title: Evaluation of Anti-inflammatory and Some Possible Mechanisms of Antinociceptive Effect of Ferula assa foetida Oleo Gum Resin.
abstract: Asafetida is well known for its medicinal and therapeutic values in Iranian folk medicine. This study was conducted to investigate the antinociceptive and anti-inflammatory effects of asafetida. In hot plate test, asafetida exhibited a significant antinociceptive effect at all administered doses and the most effective dose was 10 mg/kg. The highest maximum potent effect was observed 15 minutes after asafetida administration. The antinociceptive effect of asafetida was not reversed by administration of any antagonist used in this study but asafetida showed a remarkable antioxidant and also inhibitory action against lipoxygenase activity. Paw weight was significantly reduced only in treated animals with 2.5 mg/kg asafetida. Results clearly indicate that the asafetida could be a potential source of anti-inflammatory and analgesic agent. These effects may be due to its effective constituents such as monoterpenes, flavonoids and phenolic components that have antioxidant properties and inhibit lipoxygenase activity.
authors.affiliation: Department of Physiology, Shahid Sadoghi University of Medical Sciences, Yazd, Iran boss_bagheri@yahoo.com.
authors.forename: Seyyed Majid
authors.initials: SM
authors.lastname: Bagheri
authors.affiliation: School of Medicine, Shahid Sadoghi University of Medical Sciences, Yazd, Iran.
authors.forename: Sadegh Taghizade
authors.initials: ST
authors.lastname: Hedesh
authors.affiliation: Department of Anatomy, Shahid Sadoghi University of medical Sciences, Yazd, Iran.
authors.forename: Aghdas
authors.initials: A
authors.lastname: Mirjalili
authors.affiliation: Neurobiomedical Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Dashti-R
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000032:analysis / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D004487:Edema; D005309:Ferula / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D059408:Pain Management; D010147:Pain Measurement; D053149:Plant Gums / Q000737:chemistry / Q000494:pharmacology; D012116:Resins, Plant / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D053149:Plant Gums; D012116:Resins, Plant; D019342:Acetic Acid
keywords: analgesic; anti-inflammatory; antioxidant; asafetida; lipoxygenase