title: Organocatalytic multicomponent synthesis of polysubstituted pyrroles from 1,2-diones, aldehydes and arylamines.
abstract: We have developed an organocatalyzed three-component reaction of 1,2-diones, aldehydes and arylamines, which provides an efficient approach to access polysubstituted pyrroles. In the catalysis of 4-methylbenzenesulfonic acid monohydrate, the reactions of a wide range of 1,2-diones, arylamines and aldehydes took place smoothly to generate the corresponding polysubstituted pyrroles in acceptable to good yields under mild reaction conditions.
authors.affiliation: Institute and State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering Nankai University, Tianjin 300071, P. R. China. z.h.zhou@nankai.edu.cn.
authors.forename: Yin
authors.initials: Y
authors.lastname: Zheng
authors.forename: Youming
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001557:Benzenesulfonates / Q000737:chemistry; D019817:Benzoic Acid / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D014269:Trifluoroacetic Acid / Q000737:chemistry
chemical_list: C573194:4-methylbenzenesulfonic acid; D000447:Aldehydes; D000588:Amines; D001557:Benzenesulfonates; D007659:Ketones; D008698:Mesylates; D011758:Pyrroles; C045880:methanesulfonic acid; D019817:Benzoic Acid; D014269:Trifluoroacetic Acid; D019342:Acetic Acid