title: What risk of prostate cancer led urologist to recommend prostate biopsies?
abstract: OBJECTIVE
  The aim of this study was to estimate the risk of prostate cancer that led urologists to perform prostate biopsies.
  
  
  METHODS
  Eight hundred and eight patients had prostate biopsies in 5 tertiary centres in 2010. Following data were collected: age, PSA, DRE, prostate volume, negative prior prostate biopsy and estimated life expectancy (> or <10 years). The risk of prostate cancer was calculated by validated nomogram of PCPT-CRC and SWOP-PRI and correlated with pathological biopsy results.
  
  
  RESULTS
  In final analysis, 625 patients were included, 568 (90.9%) had a life expectancy greater than 10 years. Prostate cancer was found in 291 (46.6%) cases. These patients were older (66.7 ± 6.8 vs 64.3 ± 5.6 years, P < 0.001), had higher PSA values (10 ± 7.9 vs 7.7 ± 4.3 ng/mL, P < 0.0001) and the prostate volume decreased (43.8 ± 19.8 vs 51.3 ± 20.7 mL, P < 0.0001) compared with healthy subjects. Digital Rectal Examination was more frequently suspicious in the group of patients with prostate cancer (43.6% vs 18.9%, P < 0.0001). Risk of prostate cancer estimated was 50.6 ± 14% for PCPT-CRC without ATCD, 56.2 ± 12.8% with PCPT-CRC ATCD and 31.2 ± 17.3% for SWOP-PRI. The likelihood of high-risk prostate cancer was 22.4 ± 16.9% with the PCPT-CRC, and 14.8 ± 18.2% with SWOP-PRI.
  
  
  CONCLUSIONS
  This study showed that urologists performed prostate biopsies when the risk of cancer was high.
authors.affiliation: Département d'urologie, CHU Rangueil, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex France. Electronic address: roumiguie_mathieu@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Roumiguié
authors.affiliation: Département d'urologie, CHU Rangueil, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Beauval
authors.affiliation: Clinique Pasteur, service d'urologie, 5, avenue de Lombez, 31300 Toulouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Bordier
authors.affiliation: Département de biostatistiques, IUCT oncopôle, Toulouse, France.
authors.forename: T
authors.initials: T
authors.lastname: Filleron
authors.affiliation: Institut Montsouris, département d'urologie, 42, boulevard Jourdan, 75014 Paris cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Rozet
authors.affiliation: Département d'urologie, centre hospitalier Lyon Sud, Pierre-Bénite, France.
authors.forename: A
authors.initials: A
authors.lastname: Ruffion
authors.affiliation: Département d'urologie, hôpital Nord, 42055 Saint-Étienne cedex 2, France.
authors.forename: N
authors.initials: N
authors.lastname: Mottet
authors.affiliation: Département d'urologie, hôpital Tenon, CHU, AP-HP, 4, rue de la Chine, 75970 Paris cedex 20, France.
authors.forename: O
authors.initials: O
authors.lastname: Cussenot
authors.affiliation: Département d'urologie, CHU Rangueil, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex France; Département de biostatistiques, IUCT oncopôle, Toulouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Malavaud
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D000066491:Clinical Decision-Making; D006801:Humans; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians'; D011471:Prostatic Neoplasms / Q000473:pathology*; D018570:Risk Assessment; D014572:Urology
keywords: Biopsies; Biopsy; Cancer de prostate; Diagnosis; Diagnostic; Nomogram; Nomogramme; Prostate cancer; Risk; Risques