title: The Valuable Role of Measuring Serum Lipid Profile in Cancer Progression.
abstract: OBJECTIVE
  Serum lipid levels are not only associated with etiology, but also with prognosis in cancer. To investigate this issue further, we aimed to evaluate the serum levels of lipids in association with the most important prognostic indicators in cancer patients at the start of chemotherapy.
  
  
  METHODS
  In a retrospective cross-sectional study, using existing medical records obtained from 2009-2014, the data of all incident cancer cases in Iranian patients referred to the Semnan oncology clinic for chemotherapy were analyzed. Data on demographics, cancer type, prognostic indicators (e.g. lymph node involvement, metastasis, and stage of disease), as well as the patient's lipid profile were collected. We used multiple logistic regression models to show the relationship between prognosis indicators and lipid profile adjusting for age, gender, and type of cancer.
  
  
  RESULTS
  The data of 205 patients was gathered. We found a significant difference in the lipid profile between different types of cancers (breast, colon, gastric, and ovarian). With the exception of high-density lipoprotein levels in women, which were higher than in men, the means of other lipid profiles were similar between the genders. There was a significant association between higher levels of low-density lipoprotein (LDL >110mg/dL) in the serum and metastasis (adjusted odds ratio=2.4, 95% CI 1.2-3.5). No significant association was reported between lipid profile and lymph nodes involvement and stage of the disease.
  
  
  CONCLUSIONS
  Our study suggested a benefit of measuring serum levels of lipids for predicting cancer progression. Increased LDL levels can be considered a predictive factor for increasing the risk of metastasis.
authors.affiliation: Internal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Ghahremanfard
authors.affiliation: Research Center for Social Determinants of Health, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Mirmohammadkhani
authors.affiliation: Internal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Banafsheh
authors.initials: B
authors.lastname: Shahnazari
authors.affiliation: Internal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Golnaz
authors.initials: G
authors.lastname: Gholami
authors.affiliation: Language Group, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Jamileh
authors.initials: J
authors.lastname: Mehdizadeh
keywords: Cancer; Disease Progression; Lipids; Metastasis