title: The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia.
abstract: Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P=0.0025), shorter leukemia-free survival (P=0.026) and higher cumulative incidence of relapse (P=0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P=0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML.
authors.affiliation: Hematology Department, IDIBAPS, Hospital Clinic, Barcelona, Spain.|Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Díaz-Beyá
authors.affiliation: Josep Carreras Leukaemia Research Institute, Barcelona, Spain.|Hematology Department and Biological Hematology Laboratory, Hospital de Sant Pau, Barcelona, IIB-Sant Pau Research Institute, Universitat Autonoma of Barcelona, Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Brunet
authors.affiliation: Josep Carreras Leukaemia Research Institute, Barcelona, Spain.|Hematology Department and Biological Hematology Laboratory, Hospital de Sant Pau, Barcelona, IIB-Sant Pau Research Institute, Universitat Autonoma of Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Nomdedéu
authors.affiliation: Molecular Oncology and Embryology Laboratory, Human Anatomy Unit, School of Medicine, University of Barcelona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Cordeiro
authors.affiliation: Hematology Department, Hospital Clínico, Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Tormo
authors.affiliation: Hematology Department, Hospital Joan XXIII, Tarragona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Escoda
authors.affiliation: Josep Carreras Leukaemia Research Institute, Barcelona, Spain.|Hematology Department, Institut Català d'Oncologia (ICO)-Hospital Germans Trias i Pujol, Badalona, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Ribera
authors.affiliation: ICO, Hematology Department, Hospital Duran i Reynals, l'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Arnan
authors.affiliation: Hematology Department, Hospital Morales Meseguer, Murcia, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Heras
authors.affiliation: Hematology Department, ICO Josep Trueta, Girona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Gallardo
authors.affiliation: Hematology Department, Hospital de Son Llàtzer, Palma de Mallorca Hematology, Palma de Mallorca, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Bargay
authors.affiliation: Hematology Department, Hospital Virgen de la Victoria, Malaga, Spain.
authors.forename: M P
authors.initials: MP
authors.lastname: Queipo de Llano
authors.affiliation: Hematology Department, Hospital Vall d'Hebron, Barcelona, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Salamero
authors.affiliation: Hematology Department, Hospital Mutua de Terrassa, Barcelona, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Martí
authors.affiliation: Hematology Department, Hospital de Son Llàtzer, Palma of Mallorca, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Sampol
authors.affiliation: Hematology Department, Hospital de Mar, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Pedro
authors.affiliation: Hematology Department and Biological Hematology Laboratory, Hospital de Sant Pau, Barcelona, IIB-Sant Pau Research Institute, Universitat Autonoma of Barcelona, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Hoyos
authors.affiliation: Hematology Department, IDIBAPS, Hospital Clinic, Barcelona, Spain.|Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pratcorona
authors.affiliation: Molecular Oncology and Embryology Laboratory, Human Anatomy Unit, School of Medicine, University of Barcelona, Barcelona, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Castellano
authors.affiliation: Hematology Department, IDIBAPS, Hospital Clinic, Barcelona, Spain.|Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Nomdedeu
authors.affiliation: Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
authors.forename: R M
authors.initials: RM
authors.lastname: Risueño
authors.affiliation: Josep Carreras Leukaemia Research Institute, Barcelona, Spain.|Hematology Department and Biological Hematology Laboratory, Hospital de Sant Pau, Barcelona, IIB-Sant Pau Research Institute, Universitat Autonoma of Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Sierra
authors.affiliation: Molecular Oncology and Embryology Laboratory, Human Anatomy Unit, School of Medicine, University of Barcelona, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Monzó
authors.affiliation: Molecular Oncology and Embryology Laboratory, Human Anatomy Unit, School of Medicine, University of Barcelona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Navarro
authors.affiliation: Hematology Department, IDIBAPS, Hospital Clinic, Barcelona, Spain.|Josep Carreras Leukaemia Research Institute, Barcelona, Spain.|University of Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Esteve
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D020732:Cytogenetic Analysis; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D059467:Transcriptome; D055815:Young Adult
chemical_list: C442828:BAALC protein, human; D014408:Biomarkers, Tumor; C000593307:MIRN3151 microRNA, human; D035683:MicroRNAs; D009363:Neoplasm Proteins