title: Association of matrix metalloproteinase-10 polymorphisms with susceptibility to pelvic organ prolapse.
abstract: OBJECTIVE
  The aim of this study was to explore the correlation between genetic mutations in matrix metalloproteinase-10 (MMP-10) and susceptibility to pelvic organ prolapse (POP).
  
  
  METHODS
  From September 2011 to December 2013, 263 subjects were recruited, including 91 patients with POP (case group) and 172 non-POP patients (control group). Total MMP-10 concentrations in serum were measured by enzyme-linked immunosorbent assay. The genotyping of MMP-10 was achieved by quantitative real-time polymerase chain reaction. All data were analyzed with SPSS 18.0.
  
  
  RESULTS
  We found that parity, menopause, history of total hysterectomy, and family history of POP were all significantly higher in the POP group than in the control group (P = 0.017, P = 0.046, P = 0.0029 and P < 0.001, respectively). Serum MMP-10 levels were obviously higher in the POP group than in the control group (P < 0.05). In addition, there was a statistically significant difference between the two groups in the distribution frequency of the MMP-10 (rs17435959G/C) genotype (P < 0.05). However, the distribution frequency of the MMP-10 (rs17293607C/T) genotype between the two groups showed no significant differences (P > 0.05). Furthermore, the patients with parity > 2 and postmenopausal women had elevated serum MMP-10 levels, and the patients with parity > 2 and postmenopausal women who carried the G/C + C/C genotype in the MMP-10 gene had an increased risk of POP.
  
  
  CONCLUSIONS
  We support the view that the rs17435959 polymorphism of the MMP-10 gene may be associated with an increased risk of POP.
authors.affiliation: Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, The Affiliated Hospital of Capital Medical University, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, The Affiliated Hospital of Capital Medical University, Beijing, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, The Affiliated Hospital of Capital Medical University, Beijing, China.
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, The Affiliated Hospital of Capital Medical University, Beijing, China.
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Lu
authors.affiliation: Department of Obstetrics and Gynecology, China Meitan General Hospital, Beijing, China.
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, The Affiliated Hospital of Capital Medical University, Beijing, China.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D000368:Aged; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053506:Matrix Metalloproteinase 10 / Q000097:blood / Q000235:genetics*; D008593:Menopause; D008875:Middle Aged; D010298:Parity; D056887:Pelvic Organ Prolapse / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C511770:MMP10 protein, human; D053506:Matrix Metalloproteinase 10
keywords: genetic polymorphisms; matrix metalloproteinase-10; pelvic organ prolapse; susceptibility