title: Cardiac factors affecting the success of vardenafil in erectile dysfunction.
abstract: OBJECTIVE
  To evaluate the predictability of vardenafil success in patients with erectile dysfunction (ED) by using cardiological tests.
  
  
  METHODS
  Patients diagnosed with ED who did not benefit from lifestyle changes (n = 68) were evaluated with an abridged 5-item version of the International Index of Erectile Function (IIEF-5). The pretreatment and posttreatment IIEF-5 scores were compared with pretreatment data obtained from cardiological examinations.
  
  
  RESULTS
  When pretreatment scores were compared with test parameters, mitral flow E/A ratio and tissue Doppler imaging (TDI) E'/ A', exercise test duration, exercise capacity in MET, and percentage of maximum heart rate were found to be statistically significant. Furthermore, there was a significant negative correlation between mitral flow E/A ratio, TDI E'/A', exercise test duration, exercise capacity in MET, and the difference in post- and pretreatment IIEF-5 scores.
  
  
  CONCLUSIONS
  As a diastolic function indicator, TDI E'/A' positively correlates with pretreatment IIEF-5 scores and negatively correlates with the beneficial effect of vardenafil treatment. As a result, the cardiological status of the patient correlates with individual IIEF-5 scores, and it seems to be useful in predicting vardenafil success.
authors.forename: Kürşad
authors.initials: K
authors.lastname: Zengin
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ede
authors.forename: Serhat
authors.initials: S
authors.lastname: Tanik
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Albayrak
authors.forename: Savaş
authors.initials: S
authors.lastname: Sarikaya
authors.forename: Aliriza
authors.initials: A
authors.lastname: Erbay
authors.forename: Muhammet Abdurrahim
authors.initials: MA
authors.lastname: Imamoğlu
authors.forename: Mesut
authors.initials: M
authors.lastname: Gürdal
mesh_terms: D001682:Biological Availability; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology; D016903:Drug Monitoring / Q000379:methods; D015150:Echocardiography, Doppler / Q000379:methods; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000187:drug effects*; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics; D010879:Piperazines / Q000008:administration & dosage / Q000493:pharmacokinetics; D011237:Predictive Value of Tests; D013223:Statistics as Topic; D013450:Sulfones / Q000008:administration & dosage / Q000493:pharmacokinetics; D016896:Treatment Outcome; D014227:Triazines / Q000008:administration & dosage / Q000493:pharmacokinetics; D000069058:Vardenafil Dihydrochloride
chemical_list: D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D013450:Sulfones; D014227:Triazines; D000069058:Vardenafil Dihydrochloride