title: Instantaneous Click Chemistry by a Copper-Containing Polymeric-Membrane-Installed Microflow Catalytic Reactor.
abstract: The copper(I)-catalyzed Huisgen cycloaddition (azide-alkyne cycloaddition) is an important reaction in click chemistry that ideally proceeds instantaneously. An instantaneous Huisgen cycloaddition has been developed that uses a novel catalytic dinuclear copper complex-containing polymeric membrane-installed microflow device. A polymeric membranous copper catalyst was prepared from poly(4-vinylpyridine), copper(II) sulfate, sodium chloride, and sodium ascorbate at the interface of two laminar flows inside microchannels. Elucidation of the structure by XANES, EXAFS, and elemental analysis, as well as second-order Møller-Plesset perturbation theory (MP2) calculations and density functional theory (DFT) calculations assigned the local structure near Cu as a μ-chloro dinuclear Cu(I) complex. The microflow device promotes the instantaneous click reaction of a variety of alkynes and organic azides to afford the corresponding triazoles in quantitative yield.
authors.affiliation: RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-467-1423. ymayamada@riken.jp.
authors.forename: Yoichi M A
authors.initials: YM
authors.lastname: Yamada
authors.affiliation: RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-467-1423.
authors.forename: Aya
authors.initials: A
authors.lastname: Ohno
authors.affiliation: RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-467-1423.
authors.forename: Takuma
authors.initials: T
authors.lastname: Sato
authors.affiliation: RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-467-1423. uo@ims.ac.jp.|Institute for Molecular Science (IMS), Myodaiji, Okazaki, Aichi 444-8787 (Japan). uo@ims.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Uozumi
keywords: click chemistry; copper; cycloaddition; microreactors; polymeric membranes