title: To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe(III) -Porphyrin Center.
abstract: A positive myocardial inotropic effect achieved using HNO/NO(-) , compared with NO⋅, triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a Fe(III) -porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO)2 }(9) DNIC [Fe(μ-(Me) Pyr)(NO)2 ]2 was discovered as a potent nitroxyl donor for nitroxylation of Fe(III) -heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies.
authors.affiliation: Department of Chemistry, Chung Yuan Christian University No. 200, Chung Pei Rd. Taoyuan, 32023 (Taiwan).
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Tseng
authors.affiliation: School of Medical Applied Chemistry, Chung Shan Medical University, No. 110, Section 1, Jianguo North Rd. Taichung, 40201 (Taiwan).
authors.forename: Chien-Hong
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Chung Yuan Christian University No. 200, Chung Pei Rd. Taoyuan, 32023 (Taiwan).
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Chung Yuan Christian University No. 200, Chung Pei Rd. Taoyuan, 32023 (Taiwan).
authors.forename: Bing-Han
authors.initials: BH
authors.lastname: Li
authors.affiliation: Department of Chemistry, Chung Yuan Christian University No. 200, Chung Pei Rd. Taoyuan, 32023 (Taiwan).
authors.forename: Yu-Huan
authors.initials: YH
authors.lastname: Lu
authors.affiliation: Department of Chemistry, Chung Yuan Christian University No. 200, Chung Pei Rd. Taoyuan, 32023 (Taiwan).
authors.forename: Chia-Her
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Chung Yuan Christian University No. 200, Chung Pei Rd. Taoyuan, 32023 (Taiwan).
authors.forename: Hsin-Tsung
authors.initials: HT
authors.lastname: Chen
authors.affiliation: SLAC National Accelerator Laboratory 2575 Sand Hill Rd. Menlo Park, CA 94025 (USA).
authors.forename: Tsu-Chien
authors.initials: TC
authors.lastname: Weng
authors.affiliation: SLAC National Accelerator Laboratory 2575 Sand Hill Rd. Menlo Park, CA 94025 (USA).
authors.forename: Dimosthenes
authors.initials: D
authors.lastname: Sokaras
authors.affiliation: National Synchrotron Radiation Research Center No. 101, Xin'an Rd., Hsinchu, 30076 (Taiwan).
authors.forename: Huang-Yeh
authors.initials: HY
authors.lastname: Chen
authors.affiliation: National Synchrotron Radiation Research Center No. 101, Xin'an Rd., Hsinchu, 30076 (Taiwan).|Department of Physics, National Tsing Hua University No. 101, Section 2, Guangfu Rd., Hsinchu, 30013 (Taiwan).
authors.forename: Yun-Liang
authors.initials: YL
authors.lastname: Soo
authors.affiliation: Department of Chemistry, Chung Yuan Christian University No. 200, Chung Pei Rd. Taoyuan, 32023 (Taiwan). TTLu@cycu.edu.tw.
authors.forename: Tsai-Te
authors.initials: TT
authors.lastname: Lu
keywords: X-ray emission spectroscopy; bioinorganic chemistry; nitrosyl complexes; nitroxyl