title: Targretin Improves Cognitive and Biological Markers in a Patient with Alzheimer's Disease.
abstract: We present the effects of Targretin® (bexarotene) on cognition and biomarkers in a patient with mild Alzheimer's disease (AD). Targretin® is a Retinoic X Receptor (RXR) agonist shown to improve synaptic and cognitive functions in animal models of AD by increasing neuronal cholesterol efflux. After 6 months of treatment with Targretin® 300 mg/day, memory improved by about 40% and the tau protein in the cerebrospinal fluid decreased by about 20% . No significant side effects were noticed. This observation in a single patient indicates that Targretin® may improve memory performance and biological markers at an early stage of AD.
authors.affiliation: Université catholique de Louvain, Brussels, Belgium.|Institute of Neuroscience, Brussels, Belgium.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Pierrot
authors.affiliation: Université catholique de Louvain, Brussels, Belgium.|Institute of Neuroscience, Brussels, Belgium.|Cliniques universitaires Saint Luc, Nuclear Medicine department, Brussels, Belgium.
authors.forename: Renaud
authors.initials: R
authors.lastname: Lhommel
authors.affiliation: Université catholique de Louvain, Brussels, Belgium.|Institute of Neuroscience, Brussels, Belgium.
authors.forename: Lisa
authors.initials: L
authors.lastname: Quenon
authors.affiliation: Université catholique de Louvain, Brussels, Belgium.|Cliniques universitaires Saint Luc, Neurology department, Brussels, Belgium.
authors.forename: Bernard
authors.initials: B
authors.lastname: Hanseeuw
authors.affiliation: Université catholique de Louvain, Brussels, Belgium.|Institute of Neuroscience, Brussels, Belgium.
authors.forename: Laurence
authors.initials: L
authors.lastname: Dricot
authors.affiliation: Université catholique de Louvain, Brussels, Belgium.|Institute of Neuroscience, Brussels, Belgium.
authors.forename: Christian
authors.initials: C
authors.lastname: Sindic
authors.affiliation: Université catholique de Louvain, Brussels, Belgium.|Institute of Neuroscience, Brussels, Belgium.|Cliniques universitaires Saint Luc, Neurology department, Brussels, Belgium.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Maloteaux
authors.affiliation: Université catholique de Louvain, Brussels, Belgium.|Institute of Neuroscience, Brussels, Belgium.
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Octavea
authors.affiliation: Université catholique de Louvain, Brussels, Belgium.|Institute of Neuroscience, Brussels, Belgium.|Cliniques universitaires Saint Luc, Neurology department, Brussels, Belgium.
authors.forename: Adrian
authors.initials: A
authors.lastname: Ivanoiu
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000150:complications* / Q000188:drug therapy; D058227:Amyloidogenic Proteins / Q000134:cerebrospinal fluid; D000077610:Bexarotene; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects / Q000941:ethics; D009483:Neuropsychological Tests; D018168:Receptors, Retinoic Acid / Q000819:agonists; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use*; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D058227:Amyloidogenic Proteins; D015415:Biomarkers; D018168:Receptors, Retinoic Acid; D013764:Tetrahydronaphthalenes; D016875:tau Proteins; D000077610:Bexarotene
keywords: Amyloid-β and tau markers; Targretin/bexarotene; cholesterol; cognition