title: T-cell-based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition.
abstract: Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell-based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell-based strategies currently in clinical trials and put their applications, present and future, into perspective.
authors.affiliation: CHU Rennes, Service Hématologie Clinique, Rennes, France. INSERM U917, Rennes, France.
authors.forename: Roch
authors.initials: R
authors.lastname: Houot
authors.affiliation: Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Lucile Packard Children's Hospital and Stanford University, Stanford, California.
authors.forename: Liora Michal
authors.initials: LM
authors.lastname: Schultz
authors.affiliation: Gustave Roussy Cancer Center, Drug Development Department, INSERM U1015, Villejuif, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Marabelle
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University, Stanford, California. Kohrt@stanford.edu.
authors.forename: Holbrook
authors.initials: H
authors.lastname: Kohrt
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D011993:Recombinant Fusion Proteins