title: [Successful combination treatment for psoriasis with phototherapy and low-dose cytokines: A spontaneous, retrospective observational clinical study].
abstract: BACKGROUND
  Psoriasis is a chronic, inflammatory autoimmune skin disease that affects 1-3% of the world's population. Most patients with psoriasis have plaque psoriasis or psoriasis vulgaris, characterized by thickened erythematous scaly plaques and presenting in a variety of forms with distinct characteristics. Psoriasis is associated with a decreased quality of life as well as with severe comorbidities.
  
  
  OBJECTIVE
  The aim of this spontaneous, retrospective observational clinical study was to evaluate the pharmacological activity of advanced treatment based on the use of UVA-1 laser therapy with or without the co-administration of low dose cytokines [interleukin (IL)-4, IL-10] and anti-IL-1 antibodies in patients affected by psoriasis vulgaris.
  
  
  RESULTS
  In this study the efficacy of UVA-1 phototherapy and, in parallel, the decisive (statistically relevant) boosting activity of low-dose cytokines in ameliorating the Psoriasis Area Severity Index (PASI) score were assessed. These results show the effectiveness of combined use of phototherapy and low-dose cytokines therapy, highlighting the fundamental role of anti-inflammatory cytokines (IL-4, IL-10, anti-IL-1 antibodies) in the treatment of psoriasis vulgaris.
  
  
  CONCLUSIONS
  Further studies are necessary to confirm these preliminary data.
authors.affiliation: Università degli Studi Guglielmo Marconi, Via Plinio, 44, 00193, Rome, Italien. professor@torellolotti.it.|Institute of Dermatology LifeCronos, Florence, Italien. professor@torellolotti.it.|World Health Academy Foundation, Zürich (CH), Schweiz. professor@torellolotti.it.
authors.forename: T
authors.initials: T
authors.lastname: Lotti
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy / Q000379:methods; D016207:Cytokines / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D007167:Immunotherapy / Q000379:methods; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy / Q000379:methods*; D010865:Pilot Projects; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D011838:Radiation-Sensitizing Agents
keywords: Anti-IL-1 antibody; Interleukin-10; Interleukin-4; Plaque psoriasis; Psoriasis vulgaris