title: A simple and non-contact optical imaging probe for evaluation of corneal diseases.
abstract: Non-contact imaging techniques are preferred in ophthalmology. Corneal disease is one of the leading causes of blindness worldwide, and a possible way of detection is by analyzing the shape and optical quality of the cornea. Here, a simple and cost-effective, non-contact optical probe system is proposed and illustrated. The probe possesses high spatial resolutions and is non-dependent on coupling medium, which are significant for a clinician and patient friendly investigation. These parameters are crucial, when considering an imaging system for the objective diagnosis and management of corneal diseases. The imaging of the cornea is performed on ex vivo porcine samples and subsequently on small laboratory animals, in vivo. The clinical significance of the proposed study is validated by performing imaging of the New Zealand white rabbit's cornea infected with Pseudomonas.
authors.affiliation: Center for Optical and Laser Engineering, School of MAE, Nanyang Technological University, Singapore 639798.
authors.forename: Xun Jie Jeesmond
authors.initials: XJ
authors.lastname: Hong
authors.affiliation: Center for Optical and Laser Engineering, School of MAE, Nanyang Technological University, Singapore 639798.
authors.forename: V K
authors.initials: VK
authors.lastname: Shinoj
authors.affiliation: Center for Optical and Laser Engineering, School of MAE, Nanyang Technological University, Singapore 639798.
authors.forename: V M
authors.initials: VM
authors.lastname: Murukeshan
authors.affiliation: Singapore Eye Research Institute (SERI) and Singapore National Eye Center (SNEC), 11 Third Hospital Avenue, Singapore 168751.
authors.forename: M
authors.initials: M
authors.lastname: Baskaran
authors.affiliation: Singapore Eye Research Institute (SERI) and Singapore National Eye Center (SNEC), 11 Third Hospital Avenue, Singapore 168751.
authors.forename: T
authors.initials: T
authors.lastname: Aung
mesh_terms: D000818:Animals; D003316:Corneal Diseases / Q000175:diagnosis*; D013552:Swine; D041623:Tomography, Optical Coherence / Q000295:instrumentation*