title: Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.
abstract: The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemias, and ability to modulate receptor signaling. Siglec-targeting approaches with therapeutic potential encompass antibody- and glycan-based strategies. Several antibody-based therapies are in clinical trials and continue to be developed for the treatment of lymphoma/leukemia and autoimmune disease, while the therapeutic potential of glycan-based strategies for cargo delivery and immunomodulation is a promising new approach. Here we review these strategies with special emphasis on emerging approaches and disease areas that may benefit from targeting the Siglec family.
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Angata
authors.affiliation: Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Corwin M
authors.initials: CM
authors.lastname: Nycholat
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA. Electronic address: mmacaule@scripps.edu.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Macauley
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D005936:Glucans / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007938:Leukemia / Q000276:immunology / Q000628:therapy*; D008223:Lymphoma / Q000276:immunology / Q000628:therapy*; D063265:Sialic Acid Binding Immunoglobulin-like Lectins / Q000737:chemistry / Q000276:immunology*
chemical_list: D000906:Antibodies; D005936:Glucans; D063265:Sialic Acid Binding Immunoglobulin-like Lectins
keywords: Siglecs; antibodies; glycans; sialic acid; synthetic ligands