title: Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network.
abstract: Mucin networks are lubricous biofunctional coats formed through the continuous deposition of mucin glycoproteins. Previously, we demonstrated the synthesis of a mucin mimic using biotinylated-filomicelles crosslinked via streptavidin using a layer-by-layer approach. These networks recreate the fibrous nature of mucin and can serve as a drug-releasing network. In this work, the ability to vary the network properties by blending filomicelles with spherical micelles is demonstrated. In addition, the deposition of a dense polymer coating on the mucin network was shown to act as a barrier to control diffusion and improved the structural stability under simulated oral chemical conditions. These biomimetic coatings can be utilized as a delivery system, providing a tunable drug release for oral applications.
authors.affiliation: Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, Kentucky, 40506, USA.
authors.forename: Sundar P
authors.initials: SP
authors.lastname: Authimoolam
authors.affiliation: Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, Kentucky, 40506, USA.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Lakes
authors.affiliation: Department of Biomedical Engineering, College of Engineering, University of Kentucky, 522 Robotics Building, Lexington, Kentucky, 40506, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Puleo
authors.affiliation: Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, Kentucky, 40506, USA. dziubla@engr.uky.edu.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Dziubla
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008823:Micelles; D009077:Mucins / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D008823:Micelles; D009077:Mucins; D019809:Streptavidin
keywords: biomimetic; biotin-streptavidin; filomicelles; mucin; oral drug delivery