title: Adiponectin, leptin and IL-1 β in elderly diabetic patients with mild cognitive impairment.
abstract: The aim of the study was to determine the serum levels of adiponectin, leptin and IL-1 β in elderly diabetic patients with and without mild cognitive impairment (MCI) and to examine the associations of these markers with clinical and cognitive parameters. A biochemical evaluation was performed of 62 seniors with type 2 diabetes (T2DM) and MCI, and 132 seniors with T2DM but without MCI (controls). Serum leptin and IL-1 β levels were higher and adiponectin concentration was lower in MCI patients than controls. In MCI subjects, adiponectin level was negatively correlated with leptin, IL-1 β levels and BMI. Leptin concentration was correlated with IL-1 β level. Univariate logistic regression models revealed that the factors which increased the likelihood of diagnosis of MCI in elderly patients with T2DM were higher levels of HbA1c, leptin, IL-1 β and triglycerides, as well as lower levels of adiponectin and HDL cholesterol. Similarly, previous CVD, hypertension, hyperlipidemia, retinopathy, nephropathy, hypoglycemia, longer duration of diabetes, increased number of co-morbidities, older age, fewer years of formal education were found to be associated with MCI. The multivariable model indicated fewer years of formal education, previous CVD, hypertension, increased number of co-morbidities, higher HbA1c and IL-1 β levels and lower adiponectin level. Elderly diabetic patients with MCI have higher levels of leptin and IL-1 β and lower levels of adiponectin. Further prospective studies are needed to determine the role of these markers in the progression to dementia.
authors.affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, ul. Pomorska 251, 92-213, Lodz, Poland. magoca@poczta.onet.pl.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Gorska-Ciebiada
authors.affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, ul. Pomorska 251, 92-213, Lodz, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Saryusz-Wolska
authors.affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, ul. Pomorska 251, 92-213, Lodz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Borkowska
authors.affiliation: Department of General and Oncological Pneumology, Medical University of Lodz, ul. Kopcinskiego 22, 90-153, Lodz, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Ciebiada
authors.affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, ul. Pomorska 251, 92-213, Lodz, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Loba
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015415:Biomarkers / Q000097:blood; D060825:Cognitive Dysfunction / Q000150:complications / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D053583:Interleukin-1beta; D020738:Leptin
keywords: Adiponectin; Diabetes; IL-1 β; Leptin; Mild cognitive impairment