title: Transcriptional Enhancers in the Regulation of T Cell Differentiation.
abstract: The changes in phenotype and function that characterize the differentiation of naïve T cells to effector and memory states are underscored by large-scale, coordinated, and stable changes in gene expression. In turn, these changes are choreographed by the interplay between transcription factors and epigenetic regulators that act to restructure the genome, ultimately ensuring lineage-appropriate gene expression. Here, we focus on the mechanisms that control T cell differentiation, with a particular focus on the role of regulatory elements encoded within the genome, known as transcriptional enhancers (TEs). We discuss the central role of TEs in regulating T cell differentiation, both in health and disease.
authors.affiliation: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, VIC , Australia.
authors.forename: Michelle L T
authors.initials: ML
authors.lastname: Nguyen
authors.affiliation: Monash University Centre for Inflammatory Disease, School of Clinical Sciences at Monash Health , Melbourne, VIC , Australia.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Jones
authors.affiliation: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, VIC , Australia.
authors.forename: Julia E
authors.initials: JE
authors.lastname: Prier
authors.affiliation: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, VIC , Australia.
authors.forename: Brendan E
authors.initials: BE
authors.lastname: Russ
keywords: T cell differentiation; differentiation; epigenetics; transcription factors; transcriptional enhancers