübingen, Germany.
authors.forename: Paola
authors.initials: P
authors.lastname: De Magistris
authors.affiliation: Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, 72076 Tübingen, Germany. Electronic address: wolfram.antonin@tuebingen.mpg.de.
authors.forename: Wolfram
authors.initials: W
authors.lastname: Antonin
mesh_terms: D000818:Animals; D002843:Chromatin / Q000502:physiology; D002875:Chromosomes / Q000502:physiology; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D022022:Nuclear Pore / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology
chemical_list: D002843:Chromatin
keywords: chromatin decondensation; mitotic exit; nuclear envelope; nuclear pore complex