title: A dose-response curve for biodosimetry from a 6 MV electron linear accelerator.
abstract: Biological dosimetry (biodosimetry) is based on the investigation of radiation-induced biological effects (biomarkers), mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve should be constructed with respect to basic physical parameters, such as the type of ionizing radiation characterized by low or high linear energy transfer (LET) and dose rate. This study was designed to obtain dose calibration curves by scoring of dicentric chromosomes in peripheral blood lymphocytes irradiated in vitro with a 6 MV electron linear accelerator (Mevatron M, Siemens, USA). Two software programs, CABAS (Chromosomal Aberration Calculation Software) and Dose Estimate, were used to generate the curve. The two software programs are discussed; the results obtained were compared with each other and with other published low LET radiation curves. Both software programs resulted in identical linear and quadratic terms for the curve presented here, which was in good agreement with published curves for similar radiation quality and dose rates.
authors.affiliation: Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Recife, PE, BR.
authors.forename: M M P
authors.initials: MM
authors.lastname: Lemos-Pinto
authors.affiliation: Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Recife, PE, BR.
authors.forename: M
authors.initials: M
authors.lastname: Cadena
authors.affiliation: Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Recife, PE, BR.
authors.forename: N
authors.initials: N
authors.lastname: Santos
authors.affiliation: Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Recife, PE, BR.
authors.forename: T S
authors.initials: TS
authors.lastname: Fernandes
authors.affiliation: Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Recife, PE, BR.
authors.forename: E
authors.initials: E
authors.lastname: Borges
authors.affiliation: Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Recife, PE, BR.
authors.forename: A
authors.initials: A
authors.lastname: Amaral
mesh_terms: D000328:Adult; D002138:Calibration / Q000592:standards; D002869:Chromosome Aberrations / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000528:radiation effects*; D008297:Male; D010315:Particle Accelerators; D061251:Primary Cell Culture; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods