title: Curcumin inhibits bovine herpesvirus type 1 entry into MDBK cells.
abstract: The generation of antiviral drugs from herbs and other natural resources with traditionally long-confirmed effects is an efficient approach. So far, no herb or components from herbs that could inhibit bovine herpesvirus type 1 (BoHV-1) replication have been described. In this study, the antiviral effect of curcumin, a natural phenolic constituent of the spice turmeric, on BoHV-1 replication was evaluated in cell culture. We demonstrated that curcumin impairs BoHV-1 viral particles and affects the virus post-binding entry process. Furthermore, curcumin upregulated the proportion of the plasma membrane adopting a lipid raft conformation in MDBK cells, which supported the previous reports that curcumin can modulate the lipid bilayer. Though the antiviral mechanism of curcumin on BoHV-1 needs further study, we identified for the first time a component from herb that could inhibit BoHV-1 replication, in vitro.
authors.forename: L
authors.initials: L
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Ding
authors.forename: D
authors.initials: D
authors.lastname: Zhang
authors.forename: Ch
authors.initials: Ch
authors.lastname: Yuan
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: E
authors.initials: E
authors.lastname: Ndegwa
authors.forename: G
authors.initials: G
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D003474:Curcumin / Q000494:pharmacology*; D007242:Herpesvirus 1, Bovine / Q000187:drug effects* / Q000502:physiology; D021962:Membrane Microdomains / Q000187:drug effects; D053586:Virus Internalization / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D003474:Curcumin
keywords: BoHV-1; curcumin; lipid raft; virus entry.