title: Drug-induced systemic lupus erythematosus in a child after 3 years of treatment with carbamazepine.
abstract: Drug-induced lupus erythematosus (DILE) is a less severe variant of systemic lupus erythematosus (SLE) that generally resolves within weeks or months after the withdrawal of the implicated drug. DILE is unusual during childhood, with the most frequent age of presentation being at 50-70 years of age. Among different drugs, most commonly procainamide and hydralazine have been implicated as a cause of DILE. However carbamazepine (CBZ) is considered a low-risk drug and very few cases have been reported in children. We describe the case of CBZ-induced SLE in a 9-year-old girl following 3 years of CBZ therapy. This case report shows that drug-induced SLE is an important side-effect to be considered, even after long-term treatment with CBZ, and also during childhood.
authors.affiliation: Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Molina-Ruiz
authors.affiliation: Department of Dermatology, Hospital San Agustín, Seville, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Lasanta
authors.affiliation: Department of Paediatrics, Hospital Virgen del Rocío, Seville, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Barcia
authors.affiliation: Department of Dermatology, Hospital Virgen del Rocío, Seville, Spain.
authors.forename: Elisa
authors.initials: E
authors.lastname: Pérez-Vega
authors.affiliation: Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Requena
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D002648:Child; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine
keywords: carbamazepine; drug-induced lupus erythematosus; paediatric age; systemic lupus erythematosus