title: Cellular imaging: a key phenotypic screening strategy for predictive toxicology.
abstract: Incorporating phenotypic screening as a key strategy enhances predictivity and translatability of drug discovery efforts. Cellular imaging serves as a "phenotypic anchor" to identify important toxicologic pathology that encompasses an array of underlying mechanisms, thus provides an effective means to reduce drug development failures due to insufficient safety. This mini-review highlights the latest advances in hepatotoxicity, cardiotoxicity, and genetic toxicity tests that utilized cellular imaging as a screening strategy, and recommends path forward for further improvement.
authors.affiliation: Merck and Co. Kenilworth, NJ, USA.
authors.forename: Jinghai J
authors.initials: JJ
authors.lastname: Xu
keywords: cardiotoxicity; cellular imaging; discovery toxicology; genetic toxicology; hepatotoxicity; phenotypic screening; predictive toxicology