title: Spatially, Temporally, and Quantitatively Controlled Delivery of Broad Range of Molecules into Selected Cells through Plasmonic Nanotubes.
abstract: A Universal plasmonic/microfluidic platform for spatial and temporal controlled intracellular delivery is described. The system can inject/transfect the desired amount of molecules with an efficacy close to 100%. Moreover, it is highly scalable from single cells to large ensembles without administering the molecules to an extracellular bath. The latter enables quantitative control over the amount of injected molecules.
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Gabriele C
authors.initials: GC
authors.lastname: Messina
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Dipalo
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: La Rocca
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Zilio
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Caprettini
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Remo
authors.initials: R
authors.lastname: Proietti Zaccaria
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Toma
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Tantussi
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Berdondini
authors.affiliation: Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Angelis
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D042541:Intracellular Space / Q000378:metabolism; D056656:Lab-On-A-Chip Devices; D007834:Lasers; D051379:Mice; D041681:NIH 3T3 Cells; D043942:Nanotubes; D061848:Optical Imaging; D062211:Spatio-Temporal Analysis
keywords: hot electrons; intracellular delivery; optofluidics; optoporation; plasmonics