title: Uncovering the function of Disrupted in Schizophrenia 1 through interactions with the cAMP phosphodiesterase PDE4: Contributions of the Houslay lab to molecular psychiatry.
abstract: Nearly 10years ago the laboratory of Miles Houslay was part of a collaboration which identified and characterized the interaction between Disrupted in Schizophrenia 1 and phosphodiesterase type 4. This work has had significant impact on our thinking of psychiatric illness causation and the potential for therapeutics.
authors.affiliation: Astrazeneca Neuroscience iMED, 141, Portland St, Cambridge, MA 02139 USA. Electronic address: nick.brandon@azneuro.com.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Brandon
mesh_terms: D000242:Cyclic AMP / Q000378:metabolism; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011485:Protein Binding; D011570:Psychiatry
chemical_list: D009419:Nerve Tissue Proteins; D000242:Cyclic AMP; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4
keywords: DISC1; PDE4; Schizophrenia