title: A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.
abstract: Mouse models provide important resources for many areas of vision research, pertaining to retinal development, retinal function and retinal disease. The Translational Vision Research Models (TVRM) program uses chemical mutagenesis to generate new mouse models for vision research. In this chapter, we report the identification of mouse models for Grm1, Grk1 and Lrit3. Each of these is characterized by a primary defect in the electroretinogram. All are available without restriction to the research community.
authors.affiliation: The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Jeremy.Charette@jax.org.
authors.forename: Jeremy R
authors.initials: JR
authors.lastname: Charette
authors.affiliation: Louis Stokes Cleveland VA Medical Center, 44106, Cleveland, OH, USA. Ivy.Samuels@va.gov.
authors.forename: Ivy S
authors.initials: IS
authors.lastname: Samuels
authors.affiliation: Cole Eye Institute, Cleveland Clinic, 44195, Cleveland, OH, USA. YUM@ccf.org.
authors.forename: Minzhong
authors.initials: M
authors.lastname: Yu
authors.affiliation: The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Lisa.Stone@jax.org.
authors.forename: Lisa
authors.initials: L
authors.lastname: Stone
authors.affiliation: The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Wanda.jordan@jax.org.
authors.forename: Wanda
authors.initials: W
authors.lastname: Hicks
authors.affiliation: The Jackson Laboratory, 04609, Bar Harbor, ME, USA. lanying_shi1234@163.com.
authors.forename: Lan Ying
authors.initials: LY
authors.lastname: Shi
authors.affiliation: The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Mark.Krebs@jax.org.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Krebs
authors.affiliation: The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Juergen.Naggert@jax.org.
authors.forename: Jürgen K
authors.initials: JK
authors.lastname: Naggert
authors.affiliation: The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Nishina@jax.org.
authors.forename: Patsy M
authors.initials: PM
authors.lastname: Nishina
authors.affiliation: Louis Stokes Cleveland VA Medical Center, 44106, Cleveland, OH, USA. peachen@ccf.org.|Cole Eye Institute, Cleveland Clinic, 44195, Cleveland, OH, USA. peachen@ccf.org.|Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. peachen@ccf.org.
authors.forename: Neal S
authors.initials: NS
authors.lastname: Peachey
mesh_terms: D000483:Alleles; D000818:Animals; D004195:Disease Models, Animal; D004596:Electroretinography; D005128:Eye Diseases / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D051606:G-Protein-Coupled Receptor Kinase 1 / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D016296:Mutagenesis; D009154:Mutation; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics; D012160:Retina / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D012164:Retinal Diseases / Q000175:diagnosis / Q000235:genetics*; D057170:Translational Research, Biomedical / Q000379:methods; D014785:Vision, Ocular / Q000235:genetics / Q000502:physiology
chemical_list: C000594373:Lrit3 protein, mouse; D008565:Membrane Proteins; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; D051606:G-Protein-Coupled Receptor Kinase 1; C496762:Grk1 protein, mouse
keywords: Electroretinogram; Mice; Mutagenesis; Photoreceptor; Retina