title: Evaluation of High-Performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both In Vitro and In Vivo.
abstract: This paper focused on formulating high-performance curcumin spray-dried powders for inhalation (curcumin-DPIs) to achieve a high lung concentration. Curcumin-DPIs were produced using wet milling combined with the spray drying method. The effects of different milling times on particle size and aerodynamic performance were investigated. The curcumin-DPIs were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and in vitro dissolution. Furthermore, the in vivo pharmacokinetic behavior and tissue distribution after pulmonary administration were also evaluated. Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs. The aerodynamic results indicated that the DPIs displayed a good aerosol performance. The plasma curcumin concentration was obviously enhanced by inhalation, and most of the curcumin-DPIs were deposited in the lung. This study demonstrated that inhalation was an effective way to carry drug to the lung, and curcumin-DPIs were hopeful for lung cancer treatment in the future.
authors.affiliation: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China. hbupharm@126.com.|Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, People's Republic of China. hbupharm@126.com.
authors.forename: Liandong
authors.initials: L
authors.lastname: Hu
authors.affiliation: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China.|Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, People's Republic of China.
authors.forename: Dongqian
authors.initials: D
authors.lastname: Kong
authors.affiliation: CSPC Pharmaceutical Group NBP Pharmaceutical Co. Ltd, Shijiazhuang, People's Republic of China.
authors.forename: Qiaofeng
authors.initials: Q
authors.lastname: Hu
authors.affiliation: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China.|Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Gao
authors.affiliation: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China.|Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, People's Republic of China.
authors.forename: Saixi
authors.initials: S
authors.lastname: Pang
keywords: Curcumin; Nanocrystals; Pulmonary delivery; Tissue distribution; Wet milling