title: The GSTome Reflects the Chemical Environment of White-Rot Fungi.
abstract: White-rot fungi possess the unique ability to degrade and mineralize all the different components of wood. In other respects, wood durability, among other factors, is due to the presence of extractives that are potential antimicrobial molecules. To cope with these molecules, wood decay fungi have developed a complex detoxification network including glutathione transferases (GST). The interactions between GSTs from two white-rot fungi, Trametes versicolor and Phanerochaete chrysosporium, and an environmental library of wood extracts have been studied. The results demonstrate that the specificity of these interactions is closely related to the chemical composition of the extracts in accordance with the tree species and their localization inside the wood (sapwood vs heartwood vs knotwood). These data suggest that the fungal GSTome could reflect the chemical environment encountered by these fungi during wood degradation and could be a way to study their adaptation to their way of life.
authors.affiliation: Université de Lorraine, Interactions Arbres-Microorganismes, UMR1136, F-54500, Vandoeuvre-lès-Nancy, France; INRA, Interactions Arbres-Microorganismes, UMR1136, F-54280, Champenoux, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Deroy
authors.affiliation: Université de Lorraine, Interactions Arbres-Microorganismes, UMR1136, F-54500, Vandoeuvre-lès-Nancy, France; INRA, Interactions Arbres-Microorganismes, UMR1136, F-54280, Champenoux, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Saiag
authors.affiliation: Laboratoire d'Etudes et de Recherches sur le Matériau Bois, EA4370 Université de Lorraine USC INRA, Faculté des Sciences et Technologies, 54506, Vandoeuvre-les-Nancy, France; AgroParisTech, UMR 1092 LERFOB, F-54000, Nancy, France; INRA, UMR 1092 LERFOB, F-54280, Champenoux, France.
authors.forename: Zineb
authors.initials: Z
authors.lastname: Kebbi-Benkeder
authors.affiliation: Laboratoire d'Etudes et de Recherches sur le Matériau Bois, EA4370 Université de Lorraine USC INRA, Faculté des Sciences et Technologies, 54506, Vandoeuvre-les-Nancy, France; AgroParisTech, UMR 1092 LERFOB, F-54000, Nancy, France; INRA, UMR 1092 LERFOB, F-54280, Champenoux, France.
authors.forename: Nassim
authors.initials: N
authors.lastname: Touahri
authors.affiliation: Université de Lorraine, Interactions Arbres-Microorganismes, UMR1136, F-54500, Vandoeuvre-lès-Nancy, France; INRA, Interactions Arbres-Microorganismes, UMR1136, F-54280, Champenoux, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Hecker
authors.affiliation: Université de Lorraine, Interactions Arbres-Microorganismes, UMR1136, F-54500, Vandoeuvre-lès-Nancy, France; INRA, Interactions Arbres-Microorganismes, UMR1136, F-54280, Champenoux, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Morel-Rouhier
authors.affiliation: AgroParisTech, UMR 1092 LERFOB, F-54000, Nancy, France; INRA, UMR 1092 LERFOB, F-54280, Champenoux, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Colin
authors.affiliation: Laboratoire d'Etudes et de Recherches sur le Matériau Bois, EA4370 Université de Lorraine USC INRA, Faculté des Sciences et Technologies, 54506, Vandoeuvre-les-Nancy, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Dumarcay
authors.affiliation: Laboratoire d'Etudes et de Recherches sur le Matériau Bois, EA4370 Université de Lorraine USC INRA, Faculté des Sciences et Technologies, 54506, Vandoeuvre-les-Nancy, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gérardin
authors.affiliation: Université de Lorraine, Interactions Arbres-Microorganismes, UMR1136, F-54500, Vandoeuvre-lès-Nancy, France; INRA, Interactions Arbres-Microorganismes, UMR1136, F-54280, Champenoux, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Gelhaye
mesh_terms: D000096:Acetone / Q000737:chemistry; D023281:Genomics; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism*; D020075:Phanerochaete / Q000201:enzymology* / Q000235:genetics* / Q000502:physiology; D010936:Plant Extracts / Q000378:metabolism; D011485:Protein Binding; D013379:Substrate Specificity; D055454:Trametes / Q000201:enzymology* / Q000235:genetics* / Q000502:physiology; D014934:Wood / Q000737:chemistry / Q000382:microbiology
chemical_list: D010936:Plant Extracts; D000096:Acetone; D005982:Glutathione Transferase