title: A curcumin activated carboxymethyl cellulose-montmorillonite clay nanocomposite having enhanced curcumin release in aqueous media.
abstract: A novel curcumin activated carboxymethylcellulose-montmorillonite nanocomposite is reported. A superabsorbent biopolymer; carboxymethyl cellulose (CMC) was used as an emulsifier for curcumin which is a turmeric derived water insoluble polyphenolic compound with antibacterial/anti-cancer properties. Montmorillonite (MMT) nanoclay was incorporated in the formulation as a matrix material which also plays a role in release kinetics. It was observed that water solubility of curcumin in the nanocomposite has significantly increased (60% release within 2h and 30 min in distilled water at pH 5.4) compared to pure curcumin. The prepared curcumin activated carboxymethylcellulose-montmorillonite nanocomposite is suitable as a curcumin carrier having enhanced release and structural properties.
authors.affiliation: Sri Lanka Institute of Nanotechnology (SLINTEC), Nanotechnology and Science Park, Mahenwatta, Pitipana, Homagama, Sri Lanka; Department of Engineering, University of Cambridge, Cambridge, UK.
authors.forename: Nadeesh
authors.initials: N
authors.lastname: Madusanka
authors.affiliation: Sri Lanka Institute of Nanotechnology (SLINTEC), Nanotechnology and Science Park, Mahenwatta, Pitipana, Homagama, Sri Lanka; Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka. Electronic address: nalinds@slintec.lk.
authors.forename: K M Nalin
authors.initials: KM
authors.lastname: de Silva
authors.affiliation: Sri Lanka Institute of Nanotechnology (SLINTEC), Nanotechnology and Science Park, Mahenwatta, Pitipana, Homagama, Sri Lanka; Department of Engineering, University of Cambridge, Cambridge, UK.
authors.forename: Gehan
authors.initials: G
authors.lastname: Amaratunga
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry; D001546:Bentonite / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D007700:Kinetics; D053761:Nanocomposites / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004337:Drug Carriers; D014867:Water; D001546:Bentonite; D003474:Curcumin; D002266:Carboxymethylcellulose Sodium
keywords: Carboxymethylcellulose; Clay; Curcumin; Nanocomposite