title: Drosophila melanogaster Natural Variation Affects Growth Dynamics of Infecting Listeria monocytogenes.
abstract: We find that in a Listeria monocytogenes/Drosophila melanogaster infection model, L. monocytogenes grows according to logistic kinetics, which means we can measure both a maximal growth rate and growth plateau for the microbe. Genetic variation of the host affects both of the pathogen growth parameters, and they can vary independently. Because growth rates and ceilings both correlate with host survival, both properties could drive evolution of the host. We find that growth rates and ceilings are sensitive to the initial infectious dose in a host genotype-dependent manner, implying that experimental results differ as we change the original challenge dose within a single strain of host.
authors.affiliation: Department of Microbiology and Immunology, Stanford University, California 94305-5124.
authors.forename: Alejandra Guzmán
authors.initials: AG
authors.lastname: Hotson
authors.affiliation: Department of Microbiology and Immunology, Stanford University, California 94305-5124 dschneider@stanford.edu.
authors.forename: David S
authors.initials: DS
authors.lastname: Schneider
mesh_terms: D000818:Animals; D058491:Bacterial Load; D004198:Disease Susceptibility; D004331:Drosophila melanogaster / Q000382:microbiology* / Q000502:physiology*; D014644:Genetic Variation; D005838:Genotype; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D007109:Immunity; D008089:Listeria monocytogenes / Q000502:physiology*; D009154:Mutation
keywords: Host-variation; bacterial growth dynamics; genetics of immunity