title: Gold-installed biostable nanocomplexes for tumor-targeted siRNA delivery in vivo.
abstract: The key issues, associated with nanocarriers for small interfering RNAs (siRNAs), are their poor stability and lack of tumor targetability in vivo. To address these issues, we developed gold-installed polyethyleneimine/siRNA complexes with a corona of PEGylated hyaluronic acid.
authors.affiliation: Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Suwon 440-746, Republic of Korea. jhpark1@skku.edu.
authors.forename: Roun
authors.initials: R
authors.lastname: Heo
authors.forename: Hong Yeol
authors.initials: HY
authors.lastname: Yoon
authors.forename: Hyewon
authors.initials: H
authors.lastname: Ko
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Shin
authors.forename: Jueun
authors.initials: J
authors.lastname: Jeon
authors.forename: Yee Soo
authors.initials: YS
authors.lastname: Chae
authors.forename: Young Mo
authors.initials: YM
authors.lastname: Kang
authors.forename: Dukjoon
authors.initials: D
authors.lastname: Kim
authors.forename: Doo Sung
authors.initials: DS
authors.lastname: Lee
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Park
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D041681:NIH 3T3 Cells; D009374:Neoplasms, Experimental / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry; D000066970:Protein Corona / Q000737:chemistry; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D000066970:Protein Corona; D034741:RNA, Small Interfering; D011092:Polyethylene Glycols; D006046:Gold; D011094:Polyethyleneimine; D006820:Hyaluronic Acid