title: Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling.
abstract: OBJECTIVE
  Recent advances in redox biology have emphasized the role of hydrogen peroxide (H2O2) in the modulation of signaling pathways and revealed that H2O2 plays a role in cellular remodeling in adults. Thus, an understanding of the mechanisms that control H2O2 levels in mature tissue would be of great interest.
  
  
  RESULTS
  We used a denervation strategy to demonstrate that sensory neurons are responsible for controlling H2O2 levels under normal conditions and after being lesioned. Moreover, we demonstrate that severed nerves respond to appendage amputation via the induction of Hedgehog signaling and that this signaling is responsible for H2O2 production in the wounded epidermis. Finally, we show that H2O2 and nerve growth are regulated via reciprocal action in adults.
  
  
  CONCLUSIONS
  These data support a new paradigm for the regulation of tissue homeostasis: H2O2 attracts nerves and nerves control H2O2 levels in a positive feedback loop. This finding suggests that the peripheral nerve redox environment could be a target for manipulating cell plasticity in adults.
authors.affiliation: 1 Centre Interdisciplinaire de Recherche en Biologie (CIRB) CNRS UMR 7241/INSERM U1050/Collège de France , Paris, France .|2 École Normale Supérieure, Institute of Biology at the Ecole Normale Supérieure (IBENS) , CNRS UMR8197, INSERM U1024, Paris, France .|3 PSL Research University , Paris, France .
authors.forename: Francesca
authors.initials: F
authors.lastname: Meda
authors.affiliation: 1 Centre Interdisciplinaire de Recherche en Biologie (CIRB) CNRS UMR 7241/INSERM U1050/Collège de France , Paris, France .|3 PSL Research University , Paris, France .
authors.forename: Carole
authors.initials: C
authors.lastname: Gauron
authors.affiliation: 1 Centre Interdisciplinaire de Recherche en Biologie (CIRB) CNRS UMR 7241/INSERM U1050/Collège de France , Paris, France .|3 PSL Research University , Paris, France .|4 Biology Department, Université Paris Diderot , Sorbonne Paris Cité, Paris Cedex 13, France .
authors.forename: Christine
authors.initials: C
authors.lastname: Rampon
authors.affiliation: 1 Centre Interdisciplinaire de Recherche en Biologie (CIRB) CNRS UMR 7241/INSERM U1050/Collège de France , Paris, France .|3 PSL Research University , Paris, France .
authors.forename: Jérémie
authors.initials: J
authors.lastname: Teillon
authors.affiliation: 1 Centre Interdisciplinaire de Recherche en Biologie (CIRB) CNRS UMR 7241/INSERM U1050/Collège de France , Paris, France .|2 École Normale Supérieure, Institute of Biology at the Ecole Normale Supérieure (IBENS) , CNRS UMR8197, INSERM U1024, Paris, France .|3 PSL Research University , Paris, France .
authors.forename: Michel
authors.initials: M
authors.lastname: Volovitch
authors.affiliation: 1 Centre Interdisciplinaire de Recherche en Biologie (CIRB) CNRS UMR 7241/INSERM U1050/Collège de France , Paris, France .|3 PSL Research University , Paris, France .|4 Biology Department, Université Paris Diderot , Sorbonne Paris Cité, Paris Cedex 13, France .
authors.forename: Sophie
authors.initials: S
authors.lastname: Vriz
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D053823:Hedgehog Proteins / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D012583:Schwann Cells / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D015027:Zebrafish
chemical_list: D053823:Hedgehog Proteins; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide