title: Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review.
abstract: BACKGROUND
  Chalcones are one of the major classes of naturally occurring compounds and have a vast significance in medicinal chemistry, presenting with a wide scope of pharmacological actions.
  
  
  CONCLUSIONS
  The present review focused our attention onto the monoamine oxidase inhibitory activity of natural and synthetic chalcones. The review also emphasises the structure-activity relationship studies and molecular recognition of chalcones towards MAO-A and B inhibition.
  
  
  CONCLUSIONS
  Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A. Recent studies also showed that heteroaryl-based chalcones are potent MAO-A inhibitors.
authors.affiliation: Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Grace, College of Pharmacy, Palakkad -678004, Kerala, India. bijovilaventgu@gmail.com.
authors.forename: Bijo
authors.initials: B
authors.lastname: Mathew
authors.forename: Abitha
authors.initials: A
authors.lastname: Haridas
authors.forename: Jerad
authors.initials: J
authors.lastname: Suresh
authors.forename: Githa E
authors.initials: GE
authors.lastname: Mathew
authors.forename: Gülberk
authors.initials: G
authors.lastname: Uçar
authors.forename: Venkatesan
authors.initials: V
authors.lastname: Jayaprakash
mesh_terms: D000818:Animals; D047188:Chalcones / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008995:Monoamine Oxidase / Q000737:chemistry* / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D047188:Chalcones; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human