title: Complexation of pectin with macro- and microelements. Antianemic activity of Na, Fe and Na, Ca, Fe complexes.
abstract: New water-soluble pectin complexes with Ca(2+), Mg(2+), Co(2+), Cu(2+), Fe(2+), Mn(2+), Zn(2+) on the basis of pectin biopolymer have been synthesized and successfully tested on white rats. For a starting, we have obtained a sodium pectate to enhance solubility of target complexes as a whole. Shortly afterwards, running the reaction of ligand exchange of Nа(+) ions with corresponding s-, d- metal cations we were able to synthesize new pectin complexes. The ranges of s-, d-metals salts concentrations were detected experimentally, in which the selective formation of water-soluble complexes occurred. Antianemic effect of new pectin complexes with Na, Fe and Na, Ca, Fe was investigated on white rats with posthemorrhagic anemia. Under the effect of complexes, the improvement of animals and prevention of erythropoiesis disorders were observed. Antianemic effect of the complexes manifested itself in the doses equivalent to 25% or 50% of the iron daily rate, recommended in the treatment of iron-deficiency anemia with the drugs based on iron sulphate.
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia. Electronic address: minzanova@iopc.ru.
authors.forename: S T
authors.initials: ST
authors.lastname: Minzanova
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
authors.forename: V F
authors.initials: VF
authors.lastname: Mironov
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Vyshtakalyuk
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Tsepaeva
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
authors.forename: L G
authors.initials: LG
authors.lastname: Mironova
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Mindubaev
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
authors.forename: I R
authors.initials: IR
authors.lastname: Nizameev
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Kholin
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Milyukov
mesh_terms: D000740:Anemia / Q000150:complications / Q000188:drug therapy*; D000818:Animals; D002118:Calcium / Q000737:chemistry; D006470:Hemorrhage / Q000150:complications; D007501:Iron / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010368:Pectins / Q000737:chemistry*; D051381:Rats; D012964:Sodium / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D010368:Pectins; D012964:Sodium; D007501:Iron; D002118:Calcium
keywords: Anemia; Antianemic effect; Complexation; Macro- and microelements; Pectin complexes; s-, d-Metals