title: CARD9 mutation linked to Corynespora cassiicola infection in a Chinese patient.
abstract: Corynespora cassiicola is a plant pathogen associated with leaf-spotting disease. The fungus has been found on diverse substrates: leaves, stems and roots of plants; nematode cysts and human skin. It rarely causes human infections. Here we report one case of subcutaneous phaeohyphomycosis caused by C. cassiicola with prominent tissue necrosis in a woman. All of her clinical features pointed towards a genetic linkage. Hence, whole-exome sequencing and Sanger sequencing were performed on this patient. One mutation of CARD9 was detected.
authors.affiliation: Shandong Clinical College of Skin Diseases, Anhui Medical University, Jinan, Shandong, China.|Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.|Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.
authors.forename: X X
authors.initials: XX
authors.lastname: Yan
authors.affiliation: Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.|Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.
authors.forename: C P
authors.initials: CP
authors.lastname: Yu
authors.affiliation: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.|Shandong Provincial Key Lab for Dermatovenereology, Jinan, Shandong, China.
authors.forename: X A
authors.initials: XA
authors.lastname: Fu
authors.affiliation: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.|Shandong Provincial Key Lab for Dermatovenereology, Jinan, Shandong, China.
authors.forename: F F
authors.initials: FF
authors.lastname: Bao
authors.affiliation: Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.|Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.
authors.forename: D H
authors.initials: DH
authors.lastname: Du
authors.affiliation: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.|Shandong Provincial Key Lab for Dermatovenereology, Jinan, Shandong, China.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.affiliation: Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.|Shandong Provincial Key Lab for Dermatovenereology, Jinan, Shandong, China.
authors.forename: N
authors.initials: N
authors.lastname: Wang
authors.affiliation: Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.|Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.
authors.forename: S F
authors.initials: SF
authors.lastname: Wang
authors.affiliation: Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.|Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Shi
authors.affiliation: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.|Shandong Provincial Key Lab for Dermatovenereology, Jinan, Shandong, China.
authors.forename: G Z
authors.initials: GZ
authors.lastname: Zhou
authors.affiliation: Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.|Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.|National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong, China.
authors.forename: H Q
authors.initials: HQ
authors.lastname: Tian
authors.affiliation: Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.|Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.|Shandong Provincial Key Lab for Dermatovenereology, Jinan, Shandong, China.|National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong, China.
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.affiliation: Shandong Clinical College of Skin Diseases, Anhui Medical University, Jinan, Shandong, China.|Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China.|Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, 27397 Jingshi Road, Jinan, Shandong, 250022, China.|Shandong Provincial Key Lab for Dermatovenereology, Jinan, Shandong, China.|National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong, China.
authors.forename: F R
authors.initials: FR
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001203:Ascomycota; D053468:CARD Signaling Adaptor Proteins / Q000172:deficiency / Q000235:genetics*; D003881:Dermatomycoses / Q000235:genetics*; D005148:Facial Dermatoses / Q000235:genetics*; D005260:Female; D006801:Humans; D009154:Mutation / Q000235:genetics*
chemical_list: D053468:CARD Signaling Adaptor Proteins; C505855:CARD9 protein, human