title: Use of Spongostan™ for Prevention of Cranial Subdural Adhesions Following Craniotomy in an Experimental Rabbit Model.
abstract: OBJECTIVE
  Spongostan™ is a sterile, water-insoluble, porcine gelatin absorbable sponge, which is widely used as a hemostatic material. The aim of this study is to test the anti-fibrotic capacity of Spongostan™, using a craniotomy model in an experimental rabbit model.
  
  
  METHODS
  Eighteen rabbits were divided into two groups: Each group consisted of 9 rabbits, duratomy plus Spongostan™ (group 1), and duratomy without Spongostan™ (group 2). Right parietal bone was removed via trephine and low speed drill and dura was opened. On the group 1 rabbits, an appropriate piece of Spongostan™ was meticulously placed under dural layer. On group 2 rabbits, same procedures were repeated without Spongostan™. Histological sections were taken from each group and evaluated for degree of fibrosis and collagen fibers.
  
  
  RESULTS
  There was marked increase in number of fibroblasts and collagen fibers in group 2 rabbits, however most of the rabbits in Spongostan™ group demonstrate scarce histopathological findings for fibrosis.
  
  
  CONCLUSIONS
  We conclude that an appropriately placed subdural Spongostan™ over cerebral tissue may prevent postoperative surgical adhesions after neurosurgical operations.
authors.affiliation: Antalya Education and Research Hospital, Department of Neurosurgery, Antalya, Turkey.
authors.forename: Cagatay
authors.initials: C
authors.lastname: Ozdol
authors.forename: Fatih
authors.initials: F
authors.lastname: Alagoz
authors.forename: Ali Erdem
authors.initials: AE
authors.lastname: Yildirim
authors.forename: Murat
authors.initials: M
authors.lastname: Korkmaz
authors.forename: Ergun
authors.initials: E
authors.lastname: Daglioglu
authors.forename: Pergin
authors.initials: P
authors.lastname: Atilla
authors.forename: Sevda
authors.initials: S
authors.lastname: Muftuoglu
authors.forename: Ahmet Deniz
authors.initials: AD
authors.lastname: Belen
mesh_terms: D000818:Animals; D003399:Craniotomy / Q000009:adverse effects*; D004388:Dura Mater / Q000601:surgery; D005355:Fibrosis / Q000517:prevention & control; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use*; D011817:Rabbits; D012886:Skull / Q000601:surgery; D013355:Subdural Space / Q000473:pathology* / Q000601:surgery; D013552:Swine; D000267:Tissue Adhesions / Q000517:prevention & control*