title: Effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children: A randomized controlled trial.
abstract: OBJECTIVE
  To examine the effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children.
  
  
  METHODS
  One hundred and fifteen children were recruited in Odense, Denmark (2012-2014). The participants were randomly allocated to either the day camp intervention arm (DCIA) or the standard intervention arm (SIA). The intervention for the DCIA consisted of a 6-week camp-based intervention and a 46-week family-based intervention. The SIA was offered one weekly physical activity session for 6 weeks and one educational meeting. C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP1), leptin, and adiponectin were measured in serum at baseline, 6 weeks and 52 weeks.
  
  
  RESULTS
  In comparison with the SIA, the reductions in CRP (P=0.003) and leptin (p<0.001) were larger in the DCIA at 6 weeks. The intervention effects on leptin were significantly mediated by the changes in body fat mass. No intervention effects on CRP and leptin were seen at 52 weeks. No between-group differences in changes in MCP1 and adiponectin were observed at 6 weeks or 52 weeks.
  
  
  CONCLUSIONS
  The 6-week camp intervention resulted in reductions in CRP and leptin. The intervention effects did not persist to 52 weeks. The intervention effect on leptin was explained by changes in body fat mass.
authors.affiliation: Center of Research in Childhood Health (RICH), Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. Electronic address: thuang@health.sdu.dk.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: Center of Research in Childhood Health (RICH), Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
authors.forename: Kristian Traberg
authors.initials: KT
authors.lastname: Larsen
authors.affiliation: Center of Research in Childhood Health (RICH), Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
authors.forename: Niels Christian
authors.initials: NC
authors.lastname: Møller
authors.affiliation: The Center of Inflammation and Metabolism (CIM) and The Center for Physical Activity Research (CFAS) at Rigshospitalet, Copenhagen, The Danish Diabetes Academy, Odense, Denmark.
authors.forename: Mathias
authors.initials: M
authors.lastname: Ried-Larsen
authors.affiliation: SDU Muscle Research Cluster (SMRC), Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Frandsen
authors.affiliation: Center of Research in Childhood Health (RICH), Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
authors.forename: Lars Bo
authors.initials: LB
authors.lastname: Andersen
mesh_terms: D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002165:Camping; D018932:Chemokine CCL2 / Q000097:blood*; D002648:Child; D003718:Denmark; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000628:therapy; D013997:Time Factors; D061217:Weight Reduction Programs
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D020738:Leptin; D002097:C-Reactive Protein
keywords: Adipokines; Children; Inflammatory markers; Low-grade inflammation; Obesity