title: Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene.
abstract: Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.
authors.affiliation: Genes to Cognition Programme, Centre for Clinical Brain Sciences, University of Edinburgh, Chancellors Building, 47 Little France Crescent, Edinburgh UK EH16 4SB.|Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton Cambridgeshire UK CB10 1SA.
authors.forename: J
authors.initials: J
authors.lastname: Nithianantharajah
authors.affiliation: The Patrick Wild Centre, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh UK EH10 5HF.|Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh UK EH10 5HF.
authors.forename: A G
authors.initials: AG
authors.lastname: McKechanie
authors.affiliation: Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh UK EH10 5HF.
authors.forename: T J
authors.initials: TJ
authors.lastname: Stewart
authors.affiliation: Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh UK EH10 5HF.
authors.forename: M
authors.initials: M
authors.lastname: Johnstone
authors.affiliation: Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh UK EH10 5HF.
authors.forename: D H
authors.initials: DH
authors.lastname: Blackwood
authors.affiliation: Institute of Medical Sciences, University of Aberdeen, Aberdeen UK AB25 2ZD.
authors.forename: D
authors.initials: D
authors.lastname: St Clair
authors.affiliation: Genes to Cognition Programme, Centre for Clinical Brain Sciences, University of Edinburgh, Chancellors Building, 47 Little France Crescent, Edinburgh UK EH16 4SB.|Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton Cambridgeshire UK CB10 1SA.
authors.forename: S G N
authors.initials: SG
authors.lastname: Grant
authors.affiliation: Department of Psychology, University of Cambridge &The MRC and Wellcome Trust Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge UK CB2 3EB.
authors.forename: T J
authors.initials: TJ
authors.lastname: Bussey
authors.affiliation: Department of Psychology, University of Cambridge &The MRC and Wellcome Trust Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge UK CB2 3EB.
authors.forename: L M
authors.initials: LM
authors.lastname: Saksida
mesh_terms: D000328:Adult; D000818:Animals; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis* / Q000235:genetics; D056915:DNA Copy Number Variations; D003936:Diagnosis, Computer-Assisted; D005260:Female; D051528:Guanylate Kinases / Q000235:genetics*; D006801:Humans; D008297:Male; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008875:Middle Aged; D009154:Mutation; D010775:Photic Stimulation; D014176:Protein Biosynthesis; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D065853:Spatial Learning; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D014584:User-Computer Interface; D055815:Young Adult
chemical_list: D025521:Tumor Suppressor Proteins; C496468:DLG2 protein, human; D051528:Guanylate Kinases