title: Correlation between Microvascular Density and Matrix Metalloproteinase 11 Expression in Prostate Cancer Tissues: a Preliminary Study in Thailand.
abstract: BACKGROUND
  Prostate cancer is a major concern of public health. Microvascular density (MVD) is one of the prognostic markers for various solid cancers. Matrix metalloproteinase 11 (MMP11) plays an important role in angiogenesis and changes in its expression level are known to be associated with tumor progression and clinical outcome.
  
  
  OBJECTIVE
  To investigate the relationship between MVD and MMP11 expression in prostatic adenocarcinoma tissues.
  
  
  METHODS
  The expression levels of MMP11 and MVD were analyzed immunohistochemically for 50 specimens of prostatic adenocarcinoma.
  
  
  RESULTS
  MMP11 was mainly expressed in stromal cells but rarely seen in epithelial cells. Mean MVD was 36/mm2, and it was correlated significantly only with bone metastases. MVD was also significantly correlated with MMP11 expression (r=0.29, p=0.044).
  
  
  CONCLUSIONS
  MMP11 may alter the stromal microenvironment of prostate cancer to stimulate tumor angiogenesis.
authors.affiliation: College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, Thailand E-mail : panya@kku.ac.th.
authors.forename: Nongnuch
authors.initials: N
authors.lastname: Kanharat
authors.forename: Panya
authors.initials: P
authors.lastname: Tuamsuk
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000737:chemistry* / Q000556:secondary; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000556:secondary*; D004847:Epithelial Cells / Q000737:chemistry; D006801:Humans; D008297:Male; D053507:Matrix Metalloproteinase 11 / Q000032:analysis*; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000737:chemistry* / Q000473:pathology; D017154:Stromal Cells / Q000737:chemistry; D013785:Thailand
chemical_list: D053507:Matrix Metalloproteinase 11