title: Natriuretic peptide resistance of mesenteric arteries in spontaneous hypertensive rat is alleviated by exercise.
abstract: Proximal resistance vessels, such as the mesenteric arteries, contribute substantially to the peripheral resistance. The reactivity of resistance vessels to vasoactive substance like natriuretic peptides plays an important role in the regulation of blood pressure. In current study, we investigated the reactivity of mesenteric arteries to atrial natriuretic peptide (ANP), a well known vasodilating factor, in spontaneously hypertensive rats (SHR), as well as the effects of exercise training on it. As a result, ANP-induced vasorelaxation was attenuated in SHR with significantly increased phosphodiesterase type 5 (PDE5), and decreased cGMP/ANP ratio, compared with WKY rats as control. Intriguingly, the decreased reactivity to ANP in SHR was markedly reversed by exercise training. In addition, ANP resistance of in vitro mesenteric arteries was diminished by sildenafil a potent selective inhibitor of PDE5. In conclusion, ANP resistance occurs in resistance vessels of SHR, suggesting predisposition to hypertension, which can be reversed by exercise.
authors.affiliation: Central Laboratory, Second Affiliated Hospital, Xi'an Medical University, Xi'an, China, Fourth Military Medical University, Xi'an, China. pclamper@163.com, hfzhang@fmmu.edu.cn, mz_zhu@fmmu.edu.cn.
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: X-L
authors.initials: XL
authors.lastname: Su
authors.forename: R
authors.initials: R
authors.lastname: Tie
authors.forename: P
authors.initials: P
authors.lastname: Chang
authors.forename: X-C
authors.initials: XC
authors.lastname: Zhang
authors.forename: J-B
authors.initials: JB
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Zhao
authors.forename: M-Z
authors.initials: MZ
authors.lastname: Zhu
authors.forename: H-F
authors.initials: HF
authors.lastname: Zhang
authors.forename: B-Y
authors.initials: BY
authors.lastname: Chen
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000379:methods / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
chemical_list: D009320:Atrial Natriuretic Factor