title: Guiding dengue vaccine development using knowledge gained from the success of the yellow fever vaccine.
abstract: Flaviviruses comprise approximately 70 closely related RNA viruses. These include several mosquito-borne pathogens, such as yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), which can cause significant human diseases and thus are of great medical importance. Vaccines against both YFV and JEV have been used successfully in humans for decades; however, the development of a DENV vaccine has encountered considerable obstacles. Here, we review the protective immune responses elicited by the vaccine against YFV to provide some insights into the development of a protective DENV vaccine.
authors.affiliation: Viral Disease and Vaccine Translational Research Unit, and Vaccine Centre, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Huabin
authors.initials: H
authors.lastname: Liang
authors.affiliation: Viral Disease and Vaccine Translational Research Unit, and Vaccine Centre, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Min
authors.initials: M
authors.lastname: Lee
authors.affiliation: Viral Disease and Vaccine Translational Research Unit, and Vaccine Centre, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Jin
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology / Q000821:virology; D003715:Dengue / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D053059:Dengue Vaccines / Q000008:administration & dosage* / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D003716:Dengue Virus / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000821:virology; D010802:Phylogeny; D020365:RNA Helicases / Q000235:genetics / Q000276:immunology; D012697:Serine Endopeptidases / Q000235:genetics / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000276:immunology; D014779:Virus Replication / Q000187:drug effects; D015004:Yellow Fever / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D022341:Yellow Fever Vaccine / Q000008:administration & dosage* / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D015005:Yellow fever virus / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000276:immunology*; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D000914:Antibodies, Viral; D016207:Cytokines; D053059:Dengue Vaccines; D020365:RNA Helicases; D012697:Serine Endopeptidases; D017361:Viral Nonstructural Proteins; D022341:Yellow Fever Vaccine; C080102:NS2B protein, flavivirus; C060028:NS3 protein, flavivirus; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases