title: ncRNA-regulated immune response and its role in inflammatory lung diseases.
abstract: Despite the greatly expanded knowledge on the regulation of immune response by protein molecules, there is increasing understanding that noncoding RNAs (ncRNAs) are also an integral component of this regulatory network. Abnormal immune response serves a central role in the initiation, progression, and exacerbation of inflammatory lung diseases, such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, and acute respiratory distress syndrome/acute lung injury. Dysregulation of ncRNAs has been linked to various immunopathologies. In this review, we highlighted the role of ncRNAs in the regulation of innate and adaptive immunity and summarized recent findings that ncRNAs participate in the pathogenesis of inflammatory lung diseases via their regulation of pulmonary immunity. We also discussed therapeutic potentials for targeting ncRNAs to treat these lung disorders.
authors.affiliation: Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Na
authors.initials: N
authors.lastname: Xie
authors.affiliation: Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama gliu@uab.edu.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001249:Asthma / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D003550:Cystic Fibrosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008168:Lung / Q000276:immunology / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D034622:RNA Interference; D022661:RNA, Untranslated / Q000502:physiology*; D012128:Respiratory Distress Syndrome / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D022661:RNA, Untranslated
keywords: acute respiratory distress syndrome; asthma; chronic obstructive pulmonary disease; cystic fibrosis; immunity; noncoding ribonucleic acid