title: Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences.
abstract: Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consent to undergo Na(18)F(-) PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curve eliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions were compared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal) bone, and muscle. The SUV m (t) (m = max, mean) and a series of slopes were computed as (SUV m (t i ) - SUV m (t j ))/(t i - t j ), for pairs of time values t i and t j . A Patlak-like analysis was performed for the same time values by computing ((VOI p (t i )/VOI e (t i ))-(VOI p (t j )/VOI e (t j )))/(t i - t j ), where p = broken bone, other bone, and muscle and e = expected activity in a VOI. Paired comparisons between Patlak-like and SUV m slopes showed good agreement by both linear regression and correlation coefficient analysis (r = 84%, r s = 78%-SUVmax, r = 92%, and r s = 91%-SUVmean), suggesting static scans could substitute for dynamic studies. Patlak-like slope differences of 0.1 min(-1) or greater between examinations and SUVmax differences of ~5 usually indicated good remodeling progress, while negative Patlak-like slope differences of -0.06 min(-1) usually indicated poor remodeling progress in this cohort.
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Lundblad
authors.affiliation: School of Information and Communication Technology, KTH Royal Institute of Technology, 16440 Stockholm, Sweden.
authors.forename: Gerald Q
authors.initials: GQ
authors.lastname: Maguire
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Karlsson-Thur
authors.affiliation: Department of Hospital Physics, Karolinska University Hospital Solna, 17176 Stockholm, Sweden.
authors.forename: Cathrine
authors.initials: C
authors.lastname: Jonsson
authors.affiliation: Department of Radiology, New York University, New York, NY 10016, USA.
authors.forename: Marilyn E
authors.initials: ME
authors.lastname: Noz
authors.affiliation: School of Computing, College of Engineering, University of Utah, Salt Lake City, UT 84109, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Zeleznik
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.
authors.forename: Hans
authors.initials: H
authors.lastname: Jacobsson
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Weidenhielm
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016723:Bone Remodeling; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D049268:Positron-Emission Tomography; D013977:Tibia / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D055815:Young Adult