title: Normal mast cell numbers in the tissues of AhR-deficient mice.
abstract: The transcription factor aryl hydrocarbon receptor (AhR) acts as an immunomodulatory molecule in several immune cell lineages. Recently, it has been implicated in development and maintenance of immune cells in barrier tissues such as skin and mucosa. To investigate its role on mast cell development and maintenance in skin, peritoneal exudate cells (PECs) and lymph nodes, we studied in depth their phenotype in AhR-deficient mice. Our findings do not provide any evidence for a suspected role of the AhR in mast cell homeostasis.
authors.affiliation: DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Caroline
authors.initials: C
authors.lastname: Pilz
authors.affiliation: Division for Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Feyerabend
authors.affiliation: DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Jana
authors.identifier: http://orcid.org/0000-0002-4700-272X
authors.initials: J
authors.lastname: Sonner
authors.affiliation: DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Chiara
authors.initials: C
authors.lastname: Redaelli
authors.affiliation: DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Peter
authors.affiliation: Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Kunze
authors.affiliation: IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Haas
authors.affiliation: IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Esser
authors.affiliation: Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Knut
authors.initials: K
authors.lastname: Schäkel
authors.affiliation: DKTK Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.|Department of Neurology, University Hospital Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wick
authors.affiliation: Division for Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Hans-Reimer
authors.initials: HR
authors.lastname: Rodewald
authors.affiliation: DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.|Department of Neurology, University Hospital Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany.
authors.forename: Tobias V
authors.initials: TV
authors.lastname: Lanz
authors.affiliation: DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.|Department of Neurology, University Hospital Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Platten
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism*; D019070:Cell Lineage; D005260:Female; D005434:Flow Cytometry; D006706:Homeostasis; D007107:Immune System; D008198:Lymph Nodes / Q000473:pathology; D008407:Mast Cells / Q000166:cytology* / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009092:Mucous Membrane / Q000378:metabolism; D010537:Peritoneum / Q000378:metabolism; D010641:Phenotype; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics* / Q000378:metabolism*; D012867:Skin / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D018336:Receptors, Aryl Hydrocarbon; C484722:Ahr protein, mouse
keywords: aryl hydrocarbon receptor; mast cells; γδ T cells