title: Effect of DISC1 polymorphisms on the long-term course of neurocognitive deficits in non-affective psychosis.
abstract: Neurocognitive deficits are core symptoms of schizophrenia that determine a poorer outcome. High variability in the progression of neuropsychological deficits in schizophrenia has been described. It is still unknown whether genetic variations can affect the course of cognitive deficits. Variations in the Disrupted in Schizophrenia 1 (DISC1) gene have previously been associated with neurocognitive deficits. This study investigated the association between 3 DISC1 polymorphisms (rs6675281 (Leu607Phe), rs1000731, and rs821616 (Ser704Cys)) and long-term (3 years) cognitive performance. One-hundred-thirty-three Caucasian drug-naive patients experiencing a first episode of non-affective psychosis were genotyped. Cognitive function was assessed at baseline and after 3 years of initiating treatment. Other clinical and socio-demographic variables were recorded to eliminate potential confounding effects. Patients carrying the A allele of rs1000731 exhibited a significant improvement in Working Memory and Attention domains, and the homozygosity of the A allele of rs821616 showed a significant improvement in Motor Dexterity performance over 3 years of follow-up. In conclusion, DISC1 gene variations may affect the course of cognitive deficits found in patients suffering from the first episode of non-affective psychosis.
authors.affiliation: University Hospital Marqués de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain; IDIVAL, Instituto de Investigación Marqués de Valdecilla, Santander, Spain. Electronic address: javazquez@humv.es.
authors.forename: J
authors.initials: J
authors.lastname: Vázquez-Bourgon
authors.affiliation: University Hospital Marqués de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain; IDIVAL, Instituto de Investigación Marqués de Valdecilla, Santander, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Ayesa-Arriola
authors.affiliation: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain; Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Fatjó-Vilas
authors.affiliation: University Hospital Marqués de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain; IDIVAL, Instituto de Investigación Marqués de Valdecilla, Santander, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Roiz-Santiañez
authors.affiliation: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain; Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Fañanás
authors.affiliation: University Hospital Marqués de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain; IDIVAL, Instituto de Investigación Marqués de Valdecilla, Santander, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Crespo-Facorro
mesh_terms: D000328:Adult; D000483:Alleles; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011618:Psychotic Disorders / Q000235:genetics; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*
chemical_list: C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins
keywords: Cognitive impairment; DISC1; Genetics; Long-term course; Schizophrenia