title: Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection.
abstract: Single institution and population-based studies highlight that infectious complications following transrectal ultrasound guided prostate needle biopsy (TRUS PNB) are increasing. Such infections are largely attributable to quinolone resistant microorganisms which colonize the rectal vault and are translocated into the bloodstream during the biopsy procedure. A povidone iodine rectal preparation (PIRP) at time of biopsy is a simple, reproducible method to reduce rectal microorganism colony counts and therefore resultant infections following TRUS PNB. All patients are administered three days of oral antibiotic therapy prior to biopsy. The PIRP technique involves initially positioning the patient in the standard manner for a TRUS PNB. Following digital rectal examination, 15 ml of a 10% solution of commercially available povidone iodine is mixed with 5 ml of 1% lidocaine jelly to create slurry. A 4 cmx4 cm sterile gauze is soaked in this slurry and then inserted into the rectal vault for 2 min after which it is removed. Thereafter, a disposable cotton gynecologic swab is used to paint both the perianal area and the rectal vault to a distance of 3 cm from the anus. The povidone iodine solution is then allowed to dry for 2-3 min prior to proceeding with standard transrectal ultrasonography and subsequent biopsy. This PIRP technique has been in practice at our institution since March of 2012 with an associated reduction of post-biopsy infections from 4.3% to 0.6% (p=0.02). The principal advantage of this prophylaxis regimen is its simplicity and reproducibility with use of an easily available, inexpensive agent to reduce infections. Furthermore, the technique avoids exposing patients to additional systemic antibiotics with potential further propagation of multi-drug resistant organisms. Usage of PIRP at TRUS PNB, however, is not applicable for patients with iodine or shellfish allergies.
authors.affiliation: Division of Urology, Penn State Milton S. Hershey Medical Center; jraman@hmc.psu.edu.
authors.forename: Jay D
authors.initials: JD
authors.lastname: Raman
authors.affiliation: Division of Urology, Penn State Milton S. Hershey Medical Center.
authors.forename: Kathleen K
authors.initials: KK
authors.lastname: Lehman
authors.affiliation: Department of Veterinary and Biomedical Sciences, Penn State University.
authors.forename: Kalyan
authors.initials: K
authors.lastname: Dewan
authors.affiliation: Department of Veterinary and Biomedical Sciences, Penn State University.
authors.forename: Girish
authors.initials: G
authors.lastname: Kirimanjeswara
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000379:methods; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods*; D002939:Ciprofloxacin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011206:Povidone-Iodine / Q000008:administration & dosage*; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D015203:Reproducibility of Results; D018805:Sepsis / Q000209:etiology / Q000517:prevention & control; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage; D018084:Ultrasonography, Interventional / Q000379:methods; D014552:Urinary Tract Infections / Q000209:etiology / Q000517:prevention & control
chemical_list: D000891:Anti-Infective Agents, Local; D002939:Ciprofloxacin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D011206:Povidone-Iodine