title: An Autopsy Case of Two Distinct, Acquired Drug Resistance Mechanisms in Epidermal Growth Factor Receptor-mutant Lung Adenocarcinoma: Small Cell Carcinoma Transformation and Epidermal Growth Factor Receptor T790M Mutation.
abstract: We herein describe the case of a 63-year-old man who died from relapsed epidermal growth factor receptor gene (EGFR) exon 19 deletion lung adenocarcinoma treated with erlotinib. According to the autopsy results, he was confirmed to have small cell carcinoma without the EGFR T790M mutation in his pancreas and left kidney metastatic specimens, while the adenocarcinoma metastatic lesion in his right kidney had the EGFR T790M mutation; both retained the somatic EGFR exon 19 deletion. We herein report an autopsy case of resistance to an EGFR tyrosine kinase inhibitor via small cell carcinoma transformation and the EGFRT790M mutation in separate metastatic organs.
authors.affiliation: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases (The First Department of Internal Medicine), Faculty of Medicine, University of the Ryukyus, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Furugen
authors.forename: Kayoko
authors.initials: K
authors.lastname: Uechi
authors.forename: Jun
authors.initials: J
authors.lastname: Hirai
authors.forename: Hajime
authors.initials: H
authors.lastname: Aoyama
authors.forename: Masanao
authors.initials: M
authors.lastname: Saio
authors.forename: Naoki
authors.initials: N
authors.lastname: Yoshimi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kinjo
authors.forename: Kazuya
authors.initials: K
authors.lastname: Miyagi
authors.forename: Shusaku
authors.initials: S
authors.lastname: Haranaga
authors.forename: Futoshi
authors.initials: F
authors.lastname: Higa
authors.forename: Masao
authors.initials: M
authors.lastname: Tateyama
authors.forename: Jiro
authors.initials: J
authors.lastname: Fujita
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001344:Autopsy; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000473:pathology*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D066246:ErbB Receptors / Q000235:genetics*; D000069347:Erlotinib Hydrochloride; D017353:Gene Deletion; D018773:Genes, erbB-1 / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D000069347:Erlotinib Hydrochloride; C512478:EGFR protein, human; D066246:ErbB Receptors