title: KDM3A interacted with p53K372me1 and regulated p53 binding to PUMA in gastric cancer.
abstract: Chemoresistance remains a major problem in the treatment of gastric cancer patients, leading to the serious limitation of efficacy of chemotherapeutic regime. However, the underlying mechanism remains largely unknown. In our present study, we for the first time found that knock down of KDM3A can promote apoptosis induced by chemoreagent Cisplatin and Paclitaxel through p53. Mechanistically, through promoting p53 binding to the promoter of PUMA. However, knock down of KDM3A as such doesn't affect p53 level. In addition, KDM3A can interact with p53K372me1 in protein-protein interaction fashion, leading to the inactivation of p53, may eventually leading to chemoresistance of gastric cancer.
authors.affiliation: The Department of Gastrointestinal and Anus Surgery, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan 364000, Fujian Province, PR China.
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Li
authors.affiliation: The Department of Gastrointestinal and Anus Surgery, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan 364000, Fujian Province, PR China.
authors.forename: Shuangming
authors.initials: S
authors.lastname: Lin
authors.affiliation: The Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, PR China.
authors.forename: Wenhuan
authors.initials: W
authors.lastname: Li
authors.affiliation: The Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, PR China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Wang
authors.affiliation: The Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, PR China. Electronic address: ncdxyfy_xuemingli@163.com.
authors.forename: Xueming
authors.initials: X
authors.lastname: Li
authors.affiliation: The Department of Gastrointestinal and Anus Surgery, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan 364000, Fujian Province, PR China. Electronic address: fmualfh_dbxu@163.com.
authors.forename: Dongbo
authors.initials: D
authors.lastname: Xu
keywords: Chemoresistance; Gastric cancer; KDM3A; p53; p53K372me1