title: Low 25 (OH) vitamin D levels are associated with autoimmune thyroid disease in polycystic ovary syndrome.
abstract: Low 25(OH) vitamin D levels have been associated with several autoimmune diseases and recently with autoimmune thyroid disease (AITD). The aim of the study was to investigate the association of AITD with 25(OH) vitamin D levels in women with polycystic ovary syndrome (PCOS). Fifty women with PCOS were consecutively enrolled and underwent routine health checkups, which included measurements of 25(OH) vitamin D, anti-thyroid peroxidase (TPO-Ab), anti-thyreoglobulin (TG-Ab) antibodies, FT3, FT4, and TSH. Selecting 50 nmol/L as cut-off point, low 25(OH) vitamin D levels were detected in 23 of 50 patients (46 %). AITD was diagnosed when TPO-Ab levels exceeding 80 U/ml and/or TG-Ab levels exceeding 70 U/ml. AITD was detected in 12 of 50 patients (24 %). The levels of 25(OH) vitamin D were significantly lower in women with PCOS and AITD when compared with women with PCOS and without AITD (p = 0.02). In women with AITD no correlation was found between 25(OH) vitamin D and TG-Ab (r = 0.48; p = 0.16), TPO-Ab (r = 0.43; p = 0.21), TSH (r = 0.38; p = 0.27), FT3 (r = -0.40; p = 0.25) and FT4 levels (r = -0.54; p = 0.10). These findings suggest that low levels of 25(OH) vitamin D were significantly associated with AITD in women with PCOS.
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University of Naples, via S. Pansini 5, 80131, Naples, Italy. giovanna.muscogiuri@gmail.com.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Muscogiuri
authors.affiliation: Department of Obstetrics and Gynecology, IRCCS, Arcispedale S. Maria Nuova of Reggio Emilia, Reggio Emilia, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Palomba
authors.affiliation: SSD Odontoiatria AOU "S. Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Caggiano
authors.affiliation: Department of Sports Science and Wellness, "Parthenope" University Naples, Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Tafuri
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University of Naples, via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.affiliation: Department of Sports Science and Wellness, "Parthenope" University Naples, Naples, Italy.|Endocrinology and Diabetology, Fertility Techniques Structure, University Hospital "S. Giovanni di Dio e Ruggi d'Aragona", Largo Città d'Ippocrate, Salerno, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Orio
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000150:complications* / Q000276:immunology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D014284:Triiodothyronine; D014807:Vitamin D; D013972:Thyrotropin; D013954:Thyroglobulin; C104450:25-hydroxyvitamin D; D007453:Iodide Peroxidase; D013974:Thyroxine
keywords: Autoimmune thyroid disease; PCOS; Vitamin D