title: Desmoplastic Melanoma Carries High Mutation Burden.
abstract: The first thorough sequencing of desmoplastic melanoma samples has shown that these tumors carry a median of 62 mutations per megabase-among the highest known for all cancers. The results suggest that patients may respond well to immunotherapy, which relies on detecting differences between normal and cancerous cells.
mesh_terms: D006579:Heterozygote; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics; D008545:Melanoma / Q000235:genetics* / Q000473:pathology*; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics
chemical_list: D020672:I-kappa B Proteins; C105627:NFKBIE protein, human; D011518:Proto-Oncogene Proteins