title: The Impact of CDH13 Polymorphism and Statin Administration on TG/HDL Ratio in Cardiovascular Patients.
abstract: OBJECTIVE
  Adiponectin is expressed in adipose tissue, and is affected by smoking, obesity, and genetic factors, such as CDH13 polymorphism, contributing to the development of coronary vascular diseases (CVDs).
  
  
  METHODS
  We investigated the effect of genetic variations of CDH13 (rs3865188) on blood chemistry and adiponectin levels in 345 CVD patients undergoing statin-free or statin treatment.
  
  
  RESULTS
  Genetic variation in CDH13 was significantly correlated with several clinical factors, including adiponectin, diastolic blood pressure, triglyceride (TG), and insulin levels. Subjects with the T allele (mutant form) had significantly lower adiponectin levels than those with the A allele. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), TG/high-density lipoprotein cholesterol (HDLc) ratio, and HDL3b subtype were markedly decreased in statin treated subjects regardless of having the A or T allele. TG and TG/HDL in the statin-free group with TT genotype of the rs3865188 was higher than in the others but they were not different in the statin-treated subjects. We observed a significant difference in adiponectin levels between patients with the A and T alleles in the statin-free group; meanwhile, no difference in adiponectin levels was noted in the statin group. Plasma levels of other cytokines, leptin, visfatin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), were not different among the CDH13 genotypes according to statin administration. Body mass index (BMI), TG, insulin, HDL3b, and TG/HDL ratio showed negative correlations with adiponectin levels.
  
  
  CONCLUSIONS
  Plasma adiponectin levels and TG/HDL ratio were significantly different according to variants of CDH13 and statin administration in Korean patients with CVD.
authors.affiliation: Department of Food and Nutrition, and Research Institute of Obesity Sciences, Sungshin Women's University, Seoul, Korea.
authors.forename: Jung Ran
authors.initials: JR
authors.lastname: Choi
authors.affiliation: Cardiovascular Genome Center, Cardiology Division, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. jangys1212@yuhs.ac.
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.affiliation: Research Institute of Molecular Genetics, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sungjoo
authors.initials: S
authors.lastname: Kim Yoon
authors.affiliation: Research Institute of Molecular Genetics, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jong Keun
authors.initials: JK
authors.lastname: Park
authors.affiliation: School of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sungbin Richard
authors.initials: SR
authors.lastname: Sorn
authors.affiliation: Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul, Korea.
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Park
authors.affiliation: Department of Food and Nutrition, and Research Institute of Obesity Sciences, Sungshin Women's University, Seoul, Korea. mlee@sungshin.ac.kr.
authors.forename: Myoungsook
authors.initials: M
authors.lastname: Lee
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000328:Adult; D000368:Aged; D000483:Alleles; D001794:Blood Pressure / Q000235:genetics; D015992:Body Mass Index; D015820:Cadherins / Q000097:blood / Q000235:genetics*; D002784:Cholesterol; D008078:Cholesterol, LDL; D005260:Female; D005838:Genotype; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007328:Insulin; D015850:Interleukin-6; D020738:Leptin / Q000235:genetics; D008075:Lipoproteins, HDL / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D014652:Vascular Diseases / Q000188:drug therapy*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015820:Cadherins; D008078:Cholesterol, LDL; C034396:HDL-triglyceride; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C508600:IL6 protein, human; D007328:Insulin; D015850:Interleukin-6; D020738:Leptin; D008075:Lipoproteins, HDL; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol
keywords: Adiponectin; CDH13; HDL3b; TG/HDL; statin