title: Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats.
abstract: The present study was conducted to evaluate the ameliorative efficacy of Spirulina platensis (SP) on reproductive dysfunctions induced by cadmium chloride (CdCl2) in male rats. Rats (n = 40) were divided into five groups (eight rats/each). Group 1: served as control without any treatment. Group 2: Rats were administered SP (150 mg/kg body weight (BW)) in drinking water for 10 days. Group 3: Rats were subcutaneously injected with CdCl2 (2 mg/kg BW) daily for 10 days. Group 4: Rats were co-treated with both CdCl2 (2 mg/kg BW) and SP (150 mg/kg BW) daily for 10 days (SP prophylactic group). Group 5: Rats received CdCl2 for 10 days followed by administration of SP alone in drinking water daily for another 30 days with the same mentioned routes and doses (SP treatment group). From our findings, the administration of SP alone or co-administration with Cd significantly attenuated the harmful effects of Cd, suggesting its beneficial role in improving spermatogenesis and steroidogenesis after Cd exposure.
authors.affiliation: Department of Forensic Medicine and Toxicology, Zagazig University, Zagazig, 44111, Egypt. dr.mayadarf@gmail.com.
authors.forename: Mayada R
authors.initials: MR
authors.lastname: Farag
authors.affiliation: Department of Physiology, Zagazig University, Zagazig, 44111, Egypt.
authors.forename: R M
authors.initials: RM
authors.lastname: Abd El-Aziz
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44111, Egypt.
authors.forename: H A
authors.initials: HA
authors.lastname: Ali
authors.affiliation: Department of Forensic Medicine and clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, 44111, Egypt.
authors.forename: Sahar A
authors.initials: SA
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D019256:Cadmium Chloride / Q000633:toxicity*; D008297:Male; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D053545:Spirulina
chemical_list: D019256:Cadmium Chloride
keywords: Cadmium; Rat; Spermatogenesis; Spirulina platensis; Steroidogenesis