title: Releasing the Brake on IFN-γ Signaling on Infection.
abstract: Toxoplasma gondii effectively inhibits the responsiveness of its host cell to interferon gamma (IFN-γ). Using a genome-wide genetic screen, Beiting and colleagues have recently identified coactivators of the transcription factor STAT1 that can diminish this inhibitory effect. One of these coactivators, TLX, enhances type 1 helper (Th1) immune responses and restricts parasite replication during chronic toxoplasmosis.
authors.affiliation: Institute for Medical Microbiology, Georg August University, Göttingen, Germany. Electronic address: clueder@gwdg.de.
authors.forename: Carsten G K
authors.initials: CGK
authors.lastname: Lüder
authors.affiliation: Institute for Medical Microbiology, Georg August University, Göttingen, Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Sumpf
authors.affiliation: Institute for Medical Microbiology, Georg August University, Göttingen, Germany.
authors.forename: Roswitha
authors.initials: R
authors.lastname: Nast
mesh_terms: D000818:Animals; D055106:Genome-Wide Association Study; D006790:Host-Parasite Interactions / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology / Q000469:parasitology; D014122:Toxoplasma / Q000276:immunology; D014123:Toxoplasmosis / Q000276:immunology*
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D050794:STAT1 Transcription Factor; D007371:Interferon-gamma
keywords: IFN-γ; STAT1; TLX; Toxoplasma gondii; parasite–host interaction; transcription