title: Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer's disease: a novel diagnostic marker.
abstract: Alzheimer's disease (AD) is the primary cause of dementia in the elderly. The ectodomain of p75 neurotrophin receptor (p75NTR-ECD) has been suggested to play important roles in regulating beta-amyloid (Aβ) deposition and in protecting neurons from the toxicity of soluble Aβ. However, whether and how the serum and cerebrospinal fluid (CSF) levels of p75NTR-ECD change in patients with AD are not well documented. In the present study, we determined the concentrations of serum p75NTR-ECD in an AD group, a Parkinson disease group and a stroke group, as well as in a group of elderly controls without neurological disorders (EC). We also determined the levels of CSF p75NTR-ECD in a subset of the AD and EC groups. Our data showed that a distinct p75NTR-ECD profile characterized by a decreased CSF level and an increased serum level was present concomitantly with AD patients but not with other diseases. p75NTR-ECD levels in both the serum and CSF were strongly correlated with Mini-Mental State Examination (MMSE) scores and showed sound differential diagnostic value for AD. Moreover, when combining CSF Aβ42, CSF Aβ42/40, CSF ptau181 or CSF ptau181/Aβ42 with CSF p75NTR-ECD, the area under the receiver operating characteristic curve (AUC) and diagnostic accuracies improved. These findings indicate that p75NTR-ECD can serve as a specific biomarker for AD and the determination of serum and CSF p75NTR-ECD levels is likely to be helpful in monitoring AD progression.
authors.affiliation: Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: S-S
authors.initials: SS
authors.lastname: Jiao
authors.affiliation: Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: X-L
authors.initials: XL
authors.lastname: Bu
authors.affiliation: Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Y-H
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Q-H
authors.initials: QH
authors.lastname: Wang
authors.affiliation: Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: C-H
authors.initials: CH
authors.lastname: Liu
authors.affiliation: Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Yao
authors.affiliation: Division of Health Sciences, School of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, SA, Australia.
authors.forename: X-F
authors.initials: XF
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D015703:Antigens, CD / Q000097:blood / Q000134:cerebrospinal fluid; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D003937:Diagnosis, Differential; D061827:Dimensional Measurement Accuracy; D018450:Disease Progression; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood / Q000134:cerebrospinal fluid; D000066829:Neuroprotection / Q000502:physiology; D010300:Parkinson Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis; D010446:Peptide Fragments / Q000378:metabolism*; D011237:Predictive Value of Tests; D017475:Receptors, Nerve Growth Factor / Q000097:blood; D013223:Statistics as Topic; D020521:Stroke / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis
chemical_list: D016229:Amyloid beta-Peptides; D015703:Antigens, CD; D015415:Biomarkers; C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D017475:Receptors, Nerve Growth Factor; C078639:amyloid beta-protein (1-38)