title: Polystyrene Nanofiber Materials for Visible-Light-Driven Dual Antibacterial Action via Simultaneous Photogeneration of NO and O2((1)Δg).
abstract: This contribution reports on the preparation, characterization, and biological evaluation of electrospun polystyrene nanofiber materials engineered with a covalently grafted NO photodonor and ionically entangled tetracationic porphyrin and phthalocyanine photosensitizers. These photofunctional materials exhibit an effective and simultaneous photogeneration of two antibacterial species such as nitric oxide (NO) and singlet oxygen, O2((1)Δg) under illumination with visible light, as demonstrated by their direct detection using amperometric and time-resolved spectroscopic techniques. Dual-mode photoantibacterial action is demonstrated by antibacterial tests carried out on Escherichia coli.
authors.affiliation: Faculty of Science, Charles University in Prague , 2030 Hlavova, 128 43 Prague 2, Czech Republic.|Institute of Inorganic Chemistry, v.v.i., Czech Academy of Sciences , 250 68 Řež, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Dolanský
authors.affiliation: Faculty of Science, Charles University in Prague , 2030 Hlavova, 128 43 Prague 2, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Henke
authors.affiliation: J. Heyrovský Institute of Physical Chemistry, v.v.i., Czech Academy of Sciences , Dolejškova 3, 182 23 Prague 8, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Kubát
authors.affiliation: Laboratory of Photochemistry, Department of Drug Sciences, University of Catania , Viale Andrea Doria 6, I-95125 Catania, Italy.
authors.forename: Aurore
authors.initials: A
authors.lastname: Fraix
authors.affiliation: Laboratory of Photochemistry, Department of Drug Sciences, University of Catania , Viale Andrea Doria 6, I-95125 Catania, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sortino
authors.affiliation: Faculty of Science, Charles University in Prague , 2030 Hlavova, 128 43 Prague 2, Czech Republic.|Institute of Inorganic Chemistry, v.v.i., Czech Academy of Sciences , 250 68 Řež, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Mosinger
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D055664:Electrochemical Techniques; D005453:Fluorescence; D007474:Ion Exchange; D008027:Light; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D009569:Nitric Oxide / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D011137:Polystyrenes; D012996:Solutions; D009569:Nitric Oxide; D010100:Oxygen
keywords: antibacterial; nanofiber; nitric oxide; photogeneration; singlet oxygen