title: Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.
abstract: Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.
authors.affiliation: CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia. Thomas.Kohl@csiro.au.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Kohl
authors.affiliation: CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia. christian.hornung@csiro.au.
authors.forename: Christian H
authors.initials: CH
authors.lastname: Hornung
authors.affiliation: CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia. john.tsanaktsidis@csiro.au.
authors.forename: John
authors.initials: J
authors.lastname: Tsanaktsidis
mesh_terms: D000586:Amination; D060326:Chemistry Techniques, Synthetic; D004952:Esters
chemical_list: D004952:Esters
keywords: amination; continuous flow processing; flow chemistry; process intensification