title: Small Molecules in the Cone Snail Arsenal.
abstract: Cone snails are renowned for producing peptide-based venom, containing conopeptides and conotoxins, to capture their prey. A novel small-molecule guanine derivative with unprecedented features, genuanine, was isolated from the venom of two cone snail species. Genuanine causes paralysis in mice, indicating that small molecules and not just polypeptides may contribute to the activity of cone snail venom.
authors.affiliation: Interdisciplinary Centre of Marine and Environmental Research, CIIMAR/CIMAR, and Faculty of Sciences, University of Porto , 40150-123 Porto, Portugal.
authors.forename: Jorge L B
authors.initials: JL
authors.lastname: Neves
authors.forename: Zhenjian
authors.initials: Z
authors.lastname: Lin
authors.forename: Julita S
authors.initials: JS
authors.lastname: Imperial
authors.affiliation: Interdisciplinary Centre of Marine and Environmental Research, CIIMAR/CIMAR, and Faculty of Sciences, University of Porto , 40150-123 Porto, Portugal.
authors.forename: Agostinho
authors.initials: A
authors.lastname: Antunes
authors.affiliation: Interdisciplinary Centre of Marine and Environmental Research, CIIMAR/CIMAR, and Faculty of Sciences, University of Porto , 40150-123 Porto, Portugal.
authors.forename: Vitor
authors.initials: V
authors.lastname: Vasconcelos
authors.forename: Baldomero M
authors.initials: BM
authors.lastname: Olivera
authors.forename: Eric W
authors.initials: EW
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D052078:Conus Snail / Q000737:chemistry*; D006147:Guanine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007536:Isomerism; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010243:Paralysis / Q000139:chemically induced
chemical_list: C000604182:genuanine; D006147:Guanine