title: Hepatoprotective and antioxidant effects of lycopene in acute cholestasis.
abstract: OBJECTIVE
  Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats.
  
  
  METHODS
  The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL and treated with 10 mg/kg body weight of lycopene. After 7 days of treatment, the liver functions, oxidative stress parameters, and DNA damage were evaluated.
  
  
  RESULTS
  The lycopene treatment significantly ameliorated the liver function parameters in BDL rats. It significantly reduced malondialdehyde and nitric oxide levels and enhanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats. The lycopene treatment also decreased DNA damage as assessed by comet assay in the lymphocytes and hepatocytes of the BDL rats.
  
  
  CONCLUSIONS
  These results suggest that lycopene might have protective effects on acute cholestasis.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tokaç
authors.forename: Sevtap
authors.initials: S
authors.lastname: Aydin
authors.forename: Gökçe
authors.initials: G
authors.lastname: Taner
authors.forename: Alper Bilal
authors.initials: AB
authors.lastname: Özkardeş
authors.forename: Mine
authors.initials: M
authors.lastname: Yavuz Taşlipinar
authors.forename: Mehmet
authors.initials: M
authors.lastname: Doğan
authors.forename: Halit Ziya
authors.initials: HZ
authors.lastname: Dündar
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kiliç
authors.forename: Arif Ahmet
authors.initials: AA
authors.lastname: Başaran
authors.forename: Ayşe Nurşen
authors.initials: AN
authors.lastname: Başaran
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002338:Carotenoids / Q000494:pharmacology*; D002374:Catalase / Q000097:blood; D002779:Cholestasis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D019610:Cytoprotection; D004249:DNA Damage / Q000187:drug effects*; D004195:Disease Models, Animal; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D008111:Liver Function Tests / Q000379:methods; D000077276:Lycopene; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D009569:Nitric Oxide; D002338:Carotenoids; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D000077276:Lycopene