title: Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians.
abstract: OBJECTIVE
  To investigate the association of polymorphisms located near the FOXC2 gene with the risk of varicose veins in ethnic Russians.
  
  
  METHODS
  Allele, genotype, and haplotype frequencies were determined in the sample of 474 patients with primary varicose veins and in the control group of 478 individuals without a history of chronic venous disease.
  
  
  RESULTS
  Polymorphisms rs7189489, rs4633732, and rs1035550 showed the association with the increased risk of varicose veins, but none of the observed associations remained significant after correction for multiple testing. Haplotype analysis revealed the association of haplotype rs7189489 C-rs4633732 T-rs34221221 C-rs1035550 C-rs34152738 T-rs12711457 G with the increased risk of varicose veins (OR = 2.67, P = 0.01).
  
  
  CONCLUSIONS
  Our results provide evidence that the studied polymorphisms do not play a major role in susceptibility to varicose veins development in the Russian population.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia weiner.alexserg@gmail.com.
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Shadrina
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: Mariya A
authors.initials: MA
authors.lastname: Smetanina
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia.
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Sokolova
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: Kseniya S
authors.initials: KS
authors.lastname: Sevost'ianova
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: Andrey I
authors.initials: AI
authors.lastname: Shevela
authors.affiliation: Private Surgery Center "Medalp", Saint Petersburg, Russia.
authors.forename: Marina Y
authors.initials: MY
authors.lastname: Demekhova
authors.affiliation: Private Surgery Center "Medalp", Saint Petersburg, Russia.
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Shonov
authors.affiliation: Private Surgery Center "Medalp", Saint Petersburg, Russia.
authors.forename: Evgenii A
authors.initials: EA
authors.lastname: Ilyukhin
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia.
authors.forename: Elena N
authors.initials: EN
authors.lastname: Voronina
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: Igor A
authors.initials: IA
authors.lastname: Zolotukhin
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Kirienko
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia Kazan Federal University, Kazan, Republic of Tatarstan, Russia.
authors.forename: Maxim L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012426:Russia / Q000208:ethnology; D014648:Varicose Veins / Q000208:ethnology / Q000235:genetics*
chemical_list: D051858:Forkhead Transcription Factors; C082078:mesenchyme fork head 1 protein
keywords: FOXC2; Russians; Varicose veins; association; single nucleotide polymorphism