title: The diagnostic utility of scintigraphy in esophageal burn: a rat model.
abstract: BACKGROUND
  Corrosive esophageal injury due to accidental ingestion is a serious clinical problem in children particularly in developing countries. The present study was conducted to evaluate the diagnostic utility of technetium-99m-pyrophosphate ((99m)Tc-PYP) scintigraphy in the early stage of esophageal burns by using different concentrations of sodium hydroxide (NaOH) in an experimental rat model.
  
  
  METHODS
  Twenty-eight male Sprague-Dawley rats, weighing 200-250 g, were used in the study. Esophageal burn model was created in 21 rats by gastrically infusion of various concentrations of NaOH. The rats were divided randomly into three groups: mild-burn group (n = 7) received 15% NaOH, moderate-burn group (n = 7) received 30% NaOH and severe-burn group (n = 7) received 45% NaOH. Seven rats were identified as control group and received normal saline. Three hours after burn injury, 1-mCi (99m)Tc-PYP was administered through tail vein. Two hours after (99m)Tc-PYP administration, static imaging with gamma camera was performed. Then, histopathologic assessment of esophageal samples was achieved properly.
  
  
  RESULTS
  All NaOH-applied groups (mild, moderate, and severe) showed a significant higher uptake ratio when compared to control group (P < 0.005). NaOH-applied groups displayed important histologic alterations such as mucosal disintegration, edema, inflammation, and stromal damage when compared to control group. Pearson correlation analysis revealed a significant correlation between the (99m)Tc-PYP uptake ratio and histologic score (P < 0.0005).
  
  
  CONCLUSIONS
  The scintigraphic imaging may provide advantages in the early stage of esophageal burns in some patients whom endoscopic procedure is contraindicated because of its high risk of complications such as bleeding and perforation.
authors.affiliation: Department of Nuclear Medicine, Gaziosmanpaşa University School of Medicine, Tokat, Turkey.
authors.forename: Öznur Dilek
authors.initials: ÖD
authors.lastname: Çiftçi
authors.affiliation: Department of Nuclear Medicine, Gaziosmanpaşa University School of Medicine, Tokat, Turkey.
authors.forename: Serdar Savaş
authors.initials: SS
authors.lastname: Gül
authors.affiliation: Department of Emergency Medicine, Istanbul Bilim University School of Medicine, Istanbul, Turkey.
authors.forename: Kurtuluş
authors.initials: K
authors.lastname: Açıksarı
authors.affiliation: Department of Nuclear Medicine, Tokat State Hospital, Tokat, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Maman
authors.affiliation: Department of Histology and Embryology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Türker
authors.initials: T
authors.lastname: Çavuşoğlu
authors.affiliation: Department of General Surgery, Istanbul Bilim University School of Medicine, Istanbul, Turkey.
authors.forename: Refik
authors.initials: R
authors.lastname: Bademci
authors.affiliation: Department of Physiology, Ege University School of Medicine, Izmir, Turkey. Electronic address: dilek.taskiran@ege.edu.tr.
authors.forename: Dilek
authors.initials: D
authors.lastname: Taskiran
authors.affiliation: Department of Physiology, Istanbul Bilim University School of Medicine, Istanbul, Turkey.
authors.forename: Oytun
authors.initials: O
authors.lastname: Erbaş
mesh_terms: D000818:Animals; D002057:Burns, Chemical / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D002424:Caustics / Q000633:toxicity*; D004947:Esophagus / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012972:Sodium Hydroxide / Q000633:toxicity*; D016698:Technetium Tc 99m Pyrophosphate
chemical_list: D002424:Caustics; D019275:Radiopharmaceuticals; D012972:Sodium Hydroxide; D016698:Technetium Tc 99m Pyrophosphate
keywords: Caustic injury; Caustic substance; Endoscopy; Esophagitis; Technesium 99m scintigraphy