title: Effervescence and graphitized multi-walled carbon nanotubes assisted microextraction for natural antioxidants by ultra high performance liquid chromatography with electrochemical detection and quadrupole time-of-flight tandem mass spectrometry.
abstract: In this article, effervescence and graphitized multi-walled carbon nanotubes assisted microextraction was first developed for the extraction of antioxidants in hawthorn samples. The use of an effervescent tablet composed of sodium dihydrogen phosphate, sodium carbonate and micro-scale carboxyl graphitized multi-walled carbon nanotubes (extraction sorbent) was the core of the method. In this study, ultra high performance liquid chromatography coupled with electrochemical detection and quadrupole time-of-flight tandem mass spectrometry was performed for qualitative and quantitative analyses of target analytes in hawthorn foodstuffs. Several experimental factors, such as amount of effervescent salts, the sorbent, elution time and elution solvent, were systematically assessed. Under the optimized conditions, a good linearity with R values better than 0.9980 was obtained. The detection limits estimated at a signal-to-noise ratio of 3:1 were ranging from 0.01 to 0.18ng/mL. These results suggested that the proposed method could be an alternative and promising sample preparation tool in future food analysis.
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Shu-Ling
authors.initials: SL
authors.lastname: Wang
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Pang
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China. Electronic address: caojun91@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Cao
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Xu
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Qiong-Yao
authors.initials: QY
authors.lastname: Zhu
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Qian-Yun
authors.initials: QY
authors.lastname: Zhang
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Li-Qing
authors.initials: LQ
authors.lastname: Peng
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D027825:Crataegus / Q000737:chemistry*; D005504:Food Analysis; D057230:Limit of Detection; D037742:Nanotubes, Carbon; D010636:Phenols / Q000032:analysis*; D059629:Signal-To-Noise Ratio; D052617:Solid Phase Microextraction / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D000975:Antioxidants; D037742:Nanotubes, Carbon; D010636:Phenols
keywords: Antioxidants; Effervescence assisted microextraction; Graphitized multi-walled carbon nanotubes; Hawthorn; Quadrupole time-of-flight tandem mass spectrometry; Ultra high performance liquid chromatography with electrochemical detection