title: Linezolid Induced Adverse Drug Reactions - An Update.
abstract: Treatment regimen recommended for resistant tuberculosis consists of various drugs and these drugs are prescribed for at least 12-15 months. Such a long duration therapy and high dose of antibiotics result in adverse drug reactions (ADRs). ADRs may lead to various complications in disease management like replacement of drugs, dose increment, therapy withdrawal, etc. Linezolid is one of those drugs, practiced as an anti-mycobacterial agent and it is an important member of drug regimen for MDR and XDR tuberculosis. Linezolid is a broad spectrum antibiotic known for its unique mechanism of inhibition of resistant pathogenic strains. However, it causes serious adverse effects like thrombocytopenia, optic neuropathy, peripheral neuropathy, lactic acidosis, etc. Literature suggests that Linezolid can cause severe ADRs which affect patient compliance and hinder in therapy to a larger extent. Recent studies confirm the possibility of ADRs to be predicted with genetic make-up of individuals. To effectively deliver the available treatment regimen and ensure patient compliance, it is important to manage ADRs more efficiently. The role of pharmacogenomics in reducing adverse drug effects has been recently explored. In the present review, we discussed about Linezolid induced adverse drug reactions, mechanisms and genetic associations.
authors.affiliation: Analytical Division, Institute of Pesticide Formulation Technology, Sector- 20, Udyog Vihar, Gurgaon, Haryana- 122016 India. kishork@outlook.com.
authors.forename: Kamal
authors.initials: K
authors.lastname: Kishor
authors.forename: Neha
authors.initials: N
authors.lastname: Dhasmana
authors.forename: Shashank Shivaji
authors.initials: SS
authors.lastname: Kamble
authors.forename: Roshan Kumar
authors.initials: RK
authors.lastname: Sahu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics*; D000995:Antitubercular Agents / Q000009:adverse effects / Q000737:chemistry; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D000069349:Linezolid / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics*; D013921:Thrombocytopenia / Q000139:chemically induced / Q000175:diagnosis
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D000069349:Linezolid