title: The safety of liposome bupivacaine 2 years post-launch: a look back and a look forward.
abstract: The need for better post-surgical pain management continues to be unmet, despite clinicians' awareness and concern for many years. Opioids remain the standard of care because of their analgesic efficacy; however, opioid use is often associated with adverse effects and poor patient outcomes. Multimodal analgesic regimens have recently been endorsed as a way to provide adequate post-surgical pain control while reducing opioid consumption. Liposome bupivacaine is a liposomal formulation of bupivacaine indicated for a single administration into the surgical site. Based on the available clinical trial data compiled to date, as well as the author's review of publicly available post-marketing safety information, liposome bupivacaine may be a viable addition to currently available therapeutic options for post-surgical analgesia while reducing potential risks associated with use of opioid analgesics, and may represent a useful addition to the multimodal analgesic modalities currently used for post-operative pain management. The potential for its use in other areas is also being investigated. The purpose of this review is to examine the currently available post-marketing safety information on liposome bupivacaine.
authors.affiliation: a Thomas Jefferson University, Acute Pain Management, Department of Anesthesiology , US 111 S. 11th Street, Suite G8490, Philadelphia, PA 19107, USA +1 21 59 55 61 61 ; +1 21 59 23 55 07 ; eugene.viscusi@jefferson.edu.
authors.forename: Eugene R
authors.initials: ER
authors.lastname: Viscusi
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects*; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008081:Liposomes; D010149:Postoperative Pain / Q000188:drug therapy*; D011358:Product Surveillance, Postmarketing
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D008081:Liposomes; D002045:Bupivacaine
keywords: analgesia; liposome bupivacaine; post-surgical pain