title: XPC: Going where no DNA damage sensor has gone before.
abstract: XPC has long been considered instrumental in DNA damage recognition during global genome nucleotide excision repair (GG-NER). While this recognition is crucial for organismal health and survival, as XPC's recognition of lesions stimulates global genomic repair, more recent lines of research have uncovered many new non-canonical pathways in which XPC plays a role, such as base excision repair (BER), chromatin remodeling, cell signaling, proteolytic degradation, and cellular viability. Since the first discovery of its yeast homolog, Rad4, the involvement of XPC in cellular regulation has expanded considerably. Indeed, our understanding appears to barely scratch the surface of the incredible potential influence of XPC on maintaining proper cellular function. Here, we first review the canonical role of XPC in lesion recognition and then explore the new world of XPC function.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami Miller, School of Medicine Miami, FL 33136, United States.
authors.forename: Leah
authors.initials: L
authors.lastname: Nemzow
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami Miller, School of Medicine Miami, FL 33136, United States.
authors.forename: Abigail
authors.initials: A
authors.lastname: Lubin
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami Miller, School of Medicine Miami, FL 33136, United States.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami Miller, School of Medicine Miami, FL 33136, United States. Electronic address: fgong@med.miami.edu.
authors.forename: Feng
authors.initials: F
authors.lastname: Gong
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D011499:Protein Processing, Post-Translational; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; C493797:Rad4 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C086984:XPC protein, human; D004247:DNA
keywords: BER; DNA repair; GG-NER; Nucleotide excision repair; Rad4; XPC