title: Performance of Momguard, a new non-invasive prenatal testing protocol developed in Korea.
abstract: OBJECTIVE
  To evaluate the performance of Momguard, non-invasive prenatal test (NIPT) for detecting trisomy (T) 21, T18, T13, and sex-chromosome abnormalities recently developed in Korea.
  
  
  METHODS
  This preliminary study formed part of a large prospective cohort study conducted at Asan Medical Center, Seoul, Korea. Only pregnant women who underwent both NIPT and confirmatory karyotyping were included in this study. NIPT results were compared with those of karyotype analyses.
  
  
  RESULTS
  Among 93 eligible cases, NIPT results could not be obtained in one case due to a low fetal cell-free DNA fraction. Based on NIPT, eight cases of fetal aneuploidies, including T21 (n=5), T18 (n=2), and T13 (n=1), were identified. For T21 and T18, the sensitivity and specificity of NIPT were both 100%, with a false-positive and false-negative rate of 0% and a positive-predictive value of 100%. One patient classified as having intermediate risk for T13 by NIPT was confirmed to have T13 by karyotyping, and there were no false-negative cases. No cases of sex-chromosome anomalies were detected by NIPT or karyotyping during the study period.
  
  
  CONCLUSIONS
  Momguard is a reliable screening tool for detecting T21 and T18. For T13 and sex-chromosome anomalies, further prospective studies are necessary to confirm its utility.
authors.affiliation: Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Lee
authors.affiliation: LabGenomics Clinical Research Institute, LabGenomics, Seongnam, Korea.
authors.forename: Dae-Yeon
authors.initials: DY
authors.lastname: Cho
authors.affiliation: Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Hye-Sung
authors.initials: HS
authors.lastname: Won
authors.affiliation: Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Ah Reum
authors.initials: AR
authors.lastname: Hwang
authors.affiliation: Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Bada
authors.initials: B
authors.lastname: Jeong
authors.affiliation: LabGenomics Clinical Research Institute, LabGenomics, Seongnam, Korea.
authors.forename: Jihun
authors.initials: J
authors.lastname: Kim
authors.affiliation: LabGenomics Clinical Research Institute, LabGenomics, Seongnam, Korea.
authors.forename: Mijin
authors.initials: M
authors.lastname: Oh
keywords: Aneuploidy; Down syndrome; Patau syndrome; Prenatal diagnosis; Trisomy 18