title: Chloroquine retinopathy: pattern of presentation in Ibadan, Sub-Sahara Africa.
abstract: BackgroundSelf-medication with chloroquine is common in Ibadan, Sub-Sahara Africa. Retinopathy from chloroquine is not uncommon. The aim was to determine the pattern of presentation.MethodologyCases of Chloroquine retinopathy seen at the Retina and Vitreous Unit of the University College Hospital, Ibadan between 2008 and 2014 were reviewed. Information on age, sex, duration of chloroquine use, and visual loss were retrieved. Visual acuity at presentation, anterior, and posterior segment findings were documented. The results were analyzed using proportions and percentages.ResultsFourteen cases were seen during the study period. Mean age was 50.7 years. Male to female ratio was 3.5 : 1. Average duration of visual loss before presentation was 2.7 years. Average duration of self-medication with chloroquine was 5.3 years. Presenting visual acuity showed 2(14%) cases of bilateral blindness(VA<3/60 in both eyes); 5(35.7%) cases of uniocular blindness; three cases of bilateral low vision(VA worse than 6/18 but better than 3/60). Anterior segment examination showed abnormal sluggish pupillary reaction in those with severe affectation. Dilated fundoscopy showed features ranging from mild macular pigmentary changes and bulls eye maculopathy to overt extensive retinal degeneration involving the posterior pole, attenuation of retinal vessels, optic atrophy, and beaten bronze appearance of atrophic maculopathy.ConclusionChloroquine retinopathy is not uncommon in Ibadan, Sub-Sahara Africa. Bulls eye maculopathy, extensive retinal, and macular degeneration with optic atrophy are the main presentations. Public health education is imperative.
authors.affiliation: Retina and Vitreous Unit, Department of Ophthalmology, University College Hospital, Ibadan, Nigeria.
authors.forename: T S
authors.initials: TS
authors.lastname: Oluleye
authors.affiliation: Retina and Vitreous Unit, Department of Ophthalmology, University College Hospital, Ibadan, Nigeria.
authors.forename: Y
authors.initials: Y
authors.lastname: Babalola
authors.affiliation: Retina and Vitreous Unit, Department of Ophthalmology, University College Hospital, Ibadan, Nigeria.
authors.forename: M
authors.initials: M
authors.lastname: Ijaduola
mesh_terms: D000328:Adult; D000368:Aged; D000962:Antimalarials; D002738:Chloroquine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D012160:Retina / Q000187:drug effects*; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D012651:Self Medication / Q000009:adverse effects*; D014792:Visual Acuity
chemical_list: D000962:Antimalarials; D002738:Chloroquine