title: The impact of environmental and biological factors on paraoxonase 1 and γ-glutamyltranspeptydase activities in the blood of smelters.
abstract: Disorders of paraoxonase and γ-glutamyltranspeptydase activities can induce development of the atherosclerotic process. The aim of the study was to examine the effect of occupational exposure to heavy metals, tobacco smoke and alcohol consumption on the activities of paraoxonase and γ-glutamyltranspeptydase as well as glutathione concentration. We have observed reduced paraoxonase activity and higher γ-glutamyltranspeptydase activity in serum of smelters when compared to control groups. In the blood of smoking smelters was demonstrated a negative correlation between paraoxonase activity and BMI value as well as between paraoxonase activity and tobacco smoke and consumption of 40% alcohol. Also, negative correlation was found for the activity of paraoxonase and glutathione concentration as well as γ-glutamyltranspeptydase activity. Higher γ-glutamyltranspeptydase activity and lower paraoxonase activity in the serum of smelters exposed to heavy metals and tobacco smoke can cause disorders in functioning of the body.
authors.affiliation: a Faculty of Pharmacy, Department of Biomedical and Environmental Analysis , Wroclaw Medical University , Wrocław , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Bizoń
authors.affiliation: a Faculty of Pharmacy, Department of Biomedical and Environmental Analysis , Wroclaw Medical University , Wrocław , Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Kepinska
authors.affiliation: b Faculty of Pharmacy, Students Scientific Society at the Department of Biomedical Environmental Analysis , Wroclaw Medical University , Wrocław , Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Snacki
authors.affiliation: a Faculty of Pharmacy, Department of Biomedical and Environmental Analysis , Wroclaw Medical University , Wrocław , Poland.
authors.forename: Halina
authors.initials: H
authors.lastname: Milnerowicz
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004784:Environmental Monitoring; D006801:Humans; D008297:Male; D008669:Metallurgy; D019216:Metals, Heavy / Q000009:adverse effects*; D008875:Middle Aged; D016273:Occupational Exposure; D011044:Poland; D012907:Smoking / Q000009:adverse effects*; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D019216:Metals, Heavy; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: cadmium; exposure; heavy metals; occupational hazards