title: [Pathway-focused correlation study of genome-wide methylation status with visual memory].
abstract: OBJECTIVE To explore the biological processes and pathways associated with memory function which may be regulated by gene promoter methylation. METHODS The genome-wide promoter methylation statuses in 9 healthy individuals were analyzed with a Multiplex HG18 CpG Promoter chip. Genes with promoter methylation statuses strongly correlated with both immediate and delayed visual memory function were preceded for pathway and physical interactions analysis. RESULTS Sixty nine genes have been correlated with both immediate and delayed visual memory functions. Twenty two pathways, with a Q-value of < 0.05, were identified by the pathway and physical interactions analysis, which included energy metabolism, axon guidance, tyrosine kinase activity, anterograde synaptic vesicle transport, and leukocyte migration and differentiation. CONCLUSION Pathways related with memory function may be regulated by DNA methylation.
authors.affiliation: Psychiatric Laboratory, Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China. Email: xuntao26@hotmail.com.
authors.forename: Xiaochu
authors.initials: X
authors.lastname: Gu
authors.forename: Peiyan
authors.initials: P
authors.lastname: Ni
authors.forename: Bo
authors.initials: B
authors.lastname: Xiang
authors.forename: Liansheng
authors.initials: L
authors.lastname: Zhao
authors.forename: Jinxue
authors.initials: J
authors.lastname: Wei
authors.forename: Yingche
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D019175:DNA Methylation; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D011401:Promoter Regions, Genetic; D015398:Signal Transduction / Q000502:physiology*