title: Sesquiterpenes from the Vietnamese Marine Sponge Dysidea fragilis.
abstract: Two new sesquiterpenes, named dysinidins A-B (3, 4) along with two known sesquiterpenes, furodysinin lactone (1) and O-methyl urodysinin lactone (2), were isolated from the Vietnamese marine sponge Dysidea fragilis. Their structures were determined by ID- and 2D-NMR spectroscopies and HR ESI MS, as well as by comparison with reported literature data. None of compounds showed inhibitory growth of human lung cancer cell lines, A-549 and H-1975 (IC50 > 30 μM).
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Cue
authors.forename: Hoang Le Tuan
authors.initials: Hle T
authors.lastname: Anh
authors.forename: Dan Thi Thuy
authors.initials: DT
authors.lastname: Hang
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Nguyen Hai
authors.initials: NH
authors.lastname: Dang
authors.forename: Nguyen Hoai
authors.initials: NH
authors.lastname: Nama
authors.forename: Pham Hai
authors.initials: PH
authors.lastname: Yen
authors.forename: Do Cong
authors.initials: do C
authors.lastname: Thung
authors.forename: Vu Kim
authors.initials: VK
authors.lastname: Thuc
authors.forename: Chan Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiema
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047088:Dysidea / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014744:Vietnam
chemical_list: D012717:Sesquiterpenes