title: Classic PCOS phenotype is not associated with deficiency of endogenous vitamin D and VDR gene polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs1544410 (BsmI), rs10735810 (FokI): a case-control study of lower Silesian women.
abstract: BACKGROUND
  The role of endogenous vitamin D and vitamin D receptor (VDR) gene polymorphism in polycystic ovary syndrome (PCOS) is still controversial.
  
  
  OBJECTIVE
  The objective of this study was to investigate for the first time in women with "classic" PCOS phenotype and healthy controls the role of the serum endogenous vitamin D level and VDR gene polymorphisms in PCOS etiology.
  
  
  METHODS
  Ninety-two women with "classic" PCOS phenotype and 85 controls from lower Silesia with comparable body mass index (BMI) were studied. In all women the waist circumference, android/gynoid fat deposit, parameters of lipid and glucose metabolism, testosterone, free androgen index, sex hormone binding globulin (SHBG) and vitamin D were evaluated. Also, VDR gene polymorphisms rs731236, rs7975232, rs1544410 and rs10735810 were assessed.
  
  
  RESULTS
  Serum vitamin D levels in both groups were comparable. Also high, comparable frequencies of hypovitaminosis and vitamin D deficiency in both groups were observed. Women with "classic" PCOS phenotype had statistically significantly higher values of all measured parameters, except serum SHBG and high-density lipoprotein (HDL)-cholesterol, which were lower. The frequency of VDR genotype polymorphism was also comparable in both groups.
  
  
  CONCLUSIONS
  For the first time, we show that endogenous vitamin D deficiency and VDR polymorphisms are not associated with homogeneous "classic" PCOS phenotype.
authors.affiliation: a Department and Clinic of Endocrinology , Diabetology and Isotope Treatment .
authors.forename: Diana
authors.initials: D
authors.lastname: Jedrzejuk
authors.affiliation: a Department and Clinic of Endocrinology , Diabetology and Isotope Treatment .
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Łaczmański
authors.affiliation: a Department and Clinic of Endocrinology , Diabetology and Isotope Treatment .
authors.forename: Andrzej
authors.initials: A
authors.lastname: Milewicz
authors.affiliation: a Department and Clinic of Endocrinology , Diabetology and Isotope Treatment .
authors.forename: Justyna
authors.initials: J
authors.lastname: Kuliczkowska-Płaksej
authors.affiliation: a Department and Clinic of Endocrinology , Diabetology and Isotope Treatment .
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Lenarcik-Kabza
authors.affiliation: b Department and Clinic of Gynecology and Obstetrics , and.
authors.forename: Lidia
authors.initials: L
authors.lastname: Hirnle
authors.affiliation: c Department of Radiology , Wroclaw Medical University , Wroclaw , Poland , and.
authors.forename: Urszula
authors.initials: U
authors.lastname: Zaleska-Dorobisz
authors.affiliation: d Department of Health Promotion , Faculty of Physiotherapy, University School of Physical Education , Wroclaw , Poland.
authors.forename: Felicja
authors.initials: F
authors.lastname: Lwow
mesh_terms: D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D010641:Phenotype; D011044:Poland; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL; D018167:Receptors, Calcitriol; D012738:Sex Hormone-Binding Globulin; D014807:Vitamin D
keywords: PCOS; VDR; VDR polymorphism; vitamin D