title: Once-a-day Tadalafil administration improves the spermogram parameters in fertile patients.
abstract: OBJECTIVE
  We explored the safety of Tadalafil once-daily treatment for 12 week and its effects on semen quality in a clinical subpopulation of men with psychogenic erectile dysfunction (ED).
  
  
  METHODS
  Twenty-seven men, between 19 and 35 years, unaware of their fertility status, suffering from psychogenic ED were enrolled. The examination of the seminal fluid was performed twice before administration of Tadalafil and twice after three months of continuous daily administration of Tadalafil 5 mg. The volume of the seminal fluid, the concentration of sperm, the concentration of sperm with type "a+b" motility, the concentration of sperm with type "a" motility, the concentration of normal sperm were taken into consideration. The results before treatment with Tadalafil (T0) and after 3 months of treatment (T3m) were compared.
  
  
  RESULTS
  The administration of once-daily Tadalafil 5mg, brings to an average increase of the total number of sperm cells, both total and fast motility (type a) and the percentage of nemasperms, and to an average increase of semen volume of only 0.41 ml. These quantitative and qualitative improvements of the seminal fluid resulted statistically significant as regard motility, nemasperm percentage and seminal fluid volume. No unespected safety findings were observed.
  
  
  CONCLUSIONS
  Tadalafil administration improves the quality of sperm cells and seminal fluid: in particular motility, percentage of nemasperms and volume of seminal fluid. We emphasize the safety of the once-daily treatment with tadalafil 5mg and the positive effects on spermatogenesis.
authors.affiliation: Unit of Urology, "L. Bonomo" Hospital, ASL BAT, Andria; Centre of Andrology and Reproductive Pro.Andròs certified ISO 9001-2008 certified SIA. peppealbino@hotmail.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Corvasce
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Albino
authors.forename: Teresa
authors.initials: T
authors.lastname: Leonetti
authors.forename: Agnese Filomena
authors.initials: AF
authors.lastname: Buonomo
authors.forename: Ettore Cirillo
authors.initials: EC
authors.lastname: Marucco
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D058986:Phosphodiesterase 5 Inhibitors / Q000008:administration & dosage*; D013094:Spermatozoa / Q000187:drug effects*; D000068581:Tadalafil / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil