title: Very Early Lactate Threshold in Healthy Young Men as Related to Oxygen Uptake Kinetics.
abstract: We assessed the correspondence between the V-slope ventilatory threshold (VT) and the lactate threshold (LT) by using a distinctive slow submaximal ramp protocol to ensure that sufficient data points exist around the threshold. Twenty healthy young men participated. A submaximal test based on a prior maximal test (25 watt/min, medium ramp) was performed with an individual slow-ramp protocol (6-17 watt/min, slow ramp), in which the time to reach the VT workload was estimated to be 10 minutes. The LT was determined visually by detecting a rise above the resting value, without or with log-log transformation (LT1, LT2). The point at which the blood lactate exceeded the minimal difference (LMD) of 2 resting values was also calculated. The VT appeared significantly earlier under the slow-ramp protocol compared to the medium-ramp protocol (from 19.3 ± 3.9 to 15.0 ± 4.0 mL/kg/min VO2, P < 0.001). The mean LT1 and LT2 values appeared even earlier than the VT (LT1, P = 0.004; LT2, P = 0.002) (LT1, 11.9; LT2, 13.4; LMD, 17.0; VT, 15.0 mL/kg/min VO2). As the mean % of peak VO2, each occurred at 29.9%, 33.7%, 42.5%, and 37.8%. The VT correlated significantly with LT1, LT2, and LMD (r = 0.61, 0.64, 0.80; P = 0.004, 0.002, <0.001). Mean blood lactate showed a similar trend (1.30, 1.43, 1.81, 1.68 mmol/L, respectively). Furthermore, the ΔVO2/Δ work rate slope increased (from 10.8 ± 0.9 to 11.5 ± 0.9; P = 0.01) with the slow ramp, and the lower LT was associated with the greater increase in slope (LT1, r = -0.47, P = 0.03; LT2, r = -0.59, P =  .005), that is, the lower LT was an indication that on the faster medium ramp the slope would decrease. The LMD and VT did not show this relation. Under slow-ramp exercise testing in healthy young men, the VT appeared earlier than under medium-ramp exercise testing. In addition, the LT appeared even earlier (at approximately 30% of peak VO2) than the VT, although they correlated. This very early onset of LT was, however, associated with evidence of reduced oxygen uptake kinetics.
authors.affiliation: From the Cardiac Rehabilitation Center (KK, HN, KI, TK, MM, MA); Department of Cardiovascular Medicine, Sapporo Ryokuai Hospital, Sapporo (HN, MA); and Department of Clinical Research, National Hospital Organization Hakodate Hospital, Hakodate, Japan (KY).
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kominami
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Nishijima
authors.forename: Keiko
authors.initials: K
authors.lastname: Imahashi
authors.forename: Toko
authors.initials: T
authors.lastname: Katsuragawa
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Murakami
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yonezawa
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Akino
mesh_terms: D001944:Breath Tests; D005080:Exercise Test / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D019344:Lactic Acid / Q000097:blood* / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D055815:Young Adult
chemical_list: D019344:Lactic Acid; D010100:Oxygen