title: Efficient, Solvent-Free, Multicomponent Method for Organic-Base-Catalyzed Synthesis of β-Phosphonomalonates.
abstract: An efficient, one-pot, di-n-butylamine-catalyzed, three-component synthesis of β-phosphonomalonates has been developed. A wide range of substrates, including aromatic and fused aromatic aldehydes, were condensed with enolizable C-H activated compounds and dialkylphosphites to give the desired products in excellent yields. This method provides an eco-friendly alternative approach to rapid construction of a diversity-oriented library of β-phosphonomalonates.
authors.affiliation: BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, ‡Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University , Busan 609-735, Republic of Korea.
authors.forename: Reddi Mohan Naidu
authors.initials: RM
authors.lastname: Kalla
authors.affiliation: BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, ‡Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University , Busan 609-735, Republic of Korea.
authors.forename: Huiju
authors.initials: H
authors.lastname: Park
authors.affiliation: BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, ‡Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University , Busan 609-735, Republic of Korea.
authors.forename: Hye Ri
authors.initials: HR
authors.lastname: Lee
authors.affiliation: BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, ‡Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University , Busan 609-735, Republic of Korea.
authors.forename: Hongsuk
authors.initials: H
authors.lastname: Suh
authors.affiliation: BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, ‡Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University , Busan 609-735, Republic of Korea.
authors.forename: Il
authors.initials: I
authors.lastname: Kim
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002082:Butylamines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry
chemical_list: D000447:Aldehydes; D002082:Butylamines; D009570:Nitriles; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C045274:dibutylamine
keywords: multicomponent reaction; organocatalyst; solvent-free; β-phosphonomalonate