title: Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice.
abstract: FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malonic dialdehyde, catalase, Cu, Zn-superoxide dismutase, vascular endothelial growth factor were studied in both mice strains. The parameters of life span and tumor pathology were studied as well. Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas and died before the age of 1 year. Forty tree percent of long-lived wild type mice survived the age of 2 years and 19 %-800 days. The total tumor incidence in wild type mice was 34 %. The age-associated changes in the level of serum IGF-1, glucose and insulin started much earlier in transgene HER-2/neu mice as compared with wild type FVB/N mice. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis.
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Panchenko
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758.
authors.forename: Irina G
authors.initials: IG
authors.lastname: Popovich
authors.affiliation: St.Petersburg State Pediatric Medical University, 2, Litovskaya str., St. Petersburg, Russia, 194100.
authors.forename: Alexandr P
authors.initials: AP
authors.lastname: Trashkov
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Egormin
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758.
authors.forename: Maria N
authors.initials: MN
authors.lastname: Yurova
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758.
authors.forename: Margarita L
authors.initials: ML
authors.lastname: Tyndyk
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758.
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Gubareva
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758.
authors.forename: Ilia N
authors.initials: IN
authors.lastname: Artyukin
authors.affiliation: St.Petersburg State Pediatric Medical University, 2, Litovskaya str., St. Petersburg, Russia, 194100.
authors.forename: Andrey G
authors.initials: AG
authors.lastname: Vasiliev
authors.affiliation: St.Petersburg State Pediatric Medical University, 2, Litovskaya str., St. Petersburg, Russia, 194100.
authors.forename: Nikolai V
authors.initials: NV
authors.lastname: Khaitsev
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Zabezhinski
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758. aging@mail.ru.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D063646:Carcinogenesis; D005260:Female; D018734:Genes, erbB-2; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D015415:Biomarkers
keywords: Biomarkers of aging; FVB/N mice; HER-2/neu; Life span; Spontaneous carcinogenesis