title: Measurement of Foveal Avascular Zone Dimensions and its Reliability in Healthy Eyes Using Optical Coherence Tomography Angiography.
abstract: OBJECTIVE
  To measure foveal avascular zone (FAZ) dimensions in healthy eyes using optical coherence tomography angiography (OCTA) and calculate interobserver variability.
  
  
  METHODS
  Reliability analysis.
  
  
  METHODS
  Thirty-four eyes of 17 healthy subjects underwent OCTA at the Retina Service of Wills Eye Hospital. Two masked graders performed measurements of FAZ dimensions including area, perimeter, and maximum horizontal and vertical diameters using ImageJ. Intraclass correlation coefficient (ICC) between graders was calculated.
  
  
  RESULTS
  Mean area (mm(2)), perimeter (mm), and maximum horizontal and vertical diameters (mm) were 0.27 ± 0.101, 2.21 ± 0.451, 0.59 ± 0.126, and 0.56 ± 0.118, respectively, at the superficial and 0.34 ± 0.116, 2.50 ± 0.462, 0.69 ± 0.123, and 0.63 ± 0.110 at the deep network. Interobserver agreement was high for all superficial FAZ measurements (ICC ≥0.90) but did not meet the lowest acceptable grader agreement for the deep vascular network (ICC <0.85). Fellow eyes had statistically similar values (P > .05).
  
  
  CONCLUSIONS
  Manual measurement of FAZ dimensions using OCTA is a noninvasive and reliable method for quantifying FAZ at the superficial vascular network. Assessing FAZ alterations in the deep vascular network may be subject to greater interobserver variability.
authors.affiliation: Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Abtin
authors.initials: A
authors.lastname: Shahlaee
authors.affiliation: Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Maria
authors.initials: M
authors.lastname: Pefkianaki
authors.affiliation: Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Jason
authors.initials: J
authors.lastname: Hsu
authors.affiliation: Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address: acho@att.net.
authors.forename: Allen C
authors.initials: AC
authors.lastname: Ho
mesh_terms: D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000098:blood supply / Q000166:cytology*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D012171:Retinal Vessels / Q000166:cytology*; D041623:Tomography, Optical Coherence