title: Effectiveness and Safety of Pulsed Radiofrequency Treatment Guided by Computed Tomography for Refractory Neuralgia of Infraorbital Nerve: A Pilot Study.
abstract: BACKGROUND
  There is no truly optimal treatment to cure refractory neuralgia of the infraorbital nerve. Recently, nondestructive pulsed radiofrequency (PRF) has become one of the most attractive interventional techniques for painful disorders. However, use of the technique for infraorbital neuralgia has been seldom reported.
  
  
  OBJECTIVE
  The purpose of this prospective study is to observe the effectiveness and safety of PRF treatment for neuralgia of the infraorbital nerve.
  
  
  METHODS
  Prospective case series clinical outcome study.
  
  
  METHODS
  University Medical Center, Beijing, China.
  
  
  METHODS
  From January 2011 to November 2012, 36 consecutive patients, following ineffective conservative therapy, underwent PRF treatment and completed 2-year follow-up. Numeric rating scales (NRS), effective rate, additional carbamazepine dosage, and side effects were recorded at postoperative day one, week one, week 2, month one, month 3, month 6, year one, and year 2. Patients were divided into effective group and ineffective group based on postoperative one -month total pain relief or more than 50% reduction in NRS and patients were satisfied with the effect, and possible factors affecting efficacy were compared between the 2 groups.
  
  
  RESULTS
  Effective rates were 69%, 69%, 64%, 50%, and 50% at postoperative month one, month 3, month 6, year one, and year 2, respectively. No serious side effects were observed, except that 9 patients felt short-term (one -month duration) mild numbness. Output voltage and tissue resistance in the effective group were significantly higher than the ineffective group (P < 0.01). Intraoperative output voltage was negatively correlated with postoperative one -month NRS (r = -0.332, P < 0.05).
  
  
  CONCLUSIONS
  The non-controlled and single-centered design of the study.
  
  
  CONCLUSIONS
  Results demonstrated PRF treatment under computed tomography (CT) guidance for infraorbital neuralgia is safe, effective, and is expected to become an alternative for patients experiencing ineffective conservative therapy. Increasing the output voltage of PRF could be the chosen method to improve the efficacy.
authors.affiliation: Department of Anesthesiology and Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Luo
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Meng
authors.affiliation: Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Ji
mesh_terms: D000368:Aged; D003389:Cranial Nerve Diseases / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008442:Maxillary Nerve / Q000503:physiopathology*; D008875:Middle Aged; D009437:Neuralgia / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D010865:Pilot Projects; D061208:Pulsed Radiofrequency Treatment / Q000009:adverse effects* / Q000379:methods*; D014057:Tomography, X-Ray Computed