title: Occurrence of spontaneous and audiogenic seizures following global brain ischaemia due to cardiac arrest.
abstract: Transient cardiac arrest due to cardiac vessel bundle occlusion was used to produce a rat model of spontaneous and audiogenic seizures. Among the rats, spontaneous seizures were present in 64%, and audiogenic seizures could be evoked in 86%, during two weeks of survival after cardiac arrest, by exposure to a loud sound produced by rattling keys, beginning one day after the post-ischaemic injury. Data from literature suggested a key role for GABA-ergic system widespread dysfunction especially in the hippocampus in post-cardiac arrest onset of audiogenic seizures. Reduced GABA inhibition in the hippocampus seems responsible for audiogenic seizures following cardiac arrest. In summary it may be considered that the occurrence of audiogenic seizures following cardiac arrest is determined not only by a neuronal loss, especially in the hippocampus, but also by a condition of synapse modification by a regenerative phenomenon. Data from our study clearly indicate that global brain ischaemia due to cardiac arrest may induce the susceptibility to spontaneous and audiogenic seizures, but this effect is transient.
authors.forename: Marzena
authors.initials: M
authors.lastname: Ułamek-Kozioł
authors.forename: Janusz
authors.initials: J
authors.lastname: Kocki
authors.forename: Anna
authors.initials: A
authors.lastname: Bogucka-Kocka
authors.forename: Sławomir
authors.initials: S
authors.lastname: Januszewski
authors.forename: Stanisław J
authors.initials: SJ
authors.lastname: Czuczwar
authors.affiliation: Prof. Ryszard Pluta, MD, PhD, Laboratory of Ischaemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego St., 02-106 Warsaw, Poland, phone: +48 22 608 65 40 or 608 64 69, fax: +48 22 668 55 32, e-mail: pluta@imdik.pan.pl.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Pluta
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications*; D004195:Disease Models, Animal; D020195:Epilepsy, Reflex / Q000209:etiology*; D005260:Female; D006323:Heart Arrest / Q000150:complications*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000209:etiology*