title: CD25 expression on residual leukemic blasts at the time of allogeneic hematopoietic stem cell transplant predicts relapse in patients with acute myeloid leukemia without complete remission.
abstract: Recent studies have shown that CD25 expression at the time of diagnosis of acute myeloid leukemia (AML) may be associated with an unfavorable outcome. We focus on patients with AML without complete remission (CR) and examine the clinical correlation between surface CD25 expression at the time of transplant and subsequent transplant outcomes. We observed a significant difference in overall survival (OS), disease-free survival (DFS) and cumulative incidence of relapse (CIR) between CD25 positive (+) (n = 22) and negative (-) groups (n = 44) (2-year OS; CD25 (+) group: 5% vs. CD25 (-) group: 40%, p < 0.0001, 2-year DFS; 5% vs. 29%, p < 0.0001, 2-year CIR; 77% vs. 52%, p = 0.03). Multivariate analysis showed that CD25 expression was an independent adverse factor for OS (p = 0.002) and relapse (p = 0.001). Patients with AML with residual CD25 positive blasts at the time of transplant may require additional therapy before or after transplant to improve survival.
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Ikegawa
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Noriko
authors.initials: N
authors.lastname: Doki
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Shuhei
authors.initials: S
authors.lastname: Kurosawa
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sakaguchi
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Kaito
authors.initials: K
authors.lastname: Harada
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Keita
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Hino
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Naoki
authors.initials: N
authors.lastname: Shingai
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Senoo
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Hattori
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Aiko
authors.initials: A
authors.lastname: Igarashi
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Yuho
authors.initials: Y
authors.lastname: Najima
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kakihana
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakamaki
authors.affiliation: b Division of Transfusion and Cell Therapy , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Haraguchi
authors.affiliation: b Division of Transfusion and Cell Therapy , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Okuyama
authors.affiliation: a Division of Hematology , Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , Tokyo , Japan ;
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Ohashi
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002423:Cause of Death; D005260:Female; D005434:Flow Cytometry; D015870:Gene Expression; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016130:Immunophenotyping; D053645:Interleukin-2 Receptor alpha Subunit / Q000235:genetics / Q000378:metabolism*; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000175:diagnosis* / Q000378:metabolism*; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D012307:Risk Factors; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
chemical_list: D014408:Biomarkers, Tumor; D053645:Interleukin-2 Receptor alpha Subunit
keywords: Acute myeloid leukemia; CD25; allogeneic hematopoietic stem cell transplant; non-complete remission