title: Pilot trial of light therapy for depression in hospitalized patients with cystic fibrosis.
abstract: BACKGROUND
  Depression is common in cystic fibrosis (CF) and linked with worse outcomes during hospitalization. Bright-light therapy during hospitalizations augments antidepressant regimens and reduces length of stay (LOS) in depressed non-CF patients, but has not been examined in CF METHODS: Thirty subjects used a light box emitting 10,000lx for 30min each day for 7 straight days following hospital admission for pulmonary exacerbation. Depressive symptom severity (QIDS-C) and quality of life factors (CFQ-R) were recorded pre/post light therapy.
  
  
  RESULTS
  Eighty percent of subjects had at least mild depressive symptoms upon admission. Hospitalized CF patients had a significantly lower mean LOS of 11.0±3.6 days compared to a historical cohort from the year prior (13.3±4.4 days, p value=0.038). There was a significant decrease in depressive symptoms for all subjects receiving light therapy (p value<0.0001). There was no relation between depressive symptoms and lung function or vitamin D. Six out of twelve quality of life indicators improved with light therapy including the domains of vitality, emotion, and health perceptions. There were no adverse events reported.
  
  
  CONCLUSIONS
  As a pilot study, the design was limited by a lack of a control group and possible confounding effects of hospitalization treatment on systemic symptoms.
  
  
  CONCLUSIONS
  Light therapy was well tolerated by hospitalized CF patients and resulted in improved depressive symptoms and quality of life. Light therapy was associated with a reduced length of stay. Large, randomized trials of light therapy may be indicated for hospitalized CF patients.
authors.affiliation: Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, United States; Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, OH, United States. Electronic address: Benjamin.Kopp@NationwideChildrens.org.
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Kopp
authors.affiliation: Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.affiliation: Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
authors.forename: Princy
authors.initials: P
authors.lastname: Ghera
authors.affiliation: Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
authors.forename: Alpa
authors.initials: A
authors.lastname: Patel
authors.affiliation: Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
authors.forename: Stephen
authors.initials: S
authors.lastname: Kirkby
authors.affiliation: Center for Innovation in Pediatric Practice, Nationwide Children's Hospital/Ohio State Medical Center, Department of Psychiatry, Columbus, OH, United States.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kowatch
authors.affiliation: Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, United States; The Sleep Disorders Center, Nationwide Children's Hospital, Columbus, OH, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Splaingard
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications* / Q000628:therapy*; D003863:Depression / Q000150:complications* / Q000628:therapy*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay; D008297:Male; D010789:Phototherapy; D010865:Pilot Projects; D011788:Quality of Life; D055815:Young Adult
keywords: Affect; Cost-effectiveness; Length of stay; Quality of life