title: Benefits of a Dual Chemical and Physical Activation: Direct aza-Michael Addition of Anilines Promoted by Solvent Effect under High Pressure.
abstract: The unique combination of hexafluoroisopropanol (HFIP) employed as solvent and hyperbaric conditions (10-15 kbar) allows unprecedented 1,4-addition of poor nucleophiles, such as aromatic amines, onto sluggish (cumbersome) Michael acceptors without any promoter or workup.
authors.affiliation: Laboratory COBRA UMR 6014, Normandie Université, Université de Rouen, INSA Rouen and CNRS, IRCOF , 1 rue Lucien Tesnière, 76821 Mont-Saint-Aignan, France.|A. E. Favorsky Institute of Chemistry, Siberian Division of the Russian Academy of Sciences , 1 Favorsky Street, Irkutsk 664033, Russia.
authors.forename: Alena
authors.initials: A
authors.lastname: Fedotova
authors.affiliation: BioCIS UMR 8076, Labex LERMIT, Université Paris Sud, and CNRS , 5 rue J. B. Clément, 92296 Châtenay-Malabry, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Crousse
authors.affiliation: Laboratory COBRA UMR 6014, Normandie Université, Université de Rouen, INSA Rouen and CNRS, IRCOF , 1 rue Lucien Tesnière, 76821 Mont-Saint-Aignan, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chataigner
authors.affiliation: Laboratory COBRA UMR 6014, Normandie Université, Université de Rouen, INSA Rouen and CNRS, IRCOF , 1 rue Lucien Tesnière, 76821 Mont-Saint-Aignan, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Maddaluno
authors.affiliation: A. E. Favorsky Institute of Chemistry, Siberian Division of the Russian Academy of Sciences , 1 Favorsky Street, Irkutsk 664033, Russia.
authors.forename: Alexander Yu
authors.initials: AY
authors.lastname: Rulev
authors.affiliation: Laboratory COBRA UMR 6014, Normandie Université, Université de Rouen, INSA Rouen and CNRS, IRCOF , 1 rue Lucien Tesnière, 76821 Mont-Saint-Aignan, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Legros