title: Signal Mechanisms of Vascular Remodeling in the Development of Pulmonary Arterial Hypertension.
abstract: Pulmonary artery hypertension (PAH) is a chronic progressive disease characterized by persistent elevation of pulmonary arterial vascular pressure. The disease severely limits the function of the right ventricle, causing organ failure and finally leading to death. Despite significant advances in pharmacological treatments, PAH remains an incurable disease with high morbidity and mortality. The histopathological change of PAH is featured by remodeling of the pulmonary vascular. Abnormal proliferation of pulmonary artery smooth muscle cells in peripheral vascular is 1 major pathological finding of pulmonary vascular remodeling. Current therapeutics available for PAH primarily aim at inhibiting the pulmonary vasoconstriction and resisting pulmonary vascular remodeling. To date, only some inhibitors targeting proliferative signaling pathways have been used to suppress the proliferation of pulmonary artery smooth muscle cells and reverse pulmonary vascular remodeling. However, because of serious side effects, their clinical use is limited, and more validation is needed before the inhibitors can be transferred into clinical use. This review will focus on signal mechanisms of vascular remodeling in the development of PAH and give an overview of recent advances in research on inhibitors targeting proliferative pathways.
authors.affiliation: *Department of Pharmacy, Zhu Jiang Hospital, Southern Medical University, Guangzhou, China; †Department of Biopharmaceutical, Yulin Normal University, Yulin, China; and ‡Department of Clinical Pharmacy, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou, China.
authors.forename: Ming-xing
authors.initials: MX
authors.lastname: Li
authors.forename: De-qi
authors.initials: DQ
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Qing-zhuang
authors.initials: QZ
authors.lastname: Chen
authors.forename: Yan-jiao
authors.initials: YJ
authors.lastname: Ma
authors.forename: Shan-shan
authors.initials: SS
authors.lastname: Yu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism* / Q000473:pathology*; D018836:Inflammation Mediators / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology; D011651:Pulmonary Artery / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology*; D066253:Vascular Remodeling / Q000502:physiology*
chemical_list: D018836:Inflammation Mediators