title: A case of Erdheim Chester disease with central nervous system involvement.
abstract: Erdheim Chester disease (ECD) is a rare non-Langerhans cell histiocytosis, commonly involving the musculoskeletal system. Other tissue can also be involved, including the central nervous system with wide spectrum of clinical features, at times being nonspecific. This can cause diagnostic dilemmas with delay in diagnosis and initiation of therapy. Here we describe a 63-year-old man who had presented with ataxia and behavioral changes, bony pains, weight loss, and fatigue. His computed tomography (CT), 99Tc scintigraphy and histopathological features on bone biopsy were consistent with ECD. Thus, ECD should be considered as a differential diagnosis in patients presenting with bony pain and nonspecific features of multiorgan involvement.
authors.affiliation: Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Patil
authors.affiliation: Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Karthik
authors.initials: K
authors.lastname: Muthusamy
authors.affiliation: Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Sanjith
authors.initials: S
authors.lastname: Aaron
authors.affiliation: Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Mathew
authors.initials: M
authors.lastname: Alexander
authors.affiliation: Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Nanda
authors.initials: N
authors.lastname: Kachare
authors.affiliation: Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Sunithi
authors.initials: S
authors.lastname: Mani
authors.affiliation: Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Sniya
keywords: Erdheim Chester disease; histiocytosis; sclerotic bone