title: The role of mannose binding lectin on fever episodes in pediatric oncology patients.
abstract: Despite significant changes in pediatric oncological therapy, mortality is still high, mainly due to infections. Complement system as an ancient immune defense against microorganisms plays a significant role in surmounting infections, therefore, deficiency of its components may have particular importance in malignancies. The present paper assesses the effect of promoter (X/Y) and exon 1 (A/0) polymorphisms of the MBL2 gene altering mannose binding lectin (MBL) serum level in pediatric oncological patients with febrile neutropenia. Furthermore, frequency distribution of MBL2 alleles in children with malignancies and age-matched controls was analysed. Fifty-four oncohematological patients and 53 children who had undergone pediatric surgery were enrolled into this retrospective study. No significant differences were found in the frequency of MBL2 alleles between the hemato-oncologic and control group. The average duration of fever episodes was significantly shorter (p = 0.035) in patients carrying genotypes (AY/AY and AY/AX) that encode normal MBL level, compared to individuals with genotypes associated with lower functional MBL level (AX/AX, AY/0, AX/0, or 0/0) (days, median (IQ range) 3.7(0-5.4) vs. 5.0(3.8-6.6), respectively). In conclusion, our data suggest that MBL2 genotypes may influence the course of febrile neutropenia in pediatric patients with malignancies, and may contribute to clarification of the importance of MBL in infections.
authors.affiliation: Department of Hematology, Heim Pál Children's Hospital, Madarász Street Building, Madarász utca 22-24, Budapest, 1131, Hungary. efekete@heimpalkorhaz.hu.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Fekete
authors.affiliation: Department of Pediatric Surgery and Traumatology, Heim Pál Children's Hospital, Budapest, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Fadgyas
authors.affiliation: National Institute of Psychiatry and Addictions, Gyula Nyírő Hospital, Budapest, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Papp
authors.affiliation: 3rd Department of Internal Medicine, Research Laboratory, Semmelweis University, Budapest, Hungary.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Szilágyi
authors.affiliation: 3rd Department of Internal Medicine, Research Laboratory, Semmelweis University, Budapest, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Prohászka
authors.affiliation: Department of Hematology, Heim Pál Children's Hospital, Madarász Street Building, Madarász utca 22-24, Budapest, 1131, Hungary.
authors.forename: Brigitta
authors.initials: B
authors.lastname: Müller
authors.affiliation: 2nd Department of Pediatrics, Hematology Unit, Semmelweis University, Budapest, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Kovács
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D064147:Febrile Neutropenia / Q000097:blood / Q000235:genetics* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000235:genetics*; D009367:Neoplasm Staging; D009369:Neoplasms / Q000097:blood / Q000235:genetics* / Q000601:surgery; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin
keywords: Febrile neutropenia; MBL; Oncohematology; Polymorphism