title: Investigation Of Chromium-Cobalt Coated Scaffolds On Cell Cultures In Vitro.
abstract: The use of diverse materials for medical purposes is continuously expanding. The modification of materials which are routinely applied in medical practice as well as the development and introduction of new materials require studies on their biological activity. The first steps in this process are the preliminary short-term screening tests for cytotoxicity and biocompatibility performed on cell cultures.
  
  
  
  Coating of stainless steel (316 L) scaffolds with chromium-cobalt was performed by electroplating using the non-standard electrolyte Chromispel. The process was carried through at different cathode current densities and deposition times. The modified surface of the metal scaffolds was studied for cytoxicity and cell vitality on the serum-free McCoy-Plovdiv and the immortalized PDL cell cultures.
  
  
  
  Our results indicate no cytotoxic effect of the coated metal scaffolds. Even more, three of the samples stimulated the proliferation and growth of McCoy-Plovdiv cells.
  
  
  
  We have strong reasons to believe that chromium-cobalt coatings are promising for future studies and reliable for medical purposes.
authors.affiliation: Department of Chemistry and Biochemistry, Faculty of Pharmacy
authors.forename: Denitsa D
authors.initials: DD
authors.lastname: Kiradzhiyska
authors.affiliation: Department of Chemistry and Biochemistry, Faculty of Pharmacy
authors.forename: Rositsa D
authors.initials: RD
authors.lastname: Mantcheva
authors.affiliation: Department of Languages and Specialized Training, Section of Natural Sciences
authors.forename: Detelina L
authors.initials: DL
authors.lastname: Mileva
authors.affiliation: Department of Microbiology and Immunology, Faculty of Pharmacy
authors.forename: Krasimira I
authors.initials: KI
authors.lastname: Draganova
authors.affiliation: Department of Medical Biology, Medical Faculty, Medical University, Plovdiv, Bulgaria
authors.forename: Yana N
authors.initials: YN
authors.lastname: Feodorova
authors.affiliation: Department of Medical Biology, Medical Faculty, Medical University, Plovdiv, Bulgaria
authors.forename: Victoria S
authors.initials: VS
authors.lastname: Sarafan
authors.affiliation: Department of Medical Biology, Medical Faculty, Medical University, Plovdiv, Bulgaria
authors.forename: Marian M
authors.initials: MM
authors.lastname: Draganov
mesh_terms: D001672:Biocompatible Materials; D018929:Cell Culture Techniques; D002460:Cell Line; D002470:Cell Survival; D002858:Chromium Alloys; D004595:Electroplating; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D013193:Stainless Steel; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D002858:Chromium Alloys; D013193:Stainless Steel