title: Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants.
abstract: Reactive oxygen species mediate intestinal injury in necrotizing enterocolitis (NEC), and yet the contribution of antioxidant response (ARE) gene polymorphisms to NEC risk remains unknown. Premature infants recruited in a multicenter study were genotyped for 6 ARE variants. Among 637 infants, 52 had NEC, and 22 developed surgical NEC. Gestational age <28 weeks (P < 0.02) and African American race (P = 0.03) were associated with NEC. The NFE2L2 (rs6721961), SOD2 (rs4880), GSTP1 (rs1695), NQO1 (rs1800566), GCLC (rs17883901), and HMOX1 (rs2071747) variants were not associated with medical or surgical NEC. This study does not support a role for common deleterious ARE variants in NEC.
authors.affiliation: *Department of Pediatrics, Medical College of Wisconsin †Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, WI ‡Children's Hospitals and Clinics of Minnesota, Minneapolis §Department of Pediatrics, Iowa Children's Hospital, University of Iowa, Iowa City ¶Department of Pediatrics, Wheaton Franciscan Health Care, St Joseph Hospital, Milwaukee, WI.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Sampath
authors.forename: Daniel
authors.initials: D
authors.lastname: Helbling
authors.forename: Heather
authors.initials: H
authors.lastname: Menden
authors.forename: David
authors.initials: D
authors.lastname: Dimmock
authors.forename: Neil P
authors.initials: NP
authors.lastname: Mulrooney
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Murray
authors.forename: John M
authors.initials: JM
authors.lastname: Dagle
authors.forename: Jeffery S
authors.initials: JS
authors.lastname: Garland
mesh_terms: D061745:Antioxidant Response Elements / Q000235:genetics*; D000975:Antioxidants; D015331:Cohort Studies; D020345:Enterocolitis, Necrotizing / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D051267:NF-E2-Related Factor 2 / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies
chemical_list: D000975:Antioxidants; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human