title: [Prevalence of Types TEM, SHV and CTX-M βLES Among Pathogens of Chronic Pyelonephritis].
abstract: There is lately observed an increase in the resistance of the main pathogens of urologic infection to β-lactam antibiotics due to production of plasmid-induced β-lactamases. The aim of the study was to reveal types TEM, SHV and CTX-M plasmid β-lactamases among uropathogens. Out of 115 isolates, 30 (26.1%) strains produced β-lactamases. Genes blaTEM and bla CTX-Mwere the most frequent. Most of the isolates were resistant to ampicillin (73.3%), ciprofloxacin (46.7%), levofloxacin (43.3%), gentamicin (40%). The βLES-producing strains were susceptible to meropenem (96.7%), nitroxolin (83.3%), phosphomycin (70%), amikacin (70%). The presence of the resistance genes in the uropathogens was evident of a high rate of their distribution among them by the plasmids. Detection of the plasmid-induced β-lactamases is important for the optimal choice of the antibiotic for empirical therapy.
authors.forename: A V
authors.initials: AV
authors.lastname: Bilchenko
authors.forename: O I
authors.initials: OI
authors.lastname: Chub
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002908:Chronic Disease; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects / Q000235:genetics*; D005260:Female; D005798:Genes, Bacterial; D006090:Gram-Negative Bacteria / Q000201:enzymology / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010957:Plasmids / Q000235:genetics / Q000302:isolation & purification; D011704:Pyelonephritis / Q000382:microbiology*; D055815:Young Adult; D018440:beta-Lactam Resistance / Q000187:drug effects / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases