title: Mouse Sensitivity is an Independent Risk Factor for Rhinitis in Children with Asthma.
abstract: BACKGROUND
  Although mouse and cockroach allergy is known to be important in urban children with asthma, the independent association of mouse and cockroach sensitization with rhinitis in these children is unknown.
  
  
  OBJECTIVE
  To determine the association of mouse and cockroach sensitization with rhinitis in urban children with asthma.
  
  
  METHODS
  As part of the Mouse Allergen and Asthma Intervention Trial, 499 urban children (5-17 years) with persistent asthma underwent spirometry, skin prick testing to 14 common environmental allergens, and serology for mouse-specific IgE. In 269 subjects, cockroach-specific IgE serology was also obtained. Patient/parent-reported rhinitis in the last 2 weeks and the last 1 year was the primary outcome measure. Mouse/cockroach exposure was measured by reported frequency of sightings. Mouse allergen-settled bedroom dust samples were also measured in mouse-sensitized children.
  
  
  RESULTS
  Rhinitis was reported in 49.9% and 70.2% of the participants within the last 2 weeks and the last 1 year, respectively. Serum mouse IgE level of 0.35 IU/mL or more was associated with rhinitis in the past 2 weeks (adjusted odds ratio, 2.15; 95% CI, 1.02-4.54; P = .04) and the past 1 year (adjusted odds ratio, 2.40; 95% CI, 1.12-5.1; P = .02) after controlling for age, race, sex, the presence of any smokers at home, primary caregiver education level, number of allergen sensitivities, cockroach IgE level of 0.35 IU/mL or more, and study site (Boston or Baltimore). Measures of home mouse exposure were not associated with rhinitis, regardless of mouse sensitivity. Cockroach sensitivity was not associated with rhinitis regardless of sensitization to other allergens.
  
  
  CONCLUSIONS
  In urban children with asthma, increased mouse IgE, but not cockroach IgE, in the sera (mouse IgE ≥ 0.35 IU/mL) may be associated independently with rhinitis.
authors.affiliation: Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Mass; Department of Otolaryngology and Communications Enhancement, Boston Children's Hospital, Boston, Mass; Department of Otology and Laryngology, Harvard Medical School, Boston, Mass.
authors.forename: Ahmad R
authors.initials: AR
authors.lastname: Sedaghat
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Md.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Matsui
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Sachin N
authors.initials: SN
authors.lastname: Baxi
authors.affiliation: Division of Pulmonology and Allergy, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Md.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Bollinger
authors.affiliation: Division of Pulmonary, Allergy, Critical Care Medicine, Columbia University Medical Center, New York, NY; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY.
authors.forename: Rachel
authors.initials: R
authors.lastname: Miller
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY.
authors.forename: Matthew
authors.initials: M
authors.lastname: Perzanowski
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address: wanda.phipatanakul@childrens.harvard.edu.
authors.forename: Wanda
authors.initials: W
authors.lastname: Phipatanakul
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003058:Cockroaches / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D019476:Insect Proteins / Q000276:immunology; D008297:Male; D051379:Mice / Q000276:immunology; D065631:Rhinitis, Allergic / Q000175:diagnosis* / Q000276:immunology; D012306:Risk; D012882:Skin Tests; D013147:Spirometry; D014505:Urban Population
chemical_list: D000485:Allergens; D019476:Insect Proteins; D007073:Immunoglobulin E
keywords: Allergy; Asthma; IgE; Mouse; Pediatric; Rhinitis; Risk factor