title: Acquired cutis laxa associated with cutaneous mastocytosis.
abstract: Cutis laxa is characterized by dramatic wrinkling of skin that is lacking in elasticity due to inherent defects in dermal elastic fibers. Cutis laxa can be caused by genetic and metabolic disorders. It can also be acquired, possibly resulting from inflammatory processes with destruction of elastic fibers. This report describes a 26-year old woman who developed acquired cutis laxa and cutaneous mastocytosis leading to premature aging. She represents a unique co-occurrence of these two separate disease entities. To our knowledge, there has been only one published case report of acquired cutis laxa occurring in association with urticaria pigmentosa in a 4-year old girl. Our case would be a second case that exhibits the coexistence of these two disorders in an adult female.
authors.forename: Minh Van
authors.initials: MV
authors.lastname: Hoang
authors.forename: Phuoc Van
authors.initials: PV
authors.lastname: Dang
authors.forename: Duc Van
authors.initials: DV
authors.lastname: Bui
authors.forename: Haider
authors.initials: H
authors.lastname: Mejbel
authors.forename: Divya Thomas
authors.initials: DT
authors.lastname: Mani
authors.forename: Bruce Robert
authors.initials: BR
authors.lastname: Smoller
authors.affiliation: Texas Children's Hospital, Houston.
authors.forename: Thuy Linh
authors.initials: TL
authors.lastname: Phung
mesh_terms: D019588:Aging, Premature / Q000209:etiology* / Q000503:physiopathology; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D003483:Cutis Laxa / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D018450:Disease Progression; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D034701:Mastocytosis, Cutaneous / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012720:Severity of Illness Index; D015595:Skin Aging