title: Regional Coherence Changes in Alzheimer's Disease Patients with Depressive Symptoms: A Resting-State Functional MRI Study.
abstract: Alzheimer's disease (AD) is characterized by progressive cognitive decline along with neuropsychiatric symptoms including depression and psychosis. Depression is a common psychiatric disorder occurring in people across the lifespan. Accumulating evidence indicates that depression may be a prodrome and/or a "risk factor" for AD. However, whether AD and depression share a common pathophysiological pathway is still unclear. The aim of this study was to identify regional alterations in brain function associated with depressive symptoms in mild AD patients. Thirty-two mild AD patients were evaluated using the Neuropsychiatric Inventory and Hamilton Depression Rating Scale, and were divided into two groups: 15 AD patients with depressive symptoms (D-AD) and 17 non-depressed AD (nD-AD) patients. Using the approach of regional homogeneity (ReHo), we characterized resting-state regional brain activity in D-AD and nD-AD patients. Compared with nD-AD patients, D-AD patients showed decreased ReHo in the right precentral gyrus, right superior frontal gyrus, right middle frontal gyrus, and right inferior frontal cortex. Our findings show regional brain activity alterations in D-AD patients. Thus, D-AD pathogenesis may be attributed to abnormal neural activity in multiple brain regions.
authors.affiliation: Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, and the Collaborative Innovation Center for Brain Science, Hangzhou, Zhejiang, China.|Tongde Hospital of Zhejiang Provence, Hangzhou, Zhejiang, China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Center for Cognitive Brain Disorders & Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, China.
authors.forename: Xiaozheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Center for Cognitive Brain Disorders & Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, China.
authors.forename: Xize
authors.initials: X
authors.lastname: Jia
authors.affiliation: Tongde Hospital of Zhejiang Provence, Hangzhou, Zhejiang, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Hou
authors.affiliation: Tongde Hospital of Zhejiang Provence, Hangzhou, Zhejiang, China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Tongde Hospital of Zhejiang Provence, Hangzhou, Zhejiang, China.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Wei
authors.affiliation: Tongde Hospital of Zhejiang Provence, Hangzhou, Zhejiang, China.
authors.forename: Jiapeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Tongde Hospital of Zhejiang Provence, Hangzhou, Zhejiang, China.
authors.forename: Xingli
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, and the Collaborative Innovation Center for Brain Science, Hangzhou, Zhejiang, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Yuedi
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, and the Collaborative Innovation Center for Brain Science, Hangzhou, Zhejiang, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, and the Collaborative Innovation Center for Brain Science, Hangzhou, Zhejiang, China.
authors.forename: Luoyi
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, and the Collaborative Innovation Center for Brain Science, Hangzhou, Zhejiang, China.|Key Laboratory of Medical Neurobiology of Chinese Ministry of Health, Hangzhou, Zhejiang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003863:Depression / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales; D012146:Rest
keywords: Alzheimer’s disease; depressive symptoms; regional homogeneity; resting state functional magnetic resonance imaging