title: Sleeve Gastrectomy Reduces Body Weight and Improves Metabolic Profile also in Obesity-Prone Rats.
abstract: Susceptibility to obesity is associated with a notable inter-individual variation. The aim of the present study was to compare the effectiveness of sleeve gastrectomy (SG) on weight loss and metabolic profile in obesity-prone (OP) rats vs animals that are non-susceptible to obesity (NSO).
  
  
  
  Young male Wistar rats (n = 101) were put in a diet-induced obesity (DIO) programme with ad libitum access to a high-fed diet (HFD) during 12 months. Body weight and food intake were regularly registered. Thereafter, rats were ranked by final body weight to identify the obesity-prone (OP) (n = 13) and non-susceptible to obesity (NSO) (n = 14) animals. OP and NSO rats were submitted to surgical interventions (sham operation, SG and pair-fed to the amount of food eaten by sleeve-gastrectomized rats). Body weight, food intake, energy expenditure, body temperature, fat pads weight, and metabolic profiling were analysed 4 weeks after surgical or dietary interventions.
  
  
  
  SG in both OP and NSO rats decreased body weight as compared to sham and pair-fed groups (P < 0.05), mainly due to reductions in subcutaneous and perirenal fat mass (P < 0.001). Total weight loss achieved in sleeve-gastrectomized OP and NSO rats was higher than that of pair-fed ones (P < 0.05), showing that the SG effect goes beyond caloric restriction. In this regard, sleeve-gastrectomized rats exhibited significantly (P < 0.05) increased basal rectal temperature together with upregulated brown adipose tissue Ucp-1 protein expression levels. A significant (P < 0.05) improvement in insulin sensitivity was also observed in both OP and NSO animals that underwent SG as compared with pair-fed counterparts.
  
  
  
  Our findings provide the first evidence that obesity-prone rats also benefit from surgery responding effectively to SG, as evidenced by the significant body weight reduction and the metabolic profile improvement.
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Department of Anesthesia, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Moncada
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Becerril
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Amaia
authors.initials: A
authors.lastname: Rodríguez
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Leire
authors.initials: L
authors.lastname: Méndez-Giménez
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Ramírez
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Catalán
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Gómez-Ambrosi
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Department of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: M Jesús
authors.initials: MJ
authors.lastname: Gil
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Department of Otorhinolaryngology, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Secundino
authors.initials: S
authors.lastname: Fernández
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Javier A
authors.initials: JA
authors.lastname: Cienfuegos
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.|Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Valentí
authors.affiliation: CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain. gfruhbeck@unav.es.|Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain. gfruhbeck@unav.es.|Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain. gfruhbeck@unav.es.|Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, Avda. Pío XII, 36, 31008, Pamplona, Spain. gfruhbeck@unav.es.
authors.forename: Gema
authors.initials: G
authors.lastname: Frühbeck
mesh_terms: D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000378:metabolism*; D005743:Gastrectomy; D008297:Male; D055442:Metabolome; D009765:Obesity / Q000378:metabolism* / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D015431:Weight Loss
keywords: Diet-induced obesity; Obesity phenotypes; Obesity-prone; Sleeve gastrectomy; Susceptibility