title: Faecal microbiota transplantation in recurrent Clostridium difficile infection: Recommendations from the French Group of Faecal microbiota Transplantation.
abstract: Faecal microbiota transplantation is effective for treating recurrent forms of Clostridium difficile infection and its use in this indication is recommended in the most recent European and North American guidelines. In this context, faecal microbiota transplantation is beginning to be performed in France in clinical practice, while the rules governing this procedure have been defined in France only for clinical trials. To unify, secure, and evaluate practice in this field in France, the French Group of Faecal microbiota Transplantation (FGFT) was created in October 2014 with the support of the French National Society of Gastroenterology, the French Infectious Disease Society, and the National Academy of Pharmacy. We present here the deliberations of this group regarding the use of faecal microbiota transplantation for recurrent Clostridium difficile infection. The issues addressed are the indications, therapeutic sequence, delivery procedures, donor selection, methods and conditions of specimen preparation, and traceability.
authors.affiliation: Gastroenterology and Nutrition Department, AP-HP, Saint-Antoine Hospital and UPMC Paris 06 University, GRC n°03, SUVIMIC, Paris, France. Electronic address: harry.sokol@aphp.fr.
authors.forename: Harry
authors.initials: H
authors.lastname: Sokol
authors.affiliation: Infectious Diseases Department, Huriez Hospital, CHRU Lille, Lille 2 University, France.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Galperine
authors.affiliation: Functional Coprology Laboratory, Pitié Salpêtrière Hospital - Charles Foix, Paris Descartes University, AP-HP and EA 4065, Paris, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Kapel
authors.affiliation: Pharmacy Academy, Paris, France; Microbiology Department, Pharmacy Faculty, Paris-Sud University, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bourlioux
authors.affiliation: Gastroenterology and Nutrition Department, AP-HP, Saint-Antoine Hospital and UPMC Paris 06 University, GRC n°03, SUVIMIC, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Seksik
authors.affiliation: C. difficile National Reference Laboratory, Saint-Antoine Hospital, AP-HP et UPMC Paris 06 University, GRC N°2 EPIDIFF, Paris, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Barbut
authors.affiliation: Gastro-enterology Department, Hôpital Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Scanzi
authors.affiliation: Pharmacy Academy, Paris, France; Clinical Pharmacy Department, Paris University Hospital, AP-HP, Paris France.
authors.forename: François
authors.initials: F
authors.lastname: Chast
authors.affiliation: Pharmacy Academy, Paris, France; Clinical Pharmacy Department, Paris University Hospital, AP-HP, Paris France.
authors.forename: Rui
authors.initials: R
authors.lastname: Batista
authors.affiliation: Gastro-enterology Department, Beaujon Hospital, AP-HP, and Paris 7 University, Clichy, France.
authors.forename: Francisca
authors.initials: F
authors.lastname: Joly
authors.affiliation: Pharmacy Department, Preparation Unit, Saint-Antoine Hospital, AP-HP, Paris, France.
authors.forename: Anne-Christine
authors.initials: AC
authors.lastname: Joly
authors.affiliation: EA 4043, Pharmacy Faculty, Paris Sud University, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Collignon
authors.affiliation: Infectious Diseases Department, Huriez Hospital, CHRU Lille, Lille 2 University, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Guery
authors.affiliation: Gastroenterology and Nutrition Department, AP-HP, Saint-Antoine Hospital and UPMC Paris 06 University, GRC n°03, SUVIMIC, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Beaugerie
mesh_terms: D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000628:therapy; D046148:Donor Selection; D004761:Enterocolitis, Pseudomembranous / Q000628:therapy*; D000069467:Fecal Microbiota Transplantation / Q000379:methods*; D005602:France; D005762:Gastroenterology; D006801:Humans; D018579:Patient Selection; D012008:Recurrence
keywords: Clostridium difficile; Faecal microbiota transplantation; Recommendations