title: Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.
abstract: The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.
authors.affiliation: Department of Natural Resources Engineering and Management, University of Kurdistan, Hewler 44003, Iraq.
authors.forename: Saima
authors.initials: S
authors.lastname: Jadoon
authors.affiliation: University College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan.
authors.forename: Sabiha
authors.initials: S
authors.lastname: Karim
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Muhammad Hassham Hassan
authors.initials: MH
authors.lastname: Bin Asad
authors.affiliation: Department of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
authors.forename: Muhammad Rouf
authors.initials: MR
authors.lastname: Akram
authors.affiliation: Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Abida Kalsoom
authors.initials: AK
authors.lastname: Khan
authors.affiliation: Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore 54000, Pakistan.
authors.forename: Arif
authors.initials: A
authors.lastname: Malik
authors.affiliation: Key Laboratory of Biorheological Science and Technology, Chongqing University, Chongqing 400030, China.
authors.forename: Chunye
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D015595:Skin Aging / Q000187:drug effects*; D063465:Skin Cream / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D010936:Plant Extracts