title: Early bone response to machined, sandblasting acid etching (SLA) and novel surface-functionalization (SLAffinity) titanium implants: characterization, biomechanical analysis and histological evaluation in pigs.
abstract: The purpose of the present study was to examine early tissue response and osseointegration in the animal model. The surface morphologies of SLAffinity were characterized using scanning electron microscopy and atomic force microscopy. The microstructures were examined by X-ray diffraction, and hardness was measured by nanoindentation. Moreover, the safety and toxicity properties were evaluated using computer-aided programs and cell cytotoxicity assays. In the animal model, implants were installed in the mandibular canine-premolar area of 12 miniature pigs. Each pig received three implants: machine, sandblasted, large grit, acid-etched, and SLAffinity-treated implants. The results showed that surface treatment did affect bone-to-implant contact (BIC) significantly. At 3 weeks, the SLAffinity-treated implants were found to present significantly higher BIC values than the untreated implants. The SLAffinity treatments enhanced osseointegration significantly, especially at early stages of bone tissue healing. As described above, the results of the present study demonstrate that the SLAffinity treatment is a reliable surface modification method.
authors.affiliation: Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.|Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Hsi-Jen
authors.initials: HJ
authors.lastname: Chiang
authors.affiliation: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.|School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Heng-Jui
authors.initials: HJ
authors.lastname: Hsu
authors.affiliation: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.|School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Peng
authors.affiliation: School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.|Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan.
authors.forename: Ching-Zong
authors.initials: CZ
authors.lastname: Wu
authors.affiliation: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.|School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.|Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei 110, Taiwan.|Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, Taipei 235, Taiwan.
authors.forename: Keng-Liang
authors.initials: KL
authors.lastname: Ou
authors.affiliation: Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.|Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.|Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Han-Yi
authors.initials: HY
authors.lastname: Cheng
authors.affiliation: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.|College of Dentistry, University of Tennessee Health Sciences Center, 875 Union Avenue Memphis, TN 38103, USA.|Department of Restorative Dentistry Director of Laser Dentistry, 875 Union Avenue Memphis, TN 38103, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Walinski
authors.affiliation: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.|Department of Prosthodontic, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia.
authors.forename: Erwan
authors.initials: E
authors.lastname: Sugiatno
mesh_terms: D000818:Animals; D000069343:Bone-Implant Interface; D004285:Dogs; D020007:Implants, Experimental; D008334:Mandible / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D051379:Mice; D041681:NIH 3T3 Cells; D013499:Surface Properties; D013552:Swine; D013556:Swine, Miniature; D014025:Titanium
chemical_list: D014025:Titanium
keywords: dental implant; early tissue response; nano/microporous surface treatment; osseointegration