title: Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.
abstract: F-box proteins are substrate receptors of the SCF (SKP1-Cullin 1-F-box protein) E3 ubiquitin ligase that play important roles in a number of physiological processes and activities. Through their ability to assemble distinct E3 ubiquitin ligases and target key regulators of cellular activities for ubiquitylation and degradation, this versatile group of proteins is able to regulate the abundance of cellular proteins whose deregulated expression or activity contributes to disease. In this review, we describe the important roles of select F-box proteins in regulating cellular activities, the perturbation of which contributes to the initiation and progression of a number of human malignancies.
authors.affiliation: Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Jinho
authors.initials: J
authors.lastname: Heo
authors.affiliation: Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
authors.forename: Rebeka
authors.initials: R
authors.lastname: Eki
authors.affiliation: Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA; Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA. Electronic address: ta8e@virginia.edu.
authors.forename: Tarek
authors.initials: T
authors.lastname: Abbas
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D044783:F-Box Proteins / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D042822:Genomic Instability; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D020543:Proteome / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D044783:F-Box Proteins; D015513:Oncogene Proteins; D020543:Proteome; D025521:Tumor Suppressor Proteins; D014452:Ubiquitins
keywords: Cancer; E3 ubiquitin ligases; F-box; SCF; Ubiquitin