title: [Progress of molecular genetics research on rheumatoid arthritis].
abstract: Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disorder that principally attacks flexible joints and synovia. The precise pathogenesis of RA remains unclear, and genetic factors probably play an important role in its etiology. In addition to genes from human leukocyte antigen (HLA) region, such as HLA-DRB, genes from non-HLA region, such as TIM-3, PTPN22, TRAF1/C5, STAT4, CCR5, PADI4 and FCGR2A may also contribute to its susceptibility. The advance in molecular genetics research on RA is reviewed here.
authors.affiliation: Department of Microbiology and Immunology, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China. Email: zdd25@sina.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.forename: Jiaming
authors.initials: J
authors.lastname: Luo
authors.forename: Dingding
authors.initials: D
authors.lastname: Zhang
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D059472:Exome; D020022:Genetic Predisposition to Disease; D059811:HLA-DRB1 Chains / Q000235:genetics; D000072597:Hepatitis A Virus Cellular Receptor 2; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics; D017452:Receptors, IgG / Q000235:genetics
chemical_list: C445323:FCGR2A protein, human; C448908:HAVCR2 protein, human; D059811:HLA-DRB1 Chains; D000072597:Hepatitis A Virus Cellular Receptor 2; D008565:Membrane Proteins; D017452:Receptors, IgG; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22