title: Clinico-pathological Analysis of the Lungs from Patients with Lung Transplantation in a Single Institute in Korea.
abstract: Recently, the numbers of lung transplantation (LT) has been increased in Korea. However, post-LT outcome has not been successful in all patients, which may be partially affected by the primary lung disease. Therefore comprehensive understanding in original pathological diagnosis of patients with LT would be needed for achieving better clinical outcome. To address this issue, we performed clinico-pathological analysis of the explanted lungs from 29 patients who underwent LT over a 9-yr period in Seoul National University Hospital. Among them, 26 patients received single (1/26) or double (25/26) LT, while heart-lung transplantation was performed in 3 patients. The final clinico-pathological diagnoses were idiopathic pulmonary fibrosis/usual interstitial pneumonia (UIP) (n = 6), acute interstitial pneumonia (AIP)/diffuse alveolar damage (DAD) (n = 4), AIP/non-specific interstitial pneumonia with DAD (n = 1), collagen vascular disease-related interstitial lung disease (CVD-ILD)/DAD (n = 3), CVD-ILD/UIP (n = 1), lymphangioleiomyomatosis (n = 1), bronchiectasis (n = 4), pulmonary arterial hypertension (n = 2), tuberculosis (n = 1), bronchiolitis obliterans (BO) (n = 1), and lung cancer (n = 1). Moreover, 4 patients who had chemotherapy and hematopoietic stem cell transplantation due to hematologic malignancy showed unclassifiable interstitial pneumonia with extensive fibrosis in the lungs. Our study demonstrates that pathology of the explanted lungs from Korean patients with LT is different from that of other countries except for interstitial lung disease and bronchiectasis, which may be helpful for optimization of selecting LT candidates for Korean patients.
authors.affiliation: Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hyojin
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Jeon
authors.affiliation: Department of Thoracic Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Thoracic Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. ; Xenotransplantation Research Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. ; Transplantation Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Young Tae
authors.initials: YT
authors.lastname: Kim
authors.affiliation: Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. ; Xenotransplantation Research Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. ; Department of Biomedical Sciences, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Doo Hyun
authors.initials: DH
authors.lastname: Chung
mesh_terms: D040981:Acinetobacter baumannii / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D000368:Aged; D001987:Bronchiectasis / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000473:pathology*; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D017563:Lung Diseases, Interstitial / Q000473:pathology*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D016896:Treatment Outcome; D065507:Vancomycin-Resistant Enterococci / Q000302:isolation & purification; D055815:Young Adult
keywords: Bronchiectasis; Histology; Lung; Lung Disease, Interstitial; Lung Transplantation; Transplantation