title: Burden of serious fungal infections in Mexico.
abstract: Serious fungal infections (SFIs) could be more frequent than are recognised. Estimates of the incidence and prevalence of SFIs are essential in order to identify public health problems. We estimated the rates of SFIs in Mexico, following a methodology similar to that used in prior studies. We obtained information about the general population and populations at risk. A systematic literature search was undertaken to identify epidemiological reports of SFIs in Mexico. When Mexican reports were unavailable, we based our estimates on international literature. The most prevalent SFIs in Mexico are recurrent vulvovaginal candidiasis (5999 per 100,000) followed by allergic bronchopulmonary aspergillosis (60 per 100,000), chronic pulmonary aspergillosis (15.9 per 100,000), fungal keratitis (10.4 per 100,000), invasive candidiasis (8.6 per 100,000) and SFIs in HIV (8.2 per 100,000); coccidioidomycosis (7.6 per 100,000), IA (4.56 per 100,000). These correspond to 2,749,159 people affected in any year (2.45% of the population), probably >10,000 deaths and 7000 blind eyes. SFIs affect immunocompromised and healthy populations. Most are associated with high morbidity and mortality rates. Validation of these estimates with epidemiological studies is required. The burdens indicate that an urgent need to improve medical skills, surveillance, diagnosis, and management of SFIs exists.
authors.affiliation: Infectious Diseases and Epidemiology Department, Hospital General Dr. Manuel Gea González, Mexico City, Mexico.
authors.forename: D E
authors.initials: DE
authors.lastname: Corzo-León
authors.affiliation: Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK.|The NIHR Respiratory Rare Diseases Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Armstrong-James
authors.affiliation: National Aspergillosis Centre, The University Hospital of South Manchester, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Denning
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000453:epidemiology / Q000382:microbiology; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology; D002181:Candidiasis, Vulvovaginal / Q000453:epidemiology / Q000382:microbiology; D003047:Coccidioidomycosis / Q000453:epidemiology / Q000382:microbiology; D017281:Cost of Illness; D003881:Dermatomycoses / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D008800:Mexico / Q000453:epidemiology; D009181:Mycoses / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D015995:Prevalence; D055732:Pulmonary Aspergillosis / Q000453:epidemiology / Q000382:microbiology; D055815:Young Adult
keywords: Epidemiology; Mexico; aspergillosis; burden; fungal infection