title: The Diaza[5.5.6.6]fenestrane Skeleton-Synthesis of Leuconoxine Alkaloids.
abstract: Among the Aspidosperma-derived monoterpene indole alkaloids, the leuconoxine subgroup has drawn significant attention from the synthetic community during the past few years. This Minireview summarizes the hitherto six completed total syntheses of leuconoxines emphasizing the different strategies for assembling the key structural motif, an unprecedented diaza[5.5.6.6]fenestrane skeleton. In addition, the proposed biogenetic relationships within the group of these alkaloids are described.
authors.affiliation: Institute of Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1b, 30167, Hannover, Germany.
authors.forename: Magnus
authors.initials: M
authors.lastname: Pfaffenbach
authors.affiliation: Institute of Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1b, 30167, Hannover, Germany. tanja.gaich@oci.uni-hannover.de.
authors.forename: Tanja
authors.initials: T
authors.lastname: Gaich
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D001381:Azepines / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D001372:Aza Compounds; D001381:Azepines; D001688:Biological Products; D026121:Indole Alkaloids; C000609172:diaza(5.5.6.6)fenestrane; C000590191:leuconoxine; C062173:leuconolam
keywords: fenestrane; indole alkaloids; leuconolam; leuconoxine; natural products