title: Thermo-induced modifications and selective accumulation of glucose-conjugated magnetic nanoparticles in vivo in rats - increasing the effectiveness of magnetic-assisted therapy - pilot study.
abstract: Ferro-Magnetic nanoparticles (Fe-MNP) have gained a lot of attention in biomedical and industrial applications due to their biocompatibility, ease of surface modification and paramagnetic properties. The basic idea of our study is whether it is possible to use glucose-conjugate Fe-MNP (Glc-Fe-MNP) for targeting and more accurate focusing in order to increase the effect of high-frequency electromagnetic fields induced hyperthermia in solid tumors. Tumors demonstrate high metabolic activity for glucose in comparison with other somatic cells.Increasing of accumulation of glucose conjugated (Glc)-Fe-MNP on tumor site and precision of radio frequency electro-magnetic field (RF-EMF) energy absorption in solid tumors, precede RF-EMF induced hyperthermia. Rat model for monitoring the early development of breast cancer. Twenty female Wistar rats (MU-line-6171) were divided into two groups of 10 rats that were either treated with N-methyl-N-nitrosourea to induce breast cancer and 10 with carrageenan to induce inflammation (control). Glc-Fe-MNP can offer a solution to increase hyperthermia effect to the desired areas in the body by accumulation and increasing local concentration due to high tissue metabolic assimilation. In this condition, it is considered that the magnetization of the nanoparticles is a single-giant magnetic moment, the sum of all the individual magnetic moments and is proportional to the concentration of Glc-Fe-MNP.
authors.affiliation: a Department of Medical Physics and Biophysics , Faculty of Medicine, Medical University-Sofia , Sofia , Bulgaria .
authors.forename: L
authors.initials: L
authors.lastname: Traikov
authors.affiliation: a Department of Medical Physics and Biophysics , Faculty of Medicine, Medical University-Sofia , Sofia , Bulgaria .
authors.forename: I
authors.initials: I
authors.lastname: Antonov
authors.affiliation: a Department of Medical Physics and Biophysics , Faculty of Medicine, Medical University-Sofia , Sofia , Bulgaria .
authors.forename: A
authors.initials: A
authors.lastname: Gerou
authors.affiliation: b Military Medical Academy, MHAT Sofia, MMDER/Clinic of Physical and Rehabilitation Medicine , Sofia , Bulgaria .
authors.forename: L
authors.initials: L
authors.lastname: Vesselinova
authors.affiliation: c Department of Pathophysiology , Faculty of Medicine, Medical University-Sofia , Sofia , Bulgaria , and.
authors.forename: R
authors.initials: R
authors.lastname: Hadjiolova
authors.affiliation: d Military Medical Academy, MHAT Sofia, Clinic of Hematology , Sofia , Bulgaria.
authors.forename: J
authors.initials: J
authors.lastname: Raynov
mesh_terms: D000818:Animals; D004574:Electromagnetic Fields; D005260:Female; D005947:Glucose / Q000737:chemistry* / Q000378:metabolism*; D006979:Hyperthermia, Induced / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000628:therapy; D010865:Pilot Projects; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
chemical_list: D058185:Magnetite Nanoparticles; D005947:Glucose
keywords: EMF therapy; Electromagnetic field; hyperthermia; in vivo