title: Involvement of Neuroactive Steroids in Pain, Depression and Anxiety.
abstract: Comorbidity between major depressive disorder (MDD), anxiety (generalized anxiety, panic disorder, social anxiety disorder) and pain is a major complicating factor in the diagnosis and treatment of psychiatric and neurological disorders. Although numerous neurotransmitters and/or neuromodulators may be involved, abnormalities in the GABAergic and glutamatergic systems seem to be a common factor in all these disorders. Neuroactive steroids (NASs) have been the object of considerable interest in this area in recent years since they appear to act predominantly on GABA-A and glutamate NMDA receptors. An overview of the possible involvement of NASs in MDD, anxiety and pain is provided in this chapter.
authors.forename: Katherine
authors.initials: K
authors.lastname: Mifflin
authors.forename: Curtis
authors.initials: C
authors.lastname: Benson
authors.forename: Bradley
authors.initials: B
authors.lastname: Kerr
authors.forename: Feyza
authors.initials: F
authors.lastname: Aricioglu
authors.forename: Mesut
authors.initials: M
authors.lastname: Cetin
authors.forename: Serdar
authors.initials: S
authors.lastname: Dursun
authors.forename: Glen
authors.initials: G
authors.lastname: Baker
mesh_terms: D000818:Animals; D001008:Anxiety Disorders / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009437:Neuralgia / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013256:Steroids / Q000378:metabolism*
chemical_list: D018377:Neurotransmitter Agents; D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate; D013256:Steroids