title: Aging and Vision.
abstract: Aging involves defined genetic, biochemical and cellular pathways that regulate lifespan. These pathways are called longevity pathways and they have relevance for many age-related diseases. In the eye, longevity pathways are involved in the major blinding diseases, cataract, glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy. Pharmaceutical targeting of longevity pathways can extend healthy lifespan in laboratory model systems. This offers the possibility of therapeutic interventions to also delay onset or slow the progression of age-related eye diseases. I suggest that retinal degeneration may be viewed as accelerated aging of photoreceptors and that interventions extending healthy lifespan may also slow the pace of photoreceptor loss.
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, 10 Koret Way, 94143, San Francisco, CA, USA. marcel.alavi@gmail.com.
authors.forename: Marcel V
authors.initials: MV
authors.lastname: Alavi
mesh_terms: D000375:Aging; D000818:Animals; D002386:Cataract / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D008268:Macular Degeneration / Q000503:physiopathology*; D012160:Retina / Q000503:physiopathology; D013997:Time Factors; D014785:Vision, Ocular / Q000502:physiology*
keywords: Age-related macular degeneration (AMD); Aging; Cataract; Glaucoma; Insulin Diabetic retinopathy; Lens; Longevity pathways; Retina; Retinal ganglion cells; Vision impairments