title: Persistent Food Allergy and Food Allergy Coexistent with Eczema Is Associated with Reduced Growth in the First 4 Years of Life.
abstract: BACKGROUND
  Food allergy has been associated with lower weight and height in cross-sectional studies in children; however, this has not been investigated in longitudinal studies to explore growth over time, and previous studies have not accounted for coexisting eczema.
  
  
  OBJECTIVE
  The objective of this study was to examine the association of IgE-mediated food allergy and eczema with anthropometric measures at 1 and 4 years of age.
  
  
  METHODS
  In the HealthNuts population-based cohort, infants recruited at age 1 year underwent a skin prick test to egg, peanut, and sesame; those sensitized had oral food challenges. Food challenges repeated at 4 years determined food allergy persistence or resolution. Eczema was defined as parent report of eczema diagnosis. Parent-reported weight and height and child health record data were used to calculate age- and sex-adjusted percentiles from World Health Organization charts. Multivariable linear regression models were fitted to examine the effect of food allergy and eczema on weight and height controlling for potential confounders.
  
  
  RESULTS
  Children with both food allergy and eczema at age 1 had lower percentiles for mean weight (51.3 vs 58.3 percentile, P = .001) and height (48.4 vs 53.4, P = .028) at age 1 compared with those with neither condition. There was no difference for children with only food allergy or eczema at age 1. By age 4, children with persistent food allergy and persistent eczema, but not those with resolved food allergy, were still shorter and lighter.
  
  
  CONCLUSIONS
  Children with both food allergy and eczema were shorter and lighter throughout early childhood, with more pronounced differences in those with persistent food allergy.
authors.affiliation: Department of Paediatrics, University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia.
authors.forename: Cara
authors.initials: C
authors.lastname: Beck
authors.affiliation: Murdoch Children's Research Institute, Melbourne, Australia; Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Australia.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Koplin
authors.affiliation: Murdoch Children's Research Institute, Melbourne, Australia; Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Australia.
authors.forename: Shyamali
authors.initials: S
authors.lastname: Dharmage
authors.affiliation: Department of Paediatrics, University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia.
authors.forename: Melissa
authors.initials: M
authors.lastname: Wake
authors.affiliation: Murdoch Children's Research Institute, Melbourne, Australia; Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Australia.
authors.forename: Lyle
authors.initials: L
authors.lastname: Gurrin
authors.affiliation: Department of Paediatrics, University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia.
authors.forename: Vicki
authors.initials: V
authors.lastname: McWilliam
authors.affiliation: Department of Paediatrics, University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia.
authors.forename: Mimi
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Paediatrics, University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia.
authors.forename: Cong
authors.initials: C
authors.lastname: Sun
authors.affiliation: Murdoch Children's Research Institute, Melbourne, Australia.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Foskey
authors.affiliation: Department of Paediatrics, University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia; School of Inflammation and Repair, University of Manchester, Manchester, United Kingdom. Electronic address: katie.allen@rch.org.au.
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: Allen
mesh_terms: D000886:Anthropometry; D001315:Australia / Q000453:epidemiology; D002675:Child, Preschool; D015331:Cohort Studies; D004485:Eczema / Q000150:complications / Q000453:epidemiology*; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000150:complications / Q000453:epidemiology*; D006130:Growth Disorders / Q000453:epidemiology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007223:Infant; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E
keywords: Body mass index; Eczema; Food allergy; Growth; Height; Infants; Weight