title: Unprocessed red meat and processed meat consumption and risk of stroke in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC).
abstract: OBJECTIVE
  High intakes of unprocessed red or processed meat may increase the risk of stroke. We aimed to examine the association between unprocessed red meat, processed meat and total red meat consumption and risk of total stroke and ischaemic stroke.
  
  
  METHODS
  Cox proportional hazards regression analyses were conducted based on the data for 41,020 men and women aged 29-69 years at baseline.
  
  
  RESULTS
  During a mean follow-up of 13.8 years, 674 incident cases of stroke (531 ischaemic strokes, 79 haemorrhagic strokes, 42 subarachnoid haemorrhages and 22 mixed or unspecified events) were identified. After multiple adjustment, unprocessed red meat, processed meat and total red meat consumption were not correlated with incidence of total stroke or ischaemic stroke in either men or women. The hazard ratios (HRs) for unprocessed red meat and processed meat and risk of total stroke comparing the highest with the lowest quintiles were, respectively, 0.81 (95% confidence interval (CI) 0.54-1.21; P-trend=0.15) and 0.92 (95% CI 0.64-1.32; P-trend=0.82) in men and 1.21 (95% CI 0.79-1.85; P-trend=0.10) and 0.81 (95% CI 0.51-1.27; P-trend=0.17) in women. The HRs for unprocessed red meat and processed meat and risk of ischaemic stroke were, respectively, 0.80 (95% CI 0.51-1.25; P-trend=0.51) and 0.86 (95% CI 0.57-1.29; P-trend=0.77) in men and 1.24 (95% CI 0.74-2.05; P-trend=0.13) and 0.82 (95% CI 0.47-1.42; P-trend=0.31) in women.
  
  
  CONCLUSIONS
  In the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, unprocessed red meat and processed meat consumption were not associated with risk of stroke in men or women.
authors.affiliation: Public Health Department of Gipuzkoa, Government of the Basque Country, San Sebastian, Spain.|BioDonostia Research Institute, San Sebastian, Spain.|Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Amiano
authors.affiliation: BioDonostia Research Institute, San Sebastian, Spain.|Public Health Department of Gipuzkoa, Government of the Basque Country, San Sebastian, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Chamosa
authors.affiliation: Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.|Public Health Department of Gipuzkoa, Government of the Basque Country, San Sebastian, Spain.|BioDonostia Research Institute, San Sebastian, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Etxezarreta
authors.affiliation: Public Health Department of Gipuzkoa, Government of the Basque Country, San Sebastian, Spain.|BioDonostia Research Institute, San Sebastian, Spain.|Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Arriola
authors.affiliation: Andalusian School of Public Health and Biosanitary Research Institute of Granada (Granada.ibs), Granada, Spain.|Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Sánchez
authors.affiliation: Navarre Public Health Institute, Pamplona, Spain.|Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Ardanaz
authors.affiliation: Andalusian School of Public Health and Biosanitary Research Institute of Granada (Granada.ibs), Granada, Spain.|Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Molina-Montes
authors.affiliation: Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain.|Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
authors.forename: M-D
authors.initials: MD
authors.lastname: Chirlaque
authors.affiliation: Navarre Public Health Institute, Pamplona, Spain.|Research Network for Health Services in Chronic Disease (REDISSEC), Pamplona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Moreno-Iribas
authors.affiliation: Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain.|Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
authors.forename: J-M
authors.initials: JM
authors.lastname: Huerta
authors.affiliation: BioDonostia Research Institute, San Sebastian, Spain.|Donostia University Hospital, San Sebastian, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Egües
authors.affiliation: Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain.|Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.|Department of Health and Social Sciences, University of Murcia, Murcia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Navarro
authors.affiliation: Andalusian School of Public Health and Biosanitary Research Institute of Granada (Granada.ibs), Granada, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Requena
authors.affiliation: Public Health and Health Planning Directorate, Oviedo, Spain.
authors.forename: J-R
authors.initials: JR
authors.lastname: Quirós
authors.affiliation: Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fonseca-Nunes
authors.affiliation: Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Jakszyn
authors.affiliation: Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
authors.forename: C-A
authors.initials: CA
authors.lastname: González
authors.affiliation: Public Health Department of Gipuzkoa, Government of the Basque Country, San Sebastian, Spain.|BioDonostia Research Institute, San Sebastian, Spain.|Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Dorronsoro
mesh_terms: D000328:Adult; D000368:Aged; D004032:Diet; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008461:Meat Products; D008875:Middle Aged; D015596:Nutrition Assessment; D016016:Proportional Hazards Models; D011446:Prospective Studies; D000069466:Red Meat; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D044465:White People