title: Histological and immunohistochemical aspects of papillary thyroid cancer.
abstract: Papillary thyroid carcinoma is one of the most common malignancies of the endocrine system. In recent years, its incidence has increased worldwide, including children, which concerns the entire community. Although the histopathological diagnosis seems rather easy, the existence of particular forms of thyroid cancer and the inclusion of the follicular aspect as a variant of papillary carcinoma lead to diagnostic confusion. Therefore, in the last 20 years were reviewed several immunohistochemical markers, which are useful in the positive and differential diagnosis, and which offer better data on disease prognosis. Our study included a total of 27 cases of papillary carcinomas, which we evaluated the immunohistochemical expression of Ki-67, p53, p63, E-cadherin, CD56, calretinin, and bcl-2 markers. The most intense expression was found in p53, E-cadherin, and bcl-2. Ki-67 and p63 expression were moderate and inconsistent, and CD56 and calretinin had a negative expression in all cases.
authors.affiliation: Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania; laurentiu_mogoanta@yahoo.com.
authors.forename: Tatiana Georgiana
authors.initials: TG
authors.lastname: Radu
authors.forename: Laurenţiu
authors.initials: L
authors.lastname: Mogoantă
authors.forename: Cristina Jana
authors.initials: CJ
authors.lastname: Busuioc
authors.forename: Casiana
authors.initials: C
authors.lastname: Stănescu
authors.forename: Florin
authors.initials: F
authors.lastname: Grosu
mesh_terms: D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000378:metabolism; D019002:CD56 Antigen / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism; D064032:Calbindin 2 / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology*; D002291:Carcinoma, Papillary; D004703:Endocrine System; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D009369:Neoplasms / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*; D014157:Transcription Factors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D015703:Antigens, CD; C000595707:BCL2 protein, human; D014408:Biomarkers, Tumor; D019002:CD56 Antigen; C513384:CDH1 protein, human; D015820:Cadherins; D064032:Calbindin 2; D019394:Ki-67 Antigen; C522918:NCAM1 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; C495901:TP53 protein, human; C115051:TP63 protein, human; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins