title: "PEAR-ing" Genomic and Epigenomic Analyses for Cancer Gene Discovery.
abstract: Somatic structural variants in tumor genomes can deregulate transcription through repositioning of enhancer elements. A new method, PEAR-ChIP, leverages paired-end H3K27ac chromatin immunoprecipitation combined with high-throughput sequencing and current computational methods to identify such events.
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Mack
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
authors.forename: Jeremy N
authors.initials: JN
authors.lastname: Rich
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio. pxs183@case.edu.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Scacheri
mesh_terms: D004742:Enhancer Elements, Genetic; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics*; D009857:Oncogenes