title: [Prostatic inflammation-induced chronic pelvic pain: Roles of substance P and c-fos in the spinal cord].
abstract: OBJECTIVE
  To explore the possible pain mechanism of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
  
  
  METHODS
  The models of CP/CPPS were established in male Wistar rats by the autoimmune method. The paw withdrawal threshold (PWT) was detected using Von Frey filament. The expressions of the substance P and c-fos in the prostate and spinal L5-S2 segments were determined by immunohistochemistry followed by analysis of their correlation with CP/CPPS.
  
  
  RESULTS
  Compared with the control rats, the CP/CPPS models showed significantly decreased PWT (P < 0.05), remarkable prostatic inflammation, enlarged scope of lesions, and obvious interstitial lymphocytic infiltration (P < 0.05). Both the expressions of substance P and c-fos were markedly elevated in the prostate and spinal dorsal horn (L5-S2) of the rat models (P < 0.05), but the expression of substance P in the prostate exhibited no correlation with that in the spinal cord (r = 0.099, P = 0.338), nor did that of c-fos (r = 0.027, P = 0.454).
  
  
  CONCLUSIONS
  The upregulated expressions of substance P and c-fos in the spinal cord L5-S2 sections may be associated with the pain mechanism of CP/CPPS.
authors.forename: Ying-jia
authors.initials: YJ
authors.lastname: Liu
authors.forename: Guo-hong
authors.initials: GH
authors.lastname: Song
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002908:Chronic Disease; D007150:Immunohistochemistry; D008297:Male; D017699:Pelvic Pain / Q000209:etiology* / Q000378:metabolism; D011467:Prostate / Q000378:metabolism*; D011472:Prostatitis / Q000150:complications* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D013577:Syndrome; D015854:Up-Regulation
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D013373:Substance P