title: Decreased baseline variability on fetal heart rate pattern in a fetus with heterotaxy syndrome.
abstract: In a fetus with suspected heterotaxy syndrome, a decreased/absent baseline variability of fetal heart rate pattern developed at gestational week 36(+5) and continued for 5 days until birth at gestational week 37(+2), while repeat biophysical profile scorings with ultrasound were consistently unremarkable. This neonate weighing 2404 g with Apgar scores of 7 (1-min) and 8 (5-min) and umbilical arterial cord blood pH of 7.28 with base deficit of 3.9 mmol/L, showed a heart rate of 120 b.p.m. for 3 h after birth, but subsequently developed sinus bradycardia (84 b.p.m.) unresponsive to crying. Isoproterenol initiated 9 h after birth was effective in the increase of heart rate to 120 b.p.m. in this neonate. Brain magnetic resonance imaging at 16 days of age was unremarkable. The decreased/absent baseline variability of fetal heart rate pattern was speculated to have been caused by sinus node dysfunction, and not by reduced fetal oxygenation in this case.
authors.affiliation: Center for Perinatal Medicine, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Yamada
authors.affiliation: Center for Perinatal Medicine, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Kohta
authors.initials: K
authors.lastname: Takei
authors.affiliation: Center for Perinatal Medicine, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kaneshi
authors.affiliation: Center for Perinatal Medicine, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Morikawa
authors.affiliation: Center for Perinatal Medicine, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Cho
authors.affiliation: Center for Perinatal Medicine, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Hisanori
authors.initials: H
authors.lastname: Minakami
mesh_terms: D000328:Adult; D005260:Female; D006340:Heart Rate, Fetal / Q000502:physiology*; D059446:Heterotaxy Syndrome / Q000503:physiopathology*; D006801:Humans; D011247:Pregnancy
keywords: cardiotocogram; congenital cardiac malformation; fetal arrhythmia; fetal heart rate pattern; isomerism