title: Epithelial-Mesenchymal Transition Protein Expression in Basal Cell Adenomas and Basal Cell Adenocarcinomas.
abstract: Basal cell adenomas and basal cell adenocarcinomas show marked histomorphologic similarity and are separated microscopically primarily by the invasive characteristics of the adenocarcinomas. We wished to explore potential differences in the expression of epithelial-mesenchymal transition associated proteins in these two tumor types. A tissue microarray was constructed utilizing 29 basal cell adenomas and 16 basal cell adenocarcinomas. Immunohistochemical expression of E-cadherin, beta-catenin, Twist 1 and vimentin were investigated. Both tumors expressed all proteins in a relatively similar manner. Nuclear beta-catenin was essentially limited to the abluminal cell populations in both tumor types. E-cadherin was limited largely to luminal locations but was more prevalent in the adenocarcinomas as compared to the adenomas. Primarily abluminal expression for vimentin was seen, sometimes present in an apical dot-like pattern. Distinct populations of cellular expression of these four markers of epithelial mesenchymal transition were present but were similar in locations in both tumors with no patterns discerned to separate basal cell adenoma from basal cell adenocarcinoma. Given these findings, the mechanisms by which basal cell adenocarcinoma is able to invade while its counterpart, basal cell adenoma can not, may be more complex than in other tumor types.
authors.affiliation: Department of Pathology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 5238H RCP, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
authors.forename: Brennan A
authors.initials: BA
authors.lastname: Tesdahl
authors.affiliation: Department of Pathology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 5238H RCP, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wilson
authors.affiliation: Department Otolaryngology-Head and Neck Surgery, Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
authors.forename: Henry T
authors.initials: HT
authors.lastname: Hoffman
authors.affiliation: Department of Pathology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 5238H RCP, 200 Hawkins Drive, Iowa City, IA, 52242, USA. robert-a-robinson@uiowa.edu.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Robinson
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000032:analysis; D015820:Cadherins / Q000032:analysis; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D046888:Tissue Array Analysis; D051879:Twist-Related Protein 1 / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D051176:beta Catenin / Q000032:analysis
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D051879:Twist-Related Protein 1; D014746:Vimentin; D051176:beta Catenin
keywords: Basal cell adenocarcinoma; Basal cell adenoma; Beta-catenin; E-cadherin; Twist 1; Vimentin