title: Nanobiotechnological Approaches Against Multidrug Resistant Bacterial Pathogens: An Update.
abstract: Multiple drug resistant bacteria remain the greatest challenge in public health care. Globally, infections produced by such resistant strains are on the rise. Recent advent of genetic tolerance to antibiotics in many pathogens such as multiple drug resistant Staphylococcus aureus is a matter of concern, prompting researchers and pharmaceutical companies to search for new molecules and unconventional antibacterial agents. Recent advances in nanotechnology offer new opportunities to develop formulations based on metallic nanoparticles with different shapes and sizes and variable antimicrobial properties. This article is an extensive literature review that covers the latest approaches in the development of new and unconventional antibacterial agents using nanobiotechnological approaches which will better equip scientists and clinicians to face the challenges in view of dwindling stocks of effective and potent antimicrobial agents and formulations.
authors.forename: Sibhghatulla
authors.initials: S
authors.lastname: Shaikh
authors.forename: Shazi
authors.initials: S
authors.lastname: Shakil
authors.forename: Adel M
authors.initials: AM
authors.lastname: Abuzenadah
authors.forename: Syed Mohd Danish
authors.initials: SM
authors.lastname: Rizvi
authors.forename: Philip Michael
authors.initials: PM
authors.lastname: Roberts
authors.forename: Gohar
authors.initials: G
authors.lastname: Mushtaq
authors.affiliation: Center of Innovation in Personalized Medicine, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia-21589. shazibiotech@gmail.com.
authors.forename: Mohammad Amjad
authors.initials: MA
authors.lastname: Kamal
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D001709:Biotechnology / Q000379:methods; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial; D014943:Global Health; D006801:Humans; D053768:Metal Nanoparticles; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size
chemical_list: D000900:Anti-Bacterial Agents