title: Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents.
abstract: Breast cancer is probably the most prevalent cancer in women. The development of resistance to therapeutic agents and lack of targeted therapy for breast cancer cells provide motivation to identify new compounds for the treatment. With this objective in mind, a new series of 3-fluoro-4-methoxyphenyl group based 1,3,5-trisubstituted aryl-5-hydroxypyrazoline analogues 4a-l was synthesized through multi-step reaction sequence. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR, LC-MS and elemental analysis. They were screened for their in vitro anticancer and in vitro antioxidant activities. Among the tested compounds 4h, 4c and particularly 4i displayed promising cytotoxic effect on breast cancer cell lines. The compounds were also found to possess antioxidant activity when tested against DPPH free radical. Overall, this work has contributed to the development of promising leads for anticancer and antioxidant activities.
authors.affiliation: Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, India.
authors.lastname: Dinesha
authors.affiliation: Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, India.
authors.forename: Shivapura
authors.initials: S
authors.lastname: Viveka
authors.affiliation: Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576 104, India.
authors.forename: Bolli Keerthi
authors.initials: BK
authors.lastname: Priya
authors.affiliation: Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576 104, India.
authors.forename: K Sreedhara Ranganath
authors.initials: KS
authors.lastname: Pai
authors.affiliation: Institution of Excellence, Vijnana Bhavana, University of Mysore, Mysore 570 006, India.
authors.forename: Shivalingegowda
authors.initials: S
authors.lastname: Naveen
authors.affiliation: Department of Studies in Physics, University of Mysore, Mysore 570 006, India.
authors.forename: Neratur K
authors.initials: NK
authors.lastname: Lokanath
authors.affiliation: Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, India. Electronic address: nagarajagk@gmail.com.
authors.forename: Gundibasappa Karikannar
authors.initials: GK
authors.lastname: Nagaraja
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005461:Fluorine / Q000737:chemistry / Q000494:pharmacology*; D005609:Free Radicals / Q000037:antagonists & inhibitors; D006801:Humans; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D010851:Picrates / Q000037:antagonists & inhibitors; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014709:Vero Cells
chemical_list: C000609847:5-hydroxypyrazoline; D000970:Antineoplastic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D010851:Picrates; D011720:Pyrazoles; D005461:Fluorine; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Anticancer activity; Antioxidant activity; Characterization; Hydroxypyrazolines; Synthesis