title: Injectable 2D MoS2 -Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia.
abstract: MoS2 nanosheets and a doxorubicin (DOX)-containing poly (lactic-co-glycolic acid) (PLGA)/MoS2 /DOX composite implant are successfully constructed based on the unique phase-changing behavior of PLGA/MoS2 /DOX oleosol within tumors. The fast phase transformation can firmly restrict MoS2 and DOX within tumors, and the integrated MoS2 and DOX can endow the implant with high synergistic photothermal and chemotherapeutic efficiency against tumors.
authors.affiliation: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050, P. R. China.|Tin Ka Ping College of Science, University of Shanghai for Science and Technology, Shanghai, 200093, P. R. China.
authors.forename: Shige
authors.initials: S
authors.lastname: Wang
authors.affiliation: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Breast-Thyroid Surrey, Shanghai First People Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, P. R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050, P. R. China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Breast-Thyroid Surrey, Shanghai First People Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
authors.forename: Yuanyi
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050, P. R. China.
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.affiliation: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050, P. R. China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D002460:Cell Line; D004220:Disulfides / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays; D007267:Injections; D019344:Lactic Acid / Q000737:chemistry; D007834:Lasers; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D008982:Molybdenum / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D019736:Prostheses and Implants
chemical_list: D004220:Disulfides; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin; D008982:Molybdenum; C082964:molybdenum disulfide
keywords: composite implants; drug delivery; molybdenum disulfides; photothermal therapies; synergistic tumor therapy