title: Updates in Tumor Profiling in Gastrointestinal Cancers.
abstract: In the last decade there has been a focus on biomarkers that play a critical role in understanding molecular and cellular mechanisms which drive tumor initiation, maintenance and progression of cancers. Characterization of genomes by next-generation sequencing (NGS) has permitted significant advances in gastrointestinal cancer care. These discoveries have fueled the development of novel therapeutics and have laid the groundwork for the development of new treatment strategies. Work in colorectal cancer (CRC) has been in the forefront of these advances. With the continued development of NGS technology and the positive clinical experience in CRC, genome work has begun in esophagogastric, pancreatic, and hepatocellular carcinomas as well.
authors.affiliation: Assistant Professor of Medicine at The Warren Alpert Medical School of Brown University; Department of Medicine, Division of Hematology/Oncology, Providence, RI.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Perez
authors.affiliation: Research Director of the Comprehensive Cancer Center at Rhode Island, The Miriam and Newport hospitals and the medical director for the Brown University Oncology Group. He is a Professor of Medicine at The Warren Alpert Medical School of Brown University.
authors.forename: Howard P
authors.initials: HP
authors.lastname: Safran
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D009154:Mutation / Q000502:physiology; D010190:Pancreatic Neoplasms / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor
keywords: Tumor profiling; colorectal carcinoma; esophagogastric carcinoma; hepatocellular carcinoma; pancreatic carcinoma