title: Italian guidelines for the management and treatment of neonatal cholestasis.
abstract: Hyperbilirubinemia is a frequent condition affecting newborns during the first two weeks of life and when it lasts more than 14 days it is defined as prolonged jaundice. This condition requires differential diagnosis between the usually benign unconjugated hyperbilirubinemia and the pathological conjugated hyperbilirubinemia, that is mainly due to neonatal cholestasis. It is important that the diagnosis of neonatal cholestasis be well-timed to optimize its management, prevent worsening of the patient's outcome, and to avoid premature, painful, expensive, and useless tests. Unfortunately, this does not always occur and, therefore, the Task Force on Hyperbilirubinemia of the Italian Society of Neonatology presents these shared Italian guidelines for the management and treatment of neonatal cholestasis whose overall aim is to provide a useful tool for its assessment for neonatologists and family pediatricians.
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health, Careggi University Hospital of Florence, Largo Brambilla 3, Florence, 50141, Italy. cdani@unifi.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Dani
authors.affiliation: Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy. simone.pratesi@unifi.it.
authors.forename: Simone
authors.initials: S
authors.lastname: Pratesi
authors.affiliation: Division of Neonatology, Section of Pediatrics Department of Translational Medical Sciences, Federico II University of Naples, Naples, Italy. raimondi@unina.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Raimondi
authors.affiliation: Division of Neonatology, Department of Pediatrics, Catholic University of Sacred Heart, Rome, Italy. cromagnoli@rm.unicatt.it.
authors.forename: Costantino
authors.initials: C
authors.lastname: Romagnoli
mesh_terms: D002779:Cholestasis / Q000175:diagnosis* / Q000628:therapy*; D019468:Disease Management; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D017410:Practice Guidelines as Topic