title: [Change in Perioperative Hemostatic Function in Patients Undergoing Hepatic Resection for Primary and Metastatic Liver Cancer].
abstract: BACKGROUND
  Patients undergoing primary hepatic resection often develop hemostatic dysfunction associated with cirrhosis.
  
  
  METHODS
  We retrospectively surveyed pre- and postoperative prothrombin time (PT) and the PT expressed as international normalized ratio (PT-INR) in 39 patients undergoing primary liver resection. We also compared PT changes between primary and metastatic cancer cases (8 cases).
  
  
  RESULTS
  Postoperative PT-INR was 1.40 ± 0.38, which was significantly prolonged compared to preoperative PT-INR of 1.08 ± 0.07. Preoperative PT was over 70% in all 39 patients undergoing primary liver resection, whereas postoperative PT was less than 60% in 13 of 39 patients. No significant difference was found in preoperative PT-INR between primary and metastatic cancer cases, but postoperative PT-INR was significantly prolonged in primary cancer cases.
  
  
  CONCLUSIONS
  Patients undergoing primary liver resection are susceptible to hemostatic dysfunction, even with preoperative PT levels within normal limits.
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Komasawa
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Ueki
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Atagi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nishi
mesh_terms: D000368:Aged; D006487:Hemostasis; D006498:Hepatectomy; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D008875:Middle Aged; D059035:Perioperative Period; D012189:Retrospective Studies