title: Effects of periodontal therapy on serum lipid profile and proinflammatory cytokines in patients with hyperlipidemia: a randomized controlled trial.
abstract: OBJECTIVE
  The aim of this study was to evaluate whether periodontal treatment in patients with periodontitis and hyperlipidemia may have any influence on plasma lipids and pro-inflammatory cytokine levels.
  
  
  METHODS
  We randomly assigned 109 patients with hyperlipidemia and chronic periodontitis into group 1 (n = 55) and group 2 (n = 54). Patients in group 1 underwent a standard cycle of supragingival mechanical scaling and polishing. Patients in group 2 underwent the adjunctive full-mouth intensive removal of subgingival dental plaque biofilms with the use of scaling and root planning. Periodontal parameters, total cholesterol (TC), triglyceride (TRG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), tumor necrosis factor-alpha (TNF-α), interleukin(IL)-1β(IL-1β), and IL-6 were evaluated before treatment and 2 and 6 months after treatment.
  
  
  RESULTS
  Two and 6 months after treatment, TRG levels were significantly lower in group 2 than in group 1 (P < 0.05), and the levels of HDL-C were significantly higher (P < 0.05). Two and 6 months after therapy, the levels of TNF-α were significantly lower in group 2 than in group 1 (P < 0.05), as were the levels of IL-1β (P < 0.001) and IL-6 (P < 0.001).
  
  
  CONCLUSIONS
  Intensive periodontal treatment of participants with hyperlipidemia and chronic periodontitis improved serum lipid levels and decreased circulating pro-inflammatory cytokine levels.
  
  
  CONCLUSIONS
  This study showed that intensive treatment of periodontitis results in an improvement in serum lipid levels and a decrease in serum proinflammatory cytokine levels in patients with periodontitis and hyperlipidemia. These findings may contribute to present knowledge that periodontal therapy may be beneficial for individuals with hyperlipidemia.
authors.affiliation: Department of Stomatology, The First People's Hospital of Lianyungang City, Lianyungang, 222002, Jiangsu Province, China. fuyongweivip@sina.com.
authors.forename: Yong-Wei
authors.initials: YW
authors.lastname: Fu
authors.affiliation: Department of Stomatology, The First People's Hospital of Lianyungang City, Lianyungang, 222002, Jiangsu Province, China.
authors.forename: Xiang-Xin
authors.initials: XX
authors.lastname: Li
authors.affiliation: Department of Stomatology, The First People's Hospital of Lianyungang City, Lianyungang, 222002, Jiangsu Province, China.
authors.forename: Hong-Zhi
authors.initials: HZ
authors.lastname: Xu
authors.affiliation: Department of Stomatology, The First People's Hospital of Lianyungang City, Lianyungang, 222002, Jiangsu Province, China.
authors.forename: Yong-Qing
authors.initials: YQ
authors.lastname: Gong
authors.affiliation: Department of Stomatology, The First People's Hospital of Lianyungang City, Lianyungang, 222002, Jiangsu Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
mesh_terms: D018441:Biofilms; D055113:Chronic Periodontitis / Q000097:blood* / Q000628:therapy*; D016207:Cytokines / Q000097:blood*; D012534:Dental Scaling; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged
chemical_list: D016207:Cytokines
keywords: Cholesterol; Cytokines; Hyperlipidemia; Periodontitis