title: Expression of Matrix Metalloproteinase-10 at Invasive Front of Squamous Cell Carcinoma and Verrucous Carcinoma in the Oral Cavity.
abstract: BACKGROUND
  Matrix metalloproteinases (MMPs) are a family of zinc metalloproteinases capable of degrading components of connective tissues. MMP-10 is frequently expressed in human cancers. The aim of this study was to immunohistochemically evaluate its expression in oral squamous cell carcinoma (OSCC) and verrucous carcinoma (OVC).
  
  
  METHODS
  A retrospective analysis of 73 samples (31 OSCC, 22 OVC and 20 non-neoplastic epithelium) was performed. All samples were immunohistochemically stained with monoclonal MMP-10 antibody and expression levels and staining intensity were evaluated with respect to microscopic features. Data were analyzed by SPSS (V.21), Mann-Whitney and Kruskal Wallis tests.
  
  
  RESULTS
  MMP-10 was detected in all OSCC and OVC cases. The expression of MMP-10 in OSCC was intensive (score 3) and in OVC was low and moderate (score 1 and score 2) more frequently. Non- neoplastic epithelium did not show MMP-10 expression. Differences between groups was statistically significant (p<0.05). However, the expression of MMP- 10 was not obviously different between various grades of OSCC.
  
  
  CONCLUSIONS
  According to our study, MMP-10 protein can be important possible factor in the transformation of normal oral epithelium to OVC and OSCC, also the level of MMP-10 expression at invasion front of the lesions can be helpful in the differentiation of OVC and OSCC.
authors.affiliation: Oral and DentalDisease Research Center, Dept of Oral and Maxillofacial Pathology, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran E-mail : Shirin.Saravani@gmail.com.
authors.forename: Hamideh
authors.initials: H
authors.lastname: Kadeh
authors.forename: Shirin
authors.initials: S
authors.lastname: Saravani
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Heydari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Keikha
authors.forename: Vahab
authors.initials: V
authors.lastname: Rigi
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000201:enzymology* / Q000473:pathology*; D018289:Carcinoma, Verrucous / Q000737:chemistry / Q000201:enzymology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D053506:Matrix Metalloproteinase 10 / Q000032:analysis*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000737:chemistry / Q000201:enzymology; D009062:Mouth Neoplasms / Q000737:chemistry / Q000201:enzymology* / Q000473:pathology*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies
chemical_list: D053506:Matrix Metalloproteinase 10