title: Association of FCGR2A p.R131H and CCL2 c.-2518 A>G gene variants with thrombocytopenia in patients with dengue virus infection.
abstract: FCGR2A and CCL2 gene variants are important in dengue pathogenesis and were investigated in 122 dengue patients (DENs) [89 dengue fever (DF) and 33 dengue hemorrhagic fever (DHF)] and 107 healthy controls (HCs) to find out their association with severity of dengue. Genotype frequencies of FCGR2A p.R131H and CCL2 c.-2518 A > G polymorphisms were not different between DF, DHF and HC. Significantly higher frequency of R/R genotype of FCGR2A p.R131H was observed in DEN cases with thrombocytopenia (TP) while the G/G genotype of CCL2 c.-2518 A > G was observed only in DEN cases with TP (p < 0.005). These results suggest that FCGR2A and CCL2 gene variants were associated with the risk of TP in dengue infections.
authors.affiliation: Dengue/Chikungunya Group, National Institute of Virology, 20A, Dr. Ambedkar Road, Pune 411001, India. Electronic address: alagarasu@gmail.com.
authors.forename: Kalichamy
authors.initials: K
authors.lastname: Alagarasu
authors.affiliation: Dengue/Chikungunya Group, National Institute of Virology, 20A, Dr. Ambedkar Road, Pune 411001, India.
authors.forename: Rupali V
authors.initials: RV
authors.lastname: Bachal
authors.affiliation: Dengue/Chikungunya Group, National Institute of Virology, 20A, Dr. Ambedkar Road, Pune 411001, India.
authors.forename: Indraneel
authors.initials: I
authors.lastname: Damle
authors.affiliation: Dengue/Chikungunya Group, National Institute of Virology, 20A, Dr. Ambedkar Road, Pune 411001, India.
authors.forename: Paresh S
authors.initials: PS
authors.lastname: Shah
authors.affiliation: Dengue/Chikungunya Group, National Institute of Virology, 20A, Dr. Ambedkar Road, Pune 411001, India.
authors.forename: Dayaraj
authors.initials: D
authors.lastname: Cecilia
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D003715:Dengue / Q000150:complications* / Q000235:genetics; D003716:Dengue Virus; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D019595:Severe Dengue / Q000150:complications / Q000235:genetics; D013921:Thrombocytopenia / Q000209:etiology*; D055815:Young Adult
chemical_list: D018932:Chemokine CCL2; C445323:FCGR2A protein, human; D017452:Receptors, IgG
keywords: CCL2; Dengue; Dengue fever; Dengue hemorrhagic fever; FCGR2A; Gene polymorphisms; Thrombocytopenia