title: An acute hemolytic transfusion reaction due to the "anti-c" rhesus antibody: A case report emphasizing the role of transfusion medicine.
abstract: Rhesus (Rh) mediated hemolytic transfusion reactions (HTR) are usually immunoglobulin G mediated and delayed onset. Rh antibodies being the cause of acute HTR (AHTR) and intravascular hemolysis are still under debate. We report here a case of a 53-year-old male who developed AHTR due to "anti-c" antibodies within 3 h of blood transfusion, precipitating fatal acute liver failure in a patient with hepatitis C related chronic liver disease. This case emphasizes the need of inclusion of antibody screening in routine pretransfusion testing as well as a critical role of transfusion medicine specialists for early diagnosis and minimizing transfusion-related morbidity and mortality.
authors.affiliation: Department of Transfusion Medicine, Global Health City, Chennai, Tamil Nadu, India.
authors.forename: Deepti
authors.initials: D
authors.lastname: Sachan
authors.affiliation: Department of Transfusion Medicine, Global Health City, Chennai, Tamil Nadu, India.
authors.forename: Rajeswari
authors.initials: R
authors.lastname: Jayakumar
authors.affiliation: Department of Hepatology and Liver Transplantation, Global Health City, Chennai, Tamil Nadu, India.
authors.forename: Joy
authors.initials: J
authors.lastname: Varghese
authors.affiliation: Department of Hepatology and Liver Transplantation, Global Health City, Chennai, Tamil Nadu, India.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Rela
keywords: Antibody; hemolytic; rhesus; transfusion; transfusion reaction