title: MAGiC: VOC remains but kids with SCA appear.
abstract: In this issue of Blood, Brousseau et al report results from the Magnesium for Children in Crisis (MAGiC; #NCT01197417) trial. This multicenter, double-blind, placebo-controlled trial compared the effects of intravenous magnesium to saline in children with sickle cell anemia (SCA) admitted to the hospital for acute vaso-occlusive pain (VOC). Although magnesium was found to be ineffective, MAGiC illustrates an effective strategy for rapid and efficient patient accrual in pediatric SCA studies.
authors.affiliation: ST. JUDE CHILDREN RESEARCH HOSPITAL.
authors.forename: Jeremie Heath
authors.initials: JH
authors.lastname: Estepp
mesh_terms: D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage*; D008297:Male; D010146:Pain / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D008274:Magnesium