title: The impact of oral anticoagulation on time to surgery in patients hospitalized with hip fracture.
abstract: BACKGROUND
  Current clinical guidelines recommend expedited repair of hip fracture to reduce morbidity and mortality. A significant number of hip fracture patients have concomitant cardiovascular disease requiring anticoagulation. Vitamin K antagonists (VKAs), which have been traditionally used, might be associated with an increased time to surgery (TTS) and it remains unknown what effect direct oral anticoagulants (DOACs) have on this metric. Our objective is to determine how anticoagulation with a VKA or DOAC affects TTS.
  
  
  METHODS
  This is a case control study comparing TTS in consecutively admitted hip fracture patients receiving either a DOAC or VKA with age- and gender-matched controls between January 1, 2010 and March 24, 2014. The primary end point is TTS, which is defined as the time elapsed from admission to surgery. Secondary end points include the rate of stroke, death, bleeding and VTE during admission.
  
  
  RESULTS
  Of 2258 patients, 233 were on a VKA while 27 were on a DOAC. Median TTS seems to be longer in patients receiving a DOAC or a VKA when compared to controls. (40 h vs. 26.2h). The DOAC group tended to have longer median TTS when compared to the VKA groups (66.9h vs. 39.4h) There was no difference in the rate of stroke, death, bleeding and VTE during admission.
  
  
  CONCLUSIONS
  Patients on anticoagulation prior to admission for hip fracture experienced longer delays in surgery when compared to patients not receiving anticoagulation. Patients on a DOAC experienced the longest surgical delay.
authors.affiliation: Department of Medicine, University of Ottawa at The Ottawa Hospital, 501 Smyth Road, Box 201A, Ottawa, Ontario K1H 8L6, Canada. Electronic address: ttran@toh.on.ca.
authors.forename: Thomas
authors.initials: T
authors.lastname: Tran
authors.affiliation: Département de Médecine Interne, Brest University Hospital, EA3878, bd Tanguy Prigent, 29609 Brest Cedex Brest, France. Electronic address: aurelien.delluc@chu-brest.fr.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Delluc
authors.affiliation: The Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada. Electronic address: cdewit@toh.on.ca.
authors.forename: Carine
authors.initials: C
authors.lastname: de Wit
authors.affiliation: The Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada. Electronic address: wpetrcich@ohri.ca.
authors.forename: William
authors.initials: W
authors.lastname: Petrcich
authors.affiliation: Department of Medicine, University of Ottawa at The Ottawa Hospital, 501 Smyth Road, Box 201A, Ottawa, Ontario K1H 8L6, Canada; Département de Médecine Interne, Brest University Hospital, EA3878, bd Tanguy Prigent, 29609 Brest Cedex Brest, France; The Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada. Electronic address: glegal@toh.on.ca.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Le Gal
authors.affiliation: Department of Medicine, University of Ottawa at The Ottawa Hospital, 501 Smyth Road, Box 201A, Ottawa, Ontario K1H 8L6, Canada; The Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada. Electronic address: mcarrier@toh.on.ca.
authors.forename: Marc
authors.initials: M
authors.lastname: Carrier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D006620:Hip Fractures / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000925:Anticoagulants
keywords: Anticoagulants; Arthroplasty; Hip fractures; Surgery; Warfarin