title: Cancer screening via infrared spectral cytopathology (SCP): results for the upper respiratory and digestive tracts.
abstract: Instrumental advances in infrared micro-spectroscopy have made possible the observation of individual human cells and even subcellular structures. The observed spectra represent a snapshot of the biochemical composition of a cell; this composition varies subtly but reproducibly with cellular effects such as progression through the cell cycle, cell maturation and differentiation, and disease. The aim of this summary is to provide a synopsis of the progress achieved in infrared spectral cytopathology (SCP) - the combination of infrared micro-spectroscopy and multivariate methods of analysis - for the detection of abnormalities in exfoliated human cells of the upper respiratory and digestive tract, namely the oral and nasopharyngeal cavities, and the esophagus.
authors.affiliation: Laboratory for Spectral Diagnosis (LSpD), Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA and Cireca Theranostics, LLC, 19 Blackstone St, Cambridge, MA 02139, USA. m.diem@neu.edu.
authors.forename: Max
authors.initials: M
authors.lastname: Diem
authors.affiliation: Laboratory for Spectral Diagnosis (LSpD), Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
authors.forename: Miloš
authors.initials: M
authors.lastname: Miljković
authors.affiliation: Laboratory for Spectral Diagnosis (LSpD), Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bird
authors.affiliation: Laboratory for Spectral Diagnosis (LSpD), Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
authors.forename: Antonella I
authors.initials: AI
authors.lastname: Mazur
authors.affiliation: Laboratory for Spectral Diagnosis (LSpD), Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
authors.forename: Jen M
authors.initials: JM
authors.lastname: Schubert
authors.affiliation: Laboratory for Spectral Diagnosis (LSpD), Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Townsend
authors.affiliation: Department of Pathology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.
authors.forename: Nora
authors.initials: N
authors.lastname: Laver
authors.affiliation: Biophotonics Research Unit, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, UK.
authors.forename: Max
authors.initials: M
authors.lastname: Almond
authors.affiliation: Biophotonics Research Unit, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, UK.
authors.forename: Oliver
authors.initials: O
authors.lastname: Old
mesh_terms: D004847:Epithelial Cells / Q000473:pathology; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology*; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D013055:Spectrophotometry, Infrared / Q000379:methods*