title: JBP485 promotes corneal epithelial wound healing.
abstract: Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In the present study, it was found that placental extract-derived dipeptide (JBP485) significantly increased the proliferation and migration of corneal epithelial cells (CECs). Moreover, JBP485 accelerated corneal epithelial wound healing in vivo without inflammation and neovascularization and was found to be effective for the treatment of corneal damage. These data indicate that JBP485 efficiently activates the viability of CECs and has potential as a novel treatment for various kinds of corneal epithelial disease.
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Maho
authors.initials: M
authors.lastname: Nagata
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.|Research Center for Inflammation and Regenerative Medicine, Doshisha University, Kyoto, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Yuiko
authors.initials: Y
authors.lastname: Hata
authors.affiliation: Japan Bio Products Co., Ltd., 1-44-4, Tomigaya, Shibuya-ku, Tokyo 151-0063, Japan.
authors.forename: Shumpei
authors.initials: S
authors.lastname: Yamaguchi
authors.affiliation: Japan Bio Products Co., Ltd., 1-44-4, Tomigaya, Shibuya-ku, Tokyo 151-0063, Japan.
authors.forename: Taiichi
authors.initials: T
authors.lastname: Kaku
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kinoshita
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D019573:Epithelium, Corneal / Q000187:drug effects* / Q000473:pathology*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
chemical_list: C412308:JBP 485; D010456:Peptides, Cyclic