title: RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions.
abstract: Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in the biogenesis, turnover, translation and localization of mRNAs. This review will highlight recent advances in the understanding of the role of RBPs in the regulation of the maturation and the function of miRNAs. The interplay between miRNAs and RBPs is discussed specifically in the context of neuronal development and function.
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. a.loffreda@campus.unimib.it.
authors.forename: Alessia
authors.initials: A
authors.lastname: Loffreda
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. a.rigamonti8@campus.unimib.it.
authors.forename: Aurora
authors.initials: A
authors.lastname: Rigamonti
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. silvia.barabino@unimib.it.
authors.forename: Silvia M L
authors.initials: SM
authors.lastname: Barabino
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. silvia.lenzken@unimib.it.
authors.forename: Silvia C
authors.initials: SC
authors.lastname: Lenzken
mesh_terms: D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D016601:RNA-Binding Proteins
keywords: RBPs; RNA binding proteins; miRNA; miRNA-RBP competition; miRNA-RBP cooperation; neuronal-gene-expression-regulation