title: Cytotoxic phenylpropanoid glycosides from Fagopyrum tataricum (L.) Gaertn.
abstract: Fagopyrum tataricum (L.) Gaertn (tartary buckwheat) is an ancient dicotyledonous crop belonging to Polygonaceae family. Besides its benefits for human consumption, tartary buckwheat is also an important folk medicine in China for its antioxidant, antitumour, hypotensive, hypoglycaemic and hypolipidaemic activities. Phytochemical investigation of the ethyl acetate fraction of tartary buckwheat roots led to the isolation of seven new phenylpropanoid glycosides, tatarisides A-G (1-7), together with a known phenylpropanoid glycoside, diboside A (8). Their structures were elucidated by means of spectroscopic methods. All compounds (1-8) were evaluated for their cytotoxic activity against four human cancer cell lines (A-549, HCT116, ZR-75-30 and HL-60). Tatariside C (3) was the most active compound with IC50 values of 6.44-7.49μg/ml against the four tested cell lines.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China.
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China; Department of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Huatuo Road, Fuzhou 350108, PR China.
authors.forename: Changling
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China; Department of Pharmaceutical Analysis, School of Pharmacy, NingXia Medical University, 1160 Shenli Street, Yinchuan 750004, PR China.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Ma
authors.affiliation: Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China. Electronic address: qinsmmu@126.com.
authors.forename: Luping
authors.initials: L
authors.lastname: Qin
mesh_terms: D000146:Acids, Carbocyclic / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D045744:Cell Line, Tumor; D002681:China; D004365:Drugs, Chinese Herbal; D019612:Fagopyrum / Q000737:chemistry*; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal
chemical_list: D000146:Acids, Carbocyclic; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D006027:Glycosides
keywords: Cytotoxic activity; Fagopyrum tataricum (L.) Gaertn; Phenylpropanoid glycosides; Tatarisides A–G