title: Budesonide-related adrenal insufficiency.
abstract: Iatrogenic adrenal insufficiency is a potential harmful side effect of treatment with corticosteroids. It manifests itself when an insufficient cortisol response to biological stress leads to an Addisonian crisis: a life-threatening situation. We describe a case of a patient who developed an Addisonian crisis after inappropriate discontinuation of budesonide (a topical steroid used in Crohn's disease) treatment. Iatrogenic adrenal insufficiency due to budesonide use has been rarely reported. Prescribers should be aware of the resulting risk for an Addisonian crisis.
authors.affiliation: Department of Internal Medicine, Spaarne Gasthuis, Hoofddorp, The Netherlands.
authors.forename: Alexander
authors.initials: A
authors.lastname: Arntzenius
authors.affiliation: Department of Internal Medicine, VU Medical Centre, Amsterdam, Noord Holland, The Netherlands.
authors.forename: Louise
authors.initials: L
authors.lastname: van Galen
mesh_terms: D000309:Adrenal Insufficiency / Q000139:chemically induced*; D019819:Budesonide / Q000008:administration & dosage / Q000009:adverse effects*; D003424:Crohn Disease / Q000188:drug therapy*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D028761:Withholding Treatment
chemical_list: D005938:Glucocorticoids; D019819:Budesonide