title: Cell mechanics in biomedical cavitation.
abstract: Studies on the deformation behaviours of cellular entities, such as coated microbubbles and liposomes subject to a cavitation flow, become increasingly important for the advancement of ultrasonic imaging and drug delivery. Numerical simulations for bubble dynamics of ultrasound contrast agents based on the boundary integral method are presented in this work. The effects of the encapsulating shell are estimated by adapting Hoff's model used for thin-shell contrast agents. The viscosity effects are estimated by including the normal viscous stress in the boundary condition. In parallel, mechanical models of cell membranes and liposomes as well as state-of-the-art techniques for quantitative measurement of viscoelasticity for a single cell or coated microbubbles are reviewed. The future developments regarding modelling and measurement of the material properties of the cellular entities for cutting-edge biomedical applications are also discussed.
authors.affiliation: School of Mathematics , University of Birmingham , Birmingham B15 2TY , UK.
authors.forename: Qianxi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: School of Mathematics , University of Birmingham , Birmingham B15 2TY , UK ; Department of Mathematics, College of Science , Salahaddin University-Erbil , Kurdistan Region , Iraq.
authors.forename: Kawa
authors.initials: K
authors.lastname: Manmi
authors.affiliation: School of Engineering , University of Warwick , Coventry CV4 7AL , UK.
authors.forename: Kuo-Kang
authors.initials: KK
authors.lastname: Liu
keywords: boundary integral method; membrane mechanics; microbubble dynamics; single-cell mechanics; ultrasonic cavitation