title: Adipokinins in pregnancies at risk of preterm delivery.
abstract: OBJECTIVE
  To compare adipokinins between women experiencing preterm labor (PTL) and prior preterm deliveries (PTD).
  
  
  METHODS
  In this prospective observational cohort, 110 women with a singleton <35 weeks at increased risk of PTD were studied. Serum leptin, adiponectin, and resistin were obtained at three times (23-34 weeks, 35-36 weeks, at delivery) and analyzed via enzyme-linked immunosorbent assay. The adipokinins were compared across time and between PTL (n = 59) and prior PTD (n = 51) groups using generalized estimated equation models.
  
  
  RESULTS
  There were no differences in leptin, adiponectin, or resistin levels over the three times between the PTL and PTD groups. There was a trend toward higher leptin levels (p = 0.06 unadjusted analysis, p = 0.09 adjusted analysis) at 23-34 weeks. When stratified by body mass index (BMI), there were differences in leptin (p < 0.001 for BMI < 30; p = 0.77 for BMI ≥ 30) and adiponectin (p = 0.04 for BMI < 30; p = 0.09 for BMI ≥ 30), but not in resistin over the three times between the PTL and prior PTD groups.
  
  
  CONCLUSIONS
  There were no significant differences in adipokinins in women with PTL and a prior PTD. The trends toward higher leptin levels at 23-34 weeks in women with PTL may represent a compensatory response and require further evaluation in the study of treatments for PTL.
authors.affiliation: a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, University of Illinois at Chicago , Chicago , IL , USA .
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Kominiarek
authors.affiliation: b Division of Maternal-Fetal Medicine , Department of Obstetrics and Gynecology, Tulane University , New Orleans , LA , USA , and.
authors.forename: Cecilia T
authors.initials: CT
authors.lastname: Gambala
authors.affiliation: a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, University of Illinois at Chicago , Chicago , IL , USA .
authors.forename: Monique
authors.initials: M
authors.lastname: Sutherland
authors.affiliation: c College of Applied Health Sciences, Department of Kinesiology and Nutrition, University of Illinois at Chicago , Chicago , IL , USA.
authors.forename: Krista
authors.initials: K
authors.lastname: Varady
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D007752:Obstetric Labor, Premature / Q000097:blood* / Q000453:epidemiology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D047928:Premature Birth / Q000097:blood* / Q000453:epidemiology; D011446:Prospective Studies; D052243:Resistin / Q000097:blood*; D012306:Risk; D055815:Young Adult
chemical_list: D052242:Adiponectin; D020738:Leptin; D052243:Resistin
keywords: Adipokinins; obesity; pregnancy; preterm delivery