title: Facile synthesis of chitosan/ZnO bio-nanocomposite hydrogel beads as drug delivery systems.
abstract: ZnO nanoparticles were synthesized in situ during the formation of physically cross-linked chitosan hydrogel beads using sodium tripolyphosphate as the cross-linker. The aim of the study was to investigate whether these nanocomposite beads have the potential to be used in drug delivery applications. The formation of ZnO nanoparticles (ZnONPs) in the hydrogels was confirmed by X-ray diffraction and scanning electron microscopy studies. SEM micrographs revealed the formation of ZnONPs with size range of 10-25 nm within the hydrogel matrix. Furthermore, the swelling and drug release properties of the beads were studied. The prepared nanocomposite hydrogels showed a pH sensitive swelling behavior. The ZnO nanocomposite hydrogels have rather higher swelling ratio in different aqueous solutions in comparison with neat hydrogel. In vitro drug release test was carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system. A prolonged and more controlled drug releases were observed for ZnONPs containing chitosan beads, which increased by the increase in ZnONPs content.
authors.affiliation: Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran. Electronic address: yadollahi_mehdi@yahoo.com.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yadollahi
authors.affiliation: Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran.
authors.forename: Sana
authors.initials: S
authors.lastname: Farhoudian
authors.affiliation: Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran.
authors.forename: Soroush
authors.initials: S
authors.lastname: Barkhordari
authors.affiliation: Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran.
authors.forename: Iman
authors.initials: I
authors.lastname: Gholamali
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Farhadnejad
authors.affiliation: Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Motasadizadeh
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D008863:Microspheres; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D048271:Chitosan; D015034:Zinc Oxide
keywords: Chitosan hydrogel; Drug delivery; ZnO nanoparticle