title: Metabolic control of the cell cycle.
abstract: Cell division is a metabolically demanding process, requiring the production of large amounts of energy and biomass. Not surprisingly therefore, a cell's decision to initiate division is co-determined by its metabolic status and the availability of nutrients. Emerging evidence reveals that metabolism is not only undergoing substantial changes during the cell cycle, but it is becoming equally clear that metabolism regulates cell cycle progression. Here, we overview the emerging role of those metabolic pathways that have been best characterized to change during or influence cell cycle progression. We then studied how Notch signaling, a key angiogenic pathway that inhibits endothelial cell (EC) proliferation, controls EC metabolism (glycolysis) during the cell cycle.
authors.affiliation: a Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven ; Leuven , Belgium.|b Laboratory of Angiogenesis and Neurovascular link; Vesalius Research Center; VIB , Leuven , Belgium.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kalucka
authors.affiliation: a Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven ; Leuven , Belgium.|b Laboratory of Angiogenesis and Neurovascular link; Vesalius Research Center; VIB , Leuven , Belgium.
authors.forename: Rindert
authors.initials: R
authors.lastname: Missiaen
authors.affiliation: a Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven ; Leuven , Belgium.|b Laboratory of Angiogenesis and Neurovascular link; Vesalius Research Center; VIB , Leuven , Belgium.|c Present address: Turku Centre for Biotechnology ; Turku , Finland.
authors.forename: Maria
authors.initials: M
authors.lastname: Georgiadou
authors.affiliation: a Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven ; Leuven , Belgium.|b Laboratory of Angiogenesis and Neurovascular link; Vesalius Research Center; VIB , Leuven , Belgium.
authors.forename: Sandra
authors.initials: S
authors.lastname: Schoors
authors.affiliation: a Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven ; Leuven , Belgium.|b Laboratory of Angiogenesis and Neurovascular link; Vesalius Research Center; VIB , Leuven , Belgium.
authors.forename: Christian
authors.initials: C
authors.lastname: Lange
authors.affiliation: a Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven ; Leuven , Belgium.|b Laboratory of Angiogenesis and Neurovascular link; Vesalius Research Center; VIB , Leuven , Belgium.|d Present address: Exercise Physiology Research Group ; Department of Kinesiology ; KU Leuven ; Leuven , Belgium.
authors.forename: Katrien
authors.initials: K
authors.lastname: De Bock
authors.affiliation: a Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven ; Leuven , Belgium.|b Laboratory of Angiogenesis and Neurovascular link; Vesalius Research Center; VIB , Leuven , Belgium.
authors.forename: Mieke
authors.initials: M
authors.lastname: Dewerchin
authors.affiliation: a Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven ; Leuven , Belgium.|b Laboratory of Angiogenesis and Neurovascular link; Vesalius Research Center; VIB , Leuven , Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002135:Calcium-Binding Proteins; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism*; D049109:Cell Proliferation; D002478:Cells, Cultured; D004734:Energy Metabolism; D059585:G1 Phase Cell Cycle Checkpoints; D006019:Glycolysis; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D025481:Phosphofructokinase-2 / Q000235:genetics / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D014162:Transfection; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; C424126:DLL4 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D051880:Receptors, Notch; D044767:Ubiquitin-Protein Ligases; C107345:PFKFB3 protein, human; D025481:Phosphofructokinase-2
keywords: angiogenesis; cell cycle; endothelial cell; metabolism; quiescence