title: Silver and other metals in the treatment of gastrointestinal diseases.
abstract: Disturbance in the functioning of the gastrointestinal (GI) tract can critically affect the health and even the life of the whole organism. Several factors, both exo- and endogenous may contribute to the dysregulation of homeostasis in the digestive system, including genetic background, ingestion of highly processed food, exposition to environmental pollution or chronic stress, and changes in gut microflora, to name just a few. An important number of these factors rely on metals, which often play a dual, stimulatory and inhibitory role in crucial physiological processes. In this paper, we focus on the structures incorporating silver, copper and other metals as future drugs against GI diseases. We critically review available literature for their effectiveness and potential application, and discuss clinical relevance of these findings.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Siczek
authors.forename: Hubert
authors.initials: H
authors.lastname: Zatorski
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland and Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. jakub.fichna@umed.lodz.pl.
authors.forename: Jakub
authors.initials: J
authors.lastname: Fichna
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000639:trends; D056831:Coordination Complexes / Q000627:therapeutic use*; D003300:Copper / Q000737:chemistry; D005767:Gastrointestinal Diseases / Q000145:classification / Q000188:drug therapy*; D006801:Humans; D012834:Silver / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D056831:Coordination Complexes; D012834:Silver; D003300:Copper