title: Multidetector Computed Tomography Findings in Pulmonary Hamartomas: A New Fat Detection Threshold.
abstract: OBJECTIVE
  The aim of the study was to determine the accuracy of multidetector computed tomography in the evaluation of histologically confirmed pulmonary hamartomas (PHs), with a special focus on fat detection.
  
  
  METHODS
  Data from 55 patients who had received a histologically confirmed diagnosis of PH and had undergone 64-slice thoracic MDCT were retrospectively evaluated.
  
  
  RESULTS
  PHs manifested predominantly as peripheral pulmonary nodules with lobulated margins. The average lesion diameter was 1.51 cm (SD 0.6 cm). Histologic analyses identified fat content in 43/55 (78.2%) surgical specimens. The accuracy, sensitivity, and specificity of fat detection at a density threshold of -40 HU were 83.7%, 100%, and 87.2%, respectively. A threshold of -33 HU yielded better results (95.3%, 100%, and 96.3%, respectively). Popcorn-like calcifications were found in only 12/55 (21.8%) PHs and were the only imaging feature suggestive of PH in 7.2% of cases. Most (66%) lesions with popcorn-like calcifications also contained fat.
  
  
  CONCLUSIONS
  The adoption of a new threshold for fat content (<-33 HU) can lead to further improvements in the overall ability to detect PHs by CT.
authors.affiliation: *Post-graduation Program in Medicine (Radiology), Federal University of Rio de Janeiro, Rio de Janeiro †Department of Radiology, Santa Casa Health Complex, Porto Alegre §Chest Imaging Division, AC Camargo Cancer Center, São Paulo, Brazil ‡Department of Radiology, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK.
authors.forename: Bruno
authors.initials: B
authors.lastname: Hochhegger
authors.forename: Carlos S
authors.initials: CS
authors.lastname: Nin
authors.forename: Giordano R T
authors.initials: GR
authors.lastname: Alves
authors.forename: Daniela R
authors.initials: DR
authors.lastname: Hochhegger
authors.forename: Vinícius V S
authors.initials: VV
authors.lastname: de Souza
authors.forename: Guilherme
authors.initials: G
authors.lastname: Watte
authors.forename: Klaus L
authors.initials: KL
authors.lastname: Irion
authors.forename: Marcos D
authors.initials: MD
authors.lastname: Guimarães
authors.forename: Edson
authors.initials: E
authors.lastname: Marchiori
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006222:Hamartoma / Q000000981:diagnostic imaging*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging; D055815:Young Adult