title: Early start renal replacement therapy for acute kidney injury-Universal panacea or another case of over medicalization?
abstract: Despite advances in medical practice and renal replacement therapy, the mortality of patients who develop acute kidney injury remains high. In the field of cardiology, the management of myocardial infarction has evolved from one of conservative bed rest to primary coronary intervention. As renal replacement therapy is now generally available, the question arises whether earlier intervention could lead to improved patient outcomes. The evidence to date is primarily centered on retrospective observational reports, with the majority reporting increased patient survival for earlier intervention. However, these reports are typically based on small numbers of patients and differ in the etiology of acute kidney injury, patient comorbidity, and definitions of what constitutes "early" start. To date, there is less than a handful of prospective randomized studies published in the modern era. Again these are small studies, with differing patient populations, and definitions of "early" start, but generally do not show any significant advantage for an "early" start approach. As such until adequately powered prospective trial data become available, the decision to initiate renal replacement therapy should be made by the traditional review of patient history, repeated clinical assessments, and trends in biochemical data.
authors.affiliation: UCL Center for Nephrology, Royal Free Hospital, University College London Medical School, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Davenport
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D015897:Comorbidity; D006801:Humans; D062528:Medicalization / Q000379:methods*; D006435:Renal Dialysis / Q000379:methods*; D017582:Renal Replacement Therapy / Q000009:adverse effects / Q000379:methods*
keywords: Dialysis; acute kidney injury; complications; renal replacement therapy