title: [METABOLIC INTOXICATION IN THERMIC TRAUMA].
abstract: In 76 injured persons with deep and superficial burns, having area from 3 to 65% of the total body surface and ageing 5-16 yrs old, there was investigated the impact of early surgical treatment on the metabolic intoxication severity in accordance to content of the oxidatively modified proteins carbonyl groups in the blood serum, and of a ceruloplasmin, what was considered as integral express-index of the organism antioxidant system state. Changes of these indices in ambustial disease of middle severity have witnessed a sufficiently compensated reaction of organism: of severe and extremely severe one--there were noted a deficiency of the organism antioxidant defense; and in stages of toxemia and septicotoxemia--attrition of the organism oxidant reserves and danger of the septic complications occurrence. Conduction of early surgical intervention have guaranteed maintenance of a ceruloplasmin content in stages of toxemia and septicotoxemia on the level of healthy persons, relief of the ambustial disease course, absence of critical metabolic intoxication and carbonyl stress, reduction of the septic complications rate in 1.5 times.
authors.forename: O M
authors.initials: OM
authors.lastname: Kovalenko
mesh_terms: D000293:Adolescent; D002056:Burns / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D002570:Ceruloplasmin / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D062109:Dermatologic Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D050050:Protein Carbonylation; D012720:Severity of Illness Index; D012867:Skin / Q000378:metabolism / Q000473:pathology; D016038:Skin Transplantation; D017768:Skin, Artificial; D017695:Soft Tissue Injuries / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D014115:Toxemia / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D014182:Transplantation, Autologous
chemical_list: D002570:Ceruloplasmin