title: Rate and duration of hospitalization for deep vein thrombosis and pulmonary embolism in real-world clinical practice.
abstract: BACKGROUND
  Current guidelines recommend initial treatment with anticoagulants at home in patients with acute deep vein thrombosis (DVT) and in patients with low-risk pulmonary embolism (PE) with adequate home circumstances. However, most of the patients with acute venous thromboembolism (VTE) are currently hospitalized regardless of their risk of short-term complications.
  
  
  OBJECTIVE
  To assess the proportion of outpatients with acute VTE initially treated in hospitals, to assess the mean duration of hospitalization, and to identify predictors for in-hospital or home treatment.
  
  
  METHODS
  Data of Italian patients enrolled in the RIETE registry from January 2006 to December 2013 were included.
  
  
  RESULTS
  Altogether 766 PE and 1,452 isolated DVT were included. Among PE patients, mean PESI score was 84 points (SD 35), and 56% of patients had a low-risk PESI score (<85). In all, 53.7% of DVT and 17.0% of PE were entirely treated at home, and 38.2% of DVT patients and 19.9% of PE patients were hospitalized for ≤5 days. On multivariate analysis, low PESI score was not independently associated with the hospitalization of PE patients.
  
  
  CONCLUSIONS
  One in every two patients with DVT and five in every six with PE are still hospitalized.
authors.affiliation: a Department of Internal Medicine , Università dell'Insubria , Varese , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Dentali
authors.affiliation: b Department of Cardiology , Ospedale Fatebenefratelli , Napoli , Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Di Micco
authors.affiliation: c Emergency Department , Ospedale Val d'Arda , Piacenza , Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Giorgi Pierfranceschi
authors.affiliation: d Centro Studi FADOI , Milano , Italy.
authors.forename: Gualberto
authors.initials: G
authors.lastname: Gussoni
authors.affiliation: e Haemostasis and Thrombosis Center, Ospedale di Udine , Udine , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barillari
authors.affiliation: f Department of Angiology , AO Moscati , Avellino , Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Amitrano
authors.affiliation: g Department of Internal Medicine , Ospedale Fatebenefratelli , Napoli , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Fontanella
authors.affiliation: h Thrombosis Center, IRCCS Istituto Clinico Humanitas , Milano , Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Lodigiani
authors.affiliation: i Critical Care Department , AOU S. Giovanni e Ruggi , Salerno , Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Guida
authors.affiliation: j Department of Angiology , Castelfranco Veneto , Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Visonà
authors.affiliation: k Department of Internal Medicine , Hospital Universitari Germans Trias i Pujol , Badalona , Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Monreal
authors.affiliation: g Department of Internal Medicine , Ospedale Fatebenefratelli , Napoli , Italy.
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Di Micco
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007558:Italy; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010045:Outpatients; D017410:Practice Guidelines as Topic; D011655:Pulmonary Embolism / Q000188:drug therapy*; D012042:Registries; D020246:Venous Thrombosis / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants
keywords: Hospitalization; treatment; venous thromboembolism