title: Therapeutic efficacy of a polysaccharide isolated from Cordyceps sinensis on hypertensive rats.
abstract: This study was aimed to investigate the antihypertensive effect of a polysaccharide fraction from Cordyceps sinensis on spontaneously hypertensive rats (SHR). The CSP1, one component of Cordyceps sinensis polysaccharides (CSP), was obtained after water extraction, deproteinization, de-colorization and purification with DEAE-cellulose 52. And a more homogeneous component CSP1-2 was obtained using Sepharose CL-6B chromatography. CSP1-2 mainly consisted of mannose, glucose and galactose in a molar ratio of about 2:2:1 and its average molecular weight was approximately 2.70×10(4)Da. Pharmacological tests showed that CSP1, in which the CSP1-2 was its main component, had antihypertensive effect by stimulating the secretion of vasodilator NO, decreasing the level of ET-1, epinephrine, noradrenaline and angiotensin II, inhibiting the increase of transforming growth factor β1 (TGF-β1) and lowering the level of inflammatory mediator of C-reactive protein (CRP). These results suggested that CSP1 may possess high potential in treating hypertension.
authors.affiliation: Department of Ultrasonography, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Street, Wuhan, China.
authors.forename: Feixiang
authors.initials: F
authors.lastname: Xiang
authors.affiliation: Department of Cardiothoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Street, Wuhan, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Cardiothoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Street, Wuhan, China.. Electronic address: huminchn@hotmail.com.
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.affiliation: Department of Ultrasonography, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Street, Wuhan, China.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Qi
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015415:Biomarkers; D001794:Blood Pressure / Q000187:drug effects; D032661:Cordyceps / Q000737:chemistry*; D062610:Fungal Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011918:Rats, Inbred SHR; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D062610:Fungal Polysaccharides
keywords: Cordyceps sinensis; Hypertension; Polysaccharides