title: Epigenetic regulation in acute kidney injury: new light in a dark area.
abstract: Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury (AKI). Mar et al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|Department of Cellular Biology and Anatomy, Medical College of Georgia at Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, Georgia, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
mesh_terms: D058186:Acute Kidney Injury / Q000235:genetics*; D000818:Animals; D044127:Epigenesis, Genetic; D007668:Kidney; D008070:Lipopolysaccharides; D008297:Male; D015427:Reperfusion Injury / Q000235:genetics*
chemical_list: D008070:Lipopolysaccharides