title: Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease.
abstract: APC is a tumor suppressor gene that is involved in the processes of cell migration and adhesion, transcriptional activation, and apoptosis. The goal of this study was to evaluate the contribution of the APC rs383830 polymorphism to coronary heart disease (CHD) in Han Chinese. A total of 783 patients with CHD and 737 controls were tested in the current association study. Although our study did not identify an association between the APC rs383830 polymorphism and CHD, a breakdown analysis by gender indicated there was a significant contribution of the rs383830 T allele to the risk of CHD in males (P = 0.046, odds ratio = 1.267, 95% confidence interval = 1.004-1.598). In conclusion, our study suggested a male-specific association of the APC rs383830 polymorphism with CHD.
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Zhong
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China.
authors.forename: X W
authors.initials: XW
authors.lastname: Zheng
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.
authors.forename: H D
authors.initials: HD
authors.lastname: Ye
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Cui
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China.
authors.forename: W P
authors.initials: WP
authors.lastname: Du
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Zhang
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Fei
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China.
authors.forename: S Y
authors.initials: SY
authors.lastname: Lin
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China.
authors.forename: J
authors.initials: J
authors.lastname: Su
authors.affiliation: Ningbo First Hospital School of Medicine, Ningbo University, Zhejiang, China chxmin@hotmail.com.
authors.forename: X M
authors.initials: XM
authors.lastname: Chen
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.
authors.forename: S W
authors.initials: SW
authors.lastname: Duan
mesh_terms: D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics*; D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D003327:Coronary Disease / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors
chemical_list: C555337:APC protein, human; D025601:Adenomatous Polyposis Coli Protein