title: Replacement of the aortic valve with a bioprosthesis at the time of continuous flow ventricular assist device implantation for preexisting aortic valve dysfunction.
abstract: Left ventricular assist device (LVAD) implantation has become a mainstay of therapy for advanced heart failure patients who are either ineligible for, or awaiting, cardiac transplantation. Controversy remains over the optimal therapeutic strategy for preexisting aortic valvular dysfunction in these patients at the time of LVAD implant. In patients with moderate to severe aortic regurgitation, surgical approaches are center specific and range from variable leaflet closure techniques to concomitant aortic valve replacement (AVR) with a bioprosthesis. In the present study, we retrospectively analyzed our outcomes in patients who underwent simultaneous AVR and LVAD implantation secondary to antecedent aortic valve pathology. Between January 2004 and June 2010, 144 patients underwent LVAD implantation at a single institution. Of these, 7 patients (4.8%) required concomitant AVR. Five of the 7 patients (71%) survived to hospital discharge and suffered no adverse events in the perioperative period. One-year survival for the discharged patients was 80%, and no prosthetic valve-related adverse events were observed in long-term follow-up. Given our experience, we conclude that bioprosthetic AVR is a plausible alternative for end-stage heart failure patients at the time of LVAD implantation.
authors.affiliation: Department of Cardiac Surgery, Baylor University Medical Center at Dallas, Dallas, Texas (Lima, Chamogeorgakis), and the Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio (Mountis, Gonzalez-Stawinski). Dr. Gonzalez-Stawinski is now affiliated with Baylor University Medical Center at Dallas.
authors.forename: Brian
authors.initials: B
authors.lastname: Lima
authors.affiliation: Department of Cardiac Surgery, Baylor University Medical Center at Dallas, Dallas, Texas (Lima, Chamogeorgakis), and the Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio (Mountis, Gonzalez-Stawinski). Dr. Gonzalez-Stawinski is now affiliated with Baylor University Medical Center at Dallas.
authors.forename: Themistokles
authors.initials: T
authors.lastname: Chamogeorgakis
authors.affiliation: Department of Cardiac Surgery, Baylor University Medical Center at Dallas, Dallas, Texas (Lima, Chamogeorgakis), and the Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio (Mountis, Gonzalez-Stawinski). Dr. Gonzalez-Stawinski is now affiliated with Baylor University Medical Center at Dallas.
authors.forename: Maria
authors.initials: M
authors.lastname: Mountis
authors.affiliation: Department of Cardiac Surgery, Baylor University Medical Center at Dallas, Dallas, Texas (Lima, Chamogeorgakis), and the Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio (Mountis, Gonzalez-Stawinski). Dr. Gonzalez-Stawinski is now affiliated with Baylor University Medical Center at Dallas.
authors.forename: Gonzalo V
authors.initials: GV
authors.lastname: Gonzalez-Stawinski