title: The Use of Interferons in the Treatment of Cutaneous T-Cell Lymphoma.
abstract: Interferons are polypeptides that naturally occur in the human body as a part of the innate immune response. By harnessing these immunomodulatory functions, synthetic interferons have shown efficacy in combating various diseases including cutaneous T-cell lymphoma. This article closely examines the qualities of interferon alfa and interferon gamma and the evidence behind their use in the 2 most common types of cutaneous T-cell lymphomas, namely, mycosis fungoides and Sézary syndrome.
authors.affiliation: Department of Dermatology, Hospital of the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: Natalie.spaccarelli2@uphs.upenn.edu.
authors.forename: Natalie
authors.initials: N
authors.lastname: Spaccarelli
authors.affiliation: Department of Dermatology, Hospital of the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Alain H
authors.initials: AH
authors.lastname: Rook
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D016899:Interferon-beta / Q000627:therapeutic use; D007371:Interferon-gamma / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D009182:Mycosis Fungoides / Q000188:drug therapy* / Q000628:therapy; D011701:PUVA Therapy / Q000379:methods; D012176:Retinoids / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha; D012176:Retinoids; D016899:Interferon-beta; D007371:Interferon-gamma
keywords: Cutaneous T-cell lymphoma; Interferon alfa; Interferon gamma; Interferons; Mycosis fungoides; Sézary syndrome