title: Development of pH sensitive microparticles of Karaya gum: By response surface methodology.
abstract: The objective of the proposed work was to prepare pH sensitive microparticles (MP) of Karaya gum using distilled water as a solvent by spray drying technique. Different formulations were designed, prepared and evaluated by employing response surface methodology and optimal design of experiment technique using Design Expert(®) ver 8.0.1 software. SEM photographs showed that MP were roughly spherical in shape and free from cracks. The particle size and encapsulation efficiency for optimized MP was found to be between 3.89 and 6.5 μm and 81-94% respectively with good flow properties. At the end of the 12th hour the in vitro drug release was found to be 96.9% for the optimized formulation in pH 5.6 phosphate buffer. Low prediction errors were observed for Cmax and AUC0-∞ which demonstrated that the Frusemide IVIVC model was valid. Hence it can be concluded that pH sensitive MP of Karaya gum were effectively prepared by spray drying technique using aqueous solvents and can be used for treating various diseases like chronic hypertension, Ulcerative Colitis and Diverticulitis.
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, 570015, Karnataka, India.
authors.forename: Abhay
authors.initials: A
authors.lastname: Raizaday
authors.affiliation: Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, RAK Medical and Health Science University, UAE. Electronic address: haisunny2@yahoo.co.in.
authors.forename: Hemant K S
authors.initials: HK
authors.lastname: Yadav
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, 570015, Karnataka, India.
authors.forename: S Hemanth
authors.initials: SH
authors.lastname: Kumar
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, 570015, Karnataka, India.
authors.forename: Susmitha
authors.initials: S
authors.lastname: Kasina
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, 570015, Karnataka, India.
authors.forename: M
authors.initials: M
authors.lastname: Navya
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, 570015, Karnataka, India.
authors.forename: C
authors.initials: C
authors.lastname: Tashi
keywords: 1; 2-propylene glycol (PubChemCID: 1030); Acetonitrile (PubChemCID: 6342); Aqueous solvent; Dichloromethane (PubChem CID: 14709377); Frusemide (PubChemCID: 3440); Glutaraldehyde (PubChemCID: 110991); Hydrochloric acid (PubChem: CID 313); IVIVC; In vivo studies; Methanol (PubChemCID: 887); Microparticles; Optimization; Sodium chloride (PubChem: CID 5234); Validation