title: Mean platelet volume is elevated in exacerbated and convalescent COPD patients.
abstract: BACKGROUND
  Mean platelet volume (MPV), reflecting the platelet production rate and stimulation, is an inflammatory marker for cardiovascular disease, inflammatory bowel disease, and rheumatoid arthritis. However, the associations between MPV and chronic obstructive pulmonary disease (COPD) are not in agreement.
  
  
  METHODS
  Ninety participants with an exacerbation of COPD were investigated, and were reassessed when convalescent. Ninety controls were matched for age, gender, body mass index, smoking index, and medication use. Blood samples were collected for measurements of MPV and other laboratory data, and pulmonary function was also assessed.
  
  
  RESULTS
  MPV is significantly increased in convalescent COPD patients compared with healthy controls, and further increased in COPD patients with an acute exacerbation. MPV was positively correlated with high-sensitivity C-reactive protein both in the exacerbation and convalescence periods of COPD, and negatively correlated with FEV1 % predicted and FEV1/FVC in the convalescent COPD patients.
  
  
  CONCLUSIONS
  MPV may be regarded as a quick and reliable tool in the assessment of inflammatory response in the progression of COPD.
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: zhangmingdr@163.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Shan
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Qingzhi
authors.initials: Q
authors.lastname: Jin
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Xiangli
authors.initials: X
authors.lastname: Feng
mesh_terms: D003289:Convalescence; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000188:drug therapy; D012129:Respiratory Function Tests
keywords: C-reactive protein; Chronic obstructive pulmonary disease; Inflammation; Mean platelet volume; Pulmonary function