title: Cross-dehydrogenative coupling of α-C(sp(3))-H of ethers/alkanes with C(sp(2))-H of heteroarenes under metal-free conditions.
abstract: Here we have developed an effective metal-free dehydrogenative coupling method wherein α-oxyalkyl and alkyl radicals were generated from various ethers and alkanes to undergo coupling with a variety of electron-deficient heteroarenes such as un/substituted iso-quinolones, quinolines, pyridines, pyrazines and pyrimidines. The persulfate-acetone-water system was optimized for the dehydrogenative coupling with cyclic ethers which gave moderate to excellent yields of α-oxyalkyl containing heteroarenes. We have also optimized the conditions for coupling with cyclic alkanes and alicyclic ethers and demonstrated by conducting the reactions with a variety of electron-deficient heteroarenes. Further, the present method is also applicable to electron deficient arenes like naphthoquinones and moreover, it didn't require any external acid.
authors.affiliation: Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India. ppsingh@iiim.ac.in.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Ambala
authors.forename: Thanusha
authors.initials: T
authors.lastname: Thatikonda
authors.forename: Shweta
authors.initials: S
authors.lastname: Sharma
authors.forename: Gurunadham
authors.initials: G
authors.lastname: Munagala
authors.forename: Kushalava Reddy
authors.initials: KR
authors.lastname: Yempalla
authors.forename: Ram A
authors.initials: RA
authors.lastname: Vishwakarma
authors.forename: Parvinder Pal
authors.initials: PP
authors.lastname: Singh