title: Timing of Gonadectomy in Patients with Complete Androgen Insensitivity Syndrome-Current Recommendations and Future Directions.
abstract: This review highlights the controversy regarding timing of gonadectomy in patients with complete androgen insensitivity syndrome (CAIS). We will review the published literature regarding frequency of gonadal malignancy and summarize historical findings. Recent research suggests that gonadectomy may be deferred until adulthood due to the low risk of malignancy. An algorithm is also provided to help guide clinicians in management of patients with complete androgen insensitivity syndrome who have deferred gonadectomy.
authors.affiliation: Department of Obstetrics and Gynecology, Christiana Care Health Services, Newark, Delaware. Electronic address: Vrunda.Patel@medstar.net.
authors.forename: Vrunda
authors.initials: V
authors.lastname: Patel
authors.affiliation: Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, MedStar Washington Hospital Center/Children's National Medical Center, Washington, DC.
authors.forename: Rachel Kastl
authors.initials: RK
authors.lastname: Casey
authors.affiliation: Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, MedStar Washington Hospital Center/Children's National Medical Center, Washington, DC.
authors.forename: Veronica
authors.initials: V
authors.lastname: Gomez-Lobo
mesh_terms: D000465:Algorithms; D013734:Androgen-Insensitivity Syndrome / Q000601:surgery*; D002369:Castration / Q000379:methods*; D000066491:Clinical Decision-Making / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D061665:Time-to-Treatment
keywords: Complete androgen insensitivity syndrome; Gonadectomy; Testicular feminization syndrome