title: TYPE 2 NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
abstract: OBJECTIVE
  Optical coherence tomography angiography is a novel and noninvasive technique for imaging retinal microvasculature by detecting changes in reflectivity that is related to blood flow. The purpose of this study was to describe Type 2 neovascularization characteristics in age-related macular degeneration using optical coherence tomography angiography.
  
  
  METHODS
  Fourteen eyes of 14 consecutive patients with Type 2 neovascularization were prospectively included. All patients underwent a complete ophthalmological examination, including color and infrared fundus photography, fluorescein and indocyanine green angiography, spectral domain optical coherence tomography angiography, and optical coherence tomography angiography.
  
  
  RESULTS
  In all cases, Type 2 lesions could be detected by optical coherence tomography angiography, presenting as a hyperflow lesion in the outer retina, with a glomerulus (4/14) or medusa shape (10/14), surrounded by a dark halo. The superficial layer and the deep retina showed no abnormal flow. Surprisingly, the Type 2 lesions could also be observed in the presumed choriocapillaris layer. These glomerulus- or medusa-shaped lesions were connected, in 10/14 eyes, to a thicker main branch, which seemed to continue deep into the choroidal layers.
  
  
  CONCLUSIONS
  Optical coherence tomography angiography may be a new imaging method for the diagnosis of Type 2 neovascularization in clinical routine. However, the specificity of the features needs to be investigated in further studies.
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Université Paris Est, Créteil, France.
authors.forename: Ala
authors.initials: A
authors.lastname: El Ameen
authors.forename: Salomon Y
authors.initials: SY
authors.lastname: Cohen
authors.forename: Oudy
authors.initials: O
authors.lastname: Semoun
authors.forename: Alexandra
authors.initials: A
authors.lastname: Miere
authors.forename: Mayer
authors.initials: M
authors.lastname: Srour
authors.forename: Maddalena
authors.initials: M
authors.lastname: Quaranta-El Maftouhi
authors.forename: Hassiba
authors.initials: H
authors.lastname: Oubraham
authors.forename: Rocio
authors.initials: R
authors.lastname: Blanco-Garavito
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D020256:Choroidal Neovascularization / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012039:Regional Blood Flow; D041623:Tomography, Optical Coherence / Q000379:methods*; D057135:Wet Macular Degeneration / Q000150:complications / Q000175:diagnosis*