title: Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii.
abstract: Three unprecedented phloroglucinol-diterpene adducts, chlorabietols A-C (1-3), were isolated from the roots of the rare Chloranthaceae plant Chloranthus oldhamii. They represent a new class of compounds, featuring an abietane-type diterpenoid coupled with different alkenyl phloroglucinol units by forming a 2,3-dihydrofuran ring. Their structures were elucidated by detailed spectroscopic analysis, molecular modeling studies, and electronic circular dichroism calculations. Compounds 1-3 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 12.6, 5.3, and 4.9 μM, respectively.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University , No. 826 Zhangheng Road, Shanghai 201203, P. R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University , No. 826 Zhangheng Road, Shanghai 201203, P. R. China.
authors.forename: Zhi-Lai
authors.initials: ZL
authors.lastname: Hong
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , No. 555 Zuchongzhi Road, Shanghai 201203, P. R. China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Gao
authors.affiliation: Institute of Bioengineering and Nanotechnology , 31 Biopolis Way, The Nanos 138669, Singapore.
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University , No. 826 Zhangheng Road, Shanghai 201203, P. R. China.
authors.forename: Shu-Ting
authors.initials: ST
authors.lastname: Liu
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University , No. 826 Zhangheng Road, Shanghai 201203, P. R. China.
authors.forename: Guo-Xun
authors.initials: GX
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , No. 555 Zuchongzhi Road, Shanghai 201203, P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Institute of Bioengineering and Nanotechnology , 31 Biopolis Way, The Nanos 138669, Singapore.
authors.forename: Huaqiang
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University , No. 826 Zhangheng Road, Shanghai 201203, P. R. China.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
mesh_terms: D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010696:Phloroglucinol / Q000737:chemistry* / Q000302:isolation & purification; D018517:Plant Roots; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004224:Diterpenes; D005663:Furans; C000606350:chlorabietol A; C000606351:chlorabietol B; C000606352:chlorabietol C; C073812:2,3-dihydrofuran; D010696:Phloroglucinol; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1