title: Drug Reaction, Eosinophilia and Systemic Symptoms (DRESS) syndrome secondary to allopurinol with early lymphadenopathy and symptom relapse.
abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare condition with a mortality rate of up to 10%. Herein, we describe a case of DRESS syndrome secondary to allopurinol and which may have been precipitated by amoxicillin, the diagnostic challenge it represented and the successful treatment of the condition with corticosteroids.
authors.affiliation: Department of Microbiology and Infection, Brighton and Sussex University Hospitals NHS Trust, Brighton, East Sussex, UK.
authors.forename: Rhiannon
authors.initials: R
authors.lastname: Turney
authors.affiliation: Department of Microbiology and Infection, Brighton and Sussex University Hospitals NHS Trust, Brighton, East Sussex, UK.
authors.forename: Jordan Peter
authors.identifier: http://orcid.org/0000-0002-8228-3758
authors.initials: JP
authors.lastname: Skittrall
authors.affiliation: Department of Microbiology and Infection, Brighton and Sussex University Hospitals NHS Trust, Brighton, East Sussex, UK.
authors.forename: Joseph
authors.initials: J
authors.lastname: Donovan
authors.affiliation: Department of Microbiology and Infection, Brighton and Sussex University Hospitals NHS Trust, Brighton, East Sussex, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Agranoff
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000368:Aged; D000493:Allopurinol / Q000009:adverse effects*; D000658:Amoxicillin / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D004804:Eosinophils / Q000187:drug effects*; D005260:Female; D005334:Fever; D006801:Humans; D007958:Leukocyte Count; D012008:Recurrence
chemical_list: D000305:Adrenal Cortex Hormones; D000493:Allopurinol; D000658:Amoxicillin