title: Gene Positioning Effects on Expression in Eukaryotes.
abstract: The packaging and organization of the genome within the eukaryotic interphase nucleus directly influence how the genes are expressed. An underappreciated aspect of genome structure is that it is highly dynamic and that the physical positioning of a gene can impart control over its transcriptional status. In this review, we assess the current knowledge of how gene positioning at different levels of genome organization can directly influence gene expression during interphase. The levels of organization discussed include chromatin looping, topologically associated domains, chromosome territories, and nuclear compartments. We discuss specific studies demonstrating that gene positioning is a dynamic and highly regulated feature of the eukaryotic genome that allows for the essential spatiotemporal regulation of genes.
authors.affiliation: Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755; email: giovanni.bosco@dartmouth.edu.
authors.forename: Huy Q
authors.initials: HQ
authors.lastname: Nguyen
authors.affiliation: Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755; email: giovanni.bosco@dartmouth.edu.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bosco
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002875:Chromosomes; D056890:Eukaryota / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology*; D023061:Gene Order; D006801:Humans; D007399:Interphase / Q000235:genetics
chemical_list: D002843:Chromatin
keywords: chromatin looping; nuclear organization; transcription