title: Comparative Analysis of Calcium-Binding Myeloid-Related Protein-8/14 in Saliva and Serum of Patients With Periodontitis and Healthy Individuals.
abstract: BACKGROUND
  This study aims to investigate calcium-binding myeloid-related protein (MRP)-8/14 in the saliva and serum of individuals with periodontitis and periodontally healthy individuals for the assessment of its role in the pathogenesis and clinical diagnosis of periodontitis.
  
  
  METHODS
  This cross-sectional study includes 56 patients with periodontitis and 44 periodontally healthy individuals. Saliva and serum were collected for the detection of MRP-8/14 and calcium levels. Periodontopathic bacteria were determined by polymerase chain reaction in saliva. Correlations between salivary and serum MRP-8/14 levels and clinical parameters, bacteria, and calcium were analyzed with Pearson correlation in a multiple regression model. MRP-8/14 levels were documented with receiver operating characteristic (ROC) curves.
  
  
  RESULTS
  Compared with healthy individuals, MRP-8/14 levels were significantly higher in both the saliva and serum of patients with periodontitis, but calcium was increased only in saliva. A high diagnostic potential of salivary MRP-8/14 was detected for periodontitis (ROC = 0.86). Salivary MRP-8/14 levels correlated significantly with the presence of the periodontopathogen Treponema denticola, as well as with the clinical parameters of periodontitis.
  
  
  CONCLUSIONS
  MRP-8/14 in saliva might be a potential diagnostic parameter for periodontal disease.
authors.affiliation: Division of Conservative Dentistry and Periodontology, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria.|Competence Center for Periodontal Research, Bernhard Gottlieb School of Dentistry, Medical University of Vienna.
authors.forename: Hady
authors.initials: H
authors.lastname: Haririan
authors.affiliation: Division of Conservative Dentistry and Periodontology, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria.|Competence Center for Periodontal Research, Bernhard Gottlieb School of Dentistry, Medical University of Vienna.
authors.forename: Oleh
authors.initials: O
authors.lastname: Andrukhov
authors.affiliation: Department of Medical Statistics, Medical University of Vienna.
authors.forename: Eleonore
authors.initials: E
authors.lastname: Pablik
authors.affiliation: Clinical Research Center, Greiner Bio-One, Kremsmuenster, Austria.
authors.forename: Michaela
authors.initials: M
authors.lastname: Neuhofer
authors.affiliation: Division of Conservative Dentistry and Periodontology, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Moritz
authors.affiliation: Division of Conservative Dentistry and Periodontology, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria.|Competence Center for Periodontal Research, Bernhard Gottlieb School of Dentistry, Medical University of Vienna.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Rausch-Fan
mesh_terms: D002118:Calcium; D055113:Chronic Periodontitis; D003430:Cross-Sectional Studies; D006801:Humans; D010518:Periodontitis; D012463:Saliva; D048373:Treponema denticola
chemical_list: D002118:Calcium
keywords: Biological markers; calcium; calcium-binding proteins; leukocyte L1 antigen complex; periodontitis; saliva