title: Risk of Coronary Heart Disease in Different Criterion of Impaired Fasting Glucose: A Meta-Analysis.
abstract: The cut-point for diagnosing impaired fasting glucose (IFG) had been dispute, as reports about the associated clinical events are inconsistent. This meta-analysis evaluated the risk of coronary heart disease (CHD) in association with different criterion of IFG according to the American Diabetes Association (ADA) or the World Health Organization (WHO) Expert Group. We included prospective cohort studies with multivariate-adjusted data on IFG and CHD for analysis. The relative risks (RRs) of CHD were calculated and reported with 95% confidence intervals (95% CIs). Seventeen prospective cohort studies, comprising 527,021 individuals were included. The risks of CHD were increased in both participants with IFG defined as the ADA or WHO criterion (RR 1.11, 95% CI 1.02-1.21; and RR 1.18, 95% CI 1.10-1.28, respectively). Subgroup analyses showed that in both definition of IFG, the risk of CHD was only increased in studies with possibility of enrolling patients with increased 2 hours plasma glucose (2-h PG), or in studies with inadequate adjustment, but not in studies excluded participants with increased 2-h PG or in those with adequate adjustment of other risk factors. Our meta-analysis demonstrates that the presence of IFG was significantly associated with future risk of CHD. The risk of CHD was increased when fasting plasma glucose was as low as 100 mg/dL according to the lower cut-point of IFG by the ADA criterion. However, the risk maybe confounded by the undetected increased 2-h PG or other cardiovascular risk factors.
authors.affiliation: From the Clinical Medicine Research Institute, The Affiliated Hospital at Shunde, Southern Medical University, Foshan (TX, XC, JD, HT, YH, YH); First School of Clinical Medicine, Southern Medical University (TX, JD); Department of Pediatrics, The First Affiliated Hospital, SUN Yat-sen University, Ghangzhou (WL); and Department of Cardiology, the First People's Hospital of Shunde, Foshan, P.R. China (YH).
authors.forename: Tianyu
authors.initials: T
authors.lastname: Xu
authors.forename: Wangkai
authors.initials: W
authors.lastname: Liu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Cai
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Tang
authors.forename: Yuli
authors.initials: Y
authors.lastname: Huang
authors.forename: Yunzhao
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000367:Age Factors; D001786:Blood Glucose; D003327:Coronary Disease / Q000453:epidemiology* / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005006:Ethnicity; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D064887:Observational Studies as Topic; D011236:Prediabetic State / Q000453:epidemiology* / Q000208:ethnology; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014944:World Health Organization
chemical_list: D001786:Blood Glucose