title: Compilation of a standardised international folate database for EPIC.
abstract: This paper describes the methodology applied for compiling an "international end-user" folate database. This work benefits from the unique dataset offered by the European Prospective Investigation into Cancer and Nutrition (EPIC) (N=520,000 subjects in 23 centres). Compilation was done in four steps: (1) identify folate-free foods then find folate values for (2) folate-rich foods common across EPIC countries, (3) the remaining "common" foods, and (4) "country-specific" foods. Compiled folate values were concurrently standardised in terms of unit, mode of expression and chemical analysis, using information in national food composition tables (FCT). 43-70% total folate values were documented as measured by microbiological assay. Foods reported in EPIC were either matched directly to FCT foods, treated as recipes or weighted averages. This work has produced the first standardised folate dataset in Europe, which was used to calculate folate intakes in EPIC; a prerequisite to study the relation between folate intake and diseases.
authors.affiliation: Nutrition and Metabolism Section, Dietary Exposure Assessment Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France. Electronic address: nicolasg@iarc.fr.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Nicolas
authors.affiliation: Department of Food Science, Uppsala BioCenter, Swedish University of Agricultural Sciences, SLU, P.O. Box 7051, SE-750 07 Uppsala, Sweden.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Witthöft
authors.affiliation: Nutrition and Metabolism Section, Dietary Exposure Assessment Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Vignat
authors.affiliation: Nutrition and Metabolism Section, Dietary Exposure Assessment Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France.
authors.forename: Viktoria
authors.initials: V
authors.lastname: Knaze
authors.affiliation: Nutrition and Metabolism Section, Dietary Exposure Assessment Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France.
authors.forename: Inge
authors.initials: I
authors.lastname: Huybrechts
authors.affiliation: Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, United Kingdom.
authors.forename: Mark
authors.initials: M
authors.lastname: Roe
authors.affiliation: Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Finglas
authors.affiliation: Nutrition and Metabolism Section, Dietary Exposure Assessment Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
mesh_terms: D016208:Databases, Factual / Q000592:standards*; D004032:Diet; D005060:Europe; D005492:Folic Acid / Q000008:administration & dosage; D005502:Food; D006801:Humans; D009369:Neoplasms; D015596:Nutrition Assessment; D009747:Nutritional Physiological Phenomena; D011446:Prospective Studies; D012015:Reference Standards
chemical_list: D005492:Folic Acid
keywords: ENDB; EuroFIR; Folate; Nutrient database; Standardization