title: Knee and hip radiographic osteoarthritis features: differences on pain, function and quality of life.
abstract: The association between radiographic osteoarthritis (OA) and symptoms is inconsistent and variable according to each joint. The purpose of this study is to understand the relation between radiographic OA features, pain, function and quality of life, in knee and hip joints. A cross-sectional study was performed using information from EPIPorto cohort. Data was obtained by interview using a structured questionnaire on social, demographic, behavioural and clinical data. Pain was assessed using a pain frequency score (regarding ever having knee pain, pain in the last year, in the last 6 months and in the last month). Quality of life was evaluated with Short Form 36 (SF-36) and function disability with the Lequesne knee and hip indexes. Radiographic knees and hips were classified using the Kellgren-Lawrence score (KL 0-4). Linear regression and proportional odds ratios estimated the association between radiographic features, pain, function and quality of life. In our study, symptomatic OA (KL ≥ 2 plus joint pain) was 26.0 % in knee and 7.0 % hip joints. In knee, the increase on radiographic score increased the odds to have a higher pain frequency score [1.58 (95 % CI = 1.27, 1.97)] and was associated [adjusted β (95 % CI)] with worst general health [-3.05 (-5.00, -1.09)], physical function [-4.92 (-7.03, -2.80)], role-physical [-4.10 (-8.08, -0.11)], bodily pain [-2.96 (-5.45, -0.48)] and limitations in activities of daily living [0.48 (0.08, 0.89)]. Regarding hip, no significant associations were found between the severity of radiographic lesions and these measures. Radiographic lesions in knee were associated with higher complaints, as far as pain and functional limitations are concerned, compared with hip.
authors.affiliation: Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, 4200-319, Porto, Portugal. duartefisio@hotmail.com.|EPI Unit, Public Health Institute, University of Porto, Porto, Portugal. duartefisio@hotmail.com.
authors.forename: Duarte
authors.identifier: http://orcid.org/0000-0002-3183-0395
authors.initials: D
authors.lastname: Pereira
authors.affiliation: Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, 4200-319, Porto, Portugal.|EPI Unit, Public Health Institute, University of Porto, Porto, Portugal.
authors.forename: Milton
authors.initials: M
authors.lastname: Severo
authors.affiliation: Hospital Beatriz Ângelo, Loures, Portugal.
authors.forename: Rui A
authors.initials: RA
authors.lastname: Santos
authors.affiliation: Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, 4200-319, Porto, Portugal.|EPI Unit, Public Health Institute, University of Porto, Porto, Portugal.
authors.forename: Henrique
authors.initials: H
authors.lastname: Barros
authors.affiliation: CEDOC, Nova Medical School/Faculdade de Ciências Médicas, Rheumatology Department, Universidade Nova de Lisboa, CHLO, EPE-Hospital Egas Moniz, Lisboa, Portugal.
authors.forename: Jaime
authors.initials: J
authors.lastname: Branco
authors.affiliation: Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, 4200-319, Porto, Portugal.|EPI Unit, Public Health Institute, University of Porto, Porto, Portugal.
authors.forename: Raquel
authors.initials: R
authors.lastname: Lucas
authors.affiliation: Rheumatology Department, EPE-Hospital S. João, Porto, Portugal.
authors.forename: Lúcia
authors.initials: L
authors.lastname: Costa
authors.affiliation: Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, 4200-319, Porto, Portugal.|EPI Unit, Public Health Institute, University of Porto, Porto, Portugal.
authors.forename: Elisabete
authors.initials: E
authors.lastname: Ramos
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D018771:Arthralgia / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging*; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging* / Q000503:physiopathology; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010147:Pain Measurement; D011174:Portugal; D011788:Quality of Life; D011859:Radiography; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
keywords: Disability; Hip; Knee; Osteoarthritis; Pain; Quality of life