title: [Successful treatment of a persistent rhino-cerebral mucormycosis in a pediatric patient with a debut of acute lymphoblastic leukemia].
abstract: The fungi of the order Mucorales cause mucormycosis, which usually presents as an invasive fungal disease with rapid angioinvasion in immunocompromised patients. Rhinocerebral is the most common presentation. The lipid formulations of amphotericin B are used as primary treatment in invasive mucormycosis; the combined use of posaconazole could allow a reduction in the dose of amphotericin B improving tolerance and adherence to treatment. Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models. We present the case of a preschool patient that during the debut of acute lymphoblastic leukemia developed a rhinocerebral mucormycosis successfully responding to antifungal treatment with the combination of liposomal amphotericin and caspofungin.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Cofré
authors.forename: Milena
authors.initials: M
authors.lastname: Villarroel
authors.forename: Loreto
authors.initials: L
authors.lastname: Castellón
authors.forename: María E
authors.initials: ME
authors.lastname: Santolaya
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D000077336:Caspofungin; D002675:Child, Preschool; D054714:Echinocandins / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D055666:Lipopeptides; D015523:Maxillary Sinusitis / Q000382:microbiology / Q000628:therapy*; D009091:Mucormycosis / Q000150:complications / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000382:microbiology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; C068538:liposomal amphotericin B; D000666:Amphotericin B; D000077336:Caspofungin