title: Next-Generation Sequencing for the Identification of Targetable Molecular Alterations in Cancer.
authors.affiliation: Harold C. Simmons Cancer Center, Division of Hematology-Oncology, University of Texas Southwestern Medical Center, Dallas.
authors.forename: Martin F
authors.initials: MF
authors.lastname: Dietrich
authors.affiliation: Harold C. Simmons Cancer Center, Division of Hematology-Oncology, University of Texas Southwestern Medical Center, Dallas.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Collins
authors.affiliation: Harold C. Simmons Cancer Center, Division of Hematology-Oncology, University of Texas Southwestern Medical Center, Dallas.
authors.forename: David E
authors.initials: DE
authors.lastname: Gerber
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics*; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006162:Guanylate Cyclase / Q000235:genetics*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D058990:Molecular Targeted Therapy; D009154:Mutation; D018579:Patient Selection; D010641:Phenotype; D010880:Piperidines; D057285:Precision Medicine; D011237:Predictive Value of Tests; D011720:Pyrazoles / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D053468:CARD Signaling Adaptor Proteins; D010880:Piperidines; D011720:Pyrazoles; D011743:Pyrimidines; C551803:ibrutinib; C426242:CARD11 protein, human; D006162:Guanylate Cyclase; D000225:Adenine