title: The Value and Relevance of the T Cell Lymphoma Registries and International Collaborations: the Case of COMPLETE and the T-Cell Project.
abstract: Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies that portend a poor prognosis and have an undefined optimal therapeutic strategy. Data on best practices stem from prior studies that have generally included B cell lymphomas. However, the enhanced ability to diagnose PTCLs, the development of newer agents specific for PTCLs, and its increased incidence have called the scientific community to develop better strategies to combat these neoplasms. To that end, T cell lymphoma registries were developed in an attempt to answer relevant questions on the prognosis and management of PTCLs. The largest registries currently enrolling patients are the Comprehesive Oncology Measures for PeripheraL T-cEll Lymphoma TrEatment (COMPLETE) and the T-Cell Project. Despite the inherent limitations of these studies, valuable information are being collected to refine our management approaches and to aid in designing future clinical trials. This review illustrates the value of these registries and describes the critical questions that need to be answered.
authors.affiliation: Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Centro Oncologico Modenese, Via del Pozzo 71, 41124, Modena, MO, Italy. monica.bellei@unimore.it.
authors.forename: Monica
authors.initials: M
authors.lastname: Bellei
authors.affiliation: Section of Hematology and Oncology, Medical Director, Clinical Outpatient Cancer Center, The University of Chicago, 5841 South Maryland Ave MC2115, Chicago, IL, 60637, USA. cnabhan@medicine.bsd.uchicago.edu.
authors.forename: Chadi
authors.initials: C
authors.lastname: Nabhan
authors.affiliation: Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Centro Oncologico Modenese, Via del Pozzo 71, 41124, Modena, MO, Italy. emanuelaanna.pesce@unimore.it.
authors.forename: Emanuela Anna
authors.initials: EA
authors.lastname: Pesce
authors.affiliation: Interdisciplinary Laboratory of Applied Research in Medicine (DReAM), University of Salento at the Hospital "V. FAZZI", Piazza F. Muratore n.1, Palazzina Direzione Amministrativa, I Piano DReAM, 73100, Lecce, LE, Italy. luana.conte@unisalento.it.
authors.forename: Luana
authors.initials: L
authors.lastname: Conte
authors.affiliation: Division of Hematology/Oncology, University of Nebraska Medical Center|, Omaha, NE, 68198-7680, USA. jmvose@unmc.edu.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Vose
authors.affiliation: Yale Medical Oncology, Smilow Cancer Hospital at Yale-New Haven, South Frontage Road and Park Street, 7th Floor Multispecialty Care Center, New Haven, CT, 0651, USA. francine.foss@yale.edu.
authors.forename: Francine
authors.initials: F
authors.lastname: Foss
authors.affiliation: Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Centro Oncologico Modenese, Via del Pozzo 71, 41124, Modena, MO, Italy. massimo.federico@unimore.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Federico
mesh_terms: D003299:Cooperative Behavior; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral; D012042:Registries
keywords: COMPLETE; Peripheral T cell lymphomas; T cell lymphoma registries; T-Cell Project