title: Impact of Regional Vein Thrombosis in Patients with Klebsiella pneumoniae Liver Abscess.
abstract: Klebsiella liver abscess (KLA) is an emerging infection in Asia caused by hypermucoviscous strains of Klebsiella pneumoniae. It is associated with thrombophlebitis of portal and hepatic veins. The natural history and role of anticoagulation for this regional thrombophlebitis is unclear. In a retrospective study of 169 subjects with KLA over 7 years, thrombophlebitis was identified in 53/169 (31.4%). Only 1 received therapeutic anticoagulation. Despite this 30/49 (73.2%) of those with follow up scan available showed improvement or recanalization (mean duration between scans 44 days). Abscess resolution was associated with improvement in thrombophlebitis.
authors.affiliation: University Medicine Cluster, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: James S
authors.initials: JS
authors.lastname: Molton
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Hematology-Oncology, National University Health System, Singapore.
authors.forename: Yen Lin
authors.initials: YL
authors.lastname: Chee
authors.affiliation: Department of Diagnostic Imaging, National University Health System, Singapore.
authors.forename: Tiffany P
authors.initials: TP
authors.lastname: Hennedige
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Sudhakar K
authors.initials: SK
authors.lastname: Venkatesh
authors.affiliation: University Medicine Cluster, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Sophia
authors.initials: S
authors.lastname: Archuleta
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D007710:Klebsiella Infections / Q000150:complications*; D007711:Klebsiella pneumoniae / Q000302:isolation & purification*; D008100:Liver Abscess / Q000150:complications* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013924:Thrombophlebitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000925:Anticoagulants