title: A Low Noise Amplifier for Neural Spike Recording Interfaces.
abstract: This paper presents a Low Noise Amplifier (LNA) for neural spike recording applications. The proposed topology, based on a capacitive feedback network using a two-stage OTA, efficiently solves the triple trade-off between power, area and noise. Additionally, this work introduces a novel transistor-level synthesis methodology for LNAs tailored for the minimization of their noise efficiency factor under area and noise constraints. The proposed LNA has been implemented in a 130 nm CMOS technology and occupies 0.053 mm-sq. Experimental results show that the LNA offers a noise efficiency factor of 2.16 and an input referred noise of 3.8 μVrms for 1.2 V power supply. It provides a gain of 46 dB over a nominal bandwidth of 192 Hz-7.4 kHz and consumes 1.92 μW. The performance of the proposed LNA has been validated through in vivo experiments with animal models.
authors.affiliation: Institute of Microelectronics of Seville, Avda. Americo Vespucio s/n, Sevilla 41092, Spain. ruiz@imse-cnm.csic.es.
authors.forename: Jesus
authors.initials: J
authors.lastname: Ruiz-Amaya
authors.affiliation: Institute of Microelectronics of Seville, Avda. Americo Vespucio s/n, Sevilla 41092, Spain. alberto@imse-cnm.csic.es.
authors.forename: Alberto
authors.initials: A
authors.lastname: Rodriguez-Perez
authors.affiliation: Institute of Microelectronics of Seville, Avda. Americo Vespucio s/n, Sevilla 41092, Spain. mandel@imse-cnm.csic.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Delgado-Restituto
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000669:Amplifiers, Electronic; D015374:Biosensing Techniques / Q000295:instrumentation; D001931:Brain Mapping / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D005246:Feedback; D057230:Limit of Detection; D009474:Neurons / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio
keywords: Low-Noise Amplifier; biomedical circuit; circuit sizing; neural spike recording