title: Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts.
abstract: Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors.
authors.affiliation: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Chen
authors.affiliation: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC.
authors.forename: Ying-Pin
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Lin
authors.affiliation: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC; Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Yaw-Bin
authors.initials: YB
authors.lastname: Huang
authors.affiliation: Graduate Institute of Nature Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Tsai-Hui
authors.initials: TH
authors.lastname: Duh
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Deng-Chyang
authors.initials: DC
authors.lastname: Wu
authors.affiliation: Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors.forename: Wei-Chiang
authors.initials: WC
authors.lastname: Wu
authors.affiliation: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Kao
authors.affiliation: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC.
authors.forename: Pei-Hua
authors.initials: PH
authors.lastname: Yang
mesh_terms: D045744:Cell Line, Tumor; D028481:Euphorbia / Q000737:chemistry; D005353:Fibronectins / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D021962:Membrane Microdomains / Q000378:metabolism*; D010766:Phosphorylation; D010936:Plant Extracts / Q000494:pharmacology*; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D059748:Proteolysis; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D013274:Stomach Neoplasms; D015533:Transcriptional Activation; D016212:Transforming Growth Factor beta / Q000502:physiology*
chemical_list: D005353:Fibronectins; D010936:Plant Extracts; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D007810:Lanosterol; C062557:euphol