title: Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication.
abstract: Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial for understanding the sequential changes involving malignant transformation, tumor progression, and advanced or disseminated cancer stages. Moreover, we focus on the cellular localization of this proteoglycan as cell membrane anchored and/or shed, soluble syndecan-1 with stromal or nuclear accumulation and how this may carry different, highly tissue specific prognostic information for individual tumor types.
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, F-46, 141 86 Stockholm, Sweden.
authors.forename: Tünde
authors.initials: T
authors.lastname: Szatmári
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, F-46, 141 86 Stockholm, Sweden.
authors.forename: Rita
authors.initials: R
authors.lastname: Ötvös
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, F-46, 141 86 Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Hjerpe
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, F-46, 141 86 Stockholm, Sweden.
authors.forename: Katalin
authors.initials: K
authors.lastname: Dobra
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D015398:Signal Transduction; D053668:Syndecan-1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D053668:Syndecan-1