title: Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct.
abstract: Most imprinted genes are concerned with embryonic development, especially placental development. Here, we identified a placenta-specific imprinted gene Qpct. Our results show that Qpct is widely expressed during early embryonic development and can be detected in the telecephalon, midbrain, and rhombencephalon at E9.5b-E11.5. Moreover, Qpct is strikingly expressed in the brain, lung and liver in E15.5. Expression signals for Qpct achieved a peak at E15.5 during placental development and were only detected in the labyrinth layer in E15.5 placenta. ChIP assay results suggest that the modification of histone H3K4me3 can result in maternal activating of Qpct.
authors.affiliation: School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150001, Heilongjiang, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150001, Heilongjiang, China.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: He
authors.affiliation: School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150001, Heilongjiang, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150001, Heilongjiang, China.
authors.forename: Fengwei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150001, Heilongjiang, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lv
authors.affiliation: School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150001, Heilongjiang, China.
authors.forename: Tiebo
authors.initials: T
authors.lastname: Zeng
authors.affiliation: School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150001, Heilongjiang, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Gu
authors.affiliation: School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150001, Heilongjiang, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
mesh_terms: D019881:Aminoacyltransferases / Q000235:genetics*; D000818:Animals; D047369:Chromatin Immunoprecipitation; D019175:DNA Methylation; D047108:Embryonic Development / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000196:embryology / Q000378:metabolism; D008168:Lung / Q000196:embryology / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009035:Mothers; D010920:Placenta / Q000378:metabolism*; D010929:Placentation / Q000235:genetics*; D011247:Pregnancy; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism; D013687:Telencephalon / Q000196:embryology / Q000378:metabolism
chemical_list: D006657:Histones; D019881:Aminoacyltransferases; C059280:glutaminyl-peptide cyclotransferase
keywords: H3K4me3; Qpct; expression patterns; imprinted gene; placenta