title: Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384.
abstract: Eighteen different Pearson mutual-positive-correlation BIK-activatory molecular feedback upstream and downstream networks were constructed from 79 overlapping of 376 GRNInfer and 98 Pearson under BIK CC ≥ 0.25 in low normal adjacent tissues of Taiwan compared with high lung adenocarcinoma. Our identified BIK interactive total feedback molecular network showed FUT3 [fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase Lewis blood group)], PMM2 (phosphomannomutase 2), SQSTM1 (sequestosome 1), SFN_2 [REX2 RNA exonuclease 2 homolog (S. cerevisiae)] and ZNF384 (zinc finger protein 384) in low normal adjacent tissues of lung adenocarcinoma. BIK interactive total feedback terms included mitochondrial envelope, endomembrane system, integral to membrane, Golgi apparatus, cytoplasm, nucleus, cytosol, intracellular signaling cascade, mitochondrion, extracellular space, inflammation, immune response, apoptosis, cell differentiation, cell cycle, regulation of cell cycle, cell proliferation, estrogen-responsive protein Efp controls cell cycle and breast tumors growth, induction or regulation of apoptosis based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases in low normal adjacent tissues of lung adenocarcinoma. Therefore, we propose low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384 in normal adjacent tissues of lung adenocarcinoma.
authors.affiliation: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
authors.forename: Juxiang
authors.initials: J
authors.lastname: Huang
authors.affiliation: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China. wanglin98@tsinghua.org.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Lab of Computational Linguistics, School of Humanities and Social Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Minghu
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
authors.forename: Yangming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
authors.forename: Zhenfu
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: College of Information, North China University of Technology, Beijing, 100043, China.
authors.forename: Zhongjie
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D048948:14-3-3 Proteins / Q000235:genetics; D000230:Adenocarcinoma / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D000077192:Adenocarcinoma of Lung; D017209:Apoptosis / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics; D019295:Computational Biology / Q000379:methods; D005095:Exoribonucleases / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D024101:Mitochondrial Proteins; D017875:Phosphotransferases (Phosphomutases) / Q000235:genetics; D000071456:Sequestosome-1 Protein / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D048948:14-3-3 Proteins; D051017:Apoptosis Regulatory Proteins; C096820:BIK protein, human; D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein; D015534:Trans-Activators; C498621:ZNF384 protein, human; D005095:Exoribonucleases; C413442:SFN protein, human; D017875:Phosphotransferases (Phosphomutases); C519582:phosphomannomutase 2, human
keywords: Apoptosis; BIK interactive network; Inflammation immune; Outside-inside-out; Transcription-dependent