title: Cytokine release in patients with CLL treated with obinutuzumab and possible relationship with infusion-related reactions.
authors.affiliation: Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, United Kingdom.
authors.forename: Ciara L
authors.identifier: http://orcid.org/0000-0001-5099-2843
authors.initials: CL
authors.lastname: Freeman
authors.affiliation: Hematology, Centre Hospitalier Régional Universitaire de Lille, Unité Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA), Université de Lille, Lille, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Morschhauser
authors.affiliation: Centre for Lymphoid Cancer, British Columbia Cancer Agency and the University of British Columbia, Vancouver, BC, Canada.
authors.forename: Laurie
authors.initials: L
authors.lastname: Sehn
authors.affiliation: Department of Biostatistics and Department of Statistical Programming and Analysis, Roche Products Limited, Welwyn Garden City, United Kingdom.
authors.forename: Mark
authors.initials: M
authors.lastname: Dixon
authors.affiliation: Department of Biostatistics and Department of Statistical Programming and Analysis, Roche Products Limited, Welwyn Garden City, United Kingdom.
authors.forename: Richard
authors.initials: R
authors.lastname: Houghton
authors.affiliation: Centre Hospitalier Universitaire de Rennes (CHU Rennes), Rennes, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Lamy
authors.affiliation: Pharma Development Oncology, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
authors.forename: Günter
authors.initials: G
authors.lastname: Fingerle-Rowson
authors.affiliation: Pharma Development Oncology, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Wassner-Fritsch
authors.affiliation: Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, United Kingdom.
authors.forename: John G
authors.initials: JG
authors.lastname: Gribben
authors.affiliation: Department of Internal Medicine, Center of Integrated Oncology & Cologne Center of Excellence for Cellular Stress Response and Aging Related Diseases (CECAD), University of Cologne, Cologne, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Hallek
authors.affiliation: Hospices Civils de Lyon, Université Claude Bernard, Lyon, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Salles
authors.affiliation: Department of Clinical Hematology, Centre Hospitalier Régional Universitaire, Université de Montpellier, Montpellier, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Cartron
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000187:drug effects; D019559:Capillary Leak Syndrome / Q000139:chemically induced; D017321:Clinical Trials, Phase I as Topic / Q000706:statistics & numerical data; D017322:Clinical Trials, Phase II as Topic / Q000706:statistics & numerical data; D016207:Cytokines / Q000378:metabolism*; D004487:Edema / Q000139:chemically induced; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D000860:Hypoxia / Q000139:chemically induced; D007262:Infusions, Intravenous; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000503:physiopathology; D008212:Lymphocyte Depletion; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D013577:Syndrome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; C508606:CXCL8 protein, human; D016207:Cytokines; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; C543332:obinutuzumab