title: Genomic signatures in B-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?
abstract: Current genomic technologies have immensely improved disease classification and prognostication of major subtypes of B-cell lymphomas. This novel genetic information has not only aided in diagnosis, but has also revealed a landscape of critical molecular events that determine the biological and clinical behavior of a lymphoma. In this review, we summarized the genetic characteristics of major subtypes of B-cell lymphomas, including diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt lymphoma (BL), and mantle cell lymphoma (MCL). We illustrated how genomic profiling had identified molecular subgroups in DLBCL with varied clinical outcomes, and how a subset of genes defined prognosis in MCL and aided in BL diagnoses. We also highlighted some Phase II/III clinical trials using new therapeutic agents to determine clinical efficacy in novel molecular subgroups with distinct gene expression patterns. We believe that refinement of genomic signatures will require more intensive efforts from the biomedical research community to improve targeted therapy designs and bring a substantial change in the treatment decisions. In the next era of genomic medicine, we anticipate that a clinically and biologically relevant molecular profile of each tumor will be obtained at diagnosis to guide therapy.
authors.affiliation: Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: jiqbal@unmc.edu.
authors.forename: Javeed
authors.initials: J
authors.lastname: Iqbal
authors.affiliation: Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Hina
authors.initials: H
authors.lastname: Naushad
authors.affiliation: Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Bi
authors.affiliation: Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Jiayu
authors.initials: J
authors.lastname: Yu
authors.affiliation: Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Alyssa
authors.initials: A
authors.lastname: Bouska
authors.affiliation: Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Rohr
authors.affiliation: Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA.
authors.forename: Wang
authors.initials: W
authors.lastname: Chao
authors.affiliation: Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Fu
authors.affiliation: Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA. Electronic address: jochan@coh.org.
authors.forename: Wing C
authors.initials: WC
authors.lastname: Chan
authors.affiliation: Department of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Vose
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019468:Disease Management; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D005820:Genetic Testing; D023281:Genomics / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D058990:Molecular Targeted Therapy; D009154:Mutation; D011379:Prognosis; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents
keywords: Diffuse large B-cell lymphomas; Gene expression profiling; Molecular classification; Molecular prognosis; Targeted therapy