title: The effect of a streptococci containing probiotic in periodontal therapy: a randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the adjunctive effects of a Streptococcus oralis KJ3, Streptococcus uberis KJ2 and Streptococcus rattus JH145 containing probiotic tablet after scaling and root planing (SRP).
  
  
  METHODS
  Forty-eight periodontitis patients were included in this double-blind, placebo-controlled clinical trial. After root planing, patients used either a placebo or a probiotic tablet twice a day for 12 weeks. The pocket probing depth (primary outcome measure), bleeding on probing and relative attachment levels were measured at baseline, 12 and 24 weeks. At baseline, 4, 8, 12 and 24 weeks, microbiological sampling was performed and plaque and gingival indices were recorded.
  
  
  RESULTS
  The primary and secondary outcome measures were significantly (p < 0.05) improved at the 12- and the 24-week evaluation in both groups. However, no significant inter-group differences could be detected at any time point, except from the % of sites with plaque that were significantly lower in the probiotic group than in the control group at the 24-week evaluation. In addition, at the 12-week time point, the salivary Prevotella intermedia counts were significantly lower in the probiotic group.
  
  
  CONCLUSIONS
  No differences were detected when comparing the adjunctive use of a placebo or the investigated streptococci containing probiotic tablet after SRP. ClinicalTrials.gov Identifier: NCT02403960.
authors.affiliation: Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Laleman
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Cukurova Univerisity, Adana, Turkey.
authors.forename: Eftal
authors.initials: E
authors.lastname: Yilmaz
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Cukurova Univerisity, Adana, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Ozcelik
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Cukurova Univerisity, Adana, Turkey.
authors.forename: Cenk
authors.initials: C
authors.lastname: Haytac
authors.affiliation: Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Martine
authors.initials: M
authors.lastname: Pauwels
authors.affiliation: Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Esteban R
authors.initials: ER
authors.lastname: Herrero
authors.affiliation: Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Vera
authors.initials: V
authors.lastname: Slomka
authors.affiliation: Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Quirynen
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Cukurova Univerisity, Adana, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Alkaya
authors.affiliation: Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Wim
authors.initials: W
authors.lastname: Teughels
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents; D012534:Dental Scaling; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000188:drug therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy; D010518:Periodontitis / Q000188:drug therapy; D019936:Probiotics; D016745:Root Planing
chemical_list: D000900:Anti-Bacterial Agents
keywords: periodontitis; probiotic tablet; probiotics; scaling and root planing; streptococci; treatment