title: Synthesis and antibacterial activity of novel 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives.
abstract: BACKGROUND
  The intensely increasing multi-drug resistant microbial infections have encouraged the search for new antimicrobial agents. Hydrazone derivatives are known to exhibit a wide variety of biological activities including anti-microbial. In heterocyclic moiety, imidazo[1,2-a]pyrimidines are the subject of immense interest for their antimicrobial activity and also for their analgesic, antipyretic and anti-inflammatory properties.
  
  
  RESULTS
  Condensation of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide7with aromatic aldehydesa-kin ethanol at reflux led to the generation of hydrazone derivatives8a-kin 80-92% yield. The synthesis of carbohydrazide7was accomplished in six steps from commercially available 2-amino pyrimidine. The structures of the synthesized compounds were confirmed by1H,13C NMR, Mass and IR spectral data. All the synthesized hydrazone derivatives8a-kwere tested in vitro for their antibacterial activity. Compounds8d,8eand8fexhibited excellent antibacterial activity with zone of inhibition 30-33 mm againstE. coli(Gram negative bacteria) andS. aureus(Gram positive bacteria). These compounds also exhibited excellent antibacterial activity with zone of inhibition 22-25 mm againstP. aeruginosa(Gram negative bacteria) andS. pyogenes(Gram positive bacteria).
  
  
  CONCLUSIONS
  Synthesized and recorded antibacterial activity of some new 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine-hydrazone derivatives.Graphical abstract:Synthesis of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives.
authors.affiliation: Geethanjali College of Engineering and Technology, Keesara, Rangareddy, 501301 Telangana India ; Mahatma Gandhi Institute of Technology, Gandipet, Hyderabad, 500 075 Telangana India.
authors.forename: Shashikala
authors.initials: S
authors.lastname: Kethireddy
authors.affiliation: Mahatma Gandhi Institute of Technology, Gandipet, Hyderabad, 500 075 Telangana India.
authors.forename: Laxminarayana
authors.initials: L
authors.lastname: Eppakayala
authors.affiliation: Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, 500085 Telangana India.
authors.forename: Thirumala Chary
authors.initials: TC
authors.lastname: Maringanti
keywords: 2-Amino pyrimidine; Antibacterial activity; Imidazo[1,2-a]pyrimidine-hydrazones; Norfloxacin