title: Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines.
abstract: Rationally designed subunit vaccines mainly consist of small peptides or B-cell epitopes, which can stimulate the body's immune response. Development of subunit vaccines is a very tedious and costly process. One of the imperative and crucial steps of vaccine development is the identification of highly competent B-cell epitopes as most of the proteins and fragments of proteins are immunologically irrelevant. With the advances in bioinformatics tools, it can be possible to precisely narrow down potential B-cell epitopes from the whole proteome of any pathogen. This chapter sheds light on prediction and designing of B-cell epitopes using two in silico tools LBtope and IgPred.
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Sector-39A, Chandigarh, 160036, India.
authors.forename: Harinder
authors.initials: H
authors.lastname: Singh
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Sector-39A, Chandigarh, 160036, India.
authors.forename: Sudheer
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Sector-39A, Chandigarh, 160036, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Gautam
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Sector-39A, Chandigarh, 160036, India. raghava@imtech.res.in.
authors.forename: Gajendra P S
authors.initials: GP
authors.lastname: Raghava
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D000906:Antibodies / Q000276:immunology; D000918:Antibody Specificity / Q000276:immunology; D000941:Antigens / Q000737:chemistry / Q000276:immunology; D018604:Epitope Mapping / Q000379:methods; D018985:Epitopes, B-Lymphocyte / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D015203:Reproducibility of Results; D022223:Vaccines, Subunit / Q000737:chemistry / Q000276:immunology*
chemical_list: D000906:Antibodies; D000941:Antigens; D018985:Epitopes, B-Lymphocyte; D010455:Peptides; D022223:Vaccines, Subunit
keywords: B-cell epitopes; Bioinformatics; IgPred; In silico; LBtope; Vaccine