title: Burden of serious fungal diseases in Hungary.
abstract: Valid data on the prevalence of serious fungal diseases are difficult to derive as in most countries these conditions are not reportable infections. To assess the burden of these infections in Hungary prevalence estimates from international peer-reviewed papers and population statistics were utilised. In the intensive care unit (ICU) population at least 370 cases of serious yeast and 52 mould infections can be expected yearly. The total number of candidaemia cases may be as high as 1110 annually. In patients with acute leukaemia and recipients of haematopoietic stem cell and solid organ transplants the predicted incidence is more than 55 every year. Recurrent vulvovaginal candidiasis--though not a life-threatening condition--can adversely affect the quality of life of more than 177,000 Hungarian women. According to organisation for economic co-operation and development (OECD), 4.7% of total population older than 15 will suffer from chronic obstructive pulmonary disease (COPD) and 4.4% from asthma, adding another very broad risk group to the aforementioned categories susceptible for mycotic complications. Here more than 17,000 can have severe asthma with fungal sensitisation (SAFS) and more than 13,000 are at risk for developing allergic bronchopulmonary aspergillosis (ABPA). The incidence of dermatomycoses and other superficial fungal infections is even more difficult to assess but--according to international estimations--can affect around 14.3% of the total population. More than 1.6 million Hungarians may suffer from fungal diseases annually, with 33,000 cases being life threatening or very serious. This is an under-recognised problem of special importance for public health.
authors.affiliation: Szent István and Szent László Hospital, Budapest, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Sinkó
authors.affiliation: Szent István and Szent László Hospital, Budapest, Hungary.
authors.forename: Mihály
authors.initials: M
authors.lastname: Sulyok
authors.affiliation: The University of Manchester, Manchester Academic Health Sciences Centre and the National Aspergillosis Centre, Manchester, UK.
authors.forename: David W
authors.initials: DW
authors.lastname: Denning
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000453:epidemiology / Q000382:microbiology; D001249:Asthma / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D058387:Candidemia / Q000453:epidemiology / Q000382:microbiology; D002181:Candidiasis, Vulvovaginal / Q000453:epidemiology / Q000382:microbiology; D017281:Cost of Illness; D003881:Dermatomycoses / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D008875:Middle Aged; D009181:Mycoses / Q000453:epidemiology* / Q000382:microbiology; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D011788:Quality of Life; D055815:Young Adult
chemical_list: D000485:Allergens
keywords: Aspergillosis; candidiasis; epidemiology; invasive fungal disease