title: The developmental inter-relationships between activity, novelty preferences, and delay discounting in male and female rats.
abstract: Increased locomotion, novelty-seeking, and impulsivity are risk factors associated with substance use. In this study, the inter-relationships between activity, novelty preferences, and delay discounting, a measure of impulsivity, were examined across three stages: juvenile/early adolescence (postnatal Day [P] 15, 19, and 42 for activity, novelty, and impulsivity, respectively), adolescent/late adolescent (P28, 32, 73), and adult (P90, 94, 137) in male and female rats. Our estimates of impulsive choice, where animals were trained to criterion, revealed an age × sex interaction where early adolescent females had the lowest levels of impulsivity. The relationships of activity and novelty to impulsivity significantly changed across age within each sex. Early adolescent males with high activity, but low novelty preferences, were more impulsive; however, low activity and high novelty preferences were related to high impulsivity in adult males. Female activity gradually increased across age, but did not show a strong relationship with impulsivity. Novelty preferences are moderately related to impulsivity into adulthood in females. These data show that males and females have different developmental trajectories for these behaviors. Males show greater sensation-seeking (e.g., activity) and risky behavior (e.g., novelty preferences) earlier in life, whereas these behaviors emerge during adolescence in females.
authors.affiliation: Laboratory of Developmental Neuropharmacology, Belmont, MA.|Department of Psychiatry, McLean Hospital, Harvard Medical School, Mailstop 333, 115 Mill Street, Belmont, MA, 02478.
authors.forename: Jodi L
authors.initials: JL
authors.lastname: Lukkes
authors.affiliation: Laboratory of Developmental Neuropharmacology, Belmont, MA.
authors.forename: Britta S
authors.initials: BS
authors.lastname: Thompson
authors.affiliation: Laboratory of Developmental Neuropharmacology, Belmont, MA.|Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
authors.forename: Nadja
authors.initials: N
authors.lastname: Freund
authors.affiliation: Laboratory of Developmental Neuropharmacology, Belmont, MA.|Department of Psychiatry, McLean Hospital, Harvard Medical School, Mailstop 333, 115 Mill Street, Belmont, MA, 02478.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Andersen
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D065786:Delay Discounting / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D007175:Impulsive Behavior; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D012737:Sex Factors
keywords: delay discounting; development; impulsivity; novelty; rat; sex differences