title: Current developments in cell- and biomaterial-based approaches for stroke repair.
abstract: BACKGROUND
  Stroke is one of the most devastating diseases and a leading cause of mortality worldwide. So far, clinical management of stroke involves surgical clot retrieval or thrombolytic treatment inducing reperfusion of the occluded vessels in the cerebral infarcted area, which is dependent on early intervention following insult. New treatment strategies involve the promotion of angiogenesis and neuroplasticity, stimulation of endogenous neurogenesis, remyelinization, and immunomodulation by means of cell transplantation and sustained drug delivery.
  
  
  METHODS
  This review describes different types of stem cells (endogenous and exogenous neural progenitors, pluripotent stem cell derivatives, mesenchymal stem cells [MSCs], olfactory ensheathing cells) and biomaterials, their routes of administration, means of noninvasive imaging, and the prerequisites and hurdles for the successful translation of the cell therapies to the clinic.
  
  
  CONCLUSIONS
  Neural precursors (NPs) derived from pluripotent stem cells, unlike MSCs, can not only remodel the CNS by promoting neuroplasticity, angiogenesis, and immunomodulation, but also replace damaged cells. To transfer NPs into the clinic, step by step guidelines for researchers are identified and discussed.
authors.affiliation: a 1 Institute of Experimental Medicine ASCR, Department of Neuroscience , Prague, Czech Republic +420 2 41 06 22 82 ; +420 2 41 06 27 06 ; jendel@biomed.cas.cz.
authors.forename: Pavla
authors.initials: P
authors.lastname: Jendelová
authors.affiliation: b 2 Institute of Experimental Medicine ASCR, Department of Neuroscience , Prague, Czech Republic.
authors.forename: Šárka
authors.initials: Š
authors.lastname: Kubinová
authors.affiliation: c 3 Norwegian University of Science and Technology, Department of Neuroscience , 7491 Trondheim, Norway.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Sandvig
authors.affiliation: b 2 Institute of Experimental Medicine ASCR, Department of Neuroscience , Prague, Czech Republic.
authors.forename: Slaven
authors.initials: S
authors.lastname: Erceg
authors.affiliation: c 3 Norwegian University of Science and Technology, Department of Neuroscience , 7491 Trondheim, Norway.
authors.forename: Axel
authors.initials: A
authors.lastname: Sandvig
authors.affiliation: b 2 Institute of Experimental Medicine ASCR, Department of Neuroscience , Prague, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Syková
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods* / Q000639:trends*; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology / Q000637:transplantation; D055153:Stem Cell Niche / Q000502:physiology; D020521:Stroke / Q000503:physiopathology / Q000628:therapy*; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials
keywords: clinical trials; ischemic lesion; mesenchymal stem cells; neural progenitors; neurogenesis; noninvasive imaging; stem cells; stroke; translation