title: Genetic Predisposition to Polycystic Ovary Syndrome, Postpartum Weight Reduction, and Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is a common condition in reproductive-aged women and a major female-specific risk factor of obesity, impaired glucose tolerance, and diabetes.
  
  
  OBJECTIVE
  We examined whether the genetic variation predisposing to PCOS affected glycemic changes in women with prior gestational diabetes mellitus (GDM) and whether such an effect was modified by changes in body adiposity, especially during and after pregnancy.
  
  
  METHODS
  This is a longitudinal study in Tianjin, China. We genotyped 7 genome-wide association study-identified PCOS single nucleotide polymorphisms and assessed gestational weight gain and changes in glycemic traits and weight at 1 to 5 years postpartum in 1133 women with prior GDM.
  
  
  METHODS
  The main outcome measure was postpartum glycemic changes.
  
  
  RESULTS
  The PCOS genetic risk score significantly interacted with postpartum weight reduction on changes in fasting glucose and 2-h glucose (P for interaction = .032 and .007; respectively) after multivariable adjustment. In women with postpartum weight reduction of ≥ 5 kg/y, the genetic risk score was associated with decreased fasting and 2-h glucose, whereas an opposite genetic effect was found in women who lost less weight. The association between postpartum weight reduction and glycemic improvement was more significant among women with a higher genetic risk score.
  
  
  CONCLUSIONS
  In a large cohort of Chinese women with a history of GDM, our data for the first time indicate that the genetic predisposition to PCOS may interact with postpartum weight reduction on long-term glycemic changes, emphasizing the importance of postpartum weight management in prevention of diabetes in this subgroup of women.
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Tiange
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Junhong
authors.initials: J
authors.lastname: Leng
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Aline
authors.initials: A
authors.lastname: Martins de Carvalho
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Weiqin
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Huikun
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Leishen
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
authors.affiliation: Department of Epidemiology (T.W., T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; Department of Nutrition (T.W., A.M.d.C., T.H., Y.Z., L.Q.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Shanghai Clinical Center for Endocrine and Metabolic Diseases (T.W.), Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Tianjin Women's and Children's Health Center (J.L., N.L., W.L., H.L., L.W.), Tianjin 300000, China; and Pennington Biomedical Research Center (G.H.), Baton Rouge, Louisiana 70808.
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015331:Cohort Studies; D053418:Death Domain Receptor Signaling Adaptor Proteins / Q000235:genetics; D016640:Diabetes, Gestational / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics; D006801:Humans; D008137:Longitudinal Studies; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D049590:Postpartum Period; D011247:Pregnancy; D012189:Retrospective Studies; D018570:Risk Assessment; D015430:Weight Gain / Q000502:physiology; D015431:Weight Loss / Q000235:genetics*
chemical_list: D001786:Blood Glucose; C571984:DENND1A protein, human; D053418:Death Domain Receptor Signaling Adaptor Proteins; D020662:Guanine Nucleotide Exchange Factors