title: Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum.
abstract: Background. Medulloblastoma, although the most common brain tumor of childhood, is exceedingly rare in adults. These tumors have a propensity for local recurrence and to metastasize along the leptomeninges; however, extraneural metastases are very rare and typically occur in the bone or bone marrow. We have not come across any case in literature of medulloblastoma with mediastinal metastases in an adult. Case Presentation. We report a case of medulloblastoma in a 38-year-old lady who was treated with surgery followed by craniospinal radiation. Ten years later she presented with hoarseness from true vocal cord paralysis. She was diagnosed to have infiltrating metastases of her medulloblastoma to the mediastinum, which was confirmed by biopsy. There was no local recurrence. This was treated with chemotherapy followed by stem cell rescue, and she remained progression free for 2 years. Conclusion. Medulloblastomas are rare in adults and can present with late extraneural metastases following treatment. Although most common reported sites are bone and bone marrow, late metastases to other unexpected areas like the mediastinum are possible too and warrant awareness. This can be treated with chemotherapy followed by high-dose chemotherapy and stem cell rescue in a young patient with good performance status.
authors.affiliation: University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Abhimanyu
authors.initials: A
authors.lastname: Ghose
authors.affiliation: University of Cincinnati, Cincinnati, OH, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.affiliation: University of Cincinnati, Cincinnati, OH, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Breneman
authors.affiliation: Oncology Hematology Care Inc, Cincinnati, OH, USA.
authors.forename: James
authors.initials: J
authors.lastname: Essell
authors.affiliation: University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wang
authors.affiliation: University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Sadia
authors.initials: S
authors.lastname: Benzaquen
keywords: adult; extraneural; mediastinum; medulloblastoma; metastasis