title: GIRK Channel Plasticity and Implications for Drug Addiction.
abstract: Drugs of abuse can "hijack" synaptic plasticity, a physiological basis of learning and memory, establishing maladaptations that can promote drug addiction. A wealth of data supports the existence and importance of neuroadaptations in excitatory neurotransmission upon drug exposure. Recent discoveries, however, have shown that inhibitory neurotransmission mediated by G protein-gated inwardly rectifying potassium (K(+)) (GIRK/Kir3) channels is also subject to adaptation triggered by exposure to drugs of abuse. GIRK channels are expressed in neuronal populations relevant to reward and reward-related behaviors, where their activation by neurotransmitters such as GABA, dopamine, and adenosine reduces neuronal excitability. Studies in animal models have implicated GIRK channels in a number of behaviors including reward. Drugs of abuse also affect the inhibitory neurotransmission mediated by GIRK channels. These changes might be important for the development, maintenance, or relapse of addiction, making GIRK channels promising targets for novel addiction therapies.
authors.affiliation: Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Marron Fernandez de Velasco
authors.affiliation: Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Nora
authors.initials: N
authors.lastname: McCall
authors.affiliation: Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: wickm002@umn.edu.
authors.forename: Kevin
authors.initials: K
authors.lastname: Wickman
mesh_terms: D000818:Animals; D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels / Q000378:metabolism*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D012201:Reward; D019966:Substance-Related Disorders / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels
keywords: Dopamine; GABA(B) receptors; Mesocorticolimbic system; Neuroadaptations; Psychostimulants; RGS; SNX27; Trafficking