title: Pseudomonas Exotoxin A: optimized by evolution for effective killing.
abstract: Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive evolution, how bacterial molecules have been structurally and functionally optimized under evolutionary pressure to effectively impair and kill their host cells.
authors.affiliation: Department of Urology, Medical Center, University of Freiburg Freiburg, Germany.
authors.forename: Marta
authors.initials: M
authors.lastname: Michalska
authors.affiliation: Department of Urology, Medical Center, University of Freiburg Freiburg, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Wolf
keywords: ADP ribosylation; Pseudomonas Exotoxin A; Pseudomonas aeruginosa; cytotoxic pathways; pathoadaptation; virulence factor