title: Acidity-Induced Destabilization of Nano-Sized Supramolecular Linear-Hyperbranched Polymersome for Controlled Release of Encapsulated Cargoes.
abstract: This study reports a linear-hyperbranched supramolecular amphiphile and its vesicular nanoassembly with acidity-sensitive susceptibility including volume extension and membrane rupture. Involvement of a host-guest interaction in the amphiphilic construction allows not only facile control of the assembly types (solid and hollow nanoparticles), but also the one-step achievement of both polymersome fabrication and drug encapsulation. The pH-dependency of assembly stability leads to the controlled release of encapsulated hydrophilic agents in an acidity-accelerated manner. By blocking the endosomal acidification progression using NH4 Cl treatment, the lysosomal acid environment is suggested to play an important role in the drug release behavior inside cells and contributes much to nuclei-tropic drug transport.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Dong
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, China.
authors.forename: Hui-zhen
authors.initials: HZ
authors.lastname: Jia
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, China.
authors.forename: Jing-yi
authors.initials: JY
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, China.
authors.forename: Ren-xi
authors.initials: RX
authors.lastname: Zhuo
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Feng
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, China. fengjun@whu.edu.cn.
authors.forename: Xian-zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011992:Endosomes / Q000378:metabolism* / Q000648:ultrastructure; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D003692:Delayed-Action Preparations
keywords: controlled release; host-guest interactions; hyperbranched vesicles; pH-sensitivity; self-assembly