title: Molecular diagnostics of neurodegenerative disorders.
abstract: Molecular diagnostics provide a powerful method to detect and diagnose various neurological diseases such as Alzheimer's and Parkinson's disease. The confirmation of such diagnosis allows early detection and subsequent medical counseling that help specific patients to undergo clinically important drug trials. This provides a medical pathway to have better insight of neurogenesis and eventual cure of the neurodegenerative diseases. In this short review, we present recent advances in molecular diagnostics especially biomarkers and imaging spectroscopy for neurological diseases. We describe advances made in Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD), and finally present a perspective on the future directions to provide a framework for further developments and refinements of molecular diagnostics to combat neurodegenerative disorders.
authors.affiliation: Department of Biology, University of Arkansas at Little Rock Little Rock, AR, USA.
authors.forename: Megha
authors.initials: M
authors.lastname: Agrawal
authors.affiliation: Department of Electrical Engineering, Center for Nano Science and Technology, University of Notre Dame Notre Dame, IN, USA.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Biswas
keywords: Alzheimer's disease; Amyotrophic lateral sclerosis; Huntington's disease; Parkinson's disease; biomarkers; miRNAs; neurodegeneration; neurons