title: Cortical Low-Frequency Power and Progressive Phase Synchrony Precede Successful Memory Encoding.
abstract: Neural activity preceding an event can influence subsequent memory formation, yet the precise cortical dynamics underlying this activity and the associated cognitive states remain unknown. We investigate these questions here by examining intracranial EEG recordings as 28 participants with electrodes placed for seizure monitoring participated in a verbal paired-associates memory task. We found that, preceding successfully remembered word pairs, an orientation cue triggered a low-frequency 2-4 Hz phase reset in the right temporoparietal junction with concurrent increases in low-frequency power across cortical regions that included the prefrontal cortex and left temporal lobe. Regions that exhibited a significant increase in 2-4 Hz power were functionally bound together through progressive low-frequency 2-4 Hz phase synchrony. Our data suggest that the interaction between power and phase synchrony reflects the engagement of attentional networks that in large part determine the extent to which memories are successfully encoded.
  
  
  CONCLUSIONS
  Here we investigate the spatiotemporal cortical dynamics that precede successful memory encoding. Using intracranial EEG, we observed significant changes in oscillatory power, intertrial phase consistency, and pairwise phase synchrony that predict successful encoding. Our data suggest that the interaction between power and phase synchrony reflects the engagement of attentional networks that in large part determine the extent to which memories are successfully encoded.
authors.affiliation: Surgical Neurology Branch and.
authors.forename: Rafi U
authors.initials: RU
authors.lastname: Haque
authors.affiliation: Surgical Neurology Branch and.
authors.forename: John H
authors.identifier: http://orcid.org/0000-0003-0465-1022
authors.initials: JH
authors.lastname: Wittig
authors.affiliation: Surgical Neurology Branch and.
authors.forename: Srikanth R
authors.initials: SR
authors.lastname: Damera
authors.affiliation: Office of the Clinical Director, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: Sara K
authors.identifier: http://orcid.org/0000-0002-7587-5085
authors.initials: SK
authors.lastname: Inati
authors.affiliation: Surgical Neurology Branch and kareem.zaghloul@nih.gov.
authors.forename: Kareem A
authors.initials: KA
authors.lastname: Zaghloul
mesh_terms: D000328:Adult; D001703:Biophysics; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D058407:Electroencephalography Phase Synchronization / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D017711:Nonlinear Dynamics; D013057:Spectrum Analysis; D013997:Time Factors
keywords: attention; episodic memory; phase synchrony