title: Detection of Cortical Microbleeds in Postmortem Brains of Patients with Lewy Body Dementia: A 7.0-Tesla Magnetic Resonance Imaging Study with Neuropathological Correlates.
abstract: BACKGROUND
  It is unclear whether associated cerebrovascular pathology contributes to the clinical spectrum of Lewy body dementia (LBD).
  
  
  CONCLUSIONS
  The present postmortem 7.0-tesla MRI study investigates the anatomical distribution of cortical microbleeds (CoMBs) in LBD brains with and without associated Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). CoMBs predominated in the frontal section of the LBD brains and were associated to severe white matter lesions. No differences were observed when LBD brains with and without AD and CAA were compared.
  
  
  CONCLUSIONS
  In LBD, there is a specific distribution of CoMBs that is different from that in other neurodegenerative diseases. The increase of frontal CoMBs is not due to the frequently associated AD and CAA features but due to the LBD itself.
authors.affiliation: INSERM U1171, Universitx00E9; de Lille 2, Lille, France.
authors.forename: Jacques L
authors.initials: JL
authors.lastname: De Reuck
authors.forename: Florent
authors.initials: F
authors.lastname: Auger
authors.forename: Nicolas
authors.initials: N
authors.lastname: Durieux
authors.forename: Charlotte
authors.initials: C
authors.lastname: Cordonnier
authors.forename: Vincent
authors.initials: V
authors.lastname: Deramecourt
authors.forename: Florence
authors.initials: F
authors.lastname: Lebert
authors.forename: Didier
authors.initials: D
authors.lastname: Leys
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.forename: Claude-Alain
authors.initials: CA
authors.lastname: Maurage
authors.forename: Regis
authors.initials: R
authors.lastname: Bordet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged