title: [Noma/Cancrum oris: a neglected disease].
abstract: Noma is an aggressive orofacial gangrenous pathology that damages hard and soft tissues of the mouth and the face. Throughout the centuries it has been present around the globe, but nowadays it has practically disappeared from developed countries and mainly affects children from the most disadvantaged places, especially in Africa. Noma disease is a multifactorial process; malnutrition, debilitating diseases (bacterial or viral systemic diseases, HIV-associated immunosuppression, etc.) and intraoral infections are some of the factors implied. The characteristic tissue necrosis is produced by a polymicrobial infection. Fusobacterium necrophorum, Prevotella intermedia, Prevotella melaninogenica, Fusobacterium nucleatum, Bacteroides fragilis, Bacillus cereus, Trueperella pyogenes, spyrochetes, etc, are some of the species that have been isolated from the affected areas. Without treatment, noma is lethal in a short period of time, and the patients that survive show severe sequelae that hinder their life and interpersonal relationships. The aim of this paper is to unify the existing information and to promote wider knowledge and awareness among the population.
authors.affiliation: María García Moro, Facultad de Farmacia, Universidad de Salamanca, Spain. mgarciam@usal.es.
authors.forename: Maria
authors.initials: M
authors.lastname: García-Moro
authors.forename: Enrique
authors.initials: E
authors.lastname: García-Merino
authors.forename: Angel
authors.initials: A
authors.lastname: Martín-Del-Rey
authors.forename: Enrique
authors.initials: E
authors.lastname: García-Sánchez
authors.forename: José Elías
authors.initials: JE
authors.lastname: García-Sánchez
mesh_terms: D000349:Africa / Q000453:epidemiology; D006801:Humans; D058069:Neglected Diseases; D009625:Noma / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology / Q000401:mortality / Q000473:pathology / Q000628:therapy; D011788:Quality of Life; D012307:Risk Factors