title: Ligand-Independent Mechanisms of Notch Activity.
abstract: Interaction between the Notch receptor and Delta-Serrate-Lag2 (DSL) ligands is generally deemed to be the starting point of the Notch signaling cascade, after which, Notch is cleaved and the intracellular domain acts as a transcriptional coactivator. By contrast, Notch protein can become activated independent of ligand stimulus through recently identified endosomal trafficking routes as well as through aberrant regulation of Notch components during Notch trafficking, ubiquitination, and degradation. In this review, we summarize genes implicated in ligand-independent Notch activity and remark on the mechanisms by which this process could occur.
authors.affiliation: Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA; Current Address: Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
authors.forename: William Hunt
authors.initials: WH
authors.lastname: Palmer
authors.affiliation: Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA. Electronic address: wumin@bio.fsu.edu.
authors.forename: Wu-Min
authors.initials: WM
authors.lastname: Deng
mesh_terms: D000818:Animals; D011992:Endosomes / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D011485:Protein Binding / Q000502:physiology; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D008024:Ligands; D051880:Receptors, Notch
keywords: Drosophila; Notch signaling; developmental biology; noncanonical cell signaling