title: Mood instability: significance, definition and measurement.
abstract: Mood instability is common, and an important feature of several psychiatric disorders. We discuss the definition and measurement of mood instability, and review its prevalence, characteristics, neurobiological correlates and clinical implications. We suggest that mood instability has underappreciated transdiagnostic potential as an investigational and therapeutic target.
authors.affiliation: M. R. Broome, PhD, MRCPsych, Department of Psychiatry, University of Oxford, Oxford, Oxford Health NHS Foundation Trust, Oxford and Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry; K. E. A. Saunders, DPhil, MRCPsych, P. J. Harrison, DM, FRCPsych, Department of Psychiatry, University of Oxford, Oxford; S. Marwaha, PhD, MRCPsych, Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry and Early Intervention Service, Swanswell Point, Coventry, UK matthew.broome@psych.ox.ac.uk.
authors.forename: M R
authors.initials: MR
authors.lastname: Broome
authors.affiliation: M. R. Broome, PhD, MRCPsych, Department of Psychiatry, University of Oxford, Oxford, Oxford Health NHS Foundation Trust, Oxford and Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry; K. E. A. Saunders, DPhil, MRCPsych, P. J. Harrison, DM, FRCPsych, Department of Psychiatry, University of Oxford, Oxford; S. Marwaha, PhD, MRCPsych, Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry and Early Intervention Service, Swanswell Point, Coventry, UK.
authors.forename: K E A
authors.initials: KE
authors.lastname: Saunders
authors.affiliation: M. R. Broome, PhD, MRCPsych, Department of Psychiatry, University of Oxford, Oxford, Oxford Health NHS Foundation Trust, Oxford and Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry; K. E. A. Saunders, DPhil, MRCPsych, P. J. Harrison, DM, FRCPsych, Department of Psychiatry, University of Oxford, Oxford; S. Marwaha, PhD, MRCPsych, Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry and Early Intervention Service, Swanswell Point, Coventry, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Harrison
authors.affiliation: M. R. Broome, PhD, MRCPsych, Department of Psychiatry, University of Oxford, Oxford, Oxford Health NHS Foundation Trust, Oxford and Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry; K. E. A. Saunders, DPhil, MRCPsych, P. J. Harrison, DM, FRCPsych, Department of Psychiatry, University of Oxford, Oxford; S. Marwaha, PhD, MRCPsych, Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry and Early Intervention Service, Swanswell Point, Coventry, UK.
authors.forename: S
authors.initials: S
authors.lastname: Marwaha
mesh_terms: D003071:Cognition; D006801:Humans; D007508:Irritable Mood; D019964:Mood Disorders / Q000175:diagnosis* / Q000628:therapy*