title: Involvement of sinoaortic afferents in renal sympathoinhibition and vasodilation induced by acute hypernatremia.
abstract: Despite the abundance of evidence that supports the important role of aortic and carotid afferents to short-term regulation of blood pressure and detection of variation in the arterial PO2 , PCO2 and pH, relatively little is known regarding the role of these afferents during changes in the volume and composition of extracellular compartments. The present study sought to determine the involvement of these afferents in the renal vasodilation and sympathoinhibition induced by hypertonic saline (HS) infusion. Sinoaortic-denervated and sham male Wistar rats were anaesthetised with intravenous (i.v.) urethane (1.2 g/kg body weight (bw)) prior to the measurement of the mean arterial pressure (MAP), renal vascular conductance (RVC) and renal sympathetic nerve activity (RSNA). In the sham group, the HS infusion (3 mol/L NaCl, 1.8 mL/kg bw, i.v.) induced transient hypertension (12 ± 4 mmHg from baseline, peak at 10 min; P < 0.05), an increase in RVC (127 ± 9% and 150 ± 13% from baseline, at 20 and 60 min respectively; P < 0.05) and a decrease in RSNA (-34 ± 10% and -29 ± 5% from baseline, at 10 and 60 min respectively; P < 0.05). In sinoaortic-denervated rats, HS infusion promoted a sustained pressor response (30 ± 5 and 17 ± 6 mmHg of baseline values, at 10 and 30 min respectively; P < 0.05) and abolished the increase in RVC (85 ± 8% from baseline, at 10 min) and decrease in RSNA (-4 ± 3% from baseline, at 10 min). These results suggest that aortic and carotid afferents are involved in cardiovascular and renal sympathoinhibition responses induced by acute hypernatremia.
authors.affiliation: Centre for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Elaine F
authors.initials: EF
authors.lastname: Silva
authors.affiliation: Department of Physiology, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
authors.forename: Celisa T N
authors.initials: CT
authors.lastname: Sera
authors.affiliation: Centre for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Aline A
authors.initials: AA
authors.lastname: Mourão
authors.affiliation: Centre for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Paulo R
authors.initials: PR
authors.lastname: Lopes
authors.affiliation: Centre for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Marina C S
authors.initials: MC
authors.lastname: Moreira
authors.affiliation: Laboratory of Experimental Physiology, Faculty of Physical Education, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
authors.forename: Marcos L
authors.initials: ML
authors.lastname: Ferreira-Neto
authors.affiliation: Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil.
authors.forename: Débora A S
authors.initials: DA
authors.lastname: Colombari
authors.affiliation: Department of Physiology, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
authors.forename: Sérgio L D
authors.initials: SL
authors.lastname: Cravo
authors.affiliation: Centre for Neuroscience and Cardiovascular Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Gustavo R
authors.initials: GR
authors.lastname: Pedrino
mesh_terms: D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D001011:Aorta / Q000294:innervation*; D062186:Arterial Pressure; D017704:Baroreflex; D002346:Carotid Sinus / Q000294:innervation*; D004195:Disease Models, Animal; D006955:Hypernatremia / Q000097:blood / Q000503:physiopathology*; D007668:Kidney / Q000294:innervation*; D008297:Male; D009433:Neural Inhibition; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000503:physiopathology* / Q000601:surgery; D013997:Time Factors; D014664:Vasodilation
chemical_list: D012964:Sodium
keywords: arterial blood pressure; renal blood flow; sinoaortic denervation; sodium overload