title: Seroepidemiology of mumps in the general population of Jiangsu province, China after introduction of a one-dose measles-mumps-rubella vaccine.
abstract: The mumps surveillance data from 2004 to 2011 showed that the incidence of mumps remained high after the one-dose measles-mumps-rubella (MMR) vaccine was introduced in China in 2008. A cross-sectional survey of mumps IgG in the general population of Jiangsu province was conducted in 2012 to gain comprehensive information on the immunity profile of the general population. The mean incidence was 15.2 per 100 000 individuals in Jiangsu province from 2004-2013. Two mumps incidence peaks were observed each year after introduction of the one-dose MMR vaccine. The seroprevalence did not significantly differ by region or sex, while the GMC significantly differed by region and sex. The overall GMC in Jiangsu province was 99.1 IU/ml (95% CI: 90.1-108.2), while the seroprevalence was only 59.1% (95% CI: 56.5-61.6). The seroprevalences for the 2 age groups that received the one-dose MMR vaccine, with reported coverage exceeding 95%, were 42.6% and 70.0%, respectively. The data on the incidence, MMR coverage, and seroprevalence in children younger than 6 years of age indicate that a two-dose MMR strategy should be considered. Mumps surveillance should be strengthened in children aged 6-11 and in those aged 12-17 because of their high contact rates and relatively low seroprevalences.
authors.affiliation: Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu province, 210009, China.
authors.forename: Yuanbao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu province, 210009, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu province, 210009, China.
authors.forename: Xiuying
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu province, 210009, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu province, 210009, China.
authors.forename: Peishan
authors.initials: P
authors.lastname: Lu
authors.affiliation: Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu province, 210009, China.
authors.forename: Fubao
authors.initials: F
authors.lastname: Ma
authors.affiliation: Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu province, 210009, China.
authors.forename: Minghao
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Biostatistics and Epidemiology, School of Public Health, Southeast University, Nanjing, Jiangsu province, 210009, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Biostatistics and Epidemiology, School of Public Health, Southeast University, Nanjing, Jiangsu province, 210009, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Min
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000276:immunology*; D009107:Mumps / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D009109:Mumps virus / Q000276:immunology; D016036:Seroepidemiologic Studies; D014611:Vaccination; D064166:Vaccine Potency; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D022542:Measles-Mumps-Rubella Vaccine