title: Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study.
abstract: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented.
  
  
  
  24 CF-Units for adult (n=12) and pediatric (n=12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed.
  
  
  
  341 patients [mean (SD) age 21 (11) years, 180≥18years, mean (SD) FEV1=68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p<0.001 and p=0.003, respectively).
  
  
  
  The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.
authors.affiliation: Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigaciones Sanitarias, Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: de Dios Caballero
authors.affiliation: Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigaciones Sanitarias, Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Del Campo
authors.affiliation: CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Unidad de Bioestadística Clínica, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Royuela
authors.affiliation: Unidad de Trasplante Pulmonar y Fibrosis Quística, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
authors.forename: Amparo
authors.initials: A
authors.lastname: Solé
authors.affiliation: Servicio de Neumología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Máiz
authors.affiliation: Servicio de Neumología, Hospital Regional Universitario de Málaga, Málaga, Spain.
authors.forename: Casilda
authors.initials: C
authors.lastname: Olveira
authors.affiliation: Unidad de Fibrosis Quística. Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Sevilla, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Quintana-Gallego
authors.affiliation: CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Department of Pulmonology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: de Gracia
authors.affiliation: Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigaciones Sanitarias, Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Cobo
authors.affiliation: Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigaciones Sanitarias, Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain.
authors.forename: Elia Gómez G
authors.initials: EG
authors.lastname: de la Pedrosa
authors.affiliation: Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain; Servicio de Microbiología y Unidad de Investigación, Hospital Universitario Son Espases and Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Oliver
authors.affiliation: Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigaciones Sanitarias, Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain. Electronic address: rafael.canton@salud.madrid.org.
authors.forename: Rafael
authors.initials: R
authors.lastname: Cantón
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D060085:Coinfection / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008168:Lung / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D015995:Prevalence; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012129:Respiratory Function Tests / Q000379:methods; D013030:Spain / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Cystic fibrosis; P. aeruginosa; Pulmonary infection–colonization; Respiratory pathogens