title: A fatal case of primary cardiac chondrosarcoma presenting with amaurosis fugax.
abstract: A 64-year-old previously healthy woman consulted her general practitioner because of recurrent episodes of right-sided monocular transient visual loss (ie, amaurosis fugax). At first, these symptoms were followed over time, but as the attacks worsened, and were accompanied by dizziness and general discomfort, the patient was admitted to the department of neurology for further investigations. CT of the brain was normal; however, during admission, the patient developed rapid atrial fibrillation and was transferred to the department of cardiology. Transthoracic echocardiography revealed a massive tumour on the atrial side of the anterior mitral valve leaflet, partly obstructing the mitral valve inflow. The tumour was excised and a biological prosthetic mitral valve inserted. The tumour was histologically determined to be a highly malignant dedifferentiated chondrosarcoma. After 6 months, the tumour relapsed and expanded aggressively to completely obstruct the mitral valve inflow, ultimately leading to cardiac arrest and death.
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Sundbøll
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.
authors.forename: Nils Henrik Stubkjær
authors.initials: NH
authors.lastname: Hansson
authors.affiliation: Department of Pathology, Aarhus University Hospital, Aarhus C, Denmark.
authors.forename: Steen
authors.initials: S
authors.lastname: Baerentzen
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark Cardiovascular and Metabolic Preventive Clinic, Department of Endocrinology, Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense, Denmark.
authors.forename: Manan
authors.identifier: http://orcid.org/0000-0002-0867-5825
authors.initials: M
authors.lastname: Pareek
mesh_terms: D020757:Amaurosis Fugax / Q000209:etiology*; D001281:Atrial Fibrillation / Q000209:etiology; D002813:Chondrosarcoma / Q000473:pathology* / Q000601:surgery*; D004452:Echocardiography; D017809:Fatal Outcome; D005260:Female; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed