title: Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway.
abstract: The control of cell division is essential for normal development and the maintenance of cellular homeostasis. Abnormal cell proliferation is associated with multiple pathological states, including cancer. Although the Hippo/YAP signaling pathway was initially thought to control organ size and growth, increasing evidence indicates that this pathway also plays a major role in the control of proliferation independent of organ size control. In particular, accumulating evidence indicates that the Hippo/YAP signaling pathway functionally interacts with multiple other cellular pathways and serves as a central node in the regulation of cell division, especially in cancer cells. Here, recent observations are highlighted that connect Hippo/YAP signaling to transcription, the basic cell-cycle machinery, and the control of cell division. Furthermore, the oncogenic and tumor-suppressive attributes of YAP/TAZ are reviewed, which emphasizes the relevance of the Hippo pathway in cancer.
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, Stanford, California. Department of Genetics, Stanford University School of Medicine, Stanford, California. Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany. ursula.ehmer@tum.de.
authors.forename: Ursula
authors.initials: U
authors.lastname: Ehmer
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, Stanford, California. Department of Genetics, Stanford University School of Medicine, Stanford, California.
authors.forename: Julien
authors.initials: J
authors.lastname: Sage
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D002455:Cell Division; D049109:Cell Proliferation; D000090683:Hippo Signaling Pathway; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D010750:Phosphoproteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors; D014158:Transcription, Genetic; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D017346:Protein Serine-Threonine Kinases