title: Preliminary study of IVIM-DWI and DCE-MRI in early diagnosis of esophageal cancer.
abstract: OBJECTIVE
  To investigate the application value of double exponential model diffusion weighted imaging (IVIM-DWI) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in the diagnosis of early esophageal cancer.
  
  
  METHODS
  30 cases of patients with early esophageal cancer confirmed by pathology were collected. They were performed MRI plain scan, IVIM-DWI and DCE-MRI scan. The normal esophageal tissue, SlowADC value in tumor focus, FastADC value, F value, Ktrans, Kep and Ve values were measured. The difference between cancer tissue and normal tissue was compared using two independent sample t test. The prediction parameters and diagnostic threshold were compared by drawing receiver operating characteristic curve (ROC).
  
  
  RESULTS
  The average F, Ktrans and Kep values in esophageal cancer and normal esophageal tissue were: (0.48 ± 0.19), (0.64 ± 0.08); (0.45 ± 0.19)/min, (0.14 ± 0.04)/min and (1.14 ± 0.42)/min, (0.56 ± 0.25)/min respectively. Compared with normal esophageal tissue, esophageal cancer F value decreased, Ktrans value increased, Kep value increased, and the difference was statistically significant (p < 0.05); There was no difference in SlowADC, FastADC, Ve values of esophageal cancer and those in normal esophageal tissues (p > 0.05). The areas under ROC curve F, Ktrans and Kep values were 0.90, 0.98 and 0.92 respectively. They had the higher diagnostic efficiency.
  
  
  CONCLUSIONS
  IVIM-DWI and DCE-MRI can be used as the imaging method to diagnose esophageal malignant tumor, which has the higher diagnostic value.
authors.affiliation: Xinxiang Medical University, Xinxiang, China. shaochengzhucn@126.com.
authors.forename: J
authors.initials: J
authors.lastname: Lei
authors.forename: Y
authors.initials: Y
authors.lastname: Tian
authors.forename: S-C
authors.initials: SC
authors.lastname: Zhu
authors.forename: Q
authors.initials: Q
authors.lastname: Han
authors.forename: Y
authors.initials: Y
authors.lastname: Wei
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: D-P
authors.initials: DP
authors.lastname: Shi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D055088:Early Detection of Cancer; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D008875:Middle Aged