title: Spontaneous regression of laryngeal squamous cell carcinoma.
abstract: BACKGROUND
  Spontaneous regression of solid malignancy is extremely rare. It is virtually unheard of in the last half century in the published literature. The overwhelming majority of medical professionals do not know that this phenomenon exists.
  
  
  METHODS
  This paper reports such a case involving a patient with proven laryngeal squamous cell carcinoma in New Zealand. Whilst waiting for definitive treatment, he was afflicted with prolonged septicaemia secondary to peritonitis from percutaneous endoscopic gastrostomy tube insertion. Following a total laryngectomy, histology of the specimen did not contain any evidence of neoplasia.
  
  
  CONCLUSIONS
  Based predominantly on work established by Dr William Coley, we believe that a period of prolonged pyrexia preceding definitive surgery contributed to this apparent 'miracle'. The time may be ripe to further debate on whether the medical profession should consider pyrexia therapy as a last resort treatment for patients deemed incurable by conventional methods.
authors.affiliation: ENT Department,Southampton General Hospital,UK.
authors.forename: F
authors.initials: F
authors.lastname: Sipaul
authors.affiliation: Department of ENT,Christchurch Public Hospital,New Zealand.
authors.forename: B
authors.initials: B
authors.lastname: Ling
authors.affiliation: Department of Pathology,Christchurch Public Hospital,New Zealand.
authors.forename: C
authors.initials: C
authors.lastname: Mason
authors.affiliation: Department of ENT,Christchurch Public Hospital,New Zealand.
authors.forename: A
authors.initials: A
authors.lastname: Keast
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D059248:Chemoradiotherapy / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D012075:Remission, Spontaneous; D018570:Risk Assessment; D013997:Time Factors
keywords: Immunotherapy; Larynx; Pyrexia; Spontaneous Neoplasm Regression; Squamous Cell Carcinoma