title: Dabigatran for left ventricular thrombus.
abstract: Male patient in dilated phase of hypertrophic cardiomyopathy had multiple hospitalizations during the past 2 years either due to congestive heart failure, stroke, scar epilepsy, or atrial fibrillation and ventricular tachycardia. Medication included evidence based therapy for heart failure, cordarone and warfarin. Anticoagulation had to be discontinued due to marked fluctuations in INR. Transthoracic Echocardiography (TTE) revealed a mobile mass in the left ventricle. He was treated with Dabigatran 110mg twice a day for 4 months without any bleeding or embolic episode and complete resolution of thrombus. Dabigatran is a reversible direct thrombin inhibitor and currently approved for the prevention of thromboembolic episodes in non-valvar atrial fibrillation. This case demonstrates possible thrombolytic properties of dabigatran in resolution of left ventricular thrombus.
authors.affiliation: Senior Registrar, Department of Cardiology, Bombay Hospital Institute of Medical Sciences, Bombay Hospital, 12, New Marine Lines, Mumbai, Maharashtra 400 020, India. Electronic address: drsatishskolekarpune@gmail.com.
authors.forename: Satishkumar
authors.initials: S
authors.lastname: Kolekar
authors.affiliation: Clinical Associate, Department of Cardiology, Bombay Hospital Institute of Medical Sciences, Bombay Hospital, 12, New Marine Lines, Mumbai, Maharashtra 400 020, India.
authors.forename: Chandrashekhar
authors.initials: C
authors.lastname: Munjewar
authors.affiliation: Professor and Head of Cardiology, Department of Cardiology, Bombay Hospital Institute of Medical Sciences, Bombay Hospital, 12, New Marine Lines, Mumbai, Maharashtra 400 020, India.
authors.forename: Satyavan
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000991:Antithrombins / Q000627:therapeutic use; D000069604:Dabigatran / Q000627:therapeutic use*; D004452:Echocardiography; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000991:Antithrombins; D000069604:Dabigatran
keywords: Dabigatran; Left ventricle; Mass; Thrombolytic