title: Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation.
abstract: Memory T cells are necessary for protective immunity against invading pathogens, especially under conditions of immunosuppression. However, their presence also threatens transplant survival, making transplantation a great challenge. Significant progress has been achieved in recent years in advancing our understanding of the role that memory T cells play in transplantation. This review focuses on the latest advances in our understanding of the involvement of memory T cells in graft rejection and transplant tolerance and discusses potential strategies for targeting memory T cells in order to minimize allograft rejection and optimize clinical outcomes.
authors.affiliation: Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology , Wuhan , China.
authors.forename: Kailin
authors.initials: K
authors.lastname: Lin
authors.affiliation: Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology , Wuhan , China ; Key Laboratory of Organ Transplantation, Ministry of Education , Wuhan , China ; Key Laboratory of Organ Transplantation, Ministry of Public Health , Wuhan , China.
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.affiliation: Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology , Wuhan , China ; Key Laboratory of Organ Transplantation, Ministry of Education , Wuhan , China ; Key Laboratory of Organ Transplantation, Ministry of Public Health , Wuhan , China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
keywords: allograft rejection; memory T cells; therapy; tolerance; transplantation