title: BMP10 inhibited the growth and migration of gastric cancer cells.
abstract: Bone morphogenetic protein 10 (BMP10), a novel member of BMP family, has been identified as an important regulator for angiogenesis. Dysregulation of BMP has been observed in several cancer types. However, its roles in gastric cancer (GC) remain unknown. In this study, the expression of BMP10 was found to be down-regulated in GC samples. Forced expression of BMP10 in GC cells inhibited its growth and migration, while knocking down the expression of BMP10 in GC cells promoted cell growth, migration, and metastasis. BMP10 was shown to negatively regulated beta-catenin/TCF signaling by up-regulating Axin protein level. Taken together, the present study revealed the suppressive function of BMP10 in gastric cancer.
authors.affiliation: Department of Clinical Medicine, Yancheng Institute of Health Sciences, No. 263, South Jiefang Road, Yancheng, 224005, Jiangsu, China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Lei
authors.affiliation: Department of Gastrointestinal Surgery, Huai'an Hospital Affiliated of Xuzhou Medical College and Huai'an Second People's Hospital, No. 62, Huai-hai South Road, Huai'an, 223002, Jiangsu, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu, China.
authors.forename: Peihua
authors.initials: P
authors.lastname: Lu
authors.affiliation: Department of Clinical Medicine, Yancheng Institute of Health Sciences, No. 263, South Jiefang Road, Yancheng, 224005, Jiangsu, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Si
authors.affiliation: Department of Clinical Medicine, Yancheng Institute of Health Sciences, No. 263, South Jiefang Road, Yancheng, 224005, Jiangsu, China.
authors.forename: Koulan
authors.initials: K
authors.lastname: Han
authors.affiliation: Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu, China.
authors.forename: Tingyan
authors.initials: T
authors.lastname: Ruan
authors.affiliation: Department of Critical Care Medicine, Affiliated Yixing People's Hospital, Jiangsu University, No. 75, Tongzhenguan Road, Yixing, 214200, Jiangsu, China. lujunjie0723@sina.com.
authors.forename: Junjie
authors.initials: J
authors.lastname: Lu
mesh_terms: D019485:Bone Morphogenetic Proteins / Q000032:analysis / Q000502:physiology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D009362:Neoplasm Metastasis; D015398:Signal Transduction / Q000502:physiology; D013274:Stomach Neoplasms / Q000473:pathology*; D051820:TCF Transcription Factors / Q000502:physiology; D051176:beta Catenin / Q000502:physiology
chemical_list: C541386:BMP10 protein, human; D019485:Bone Morphogenetic Proteins; C495270:CTNNB1 protein, human; D051820:TCF Transcription Factors; D051176:beta Catenin
keywords: Axin; BMP10; Beta-catenin/TCF signaling; Cell growth and migration