title: Early culture conversion and cure for extensively drug-resistant tuberculosis is possible with appropriate treatment: lessons learnt from a case study in South Africa.
abstract: Despite the relevance of extensively drug-resistant tuberculosis (XDR-TB) to global TB control efforts, case reports on patients achieving cure are scarce. The case of a patient who was treated for more than 3 years as a multidrug-resistant TB (MDR-TB) case, and who was diagnosed retrospectively with XDR-TB, is presented herein. Soon after the initiation of a capreomycin and para-aminosalicylic acid-based regimen, the patient converted and treatment was completed successfully.
authors.affiliation: Tuberculosis Epidemiology and Intervention Research Unit, South African Medical Research Council, Pretoria, South Africa.
authors.forename: Karen
authors.initials: K
authors.lastname: Shean
authors.affiliation: Brooklyn Chest Hospital, Cape Town, South Africa.
authors.forename: Sweetness
authors.initials: S
authors.lastname: Siwendu
authors.affiliation: Tuberculosis Epidemiology and Intervention Research Unit, South African Medical Research Council, Pretoria, South Africa. Electronic address: vdwalt@mrc.ac.za.
authors.forename: Martie
authors.initials: M
authors.lastname: van der Walt
mesh_terms: D000328:Adult; D010131:Aminosalicylic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002207:Capreomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D013019:South Africa / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents; D002207:Capreomycin; D010131:Aminosalicylic Acid
keywords: Culture contamination; Successful cure; XDR-TB