title: Micro-optical coherence tomography tracking of magnetic gene transfection via Au-Fe3O4 dumbbell nanoparticles.
abstract: Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT.
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Xinyu
authors.initials: X
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Wei
authors.forename: Zhichuan J
authors.initials: ZJ
authors.lastname: Xu
authors.forename: Stanley Siong Wei
authors.initials: SS
authors.lastname: Sim
authors.forename: Linbo
authors.initials: L
authors.lastname: Liu
authors.forename: Chenjie
authors.initials: C
authors.lastname: Xu
mesh_terms: D005290:Ferric Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014162:Transfection / Q000379:methods*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D006046:Gold