title: First-Trimester Placental Growth Factor in Screening for Gestational Diabetes.
abstract: OBJECTIVE
  The aim of this study was first to assess whether first-trimester serum concentrations of placental growth factor (PlGF) differ between patients with and without gestational diabetes (GDM) and second to test whether there is a correlation between glycosylated hemoglobin (HbA1c), a factor recently shown to be useful in predicting GDM, and PlGF.
  
  
  METHODS
  PlGF was measured at 8-14 weeks with the Kryptor Immunoassay Analyzer (Brahms, Berlin, Germany). Absolute values were converted to multiples of the median using the software provided by the Fetal Medicine Foundation London. GDM was diagnosed using internationally accepted criteria. HbA1c levels were quantified using the TOSOH G7 automated hemoglobin analyzer.
  
  
  RESULTS
  From January to December 2014, 328 women were included in the study, 51 (15.5%) of whom developed GDM. First-trimester PlGF quantification does not discriminate between women at risk to develop GDM and controls, while HbA1c is able to do so. No correlation was found between PlGF and HbA1c.
  
  
  CONCLUSIONS
  Our findings do not lend support to the hypothesis that early PlGF values are different in women who later develop GDM.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital and University of Bern, Bern, Switzerland.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Mosimann
authors.forename: Sophia
authors.initials: S
authors.lastname: Amylidi
authors.forename: Lorenz
authors.initials: L
authors.lastname: Risch
authors.forename: Ute
authors.initials: U
authors.lastname: Wiedemann
authors.forename: Daniel
authors.initials: D
authors.lastname: Surbek
authors.forename: Marc
authors.initials: M
authors.lastname: Baumann
authors.forename: Christoph
authors.initials: C
authors.lastname: Stettler
authors.forename: Luigi
authors.initials: L
authors.lastname: Raio
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016640:Diabetes, Gestational / Q000175:diagnosis*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; D000072483:Placenta Growth Factor; C517652:hemoglobin A1c protein, human