title: The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair.
abstract: Damage to mitochondria is a common mechanism of cell death in inherited neurodegenerative disorders. Therefore, mitochondrial protection and mitochondrial repair are promising strategies to induce retinal neuroprotection. Peroxisome proliferator-activated receptor γ coactivator-α (PGC-1α) and β (PGC-1β) are transcriptional coactivators that are the main regulators of mitochondrial biogenesis. We propose that PGC-1α and PGC-1β could play a role in regulating retina cell survival, and may be important therapeutic targets to prevent retinal degeneration.
authors.affiliation: Department of Environmental Horticulture Research, University of Florida, Gainesville, FL 32611-0670, USA.  cabrahan@ufl.edu
authors.forename: Carolina
authors.initials: C
authors.lastname: Abrahan
authors.affiliation: Department of Ophthalmology, University of Florida, ARB-RG232, 1600 SW Archer Rd, 32610, Gainesville, FL, USA. jash@ufl.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: Ash
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism*; D002470:Cell Survival; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D001678:Organelle Biogenesis; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D016601:RNA-Binding Proteins; D017382:Reactive Oxygen Species / Q000378:metabolism; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D012162:Retinal Degeneration / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D004272:DNA, Mitochondrial; C486497:PPARGC1A protein, human; C455622:PPARGC1B protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D016601:RNA-Binding Proteins; D017382:Reactive Oxygen Species; D014157:Transcription Factors
keywords: Mitochondrial biogenesis; Neuroprotection; PGC-1alpha; PGC-1beta; Retina