title: A rapid and selective synthesis of α,α-fluorohalo esters via fluorohalogenative or difluorinative hydration of ynol ethers.
abstract: A Selectfluor-mediated fluorohalogenative or difluorinative hydration of ynol ethers is described, giving various α,α-fluorohalo esters including α,α-bromofluoro, α,α-chlorofluoro, α,α-fluoroiodo, and α,α-difluoro derivatives in a highly selective manner under very mild reaction conditions. The resultant products can be applied to the facile synthesis of α-monofluoro-α-amino acids. This reaction represents a new advance in the trifunctionalization of alkynes.
authors.affiliation: Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P. R. China. gangguo@zjnu.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
authors.forename: Chao
authors.initials: C
authors.lastname: Che
authors.forename: Ze
authors.initials: Z
authors.lastname: Tan
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu
mesh_terms: D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D014867:Water / Q000737:chemistry
chemical_list: D004952:Esters; D004987:Ethers; D006846:Hydrocarbons, Halogenated; D014867:Water