title: High-mix insulins.
abstract: Premix insulins are commonly used insulin preparations, which are available in varying ratios of different molecules. These drugs contain one short- or rapid-acting, and one intermediate- or long-acting insulin. High-mix insulins are mixtures of insulins that contain 50% or more than 50% of short-acting insulin. This review describes the clinical pharmacology of high-mix insulins, including data from randomized controlled trials. It suggests various ways, in which high-mix insulin can be used, including once daily, twice daily, thrice daily, hetero-mix, and reverse regimes. The authors provide a rational framework to help diabetes care professionals, identify indications for pragmatic high-mix use.
authors.affiliation: Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kalra
authors.affiliation: Dubai Diabetes Center, Dubai Health Authority, Dubai, United Arab Emirates.
authors.forename: Mohammad Hamed
authors.initials: MH
authors.lastname: Farooqi
authors.affiliation: Tawam Medical Campus, Johns Hopkins Medicine, Dubai, United Arab Emirates ; Faculty of Medicine, UAE University, Al Ain, Abu Dhabi, United Arab Emirates.
authors.forename: Ali E
authors.initials: AE
authors.lastname: El-Houni
keywords: Aspart; biphasic aspart; biphasic insulin; co-formulations; lispro; lispro mix; premix insulin