title: Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies.
abstract: Thyroid autoimmunity with normal thyroid function is associated with recurrent miscarriage (RM), but the association with live birth is less clear. Therefore, we determined the association between thyroid peroxidase antibodies (TPO-Ab) and live-birth rate (LBR) in a retrospective cohort of euthyroid women with unexplained RM. We included 202 women of which 28 were TPO-Ab positive (13.9%) and 174 were TPO-Ab negative. TPO-Ab positive women (n = 10) without levothyroxine treatment had a lower LBR (29%) compared to TPO-Ab negative women (51%) (HR 0.23, 0.07-0.72, p = 0.012). The LBR in women with TPO-Ab receiving levothyroxine was not different compared women without TPO-Ab (60% versus 51%, p = 0.50). In conclusion, TPO-Ab are associated with a lower LBR in euthyroid women with unexplained RM and these women may benefit from treatment with levothyroxine.
authors.affiliation: a Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, The Netherlands .
authors.forename: Rosa
authors.initials: R
authors.lastname: Vissenberg
authors.affiliation: b Department of Endocrinology and Metabolism , Academic Medical Center, University of Amsterdam , The Netherlands , and.
authors.forename: Eric
authors.initials: E
authors.lastname: Fliers
authors.affiliation: c Department of Obstetrics and Gynecology , Academic Medical Center, University of Amsterdam , The Netherlands.
authors.forename: Joris A M
authors.initials: JA
authors.lastname: van der Post
authors.affiliation: a Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, The Netherlands .
authors.forename: Madelon
authors.initials: M
authors.lastname: van Wely
authors.affiliation: b Department of Endocrinology and Metabolism , Academic Medical Center, University of Amsterdam , The Netherlands , and.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Bisschop
authors.affiliation: a Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, The Netherlands .
authors.forename: Mariette
authors.initials: M
authors.lastname: Goddijn
mesh_terms: D000026:Abortion, Habitual / Q000097:blood*; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D033862:Iron-Binding Proteins / Q000276:immunology*; D050498:Live Birth; D011247:Pregnancy; D012189:Retrospective Studies; D013974:Thyroxine / Q000627:therapeutic use*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D033862:Iron-Binding Proteins; C056658:TPO protein, human; D007453:Iodide Peroxidase; D013974:Thyroxine
keywords: Levothyroxine; live-birth rate; pregnancy rate; recurrent miscarriage; thyroid autoimmunity; thyroid peroxidase antibodies